title: Dysfunction of response inhibition in eating disorders.
abstract: BACKGROUND
  Response inhibition in eating disorders (ED) has been studied using methods such as Go/No-go tasks and cognitive conflict tasks, but the results have been inconsistent with regard to the presence or absence of impaired response inhibition in ED. This may be due to variation across the studies in the characteristics of the tasks and in the degree of underweight of ED participants.
  
  
  METHODS
  We investigated the presence or absence of impaired response inhibition in an ED patient group, including many severe cases (body mass index <15 kg/m(2)), by comparing the interference effect of ED patients and healthy participants with an arrow-space interference task as the cognitive conflict task.
  
  
  RESULTS
  There was a significant interference effect on response time in healthy participants and ED patients, with no significant intergroup difference in response times. However, the interference effect on error rate was significantly greater in ED patients than healthy participants. There was no significant difference in this trend across different ED subtypes (restricting type anorexia nervosa, binge-eating/purging type anorexia nervosa, and eating disorder not otherwise specified).
  
  
  CONCLUSIONS
  Attentional control such as focused attention and sustained attention are preserved in ED patients, but there appears to be dysfunction of response inhibition. This might be the basis of poor impulse control in the eating behavior of ED patients.
authors.affiliation: a Department of Psychiatry , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Madoka
authors.initials: M
authors.lastname: Yano
authors.affiliation: a Department of Psychiatry , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Kawano
authors.affiliation: a Department of Psychiatry , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: a Department of Psychiatry , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Kohmura
authors.affiliation: a Department of Psychiatry , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Katayama
authors.affiliation: a Department of Psychiatry , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nishioka
authors.affiliation: a Department of Psychiatry , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000503:physiopathology; D001288:Attention / Q000502:physiology*; D056344:Executive Function / Q000502:physiology*; D001068:Feeding and Eating Disorders / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008875:Middle Aged; D055815:Young Adult
keywords: Anorexia nervosa; Binge-eating/purging; Eating disorders; Response inhibition; Stroop interference