title: Primary hyperparathyroidism in pregnancy.
abstract: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders in the general population but is rarely diagnosed during pregnancy. Symptoms of gestational PHPT may be unrecognized, or masked by physiological changes in calcium homeostasis associated with pregnancy. Gestational PHPT may have severe consequences for both mother and fetus. However, nowadays, gestational PHPT is usually diagnosed in earlier stages and milder forms, with low complication rates. Treatment should be individually tailored according to gestational age, the severity of hypercalcemia, and the risk-benefit balance. The conservative approach is preferred in mild forms, whereas surgery, usually performed during the second trimester, is reserved for symptomatic hypercalcemic PHPT. Given the young age of the patients, genetic causes should be considered.
authors.affiliation: Service d'endocrinologie et des maladies de la reproduction, CHU de Bicêtre, AP-HP, 94275 Le Kremlin-Bicêtre, France. Electronic address: peter.kamenicky@aphp.fr.
authors.forename: Peter
authors.initials: P
authors.lastname: Kamenický
authors.affiliation: Faculté de médecine, université Paris-Saclay, université Paris-Sud, 94275 Le Kremlin-Bicêtre, France.
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Lecoq
authors.affiliation: Inserm U1185, Le Kremlin-Bicêtre, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Chanson
mesh_terms: D000236:Adenoma / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D002118:Calcium / Q000378:metabolism; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D010282:Parathyroid Neoplasms / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D011247:Pregnancy / Q000502:physiology*; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy
chemical_list: D002118:Calcium
keywords: Complications maternelles et obstétricales; Gestation; Gestational; Grossesse; Hyperparathyroidism; Hyperparathyroïdisme; Maternal and obstetrical complications; Pregnancy