title: Successful medical management of a neonate with spontaneous splenic rupture and severe hemophilia A.
abstract: Splenic rupture in neonates is a rare event, usually occurring in the setting of underlying predisposing conditions. Here, we present the case of a term neonate who presented with worsening anemia in the setting of known hemolytic disease during the newborn period and was later found to have a spontaneous splenic rupture. He was subsequently diagnosed with severe hemophilia A, and was managed medically with recombinant factor VIII replacement therapy without any surgical intervention. This is the first reported case of a neonate who had spontaneous splenic rupture and severe hemophilia A, and underwent successful medical treatment without any surgical intervention.
authors.affiliation: Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Hematology, Oncology and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine at Zagazig University, Zagazig, Egypt. Electronic address: sbadawy@luriechildrens.org.
authors.forename: Sherif M
authors.initials: SM
authors.lastname: Badawy
authors.affiliation: Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Jenna
authors.initials: J
authors.lastname: Rossoff
authors.affiliation: Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Neonatology, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Sushmita
authors.initials: S
authors.lastname: Yallapragada
authors.affiliation: Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Hematology, Oncology and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Robert I
authors.initials: RI
authors.lastname: Liem
authors.affiliation: Department of Pediatrics, Division of Hematology, Oncology and Stem Cell Transplantation, University of Iowa Children's Hospital, Iowa City, IA, USA.
authors.forename: Anjali A
authors.initials: AA
authors.lastname: Sharathkumar
mesh_terms: D005169:Factor VIII / Q000627:therapeutic use; D006467:Hemophilia A / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012720:Severity of Illness Index; D013161:Splenic Rupture / Q000000981:diagnostic imaging / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: C577506:recombinant factor VIII N8; D005169:Factor VIII
keywords: Factor VIII deficiency; Hemophilia A; Neonate; Splenic rupture