title: Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial.
abstract: OBJECTIVE
  To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars.
  
  
  METHODS
  Twenty adolescents and adults with 2 impacted mandibular-third molars (in similar positions) were selected for the study. Patients were randomly assigned either to the IBU group (600 mg of IBU 3 times a day for 3 days) or to the ETO group (300 mg of ETO 3 times a day for 3 days). Drugs were administered immediately after dental extraction.
  
  
  RESULTS
  During the first 2 days after extraction, swelling was more pronounced in the IBU group than in the ETO group (P = .033). Seven days after surgery, there was no difference in the degree of edema between the groups. At the 2- and 7-day evaluation points, mouth opening was significantly more reduced in the IBU group than in the ETO group (P < .05). After the first 6 hours, the ETO group had more effective pain relief (P < .05), but after this time point, both groups reported similar degrees of relief. Compared with the IBU group, the ETO group had a lower need for administration of additional rescue analgesics.
  
  
  CONCLUSIONS
  After extraction of impacted lower third molars, we found that swelling, trismus, and pain were more effectively controlled with ETO than with IBU.
authors.affiliation: Resident, Maxillofacial Surgery Program, Araraquara Dental School, Universidade Estadual Paulista-UNESP, Araraquara, Brazil.
authors.forename: Júlio César
authors.initials: JC
authors.lastname: Silva de Oliveira
authors.affiliation: PhD Student, Department of Surgery and Integrated Clinic, Aracatuba Dental School, Universidade Estadual Paulista-UNESP, Aracatuba, Brazil. Electronic address: gustavo.grossi@yahoo.com.br.
authors.forename: Gustavo Augusto
authors.initials: GA
authors.lastname: Grossi de Oliveira
authors.affiliation: Assistant Professor, Department of Surgery and Integrated Clinic, Aracatuba Dental School, Universidade Estadual Paulista-UNESP, Aracatuba, Brazil.
authors.forename: Ana Paula Farnezi
authors.initials: AP
authors.lastname: Bassi
mesh_terms: D000293:Adolescent; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy*; D017308:Etodolac / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D008297:Male; D008334:Mandible / Q000601:surgery; D008964:Molar, Third / Q000601:surgery*; D059408:Pain Management; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D014081:Tooth Extraction; D014095:Tooth, Impacted / Q000601:surgery*; D016896:Treatment Outcome; D014313:Trismus / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D017308:Etodolac; D007052:Ibuprofen