title: Case of Primary Intraocular Lymphoma with Extraocular Extension.
abstract: OBJECTIVE
  To describe a case of primary intraocular lymphoma (PIOL) with an extension through the sclera that was confirmed to be part of the PIOL by histopathological examinations.
  
  
  METHODS
  An 89-year-old woman was referred to a local clinic with a 1-year history of persistent blurred vision in her left eye. After 2 years without aggressive treatments, she had a marked reduction of vision and pain in her left eye. The clinical diagnosis was panophthalmitis, and the eye was enucleated and submitted for histopathological study.
  
  
  RESULTS
  Light microscope examination showed that atypical lymphocytic cells had infiltrated into both the intraocular and extraocular areas. The anterior chamber angle was blocked by infiltrating tumor cells, which were also detected around the optic nerve. The tumor cells destroyed Bruch's membrane and infiltrated around the perineural and perivascular areas within the sclera. Immunohistochemistry showed that the tumor cells were positive for B-lymphocyte surface antigen (CD20), B-cell antigen receptor complex-associated protein alpha chain (CD79-alpha), and had a high positive rate for anti-Ki-67 antibody.
  
  
  CONCLUSIONS
  The finding in our case indicates that early diagnosis and treatment are important for eyes with PIOL because the tumor can spread and penetrate the sclera and invade extraocular tissues.
authors.affiliation: Department of Ophthalmology, Osaka, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Kuro
authors.affiliation: Department of Ophthalmology, Osaka, Japan.
authors.forename: Kayako
authors.initials: K
authors.lastname: Matsuyama
authors.affiliation: Department of Ophthalmology, Osaka, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Matsuoka
authors.affiliation: Kozaki Eye Clinic, Osaka, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Kosaki
authors.affiliation: Division of Diagnostic Cytopathology and Histopathology, Takii Hospital, Kansai Medical University, Moriguchi, Japan.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Shikata
authors.affiliation: Department of Ophthalmology, Osaka, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Nishimura
authors.affiliation: Department of Ophthalmology, Hirakata Hospital, Kansai Medical University, Hirakata, Japan.
authors.forename: Kanji
authors.initials: K
authors.lastname: Takahashi
keywords: Diffuse large B-cell lymphoma; Extraocular extension; Primary intraocular lymphoma; Secondary glaucoma