title: Analysis Suggests Drug Combos for Glioblastoma.
abstract: Researchers have shown that glioblastomas can develop resistance to a drug by rewiring their signaling networks to counteract its effects. Combining drugs that target two network changes produced remissions in mice implanted with human glioblastomas.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D019008:Drug Resistance, Neoplasm; D004359:Drug Therapy, Combination; D005909:Glioblastoma / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D051379:Mice; D058990:Molecular Targeted Therapy; D015398:Signal Transduction / Q000187:drug effects*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents