title: Ranolazine attenuated heightened plasma norepinephrine and B-Type natriuretic peptide-45 in improving cardiac function in rats with chronic ischemic heart failure.
abstract: As a new anti-anginal agent, ranolazinehas been shown to play a cardioprotective role in regulating myocardial ischemic injury. Given that plasma norepinephrine (NE) and brain natriuretic peptide (BNP, also termed B-type natriuretic peptide-45 in rats) are considered neuron-hormones to indicate heart failure progression. This study aims to examine effects of ranolazine on plasma NE and BNP-45 of rats with chronic ischemic heart failure (CHF). CHF was induced by myocardial infarction following ligation of a left anterior descending artery in adult Sprague-Dawley rats. We hypothesized that ranolazine attenuates the elevated levels of NE and BNP-45 observed in CHF rats thereby leading to improvement of the left ventricular function. Results showed that levels of plasma NE and BNP-45 were increased in CHF rats 6-8 weeks after ligation of the coronary artery. Our data demonstrate for the first time that ranolazine significantly attenuated the augmented NE and BNP-45 induced by CHF (P<0.05 vs. saline control). In addition, a liner relation was observed between NE/BNP-45levels and left ventricular fractional shortening as indication of left ventricular function (r=0.91 and P<0.01 for NE; and r=0.93 and P<0.01 for BNP-45) after administration of ranolazine. In conclusion, CHF increases the expression of NE and BNP-45 in peripheral circulation and these changes are related to the left ventricular function. Ranolazine improves the left ventricular function likely by decreasing heightened NE and BNP-45 induced by CHF. Therefore, our data indicate the role played by ranolazine in improving cardiac function in rats with CHF.
authors.affiliation: Department of Gerontology Xiangya Second Hospital of Central South UniversityChangsha 410011, China; Health Care Center, Hainan Provincial People HospitalHaikou 570311, China.
authors.forename: Guangqiu
authors.initials: G
authors.lastname: Feng
authors.affiliation: Department of Gerontology Xiangya Second Hospital of Central South University Changsha 410011, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Health Care Center, Hainan Provincial People Hospital Haikou 570311, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
authors.affiliation: Health Care Center, Hainan Provincial People Hospital Haikou 570311, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Health Care Center, Hainan Provincial People Hospital Haikou 570311, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Health Care Center, Hainan Provincial People Hospital Haikou 570311, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Health Care Center, Hainan Provincial People Hospital Haikou 570311, China.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Dai
authors.affiliation: Health Care Center, Hainan Provincial People Hospital Haikou 570311, China.
authors.forename: Pin
authors.initials: P
authors.lastname: Guan
authors.affiliation: Health Care Center, Hainan Provincial People Hospital Haikou 570311, China.
authors.forename: Chunrong
authors.initials: C
authors.lastname: Zhong
keywords: Ranolazine; brain natriuretic peptide; myocardial infarction; norepinephrine