title: Acute Tubulointerstitial Nephritis Associated with Infliximab in a Patient with Crohn's Disease.
abstract: We report the findings of a 46-year-old man, who presented with fever and renal dysfunction while undergoing treatment for Crohn's disease with infliximab (IFX). Remittent fever and renal dysfunction with urinary casts developed and lasted for 3 weeks without deterioration of Crohn's disease. Renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After the discontinuation of IFX, his fever and renal abnormalities resolved. We herein report the first known case of ATIN associated with IFX.
authors.affiliation: Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan.
authors.forename: Mineto
authors.initials: M
authors.lastname: Ota
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Iwai
authors.forename: Kaori
authors.initials: K
authors.lastname: Imai
authors.forename: Mari
authors.initials: M
authors.lastname: Kamiya
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yoshihashi-Nakazato
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Miyasaka
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kohsaka
mesh_terms: D003424:Crohn Disease / Q000188:drug therapy*; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D000069285:Infliximab / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology
chemical_list: D005765:Gastrointestinal Agents; D000069285:Infliximab