title: An Overview of the Efficacy of a Next Generation Electroceutical Wound Care Device.
abstract: Novel approaches including nonpharmacological methodologies for prevention and control of microbial pathogens and emerging antibiotic resistance are urgently needed. Procellera is a wound care device consisting of a matrix of alternating silver (Ag) and zinc (Zn) dots held in position on a polyester substrate with a biocompatible binder. This electroceutical medical device is capable of generating a direct current voltage (0.5-0.9 Volts). Wound dressings containing metals such as Ag and/or Zn as active ingredients are being used for control of colonized and infected wounds. Reports on the presence of electric potential field across epithelium and wound current on wounding have shown that wound healing is enhanced in the presence of an external electrical field. However, majority of the electrical devices require an external power source for delivering pulsed or continuous electric power at the wound site. A microelectric potential-generating system without an external power source is an ideal treatment modality for application in both clinical and field settings. The research presented herein describes efficacy evaluation of a wireless bioelectric dressing against both planktonic and biofilm forms of wound pathogens including multidrug resistant organisms.
authors.affiliation: Biosciences Division, Trideum Corporation, 4539 Metropolitan Court, Frederick, MD 21704.
authors.forename: Hosan
authors.initials: H
authors.lastname: Kim
authors.affiliation: Diagnostics and Translational Research Center, Henry M Jackson Foundation for the Advancement of Military Medicine, 401 Professional Drive, Gaithersburg, MD 20879.
authors.forename: Soon
authors.initials: S
authors.lastname: Park
authors.affiliation: United States Army Medical Material Agency, 504 Scott Street, Fort Detrick, Frederick, MD 21702.
authors.forename: Greggory
authors.initials: G
authors.lastname: Housler
authors.affiliation: Diagnostics and Translational Research Center, Henry M Jackson Foundation for the Advancement of Military Medicine, 401 Professional Drive, Gaithersburg, MD 20879.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Marcel
authors.affiliation: Diagnostics and Translational Research Center, Henry M Jackson Foundation for the Advancement of Military Medicine, 401 Professional Drive, Gaithersburg, MD 20879.
authors.forename: Sue
authors.initials: S
authors.lastname: Cross
authors.affiliation: Biosciences Division, Trideum Corporation, 4539 Metropolitan Court, Frederick, MD 21704.
authors.forename: Mina
authors.initials: M
authors.lastname: Izadjoo
mesh_terms: D001458:Bandages / Q000592:standards*; D018441:Biofilms; D053672:Electrochemotherapy / Q000379:methods* / Q000592:standards*; D006801:Humans; D011091:Polyesters / Q000008:administration & dosage / Q000627:therapeutic use; D012834:Silver / Q000627:therapeutic use; D014945:Wound Healing; D014946:Wound Infection / Q000517:prevention & control*; D015032:Zinc / Q000627:therapeutic use
chemical_list: D011091:Polyesters; D012834:Silver; D015032:Zinc