title: Greater hippocampal volume is associated with PTSD treatment response.
abstract: Previous research associates smaller hippocampal volume with posttraumatic stress disorder (PTSD). It is unclear, however, whether treatment affects hippocampal volume or vice versa. Seventy-six subjects, 40 PTSD patients and 36 matched trauma-exposed healthy resilient controls, underwent clinical assessments and magnetic resonance imaging (MRI) at baseline, and 10 weeks later, during which PTSD patients completed ten weeks of Prolonged Exposure (PE) treatment. The resilient controls and treatment responders (n=23) had greater baseline hippocampal volume than treatment non-responders (n=17) (p=0.012 and p=0.050, respectively), perhaps due to more robust fear-extinction capacity in both the initial phase after exposure to trauma and during treatment.
authors.affiliation: New York State Psychiatric Institute, New York, USA.
authors.forename: Mikael
authors.initials: M
authors.lastname: Rubin
authors.affiliation: New York State Psychiatric Institute, New York, USA.
authors.forename: Erel
authors.initials: E
authors.lastname: Shvil
authors.affiliation: New York State Psychiatric Institute, New York, USA.
authors.forename: Santiago
authors.initials: S
authors.lastname: Papini
authors.affiliation: New York State Psychiatric Institute, New York, USA.
authors.forename: Binod T
authors.initials: BT
authors.lastname: Chhetry
authors.affiliation: New York State Psychiatric Institute, New York, USA.
authors.forename: Liat
authors.initials: L
authors.lastname: Helpman
authors.affiliation: New York State Psychiatric Institute, New York, USA; Columbia University Medical Center, College of Physicians & Surgeons, New York, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Markowitz
authors.affiliation: New York State Psychiatric Institute, New York, USA; Columbia University Medical Center, College of Physicians & Surgeons, New York, USA.
authors.forename: J John
authors.initials: JJ
authors.lastname: Mann
authors.affiliation: New York State Psychiatric Institute, New York, USA; Columbia University Medical Center, College of Physicians & Surgeons, New York, USA. Electronic address: ny126@cumc.columbia.edu.
authors.forename: Yuval
authors.initials: Y
authors.lastname: Neria
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005239:Fear / Q000187:drug effects; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D013313:Stress Disorders, Post-Traumatic / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D013997:Time Factors; D016896:Treatment Outcome
keywords: Hippocampus; MRI; PTSD; Prolonged Exposure Treatment; Resilience; Treatment Response