title: [DIURETIC ACTIVITY OF 4-O-CARBOXYPHENYL-D-GLUCOPYRANOSIDE SODIUM SALT ADMINISTERED VIA DIFFERENT ROUTES].
abstract: It was compared the diuretic activity of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid for enteral (intragastric) and parenteral ways of administration. The test substance was administered enterally and parenterally (subcutaneously in the region of the withers) in a daily dose of 18 µmol/kg for the first seven days and in a dose of 54 mmol/kg for the next seven days. Diuretic activity of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid was evaluated in terms of urine volume. Urine was analyzed for creatinine and the concentration of sodium, potassium and chloride ions. Experiments showed that the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid produced a diuretic effect only for the enteral administration route.
authors.forename: I V
authors.initials: IV
authors.lastname: Smirnov
authors.forename: T O
authors.initials: TO
authors.lastname: Murashko
authors.forename: A A
authors.initials: AA
authors.lastname: Ivanov
authors.forename: A O
authors.initials: AO
authors.lastname: Nemtsev
authors.forename: P S
authors.initials: PS
authors.lastname: Postnikov
authors.forename: A A
authors.initials: AA
authors.lastname: Bondarev
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
mesh_terms: D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D003404:Creatinine / Q000652:urine; D004232:Diuretics / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D011188:Potassium / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000652:urine
chemical_list: D001565:Benzoates; D004232:Diuretics; D012964:Sodium; D003404:Creatinine; D011188:Potassium