title: Insulin-Like Growth Factors (IGF) and IGF-Binding Proteins (IGFBP) in the Serum of Patients with Ovarian Tumors.
abstract: IGF-1, IGF-2, and IGFBP-1,2,3 were assayed in blood serum of patients with malignant ovarian tumors (n=44), borderline ovarian tumors (n=11), and benign ovarian tumors (n=12) as well as in healthy women (n=33). In blood serum of patients with malignant ovarian tumors, the level of IGF-1 was lower and IGFBP-1 was higher than in other groups. In patients with malignant and borderline ovarian tumors, the level of IGFBP-2 was higher than in healthy women and in patients with benign ovarian tumors. There was no correlation between most examined parameters and the clinical and morphological peculiarities of ovarian tumors. The study revealed IGF/IGFBP imbalance in patients with malignant ovarian tumor and showed that IGFBP-2 proved to be a potential diagnostic serological marker w with 90% sensitivity and 90% specificity.
authors.affiliation: V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia. biochimia@mtu-net.ru.
authors.forename: E S
authors.initials: ES
authors.lastname: Gershtein
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: E R
authors.initials: ER
authors.lastname: Isaeva
authors.affiliation: V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: D N
authors.initials: DN
authors.lastname: Kushlinsky
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Korotkova
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: V D
authors.initials: VD
authors.lastname: Ermilova
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: K P
authors.initials: KP
authors.lastname: Laktionov
authors.affiliation: V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Adamyan
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000097:blood*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; C583557:IGF1 protein, human; C035170:IGF2 protein, human; C032231:IGFBP1 protein, human; C577903:IGFBP2 protein, human; C515497:IGFBP3 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D018971:Insulin-Like Growth Factor Binding Protein 2; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II
keywords: IGF-binding proteins IGFBP-1, 2, 3; insulin-like growth factors IGF-1 and IGF-2; ovarian tumors