title: Prognostic Value of Cardiovascular Magnetic Resonance and Single-Photon Emission Computed Tomography in Suspected Coronary Heart Disease: Long-Term Follow-up of a Prospective, Diagnostic Accuracy Cohort Study.
abstract: BACKGROUND
  There are no prospective, prognostic data comparing cardiovascular magnetic resonance (CMR) and single-photon emission computed tomography (SPECT) in the same population of patients with suspected coronary heart disease (CHD).
  
  
  OBJECTIVE
  To establish the ability of CMR and SPECT to predict major adverse cardiovascular events (MACEs).
  
  
  METHODS
  Annual follow-up of the CE-MARC (Clinical Evaluation of MAgnetic Resonance imaging in Coronary heart disease) study for a minimum of 5 years for MACEs (cardiovascular death, acute coronary syndrome, unscheduled revascularization or hospital admission for cardiovascular cause). (Current Controlled Trials registration: ISRCTN77246133).
  
  
  METHODS
  Secondary and tertiary care cardiology services.
  
  
  METHODS
  752 patients from the CE-MARC study who were being investigated for suspected CHD.
  
  
  METHODS
  Prediction of time to MACE was assessed by using univariable (log-rank test) and multivariable (Cox proportional hazards regression) analysis.
  
  
  RESULTS
  744 (99%) of the 752 recruited patients had complete follow-up. Of 628 who underwent CMR, SPECT, and the reference standard test of X-ray angiography, 104 (16.6%) had at least 1 MACE. Abnormal findings on CMR (hazard ratio, 2.77 [95% CI, 1.85 to 4.16]; P < 0.001) and SPECT (hazard ratio, 1.62 [CI, 1.11 to 2.38; P = 0.014) were both strong and independent predictors of MACE. Only CMR remained a significant predictor after adjustment for other cardiovascular risk factors, angiography result, or stratification for initial patient treatment.
  
  
  CONCLUSIONS
  Data are from a single-center observational study (albeit conducted in a high-volume institution for both CMR and SPECT).
  
  
  CONCLUSIONS
  Five-year follow-up of the CE-MARC study indicates that compared with SPECT, CMR is a stronger predictor of risk for MACEs, independent of cardiovascular risk factors, angiography result, or initial patient treatment. This further supports the role of CMR as an alternative to SPECT for the diagnosis and management of patients with suspected CHD.
  
  
  BACKGROUND
  British Heart Foundation.
authors.forename: John P
authors.initials: JP
authors.lastname: Greenwood
authors.forename: Bernhard A
authors.initials: BA
authors.lastname: Herzog
authors.forename: Julia M
authors.initials: JM
authors.lastname: Brown
authors.forename: Colin C
authors.initials: CC
authors.lastname: Everett
authors.forename: Jane
authors.initials: J
authors.lastname: Nixon
authors.forename: Petra
authors.initials: P
authors.lastname: Bijsterveld
authors.forename: Neil
authors.initials: N
authors.lastname: Maredia
authors.forename: Manish
authors.initials: M
authors.lastname: Motwani
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Dickinson
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Ball
authors.forename: Sven
authors.initials: S
authors.lastname: Plein