title: Conversion from MCI to AD in patients with the APOE ε4 genotype: Prediction by plasma HCY and serum BDNF.
abstract: Amnestic mild cognitive impairment (aMCI) is a transitional stage between normal aging and Alzheimer's disease (AD). Possession of the apolipoprotein E (APOE) ε4 genotype is a major predictor of progression to AD, particularly in patients with aMCI. However, the use of APOE genotyping in the diagnosis of aMCI that evolves into AD is limited due to its low sensitivity and specificity. In this study, we found that there was a notable increase in plasma homocysteine (HCY) and significant decrease in serum brain-derived neurotrophic factor (BDNF) in aMCI that converts to AD in patients with the APOE ε4 allele. Both plasma HCY and serum BDNF had higher positive predictive values and were more sensitive biomarkers of aMCI. Additionally, a testing strategy employing plasma HCY and serum BDNF revealed increases in sensitivity, specificity, and predictive ability compared with the use of either biomarker alone. The present study demonstrates that MCI that evolves into AD in patients with the APOE ε4 genotype may be predicted by plasma HCY and serum BDNF.
authors.affiliation: Central Laboratory, Harrison International Peace Hospital, Hengshui, Hebei, China. Electronic address: leinick@163.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Central Laboratory, Cangzhou central Hospital, Cangzhou, Hebei, China.
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Kong
authors.affiliation: Department of Neurology, Harrison International Peace Hospital, Hengshui, Hebei, China.
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Department of Neurology, Harrison International Peace Hospital, Hengshui, Hebei, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Neurology, Harrison International Peace Hospital, Hengshui, Hebei, China.
authors.forename: Jinrong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Second Department of Orthopedics, Harrison International Peace Hospital, Hengshui, Hebei, China. Electronic address: weiwei6662@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism*; D053327:Apolipoprotein E4 / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D060825:Cognitive Dysfunction / Q000235:genetics / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D005838:Genotype; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D012680:Sensitivity and Specificity
chemical_list: D053327:Apolipoprotein E4; D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D006710:Homocysteine; C579455:BDNF protein, human
keywords: AD; APOE ε4; BDNF; HCY; aMCI