title: Noncorticosteroid Combination Shampoo versus 1% Ketoconazole Shampoo for the Management of Mild-to-Moderate Seborrheic Dermatitis of the Scalp: Results from a Randomized, Investigator-Single-Blind Trial Using Clinical and Trichoscopic Evaluation.
abstract: OBJECTIVE
  The aim of this study was to assess the efficacy and tolerability of a combination noncorticosteroid, antiinflammatory/antifungal shampoo versus 1% ketoconazole shampoo in the treatment of mild-to-moderate scalp seborrheic dermatitis (SD).
  
  
  METHODS
  Twenty patients were randomized to using the combination shampoo (group A, 10 patients) or the 1% ketoconazole shampoo (group B, 10 patients) 3 times a week every other day for 8 weeks. Efficacy was evaluated by measuring the degree of scaling and pruritus by clinical and trichoscopic examination using a 4-point scale. Additionally, a physician global assessment (PGA) was assessed at the end of the study.
  
  
  RESULTS
  At 4 weeks, there was a significant reduction of scaling from baseline for both groups, while pruritus showed a significant reduction only for group A. After 8 weeks, there was a significant reduction of scaling and pruritus for both groups. PGA showed a complete response in 90% of the cases in both groups.
  
  
  CONCLUSIONS
  The results of our study demonstrate that the combination noncorticosteroid, antiinflammatory/antifungal shampoo represents an alternative approach to standard topical treatment for scalp SD. A noncorticosteroid shampoo may be equally safe and effective as ketoconazole shampoo for scalp SD, and trichoscopy provides accurate and reliable quantifiable data to assist in therapeutic monitoring.
authors.affiliation: Dermatology Clinic, University of Catania, Catania, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Dall'Oglio
authors.affiliation: Dermatology Clinic, University of Catania, Catania, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Lacarrubba
authors.affiliation: Dermatology Clinic, University of Catania, Catania, Italy.
authors.forename: Anna Elisa
authors.initials: AE
authors.lastname: Verzì
authors.affiliation: Dermatology Clinic, University of Catania, Catania, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Micali
keywords: Antifungal shampoo; Antiinflammatory shampoo; Ketoconazole; Scalp; Seborrheic dermatitis; Topical treatment; Trichoscopy