title: The 2011-2012 pilot European Society of Cardiology Sentinel Registry of Transcatheter Aortic Valve Implantation: 12-month clinical outcomes.
abstract: OBJECTIVE
  Our aim was to assess one-year outcomes of patients enrolled in the pilot European Sentinel Registry of Transcatheter Aortic Valve Implantation (TAVI).
  
  
  RESULTS
  One-year outcomes of 4,571 patients (81.4±7.2 years, 2,291 [50.1%] male) receiving TAVI with the SAPIEN XT (57.3%) or CoreValve prosthesis at 137 European centres were analysed using Kaplan-Meier and Cox proportional hazards regression techniques. At one year, 3,341 patients were alive, 821 had died, and 409 were lost to follow-up. Of 2,125 patients who underwent functional assessment, 1,916 (90%) were in New York Heart Association (NYHA) Class I/II at one year, with functional improvement from baseline noted in 1,682 patients (88%). One-year survival based on 4,564 patients was estimated at 79.1%. Independent baseline predictors of mortality were increasing age and logistic EuroSCORE, the presence of NYHA III/IV, chronic obstructive pulmonary disease, and atrial fibrillation. Female gender was associated with a 4% survival benefit at one year. Vascular access routes other than transfemoral were associated with poorer survival. Procedural failure and major periprocedural complications had an adverse impact on survival.
  
  
  CONCLUSIONS
  Contemporary European experience attests to the effectiveness of routine TAVI in unselected elderly patients.
authors.affiliation: Centre Hospitalier Universitaire (CHU) Brest, Brest, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Gilard
authors.forename: Michael
authors.initials: M
authors.lastname: Schlüter
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Snow
authors.forename: Gianni
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authors.lastname: Dall'Ara
authors.forename: Helene
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authors.lastname: Eltchaninoff
authors.forename: Neil
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authors.lastname: Moat
authors.forename: Javier
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authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Ussia
authors.forename: Petr
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authors.lastname: Wenaweser
authors.forename: Marian
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authors.lastname: Zembala
authors.forename: Georg
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authors.lastname: Nickenig
authors.forename: Susanna
authors.initials: S
authors.lastname: Price
authors.forename: Eduardo
authors.initials: E
authors.lastname: Alegria Barrero
authors.forename: Bernard
authors.initials: B
authors.lastname: Iung
authors.forename: Pepe
authors.initials: P
authors.lastname: Zamorano
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schuler
authors.forename: Roberto
authors.initials: R
authors.lastname: Corti
authors.forename: Ottavio
authors.initials: O
authors.lastname: Alfieri
authors.forename: Bernard
authors.initials: B
authors.lastname: Prendergast
authors.forename: Peter
authors.initials: P
authors.lastname: Ludman
authors.forename: Stephan
authors.initials: S
authors.lastname: Windecker
authors.forename: Manel
authors.initials: M
authors.lastname: Sabate
authors.forename: Adam
authors.initials: A
authors.lastname: Witkowski
authors.forename: Haim
authors.initials: H
authors.lastname: Danenberg
authors.forename: Erwin
authors.initials: E
authors.lastname: Schroeder
authors.forename: Francesco
authors.initials: F
authors.lastname: Romeo
authors.forename: Carlos
authors.initials: C
authors.lastname: Macaya
authors.forename: Geneviève
authors.initials: G
authors.lastname: Derumeaux
authors.forename: Cécile
authors.initials: C
authors.lastname: Laroche
authors.forename: Michele
authors.initials: M
authors.lastname: Pighi
authors.forename: Roberta
authors.initials: R
authors.lastname: Serdoz
authors.forename: Carlo
authors.initials: C
authors.lastname: Di Mario
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000601:surgery*; D006328:Cardiac Catheterization / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006801:Humans; D008297:Male; D000070356:Pilots; D011183:Postoperative Complications / Q000453:epidemiology; D012042:Registries; D012307:Risk Factors; D065467:Transcatheter Aortic Valve Replacement / Q000379:methods; D016896:Treatment Outcome