title: In-stem thiazole orange reveals the same triplex intermediate for pH and thermal unfolding of i-motifs.
abstract: The unfolding pathway of human telomeric i-motifs was monitored by both monomer and exciplex fluorescence of in-stem thiazole orange. A uniform triplex intermediate was observed upon unfolding i-motifs against either pH or thermal denaturation.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore. fwshao@ntu.edu.sg.
authors.forename: Gitali
authors.initials: G
authors.lastname: Devi
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore. fwshao@ntu.edu.sg.
authors.forename: Lei
authors.initials: L
authors.lastname: He
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore. fwshao@ntu.edu.sg.
authors.forename: Baochang
authors.initials: B
authors.lastname: Xu
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore. fwshao@ntu.edu.sg.
authors.forename: Tianhu
authors.initials: T
authors.lastname: Li
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore. fwshao@ntu.edu.sg.
authors.forename: Fangwei
authors.initials: F
authors.lastname: Shao
mesh_terms: D001483:Base Sequence; D052160:Benzothiazoles / Q000737:chemistry*; D002942:Circular Dichroism; D003596:Cytosine / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009690:Nucleic Acid Conformation; D011804:Quinolines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D016615:Telomere / Q000737:chemistry*; D044366:Transition Temperature
chemical_list: D052160:Benzothiazoles; D011804:Quinolines; C051000:thiazole orange; D003596:Cytosine