title: Findings from a pilot Randomised trial of an Asthma Internet Self-management Intervention (RAISIN).
abstract: To evaluate the feasibility of a phase 3 randomised controlled trial (RCT) of a website (Living Well with Asthma) to support self-management.
  
  
  
  Phase 2, parallel group, RCT, participants recruited from 20 general practices across Glasgow, UK. Randomisation through automated voice response, after baseline data collection, to website access for minimum 12 weeks or usual care.
  
  
  
  Adults (age≥16 years) with physician diagnosed, symptomatic asthma (Asthma Control Questionnaire (ACQ) score ≥1). People with unstable asthma or other lung disease were excluded.
  
  
  
  'Living Well with Asthma' is a desktop/laptop compatible interactive website designed with input from asthma/ behaviour change specialists, and adults with asthma. It aims to support optimal medication management, promote use of action plans, encourage attendance at asthma reviews and increase physical activity.
  
  
  
  Primary outcomes were recruitment/retention, website use, ACQ and mini-Asthma Quality of Life Questionnaire (AQLQ). Secondary outcomes included patient activation, prescribing, adherence, spirometry, lung inflammation and health service contacts after 12 weeks. Blinding postrandomisation was not possible.
  
  
  
  Recruitment target met. 51 participants randomised (25 intervention group). Age range 16-78 years; 75% female; 28% from most deprived quintile. 45/51 (88%; 20 intervention group) followed up. 19 (76% of the intervention group) used the website, for a mean of 18 min (range 0-49). 17 went beyond the 2 'core' modules. Median number of logins was 1 (IQR 1-2, range 0-7). No significant difference in the prespecified primary efficacy measures of ACQ scores (-0.36; 95% CI -0.96 to 0.23; p=0.225), and mini-AQLQ scores (0.38; -0.13 to 0.89; p=0.136). No adverse events.
  
  
  
  Recruitment and retention confirmed feasibility; trends to improved outcomes suggest use of Living Well with Asthma may improve self-management in adults with asthma and merits further development followed by investigation in a phase 3 trial.
  
  
  
  ISRCTN78556552; Results.
authors.affiliation: General Practice & Primary Care, Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.
authors.forename: D
authors.initials: D
authors.lastname: Morrison
authors.affiliation: Institute of Health and Wellbeing/Interdisciplinary Research Professor, College of Social Sciences, University of Glasgow, Glasgow, UK.
authors.forename: S
authors.initials: S
authors.lastname: Wyke
authors.affiliation: General Practice & Primary Care, Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.
authors.forename: K
authors.initials: K
authors.lastname: Saunderson
authors.affiliation: Institute of Health and Wellbeing/Interdisciplinary Research Professor, College of Social Sciences, University of Glasgow, Glasgow, UK Robertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
authors.forename: A
authors.initials: A
authors.lastname: McConnachie
authors.affiliation: General Practice & Primary Care, Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.
authors.forename: K
authors.initials: K
authors.lastname: Agur
authors.affiliation: Institute of Infection, Immunity and Inflammation, Gartnavel General Hospital, University of Glasgow, Glasgow, UK.
authors.forename: R
authors.initials: R
authors.lastname: Chaudhuri
authors.affiliation: Primary Care Research, Aldermoor Health Centre, University of Southampton, Southampton, UK.
authors.forename: M
authors.initials: M
authors.lastname: Thomas
authors.affiliation: Institute of Infection, Immunity and Inflammation, Gartnavel General Hospital, University of Glasgow, Glasgow, UK.
authors.forename: N C
authors.initials: NC
authors.lastname: Thomson
authors.affiliation: Department of Psychology, University of Southampton, Southampton, UK.
authors.forename: L
authors.initials: L
authors.lastname: Yardley
authors.affiliation: General Practice & Primary Care, Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.
authors.forename: F S
authors.initials: FS
authors.lastname: Mair
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control*; D001993:Bronchodilator Agents / Q000008:administration & dosage; D015444:Exercise; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D020407:Internet / Q000706:statistics & numerical data*; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D018579:Patient Selection; D010865:Pilot Projects; D011239:Prednisolone / Q000008:administration & dosage; D011788:Quality of Life; D012648:Self Care; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; D011239:Prednisolone
keywords: Adherence; Internet; PRIMARY CARE; behaviour change; complex intervention