title: A Comparison of Mindray BC-6800, Sysmex XN-2000, and Beckman Coulter LH750 Automated Hematology Analyzers: A Pediatric Study.
abstract: BACKGROUND
  Modern automated laboratory hematology analyzers allow the measurement of over 30 different hematological parameters useful in the diagnostic and clinical interpretation of patient symptoms. They use different methods to measure the same parameters. Thus, a comparison of complete blood count made by Mindray BC-6800, Sysmex XN-2000 and Beckman Coulter LH750 was performed.
  
  
  METHODS
  A comparison of results obtained by automated analysis of 807 anticoagulated blood samples from children and 125 manual microscopic differentiations were performed. This comparative study included white blood cell count, red blood cell count, and erythrocyte indices, as well as platelet count.
  
  
  RESULTS
  The present study showed a poor level of agreement between white blood cell enumeration and differentiation of the three automated hematology analyzers under comparison. A very good agreement was found when comparing manual blood smear and automated granulocytes, monocytes, and lymphocytes differentiation. Red blood cell evaluation showed better agreement than white blood cells between the studied analyzers.
  
  
  CONCLUSIONS
  To conclude, studied instruments did not ensure satisfactory interchangeability and did not facilitate a substitution of one analyzer by another.
authors.affiliation: Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland. olga.ciepiela@wum.edu.pl.
authors.forename: Olga
authors.initials: O
authors.lastname: Ciepiela
authors.affiliation: Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Kotuła
authors.affiliation: Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Pediatric Hospital of Medical University of Warsaw, Warsaw, Poland.
authors.forename: Szymon
authors.initials: S
authors.lastname: Kierat
authors.affiliation: Student Scientific Group at Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Sandra
authors.initials: S
authors.lastname: Sieczkowska
authors.affiliation: Student Scientific Group at Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Podsiadłowska
authors.affiliation: Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Pediatric Hospital of Medical University of Warsaw, Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Jenczelewska
authors.affiliation: Student Scientific Group at Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Karolina
authors.initials: K
authors.lastname: Księżarczyk
authors.affiliation: Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Urszula
authors.initials: U
authors.lastname: Demkow
mesh_terms: D000293:Adolescent; D057205:Automation, Laboratory; D001772:Blood Cell Count / Q000295:instrumentation* / Q000379:methods*; D001773:Blood Cells / Q000166:cytology / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D004906:Erythrocyte Count; D005260:Female; D006405:Hematology / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D010976:Platelet Count; D012044:Regression Analysis; D015203:Reproducibility of Results
keywords: automated hematology analyzer; comparison; complete blood count; pediatric hematology