title: Swelling, mechanical and friction properties of PVA/PVP hydrogels after swelling in osmotic pressure solution.
abstract: The potential of polyvinyl alcohol/polyvinylpyrrolidone (PVA/PVP) hydrogels as articular cartilage replacements was in vitro evaluated by using a macromolecule-based solution to mimic the osmotic environment of cartilage tissue. The effects of osmotic pressure solution on the morphology, crystallinity, swelling, mechanical and friction properties of PVA/PVP hydrogels were investigated by swelling them in non-osmotic and osmotic pressure solutions. The results demonstrated that swelling ratio and equilibrium water content were greatly reduced by swelling in osmotic solution, and the swelling process was found to present pseudo-Fickian diffusion character. The crystallization degree of hydrogels after swelling in osmotic solution increased more significantly when it compared with that in non-osmotic solution. After swelling in osmotic solution for 28days, the compressive tangent modulus and storage modulus of hydrogels were significantly increased, and the low friction coefficient was reduced. However, after swelling in the non-osmotic solution, the compressive tangent modulus and friction coefficient of hydrogels were comparable with those of as-prepared hydrogels. The better material properties of hydrogels in vivo than in vitro evaluation demonstrated their potential application in cartilage replacement.
authors.affiliation: School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.affiliation: School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, PR China; Jiangsu Key Laboratory of Advanced Micro/nano Materials and Technology, Nanjing, Jiangsu 210094, PR China. Electronic address: xiongds@163.com.
authors.forename: Dangsheng
authors.initials: D
authors.lastname: Xiong
authors.affiliation: School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, PR China.
authors.forename: Yuntong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, PR China.
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.affiliation: School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, PR China.
authors.forename: Xiaoduo
authors.initials: X
authors.lastname: Zhao
mesh_terms: D002152:Calorimetry, Differential Scanning; D019245:Compressive Strength; D020100:Hydrogels / Q000737:chemistry*; D009997:Osmotic Pressure; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D012212:Rheology; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D020100:Hydrogels; D011142:Polyvinyl Alcohol; D011205:Povidone
keywords: Friction coefficient; Mechanical properties; Osmotic pressure; PVA/PVP hydrogel; Swelling