title: Genetic Instability in Locus rs5498 E469K (A/G) of ICAM-1 Gene in Patients with Colorectal Cancer and Breast Cancer.
abstract: Single-nucleotide polymorphism rs5498 E469K (A/G) in ICAM-1 gene modulates functional activity of this protein and is associated with the risk of some diseases. Tumor cell rs5498 E469K (A/G) genotypes were compared with genotypes of patients with colorectal and breast cancer, residents of the Nizhniy Novgorod region. Specimens of peripheral blood and tumor foci from patients with colorectal and breast cancer and peripheral blood specimens from normal subjects were analyzed. The frequency of genotypes of single-nucleotide rs5498 E469K (A/G) sequence in the Nizhny Novgorod population coincide with the frequency of genotypes characteristic of residents of Germany. Comparison of genotypes of peripheral blood and tumor cells from patients with colorectal and breast cancer showed loss of cancer cell heterozygosity. The frequency of heterozygosity loss increases with colorectal cancer progress from one stage to another.
authors.affiliation: National Research University, N. I. Lobachevsky Nizhny Novgorod University, Nizhny Novgorod, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Novikov
authors.affiliation: National Research University, N. I. Lobachevsky Nizhny Novgorod University, Nizhny Novgorod, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Shumilova
authors.affiliation: National Research University, N. I. Lobachevsky Nizhny Novgorod University, Nizhny Novgorod, Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Novikov
authors.affiliation: National Research University, N. I. Lobachevsky Nizhny Novgorod University, Nizhny Novgorod, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kalugin
authors.affiliation: National Research University, N. I. Lobachevsky Nizhny Novgorod University, Nizhny Novgorod, Russia.
authors.forename: S G
authors.initials: SG
authors.lastname: Fomina
authors.affiliation: National Research University, N. I. Lobachevsky Nizhny Novgorod University, Nizhny Novgorod, Russia. drkaraulov@mail.ru.|I. M. Sechenov First Moscow State Medical University, Moscow, Russia. drkaraulov@mail.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Karaulov
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D043171:Chromosomal Instability; D015179:Colorectal Neoplasms / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D005858:Germany; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D018799:Intercellular Adhesion Molecule-1
keywords: ICAM-1; breast cancer; colorectal cancer; heterozygosity loss; single-nucleotide polymorphism