title: Prenatal triclosan exposure and cord blood immune system biomarkers.
abstract: Triclosan is widely used as an antimicrobial agent and preservative that has been hypothesized to play a role in asthma and allergic disease. The limited body of literature regarding the allergenicity of triclosan has not evaluated prenatal exposure and subsequent potential effects on the developing immune system. The objective of the present study was to determine the association between prenatal urinary triclosan concentrations and cord blood immune system biomarker concentrations. Umbilical cord blood samples were obtained from the Maternal-Infant Research on Environmental Chemicals (MIREC) Biobank and were tested for three immune system biomarkers: immunoglobulin E (IgE), thymic stromal lymphopoietin (TSLP), and interleukin-33 (IL-33). Triclosan concentrations were measured in urine at 6-13 weeks gestation. No statistically significant associations were observed between prenatal triclosan concentrations and elevated concentrations of any immune system biomarker (n=1219 participants). Longitudinal studies are necessary to determine how the observed findings at birth translate into childhood.
authors.affiliation: Perinatal Epidemiology Research Unit, Departments of Obstetrics & Gynecology and Pediatrics, Dalhousie University, Halifax, NS B3K 6R8, Canada. Electronic address: jillian.ashley-martin@dal.ca.
authors.forename: Jillian
authors.initials: J
authors.lastname: Ashley-Martin
authors.affiliation: Perinatal Epidemiology Research Unit, Departments of Obstetrics & Gynecology and Pediatrics, Dalhousie University, Halifax, NS B3K 6R8, Canada. Electronic address: l.dodds@dal.ca.
authors.forename: Linda
authors.initials: L
authors.lastname: Dodds
authors.affiliation: Population Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON K1A 0K9, Canada. Electronic address: tye.arbuckle@hc-sc.gc.ca.
authors.forename: Tye E
authors.initials: TE
authors.lastname: Arbuckle
authors.affiliation: Department of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada. Electronic address: jean.marshall@dal.ca.
authors.forename: Jean
authors.initials: J
authors.lastname: Marshall
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000652:urine*; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000652:urine*; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D000067596:Interleukin-33 / Q000097:blood; D018811:Maternal Exposure; D016017:Odds Ratio; D011247:Pregnancy; D014260:Triclosan / Q000652:urine*; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D000891:Anti-Infective Agents, Local; D015415:Biomarkers; D016207:Cytokines; D004785:Environmental Pollutants; C506536:IL33 protein, human; D000067596:Interleukin-33; D007073:Immunoglobulin E; D014260:Triclosan; D000094632:Thymic Stromal Lymphopoietin
keywords: Birth cohort; Immune system development; Pregnancy; Triclosan