title: Remitted epilepsy with dysembryoplastic neuroepithelial tumor involving the thalamus.
abstract: Dysembryoplastic neuroepithelial tumors (DNT) are benign hamartomatous tumors characterized by intractable epilepsy and common localization in the supratentorial cortex, but thalamic involvement in DNT is extremely rare. A 2-year 4-month-old boy presented with intractable epilepsy due to a tumorous lesion in the frontal lobe expanding to the thalamus. Under chronic intracranial electrocorticography guidance, partial lesionectomy with adjacent cortical resection was performed, and the lesion was pathologically diagnosed as DNT, complex form. Subsequently, the seizures completely disappeared without any neurological deficits despite the presence of full residual thalamic lesions. The epileptogenicity of DNT is closely associated with various clinicopathological factors, and the thalamic contribution to the seizure activity remains unclear. Due to the essential epileptogenic characteristics of DNT, the residual thalamic lesions and associated clinical features should be strictly observed in the future in the present case.
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.|Department of Developmental and Behavioral Pediatrics, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Nishikura
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Takano
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Fukiko
authors.initials: F
authors.lastname: Ryujin
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Yoshioka
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Maruo
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.|Department of Developmental and Behavioral Pediatrics, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takeuchi
authors.affiliation: Department of Neurosurgery, Nara Medical University, Kashihara, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Tamura
authors.affiliation: Department of Pediatrics, Nara Medical University, Kashihara, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Sakakibara
authors.affiliation: Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ito
keywords: children; dysembryoplastic neuroepithelial tumor; epilepsy surgery; intractable epilepsy; thalamus