title: Association between glutathione S-transferase M1/T1 gene polymorphisms and susceptibility to endometriosis: A systematic review and meta-analysis.
abstract: Endometriosis is a polygenic/multifactorial disease caused by interactions between multiple genes and the environment. Findings from studies evaluating the association between the glutathione S-transferase (GST) M1/T1 null genotype and susceptibility to endometriosis are inconsistent. This meta-analysis updated and reevaluated the possible associations betweenGSTM1,GSTT1and combinedGSTM1/GSTT1(null genotype versus wild-type) gene polymorphisms and susceptibility to endometriosis. The PubMed, Embase and Chinese BioMedical Literature databases and Google Scholar were searched for case-control genetic association studies onGSTM1/GSTT1(null genotype versus wild-type) gene polymorphisms and endometriosis in comparison with non-endometriosis or healthy controls. Fixed-effect and random-effect meta-analytical techniques were conducted for the outcome measure and subgroup analyses. The meta-analysis demonstrated significant associations between theGSTM1[odds ratio (OR)=1.56; 95% confidence interval (CI): 1.25-1.95; P<0.0001),GSTT1(OR=1.31; 95% CI: 1.02-1.68; P=0.037) andGSTM1/GSTT1(OR=1.68; 95% CI: 1.29-2.17; P<0.0001) null genotypes and increased risk for endometriosis. The results suggest that theGSTM1,GSTT1, and combinedGSTM1/GSTT1null genotypes increase susceptibility to endometriosis. Additional well-designed studies and precise analyses are warranted to confirm these findings.
authors.affiliation: Department of Gynecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Xin
authors.affiliation: Department of Gynecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
authors.forename: Zhishan
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Department of General Surgery, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou 550001, P.R. China.
authors.forename: Huajian
authors.initials: H
authors.lastname: Gu
authors.affiliation: Department of Gynecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
authors.forename: Yuanyue
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Gynecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Wu
authors.affiliation: Department of Gynecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
authors.forename: Teng
authors.initials: T
authors.lastname: Hua
authors.affiliation: Department of Gynecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Wang
keywords: endometriosis; gene polymorphisms; glutathione S-transferase M1; glutathione S-transferase T1; meta-analysis