title: Hydrogen bonding and anticancer properties of water-soluble chiralp-cymene Ru(II) compounds with amino-oxime ligands.
abstract: The investigation of the hydrogen-bonding effect on the aggregation tendency of ruthenium compounds [(η6-p-cymene)Ru(κNHR,κNOH)Cl]Cl (R = Ph (1a), Bn (1b)) and [(η6-p-cymene)Ru(κ2NH(2-pic),κNOH)][PF6]2(1c), [(η6-p-cymene)Ru(κNHBn,κNO)Cl] (2b) and [(η6-p-cymene)Ru(κNBn,κ2NO)] (3b), has been performed by means of concentration dependence1H NMR chemical shifts and DOSY experiments. The synthesis and full characterization of new compounds1c, [(η6-p-cymene)Ru(κNPh,κ2NO)] (3a) and3bare also reported. The effect of the water soluble ruthenium complexes1a-1con cytotoxicity, cell adhesion and cell migration of the androgen-independent prostate cancer PC3 cells have been assessed by MTT, adhesion to type-I-collagen and recovery of monolayer wounds assays, respectively. Interactions of1a-1cwith DNA and human serum albumin have also been studied. Altogether, the properties reported herein suggest that ruthenium compounds1a-1chave considerable potential as anticancer agents against advanced prostate cancer.
authors.affiliation: Departamento de Química Orgánica y Química Inorgánica, Facultad de Química, Biología y Ciencias Ambientales, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.
authors.forename: Yosra
authors.initials: Y
authors.lastname: Benabdelouahab
authors.affiliation: Department of Systems Biology, Faculty of Medicine and Health Sciences, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Muñoz-Moreno
authors.affiliation: Department of Chemistry, Brooklyn College, The City University of New York, Brooklyn, New York, 11210, United States; Chemistry PhD Program, The Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Frik
authors.affiliation: Departamento de Química Orgánica y Química Inorgánica, Facultad de Química, Biología y Ciencias Ambientales, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: de la Cueva-Alique
authors.affiliation: Université Abdelmalek Essaâdi, Faculté des Sciences, Departement de Chimie- Laboratoire de Chimie Organique Appliquée. Mhannech II, B.P : 2121 Tétouan, Morocco.
authors.forename: Mohammed Amin
authors.initials: MA
authors.lastname: El Amrani
authors.affiliation: Department of Chemistry, Brooklyn College, The City University of New York, Brooklyn, New York, 11210, United States; Chemistry PhD Program, The Graduate Center, The City University of New York, 365 Fifth Avenue, New York, NY 10016, United States.
authors.forename: María
authors.initials: M
authors.lastname: Contel
authors.affiliation: Department of Systems Biology, Faculty of Medicine and Health Sciences, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Bajo
authors.affiliation: Departamento de Química Orgánica y Química Inorgánica, Facultad de Química, Biología y Ciencias Ambientales, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.
authors.forename: Tomás
authors.initials: T
authors.lastname: Cuenca
authors.affiliation: Departamento de Química Orgánica y Química Inorgánica, Facultad de Química, Biología y Ciencias Ambientales, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Royo
keywords: anticancer; arene ruthenium compounds; chiral syntheses; non-covalent interactions; oxime