title: [Genetics and genomics in rheumatoid arthritis (RA): An update].
abstract: Rheumatoid arthritis is a chronic inflammatory autoimmune disease that affects approximately 0.5-1% of the general population and leads to chronic synovial inflammation, destruction of cartilage and bone, and disability. The heritability of rheumatoid arthritis has been estimated to be about 60%, while the contribution of HLA to heritability has been estimated to be 11-37%. Other genes, such as PTPN22, STAT4, CTLA4, TRAF1, PADI4, IRF5, FCRL3, TNFIP3, TNF-α, miRNAs, CD28, CD40, TYK2, etc., have been associated with susceptibility, severity, activity, and treatment response of rheumatoid arthritis. The aim of this review is to describe the role of gene variants located in immune system genes associated with susceptibility to rheumatoid arthritis.
authors.affiliation: Posgrado en Biología Experimental, UAM-I, Hospital Juárez de México, SSA, Ciudad de México, México.|Licenciatura en Biología, Facultad de Estudios Superiores Zaragoza, UNAM, Hospital Juárez de México, SSA, Ciudad de México, México.
authors.forename: Ana Karen
authors.initials: AK
authors.lastname: Rodríguez-Elías
authors.affiliation: Licenciatura en Biología, Facultad de Estudios Superiores Zaragoza, UNAM, Hospital Juárez de México, SSA, Ciudad de México, México.|Laboratorio de Medicina Genómica, Unidad de Investigación, Hospital Juárez de México, SSA, Ciudad de México, México.
authors.forename: Karina
authors.initials: K
authors.lastname: Maldonado-Murillo
authors.affiliation: Licenciatura en Biología, Facultad de Estudios Superiores Zaragoza, UNAM, Hospital Juárez de México, SSA, Ciudad de México, México.|Laboratorio de Medicina Genómica, Unidad de Investigación, Hospital Juárez de México, SSA, Ciudad de México, México.
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: López-Mendoza
authors.affiliation: Laboratorio de Medicina Genómica, Unidad de Investigación, Hospital Juárez de México, SSA, Ciudad de México, México.
authors.forename: Julián
authors.initials: J
authors.lastname: Ramírez-Bello
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics*; D023281:Genomics; D006801:Humans