title: Hospitalization for ischemic stroke in Brazil: an ecological study on the possible impact of Hiperdia.
abstract: OBJECTIVE
  The study evaluated the trend of hospitalization for ischemic stroke (HIS) and its hospital mortality in Brazil over the last 15 years as well as the impact of the Hiperdia program in this scenario.
  
  
  METHODS
  An ecological study was designed with analytical approach and data collected in the Hospital Admission System on episodes of stroke, over the years 1998 to 2012. All data were stratified by sex and age, creating an indicator for HIS and proportion of hospital mortality. To estimate the trend of the data a polynomial curve fitting was created; and the Generalized Linear Model was applied to investigate the impact of Hiperdia on the endpoint HIS and hospital mortality. We adopted a 5% significance level to minimize an error type I.
  
  
  RESULTS
  We observed a reduction of HIS from 37.57/105 inhabitants in 1998 to 2001 to 10.33/105 inhabitants in 2002 to 2005, declining 73.64%. The reduction occurred in both sexes and for all age groups. The mortality rate of ischemic stroke also declined in Brazil since 2002, in both men and women, therefore in less than 3%; and only in the groups aged between 0 and 14 and above 80 years, we did not detect trend.
  
  
  CONCLUSIONS
  Therefore, the decline of HIS temporally coincided with the implementation of Hiperdia in 2002 and this trend continues today.
authors.affiliation: Departamento de Saúde Coletiva, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Johnnatas Mikael
authors.initials: JM
authors.lastname: Lopes
authors.affiliation: Faculdade de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Santa Cruz, RN, Brazil.
authors.forename: Gerônimo José Bouzas
authors.initials: GJ
authors.lastname: Sanchis
authors.affiliation: Faculdade de Ciências Médicas de Campina Grande, Campina Grande, PB, Brazil.
authors.forename: Jovany Luiz Alves de
authors.initials: JL
authors.lastname: Medeiros
authors.affiliation: Departamento de Fisioterapia, Universidade Estadual da Paraíba, Campina Grande, PB, Brazil.
authors.forename: Fábio Galvão
authors.initials: FG
authors.lastname: Dantas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications / Q000453:epidemiology* / Q000628:therapy*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization / Q000706:statistics & numerical data* / Q000639:trends*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy*; D013997:Time Factors; D055815:Young Adult