title: Gray Matter Characteristics in Mid and Old Aged Adults with ASD.
abstract: It is widely acknowledged that the brain anatomy of children and adolescents with autism spectrum disorder (ASD) shows a different developmental pattern then typical age-matched peers. There is however, a paucity of studies examining gray matter in mid and late adulthood in ASD. In this cross-sectional neuroimaging study, we, performed vertex-wise whole-brain and region-of-interest analyses of cortical volume, thickness, surface area, and gyrification index in 51 adults with and 49 without ASD, between 30 and 75 years. There was significant age-related volume loss and cortical thinning, but there were no group differences. The lack of significant anatomical differences between intellectual able individuals with and without ASD, suggests that ASD is not (strongly) related to gray matter morphology in mid and late adulthood.
authors.affiliation: Dutch Autism & ADHD Research Center, Brain and Cognition, University of Amsterdam, PO Box 15915, 1001 NK, Amsterdam, The Netherlands. koolschijnpcmp@gmail.com.|Amsterdam Brain and Cognition (ABC), University of Amsterdam, Amsterdam, The Netherlands. koolschijnpcmp@gmail.com.
authors.forename: P Cédric M P
authors.initials: PCMP
authors.lastname: Koolschijn
authors.affiliation: Dutch Autism & ADHD Research Center, Brain and Cognition, University of Amsterdam, PO Box 15915, 1001 NK, Amsterdam, The Netherlands.|Amsterdam Brain and Cognition (ABC), University of Amsterdam, Amsterdam, The Netherlands.|Dr. Leo Kannerhuis, Amsterdam, The Netherlands.
authors.forename: Hilde M
authors.initials: HM
authors.lastname: Geurts
mesh_terms: D000328:Adult; D000368:Aged; D000067877:Autism Spectrum Disorder / Q000000981:diagnostic imaging / Q000473:pathology*; D001921:Brain / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging / Q000379:methods*
keywords: Adults; Autism; Cortical thickness; Gray matter volume; Gyrification; Surface area