title: Subcutaneous infection by Ochroconis mirabilis in an immunocompetent patient.
abstract: Recently, the taxonomy of Ochroconis (Ascomycota, Pezizomycotina, Venturiales, Sympoventuriaceae) has been revised with the recognition of an additional genus, Verruconis. Ochroconis comprises mesophilic saprobes that occasionally infect vertebrates which mostly are cold-blooded, while Verruconis contains thermophilic species which is a neurotrope in humans and birds. On the basis of molecular data it is noted that only a single Ochroconis species regularly infects immunocompetent human hosts. Here we report a subcutaneous infection due to Ochroconis mirabilis in a 50-year-old immunocompetent female patient. In vitro antifungal susceptibility tests revealed that terbinafine was the most effective drug. The patient was successfully cured with oral administration of terbinafine 250 mg daily in combination with 3 times of topical ALA-photodynamic therapy for 9 months.
authors.affiliation: Department of Dermatology, Jining No.1 People's Hospital, Shandong, China; Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Shi
authors.affiliation: Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China.
authors.forename: Guixia
authors.initials: G
authors.lastname: Lu
authors.affiliation: Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Mei
authors.affiliation: CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.
authors.forename: G Sybren
authors.initials: GS
authors.lastname: de Hoog
authors.affiliation: KhonKaen University, KhonKaen, Thailand.
authors.forename: Kittipan
authors.initials: K
authors.lastname: Samerpitak
authors.affiliation: Shanghai Institute of Medical Mycology, Changzheng Hospital of Second Military University, Shanghai, China.
authors.forename: Shuwen
authors.initials: S
authors.lastname: Deng
authors.affiliation: Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China.
authors.forename: Yongnian
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China.
authors.forename: Weida
authors.initials: W
authors.lastname: Liu
keywords: Cutaneous infection; Ochroconis; Ochroconis musae; Terbinafine