title: Promising Health Benefits of the Strawberry: A Focus on Clinical Studies.
abstract: The potential health benefits associated with dietary intake of fruits have attracted increasing interest. Among berries, the strawberry is a rich source of several nutritive and non-nutritive bioactive compounds, which are implicated in various health-promoting and disease preventive effects. A plethora of studies have examined the benefits of strawberry consumption, such as prevention of inflammation disorders and oxidative stress, reduction of obesity related disorders and heart disease risk, and protection against various types of cancer. This review provides an overview of their nutritional and non-nutritional bioactive compounds and which factors affect their content in strawberries. In addition, the bioavailability and metabolism of major strawberry phytochemicals as well as their actions in combating many pathologies, including cancer, metabolic syndrome, cardiovascular disease, obesity, diabetes, neurodegeneration, along with microbial pathogenesis have been reviewed, with a particular attention to human studies.
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche , 60131, Ancona, Italy.
authors.forename: Sadia
authors.initials: S
authors.lastname: Afrin
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche , 60131, Ancona, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Gasparrini
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche , 60131, Ancona, Italy.|Area de Nutrición y Salud, Universidad Internacional Iberoamericana (UNINI) , Campeche, C.P. 24040, Mexico.
authors.forename: Tamara Y
authors.initials: TY
authors.lastname: Forbes-Hernandez
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche , 60131, Ancona, Italy.|Analytical and Food Chemistry Department, Faculty of Food Science and Technology, University of Vigo , E-32004 Ourense, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Reboredo-Rodriguez
authors.affiliation: Dipartimento di Scienze Agrarie, Alimentari e Ambientali, Università Politecnica delle Marche , Via Ranieri 65, 60131 Ancona, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Mezzetti
authors.affiliation: Department of Physiology, Institute of Nutrition and Food Technology ''José Mataix", Biomedical Research Centre, University of Granada , 18071 Granada, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Varela-López
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche , 60131, Ancona, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Giampieri
authors.affiliation: Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche , 60131, Ancona, Italy.|Centre for Nutrition & Health, Universidad Europea del Atlantico (UEA) , Santander 39011, Spain.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Battino
mesh_terms: D000068456:Clinical Studies as Topic; D000072001:Diet, Healthy; D031985:Fragaria / Q000737:chemistry* / Q000378:metabolism*; D005638:Fruit / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009753:Nutritive Value; D011315:Preventive Medicine
keywords: anti-inflammation; anticancer; antidiabetes; antimetabolic syndrome; antiobesity; cardioprotection; neuroprotection; phenolic compounds; strawberry