title: Correlation between the High Density Lipoprotein and its Subtypes in Coronary Heart Disease.
abstract: OBJECTIVE
  To detect the changes of high density lipoprotein (HDL) and its subtypes in serum of patients with coronary heart disease (CHD).
  
  
  METHODS
  337 hospitalized patients were selected from our hospital during August, 2014 - January, 2015, and divided into CHD group (n = 190) and control group (n = 127). Lipoprint lipoprotein analyzer was used to classify low density lipoprotein (LDL) particle size and its sub-components, as well as HDL particle size and its sub-components. The changes of the subtypes in patients with CHD were statistically analyzed. The possible mechanism was explored.
  
  
  RESULTS
  (1) Compared with the control group, the concentration of HDL in CHD patients reduced, HDLL significantly decreased (P < 0.001), while HDLS increased (P < 0.001); (2) In the patients with HDL less than 1.04 mmol/L among CHD, all HDL subtypes reduced, but HDLL had the most significant decreased; (3) HDL and all HDL subtypes were positively correlated with apolipoprotein A-I (apoA-I), of which, HDLL had the biggest correlation with apoA-I (P < 0.001); (4) HDL subtypes had good correlation with HDL, of which, HDLM had a maximum correlation with HDL (P < 0.001).
  
  
  CONCLUSIONS
  HDL maturation disorders existed in the serum of CHD patients, HDLL may be protected factor for CHD, whose decrease was closely related wit the risk increase of CHD. The cardiovascular protection function of HDLL may be related with apoA-I content.
authors.forename: Fen
authors.initials: F
authors.lastname: Gao
authors.forename: Ya-Juan
authors.initials: YJ
authors.lastname: Ren
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Shen
authors.forename: Yun-Fei
authors.initials: YF
authors.lastname: Bian
authors.forename: Chuan-Shi
authors.initials: CS
authors.lastname: Xiao
authors.forename: Hong
authors.initials: H
authors.lastname: Li
mesh_terms: D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000473:pathology*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D014280:Triglycerides / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides