title: Changes of liver enzymes and triglyceride during the menopausal transition in Japanese women.
abstract: We examined detailed changes in liver enzymes as surrogate markers for metabolic syndrome and non-alcoholic fatty liver disease (NAFLD) during the menopausal transition and the associations of liver enzymes with lipid profiles related to risk of metabolic syndrome and endocrinological hormones. We divided 393 women into seven stages by menstrual regularity, follicle-stimulating hormone level and years since menopause. Serum levels of alanine aminotranferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase, lipid parameters, glucose, and endocrinological hormones were measured. Both levels of AST and ALT increased towards early post-menopause. AST remained high in late post-menopause but ALT decreased. The AST/ALT ratio decreased towards late menopausal transition and very early post-menopause and increased thereafter. This ratio was negatively correlated with triglyceride. Significant changes in ALT and AST/ALT ratio during the menopausal transition, which were associated with triglyceride, might be involved in the occurrence of metabolic syndrome and NAFLD in Japanese women.
authors.affiliation: a Department of Obstetrics and Gynecology.
authors.forename: Sumika
authors.initials: S
authors.lastname: Matsui
authors.affiliation: b Department of Reproductive Technology , and.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yasui
authors.affiliation: a Department of Obstetrics and Gynecology.
authors.forename: Kana
authors.initials: K
authors.lastname: Kasai
authors.affiliation: a Department of Obstetrics and Gynecology.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Keyama
authors.affiliation: a Department of Obstetrics and Gynecology.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kato
authors.affiliation: c Department of Preventive Medicine , Institute of Biomedical Sciences Tokushima University Graduate School , Tokushima , Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Uemura
authors.affiliation: a Department of Obstetrics and Gynecology.
authors.forename: Akira
authors.initials: A
authors.lastname: Kuwahara
authors.affiliation: a Department of Obstetrics and Gynecology.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Matsuzaki
authors.affiliation: a Department of Obstetrics and Gynecology.
authors.forename: Minoru
authors.initials: M
authors.lastname: Irahara
mesh_terms: D000328:Adult; D000367:Age Factors; D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007564:Japan; D008055:Lipids / Q000097:blood; D008099:Liver / Q000201:enzymology*; D008593:Menopause / Q000097:blood*; D024821:Metabolic Syndrome / Q000209:etiology; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000209:etiology; D012307:Risk Factors; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D001786:Blood Glucose; D008055:Lipids; D014280:Triglycerides; D005640:Follicle Stimulating Hormone; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Liver enzymes; lipids; menopausal transition