title: Practical Management of Castleman's Disease.
abstract: Castleman's disease (CD) is a rare lymphoproliferative disorder that is most commonly present in multicentric (MCD) form in association with HIV infection. Interleukin-6 (IL-6) and human herpesvirus-8 (HHV-8) play major roles in MCD pathogenesis. Important treatment options have recently become available, particularly with the introduction of IL-6 and IL-6 receptor inhibitors for the treatment of HIV-negative patients with MCD. Though advances in therapy may improve outcomes in some patients, the prognosis remains guarded, and a stratified approach to the management of MCD is needed.
authors.affiliation: Hematology Program, St. Paul's Hospital, University of British Columbia, Vancouver, B.C., Canada.
authors.forename: Musa Fares
authors.initials: MF
authors.lastname: Alzahrani
authors.forename: Mansoor
authors.initials: M
authors.lastname: Radwi
authors.forename: Heather A
authors.initials: HA
authors.lastname: Leitch
mesh_terms: D005871:Castleman Disease; D015658:HIV Infections; D019288:Herpesvirus 8, Human; D006801:Humans; D015850:Interleukin-6; D011379:Prognosis
chemical_list: D015850:Interleukin-6