title: MicroRNA-541 promotes the proliferation of vascular smooth muscle cells by targeting IRF7.
abstract: MiRNAs play crucial roles in abnormal proliferation and invasion of VSMCs. However, the roles and mechanisms of miRNAs in VSMCs are not fully understood. In our study, we demonstrated that PDGF-BB and serum induced proliferation of VSMCs led to the upregulation of miR-541. We also showed that overexpression of miR-541 promoted VSMC proliferation and invasion. In addition, Interferon regulatory factor 7 (IRF7) was found to be a potential target of miR-541 and upregulation of IRF7 could inhibit VSMC proliferation. Restored expression of miR-541 promoted IRF7-inhibited VSMCs proliferation. In conclusion, these findings suggest that inhibitors targeting miR-541 or its specific downstream molecules may be therapeutic strategy for VSMC growth-related diseases.
authors.affiliation: Department of Cardiology, Yantaishan Hospital of Yantai Yantai 264001, Shandong, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Liaocheng People's Hospital Liaocheng 252000, Shandong, China.
authors.forename: Zonglei
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital, Central South University, Key Lab of Kidney Disease and Blood Purification in Hunan Changsha 410011, Hunan, China.
authors.forename: Shaobin
authors.initials: S
authors.lastname: Duan
authors.affiliation: Department of Nephrology, The Second Xiangya Hospital, Central South University, Key Lab of Kidney Disease and Blood Purification in Hunan Changsha 410011, Hunan, China.
authors.forename: Min
authors.initials: M
authors.lastname: Luo
keywords: IRF7; Vascular smooth muscle cells; miR-541; microRNA