title: Au/ZnO hybrid nanocatalysts impregnated in N-doped graphene for simultaneous determination of ascorbic acid, acetaminophen and dopamine.
abstract: The formation of nitrogen-doped (N-doped) graphene uses hydrothermal method with urea as reducing agent and nitrogen source. The surface elemental composition of the catalyst was analyzed through XPS, which showed a high content of a total N species (7.12at.%), indicative of the effective N-doping, present in the form of pyridinic N, pyrrolic N and graphitic N groups. Moreover, Au nanoparticles deposited on ZnO nanocrystals surface, forming Au/ZnO hybrid nanocatalysts, undergo a super-hydrophobic to super-hydrophilic conversion. Herein, we present Au/ZnO hybrid nanocatalysts impregnated in N-doped graphene sheets through sonication technique of the Au/ZnO/N-doped graphene hybrid nanostructures. The as-prepared Au/ZnO/N-doped graphene hybrid nanostructure modified glassy carbon electrode (Au/ZnO/N-doped graphene/GCE) was first employed for the simultaneous determination of ascorbic acid (AA), dopamine (DA) and acetaminophen (AC). The oxidation over-potentials of AA, DA and AC decreased dramatically, and their oxidation peak currents increased significantly at Au/ZnO/N-doped graphene/GCE compared to those obtained at the N-doped graphene/GCE and bare CCE. The peak separations between AA and DA, DA and AC, and AC and AA are large up to 195, 198 and 393mV, respectively. The calibration curves for AA, DA and AC were obtained in the range of 30.00-13.00×10(3), 2.00-0.18×10(3) and 5.00-3.10×10(3)μM, respectively. The detection limits (S/N=3) were 5.00, 0.40 and 0.80μM for AA, DA and AC, respectively.
authors.affiliation: School of Science, Honghe University, Mengzi, Yunnan 661100, PR China; Key Laboratory of Natural Pharmaceutical & Chemical Biology of Yunnan Province, Mengzi, Yunnan 661100, PR China; Fujian Key Lab of Medical Instrument & Pharmaceutical Technology, Yishan Campus, Fuzhou University, Fuzhou, Fujian 350002, PR China.
authors.forename: Xianlan
authors.initials: X
authors.lastname: Chen
authors.affiliation: School of Science, Honghe University, Mengzi, Yunnan 661100, PR China; Key Laboratory of Natural Pharmaceutical & Chemical Biology of Yunnan Province, Mengzi, Yunnan 661100, PR China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Zhang
authors.affiliation: School of Science, Honghe University, Mengzi, Yunnan 661100, PR China; Key Laboratory of Natural Pharmaceutical & Chemical Biology of Yunnan Province, Mengzi, Yunnan 661100, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Shi
authors.affiliation: School of Science, Honghe University, Mengzi, Yunnan 661100, PR China; Key Laboratory of Natural Pharmaceutical & Chemical Biology of Yunnan Province, Mengzi, Yunnan 661100, PR China.
authors.forename: Shanqing
authors.initials: S
authors.lastname: Pan
authors.affiliation: School of Science, Honghe University, Mengzi, Yunnan 661100, PR China; Key Laboratory of Natural Pharmaceutical & Chemical Biology of Yunnan Province, Mengzi, Yunnan 661100, PR China. Electronic address: liuwei4728@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Fujian Key Lab of Medical Instrument & Pharmaceutical Technology, Yishan Campus, Fuzhou University, Fuzhou, Fujian 350002, PR China.
authors.forename: Hiabo
authors.initials: H
authors.lastname: Pan
mesh_terms: D000082:Acetaminophen / Q000032:analysis*; D001205:Ascorbic Acid / Q000032:analysis*; D015374:Biosensing Techniques; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D004298:Dopamine / Q000032:analysis*; D055664:Electrochemical Techniques; D004566:Electrodes; D006046:Gold / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry; D010084:Oxidation-Reduction; D015203:Reproducibility of Results; D015034:Zinc Oxide / Q000737:chemistry
chemical_list: D000082:Acetaminophen; D002244:Carbon; D006046:Gold; D006108:Graphite; D009584:Nitrogen; D001205:Ascorbic Acid; D015034:Zinc Oxide; D004298:Dopamine
keywords: Acetaminophen; Ascorbic acid; Au/ZnO/N-doped graphene hybrid nanostructures; Dopamine; Simultaneous determination