title: neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other Applications.
abstract: To evaluate the efficacy of a suprachoroidal retinal prosthesis, a highly configurable external neurostimulator is required. In order to meet functional and safety specifications, it was necessary to develop a custom device. A system is presented which can deliver charge-balanced, constant-current biphasic pulses, with widely adjustable parameters, to arbitrary configurations of output electrodes. This system is shown to be effective in eliciting visual percepts in a patient with approximately 20 years of light perception vision only due to retinitis pigmentosa, using an electrode array implanted in the suprachoroidal space of the eye. The flexibility of the system also makes it suitable for use in a number of other emerging clinical neurostimulation applications, including epileptic seizure suppression and closed-loop deep brain stimulation. Clinical trial registration number NCT01603576 (www.clinicaltrials.gov).
authors.forename: Kyle D
authors.initials: KD
authors.lastname: Slater
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Sinclair
authors.forename: Timothy S
authors.initials: TS
authors.lastname: Nelson
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Blamey
authors.forename: Hugh J
authors.initials: HJ
authors.lastname: McDermott
keywords: Neurostimulator; bionic eye; cortical stimulation; deep brain stimulation; electrical stimulation; neural prosthesis; suprachoroidal; visual prosthesis