title: Long-term survival of donor bone marrow multipotent mesenchymal stromal cells implanted into the periosteum of patients with allogeneic graft failure.
abstract: The present study involved three patients with graft failure following allogeneic hematopoietic stem cell transplantation (allo-HSCT). We obtained multipotent mesenchymal stromal cells (MSCs) from the original hematopoietic cell donors and implanted these cells in the periosteum to treat long-term bone marrow aplasia. The results showed that in all patients endogenous blood formation was recovered 2 weeks after MSC administration. Donor MSCs were found in recipient bone marrow three and 5 months following MSC implantation. Thus, our findings indicate that functional donor MSCs can persist in patient bone marrow.
authors.affiliation: National Research Center for Hematology, Moscow, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Kuzmina
authors.affiliation: National Research Center for Hematology, Moscow, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Petinati
authors.affiliation: National Research Center for Hematology, Moscow, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Sats
authors.affiliation: National Research Center for Hematology, Moscow, Russia. ndrize@yandex.ru.|Noviy Zikovsky pr, 4, Moscow, 125167, Russia. ndrize@yandex.ru.
authors.forename: N J
authors.initials: NJ
authors.lastname: Drize
authors.affiliation: National Research Center for Hematology, Moscow, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Risinskaya
authors.affiliation: National Research Center for Hematology, Moscow, Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Sudarikov
authors.affiliation: National Research Center for Hematology, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Vasilieva
authors.affiliation: National Research Center for Hematology, Moscow, Russia.
authors.forename: M Y
authors.initials: MY
authors.lastname: Drokov
authors.affiliation: National Research Center for Hematology, Moscow, Russia.
authors.forename: E D
authors.initials: ED
authors.lastname: Michalzova
authors.affiliation: National Research Center for Hematology, Moscow, Russia.
authors.forename: E N
authors.initials: EN
authors.lastname: Parovichnikova
authors.affiliation: National Research Center for Hematology, Moscow, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Savchenko
mesh_terms: D064591:Allografts; D001855:Bone Marrow Diseases / Q000628:therapy; D002470:Cell Survival; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D010521:Periosteum / Q000166:cytology*; D014019:Tissue Donors
keywords: Allogeneic hematopoietic stem cell transplantation (allo-HSCT); Graft failure; Multipotent mesenchymal stromal cells (MSCs); Periosteal implantation