title: Complement-here, there and everywhere, but what about the transplanted organ?
abstract: The part of the innate immune system that communicates and effectively primes the adaptive immune system was termed "complement" by Ehrlich to reflect its complementarity to antibodies having previously been described as "alexine" (i.e protective component of serum) by Buchner and Bordet. It has been established that complement is not solely produced systemically but may have origin in different tissues where it can influence organ specific functions that may affect the outcome of transplanted organs. This review looks at the role of complement in particular to kidney transplantation. We look at current literature to determine whether blockade of the peripheral or central compartments of complement production may prevent ischaemic reperfusion injury or rejection in the transplanted organ. We also review new therapeutics that have been developed to inhibit components of the complement cascade with varying degrees of success leading to an increase in our understanding of the multiple triggers of this complex system. In addition, we consider whether biomarkers in this field are effective markers of disease or treatment.
authors.affiliation: MRC Centre for Transplantation, Division of Transplant Immunology and Mucosal Biology, NIHR Comprehensive Biomedical Research Centre, King's College London, Guy's & St Thomas' NHS Foundation Trust, United Kingdom.
authors.forename: R M
authors.initials: RM
authors.lastname: Montero
authors.affiliation: MRC Centre for Transplantation, Division of Transplant Immunology and Mucosal Biology, NIHR Comprehensive Biomedical Research Centre, King's College London, Guy's & St Thomas' NHS Foundation Trust, United Kingdom. Electronic address: steven.sacks@kcl.ac.uk.
authors.forename: S H
authors.initials: SH
authors.lastname: Sacks
authors.affiliation: MRC Centre for Transplantation, Division of Transplant Immunology and Mucosal Biology, NIHR Comprehensive Biomedical Research Centre, King's College London, Guy's & St Thomas' NHS Foundation Trust, United Kingdom.
authors.forename: R A
authors.initials: RA
authors.lastname: Smith
mesh_terms: D000818:Animals; D003167:Complement Activation; D051056:Complement Inactivating Agents / Q000627:therapeutic use*; D003165:Complement System Proteins / Q000378:metabolism*; D006084:Graft Rejection / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D007108:Immune Tolerance; D016030:Kidney Transplantation; D015427:Reperfusion Injury / Q000276:immunology* / Q000517:prevention & control; D014181:Transplantation Immunology
chemical_list: D051056:Complement Inactivating Agents; D003165:Complement System Proteins
keywords: Complement; Kidney transplantation; Mirococept; Therapeutics