title: Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery.
abstract: We presented the first example of Cerenkov luminescence imaging (CLI) and radioluminescence imaging (RLI) of human tumor specimens. A patient with a brain meningioma localized in the left parietal region was injected with 166 MBq of 90Y-DOTATOC the day before
  neurosurgery. The specimens of the tumor removed during surgery were imaged using both CLI and RLI using an optical imager prototype developed in our laboratory. The system is based on a cooled electron multiplied charge coupled device coupled with an f ∕0.95 17-mm C-mount lens. We showed for the first time the possibility of obtaining CLI and RLI images of fresh human brain tumor specimens removed during neurosurgery.
authors.affiliation: San Raffaele Scientific Institute, Experimental Imaging Centre, Via Olgettina N. 60, Milan 20182 Italy.
authors.forename: Antonello Enrico
authors.initials: AE
authors.lastname: Spinelli
authors.affiliation: Neurological Institute C. Besta, Neurosurgery unit 2, Via Celoria 11, Milano 20133, Italy.
authors.forename: Marco P
authors.initials: MP
authors.lastname: Schiariti
authors.affiliation: European Institute of Oncology, Nuclear Medicine Department, Via Ripamonti 435, Milan 20141, Italy.
authors.forename: Chiara M
authors.initials: CM
authors.lastname: Grana
authors.affiliation: European Institute of Oncology, Medical Physics Unit, Via Ripamonti 435, Milan 20141, Italy.
authors.forename: Mahila
authors.initials: M
authors.lastname: Ferrari
authors.affiliation: European Institute of Oncology, Medical Physics Unit, Via Ripamonti 435, Milan 20141, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Cremonesi
authors.affiliation: University of Verona, Department of Computer Science, Strada Le Grazie 15, Verona 37134, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Boschi
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D006801:Humans; D049449:Luminescence; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000601:surgery*; D009493:Neurosurgery; D061848:Optical Imaging; D015021:Yttrium Radioisotopes / Q000378:metabolism
chemical_list: D015021:Yttrium Radioisotopes; C000615496:Yttrium-90