title: Reduction in circulating level of HMGB-1 following continuous renal replacement therapy in sepsis.
abstract: Early recovery from shock improves prognosis in patients with severe sepsis and septic shock. During this period, cytokine imbalances mediate the development of organ damage and mortality. In Japan, we have access to hemoperfusion using an immobilized polymyxin B fiber column for endotoxin removal (PMX-DHP) and continuous hemodiafiltration (CHDF) as artificial support for patients with septic shock, with the aim of improving hemodynamics and organ dysfunction caused by elevated inflammatory cytokines and mediators. In this Short communication, we discuss recent findings showing anti-inflammatory treatment following these continuous renal replacement therapies in sepsis.
authors.affiliation: Division of Critical Care and Emergency Medicine, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: ueno.takuya@mgh.harvard.edu.
authors.forename: Takuya
authors.initials: T
authors.lastname: Ueno
authors.affiliation: Division of Critical Care and Emergency Medicine, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ikeda
authors.affiliation: Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Yokoyama
authors.affiliation: Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Kihara
authors.affiliation: Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Konno
authors.affiliation: Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Iwamoto
authors.affiliation: Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Tetsunosuke
authors.initials: T
authors.lastname: Shimizu
authors.affiliation: Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Martina M
authors.initials: MM
authors.lastname: McGrath
authors.affiliation: Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Anil
authors.initials: A
authors.lastname: Chandraker
mesh_terms: D005260:Female; D024243:HMGB1 Protein / Q000097:blood*; D017583:Hemodiafiltration; D006801:Humans; D008297:Male; D017582:Renal Replacement Therapy; D018805:Sepsis / Q000097:blood* / Q000628:therapy*
chemical_list: D024243:HMGB1 Protein; C585491:HMGB1 protein, human
keywords: Acute care surgery; CRRT; Cytokine; HMGB-1; Septic shock