title: Three-dimensional fiber-optic readout of single-neuron-resolved fluorescence in living brain of transgenic mice.
abstract: A bundle of individually addressable optical fibers is shown to enable three-dimensional optical readout from single neurons in live brain, as well as in intact brain extracted from transgenic mice. With individual fibers in the bundle being only a few microns in diameter, single neurons are readily resolved in brain images transmitted by the fiber bundle. The third dimension is added by scanning the fiber in the longitudinal direction, with the fluorescence return read out from only one of the fibers in the bundle.
authors.affiliation: International Laser Center, Physics Department, M.V. Lomonosov MSU, Moscow, Russia.|Kurchatov Institute National Research Center, Moscow, Russia.|Russian Quantum Center, Skolkovo, Moscow Region, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Fedotov
authors.affiliation: International Laser Center, Physics Department, M.V. Lomonosov MSU, Moscow, Russia.|Kurchatov Institute National Research Center, Moscow, Russia.
authors.forename: M S
authors.initials: MS
authors.lastname: Pochechuev
authors.affiliation: Kurchatov Institute National Research Center, Moscow, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Ivashkina
authors.affiliation: International Laser Center, Physics Department, M.V. Lomonosov MSU, Moscow, Russia.|Kurchatov Institute National Research Center, Moscow, Russia.|Russian Quantum Center, Skolkovo, Moscow Region, Russia.|Department of Physics and Astronomy, Texas A&M University, College Station TX, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Fedotov
authors.affiliation: Kurchatov Institute National Research Center, Moscow, Russia.|P.K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: K V
authors.initials: KV
authors.lastname: Anokhin
authors.affiliation: International Laser Center, Physics Department, M.V. Lomonosov MSU, Moscow, Russia.|Kurchatov Institute National Research Center, Moscow, Russia.|Russian Quantum Center, Skolkovo, Moscow Region, Russia.|Department of Physics and Astronomy, Texas A&M University, College Station TX, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Zheltikov
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology*; D005336:Fiber Optic Technology; D005453:Fluorescence; D051379:Mice; D008822:Mice, Transgenic; D009474:Neurons / Q000166:cytology*
keywords: fiber-optic neurointerfaces; neurophotonics; optogenetics