title: Small non-coding RNA biomarkers in sputum for lung cancer diagnosis.
abstract: The early detection of lung cancer can reduce the mortality. However, there is no effective means in clinical settings for noninvasively detecting lung cancer. We previously developed 3 sputum miRNA biomarkers and 2 sputum small nucleolar RNA (snoRNA) biomarkers that can potentially be used for noninvasively diagnosing lung cancer. Here we evaluate the individual and combined applications of the two types of biomarkers in different sets of lung cancer patients and controls. Combined analysis of the miRNAs and snoRNAs has a synergistic effect with 89 % sensitivity and 89 % specificity, and may provide a useful tool for lung cancer early detection.
authors.affiliation: Department of Surgery, Jiangsu Province Hospital, Nanjing University of Chinese Medicine, 155 Hanzhong Rd., Nanjing, 210029, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Su
authors.affiliation: Department of Pathology, The University of Maryland School of Medicine, 10 South Pine Street, MSTF 7th floor, Baltimore, MD, 21201-1192, USA.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Guarnera
authors.affiliation: Department of Epidemiology, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: HongBin
authors.initials: H
authors.lastname: Fang
authors.affiliation: Department of Pathology, The University of Maryland School of Medicine, 10 South Pine Street, MSTF 7th floor, Baltimore, MD, 21201-1192, USA. fjiang@som.umaryland.edu.
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor; D016022:Case-Control Studies; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D058727:RNA, Small Untranslated / Q000235:genetics*; D012372:ROC Curve; D012307:Risk Factors; D013183:Sputum
chemical_list: D014408:Biomarkers, Tumor; D058727:RNA, Small Untranslated