title: Brief Report: Immunization of HIV-Infected Adults in the UK With Haemophilus influenzae b/Meningococcal C Glycoconjugate and Pneumococcal Polysaccharide Vaccines.
abstract: U.K. guidelines for vaccinating HIV-infected adults against bacteria are based on limited data. We compared antibody responses between 211 HIV-infected and 73 HIV-uninfected adults vaccinated with pneumococcal polysaccharide vaccine (PPV) and Haemophilus influenzae b/meningococcal C polysaccharide-tetanus toxoid glycoconjugate vaccine (Hib/MenC-TT). IgG responses to Hib/MenC-TT were not significantly different. PPV induced median IgGs >1.3 μg/mL for 10/12 serotypes among HIV-uninfected participants and 5/12 in HIV-infected participants. HIV-uninfected adults had higher post-vaccination IgGs than HIV-infected adults for 4/12 serotypes (P < 0.001). Responses did not associate with CD4 count or viral suppression. In a U.K. HIV-infected population, Hib/MenC-TT induced similar responses to HIV-uninfected adults, whereas PPV induced poor responses.
authors.affiliation: *Institute of Immunity and Immunotherapy, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; †Clinical Immunology Service, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; ‡HIV Services, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom; and §Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Calman A
authors.initials: CA
authors.lastname: MacLennan
authors.forename: Alex
authors.initials: A
authors.lastname: Richter
authors.forename: James
authors.initials: J
authors.lastname: Hodson
authors.forename: Sian
authors.initials: S
authors.lastname: Faustini
authors.forename: Jane
authors.initials: J
authors.lastname: Birtwistle
authors.forename: Alison
authors.initials: A
authors.lastname: Whitelegg
authors.forename: Joyful
authors.initials: J
authors.lastname: Chigiga
authors.forename: Mebie
authors.initials: M
authors.lastname: Singo
authors.forename: Jodie
authors.initials: J
authors.lastname: Walker-Haywood
authors.forename: Betselot
authors.initials: B
authors.lastname: Mulugeta
authors.forename: Sindiso
authors.initials: S
authors.lastname: Masuka
authors.forename: Chris
authors.initials: C
authors.lastname: Mainey
authors.forename: Tim
authors.initials: T
authors.lastname: Plant
authors.forename: Mark T
authors.initials: MT
authors.lastname: Drayson
authors.forename: Kaveh
authors.initials: K
authors.lastname: Manavi
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology / Q000517:prevention & control; D000328:Adult; D000907:Antibodies, Bacterial / Q000276:immunology*; D016667:Bacterial Capsules / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007115:Immunization Schedule; D008297:Male; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines