title: Advances of Phenoxazines: Synthesis, Reactivity and Their Medicinal Applications.
abstract: Phenoxazines are an important class of heterocycles, which are emerging in the field of medicinal chemistry. They exhibit numerous biological activities, including antiviral, anticancer, anti-Alzheimer, antidiabetic, antioxidant, anti-inflammatory, antibiotic and many more. The present review focuses on the chemistry along with the medicinal applications of the phenoxazine moiety, in order to provide a greater insight for the development of future phenoxazine therapeutics.
authors.forename: Sotirios
authors.initials: S
authors.lastname: Katsamakas
authors.forename: Alexandros L
authors.initials: AL
authors.lastname: Zografos
authors.affiliation: Department of Chemistry, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54124, Greece. sarli@chem.auth.gr.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Sarli
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D001426:Bacterial Proteins / Q000378:metabolism; D009161:Mycobacterium / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy; D010078:Oxazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D013302:Streptomyces / Q000201:enzymology
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001426:Bacterial Proteins; D010078:Oxazines; C039203:phenoxazine; D010088:Oxidoreductases; C023944:2-aminophenol oxidase