title: Systems immunology: Beyond antibody titers.
abstract: Despite the evident success of currently available vaccines to prevent infectious diseases, we still lack a full understanding of the mechanisms by which vaccines induce protective immune responses. Systems immunology applies multifaceted analytical tools to better understand the immune responses to vaccines by deep characterization of the cellular components, regulatory pathways, antibody responses and immune gene profiles with the ultimate goal of identifying the complex cellular, genetic and regulatory factors and mechanisms that contribute to effective and protective immune responses.
authors.affiliation: Division of Pediatric Infectious Diseases and Center for Vaccines and Immunity, Nationwide Children's Hospital, USA; The Ohio State University, USA.
authors.forename: Raquel
authors.initials: R
authors.lastname: Cao
authors.affiliation: Division of Pediatric Infectious Diseases and Center for Vaccines and Immunity, Nationwide Children's Hospital, USA; The Ohio State University, USA.
authors.forename: Asuncion
authors.initials: A
authors.lastname: Mejias
authors.affiliation: Division of Pediatric Infectious Diseases and Center for Vaccines and Immunity, Nationwide Children's Hospital, USA; The Ohio State University, USA. Electronic address: octavio.ramilo@nationwidechildrens.org.
authors.forename: Octavio
authors.initials: O
authors.lastname: Ramilo
mesh_terms: D000917:Antibody Formation; D001424:Bacterial Infections / Q000276:immunology* / Q000517:prevention & control; D001428:Bacterial Vaccines / Q000276:immunology*; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D007159:Immunologic Tests; D049490:Systems Biology; D014765:Viral Vaccines / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology* / Q000517:prevention & control
chemical_list: D001428:Bacterial Vaccines; D014765:Viral Vaccines
keywords: Gene expression profile; Systems biology; Systems vaccinology; Transcriptomics; Vaccines