title: Solid Platelet Rich Plasma in Corneal Surgery.
abstract: Solid eye platelet-rich plasma (E-PRP) concentrates platelets in a small volume of plasma which contains a high concentration of important growth factors and cell adhesion molecules. These cell adhesion molecules and growth factors occupy a major role in wound healing and enhance the physiological procedure at the site of the injury or the surgery. There are different materials used to tectonically maintain the solid clot attached at the site where treatment is necessary. Although AM may be used for this purpose, other biomaterials such a bovine pericardium or autologous fibrin membrane are at least as effective with less interdonor variations, no biological hazards, providing a better surgical alternative than the biologically so variable amniotic membrane patch. Solid platelet-rich plasma in the form obtained in ophthalmology, E-PRP, is a reliable and effective surgical coadjuvant to promote corneal wound healing in severe corneal ulcers and corneal perforations, and may be associated with other ocular surface reconstruction procedures.
  
  
  BACKGROUND
  Supported in part by a grant from the Spanish Ministry of Science and Innovation, Centro para el Desarrollo Tecnológico Industrial (CDTI), CENIT: "Customized Eye Care", CeyeC (CEN-20091021).
authors.affiliation: Department of Cornea and Refractive Surgery, VISSUM, Madrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Arnalich
authors.affiliation: Research and Development Department, VISSUM, Alicante, Spain.
authors.forename: Alejandra E
authors.initials: AE
authors.lastname: Rodriguez
authors.affiliation: Research and Development Department, VISSUM, Alicante, Spain.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Luque-Rio
authors.affiliation: Department of Cornea and Refractive Surgery, VISSUM, Alicante, Spain. jlalio@vissum.com.|School of Medicine, Miguel Hernandez University, Alicante, Spain. jlalio@vissum.com.
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Alio
keywords: Amniotic membrane; Corneal surgery; Fibrin membrane; PRP; Platelet-rich plasma; Tutopatch