title: SATB1 is Correlated with Progression and Metastasis of Breast Cancers: A Meta-Analysis.
abstract: OBJECTIVE
  Several researches have evaluated the significance of SATB1 (Special AT-rich sequence binding protein 1) expression in breast cancers (BCs), but the results have been disputed, especially in the aspects of clinicopathological features and prognosis. Therefore, our study aimed to use a meta-analysis to summarize the clinical and prognostic relevance of SATB1 gene expression in BCs.
  
  
  METHODS
  A literature search of PubMed, EMBASE, Cochrane library, Chinese Wanfang and CNKI was performed to identify eligible studies. Ten studies total, comprising 5,185 patients (1,699 SATB1-positive and 3,486 SATB1-negative), were enrolled in our study, which was performed using Revman5.3 Software and Stata11.0 Software.
  
  
  RESULTS
  This meta-analysis showed that the expression of SATB1 was significantly higher in breast cancer than in normal tissues (OR = 12.28; 95%CI = 6.01-25.09), and was statistically related to several clinicopathological parameters, including lymph node metastasis (OR = 1.55, 95%CI = 1.01-2.39) and Tumor Node Metastasis(TNM) stage (OR = 0.35, 95%CI = 0.22-0.56). However, the level of SATB1 was not statistically associated with the age (OR = 1.13, 95%CI = 0.87-1.46), tumour size (OR = 0.72, 95%CI = 0.44-1.19), estrogen receptor (OR = 0.78, 95%CI = 0.55-1.09), progesterone receptor (OR = 0.64, 95%CI = 0.32-1.29), HER2 status (OR=1.98, 95%CI = 0.74-5.30), and histological type (OR = 0.49, 95%CI = 0.22-1.11).
  
  
  CONCLUSIONS
  High expression of SATB1 was significantly correlated with tumourigenesis and metastasis of BCs, indicating poor prognosis for patients. SATB1 could serve as a potential marker for detection and prognosis evaluation of breast cancers.
authors.forename: Zhongya
authors.initials: Z
authors.lastname: Pan
authors.forename: Wei
authors.initials: W
authors.lastname: Jing
authors.forename: Keli
authors.initials: K
authors.lastname: He
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Xinghua
authors.initials: X
authors.lastname: Long
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D016208:Databases, Factual; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D006801:Humans; D008207:Lymphatic Metastasis; D036961:Matrix Attachment Region Binding Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D016017:Odds Ratio; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D036961:Matrix Attachment Region Binding Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C076189:SATB1 protein, human; C508053:ERBB2 protein, human