title: Infectiousness of HIV-Seropositive Patients with Tuberculosis in a High-Burden African Setting.
abstract: Policy recommendations on contact investigation of HIV-seropositive patients with tuberculosis have changed several times. Current epidemiologic evidence informing these recommendations is considered low quality, and few large studies investigating the infectiousness of HIV-seropositive and -seronegative index cases have been performed in sub-Saharan Africa.
  
  
  
  We assessed the infectiousness of HIV-seropositive and -seronegative patients with tuberculosis to their household contacts and examined potential modifiers of this relationship.
  
  
  
  Adults suffering from their first episode of pulmonary tuberculosis were identified in Kampala, Uganda. Field workers visited index households and enrolled consenting household contacts. Latent tuberculosis infection was measured through tuberculin skin testing, and relative risks were calculated using modified Poisson regression models. Standard assessments of interaction between latent tuberculosis infection, the HIV serostatus of index cases, and other variables were performed.
  
  
  
  Latent tuberculosis infection was found in 577 of 878 (65.7%) and 717 of 974 (73.6%) household contacts of HIV-seropositive and -seronegative tuberculosis cases (relative risk, 0.89; 95% confidence interval, 0.82-0.97). On further stratification, cavitary lung disease (P < 0.0001 for interaction) and smear status (P = 0.02 for interaction) of tuberculosis cases modified the infectiousness of HIV-seropositive indexes. Cough duration of index cases did not display interaction (P = 0.499 for interaction).
  
  
  
  This study suggests that HIV-seropositive tuberculosis cases may be less infectious than HIV-seronegative patients only when they are smear-negative or lack cavitary lung disease. These results may explain heterogeneity between prior studies and provide evidence suggesting that tuberculosis contact investigation should include HIV-seropositive index cases in high disease burden settings.
authors.affiliation: 1 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia.
authors.forename: Leonardo
authors.identifier: 0000-0003-0954-8489
authors.initials: L
authors.lastname: Martinez
authors.affiliation: 1 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia.|2 School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda; and.
authors.forename: Juliet N
authors.initials: JN
authors.lastname: Sekandi
authors.affiliation: 1 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia.
authors.forename: María E
authors.initials: ME
authors.lastname: Castellanos
authors.affiliation: 3 Uganda-CWRU Research Collaboration, Makerere University and Mulago Hospital, Kampala, Uganda.
authors.forename: Sarah
authors.initials: S
authors.lastname: Zalwango
authors.affiliation: 1 Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Whalen
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005191:Family Characteristics; D005260:Female; D006679:HIV Seropositivity / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D055985:Latent Tuberculosis / Q000453:epidemiology / Q000635:transmission; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000635:transmission*; D014454:Uganda / Q000453:epidemiology; D055815:Young Adult
keywords: HIV; Mycobacterium tuberculosis; household contacts; infectiousness; tuberculosis infection