title: Current Approaches of Photothermal Therapy in Treating Cancer Metastasis with Nanotherapeutics.
abstract: Cancer metastasis accounts for the high mortality of many types of cancer. Owing to the unique advantages of high specificity and minimal invasiveness, photothermal therapy (PTT) has been evidenced with great potential in treating cancer metastasis. In this review, we outline the current approaches of PTT with respect to its application in treating metastatic cancer. PTT can be used alone, guided with multimodal imaging, or combined with the current available therapies for effective treatment of cancer metastasis. Numerous types of photothermal nanotherapeutics (PTN) have been developed with encouraging therapeutic efficacy on metastatic cancer in many preclinical animal experiments. We summarize the design and performance of various PTN in PTT alone and their combinational therapy. We also point out the lacking area and the most promising approaches in this challenging field. In conclusion, PTT or their combinational therapy can provide an essential promising therapeutic modality against cancer metastasis.
authors.affiliation: 1. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China;
authors.forename: Lili
authors.initials: L
authors.lastname: Zou
authors.affiliation: 2. State key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: 2. State key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
authors.forename: Bin
authors.initials: B
authors.lastname: He
authors.affiliation: 3. School of Pharmacy, Shenyang Pharmaceutics University, Shenyang, 110016, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zeng
authors.affiliation: 3. School of Pharmacy, Shenyang Pharmaceutics University, Shenyang, 110016, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Tan
authors.affiliation: 2. State key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
authors.forename: Haiqiang
authors.initials: H
authors.lastname: Cao
authors.affiliation: 2. State key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
authors.forename: Xinyu
authors.initials: X
authors.lastname: He
authors.affiliation: 2. State key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: 1. School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China;
authors.forename: Shengrong
authors.initials: S
authors.lastname: Guo
authors.affiliation: 2. State key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
authors.forename: Yaping
authors.initials: Y
authors.lastname: Li
mesh_terms: D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D050997:Nanomedicine / Q000379:methods*; D049329:Nanostructures / Q000008:administration & dosage*; D009362:Neoplasm Metastasis / Q000628:therapy*; D009369:Neoplasms / Q000628:therapy*; D010789:Phototherapy / Q000379:methods*
keywords: Cancer metastasis; Drug delivery.; Nanotherapeutics; Photothermal therapy