title: Influence of coumarin and some coumarin derivatives on serum lipid profiles in carbontetrachloride-exposed rats.
abstract: In the present study, coumarin and some coumarin derivatives (esculetin, scoparone, and 4-methylumbelliferone) were investigated for their lipid-lowering effect in rats. Male Sprague-Dawley rats (150-200 g) were divided into six groups and each group comprised of five rats. Hepatic injury-dependent hyperlipidemia was induced by carbon tetrachloride (CCl4, 1.25 ml/kg). Coumarin and coumarin derivatives esculetin (35 mg/kg), scoparone (35 mg/kg), 4-methylumbelliferone (35 mg/kg), or coumarin (30 mg/kg) were administered to experimental groups at 12-h intervals. Animals received the derivatives esculetin, scoparone or 4-methylumbelliferone prior to the administration of a single toxic dose of CCl4.Serum total cholesterol (TC), triglyceride (TG), very low-density lipoprotein cholesterol (VLDL-C), and low-density lipoprotein cholesterol (LDL-C) levels significantly increased in CCl4-treated group ( p < 0.05, p < 0.01, p < 0.01, and p < 0.05, respectively), while levels of serum high-density lipoprotein cholesterol (HDL-C) decreased ( p < 0.01). 4-Methylumbelliferone had no recovery effects on serum TC levels, however, significantly prevented CCl4-induced hyperlipidemia by reducing TG and VLDL-C levels ( p < 0.05 and p < 0.05, respectively). In addition, coumarin had no recovery effect on any of the serum lipid parameters against CCl4-induced hyperlipidemia. Among the coumarin derivatives only esculetin and scoparone significantly prevented serum HDL-C in CCl4-induced dyslipidemia. The results from this study indicate that the chemical structure of coumarins plays an important role on the regulation of serum lipid profiles.
authors.affiliation: 1 Department of Internal Medicine, Medical Park Hospital, Antalya, Turkey.
authors.forename: Ezel
authors.initials: E
authors.lastname: Taşdemir
authors.affiliation: 2 Department of Physiology, Dicle University, Diyarbakır, Turkey.
authors.forename: Mukadder
authors.initials: M
authors.lastname: Atmaca
authors.affiliation: 3 Department of Internal Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Yıldırım
authors.affiliation: 2 Department of Physiology, Dicle University, Diyarbakır, Turkey.
authors.forename: Hakkı Murat
authors.initials: HM
authors.lastname: Bilgin
authors.affiliation: 4 Vocational School of Veterinary Medicine, Istanbul University, İstanbul, Turkey.
authors.forename: Berjan
authors.initials: B
authors.lastname: Demirtaş
authors.affiliation: 2 Department of Physiology, Dicle University, Diyarbakır, Turkey.
authors.forename: Basra Deniz
authors.initials: BD
authors.lastname: Obay
authors.affiliation: 2 Department of Physiology, Dicle University, Diyarbakır, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kelle
authors.affiliation: 2 Department of Physiology, Dicle University, Diyarbakır, Turkey.
authors.forename: Hüda Diken
authors.initials: HD
authors.lastname: Oflazoğlu
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D003374:Coumarins / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003374:Coumarins; D008055:Lipids; D002251:Carbon Tetrachloride
keywords: CCl4; Coumarins; lipid; rat