title: Self-cleaning and antibiofouling enamel surface by slippery liquid-infused technique.
abstract: We aimed to create a slippery liquid-infused enamel surface with antibiofouling property to prevent dental biofilm/plaque formation. First, a micro/nanoporous enamel surface was obtained by 37% phosphoric acid etching. The surface was then functionalized by hydrophobic low-surface energy heptadecafluoro-1,1,2,2-tetra- hydrodecyltrichlorosilane. Subsequent infusion of fluorocarbon lubricants (Fluorinert FC-70) into the polyfluoroalkyl-silanized rough surface resulted in an enamel surface with slippery liquid-infused porous surface (SLIPS). The results of water contact angle measurement, diffuse-reflectance Fourier transform infrared spectroscopy, and atomic force microscope confirmed that the SLIPS was successfully constructed on the enamel surface. The antibiofouling property of the SLIPS was evaluated by the adsorption of salivary protein of mucin and Streptococcus mutans in vitro, as well as dental biofilm formation using a rabbit model in vivo. The results showed that the SLIPS on the enamel surface significantly inhibited mucin adhesion and S. mutans biofilm formation in vitro, and inhibited dental plaque formation in vivo.
authors.affiliation: College &Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, 230032, China.
authors.forename: JiaLi
authors.initials: J
authors.lastname: Yin
authors.affiliation: Faculty of Dentistry, University of Hong Kong, Hong Kong, 999077.
authors.forename: May Lei
authors.initials: ML
authors.lastname: Mei
authors.affiliation: College &Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, 230032, China.
authors.forename: QuanLi
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Stomatology, the Second Hospital affiliated to Anhui Medical University, Hefei, 230601, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Xia
authors.affiliation: Department of Stomatology, the Hospital of Anhui Province, Hefei, 230001, China.
authors.forename: ZhiHong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Faculty of Dentistry, University of Hong Kong, Hong Kong, 999077.
authors.forename: Chun Hung
authors.initials: CH
authors.lastname: Chu