title: IGF-1 and IGFBP-1 in peripheral blood and decidua of early miscarriages with euploid embryos: comparison between women with and without PCOS.
abstract: This study aims to demonstrate the possible relationship between the insulin-like growth factor (IGF) system and early miscarriage in polycystic ovarian syndrome (PCOS) patients with euploid embryos. 40 pregnant women included. 9 had PCOS and miscarried; 20 had PCOS and a successful ongoing pregnancy; the remaining 11 women did not have PCOS and miscarried. An ultrasound scan was performed to prove clinical pregnancy and a blood sample was taken on day 55 ± 4 of gestation. Serum samples of IGF-1, insulin-like growth factor binding protein-1 (IGFBP-1), total testosterone, serum hormone binding protein (SHBG), leptin and soluble leptin receptor (sOb-R) were obtained. In miscarriages, samples of decidua were obtained during vaccum curettage. Embryonic chromosomes in all miscarriages were proven to be normal. The expression of IGF-1, IGFBP-1, leptin, long-form leptin receptor and androge sOb-R n receptor (AR) were examined in the decidua. We found that miscarried PCOS patients showed significantly increased free androgen index and free IGF index, as well as decreased SHBG and IGFBP-1 than other two groups in peripheral blood. In the decidua, miscarried PCOS patients showed significantly increased expression of IGF-1 and decreased IGFBP-1 when compared with non-PCOS. AR was not expressed in the decidua of either group. Our results suggest that early miscarriage is associated with increased IGF-1 and decreased IGFBP-1 in PCOS patients.
authors.affiliation: a Reproductive Medicine Center and Guangdong Provincial Key Laboratory of Reproductive Medicine, The First Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong , P.R. China and.
authors.forename: Lu
authors.initials: L
authors.lastname: Luo
authors.affiliation: a Reproductive Medicine Center and Guangdong Provincial Key Laboratory of Reproductive Medicine, The First Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong , P.R. China and.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: a Reproductive Medicine Center and Guangdong Provincial Key Laboratory of Reproductive Medicine, The First Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong , P.R. China and.
authors.forename: Minghui
authors.initials: M
authors.lastname: Chen
authors.affiliation: b Teaching and Researching Section of Molecular Medicine, Zhongshan School of Medicine, Sun Yat-Sen University , Guangzhou, Guangdong , P.R. China.
authors.forename: Guangqing
authors.initials: G
authors.lastname: Yuan
authors.affiliation: a Reproductive Medicine Center and Guangdong Provincial Key Laboratory of Reproductive Medicine, The First Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong , P.R. China and.
authors.forename: Zengyan
authors.initials: Z
authors.lastname: Wang
authors.affiliation: a Reproductive Medicine Center and Guangdong Provincial Key Laboratory of Reproductive Medicine, The First Affiliated Hospital of Sun Yat-Sen University , Guangzhou, Guangdong , P.R. China and.
authors.forename: Canquan
authors.initials: C
authors.lastname: Zhou
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood / Q000378:metabolism*; D000328:Adult; D003656:Decidua / Q000378:metabolism*; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy
chemical_list: C583557:IGF1 protein, human; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D007334:Insulin-Like Growth Factor I
keywords: Early miscarriage; IGF-1; IGFBP-1; polycystic ovary syndrome