title: NIR light/H2O2-triggered nanocomposites for a highly efficient and selective synergistic photodynamic and photothermal therapy against hypoxic tumor cells.
abstract: In this work, smart near-infrared (NIR) light/H2O2-triggered and O2-evolving nanocomposites were designed and applied for efficient production of (1)O2 by converting a deeply penetrating NIR light into a visible light to excite the photosensitizers and achieve a self-sufficiency of the O2 generation in the photodynamic therapy process to overcome the hypoxia-induced drug resistance.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. tangyu@lzu.edu.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Shen
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Kirillov
authors.forename: Wei-Sheng
authors.initials: WS
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Tang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry*; D000860:Hypoxia / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D007259:Infrared Rays; D008297:Male; D053761:Nanocomposites / Q000737:chemistry*; D055668:Photochemical Processes; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010789:Phototherapy; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D013329:Structure-Activity Relationship
chemical_list: D017319:Photosensitizing Agents; D006861:Hydrogen Peroxide