title: Sponsored multicentric clinical research conducted in Brazil in the respiratory area - losses and gains.
abstract: OBJECTIVE
  To evaluate the sponsored centers for clinical trial in the respiratory care setting in Brazil: profile; logistics and structure.
  
  
  METHODS
  Principal investigators (29) and subinvestigators (30) of 39 research centers completed the questionnaires that addressed personal identification and training of researchers, the centers' facilities and advantages and/or disadvantages of performing sponsored trials.
  
  
  RESULTS
  75.6% of the centers were located in southern and southeastern Brazil. Most principal investigators were men with a mean age of 53.4 years. The clinical trials in the respiratory care setting focus on asthma and chronic obstructive pulmonar disease (COPD). 80% of the researchers cited delay of the Conep and Anvisa as a barrier to performing research. The advantages of participating in clinical trials were updating knowledge of the researcher and the team, and additional income for the team. The main disadvantages mentioned by the researchers included low financial compensation for the performed workload, and time availability. The median number of professionals per research center was six people, predominantly physicians.
  
  
  CONCLUSIONS
  The number of research centers in the respiratory care setting in Brazil is still relatively small. The teams have good training for performing the clinical trials. Asthma and COPD are the most studied diseases in sponsored clinical trials. The main barrier is delay by the Conep and Anvisa. The factors that lead investigators to participate range from being updated along with the team, to site and staff financial issues; the main disadvantage is the low compensation for the required workload demand.
authors.affiliation: Graduate Program in Cardiorespiratory Physiotherapy, Universidade de Fortaleza, Fortaleza, CE, Brazil.
authors.forename: Andréa Kelly da Silveira
authors.initials: AK
authors.lastname: Carvalho
authors.affiliation: Pulmonology Department, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Oliver Augusto
authors.initials: OA
authors.lastname: Nascimento
authors.affiliation: Unifesp, São Paulo, SP, Brazil.
authors.forename: Marcelo Cunio Machado
authors.initials: MC
authors.lastname: Fonseca
authors.affiliation: Internal Medicine Department, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
authors.forename: Eanes Delgado Barros
authors.initials: ED
authors.lastname: Pereira
authors.affiliation: Escola Paulista de Medicina, Unifesp, São Paulo, SP, Brazil.
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Jardim
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma; D035843:Biomedical Research / Q000706:statistics & numerical data*; D001938:Brazil; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic / Q000706:statistics & numerical data*; D029424:Pulmonary Disease, Chronic Obstructive; D012108:Research Personnel / Q000706:statistics & numerical data*; D012109:Research Support as Topic / Q000706:statistics & numerical data*; D012124:Respiratory Care Units / Q000706:statistics & numerical data; D011795:Surveys and Questionnaires; D055815:Young Adult