title: Left Ventricular Strain and Rotation by 2-D Speckle Tracking Echocardiography Identify Early Alcoholic Cardiomyopathy.
abstract: This study assessed whether 2-D speckle tracking echocardiography (STE) derived from left ventricular (LV) strain and rotation is capable of detecting LV dysfunction associated with alcoholic cardiomyopathy. Ninety-two male chronic alcoholic patients were grouped by alcohol intake amount and duration: mild (n = 30; >90 mg ethanol daily, 3-5 d per wk for 5-8 y); moderate (n = 30; >90-150 mg ethanol daily, 3-5 d per wk for 9-20 y); and severe (n = 32; >150 mg ethanol daily, 6-7 d per wk for >10 y). Thirty non-drinkers were recruited as healthy controls. Rotation and twist values were lower in the severe group compared with the other groups (p < 0.05). The moderate and severe alcohol groups demonstrated lower longitudinal, circumferential and radial strain values and early to late filling (E/A) ratios compared with the mild group and non-drinkers (all p < 0.05). 2-D STE-derived strain and rotation are reliable echocardiographic markers for detecting left ventricular dysfunction in patients at risk of developing alcoholic cardiomyopathy.
authors.affiliation: Department of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Yuanzheng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. Electronic address: liguangsen09@163.com.
authors.forename: Guangsen
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Functional, The First People's Hospital of Khorchin, Tongliao, Inner Mongolia, China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Guoxin
authors.initials: G
authors.lastname: Shan
authors.affiliation: Department of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Xu
authors.affiliation: Department of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D002310:Cardiomyopathy, Alcoholic / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D042241:Early Diagnosis; D004452:Echocardiography / Q000379:methods*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology*
keywords: 2-D speckle tracking echocardiography; Alcoholic cardiomyopathy; Alcoholics; Left ventricular function