title: Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in pigs.
abstract: Porcine periweaning-failure-to-thrive syndrome (PFTS) is a condition that affects newly weaned piglets. It is characterised by a progressive debilitation leading to death, in the absence of infectious, nutritional, management or environmental factors. In this study, we present the first report of PFTS in South America and the results of a genome-wide association study to identify the genetic markers associated with the appearance of this condition in a crossbred swine population. Four chromosomal regions were associated with PFTS predisposition, one located on SSCX, one on SSC8, and the two other regions on SSC14. Regions on SSC8 and SSC14 harbour important functional candidate genes involved in human depression and might have an important role in PFTS. Our findings contribute to the increasing knowledge about this syndrome, which has been investigated since 2007, and to the identification of the aetiology of this disease.
authors.affiliation: Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil.
authors.forename: R
authors.identifier: http://orcid.org/0000-0003-1449-6708
authors.initials: R
authors.lastname: Zanella
authors.affiliation: Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil.
authors.forename: N
authors.initials: N
authors.lastname: Morés
authors.affiliation: Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil.
authors.forename: M A Z
authors.initials: MA
authors.lastname: Morés
authors.affiliation: Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil.
authors.forename: J O
authors.initials: JO
authors.lastname: Peixoto
authors.affiliation: R. Zanella's present address is College of Veterinary Medicine, University of Passo Fundo, Passo Fundo, RS, Brazil.
authors.forename: E L
authors.initials: EL
authors.lastname: Zanella
authors.affiliation: Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil.
authors.forename: J R
authors.identifier: http://orcid.org/0000-0002-6259-6028
authors.initials: JR
authors.lastname: Ciacci-Zanella
authors.affiliation: Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil.
authors.forename: A M G
authors.identifier: http://orcid.org/0000-0003-0626-8879
authors.initials: AM
authors.lastname: Ibelli
authors.affiliation: Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil.
authors.forename: D
authors.identifier: http://orcid.org/0000-0002-1917-2633
authors.initials: D
authors.lastname: Gava
authors.affiliation: Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil.
authors.forename: M E
authors.initials: ME
authors.lastname: Cantão
authors.affiliation: Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil.
authors.forename: M C
authors.initials: MC
authors.lastname: Ledur
mesh_terms: D000818:Animals; D005183:Failure to Thrive / Q000235:genetics / Q000662:veterinary*; D005260:Female; D055106:Genome-Wide Association Study; D008297:Male; D013552:Swine; D013553:Swine Diseases / Q000235:genetics*; D014886:Weaning
keywords: Depression; GWAS; SNP; Sus scrofa