title: In-situ reduction of monodisperse nanosilver on hierarchical wrinkled mesoporous silica with radial pore channels and its antibacterial performance.
abstract: Monodisperse silver nanoparticles (Ag NPs) were facilely loaded on the inner and outer surface of hierarchical wrinkled mesoporous silica (WMSs) via an in situ chemical reduction, and the antibacterial capacity of the obtained nanocomposite was investigated in detail. Typical sulfydryl-functionalized wrinkled mesoporous silica nanoparticle with radical pore channels was firstly prepared through sol-gel technique with cetyltrimethylammonium bromide (CTAB) as the templating surfactant. After sulfonation of the as-prepared WMSs, Ag(+) ions were then densely locked up on the inner and outer surface of WMSs via electrostatic interactions. Well distributed Ag NPs (ca. 3-5nm) on WMSs without any agglomeration were finally obtained via a simple in situ reduction reaction with sodium borohydride. Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) test indicated that the obtained products can achieve durable and much better antibacterial performance both against Gram-negative bacterium Escherichia coli (E. coli) and Gram-positive bacterium Staphylococcus aureus (S. aureus) comparing to pure colloidal silver nanoparticles, which rendered them as favorable candidate for the development of effective antibacterial agents.
authors.affiliation: Shenzhen Key Laboratory of Polymer Science and Technology, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China; Guangdong Research Center for Interfacial Engineering of Functional Materials, Shenzhen 518060, China. Electronic address: wanxj@szu.edu.cn.
authors.forename: Xuejuan
authors.initials: X
authors.lastname: Wan
authors.affiliation: Shenzhen Key Laboratory of Polymer Science and Technology, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Zhuang
authors.affiliation: Shenzhen Key Laboratory of Polymer Science and Technology, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
authors.forename: Boxi
authors.initials: B
authors.lastname: She
authors.affiliation: Shenzhen Key Laboratory of Polymer Science and Technology, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
authors.forename: Yuanming
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Shenzhen Key Laboratory of Polymer Science and Technology, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
authors.forename: Dazhu
authors.initials: D
authors.lastname: Chen
authors.affiliation: Shenzhen Key Laboratory of Polymer Science and Technology, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China; Guangdong Research Center for Interfacial Engineering of Functional Materials, Shenzhen 518060, China. Electronic address: tjn@szu.edu.cn.
authors.forename: Jiaoning
authors.initials: J
authors.lastname: Tang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D010084:Oxidation-Reduction; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002593:Cetrimonium Compounds; D012834:Silver; D012822:Silicon Dioxide; D000077286:Cetrimonium
keywords: Ag nanoparticles; Antibacterial property; Hierarchical; Mesoporous silica; Wrinkle structure