title: Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats.
abstract: Angiotensin converting enzyme inhibitors and propofol both exert hypotensive action and may affect hemostasis. We investigated the influence of quinapril and propofol on hemodynamics and hemostasis in renal-hypertensive rats with induced arterial thrombosis. Two-kidney, one clip hypertensive rats were treated with quinapril (3.0 mg/kg for 10 days), and then received propofol infusion (15 mg/kg/h) during ongoing arterial thrombosis. The hemodynamic and hemostatic parameters were assayed. Quinapril exerted a hypotensive effect increasing after propofol infusion. Quinapril showed an antithrombotic effect with the platelet adhesion reduction, fibrinolysis enhancement and oxidative stress reduction. Propofol did not influence thrombosis; however, it inhibited fibrinolysis and showed prooxidative action. The effect of propofol on fibrinolysis and oxidative stress was significantly lower in quinapril-pretreated rats. Mortality was increased among rats treated with both drugs together. Our study demonstrates that pretreatment with quinapril reduced the adverse effects of propofol on hemostasis. Unfortunately, co-administration of both drugs potentiated hypotension in rats, which corresponds to higher mortality.
authors.affiliation: Department of Emergency and Disaster Medicine, Medical University of Bialystok, Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Wojewodzka-Zelezniakowicz
authors.affiliation: Department of Biopharmacy, Medical University of Bialystok, Poland.
authors.forename: Wioleta
authors.initials: W
authors.lastname: Kisiel
authors.affiliation: Department of Biopharmacy, Medical University of Bialystok, Poland.
authors.forename: Karol
authors.initials: K
authors.lastname: Kramkowski
authors.affiliation: Department of Biopharmacy, Medical University of Bialystok, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Gromotowicz-Poplawska
authors.affiliation: Department of Biopharmacy, Medical University of Bialystok, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Zakrzeska
authors.affiliation: Department of Biopharmacy, Medical University of Bialystok, Poland.
authors.forename: Adrian
authors.initials: A
authors.lastname: Stankiewicz
authors.affiliation: Department of Biopharmacy, Medical University of Bialystok, Poland.
authors.forename: Patrycjusz
authors.initials: P
authors.lastname: Kolodziejczyk
authors.affiliation: Department of Medical Biochemistry, Medical University of Lodz, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Szemraj
authors.affiliation: Department of Emergency and Disaster Medicine, Medical University of Bialystok, Poland.
authors.forename: Jerzy Robert
authors.initials: JR
authors.lastname: Ladny
authors.affiliation: Department of Biopharmacy, Medical University of Bialystok, Poland chabewa@poczta.onet.pl.
authors.forename: Ewa
authors.initials: E
authors.lastname: Chabielska
mesh_terms: D000818:Animals; D000933:Antifibrinolytic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001011:Aorta / Q000187:drug effects / Q000201:enzymology / Q000503:physiopathology; D002339:Carotid Arteries / Q000187:drug effects / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D019255:NADPH Oxidases / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D016877:Oxidants / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D010973:Platelet Adhesiveness / Q000187:drug effects; D015742:Propofol / Q000494:pharmacology / Q000627:therapeutic use*; D000077583:Quinapril; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism; D016019:Survival Analysis; D044005:Tetrahydroisoquinolines / Q000494:pharmacology / Q000627:therapeutic use*; D013927:Thrombosis / Q000097:blood / Q000150:complications / Q000188:drug therapy*
chemical_list: D000933:Antifibrinolytic Agents; D016877:Oxidants; D044005:Tetrahydroisoquinolines; D009569:Nitric Oxide; D013482:Superoxide Dismutase; D019255:NADPH Oxidases; D000077583:Quinapril; D015742:Propofol
keywords: Quinapril; hypertension; propofol; rat; thrombosis