title: Endothelial Barrier and Metabolism: New Kids on the Block Regulating Bone Marrow Vascular Niches.
abstract: The vasculature of the bone marrow remains poorly characterized, yet crucial to maintain hematopoiesis and retain stem cells in a quiescent state. A recent study by Itkin et al. (2016) in Nature reports how vascular barrier integrity and endothelial cell metabolism regulate hematopoietic stem cell quiescence and leukocyte trafficking.
authors.affiliation: Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, Department of Oncology, University of Leuven, 3000 Leuven, Belgium.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Harjes
authors.affiliation: Stem Cell Biology and Embryology Unit, Department of Development and Regeneration, University of Leuven, 3000 Leuven, Belgium.
authors.forename: Catherine
authors.initials: C
authors.lastname: Verfaillie
authors.affiliation: Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, Department of Oncology, University of Leuven, 3000 Leuven, Belgium. Electronic address: peter.carmeliet@vib-kuleuven.be.
authors.forename: Peter
authors.initials: P
authors.lastname: Carmeliet
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism*; D002199:Capillary Permeability; D042783:Endothelial Cells / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D055153:Stem Cell Niche