title: Remodeling of Calcium Entry Pathways in Cancer.
abstract: Ca(2+) entry pathways play important roles in control of many cellular functions, including long-term proliferation, migration and cell death. In recent years, it is becoming increasingly clear that, in some types of tumors, remodeling of Ca(2+) entry pathways could contribute to cancer hallmarks such as excessive proliferation, cell migration and invasion as well as resistance to cell death or survival. In this chapter we briefly review findings related to remodeling of Ca(2+) entry pathways in cancer with emphasis on the mechanisms that contribute to increased store-operated Ca(2+) entry (SOCE) and store-operated currents (SOCs) in colorectal cancer cells. Finally, since SOCE appears critically involved in colon tumorogenesis, the inhibition of SOCE by aspirin and other NSAIDs and its possible contribution to colon cancer chemoprevention is reviewed.
authors.affiliation: Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Científicas (CSIC), C/Sanz y Forés 3, 47003, Valladolid, Spain. carlosv@ibgm.uva.es.
authors.forename: Carlos
authors.initials: C
authors.lastname: Villalobos
authors.affiliation: Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Científicas (CSIC), C/Sanz y Forés 3, 47003, Valladolid, Spain.
authors.forename: Diego
authors.initials: D
authors.lastname: Sobradillo
authors.affiliation: Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Científicas (CSIC), C/Sanz y Forés 3, 47003, Valladolid, Spain.
authors.forename: Miriam
authors.initials: M
authors.lastname: Hernández-Morales
authors.affiliation: Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Científicas (CSIC), C/Sanz y Forés 3, 47003, Valladolid, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Núñez
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D017136:Ion Transport; D009369:Neoplasms / Q000378:metabolism* / Q000517:prevention & control
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin; D002118:Calcium
keywords: Aspirin; Cancer; Colorectal cancer; NSAID; Store-operated Ca2+ entry