title: Characterization of Intracranial Pressure Behavior in Chronic Epileptic Animals: A Preliminary Study.
abstract: Intracranial pressure (ICP) is a major neurological parameter in animals and humans. ICP is a function of the relationship between the contents of the cranium (brain parenchyma, cerebrospinal fluid, and blood) and the volume of the skull. Increased ICP can cause serious physiological effects or even death in patients who do not quickly receive proper care, which includes ICP monitoring. Epilepsies are a set of central nervous system disorders resulting from abnormal and excessive neuronal discharges, usually associated with hypersynchronism and/or hyperexcitability. Temporal lobe epilepsy (TLE) is one of the most common forms of epilepsy and is also refractory to medication. ICP characteristics of subjects with epilepsy have not been elucidated because there are few studies associating these two important neurological factors. In this work, an invasive (ICPi) and the new minimally invasive (ICPmi) methods were used to evaluate ICP features in rats with chronic epilepsy, induced by the experimental model of pilocarpine, capable of generating the main features of human TLE in these animals.
authors.affiliation: Federal University of Sao Carlos, Joint Graduate Program in Physiological Sciences, PIPGCF. Rodovia Washington Luis, km 235, SP-310. CEP 13565-905., Sao Carlos, Sao Paulo, Brazil. danilo.cardim@gmail.com.
authors.forename: Danilo Augusto
authors.initials: DA
authors.lastname: Cardim
authors.affiliation: Baincare Corp., Sapra, Sao Carlos, Brazil.
authors.forename: Gustavo Henrique
authors.initials: GH
authors.lastname: Frigieri
authors.affiliation: Baincare Corp., Sapra, Sao Carlos, Brazil.
authors.forename: Brenno Caetano Troca
authors.initials: BC
authors.lastname: Cabella
authors.affiliation: Department of Physiology, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Jackeline Moraes
authors.initials: JM
authors.lastname: Malheiros
authors.affiliation: Physics Institute of Sao Carlos, University of Sao Paulo, Sao Carlos, Brazil.
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Cardim
authors.affiliation: Baincare Corp., Sapra, Sao Carlos, Brazil.
authors.forename: Charles Chenwei
authors.initials: CC
authors.lastname: Wang
authors.affiliation: Baincare Corp., Sapra, Sao Carlos, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: de Albuquerque Pacheco Andrade
authors.affiliation: Department of Physiology, Federal University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Luciene
authors.initials: L
authors.lastname: Covolan
authors.affiliation: Physics Institute of Sao Carlos, University of Sao Paulo, Sao Carlos, Brazil.
authors.forename: Alberto
authors.initials: A
authors.lastname: Tannús
authors.affiliation: Physics Institute of Sao Carlos, University of Sao Paulo, Sao Carlos, Brazil.
authors.forename: Sérgio
authors.initials: S
authors.lastname: Mascarenhas
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002908:Chronic Disease; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D004833:Epilepsy, Temporal Lobe / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D006624:Hippocampus / Q000000981:diagnostic imaging* / Q000473:pathology; D007427:Intracranial Pressure / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D018721:Muscarinic Agonists / Q000633:toxicity; D009929:Organ Size; D010862:Pilocarpine / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013874:Thiopental / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D018721:Muscarinic Agonists; D010862:Pilocarpine; D013874:Thiopental
keywords: Epilepsy; ICP; ICP monitoring; Intracranial pressure; Pilocarpine