title: Automatic Three-dimensional Detection of Photoreceptor Ellipsoid Zone Disruption Caused by Trauma in the OCT.
abstract: Detection and assessment of the integrity of the photoreceptor ellipsoid zone (EZ) are important because it is critical for visual acuity in retina trauma and other diseases. We have proposed and validated a framework that can automatically analyse the 3D integrity of the EZ in optical coherence tomography (OCT) images. The images are first filtered and automatically segmented into 10 layers, of which EZ is located in the 7(th) layer. For each voxel of the EZ, 57 features are extracted and a principle component analysis is performed to optimize the features. An Adaboost classifier is trained to classify each voxel of the EZ as disrupted or non-disrupted. Finally, blood vessel silhouettes and isolated points are excluded. To demonstrate its effectiveness, the proposed framework was tested on 15 eyes with retinal trauma and 15 normal eyes. For the eyes with retinal trauma, the sensitivity (SEN) was 85.69% ± 9.59%, the specificity (SPE) was 85.91% ± 5.48%, and the balanced accuracy rate (BAR) was 85.80% ± 6.16%. For the normal eyes, the SPE was 99.03% ± 0.73%, and the SEN and BAR levels were not relevant. Our framework has the potential to become a useful tool for studying retina trauma and other conditions involving EZ integrity.
authors.affiliation: School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu, 215006, China.
authors.forename: Weifang
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, Guangdong, 515041, China.|Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong, Shatin N.T., Hong Kong, 999077, China.
authors.forename: Haoyu
authors.initials: H
authors.lastname: Chen
authors.affiliation: School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu, 215006, China.
authors.forename: Heming
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Tian
authors.affiliation: School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu, 215006, China.
authors.forename: Lirong
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu, 215006, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Shi
authors.affiliation: School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu, 215006, China.
authors.forename: Dehui
authors.initials: D
authors.lastname: Xiang
authors.affiliation: Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, Guangdong, 515041, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Luo
authors.affiliation: School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu, 215006, China.
authors.forename: Enting
authors.initials: E
authors.lastname: Gao
authors.affiliation: School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu, 215006, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Computer Science and Technology, Shandong University, Jinan, Shandong, 250100, China.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Yin
authors.affiliation: School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu, 215006, China.
authors.forename: Xinjian
authors.initials: X
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D001331:Automation; D002648:Child; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D010786:Photoreceptor Cells / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis*; D012171:Retinal Vessels / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*; D014947:Wounds and Injuries / Q000175:diagnosis*; D055815:Young Adult