title: Effects of medetomidine on serum glucose in cattle calves.
abstract: An experimental study was carried out to compare physiological effects (serum glucose level) of medetomidine in Red Sindhi cattle calves at three different doses i.e. 8, 10 and 12µg/kg body weight intravenously. Medetomidine produced a dose dependent significant (P<0.01) increase in serum glucose level with a maximum increase observed at 30 minutes with 8µg/kg, 10μg/kg and 12μg/kg body weight respectively. Start of sedation, degree of sedation and total duration of sedation were all dose dependent and the values obtained were significantly (P<0.01) different from each other. It was observed that the sedation was rapid, deep and longer with the higher doses of medetomidine i.e. 12μg/kg. The results of the present study shows that medetomidine is a very effective and safest drug use as sedative for calves which in lower doses (8μg/kg) can be used as a pre-anesthetic and for restraining of the animal, while higher calculated doses (10μg/kg, 12μg/kg) can be used to execute the minor surgical procedures.
authors.affiliation: Gomal College of Veterinary Sciences, Gomal University, D.I. Khan, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Tariq
authors.affiliation: Department of Surgery and Obstetrics, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University Tandojam, Pakistan.
authors.forename: Amir Bukhsh
authors.initials: AB
authors.lastname: Kalhoro
authors.affiliation: Department of Animal Health, Faculty of Animal Husbandry and Veterinary Sciences, The University of Agriculture, Peshawar, KPK, Pakistan.
authors.forename: Mian Saeed
authors.initials: MS
authors.lastname: Sarwar
authors.affiliation: Department of Animal Health, Faculty of Animal Husbandry and Veterinary Sciences, The University of Agriculture, Peshawar, KPK, Pakistan.
authors.forename: Hamayun
authors.initials: H
authors.lastname: Khan
authors.affiliation: Department of Animal Health, Faculty of Animal Husbandry and Veterinary Sciences, The University of Agriculture, Peshawar, KPK, Pakistan.
authors.forename: Shakoor
authors.initials: S
authors.lastname: Ahmad
authors.affiliation: Gomal College of Veterinary Sciences, Gomal University, D.I. Khan, Pakistan.
authors.forename: Sayed Mubashir
authors.initials: SM
authors.lastname: Hassan
authors.affiliation: Department of Animal Health, Faculty of Animal Husbandry and Veterinary Sciences, The University of Agriculture, Peshawar, KPK, Pakistan.
authors.forename: Arshad
authors.initials: A
authors.lastname: Zahoor
mesh_terms: D061605:Administration, Intravenous; D000367:Age Factors; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D002417:Cattle; D003243:Consciousness / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D020926:Medetomidine / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D013997:Time Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006993:Hypnotics and Sedatives; D020926:Medetomidine