title: Effects of Selective Agonists of V1a, V2, and V1b Receptors on Sodium Transport in Rat Kidney.
abstract: The role of subtypes of vasopressin receptors in modulation of renal sodium reabsorption was studied in in vivo experiments on Wistar rats. Selective V1a receptor agonist reduced sodium reabsorption in the kidneys and expression of these receptors increased by practically 100 times. This effect was similar to the effect of furosemide. Selective V2 receptor agonist enhanced sodium reabsorption in the kidney and simultaneously increased reabsorption of solute-free water. Stimulation of V1b receptors did not affect sodium transport. Our findings attest to the key role of V1a receptors in the regulation of renal excretion of sodium ions.
authors.affiliation: Laboratory of Renal Physiology and Water-Salt Balance, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Golosova
authors.affiliation: Laboratory of Renal Physiology and Water-Salt Balance, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Karavashkina
authors.affiliation: Laboratory of Renal Physiology and Water-Salt Balance, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kutina
authors.affiliation: Laboratory of Renal Physiology and Water-Salt Balance, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Marina
authors.affiliation: Laboratory of Renal Physiology and Water-Salt Balance, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia. natochin1@mail.ru.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Natochin
mesh_terms: D000818:Animals; D001692:Biological Transport; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D004232:Diuretics / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D017208:Rats, Wistar; D017483:Receptors, Vasopressin / Q000819:agonists*; D012964:Sodium / Q000378:metabolism*
chemical_list: D004232:Diuretics; D017483:Receptors, Vasopressin; D005665:Furosemide; D012964:Sodium; D003894:Deamino Arginine Vasopressin
keywords: kidney; reabsorption; sodium; vasopressin receptors