title: Differentiation of Basal Cell Carcinoma Subtypes in Multi-Beam Swept Source Optical Coherence Tomography (MSS-OCT).
abstract: BACKGROUND
  Optical coherence tomography (OCT) is a technique that enables real-time in-vivo examination of tissue. This technology provides the clinician with the potential to use a non-invasive tool in the identification and diagnosis of many skin lesions. However, the diagnostic features of basal cell carcinoma have not yet been described with comparison to their histopathology.<br />
  
  
  OBJECTIVE
  To identify and describe key features of basal cell carcinoma (BCC) and its subtypes as they present in multi-beam Swept Source - OCT (MSS-OCT), and to correlate those against conventional histopathology.<br/>
  
  
  METHODS
  A total of 40 lesions were assessed by MSS-OCT prior to biopsy. 60-slice OCT images of the lesions were obtained and correlated with histology sections taken in the same plane. OCT scans were assessed retrospectively by a panel to determine the OCT criteria for BCC and its subtypes.<br/>
  
  
  RESULTS
  The following diagnostic criteria were identified: hyporeflective ovoid structures (40/40), dark halo boundaries (38/40), epidermal thinning (28/40), and collagen compression (14/40). Lesional tissue also showed a destruction of layers when compared to the surrounding normal tissue. In addition to the shared criteria, other subtypes showed distinct diagnostic criteria.<br/>
  
  
  CONCLUSIONS
  With its higher sensitivity, using MSS-OCT allowed for non-invasive, accurate identification of the key diagnostic features of BCC and its subtypes with high correlation to the histopathologic features found with biopsy. <br /><br /> <em>J Drugs Dermatol. </em>2016;15(5):545-550.
authors.forename: Adam
authors.initials: A
authors.lastname: Meekings
authors.forename: Sarah
authors.initials: S
authors.lastname: Utz
authors.forename: Martina
authors.initials: M
authors.lastname: Ulrich
authors.forename: Amanda
authors.initials: A
authors.lastname: Bienenfeld
authors.forename: Naveen
authors.initials: N
authors.lastname: Nandanan
authors.forename: Juliya
authors.initials: J
authors.lastname: Fisher
authors.forename: Gordon
authors.initials: G
authors.lastname: McKenzie
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Siegel
authors.forename: Eleanor
authors.initials: E
authors.lastname: Feldman
authors.forename: Orit
authors.initials: O
authors.lastname: Markowitz
mesh_terms: D002280:Basal Cell Carcinoma / Q000145:classification* / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000145:classification* / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence / Q000379:methods*