title: Overexpression of GOLPH3 is associated with poor survival in Non-small-cell lung cancer.
abstract: As a highly conserved protein of the Golgi apparatus, Golgi phosphoprotein 3 (GOLPH3) has been shown to be involved in tumorigenesis. This study aims to explore the expression and significance of GOLPH3 in non-small-cell lung cancer (NSCLC). We found that GOLPH3 expression was significantly elevated in NSCLC tissues when compared with adjacent lung tissues (p<0.01). Moreover, GOLPH3 expression was significantly associated with histological type (p<0.01), differentiation (p<0.01), and lymph node metastasis (p<0.05). Kaplan-Meier survival analysis showed that overall survival of patients with high expression of GOLPH3 was significantly shorter (n=100, p<0.05). In addition, GOLPH3 knock-down in two independent NSCLC cell lines inhibited cell viability through the induction of cell cycle arrest and apoptosis. In conclusion, GOLPH3 is closely related to the progression in NSCLC and could be served as a potential prognostic biomarker and therapeutic target for NSCLC.
authors.affiliation: Department of Medical Oncology, Key Laboratory of Biotherapy in Zhejiang, Sir Runrun Shaw Hospital, Medical School of Zhejiang UniversityChina; Department of Medical Oncology, Jinhua Guangfu HospitalJinhua, China.
authors.forename: Wanfen
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Medical Oncology, Key Laboratory of Biotherapy in Zhejiang, Sir Runrun Shaw Hospital, Medical School of Zhejiang University China.
authors.forename: Mengjiao
authors.initials: M
authors.lastname: Han
authors.affiliation: Department of Medical Oncology, Key Laboratory of Biotherapy in Zhejiang, Sir Runrun Shaw Hospital, Medical School of Zhejiang University China.
authors.forename: Beihong
authors.initials: B
authors.lastname: Ruan
authors.affiliation: Department of Medical Oncology, Key Laboratory of Biotherapy in Zhejiang, Sir Runrun Shaw Hospital, Medical School of Zhejiang University China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jin
authors.affiliation: Department of Medical Oncology, Jinhua Guangfu Hospital Jinhua, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Lou
authors.affiliation: Department of Medical Oncology, Jinhua Guangfu Hospital Jinhua, China.
authors.forename: Xiamei
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Department of General Surgery, Sir Runrun Shaw Hospital, Medical School of Zhejiang University China.
authors.forename: Dingwei
authors.initials: D
authors.lastname: Chen
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong China.
authors.forename: Yangchao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Surgery, Faculty of Medicine, The University of Hong Kong China.
authors.forename: Vivian Y
authors.initials: VY
authors.lastname: Shin
authors.affiliation: Department of Medical Oncology, Key Laboratory of Biotherapy in Zhejiang, Sir Runrun Shaw Hospital, Medical School of Zhejiang University China.
authors.forename: Hongchuan
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Medical Oncology, Key Laboratory of Biotherapy in Zhejiang, Sir Runrun Shaw Hospital, Medical School of Zhejiang University China.
authors.forename: Xian
authors.initials: X
authors.lastname: Wang
keywords: GOLPH3; non-small-cell lung cancer