title: Clinical and electroencephalographic abnormalities during the full duration of a sporadic hemiplegic migraine attack.
abstract: Electroencephalographic (EEG) abnormalities have been reported during migraine attacks but their spatial and temporal distributions are not well known. We report the temporospatial dynamics of EEG during the full duration of a migraine attack with aura in a 19-year-old woman. She experienced episodes of hemiplegic migraine since the age of 2.5 years, with right hemibody paralysis preceded by visual symptoms. She reported severe pain of the right hemibody just before hemiplegia that was enventually suggestive of possible epileptic seizure, justifying diagnostic video-EEG monitoring. Sporadic hemiplegic migraine was diagnosed in the absence of family history. EEG was normal at the beginning of visual aura. After 15minutes, posterior slow waves appeared over the migrainous hemisphere, spreading progressively towards anterior regions: first the central region (5minutes after onset of contralateral hemiplegia), then the frontal region and over both hemispheres. A new de novo mutation was identified in the SCN1A gene.
authors.affiliation: Department of neurophysiology, Rouen university hospital-Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France; Inserm, U1075 Comete, université de Normandie, Caen, France. Electronic address: nathalie.chastan@chu-rouen.fr.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chastan
authors.affiliation: Department of neurophysiology, Rouen university hospital-Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: Axel
authors.initials: A
authors.lastname: Lebas
authors.affiliation: Department of neurophysiology, Rouen university hospital-Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: Floriane
authors.initials: F
authors.lastname: Legoff
authors.affiliation: Department of neurophysiology, Rouen university hospital-Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Parain
authors.affiliation: Department of neurophysiology, Rouen university hospital-Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Guyant-Marechal
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006429:Hemiplegia / Q000209:etiology*; D006801:Humans; D020325:Migraine with Aura / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology*; D009154:Mutation; D062550:NAV1.1 Voltage-Gated Sodium Channel / Q000235:genetics; D055815:Young Adult
chemical_list: D062550:NAV1.1 Voltage-Gated Sodium Channel; C568242:SCN1A protein, human
keywords: Electroencephalography; Migraine hémiplégique sporadique; SCN1A; Sporadic hemiplegic migraine; Électroencéphalographie