title: PREPARATION AND CHARACTERIZATION OF ORALLY DISINTEGRATING LORATADINE TABLETS MANUFACTURED WITH CO-PROCESSED MIXTURES.
abstract: The aim of this study was to develop orally disintegrated tablets (ODT) with loratadine using Parteck ODT and Ludiflash--new commercially available tableting excipients based on co-processed mannitol. ODT containing loratadine were prepared with 3% addition of various superdisintegrants (AcDiSol, Kollidon CL-F and Kollidon CL-SF) by direct compression method. Obtained tablets were characterized for friability, pore structure, and wetting and disintegration time measured by four independents methods. In order to identify possible interactions between loratadine and the excipients, differential scanning calorimetry was used. The results showed that all formulated ODT were characterized by appropriate mechanical properties (friability < 1%), the uniform content of the drug substance and pleasant mouth feeling. Disintegration time below 30 s was observed in formulations with crospovidones as disintegrant.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Amelian
authors.forename: Marta
authors.initials: M
authors.lastname: Szekalska
authors.forename: Agnieszka Zofia
authors.initials: AZ
authors.lastname: Wilczewska
authors.forename: Anna
authors.initials: A
authors.lastname: Basa
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Winnicka
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D005079:Excipients / Q000737:chemistry*; D006244:Hardness; D039563:Histamine H1 Antagonists, Non-Sedating / Q000008:administration & dosage* / Q000737:chemistry; D007700:Kinetics; D017336:Loratadine / Q000008:administration & dosage* / Q000737:chemistry; D016062:Porosity; D011205:Povidone / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013649:Taste; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D005079:Excipients; D039563:Histamine H1 Antagonists, Non-Sedating; D013607:Tablets; D017336:Loratadine; D011205:Povidone