title: IKZF1 alterations and expression of CRLF2 predict prognosis in adult Chinese patients with B-cell precursor acute lymphoblastic leukemia.
abstract: Acute Lymphoblastic Leukemia (ALL) is a common hematological malignancy in children, with a prognosis much worse in adults. The molecular characterization of ALL and its correlated prognostic significance are largely unknown. In this study, we analyzed the frequency of IKZF1 deletions, IK6 isoform, and CRLF2 overexpression in 118 Chinese adult B-cell precursor ALL (B-ALL) patients to explore their associations with clinical prognosis. Our data showed that IKZF1 deletions and IK6 isoform were highly detected in adult patients, and both of them were related with worse prognosis in Ph-B-ALL, HR group of Ph-B-ALL, and/or B-ALL patients. Though the frequency of CRLF2 overexpression was similar to children, it had an independent prognostic significance for standard-risk and Ph-adult patients. Our study provided insights into the prognostic significance of certain genetic features in B-ALL patients. Further therapeutic strategies targeting these abnormalities potentially improving the prognosis of B-ALL are warranted.
authors.affiliation: a State Key Laboratory of Experimental Hematology , Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , PR China.
authors.forename: Qiuyun
authors.initials: Q
authors.lastname: Fang
authors.affiliation: a State Key Laboratory of Experimental Hematology , Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , PR China.
authors.forename: Xingli
authors.initials: X
authors.lastname: Zhao
authors.affiliation: a State Key Laboratory of Experimental Hematology , Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , PR China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Experimental Hematology , Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Experimental Hematology , Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , PR China.
authors.forename: Kaiqi
authors.initials: K
authors.lastname: Liu
authors.affiliation: a State Key Laboratory of Experimental Hematology , Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , PR China.
authors.forename: Kejing
authors.initials: K
authors.lastname: Tang
authors.affiliation: a State Key Laboratory of Experimental Hematology , Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a State Key Laboratory of Experimental Hematology , Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , PR China.
authors.forename: Bingcheng
authors.initials: B
authors.lastname: Liu
authors.affiliation: a State Key Laboratory of Experimental Hematology , Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: a State Key Laboratory of Experimental Hematology , Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , PR China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Xing
authors.affiliation: a State Key Laboratory of Experimental Hematology , Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , PR China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Rao
authors.affiliation: a State Key Laboratory of Experimental Hematology , Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , PR China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Tian
authors.affiliation: a State Key Laboratory of Experimental Hematology , Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , PR China.
authors.forename: Jianxiang
authors.initials: J
authors.lastname: Wang
authors.affiliation: a State Key Laboratory of Experimental Hematology , Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , PR China.
authors.forename: Yingchang
authors.initials: Y
authors.lastname: Mi
mesh_terms: D000293:Adolescent; D000328:Adult; D017398:Alternative Splicing; D014408:Biomarkers, Tumor; D005260:Female; D017353:Gene Deletion; D015870:Gene Expression; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D051740:Ikaros Transcription Factor / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality*; D011379:Prognosis; D018121:Receptors, Cytokine / Q000235:genetics*; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C498762:CRLF2 protein, human; C497239:IKZF1 protein, human; C586512:Ikaros 6 protein, human; D018121:Receptors, Cytokine; D051740:Ikaros Transcription Factor
keywords: Acute Lymphoblastic Leukemia; CRLF2; IK6; IKZF1; adult