title: Production and in vivo imaging of (203)Pb as a surrogate isotope for in vivo (212)Pb internal absorbed dose studies.
abstract: (212)Pb is a clinically relevant therapeutic alpha emitter isotope. A surrogate, (203)Pb, if prepared with sufficiently high specific activity could be used to estimate (212)Pb in vivo absorbed doses. An improved production procedure of (203)Pb with a simple, new separation method and high specific radioactivity for imaging is reported. We determined the in-vivo biodistribution of (203)Pb in mice by SPECT/CT. This highlights application possibilities of (203)Pb for further in vivo and clinical uses (radiolabeled (212)Pb-peptide co-injection, dosimetry calculation).
authors.affiliation: CROmed Research Centers Ltd., Baross utca 91-95, H-1047 Budapest, Hungary. Electronic address: domokos.mathe@cromedresearch.com.
authors.forename: Domokos
authors.initials: D
authors.lastname: Máthé
authors.affiliation: Dept. of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó utca 37-47, H-1094 Budapest, Hungary. Electronic address: szigeti.krisztian@med.semmelweis-univ.hu.
authors.forename: Krisztián
authors.initials: K
authors.lastname: Szigeti
authors.affiliation: Dept. of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó utca 37-47, H-1094 Budapest, Hungary. Electronic address: hegedus.nikolett@med.semmelweis-univ.hu.
authors.forename: Nikolett
authors.initials: N
authors.lastname: Hegedűs
authors.affiliation: Dept. of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó utca 37-47, H-1094 Budapest, Hungary. Electronic address: horvath.ildiko@med.semmelweis-univ.hu.
authors.forename: Ildikó
authors.initials: I
authors.lastname: Horváth
authors.affiliation: Dept. of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó utca 37-47, H-1094 Budapest, Hungary. Electronic address: veres.daniel@med.semmelweis-univ.hu.
authors.forename: Dániel S
authors.initials: DS
authors.lastname: Veres
authors.affiliation: Institute of Food Science, University of Debrecen, Böszörményi út 138, H-4032 Debrecen, Hungary. Electronic address: kovacsb@agr.unideb.hu.
authors.forename: Béla
authors.initials: B
authors.lastname: Kovács
authors.affiliation: Dept. of Cyclotron Application, MTA Atomki, Bem tér 18/c, H-4026 Debrecen, Hungary. Electronic address: zszucs@atomki.mta.hu.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szűcs
mesh_terms: D000818:Animals; D006801:Humans; D007856:Lead Radioisotopes / Q000302:isolation & purification* / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009369:Neoplasms / Q000532:radiotherapy; D011829:Radiation Dosage; D011874:Radiometry; D011878:Radiotherapy / Q000379:methods; D000072098:Single Photon Emission Computed Tomography Computed Tomography; D014018:Tissue Distribution
chemical_list: D007856:Lead Radioisotopes; C000615121:Lead-203; C000615125:Lead-212
keywords: (203)Pb; (212)Pb; Gamma-emitting isotope; NanoSPECT/CT; Targeted alpha therapy