title: STUDY OF DUAL MATRIX TABLETS CONTAINING HYPROMELLOSE OF DIFFERENT VISCOSITY DEGREE AND GLYCERYL DIBEHENATE.
abstract: Studies are described on the compressibility of directly compressible tableting materials containing two viscosity types of hypromellose in two concentrations and tableting materials containing additional glyceryl dibehenate, also in two concentrations. Compressibility is evaluated by means of the energy profile of the compression process and determination of tensile strength of tablets. Dissolution test examines the rate of release of the active ingredient from matrix tablets, which is subsequently evaluated mathematically. Increased concentrations of both hypromelloses and an addition of glyceryl dibehenate into tablets with both types of hypromellose improved compressibility. The rate of drug release was decreased with increasing viscosity degree of hypromellose and its increasing concentration. An addition of glyceryl dibehenate exerted the same influence on release as increased concentrations of the pertinent hypromellose.
authors.forename: Jitka
authors.initials: J
authors.lastname: Mužíková
authors.forename: Katerina
authors.initials: K
authors.lastname: Holubová
authors.forename: Alena
authors.initials: A
authors.lastname: Komersová
authors.forename: Václav
authors.initials: V
authors.lastname: Lochar
mesh_terms: D002626:Chemistry, Pharmaceutical; D019245:Compressive Strength; D005079:Excipients / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry; D065347:Hypromellose Derivatives / Q000737:chemistry*; D007700:Kinetics; D008956:Models, Chemical; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods; D013718:Tensile Strength; D014783:Viscosity
chemical_list: D005079:Excipients; D005227:Fatty Acids; D013607:Tablets; D065347:Hypromellose Derivatives