title: Optimal graft source for allogeneic hematopoietic stem cell transplant: bone marrow or peripheral blood?
abstract: Peripheral blood (PB), compared with bone marrow graft, has higher stem cell content, leads to faster engraftment and is more convenient for collection. Consequently, the use of PB graft has significantly increased in recent years. Although the use of PB graft is acceptable or even preferred to bone marrow graft in matched related donor allogeneic transplant due to a possibility of improved survival, PB graft increases the risk of chronic graft-versus-host disease and associated long-term toxicities in the setting of matched unrelated donor allogeneic transplant. In haploidentical transplant, mitigation of graft-versus-host disease with the use of post-transplant cyclophosphamide is a hypothesis-generating possibility; however, available studies have significant limitations to draw any definite conclusion.
authors.affiliation: Department of Medicine, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.
authors.forename: Janak
authors.initials: J
authors.lastname: Adhikari
authors.affiliation: Department of Medicine, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.
authors.forename: Priyadarshani
authors.initials: P
authors.lastname: Sharma
authors.affiliation: Department of Internal Medicine, Division of Hematology-Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
authors.forename: Vijaya Raj
authors.initials: VR
authors.lastname: Bhatt
mesh_terms: D016026:Bone Marrow Transplantation; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D036102:Peripheral Blood Stem Cell Transplantation; D014184:Transplantation, Homologous / Q000379:methods*
keywords: allogeneic hematopoietic stem cell transplantation; graft source; graft-versus-host disease; survival