title: (-)-Epigallocatechin-3-gallate (EGCG) attenuates arsenic-induced cardiotoxicity in rats.
abstract: Chronic arsenic exposure in drinking water is associated with the abnormalities of cardiac tissue. Excessive generation of ROS induced by arsenic has a central role in arsenic-induced cardiotoxicity. (-)-Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, possesses a potent antioxidant capacity and exhibits extensive pharmacological activities. This study was aim to evaluate the effect of EGCG on arsenic-induced cardiotoxicity in vivo and in vitro. Treatment with NaAsO2 seriously affected the morphology and ultrastructure of myocardium, and induced cardiac injuries, oxidative stress, intracellular calcium accumulation and apoptosis in rats. In consistent with in vivo study, the injuries, oxidative stress and apoptosis were also observed in NaAsO2-treated H9c2 cells. All of these effects induced by NaAsO2 were attenuated by EGCG. These results suggest EGCG could attenuate NaAsO2-induced cardiotoxicity, and the mechanism may involve its potent antioxidant capacity.
authors.affiliation: Department of Pharmacology, Xiangnan College, Chenzhou, Hunan, 423000, China.
authors.forename: Tao-Li
authors.initials: TL
authors.lastname: Sun
authors.affiliation: Department of Pharmacology, Guizhou Medical University, Guiyang, Guizhou, 550004, China; Department of Urology Surgery and Oncology, The Second Affiliated Hospital of Guizhou Medical University, Kaili, Guizhou, 556000, China; Department of Histology and Embryology, Guizhou Medical University, Guiyang, Guizhou, 550004, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Urology Surgery and Oncology, The Second Affiliated Hospital of Guizhou Medical University, Kaili, Guizhou, 556000, China.
authors.forename: Zheng-Jun
authors.initials: ZJ
authors.lastname: Qi
authors.affiliation: Department of Pharmacology, Guizhou Medical University, Guiyang, Guizhou, 550004, China; Department of Pharmacology, Central South University, Changsha, Hunan, 410078, China. Electronic address: yongpanhuangxy@aliyun.com.
authors.forename: Yong-Pan
authors.initials: YP
authors.lastname: Huang
authors.affiliation: Department of Histology and Embryology, Guizhou Medical University, Guiyang, Guizhou, 550004, China.
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Gao
authors.affiliation: Department of Pharmacology, Guizhou Medical University, Guiyang, Guizhou, 550004, China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001151:Arsenic / Q000633:toxicity*; D002118:Calcium / Q000378:metabolism; D066126:Cardiotoxicity / Q000209:etiology / Q000517:prevention & control*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000473:pathology*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000975:Antioxidants; D002392:Catechin; C045651:epigallocatechin gallate; D001151:Arsenic; D002118:Calcium
keywords: (-)-Epigallocatechin-3-gallate (EGCG); Arsenic; Cardiotoxicity; NaAsO(2); Oxidative stress