title: Cardiac Strain in a Swine Model of Regional Hibernating Myocardium: Effects of CoQ10 on Contractile Reserve Following Bypass Surgery.
abstract: There is conflicting clinical evidence whether administration of coenzyme Q10 (CoQ10) improves function following coronary artery bypass graft surgery (CABG). Using a swine model of hibernating myocardium, we tested whether daily CoQ10 would improve contractile function by MRI at 4-week post-CABG. Twelve pigs underwent a thoracotomy and had a constrictor placed on the left anterior descending (LAD). At 12 weeks, they underwent off-pump bypass and received daily dietary supplements of either CoQ10 (10 mg/kg/day) or placebo. At 4-week post-CABG, circumferential strain measurements in the hibernating LAD region from placebo and CoQ10 groups were not different and increased to a similar extent with dobutamine (-14.7 ± 0.6 versus -14.8 ± 0.1, respectively (NS)). Post-sacrifice, oxidant stress markers were obtained in the mitochondrial isolates and protein carbonyl in the placebo, and CoQ10 groups were 6.14 ± 0.36 and 5.05 ± 0.32 nmol/mg, respectively (NS). In summary, CoQ10 did not improve contractile reserve or reduce oxidant stress at 4-week post-CABG.
authors.affiliation: Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Hocum Stone
authors.affiliation: Research Minneapolis VAHCS, Minneapolis, MN, 55417, USA.|Department of Food Science and Nutrition, University of Minnesota, Saint Paul, Minneapolis, MN, 55108, USA.|University of Minnesota Nutrition and Obesity Center, Saint Paul, Minneapolis, MN, 55108, USA.
authors.forename: Tammy A
authors.initials: TA
authors.lastname: Butterick
authors.affiliation: Research Minneapolis VAHCS, Minneapolis, MN, 55417, USA.|Department of Food Science and Nutrition, University of Minnesota, Saint Paul, Minneapolis, MN, 55108, USA.
authors.forename: Cayla
authors.initials: C
authors.lastname: Duffy
authors.affiliation: Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Corey
authors.initials: C
authors.lastname: Swingen
authors.affiliation: Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Herbert B
authors.initials: HB
authors.lastname: Ward
authors.affiliation: Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Rosemary F
authors.initials: RF
authors.lastname: Kelly
authors.affiliation: Department of Surgery, University of Minnesota, Minneapolis, MN, USA. mcfal001@umn.edu.|Cardiology (111C), VA Medical Center, 1 Veterans Drive, Minneapolis, MN, 55417, USA. mcfal001@umn.edu.
authors.forename: Edward O
authors.initials: EO
authors.lastname: McFalls
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001696:Biomechanical Phenomena; D002316:Cardiotonic Agents / Q000494:pharmacology*; D047549:Coronary Artery Bypass, Off-Pump; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D004195:Disease Models, Animal; D005260:Female; D008279:Magnetic Resonance Imaging; D008929:Mitochondria, Heart / Q000378:metabolism; D009200:Myocardial Contraction / Q000187:drug effects*; D017682:Myocardial Stunning / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress; D050050:Protein Carbonylation; D020127:Recovery of Function; D013314:Stress, Mechanical; D034421:Sus scrofa; D013997:Time Factors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D015415:Biomarkers; D002316:Cardiotonic Agents; D014451:Ubiquinone; C024989:coenzyme Q10
keywords: Bypass surgery; Chronically ischemic myocardium; Contractile reserve; Hibernating myocardium; MRI; Mitochondria; Oxidant stress