title: PepPSy: a web server to prioritize gene products in experimental and biocuration workflows.
abstract: Among the 20 000 human gene products predicted from genome annotation, about 3000 still lack validation at protein level. We developed PepPSy, a user-friendly gene expression-based prioritization system, to help investigators to determine in which human tissues they should look for an unseen protein. PepPSy can also be used by biocurators to revisit the annotation of specific categories of proteins based on the 'omics' data housed by the system. In this study, it was used to prioritize 21 dubious protein-coding genes among the 616 annotated in neXtProt for reannotation. PepPSy is freely available at http://peppsy.genouest.orgDatabase URL: http://peppsy.genouest.org.
authors.affiliation: Genouest Bioinformatics Platform, IRISA, Campus de Beaulieu, Rennes 35042, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Sallou
authors.affiliation: CALIPHO Group, SIB Swiss Institute of Bioinformatics, CMU, Michel Servet 1, Geneva 1211, Switzerland.
authors.forename: Paula D
authors.initials: PD
authors.lastname: Duek
authors.affiliation: Genouest Bioinformatics Platform, IRISA, Campus de Beaulieu, Rennes 35042, France IRSET, Inserm U1085, 9 avenue du Professeur Léon Bernard, Rennes 35000, France.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Darde
authors.affiliation: Genouest Bioinformatics Platform, IRISA, Campus de Beaulieu, Rennes 35042, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Collin
authors.affiliation: CALIPHO Group, SIB Swiss Institute of Bioinformatics, CMU, Michel Servet 1, Geneva 1211, Switzerland Department of Human Protein Sciences, Faculty of Medicine, University of Geneva, CMU, Michel Servet 1, Geneva 1211, Switzerland.
authors.forename: Lydie
authors.initials: L
authors.lastname: Lane
authors.affiliation: IRSET, Inserm U1085, 9 avenue du Professeur Léon Bernard, Rennes 35000, France frederic.chalmel@inserm.fr.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Chalmel
mesh_terms: D019295:Computational Biology; D003628:Database Management Systems; D030541:Databases, Genetic; D006801:Humans; D020407:Internet; D058977:Molecular Sequence Annotation; D011506:Proteins / Q000235:genetics*; D014584:User-Computer Interface; D057188:Workflow
chemical_list: D011506:Proteins