title: Admission Endocan Level may be a Useful Predictor for In-Hospital Mortality and Coronary Severity Index in Patients With ST-Segment Elevation Myocardial Infarction.
abstract: We assessed the prognostic role of serum endocan level in patients with ST-segment elevation myocardial infarction (STEMI) and compared the results with a normal coronary angiography group. A total of 133 patients were included in the study (88 patients with STEMI and 45 patients with normal coronary arteries). The SYNTAX score was determined based on the baseline coronary angiogram. Multivariate logistic regression analysis indicated that endocan independently correlated with the presence of STEMI. Moreover, high-sensitivity C-reactive protein (hsCRP), peak troponin I, and left ventricular ejection fraction (LVEF) were found to be independently associated with STEMI. Endocan level correlated significantly with hsCRP and SYNTAX score. We analyzed the discriminatory capability of endocan level for the presence of STEMI using a receiver-operating characteristics curve. A cutoff endocan level of 1.7 (ng/mL) predicted the presence of STEMI with a sensitivity of 76.1% and specificity of 73.6%. In conclusion, a high endocan level on hospital admission is an independent predictor of a worse cardiovascular outcome and a high SYNTAX score in patients with STEMI.
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey harunkundi@hotmail.com.
authors.forename: Harun
authors.initials: H
authors.lastname: Kundi
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Balun
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Cicekcioglu
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Karayigit
authors.affiliation: Department of Biochemistry, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Topcuoglu
authors.affiliation: Department of Biochemistry, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Muhammed Fevzi
authors.initials: MF
authors.lastname: Kilinckaya
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Emrullah
authors.initials: E
authors.lastname: Kiziltunc
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cetin
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Ender
authors.initials: E
authors.lastname: Ornek
mesh_terms: D000368:Aged; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality*; D009363:Neoplasm Proteins / Q000097:blood*; D062645:Percutaneous Coronary Intervention / Q000401:mortality; D011509:Proteoglycans / Q000097:blood*; D012372:ROC Curve; D018570:Risk Assessment / Q000379:methods; D000072657:ST Elevation Myocardial Infarction / Q000175:diagnosis / Q000401:mortality*; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans
keywords: STEMI; SYNTAX score; endocan; inflammation