title: Normal gray matter volumes in women recovered from anorexia nervosa: a voxel-based morphometry study.
abstract: BACKGROUND
  Anorexia nervosa (AN) has consistently been associated with reduced gray (GM) and white matter (WM) brain volumes. It is unclear whether GM alterations are present following recovery from AN, as previous findings are inconsistent. The aim of the present study was to determine if women recovered from AN exhibit reduced global or regional GM volumes.
  
  
  METHODS
  Global GM and WM, as well as regional GM volumes, were investigated in 22 women recovered from AN and 22 age-matched healthy controls using magnetic resonance imaging. Women were considered recovered if they had maintained a body mass index above 18.0 and had not engaged in binge eating, purging, or restrictive eating behaviors during the past year.
  
  
  RESULTS
  There were no significant differences between recovered AN women and healthy controls in terms of GM and WM volumes. There were also no significant differences between restricting and binging-purging AN subtypes. Lowest lifetime weight was positively correlated with regional GM volumes in the precuneus and insula.
  
  
  CONCLUSIONS
  The present study showed that regional GM and global GM and WM volumes were similar for women long-term recovered from AN and age-matched healthy controls. Further research is needed to determine the extent to which illness severity affect regional GM volumes.
authors.affiliation: Regional Department for Eating Disorders, Division of Mental Health and Addiction, Oslo University Hospital, P.O. Box 4956, Nydalen, 0424, Oslo, Norway. Lasse.Bang@ous-hf.no.
authors.forename: Lasse
authors.initials: L
authors.lastname: Bang
authors.affiliation: Regional Department for Eating Disorders, Division of Mental Health and Addiction, Oslo University Hospital, P.O. Box 4956, Nydalen, 0424, Oslo, Norway.|Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, P.O. Box 1171, Blindern, 0318, Oslo, Norway.
authors.forename: Øyvind
authors.initials: Ø
authors.lastname: Rø
authors.affiliation: Institute of Psychology, University of Oslo, P.O. Box 1094, Blindern, 0317, Oslo, Norway.
authors.forename: Tor
authors.initials: T
authors.lastname: Endestad
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000534:rehabilitation*; D015992:Body Mass Index; D001931:Brain Mapping / Q000379:methods; D005260:Female; D066128:Gray Matter / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009929:Organ Size
keywords: Anorexia nervosa; Gray matter; Magnetic resonance imaging; Structural brain alterations; Voxel based morphometry