title: Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil.
abstract: BACKGROUND
  Cyclosporine and tacrolimus are well established immunosuppressants; however little is known about long term survival rates. The project aim was to compare 10-year graft survival and associated factors among kidney transplant patients within the Brazilian Public Health System (SUS) prescribed either immunosuppressant.
  
  
  METHODS
  Analyze a national cohort of kidney transplant recipients within SUS. Graft loss defined by death or dialysis for more than three months. Kaplan-Meier method used to estimate cumulative probabilities of survival. Cox proportional hazards model used to evaluate factors associated with progression to graft loss.
  
  
  RESULTS
  13,811 patients were included, 5,887 used cyclosporine and 7,924 tacrolimus. A higher risk of graft loss was associated with tacrolimus, a deceased donor, additional years of age, median period of dialysis greater than 47 months, diagnosis of diabetes as the primary cause of chronic kidney disease and transplantation between 2005 and 2009.
  
  
  CONCLUSIONS
  Among other factors, tacrolimus-based regimens were associated with worse graft survival.
authors.affiliation: a Post-Graduation Program in Medicines and Pharmaceutical Assistance, Department of Social Pharmacy , College of Pharmacy, Federal University of Minas Gerais , Minas Gerais , Brazil.|b SUS Collaborating Centre - Technology Assessment & Excellence in Health, College of Pharmacy , Federal University of Minas Gerais , Minas Gerais , Brazil.
authors.forename: Rosângela Maria
authors.initials: RM
authors.lastname: Gomes
authors.affiliation: a Post-Graduation Program in Medicines and Pharmaceutical Assistance, Department of Social Pharmacy , College of Pharmacy, Federal University of Minas Gerais , Minas Gerais , Brazil.|b SUS Collaborating Centre - Technology Assessment & Excellence in Health, College of Pharmacy , Federal University of Minas Gerais , Minas Gerais , Brazil.
authors.forename: Augusto Afonso
authors.initials: AA
authors.lastname: Guerra Júnior
authors.affiliation: b SUS Collaborating Centre - Technology Assessment & Excellence in Health, College of Pharmacy , Federal University of Minas Gerais , Minas Gerais , Brazil.|c Post-Graduation Program in Public Health, Department of Preventive and Social Medicine, College of Medicine , Federal University of Minas Gerais , Minas Gerais , Brazil.
authors.forename: Lívia Lovato Pires de
authors.initials: LL
authors.lastname: Lemos
authors.affiliation: c Post-Graduation Program in Public Health, Department of Preventive and Social Medicine, College of Medicine , Federal University of Minas Gerais , Minas Gerais , Brazil.
authors.forename: Juliana de Oliveira
authors.initials: Jde O
authors.lastname: Costa
authors.affiliation: a Post-Graduation Program in Medicines and Pharmaceutical Assistance, Department of Social Pharmacy , College of Pharmacy, Federal University of Minas Gerais , Minas Gerais , Brazil.|b SUS Collaborating Centre - Technology Assessment & Excellence in Health, College of Pharmacy , Federal University of Minas Gerais , Minas Gerais , Brazil.
authors.forename: Alessandra Maciel
authors.initials: AM
authors.lastname: Almeida
authors.affiliation: a Post-Graduation Program in Medicines and Pharmaceutical Assistance, Department of Social Pharmacy , College of Pharmacy, Federal University of Minas Gerais , Minas Gerais , Brazil.|b SUS Collaborating Centre - Technology Assessment & Excellence in Health, College of Pharmacy , Federal University of Minas Gerais , Minas Gerais , Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Alvares
authors.affiliation: d Department of Surgery , College of Medicine, Federal University of Minas Gerais , Minas Gerais , Brazil.
authors.forename: Charles Simão
authors.initials: CS
authors.lastname: Filho
authors.affiliation: c Post-Graduation Program in Public Health, Department of Preventive and Social Medicine, College of Medicine , Federal University of Minas Gerais , Minas Gerais , Brazil.
authors.forename: Mariângela Leal
authors.initials: ML
authors.lastname: Cherchiglia
authors.affiliation: c Post-Graduation Program in Public Health, Department of Preventive and Social Medicine, College of Medicine , Federal University of Minas Gerais , Minas Gerais , Brazil.
authors.forename: Eli Iola Gurgel
authors.initials: EI
authors.lastname: Andrade
authors.affiliation: e Strathclyde Institute of Pharmacy and Biomedical Sciences , University of Strathclyde , Glasgow , United Kingdom.|f Division of Clinical Pharmacology , Karolinska Institute , Stockholm , Sweden.
authors.forename: Brian
authors.initials: B
authors.lastname: Godman
authors.affiliation: a Post-Graduation Program in Medicines and Pharmaceutical Assistance, Department of Social Pharmacy , College of Pharmacy, Federal University of Minas Gerais , Minas Gerais , Brazil.|b SUS Collaborating Centre - Technology Assessment & Excellence in Health, College of Pharmacy , Federal University of Minas Gerais , Minas Gerais , Brazil.
authors.forename: Francisco Assis
authors.initials: FA
authors.lastname: Acurcio
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001938:Brazil; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D006435:Renal Dialysis / Q000379:methods; D051436:Renal Insufficiency, Chronic / Q000209:etiology / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D016559:Tacrolimus / Q000627:therapeutic use*; D013997:Time Factors; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus
keywords: Brazil; cyclosporine; graft survival; immunosuppressants; kidney transplantation; survival rates; tacrolimus