title: Early Changes in Cortical Emotion Processing Circuits after Mild Traumatic Brain Injury from Motor Vehicle Collision.
abstract: Mild traumatic brain injury (mTBI) patients frequently experience emotion dysregulation symptoms, including post-traumatic stress. Although mTBI likely affects cortical activation and structure, resulting in cognitive symptoms after mTBI, early effects of mTBI on cortical emotion processing circuits have rarely been examined. To assess early mTBI effects on cortical functional and structural components of emotion processing, we assessed cortical activation to fearful faces within the first 2 weeks after motor vehicle collision (MVC) in survivors who did and did not experience mTBI. We also examined the thicknesses of cortical regions with altered activation. MVC survivors with mTBI (n = 21) had significantly less activation in left superior parietal gyrus (SPG) (-5.9, -81.8, 33.8; p = 10-3.623), left medial orbitofrontal gyrus (mOFG) (-4.7, 36.1, -19.3; p = 10-3.231), and left and right lateral orbitofrontal gyri (lOFG) (left: -16.0, 41.4, -16.6; p = 10-2.573; right: 18.7, 22.7, -17.7; p = 10-2.764) than MVC survivors without mTBI (n = 23). SPG activation in mTBI survivors within 2 weeks after MVC was negatively correlated with subsequent post-traumatic stress symptom severity at 3 months (r = -0.68, p = 0.03). Finally, the SPG region was thinner in the mTBI survivors than in the non-mTBI survivors (F = 11.07, p = 0.002). These results suggest that early differences in activation and structure in cortical emotion processing circuits in trauma survivors who sustain mTBI may contribute to the development of emotion-related symptoms.
authors.affiliation: 1 Department of Psychiatry, University of Toledo , Toledo, Ohio.|2 Department of Neurosciences, University of Toledo , Toledo, Ohio.|3 Department of Radiology, University of Toledo , Toledo, Ohio.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: 2 Department of Neurosciences, University of Toledo , Toledo, Ohio.
authors.forename: Hong
authors.initials: H
authors.lastname: Xie
authors.affiliation: 1 Department of Psychiatry, University of Toledo , Toledo, Ohio.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Cotton
authors.affiliation: 4 Department of Emergency Medicine, University of Toledo , Toledo, Ohio.
authors.forename: Kristopher R
authors.initials: KR
authors.lastname: Brickman
authors.affiliation: 3 Department of Radiology, University of Toledo , Toledo, Ohio.
authors.forename: Terrence J
authors.initials: TJ
authors.lastname: Lewis
authors.affiliation: 2 Department of Neurosciences, University of Toledo , Toledo, Ohio.
authors.forename: John T
authors.initials: JT
authors.lastname: Wall
authors.affiliation: 1 Department of Psychiatry, University of Toledo , Toledo, Ohio.
authors.forename: Marijo B
authors.initials: MB
authors.lastname: Tamburrino
authors.affiliation: 2 Department of Neurosciences, University of Toledo , Toledo, Ohio.
authors.forename: William R
authors.initials: WR
authors.lastname: Bauer
authors.affiliation: 1 Department of Psychiatry, University of Toledo , Toledo, Ohio.
authors.forename: Kenny
authors.initials: K
authors.lastname: Law
authors.affiliation: 5 Department of Anesthesiology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
authors.forename: Samuel A
authors.initials: SA
authors.lastname: McLean
authors.affiliation: 6 Department of Psychiatry, University of Michigan , Ann Arbor, Michigan.
authors.forename: Israel
authors.initials: I
authors.lastname: Liberzon
mesh_terms: D000063:Accidents, Traffic / Q000523:psychology* / Q000639:trends; D000328:Adult; D001924:Brain Concussion / Q000000981:diagnostic imaging* / Q000523:psychology*; D004644:Emotions / Q000502:physiology; D005149:Facial Expression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000639:trends; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000000981:diagnostic imaging* / Q000502:physiology; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging*; D055815:Young Adult
keywords: MRI, TBI; human studies