title: TLR2 and TLR4 polymorphisms in Southern Chinese Psoriasis Vulgaris patients.
abstract: BACKGROUND
  The toll-like receptors-(TLR)-2 and -4 play a role in the innate immune system and drive the autoimmune T cell cascade in psoriasis. But little is known about the association of the polymorphisms of TLR2/TLR4 and psoriasis vulgaris (PsV).
  
  
  METHODS
  We performed a hospital-based association study involved in355 PsV patients and 213 controls. Genotyping of 11 SNPs rs4696480(-16934A/T), rs121917864 (2029C/T;Arg677Trp), rs5743708 (2408G/A;Arg753Gln), rs3804099 (+597T/C), rs5743699(+1349T/C) of TLR2 on chromosome 4q32; and rs1927914 (-6143A/G), rs10759932(-5724T/C), rs4986790 (896A/G; Asp299Gly), rs4986791 (1196C/T; Thr399lle); rs11536889(+7263G/C), rs11536891(+8469T/C) of TLR4 on chromosome 9q33.1 were determined using SNaPshot Multiplex Kit (Applied Biosystems Co., USA).
  
  
  RESULTS
  We did not detect the presence of any of the five rare SNPs (rs5743708, rs121917864, rs5743699, rs4986790, rs4986791). The comparison of allele distributions revealed that only one SNP (rs3804099) of 6 common SNPs(rs10759932, rs11536889, rs11536891, rs1927914, rs3804099, rs4696480) was significant associated with the risk of PsV (P<0.01; FDR p-Value). However, there were no significant differences found in other subphenotypes of family history or PASI between patients positive and those negative for a particular phenotype.
  
  
  CONCLUSIONS
  The SNP rs3804099 of TLR2 may have significant effects on heritability of PsV in our Chinese population. TLR2 and its pathway might take part in the pathogenesis of PsV.
authors.affiliation: Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Shi
authors.affiliation: Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China.
authors.forename: Shijie
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Sheng
authors.affiliation: Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China; First Affiliated Hospital and Institute of Mycology, Jinan University, Guangzhou, Guangdong, China. Electronic address: zhukunju1111@163.com.
authors.forename: KunJu
authors.initials: K
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D012306:Risk; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D055815:Young Adult
chemical_list: C495342:TLR2 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4
keywords: Clinical features; Polymorphism; Psoriasis vulgaris; TLR2; TLR4; Toll-like receptors