title: Trigeminal Cardiac Reflex Caused by Onyx Embolization of Intracranial Dural Arteriovenous Fistula.
abstract: Trigeminocardiac reflex (TCR) is a reflexive response of bradycardia, hypotension and gastric hypermotility which is observed upon mechanical stimulation in the distribution of the trigeminal nerve. Previous articles have described TCR during intracranial operations, ophthalmic surgery, microcompression of the trigeminal ganglion and radiofrequency lesioning of the trigeminal ganglion. TCR may occur during transarterial embolization of dural arteriovenous fistula (DAVF) with Onyx, leading to a significant decrease in heart rate under a standard anesthetic protocol. TCR may also occur due to chemical stimulus of dimethyl sulfoxide (DMSO) in transvenous Onyx embolization of dural cavernous sinus fistula. Slow rate of injection may give DMSO enough time to dissipate in the blood stream which is important for the prevention of toxicity. This report confirms that the reflex was blunted by the anticholinergic effects of atropine and there was no harm to patients if stopped immediately.
authors.affiliation: China-Japan Union Hospital of Jilin University, The Second Department of Neurosurgery, Changchun City, JiLin Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Huan-Cheng
authors.initials: HC
authors.lastname: Wu
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Wang
authors.forename: Hong-Sen
authors.initials: HS
authors.lastname: Zhao
authors.forename: Ri-Na
authors.initials: RN
authors.lastname: Dao
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Liu
authors.forename: Dong-Zhe
authors.initials: DZ
authors.lastname: Zhou
authors.forename: Hui-Yu
authors.initials: HY
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: DU
mesh_terms: D001285:Atropine / Q000494:pharmacology; D020785:Central Nervous System Vascular Malformations / Q000150:complications / Q000628:therapy; D004121:Dimethyl Sulfoxide / Q000009:adverse effects*; D004621:Embolization, Therapeutic / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011145:Polyvinyls / Q000009:adverse effects*; D059230:Reflex, Trigeminocardiac / Q000187:drug effects*
chemical_list: C450660:Onyx copolymer; D011145:Polyvinyls; D001285:Atropine; D004121:Dimethyl Sulfoxide