title: Can Oxidative Stress Parameters Be Used as Biomarkers for the Discrimination of Malignant Head and Neck Tumors.
abstract: OBJECTIVE
  In this study the authors have investigated oxidative stress parameters in sera and tissues, and evaluated their significance for the differentiation of malignant and benign tumors.
  
  
  METHODS
  The study included 104 patients who were operated for head and neck tumors, and 45 healthy volunteers. Group 1 (n = 56) consisted of patients with malignant, Group 2 (n = 48) consisted of patients with benign tumors, and Group 3 (n = 45) was the control group. While both tissue and plasma samples were collected from groups 1 and 2, only plasma samples were collected from Group 3. Plasma and tissue levels of oxidative status were determined by using an automated measurement method.
  
  
  RESULTS
  Serum analysis revealed that total oxidant status (TOS) and oxidative stress index (OSI) values of Group 1 were significantly higher than those of Groups 2 and 3, and total antioxidant status (TAS) values of Group 1 were significantly lower than those of Groups 2 and 3. TAS values of Group 2 were lower than those of Group 3, but the difference was not statistically significant. Biochemical tissue analysis revealed that TOS and OSI values of Group 1 were significantly higher than those of Group 2, while TAS values of Group 1 were significantly lower than those of Group 2.
  
  
  CONCLUSIONS
  There is a significant difference between the total oxidative stress parameters of malignant and benign head and neck tumors. The authors think that total oxidative stress parameters can be used as a practical, cheap, and easy method for discriminating malignant tumors from benign tumors.
authors.affiliation: *Department of Otorhinolaryngology †Department of Biochemistry, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
authors.forename: Remzi
authors.initials: R
authors.lastname: Dogan
authors.forename: Ayşenur
authors.initials: A
authors.lastname: Meriç Hafiz
authors.forename: Selahattin
authors.initials: S
authors.lastname: Tugrul
authors.forename: Orhan
authors.initials: O
authors.lastname: Ozturan
authors.forename: Siddika
authors.initials: S
authors.lastname: Keskin
authors.forename: Abdurrahim
authors.initials: A
authors.lastname: Kocyigit
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010039:Otorhinolaryngologic Neoplasms / Q000175:diagnosis*; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants