title: Extracellular Matrices (ECM) for Tissue Repair.
abstract: Persistence of skin wounds due to underlying disease, bacterial contamination, and/or repeated trauma, causes a chronic condition where a functional extracellular matrix (ECM) cannot be established and the normal wound-healing cascade is unable to progress. These open chronic wounds leave the body susceptible to infection and present a major healthcare problem. To this end, a broad range of biologic ECM scaffolds have been developed that can provide other therapeutic options aside from traditional wound care approaches. These tissue engineered ECM scaffolds aim to facilitate the restoration of functional skin-like tissue by altering the chronic wound environment and facilitating cellular attachment, proliferation, and differentiation. This discussion will center on reviewing current ECM scaffolds and highlighting their properties and mechanism of action with respect to the clinical application in chronic, non-healing wounds.
authors.affiliation: Mount Sinai St. Luke's-West Hospitals, New York, NY.
authors.forename: Thais O
authors.initials: TO
authors.lastname: Polanco
authors.affiliation: Regenerative Orthopedics & Tissue Technologies, Integra LifeSciences, Plainsboro, NJ.
authors.forename: Joanna
authors.initials: J
authors.lastname: Xylas
authors.affiliation: Endovascular Surgery, Mount Sinai St. Luke's-West Hospitals, New York, NY.
authors.forename: John C
authors.initials: JC
authors.lastname: Lantis
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D005109:Extracellular Matrix / Q000637:transplantation*; D006801:Humans; D022125:Lacerations / Q000503:physiopathology* / Q000628:therapy*; D012867:Skin / Q000293:injuries* / Q000503:physiopathology*; D017768:Skin, Artificial; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology