title: Nanoscale Mo- MoO3 Entrapped in Engineering Thermoplastic: Inorganic Pathway to Bactericidal and Fungicidal Action.
abstract: In our contemporary endeavor, metallic molybdenum (Mo) and semiconducting molybdenum trioxide (MoO3) nanostructures have been simultaneously generated via solid state reaction between molybdenum (III) chloride (MoCl3) and polyphenylene sulfide (PPS) at 285 (°)C in unimolar ratio for different time durations, namely, 6 h, 24 h, and 48 h. The resultant nanocomposites (NCs) revealed formation of predominantly metallic Mo for all the samples. However, MoO3 gradually gained prominent position as secondary phase with rise in reaction time. The present study was intended to investigate the antibacterial potential of metal-metal oxide-polymer NCs, i.e., Mo- MoO3-PPS against microorganisms, viz., Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Aspergillus fumigatus. The antibacterial activity of the NCs was evaluated by agar well diffusion investigation. Maximum sensitivity concentrations of NCs were determined by finding out minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC). Moreover, the NCs prepared at reaction time of 48 h exhibited best MBC values and were tested with time kill assay which revealed that the growth of S. aureus was substantially inhibited by Mo- MoO3-PPS NCs. This synchronized formation of Mo- MoO3 nanostructures in an engineering thermoplastic may have potential antimicrobial applications in biomedical devices and components. Prima facie results on antifungal activity are indicative of the fact that these materials can show anti-cancer behavior.
authors.forename: Nilam
authors.initials: N
authors.lastname: Qureshi
authors.forename: Ravindra
authors.initials: R
authors.lastname: Chaudhari
authors.forename: Pramod
authors.initials: P
authors.lastname: Mane
authors.forename: Manish
authors.initials: M
authors.lastname: Shinde
authors.forename: Sandesh
authors.initials: S
authors.lastname: Jadakar
authors.forename: Sunit
authors.initials: S
authors.lastname: Rane
authors.forename: Bharat
authors.initials: B
authors.lastname: Kale
authors.forename: Anand
authors.initials: A
authors.lastname: Bhalerao
authors.forename: Dinesh
authors.initials: D
authors.lastname: Amalnerkar
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D006358:Hot Temperature; D008826:Microbial Sensitivity Tests; D008982:Molybdenum / Q000737:chemistry / Q000494:pharmacology*; D053761:Nanocomposites / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry / Q000494:pharmacology*; D010969:Plastics / Q000737:chemistry / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010087:Oxides; D010969:Plastics; D011108:Polymers; C082290:molybdenum trioxide; D008982:Molybdenum; C041325:polyphenylene sulfide