title: Early effect of intra-arterial treatment in ischemic stroke on aphasia recovery in MR CLEAN.
abstract: OBJECTIVE
  To investigate the effect of intra-arterial treatment (IAT) on early recovery from aphasia in acute ischemic stroke. We hypothesized that the early effect of IAT on aphasia is smaller than the effect on motor deficits.
  
  
  METHODS
  We included patients with aphasia from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN), in which 500 patients with a proximal anterior circulation stroke were randomized to usual care plus IAT (<6 hours after stroke, mainly stent retrievers) or usual care alone. We estimated the effect of IAT on the shift on the NIH Stroke Scale (NIHSS) item language and the NIHSS item motor arm at 24 hours and 1 week after stroke with multivariable ordinal logistic regression as a common odds ratio, adjusted for prognostic variables (acOR). Differences between the effect of IAT on aphasia and on motor deficits were tested in a multilevel model with a multiplicative interaction term.
  
  
  RESULTS
  Of the 288 patients with aphasia, 126 were assigned to IAT and 162 to usual care alone. The acOR for improvement of language score at 24 hours was 1.65 (95% confidence interval [CI] 1.05-2.60), and at 1 week 1.86 (95% CI 1.18-2.94). The acOR for improvement of motor deficit at 24 hours was 2.44 (95% CI 1.54-3.88), and at 1 week 2.32 (95% CI 1.43-3.77). The effect of IAT on language deficits was significantly different from the effect on motor deficits at 24 hours and 1 week (p = 0.005 and p = 0.011).
  
  
  CONCLUSIONS
  IAT results in better early recovery from aphasia than usual care alone. The early effect of IAT on aphasia is smaller than the effect on motor deficits.
  
  
  METHODS
  This study provides Class II evidence that for patients with acute ischemic stroke IAT increases early recovery from aphasia and that the early effect on aphasia, as measured by the NIHSS, is smaller than the effect on motor deficits.
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Yvette S
authors.initials: YS
authors.lastname: Crijnen
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Femke
authors.initials: F
authors.lastname: Nouwens
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Lonneke M L
authors.initials: LM
authors.lastname: de Lau
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Evy G
authors.initials: EG
authors.lastname: Visch-Brink
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Mieke W M E
authors.initials: MW
authors.lastname: van de Sandt-Koenderman
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Olvert A
authors.initials: OA
authors.lastname: Berkhemer
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Puck S S
authors.initials: PS
authors.lastname: Fransen
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Debbie
authors.initials: D
authors.lastname: Beumer
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Lucie A
authors.initials: LA
authors.lastname: van den Berg
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Hester F
authors.initials: HF
authors.lastname: Lingsma
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Yvo B W E M
authors.initials: YB
authors.lastname: Roos
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Aad
authors.initials: A
authors.lastname: van der Lugt
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: van Oostenbrugge
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Wim H
authors.initials: WH
authors.lastname: van Zwam
authors.affiliation: From the Departments of Neurology (Y.S.C., F.N., L.M.L.d.L., E.G.V.-B., O.A.B., P.S.S.F., D.B., D.W.J.D.), Rehabilitation Medicine (M.W.M.E.v.d.S.-K.), Radiology (P.S.S.F., A.v.d.L.), and Public Health (H.F.L.), Erasmus MC University Medical Center, Rotterdam; Department of Neurology (L.M.L.d.L.), Slotervaart Medical Center, Amsterdam; Rijndam Rehabilitation Institute (M.W.M.E.v.d.S.-K.), Rotterdam; Departments of Radiology (O.A.B., C.B.L.M.M.) and Neurology (L.A.v.d.B., Y.B.W.E.M.R.), Academic Medical Center, Amsterdam; and Departments of Neurology (D.B., R.J.v.O.) and Radiology (W.H.v.Z.), Maastricht University Medical Center, the Netherlands.
authors.forename: Charles B L M
authors.initials: CB
authors.lastname: Majoie
authors.forename: Diederik W J
authors.initials: DW
authors.lastname: Dippel
mesh_terms: D000368:Aged; D001037:Aphasia / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D001132:Arm / Q000503:physiopathology; D002545:Brain Ischemia / Q000150:complications* / Q000503:physiopathology / Q000601:surgery*; D057510:Endovascular Procedures; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D009426:Netherlands; D020127:Recovery of Function; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications* / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome