title: Identification of a germline F692L drug resistance variant in cis with Flt3-internal tandem duplication in knock-in mice.
authors.affiliation: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK od2@sanger.ac.uk gsv20@sanger.ac.uk.
authors.forename: Oliver M
authors.initials: OM
authors.lastname: Dovey
authors.affiliation: Department of Medical Genetics, School of Basic Medicine, Peking Union Medical College, Beijing, China State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China Department of Haematology, Cambridge University Hospitals NHS Trust, UK.
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.affiliation: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Mupo
authors.affiliation: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
authors.forename: Mathias
authors.initials: M
authors.lastname: Friedrich
authors.affiliation: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Australia PathWest Division of Clinical Pathology, Queen Elizabeth II Medical Centre, Nedlands, Australia.
authors.forename: Carolyn S
authors.initials: CS
authors.lastname: Grove
authors.affiliation: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Cooper
authors.affiliation: Takeda Pharmaceuticals International, Cambridge, MA, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Lee
authors.affiliation: Instituto de Biomedicina y Biotecnología de Cantabria, Santander, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Varela
authors.affiliation: Department of Medical Genetics, School of Basic Medicine, Peking Union Medical College, Beijing, China State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Huang
authors.affiliation: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK Department of Haematology, Cambridge University Hospitals NHS Trust, UK od2@sanger.ac.uk gsv20@sanger.ac.uk.
authors.forename: George S
authors.initials: GS
authors.lastname: Vassiliou
mesh_terms: D000818:Animals; D052160:Benzothiazoles / Q000494:pharmacology; D004351:Drug Resistance / Q000235:genetics*; D055879:Gene Knock-In Techniques; D018095:Germ-Line Mutation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics*; D051379:Mice; D009536:Niacinamide / Q000031:analogs & derivatives / Q000494:pharmacology; D010671:Phenylurea Compounds / Q000494:pharmacology; D000077157:Sorafenib; D020080:Tandem Repeat Sequences / Q000235:genetics; D014407:Tumor Cells, Cultured; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
chemical_list: D052160:Benzothiazoles; D010671:Phenylurea Compounds; D009536:Niacinamide; C544967:quizartinib; D000077157:Sorafenib; D051941:fms-Like Tyrosine Kinase 3
keywords: acute myeloid leukemia; molecular pharmacology; tyrosine kinase inhibitor resistance