title: G Protein-Coupled Receptor Signaling in Stem Cells and Cancer.
abstract: G protein-coupled receptors (GPCRs) are a large superfamily of cell-surface signaling proteins that bind extracellular ligands and transduce signals into cells via heterotrimeric G proteins. GPCRs are highly tractable drug targets. Aberrant expression of GPCRs and G proteins has been observed in various cancers and their importance in cancer stem cells has begun to be appreciated. We have recently reported essential roles for G protein-coupled receptor 84 (GPR84) and G protein subunit Gαq in the maintenance of cancer stem cells in acute myeloid leukemia. This review will discuss how GPCRs and G proteins regulate stem cells with a focus on cancer stem cells, as well as their implications for the development of novel targeted cancer therapies.
authors.affiliation: Cancer and Stem Cell Biology Group, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW 2052, Australia. JLynch@ccia.org.au.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Lynch
authors.affiliation: Cancer and Stem Cell Biology Group, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW 2052, Australia. jenny.wang@unsw.edu.au.|Centre for Childhood Cancer Research, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia. jenny.wang@unsw.edu.au.
authors.forename: Jenny Yingzi
authors.initials: JY
authors.lastname: Wang
mesh_terms: D000818:Animals; D006801:Humans; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D043562:Receptors, G-Protein-Coupled
keywords: G proteins; GPCR; cancer stem cells; signaling; stem cells; therapy