title: Safety evaluation and antihyperlipidemia effect of aqueous extracts from fermented puerh tea.
abstract: Fermented puerh tea, having undergone a long period of secondary oxidization and fermentation, has become more and more popular in recent years. In the present paper, a safety evaluation of aqueous extracts from fermented puerh tea (EFPT) was performed, including an oral acute toxicity study in rats and mice, mutation tests, a mouse micronucleus test, mouse sperm abnormality test and a 30 day feeding study in rats. Meanwhile, the antihyperlipidemia effect of EFPT was investigated as well. It was found that the oral maximum tolerated dose of EFPT was more than 10.0 g per kg body weight both in rats and mice. And it had no mutagenicity as judged by negative experimental results of the mutation test. No abnormal symptoms, clinical signs or deaths have been found in rats in each group throughout the experiments. In addition, EFPT in this study showed certain effects on hyperlipidemia.
authors.affiliation: Department of Tea Science, Zhejiang University, Hangzhou 310058, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
authors.forename: Le
authors.initials: L
authors.lastname: Ying
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.forename: Dedong
authors.initials: D
authors.lastname: Kong
authors.forename: Yuefei
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D000074421:Fermented Foods / Q000032:analysis*; D059022:Food Safety; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects; D064209:Phytochemicals / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013094:Spermatozoa / Q000187:drug effects / Q000378:metabolism; D013662:Tea / Q000737:chemistry*; D023382:Toxicity Tests, Acute; D014280:Triglycerides / Q000097:blood
chemical_list: D000960:Hypolipidemic Agents; D064209:Phytochemicals; D013662:Tea; D014280:Triglycerides; D002784:Cholesterol