title: [Extemporaneous withdrawal with a mini-spike filter: A low infection risk technique for drawing up bevacizumab for intravitreal injection].
abstract: OBJECTIVE
  To describe a technique for extemporaneously drawing up bevacizumab for intravitreal injection (IVT) and report the rate of post-injection endophthtalmitis.
  
  
  METHODS
  Retrospective monocentric analysis (January 2010-December 2014) of all IVT of bevacizumab drawn up with the following technique: in the operating room (class ISO 7) through a mini-spike with an integrated bacteria retentive air filter. The surgeon was wearing sterile gloves and a mask. The assisting nurse wore a mask. The bevacizumab vial was discarded at the end of each session.
  
  
  RESULTS
  Six thousand two hundred and thirty-six bevacizumab injections were performed. One case of endophthalmitis was noted (0.016%). During the same period, 4 cases of endophthalmitis were found after IVT of other drugs (4/32,992; 0.012%. P=0.8).
  
  
  CONCLUSIONS
  Intravitreal injection of bevacizumab after extemporaneous withdrawal through a mini-spike filter is a simple and safe technique. The risk of postoperative endophthalmitis is very low. This simple technique facilitates access to compounded bevacizumab.
authors.affiliation: Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France. Electronic address: jflerouic@gmail.com.
authors.forename: J F
authors.initials: JF
authors.lastname: Le Rouic
authors.affiliation: Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France.
authors.forename: D
authors.initials: D
authors.lastname: Breger
authors.affiliation: Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France.
authors.forename: P
authors.initials: P
authors.lastname: Peronnet
authors.affiliation: Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France.
authors.forename: E
authors.initials: E
authors.lastname: Hermouet-Leclair
authors.affiliation: Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France.
authors.forename: A
authors.initials: A
authors.lastname: Alphandari
authors.affiliation: Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France.
authors.forename: C
authors.initials: C
authors.lastname: Pousset-Decré
authors.affiliation: Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France.
authors.forename: I
authors.initials: I
authors.lastname: Badat
authors.affiliation: Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France.
authors.forename: F
authors.initials: F
authors.lastname: Becquet
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D000068258:Bevacizumab / Q000008:administration & dosage* / Q000009:adverse effects; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods; D004340:Drug Contamination / Q000517:prevention & control* / Q000706:statistics & numerical data; D009877:Endophthalmitis / Q000453:epidemiology / Q000517:prevention & control; D015818:Eye Infections, Bacterial / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D058449:Intravitreal Injections / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D008268:Macular Degeneration / Q000188:drug therapy*; D008851:Micropore Filters; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control; D012189:Retrospective Studies; D040242:Risk Reduction Behavior
chemical_list: D020533:Angiogenesis Inhibitors; D000068258:Bevacizumab
keywords: Age-related macular degeneration; Bevacizumab; Bévacizumab; Drawing up; Déconditionnement; Dégénérescence maculaire liée à l’âge; Endophtalmie; Endophthalmitis; Injection intravitréenne; Intravitreal injection