title: Ivy leaves dry extract EA 575® decreases LPS-induced IL-6 release from murine macrophages.
abstract: IL-6 plays a key role in the course of inflammatory processes as well as in the regulation of immune responses by the release of different cytokines. IL-6 is produced e.g. by macrophages recruited to the airways in response to a variety of inflammatory stimuli like allergens and respiratory viruses. Patients with inflammatory airway diseases therefore may benefit from therapies targeting the IL-6 pathway, e.g. reduction of the IL-6 release. Within this context, we tested the influence of the ivy leaves dry extract EA 575® on the LPS-induced release of IL-6 from murine macrophages (J774.2). One point seven µg/ml (5 µM) corticosterone served as positive control and was able to reduce LPS-induced IL-6 release by 46 ± 4%. EA 575® was tested in concentrations between 40 and 400 µg/ml. EA 575® decreased the LPS-induced IL-6 release in a dose-dependent manner and statistically significant by 25 ± 4%, 32 ± 4%, and 40 ± 7% in concentrations of 80, 160, and 400 µg/ml, respectively. The present data suggest an anti-inflammatory effect of EA 575® used in therapy of chronic- and acute inflammatory airway diseases accompanied with cough.
authors.forename: J
authors.initials: J
authors.lastname: Schulte-Michels
authors.forename: F
authors.initials: F
authors.lastname: Runkel
authors.forename: S
authors.initials: S
authors.lastname: Gokorsch
authors.forename: H
authors.initials: H
authors.lastname: Häberlein
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D003345:Corticosterone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D035981:Hedera / Q000737:chemistry*; D015850:Interleukin-6 / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; C000608183:EA 575 extract; D015850:Interleukin-6; D008070:Lipopolysaccharides; D010936:Plant Extracts; C577686:interleukin-6, mouse; D003345:Corticosterone