title: Immune reconstitution inflammatory syndrome, human herpesvirus 8 viremia, and HIV-associated multicentric Castleman disease.
abstract: Kaposi's sarcoma and multicentric Castleman Disease are HIV-related disease processes that are associated with human herpesvirus 8 (HHV-8) infection. The development of multicentric Castleman disease can often be a manifestation of the immune reconstitution inflammatory syndrome phenomenon and is associated with markedly elevated levels of HHV-8 viremia, as illustrated by this case.
authors.affiliation: Division of Infectious Diseases, George Washington University School of Medicine and Health Sciences, 150 Pennsylvania Avenue, NW, Washington, DC 20037, USA. Electronic address: msiegel@mfa.gwu.edu.
authors.forename: Marc O
authors.initials: MO
authors.lastname: Siegel
authors.affiliation: George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
authors.forename: Sanaz
authors.initials: S
authors.lastname: Ghafouri
authors.affiliation: Whitman Walker Health, Washington, DC, USA.
authors.forename: Ravi
authors.initials: R
authors.lastname: Ajmera
authors.affiliation: Division of Infectious Diseases, George Washington University School of Medicine and Health Sciences, 150 Pennsylvania Avenue, NW, Washington, DC 20037, USA.
authors.forename: Gary L
authors.initials: GL
authors.lastname: Simon
mesh_terms: D000328:Adult; D005871:Castleman Disease / Q000209:etiology* / Q000276:immunology; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D015497:HIV-1 / Q000502:physiology; D006566:Herpesviridae Infections / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000209:etiology* / Q000276:immunology / Q000821:virology; D008297:Male; D012514:Sarcoma, Kaposi / Q000150:complications; D014766:Viremia / Q000209:etiology / Q000276:immunology / Q000821:virology*
keywords: Human herpesvirus-8; Human immunodeficiency virus; Immune reconstitution inflammatory syndrome; Multicentric Castleman's disease