title: Near-Infrared Upconversion Chemodosimeter for In Vivo Detection of Cu(2+) in Wilson Disease.
abstract: Near-infrared upconversion chemodosimetry is a promising detection method by virtue of the frequency upconversion technique, which shows very high sensitivity and selectivity for the detection of Cu(2+) ions in vitro and in vivo. This method offers a new opportunity for noninvasive diagnosis of Wilson disease associated with Cu(2+) detection in clinical medicine.
authors.affiliation: Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers Institute of Biomedicine Sciences and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers Institute of Biomedicine Sciences and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Su
authors.affiliation: Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers Institute of Biomedicine Sciences and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, 200040, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers Institute of Biomedicine Sciences and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Yibing
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers Institute of Biomedicine Sciences and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Feng
authors.affiliation: Department of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, 200040, P. R. China.
authors.forename: Zhi-Ying
authors.initials: ZY
authors.lastname: Wu
authors.affiliation: Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers Institute of Biomedicine Sciences and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China.
authors.forename: Fuyou
authors.initials: F
authors.lastname: Li
mesh_terms: D002413:Cations, Divalent / Q000032:analysis; D003300:Copper / Q000032:analysis*; D006527:Hepatolenticular Degeneration / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans
chemical_list: D002413:Cations, Divalent; D003300:Copper
keywords: Wilson disease; copper-ion detection; frequency upconversion; in vivo detection