title: Potential Signaling Pathways Involved in the Clinical Application of Oxymatrine.
abstract: Oxymatrine, an alkaloid component extracted from the roots of Sophora species, has been shown to have antiinflammatory, antifibrosis, and antitumor effects and the ability to protect against myocardial damage, etc. The potential signaling pathways involved in the clinical application of oxymatrine might include the TGF-β/Smad, toll-like receptor 4/nuclear factor kappa-light-chain-enhancer of activated B cells, toll-like receptor9/TRAF6, Janus kinase/signal transduction and activator of transcription, phosphatidylinositol-3 kinase/Akt, delta-opioid receptor-arrestinl-Bcl-2, CD40, epidermal growth factor receptor, nuclear factor erythroid-2-related factor 2/heme oxygenase-1 signaling pathways, and dimethylarginine dimethylaminohydrolase/asymmetric dimethylarginine metabolism pathway. In this review, we summarize the recent investigations of the signaling pathways related to oxymatrine to provide clues and references for further studies on its clinical application. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital, Logistics University of People's Armed Police Force, Tianjin, 300162, China.
authors.forename: Mei-Li
authors.initials: ML
authors.lastname: Lu
authors.affiliation: Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital, Logistics University of People's Armed Police Force, Tianjin, 300162, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Xiang
authors.affiliation: Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital, Logistics University of People's Armed Police Force, Tianjin, 300162, China.
authors.forename: Shi-Hai
authors.initials: SH
authors.lastname: Xia
mesh_terms: D000470:Alkaloids / Q000494:pharmacology / Q000627:therapeutic use*; D001120:Arginine / Q000031:analogs & derivatives / Q000502:physiology; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D011807:Quinolizines / Q000494:pharmacology / Q000627:therapeutic use*; D050791:STAT Transcription Factors / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects*; D029909:Sophora / Q000737:chemistry*; D051193:Toll-Like Receptors / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D000093842:Matrines
chemical_list: D000470:Alkaloids; D001120:Arginine; D019869:Phosphatidylinositol 3-Kinases; D019253:Proto-Oncogene Proteins c-bcl-2; D011807:Quinolizines; D050791:STAT Transcription Factors; D051193:Toll-Like Receptors; D016212:Transforming Growth Factor beta; C018524:N,N-dimethylarginine; C037573:oxymatrine; D000093842:Matrines
keywords: clinical application; oxymatrine; signaling pathway