title: Association of COL1A1 polymorphism with high myopia: a Meta-analysis.
abstract: OBJECTIVE
  To investigate the association between collagen type I alpha 1 (COL1A1) gene and high myopia.
  
  
  METHODS
  In this Meta-analysis, we examined 5 published case-control studies that involved 1942 high myopia cases and 2929 healthy controls to assess the association between the COL1A1 rs2075555 polymorphism and high myopia risk. We calculated the pooled odds ratios (ORs) of COL1A1 rs2075555 polymorphism in high myopia cases vs healthy controls to evaluate the strength of the association.
  
  
  RESULTS
  Overall, there was no significant difference both in the genotype and allele distributions of COL1A1 rs2075555 polymorphism between high myopia cases and healthy controls: CC vs AA OR=1.10, 95% confidence interval (CI)=0.76-1.58; AC vs AA OR=0.98, 95%CI 0.80-1.20; CC/AC vs AA/OR=1.01, 95%CI 0.84-1.22; CC vs AC/AA OR=1.06, 95%CI=0.93-1.20; C vs A OR=1.06, 95%CI 0.91-1.23). In addition, in the stratified analyses by ethnicity, no significant associations were found in any genetic model both in European and Asia cohorts.
  
  
  CONCLUSIONS
  Our results indicate that the COL1A1 rs2075555 polymorphism may not affect susceptibility to high myopia.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China.
authors.forename: Guang-Ming
authors.initials: GM
authors.lastname: Jin
authors.affiliation: Department of Ophthalmology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong Province, China.
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Zhao
authors.affiliation: Department of Pharmacy, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong Province, China.
authors.forename: Ai-Ming
authors.initials: AM
authors.lastname: Chen
authors.affiliation: Department of Otorhinolaryngology, Jiangmen Central Hospital, Jiangmen 529030, Guangdong Province, China.
authors.forename: Yong-Xing
authors.initials: YX
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong Province, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
keywords: Meta-analysis; collagen type I alpha 1; high myopia; polymorphism