title: The role of mean platelet volume and platelet distribution width in the prediction of placental abruption.
abstract: We determined the role of mean platelet volume (MPV) and platelet distribution width (PDW) in the prediction of placental abruption (PA) prior to caesarean section. Data obtained between January 2011 and July 2014 from patients (n = 33) with PA and healthy control subjects (n = 67) matched for age- and gestation-stage were analysed. Pre-operative and post-operative MPV and PDW were significantly different between the PA and control groups when cut-off values for MPV were set at 9.23; sensitivity at 87.8% and specificity at 46.2%; positive predictive value (PPV) at 48.3%; and negative predictive value (NPV) at 90.0%. When the cut-off value for PDW was set at 18.5, the sensitivity was 100% and specificity 71.6%, PPV 40.7% and NPV 59.3% for the prediction of PA. MPV and PDW levels were significantly higher in cases of PA. These results suggest that clinical evaluation of MPV and PDW displays reasonable sensitivity and specificity as a marker of PA, prompting the need for more research in this area of clinical study.
authors.affiliation: a Department of Obstetrics and Gynaecology , Adana Numune Training and Research Hospital , Adana , Turkey.
authors.forename: Sefa
authors.initials: S
authors.lastname: Arlier
authors.affiliation: a Department of Obstetrics and Gynaecology , Adana Numune Training and Research Hospital , Adana , Turkey.
authors.forename: Cevdet
authors.initials: C
authors.lastname: Adiguzel
authors.affiliation: a Department of Obstetrics and Gynaecology , Adana Numune Training and Research Hospital , Adana , Turkey.
authors.forename: Esra Saygili
authors.initials: ES
authors.lastname: Yilmaz
authors.affiliation: a Department of Obstetrics and Gynaecology , Adana Numune Training and Research Hospital , Adana , Turkey.
authors.forename: Sevtap
authors.initials: S
authors.lastname: Seyfettinoglu
authors.affiliation: b Department of Obstetrics and Gynaecology , Bakirkoy Training and Research Hospital , Istanbul , Turkey.
authors.forename: Caglar
authors.initials: C
authors.lastname: Helvacioglu
authors.affiliation: c Health Ministry , Istanbul , Turkey.
authors.forename: Gulden Uzer
authors.initials: GU
authors.lastname: Ekin
authors.affiliation: a Department of Obstetrics and Gynaecology , Adana Numune Training and Research Hospital , Adana , Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Nazik
authors.affiliation: a Department of Obstetrics and Gynaecology , Adana Numune Training and Research Hospital , Adana , Turkey.
authors.forename: Oguz
authors.initials: O
authors.lastname: Yucel
mesh_terms: D000037:Abruptio Placentae / Q000097:blood / Q000175:diagnosis / Q000601:surgery; D001792:Blood Platelets / Q000473:pathology*; D002585:Cesarean Section / Q000379:methods; D005260:Female; D005865:Gestational Age; D006801:Humans; D063847:Mean Platelet Volume / Q000379:methods*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D012680:Sensitivity and Specificity; D014421:Turkey
keywords: Mean platelet volume; platelet distribution width; prediction of placental abruption; pregnancy