title: Association Between Apolipoprotein B XbaI Polymorphism and Coronary Heart Disease in Han Chinese Population: A Meta-Analysis.
abstract: OBJECTIVE
  To examine the association between apolipoprotein B (ApoB) XbaI polymorphisms (rs693) and coronary heart disease (CHD) risk among the Han Chinese population by systematically analyzing multiple independent studies.
  
  
  METHODS
  The Hardy-Weinberg equilibrium test was applied to check genetic equilibrium among genotypes for the selected literatures. The quality of the studies was assessed by using the NewcastleOttawa Scale. Power analysis was performed with Power and Precision V4 software. A fixed or random effect model was used on the basis of heterogeneity. Publication bias was quantified and examined with Begg's funnel plot test and Egger's linear regression test. The meta-analysis was performed by Stata 12.0 software.
  
  
  RESULTS
  A total of 10 eligible association studies were included in this meta-analysis, and the pooled sample consisted of 1195 CHD patients and 1178 health controls. No consistent inference regarding publication bias for the included studies was obtained by using the two above-mentioned methods. The pooled odds ratios (95% confidence intervals [CIs]) for X(-) versus X(+) allele and X(+)X(+) + X(+)X(-) versus X(-)X(-) genotype were 2.25 (1.40-3.62) and 2.21 (1.39-3.50), respectively.
  
  
  CONCLUSIONS
  This meta-analysis indicated that ApoB XbaI allele confers a significant risk towards the development of CHD among the Han Chinese population.
authors.affiliation: 1 Institute of Medical Systems Biology, and School of Public Health, Guangdong Medical University , Dongguan, P.R. China .
authors.forename: Yeda
authors.initials: Y
authors.lastname: Chen
authors.affiliation: 1 Institute of Medical Systems Biology, and School of Public Health, Guangdong Medical University , Dongguan, P.R. China .
authors.forename: Meihua
authors.initials: M
authors.lastname: Lin
authors.affiliation: 2 Maoming People's Hospital , Maoming, P.R. China .
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.affiliation: 2 Maoming People's Hospital , Maoming, P.R. China .
authors.forename: Naizun
authors.initials: N
authors.lastname: Zhang
authors.affiliation: 1 Institute of Medical Systems Biology, and School of Public Health, Guangdong Medical University , Dongguan, P.R. China .
authors.forename: Shaoqi
authors.initials: S
authors.lastname: Rao
mesh_terms: D001055:Apolipoproteins B / Q000235:genetics* / Q000378:metabolism; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D003327:Coronary Disease / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D001055:Apolipoproteins B