title: Morita-Baylis-Hillman Reaction of α,β-Unsaturated Ketones with Allylic Acetates by the Combination of Transition-Metal Catalysis and Organomediation.
abstract: An intermolecular Morita-Baylis-Hillman (MBH) reaction of α,β-unsaturated ketones with allylic acetates under the catalysis of 10 mol % of tetrakis(triphenylphosphine)palladium(0) and mediation of tributylphosphine has been developed in the presence of acetic acid, affording the desired α-coupling products. The MBH reaction has the advantages of good tolerance to many functional groups, excellent regioselectivity and E-stereoselectivity, and moderate to good yields.
authors.affiliation: Department of Chemistry, Zhejiang University , Hangzhou 310028, China.
authors.forename: Ya-Qiong
authors.initials: YQ
authors.lastname: Li
authors.affiliation: College of Pharmaceutical Sciences, Qiqihar Medical University , Qiqihar 161006, P. R. China.
authors.forename: Hai-Jun
authors.initials: HJ
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Zhejiang University , Hangzhou 310028, China.
authors.forename: Zhi-Zhen
authors.initials: ZZ
authors.lastname: Huang