title: Cartilage loss patterns within femorotibial contact regions during deep knee bend.
abstract: Osteoarthritis (OA) can alter knee kinematics and stresses. The relationship between cartilage loss in OA and kinematics is unclear, with existing work focusing on static wear and morphology. In this work, femorotibial cartilage maps were coupled with kinematics to investigate the relationship between kinematics and cartilage loss, allowing for more precise treatment and intervention. Cartilage thickness maps were created from healthy and OA subgroups (varus, valgus, and neutral) and mapped to a statistical bone atlas. Video fluoroscopy determined contact regions from 0° to 120° flexion. Varus and valgus subgroups displayed different wear patterns across the range of flexion, with varus knees showing more loss in early flexion and valgus in deeper flexion. For the femur, varus knees had more wear in the medial compartment than neutral or valgus and most wear at both 0° and 20° flexion. In the lateral femoral compartment, the valgus subgroup showed significantly more wear from 20° to 60° flexion as compared to other angles, though varus knees displayed highest magnitude of wear. For the tibia, most medial wear occurred at 0-40° flexion and most lateral occurred after 60° flexion. Knowing more about cartilage changes in OA knees provides insight as to expected wear or stresses on implanted components after arthroplasty. Combining cartilage loss patterns with kinematics allows for pre-surgical intervention and treatments tailored to the patient׳s alignment and kinematics. Reported wear patterns may also serve as a gauge for post-operative loading to be considered when placing implant components.
authors.affiliation: Department of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996, USA.
authors.forename: J
authors.initials: J
authors.lastname: Michael Johnson
authors.affiliation: Department of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996, USA. Electronic address: mmahfouz@utk.edu.
authors.forename: Mohamed R
authors.initials: MR
authors.lastname: Mahfouz
mesh_terms: D000368:Aged; D001696:Biomechanical Phenomena; D002356:Cartilage / Q000502:physiology*; D005260:Female; D005269:Femur / Q000502:physiology*; D006801:Humans; D007719:Knee Joint / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000503:physiopathology*; D016059:Range of Motion, Articular; D013977:Tibia / Q000502:physiology*
keywords: Cartilage degeneration; Kinematics; Knee cartilage; Osteoarthritis; Statistical modeling