title: MMP-9 genetic polymorphism may confer susceptibility to COPD.
abstract: Correlations between genetic polymorphisms of three matrix metalloproteinase (MMP) genes and susceptibility to chronic obstructive pulmonary disease (COPD) were investigated. Relevant case-control studies were selected using rigorous inclusion and exclusion criteria. The comprehensive Meta-analysis 2.0 software was used to conduct the statistical analysis. An odds ratio with 95% confidence intervals was applied to assess the correlation between genetic polymorphisms of MMPs and susceptibility to COPD. Twelve high-quality studies were selected for inclusion in this meta-analysis. These studies included a combined total of 1533 COPD patients and 1530 healthy controls. The result of the meta-analysis showed that MMP-9 rs3918242 C > T was significantly correlated with increased susceptibility to COPD. However, MMP-1 rs1799750 1G > 2G and MMP-3 rs3025058 5A > 6A were not associated with COPD risk (all P > 0.05). Based on our meta-analysis, MMP-9 rs3918242 C > T is correlated with susceptibility to COPD, but MMP-1 rs1799750 1G > 2G and MMP-3 rs3025058 5A > 6A are not. These results should be further confirmed using a larger sample size.
authors.affiliation: Second Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
authors.forename: S
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Second Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Yang
authors.affiliation: Second Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Chen
authors.affiliation: Second Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
authors.forename: Z
authors.initials: Z
authors.lastname: He
authors.affiliation: Second Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Second Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Second Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Second Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
authors.forename: M Q
authors.initials: MQ
authors.lastname: Tan
mesh_terms: D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics* / Q000473:pathology
chemical_list: D019278:Matrix Metalloproteinase 3; D020780:Matrix Metalloproteinase 9; D020781:Matrix Metalloproteinase 1