title: Molecular genetics of thyroid cancer.
abstract: The pathogenesis of the development and progression of thyroid cancer (TC) is far from being clear at present. Accumulated evidence suggests that it is a complex polygenic disorder for which genetic factors play an important role in disease aetiology. Here we review the literature to report the genetic variations and alterations that have been described in the aetiology of TC. The functional effects of some mutations and single nucleotide polymorphisms on TC are validated, establishing the role of sequence variations in this cancer. However, large prospective studies are still required to evaluate the diagnostic and prognostic value of these genetic determinants in clinical practice.
authors.affiliation: Laboratory of Molecular and Cellular Screening Processes,Centre of Biotechnology of Sfax,University of Sfax,Route Sidi Mansour,PO Box 1177,3018 Sfax,Tunisia.
authors.forename: Maha
authors.initials: M
authors.lastname: Rebaї
authors.affiliation: Laboratory of Molecular and Cellular Screening Processes,Centre of Biotechnology of Sfax,University of Sfax,Route Sidi Mansour,PO Box 1177,3018 Sfax,Tunisia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Rebaї
mesh_terms: D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology