title: Randomized clinical trial comparing ceftiofur hydrochloride with a positive control protocol for intramammary treatment of nonsevere clinical mastitis in dairy cows.
abstract: The objective of this study was to compare ceftiofur hydrochloride with a positive control protocol for intramammary treatment of nonsevere clinical mastitis in dairy cows. A total of 264 clinical mastitis cases on 11 commercial dairy farms were treated with intramammary infusions, once a day for 4 d using 1 of 2 treatments: (1) ceftiofur hydrochloride 125mg; or (2) control: tetracycline 200mg + neomycin 250mg + bacitracin 28mg + prednisolone 10mg. Streptococcus agalactiae was the most frequently isolated gram-positive pathogen from clinical mastitis, followed by Staphylococcus aureus. Klebsiella spp. and Escherichia coli were the most isolated gram-negative bacteria from clinical mastitis. No significant differences were observed between treatments regarding the overall clinical cure, bacteriological cure, and new infection. No effect of treatment regimen was observed when the bacterial group (gram-positive vs. gram-negative) was evaluated. The overall clinical cure was 0.79 for ceftiofur-treated cows and 0.74 for control-treated cows, whereas the overall bacteriological cure was 0.79 for ceftiofur-treated cows and 0.76 for control-treated cows. Furthermore, the new intramammary infection was 0.10 for cows treated with ceftiofur and 0.11 for cows treated with control. In conclusion, the use of intramammary ceftiofur hydrochloride for treatment of nonsevere clinical mastitis has similar efficacy as a treatment regimen with a combination of antimicrobial agents (tetracycline + neomycin + bacitracin).
authors.affiliation: Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, University of São Paulo, Pirassununga 13635-900, São Paulo, Brazil.
authors.forename: Cristina Simões
authors.initials: CS
authors.lastname: Cortinhas
authors.affiliation: Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, University of São Paulo, Pirassununga 13635-900, São Paulo, Brazil.
authors.forename: Tiago
authors.initials: T
authors.lastname: Tomazi
authors.affiliation: Department of Agricultural Sciences, Federal University of Paraná, Curitiba 80060-000, Paraná, Brazil.
authors.forename: Mário Sérgio Ferreira
authors.initials: MSF
authors.lastname: Zoni
authors.affiliation: Zoetis Animal Health, São Paulo 04709-111, São Paulo, Brazil.
authors.forename: Elio
authors.initials: E
authors.lastname: Moro
authors.affiliation: Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, University of São Paulo, Pirassununga 13635-900, São Paulo, Brazil. Electronic address: mveiga@usp.br.
authors.forename: Marcos
authors.initials: M
authors.lastname: Veiga Dos Santos
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002417:Cattle; D002511:Cephalosporins / Q000627:therapeutic use*; D005260:Female; D007709:Klebsiella; D008414:Mastitis, Bovine / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C053503:ceftiofur
keywords: ceftiofur hydrochloride; clinical and bacteriological cure; clinical mastitis therapy