title: Diabetes and the risk of biochemical recurrence in patients with treated localized prostate cancer: a meta-analysis.
abstract: BACKGROUND
  Biochemical recurrence (BCR), or an elevation in prostate-specific antigen in men after treatment for localized prostate cancer, is an early indication of clinical progression, distant metastases, and mortality. Correlations have also recently been established between diabetes and the incidence and mortality of prostate cancer. However, it remains unknown whether diabetes may predict BCR.
  
  
  METHODS
  We performed a meta-analysis of published articles to investigate the prognostic value of diabetes for BCR in prostate cancer. Eight studies and 11,923 patients were included in our meta-analysis. The relative risk (RR) and its 95 % confidence interval (CI) were calculated.
  
  
  RESULTS
  We found no apparent association between diabetes and BCR (adjusted RR 1.04; 95 % CI 0.87-1.22).
  
  
  CONCLUSIONS
  The evidence of this meta-analysis indicates that diabetes is not a predictor of risk of BCR in patients with prostate cancer.
authors.affiliation: Department of Oncology, Yijishan Hospital of Wannan Medical College, No. 2 West Zheshan Road, Wuhu, 241001, China.
authors.forename: Qingling
authors.initials: Q
authors.lastname: Hua
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Yanzhe
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Oncology, Yijishan Hospital of Wannan Medical College, No. 2 West Zheshan Road, Wuhu, 241001, China. yexiaobing2015@163.com.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Ye
mesh_terms: D003920:Diabetes Mellitus / Q000453:epidemiology*; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000453:epidemiology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology*
chemical_list: D017430:Prostate-Specific Antigen
keywords: Biochemical recurrence; Diabetes; Meta-analysis; Prostate cancer