title: Micronutrient Intake in the Etiology, Prevention and Treatment of Osteosarcopenic Obesity.
abstract: Aging, chronic inflammation and/or many chronic conditions may result in loss of bone, loss of muscle and increased adiposity, manifested either overtly (overweight) or furtively as fat infiltration into bone and muscle. This combined condition has been identified as osteosarcopenic obesity. Micronutrients are required, not just to prevent deficiency diseases, but for optimal health and metabolic homeostasis. Further, micronutrients have multifunctional roles in the body. However, it is unknown if the micronutrient intake of the Western diet contributes to bone and muscle loss, increased adiposity, and ultimately osteosarcopenic obesity.
  
  
  
  The aim of this review is to examine the micronutrient intake using US National Health and Nutrition Examination Survey (NHANES) data, and explore if the insufficiencies, or excesses present contribute to the development of osteosarcopenic obesity in aging.
  
  
  
  First NHANES food intake data from 2002-2012 were obtained and transposed to Microsoft Excel for analysis. A literature search of PubMed and Medline for human data using combinations and synonyms of osteoporosis, sarcopenia and obesity, and each mineral and vitamin indicated as insufficient by NHANES.
  
  
  
  NHANES data suggested phosphorus, calcium, magnesium, potassium, iron, and vitamins B6/B12/C/A/D/E and K were candidates for further evaluation. 170 articles were included.
  
  
  
  While chronic single/multiple micronutrient insufficiency/excess is not studied in clinical trials, NHANES data suggest that they have existed for at least a decade. Examining the status and roles of those nutrients may be important to understanding the health issues associated with Western-type diets, including development of osteosarcopenic obesity.
authors.affiliation: Abbott Nutrition, RP3-2, 3300 Stelzer Road, Columbus, Ohio 43219, USA.
authors.forename: Owen J
authors.initials: OJ
authors.lastname: Kelly
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Gilman
authors.forename: Youjin
authors.initials: Y
authors.lastname: Kim
authors.forename: Jasminka Z
authors.initials: JZ
authors.lastname: Ilich
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001851:Bone Diseases, Metabolic / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D066273:Diet, Western; D004435:Eating; D005260:Female; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000150:complications; D018977:Micronutrients / Q000008:administration & dosage*; D008875:Middle Aged; D008903:Minerals / Q000009:adverse effects; D009749:Nutrition Surveys; D009751:Nutritional Requirements; D009765:Obesity / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D055948:Sarcopenia / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D014481:United States; D055815:Young Adult
chemical_list: D018977:Micronutrients; D008903:Minerals