title: Study of serum uric acid and creatinine in hypertensive disorders of pregnancy.
abstract: BACKGROUND
  Renal dysfunction, increased xanthine oxidase activity and oxidative stress in placenta contributes to the elevated uric acid levels in preeclampsia (PE).
  
  
  OBJECTIVE
  To determine serum uric acid and creatinine in hypertensive disorders of pregnancy and correlate with fetal outcome.
  
  
  METHODS
  Pregnant women ≥32 weeks of gestation. Study population included 3 groups, 31 normotensive pregnant (NP) women as controls, 30 pregnant women with gestational hypertension (GH) and 30 with PE.
  
  
  RESULTS
  Serum uric acid and creatinine levels were significantly elevated in PE (6.26±1.19 and 0.94±0.26 mg/dL) when compared with Pregnancy induced hypertension (PIH) (4.27± 1.0 and 0.66 ±0.19 mg/dL) and NP (4.25 ± 0.8 and 0.63± 0.13 mg/dL) (P-value <0.001 and <0.001) respectively. Receiver operation characteristics curves demonstrated greater sensitivity and specificity for uric acid (86.7% and 83.9%, respectively) in PE than for creatinine (80% and 77.4%, respectively). Uric acid had strong and negative correlation with fetal birth weight in PE (r= -0.59,P= 0.006), where as creatinine had negative but weak correlation (r= -0.03,P=0.87).
  
  
  CONCLUSIONS
  Serum uric acid is a better diagnostic and predictive marker for PE and fetal outcome respectively.
authors.affiliation: Department of Biochemistry, MediCiti Institute of Medical Sciences, Ghanpur, Medchal Mandal Ranga, Reddy District, Telangana, India.
authors.forename: Sapna
authors.initials: S
authors.lastname: Vyakaranam
authors.affiliation: Department of Biochemistry, MediCiti Institute of Medical Sciences, Ghanpur, Medchal Mandal Ranga, Reddy District, Telangana, India.
authors.forename: Aparna Varma
authors.initials: AV
authors.lastname: Bhongir
authors.affiliation: Department of Biochemistry, MediCiti Institute of Medical Sciences, Ghanpur, Medchal Mandal Ranga, Reddy District, Telangana, India.
authors.forename: Dakshayani
authors.initials: D
authors.lastname: Patlolla
authors.affiliation: Department of Gynecology & Obstetrics, MediCiti Institute of Medical Sciences, Ghanpur, Medchal Mandal Ranga, Reddy District, Telangana, India.
authors.forename: Rekha
authors.initials: R
authors.lastname: Chintapally
keywords: Uric acid; creatinine; gestational hypertension; preeclampsia