title: Phytochemical, Antioxidant and Anticancer Activities of Extracts of Seven Fruits Found in the Southern Brazilian Flora.
abstract: Methanol extracts of seven edible fruits found in southern Brazil: Garcinia achachairu, Rubus imperialis, Rubus rosaefolius, Solanum quitoense, Solanum sessiliflorun, Diospyros inconstans and Plinia glomerata, were evaluated for their total phenol content and antioxidant activity in different in vitro free radical scavenging models. In addition, studies were performed on cell viability of extracts of the seeds of G. achachairu against murine melanoma cells. The fruits peel and seeds of G. achachairu were very promising in terms of total phenol content (data in gallic acid equivalent per gram), as assessed by the Folin-Ciocalteu method, with values of 9.70±3.2 and 8.40±1.1, respectively. On the other hand, antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl scavenging assay showed that the fruit pulp and peel of P. glomerata presented the best profile, with values of the 16.3±1.8 and 15.9±2.4 μg/ml, respectively. Regarding the cytotoxic effect of methanol extract and guttiferone A from G. achachairu, we have observed that both inhibit the growth of B16F10 tumor cells, with calculated IC50 values of 49.6±2.1 mg/ml and 48.6±5.4 mM, respectively.
authors.affiliation: Post-Graduate Program in Pharmaceutical Sciences, Center for Chemical-Pharmaceutical Research (NIQFAR), University of Vale do ItajaÍ-UNIVALI, ItajaÍ, Santa Catarina, Brazil.
authors.forename: P C D
authors.initials: PC
authors.lastname: Bagattoli
authors.affiliation: Post-Graduate Program in Pharmaceutical Sciences, Center for Chemical-Pharmaceutical Research (NIQFAR), University of Vale do ItajaÍ-UNIVALI, ItajaÍ, Santa Catarina, Brazil.
authors.forename: D C
authors.initials: DC
authors.lastname: Cipriani
authors.affiliation: Post-Graduate Program in Pharmaceutical Sciences, Center for Chemical-Pharmaceutical Research (NIQFAR), University of Vale do ItajaÍ-UNIVALI, ItajaÍ, Santa Catarina, Brazil.
authors.forename: L N B
authors.initials: LN
authors.lastname: Mariano
authors.affiliation: Post-Graduate Program in Pharmaceutical Sciences, Center for Chemical-Pharmaceutical Research (NIQFAR), University of Vale do ItajaÍ-UNIVALI, ItajaÍ, Santa Catarina, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Correa
authors.affiliation: Post-Graduate Program in Pharmaceutical Sciences, Center for Chemical-Pharmaceutical Research (NIQFAR), University of Vale do ItajaÍ-UNIVALI, ItajaÍ, Santa Catarina, Brazil.
authors.forename: T M
authors.initials: TM
authors.lastname: Wagner
authors.affiliation: Post-Graduate Program in Pharmaceutical Sciences, Center for Chemical-Pharmaceutical Research (NIQFAR), University of Vale do ItajaÍ-UNIVALI, ItajaÍ, Santa Catarina, Brazil.
authors.forename: V F
authors.initials: VF
authors.lastname: Noldin
authors.affiliation: Post-Graduate Program in Pharmaceutical Sciences, Center for Chemical-Pharmaceutical Research (NIQFAR), University of Vale do ItajaÍ-UNIVALI, ItajaÍ, Santa Catarina, Brazil.
authors.forename: V Cechinel
authors.initials: VC
authors.lastname: Filho
authors.affiliation: Post-Graduate Program in Pharmaceutical Sciences, Center for Chemical-Pharmaceutical Research (NIQFAR), University of Vale do ItajaÍ-UNIVALI, ItajaÍ, Santa Catarina, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Niero
keywords: Antioxidant; Brazilian fruits; Garcinia achachairu; cytotoxicity