title: The effect of ubiquinone on functional recovery and morphometric indices of sciatic nerve regeneration.
abstract: A common cause of peripheral nerve injury is trauma. The positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. In this experiment, the effect of intraperitoneal administration of ubiquinone (CoQ10) on an acute experimentally sciatic nerve crush was studied in a rat model. Forty-five male Wistar rats, weighing between 160-180 g were used. The rats were randomly divided into two experimental groups (n=20). Each group was further subdivided into four subgroups of five animals each. Functional studies confirmed the faster recovery of regenerated axons in the treatment group compared to the un-treated group (P<0.05). Morphometric indices of the regenerated fibers showed the number and diameter of the myelinated fibers to be significantly higher in the treatment group than the un-treated group (P<0.05). Intraperitoneal administration of CoQ10 (10 mg/kg/day) in the early inflammatory stage of sciatic nerve crush was found to improve nerve regeneration.
authors.affiliation: Graduated from Faculty of Veterinary Medicine, Urmia University, Urmia, Iran;
authors.forename: Z
authors.initials: Z
authors.lastname: Moradi
authors.affiliation: Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran;
authors.forename: S
authors.initials: S
authors.lastname: Azizi
authors.affiliation: Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Hobbenaghi
keywords: Crush; Peripheral nerve regeneration; Ubiquinone (coenzyme Q10)