title: Evaluation of oxidative stress and thyroid hormone status in hemodialysis patients in Gorgan.
abstract: OBJECTIVE
  The aim of this study focused on serum malondialdehyde (MDA) levels and erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities in hemodialysis patients and compared with control groups.
  
  
  METHODS
  Forty-five hemodialyzed patients and 45 control groups recruited in this study. Serum creatinine and urea, thyroid hormones (THs) levels and erythrocyte antioxidant enzyme activities were determined.
  
  
  RESULTS
  Hemodialysis (HD) patients showed higher levels of MDA than control groups (P < 0.01), but the levels of thyroxin (T3), free triiodothyronine (fT3), and free thyroxin (fT4), SOD and CAT were low in HD patients (P < 0.01). Serum T3, fT3, and fT4 levels were significantly negative correlated with MDA (P < 0.01).
  
  
  CONCLUSIONS
  It is concluded that serum lipid peroxidation is markedly increased in HD patients. This means that elevated reactive oxygen species may interact with the lipid molecules in HD patients. HD may cause significant changes in TH levels. Thyroid-stimulating hormone level in HD patients is slightly similar to that of control groups. This suggests that thyroid is able to resynthesize for hormonal urinary losses.
authors.affiliation: Student Research Committee, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Velayeti
authors.affiliation: Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran.
authors.forename: Azad Reza
authors.initials: AR
authors.lastname: Mansourian
authors.affiliation: Department of Internal Medicine, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mojerloo
authors.affiliation: Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran.
authors.forename: Abdoljalal
authors.initials: A
authors.lastname: Marjani
keywords: Antioxidant enzymes; hemodialysis; lipid peroxidation; thyroid hormones