title: Function and regulation of the Arp2/3 complex during cell migration in diverse environments.
abstract: As the first de novo actin nucleator discovered, the Arp2/3 complex has been a central player in models of protrusive force production via the dynamic actin network. Here, we review recent studies on the functional role of the Arp2/3 complex in the migration of diverse cell types in different migratory environments. These findings have revealed an unexpected level of plasticity, both in how cells rely on the Arp2/3 complex for migration and other physiological functions and in the intricate modulation of the Arp2/3 complex by other actin regulators and upstream signaling cascades.
authors.affiliation: Department of Cell Biology, Johns Hopkins University School of Medicine, 855 North Wolfe Street, 450 Rangos Building, Baltimore, MD 21205, USA; Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, 3400 North Charles Street, 100 Croft Hall, Baltimore, MD 21218, USA. Electronic address: kfranso1@jhmi.edu.
authors.forename: Kristen F
authors.initials: KF
authors.lastname: Swaney
authors.affiliation: Department of Cell Biology, Johns Hopkins University School of Medicine, 855 North Wolfe Street, 450 Rangos Building, Baltimore, MD 21205, USA; Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, 3400 North Charles Street, 100 Croft Hall, Baltimore, MD 21218, USA.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
mesh_terms: D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism*; D000199:Actins / Q000378:metabolism; D000818:Animals; D002465:Cell Movement; D006801:Humans; D008954:Models, Biological; D058105:Polymerization; D021122:Protein Subunits / Q000378:metabolism
chemical_list: D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D021122:Protein Subunits