title: Autism and cerebellar dysfunction: Evidence from animal models.
abstract: Autism is a prevalent neurodevelopmental disorder whose origins are not well understood. Cerebellar involvement has been implicated in the pathogenesis of autism spectrum disorders with increasing evidence from both clinical studies and animal models supporting an important role for cerebellar dysfunction in autism spectrum disorders. This article discusses the various cerebellar contributions to autism spectrum disorders. Both clinical and preclinical studies are discussed and future research directions highlighted.
authors.affiliation: University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: peter.tsai@utsouthwestern.edu.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Tsai
mesh_terms: D000818:Animals; D000067877:Autism Spectrum Disorder / Q000473:pathology* / Q000503:physiopathology; D002526:Cerebellar Diseases / Q000473:pathology* / Q000503:physiopathology; D002531:Cerebellum / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans
keywords: Animal models; Autism spectrum disorders; Cerebellum; Circuitry; Critical periods