title: Trachyspermum ammi 10 % topical cream versus placebo on neuropathic pain, a randomized, double-blind, placebo-controlled trial.
abstract: A four-week, double-blind, randomized, placebo-controlled trial was conducted to assay the effectiveness of Ajwain 10 % (Trachyspermum ammi Sprague) topical cream on neuropathic pain. Intervention encompassed Ajwain 10 % and placebo creams. Ninety-two patients who specifically mentioned daily and nocturnal burning feet were randomly assigned to receive one of those interventions. Presence and decline in patients' numbness, tingling and allodynia were also evaluated. Major outcome measure was alteration in feet burning intensity (final week versus baseline week) regarding to a visual analog scale on a 0-10 cm scale (0 being "no pain", 10 being "worst pain"). Significant reduction in feet burning scores as well as numbness, tingling and allodynia were found in Ajwain group compared to placebo. This trial examining a cream of Ajwain essential oil versus placebo revealed the significance difference between two groups. This medicament can be a good candidate for the alleviation of feet burning, a neuropathic complication.
authors.affiliation: Clinical Neurology Research Center, Neurology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Petramfar
authors.affiliation: Medicinal Plants Processing Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.|Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mahmoodreza
authors.initials: M
authors.lastname: Moein
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Soliman Mohammadi
authors.initials: SM
authors.lastname: Samani
authors.affiliation: Department of Epidemiology, School of Public Health, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Sayed Hamidreza
authors.initials: SH
authors.lastname: Tabatabaei
authors.affiliation: Medicinal Plants Processing Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran. zarm@sums.ac.ir.|Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. zarm@sums.ac.ir.
authors.forename: Mohammad M
authors.initials: MM
authors.lastname: Zarshenas
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D031165:Ammi / Q000737:chemistry*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000188:drug therapy*; D010147:Pain Measurement; D016896:Treatment Outcome
keywords: Clinical trial; Cream; Essential oil; Neuropathic pain; Placebo; Trachyspermum ammi