title: Association of the hypertriglyceridemic waist phenotype and type 2 diabetes mellitus among adults in China.
abstract: OBJECTIVE
  To clarify the association of the hypertriglyceridemic waist phenotype and type 2 diabetes mellitus among adults in China.
  
  
  METHODS
  In the present case-control study, we included 1,685 patients with type 2 diabetes mellitus and 7,141 normal glucose-tolerant controls from the Henan Province of China in 2011. Elevated waist circumference (GW) was defined as ≥90 cm for men and ≥80 cm for women. Hypertriglyceridemia (HT) was defined as >1.7 m mol/L triglycerides (TG) level. The association of hypertriglyceridemic waist phenotype and type 2 diabetes mellitus was investigated by sex, body mass index, physical activity, and family history of diabetes.
  
  
  RESULTS
  Cases and controls differed in age, waist circumference (WC), weight, TG level, fasting glucose, body mass index, smoking status, diabetic family history, physical activity and hypertriglyceridemic waist phenotype (P < 0.05), but not alcohol drinking (P = 0.63). In the overall sample, as compared with the phenotype of normal TG level and normal WC (NTNW), normal TG level/enlarged WC (NTGW), elevated TG level/normal WC (HTNW) and elevated TG level/enlarged WC (HTGW) were associated with type 2 diabetes mellitus (odds ratio 4.14, 2.42 and 6.23, respectively). Only HTGW was consistently associated with risk of type 2 diabetes mellitus, with or without adjustment. The strongest relationship between HTGW and type 2 diabetes mellitus was for subjects with body mass index <24.0 kg/m(2) (odds ratio 6.54, 95% confidence interval 4.22-10.14) after adjustment for cofounding variables.
  
  
  CONCLUSIONS
  HTGW was stably and significantly associated with risk of type 2 diabetes mellitus in adult Chinese.
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Preventive Medicine, Shenzhen University School of Medicine, Shenzhen, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, China.
authors.forename: Jingzhi
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
authors.forename: Chongjian
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Preventive Medicine, Shenzhen University School of Medicine, Shenzhen, China.
authors.forename: Xinping
authors.initials: X
authors.lastname: Luo
authors.affiliation: The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Jiatong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Clinical Medicine, Shenzhen University School of Medicine, Shenzhen, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Zhu
authors.affiliation: Department of Preventive Medicine, School of Public Health, Guiyang Medical University, Guiyang, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yin
authors.affiliation: Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Pang
authors.affiliation: Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, China.
authors.forename: Tianping
authors.initials: T
authors.lastname: Feng
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China.|Department of Preventive Medicine, Shenzhen University School of Medicine, Shenzhen, China.
authors.forename: Bingyuan
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China.|Department of Preventive Medicine, Shenzhen University School of Medicine, Shenzhen, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China.|Department of Preventive Medicine, Shenzhen University School of Medicine, Shenzhen, China.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China.|Department of Preventive Medicine, Shenzhen University School of Medicine, Shenzhen, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D064250:Hypertriglyceridemic Waist / Q000150:complications / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D055815:Young Adult
keywords: Adult; Hypertriglyceridemic waist phenotype; Type 2 diabetes mellitus