title: 14C BOMB-PULSE DATING AND STABLE ISOTOPE ANALYSIS FOR GROWTH RATE AND DIETARY INFORMATION IN BREAST CANCER?
abstract: The purpose of this study was to perform an initial investigation of the possibility to determine breast cancer growth rate with (14)C bomb-pulse dating. Tissues from 11 breast cancers, diagnosed in 1983, were retrieved from a regional biobank. The estimated average age of the majority of the samples overlapped the year of collection (1983) within 3σ Thus, this first study of tumour tissue has not yet demonstrated that (14)C bomb-pulse dating can obtain information on the growth of breast cancer. However, with further refinement, involving extraction of cell types and components, there is a possibility that fundamental knowledge of tumour biology might still be gained by the bomb-pulse technique. Additionally, δ (13)C and δ (15)N analyses were performed to obtain dietary and metabolic information, and to serve as a base for improvement of the age determination.
authors.affiliation: Department of Translational Medicine, Division of Diagnostic Radiology, Lund University, Malmö, Sweden kristina.lang@med.lu.se.
authors.forename: K
authors.initials: K
authors.lastname: Lång
authors.affiliation: Department of Physics, Division of Nuclear Physics, Lund University, Lund, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Eriksson Stenström
authors.affiliation: Epidemiology and Register Centre South, Skåne University Hospital, Lund, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Rosso
authors.affiliation: Department of Clinical Sciences, Division of Medical Radiation Physics, Lund University, Lund, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Bech
authors.affiliation: Department of Translational Medicine, Division of Diagnostic Radiology, Lund University, Malmö, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Zackrisson
authors.affiliation: Department of Clinical Sciences, Division of Pathology, Lund University, Lund, Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Graubau
authors.affiliation: Department of Translational Medicine, Division of Medical Radiation Physics, Lund University, Malmö, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Mattsson
mesh_terms: D018070:Biological Specimen Banks; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002138:Calibration; D002247:Carbon Isotopes / Q000737:chemistry; D002250:Carbon Radioisotopes / Q000737:chemistry*; D004032:Diet; D018450:Disease Progression; D005260:Female; D006801:Humans; D009584:Nitrogen; D009587:Nitrogen Isotopes / Q000737:chemistry; D010865:Pilot Projects; D055110:Radiometric Dating; D013997:Time Factors
chemical_list: D002247:Carbon Isotopes; D002250:Carbon Radioisotopes; D009587:Nitrogen Isotopes; D009584:Nitrogen