title: Iridium(iii)-catalyzed regioselective C7-sulfonamidation of indoles.
abstract: Iridium(iii)-catalyzed direct C7-sulfonamidation of indoles with sulfonyl azides is described. The developed method has good compatibility with diverse functional groups, providing various 7-amino-substituted indoles with good to excellent yields in a short time under mild reaction conditions. The key feature of the developed method is the regioselective functionalization at the C7-position of 2,3-unsubstituted indoles. Biologically active compounds can be obtained using this protocol. The application of the iridium(iii) catalyst and directing group plays a crucial role in the regioselectivity of the developed reaction.
authors.affiliation: Abteilung Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany. andrey.antonchick@mpi-dortmund.mpg.de.
authors.forename: Zengqiang
authors.initials: Z
authors.lastname: Song
authors.forename: Andrey P
authors.initials: AP
authors.lastname: Antonchick