title: 2-Aminophenyl-1H-pyrazole as a Removable Directing Group for Copper-Mediated C-H Amidation and Sulfonamidation.
abstract: 2-Aminophenyl-1H-pyrazole was discovered as a removable bidentate directing group for copper-mediated aerobic oxidative C(sp(2)-H) bond amidation and sulfonamidation. When Cu(OAc)2 was employed as the copper source and 1,1,3,3-tetramethylguanidine as an organic base, the reaction, optimally carried out overnight in DMSO at 80 °C in open air, produced a variety of amides and sulfonamides in moderate to excellent yields. This directing group has proven to be particularly efficient in C-H sulfonamidation.
authors.affiliation: Department of Chemistry, University of San Francisco , 2130 Fulton Street, San Francisco, California 94117, United States.
authors.forename: Wan-Chen Cindy
authors.initials: WC
authors.lastname: Lee
authors.affiliation: Department of Chemistry, University of San Francisco , 2130 Fulton Street, San Francisco, California 94117, United States.
authors.forename: Yuning
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Chemistry, University of San Francisco , 2130 Fulton Street, San Francisco, California 94117, United States.
authors.forename: David A
authors.initials: DA
authors.lastname: Gutierrez
authors.affiliation: Department of Chemistry, University of San Francisco , 2130 Fulton Street, San Francisco, California 94117, United States.
authors.forename: Jie Jack
authors.initials: JJ
authors.lastname: Li