title: Conservative Therapy is an Effective Option in Patients With Localized Infection After Penile Implant Surgery.
abstract: Traditionally, penile implant (PI) infections have been managed by removal with immediate or delayed replacement. Recently, interest has been focused on conservative therapy (CT) using antibiotic therapy.
  
  
  
  To investigate the success rate and predictive factors affecting the outcome of CT in PI infection patients.
  
  
  
  Patients diagnosed with early, localized PI infection were considered candidates for CT. Exclusion criteria included temperature >37.5°C, WBC >13,000/μL, and appearance of any sign of sepsis. In patients with purulent drainage, culture swabs were taken and an antibiotic was chosen based on sensitivity results. Oral antibiotics were used until the local infection was completely resolved. Patients were evaluated weekly during this process.
  
  
  
  Thirty-seven patients were retrospectively reviewed and constituted the study population. Mean age was 58.1 (range 37-85; SD 9.9) years. All were diabetic. Mean BMI was 31.8 (range 24-47; SD 5.0). PI was malleable in 33 cases and inflatable in 4 cases. Culture results (n = 19) included Staphylococcus epidermidis (42 %), pseudomonas (21%), Escherichia coli (21%), and S aureus (16%). Four of 37 patients needed the PI removed due to CT failure and onset of systemic symptoms, at a mean time-point of 75 ± 1.8 days after CT commencement. In men who were cured, mean time to complete healing was 49 (range 29-97; SD 15.8) days. Two of 37 patients (5%) had PI removal because of persistent penile pain despite complete wound healing, at a mean time point of 128 ± 2.5 days after CT commencement. All men managed conservatively resumed sexual intercourse.
  
  
  
  CT of localized PI infection appears to be a viable option for such patients, with the majority of patients retaining their implant and resuming sexual activity.
authors.affiliation: Elaj Medical Centers, Urology and Andrology Department, Jedda, Saudi Arabia. Electronic address: drmhabos@hotmail.com.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Habous
authors.affiliation: Al-azhar University, Urology Department, Cairo, Egypt.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Farag
authors.affiliation: University Hospitals Birmingham, Birmingham, UK.
authors.forename: Ben
authors.initials: B
authors.lastname: Williamson
authors.affiliation: King Khaled Hospital, Tabouk, Saudi Arabia.
authors.forename: Osama
authors.initials: O
authors.lastname: Laban
authors.affiliation: Elaj Medical Centers, Urology and Andrology Department, Jedda, Saudi Arabia.
authors.forename: Saad
authors.initials: S
authors.lastname: Mahmoud
authors.affiliation: Benha University, Urology Department, Benha, Egypt.
authors.forename: Osama
authors.initials: O
authors.lastname: Abdelwahab
authors.affiliation: Elaj Medical Centers, Urology and Andrology Department, Jedda, Saudi Arabia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Elkhouly
authors.affiliation: Elaj Medical Centers, Urology and Andrology Department, Jedda, Saudi Arabia.
authors.forename: Usama
authors.initials: U
authors.lastname: Kamil
authors.affiliation: Division of Urology, Department of Surgery, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Saleh
authors.initials: S
authors.lastname: Binsaleh
authors.affiliation: Male Sexual Dysfunction & Male Infertility, Urology Department, Rambam Health Care Campus, Haifa, Israel.
authors.forename: Raanan
authors.initials: R
authors.lastname: Tal
authors.affiliation: St Peters Andrology Centre &The Institute of Urology, UCLH, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Ralph
authors.affiliation: Sexual & Reproductive Medicine Program, Memorial Sloan Kettering Cancer Center, New York, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Mulhall
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003075:Coitus; D000072700:Conservative Treatment / Q000379:methods*; D020878:Device Removal / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D015917:Penile Prosthesis / Q000009:adverse effects*; D016459:Prosthesis-Related Infections / Q000209:etiology*; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents
keywords: Conservative Therapy; Implant; Infection; Penile Prosthesis; Salvage; Surgery