title: Interaction of BODIPY dyes with bovine serum albumin: a case study on the aggregation of a click-BODIPY dye.
abstract: The fluorescence of BODIPY and click-BODIPY dyes was found to substantially increase in the presence of bovine serum albumin (BSA). BSA acted as a solubilizer for dye aggregates, in addition to being a conventional binding scaffold for the click-BODIPY dyes, indicating that disaggregation of fluorophores should be considered when evaluating dye-protein interactions.
authors.affiliation: Department of Chemistry and Biochemistry, Texas Christian University, Fort Worth, TX 76129, USA. s.dzyuba@tcu.edu.
authors.forename: Laramie P
authors.initials: LP
authors.lastname: Jameson
authors.forename: Nicholas W
authors.initials: NW
authors.lastname: Smith
authors.forename: Onofrio
authors.initials: O
authors.lastname: Annunziata
authors.forename: Sergei V
authors.initials: SV
authors.lastname: Dzyuba
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000737:chemistry / Q000378:metabolism*; D002417:Cattle; D057930:Click Chemistry; D005456:Fluorescent Dyes / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D012710:Serum Albumin, Bovine