title: Regression of Intracranial Meningioma during Treatment with α1-Adrenoceptor Blocker.
abstract: Background Regression of meningioma has been reported after hemorrhage or hormonal withdrawal. Here, we report a case of an incidentally diagnosed meningioma that regressed in association with α1-adrenoceptor antagonist. Case report A 59-year old male patient with an incidentally diagnosed lateral sphenoid wing meningioma was followed with serial magnetic resonance imaging. The tumor with a maximum diameter of 43 mm showed progressive regression, and after 3 years the size was reduced to 22% of the initial volume. During follow-up the patient was treated with an α1-adrenoceptor antagonist (tamsulosin) for benign prostatic hyperplasia. Possible mechanisms are discussed, including our main hypothesis of reduced mitogenic effects through phospholipase C-signal transduction. Conclusion This is the first report of regression of an incidentally diagnosed meningioma associated with α1-adrenoceptor antagonist treatment.
authors.affiliation: Department of Neurosurgery, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Einar August
authors.initials: EA
authors.lastname: Hoegestoel
authors.affiliation: Department of Neurosurgery, Oslo University Hospital Rikshospitalet, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Jon
authors.initials: J
authors.lastname: Berg-Johnsen
keywords: intracranial; meningioma; regression; α1-blocker