title: Sero-Epidemiological Study of Hepatitis E Virus among Thalassemia as High Risk Patients: A Cross-Sectional Survey in Jahrom, Southern, Iran.
abstract: Hepatitis E virus (HEV) could be cause of viral hepatitis in the developing countries and cause severe epidemics. According to other studies, blood transfusion as a probable route of HEV infection has been suggested. An infection with hepatitis agents such as HEV causes active liver failure in multi-transfusion patients in particular thalassemia. The purpose of this study determines the seropositivity of anti-HEV antibodies in thalassemia individuals in Jahrom. In a cross-sectional study, sera from 110 thalassemia were collected between 2013 and 2014. Enzyme-linked immunosorbent assay (ELISA) method was performed to detection of anti-HEV antibodies. Individuals' data were collected such as, demographic and clinical, for statistical analysis. Our results show that 10% and 1.8% of the enrolled patients were HEV Ig-G and Ig-M positive antibodies respectively. In addition, there was statiscally significant difference in age groups for prevalence of anti-HEV Ig-G (P = 0.01). Also the serum levels of liver enzymes such as ALT and AST in the HEV Ig-G and Ig-M positive samples were significantly higher than anti-HEV negative samples. But there were no significant difference between sex and splenectomy with anti-HEV positive samples. The results indicate more study are needed to assess HEV screening of blood products to these patients that those have a probably risk of exposure to HEV especially in higher years old.
authors.affiliation: Zonoses Research Center, Jahrom University of Medical Sciences, Jahrom,. sotoodehj2002@yahoo.com.
authors.forename: Abdolreza
authors.initials: A
authors.lastname: Sotoodeh Jahromi
authors.forename: Abbas
authors.initials: A
authors.lastname: Ahmadi-Vasmehjani
authors.forename: Hassan
authors.initials: H
authors.lastname: Zabetian
authors.forename: Hossein
authors.initials: H
authors.lastname: Hakimelahi
authors.forename: Alireza
authors.initials: A
authors.lastname: Yusefi
authors.forename: Mohammad Sadegh
authors.initials: MS
authors.lastname: Sanie
authors.forename: Somayehsadat
authors.initials: S
authors.lastname: Talebnia Jahromi
authors.forename: Masoud
authors.initials: M
authors.lastname: Ghanei
authors.forename: Abdolali
authors.initials: A
authors.lastname: Sapidkar
authors.forename: Saiedeh
authors.initials: S
authors.lastname: Erfanian
authors.forename: Abdolhossien
authors.initials: A
authors.lastname: Madani
authors.forename: Farshid
authors.initials: F
authors.lastname: Kafilzadeh
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kargar
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hojjat-Farsangi