title: ApolipoproteinL1 is expressed in papillary thyroid carcinomas.
abstract: The apolipoprotein L (apoL) family has not yet been ascribed any definite patho-physiological function although the conserved BH3 protein domain suggests a role in programmed cell death. As repression of the regular apoptotic program is considered a hallmark of tumor progression, we investigated apoL expression in cancer. We show that the levels of one member of the family, apolipoprotein L1 (apoL1) is higher in papillary thyroid carcinoma compared to normal tissue. A combination of qRTPCR, immunohistochemistry and in situ hybridization allowed us to ascribe this increase to endogenous overexpression in carcinoma cells. Whether apoL1 plays an instrumental role in refraining cell death is the subject of ongoing molecular biology experiments.
authors.affiliation: Institute for Molecular Biology and Medicine (IBMM), Université Libre de Bruxelles, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium; Laboratory of Immunology, Department of Biochemistry, Faculty of Sciences, Lebanese University, Hadath, Beirut 21219, Lebanon.
authors.forename: Mounia
authors.initials: M
authors.lastname: Chidiac
authors.affiliation: Institute for Molecular Biology and Medicine (IBMM), Université Libre de Bruxelles, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Fayyad-Kazan
authors.affiliation: Institute for Molecular Biology and Medicine (IBMM), Université Libre de Bruxelles, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium.
authors.forename: Jalil
authors.initials: J
authors.lastname: Daher
authors.affiliation: Institute for Molecular Biology and Medicine (IBMM), Université Libre de Bruxelles, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium.
authors.forename: Philippe
authors.initials: P
authors.lastname: Poelvoorde
authors.affiliation: Laboratory of Translational Oncology, Institute of Pathology and Genetics/Grand Hôpital de Charleroi, Avenue Georges Lemaître 25, Gosselies, 6041, Belgium.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bar
authors.affiliation: Institute of Interdisciplinary Research (IRIBHM), Welbio, Université Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium.
authors.forename: Carine
authors.initials: C
authors.lastname: Maenhaut
authors.affiliation: Department of Pathology, Institute of Pathology and Genetics, Avenue Georges Lemaître 25, Gosselies, 6041, Belgium.
authors.forename: Paul
authors.initials: P
authors.lastname: Delrée
authors.affiliation: Laboratory of Immunology, Department of Biochemistry, Faculty of Sciences, Lebanese University, Hadath, Beirut 21219, Lebanon.
authors.forename: Bassam
authors.initials: B
authors.lastname: Badran
authors.affiliation: Institute for Molecular Biology and Medicine (IBMM), Université Libre de Bruxelles, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium; Laboratory of Experimental Medicine (ULB 222 Unit), Université Libre de Bruxelles, CHU de Charleroi, A. Vésale Hospital, Montigny-Le-Tilleul, Belgium. Electronic address: luc.vanhamme@ulb.ac.be.
authors.forename: Luc
authors.initials: L
authors.lastname: Vanhamme
mesh_terms: D000075944:Apolipoprotein L1; D001053:Apolipoproteins / Q000235:genetics / Q000378:metabolism*; D017209:Apoptosis; D002291:Carcinoma, Papillary / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008075:Lipoproteins, HDL / Q000235:genetics / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
chemical_list: C108666:APOL1 protein, human; D000075944:Apolipoprotein L1; D001053:Apolipoproteins; D008075:Lipoproteins, HDL
keywords: Apolipoprotein L1; Cancer; Papillary thyroid carcinoma