title: Exploring the molecular targets of dietary flavonoid fisetin in cancer.
abstract: The last few decades have seen a resurgence of interest among the scientific community in exploring the efficacy of natural compounds against various human cancers. Compounds of plant origin belonging to different groups such as alkaloids, flavonoids and polyphenols evaluated for their cancer preventive effects have yielded promising data, thereby offering a potential therapeutic alternative against this deadly disease. The flavonol fisetin (3,3',4',7-tetrahydroxyflavone), present in fruits and vegetables such as strawberries, apple, cucumber, persimmon, grape and onion, was shown to possess anti-microbial, anti-inflammatory, anti-oxidant and more significantly anti-carcinogenic activity when assessed in diverse cell culture and animal model systems. The purpose of this review is to update and discuss key findings obtained till date from in vitro and in vivo studies on fisetin, with special focus on its anti-cancer role. The molecular mechanism(s) described in the observed growth inhibitory effects of fisetin in different cancer cell types is also summarized. Moreover, an attempt is made to delineate the direction of future studies that could lead to the development of fisetin as a potent chemopreventive/chemotherapeutic agent against cancer.
authors.affiliation: Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
authors.forename: Deeba N
authors.initials: DN
authors.lastname: Syed
authors.affiliation: Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
authors.forename: Vaqar Mustafa
authors.initials: VM
authors.lastname: Adhami
authors.affiliation: Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
authors.forename: Naghma
authors.initials: N
authors.lastname: Khan
authors.affiliation: Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA.
authors.forename: Mohammad Imran
authors.initials: MI
authors.lastname: Khan
authors.affiliation: Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53706, USA. Electronic address: hmukhtar@wisc.edu.
authors.forename: Hasan
authors.initials: H
authors.lastname: Mukhtar
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D044948:Flavonols; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D044948:Flavonols; D010936:Plant Extracts; C017875:fisetin
keywords: Anti-oxidant; Apoptosis; Autophagy; Bioavailability; Cancer; Fisetin; Flavonoid; Invasion; Migration