title: Groenouw's macular dystrophy: Histochemistry and ultrastructure of the cornea.
abstract: Corneal macular dystrophy - Groenouw Type II - is related to a local deficiency of the hydrolytic enzyme α-Galactosidase. The disease originates from the stromal keratocytes and affects progressively Bowman's and Descemet's membranes.Examining such an affected cornea by means of light microscopy, histochemistry and electron microscopy, these findings were confirmed. In addition, we observed in the stroma vacuolated histiocytes with proteolitic activity invading the Bowman's and Descemet's membranes. Although obvious abnormalities of the corneal structures were disclosed, the endothelium appeared still to be normal.
authors.affiliation: Department of Pathology, Hadassah University Hospital and Medical School, Jerusalem, Israel.
authors.forename: N
authors.initials: N
authors.lastname: Livni
authors.affiliation: Department of Ophthalmology, Hadassah University Hospital and Medical School, Jerusalem, Israel.
authors.forename: F A
authors.initials: FA
authors.lastname: Abraham
authors.affiliation: Department of Ophthalmology, Hadassah University Hospital and Medical School, Jerusalem, Israel.
authors.forename: H
authors.initials: H
authors.lastname: Zauberman
keywords: Corneal Ultrastructure; Corneal dystrophy; Localised mucopolysaccharidosis; α-Galactosidase deficiency