title: Paradoxical role of SOX2 in gastric cancer.
abstract: Sox2 is a critical regulator of embryogenesis and necessary for cellular reprogramming. It also plays an important role in tissue homeostasis and regeneration, maintaining the population of undifferentiated adult stem cells. Like various developmental and stem cell genes, SOX2 is aberrantly expressed and amplified in several human cancers. Moreover, functional studies have shown that it regulates many biological processes including cell proliferation, apoptosis, self-renewal and invasion. While it is oncogenic in most cancers, SOX2 activity is controversial in gastric cancer, where it might behave as a tumor suppressor in some situations. In this review, we discuss its role in cancer biology, with particular attention to what is known about the involvement of SOX2 in gastric cancer biology.
authors.affiliation: Neurooncology group, Biodonostia Health Research Institute Paseo Dr. Beguiristain s/n, San Sebastian 20014, Spain.
authors.forename: Estefania
authors.initials: E
authors.lastname: Carrasco-Garcia
authors.affiliation: Unidade Integrada de Farmacologia e Gastroenterologia, Universidade São Francisco Bragança Paulista, SP, Brazil.
authors.forename: Juliana C
authors.initials: JC
authors.lastname: Santos
authors.affiliation: Neurooncology group, Biodonostia Health Research InstitutePaseo Dr. Beguiristain s/n, San Sebastian 20014, Spain; IKERBASQUE, Basque FoundationSpain.
authors.forename: Idoia
authors.initials: I
authors.lastname: Garcia
authors.affiliation: Unidade Integrada de Farmacologia e Gastroenterologia, Universidade São Francisco Bragança Paulista, SP, Brazil.
authors.forename: Mitsue
authors.initials: M
authors.lastname: Brianti
authors.affiliation: Neurooncology group, Biodonostia Health Research Institute Paseo Dr. Beguiristain s/n, San Sebastian 20014, Spain.
authors.forename: Mikel
authors.initials: M
authors.lastname: García-Puga
authors.affiliation: Unidade Integrada de Farmacologia e Gastroenterologia, Universidade São Francisco Bragança Paulista, SP, Brazil.
authors.forename: José
authors.initials: J
authors.lastname: Pedrazzoli
authors.affiliation: Neurooncology group, Biodonostia Health Research InstitutePaseo Dr. Beguiristain s/n, San Sebastian 20014, Spain; IKERBASQUE, Basque FoundationSpain.
authors.forename: Ander
authors.initials: A
authors.lastname: Matheu
authors.affiliation: Unidade Integrada de Farmacologia e Gastroenterologia, Universidade São Francisco Bragança Paulista, SP, Brazil.
authors.forename: Marcelo L
authors.initials: ML
authors.lastname: Ribeiro
keywords: H. pylori; SOX2; gastric cancer; stem cells