title: Human cryptosporidiosis in Europe.
abstract: Cryptosporidium has emerged as a significant cause of diarrhoeal disease worldwide, with severe health consequences for very young, malnourished children living in endemic areas and for individuals with highly impaired T-cell functions. In Europe, as elsewhere, the burden of disease has been difficult to measure as a result of the lack of appropriate, standardized surveillance and monitoring systems. The recent occurrence of large water- and foodborne outbreaks in several EU countries, as well as the results of many surveys of human and animal cryptosporidiosis, indicate that this parasite is widespread. Specific subtypes of the zoonotic Cryptosporidium parvum and the anthroponotic C. hominis are responsible for the majority of human cases in Europe. No treatment is currently available to clear the infection, but recent progress in genetic engineering of the parasite, coupled with advances in genomics, have opened important avenues for future research. Here we explore the possible reasons for underascertainment of cryptosporidiosis and the importance of accurate diagnosis in clinical management, the epidemiology of human cryptosporidiosis and key messages from recent outbreaks to highlight important interventions and emerging public health issues.
authors.affiliation: European Union Reference Laboratory for Parasites, Istituto Superiore di Sanità, Rome, Italy. Electronic address: simone.caccio@iss.it.
authors.forename: S M
authors.initials: SM
authors.lastname: Cacciò
authors.affiliation: Cryptosporidium Reference Unit, Public Health Wales, Singleton Hospital, Swansea, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: Chalmers
mesh_terms: D003457:Cryptosporidiosis / Q000175:diagnosis / Q000453:epidemiology* / Q000469:parasitology / Q000628:therapy; D003458:Cryptosporidium / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D004196:Disease Outbreaks; D005060:Europe / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D015995:Prevalence
keywords: Cryptosporidiosis; epidemiology; food; outbreaks; water