title: Neoalbaconol inhibits cell growth of human cholangiocarcinoma cells by up-regulating PTEN.
abstract: The recently isolated small-molecule neoalbaconol (NA) from Albatrellus confluens has been suggested to possess the ability to inhibit cell growth of many cancer cells. In this study, we investigated the role of NA in the regulation of cell apoptosis in human cholangiocarcinoma cell lines both in vitro and in vivo. Our results indicate that NA could induce cancer cell death via the AKT pathway by targeting phosphorate and tension homolog detected on chromosome 10 (PTEN) and supported the feasibility of NA being a novel chemotherapeutic treatment for human cholangiocarcinoma.
authors.affiliation: Department of Infectious Disease, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325027, China.
authors.forename: Guang-Yao
authors.initials: GY
authors.lastname: Zhou
authors.affiliation: Department of Infectious Disease, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325027, China.
authors.forename: Chen-Wei
authors.initials: CW
authors.lastname: Pan
authors.affiliation: Department of Infectious Disease, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325027, China.
authors.forename: Ling-Xiang
authors.initials: LX
authors.lastname: Jin
authors.affiliation: Wenzhou Key Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang 325000, China.
authors.forename: Jian-Jian
authors.initials: JJ
authors.lastname: Zheng
authors.affiliation: Department of Hepatobiliary Surgery, The Second Hospital of Nanjing, Affiliated to Southeast University Nanjing 210003, China.
authors.forename: Yong-Xiang
authors.initials: YX
authors.lastname: Yi
keywords: Neoalbaconol; PTEN; cholangiocarcinoma