title: No association of the single nucleotide polymorphism rs8044769 in the fat mass and obesity-associated gene with knee osteoarthritis risk and body mass index: A population-based study in China.
abstract: OBJECTIVE
  Previous genome-wide association studies (GWAS) have reported significant association of the single nucleotide polymorphism (SNP) rs8044769 in the fat mass and obesity-associated gene (FTO) with osteoarthritis (OA) risk in European populations. However, these findings have not been confirmed in Chinese populations.
  
  
  METHODS
  We systematically genotyped rs8044769 and evaluated the association between the genetic variants and OA risk in a case-controlled study including 196 OA cases and 442 controls in a northern Chinese population. Genotyping was performed using the Sequenom MassARRAY iPLEX platform.
  
  
  RESULTS
  We found that the variant T allele of rs8044769 showed no significant association of OA risk (p = 0.791), or association with body mass index (BMI) (pmeta = 0.786) in an additive genetic model. However, we detected a significant interaction between rs8044769 genotypes and BMI on OA risk (p = 0.037), as well as a borderline interaction between rs8044769 genotypes and age on OA risk (p = 0.062).
  
  
  CONCLUSIONS
  Our findings indicate that rs8044769 in the FTO gene may not modify individual susceptibility to OA or increased BMI in the Chinese population. Further studies are warranted to validate and extend our findings.Cite this article: Prof L. Jiang. No association of the single nucleotide polymorphism rs8044769 in the fat mass and obesity-associated gene with knee osteoarthritis risk and body mass index: A population-based study in China. Bone Joint Res 2016;5:169-174. DOI: 10.1302/2046-3758.55.2000589.
authors.affiliation: Department of Epidemiology, Nantong University, School of Public Health, Nantong, Jiangsu Province, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, Nantong University, School of Public Health, Nantong, Jiangsu Province, China.
authors.forename: M
authors.initials: M
authors.lastname: Chu
authors.affiliation: Department of Orthopedic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
authors.forename: J
authors.initials: J
authors.lastname: Rong
authors.affiliation: Hongqi Community Health Service Center, Xiangfang District, Harbin, Heilongjiang Province, China.
authors.forename: B
authors.initials: B
authors.lastname: Xing
authors.affiliation: Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang Province, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang Province, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology, Nantong University, School of Public Health, Nantong, Jiangsu Province, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhuang
authors.affiliation: Department of Epidemiology, Nantong University, School of Public Health, Nantong, Jiangsu Province, China J_meili@126.com.
authors.forename: L
authors.initials: L
authors.lastname: Jiang
keywords: FTO; OA; Susceptibility; rs8044769