title: Nephroprotection of lacidipine against gentamycin-induced nephrotoxicity in albino rats.
abstract: OBJECTIVE
  Gentamycin, a widely-used aminoglycoside antibiotic, is recognized as possessing significant nephrotoxic potential in human beings. Gentamycin-induced nephrotoxicity is suggested to be mediated via reactive oxygen species. The present study investigated the possible antioxidant nephroprotective effect of lacidipine as a calcium-channel blocker in a gentamycin-induced nephrotoxicity model in albino rats.
  
  
  METHODS
  Albino rats were divided into 3 groups. Group 1 received normal saline. Group 2 received gentamycin 80 mg/kg intraperitoneally for 14 days. Group 3 received lacidipine 1 mg/kg intraperitoneally 3 days before and 14 days concurrently with gentamycin. This dose does not affect the blood pressure of rats, as evidenced in the pilot study.
  
  
  RESULTS
  Gentamycin-induced nephrotoxicity was evidenced by a marked reduction in creatinine clearance. Treatment with lacidipine improved creatinine clearance compared to the gentamycin-treated group. In addition, it reduced thiobarbituric acid reactive substance, as an index of lipid peroxidation, with significant increases in superoxide dismutase enzyme in erythrocyte lysates and kidney catalase enzyme activities.
  
  
  CONCLUSIONS
  This study recommends the use of lacidipine in prophylaxis against gentamycin-induced nephrotoxicity.
authors.affiliation: Pharmacology Department, Faculty of Medicine, Ain Shams University, Cairo.
authors.forename: Sahar
authors.initials: S
authors.lastname: Kamal
keywords: albino rats; antioxidant; gentamycin; lacidipine; nephrotoxicity