title: Cutaneous manifestations and management of hematologic neoplasms.
abstract: Many malignant hematologic neoplasms can directly and indirectly involve the skin with lesions that are disfiguring, painful, and compromise integumentary function. The majority of lymphomas that directly infiltrate the skin are of T-cell origin but B-cell lymphomas, and other hematologic neoplasms, including acute myeloid and lymphoblastic leukemias, can also have cutaneous involvement, whereas some have an indolent course, eg, mycosis fungoides and marginal zone lymphoma, and easily respond to localized therapy with overall survival (OS) measured in years to decades. Others have a more clinically aggressive course, eg, natural killer (NK)/T-cell lymphoma and diffuse large B-cell lymphoma, leg type, that require high-dose multimodality therapy, and have an OS measured in months to a few years. Lymphoma can also lead to secondary cutaneous alterations, including a variety of paraneoplastic phenomena. We present an overview of direct and indirect skin involvement by malignant lymphocytes and other hematologic neoplasms. We also describe molecular and immunophenotypic aspects of these diseases and how they are treated.
authors.affiliation: Hematology Oncology Division, Department of Medicine, Vanderbilt University Medical Center, Nashville TN. Electronic address: olalekan.oluwole@vanderbilt.edu.
authors.forename: Olalekan O
authors.initials: OO
authors.lastname: Oluwole
authors.affiliation: Dermatology Division, Vanderbilt University Medical Center, Nashville TN.
authors.forename: John A
authors.initials: JA
authors.lastname: Zic
authors.affiliation: Hematopathology Division, Department of Pathology, Microbiology, and Immunology. Vanderbilt University Medical Center, Nashville TN.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Douds
authors.affiliation: Hematopathology Division, Department of Pathology, Microbiology, and Immunology. Vanderbilt University Medical Center, Nashville TN.
authors.forename: Mary
authors.initials: M
authors.lastname: Ann Thompson
authors.affiliation: Hematology Oncology Division, Department of Medicine, Vanderbilt University Medical Center, Nashville TN.
authors.forename: John P
authors.initials: JP
authors.lastname: Greer
mesh_terms: D019337:Hematologic Neoplasms / Q000145:classification / Q000276:immunology / Q000473:pathology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000209:etiology / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000473:pathology; D009182:Mycosis Fungoides / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000556:secondary
keywords: Anaplastic large cell lymphoma; Cutaneous B-cell lymphoma; Cutaneous T-cell lymphoma; Hodgkin lymphoma; Lymphoma; Paraneoplastic phenomena