title: Reproducibility of hippocampal atrophy rates measured with manual, FreeSurfer, AdaBoost, FSL/FIRST and the MAPS-HBSI methods in Alzheimer's disease.
abstract: The purpose of this study is to assess the reproducibility of hippocampal atrophy rate measurements of commonly used fully-automated algorithms in Alzheimer disease (AD). The reproducibility of hippocampal atrophy rate for FSL/FIRST, AdaBoost, FreeSurfer, MAPS independently and MAPS combined with the boundary shift integral (MAPS-HBSI) were calculated. Back-to-back (BTB) 3D T1-weighted MPRAGE MRI from the Alzheimer's Disease Neuroimaging Initiative (ADNI1) study at baseline and year one were used. Analysis on 3 groups of subjects was performed - 562 subjects at 1.5T, a 75 subject group that also had manual segmentation and 111 subjects at 3T. A simple and novel statistical test based on the binomial distribution was used that handled outlying data points robustly. Median hippocampal atrophy rates were -1.1%/year for healthy controls, -3.0%/year for mildly cognitively impaired and -5.1%/year for AD subjects. The best reproducibility was observed for MAPS-HBSI (1.3%), while the other methods tested had reproducibilities at least 50% higher at 1.5T and 3T which was statistically significant. For a clinical trial, MAPS-HBSI should require less than half the subjects of the other methods tested. All methods had good accuracy versus manual segmentation. The MAPS-HBSI method has substantially better reproducibility than the other methods considered.
authors.affiliation: VU University Medical Center, Amsterdam, Netherlands. Electronic address: keith@kscover.ca.
authors.forename: Keith S
authors.initials: KS
authors.lastname: Cover
authors.affiliation: VU University Medical Center, Amsterdam, Netherlands.
authors.forename: Ronald A
authors.initials: RA
authors.lastname: van Schijndel
authors.affiliation: VU University Medical Center, Amsterdam, Netherlands.
authors.forename: Adriaan
authors.initials: A
authors.lastname: Versteeg
authors.affiliation: UCL Institute of Neurology, London, United Kingdom.
authors.forename: Kelvin K
authors.initials: KK
authors.lastname: Leung
authors.affiliation: VU University Medical Center, Amsterdam, Netherlands.
authors.forename: Emma R
authors.initials: ER
authors.lastname: Mulder
authors.affiliation: VU University Medical Center, Amsterdam, Netherlands.
authors.forename: Remko A
authors.initials: RA
authors.lastname: Jong
authors.affiliation: VU University Medical Center, Amsterdam, Netherlands.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Visser
authors.affiliation: IRCCS San Giovanni di Dio Fatebenefratelli, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Redolfi
authors.affiliation: MAAT, Archamps, France.
authors.forename: Jerome
authors.initials: J
authors.lastname: Revillard
authors.affiliation: MAAT, Archamps, France.
authors.forename: Baptiste
authors.initials: B
authors.lastname: Grenier
authors.affiliation: MAAT, Archamps, France.
authors.forename: David
authors.initials: D
authors.lastname: Manset
authors.affiliation: Karolinska Institutet, Sweden.
authors.forename: Soheil
authors.initials: S
authors.lastname: Damangir
authors.affiliation: IRCCS San Giovanni di Dio Fatebenefratelli, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bosco
authors.affiliation: VU University Medical Center, Amsterdam, Netherlands.
authors.forename: Hugo
authors.initials: H
authors.lastname: Vrenken
authors.affiliation: VU University Medical Center, Amsterdam, Netherlands.
authors.forename: Bob W
authors.initials: BW
authors.lastname: van Dijk
authors.affiliation: IRCCS San Giovanni di Dio Fatebenefratelli, Italy; University Hospitals and University of Geneva, Switzerland.
authors.forename: Giovanni B
authors.initials: GB
authors.lastname: Frisoni
authors.affiliation: VU University Medical Center, Amsterdam, Netherlands.
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
mesh_terms: D000368:Aged; D000465:Algorithms; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D001284:Atrophy / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D059906:Neuroimaging / Q000379:methods*; D015203:Reproducibility of Results
keywords: Alzheimer disease; Atrophy; Automatic segmentation; Boundary shift integral; Hippocampus; Magnetic resonance imaging; Manual segmentation; Mild cognitive impairment