title: [Eales' disease].
abstract: The syndrome of recurrent vitreous hemorrhages in young men was described for the first time by Henry Eales in 1880. The association with a clinical manifestation of ocular inflammation was reported 5years later. Eales disease affects young adults who present with ischemic retinal vasculitis, with the peripheral retina most commonly affected. Most cases have been reported in South Asia. Although the etiology of this abnormality is unknown, it may be related to an immune sensitivity to Mycobacterium tuberculosis antigens. Its pathogenesis is related to extensive ischemia that affects the retina, secondary to an obliterative retinal vasculopathy with release of angiogenic factors of the VEGF type. Involvement of the retina is the hallmark of the disease, which manifests as follows: periphlebitis, retinal capillary ischemia most often affecting the periphery with secondary proliferative retinopathy and retinal and/or papillary neovascularization, recurrent vitreous hemorrhages and tractional retinal detachment. These complications are potentially blinding. The natural history of Eales disease varies, with temporary or permanent remission in some cases and continuous progression in others. Progression is often bilateral, which necessitates regular follow-up. The treatment of Eales disease depends on the stage of the disease and is not well defined. Observation only, pars plana vitrectomy surgery and/or intravitreal injections of anti-VEGF are recommended in cases of vitreous hemorrhage, associated with corticosteroids when retinal vasculitis is present. Laser pan-retinal photocoagulation is necessary when neovascularization is present.
authors.affiliation: Inserm-DHOS CIC 1423, service d'ophtalmologie IV, médecine interne, laboratoire, université Pierre-et-Marie-Curie-Paris 6, centre hospitalier national des Quinze-Vingts, DHU SightRestore, 28, rue de Charenton, 75012 Paris, France. Electronic address: marie-helene.errera@orange.fr.
authors.forename: M-H
authors.initials: MH
authors.lastname: Errera
authors.affiliation: Inserm-DHOS CIC 1423, service d'ophtalmologie IV, médecine interne, laboratoire, université Pierre-et-Marie-Curie-Paris 6, centre hospitalier national des Quinze-Vingts, DHU SightRestore, 28, rue de Charenton, 75012 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Pratas
authors.affiliation: Inserm-DHOS CIC 1423, service d'ophtalmologie IV, médecine interne, laboratoire, université Pierre-et-Marie-Curie-Paris 6, centre hospitalier national des Quinze-Vingts, DHU SightRestore, 28, rue de Charenton, 75012 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Goldschmidt
authors.affiliation: Inserm-DHOS CIC 1423, service d'ophtalmologie IV, médecine interne, laboratoire, université Pierre-et-Marie-Curie-Paris 6, centre hospitalier national des Quinze-Vingts, DHU SightRestore, 28, rue de Charenton, 75012 Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Sedira
authors.affiliation: Inserm-DHOS CIC 1423, service d'ophtalmologie IV, médecine interne, laboratoire, université Pierre-et-Marie-Curie-Paris 6, centre hospitalier national des Quinze-Vingts, DHU SightRestore, 28, rue de Charenton, 75012 Paris, France.
authors.forename: J-A
authors.initials: JA
authors.lastname: Sahel
authors.affiliation: Inserm-DHOS CIC 1423, service d'ophtalmologie IV, médecine interne, laboratoire, université Pierre-et-Marie-Curie-Paris 6, centre hospitalier national des Quinze-Vingts, DHU SightRestore, 28, rue de Charenton, 75012 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Benesty
mesh_terms: D000328:Adult; D006801:Humans; D017075:Laser Coagulation; D008297:Male; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D031300:Retinal Vasculitis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D014392:Tuberculosis, Ocular / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D014821:Vitrectomy; D055815:Young Adult
keywords: Bevacizumab; Bévacizumab; Décollement de la rétine; Eales disease; Idiopathic retinal periphlebitis; Maladie de Eales; Pars plana vitrectomy; Périphlébite rétinienne idiopathique; Retinal detachment; Tuberculose; Tuberculosis; Vitrectomie