title: Ubá mango juices intake decreases adiposity and inflammation in high-fat diet-induced obese Wistar rats.
abstract: OBJECTIVE
  The aim of this study was to determine the effect of Ubá mango juice with and without peel extract on the adiposity and inflammation modulation in high-fat diet-induced obese Wistar rats.
  
  
  METHODS
  The present study analyzed the total phenolic and antioxidant activity of the juices in different storage conditions. The biometry and biochemical parameters were evaluated in four experimental groups: normal control (AIN-93M), obese control (HFD), a group with obese rats plus control Ubá mango juice (MHFD), and another with enriched Ubá mango juice (HMHFD). Also, peroxisome proliferator-activated receptor gamma (PPAR-γ), lipoprotein lipase (LPL) and fatty acid synthase (FAS) expression, tumor necrosis factor-α (TNF-α ), and interleukin-10 (IL-10), as well as histomorphology of the epididymal adipose tissue were determined.
  
  
  RESULTS
  Ubá mango juices were found to have a high content of phenolic compounds and high antioxidant activity with no change due to storage time. HFD promoted the highest weight gain per gram of diet intake due to caloric density, and mango juices reversed the HFD effect; the weight gain, visceral fat, body mass index, and adiposity were similar to AIN-93M. MHFD and HMHFD showed antioxidant and anti-inflammatory effects by increasing HDL-cholesterol fraction and PPAR-γ, LPL, and decreasing blood glucose, total cholesterol, alanine aminotransferase (ATF), and FAS and TNF-α. Additionally, the epididymal adipose tissue histology confirmed the effect of the juice to reduce adipocyte hypertrophy.
  
  
  CONCLUSIONS
  The results showed that the Ubá mango has potential as a functional food that is capable of reducing metabolic risk for obesity associated with adiposity and inflammation.
authors.affiliation: Post-Graduate Program in Nutrition Science, Department of Nutrition and Health, Federal University of Vicosa, MG, Brazil. Electronic address: dorinanatal@gmail.com.
authors.forename: Dorina Isabel
authors.initials: DI
authors.lastname: Gomes Natal
authors.affiliation: Post-Graduate Program in Nutrition Science, Department of Nutrition and Health, Federal University of Vicosa, MG, Brazil.
authors.forename: Maria Eliza
authors.initials: ME
authors.lastname: de Castro Moreira
authors.affiliation: Department of Nutrition and Health, Federal University of Vicosa, MG, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Soares Milião
authors.affiliation: Department of Veterinary, Federal University of Vicosa, MG, Brazil.
authors.forename: Laércio
authors.initials: L
authors.lastname: Dos Anjos Benjamin
authors.affiliation: Department of Nutrition and Health, Federal University of Vicosa, MG, Brazil.
authors.forename: Maria Inês
authors.initials: MI
authors.lastname: de Souza Dantas
authors.affiliation: Department of Nutrition and Health, Federal University of Vicosa, MG, Brazil.
authors.forename: Sônia
authors.initials: S
authors.lastname: Machado Rocha Ribeiro
authors.affiliation: Department of Nutrition and Health, Federal University of Vicosa, MG, Brazil.
authors.forename: Hércia
authors.initials: H
authors.lastname: Stampini Duarte Martino
mesh_terms: D050154:Adiposity / Q000187:drug effects*; D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D000067030:Fruit and Vegetable Juices; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D031022:Mangifera; D009765:Obesity / Q000188:drug therapy*; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts
keywords: Gene expression; Inflammation; Mango; Obesity; Rats