title: In Situ Melanoma of the Gingiva Associated with Dense Inflammation and Pigment Deposition: A Potential Diagnostic Pitfall in Evaluating Stromal Invasion.
abstract: Melanoma is a highly aggressive neoplasm in which the neoplastic cells display melanocytic differentiation. Less than 1 % of all melanomas arise in the mucosal surfaces of the oral cavity, with purely in situ lesions being exceedingly rare tumors, but with a favorable prognosis compared with invasive lesions. We describe the clinical, histopathological and immunohistochemical findings in an uncommon case of in situ mucosal melanoma of the oral cavity with intense tumor-associated pigment deposition and inflammation complicating the morphological assessment of infiltrative areas.
authors.affiliation: School of Dentistry, Oral and Maxillofacial Pathology, University of São Paulo, São Paulo, Brazil.
authors.forename: Bruno Tavares
authors.initials: BT
authors.lastname: Sedassari
authors.affiliation: School of Dentistry, Stomatology, Santa Cecília University, Rua Oswaldo Cruz, Santos, SP, CEP: 11045-907, Brazil. ne_lascane@hotmail.com.
authors.forename: Nelise Alexandre da Silva
authors.initials: NA
authors.lastname: Lascane
authors.affiliation: School of Dentistry, Stomatology, Santa Cecília University, Rua Oswaldo Cruz, Santos, SP, CEP: 11045-907, Brazil.
authors.forename: André Luis Santana
authors.initials: AL
authors.lastname: de Freitas
authors.affiliation: School of Dentistry, Stomatology, Santa Cecília University, Rua Oswaldo Cruz, Santos, SP, CEP: 11045-907, Brazil.
authors.forename: Mário Cláudio
authors.initials: MC
authors.lastname: Mautoni
authors.affiliation: School of Medicine, Dermatopathology, University of São Paulo, São Paulo, Brazil.
authors.forename: Mirian Nacagami
authors.initials: MN
authors.lastname: Sotto
authors.affiliation: School of Dentistry, Oral and Maxillofacial Pathology, University of São Paulo, São Paulo, Brazil.
authors.forename: Marina Helena Cury
authors.initials: MH
authors.lastname: Gallottini
authors.affiliation: School of Dentistry, Oral and Maxillofacial Pathology, University of São Paulo, São Paulo, Brazil.
authors.forename: Suzana Cantanhede Orsini Machado
authors.initials: SC
authors.lastname: de Sousa
authors.affiliation: School of Dentistry, Oral and Maxillofacial Pathology, University of São Paulo, São Paulo, Brazil.
authors.forename: Décio Dos Santos
authors.initials: DD
authors.lastname: Pinto
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D005887:Gingival Neoplasms / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor
keywords: Immunohistochemistry; Mucosal melanoma; Oral mucosa; Skin tumors