title: New Delhi metallo-beta-lactamase-1-producing Acinetobacter spp. infection: report of a survivor.
abstract: New Delhi metallo-beta-lactamase-1 (NDM-1) is a bacterial enzyme that renders the bacteria resistant to a variety of beta-lactam antibiotics. A 20-year-old man was hospitalized several times for surgical treatment and complications caused by a right-sided vestibular schwannoma. Although the patient acquired several multidrug-resistant infections, this study focuses on the NDM-1-producing Acinetobacter spp. infection. As it was resistant to all antimicrobials tested, the medical team developed a 20-day regimen of 750mg/day metronidazole, 2,000,000IU/day polymyxin B, and 100mg/day tigecycline. The treatment was effective, and the patient recovered and was discharged from the hospital.
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Universidade do Sul de Santa Catarina, Tubarão, Santa Catarina, Brazil.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Schuelter-Trevisol
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Universidade do Sul de Santa Catarina, Tubarão, Santa Catarina, Brazil.
authors.forename: Graciane Jacinta
authors.initials: GJ
authors.lastname: Schmitt
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Universidade do Sul de Santa Catarina, Tubarão, Santa Catarina, Brazil.
authors.forename: Jane Martins de
authors.initials: JM
authors.lastname: Araújo
authors.affiliation: Comissão de Controle de Infecção Hospitalar, Hospital Nossa Senhora da Conceição, Tubarão, Santa Catarina, Brazil.
authors.forename: Liliane Braga de
authors.initials: LB
authors.lastname: Souza
authors.affiliation: Comissão de Controle de Infecção Hospitalar, Hospital Nossa Senhora da Conceição, Tubarão, Santa Catarina, Brazil.
authors.forename: Juliana Gomes
authors.initials: JG
authors.lastname: Nazário
authors.affiliation: Comissão de Controle de Infecção Hospitalar, Hospital Nossa Senhora da Conceição, Tubarão, Santa Catarina, Brazil.
authors.forename: Raquel Landuchi
authors.initials: RL
authors.lastname: Januário
authors.affiliation: Comissão de Controle de Infecção Hospitalar, Hospital Nossa Senhora da Conceição, Tubarão, Santa Catarina, Brazil.
authors.forename: Rogério Sobroza de
authors.initials: RS
authors.lastname: Mello
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Universidade do Sul de Santa Catarina, Tubarão, Santa Catarina, Brazil.
authors.forename: Daisson José
authors.initials: DJ
authors.lastname: Trevisol
mesh_terms: D000150:Acinetobacter / Q000187:drug effects / Q000201:enzymology*; D000151:Acinetobacter Infections / Q000188:drug therapy / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D016896:Treatment Outcome; D055815:Young Adult; D001618:beta-Lactamases
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1