title: Gold-Catalyzed Photoredox C(sp(2)) Cyclization: Formal Synthesis of (±)-Triptolide.
abstract: Photoexcitation of a dimeric gold complex showed the activation of a C(sp(2))-Br bond to generate a vinyl radical in a mild photoredox catalysis process. Use of [Au2(dppm)2]Cl2 with 365 nm LEDs in a photoredox catalysis process to produce polycyclic scaffolds using vinyl radicals is reported. This method achieved the synthesis of a small library of butenolide polycyclic compounds and naphthol polycyclic compounds. The efficacy of this photoredox process was further demonstrated by accomplishing the concise formal synthesis of (±)-triptolide.
authors.affiliation: Centre for Catalysis, Research and Innovation, Department of Chemistry and Biomolecular Science, University of Ottawa , 10 Marie Curie, Ottawa, Canada K1N 6N5.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Cannillo
authors.affiliation: Centre for Catalysis, Research and Innovation, Department of Chemistry and Biomolecular Science, University of Ottawa , 10 Marie Curie, Ottawa, Canada K1N 6N5.
authors.forename: Travis R
authors.initials: TR
authors.lastname: Schwantje
authors.affiliation: Centre for Catalysis, Research and Innovation, Department of Chemistry and Biomolecular Science, University of Ottawa , 10 Marie Curie, Ottawa, Canada K1N 6N5.
authors.forename: Maxime
authors.initials: M
authors.lastname: Bégin
authors.affiliation: Centre for Catalysis, Research and Innovation, Department of Chemistry and Biomolecular Science, University of Ottawa , 10 Marie Curie, Ottawa, Canada K1N 6N5.
authors.forename: Francis
authors.initials: F
authors.lastname: Barabé
authors.affiliation: Centre for Catalysis, Research and Innovation, Department of Chemistry and Biomolecular Science, University of Ottawa , 10 Marie Curie, Ottawa, Canada K1N 6N5.
authors.forename: Louis
authors.initials: L
authors.lastname: Barriault