title: Proton Pump Inhibitors Accelerate Endothelial Senescence.
abstract: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity.
  
  
  
  To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI-induced vascular dysfunction.
  
  
  
  Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length.
  
  
  
  Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal, and neurological morbidity and mortality.
authors.affiliation: From the Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, TX (G.Y., R.S., T.Z.N-.S., J.P.C.); Department of Chemical Physiology, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (M.P.); and Department of Radiation Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX (Y.T.G.).
authors.forename: Gautham
authors.initials: G
authors.lastname: Yepuri
authors.affiliation: From the Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, TX (G.Y., R.S., T.Z.N-.S., J.P.C.); Department of Chemical Physiology, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (M.P.); and Department of Radiation Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX (Y.T.G.).
authors.forename: Roman
authors.initials: R
authors.lastname: Sukhovershin
authors.affiliation: From the Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, TX (G.Y., R.S., T.Z.N-.S., J.P.C.); Department of Chemical Physiology, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (M.P.); and Department of Radiation Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX (Y.T.G.).
authors.forename: Timo Z
authors.initials: TZ
authors.lastname: Nazari-Shafti
authors.affiliation: From the Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, TX (G.Y., R.S., T.Z.N-.S., J.P.C.); Department of Chemical Physiology, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (M.P.); and Department of Radiation Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX (Y.T.G.).
authors.forename: Michael
authors.initials: M
authors.lastname: Petrascheck
authors.affiliation: From the Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, TX (G.Y., R.S., T.Z.N-.S., J.P.C.); Department of Chemical Physiology, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (M.P.); and Department of Radiation Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX (Y.T.G.).
authors.forename: Yohannes T
authors.initials: YT
authors.lastname: Ghebre
authors.affiliation: From the Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, TX (G.Y., R.S., T.Z.N-.S., J.P.C.); Department of Chemical Physiology, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (M.P.); and Department of Radiation Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX (Y.T.G.). jpcooke@houstonmethodist.org.
authors.forename: John P
authors.initials: JP
authors.lastname: Cooke
mesh_terms: D002460:Cell Line; D016922:Cellular Senescence / Q000187:drug effects*; D042783:Endothelial Cells / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D006801:Humans; D054328:Proton Pump Inhibitors / Q000494:pharmacology*
chemical_list: D054328:Proton Pump Inhibitors
keywords: aging; cardiovascular diseases; proteostasis deficiencies; proton pump inhibitors