title: Computed tomography dose optimisation in cystic fibrosis: A review.
abstract: Cystic fibrosis (CF) is the most common autosomal recessive disease of the Caucasian population worldwide, with respiratory disease remaining the most relevant source of morbidity and mortality. Computed tomography (CT) is frequently used for monitoring disease complications and progression. Over the last fifteen years there has been a six-fold increase in the use of CT, which has lead to a growing concern in relation to cumulative radiation exposure. The challenge to the medical profession is to identify dose reduction strategies that meet acceptable image quality, but fulfil the requirements of a diagnostic quality CT. Dose-optimisation, particularly in CT, is essential as it reduces the chances of patients receiving cumulative radiation doses in excess of 100 mSv, a dose deemed significant by the United Nations Scientific Committee on the Effects of Atomic Radiation. This review article explores the current trends in imaging in CF with particular emphasis on new developments in dose optimisation.
authors.affiliation: Helena Ferris, Maria Twomey, Fiachra Moloney, Siobhan B O'Neill, Kevin Murphy, Owen J O'Connor, Michael Maher, Department of Radiology, Cork University Hospital, Wilton, 001 Cork, Ireland.
authors.forename: Helena
authors.initials: H
authors.lastname: Ferris
authors.affiliation: Helena Ferris, Maria Twomey, Fiachra Moloney, Siobhan B O'Neill, Kevin Murphy, Owen J O'Connor, Michael Maher, Department of Radiology, Cork University Hospital, Wilton, 001 Cork, Ireland.
authors.forename: Maria
authors.initials: M
authors.lastname: Twomey
authors.affiliation: Helena Ferris, Maria Twomey, Fiachra Moloney, Siobhan B O'Neill, Kevin Murphy, Owen J O'Connor, Michael Maher, Department of Radiology, Cork University Hospital, Wilton, 001 Cork, Ireland.
authors.forename: Fiachra
authors.initials: F
authors.lastname: Moloney
authors.affiliation: Helena Ferris, Maria Twomey, Fiachra Moloney, Siobhan B O'Neill, Kevin Murphy, Owen J O'Connor, Michael Maher, Department of Radiology, Cork University Hospital, Wilton, 001 Cork, Ireland.
authors.forename: Siobhan B
authors.initials: SB
authors.lastname: O'Neill
authors.affiliation: Helena Ferris, Maria Twomey, Fiachra Moloney, Siobhan B O'Neill, Kevin Murphy, Owen J O'Connor, Michael Maher, Department of Radiology, Cork University Hospital, Wilton, 001 Cork, Ireland.
authors.forename: Kevin
authors.initials: K
authors.lastname: Murphy
authors.affiliation: Helena Ferris, Maria Twomey, Fiachra Moloney, Siobhan B O'Neill, Kevin Murphy, Owen J O'Connor, Michael Maher, Department of Radiology, Cork University Hospital, Wilton, 001 Cork, Ireland.
authors.forename: Owen J
authors.initials: OJ
authors.lastname: O'Connor
authors.affiliation: Helena Ferris, Maria Twomey, Fiachra Moloney, Siobhan B O'Neill, Kevin Murphy, Owen J O'Connor, Michael Maher, Department of Radiology, Cork University Hospital, Wilton, 001 Cork, Ireland.
authors.forename: Michael
authors.initials: M
authors.lastname: Maher
keywords: Computed tomography; Cystic fibrosis; Dose; Dose optimization; Ionising radiation; Kalydeco