title: Transdiagnostic factors across fibromyalgia and mental disorders: sleep disturbances may play a key role. A clinical review.
abstract: Sleep disturbances, affective disorders, pain and fatigue are often present in individuals affected by fibromyalgia (FM). The pathophysiology of FM is not yet well understood and, to date, no treatment has been proven to be fully effective in alleviating all symptoms. Adopting a transdiagnostic perspective could thus be useful for clinicians: treatment would target a transdiagnostic process across a range of disturbances, not just a single disorder. The aim of this review is to revise the available literature about the potential role of sleep disturbances as a transdiagnostic process in FM symptomatology and mood or anxiety disorders comorbidity. We are proposing a model under which sleep disturbances can play a central role. Because conditions of sleep loss are related to the activation of the stress system, including the activation of the inflammation system, we propose this mechanism as a key one: it can be shared by mental, sleep disturbances and pain in FM and it may explain, in part, the high levels of comorbidity between them. In this frame-work sleep disturbances may play a key role and be the target of therapeutic strategies across FM symptomatology and mental disorders.
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Palagini
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Italy. claudia.carmassi@unipi.it.
authors.forename: Claudia
authors.initials: C
authors.lastname: Carmassi
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Ciro
authors.initials: C
authors.lastname: Conversano
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Camilla
authors.initials: C
authors.lastname: Gesi
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Bazzichi
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Camillo
authors.initials: C
authors.lastname: Giacomelli
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Liliana
authors.initials: L
authors.lastname: Dell'Osso
mesh_terms: D015897:Comorbidity; D005356:Fibromyalgia / Q000175:diagnosis / Q000209:etiology / Q000523:psychology; D006801:Humans; D008962:Models, Theoretical; D010146:Pain / Q000503:physiopathology / Q000523:psychology; D012893:Sleep Wake Disorders / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology