title: Synthesis of sp(3)-rich scaffolds for molecular libraries through complexity-generating cascade reactions.
abstract: An efficient strategy for the synthesis of complex small molecules from simple building blocks is presented. Key steps of the strategy include tandem Petasis and Diels-Alder reactions, and divergent complexity-generating cyclization cascades from a key dialdehyde intermediate. The methodology is validated through the synthesis of a representative compound set, which has been used in the production of 1617 molecules for the European Lead Factory.
authors.affiliation: Department of Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. ten@kemi.dtu.dk mhc@kemi.dtu.dk.
authors.forename: T
authors.initials: T
authors.lastname: Flagstad
authors.forename: G
authors.initials: G
authors.lastname: Min
authors.forename: K
authors.initials: K
authors.lastname: Bonnet
authors.forename: R
authors.initials: R
authors.lastname: Morgentin
authors.forename: D
authors.initials: D
authors.lastname: Roche
authors.forename: M H
authors.initials: MH
authors.lastname: Clausen
authors.forename: T E
authors.initials: TE
authors.lastname: Nielsen