title: Metabolic syndrome and acute pancreatitis.
abstract: OBJECTIVE
  The aim of our study was to investigate the influence of metabolic syndrome on the course of acute pancreatitis determined by disease severity, the presence of local and systemic complications and survival rate.
  
  
  METHODS
  609 patients admitted to our hospital in the period from January 1, 2008 up to June 31, 2015 with the diagnosis of acute pancreatitis were analyzed. The diagnosis and the severity of acute pancreatitis were made according to the revised Atlanta classification criteria from 2012.
  
  
  RESULTS
  Of 609 patients with acute pancreatitis, 110 fulfilled the criteria for metabolic syndrome. Patients with metabolic syndrome had statistically significantly higher incidence of moderately severe (38.2% vs. 28.5%; p=0.05) and severe (22.7% vs. 12.8%; p=0.01) acute pancreatitis in comparison to those without metabolic syndrome, while patients without metabolic syndrome had higher incidence of mild acute pancreatitis in comparison to those patients with metabolic syndrome (58.7% vs. 39.1%; p<0.001). Patients with metabolic syndrome had a higher number of local and systemic complications, and higher APACHE II score in comparison to patients without metabolic syndrome. In multivariable logistic regression analysis, the presence of metabolic syndrome was independently associated with moderately severe and severe acute pancreatitis. Comparing survival rates, patients suffering from metabolic syndrome had a higher death rate compared to patients without metabolic syndrome (16% vs. 4.5%; p<0.001).
  
  
  CONCLUSIONS
  The presence of metabolic syndrome at admission portends a higher risk of moderately severe and severe acute pancreatitis, as well as higher mortality rate.
authors.affiliation: Department of Gastroenterology, UHC Rijeka, Croatia. Electronic address: ivana.mikolasevic@gmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Mikolasevic
authors.affiliation: Department of Gastroenterology, UHC Rijeka, Croatia.
authors.forename: S
authors.initials: S
authors.lastname: Milic
authors.affiliation: Department of Nephrology, Dialysis and Kidney Transplantation, UHC Rijeka, Croatia.
authors.forename: L
authors.initials: L
authors.lastname: Orlic
authors.affiliation: Department of Gastroenterology, UHC Rijeka, Croatia.
authors.forename: G
authors.initials: G
authors.lastname: Poropat
authors.affiliation: School of Medicine, Rijeka, Croatia.
authors.forename: I
authors.initials: I
authors.lastname: Jakopcic
authors.affiliation: Department of Gastroenterology, UHC Rijeka, Croatia.
authors.forename: N
authors.initials: N
authors.lastname: Franjic
authors.affiliation: School of Medicine, Rijeka, Croatia.
authors.forename: A
authors.initials: A
authors.lastname: Klanac
authors.affiliation: School of Medicine, Rijeka, Croatia.
authors.forename: N
authors.initials: N
authors.lastname: Kristo
authors.affiliation: Department of Nephrology, Dialysis and Kidney Transplantation, UHC Rijeka, Croatia.
authors.forename: D
authors.initials: D
authors.lastname: Stimac
mesh_terms: D018806:APACHE; D000208:Acute Disease; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D042882:Gallstones / Q000150:complications; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications; D015994:Incidence; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000378:metabolism; D008875:Middle Aged; D015999:Multivariate Analysis; D010195:Pancreatitis / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism; D019512:Pancreatitis, Alcoholic / Q000453:epidemiology / Q000378:metabolism; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D002097:C-Reactive Protein
keywords: Acute pancreatitis; Metabolic syndrome; Severity