title: Key factors for successful data integration in biomarker research.
abstract: Integrating a wide range of biomedical data such as that rapidly emerging from the use of next-generation sequencing is expected to have a key role in identifying and qualifying new biomarkers to support precision medicine. Here, we highlight some of the challenges for biomedical data integration and approaches to address them.
authors.affiliation: Bayer Pharma AG, Müllerstrasse 178, 13342 Berlin, Germany.
authors.forename: Antigoni
authors.initials: A
authors.lastname: Elefsinioti
authors.affiliation: Bayer Pharma AG, Müllerstrasse 178, 13342 Berlin, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Bellaire
authors.affiliation: Bristol-Myers Squibb, Princeton, New Jersey 08543, USA.
authors.forename: Albert
authors.initials: A
authors.lastname: Wang
authors.affiliation: Boehringer Ingelheim Pharma GmbH &Co. KG, 88397 Biberach an der Riss, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Quast
authors.affiliation: Bayer Pharma AG, Müllerstrasse 178, 13342 Berlin, Germany.
authors.forename: Henrik
authors.initials: H
authors.lastname: Seidel
authors.affiliation: F. Hoffmann-La Roche, New Jersey 10016, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Braxenthaler
authors.affiliation: Bayer Pharma AG, Müllerstrasse 178, 13342 Berlin, Germany.
authors.forename: Gernot
authors.initials: G
authors.lastname: Goeller
authors.affiliation: Bristol-Myers Squibb, Princeton, New Jersey 08543, USA.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Christianson
authors.affiliation: Bayer Pharma AG, Müllerstrasse 178, 13342 Berlin, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Henderson
authors.affiliation: AstraZeneca Personalized HealthCare and Biomarkers, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.|Bayer Pharma AG, Müllerstrasse 178, 13342 Berlin, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Reischl
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D035843:Biomedical Research; D003627:Data Interpretation, Statistical; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D008490:Medical Informatics / Q000379:methods*; D057285:Precision Medicine / Q000379:methods*; D018511:Systems Integration
chemical_list: D015415:Biomarkers