title: Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152.
abstract: Gamma-butyrolactones (GBLs) are signalling molecules that control antibiotic production in Streptomyces bacteria. The genetically engineered strain S. coelicolor M1152 was found to overproduce GBLs SCB1-3 as well as five novel GBLs named SCB4-8. Incorporation experiments using isotopically-labelled precursors confirmed the chemical structures of SCB1-3 and established those of SCB4-8.
authors.affiliation: Department of Chemistry and School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK. C.Corre@warwick.ac.uk.
authors.forename: John D
authors.initials: JD
authors.lastname: Sidda
authors.affiliation: Department of Chemistry and School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK. C.Corre@warwick.ac.uk.
authors.forename: Vincent
authors.initials: V
authors.lastname: Poon
authors.affiliation: Department of Chemistry and School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK. C.Corre@warwick.ac.uk.
authors.forename: Lijiang
authors.initials: L
authors.lastname: Song
authors.affiliation: State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, No. 1 West Beichen Road, Chaoyang District, Beijing 100101, People's Republic of China.
authors.forename: Weishan
authors.initials: W
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, No. 1 West Beichen Road, Chaoyang District, Beijing 100101, People's Republic of China.
authors.forename: Keqian
authors.initials: K
authors.lastname: Yang
authors.affiliation: Department of Chemistry and School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK. C.Corre@warwick.ac.uk.
authors.forename: Christophe
authors.initials: C
authors.lastname: Corre
mesh_terms: D015107:4-Butyrolactone / Q000737:chemistry* / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D005818:Genetic Engineering; D013058:Mass Spectrometry; D048372:Streptomyces coelicolor / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D015107:4-Butyrolactone