title: Detection of Serum Interleukin-6/10/18 Levels in Sepsis and Its Clinical Significance.
abstract: OBJECTIVE
  To explore the clinical significance of serum levels of IL-6/10/18 in sepsis.
  
  
  METHODS
  Sixty-six patients with sepsis were selected to be the case group. Additionally, 42 healthy adults were selected to be the control group. ELISA was used to measure the serum levels of IL-6/10/18, and ROC was utilized to evaluate the diagnostic values of IL-6/10/18 in sepsis.
  
  
  RESULTS
  The heart rate, respiratory rate, WBC count and APACHE II score in the sepsis group were significantly higher than those in the control group, and these indexes were increased in turn in the mild sepsis group, severe sepsis group, and septic shock group (all P < 0.05 after correction). The serum IL-6/18 levels in sepsis patients were significantly higher than those in the control group, and both of the levels were increased in turn in the mild sepsis group, severe sepsis group, and septic shock group (both P < 0.05). However, no significant difference was found in serum IL-10 level between groups (P > 0.05). The cut-off points of IL-6 and IL-18 were 109.19 pg/ml (sensitivity: 94.4%; specificity: 83.3%) and 116.01 pg/ml (sensitivity: 77.8%; specificity: 83.3%), respectively. Serum IL-6 levels were positively correlated with the APACHE II score and heart rate (both P < 0.001).
  
  
  CONCLUSIONS
  Serum levels of IL-6/8 are up-regulated in sepsis patients. Additionally, IL-6 has a greater sensitivity than IL-18. Serum IL-6 levels were positively correlated with the APACHE II score and heart rate, indicating that IL-6 could be used as a potential biomarker for sepsis.
authors.affiliation: Department of Intensive Medicine, Jining NO. 1 People's Hospital, Jining, China.
authors.forename: Mingchen
authors.initials: M
authors.lastname: Feng
authors.affiliation: Department of Operation Room, Jining NO.1 People's Hospital, Jining, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Sun
authors.affiliation: Department of Pharmacy, Jining NO.1 People's Hospital, Jining, China.
authors.forename: Yaxin
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Intensive Medicine, Jining NO. 1 People's Hospital, Jining, China. zhanghui201450@126.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D020382:Interleukin-18 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012119:Respiration; D012189:Retrospective Studies; D018805:Sepsis / Q000097:blood* / Q000503:physiopathology; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D016207:Cytokines; D020382:Interleukin-18; D015850:Interleukin-6; D016753:Interleukin-10
keywords: interleukin 10; interleukin 18; interleukin 6; receiver operating characteristic curve; sepsis; serum level