title: Rho, ROCK and actomyosin contractility in metastasis as drug targets.
abstract: Metastasis is the spread of cancer cells around the body and the cause of the majority of cancer deaths. Metastasis is a very complex process in which cancer cells need to dramatically modify their cytoskeleton and cope with different environments to successfully colonize a secondary organ. In this review, we discuss recent findings pointing at Rho-ROCK or actomyosin force (or both) as major drivers of many of the steps required for metastatic success. We propose that these are important drug targets that need to be considered in the clinic to palliate metastatic disease.
authors.affiliation: Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, Guy's Campus, King's College London, London, SE1 1UL, UK.
authors.forename: Irene
authors.initials: I
authors.lastname: Rodriguez-Hernandez
authors.affiliation: Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, Guy's Campus, King's College London, London, SE1 1UL, UK.
authors.forename: Gaia
authors.initials: G
authors.lastname: Cantelli
authors.affiliation: Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, Guy's Campus, King's College London, London, SE1 1UL, UK.|Department of Imaging Chemistry and Biology, Division of Imaging Sciences and Biomedical Engineering, St. Thomas Hospital, King's College London, London, SE1 7EH, UK.
authors.forename: Fanshawe
authors.initials: F
authors.lastname: Bruce
authors.affiliation: Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, Guy's Campus, King's College London, London, SE1 1UL, UK.
authors.forename: Victoria
authors.initials: V
authors.lastname: Sanz-Moreno
keywords: Rho; Rho-ROCK; actomyosin; metastasis