title: Multicenter study on invasive Streptococcus pyogenes infections in children in Argentina.
abstract: Invasive Streptococcus pyogenes infections (ISpIs) cause a high morbidity and mortality, even at present; however, at a regional level there are few publications on this subject in the field of pediatrics.
  
  
  
  To describe the prevalence, predisposing factors and clinical characteristics of children hospitalized for ISpI, and analyze risk factors associated with bacteremia and lethality. Material and methods. Retrospective, descriptive study on ISpIs in children <18 years old hospitalized in the Pediatric Ward of 20 healthcare facilities across Argentina between 2010 and 2012. Assessed outcome measures: age, gender, early and late clinical sources of infection, prior chronic condition, predisposing factors, treatment and evolution.
  
  
  
  To describe the prevalence, predisposing factors and clinical characteristics of children hospitalized for ISpI, and analyze risk factors associated with bacteremia and lethality. Material and methods. Retrospective, descriptive study on ISpIs in children <18 years old hospitalized in the Pediatric Ward of 20 healthcare facilities across Argentina between 2010 and 2012. Assessed outcome measures: age, gender, early and late clinical sources of infection, prior chronic condition, predisposing factors, treatment and evolution.
  
  
  
  Most ISpIs were observed in patients without a prior chronic condition. The most common manifestation was, frequently with bacteremia, in the skin and soft tissue. A statistically significant association was observed between bacteremia and ≥2 early sources of infection and no surgery. Fatality rate, in association with streptococcal toxic shock syndrome and necrotizing fasciitis, was similar to that observed in other publications.
authors.affiliation: Hospital de Niños Pedro de Elizalde, Ciudad Autónoma de Buenos Aires, Argentina. adcancel@intramed.net.
authors.forename: Aldo D
authors.initials: AD
authors.lastname: Cancellara
authors.affiliation: Hospital Pediátrico Dr. Notti, Villa Nueva de Guaymallén, Mendoza, Argentina.
authors.forename: Pablo
authors.initials: P
authors.lastname: Melonari
authors.affiliation: Hospital del Niño Jesús, San Miguel de Tucumán, Tucumán, Argentina.
authors.forename: María V
authors.initials: MV
authors.lastname: Firpo
authors.affiliation: Hospital de Niños Pedro de Elizalde, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Andrea
authors.initials: A
authors.lastname: Mónaco
authors.affiliation: Hospital de Niños Dr. Orlando Alassia, Santa Fe, provincia de Santa Fe, Argentina.
authors.forename: Gustavo C
authors.initials: GC
authors.lastname: Ezcurra
authors.affiliation: Hospital de Niños de la Santísima Trinidad, Córdoba, Argentina.
authors.forename: Lía
authors.initials: L
authors.lastname: Ruizf
authors.affiliation: Hospital de Niños "Víctor J. Vilela", Rosario, Santa Fe, Argentina.
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Aletti
authors.affiliation: Hospital A. Posadas, El Palomar, Buenos Aires, Argentina.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Gregorio
authors.affiliation: Hospital Materno Infantil de San Isidro, San Isidro, Buenos Aires, Argentina.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Gaiano
authors.affiliation: Hospital Infantil Municipal, Córdoba, Argentina.
authors.forename: Alberto
authors.initials: A
authors.lastname: Aird
authors.affiliation: Hospital Regional Ushuaia, Ushuaia, Tierra del Fuego, Argentina.|Hospital Regional de Río Grande, Río Grande, Tierra del Fuego, Argentina.
authors.forename: Luciana
authors.initials: L
authors.lastname: Bellone
authors.affiliation: Hospital Pediátrico del Niño Jesús, Córdoba, Argentina.
authors.forename: Miriam
authors.initials: M
authors.lastname: Calvari
authors.affiliation: Sanatorio Mater Dei, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Carolina
authors.initials: C
authors.lastname: Torregrosa
authors.affiliation: Hospital Pediátrico Dr. Avelino Castelán, Resistencia, Argentina.
authors.forename: Sandra
authors.initials: S
authors.lastname: Morinigo
authors.affiliation: Hospital Misericordia Nuevo Siglo, Barrio Güemes Capital, Córdoba, Argentina.
authors.forename: María L
authors.initials: ML
authors.lastname: Vozzan
authors.affiliation: Hospital Interzonal Penna, Bahía Blanca, provincia de Buenos Aires, Argentina.
authors.forename: Ivana
authors.initials: I
authors.lastname: Tonetto
authors.affiliation: Sanatorio de Niños, Rosario, Santa Fe, Argentina.|Hospital Italiano, Rosario, Santa Fe, Argentina.
authors.forename: Luis P
authors.initials: LP
authors.lastname: Flynn
authors.affiliation: CEMIC, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Bidone
authors.affiliation: Fundación Hospitalaria, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Carlota
authors.initials: C
authors.lastname: Russ
authors.affiliation: CEMIC, Ciudad Autónoma de Buenos Aires, Argentina.|Sanatorio Mater Dei, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Ellis
mesh_terms: D000293:Adolescent; D001118:Argentina; D016470:Bacteremia / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D013290:Streptococcal Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology; D013297:Streptococcus pyogenes
keywords: Necrotizing fasciitis; Streptococcus pyogenes; Toxic shock syndrome