title: Absorbable polymeric surgical clips for appendicular stump closure: A randomized control trial of laparoscopic appendectomy with lapro-clips.
abstract: A randomized control trial was performed to evaluate the effectiveness and safety of absorbable polymeric clips for appendicular stump closure in laparoscopic appendectomy (LA). Patients were randomly enrolled into an experimental group (ligation of the appendicular base with Lapro-Clips, L-C group) or control group (ligation of the appendicular base with Hem-o-lok Clips, H-C group). We identified 1,100 patients who underwent LA between April 1, 2012 and February 3, 2015. Overall, 99 patients (9.0%, 99/1,100) developed a complication following LA (47 [8.5%] in the L-C group and 52 [9.5%] in the H-C group (P = 0.598). No statistically significant differences were observed in intra-abdominal abscesses, stump leakage, superficial wound infections, post-operative abdominal pain, overall adverse events, or the duration of the operations and hospital stays between the groups (all p > 0.05). Adverse risk factors associated with the use of absorbable clips in LA included body mass index ≥ 27.5 kg/m2, diabetes, American Society of Anesthesiologists degree ≥ III, gangrenous appendicitis, severe inflammation of the appendix base, appendix perforation, and the absence of peritoneal drainage. The results indicate that the Lapro-Clip is a safe and effective device for closing the appendicular stump in LA in select patients with appendicitis.
authors.affiliation: General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, 610081, P.R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Lv
authors.affiliation: General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, 610081, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, 610081, P.R. China.|Central Laboratory, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, 610081, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, 610081, P.R. China.
authors.forename: Shusheng
authors.initials: S
authors.lastname: Leng
authors.affiliation: General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, 610081, P.R. China.
authors.forename: Shuqiang
authors.initials: S
authors.lastname: Li
authors.affiliation: General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, 610081, P.R. China.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, 610081, P.R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.affiliation: General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, 610081, P.R. China.
authors.forename: Jiatian
authors.initials: J
authors.lastname: Yuan
authors.affiliation: General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, 610081, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Fan
authors.affiliation: Central Laboratory, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, 610081, P.R. China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Xing
authors.affiliation: Pathology Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu, 610081, P.R. China.
authors.forename: Ci
authors.initials: C
authors.lastname: Li
mesh_terms: D020341:Absorbable Implants / Q000009:adverse effects; D000328:Adult; D001062:Appendectomy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D001064:Appendicitis / Q000453:epidemiology / Q000601:surgery*; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011108:Polymers / Q000009:adverse effects / Q000737:chemistry; D011183:Postoperative Complications / Q000453:epidemiology; D012086:Reoperation / Q000706:statistics & numerical data; D013525:Surgical Instruments / Q000009:adverse effects; D016896:Treatment Outcome; D058106:Wound Closure Techniques / Q000009:adverse effects / Q000295:instrumentation; D055815:Young Adult
chemical_list: D011108:Polymers
keywords: absorbable clip; appendicitis; appendix stump closure; laparoscopic appendectomy