title: Advances in Image-Guided Radiation Therapy for Primary Cardiac Angiosarcoma: The Role of PET-CT and MRI.
abstract: BACKGROUND
  With advances in modern diagnostic and therapeutic modalities, the main goal of intrathoracic radiation treatment is to reduce treatment-related toxicities. Here, we describe a series of cases that involved positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI)-based radiation therapy (RT) for the treatment of primary cardiac angiosarcoma (PCA).
  
  
  METHODS
  The medical records of 3 patients who underwent image-guided RT at our department between 2012 and 2015 were analyzed.
  
  
  RESULTS
  3 patients with PCA underwent pre-therapeutic imaging with fluorodeoxyglucose (FDG)-PET/CT (n = 3), as well as PET/MRI (n = 2) or MRI alone (n = 1). 2 patients underwent primary tumor resection (cases 1 and 2). The tumor in case 3 was unresectable and the patient underwent definitive chemoradiation. Intensity-modulated RT was applied with a median RT dose of 50.4 Gy. At the end of the study, 2 of the patients had survived for 35 and 16 months post-treatment (cases 1 and 3, respectively), and no evidence of tumor progression has since been detected.
  
  
  CONCLUSIONS
  For the cases examined, RT was a feasible and tolerable treatment for PCA, and FDG-PET-MRI successfully characterized each PCA for therapy planning.
authors.affiliation: Department of Radiation Oncology, University Hospital of Muenster, Muenster, Germany.
authors.forename: Khaled
authors.initials: K
authors.lastname: Elsayad
authors.forename: Sergiu
authors.initials: S
authors.lastname: Scobioala
authors.forename: Jan
authors.initials: J
authors.lastname: Kriz
authors.forename: Uwe
authors.initials: U
authors.lastname: Haverkamp
authors.forename: Hans Theodor
authors.initials: HT
authors.lastname: Eich
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D006338:Heart Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D006394:Hemangiosarcoma / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18