title: Histamine 2 Receptor Antagonists and Proton Pump Inhibitors.
abstract: Within the last 50 years, the pharmacologic market for gastric disease has grown exponentially. Currently, medical management with histamine 2 receptor antagonist and proton pump inhibitors are the mainstay of therapy over surgical intervention. These are generally regarded as safe medications, but there are growing numbers of cases documenting adverse effects, especially those manifesting in the skin. Here we review the pharmacology, common clinical applications, and adverse reactions of both histamine 2 receptor antagonists and proton pump inhibitors with a particular focus on the potential for allergic reactions including allergic contact dermatitis.
authors.affiliation: From the *Indiana University School of Medicine, and †Department of Dermatology, Indiana University School of Medicine, Indianapolis.
authors.forename: Megan D
authors.initials: MD
authors.lastname: Brinkworth
authors.forename: Mouhammad
authors.initials: M
authors.lastname: Aouthmany
authors.forename: Michael
authors.initials: M
authors.lastname: Sheehan
mesh_terms: D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D003875:Drug Eruptions / Q000209:etiology*; D006635:Histamine H2 Antagonists / Q000009:adverse effects*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D054328:Proton Pump Inhibitors / Q000009:adverse effects*
chemical_list: D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors