title: Ovarian large cell neuroendocrine carcinoma in the youngest woman.
abstract: Large cell neuroendocrine carcinoma (LCNC) of the ovary is a rare tumor in gynecologic oncologic field. An 18-year-old woman presented with abdominal distention and a pelvic mass measuring ten cm in diameter, who previously underwent laparoscopic ovarian cystectomy due to large borderline mucinous ovarian neoplasm 18 months prior. A debulking operation was optimally performed, which included total abdominal hysterectomy with bilateral salpingo-oophorectomy, bilateral pelvic lymph node dissection, bilateral paraaortic lymph node dissection, omentectomy, optimal debulking of gastrohepatic mass and subdiaphragmatic mass, and pelvic peritonectomy. Despite adjuvant chemotherapy with paclitaxel and carboplatin, the patient died of progressive disease seven months after surgery. The authors report the youngest case of LCNC of the ovary, that failed chemotherapy and had the previous history of the conservative surgical treatment due to mucinous borderline tumor.
authors.forename: Y S
authors.initials: YS
authors.lastname: Kwon
authors.forename: K S
authors.initials: KS
authors.lastname: Im
authors.forename: D I
authors.initials: DI
authors.lastname: Choi
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000188:drug therapy*; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D018287:Carcinoma, Large Cell / Q000175:diagnosis / Q000188:drug therapy*; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D065426:Cytoreduction Surgical Procedures; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007044:Hysterectomy; D064847:Multimodal Imaging; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D010052:Ovariectomy; D017239:Paclitaxel / Q000008:administration & dosage; D049268:Positron-Emission Tomography; D058994:Salpingectomy; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure
chemical_list: D016190:Carboplatin; D017239:Paclitaxel