title: Selective Thrombophilia Screening in Young Patients with Retinal Artery Occlusion.
abstract: OBJECTIVE
  To investigate the prevalence of various thrombophilic disorders among young patients with retinal artery occlusion (RAO).
  
  
  METHODS
  We retrospectively reviewed thrombophilia screening data of young patients ≤60 years of age with RAO and healthy controls matched for gender and age.
  
  
  RESULTS
  Thrombophilia screening data of 25 young patients and 62 healthy controls were analyzed. Mean patient age by the time of the RAO was 43.3 ± 10.8 years. Overall, thrombophilic defects were found to be present in 17 patients (68%) compared with 11 of 62 controls (17.7%; p < 0.0001). Multivariate logistic regression analysis confirmed a statistically significant association between the development of RAO and increased levels of lipoprotein(a) (odds ratio: 9.48; p = 0.001) and factor VIII (odds ratio: 6.41; p = 0.024). There was a strong association between the presence of thrombophilic disorders and a personal or family history of thromboembolism (p = 0.01).
  
  
  CONCLUSIONS
  Our results indicate that screening for thrombophilic disorders among selected young patients with RAO yields positive results in a high percentage of cases.
authors.affiliation: Klinik fx00FC;r Augenheilkunde, Klinikum der Johann Wolfgang Goethe-Universitx00E4;t Frankfurt am Main, Frankfurt am Main, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Kuhli-Hattenbach
authors.forename: Peter
authors.initials: P
authors.lastname: Hellstern
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Miesbach
authors.forename: Thomas
authors.initials: T
authors.lastname: Kohnen
authors.forename: Lars-Olof
authors.initials: LO
authors.lastname: Hattenbach
mesh_terms: D000328:Adult; D001780:Blood Coagulation Tests; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D015356:Retinal Artery Occlusion / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D055815:Young Adult