title: A Cue for Driving Large-Scale Cell Movement.
abstract: The earliest cell movements that initiate gastrulation in the vertebrate embryo have always fascinated embryologists, but signals controlling this large-scale morphogenesis where nearly all cells move have been elusive. Reporting in Developmental Cell, Szabó et al. (2016) uncover a mechanism for morphogenesis based on complement system C3a/C3aR-directed chemotaxis.
authors.affiliation: Developmental Biology, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany. Electronic address: driever@biologie.uni-freiburg.de.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Driever
mesh_terms: D000818:Animals; D002465:Cell Movement; D002633:Chemotaxis; D015926:Complement C3a / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000378:metabolism; D011951:Receptors, Complement / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D011951:Receptors, Complement; D015926:Complement C3a