title: 3D photography is a reliable method of measuring infantile haemangioma volume over time.
abstract: BACKGROUND
  Infantile haemangiomas are common lesions of infancy. With the development of novel treatments utilised to accelerate their regression, there is a need for a method of assessing these lesions over time. Volume is an ideal assessment method because of its quantifiable nature. This study investigated whether 3D photography is a valid tool for measuring the volume of infantile haemangiomas over time.
  
  
  METHODS
  Thirteen children with infantile haemangiomas presenting to the Vascular Anomalies Clinic, Royal Children's Hospital/Lady Cilento Children's Hospital treated with propranolol were included in the study. Lesion volume was assessed using 3D photography at presentation, one month and three months follow up. Intrarater reliability was determined by retracing all images several months after the initial mapping. Interrater reliability of the 3D camera software was determined by two investigators, blinded to each other's results, independently assessing infantile haemangioma volume.
  
  
  RESULTS
  Lesion volume decreased significantly between presentation and three-month follow-up (p<0.001). Volume intra- and interrater reliability were excellent with ICC 0.991 (95% CI 0.982, 0.995) and 0.978 (95% CI 0.955, 0.989), respectively.
  
  
  CONCLUSIONS
  This study demonstrates images taken with the 3D LifeViz™ camera and lesion volume calculated with Dermapix® software is a reliable method for assessing infantile haemangioma volume over time.
authors.affiliation: School of Medicine, University of Queensland, Brisbane, Australia. Electronic address: sarah.robertson@uqconnect.edu.au.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Robertson
authors.affiliation: Centre for Children's Health Research, Brisbane, Australia; Lady Cilento Children's Hospital, Brisbane, Australia. Electronic address: royk@uq.edu.au.
authors.forename: Roy M
authors.initials: RM
authors.lastname: Kimble
authors.affiliation: Lady Cilento Children's Hospital, Brisbane, Australia. Electronic address: Kristen.Storey@health.qld.gov.au.
authors.forename: Kristen J
authors.initials: KJ
authors.lastname: Storey
authors.affiliation: Centre for Children's Health Research, Brisbane, Australia. Electronic address: e.geekee@uq.edu.au.
authors.forename: Emma L
authors.initials: EL
authors.lastname: Gee Kee
authors.affiliation: Centre for Children's Health Research, Brisbane, Australia; Physiotherapy, Bond Institute of Health & Sport, Bond University, Gold Coast, Australia. Electronic address: k.stockton@uq.edu.au.
authors.forename: Kellie A
authors.initials: KA
authors.lastname: Stockton
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000359:Aftercare / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006391:Hemangioma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D021621:Imaging, Three-Dimensional; D007223:Infant; D008297:Male; D015588:Observer Variation; D010781:Photography / Q000379:methods*; D011433:Propranolol / Q000627:therapeutic use*; D015203:Reproducibility of Results; D047368:Tumor Burden
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol
keywords: 3D photography; Infantile haemangioma; Reliability; Volume