title: Choroidal Metastases From Cutaneous Melanoma.
abstract: A 92-year-old man presented with months of progressive blurry vision, worsening acutely in his right eye. He denied pain, diplopia, or photopsias. His history was significant for multiple myeloma, prostate cancer, and malignant melanoma of his right shoulder treated with local excision. He had local recurrence with hepatic metastasis of the melanoma treated with radiation and chemotherapy. On examination, his visual acuity was counting fingers in the right eye and 20/60 in the left eye. Amsler grid testing demonstrated metamorphopsia in the right eye. Fundus exam of the right and left eyes revealed multiple, elevated, pigmented choroidal lesions, with associated subretinal fluid in the right macula. This appearance is consistent with hematogenous metastasis of cutaneous malignant melanoma to the choroid and associated serous fluid-causing metamorphopsia. The patient was enrolled in a clinical trial combining plasmid IL-12 with pembrolizumab (Keytruda; Merck, Whitehouse Station, NJ). He passed away 2 months after initial presentation to our clinic. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:497.].
authors.forename: Carmel L
authors.initials: CL
authors.lastname: Mercado
authors.forename: Brian C
authors.initials: BC
authors.lastname: Toy
authors.forename: Henry B
authors.initials: HB
authors.lastname: Kistler
authors.forename: Darius M
authors.initials: DM
authors.lastname: Moshfeghi
mesh_terms: D000369:Aged, 80 and over; D002829:Choroid / Q000473:pathology*; D002830:Choroid Neoplasms / Q000175:diagnosis / Q000556:secondary*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology*; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D000096142:Cutaneous Malignant Melanoma