title: Poly(3,4-ethylenedioxythiophene):GlycosAminoGlycan Aqueous Dispersions: Toward Electrically Conductive Bioactive Materials for Neural Interfaces.
abstract: There is an actual need of advanced materials for the emerging field of bioelectronics. One commonly used material is the conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (
  
  
  
  PSS) due to its general use in organic electronics. However, depending on the application in bioelectronics,
  
  
  
  PSS is not fully biocompatible due to the high acidity of the residual sulfonate protons of PSS. In this paper, the synthesis and biocompatibility properties of new poly(3,4-ethylenedioxythiophene):GlycosAminoGlycan (
  
  
  
  GAG) aqueous dispersions and its resulting films are shown. Thus, negatively charged GAGs as an alternative to PSS are presented. Three different commercially available GAGs, hyaluronic acid, heparin, and chondroitin sulfate are used. Indeed,
  
  
  
  GAGs dispersions are prepared through an oxidative chemical polymerization in water. Biocompatibility assays of the
  
  
  
  GAGs coatings are performed using SH-SY5Y and CCF-STTG1 cell lines and with ATP and Ca(2+) . Results show full biocompatibility and a pronounced anti-inflammatory effect. This last characteristic becomes crucial if implanted in the body. These materials can be used for in vivo applications, as transistor or electrode for electrical recording and for all the possible situations when there is contact between electronic circuits and living tissues.
authors.affiliation: Institute for Polymer Materials (POLYMAT), University of the Basque Country UPV/EHU, Joxe Mari Korta Center, Avda. Tolosa 72, 20018, Donostia-san, Sebastian, Spain.
authors.forename: Daniele
authors.initials: D
authors.lastname: Mantione
authors.affiliation: Institute for Polymer Materials (POLYMAT), University of the Basque Country UPV/EHU, Joxe Mari Korta Center, Avda. Tolosa 72, 20018, Donostia-san, Sebastian, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Del Agua
authors.affiliation: Histocell, S.L, Science and Technology Park, 48170 Derio, Vizcaya, Spain.
authors.forename: Wandert
authors.initials: W
authors.lastname: Schaafsma
authors.affiliation: Histocell, S.L, Science and Technology Park, 48170 Derio, Vizcaya, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Diez-Garcia
authors.affiliation: Histocell, S.L, Science and Technology Park, 48170 Derio, Vizcaya, Spain.
authors.forename: Begona
authors.initials: B
authors.lastname: Castro
authors.affiliation: Institute for Polymer Materials (POLYMAT), University of the Basque Country UPV/EHU, Joxe Mari Korta Center, Avda. Tolosa 72, 20018, Donostia-san, Sebastian, Spain.
authors.forename: Haritz
authors.initials: H
authors.lastname: Sardon
authors.affiliation: Institute for Polymer Materials (POLYMAT), University of the Basque Country UPV/EHU, Joxe Mari Korta Center, Avda. Tolosa 72, 20018, Donostia-san, Sebastian, Spain.|Ikerbasque, Basque Foundation for Science, E-48011, Bilbao, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Mecerreyes
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000737:chemistry*; D002118:Calcium / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003116:Color; D004553:Electric Conductivity; D006025:Glycosaminoglycans / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007150:Immunohistochemistry; D007700:Kinetics; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010084:Oxidation-Reduction; D016716:PC12 Cells; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D014783:Viscosity; D014867:Water / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D019086:Bridged Bicyclo Compounds, Heterocyclic; D006025:Glycosaminoglycans; D011108:Polymers; C121383:poly(3,4-ethylene dioxythiophene); D014867:Water; D011189:Potassium Chloride; D000255:Adenosine Triphosphate; D006861:Hydrogen Peroxide; D002118:Calcium
keywords: GAGs; PEDOT; biocompatible; conductive polymers; neuroprotective