title: PET in Cerebrovascular Disease.
abstract: Investigation of the interplay between the cerebral circulation and brain cellular function is fundamental to understanding both the pathophysiology and treatment of stroke. At present, PET is the only technique that provides accurate, quantitative in vivo regional measurements of both cerebral circulation and cellular metabolism in human subjects. This article reviews normal human cerebral blood flow and metabolism, and human PET studies of ischemic stroke, carotid artery disease, vascular dementia, intracerebral hemorrhage, and aneurysmal subarachnoid hemorrhage, and discusses how these studies have added to the understanding of the pathophysiology of human cerebrovascular disease.
authors.affiliation: Department of Neurology, University of North Carolina School of Medicine, 170 Manning Drive-Room 2131, CB #7025, Chapel Hill, NC 27599-7025, USA. Electronic address: powersw@neurology.unc.edu.
authors.forename: William J
authors.initials: WJ
authors.lastname: Powers
authors.affiliation: Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, MO 63110, USA; Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA.
authors.forename: Allyson R
authors.initials: AR
authors.lastname: Zazulia
keywords: Cerebral blood flow; Cerebral hemodynamics; Cerebral metabolism; Cerebrovascular disease; Positron emission tomography; Vascular dementia