title: A new coumarin from the roots of Micromelum minutum.
abstract: A new coumarin, minutuminolate (1), together with eleven known coumarins (2-12), was isolated from the roots of Micromelum minutum. The structures of these compounds were established on the basis of their 1D and 2D NMR spectroscopic data. Compounds 2, 5, 10, 11 and 12 showed cytotoxicity against KB cell line. In addition, compounds 2, 3, 4, 7, 11 and 12 also showed weak cytotoxicity against NCI-H187 cell line.
authors.affiliation: a Faculty of Science, Natural Products Research Unit, Department of Chemistry, and Center for Innovation in Chemistry , Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Ratsami
authors.initials: R
authors.lastname: Lekphrom
authors.affiliation: a Faculty of Science, Natural Products Research Unit, Department of Chemistry, and Center for Innovation in Chemistry , Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Kwanjai
authors.initials: K
authors.lastname: Kanokmedhakul
authors.forename: Watchara
authors.initials: W
authors.lastname: Sangsopha
authors.affiliation: a Faculty of Science, Natural Products Research Unit, Department of Chemistry, and Center for Innovation in Chemistry , Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Somdej
authors.initials: S
authors.lastname: Kanokmedhakul
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D010936:Plant Extracts; C000617373:minutuminolate
keywords: Micromelum minutum; Rutaceae; coumarin; cytotoxicity