title: Reduced expression of serum miR-204 predicts poor prognosis of gastric cancer.
abstract: Deregulation of microRNAs (miRNAs) is implicated in the initiation and progression of gastric cancer (GC). Previous studies have demonstrated that miR-204 was downregulated in GC tissues. However, its expression profile in serum samples and its potential for clinical value remain unknown. Real-time PCR was performed to evaluate the expression level of serum miR-204 in patients with GC. The association between serum miR-204 expression level and the clinical outcome of GC was then investigated. Our results showed that the expression of miR-204 in serum samples from GC patients was significantly lower than that in the healthy controls (P < 0.01). Serum miR-204 expression level of GC patients was significantly upregulated after receiving surgical resection (P < 0.01). In addition, serum miR-204 was associated with lymph node metastasis (P = 0.016), tumor differentiation (P = 0.001), and TNM stage (P = 0.005). GC patients with low serum miR-204 expression had shorter overall survival than those with high serum miR-204 expression (P = 0.004). Multivariate analysis revealed that serum miR-204 expression level was an independent risk factor for this malignant disease (HR = 3.629, 95%CI = 2.828-8.146, P = 0.015). In conclusion, our findings indicate that serum miR-204 may be employed as a novel biomarker for monitoring the treatment response and predicting the prognosis of GC.
authors.affiliation: Qingdao University Medical College, Qingdao, Shandong, China.|Department of Gastroenterology, Yantai Municipal Laiyang Central Hospital, Yantai, Shandong, China.
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.affiliation: Qingdao University Medical College, Qingdao, Shandong, China.|Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: X S
authors.initials: XS
authors.lastname: Liu
authors.affiliation: Department of Infection Diseases, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: H Y
authors.initials: HY
authors.lastname: Liu
authors.affiliation: Qingdao University Medical College, Qingdao, Shandong, China.|Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Lu
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, Shandong, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000097:blood* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C549404:MIRN204 microRNA, human; D035683:MicroRNAs