title: Cichorium intybus root extract: A "vitamin D-like" active ingredient to improve skin barrier function.
abstract: During the aging process, the human skin suffers many alterations including dryness, skin barrier function damage. The skin barrier function is important to the prevention of skin alterations and maintenance of homeostasis. So, the objective of this study was to assess the clinical efficacy on skin barrier function of Cichorium intybus root extract in cosmetic formulations with or without UV filters. Fifty women, aged between 45 and 60 years, were divided into two groups. One group received vehicle formulations containing UV filters, and the other group received formulations without UV filters. Both groups received a formulation containing the extract and the vehicle. The formulations were applied twice daily to the upper arms after washing with sodium lauryl sulphate. Transepidermal water loss (TEWL) and skin microrelief were evaluated before and after a 14- and 28-day period of treatment. The control regions and regions where the vehicles were applied showed an increase in the TEWL. For the formulations containing the extract, decreased TEWL and improved microrelief were observed when compared to the vehicle and control areas after a 28-day period. In conclusion, Cichorium intybus root extract showed protective and restructuring effects on the skin and stands out as an innovative ingredient to improve skin barrier function.
authors.affiliation: a NEATEC, Faculty of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo , Ribeirao Preto , Brazil.
authors.forename: P M B G
authors.initials: PM
authors.lastname: Maia Campos
authors.affiliation: a NEATEC, Faculty of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo , Ribeirao Preto , Brazil.
authors.forename: D
authors.initials: D
authors.lastname: G Mercurio
authors.affiliation: a NEATEC, Faculty of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo , Ribeirao Preto , Brazil.
authors.forename: M
authors.initials: M
authors.lastname: O Melo
authors.affiliation: b R&D Department , SILAB , Brive Cedex , France.
authors.forename: B
authors.initials: B
authors.lastname: Closs-Gonthier
mesh_terms: D018651:Cichorium intybus / Q000737:chemistry*; D003358:Cosmetics / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D014870:Water Loss, Insensible
chemical_list: D003358:Cosmetics
keywords: TEWL; chicory extract; clinical study; photoprotective formulations; skin barrier function; vitamin D like