title: Long-term follow-up after bioresorbable vascular scaffold implantation in STEMI patients: PRAGUE-19 study update.
abstract: OBJECTIVE
  Early clinical results after implantation of bioresorbable vascular scaffolds (BVS) in ST-elevation myocardial infarction (STEMI) are encouraging, but long-term data are missing. This study evaluates long-term outcome in STEMI patients with implanted BVS.
  
  
  RESULTS
  The PRAGUE-19 study is an academic study enrolling consecutive STEMI patients with the intention to implant BVS. A total of 580 STEMI patients were screened between December 2012 and March 2015; 117 patients fulfilled entry criteria and BVS was successfully implanted in 114 (97%) of them. The primary combined clinical endpoint (death, reinfarction or target vessel revascularisation) occurred in 11.5% during the mean follow-up period of 730±275 days with overall mortality of 4.4%. Definite scaffold thrombosis occurred in two patients in the early phase after BVS implantation; there was no late thrombosis. Quantitative coronary angiography (10 patients) at three years demonstrated late lumen loss of 0.2±0.33 mm and optical coherence tomography showed minimal lumen area of 5.3±1.37 mm2 and neointimal hyperplasia area of 2.9±0.48 mm2. BVS struts were still visible at three years and 99.4% of them were well apposed and covered.
  
  
  CONCLUSIONS
  Encouraging clinical and imaging results after BVS implantation in STEMI patients persist during long-term follow-up.
authors.affiliation: Cardiocenter, Third Faculty of Medicine, Charles University in Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Toušek
authors.forename: Viktor
authors.initials: V
authors.lastname: Kočka
authors.forename: Martin
authors.initials: M
authors.lastname: Malý
authors.forename: Martin
authors.initials: M
authors.lastname: Kozel
authors.forename: Robert
authors.initials: R
authors.lastname: Petr
authors.forename: Martin
authors.initials: M
authors.lastname: Hajsl
authors.forename: Jiří
authors.initials: J
authors.lastname: Jarkovský
authors.forename: Libor
authors.initials: L
authors.lastname: Lisa
authors.forename: Tomáš
authors.initials: T
authors.lastname: Buděšínský
authors.forename: Petr
authors.initials: P
authors.lastname: Widimský
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D017023:Coronary Angiography / Q000379:methods; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000379:methods; D011474:Prosthesis Design / Q000379:methods; D000072657:ST Elevation Myocardial Infarction / Q000628:therapy*; D054457:Tissue Scaffolds; D041623:Tomography, Optical Coherence / Q000379:methods; D016896:Treatment Outcome