title: Waves of c-Fos and Arc Proteins Expression in Neuronal Populations of the Hippocampus in Response to a Single Episode of New Experience.
abstract: Accumulation of c-Fos and Arc proteins in neurons in different regions of the hippocampus after single trial of contextual fear conditioning was studied by using immunohistochemical staining. We found that the dynamics of the c-Fos and Arc expression has a biphasic pattern: the first peak was observed in 15-30 min after learning and the second less pronounced peak in 1-3 h. Induction of Arc occurred earlier than c-Fos and the overall dynamics of the two waves slightly varied in the dentate gyrus and hippocampal CA1 and CA3 fields. The findings open the possibility of mapping the cognitive neural networks of the brain with higher temporal resolution and draw attention to fluctuations of hippocampal activity after a single brief episode of new experience.
authors.affiliation: National Research Center Kurchatov Institute, Moscow, Russia. oivashkina@gmail.com.
authors.forename: O I
authors.initials: OI
authors.lastname: Ivashkina
authors.affiliation: National Research Center Kurchatov Institute, Moscow, Russia.
authors.forename: K A
authors.initials: KA
authors.lastname: Toropova
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Ivanov
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Chekhov
authors.affiliation: National Research Center Kurchatov Institute, Moscow, Russia.|P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: K V
authors.initials: KV
authors.lastname: Anokhin
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology; D056654:CA3 Region, Hippocampal / Q000166:cytology; D003213:Conditioning, Psychological / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D018891:Dentate Gyrus / Q000166:cytology; D005239:Fear / Q000502:physiology; D008297:Male; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D017966:Pyramidal Cells / Q000378:metabolism*
chemical_list: D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; D016760:Proto-Oncogene Proteins c-fos; C092069:activity regulated cytoskeletal-associated protein
keywords: Arc; c-Fos; hippocampus; immediate early genes; learning