title: Treatment of oral dysplasia with 5% imiquimod cream: short communication.
abstract: We report what we think is the first treatment of oral dysplasia with 5% imiquimod cream. A 60-year-old man presented with varying degrees of dysplasia on the soft palate. A cover plate was fabricated and the patient was prescribed 5% imiquimod cream, a topical imunomodulator, for six weeks. The lesion improved and histological examination of an incisional biopsy found no features of dysplasia. This case highlights the efficacy of imiquimod cream in the treatment of dysplasia, and the need for development of a preparation suitable for the oral mucosa.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Ninewells Hospital and Medical School, Dundee. Electronic address: r.mullins@nhs.net.
authors.forename: R
authors.initials: R
authors.lastname: Mullins
authors.affiliation: Department of Oral and Maxillofacial Surgery, Ninewells Hospital and Medical School, Dundee. Electronic address: mjansell@btinternet.com.
authors.forename: M
authors.initials: M
authors.lastname: Ansell
authors.affiliation: Department of Oral and Maxillofacial Surgery, Ninewells Hospital and Medical School, Dundee. Electronic address: slaverick@nhs.net.
authors.forename: S
authors.initials: S
authors.lastname: Laverick
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000287:Administration, Topical; D000634:Aminoquinolines / Q000627:therapeutic use*; D000970:Antineoplastic Agents; D001706:Biopsy; D006801:Humans; D000077271:Imiquimod; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000188:drug therapy*; D009824:Ointments; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D000970:Antineoplastic Agents; D009824:Ointments; D000077271:Imiquimod
keywords: Coverplate; Imiquimod; Non-surgical management; Oral dysplasia