title: Activated carbons as potentially useful non-nutritive additives to prevent the effect of fumonisin B1 on sodium bentonite activity against chronic aflatoxicosis.
abstract: Aflatoxin B1 (AFB1) and fumonisin B1 (FB1) are mycotoxins that often co-occur in feedstuffs. The ingestion of AFB1 causes aflatoxicosis in humans and animals. Sodium bentonite (NaB), a cheap non-nutritive unselective sequestering agent incorporated in animal diets, can effectively prevent aflatoxicosis. Fumonisins are responsible for equine leukoencephalomalacia and porcine pulmonary oedema, and often have subclinical toxic effects in poultries. Fumonisin B1 and aflatoxin B1 are both strongly adsorbed in vitro on sodium bentonite. Co-adsorption studies, carried out with a weight ratio of FB1 to AFB1 that mimics the natural occurrence (200:1), showed that FB1 greatly decreases the in vitro ability of NaB to adsorb AFB1. The ability of two activated carbons to adsorb FB1 was also investigated. Both carbons showed high affinity for FB1. A complex behaviour of the FB1 adsorption isotherms with pH was observed. In vitro results suggest that under natural contamination levels of AFB1 and FB1, a mixture of activated carbon and sodium bentonite might be potentially useful for prevention of sub-acute aflatoxicosis.
authors.affiliation: a Departamento de Química, Facultad de Ciencias Exactas, Físico , Químicas y Naturales Universidad Nacional de Río Cuarto , Río Cuarto , Argentina.
authors.forename: María Del Pilar
authors.initials: Mdel P
authors.lastname: Monge
authors.affiliation: a Departamento de Química, Facultad de Ciencias Exactas, Físico , Químicas y Naturales Universidad Nacional de Río Cuarto , Río Cuarto , Argentina.
authors.forename: Alejandra Paola
authors.initials: AP
authors.lastname: Magnoli
authors.affiliation: b Departamento de Microbiología e Inmunología, Facultad de Ciencias Exactas, Físico , Químicas y Naturales Universidad Nacional de Río Cuarto , Río Cuarto , Argentina.
authors.forename: Maria Virginia
authors.initials: MV
authors.lastname: Bergesio
authors.affiliation: c Cátedra Fisicoquímica y Laboratorio de Fisicoquímica de Superficies, DETEMA, Facultad de Química , Universidad de la Republica , Montevideo , Uruguay.
authors.forename: Nestor
authors.initials: N
authors.lastname: Tancredi
authors.affiliation: b Departamento de Microbiología e Inmunología, Facultad de Ciencias Exactas, Físico , Químicas y Naturales Universidad Nacional de Río Cuarto , Río Cuarto , Argentina.
authors.forename: Carina E
authors.initials: CE
authors.lastname: Magnoli
authors.affiliation: a Departamento de Química, Facultad de Ciencias Exactas, Físico , Químicas y Naturales Universidad Nacional de Río Cuarto , Río Cuarto , Argentina.
authors.forename: Stella Maris
authors.initials: SM
authors.lastname: Chiacchiera
mesh_terms: D000327:Adsorption; D016604:Aflatoxin B1 / Q000037:antagonists & inhibitors* / Q000737:chemistry; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D001546:Bentonite / Q000737:chemistry / Q000627:therapeutic use*; D002606:Charcoal / Q000008:administration & dosage* / Q000737:chemistry; D005052:Eucalyptus; D005503:Food Additives; D005506:Food Contamination / Q000032:analysis; D006734:Horse Diseases / Q000139:chemically induced / Q000517:prevention & control; D006736:Horses; D006801:Humans; D015651:Mycotoxicosis / Q000517:prevention & control / Q000662:veterinary*; D011201:Poultry Diseases / Q000139:chemically induced / Q000517:prevention & control; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced / Q000517:prevention & control; D014934:Wood
chemical_list: D005503:Food Additives; D001546:Bentonite; D002606:Charcoal; D016604:Aflatoxin B1
keywords: Aflatoxin B1; activated carbons; adsorption; fumonisin B1; sodium bentonite