title: Wear simulation of a polyethylene-on-metal cervical total disc replacement under different concentrations of bovine serum lubricant.
abstract: Metal-on-polyethylene total disc replacements have been an alternative to spinal fusion in the lumbar spine under certain indications for more than a decade. Recently, cervical total disc replacement has also become an alternative to cervical fusion. Knowledge acquired from years of in vitro simulator studies on other joint replacements has highlighted the risks associated with premature wear due to unforeseen adverse clinical conditions and the effect of particulate debris on surrounding natural tissues. Having no evidence of the type and composition of the lubricating fluid that will result after spinal arthroplasty, a study on the effects of lubricant serum concentration was undertaken. The wear rate was shown to be inversely proportional to protein content of the serum over a range of 50%-3% bovine serum to water concentration.
authors.affiliation: Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK School of Mechanical and Systems Engineering, Newcastle University, Newcastle upon Tyne, UK PhilipHyde8@gmail.com.
authors.forename: P J
authors.initials: PJ
authors.lastname: Hyde
authors.affiliation: Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK.
authors.forename: J
authors.initials: J
authors.lastname: Fisher
authors.affiliation: Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: Hall
mesh_terms: D000818:Animals; D002417:Cattle; D002574:Cervical Vertebrae / Q000601:surgery; D003198:Computer Simulation; D019544:Equipment Failure Analysis / Q000379:methods*; D054327:Lubricants / Q000737:chemistry*; D019216:Metals, Heavy / Q000737:chemistry*; D020959:Polyethylene / Q000737:chemistry*; D019736:Prostheses and Implants; D044967:Serum / Q000737:chemistry; D059145:Total Disc Replacement / Q000295:instrumentation*
chemical_list: D054327:Lubricants; D019216:Metals, Heavy; D020959:Polyethylene
keywords: Tribology; cervical; disc; serum; simulation; spine; total disc replacement; wear