title: Taurine supplementation attenuates delayed increase in exercise-induced arterial stiffness.
abstract: There is a delayed increase in arterial stiffness after eccentric exercise that is possibly mediated by the concurrent delayed increase in circulating oxidative stress. Taurine has anti-oxidant action, and taurine supplementation may be able to attenuate the increase in oxidative stress after exercise. The purpose of the present study was to investigate whether taurine supplementation attenuates the delayed increase in arterial stiffness after eccentric exercise. In the present double-blind, randomized, and placebo-controlled trial, we divided 29 young, healthy men into 2 groups. Subjects received either 2.0 g of placebo (n = 14) or taurine (n = 15) 3 times per day for 14 days prior to the exercise, on the day of exercise, and the following 3 days. The exercise consisted of 2 sets of 20 maximal-effort eccentric repetitions with the nondominant arm only. On the morning of exercise and for 4 days thereafter, we measured serum malondialdehyde (MDA) and carotid-femoral pulse wave velocity (cfPWV) as indices of oxidative stress and arterial stiffness, respectively. On the third and fourth days after exercise, both MDA and cfPWV significantly increased in the placebo group. However, these elevations were significantly attenuated in the taurine group. The increase in MDA was associated with an increase in cfPWV from before exercise to 4 days after exercise (r = 0.597, p < 0.05) in the placebo group, but not in the taurine group. Our results suggest that delayed increase in arterial stiffness after eccentric exercise was probably affected by the exercise-induced oxidative stress and was attenuated by the taurine supplementation.
authors.affiliation: a Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan.|b Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan.
authors.forename: Song-Gyu
authors.initials: SG
authors.lastname: Ra
authors.affiliation: a Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan.
authors.forename: Youngju
authors.initials: Y
authors.lastname: Choi
authors.affiliation: a Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Akazawa
authors.affiliation: a Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Ohmori
authors.affiliation: a Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Maeda
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D019587:Dietary Supplements; D004311:Double-Blind Method; D015444:Exercise; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D018384:Oxidative Stress / Q000187:drug effects; D063177:Pulse Wave Analysis; D013654:Taurine / Q000008:administration & dosage*; D059289:Vascular Stiffness / Q000187:drug effects*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D013654:Taurine; D008315:Malondialdehyde
keywords: arterial stiffness; eccentric exercise; exercice pliométrique; malonaldéhyde; malondialdehyde; oxidative stress; pulse wave velocity; rigidité artérielle; stress oxydatif; taurine; vitesse de l’onde de pouls