title: Estimating the probability of bacterial infection using a novel biomarker among pediatric patients in the emergency department.
abstract: BACKGROUND
  IL-27 is a novel biomarker to identify bacterial infection in children.
  
  
  OBJECTIVE
  IL-27 was evaluated among pediatric emergency department (ED) patients and compared with procalcitonin (PCT).
  
  
  RESULTS
  Children undergoing blood, urine, or cerebrospinal fluid cultures had IL-27 and PCT assays performed. Bacterial infection was defined as a positive culture or a clinical diagnosis based on chart review. IL-27 and PCT were increased among patients with bacterial infection and demonstrated comparable AUC's (0.62 versus 0.61). A decision tree incorporating IL-27, PCT, and white blood cell count improved the AUC (0.80).
  
  
  CONCLUSIONS
  IL-27 is a viable candidate biomarker to identify bacterial infection among ED patients and is comparable with PCT.
authors.affiliation: a Division of Emergency Medicine , Cincinnati Children's Hospital Medical Center , Cincinnati , OH , USA .|b Department of Pediatrics , University of Cincinnati College of Medicine , Cincinnati , OH , USA , and.
authors.forename: Michelle
authors.initials: M
authors.lastname: Eckerle
authors.affiliation: b Department of Pediatrics , University of Cincinnati College of Medicine , Cincinnati , OH , USA , and.|c Division of Critical Care Medicine , Cincinnati Children's Hospital Medical Center and Cincinnati Children's Hospital Research Foundation , Cincinnati , OH , USA.
authors.forename: Patrick
authors.initials: P
authors.lastname: Lahni
authors.affiliation: b Department of Pediatrics , University of Cincinnati College of Medicine , Cincinnati , OH , USA , and.|c Division of Critical Care Medicine , Cincinnati Children's Hospital Medical Center and Cincinnati Children's Hospital Research Foundation , Cincinnati , OH , USA.
authors.forename: Hector
authors.initials: H
authors.lastname: Wong
mesh_terms: D019540:Area Under Curve; D001424:Bacterial Infections / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid / Q000652:urine; D002116:Calcitonin / Q000032:analysis / Q000097:blood; D002648:Child; D003663:Decision Trees; D004636:Emergency Service, Hospital; D006801:Humans; D007378:Interleukins / Q000032:analysis*; D007958:Leukocyte Count; D011336:Probability
chemical_list: D015415:Biomarkers; D007378:Interleukins; C464565:MYDGF protein, human; D002116:Calcitonin
keywords: IL-27; Interleukin-27; procalcitonin; sepsis