title: Anaphylaxis after administration of amikacin containing sodium metabisulfite in a premature newborn.
abstract: Anaphylaxis is a serious systemic hypersensitivity reaction that is rapid in onset and can cause death. Premature newborns, whose immunological system is immature, are less likely to develop anaphylaxis. Administration of amikacin, containing sodium metabisulfite, to a 3-day-old premature newborn, induced a near fatal anaphylaxis. After suspicion of sepsis, the baby was started on amikacin. Clinical improvement was observed after initiation of treatment. On the third day of treatment with amikacin, the newborn suddenly developed tachypnea, tachycardia, angioedema and cyanosis. Anaphylaxis was diagnosed and treated. Latent reaction occurred after one hour of clinical improvement. The baby was intubated immediately. Anaphylaxis is a medical emergency; therefore the clinicians should have a rapid and careful assessment about this potentially fatal reaction. Even after successful treatment of anaphylaxis, the patient should be under observation for 72 hours because of the possibility of a biphasic reaction.
authors.affiliation: Department of Anesthesiology and Intensive Care, Cerrahpasa Medical School, İstanbul Üniversitesi, Istanbul, Turkey. pinarken@gmail.com.
authors.forename: Pinar
authors.initials: P
authors.lastname: Kendigelen
authors.forename: Mehmet
authors.initials: M
authors.lastname: BaktirClinic Of Anesthesiology And Reanimation Afşin State Hospital Afşin Kahramanmaraş Tureky
authors.affiliation: Clinic Of Pediatrics, Afşin State Hospital, Afşin, Kahramanmaraş, Turkey.
authors.forename: Asena
authors.initials: A
authors.lastname: Sucu
authors.affiliation: Department of Anesthesiology and Intensive Care, Cerrahpasa Medical School, İstanbul Üniversitesi, Istanbul, Turkey.
authors.forename: Guner
authors.initials: G
authors.lastname: Kaya
mesh_terms: D000583:Amikacin / Q000009:adverse effects*; D000707:Anaphylaxis / Q000209:etiology*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D013447:Sulfites / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D013447:Sulfites; C005200:sodium metabisulfite; D000583:Amikacin
keywords: Amikacin; Anaphylaxis; Premature infants; Sodium Metabisulfite