title: PO-08 - Venous thrombosis and cancer: about an Algerian series.
abstract: BACKGROUND
  Venous thromboembolism (VTE) and cancer is an association with increasing progression and poor prognosis. It always raises many issues including the question what is the exact incidence of occult cancer in a VTE? Is there a simple biological marker with a predictive value of this combination? Can we define a strategy thromboprophylaxis in cancer patients?
  
  
  OBJECTIVE
  To try to answer these questions we conducted a prospective study.
  
  
  METHODS
  We collected 140 patients with VTE, 70 of neoplastic origin ( group A) and 70 of other etiologies (Group B). The clinical and laboratory features of VTE associated with cancers are described and compared to those of VTE without cancer.
  
  
  RESULTS
  Among the results we can note that the average age of patients in group A is approximately 55 years; they are older than those of group B (55.6±14.5 vs 44.4±15.3, p<0.05), there are more unusual site vein thrombosis in group A than B (22.8 vs 10%, p<0.05), proximal venous lower extremities is predominant compared to a sural reached, in group A (84.8 vs 15.1%, p: 10(-6)), VTE discover neoplasia in 23% of cases, cancer is at the stage of recurrence in 14% of cases, the histological type was adenocarcinoma in 20% of cases; there are metastases at diagnosis in 53% of cases, LMWHs are prescribed in group A than B (55.7 vs 7.1%, p<0.05), mortality is higher in group A than B (91.4 vs 8.5%, p<0.05). Univariate statistical analysis allows to find discriminant variables between these two groups: female sex, age≥65 years, no thromboembolic personal history, thinness, surgery, unusual site deep venous thrombosis, bed rest, leukocytosis, anemia, hypoalbuminemia, hypocholesterolemia. Of these, five are identified by logistic regression. They are independent variables predictive of cancer before any VTE: absence of thromboembolic personal history, bed rest, unusual site vein thrombosis, anemia, leukocytosis.
  
  
  CONCLUSIONS
  Based on these five risk factors, our patients are scored in three increasing levels of risk of morbid association.
authors.affiliation: Internal medicine department ,CHU Mustapha.
authors.forename: M
authors.initials: M
authors.lastname: Berrah-Bennaceur
authors.affiliation: Internal medicine department, CHU Lamine Debaghine, Algeria.
authors.forename: A
authors.initials: A
authors.lastname: Berrah
authors.affiliation: Internal medicine department ,CHU Mustapha.
authors.forename: M
authors.initials: M
authors.lastname: Arrada