title: Anti-herpesviral effects of a novel broad range anti-microbial quaternary ammonium silane, K21.
abstract: We have created a novel quaternary ammonium silane, K21 through sol-gel chemistry, using an ethoxylated version of an organosilane quaternary ammonium compound and TetraEthyl Ortho Silicate (TEOS) as precursors. Previous studies using the precursor molecule quaternary ammonium compounds (QACs) and a methacryloxy version of K21, primarily designed for use in dental healthcare, have shown inhibited growth properties against several types of gram-positive and gram-negative bacteria including Escherichia coli, Streptococcus mutans, Actinomyces naeslundii and Candida albicans etc. Here we tested the effect of K21 on HSV-1, HHV-6A and HHV-7 in in vitro cell culture infection models. Our results show growth inhibitory effect of K21 on HSV-1, HHV-6A and HHV-7 infection.
authors.affiliation: Biocenter, Chair of Microbiology, University of Würzburg, 97074 Würzburg, Germany.
authors.forename: Nitish
authors.initials: N
authors.lastname: Gulve
authors.affiliation: KHG fiteBac Technology, Marietta, USA.
authors.forename: Kirk
authors.initials: K
authors.lastname: Kimmerling
authors.affiliation: DM Healthcare Products, Inc., San Diego, USA.
authors.forename: Allen D
authors.initials: AD
authors.lastname: Johnston
authors.affiliation: Department of Pathology and Laboratory Medicine, UT-Houston Medical School, Houston, USA.
authors.forename: Gerhard R
authors.initials: GR
authors.lastname: Krueger
authors.affiliation: HHV-6 Foundation, Santa Barbara, USA.
authors.forename: Dharam V
authors.initials: DV
authors.lastname: Ablashi
authors.affiliation: Biocenter, Chair of Microbiology, University of Würzburg, 97074 Würzburg, Germany. Electronic address: bhupesh.prusty@biozentrum.uni-wuerzburg.de.
authors.forename: Bhupesh K
authors.initials: BK
authors.lastname: Prusty
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000254:growth & development; D015654:Herpesvirus 6, Human / Q000187:drug effects* / Q000254:growth & development; D016199:Herpesvirus 7, Human / Q000187:drug effects* / Q000254:growth & development; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology*; D012821:Silanes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; C000624400:K21 compound; D000644:Quaternary Ammonium Compounds; D012821:Silanes
keywords: Anti-viral; HHV-6; HHV-7; HSV-1; QAC