title: A direct and vicinal functionalization of the 1-methyl-2-quinolone framework: 4-alkoxylation and 3-chlorination.
abstract: Bis(functionalization), 4-alkoxylation and 3-chlorination, of the 1-methyl-2-quinolone framework was achieved under mild conditions by a sequential treatment of 3-nitrated 1-methyl-2-quinolones with sodium alkoxide and N-chlorosuccinimide. Moreover, a succinimide group instead of an alkoxy group was introduced at the 4-position, affording a masked form of the 4-amino-3-chloro-2-quinolone derivative. Furthermore, the prepared vicinally functionalized quinolones thus obtained were subjected to a Suzuki-Miyaura coupling reaction, arylating the 3-position.
authors.affiliation: School of Environmental Science and Engineering, Kochi University of Technology, Miyanokuchi, Tosayamada, Kami, Kochi 782-8502, Japan. nishiwaki.nagatoshi@kochi-tech.ac.jp.
authors.forename: Feiyue
authors.initials: F
authors.lastname: Hao
authors.forename: Haruyasu
authors.initials: H
authors.lastname: Asahara
authors.forename: Nagatoshi
authors.initials: N
authors.lastname: Nishiwaki