title: The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance.
abstract: OBJECTIVE
  To detect MYB gene breaks in adenoid cystic carcinoma (ACC) of the salivary glands and its correlation with prognosis and selected clinical parameters
  
  
  METHODS
  MYB gene break was detected by FISH assay in 23 adenoid cystic carcinomas using formalin-fixed paraffin-embedded blocks. The Kaplan-Meier survival analysis was used to estimate prognosis.
  
  
  RESULTS
  Fifteen of 23 evaluated tumours were MYB positive and 8 MYB negative. The 10-year cumulative survival, respectively disease free interval, was 60.0%, respectively 59.3%, in MYB positive patients and 88.5%, respectively 80.0%, in MYB negative patients (long rank test, P=0.23). There were no significant differences in age, gender, perineural invasion, the presence of hematogenic or nodal metastases or degree of histopathological grading between MYB positive and MYB negative patients.
  
  
  CONCLUSIONS
  A tendency to differences in the survival of patients with ACC, depending on their MYB status. MYB negative patients were predisposed to better prognosis.
authors.affiliation: Department of Otorhinolaryngology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Broz
authors.affiliation: Bioptic Laboratory Ltd, Molecular Pathology Laboratory, Pilsen and Department of Pathology, Faculty of Medicine in Plzen, Charles University in Prague, Pilsen, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Steiner
authors.affiliation: Department of Otorhinolaryngology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
authors.forename: Richard
authors.initials: R
authors.lastname: Salzman
authors.affiliation: Department of Maxillofacial Surgery, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
authors.forename: Lukas
authors.initials: L
authors.lastname: Hauer
authors.affiliation: Department of Otorhinolaryngology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
authors.forename: Ivo
authors.initials: I
authors.lastname: Starek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000235:genetics* / Q000401:mortality; D005260:Female; D020570:Genes, myb / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000235:genetics* / Q000401:mortality
keywords: MYB gene; adenoid cystic carcinoma; prognosis; salivary gland