title: Positron Emission Tomography Imaging and Hyperinsulinism.
abstract: Congenital hyperinsulinism is the most important cause of recurrent hypoglycemia in infancy and can be caused by two different histopathologic lesions, a focal or a diffuse form, based on different molecular abnormalities despite an indistinguishable clinical pattern. The differential diagnosis between the two forms is pivotal because focal disease is potentially curable by selective resection of the pancreatic focus, whereas diffuse forms require a subtotal pancreatectomy. Different conventional imaging modalities and invasive selective arterial calcium stimulation have been used to identify the two forms of the disease. Positron emission tomography imaging is a widely recognized noninvasive modality that is now standard of care for many oncologic processes based on its metabolic and functional capabilities. Based on the properties of L-dihydroxyphenylalanine as a precursor of catecholamines, this paper reviews the current and future potential applications that this technology has in accurately diagnosing the two main forms of congenital hyperinsulinism.
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, 3470 Spruce Street, Philadelphia, PA 19104, USA.
authors.forename: Miguel
authors.initials: M
authors.lastname: Hernandez-Pampaloni
authors.affiliation: Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
authors.forename: Hongming
authors.initials: H
authors.lastname: Zhuang
authors.affiliation: Department of Nuclear Medicine, S Orsola Hospital, Bologna, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Fanti
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, 3470 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: abass.alavi@uphs.upenn.edu.
authors.forename: Abass
authors.initials: A
authors.lastname: Alavi
keywords: Fluorodopa; Hyperinsulinism; Pediatrics; Positron emission tomography