title: The diagnostic value of combination of TI-RADS and ultrasound elastography in the differentiation of benign and malignant thyroid nodules.
abstract: BACKGROUND
  Here, we evaluated the diagnostic value of combination of thyroid imaging-reporting and data system (TI-RADS) and ultrasound elastography (USE) in risk assessment of thyroid nodules.
  
  
  METHODS
  The clinical data of 174 patients with 232 nodules were retrospectively analyzed. All nodules were examined by gray-scale ultrasonography and USE and confirmed by histological examination.
  
  
  RESULTS
  The sensitivity, specificity, and accuracy of the combination of the two methods were significantly higher than those using a single method.
  
  
  CONCLUSIONS
  The combination of TI-RADS and USE has high diagnostic sensitivity and accuracy in evaluating the malignant risk of thyroid nodules.
authors.affiliation: Ultrasonic Department, Yantai Yuhuangding Hospital, Yantai, Shandong, 264000, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xue
authors.affiliation: Ultrasonic Department, Yantai Yuhuangding Hospital, Yantai, Shandong, 264000, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Cao
authors.affiliation: Ultrasonic Department, Yantai Yuhuangding Hospital, Yantai, Shandong, 264000, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.affiliation: Urology Department, Yantai Yuhuangding Hospital, Yantai, Shandong, 264000, China.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Lin
authors.affiliation: Central Laboratory, Yantai Yuhuangding Hospital, Yantai, Shandong, 264000, China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Wang
authors.affiliation: Ultrasonic Department, Yantai Yuhuangding Hospital, Yantai, Shandong, 264000, China. Electronic address: wangwangjn168@163.com.
authors.forename: Lihong
authors.initials: L
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D013961:Thyroid Gland / Q000000981:diagnostic imaging*; D013964:Thyroid Neoplasms / Q000175:diagnosis*; D016606:Thyroid Nodule / Q000175:diagnosis*
keywords: Elasticity imaging techniques; Thyroid imaging reporting and data system, TI-RADS; Thyroid nodule; Ultrasonography