title: Do Modic changes have an impact on clinical outcome in lumbar spine surgery? A systematic literature review.
abstract: To provide a systematic literature review of the impact of preoperative Modic changes (MCs) on the clinical outcome following lumbar spine surgery for degenerative lumbar spine disease.
  
  
  
  A PubMed search until 31 October 2015 was performed to identify publications correlating preoperative MC with clinical outcome in patients undergoing spine surgery.
  
  
  
  Inclusion criteria were met by 14 articles (7 prospective and 7 retrospective studies) representing a total of 1652 surgical patients, of which at least 804 (>49 %) showed MC. Of the 14 publications, 6 concerned discectomy (n = 607), 1 fusion versus discectomy (n = 91), 3 fusion surgery (n = 454), and 4 total disc replacement (TDR, n = 500). A trend toward less improvement in low back pain or Oswestry Disability Index score was found in the discectomy studies, and a trend toward increased improvement was demonstrated in the TDR studies when MC was present preoperatively. The fusion studies were of low evidence, and showed conflicting results.
  
  
  
  Preoperative MC showed a trend toward a negative correlation with clinical improvement in patients undergoing discectomy for LDH and a positive correlation with clinical improvement in patients undergoing TDR for degenerative disc disease. However, it is questionable whether the differences surpass the minimal clinically important difference (MCID). In patients undergoing fusion surgery, there was insufficient evidence to draw any conclusions. Future studies should include a larger patient material, focus on MCID, and include known confounding factors of the clinical outcome of spine surgery in the analysis.
authors.affiliation: Department of Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Nordre Ringvej 57, 2600, Glostrup, Denmark.
authors.forename: Aske Foldbjerg
authors.initials: AF
authors.lastname: Laustsen
authors.affiliation: Department of Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Nordre Ringvej 57, 2600, Glostrup, Denmark. rachid.bech-azeddine@regionh.dk.
authors.forename: Rachid
authors.initials: R
authors.lastname: Bech-Azeddine
mesh_terms: D017586:Diskectomy; D006801:Humans; D007403:Intervertebral Disc / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D055959:Intervertebral Disc Degeneration / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D057234:Preoperative Period; D013123:Spinal Fusion; D059145:Total Disc Replacement; D016896:Treatment Outcome
keywords: Clinical outcome; Fusion; Low back pain; Modic changes; Surgery; VESC