title: Relationship of serum uric acid level with non-alcoholic fatty liver disease and its inflammation progression in non-obese adults.
abstract: OBJECTIVE
  This study aimed to evaluate the relationship between serum uric acid (SUA) level and non-alcoholic fatty liver disease (NAFLD) in non-obese adults.
  
  
  METHODS
  A cross-sectional study was carried out among 4098 adults, including 1936 non-obese and 2162 obese individuals. An additional 93 non-obese adults with biopsy-proven NAFLD were also included.
  
  
  RESULTS
  The overall prevalence of NAFLD was 39.51% in the study group, and 14.88% in non-obese adults. The NAFLD patients had significantly higher SUA levels than controls in both men and women. The non-obese group had a higher NAFLD risk with increased SUA levels than the obese group, with odd ratios (95% confidence interval) of 2.559 (1.870-3.503) and 1.692 (1.371-2.087), respectively. In 93 non-obese adults with biopsy-proven NAFLD, SUA levels were significantly higher in those with non-alcoholic steatohepatitis. The prevalence of non-alcoholic steatohepatitis and lobule inflammation tended to increase to 57.58% and 66.67% as the SUA level increased to the fourth quartile. Subjects with hyperuricemia had significantly higher NAFLD activity scores and more serious lobule inflammation than the normal group.
  
  
  CONCLUSIONS
  Non-obese adults have higher NAFLD risk with increased SUA levels than obese individuals, and the inflammation progression of NAFLD is associated with increased SUA level in non-obese subjects.
authors.affiliation: Department of Liver Diseases, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Chengfu
authors.initials: C
authors.lastname: Xu
authors.affiliation: Dalian University of Medicine, Dalian, Liaoning, China.
authors.forename: Limei
authors.initials: L
authors.lastname: Ying
authors.affiliation: Department of Endocrine Diseases, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Shufei
authors.initials: S
authors.lastname: Zang
authors.affiliation: Center for Translational Medicine, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Zhenjie
authors.initials: Z
authors.lastname: Zhuang
authors.affiliation: Department of Surgical Intensive Care Unit, The First Affiliated Hospital of Zhejiang University, China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Lv
authors.affiliation: Department of Pathology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Yang
authors.affiliation: Center for Translational Medicine, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Liver Diseases, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Xaojie
authors.initials: X
authors.lastname: Ma
authors.affiliation: Second Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Liver Diseases, Xixi Hospital of Hangzhou, Hangzhou, Zhejiang, China.
authors.forename: Yunhao
authors.initials: Y
authors.lastname: Xun
authors.affiliation: Department of Medicine, Faculty of Medicine, The University of Hong Kong, China.
authors.forename: Dewei
authors.initials: D
authors.lastname: Ye
authors.affiliation: Department of Liver Diseases, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Junping
authors.initials: J
authors.lastname: Shi
keywords: inflammation progression; non-alcoholic fatty liver disease; non-obese adults; uric acid