title: Chemical Composition of the Essential Oil from the Fresh Fruits of Xylopia laevigata and its Cytotoxic Evaluation.
abstract: The essential oil obtained by hydrodistillation from the fresh fruits of Xylopia laevigata was analyzed by gas chromatography using a flame ionization detector (GC-FID) coupled to a mass spectrometer (GC-MS). Monoterpenes predominated, forming 95.0% of the total essential oil. The major constituents identified were limonene (56.2%), α-pinene (28.0%), and β-pinene (5.5%). Cytotoxic activity against tumor cell lines and non-tumor cells was also investigated; however, neither the essential oil nor its major constituents evaluated presented any cytotoxic activity (IC₅₀ > 25.0 µg mL⁻¹).
authors.forename: Emmanoel Vilaça
authors.initials: EV
authors.lastname: Costa
authors.forename: Thanany Brasil
authors.initials: TB
authors.lastname: da Silva
authors.forename: Cinara Oliveira D'Souza
authors.initials: CO
authors.lastname: Costa
authors.forename: Milena Botelho Pereira
authors.initials: MB
authors.lastname: Soares
authors.forename: Daniel Pereira
authors.initials: DP
authors.lastname: Bezerra
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D054336:Xylopia / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile; D010938:Plant Oils