title: Fungal Innate Immunity Induced by Bacterial Microbe-Associated Molecular Patterns (MAMPs).
abstract: Plants and animals detect bacterial presence through Microbe-Associated Molecular Patterns (MAMPs) which induce an innate immune response. The field of fungal-bacterial interaction at the molecular level is still in its infancy and little is known about MAMPs and their detection by fungi. Exposing Fusarium graminearum to bacterial MAMPs led to increased fungal membrane hyperpolarization, a putative defense response, and a range of transcriptional responses. The fungus reacted with a different transcript profile to each of the three tested MAMPs, although a core set of genes related to energy generation, transport, amino acid production, secondary metabolism, and especially iron uptake were detected for all three. Half of the genes related to iron uptake were predicted MirA type transporters that potentially take up bacterial siderophores. These quick responses can be viewed as a preparation for further interactions with beneficial or pathogenic bacteria, and constitute a fungal innate immune response with similarities to those of plants and animals.
authors.affiliation: Department of Plant and Environmental Sciences (PLEN), University of Copenhagen, Denmark.
authors.forename: Simon
authors.initials: S
authors.lastname: Ipcho
authors.affiliation: Department of Plant and Environmental Sciences (PLEN), University of Copenhagen, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Sundelin
authors.affiliation: Department of Plant and Environmental Sciences (PLEN), University of Copenhagen, Denmark.
authors.forename: Gitte
authors.initials: G
authors.lastname: Erbs
authors.affiliation: USDA ARS Cereal Disease Laboratory, St. Paul, Minnesota.
authors.forename: H Corby
authors.initials: HC
authors.lastname: Kistler
authors.affiliation: Department of Plant and Environmental Sciences (PLEN), University of Copenhagen, Denmark.
authors.forename: Mari-Anne
authors.identifier: 0000-0001-5782-6071
authors.initials: MA
authors.lastname: Newman
authors.affiliation: Department of Plant and Environmental Sciences (PLEN), University of Copenhagen, Denmark sto@plen.ku.dk.
authors.forename: Stefan
authors.identifier: 0000-0003-1931-9081
authors.initials: S
authors.lastname: Olsson
mesh_terms: D001419:Bacteria / Q000276:immunology*; D001483:Base Sequence; D001665:Binding Sites; D005658:Fungi / Q000187:drug effects* / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects; D007113:Immunity, Innate / Q000235:genetics; D008564:Membrane Potentials / Q000187:drug effects; D056265:Microbial Interactions / Q000187:drug effects* / Q000276:immunology*; D059372:Nucleotide Motifs; D000069452:Pathogen-Associated Molecular Pattern Molecules / Q000494:pharmacology*; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D000069452:Pathogen-Associated Molecular Pattern Molecules; D014157:Transcription Factors
keywords: MAMPs; fungal–bacterial interaction; innate immunity; transcriptomics