title: Bilateral Diffuse Uveal Melanocytic Proliferation Presenting as a Giant Unilateral Choroidal Nevus: A Case Report.
abstract: OBJECTIVE
  The aim of our study was to report a case of bilateral diffuse uveal melanocytic proliferation (BDUMP) with a markedly asymmetric presentation and fundoscopic response to palliative chemotherapy.
  
  
  METHODS
  We report a 67-year-old Caucasian man who presented with vision loss in his right eye. The best-corrected visual acuities were 2/10 in the right eye and 10/10 in the left eye, and biomicroscopy revealed bilateral mild cataracts. Fundoscopy of the right eye showed a macular flat and pigmented lesion extending beyond the posterior pole with areas of giraffe-type pigmentation and an overlying exudative retinal detachment. Nothing remarkable was detected in the left eye apart from a small round hypopigmented area of retinal pigment epithelium atrophy in the papillomacular bundle. BDUMP was diagnosed, and the workup for systemic malignancy revealed a pulmonary adenocarcinoma. After chemotherapy, not only did the right eye's visual acuity improve and the serous detachment resolve, but also the pigmentation decreased.
  
  
  CONCLUSIONS
  BDUMP presentation can be markedly asymmetric and resemble a giant unilateral choroidal nevus. Response to chemotherapy was unique not only for the usual retinal detachment resolution, but also because of an evident regression of pigmentation.
authors.affiliation: Department of Ophthalmology, Hospital Pedro Hispano, Matosinhos, Portugal.
authors.forename: Carlos
authors.initials: C
authors.lastname: Menezes
authors.affiliation: Department of Ophthalmology, Hospital Pedro Hispano, Matosinhos, Portugal.
authors.forename: Rui
authors.initials: R
authors.lastname: Carvalho
authors.affiliation: Department of Ophthalmology, Hospital Pedro Hispano, Matosinhos, Portugal; Clínica Oftalmológica Dr. Neves Martins, Porto, Portugal; Hospital Privado da Trofa, Trofa, Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Neves-Martins
authors.affiliation: Department of Ophthalmology, Hospital Pedro Hispano, Matosinhos, Portugal.
authors.forename: Carla
authors.initials: C
authors.lastname: Teixeira
keywords: Bilateral diffuse uveal melanocytic proliferation; Chemotherapy; Paraneoplastic retinopathy