title: A novel "complement-metabolism-inflammasome axis" as a key regulator of immune cell effector function.
abstract: The inflammasomes are intracellular multiprotein complexes that induce and regulate the generation of the key pro-inflammatory cytokines IL-1β and IL-18 in response to infectious microbes and cellular stress. The activation of inflammasomes involves several upstream signals including classic pattern or danger recognition systems such as the TLRs. Recently, however, the activation of complement receptors, such as the anaphylatoxin C3a and C5a receptors and the complement regulator CD46, in conjunction with the sensing of cell metabolic changes, for instance increased amino acid influx and glycolysis (via mTORC1), have emerged as additional critical activators of the inflammasome. This review summarizes recent advances in our knowledge about complement-mediated inflammasome activation, with a specific focus on a novel "complement - metabolism - NLRP3 inflammasome axis."
authors.affiliation: MRC Centre for Transplantation, Division of Transplant Immunology and Mucosal Biology, King's College London, London, UK.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Arbore
authors.affiliation: MRC Centre for Transplantation, Division of Transplant Immunology and Mucosal Biology, King's College London, London, UK.|Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
authors.forename: Claudia
authors.initials: C
authors.lastname: Kemper
mesh_terms: D000818:Animals; D003167:Complement Activation; D003165:Complement System Proteins / Q000276:immunology* / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000502:physiology*; D056747:Immunomodulation; D058847:Inflammasomes / Q000378:metabolism*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D058847:Inflammasomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D003165:Complement System Proteins
keywords: Complement; Metabolism; NLRP3 inflammasome