title: Shape effects of electrospun fiber rods on the tissue distribution and antitumor efficacy.
abstract: The significant impact of drug-loaded nanocarriers on cancer chemotherapy lies in the ability to specifically target to tumors with alleviated systemic toxicities. In the current study, a versatile and scalable method has been developed to construct fiber rods from electrospun fibers by ultrasonication using encapsulated NaCl nanoparticles as void-precursors. The shape effects of doxorubicin (DOX)-loaded fiber rods with an average diameter of around 500nm and different lengths are determined on the blood circulation, tumor accumulation and cellular uptake. Compared with microspheres, fiber rods indicate an up to 4-fold higher accumulation in tumors and an up to 3-fold longer terminal half-life of plasma DOX levels after intravenous injection. Fiber rods with shorter lengths show a significantly higher in vitro cytotoxicity to tumor cells, a higher DOX accumulation and cell necrosis in tumors, and a significantly lower metastasis in lungs. Among fiber rods with different lengths, fiber rods with an average length of 2μm induce significantly higher inhibition on tumor cell proliferation and induction of cell apoptosis, as wells as no detectable metastatic nodules in lung sections. Therefore, the shape effects of electrospun fiber rods hold great potential for enhancing systemic circulation and directing biodistribution to improve therapeutic outcomes.
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China.
authors.forename: Maohua
authors.initials: M
authors.lastname: Chen
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Luo
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China. Electronic address: xhli@swjtu.edu.cn.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D017209:Apoptosis; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D004337:Drug Carriers; D065546:Drug Liberation; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008298:Maleates / Q000737:chemistry; D008807:Mice, Inbred BALB C; D057139:Nanofibers / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*; D009368:Neoplasm Transplantation; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry; D017207:Rats, Sprague-Dawley; D013499:Surface Properties; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008298:Maleates; D011137:Polystyrenes; C520889:poly(styrene-alt-maleic anhydride); D011092:Polyethylene Glycols; D004317:Doxorubicin
keywords: Blood circulation; Cellular uptake; Electrospun fiber rod; Shape effect; Tumor accumulation