title: A Multiscale TiO2 Nanorod Array for Ultrasensitive Capture of Circulating Tumor Cells.
abstract: In this work, a uniform multiscale TiO2 nanorod array is fabricated to provide a "multi-scale interacting platform" for cell capture, which exhibits excellent capture specificity and sensitivity of the target cells after modification with bovine serum albumin (BSA) and DNA aptamer. After studying the capture performance of the BSA-aptamer TiO2 nanorod substrates and other nanostructured substrates, we can conclude that the multisacle TiO2 nanorod substrates could indeed effectively enhance the capture yields of target cancer cells. The capture yield of artificial blood samples on the BSA-aptamer TiO2 nanorod substrates is up to 85%-95%, revealing the potential application of the TiO2 nanorods on efficient and sensitive capture of rare circulating tumor cells.
authors.affiliation: Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Suzhou 215123, China.
authors.forename: Na
authors.initials: N
authors.lastname: Sun
authors.affiliation: Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Suzhou 215123, China.|State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, School of Pharmacy, Xi'an Jiaotong University , Xi'an 710049, China.
authors.forename: Xinpan
authors.initials: X
authors.lastname: Li
authors.affiliation: Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Suzhou 215123, China.
authors.forename: Zhili
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Suzhou 215123, China.|State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, School of Pharmacy, Xi'an Jiaotong University , Xi'an 710049, China.
authors.forename: Ruihua
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Suzhou 215123, China.
authors.forename: Jine
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Suzhou 215123, China.
authors.forename: Kewei
authors.initials: K
authors.lastname: Wang
authors.affiliation: Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Suzhou 215123, China.
authors.forename: Renjun
authors.initials: R
authors.lastname: Pei
mesh_terms: D002469:Cell Separation / Q000379:methods*; D006801:Humans; D061986:MCF-7 Cells; D043942:Nanotubes / Q000737:chemistry*; D009360:Neoplastic Cells, Circulating / Q000378:metabolism*; D014025:Titanium / Q000737:chemistry* / Q000378:metabolism
chemical_list: C009495:titanium dioxide; D014025:Titanium
keywords: TiO2 nanorod array; circulating tumor cells; high efficient capture; multiscale