title: A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition.
abstract: Pancreatitis-Panniculitis-Polyarthritis (PPP) syndrome is rare and its physiopathology unclear. A 6-year old boy suffered of traumatic pancreatitis complicated by PPP syndrome. Extensive investigations demonstrated high levels of pancreatic lipase and fatty acids in the affected peripheral tissues. These findings support the sequence of peripheral lipolysis and fatty acid accumulation inducing tissue inflammation.
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Ines
authors.initials: I
authors.lastname: Loverdos
authors.affiliation: Division of Plastic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Marc C
authors.initials: MC
authors.lastname: Swan
authors.affiliation: Division of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Shant
authors.initials: S
authors.lastname: Shekherdimian
authors.affiliation: Division of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Abdulrahman A
authors.initials: AA
authors.lastname: Al-Rasheed
authors.affiliation: Division of Rheumatology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Rayfel
authors.initials: R
authors.lastname: Schneider
authors.affiliation: Division of Plastic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Joel S
authors.initials: JS
authors.lastname: Fish
authors.affiliation: Division of Pathology, Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Bo-Yee
authors.initials: BY
authors.lastname: Ngan
authors.affiliation: Division of Clinical Biochemistry, Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Khosrow
authors.initials: K
authors.lastname: Adeli
authors.affiliation: Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Lowe
authors.affiliation: Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Vijay P
authors.initials: VP
authors.lastname: Singh
authors.affiliation: Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Wednesday Marie A
authors.initials: WM
authors.lastname: Sevilla
authors.affiliation: Division of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Jacob C
authors.initials: JC
authors.lastname: Langer
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
authors.forename: Tanja
authors.initials: T
authors.lastname: Gonska
keywords: Complicated pancreatitis; Pancreatitis; Pediatric pancreatitis; panniculitis and polyarthritis syndrome