title: Cross talk during the periconception period.
abstract: The cross talk between gametes, embryos, and female reproductive tract plays a crucial role in fine tuning of different reproductive events as well as influencing the epigenetic profile of offspring and their health in adulthood. Here, we describe some background to the recent investigations leading to the discovery of this cross talk. We will also point to important requirements for understanding the maternal communication with gametes and embryos. Finally, we mention two probable hypotheses regarding how gametes and embryos are recognized by the female reproductive tract. It is clear that understanding this cross talk is leading to the production of new means for increasing fertility and potentials for affecting the epigenomic profile of an individual.
authors.affiliation: Department of Oncology & Metabolism, Academic Unit of Reproductive and Developmental Medicine, The University of Sheffield, Sheffield, UK. Electronic address: A.Fazeli@sheffield.ac.uk.
authors.forename: Alireza
authors.initials: A
authors.lastname: Fazeli
authors.affiliation: Department of Oncology & Metabolism, Academic Unit of Reproductive and Developmental Medicine, The University of Sheffield, Sheffield, UK.
authors.forename: William V
authors.initials: WV
authors.lastname: Holt
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian / Q000502:physiology*; D044127:Epigenesis, Genetic; D005260:Female; D005306:Fertilization / Q000502:physiology*; D005836:Genitalia, Female / Q000502:physiology*; D005854:Germ Cells / Q000502:physiology*; D008322:Mammals / Q000502:physiology*; D011247:Pregnancy
keywords: Embryo; Fallopian tube; Oocyte; Oviduct; Periconception; Spermatozoa