title: Human Adaptive Natural Killer Cells: Beyond NKG2C.
abstract: Paradigm-shifting studies have identified NKG2C(+) adaptive natural killer (NK) cells in individuals infected with cytomegalovirus. Recently in Cell Reports, Liu et al. demonstrate that NKG2C(-/-) HCMV(+) individuals also generate adaptive NK cells, and reveal CD2 as a major co-stimulatory receptor for these NK cells specialized to respond via FcγRIIIa/CD16.
authors.affiliation: Department of Medicine, Division of Oncology, Washington University School of Medicine.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Wagner
authors.affiliation: Department of Medicine, Division of Oncology, Washington University School of Medicine. Electronic address: tfehnige@wustl.edu.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Fehniger
mesh_terms: D056704:Adaptive Immunity; D018801:CD2 Antigens / Q000378:metabolism*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory; D018664:Interleukin-12 / Q000378:metabolism; D019409:Interleukin-15 / Q000378:metabolism; D020382:Interleukin-18 / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D055654:NK Cell Lectin-Like Receptor Subfamily C / Q000378:metabolism*; D017452:Receptors, IgG / Q000378:metabolism*
chemical_list: D018801:CD2 Antigens; C496124:FCGR3A protein, human; D019409:Interleukin-15; D020382:Interleukin-18; C527059:KLRC2 protein, human; D055654:NK Cell Lectin-Like Receptor Subfamily C; D017452:Receptors, IgG; D018664:Interleukin-12