title: Diabetes insipidus and pregnancy.
abstract: Diabetes insipidus (DI) is a rare complication of pregnancy. It is usually transient, being due to increased placental production of vasopressinase that inactivates circulating vasopressin. Gestational, transient DI occurs late in pregnancy and disappears few days after delivery. Acquired central DI can also occur during pregnancy, for example in a patient with hypophysitis or neuroinfundibulitis during late pregnancy or postpartum. Finally, pre-existing central or nephrogenic DI may occasionally be unmasked by pregnancy. Treatment with dDAVP (desmopressin, Minirin(®)) is very effective on transient DI of pregnancy and also on pre-existing or acquired central DI. Contrary to vasopressin, dDAVP is not degraded by vasopressinase. Nephrogenic DI is insensitive to dDAVP and is therefore more difficult to treat during pregnancy if fluid intake needs to be restricted.
authors.affiliation: Service d'endocrinologie et des maladies de la reproduction, centre de référence des maladies endocriniennes rares de la croissance, hôpital de Bicêtre, hôpitaux universitaires Paris-Sud, Assistance publique-Hôpitaux de Paris (PC), 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France; Inserm 1185, faculté de médecine Paris-Sud, université Paris-Saclay, 94276 Le Kremlin-Bicêtre, France. Electronic address: philippe.chanson@bct.aphp.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Chanson
authors.affiliation: Service d'endocrinologie et des maladies de la reproduction, centre de référence des maladies endocriniennes rares de la croissance, hôpital de Bicêtre, hôpitaux universitaires Paris-Sud, Assistance publique-Hôpitaux de Paris (PC), 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Salenave
mesh_terms: D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000150:complications / Q000188:drug therapy / Q000209:etiology*; D020790:Diabetes Insipidus, Neurogenic / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000502:physiology*; D011248:Pregnancy Complications / Q000188:drug therapy; D014667:Vasopressins / Q000627:therapeutic use
chemical_list: D014667:Vasopressins; D003894:Deamino Arginine Vasopressin
keywords: Arginine vasopressine; Diabetes insipidus; Diabète insipide; Grossesse; Hypophysite; Hypophysitis; Placenta; Pregnancy; Vasopressinase