title: [The effect of sugammadex on postoperative cognitive function and recovery].
abstract: OBJECTIVE
  Sugammadex is the first selective relaxant binding agent. When compared with neostigmine, following sugammadex administration patients wake earlier and have shorter recovery times. In this study, we hypothesized that fast and clear awakening in patients undergoing general anesthesia has positive effects on cognitive functions in the early period after operation.
  
  
  METHODS
  Approved by the local ethical committee, 128 patients were enrolled in this randomized, prospective, controlled, double-blind study. Patients were allocated to either Sugammadex group (Group S) or the Neostigmine group (Group N). The primary outcome of the study was early postoperative cognitive recovery as measured by the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE). After baseline assessment 12-24h before the operation. After the operation, when the Modified Aldrete Recovery Score was ≥9 the MMSE and 1h later the MoCA tests were repeated.
  
  
  RESULTS
  Although there was a reduction in MoCA and MMSE scores in both Group S and Group N between preoperative and postoperative scores, there was no statistically significant difference in the slopes (p>0.05). The time to reach TOF 0.9 was 2.19min in Group S and 6.47min in Group N (p<0.0001). Recovery time was 8.26min in Group S and 16.93min in Group N (p<0.0001).
  
  
  CONCLUSIONS
  We showed that the surgical procedure and/or accompanying anesthetic procedure may cause a temporary or permanent regression in cognitive function in the early postoperative period. However, better cognitive performance could not be proved in the Sugammadex compared to the Neostigmine.
authors.affiliation: Departamento de Anestesiologia e Reanimação, School of Medicine, Bulent Ecevit University, Zonguldak, Turquia. Electronic address: drozcanp@gmail.com.
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Pişkin
authors.affiliation: Departamento de Anestesiologia e Reanimação, School of Medicine, Bulent Ecevit University, Zonguldak, Turquia.
authors.forename: Gamze
authors.initials: G
authors.lastname: Küçükosman
authors.affiliation: Provincial Health Directorate of Sanliurfa, Sanliurfa, Turquia.
authors.forename: Deniz Utku
authors.initials: DU
authors.lastname: Altun
authors.affiliation: Departamento de Anestesiologia e Reanimação, School of Medicine, Bulent Ecevit University, Zonguldak, Turquia.
authors.forename: Murat
authors.initials: M
authors.lastname: Çimencan
authors.affiliation: Departamento de Neurologia, School of Medicine, Bulent Ecevit University, Zonguldak, Turquia.
authors.forename: Banu
authors.initials: B
authors.lastname: Özen
authors.affiliation: Departamento de Anestesiologia e Reanimação, School of Medicine, Bulent Ecevit University, Zonguldak, Turquia.
authors.forename: Bengü Gülhan
authors.initials: BG
authors.lastname: Aydın
authors.affiliation: Departamento de Anestesiologia e Reanimação, School of Medicine, Bulent Ecevit University, Zonguldak, Turquia.
authors.forename: Rahşan Dilek
authors.initials: RD
authors.lastname: Okyay
authors.affiliation: Departamento de Anestesiologia e Reanimação, School of Medicine, Bulent Ecevit University, Zonguldak, Turquia.
authors.forename: Hilal
authors.initials: H
authors.lastname: Ayoğlu
authors.affiliation: Departamento de Anestesiologia e Reanimação, Ankara Numune Practice and Research Hospital, Ankara, Turquia.
authors.forename: Işıl Özkoçak
authors.initials: IÖ
authors.lastname: Turan
keywords: Disfunção cognitiva no pós‐operatório; MMSE; MoCA; Neostigmina; Neostigmine; Postoperative cognitive dysfunction; Sugamadex; Sugammadex