title: BDDCS, the Rule of 5 and drugability.
abstract: The Rule of 5 methodology appears to be as useful today in defining drugability as when it was proposed, but recognizing that the database that we used includes only drugs that successfully reached the market. We do not view additional criteria necessary nor did we find significant deficiencies in the four Rule of 5 criteria originally proposed by Lipinski and coworkers. BDDCS builds upon the Rule of 5 and can quite successfully predict drug disposition characteristics for drugs both meeting and not meeting Rule of 5 criteria. More recent expansions of classification systems have been proposed and do provide useful qualitative and quantitative predictions for clearance relationships. However, the broad range of applicability of BDDCS beyond just clearance predictions gives a great deal of further usefulness for the combined Rule of 5/BDDCS system.
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, USA.
authors.forename: Leslie Z
authors.initials: LZ
authors.lastname: Benet
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, USA.
authors.forename: Chelsea M
authors.initials: CM
authors.lastname: Hosey
authors.affiliation: Translational Informatics Division, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
authors.forename: Oleg
authors.initials: O
authors.lastname: Ursu
authors.affiliation: Translational Informatics Division, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
authors.forename: Tudor I
authors.initials: TI
authors.lastname: Oprea
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D001702:Biopharmaceutics; D001921:Brain / Q000378:metabolism; D016208:Databases, Factual; D006801:Humans; D007668:Kidney / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism* / Q000652:urine
chemical_list: D004364:Pharmaceutical Preparations
keywords: BCS; BDDCS; Biliary elimination; Drug-likeness; Metabolism; Renal elimination; Rule of 5