title: Paraneoplastic vasculitis associated to pelvic chondrosarcoma: a case report.
abstract: Vasculopathic syndromes have been associated with hematological and solid organ malignancies. The pathogenesis of these syndromes remains largely unknown and there are no biologic markers identified. Whether it is or is not a paraneoplastic syndrome is under discussion, the close temporal relationship of cancer and vasculitis suggests that these vasculitides are a paraneoplastic condition. We report a case of a 45-year-old female patient with pelvic chondrosarcoma who underwent surgical treatment and started to present visual loss, systemic inflammatory response syndrome (SRIS), cardiac insufficiency, hepatosplenomegaly, cholestasis as well as pulmonary bleeding suggesting a sarcoma-associated vasculitis. All antibodies were negative as in secondary vasculitis. After corticoideal therapy the vasculitis resolved and at 3-year follow-up the patient had not showed any further medical complications or recurrences of the vasculitis. The parallel evolution of the vasculitis and the solid tumor combined with the resolution of the vasculitis after corticotherapy enhances the likelihood of a paraneoplastic vasculitis associated with a chondrosarcoma according to literature review.
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, Hospital Clínico San Carlos 28 040 Madrid Spain.
authors.forename: Camilla
authors.initials: C
authors.lastname: Arvinius
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, Hospital Clínico San Carlos 28 040 Madrid Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: González-Pérez
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, Hospital Clínico San Carlos 28 040 Madrid Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: García-Coiradas
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, Hospital Clínico San Carlos 28 040 Madrid Spain.
authors.forename: Roberto
authors.initials: R
authors.lastname: García-Maroto
authors.affiliation: Department of Orthopaedic Surgery and Traumatology, Hospital Clínico San Carlos 28 040 Madrid Spain.
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Cebrián-Parra
keywords: Chondrosarcoma; Paraneoplastic; Solid tumour; Vasculitis