title: Cesium Carboxylate-Promoted Iridium Catalyzed C-H Amidation/Cyclization with 2,2,2-Trichloroethoxycarbonyl Azide.
abstract: An Ir(III)-catalyzed direct C-H amidation/cyclization of benzamides using 2,2,2-trichloroethoxycarbonyl azide (TrocN3) as the aminocarbonyl source is reported. With the aid of cesium carboxylate, the reactions proceed efficiently and with high regioselectivity, producing various functionalized quinazoline-2,4(1H,3H)-diones, which are important building blocks and key synthetic intermediates for biologically and medicinally important compounds. During the reactions, two new C-N bonds were formed by breaking C-H and N-H bonds sequence.
authors.affiliation: Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, 210093, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, 210093, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, 210093, China.
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Hu
authors.affiliation: Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, 210093, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Yu
authors.affiliation: Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, 210093, China.
authors.forename: Tianning
authors.initials: T
authors.lastname: Deng
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University , Lubbock, Texas 79409-1061, United States.
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
authors.affiliation: Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, 210093, China.
authors.forename: Hongjian
authors.initials: H
authors.lastname: Lu