title: Implications of circulating irisin and Fabp4 levels in patients with polycystic ovary syndrome.
abstract: The aim of the study was to evaluate the fatty acid-binding protein-4 (FABP4) and irisin concentrations in women with polycystic ovary syndrome (PCOS). Forty-nine women with PCOS, diagnosed according to Rotterdam criteria and 39 healthy women matched for body mass index (BMI) and age. Serum irisin and plasma FABP4 concentrations were measured in both groups. The association of irisin and FABP4 concentrations with metabolic parameters were also tested. Women with PCOS had significantly lower mean serum irisin concentrations than control subjects (158.5 ± 123.3 versus 222.9 ± 152.2 ng/ml, p < 0.05). Concentrations of FABP4 in PCOS and control groups were not significantly different (10.5 ± 4.4 versus 10.9 ± 4.2 ng/ml, p > 0.05). FABP4 concentrations were correlated with BMI, waist-hip ratio (WHR) and HOMA-IR (r = 0.57, p = 0.001; r = 0.26, p = 0.03; r = 0.26, p = 0.03, respectively). No associations between irisin and all the others parameters except serum levels of LH were found. Serum irisin concentrations of women with PCOS were lower compared to the controls. Moreover, there were no difference in plasma FABP4 concentrations between women with PCOS and controls.
authors.affiliation: a Department of Obstetrics and Gynecology , Namik Kemal University School of Medicine , Tekirdag , Turkey.
authors.forename: Remzi
authors.initials: R
authors.lastname: Abali
authors.affiliation: b Department of Obstetrics and Gynecology , Okmeydani Research and Education Hospital , Istanbul , Turkey.
authors.forename: Ilkbal
authors.initials: I
authors.lastname: Temel Yuksel
authors.affiliation: c Department of Obstetrics and Gynecology , Istanbul University Cerrahpasa School of Medicine , Istanbul , Turkey.
authors.forename: Mehmet Aytac
authors.initials: MA
authors.lastname: Yuksel
authors.affiliation: b Department of Obstetrics and Gynecology , Okmeydani Research and Education Hospital , Istanbul , Turkey.
authors.forename: Berk
authors.initials: B
authors.lastname: Bulut
authors.affiliation: c Department of Obstetrics and Gynecology , Istanbul University Cerrahpasa School of Medicine , Istanbul , Turkey.
authors.forename: Metehan
authors.initials: M
authors.lastname: Imamoglu
authors.affiliation: d Department of Obstetrics and Gynecology , Izmir University School of Medicine , Izmir , Turkey.
authors.forename: Volkan
authors.initials: V
authors.lastname: Emirdar
authors.affiliation: e Department of Obstetrics and Gynecology , Istanbul Research and Education Hospital , Istanbul , Turkey.
authors.forename: Fehmi
authors.initials: F
authors.lastname: Unal
authors.affiliation: a Department of Obstetrics and Gynecology , Namik Kemal University School of Medicine , Tekirdag , Turkey.
authors.forename: Savas
authors.initials: S
authors.lastname: Guzel
authors.affiliation: a Department of Obstetrics and Gynecology , Namik Kemal University School of Medicine , Tekirdag , Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Celik
mesh_terms: D000328:Adult; D015992:Body Mass Index; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*; D012107:Research Design; D013223:Statistics as Topic; D014421:Turkey / Q000453:epidemiology; D049629:Waist-Hip Ratio / Q000379:methods
chemical_list: C493410:FABP4 protein, human; C577593:FNDC5 protein, human; D050556:Fatty Acid-Binding Proteins; D005353:Fibronectins; D007328:Insulin; D007986:Luteinizing Hormone
keywords: FABP4; Irisin; polycystic ovary syndrome