title: Albumin correlates with all-cause mortality in elderly patients undergoing transcatheter aortic valve implantation.
abstract: OBJECTIVE
  Albumin is a marker of frailty. Scarce data are available on correlations between frailty-related parameters and outcomes in patients undergoing TAVI. This study sought to evaluate the relation between albumin and mortality in TAVI candidates.
  
  
  RESULTS
  A total of 150 patients (mean age 81±6 years) undergoing TAVI were included in the study. Patients with pre-procedural albumin >4 g/dl (>40 g/L) (n=71) were compared to those ≤4 g/dl (≤40 g/L) (n=79). The cut-off value of 4 g/dl (40 g/L) was based on the mean value of albumin in the patients included in the study. During a mean follow-up of 2.1 years the survival rate was 72%. Patients in both groups had similar baseline characteristics. The 2.1-year mortality was higher in the low albumin group compared with the normal albumin group (35% vs. 19%, p=0.01). Multivariate analysis indicated that low pre-procedural albumin was independently associated with a more than twofold increase in 2.1-year all-cause mortality (p=0.01, HR=2.28; 95% CI: 1.17-4.44). Low post-procedural serum albumin remained a strong parameter correlated with all-cause mortality (HR=2.47; 95% CI: 1.28-4.78; p<0.01).
  
  
  CONCLUSIONS
  Baseline albumin can be used as a simple tool that correlates with survival after TAVI. Low albumin is an important parameter associated with all-cause mortality after the procedure.
authors.affiliation: Leviev Heart Center, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Andrada
authors.initials: A
authors.lastname: Bogdan
authors.forename: Israel M
authors.initials: IM
authors.lastname: Barbash
authors.forename: Amit
authors.initials: A
authors.lastname: Segev
authors.forename: Paul
authors.initials: P
authors.lastname: Fefer
authors.forename: Stefan Nicolae
authors.initials: SN
authors.lastname: Bogdan
authors.forename: Elad
authors.initials: E
authors.lastname: Asher
authors.forename: Noam
authors.initials: N
authors.lastname: Fink
authors.forename: Ashraf
authors.initials: A
authors.lastname: Hamdan
authors.forename: Dan
authors.initials: D
authors.lastname: Spiegelstein
authors.forename: Ehud
authors.initials: E
authors.lastname: Raanani
authors.forename: Victor
authors.initials: V
authors.lastname: Guetta
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000601:surgery*; D002423:Cause of Death; D005260:Female; D016330:Frail Elderly; D006801:Humans; D008297:Male; D009026:Mortality; D011379:Prognosis; D012709:Serum Albumin / Q000378:metabolism*; D065467:Transcatheter Aortic Valve Replacement
chemical_list: D012709:Serum Albumin