title: Galectin-3 and prediction of therapeutic response to renal sympathetic denervation.
abstract: The profibrotic mediator Galectin-3 (Gal-3) has been associated with aldosterone-mediated vascular inflammation, fibrosis, and stiffness. We evaluated whether the Gal-3 levels and change in Gal-3 as associated with renal denervation can serve as prediction of therapeutic response to renal denervation. A total of 42 patients with resistant hypertension undergoing renal sympathetic denervation (RDN) were included. Blood pressure was evaluated by 24-h ambulatory measurement before RDN and 1, 3 and 6 months after RDN. Treatment response was defined as a drop in systolic ambulatory blood pressure of >5 mm Hg after 6 months. Blood samples were assessed for Gal-3 levels. For the entire group, a significant drop in mean systolic ambulatory blood pressure of 5.2 ± 18.6 mm Hg was observed (p = 0.032). The responder rate was 50% (n = 21). At baseline, Gal-3 levels were significantly higher in responders (14.5 ± 6.0 vs. 10.95 ± 4.6 ng/ml, p = 0.017). There were no significant changes of Gal-3 levels during the follow-up period. The profibrotic biomarker may help to identify patients suitable for RDN.
authors.affiliation: a Department of Cardiology and Angiology , Campus Mitte, Charité - Universitätsmedizin , Berlin , Germany.
authors.forename: Marius
authors.initials: M
authors.lastname: Schwerg
authors.affiliation: b Labor Berlin, Charite Vivantes Service GmbH , Berlin , Germany.
authors.forename: Björn
authors.initials: B
authors.lastname: Eilers
authors.affiliation: a Department of Cardiology and Angiology , Campus Mitte, Charité - Universitätsmedizin , Berlin , Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Wienecke
authors.affiliation: a Department of Cardiology and Angiology , Campus Mitte, Charité - Universitätsmedizin , Berlin , Germany.
authors.forename: Gert
authors.initials: G
authors.lastname: Baumann
authors.affiliation: a Department of Cardiology and Angiology , Campus Mitte, Charité - Universitätsmedizin , Berlin , Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Laule
authors.affiliation: a Department of Cardiology and Angiology , Campus Mitte, Charité - Universitätsmedizin , Berlin , Germany.
authors.forename: Fabian
authors.initials: F
authors.lastname: Knebel
authors.affiliation: a Department of Cardiology and Angiology , Campus Mitte, Charité - Universitätsmedizin , Berlin , Germany.
authors.forename: Karl
authors.initials: K
authors.lastname: Stangl
authors.affiliation: a Department of Cardiology and Angiology , Campus Mitte, Charité - Universitätsmedizin , Berlin , Germany.
authors.forename: Verena
authors.initials: V
authors.lastname: Stangl
mesh_terms: D000368:Aged; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D005260:Female; D037502:Galectin 3 / Q000032:analysis / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery; D007668:Kidney / Q000294:innervation*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011379:Prognosis; D012008:Recurrence; D013562:Sympathectomy / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome
chemical_list: D037502:Galectin 3
keywords: Galectin-3; renal denervation; resistant arterial hypertension