title: bcTol : a highly water-soluble biradical for efficient dynamic nuclear polarization of biomolecules.
abstract: Dynamic nuclear polarization (DNP) is an efficient method to overcome the inherent low sensitivity of magic-angle spinning (MAS) solid-state NMR. We report a new polarizing agent (), designed for biological applications, that yielded an enhancement value of 244 in a microcrystalline SH3 domain sample at 110 K.
authors.affiliation: University of Iceland, Department of Chemistry, Science Institute, Dunhaga 3, 107 Reykjavik, Iceland. snorrisi@hi.is.
authors.forename: Anil P
authors.initials: AP
authors.lastname: Jagtap
authors.affiliation: NMR supported structural biology, Leibniz-Institut for Molecular Biology (FMP), Robert-Roessle-Str. 10, 13125 Berlin, Germany. oschkinat@fmp-berlin.de.
authors.forename: Michel-Andreas
authors.initials: MA
authors.lastname: Geiger
authors.affiliation: NMR supported structural biology, Leibniz-Institut for Molecular Biology (FMP), Robert-Roessle-Str. 10, 13125 Berlin, Germany. oschkinat@fmp-berlin.de.
authors.forename: Daniel
authors.initials: D
authors.lastname: Stöppler
authors.affiliation: NMR supported structural biology, Leibniz-Institut for Molecular Biology (FMP), Robert-Roessle-Str. 10, 13125 Berlin, Germany. oschkinat@fmp-berlin.de.
authors.forename: Marcella
authors.initials: M
authors.lastname: Orwick-Rydmark
authors.affiliation: NMR supported structural biology, Leibniz-Institut for Molecular Biology (FMP), Robert-Roessle-Str. 10, 13125 Berlin, Germany. oschkinat@fmp-berlin.de.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Oschkinat
authors.affiliation: University of Iceland, Department of Chemistry, Science Institute, Dunhaga 3, 107 Reykjavik, Iceland. snorrisi@hi.is.
authors.forename: Snorri Th
authors.initials: ST
authors.lastname: Sigurdsson
mesh_terms: D000075402:Channelrhodopsins / Q000737:chemistry*; D005609:Free Radicals / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011392:Proline / Q000737:chemistry*; D059629:Signal-To-Noise Ratio; D012995:Solubility; D013049:Spectrin / Q000737:chemistry*; D013696:Temperature; D018909:src Homology Domains
chemical_list: D000075402:Channelrhodopsins; D005609:Free Radicals; D013049:Spectrin; D011392:Proline