title: 1,3,2-Diazaphospholidine (N-Heterocyclic Phosphine)-Mediated Carbon-Phosphorus Bond-Forming, One-Pot Tandem Reaction: A Route to α-Amino Phosphonates.
abstract: A novel 1,3,2-diazaphospholidine (N-heterocyclic phosphine)-thiourea-mediated phospha-Mannich/intramolecular nucleophilic substitution reaction has been developed for the construction of an N-C-P bond unit. This transformation enabled a rapid access to cyclic tertiary α-amino phosphonates in one-pot procedure under additive-free mild reaction conditions. This study revealed the critical role of thiourea moiety of the N-heterocyclic phosphine-thiourea in the sequential intramolecular nucleophilic substitution reaction of the phosphonylation.
authors.affiliation: Department of Chemistry and Biochemistry, University of Nevada Las Vegas , 4505 S. Maryland Parkway, Las Vegas, Nevada 89154-4003, United States.
authors.forename: Karimulla
authors.initials: K
authors.lastname: Mulla
authors.affiliation: Department of Chemistry and Biochemistry, University of Nevada Las Vegas , 4505 S. Maryland Parkway, Las Vegas, Nevada 89154-4003, United States.
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Kang