title: Effect of Slow Wave Sleep Disruption on Metabolic Parameters in Adolescents.
abstract: Cross-sectional studies report a correlation between slow wave sleep (SWS) duration and insulin sensitivity (SI) in children and adults. Suppression of SWS causes insulin resistance in adults but effects in children are unknown. This study was designed to determine the effect of SWS fragmentation on SI in children.
  
  
  
  Fourteen pubertal children (11.3-14.1 y, body mass index 29(th) to 97(th) percentile) were randomized to sleep studies and mixed meal (MM) tolerance tests with and without SWS disruption. Beta-cell responsiveness (Φ) and SI were determined using oral minimal modeling.
  
  
  
  During the disruption night, auditory stimuli (68.1 ± 10.7/night; mean ± standard error) decreased SWS by 40.0 ± 8.0%. SWS fragmentation did not affect fasting glucose (non-disrupted 76.9 ± 2.3 versus disrupted 80.6 ± 2.1 mg/dL), insulin (9.2 ± 1.6 versus 10.4 ± 2.0 μIU/mL), or C-peptide (1.9 ± 0.2 versus 1.9 ± 0.1 ng/mL) levels and did not impair SI (12.9 ± 2.3 versus 10.1 ± 1.6 10(-4) dL/kg/min per μIU/mL) or Φ (73.4 ± 7.8 versus 74.4 ± 8.4 10(-9) min(-1)) to a MM challenge. Only the subjects in the most insulin-sensitive tertile demonstrated a consistent decrease in SI after SWS disruption.
  
  
  
  Pubertal children across a range of body mass indices may be resistant to the adverse metabolic effects of acute SWS disruption. Only those subjects with high SI (i.e., having the greatest "metabolic reserve") demonstrated a consistent decrease in SI. These results suggest that adolescents may have a unique ability to adapt to metabolic stressors, such as acute SWS disruption, to maintain euglycemia. Additional studies are necessary to confirm that this resiliency is maintained in settings of chronic SWS disruption.
authors.affiliation: Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.|Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC.
authors.forename: Natalie D
authors.initials: ND
authors.lastname: Shaw
authors.affiliation: Division of Sleep and Circadian Disorders, The Brigham and Women's Hospital, Boston MA.|Division of Sleep Medicine, Harvard Medical School, Boston MA.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: McHill
authors.affiliation: Department of Information Engineering, University of Padova, Padova, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Schiavon
authors.affiliation: Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.
authors.forename: Tairmae
authors.initials: T
authors.lastname: Kangarloo
authors.affiliation: Division of Sleep and Circadian Disorders, The Brigham and Women's Hospital, Boston MA.|Division of Sleep Medicine, Harvard Medical School, Boston MA.
authors.forename: Piotr W
authors.initials: PW
authors.lastname: Mankowski
authors.affiliation: Department of Information Engineering, University of Padova, Padova, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Cobelli
authors.affiliation: Division of Sleep and Circadian Disorders, The Brigham and Women's Hospital, Boston MA.|Division of Sleep Medicine, Harvard Medical School, Boston MA.
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: Klerman
authors.affiliation: Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.|Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC.
authors.forename: Janet E
authors.initials: JE
authors.lastname: Hall
mesh_terms: D000293:Adolescent; D002648:Child; D003430:Cross-Sectional Studies; D005215:Fasting / Q000097:blood / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000032:analysis / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance; D008297:Male; D017286:Polysomnography; D012890:Sleep; D012893:Sleep Wake Disorders / Q000097:blood / Q000378:metabolism*
chemical_list: D007328:Insulin; D005947:Glucose
keywords: glucose; insulin; puberty; slow wave sleep