title: Impact of hematogones on the long-term outcomes of single-unit cord blood transplantation for adult patients.
abstract: Hematogones are normal B-lymphocyte precursors identified in the regenerative state of the bone marrow following allogeneic hematopoietic stem cell transplantation (HSCT). To evaluate the impact of hematogones on long-term outcomes after single-unit cord blood transplantation (CBT), we retrospectively analyzed 134 adult patients at our institute. At the median time of 41 days (range, 20 to 77 days) after CBT, the median proportion of morphological hematogones in bone marrow was found to be 2.4% (range, 0 to 13.0%). In the patients with standard-risk, the higher proportion of morphological hematogones was associated with lower transplant-related mortality (TRM) after CBT. The proportion of hematogones did not affect the subsequent absolute lymphocyte counts in the peripheral blood and serum immunoglobulin G levels six months later after CBT. These data shows that morphological hematogones in the routine bone marrow analysis might be a practical and easily evaluable method of predicting outcomes after CBT.
authors.affiliation: a Department of Hematology/Oncology , The Institute of Medical Science, The University of Tokyo , Tokyo , Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Ishii
authors.affiliation: a Department of Hematology/Oncology , The Institute of Medical Science, The University of Tokyo , Tokyo , Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Konuma
authors.affiliation: a Department of Hematology/Oncology , The Institute of Medical Science, The University of Tokyo , Tokyo , Japan.
authors.forename: Seiko
authors.initials: S
authors.lastname: Kato
authors.affiliation: a Department of Hematology/Oncology , The Institute of Medical Science, The University of Tokyo , Tokyo , Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Oiwa-Monna
authors.affiliation: a Department of Hematology/Oncology , The Institute of Medical Science, The University of Tokyo , Tokyo , Japan.
authors.forename: Arinobu
authors.initials: A
authors.lastname: Tojo
authors.affiliation: a Department of Hematology/Oncology , The Institute of Medical Science, The University of Tokyo , Tokyo , Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D003131:Combined Modality Therapy; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods; D005260:Female; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D006801:Humans; D007109:Immunity; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D009026:Mortality; D010641:Phenotype; D054448:Precursor Cells, B-Lymphoid / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D012008:Recurrence; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: B-lymphocyte; cord blood transplantation; hematogones; hematopoietic stem cell transplantation; immune reconstitution; transplant-related mortality