title: Little fish, big catch: zebrafish as a model for kidney disease.
abstract: The zebrafish, Danio rerio, is a relevant vertebrate model for biomedical research and translational studies because of its broad genetic conservation with humans. In recent years, scientists have formulated a growing list of zebrafish kidney disease paradigms, the study of which has contributed a multitude of insights into the basic biology of human conditions and even identified potential therapeutic agents. Conversely, there are also distinctive aspects of zebrafish biology lacking in higher vertebrates, such as the capacity to heal without lasting scar formation after tissue damage and the ability to generate nephrons throughout their lifespan, which makes the zebrafish uniquely suited to study regeneration in the context of the kidney. Here, we review several informative zebrafish models of kidney disease and discuss their future applications in nephrology.
authors.affiliation: Department of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, University of Notre Dame, Notre Dame, Indiana, USA.
authors.forename: Shahram Jevin
authors.initials: SJ
authors.lastname: Poureetezadi
authors.affiliation: Department of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, University of Notre Dame, Notre Dame, Indiana, USA. Electronic address: rwingert@nd.edu.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Wingert
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000473:pathology* / Q000628:therapy; D000818:Animals; D004195:Disease Models, Animal; D005921:Glomerulonephritis / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D009399:Nephrons / Q000196:embryology / Q000473:pathology*; D038081:Organogenesis; D012038:Regeneration; D015027:Zebrafish / Q000502:physiology*
keywords: acute kidney injury; glomerulus; nephrotoxity; renal pathology; stem cell