title: STAT4 confers risk for rheumatoid arthritis and systemic lupus erythematosus in Mexican patients.
abstract: STAT4 has been consistently associated with several autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The aim of this study was to determine whether the STAT4 rs7574865G/T polymorphism confers susceptibility for RA and SLE in a sample of Mexican patients. This study included 869 individuals: 415 patients with RA, 128 patients with SLE, and 326 controls. Genotyping using TaqMan probes showed an association between the STAT4 rs7574865G/T polymorphism and RA (GG vs. TT: OR 1.99, p=0.0009; G vs. T: OR 1.42, p=0.0009) and SLE (GG vs. TT: OR 2.98, 0.0003; G vs. T: OR 1.74, p=0.0002). Gender stratification showed an association with RA (GG vs. TT: OR 1.99, 95% CI 1.3-3.1, p=0.002; G vs. T: OR 1.42, 95% CI 1.1-1.8, p=0.002) and SLE (GG vs. TT: OR 3.3, 95% CI 1.7-6.2, p=0.0002; G vs. T: OR 1.8, 95% CI 1.3-2.4, p=0.0002) in women. Thus, the STAT4 rs7574865G/T polymorphism confers risk for RA and SLE in the Mexican population.
authors.affiliation: Research Unit in Endocrine and Metabolic Diseases, Hospital Juárez de México, Mexico City, Mexico.
authors.forename: O
authors.initials: O
authors.lastname: Beltrán Ramírez
authors.affiliation: Laboratorio de Oncología Molecular, Unidad de Diferenciación Celular y Cáncer, FES-Zaragoza, UNAM, Mexico City, Mexico.
authors.forename: J F
authors.initials: JF
authors.lastname: Mendoza Rincón
authors.affiliation: Rheumatology Department, Hospital Juárez de México, Mexico City, Mexico.
authors.forename: R E
authors.initials: RE
authors.lastname: Barbosa Cobos
authors.affiliation: Research Unit in Endocrine and Metabolic Diseases, Hospital Juárez de México, Mexico City, Mexico.
authors.forename: I
authors.initials: I
authors.lastname: Alemán Ávila
authors.affiliation: Research Unit in Endocrine and Metabolic Diseases, Hospital Juárez de México, Mexico City, Mexico. Electronic address: dr.julian.ramirez.hjm@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Ramírez Bello
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D050797:STAT4 Transcription Factor / Q000235:genetics*; D012737:Sex Factors
chemical_list: D050797:STAT4 Transcription Factor; C494090:STAT4 protein, human
keywords: Polymorphisms; Rheumatoid arthritis; STAT4; Systemic lupus erythematosus