title: Quantitative Determination of Catechin as Chemical Marker in Pediatric Polyherbal Syrup by HPLC/DAD.
abstract: Vivabon syrup is a balanced composition of dietary ingredients of phytopharmaceutical nature for maintaining the physique, vigor, vitality and balanced growth of children. The herbal ingredients of pediatric syrup are rich in bioflavonoid, proteins, vitamins, glycosides and trace elements. Vivabon is formulated with herbal drugs such as Phoenix sylvestris, Emblica officinalis, Withania somnifera, Centella asiatica, Amomum subulatum, Zingiber officinalis, Trigonella foenum-graecum, Centaurea behen and Piper longum Catechins are flavan-3-ols that are found widely in the medicinal herbs and are utilized for anti-inflammatory, cardio protective, hepato-protective, neural protection and other biological activities. In general, the dietary intake of flavonoids has been regarded traditionally as beneficial for body growth. Standardization of Vivabon syrup dosage form using HPLC/DAD has been developed for quantitative estimation of Catechin as a chemical marker. The method was validated as per ICH guidelines. Validation studies demonstrated that the developed HPLC method is quite distinct, reproducible as well as quick and fast. The relatively high recovery and low comparable standard deviation confirm the suitability of the developed method for the determination of Catechin in syrup.
authors.affiliation: Research and Development Department, Herbion Pakistan (Pvt.) Limited, Plot 30, Sector 28, Korangi industrial Area, Karachi 74900, Pakistan.
authors.forename: Zeeshan A
authors.initials: ZA
authors.lastname: Sheikh
authors.affiliation: Research and Development Department, Herbion Pakistan (Pvt.) Limited, Plot 30, Sector 28, Korangi industrial Area, Karachi 74900, Pakistan.
authors.forename: Zafar A
authors.initials: ZA
authors.lastname: Siddiqui
authors.affiliation: Department of Clinical Pharmacy and Health Care, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan safila117@yahoo.com.
authors.forename: Safila
authors.initials: S
authors.lastname: Naveed
authors.affiliation: Research and Development Department, Herbion Pakistan (Pvt.) Limited, Plot 30, Sector 28, Korangi industrial Area, Karachi 74900, Pakistan Department of Clinical Pharmacy and Health Care, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan.
authors.forename: Khan
authors.initials: K
authors.lastname: Usmanghani
mesh_terms: D002392:Catechin / Q000032:analysis*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D028321:Plant Preparations / Q000737:chemistry*
chemical_list: D028321:Plant Preparations; D002392:Catechin