title: Vanished Twins and Misdiagnosed Sex: A Case Report with Implications in Prenatal Counseling Using Noninvasive Cell-Free DNA Screening.
abstract: Cell-free DNA testing is a recently introduced method for screening pregnant women for fetal trisomy, which is associated with some common significant genetic diseases, as well as the sex of the fetus. The case described here demonstrates the connection between the ultrasound "vanishing twin" phenomenon and the misdiagnosis of prenatal sex using cell-free DNA testing.
authors.affiliation: From The Department of Family Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA. jkelley2@hmc.psu.edu.
authors.forename: James F
authors.initials: JF
authors.lastname: Kelley
authors.affiliation: From The Department of Family Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA.
authors.forename: George
authors.initials: G
authors.lastname: Henning
authors.affiliation: From The Department of Family Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Ambrose
authors.affiliation: From The Department of Family Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA.
authors.forename: Alan
authors.initials: A
authors.lastname: Adelman
mesh_terms: D013734:Androgen-Insensitivity Syndrome / Q000175:diagnosis* / Q000235:genetics; D000782:Aneuploidy; D004247:DNA / Q000302:isolation & purification; D003951:Diagnostic Errors; D005260:Female; D005327:Fetal Resorption / Q000000981:diagnostic imaging*; D005333:Fetus; D005817:Genetic Counseling / Q000379:methods*; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D008297:Male; D011247:Pregnancy; D059285:Pregnancy, Twin / Q000097:blood; D011296:Prenatal Diagnosis / Q000379:methods*; D017422:Sequence Analysis, DNA; D012730:Sex Chromosomes; D014314:Trisomy / Q000175:diagnosis / Q000235:genetics; D016216:Ultrasonography, Prenatal; D014592:Uterine Hemorrhage
chemical_list: D004247:DNA
keywords: Case Reports; Genetics; Obstetrics; Prenatal Care