title: Application of Novel Software Algorithms to Spectral-Domain Optical Coherence Tomography for Automated Detection of Diabetic Retinopathy.
abstract: To present novel software algorithms applied to spectral-domain optical coherence tomography (SD-OCT) for automated detection of diabetic retinopathy (DR).
  
  
  
  Thirty-one diabetic patients (44 eyes) and 18 healthy, nondiabetic controls (20 eyes) who underwent volumetric SD-OCT imaging and fundus photography were retrospectively identified. A retina specialist independently graded DR stage. Trained automated software generated a retinal thickness score signifying macular edema and a cluster score signifying microaneurysms and/or hard exudates for each volumetric SD-OCT.
  
  
  
  Of 44 diabetic eyes, 38 had DR and six eyes did not have DR. Leave-one-out cross-validation using a linear discriminant at missed detection/false alarm ratio of 3.00 computed software sensitivity and specificity of 92% and 69%, respectively, for DR detection when compared to clinical assessment.
  
  
  
  Novel software algorithms applied to commercially available SD-OCT can successfully detect DR and may have potential as a viable screening tool for DR in future. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:410-417.].
authors.forename: Mehreen
authors.initials: M
authors.lastname: Adhi
authors.forename: Salim K
authors.initials: SK
authors.lastname: Semy
authors.forename: David W
authors.initials: DW
authors.lastname: Stein
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Potter
authors.forename: Walter S
authors.initials: WS
authors.lastname: Kuklinski
authors.forename: Harry A
authors.initials: HA
authors.lastname: Sleeper
authors.forename: Jay S
authors.initials: JS
authors.lastname: Duker
authors.forename: Nadia K
authors.initials: NK
authors.lastname: Waheed
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001331:Automation; D003930:Diabetic Retinopathy / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012160:Retina; D012189:Retrospective Studies; D012984:Software; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity / Q000502:physiology*; D055815:Young Adult