title: Malignant phyllodes tumor in an 11-year-old girl with fatal clinical outcome. A case report.
abstract: BACKGROUND
  Phyllodes tumors are rare biphasic tumors occur predominantly in middle aged women. Malignant phyllodes tumor in children is very rare.
  
  
  OBJECTIVE
  To report a case of malignant phyllodes tumor in a pre-menarchal girl.
  
  
  METHODS
  H&E slides of the case were reviewed and follow up was obtained.
  
  
  RESULTS
  The patient was 11-year-old girl who noticed a lump in her right breast 1 year back which grew rapidly in size. Wide local excision of the mass was done and histopathology revealed a malignant phyllodes tumor. Patient underwent mastectomy one month later due to recurrence. Two years later, she presented with dyspnea and chest pain. CT showed lung metastasis. The patient died of disease 1 year later due to widespread metastasis in liver and bone.
  
  
  CONCLUSIONS
  We report a case of malignant phyllodes tumor in an 11-year-old girl, which behaved aggressively and patient died of disease due to widespread metastases 3 years after diagnosis.
authors.affiliation: Aga Khan Medical School, Stadium Road Karachi, Pakistan.
authors.forename: Sidra
authors.initials: S
authors.lastname: Hassan
authors.affiliation: Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.
authors.forename: Nasir
authors.initials: N
authors.lastname: Ud Din
authors.affiliation: Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.
authors.forename: Naila
authors.initials: N
authors.lastname: Kayani
mesh_terms: D001859:Bone Neoplasms / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D002648:Child; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008408:Mastectomy; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D003557:Phyllodes Tumor / Q000556:secondary / Q000601:surgery*
keywords: Breast; malignant phyllodes tumor; phyllodes tumor; pre-menarchal girl