title: Analysis of the association of VIPR2 polymorphisms with susceptibility to schizophrenia.
abstract: In a previous study, we confirmed that copy number variants (CNVs) within the VIPR2 gene in Han Chinese individuals exhibit an increased risk of schizophrenia (SCZ). Herein, we further analyzed the association of eight tagged single nucleotide polymorphisms (tagSNPs) from the HapMap database with SCZ susceptibility. However, we found no significant positive signals in overall association and haplotypes analyses. Interestingly, significant SNP-SNP interaction signals associated with the risk of SCZ were observed using Multifactor Dimensionality Reduction (MDR) analysis. Furthermore, the 'CC' genotype of the VIPR2 gene was nominally associated with an increased risk of SCZ in male patients.
authors.affiliation: Wuxi Mental Health Center, Nanjing Medical University, Wuxi 214151, Jiangsu Province, PR China; Jiangsu Institute of Psychology, Wuxi 214151, Jiangsu Province, PR China. Electronic address: jch1029@126.com.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Jin
authors.affiliation: Wuxi Mental Health Center, Nanjing Medical University, Wuxi 214151, Jiangsu Province, PR China.
authors.forename: Zhenhe
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200040, PR China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Li
authors.affiliation: Wuxi Mental Health Center, Nanjing Medical University, Wuxi 214151, Jiangsu Province, PR China.
authors.forename: Fuquan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Wuxi Mental Health Center, Nanjing Medical University, Wuxi 214151, Jiangsu Province, PR China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Wuxi Mental Health Center, Nanjing Medical University, Wuxi 214151, Jiangsu Province, PR China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Liu
authors.affiliation: Wuxi Mental Health Center, Nanjing Medical University, Wuxi 214151, Jiangsu Province, PR China. Electronic address: chengzaohuo@126.com.
authors.forename: Zaohuo
authors.initials: Z
authors.lastname: Cheng
mesh_terms: D000328:Adult; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D051239:Receptors, Vasoactive Intestinal Peptide, Type II / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D051239:Receptors, Vasoactive Intestinal Peptide, Type II; C495509:VIPR2 protein, human
keywords: Han Chinese; Schizophrenia; VIPR2