title: Low-fidelity alternative DNA repair carcinogenesis theory may interpret many cancer features and anticancer strategies.
abstract: We have proposed that the low-fidelity compensatory backup alternative DNA repair pathways drive multistep carcinogenesis. Here, we apply it to interpret the clinical features of cancer, such as mutator phenotype, tissue specificity, age specificity, diverse types of cancers originated from the same type of tissue, cancer susceptibility of patients with DNA repair-defective syndromes, development of cancer only for a selected number of individuals among those that share the same genetic defect, invasion and metastasis. Clinically, the theory predicts that to improve the efficacy of molecular targeted or synthetic lethal therapy, it may be crucial to inhibit the low-fidelity compensatory alternative DNA repair either directly or by blocking the signal transducers of the sustained microenvironmental stress.
authors.affiliation: School of Life Sciences, Shanghai University, 99 Shangda Road, Shanghai 200444, China.|Central Laboratories, Xuhui Central Hospital, Shanghai Clinical Center, Chinese Academy of Sciences, 966 Middle Huaihai Road, Shanghai 200031, China.
authors.forename: Chuo
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Pathology & Laboratory Medicine, Brody School of Medicine, East Carolina University, 600 Moye Boulevard, Greenville, North Carolina 27834, USA and currently Flint Medical Laboratory, 3490 Calkins Road, Flint, MI 48532, USA.
authors.forename: Shane
authors.initials: S
authors.lastname: Starr
authors.affiliation: School of Life Sciences, Shanghai University, 99 Shangda Road, Shanghai 200444, China.
authors.forename: Fuxue
authors.initials: F
authors.lastname: Chen
authors.affiliation: Central Laboratories, Xuhui Central Hospital, Shanghai Clinical Center, Chinese Academy of Sciences, 966 Middle Huaihai Road, Shanghai 200031, China.|Department of Pathology & Laboratory Medicine, Brody School of Medicine, East Carolina University, 600 Moye Boulevard, Greenville, North Carolina 27834, USA and currently Flint Medical Laboratory, 3490 Calkins Road, Flint, MI 48532, USA.
authors.forename: Jiaxi
authors.initials: J
authors.lastname: Wu
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics*
keywords: alternative DNA repair; carcinogenesis; synthetic lethality