title: Post-synthetic modification of an amino-functionalized metal-organic framework for highly efficient enrichment of N-linked glycopeptides.
abstract: A maltose-functionalized metal-organic framework (MOF), MIL-101(Cr)-maltose, was developed via a simple two step post-synthetic modification of MIL-101(Cr)-NH2. With the use of this nanomaterial, 33 glycopeptides were detected from the digest of human immunoglobulin G, demonstrating its high efficiency in glycoproteomic analysis. More importantly, the generic functionalization route from amino-derived MOFs opens a new perspective in material design in sample preparation.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. yu.bai@pku.edu.cn.
authors.forename: Wen
authors.initials: W
authors.lastname: Ma
authors.forename: Linnan
authors.initials: L
authors.lastname: Xu
authors.forename: Ze
authors.initials: Z
authors.lastname: Li
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Sun
authors.forename: Yu
authors.initials: Y
authors.lastname: Bai
authors.forename: Huwei
authors.initials: H
authors.lastname: Liu
mesh_terms: D006020:Glycopeptides / Q000737:chemistry*; D006801:Humans; D007074:Immunoglobulin G / Q000737:chemistry; D000073396:Metal-Organic Frameworks / Q000737:chemistry*; D049329:Nanostructures
chemical_list: D006020:Glycopeptides; D007074:Immunoglobulin G; D000073396:Metal-Organic Frameworks