title: Carbohydrate-induced secretion of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1.
abstract: Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are the incretin hormones secreted from enteroendocrine K-cells and L-cells, respectively, by oral ingestion of various nutrients including glucose. K-cells, L-cells and pancreatic β-cells are glucose-responsive cells with similar glucose-sensing machinery including glucokinase and an adenosine triphosphate-sensitive K(+) channel comprising KIR6.2 and sulfonylurea receptor 1. However, the physiological role of the adenosine triphosphate-sensitive K(+) channel in GIP secretion in K-cells and GLP-1 secretion in L-cells is not elucidated. Recently, it was reported that GIP and GLP-1-producing cells are present also in pancreatic islets, and islet-derived GIP and GLP-1 contribute to glucose-induced insulin secretion from pancreatic β-cells. In this short review, we focus on GIP and GLP-1 secretion by monosaccharides, such as glucose or fructose, and the role of the adenosine triphosphate-sensitive K(+) channel in GIP and GLP-1 secretion.
authors.affiliation: Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine Nagoya Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Seino
authors.affiliation: Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine Nagoya Japan.
authors.forename: Ryuya
authors.initials: R
authors.lastname: Maekawa
authors.affiliation: Department of Endocrinology and Diabetes Nagoya University Graduate School of Medicine Nagoya Japan.
authors.forename: Hidetada
authors.initials: H
authors.lastname: Ogata
authors.affiliation: Department of Genetics, Division of Stress Adaptation and Recognition, Research Institute of Environmental Medicine Nagoya University Nagoya Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D000818:Animals; D004040:Dietary Carbohydrates / Q000378:metabolism*; D019858:Enteroendocrine Cells / Q000378:metabolism*; D005632:Fructose / Q000378:metabolism*; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D051296:Glucose Transporter Type 5; D006801:Humans; D054795:Incretins / Q000378:metabolism; D007515:Islets of Langerhans / Q000378:metabolism; D054086:KATP Channels / Q000378:metabolism; D051379:Mice; D051269:Sodium-Glucose Transporter 1 / Q000378:metabolism
chemical_list: D004040:Dietary Carbohydrates; D051296:Glucose Transporter Type 5; D054795:Incretins; D054086:KATP Channels; D051269:Sodium-Glucose Transporter 1; D005632:Fructose; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1; D005947:Glucose
keywords: Carbohydrates; Glucagon‐like peptide‐1; Glucose‐dependent insulinotropic polypeptide