title: New insights into basophil heterogeneity.
abstract: Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.
authors.affiliation: Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8123, St. Louis, MO, 63110, USA.|Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, USA.|Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Landon K
authors.initials: LK
authors.lastname: Oetjen
authors.affiliation: Division of Experimental Pathology, Institute of Pathology, University of Bern, Bern, Switzerland.
authors.forename: Mario
authors.initials: M
authors.lastname: Noti
authors.affiliation: Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8123, St. Louis, MO, 63110, USA. briankim@wustl.edu.|Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, USA. briankim@wustl.edu.|Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA. briankim@wustl.edu.|Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. briankim@wustl.edu.|Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA. briankim@wustl.edu.
authors.forename: Brian S
authors.initials: BS
authors.lastname: Kim
mesh_terms: D000818:Animals; D001491:Basophils / Q000166:cytology* / Q000502:physiology*; D001854:Bone Marrow Cells / Q000166:cytology / Q000378:metabolism; D002450:Cell Communication / Q000235:genetics / Q000276:immunology; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D004198:Disease Susceptibility; D005110:Extracellular Space / Q000378:metabolism; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology / Q000378:metabolism; D007377:Interleukin-3 / Q000378:metabolism; D042541:Intracellular Space / Q000378:metabolism; D015398:Signal Transduction; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D016207:Cytokines; D007377:Interleukin-3; D007073:Immunoglobulin E; D000094632:Thymic Stromal Lymphopoietin