title: Low frontal serotonin 2A receptor binding is a state marker for schizophrenia?
abstract: Here we imaged serotonin 2A receptor (5-HT2AR) binding in a very rare population of monozygotic twins discordant for schizophrenia to provide insight into trait and state components in brain 5-HT2AR patterns. In four twin pairs not medicated with drugs that target 5-HT2AR, frontal 5-HT2AR binding was consistently lower (33%) in schizophrenic- relative to their healthy co-twins. Our results strongly imply low frontal 5-HT2AR availability as a state feature of schizophrenia. If replicated, ideally in a larger sample also including dizygotic twin pairs and drug-naïve patients, this finding critically advance our understanding of the complex pathophysiology of schizophrenia.
authors.affiliation: Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Faculty of Health Sciences, Psychiatric Center Glostrup, Copenhagen University Hospital Glostrup, Denmark.
authors.forename: Hans
authors.initials: H
authors.lastname: Rasmussen
authors.affiliation: Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Rigshospitalet, University of Copenhagen, Denmark. Electronic address: vibe@nru.dk.
authors.forename: Vibe G
authors.initials: VG
authors.lastname: Frokjaer
authors.affiliation: Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Faculty of Health Sciences, Psychiatric Center Glostrup, Copenhagen University Hospital Glostrup, Denmark.
authors.forename: Rikke W
authors.initials: RW
authors.lastname: Hilker
authors.affiliation: PET and Cyclotron Unit, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: Jacob
authors.initials: J
authors.lastname: Madsen
authors.affiliation: Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Faculty of Health Sciences, Psychiatric Center Glostrup, Copenhagen University Hospital Glostrup, Denmark.
authors.forename: Simon
authors.initials: S
authors.lastname: Anhøj
authors.affiliation: Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Faculty of Health Sciences, Psychiatric Center Glostrup, Copenhagen University Hospital Glostrup, Denmark.
authors.forename: Bob
authors.initials: B
authors.lastname: Oranje
authors.affiliation: Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: Lars H
authors.initials: LH
authors.lastname: Pinborg
authors.affiliation: Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Faculty of Health Sciences, Psychiatric Center Glostrup, Copenhagen University Hospital Glostrup, Denmark.
authors.forename: Birte
authors.initials: B
authors.lastname: Glenthøj
authors.affiliation: Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: Gitte M
authors.initials: GM
authors.lastname: Knudsen
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D005260:Female; D005462:Fluorine Radioisotopes; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D007650:Ketanserin / Q000031:analogs & derivatives; D008297:Male; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D014430:Twins, Monozygotic; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D044402:Receptor, Serotonin, 5-HT2A; C071983:altanserin; D007650:Ketanserin; C000615276:Fluorine-18