title: SNCA Gene Polymorphism may Contribute to an Increased Risk of Alzheimer's Disease.
abstract: BACKGROUND
  The purpose of this study is to elucidate the association between α-synuclein (SNCA) polymorphisms and the risk of Alzheimer's disease (AD).
  
  
  METHODS
  The PCR-RFLP was applied to detect SNCA gene rs6532190, rs3775430, and rs10516846 polymorphisms in 98 AD patients and 105 healthy elderly.
  
  
  RESULTS
  The GG frequency of rs10516846 was evidently increased in AD group than control group (P < 0.05). There was a significant difference in SNCA level between the AD and control groups (P < 0.01). In the AD group, the SNCA level in cerebrospinal fluid of GG (rs10516846) carriers was increased as compared with AA carriers (P < 0.05). The GG (rs10516846) frequency of the early-onset AD group is significantly higher than that of the late-onset AD group (P < 0.05). The frequency of rs3775430 GG was lower in the early-onset group than that in the late-onset group (0% vs. 16.7%). The SNCA level in cerebrospinal fluid of GG (rs10516846) carriers in the early-onset AD group is higher than that of AA carriers (P < 0.05).
  
  
  CONCLUSIONS
  SNCA gene polymorphism may be associated with an increased risk of AD and GG genotype of rs10516846 and elevated SNCA level in CSF may increase the risk of early-onset AD.
authors.affiliation: Department of Neurology, Linyi People's Hospital, Linyi, Shandong Province, China.
authors.forename: Quanbao
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Neurology, Linyi People's Hospital, Linyi, Shandong Province, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Tian
authors.affiliation: Department of Neurology, Linyi People's Hospital, Linyi, Shandong Province, China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Neurology, Linyi People's Hospital, Linyi, Shandong Province, China.
authors.forename: Yunyong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Neurology, Linyi People's Hospital, Linyi, Shandong Province, China. liwei_lwlw@yeah.net.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D051843:Synucleins / Q000134:cerebrospinal fluid / Q000235:genetics*
chemical_list: D051843:Synucleins
keywords: 
  SNCA
  ; Alzheimer's disease; Polymorphism; Risk; rs10516846