title: Recent advances in SCF ubiquitin ligase complex: Clinical implications.
abstract: F-box proteins, which are subunit recruiting modules of SCF (SKP1-Cullin 1-F-box protein) E3 ligase complexes, play critical roles in the development and progression of human malignancies through governing multiple cellular processes including cell proliferation, apoptosis, invasion and metastasis. Moreover, there are emerging studies that lead to the development of F-box proteins inhibitors with promising therapeutic potential. In this article, we describe how F-box proteins including but not restricted to well-established Fbw7, Skp2 and β-TRCP, are involved in tumorigenesis. However, in-depth investigation is required to further explore the mechanism and the physiological contribution of undetermined F-box proteins in carcinogenesis. Lastly, we suggest that targeting F-box proteins could possibly open new avenues for the treatment and prevention of human cancers.
authors.affiliation: The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215123, China.
authors.forename: Nana
authors.initials: N
authors.lastname: Zheng
authors.affiliation: The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215123, China.
authors.forename: Quansheng
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215123, China; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA 02215, USA. Electronic address: zhiweichina@126.com.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA 02215, USA. Electronic address: wwei2@bidmc.harvard.edu.
authors.forename: Wenyi
authors.initials: W
authors.lastname: Wei
mesh_terms: D017209:Apoptosis / Q000235:genetics; D063646:Carcinogenesis / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D044783:F-Box Proteins / Q000235:genetics* / Q000378:metabolism; D000073979:F-Box-WD Repeat-Containing Protein 7; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness / Q000235:genetics; D009362:Neoplasm Metastasis; D064129:Prostatic Neoplasms, Castration-Resistant / Q000235:genetics* / Q000473:pathology; D044786:S-Phase Kinase-Associated Proteins / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000235:genetics; D044844:beta-Transducin Repeat-Containing Proteins / Q000235:genetics
chemical_list: C471644:BTRC protein, human; D018797:Cell Cycle Proteins; D044783:F-Box Proteins; D000073979:F-Box-WD Repeat-Containing Protein 7; C507917:FBXO31 protein, human; C513273:FBXW7 protein, human; D044786:S-Phase Kinase-Associated Proteins; D025521:Tumor Suppressor Proteins; D044844:beta-Transducin Repeat-Containing Proteins; D044767:Ubiquitin-Protein Ligases
keywords: F-box protein; Human cancer; Oncoprotein; Tumor suppressor; Ubiquitin