title: Elevated circulating level of a cytokine, pancreatic-derived factor, is associated with metabolic syndrome components in a Chinese population.
abstract: OBJECTIVE
  Pancreatic-derived factor (PANDER) is an important factor involved in obesity, glucose intolerance and abnormal lipid metabolism in animals. Nevertheless, the relationship between PANDER and metabolic syndrome (MetS) in humans has not yet been reported.
  
  
  METHODS
  To determinate the relationship between PANDER and MetS components, 212 individuals aged between 40 and 65 years were recruited. Fasting plasma PANDER and other variables were measured. Correlations of plasma PANDER and other variables were carried out. Plasma PANDER level was compared in participants with no metabolic components and those with any metabolic components, as well as in normal glucose tolerance, impaired glucose tolerance and diabetes mellitus participants.
  
  
  RESULTS
  In all the participants, there were 65 participants in the no metabolic components group and 147 participants in the any metabolic components group. Plasma PANDER level was increased with the number of MetS components (P < 0.05) and correlated with metabolic score (r = 0. 529, P < 0.001). In addition, plasma PANDER significantly correlated with fasting plasma glucose (r = 0.187, P = 0.046), 2-h plasma glucose (r = 0.195, P = 0.035), homeostasis model assessment of β-cell function (r = -0.191, P = 0.039), triglyceride (r = 0.305, P = 0.001) and high-density lipoprotein cholesterol (r = -0.333, P < 0.001). Using multivariable logistic regression analysis, circulating PANDER was associated with an increased risk ratio of impaired glucose tolerance or diabetes mellitus (odds ratio 2.22, 95% confidence interval 1.15-4.42, P = 0.018) after adjustment of the other possible confounders.
  
  
  CONCLUSIONS
  Circulating level of PANDER in relation to the accumulation in MetS suggested that persons with elevated levels of PANDER were associated with an increased risk of metabolic syndrome.
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Xiaopei
authors.initials: X
authors.lastname: Cao
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Chijiao
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Fenghua
authors.initials: F
authors.lastname: Lai
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Hong
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Huimei
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Yanbing
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D002681:China / Q000453:epidemiology; D016207:Cytokines / Q000097:blood*; D048909:Diabetes Complications / Q000097:blood / Q000453:epidemiology; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications / Q000453:epidemiology; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*
chemical_list: D016207:Cytokines; C577825:FAM3B protein, human; D009363:Neoplasm Proteins
keywords: Impaired glucose tolerance; Metabolic syndrome; Pancreatic-derived factor