title: Xeroderma pigmentosum with bilateral ocular surface squamous neoplasia and review of the literature.
abstract: Xeroderma pigmentosum is a rare genetic disorder associated with various ocular malignancies. Here we report a single paediatric case of xeroderma pigmentosum with bilateral ocular surface squamous neoplasia (OSSN) presenting with diffuse lesion in one eye and a large mass in the other eye. Diffuse OSSN in one eye was treated with topical chemotherapy using mitomycin-C (0.04%) and the large OSSN in the other eye was treated with a combination of surgery and topical chemotherapy. Long-term follow-up and a multimodality treatment approach are necessary to identify and manage recurrences of OSSN in XP.
authors.affiliation: Department of Ophthalmology, Shri Ganesh Vinayak Eye Hospital, Raipur, Chhattisgarh, India.
authors.forename: Charudutt
authors.initials: C
authors.lastname: Kalamkar
authors.affiliation: Shri Ganesh Vinayak Eye Hospital, Raipur, Chhattisgarh, India.
authors.forename: Nishant
authors.initials: N
authors.lastname: Radke
authors.affiliation: Shri Ganesh Vinayak Eye Hospital, Raipur, Chhattisgarh, India.
authors.forename: Amrita
authors.initials: A
authors.lastname: Mukherjee
authors.affiliation: Shri Ganesh Vinayak Eye Hospital, Raipur, Chhattisgarh, India.
authors.forename: Snehal
authors.initials: S
authors.lastname: Radke
mesh_terms: D000287:Administration, Topical; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D002648:Child; D065426:Cytoreduction Surgical Procedures / Q000379:methods; D005134:Eye Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome; D014983:Xeroderma Pigmentosum / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*
chemical_list: D016685:Mitomycin