title: Chronic interstitial pneumonia in young patients undergoing lung transplantation or autopsy: clinico-radiologic-pathologic observations from a single institution.
abstract: OBJECTIVE
  To retrospectively evaluate high-resolution computed tomography (HRCT) findings and clinical diagnoses of chronic interstitial pneumonia (IP) with a poor prognosis in young patients (≤50 years).
  
  
  METHODS
  HRCT images of 8 men and 7 women (mean age 34.8 years) obtained before lung transplantation or autopsy were reviewed. After reviewing whole lung specimens and pathologic diagnoses, all patients were clinically diagnosed according to the 2010 idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP) consensus statement.
  
  
  RESULTS
  HRCT images revealed intralobular reticular opacity, air cysts, ground glass opacity, traction bronchiectasis, and interlobular septal thickening. Intralobular reticular opacity was the most extensive finding. Abnormal findings existed predominantly in both the peripheral and lower lung zones in only 1 patient. Classifications of HRCT patterns were "UIP" (n = 2), "inconsistent with UIP" (n = 11), and "indeterminate UIP" (n = 2). Multidisciplinary diagnoses were "IPF/UIP" (n = 1), "possible IPF/UIP" (n = 1), "IP with connective tissue disease" (n = 7), "fibrotic nonspecific IP" (n = 1), and "unclassified IP" (n = 5).
  
  
  CONCLUSIONS
  The most extensive HRCT finding was intralobular reticular opacity. Most HRCT images differed from typical IPF/UIP, and IPF/UIP was uncommon in young patients with chronic IP with a poor prognosis.
authors.affiliation: Department of Radiology, Okayama University Medical School, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
authors.forename: Mayu
authors.initials: M
authors.lastname: Uka
authors.affiliation: Department of Radiology, Okayama University Medical School, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan. iguchi@ba2.so-net.ne.jp.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Iguchi
authors.affiliation: Department of Diagnostic Radiology 2, Kawasaki Hospital, Kawasaki Medical School, Okayama, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Kato
authors.affiliation: Department of Radiology, Okayama Red Cross Hospital, Okayama, Japan.
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Hayashi
authors.affiliation: Department of Pathology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yamadori
authors.affiliation: Center for Innovative Clinical Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Mitsuhashi
authors.affiliation: General Thoracic Surgery and Center for Innovative Clinical Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Oto
authors.affiliation: Department of Radiology, Okayama University Medical School, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Sato
authors.affiliation: Department of Radiology, Okayama University Medical School, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Kanazawa
mesh_terms: D000293:Adolescent; D000328:Adult; D001344:Autopsy; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000000981:diagnostic imaging* / Q000473:pathology*; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: Chronic interstitial pneumonia; High-resolution computed tomography; Young