title: A model of space-fractional-order diffusion in the glial scar.
abstract: Implantation of neuroprosthetic electrodes induces a stereotypical state of neuroinflammation, which is thought to be detrimental for the neurons surrounding the electrode. Mechanisms of this type of neuroinflammation are still poorly understood. Recent experimental and theoretical results point to a possible role of the diffusing species in this process. The paper considers a model of anomalous diffusion occurring in the glial scar around a chronic implant in two simple geometries - a separable rectilinear electrode and a cylindrical electrode, which are solvable exactly. We describe a hypothetical extended source of diffusing species and study its concentration profile in steady-state conditions. Diffusion transport is assumed to obey a fractional-order Fick law, derivable from physically realistic assumptions using a fractional calculus approach. Presented fractional-order distribution morphs into integer-order diffusion in the case of integral fractional exponents. The model demonstrates that accumulation of diffusing species can occur and the scar properties (i.e. tortuosity, fractional order, scar thickness) and boundary conditions can influence such accumulation. The observed shape of the concentration profile corresponds qualitatively with GFAP profiles reported in the literature. The main difference with respect to the previous studies is the explicit incorporation of the apparatus of fractional calculus without assumption of an ad hoc tortuosity parameter. The approach can be adapted to other studies of diffusion in biological tissues, for example of biomolecules or small drug molecules.
authors.affiliation: Environment, Health and Safety, Neuroscience Research Flanders, IMEC, Kapeldreef 75, 3001 Leuven, Belgium. Electronic address: Dimiter.Prodanov@imec.be.
authors.forename: Dimiter
authors.initials: D
authors.lastname: Prodanov
authors.affiliation: LCEN3, Department of Neurology, Institute of Neuroscience, Ghent University, Ghent, Belgium. Electronic address: jdelbeke@gmail.com.
authors.forename: Jean
authors.initials: J
authors.lastname: Delbeke
mesh_terms: D002921:Cicatrix / Q000473:pathology*; D004058:Diffusion; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D008954:Models, Biological; D009457:Neuroglia / Q000473:pathology*; D009716:Numerical Analysis, Computer-Assisted; D019736:Prostheses and Implants
chemical_list: D005904:Glial Fibrillary Acidic Protein
keywords: Diffusion; Fractional calculus; Neuroinflammation; Partial differential equation; Transport equation