title: Results of a round-robin exercise on read-across.
abstract: A round-robin exercise was conducted within the CALEIDOS LIFE project. The participants were invited to assess the hazard posed by a substance, applying in silico methods and read-across approaches. The exercise was based on three endpoints: mutagenicity, bioconcentration factor and fish acute toxicity. Nine chemicals were assigned for each endpoint and the participants were invited to complete a specific questionnaire communicating their conclusions. The interesting aspect of this exercise is the justification behind the answers more than the final prediction in itself. Which tools were used? How did the approach selected affect the final answer?
authors.affiliation: a IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Milano , Italy.
authors.forename: E
authors.initials: E
authors.lastname: Benfenati
authors.affiliation: a IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Milano , Italy.
authors.forename: M
authors.initials: M
authors.lastname: Belli
authors.affiliation: b Direcção-Geral da Saúde , Lisboa , Portugal.
authors.forename: T
authors.initials: T
authors.lastname: Borges
authors.affiliation: c INFOTOX, Consultores de Riscos Ambientais e Tecnológicos, Lda , Lisboa , Portugal.
authors.forename: E
authors.initials: E
authors.lastname: Casimiro
authors.affiliation: d Universitat Rovira i Virgili , Tarragona , Spain.
authors.forename: J
authors.initials: J
authors.lastname: Cester
authors.affiliation: d Universitat Rovira i Virgili , Tarragona , Spain.
authors.forename: A
authors.initials: A
authors.lastname: Fernandez
authors.affiliation: e Politecnico di Milano, Dipartimento di Elettronica e Informazione , Milan , Italy.
authors.forename: G
authors.initials: G
authors.lastname: Gini
authors.affiliation: f Division of Genetics and Mutagenesis , National Institute of Health Sciences , Tokyo , Japan.
authors.forename: M
authors.initials: M
authors.lastname: Honma
authors.affiliation: g Umweltbundesamt GmbH , Vienna , Austria.
authors.forename: M
authors.initials: M
authors.lastname: Kinzl
authors.affiliation: h Centro REACH S.r.l. , Milan , Italy.
authors.forename: R
authors.initials: R
authors.lastname: Knauf
authors.affiliation: i Kode S.r.l . Pisa , Italy.
authors.forename: A
authors.initials: A
authors.lastname: Manganaro
authors.affiliation: j Institut National de l'Environnement Industriel et des Risques , Verneuil-en-Halatte , France.
authors.forename: E
authors.initials: E
authors.lastname: Mombelli
authors.affiliation: a IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Milano , Italy.
authors.forename: M I
authors.initials: MI
authors.lastname: Petoumenou
authors.affiliation: g Umweltbundesamt GmbH , Vienna , Austria.
authors.forename: M
authors.initials: M
authors.lastname: Paparella
authors.affiliation: k Istituto Superiore per la Protezione e la Ricerca Ambientale , Rome , Italy.
authors.forename: P
authors.initials: P
authors.lastname: Paris
authors.affiliation: a IRCCS - Istituto di Ricerche Farmacologiche Mario Negri , Milano , Italy.
authors.forename: G
authors.initials: G
authors.lastname: Raitano
mesh_terms: D000818:Animals; D003198:Computer Simulation; D005399:Fishes; D015386:Hazardous Substances / Q000633:toxicity*; D006801:Humans; D009152:Mutagenicity Tests; D021281:Quantitative Structure-Activity Relationship; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012984:Software; D011795:Surveys and Questionnaires; D023382:Toxicity Tests, Acute; D035501:Uncertainty
chemical_list: D015386:Hazardous Substances
keywords: Read-across; bioconcentration factor; mutagenicity