title: Intravenous lacosamide in clinical practice-Results from an independent registry.
abstract: OBJECTIVE
  This non-interventional study was conducted to evaluate the efficacy and tolerability of intravenous lacosamide (LCM-iv) under routine conditions in daily clinical practice as a prospective registry.
  
  
  METHODS
  Patients with any type of seizure or epilepsy syndrome were recruited in 16 neurological and neuropediatric centers in Germany if the treating physician decided to administer LCM-iv for any reason. Observation time per patient was 10 days with daily documentation of LCM-iv administration, type and frequency of seizures, currently used drugs and doses, and adverse events. Treatment efficacy, tolerability, and handling of LCM-iv were assessed using a five-step scale.
  
  
  RESULTS
  In 119 patients treating physicians classified epilepsies as focal in 66.1% and generalized in 17.4% (16.5% unclassifiable). Most common etiologies of seizures were tumors (36.1%) and cerebrovascular diseases (21.8%). Reasons for LCM-iv treatment included preparation for surgery (25.2%), convulsive (24.4%) and non-convulsive (18.5%) status epilepticus (SE), series of seizures (16.0%), gastrointestinal causes (5.9%), and acute seizures (4.2%). The median dose of LCM-iv was 300mg per day. In 45 of 64 patients (70.3%) with SE or series of seizures, epileptic activity ceased during observation time. Five patients showed abnormalities in ECG prior to the infusion and one patient afterwards, but during infusion no abnormalities were reported. Treating physicians rated efficacy and tolerability as very good or good in 77.6% and 93.1% of patients, respectively.
  
  
  CONCLUSIONS
  This large and independent multicenter registry on the use of LCM-iv in clinical practice demonstrates that LCM-iv is well-tolerated and highly efficacious when given in emergency situations, including patients experiencing SE. It is advisable to perform an electrocardiogram prior to LCM-iv administration.
authors.affiliation: Department of Neurology, University Hospital Schleswig-Holstein, Kiel, Germany. Electronic address: n.lang@neurologie.uni-kiel.de.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lang
authors.affiliation: Department of Neurosurgery, University Hospital Regensburg, Germany.
authors.forename: Max
authors.initials: M
authors.lastname: Lange
authors.affiliation: Department of Neurology, University Hospital Magdeburg, Germany.
authors.forename: Friedhelm C
authors.initials: FC
authors.lastname: Schmitt
authors.affiliation: Department of Neurology, St. Johannes Hospital, Troisdorf, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Bös
authors.affiliation: Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Germany.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Weber
authors.affiliation: Department of Neurology, Lindenbrunn Hospital, Coppenbrügge, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Evers
authors.affiliation: Department of Neurology, University Hospital Cologne, Germany.
authors.forename: Lothar
authors.initials: L
authors.lastname: Burghaus
authors.affiliation: Department of Neurology, Klinikum Osnabrück, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Kellinghaus
authors.affiliation: Neuropediatric Department, University Hospital Heidelberg, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Schubert-Bast
authors.affiliation: Department of Neurology, University Hospital Heidelberg, Germany.
authors.forename: Julian
authors.initials: J
authors.lastname: Bösel
authors.affiliation: Department of Neurology, Johanna-Etienne-Hospital, Neuss, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Lammers
authors.affiliation: Neurology Specialist Hospital Dietenbronn, Schwendi, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Sabolek
authors.affiliation: Department of Neuropediatrics, University Hospital Schleswig-Holstein, Kiel, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: van Baalen
authors.affiliation: Department of Neurology, University Hospital Münster, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Dziewas
authors.affiliation: Department of Neurology, Martha-Maria Hospital, Halle (Saale), Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Kraft
authors.affiliation: Department of Neuropediatrics, University Hospital Tübingen, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Ruf
authors.affiliation: Department of Neuropediatrics, University Hospital Schleswig-Holstein, Kiel, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Stephani
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D061605:Administration, Intravenous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D005858:Germany; D006801:Humans; D007223:Infant; D000078334:Lacosamide; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D012042:Registries; D012640:Seizures / Q000188:drug therapy; D013226:Status Epilepticus / Q000188:drug therapy; D055815:Young Adult
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide
keywords: Efficacy; Epilepsy; Lacosamide iv; Seizure; Status epilepticus; Tolerability