title: Endothelial Glycocalyx: Shedding Light on Malaria Pathogenesis.
abstract: Malaria is estimated to kill 438 000 people annually, mostly due to severe malaria, which is closely associated with microcirculatory vasculopathy, although its pathogenesis remains incompletely understood. Here, we propose that the largely ignored glycocalyx of the vascular endothelium plays an important role in facilitating the pathogenesis of severe malaria.
authors.affiliation: Centre of Medical Parasitology, Department of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark. Electronic address: casperhempel@gmail.com.
authors.forename: Casper
authors.initials: C
authors.lastname: Hempel
authors.affiliation: Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
authors.forename: Erica M
authors.initials: EM
authors.lastname: Pasini
authors.affiliation: Centre of Medical Parasitology, Department of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Jørgen A L
authors.initials: JAL
authors.lastname: Kurtzhals
mesh_terms: D000818:Animals; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology*; D004912:Erythrocytes / Q000469:parasitology; D019276:Glycocalyx / Q000378:metabolism* / Q000473:pathology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000378:metabolism / Q000469:parasitology* / Q000473:pathology*; D051379:Mice; D008808:Mice, Inbred CBA; D010961:Plasmodium / Q000472:pathogenicity*
keywords: endothelial glycocalyx; malaria; pathogenesis