title: [Efficacy of levocarnitine for tyrosine kinase inhibitor-induced painful muscle cramps in patients with chronic myelogenous leukemia].
abstract: Muscle cramps are side effects commonly associated with tyrosine kinase inhibitor (TKI) treatment. Patients suffering from muscle cramps are treated with various medications such as calcium, magnesium and vitamin supplements, but these therapies are often ineffective. We report two patients with chronic myelogenous leukemia who developed muscle cramps caused by TKI. These patients were treated successfully with levocarnitine. Both of our cases revealed the beneficial effects of levocarnitine treatment on TKI-induced muscle cramps.
authors.affiliation: Dept. of Gastroenterology and Hematology/Clinical Oncology, Internal Medicine, Steel Memorial Muroran Hospital.
authors.forename: Michiko
authors.initials: M
authors.lastname: Yamada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuroda
authors.forename: Saori
authors.initials: S
authors.lastname: Shimoyama
authors.forename: Ryo
authors.initials: R
authors.lastname: Ito
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sugama
authors.forename: Ken
authors.initials: K
authors.lastname: Sato
authors.forename: Natsumi
authors.initials: N
authors.lastname: Yamauchi
authors.forename: Hiroto
authors.initials: H
authors.lastname: Horiguchi
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakamura
authors.forename: Kota
authors.initials: K
authors.lastname: Hamaguchi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Abe
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Fujii
authors.forename: Masahiro
authors.initials: M
authors.lastname: Maeda
authors.forename: Junji
authors.initials: J
authors.lastname: Kato
mesh_terms: D000328:Adult; D002331:Carnitine / Q000627:therapeutic use*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009120:Muscle Cramp / Q000139:chemically induced / Q000188:drug therapy*; D010146:Pain / Q000209:etiology; D047428:Protein Kinase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*
chemical_list: D047428:Protein Kinase Inhibitors; D011505:Protein-Tyrosine Kinases; D002331:Carnitine