title: Identification and characterization of avian hepatitis E virus genotype 2 from chickens with hepatitis-splenomegaly syndrome in Korea.
abstract: A new avian hepatitis E virus (HEV) GI-B was identified in broiler breeders with hematomas, liver rupture, and splenomegaly, along with excessive abdominal fat, in Korea. Previously, genotype 1 had been identified in avian HEV strains in Korea. Complete sequence analyses revealed that the new avian HEV clustered in genotype 2, which has been identified in the USA and Spain; the GI-B isolate was closely related to the USA prototype avian HEV isolated from a chicken with hepatitis-splenomegaly syndrome. Although some HEV genotypes show a geographical distribution pattern, the discovery of genotype 2 in addition to genotype 1 in Korea suggests that the geographical grouping might be reconsidered. These findings have important implications for understanding the global epidemiology and spread of avian HEV.
authors.affiliation: College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon, 200-701, Republic of Korea.
authors.forename: Hyun-Woo
authors.initials: HW
authors.lastname: Moon
authors.affiliation: College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon, 200-701, Republic of Korea.
authors.forename: Byung-Woo
authors.initials: BW
authors.lastname: Lee
authors.affiliation: College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon, 200-701, Republic of Korea.
authors.forename: Haan Woo
authors.initials: HW
authors.lastname: Sung
authors.affiliation: College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon, 200-701, Republic of Korea.
authors.forename: Byung-Il
authors.initials: BI
authors.lastname: Yoon
authors.affiliation: College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon, 200-701, Republic of Korea. kwonhm@kangwon.ac.kr.
authors.forename: Hyuk Moo
authors.initials: HM
authors.lastname: Kwon
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens / Q000821:virology*; D005838:Genotype; D016751:Hepatitis E / Q000821:virology*; D006524:Hepatitis, Viral, Animal / Q000821:virology*; D052678:Hepevirus / Q000235:genetics*; D010802:Phylogeny; D011201:Poultry Diseases / Q000821:virology*; D056910:Republic of Korea; D013030:Spain; D013163:Splenomegaly / Q000821:virology*
keywords: Avian hepatitis E virus (HEV); Chickens; Complete genome sequence; Genotypes; Hypervariable region