title: Structural and Functional Magnetic Resonance Imaging: Mild Cognitive Impairment and Alzheimer Disease.
abstract: Magnetic resonance (MR) imaging is playing an increasingly pivotal role in the clinical management of dementia, including Alzheimer disease (AD). In addition to established MR imaging procedures, the introduction of advanced instrumentation such as 7-T MR imaging, as well as novel MR imaging sequences such as arterial spin labeling, MR spectroscopy, diffusion tensor imaging, and resting-state functional MR imaging, may open new pathways toward improved diagnosis of AD even in early stages of disease such as mild cognitive impairment (MCI). This article describes the typical findings of established and new MR imaging procedures in healthy aging, MCI, and AD.
authors.affiliation: Department of Radiology, University Hospital Cologne, Kerpener Street 62, Cologne 50937, Germany.
authors.forename: Hannah
authors.initials: H
authors.lastname: Lockau
authors.affiliation: Department of Psychiatry, German Center for Neurodegenerative Diseases (DZNE), University of Bonn, Sigmund-Freud-Straße 25, Bonn 53105, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Jessen
authors.affiliation: Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Street 8, Mainz 55131, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Fellgiebel
authors.affiliation: Department of Nuclear Medicine, University Hospital Cologne, Kerpener Street 62, Cologne 50937, Germany. Electronic address: alexander.drzezga@uk-koeln.de.
authors.forename: Alexander
authors.initials: A
authors.lastname: Drzezga
keywords: Alzheimer disease; Arterial spin labeling; Dementia; Diffusion tensor imaging; Magnetic resonance imaging; Magnetic resonance spectroscopy; Mild cognitive impairment