title: Peculiarities of the Inflammatory Process in the Reproductive Organs of C57Bl/6 Female Mice with Experimental Tuberculosis.
abstract: Intravenous infection of C57Bl/6 female mice with M. tuberculosis H37Rv led to involvement of the lungs and dissemination of the tuberculous infection to the abdominal and pelvic organs. M. tuberculosis were detected in the lungs and spleen in 14, 35, and 90 days and in the uterine horns in 90 days after infection. Morphological analysis of organs showed successive development of exudative necrotic tuberculosis of the lungs, acute and chronic nonspecific inflammation in the reproductive organs (vagina, uterus, and uterine horns). The inflammatory process in the reproductive organs was associated with the development of anaerobic dysbiosis, that was most pronounced in 35 days after infection. Antituberculous therapy was followed by reduction of M. tuberculosis count in the lungs and spleen in 60 and 90 days after infection, eliminatation of M. tuberculosis in the uterine horns, arrest of nonspecific inflammation in female reproductive organs, recovery of the balance between aerobic and anaerobic microflora, and development of candidiasis of the urogenital mucosa.
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
authors.affiliation: Research Central Institute of Tuberculosis, Moscow, Russia. kajukovalnp@gmail.com.
authors.forename: S I
authors.initials: SI
authors.lastname: Kayukova
authors.affiliation: Research Central Institute of Tuberculosis, Moscow, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Bocharova
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Donnikov
authors.affiliation: Research Central Institute of Tuberculosis, Moscow, Russia.
authors.forename: L N
authors.initials: LN
authors.lastname: Lepekha
authors.affiliation: Research Central Institute of Tuberculosis, Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Demikhova
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Uvarova
authors.affiliation: Research Central Institute of Tuberculosis, Moscow, Russia.
authors.forename: Yu S
authors.initials: YS
authors.lastname: Berezovskii
authors.affiliation: Research Central Institute of Tuberculosis, Moscow, Russia.
authors.forename: T G
authors.initials: TG
authors.lastname: Smirnova
mesh_terms: D000818:Animals; D004269:DNA, Bacterial / Q000235:genetics; D004195:Disease Models, Animal; D005260:Female; D008168:Lung / Q000276:immunology / Q000473:pathology; D008810:Mice, Inbred C57BL; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology; D014621:Vagina / Q000276:immunology / Q000382:microbiology*; D014627:Vaginitis / Q000276:immunology / Q000382:microbiology*; D014657:Vasculitis / Q000276:immunology / Q000382:microbiology
chemical_list: D004269:DNA, Bacterial
keywords: experimental tuberculosis; inbred mice; inflammation; reproductive organs