title: Magnetic Particle Imaging: A Resovist Based Marking Technology for Guide Wires and Catheters for Vascular Interventions.
abstract: Magnetic particle imaging (MPI) is able to provide high temporal and good spatial resolution, high signal to noise ratio and sensitivity. Furthermore, it is a truly quantitative method as its signal strength is proportional to the concentration of its tracer, superparamagnetic iron oxide nanoparticles (SPIOs), over a wide range practically relevant concentrations. Thus, MPI is proposed as a promising future method for guidance of vascular interventions. To implement this, devices such as guide wires and catheters have to be discernible in MPI, which can be achieved by coating already commercially available devices with SPIOs. In this proof of principle study the feasibility of that approach is demonstrated. First, a Ferucarbotran-based SPIO-varnish was developed by embedding Ferucarbotran into an organic based solvent. Subsequently, the biocompatible varnish was applied to a commercially available guidewire and diagnostic catheter for vascular interventional purposes. In an interventional setting using a vessel phantom, the coating proved to be mechanically and chemically stable and thin enough to ensure normal handling as with uncoated devices. The devices were visualized in 3D on a preclinical MPI demonstrator using a system function based image reconstruction process. The system function was acquired with a probe of the dried varnish prior to the measurements. The devices were visualized with a very high temporal resolution and a simple catheter/guide wire maneuver was demonstrated.
authors.forename: Julian
authors.initials: J
authors.lastname: Haegele
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Panagiotopoulos
authors.forename: Sjef
authors.initials: S
authors.lastname: Cremers
authors.forename: Jurgen
authors.initials: J
authors.lastname: Rahmer
authors.forename: Jochen
authors.initials: J
authors.lastname: Franke
authors.forename: Robert L
authors.initials: RL
authors.lastname: Duschka
authors.forename: Sarah
authors.initials: S
authors.lastname: Vaalma
authors.forename: Michael
authors.initials: M
authors.lastname: Heidenreich
authors.forename: Jorn
authors.initials: J
authors.lastname: Borgert
authors.forename: Paul
authors.initials: P
authors.lastname: Borm
authors.forename: Jorg
authors.initials: J
authors.lastname: Barkhausen
authors.forename: Florian M
authors.initials: FM
authors.lastname: Vogt
mesh_terms: D057785:Catheters; D003952:Diagnostic Imaging / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D058185:Magnetite Nanoparticles; D019047:Phantoms, Imaging
chemical_list: D058185:Magnetite Nanoparticles