title: Metabolic Actions of the Type 1 Cholecystokinin Receptor: Its Potential as a Therapeutic Target.
abstract: Cholecystokinin (CCK) regulates appetite and reduces food intake by activating the type 1 CCK receptor (CCK1R). Attempts to develop CCK1R agonists for obesity have yielded active agents that have not reached clinical practice. Here we discuss why, along with new strategies to target CCK1R more effectively. We examine signaling events and the possibility of developing agents that exhibit ligand-directed bias, to dissociate satiety activity from undesirable side effects. Potential allosteric sites of modulation are also discussed, along with desired properties of a positive allosteric modulator (PAM) without intrinsic agonist action as another strategy to treat obesity. These new types of CCK1R-active drugs could be useful as standalone agents or as part of a rational drug combination for management of obesity.
authors.affiliation: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, 85259, USA. Electronic address: miller@mayo.edu.
authors.forename: Laurence J
authors.initials: LJ
authors.lastname: Miller
authors.affiliation: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, 85259, USA.
authors.forename: Aditya J
authors.initials: AJ
authors.lastname: Desai
mesh_terms: D000494:Allosteric Regulation / Q000235:genetics / Q000502:physiology; D000818:Animals; D002766:Cholecystokinin / Q000378:metabolism; D006801:Humans; D009765:Obesity / Q000235:genetics / Q000378:metabolism; D043886:Receptor, Cholecystokinin A / Q000819:agonists / Q000378:metabolism; D011949:Receptors, Cholecystokinin / Q000819:agonists / Q000235:genetics / Q000378:metabolism*
chemical_list: D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin; D002766:Cholecystokinin
keywords: biased agonists; cholecystokinin; positive allosteric modulators; satiety; type 1 cholecystokinin receptor