title: Delphinidin prevents disuse muscle atrophy and reduces stress-related gene expression.
abstract: Delphinidin is a member of the anthocyanidin class of plant pigments. We examined the effects of delphinidin on muscle atrophy. Oral administration of delphinidin suppressed the muscle weight loss induced by mechanical unloading. Microarray analysis showed that delphinidin suppresses the upregulation of oxidative stress-related gene expression, including the expression of Cbl-b. Thus, delphinidin may prevent unloading-mediated muscle atrophy.
authors.affiliation: a Division of Applied Biological Chemistry, Faculty of Agriculture, Department of Bioscience and Biotechnology , Kyushu University , Fukuoka-shi , Japan.
authors.forename: Motoki
authors.initials: M
authors.lastname: Murata
authors.affiliation: a Division of Applied Biological Chemistry, Faculty of Agriculture, Department of Bioscience and Biotechnology , Kyushu University , Fukuoka-shi , Japan.
authors.forename: Reia
authors.initials: R
authors.lastname: Kosaka
authors.affiliation: a Division of Applied Biological Chemistry, Faculty of Agriculture, Department of Bioscience and Biotechnology , Kyushu University , Fukuoka-shi , Japan.
authors.forename: Kana
authors.initials: K
authors.lastname: Kurihara
authors.affiliation: a Division of Applied Biological Chemistry, Faculty of Agriculture, Department of Bioscience and Biotechnology , Kyushu University , Fukuoka-shi , Japan.
authors.forename: Shuya
authors.initials: S
authors.lastname: Yamashita
authors.affiliation: a Division of Applied Biological Chemistry, Faculty of Agriculture, Department of Bioscience and Biotechnology , Kyushu University , Fukuoka-shi , Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tachibana
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000235:genetics / Q000378:metabolism; D002460:Cell Line; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D019417:Hindlimb Suspension; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D009133:Muscular Atrophy / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D032446:Myoblasts / Q000187:drug effects / Q000378:metabolism; D000074663:NADPH Oxidase 4; D019255:NADPH Oxidases / Q000235:genetics / Q000378:metabolism; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D050721:Proto-Oncogene Proteins c-cbl / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D000072105:Superoxide Dismutase-1 / Q000235:genetics / Q000378:metabolism; D020830:rac1 GTP-Binding Protein / Q000235:genetics / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000872:Anthocyanins; C118387:Cblb protein, mouse; D009479:Neuropeptides; C484602:Rac1 protein, mouse; D002374:Catalase; C000606291:Sod1 protein, mouse; D000072105:Superoxide Dismutase-1; D000074663:NADPH Oxidase 4; D019255:NADPH Oxidases; C422943:Nox4 protein, mouse; D050721:Proto-Oncogene Proteins c-cbl; D020830:rac1 GTP-Binding Protein; C017185:delphinidin
keywords: Cbl-b; Delphinidin; muscle atrophy