title: Dose Dependence of the Anticoagulant Effect of Intravenously Administered Cellulose Sulfate.
abstract: Experiments on rabbits showed that increasing the dose of intravenously administered cellulose sulfate from wheat straw (dynamic viscosity 3.4 cP, sulfur content 14.1%) increased plasma clotting time in some coagulation tests and plasma anticoagulant activity. When cellulose sulfate was administered in the dose of 1 mg/kg, plasma clotting time in the presence of the anticoagulant (5 min after administration) was ~3-fold higher than after saline administration.
authors.affiliation: Hematological Research Center, Ministry of Health of the Russian Federation, Moscow, Russia. nndrozd@mail.ru.
authors.forename: N N
authors.initials: NN
authors.lastname: Drozd
authors.affiliation: Institute of Chemistry and Chemical Technology, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Kuznetsova
authors.affiliation: Hematological Research Center, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: T B
authors.initials: TB
authors.lastname: Kalinina
authors.affiliation: Institute of Chemistry and Chemical Technology, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia.
authors.forename: N Yu
authors.initials: NY
authors.lastname: Vasilieva
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage*; D001777:Blood Coagulation / Q000187:drug effects; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D015951:Factor Xa / Q000378:metabolism; D006493:Heparin / Q000494:pharmacology; D011817:Rabbits
chemical_list: D000925:Anticoagulants; D002482:Cellulose; D006493:Heparin; C020254:cellulose sulfate; D015951:Factor Xa
keywords: aIIa activity; aXa activity; anticoagulant; cellulose sulfate