title: H-Type Hypertension and C Reactive Protein in Recurrence of Ischemic Stroke.
abstract: Hypertension with high homocysteine (HHcy) (H-type hypertension) and C reactive protein (CRP) can increase the incidence of ischemic stroke. However, it is not clear whether recurrent ischemic stroke (RIS) is related to H-type hypertension and CRP. The present study investigated the correlation of H-type hypertension and CRP level with RIS. Totally, 987 consecutive patients with acute ischemic stroke were recruited in a teaching hospital in Henan province, China during March 2014 to March 2015. The demographic and clinical characteristics and blood biochemical parameters of patients were analyzed. Elevated levels of CRP and homocysteine (Hcy) were defined as >8.2 mg/L and 10 μmol/L, respectively. Among the 987 patients, 234 were RIS. Thirty-eight percent of RIS patients had elevated CRP level and 91.5% of RIS patients had HHcy. In multivariate analysis, adjusted odds ratio (OR) of RIS in patients aged ≥60 years was 1.576 (95% CI: 1.125-2.207), in male patients 1.935 (95% CI: 1.385-2.704), in patients with diabetes 1.463 (95% CI: 1.037-2.064), CRP levels 1.013 (95% CI: 1.006-1.019), simple hypertension 3.370 (95% CI: 1.15-10.183), and H-type hypertension 2.990 (95% CI: 1.176-7.600). RIS was associated with older age, male, diabetes, H-type hypertension and CRP. Controlling H-type hypertension and CRP level may reduce the risk of RIS.
authors.affiliation: Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, China. zq71200@163.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Guangming New District People's Hospital &amp; Community Health Service Management Center of Guangming Area, Shenzhen 518000, China. qiudexing66@139.com.
authors.forename: De-Xing
authors.initials: DX
authors.lastname: Qiu
authors.affiliation: Internal Medicine-Neurology, Huaihe Hospital, Henan University, Kaifeng 475000, China. 15225475536@163.com.
authors.forename: Rong-Li
authors.initials: RL
authors.lastname: Fu
authors.affiliation: Basical School, Guangzhou Medical University, Guangzhou 510180, China. xutianfen01@sina.com.
authors.forename: Tian-Fen
authors.initials: TF
authors.lastname: Xu
authors.affiliation: Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, China. jing53905@163.com.
authors.forename: Meng-Juan
authors.initials: MJ
authors.lastname: Jing
authors.affiliation: Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Guangzhou 510180, China. zhanghuishan25@163.com.
authors.forename: Hui-Shan
authors.initials: HS
authors.lastname: Zhang
authors.affiliation: Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, China. 15226003150@163.com.
authors.forename: He-Hong
authors.initials: HH
authors.lastname: Geng
authors.affiliation: Department of Public Health, School of Public Health, Graduate School of Guizhou Medical University, Guiyang 550025, China. zlc3050@163.com.
authors.forename: Long-Chao
authors.initials: LC
authors.lastname: Zheng
authors.affiliation: Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, China. peixi001@163.com.|Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Guangzhou 510180, China. peixi001@163.com.
authors.forename: Pei-Xi
authors.initials: PX
authors.lastname: Wang
mesh_terms: D002545:Brain Ischemia / Q000097:blood* / Q000453:epidemiology; D002097:C-Reactive Protein / Q000032:analysis*; D002681:China / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012008:Recurrence; D020521:Stroke / Q000097:blood* / Q000453:epidemiology
chemical_list: D006710:Homocysteine; D002097:C-Reactive Protein
keywords: C reactive protein; H-type hypertension; recurrence ischemic stroke