title: Serum levels of C1q/TNF-related protein-1 (CTRP-1) are closely associated with coronary artery disease.
abstract: BACKGROUND
  Complement C1q tumor necrosis factor related proteins (CTRPs) have been proved to have diverse biological influences on cardiovascular system. CTRP 1 is a member of the CTRP superfamily, however, the relevance with coronary artery disease (CAD) are seldom explored. This study was designed to investigate the correlation between serum levels of CTRP 1 and CAD.
  
  
  METHODS
  CTRP 1 levels of 150 CAD patients and 50 non-CAD subjects were determined by enzymelinked immunosorbent assay. Further analysis of CTRP 1 levels in different stages and lesion vessels of CAD were conducted.
  
  
  RESULTS
  Serum levels of CTRP 1 in CAD patients were significantly elevated, and it was increased with the severity of CAD. CTRP 1 level in acute myocardial infarction group was much higher than that in stable/unstable angina and non-CAD groups. And significant differences of CTRP 1 were also found between single-vessel disease and triple-vessel disease. Multiple logistic regression analysis showed that CTRP 1 was an independent risk factor of the occurrence of myocardial infarction.
  
  
  CONCLUSIONS
  Increased serum CTRP 1 levels were closely associated with the prevalence and severity of CAD, it might be regarded as a marker for myocardial infarction.
authors.affiliation: Clinical Laboratory, The 305 Hospital of the People's Liberation Army, Beijing, 100017, China. huizhongwang86@126.com.
authors.forename: Huizhong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Clinical Laboratory, The 305 Hospital of the People's Liberation Army, Beijing, 100017, China.
authors.forename: Ru
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Cardiology, The 305 Hospital of the People's Liberation Army, Beijing, 100017, China.
authors.forename: Dayong
authors.initials: D
authors.lastname: Du
authors.affiliation: Clinical Laboratory, The 305 Hospital of the People's Liberation Army, Beijing, 100017, China.
authors.forename: Fangliang
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Cardiology, The 305 Hospital of the People's Liberation Army, Beijing, 100017, China.
authors.forename: Yuntian
authors.initials: Y
authors.lastname: Li
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D000789:Angina, Unstable / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D016017:Odds Ratio; D015995:Prevalence; D011379:Prognosis; D011506:Proteins / Q000032:analysis*; D012307:Risk Factors; D012720:Severity of Illness Index; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; C512356:C1QTNF1 protein, human; D011506:Proteins
keywords: Acute myocardial infarction; Complement C1q tumor necrosis factor related protein 1; Coronary artery disease