title: Gums' based delivery systems: Review on cashew gum and its derivatives.
abstract: The development of delivery systems using natural polymers such as gums offers distinct advantages, such as, biocompatibility, biodegradability, and cost effectiveness. Cashew gum (CG) has rheological and mucoadhesive properties that can find many applications, among which the design of delivery systems for drugs and other actives such as larvicide compounds. In this review CG is characterized from its source through to the process of purification and chemical modification highlighting its physicochemical properties and discussing its potential either for micro and nanoparticulate delivery systems. Chemical modifications of CG increase its reactivity towards the design of delivery systems, which provide a sustained release effect for larvicide compounds. The purification and, the consequent characterization of CG either original or modified are of utmost importance and is still a continuing challenge when selecting the suitable CG derivative for the delivery of larvicide compounds.
authors.affiliation: Faculdade de Farmácia, Universidade de Coimbra, 3000-548 Coimbra, Portugal; I3S, Instituto de Investigação e Inovação em Saúde, IBMC-Instituto de Biologia Molecular e Celular, Genetics of Cognitive Dysfunction, Rua do Campo Alegre 823, 4150-180 Porto, Portugal. Electronic address: aribeiro@ff.uc.pt.
authors.forename: António J
authors.initials: AJ
authors.lastname: Ribeiro
authors.affiliation: Núcleo de Controle de Qualidade de Medicamentos e Correlatos-NCQMC, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco-UFPE, Brazil.
authors.forename: Flávia R Lucena
authors.initials: FRL
authors.lastname: de Souza
authors.affiliation: Núcleo de Controle de Qualidade de Medicamentos e Correlatos-NCQMC, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco-UFPE, Brazil.
authors.forename: Janira M N A
authors.initials: JMNA
authors.lastname: Bezerra
authors.affiliation: Faculdade de Farmácia, Universidade de Coimbra, 3000-548 Coimbra, Portugal; I3S, Instituto de Investigação e Inovação em Saúde, IBMC-Instituto de Biologia Molecular e Celular, Genetics of Cognitive Dysfunction, Rua do Campo Alegre 823, 4150-180 Porto, Portugal.
authors.forename: Claudia
authors.initials: C
authors.lastname: Oliveira
authors.affiliation: Núcleo de Controle de Qualidade de Medicamentos e Correlatos-NCQMC, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco-UFPE, Brazil.
authors.forename: Daniela
authors.initials: D
authors.lastname: Nadvorny
authors.affiliation: Núcleo de Controle de Qualidade de Medicamentos e Correlatos-NCQMC, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco-UFPE, Brazil.
authors.forename: Monica F
authors.initials: MF
authors.lastname: de La Roca Soares
authors.affiliation: Laboratório Interdisciplinar de Materiais Avançados-LIMAV, Centro de Ciências da Natureza-CCN, Universidade Federal do Piauí-UFPI, Brazil.
authors.forename: Lívio C C
authors.initials: LCC
authors.lastname: Nunes
authors.affiliation: Laboratório Interdisciplinar de Materiais Avançados-LIMAV, Centro de Ciências da Natureza-CCN, Universidade Federal do Piauí-UFPI, Brazil.
authors.forename: Edson C
authors.initials: EC
authors.lastname: Silva-Filho
authors.affiliation: CNC.IBILI, Universidade de Coimbra, 3000-548 Coimbra, Portugal; Faculdade de Farmácia, Universidade de Coimbra, 3000-548 Coimbra, Portugal.
authors.forename: Francisco
authors.initials: F
authors.lastname: Veiga
authors.affiliation: Núcleo de Controle de Qualidade de Medicamentos e Correlatos-NCQMC, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco-UFPE, Brazil.
authors.forename: José L
authors.initials: JL
authors.lastname: Soares Sobrinho
mesh_terms: D031021:Anacardium / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D053149:Plant Gums / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D004337:Drug Carriers; D053149:Plant Gums
keywords: Cashew gum; Chemical derivatives; Delivery system; Physicochemical properties; Purification; Submicron particle