title: Identification of a novel HLA-A allele, HLA-A*01:195, in a UAE national.
abstract: A novel human leucocyte antigen (HLA)-A allele, HLA-A*01:195, was identified by sequence-based typing (SBT) in a UAE national subject. The novel allele is identical to its closest known allele, HLA-A*01:01:01:01, in exon 2, 3 and 4, except for a single nucleotide mutation of A to G at position 442 in exon 3 (codon 124 in the α2 domain of the α chain of the mature protein). This A to G mutation results in an amino acid change of isoleucine #124 to valine.
authors.affiliation: Department of Biomedical Engineering, Khalifa University, Abu Dhabi, United Arab Emirates.
authors.forename: Wael
authors.initials: W
authors.lastname: Abdrabou
authors.affiliation: Department of Biomedical Engineering, Khalifa University, Abu Dhabi, United Arab Emirates.
authors.forename: Ini-Isabée
authors.initials: II
authors.lastname: Witzel
authors.affiliation: Transplant Diagnostics, Thermo Fischer Scientific, Hennigsdorf, Germany.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Paduch
authors.affiliation: Centre for Forensic Science, University of Western Australia, Crawley, Perth, Australia.
authors.forename: Guan
authors.initials: G
authors.lastname: Tay
authors.affiliation: Department of Biomedical Engineering, Khalifa University, Abu Dhabi, United Arab Emirates; Khalifa University Center of Biotechnology, Khalifa University of Science, Technology & Research, Abu Dhabi, United Arab Emirates. Electronic address: Habiba.Alsafar@kustar.ac.ae.
authors.forename: Habiba
authors.initials: H
authors.lastname: Alsafar
mesh_terms: D000483:Alleles; D001483:Base Sequence; D005006:Ethnicity; D005091:Exons / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D014479:United Arab Emirates
chemical_list: D015234:HLA-A Antigens
keywords: Arab genetics; HLA-A*01:195; Novel HLA-A allele; Sequence based typing