title: [Growth hormone treatment in small for gestational age children in Spain].
abstract: BACKGROUND
  Since its approval by the European Medicines Agency, a great number of patients born small for gestational date have received recombinant growth hormone treatment in Spain. The aim of this study is to analyse its outcome in the setting of ordinary clinical practice.
  
  
  METHODS
  Information was gathered from the registers of the assessment boards that authorise all growth hormone treatments prescribed in public hospitals in six autonomic communities (regions).
  
  
  RESULTS
  Valid data from 974 patients was obtained. All of them complied with criteria established by the European Medicines Agency. Patients in the sample were smaller in length than weight at birth, with their median target height being below 1 standard deviation (SD), and 23% of them had been delivered prematurely. Treatment was started at 7.2±2.8 years (mean±SD). The mean patient height at start was -3.1±0.8 SD. They gained 0.7±0.2 SD in the first year, and 1.2±0.8 SD after two years. Final height was attained by 8% of the sample, reaching -1.4±0.7 SD.
  
  
  CONCLUSIONS
  These results are similar to other Spanish and international published studies, and are representative of the current practice in Spain. Despite treatment being started at a late age, adequate growth is observed in the short term and in the final height. Up to a 24% of patients show a poor response in the first year.
authors.affiliation: Unidad de Endocrinología, Servicio de Pediatría, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, España. Electronic address: jmrial53@gmail.com.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Rial Rodríguez
authors.affiliation: Unidad de Endocrinología Pediátrica, Hospital Universitario Miguel Servet, Zaragoza, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: de Arriba Muñoz
authors.affiliation: Unidad de Endocrinología Pediátrica, Hospital Universitari Arnau de Vilanova, Universidad de Lleida, Lleida, España.
authors.forename: Jordi
authors.initials: J
authors.lastname: Bosch Muñoz
authors.affiliation: Unidad de Endocrinología Pediátrica, Crecimiento y Adolescencia, Departamento de Pediatría, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, España.
authors.forename: Paloma
authors.initials: P
authors.lastname: Cabanas Rodríguez
authors.affiliation: Unidad de Endocrinología Pediátrica, Hospital Universitario Reina Sofía, Córdoba, España.
authors.forename: Ramón
authors.initials: R
authors.lastname: Cañete Estrada
authors.affiliation: Unidad de Endocrinología Pediátrica, OSI-Araba. Hospital Universitario Araba, Departamento de Pediatría, Universidad del País Vasco, Vitoria, Álava, España.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Díez López
authors.affiliation: Servicio de Pediatría, Hospital Infanta Sofía, San Sebastián de los Reyes, Madrid, España.
authors.forename: María Magdalena
authors.initials: MM
authors.lastname: Hawkins Solís
authors.affiliation: Unidad de Endocrinología Pediátrica, Hospital Materno-Infantil Carlos Haya, Málaga, España.
authors.forename: María José
authors.initials: MJ
authors.lastname: Martínez-Aedo Ollero
authors.affiliation: Unidad de Endocrinología Pediátrica, Hospital San Agustín, Avilés, Asturias, España.
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Rodríguez Dehli
authors.affiliation: Unidad de Endocrinología, Hospital Sant Joan de Déu, Universidad de Barcelona, Barcelona, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, España.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Ibáñez Toda
mesh_terms: D000293:Adolescent; D001827:Body Height; D002648:Child; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D013030:Spain
chemical_list: D019382:Human Growth Hormone
keywords: Growth hormone; Hormona de crecimiento; Hospitales públicos; Pequeño para la edad gestacional; Public hospitals; Respuesta terapéutica; Small for gestational age; Treatment outcome