title: Validation of a New Minimally Invasive Intracranial Pressure Monitoring Method by Direct Comparison with an Invasive Technique.
abstract: In this chapter we present in vivo experiments with a new minimally invasive method of monitoring intracranial pressure (ICP). Strain gauge deformation sensors are externally glued onto the exposed skull. The signal from these sensors is amplified, filtered, and sent to a computer with appropriate software for analysis and data storage. Saline infusions into the spinal channel of rats were performed to produce ICP changes, and minimally invasive ICP and direct Codman intraparenchymal ICP were simultaneously acquired in six animals. The similarity between the invasive and minimally invasive methods in response to ICP increase was assessed using Pearson's correlation coefficient. It demonstrated good agreement between the two measures < r > = 0.8 ± 0.2, with a range of 0.31-0.99.
authors.affiliation: University of São Paulo, Sao Paulo, Brazil.|SAPRA Assessoria, Sao Carlos, Brazil.
authors.forename: Gustavo Henrique Frigieri
authors.initials: GH
authors.lastname: Vilela
authors.affiliation: University of São Paulo, Sao Paulo, Brazil.|SAPRA Assessoria, Sao Carlos, Brazil.
authors.forename: Brenno
authors.initials: B
authors.lastname: Cabella
authors.affiliation: University of São Paulo, Sao Paulo, Brazil. sergiomascarenhas28@gmail.com.
authors.forename: Sérgio
authors.initials: S
authors.lastname: Mascarenhas
authors.affiliation: Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
authors.forename: Marek
authors.initials: M
authors.lastname: Czosnyka
authors.affiliation: Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Smielewski
authors.affiliation: University of Porto, Porto, Portugal.
authors.forename: Celeste
authors.initials: C
authors.lastname: Dias
authors.affiliation: Federal University of São Carlos, Sao Carlos, Brazil.
authors.forename: Danilo Augusto
authors.initials: DA
authors.lastname: Cardim
authors.affiliation: University of São Paulo, Sao Paulo, Brazil.
authors.forename: Yvonne Maria
authors.initials: YM
authors.lastname: Mascarenhas
authors.affiliation: University of São Paulo, Sao Paulo, Brazil.
authors.forename: Charles Chenwei
authors.initials: CC
authors.lastname: Wang
authors.affiliation: University of São Paulo, Sao Paulo, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Andrade
authors.affiliation: University of São Paulo, Sao Paulo, Brazil.
authors.forename: Koji
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: University of São Paulo, Sao Paulo, Brazil.
authors.forename: Luiza Silva
authors.initials: LS
authors.lastname: Lopes
authors.affiliation: University of São Paulo, Sao Paulo, Brazil.
authors.forename: Benedicto Oscar
authors.initials: BO
authors.lastname: Colli
mesh_terms: D000818:Animals; D004867:Equipment Design; D019586:Intracranial Hypertension / Q000175:diagnosis / Q000503:physiopathology*; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male; D008991:Monitoring, Physiologic; D051381:Rats; D017208:Rats, Wistar; D012886:Skull / Q000502:physiology / Q000503:physiopathology*
keywords: Intracranial pressure (ICP); Medical instrumentation; Minimally invasive system; Monitoring