title: Neuroimaging the brain-gut axis in patients with irritable bowel syndrome.
abstract: OBJECTIVE
  To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome (IBS).
  
  
  METHODS
  A database search for relevant literature was conducted using PubMed, Scopus and Embase in February 2015. Date filters were applied from the year 2009 and onward, and studies were limited to those written in the English language and those performed upon human subjects. The initial search yielded 797 articles, out of which 38 were pulled for full text review and 27 were included for study analysis. Investigations were reviewed to determine study design, methodology and results, and data points were placed in tabular format to facilitate analysis of study findings across disparate investigations.
  
  
  RESULTS
  Analysis of study data resulted in the abstraction of four key themes: Neurohormonal differences, anatomic measurements of brain structure and connectivity, differences in functional responsiveness of the brain during rectal distention, and confounding/correlating patient factors. Studies in this review noted alterations of glutamate in the left hippocampus (HIPP), commonalities across IBS subjects in terms of brain oscillation patterns, cortical thickness/gray matter volume differences, and neuroanatomical regions with increased activation in patients with IBS: Anterior cingulate cortex, mid cingulate cortex, amygdala, anterior insula, posterior insula and prefrontal cortex. A striking finding among interventions was the substantial influence that patient variables (e.g., sex, psychological and disease related factors) had upon the identification of neuroanatomical differences in structure and connectivity.
  
  
  CONCLUSIONS
  The field of neuroimaging can provide insight into underlying physiological differences that distinguish patients with IBS from a healthy population.
authors.affiliation: Kristen R Weaver, LeeAnne B Sherwin, Wendy A Henderson, Digestive Disorders Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, United States.
authors.forename: Kristen R
authors.initials: KR
authors.lastname: Weaver
authors.affiliation: Kristen R Weaver, LeeAnne B Sherwin, Wendy A Henderson, Digestive Disorders Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, United States.
authors.forename: LeeAnne B
authors.initials: LB
authors.lastname: Sherwin
authors.affiliation: Kristen R Weaver, LeeAnne B Sherwin, Wendy A Henderson, Digestive Disorders Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, United States.
authors.forename: Brian
authors.initials: B
authors.lastname: Walitt
authors.affiliation: Kristen R Weaver, LeeAnne B Sherwin, Wendy A Henderson, Digestive Disorders Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, United States.
authors.forename: Gail D'Eramo
authors.initials: GD
authors.lastname: Melkus
authors.affiliation: Kristen R Weaver, LeeAnne B Sherwin, Wendy A Henderson, Digestive Disorders Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, United States.
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Henderson
keywords: Brain-gut axis; Functional magnetic resonance imaging; Irritable bowel syndrome; Neuroimaging