title: Application of xenogenic acellular dermal matrix in reconstruction of oncological hypopharyngeal defects.
abstract: Acellular dermal matrix (ADM) can be used as a new membrane substitute for repairing mucosal defects. The objective of this study is to explore the effectiveness of xenogenic acellular dermal matrix (xeno-ADM) in hypopharynx reconstruction. A total of 40 patients were treated with this surgical method to reconstruct hypopharynx in our department between February 2011 and October 2012. Patients were diagnosed had hypopharyngeal cancer located at lateral and/or postpharyngeal wall. The mucosal defect size after hypopharyngeal resection was 3 × 4 cm-6 × 7 cm, and was repaired by xeno-ADM. Patients were followed up for 11-36 months. 4 patients got infected, and two developed into pharyngeal fistula. Patients regained eating function 2-5 weeks after surgery. No membrane was removed; no severe stenosis of hypopharynx was observed. All patients were successfully decannulated. The overall 3-year survival rate is 67.5 %; the 3-year disease-free rate is 47.5 %. Reconstruction of hypopharynx by xeno-ADM is proved to be a simple, safe and effective method with fewer complications.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
authors.forename: Shisheng
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China. x16y2003@aliyun.com.
authors.forename: Xinming
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
authors.forename: Qinglai
authors.initials: Q
authors.lastname: Tang
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
authors.forename: Xiangbo
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
mesh_terms: D062088:Acellular Dermis; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000601:surgery*; D064593:Heterografts; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology / Q000601:surgery; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D014945:Wound Healing
keywords: Hypopharyngeal carcinoma; Reconstruction; Surgery; Xenogeneic ADM