title: Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells.
abstract: The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.
authors.affiliation: Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. S.J.Archibald@Hull.ac.uk and Positron Emission Tomography Research Centre, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
authors.forename: Shubhanchi
authors.initials: S
authors.lastname: Nigam
authors.affiliation: Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. S.J.Archibald@Hull.ac.uk and Positron Emission Tomography Research Centre, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Burke
authors.affiliation: School of Chemistry, Newcastle University, Bedson Building, Newcastle upon Tyne, NE1 7RU, UK.
authors.forename: Laura H
authors.initials: LH
authors.lastname: Davies
authors.affiliation: Positron Emission Tomography Research Centre, University of Hull, Cottingham Road, Hull, HU6 7RX, UK and Centre for Cardiovascular and Metabolic Research, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
authors.forename: Juozas
authors.initials: J
authors.lastname: Domarkas
authors.affiliation: School of Chemistry, Newcastle University, Bedson Building, Newcastle upon Tyne, NE1 7RU, UK.
authors.forename: Jennifer F
authors.initials: JF
authors.lastname: Wallis
authors.affiliation: School of Chemistry, Newcastle University, Bedson Building, Newcastle upon Tyne, NE1 7RU, UK.
authors.forename: Paul G
authors.initials: PG
authors.lastname: Waddell
authors.affiliation: School of Biological, Biomedical and Environmental Sciences, University of Hull, Cottingham Road, HU6 7RX, UK.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Waby
authors.affiliation: Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. S.J.Archibald@Hull.ac.uk.
authors.forename: David M
authors.initials: DM
authors.lastname: Benoit
authors.affiliation: Centre for Cardiovascular and Metabolic Research, University of Hull, Cottingham Road, Hull, HU6 7RX, UK and School of Biological, Biomedical and Environmental Sciences, University of Hull, Cottingham Road, HU6 7RX, UK.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Seymour
authors.affiliation: Positron Emission Tomography Research Centre, University of Hull, Cottingham Road, Hull, HU6 7RX, UK and School of Biological, Biomedical and Environmental Sciences, University of Hull, Cottingham Road, HU6 7RX, UK.
authors.forename: Christopher
authors.initials: C
authors.lastname: Cawthorne
authors.affiliation: School of Chemistry, Newcastle University, Bedson Building, Newcastle upon Tyne, NE1 7RU, UK.
authors.forename: Lee J
authors.initials: LJ
authors.lastname: Higham
authors.affiliation: Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. S.J.Archibald@Hull.ac.uk and Positron Emission Tomography Research Centre, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Archibald
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D002460:Cell Line; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000493:pharmacokinetics; D006321:Heart / Q000187:drug effects*; D006801:Humans; D061986:MCF-7 Cells; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes