title: Cutaneous manifestations of multiple myeloma and other plasma cell proliferative disorders.
abstract: Plasma cell proliferative disorders cause rare but extremely varied dermatologic manifestations that may occur as an accompaniment to established diagnoses, or may be a first clue of an underlying neoplasm in the setting of clinical suspicion. In some instances skin lesions result from aggregation of misfolded monoclonal immunoglobulins or their fragments, as in light chain-related systemic amyloidosis. On other occasions the cutaneous lesions result from deposits of malignant plasma cells or monoclonal proteins. In still others, the dermatologic manifestations are related to antibody activity of monoclonal protein, as in many cases of cryoglobulinemia. This report provides insights into the well-recognized cutaneous manifestations associated with plasma cell disorders.
authors.affiliation: Plasma Cell Disorders Program, Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC.
authors.forename: Manisha
authors.initials: M
authors.lastname: Bhutani
authors.affiliation: Plasma Cell Disorders Program, Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC.
authors.forename: Zainab
authors.initials: Z
authors.lastname: Shahid
authors.affiliation: Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR.
authors.forename: Alicia
authors.initials: A
authors.lastname: Schnebelen
authors.affiliation: Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR.
authors.forename: Daisy
authors.initials: D
authors.lastname: Alapat
authors.affiliation: Plasma Cell Disorders Program, Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC. Electronic address: saad.usmani@carolinashealthcare.org.
authors.forename: Saad Z
authors.initials: SZ
authors.lastname: Usmani
mesh_terms: D000686:Amyloidosis / Q000473:pathology; D003449:Cryoglobulinemia / Q000473:pathology; D006801:Humans; D009101:Multiple Myeloma / Q000473:pathology*; D009196:Myeloproliferative Disorders / Q000473:pathology*; D016878:POEMS Syndrome / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology; D010954:Plasmacytoma / Q000473:pathology / Q000556:secondary; D019873:Schnitzler Syndrome / Q000473:pathology; D053718:Scleromyxedema / Q000473:pathology; D012874:Skin Diseases, Infectious / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology* / Q000556:secondary; D014973:Xanthomatosis / Q000473:pathology
keywords: Dermatologic; Myeloma; Plasma cell dyscrasias; Skin