title: Efficacy, safety and effectiveness of ondansetron compared to other serotonin-3 receptor antagonists (5-HT3RAs) used to control chemotherapy-induced nausea and vomiting: systematic review and meta-analysis.
abstract: BACKGROUND
  Chemotherapy-induced nausea and vomiting are adverse effects responsible for worsening quality of life in cancer patients. To assess the efficacy, safety and effectiveness of serotonin receptor antagonist in cancer patients undergoing chemotherapy, comparing ondansetron with granisetron, dolasetron, tropisetron and palonosetron.
  
  
  METHODS
  Systematic review and meta-analysis. The data were collected using CINAHL; CENTRAL; MEDLINE/PubMed; and LILACS databases; grey literature; and manual search. The methodological quality was assessed using the modified Jadad scale; Cochrane Collaboration's tool for assessing risk of bias in randomized clinical trials and the Newcastle-Ottawa Scale for observational studies. The search was completed in November, 2015. 26 studies were included in the meta-analysis. Ondansetron exhibited similar efficacy than granisetron and tropisetron, as well as greater efficacy than dolasetron for acute vomiting. Palonosetron exhibited greater efficacy than ondansetron for delayed nausea and acute and delayed vomiting. The comparison of granisetron with ondansetron in the cohort studies showed no difference. Expert commentary: In this review, palonosetron had increased efficiency compared with ondansetron, except in the subgroup analysis and acute nausea. Few cohort studies have been published addressing this topic.
authors.affiliation: a Basic Nursing Departament, Nursing School , Federal University of Minas Gerais , Belo Horizonte , Brazil.
authors.forename: Giovana Paula Rezende
authors.initials: GP
authors.lastname: Simino
authors.affiliation: b Social Pharmacy Departament , Faculty of Pharmacy, Federal University of Minas Gerais , Belo Horizonte , Brazil.
authors.forename: Lays Pires
authors.initials: LP
authors.lastname: Marra
authors.affiliation: c Preventive and Social Medicine, Medical School , Federal University of Minas Gerais , Belo Horizonte , Brazil.
authors.forename: Eli Iola Gurgel de
authors.initials: EI
authors.lastname: Andrade
authors.affiliation: b Social Pharmacy Departament , Faculty of Pharmacy, Federal University of Minas Gerais , Belo Horizonte , Brazil.
authors.forename: Francisco de Assis
authors.initials: Fde A
authors.lastname: Acúrcio
authors.affiliation: d Statistics Department, Exact sciencesInstitute , Federal University of Minas Gerais , Belo Horizonte , Brazil.
authors.forename: Ilka Afonso
authors.initials: IA
authors.lastname: Reis
authors.affiliation: e Department of Dentistry , Pontifical Catholic University of Minas Gerais , Belo Horizonte , Brazil.
authors.forename: Vânia Eloisa
authors.initials: VE
authors.lastname: De Araújo
authors.affiliation: f Preventive and Social Medicine. Medical School . Federal University of Minas Gerais , Belo Horizonte , Brazil.
authors.forename: Mariângela Leal
authors.initials: ML
authors.lastname: Cherchiglia
mesh_terms: D000932:Antiemetics / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy*; D009369:Neoplasms / Q000188:drug therapy; D017294:Ondansetron / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D058827:Serotonin 5-HT3 Receptor Agonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents; D058827:Serotonin 5-HT3 Receptor Agonists; D017294:Ondansetron
keywords: 5-HT3 antagonist serotonin; Chemotherapy; meta-analysis; nausea; ondansetron and granisetron; pharmacology; symptom management; systematic review; vomiting