title: Polymorphism rs2200733 at chromosome 4q25 is associated with atrial fibrillation recurrence after radiofrequency catheter ablation in the Chinese Han population.
abstract: To test polymorphisms rs2200733 (chromosome 4q25) and rs2106261 (ZFHX3) were associated with AF recurrence after catheter ablation in a Chinese Han cohort. A total of 235 AF patients who underwent catheter ablation were recruited consecutively. Two polymorphisms were amplified by polymerase chain reaction and genotyped using high resolution melting analysis. Primary endpoints for AF recurrence were defined as the time to the first recurrence of atrial tachycardia/flutter/fibrillation (AT/AF). AT/AF recurrence was observed in 76 patients (35%). Allelic analysis demonstrated that rs2200733 was strongly associated with AF recurrence after ablation (P = 0.011) and the minor allele T increased the risk for recurrence (OR = 1.715). Diameters of the right atrium as well as the left and right superior pulmonary veins (PVs) were associated with rs2200733 in different genetic models (P = 0.040, 0.047 and 0.028, respectively). No significant association was detected between rs2106261 and AT/AF recurrence after ablation or atrial/PV diameters in any models. On multivariate Cox regression analysis, only rs2200733 was an independent factor of AF recurrence after ablation (HR = 0.532, P = 0.022). In Chinese Han population, rs2200733 but not rs2106261 is associated with AT/AF recurrence after ablation. The patients with genotype TT have larger size of right atrium and superior PVs than those of CC genotype. The findings suggest that rs2200733 may play a key role in regulating proper development and differentiation of atria/PVs.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Dalian Medical University Dalian, Liaoning, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Dalian Medical University Dalian, Liaoning, China.
authors.forename: Yanzong
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Dalian Medical University Dalian, Liaoning, China.
authors.forename: Rongfeng
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Dalian Medical University Dalian, Liaoning, China.
authors.forename: Shulong
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Dalian Medical University Dalian, Liaoning, China.
authors.forename: Yingxue
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Dalian Medical University Dalian, Liaoning, China.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Yin
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Dalian Medical University Dalian, Liaoning, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Chang
authors.affiliation: Department of Cardiovascular Computed Tomography, First Affiliated Hospital of Dalian Medical University Dalian, Liaoning, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Wuhan Union Hospital Wuhan, Hubei, China.
authors.forename: Kejing
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Dalian Medical University Dalian, Liaoning, China.
authors.forename: Lianjun
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Dalian Medical University Dalian, Liaoning, China.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Xia
keywords: Atrial fibrillation; atrium; pulmonary vein; radiofrequency catheter ablation; single nucleotide polymorphism