title: The life and works of S100P - from conception to cancer.
abstract: Since its discovery in 1992, the small, 10.4 kDa calcium-binding protein S100P has gained the attention of researchers from different scientific fields due to its potential roles in both healthy and neoplastic tissues. Although not ubiquitously expressed, in tissues where it is present, S100P is associated with distinct changes in cellular behaviour. In this review we have summarized the evolutionary history of S100P, its expression and involvement in implantation and human embryonic development, as well as important functions in normal tissue and cancer. Finally, we have demonstrated its pivotal role as a potential diagnostic and therapeutic target, which opens promising avenues for further fruitful research on S100P.
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London London, UK.
authors.forename: Filip
authors.initials: F
authors.lastname: Prica
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London London, UK.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Radon
authors.affiliation: Institute of Genetic Medicine, Newcastle University Newcastle, UK.
authors.forename: Yuzhu
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London London, UK.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Crnogorac-Jurcevic
keywords: S100P; cancer; embryonic development