title: Prenatal pharmacogenomics: a promising area for research.
abstract: Clinical applications of prenatal genetic screening currently focus on detection of aneuploidy and other genetic diseases in the developing fetus. Growing evidence suggests that the fetal genome may also be informative about fetal exposures through contributions to placental transport as well as placental and fetal metabolism. Possible clinical applications of prenatal pharmacogenomic screening include prospective optimization of medication selection and dosage, as well as retrospective assessment of whether a fetus was previously exposed to significant risk. Newly available noninvasive methods of prenatal genetic screening mean that relevant fetal genotypes could be made available to obstetricians for use in management of a current pregnancy. This promising area for research merits more attention than it has thus far received.The Pharmacogenomics Journal advance online publication, 10 May 2016; doi:10.1038/tpj.2016.33.
authors.affiliation: Department of Biostatistics, University of Washington, Institute for Public Health Genetics, Seattle, WA, USA.
authors.forename: E H
authors.initials: EH
authors.lastname: Dorfman
authors.affiliation: Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.|Department of Internal Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA.
authors.forename: E Y
authors.initials: EY
authors.lastname: Cheng
authors.affiliation: Department of Pharmacy, University of Washington, Seattle, WA, USA.
authors.forename: M F
authors.initials: MF
authors.lastname: Hebert
authors.affiliation: Department of Pharmaceutics, University of Washington, Seattle, WA, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Thummel
authors.affiliation: Department of Bioethics and Humanities, University of Washington, Seattle, WA, USA.
authors.forename: W
authors.initials: W
authors.lastname: Burke
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods*; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism; D005838:Genotype; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism; D010597:Pharmacogenetics / Q000379:methods*; D000071185:Pharmacogenomic Testing; D000071184:Pharmacogenomic Variants; D010641:Phenotype; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*
chemical_list: D026901:Membrane Transport Proteins; D003577:Cytochrome P-450 Enzyme System