title: Anticoagulant and vasodilator therapy for Nicolau syndrome following intramuscular benzathine penicillin injection in a 4 year old boy.
abstract: Nicolau syndrome (NS) is a rare complication of intramuscular, intraarticular or subcutaneous injection of particular drugs leading to ischemic necrosis of the surrounding skin, soft tissue and muscular tissue. Benzathine penicilin one of the most widely used antibiotic for upper respiratory tract infections and has been rarely reported to cause NS. Here we describe a 4 year old boy with diagnosis of NS after the injection of benzathine penicillin who was successfuly treated with unfractionized heparin (enoxaparine) and pentoxifylline. The practitioners should pay attention for unnecessary use of benzathine penicillin to avoid from probable complications.
authors.affiliation: Department of Cardiovascular Surgery, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Tijen
authors.initials: T
authors.lastname: Alkan Bozkaya
authors.affiliation: Division of Neonatology, Department of Pediatrics, Istanbul Medipol University, Istanbul, Turkey. fgdemirel@medipol.edu.tr.
authors.forename: Gamze
authors.initials: G
authors.lastname: Demirel
authors.affiliation: Department of Radiology, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Tugrul
authors.initials: T
authors.lastname: Ormeci
authors.affiliation: Department of Pediatrics, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Al
authors.affiliation: Department of Physical Medicine and Rehabilitation, Istanbul Medipol University, Istanbul. Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Çakar
authors.affiliation: Division of Neonatology, Department of Pediatrics, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Tastekin
authors.affiliation: Department of Cardiovascular Surgery, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Turkoglu
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000925:Anticoagulants / Q000627:therapeutic use*; D002675:Child, Preschool; D006801:Humans; D007273:Injections, Intramuscular / Q000009:adverse effects; D008297:Male; D065148:Nicolau Syndrome / Q000188:drug therapy* / Q000209:etiology*; D010401:Penicillin G Benzathine / Q000008:administration & dosage*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D014665:Vasodilator Agents; D010401:Penicillin G Benzathine
keywords: Benzathine penicillin; Enoxaparine; Nicolau syndrome; Pentoxifylline