title: Hippocampal adult neurogenesis: Its regulation and potential role in spatial learning and memory.
abstract: Adult neurogenesis, defined here as progenitor cell division generating functionally integrated neurons in the adult brain, occurs within the hippocampus of numerous mammalian species including humans. The present review details various endogenous (e.g., neurotransmitters) and environmental (e.g., physical exercise) factors that have been shown to influence hippocampal adult neurogenesis. In addition, the potential involvement of adult-generated neurons in naturally-occurring spatial learning behavior is discussed by summarizing the literature focusing on traditional animal models (e.g., rats and mice), non-traditional animal models (e.g., tree shrews), as well as natural populations (e.g., chickadees and Siberian chipmunk).
authors.affiliation: Behavioral Science Department, Utah Valley University, Orem, UT 84058, USA. Electronic address: clieberwirth@uvu.edu.
authors.forename: Claudia
authors.initials: C
authors.lastname: Lieberwirth
authors.affiliation: Program in Molecular and Translational Medicine, School of Medicine, Huzhou University, Huzhou 313000, PR China; State Key Laboratory of Integrated Management of Pest Insects and Rodents in Agriculture, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, PR China. Electronic address: 02402@hutc.zj.cn.
authors.forename: Yongliang
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306-1270, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Integrated Management of Pest Insects and Rodents in Agriculture, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, PR China.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306-1270, USA.
authors.forename: Zuoxin
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008297:Male; D018782:Maze Learning; D051379:Mice; D055495:Neurogenesis; D009474:Neurons / Q000502:physiology; D051381:Rats; D065853:Spatial Learning / Q000502:physiology*; D065852:Spatial Memory / Q000502:physiology*
keywords: Adult neurogenesis; Food hoarding; Hippocampus; Memory; Morris water maze; Spatial learning