title: Looking back (and in)to the future: A personal reflection on 'Serotonin autoreceptor function and antidepressant drug action' (Hjorth et al., 2000).
abstract: Our article in this journal some 15 years ago focussed on the role of serotonin (5-HT) autoreceptors in the mechanism of action of antidepressant drugs. Specifically in this regard, the results were summarised of rat microdialysis studies carried out to examine: (a) the relative importance of 5-HT1Aand 5-HT1Bautoreceptors, including (b) possible regional variation, and (c) potential changes in autoreceptor responsiveness following chronic selective serotonin reuptake inhibitor administration. In the present reflection piece, I recap some of the key findings against a brief background and provide an account of their bearing within the context of subsequent endeavours in the antidepressant drug research and development field. I conclude by shortly commenting on selected topics relevant to novel, interesting advances and avenues for future research.
authors.affiliation: Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden stephan.hjorth@gu.se.
authors.forename: Stephan
authors.initials: S
authors.lastname: Hjorth
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D017660:Autoreceptors / Q000378:metabolism*; D006801:Humans; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism; D044302:Receptor, Serotonin, 5-HT1B / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D017660:Autoreceptors; D044282:Receptor, Serotonin, 5-HT1A; D044302:Receptor, Serotonin, 5-HT1B; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors
keywords: 5-HT1A; 5-HT1B; Serotonin (5-HT); antidepressants; augmentation; autoreceptors; drug development; major depressive disorder; postsynaptic receptors; selective serotonin reuptake inhibitor