title: In vivo biometric evaluation of Schlemm's canal with spectral-domain optical coherence tomography in pseuduexfoliation glaucoma.
abstract: OBJECTIVE
  To perform in vivo imaging of the Schlemm's canal (SC) with anterior segment spectral-domain optical coherence tomography [AS-spectral-domain (SD)-OCT] and also to measure its biometric parameters including the SC length and SC area in patients with pseudoexfoliation (PEX) glaucoma.
  
  
  METHODS
  Forty-one consecutive patients with PEX glaucoma and 41 age- and sex-matched normal subjects were enrolled. All subjects underwent imaging with SD-OCT. The SC length and SC area were examined in the temporal sections and measured with customized software.
  
  
  RESULTS
  The percentages of the temporal sections in which SC was observable were similar between the two groups. Mean SC length was found significantly shorter, and mean SC area was found significantly smaller in patients with PEX glaucoma than in controls (p = 0.044 and p = 0.036, respectively). Mean intra-ocular pressure (IOP) values were also similar between two groups. No significant correlations were found between SC measurements and IOP.
  
  
  CONCLUSIONS
  Anterior segment spectral-domain optical coherence tomography offers non-invasive, in vivo measurement of the SC, and it could be used for investigating the SC changes in patients with PEX glaucoma.
authors.affiliation: Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Serhat
authors.initials: S
authors.lastname: Imamoglu
authors.affiliation: Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Mehmet S
authors.initials: MS
authors.lastname: Sevim
authors.affiliation: Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Oksan
authors.initials: O
authors.lastname: Alpogan
authors.affiliation: Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Nimet Y
authors.initials: NY
authors.lastname: Ercalik
authors.affiliation: Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Esra Turkseven
authors.initials: ET
authors.lastname: Kumral
authors.affiliation: Department of Ophthalmology, Pamukkale University, Denizli, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Pekel
authors.affiliation: Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Handan
authors.initials: H
authors.lastname: Bardak
mesh_terms: D000368:Aged; D001699:Biometry; D017889:Exfoliation Syndrome / Q000175:diagnosis*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D016850:Limbus Corneae / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012590:Sclera / Q000000981:diagnostic imaging / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular
keywords: 
  OCT
  ; Schlemm's canal; glaucoma; pseudoexfoliation