title: Audit of compliance with the British Committee for Standards in Haematology (BCSH) revised guidelines for the diagnosis and assessment of treatment response of hairy cell leukemia in University Hospital Galway.
abstract: BACKGROUND
  Hairy cell leukemia (HCL) is an uncommon B cell lymphoproliferative disorder. The object of the present audit was to assess whether the investigation and management of HCL in University College Hospital Galway (UCHG) complies with the British Committee for Standards in Haematology (BCSH) guidelines.
  
  
  METHODS
  Following a review of the records in our Haematology Department, 18 cases of HCL were identified between January 2006 and October 2014.
  
  
  RESULTS
  Blood film examination had been performed in all cases. Flow cytometry of liquid material had been undertaken in 89 % (n = 16) of cases, of which only 31 % (n = 5) included all four hairy cell panel markers (CD11c, CD25, CD103, CD123). Although all initial trephine biopsies included CD20, none analyzed DBA44. Only 65 % (n = 11) of treated patients had a post-treatment bone marrow biopsy preformed.
  
  
  CONCLUSIONS
  This audit highlights areas of improvement in the diagnosis and management of HCL in UCHG, which do not currently adhere to the BCSH recommendations.
authors.affiliation: Haematology Department, Galway University Hospital, Galway, Ireland. kyra.vkennedy@gmail.com.
authors.forename: K
authors.initials: K
authors.lastname: Velazquez-Kennedy
authors.affiliation: Haematology Department, Galway University Hospital, Galway, Ireland.
authors.forename: C
authors.initials: C
authors.lastname: Crowe
authors.affiliation: Haematology Department, Galway University Hospital, Galway, Ireland.
authors.forename: B
authors.initials: B
authors.lastname: Craven
authors.affiliation: Haematology Department, Galway University Hospital, Galway, Ireland.
authors.forename: J
authors.initials: J
authors.lastname: Walsh
authors.affiliation: Haematology Department, Galway University Hospital, Galway, Ireland.
authors.forename: C
authors.initials: C
authors.lastname: Prendergast
authors.affiliation: Haematology Department, Galway University Hospital, Galway, Ireland.
authors.forename: J
authors.initials: J
authors.lastname: Krawczyk
mesh_terms: D000328:Adult; D000368:Aged; D001402:B-Lymphocytes; D005260:Female; D005434:Flow Cytometry; D019983:Guideline Adherence; D006405:Hematology; D006785:Hospitals, University; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic
keywords: Hairy cell leukemia; Hairy cell leukemia assessment of treatment response; Hairy cell leukemia diagnosis and management; Hairy cell leukemia guidelines; Hairy cell panel markers; University Hospital Galway