title: [Remission of acquired hemophilia A following radiation therapy for esophageal cancer].
abstract: Although acquired hemophilia A (AHA) often develops in patients with neoplasms, there are few reports on the efficacy of radiation therapy during the bleeding phase of AHA in the prior literature. We herein present a case of AHA experiencing remission soon after radiation therapy for esophageal cancer. A man in his seventies, who had a history of radical nephrectomy for left renal cell carcinoma, received a diagnosis of esophageal cancer. Three months later, he noticed a right thigh hematoma, and was transferred to our hospital. Laboratory data revealed a marked reduction of coagulation factor VIII (FVIII) activity at 0.9% and the inhibitor to FVIII was detected in his serum at 21.8 BU/ml. Under a diagnosis of AHA, the patient received high-dose oral prednisolone, which failed to achieve disease remission. He then underwent radiation therapy to eradicate the underlying esophageal cancer. Despite tapering of the prednisolone dosage, FVIII inhibitor declined to undetectable levels. In this case, radiation therapy for the underlying cancer was associated with achieving complete remission of AHA.
authors.affiliation: Gunma University Graduate School of Medicine, Department of Medicine and Clinical Science.
authors.forename: Kunio
authors.initials: K
authors.lastname: Yanagisawa
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Takeki
authors.initials: T
authors.lastname: Mitsui
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Noguchi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Takuma
authors.initials: T
authors.lastname: Ishizaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Handa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ieko
authors.forename: Akitada
authors.initials: A
authors.lastname: Ichinose
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nojima
mesh_terms: D000368:Aged; D004938:Esophageal Neoplasms / Q000150:complications / Q000532:radiotherapy*; D005169:Factor VIII / Q000378:metabolism; D006467:Hemophilia A / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D012074:Remission Induction; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D005169:Factor VIII