title: Application value of diffusion weighted whole body imaging with background body signal suppression in monitoring the response to treatment of bone marrow involvement in lymphoma.
abstract: To investigate the application value of diffusion weighted whole body imaging with background body signal suppression (DWIBS) in monitoring the response to treatment of bone marrow involvement in lymphoma.
  
  
  
  Twenty-one lymphoma patients with bone marrow involvement underwent 1.5 Tesla DWIBS before chemotherapy and after the second chemotherapy session (median interval, 8 weeks; range 7-11 weeks). Apparent diffusion coefficient (ADC) values of bone marrow lesions were measured before and after treatment. The difference in ADC values before and after treatment in responders and nonresponders was analyzed.
  
  
  
  Seventy-three cases of bone marrow lesions were diagnosed in 21 lymphoma patients before the treatment. After the second chemotherapy session, 18 patients (57 lesions) and 3 patients (9 lesions) were categorized into the responder and nonresponder group, respectively. The mean pretreatment ADC value of all lesions was 0.90 ± 0.39 × 10-3mm2/s, of which the mean ADC values of the responder group and nonresponder group were 0.92 ± 0.40 × 10-3mm2/s and 0.79 ± 0.29 × 10-3mm2/s, respectively (between-group difference: t = -0.94; P = 0.351). The posttreatment ADC value of the responder group significantly increased (66.39% ± 83.11%; P < 0.001) while the posttreatment ADC value of the nonresponder group slightly increased (5.32% ± 17.31%). The difference in the rate of change of ADC values in the responder and nonresponder groups before and after the treatment was significant (P < 0.05).
  
  
  
  DWIBS in combination with the measurement of ADC values enabled a good short-term response evaluation for bone marrow involvement in lymphoma. However, the pretreatment ADC value indicated no significant predictive value for responses to the treatment. J. Magn. Reson. Imaging 2016;44:1522-1529.
authors.affiliation: Department of Magnetic Resonance, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P. R. China.
authors.forename: Mengtian
authors.initials: M
authors.lastname: Sun
authors.affiliation: Department of Magnetic Resonance, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P. R. China.
authors.forename: Jingliang
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Magnetic Resonance, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P. R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Magnetic Resonance, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P. R. China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Magnetic Resonance, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P. R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Meng
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P. R. China.
authors.forename: Xiaorui
authors.initials: X
authors.lastname: Fu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016477:Artifacts; D019046:Bone Marrow Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008223:Lymphoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D059629:Signal-To-Noise Ratio; D016896:Treatment Outcome; D051598:Whole Body Imaging / Q000379:methods*; D055815:Young Adult
keywords: apparent diffusion coefficient; bone marrow involvement in lymphoma; diffusion weighted whole body imaging with background body signal suppression; monitoring the responses to treatment