title: Severe Foot Lesions in Dairy Goats Associated with Digital Dermatitis Treponemes.
abstract: Treponeme-associated foot disease has been described in cattle with digital dermatitis and sheep with contagious ovine digital dermatitis. In this study, severe foot lesions in dairy goats associated with digital dermatitis treponemes (i.e. Treponema medium, Treponema phagedenis and Treponema pedis) were characterized macroscopically, radiographically and histologically. The main macroscopic foot lesion was of extensive solar ulceration with or without exophytic papilliform hyperkeratosis. Radiographically, the distal phalanx and distal sesamoid bones were severely damaged and remodelled. Histologically, the lesion was categorized as a chronic lymphoplasmacytic, suppurative and ulcerative pododermatitis. Immunohistochemistry identified the spirochaetal microorganisms located extracellularly in the superficial horn. Study limitations mean that the treponeme bacteria could not be considered the sole or causal agents in the cases described.
authors.affiliation: Department of Veterinary Pathology, School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Wirral, UK. Electronic address: hcrosby@liverpool.ac.uk.
authors.forename: H E
authors.initials: HE
authors.lastname: Crosby-Durrani
authors.affiliation: Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool Science Park IC2, 146 Brownlow Hill, Liverpool, UK.
authors.forename: S R
authors.initials: SR
authors.lastname: Clegg
authors.affiliation: Institute of Ageing and Chronic Disease, School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Wirral, UK.
authors.forename: E
authors.initials: E
authors.lastname: Singer
authors.affiliation: Infection Biology, Institute of Infection and Global Health, University of Liverpool, Leahurst Campus, Neston, Wirral, UK.
authors.forename: J W
authors.initials: JW
authors.lastname: Angell
authors.affiliation: Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool Science Park IC2, 146 Brownlow Hill, Liverpool, UK.
authors.forename: N J
authors.initials: NJ
authors.lastname: Evans
authors.affiliation: Department of Veterinary Pathology, School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Wirral, UK; Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool Science Park IC2, 146 Brownlow Hill, Liverpool, UK.
authors.forename: S D
authors.initials: SD
authors.lastname: Carter
authors.affiliation: Department of Veterinary Pathology, School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Wirral, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Blundell
authors.affiliation: Department of Epidemiology and Population Health, Institute of Infection and Global Health, University of Liverpool, Leahurst Campus, Neston, Wirral, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Duncan
mesh_terms: D000818:Animals; D058066:Digital Dermatitis / Q000382:microbiology* / Q000473:pathology*; D015511:Goat Diseases / Q000382:microbiology* / Q000473:pathology*; D006041:Goats; D016133:Polymerase Chain Reaction; D014211:Treponemal Infections / Q000662:veterinary*
keywords: digital dermatitis; goat; treponeme