title: The self-assembly of a camptothecin-lysine nanotube.
abstract: A simple, low molecular weight camptothecin-lysine conjugate is reported to self-assemble into nanotubes with diameters of 70-100nm and a drug loading level of 60.5%. The nanotubes exhibited promising in vitro cytotoxicity against cancer cell lines A549, NCI-H460 and NCI-H23. The release of active camptothecin was highly dependent on conjugate concentration, temperature and pH of the solution.
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, OH 43210, USA.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, OH 43210, USA.
authors.forename: Aileen
authors.initials: A
authors.lastname: Shieh
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, OH 43210, USA.
authors.forename: Se Hye
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, OH 43210, USA.
authors.forename: Samantha
authors.initials: S
authors.lastname: King
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, OH 43210, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Kim
authors.affiliation: Department of Molecular Virology Immunology and Medical Genetics, The Ohio State University, 460 W. 12th Ave., Columbus, OH 43210, USA.
authors.forename: Hui-Lung
authors.initials: HL
authors.lastname: Sun
authors.affiliation: Department of Molecular Virology Immunology and Medical Genetics, The Ohio State University, 460 W. 12th Ave., Columbus, OH 43210, USA.
authors.forename: Carlo M
authors.initials: CM
authors.lastname: Croce
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, OH 43210, USA.
authors.forename: Jon R
authors.initials: JR
authors.lastname: Parquette
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002166:Camptothecin / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008239:Lysine / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D043942:Nanotubes / Q000737:chemistry*; D010316:Particle Size; D013329:Structure-Activity Relationship; D013696:Temperature
chemical_list: D000970:Antineoplastic Agents; D008239:Lysine; D002166:Camptothecin
keywords: Cytotoxicity; Drug delivery; Nanoparticle; Nanotube; Self-assembly