title: Clinical Scenarios in Acute Kidney Injury: Pre-Renal Acute Kidney Injury.
abstract: Approximately 70% of community-acquired cases of acute kidney injury are attributed to pre-renal causes. In most of these cases, the underlying kidney function may be normal, but decreased renal perfusion associated with low intravascular volume or decreased arterial pressure can determine a reduced glomerular filtration rate (GFR). Autoregulatory mechanisms can partially compensate renal perfusion reduction in order to maintain GFR. In patients with pre-existing chronic kidney disease, however, these mechanisms are impaired, and the susceptibility to develop acute-on-chronic renal failure is higher.
authors.forename: Mario
authors.initials: M
authors.lastname: Meola
authors.forename: Federico
authors.initials: F
authors.lastname: Nalesso
authors.forename: Ilaria
authors.initials: I
authors.lastname: Petrucci
authors.forename: Sara
authors.initials: S
authors.lastname: Samoni
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D062186:Arterial Pressure; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology