title: Analysis of Plasma Protein Concentrations and Enzyme Activities in Cattle within the Ex-Evacuation Zone of the Fukushima Daiichi Nuclear Plant Accident.
abstract: The effect of the Fukushima Daiichi Nuclear Power Plant (FNPP) accident on humans and the environment is a global concern. We performed biochemical analyses of plasma from 49 Japanese Black cattle that were euthanized in the ex-evacuation zone set within a 20-km radius of FNPP. Among radionuclides attributable to the FNPP accident, germanium gamma-ray spectrometry detected photopeaks only from 134Cs and 137Cs (radiocesium) commonly in the organs and in soil examined. Radioactivity concentration of radiocesium was the highest in skeletal muscles. Assuming that the animal body was composed of only skeletal muscles, the median of internal dose rate from radiocesium was 12.5 μGy/day (ranging from 1.6 to 33.9 μGy/day). The median of external dose rate calculating from the place the cattle were caught was 18.8 μGy/day (6.0-133.4 μGy/day). The median of internal and external (total) dose rate of the individual cattle was 26.9 μGy/day (9.1-155.1 μGy/day). Plasma levels of malondialdehyde and superoxide dismutase activity were positively and glutathione peroxidase activity was negatively correlated with internal dose rate. Plasma alanine transaminase activity and percent activity of lactate dehydrogenase (LDH)-2, LDH-3 and LDH-4 were positively and LDH-1 was negatively correlated with both internal and total dose rate. These suggest that chronic exposure to low-dose rate of ionizing radiation induces slight stress resulting in modified plasma protein and enzyme levels.
authors.affiliation: Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan.|Fukushima Project Headquarters, National Institute of Radiological Sciences, Chiba, Chiba, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Urushihara
authors.affiliation: School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan.
authors.forename: Koh
authors.initials: K
authors.lastname: Kawasumi
authors.affiliation: Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Endo
authors.affiliation: Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Hirakawa
authors.affiliation: Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan.
authors.forename: Gohei
authors.initials: G
authors.lastname: Hayashi
authors.affiliation: Institute for Excellence in Higher Education, Tohoku University, Sendai, Miyagi, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sekine
authors.affiliation: Graduate School of Science, Tohoku University, Sendai, Miyagi, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kino
authors.affiliation: Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kuwahara
authors.affiliation: Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan.
authors.forename: Motoi
authors.initials: M
authors.lastname: Fukumoto
authors.affiliation: Faculty of Agriculture, Niigata University, Niigata, Niigata, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Yamashiro
authors.affiliation: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Abe
authors.affiliation: Graduate School of Agricultural Sciences, Tohoku University, Sendai, Miyagi, Japan.
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Fukuda
authors.affiliation: Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shinoda
authors.affiliation: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Isogai
authors.affiliation: School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Arai
authors.affiliation: Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Fukumoto
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002417:Cattle; D062406:Fukushima Nuclear Accident; D011829:Radiation Dosage
chemical_list: D001798:Blood Proteins