title: Polyionic complex of single-walled carbon nanotubes and PEG-grafted-hyperbranched polyethyleneimine (PEG-PEI-SWNT) for an improved doxorubicin loading and delivery: development and in vitro characterization.
abstract: To take advantages of single-walled carbon nanotubes (SWNTs) for cellular delivery of chemotherapeutic agents (e.g. doxorubicin) in order to decrease general toxicities of doxorubicin (DOX) and to promote the efficacy, we aimed to develop a novel approach to stabilize SWNTs through consequent steps of oxidation and PEG-g-PEI polyionic complexation (PEG-PEI-SWNT). The DOX loading capacity of modified SWNTs was about 900%. Moreover, it showed an enhanced dispersibility in physiologic-stimulated medium. DOX release was prolonged, independent of dilution, and exhibited an acidic pH-stimulated release. Therefore, PEG-PEI-SWNT could be used for cancer chemotherapy in vivo.
authors.affiliation: a Department of Pharmaceutical Nanotechnology, Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Fakhrossadat
authors.initials: F
authors.lastname: Farvadi
authors.affiliation: b Center for Nanotechnology in Drug Delivery and School of Pharmacy , Department of Pharmaceutical Nanotechnology, Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: AliMohammad
authors.initials: A
authors.lastname: Tamaddon
authors.affiliation: c Department of Pharmaceutics, School of Pharmacy , Shiraz University of Medical Science , Shiraz , Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Sobhani
authors.affiliation: a Department of Pharmaceutical Nanotechnology, Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Samira Sadat
authors.initials: SS
authors.lastname: Abolmaali
mesh_terms: D004317:Doxorubicin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000031:analogs & derivatives* / Q000737:chemistry; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D037742:Nanotubes, Carbon; C544016:poly(ethylene glycol)-co-poly(ethyleneimine); D011092:Polyethylene Glycols; D004317:Doxorubicin; D011094:Polyethyleneimine
keywords: Cancer therapy; PEG-grafted polyethyleneimine; carbon nanotube; doxorubicin; polyionic complexation