title: [MOLECULAR ASPECTS OF BRUCELLA PERSISTENCE].
abstract: Brucellosis is a dangerous zoonotic disease of animals and humans caused by bacteria of the genus Brucella, which are able to survive, multiply, and persist in host cells. The review is devoted to the Brucella species persistence connected to the molecular mechanisms of escape from innate and adaptive immunity of the host and active interaction of effector proteins of the type IV secretion system with the host's signaling pathways. Understanding of the molecular mechanisms used by Brucella for the intracellular persistence in the host organism can allow us to develop new and effective means for the prevention and treatment of chronic brucellosis infection.
authors.lastname: Kulakov Yu K
mesh_terms: D000818:Animals; D002002:Brucella / Q000235:genetics* / Q000472:pathogenicity*; D002006:Brucellosis / Q000235:genetics*; D019143:Evolution, Molecular; D006801:Humans