title: Inflammatory and oxidative stress in rotavirus infection.
abstract: Rotaviruses are the single leading cause of life-threatening diarrhea affecting children under 5 years of age. Rotavirus entry into the host cell seems to occur by sequential interactions between virion proteins and various cell surface molecules. The entry mechanisms seem to involve the contribution of cellular molecules having binding, chaperoning and oxido-reducing activities. It appears to be that the receptor usage and tropism of rotaviruses is determined by the species, cell line and rotavirus strain. Rotaviruses have evolved functions which can antagonize the host innate immune response, whereas are able to induce endoplasmic reticulum (ER) stress, oxidative stress and inflammatory signaling. A networking between ER stress, inflammation and oxidative stress is suggested, in which release of calcium from the ER increases the generation of mitochondrial reactive oxygen species (ROS) leading to toxic accumulation of ROS within ER and mitochondria. Sustained ER stress potentially stimulates inflammatory response through unfolded protein response pathways. However, the detailed characterization of the molecular mechanisms underpinning these rotavirus-induced stressful conditions is still lacking. The signaling events triggered by host recognition of virus-associated molecular patterns offers an opportunity for the development of novel therapeutic strategies aimed at interfering with rotavirus infection. The use of N-acetylcysteine, non-steroidal anti-inflammatory drugs and PPARγ agonists to inhibit rotavirus infection opens a new way for treating the rotavirus-induced diarrhea and complementing vaccines.
authors.affiliation: Carlos A Guerrero, Orlando Acosta, Department of Physiological Sciences, Faculty of Medicine, Universidad Nacional de Colombia, Bogotá 111311, Colombia.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Guerrero
authors.affiliation: Carlos A Guerrero, Orlando Acosta, Department of Physiological Sciences, Faculty of Medicine, Universidad Nacional de Colombia, Bogotá 111311, Colombia.
authors.forename: Orlando
authors.initials: O
authors.lastname: Acosta
keywords: Anti-inflammatory treatment; Antioxidant treatment; Inflammatory signaling; Oxidative stress; Rotaviruses