title: [Early predictors of necrotizing pneumonia in children].
abstract: OBJECTIVE
  To investigate the early predictors of necrotizing pneumonia in children.
  
  
  METHODS
  The clinical data of 43 children with necrotizing pneumonia and 83 children with lobar pneumonia were retrospectively analyzed. Sex, age, the number of days with fever, laboratory examination results, and bronchoscopic findings were compared between the two groups. The multiple logistic regression analysis was used to identify the early predictors of necrotizing pneumonia.
  
  
  RESULTS
  The necrotizing pneumonia group had a higher percentage of girls than the lobar pneumonia group (P<0.05). Compared with the lobar pneumonia group, the necrotizing pneumonia group had a larger number of days with fever, a higher peripheral blood white blood cell count (WBC), a higher percentage of neutrophils (NE%), and higher serum levels of high-sensitivity C-reactive protein (hs-CRP), albumin (Alb), and lactate dehydrogenase (LDH) (P<0.05). The necrotizing pneumonia group also had higher percentages of children with a large amount of sputum bolt under a bronchoscope which needed to be removed with biopsy forceps and children with rice-water-like bronchoalveolar lavage fluid (P<0.05). The multiple logistic regression analysis showed that being a female, the presence of sputum bolt under a bronchoscope which needed to be removed with biopsy forceps, the number of days with fever, WBC, hs-CRP, and LDH were independent predictors of necrotizing pneumonia. The receiver operating characteristic curve analysis showed that the cut-off values of the latter 4 predictors were 18.5 d, 15.1×10(9)/L, 121.5 mg/L, and 353.5 U/L, respectively.
  
  
  CONCLUSIONS
  Increased WBC (≥15.1×10(9)/L), increased hs-CRP (≥121.5 mg/L), increased serum LDH (≥353.5 U/L), and the presence of sputum bolt under a bronchoscope which needs to be removed with biopsy forceps and rice-water-like bronchoalveolar lavage fluid may be the early predictors of necrotizing pneumonia in children.
authors.affiliation: Department of Pediatric Respiratory Diseases, First Hospital of Jilin University, Changchun 130021, China. songlijun191@sina.com.
authors.forename: Shuai-Shuai
authors.initials: SS
authors.lastname: Liu
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Song
authors.forename: Fan-Zheng
authors.initials: FZ
authors.lastname: Meng
authors.forename: Li
authors.initials: L
authors.lastname: Peng
authors.forename: Yu-Huan
authors.initials: YH
authors.lastname: Liu
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007958:Leukocyte Count; D016015:Logistic Models; D008297:Male; D009336:Necrosis; D011014:Pneumonia / Q000097:blood / Q000175:diagnosis*
chemical_list: D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase