title: Effects of Hypothermia and Self-Warming on Activity of Ca(2+)-Dependent Neutral Proteases in Tissues of Ground Squirrels and Rats.
abstract: Effects of hypothermia and subsequent self-warming on activity of Ca(2+)-dependent neutral proteases were studied in tissues of ground squirrels and rats. Moderate hypothermia did not significantly change activity of Ca(2+)-dependent neutral proteases in the analyzed tissues of ground squirrels, but reduced protease activity in rat heart. Severe hypothermia reduced enzyme activity in the analyzed tissues of rats and ground squirrels. Differences in activity of Ca(2+)-dependent neutral proteases after long-term hypothermia and subsequent self-warming were found only in the heart.
authors.affiliation: Department of Biochemistry and Biophysics, Dagestan State University, Ministry of Education and Science of the Russian Federation, Dagestan, Russia. parizat1949@bk.ru.
authors.forename: P M
authors.initials: PM
authors.lastname: Nurmagomedova
authors.affiliation: Department of Physical and Chemical Biology, Affiliated Branch of the Southern Federal University, Ministry of Education and Science of the Russian Federation, Makhachkala, Republic of Dagestan, Russia.
authors.forename: E Z
authors.initials: EZ
authors.lastname: Emirbekov
authors.affiliation: Department of Biochemistry and Biophysics, Dagestan State University, Ministry of Education and Science of the Russian Federation, Dagestan, Russia.
authors.forename: M M
authors.initials: MM
authors.lastname: Abasova
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001921:Brain / Q000201:enzymology; D002154:Calpain / Q000378:metabolism*; D007035:Hypothermia / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology; D009928:Organ Specificity; D051381:Rats; D012589:Sciuridae; D022722:Thermogenesis
chemical_list: D002154:Calpain
keywords: Ca2+-dependent neutral proteases; calpains; ground squirrels; hypothermia; rats