title: Use of Gonadotropin-Releasing Hormone for Intractable Seizures in a Girl with Precocious Puberty without Hypothalamic Hamartoma.
abstract: The use of gonadotropin-releasing hormone analogs has been reported in the treatment of gelastic seizures and precocious puberty associated with hypothalamic hamartomas, but not in other seizure types without hypothalamic hamartoma. We describe a 7.5 year-old girl whose seizures subsided after gonadotropin-releasing hormone analog implant, administered for precocious puberty.
authors.affiliation: Positron Emission Tomography (PET) Center, Children's Hospital of Michigan, Detroit Medical Center, Detroit, MI.
authors.forename: Tuhina
authors.initials: T
authors.lastname: Govil-Dalela
authors.affiliation: Positron Emission Tomography (PET) Center, Children's Hospital of Michigan, Detroit Medical Center, Detroit, MI; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI; Department of Neurology, Wayne State University School of Medicine, Detroit, MI; Department of Radiology, Wayne State University School of Medicine, Detroit, MI.
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI; Department of Endocrinology, Wayne State University School of Medicine, Detroit, MI.
authors.forename: Kathleen C
authors.initials: KC
authors.lastname: Moltz
authors.affiliation: Positron Emission Tomography (PET) Center, Children's Hospital of Michigan, Detroit Medical Center, Detroit, MI; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI; Department of Neurology, Wayne State University School of Medicine, Detroit, MI. Electronic address: hchugani@pet.wayne.edu.
authors.forename: Harry T
authors.initials: HT
authors.lastname: Chugani
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography; D011629:Puberty, Precocious / Q000150:complications / Q000188:drug therapy*; D012640:Seizures / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants; D007987:Gonadotropin-Releasing Hormone; C029256:histrelin
keywords: GnRH; estradiol; seizures