title: The Gut Microbiota and Immune System Relationship in Human Graft-versus-Host Disease.
abstract: Gut microbiota has gained increasing interest in the pathogenesis of immune-related diseases. In this context, graft-versus-host disease is a condition characterized by an immune response which frequently complicates and limits the outcomes of hematopoietic stem cell transplantations. Past studies, carried mostly in animals, already supported a relationship between gut microbiota and graft-versus-host disease. However, the possible mechanisms underlying this connection remain elusory. Moreover, strategies to prevent graft-versus-host disease are of great interest as well as the potential role of gut microbiota modulation. We reviewed the role of gut microbiota in the development of immune system and its involvement in the graft-versus-host disease, focusing on data available on humans.
authors.affiliation: Fondazione Policlinico A. Gemelli, UOC of Internal Medicine, Gastroenterology and Liver Diseases. L.go Gemelli, 8 Rome, Italy.
authors.forename: Lucrezia
authors.initials: L
authors.lastname: Laterza
authors.affiliation: Fondazione Policlinico A. Gemelli, UOC of Internal Medicine, Gastroenterology and Liver Diseases. L.go Gemelli, 8 Rome, Italy.
authors.forename: Gianenrico
authors.initials: G
authors.lastname: Rizzatti
authors.affiliation: Fondazione Policlinico A. Gemelli, UOC of Internal Medicine, Gastroenterology and Liver Diseases. L.go Gemelli, 8 Rome, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Gaetani
authors.affiliation: Fondazione Policlinico A. Gemelli, Institute of Haematology, L.go Gemelli, 8 Rome, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Chiusolo
authors.affiliation: Fondazione Policlinico A. Gemelli, UOC of Internal Medicine, Gastroenterology and Liver Diseases. L.go Gemelli, 8 Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gasbarrini