title: [Fulminant visceral disseminated varicella-zoster virus infection without skin involvement in a patient with autoimmune hemolytic anemia on prednisolone therapy].
abstract: An 80-year-old man with autoimmune hemolytic anemia (AIHA) received immunosuppressive therapy with prednisolone (1 mg/kg). One month later, his hemoglobin level had normalized, and the prednisolone dose was tapered. The next day, he complained of acute and progressive back pain. He was admitted to our hospital for further examination approximately 24 h after the pain had started. Computed tomography revealed only localized pneumonia. However, he showed signs of severe disseminated intravascular coagulation (DIC), liver dysfunction, and respiratory failure. Empiric broad-spectrum antibacterial therapy was started with a presumptive diagnosis of severe bacterial infection. However, his condition rapidly deteriorated, and he died 17 h after admission. Varicella-zoster virus (VZV) was detected by quantitative PCR in the peripheral blood sample and by immunohistochemistry in all organs except for the brain at autopsy. Visceral VZV infection is a severe disease with a high mortality rate. Although appropriate diagnosis and treatment is crucial, in cases without the characteristic skin rash the diagnosis is difficult. The possibility of visceral VZV infection should be taken into consideration when administering prednisolone to patients with AIHA.
authors.affiliation: Department of Hematology, Tokyo Medical and Dental University.
authors.forename: Megumi
authors.initials: M
authors.lastname: Akiyama
authors.forename: Kota
authors.initials: K
authors.lastname: Yoshifuji
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Fukuda
authors.forename: Shuji
authors.initials: S
authors.lastname: Tohda
authors.forename: Tohru
authors.initials: T
authors.lastname: Miki
authors.forename: Osamu
authors.initials: O
authors.lastname: Miura
authors.forename: Masahide
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D000369:Aged, 80 and over; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000188:drug therapy*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D006562:Herpes Zoster / Q000209:etiology*; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use*
chemical_list: D011239:Prednisolone