title: STC1 and NF-κB p65 (Rel A) is Constitutively Activated in Colorectal Cancer.
abstract: BACKGROUND
  Stanniocalcin-1 (STC1) and nuclear factor (NF)-κB subunit p65 transcription factor are involved in various types of human malignancies. The roles of STC1 and NFκB-p65 in colorectal cancer (CRC) are still not fully understood. We investigated expression levels of NF-κB p65 and STC1 and also correlations between STC1 and NF-κB p65 expression and clinicopathological features in CRC.
  
  
  METHODS
  Tumor tissue samples were collected from 48 patients with CRC. RT-PCR and Real-time PCR analysis was performed to examine mRNA levels of STC1 and NF-κB p65.
  
  
  RESULTS
  The relative mRNA levels of STC1 and NF-κB p65 were significantly higher in tumor tissues than in adjacent mucosa (p = 0.025 and p = 0.044, respectively). The data also showed that STC1 and NF-κB p65 mRNA levels were not significantly associated with clinicopathological characteristics. In addition, there was no association between expression levels of STC1 and NF-κB p65 in tumor samples.
  
  
  CONCLUSIONS
  Our data indicate that STC1 and NF-κBp65 is activated constitutively in colorectal carcinoma tissues, suggesting that activation of these factors might play an important role in colorectal tumorigenesis. Future studies should examine STC1 and NF-κBp65 as a molecular target for the treatment of CRC.
authors.forename: Saleheh
authors.initials: S
authors.lastname: Rezapour
authors.forename: Tayyeb
authors.initials: T
authors.lastname: Bahrami
authors.forename: Shahryar
authors.initials: S
authors.lastname: Hashemzadeh
authors.forename: Mehrdad Asghari
authors.initials: MA
authors.lastname: Estiar
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Nemati
authors.forename: Reyhaneh
authors.initials: R
authors.lastname: Ravanbakhsh
authors.forename: Mohammad Ali Hosseinpour
authors.initials: MA
authors.lastname: Feizi
authors.forename: Hossein Samadi
authors.initials: HS
authors.lastname: Kafil
authors.forename: Nasser
authors.initials: N
authors.lastname: Pouladi
authors.forename: Morteza
authors.initials: M
authors.lastname: Ghojazadeh
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Sakhinia
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis; D051996:Transcription Factor RelA / Q000235:genetics*
chemical_list: D006023:Glycoproteins; D012333:RNA, Messenger; D051996:Transcription Factor RelA; C051795:teleocalcin