title: Colorado retinopathy of prematurity model: a multi-institutional validation study.
abstract: The Colorado retinopathy of prematurity (ROP) prediction model (CO-ROP), developed using a cohort of infants from Colorado, calls for ROP examination of infants meeting all of the following criteria: gestational age of ≤30 weeks, birth weight of ≤1500 g, and a net weight gain of ≤650 g between birth and 4 weeks of age. The purpose of this study was to perform an external validation to assess the sensitivity and specificity of the CO-ROP model in a larger cohort of babies screened for ROP from four academic institutions in the United States.
  
  
  
  The medical records of neonates screened for ROP according current national guidelines was conducted at 4 US academic centers were retrospectively reviewed. Sensitivity, specificity, and respective 95% confidence intervals in detecting ROP using CO-ROP were calculated for type 1, type 2, and any grade of ROP.
  
  
  
  A total of 858 cases were included. The CO-ROP algorithm had a sensitivity of 98.1% (95% CI, 93.3%-99.8%) for type 1 ROP, 95.6% (95% CI 78.0-99.9%) for type 2 ROP, and 95.0% (95% CI, 93.1-97.4%) for all grades of ROP. The CO-ROP model would have reduced the total number of infants screened by 23.9% compared to current 2013 screening guidelines.
  
  
  
  CO-ROP demonstrated high sensitivity in predicting ROP and would have greatly reduced the number of infants needing examination.
authors.affiliation: Department of Ophthalmology, University of Colorado, Denver; Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas. Electronic address: Jennifer.Cao@utsw.edu.
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Cao
authors.affiliation: Biostatistics and Informatics, University of Colorado, Denver.
authors.forename: Brandie D
authors.initials: BD
authors.lastname: Wagner
authors.affiliation: Department of Ophthalmology, University of Colorado, Denver.
authors.forename: Ashlee
authors.initials: A
authors.lastname: Cerda
authors.affiliation: Department of Ophthalmology, University of Colorado, Denver.
authors.forename: Emily A
authors.initials: EA
authors.lastname: McCourt
authors.affiliation: Department of Ophthalmology, University of Colorado, Denver.
authors.forename: Alan
authors.initials: A
authors.lastname: Palestine
authors.affiliation: Department of Ophthalmology, University of Colorado, Denver.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Enzenauer
authors.affiliation: Department of Ophthalmology, University of Colorado, Denver.
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Braverman
authors.affiliation: Department of Ophthalmology, University of California-Los Angeles, Los Angeles.
authors.forename: Ryan K
authors.initials: RK
authors.lastname: Wong
authors.affiliation: Department of Ophthalmology, University of California-Los Angeles, Los Angeles.
authors.forename: Irena
authors.initials: I
authors.lastname: Tsui
authors.affiliation: Ratner Children's Eye Center in the Shiley Eye Institute, University of California-San Diego, San Diego.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Gore
authors.affiliation: Ratner Children's Eye Center in the Shiley Eye Institute, University of California-San Diego, San Diego.
authors.forename: Shira L
authors.initials: SL
authors.lastname: Robbins
authors.affiliation: Department of Ophthalmology, Baylor College of Medicine, Houston, Texas.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Puente
authors.affiliation: Department of Ophthalmology, Baylor College of Medicine, Houston, Texas.
authors.forename: Levi
authors.initials: L
authors.lastname: Kauffman
authors.affiliation: Department of Ophthalmology, Baylor College of Medicine, Houston, Texas.
authors.forename: Lingkun
authors.initials: L
authors.lastname: Kong
authors.affiliation: Department of Ophthalmology, Vanderbilt University, Nashville, Tennessee.
authors.forename: David G
authors.initials: DG
authors.lastname: Morrison
authors.affiliation: Department of Ophthalmology, University of Colorado, Denver.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Lynch
mesh_terms: D000465:Algorithms; D001724:Birth Weight; D015331:Cohort Studies; D003120:Colorado; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D015233:Models, Statistical; D015997:Neonatal Screening / Q000379:methods*; D012178:Retinopathy of Prematurity / Q000175:diagnosis*; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D015430:Weight Gain