title: The Expression of the Androgen Receptor and Estrogen Receptor 1 is Related to Sex Dimorphism in the Gerbil Prostate Development.
abstract: The development of the prostate gland in females has not yet been clearly elucidated, and the sexual dimorphism associated with such gland development in general is far from being understood. In the present study, we used tridimensional (3D) reconstructions and histochemical and immunohistochemical techniques to describe the sexual dimorphism and its causes in the early postnatal development of the prostate in male and female Mongolian gerbils (Meriones unguiculatus). We observed that the female prostate was smaller, had fewer branches throughout the development, and underwent differentiation earlier than that in males. Also, the expression of the estrogen receptor 1 (ESR1 or ER-alpha) and fibroblast growth factor 10 (FGF10) was decreased in the periductal region, and the expression of the androgen receptor (AR) was increased in the epithelium. All together, these changes decreased proliferation and branching and led to an earlier prematuration of the female prostate. These new data shed light on the underlying mechanisms involved with the sexual dimorphism in the development of the prostate. Anat Rec, 299:1130-1139, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Structural and Functional Biology, State University of Campinas, Av. Bertrand Russel S/N, Campinas, São Paulo, Brazil.
authors.forename: Bruno D A
authors.initials: BD
authors.lastname: Sanches
authors.affiliation: Department of Biology, Laboratory of Microscopy and Microanalysis, Rua Cristóvão Colombo, Universal Estadual Paulista, UNESP, São José Do Rio Preto, São Paulo, Brazil.
authors.forename: Juliana S
authors.initials: JS
authors.lastname: Maldarine
authors.affiliation: Department of Biology, Laboratory of Microscopy and Microanalysis, Rua Cristóvão Colombo, Universal Estadual Paulista, UNESP, São José Do Rio Preto, São Paulo, Brazil.
authors.forename: Bruno C
authors.initials: BC
authors.lastname: Zani
authors.affiliation: Department of Structural and Functional Biology, State University of Campinas, Av. Bertrand Russel S/N, Campinas, São Paulo, Brazil.|Department of Biology, Laboratory of Microscopy and Microanalysis, Rua Cristóvão Colombo, Universal Estadual Paulista, UNESP, São José Do Rio Preto, São Paulo, Brazil.
authors.forename: Manoel F
authors.initials: MF
authors.lastname: Biancardi
authors.affiliation: Department of Morphology, Federal University of Goias, Samambaia II, Goiania, Goias, Brazil.
authors.forename: Fernanda C A
authors.initials: FC
authors.lastname: Santos
authors.affiliation: Department of Structural and Functional Biology, State University of Campinas, Av. Bertrand Russel S/N, Campinas, São Paulo, Brazil.|Department of Biology, Laboratory of Microscopy and Microanalysis, Rua Cristóvão Colombo, Universal Estadual Paulista, UNESP, São José Do Rio Preto, São Paulo, Brazil.
authors.forename: Rejane M
authors.initials: RM
authors.lastname: Góes
authors.affiliation: Department of Biology, Laboratory of Microscopy and Microanalysis, Rua Cristóvão Colombo, Universal Estadual Paulista, UNESP, São José Do Rio Preto, São Paulo, Brazil.
authors.forename: Patricia S L
authors.initials: PS
authors.lastname: Vilamaior
authors.affiliation: Department of Structural and Functional Biology, State University of Campinas, Av. Bertrand Russel S/N, Campinas, São Paulo, Brazil.|Department of Biology, Laboratory of Microscopy and Microanalysis, Rua Cristóvão Colombo, Universal Estadual Paulista, UNESP, São José Do Rio Preto, São Paulo, Brazil.
authors.forename: Sebastião R
authors.initials: SR
authors.lastname: Taboga
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D005260:Female; D005849:Gerbillinae; D007124:Immunoenzyme Techniques; D008297:Male; D038081:Organogenesis / Q000502:physiology*; D011467:Prostate / Q000254:growth & development* / Q000378:metabolism; D011944:Receptors, Androgen / Q000378:metabolism*; D012727:Sex Characteristics
chemical_list: D047628:Estrogen Receptor alpha; D011944:Receptors, Androgen
keywords: AR; ESR1; FGF10; female prostate; prostate development; sex dimorphism