title: NPGPx (GPx7): a novel oxidative stress sensor/transmitter with multiple roles in redox homeostasis.
abstract: NPGPx (GPx7) is a member of the glutathione peroxidase (GPx) family without any GPx activity. GPx7 displays a unique function which serves as a stress sensor/transmitter to transfer the signal to its interacting proteins by shuttling disulfide bonds in response to various stresses. In this review, we focus on the exceptional structural and biochemical features of GPx7 compared to other 7 family members and described how GPx7 regulates the diverse signaling targets including GRP78, PDI, CPEB2, and XRN2, and their different roles in unfolded protein response, oxidative stress, and non-targeting siRNA stress response, respectively. The phenotypes associated with GPx7 deficiency in mouse or human including ROS accumulations, highly elevated cancer incidences, auto-immune disorders, and obesity are also revealed in this paper. Finally, we compare GPx8 with GPx7, which shares the highest structural similarity but different biological roles in stress response. These insights have thus provided a more comprehensive understanding of the role of GPx7 in the maintenance of redox homeostasis.
authors.affiliation: Genomics Research Center, Academia SinicaTaipei 115, Taiwan; Graduate Program of Translational Medicine, National Taiwan UniversityTaipei 106, Taiwan.
authors.forename: Yi-Ing
authors.initials: YI
authors.lastname: Chen
authors.affiliation: Genomics Research Center, Academia Sinica Taipei 115, Taiwan.
authors.forename: Pei-Chi
authors.initials: PC
authors.lastname: Wei
authors.affiliation: Research Center for Tumor Medical Science, China Medical UniversityTaichung 404, Taiwan; Department of Medical Research, China Medical University HospitalTaichung 404, Taiwan.
authors.forename: Jye-Lin
authors.initials: JL
authors.lastname: Hsu
authors.affiliation: Genomics Research Center, Academia SinicaTaipei 115, Taiwan; Graduate Institute of Biochemistry and Molecular Biology, School of Life Sciences, National Yang-Ming UniversityTaipei 112, Taiwan.
authors.forename: Fang-Yi
authors.initials: FY
authors.lastname: Su
authors.affiliation: Genomics Research Center, Academia SinicaTaipei 115, Taiwan; Institute of Clinical Medicine, China Medical UniversityTaichung 404, Taiwan.
authors.forename: Wen-Hwa
authors.initials: WH
authors.lastname: Lee
keywords: GPx; GPx7-interactiong protein; ROS; cysteine; redox; stress