title: Independent Association between Sleep Fragmentation and Dyslipidemia in Patients with Obstructive Sleep Apnea.
abstract: Obstructive sleep apnea (OSA) is independently associated with dyslipidemia. Previous studies have demonstrated that sleep fragmentation can impair lipid metabolism. The present study aimed to identify whether sleep fragmentation is independently associated with dyslipidemia, in a large-scale, clinic-based consecutive OSA sample. This cross-sectional study was conducted among 2,686 patients who underwent polysomnography (PSG) for suspicion of OSA from January 2008 to January 2013 at the sleep laboratory. Multivariate regression analyses were performed to evaluate the independent associations between the microarousal index (MAI) and lipid profiles adjusting for potential confounders, including metabolic syndrome components and nocturnal intermittent hypoxia. The adjusted odds ratios (ORs) for various types of dyslipidemia according to MAI quartiles, as determined by logistic regression were also evaluated. MAI was found positively associated with low-density lipoprotein cholesterol (LDL-c) but not with total cholesterol (TC), triglyceride (TG) or high-density lipoprotein cholesterol (HDL-c). Furthermore, the adjusted ORs (95% confidence interval) for hyper-LDL cholesterolemia increased across MAI quartiles, as follows: 1 (reference), 1.3 (1.1-1.7), 1.6 (1.2-2.0), and 1.6 (1.2-2.1) (p = 0.001, linear trend). Sleep fragmentation in OSA is independently associated with hyper-LDL cholesterolemia, which may predispose patients with OSA to a higher risk of cardiovascular disease.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.|Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China.
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Qian
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.|Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Yi
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.|Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China.
authors.forename: Jianyin
authors.initials: J
authors.lastname: Zou
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.|Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Meng
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.|Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China.
authors.forename: Xulan
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.|Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China.
authors.forename: Huaming
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.|Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China.
authors.forename: Dongzhen
authors.initials: D
authors.lastname: Yu
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.|Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China.
authors.forename: Huiqun
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.|Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China.
authors.forename: Kaiming
authors.initials: K
authors.lastname: Su
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.|Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Guan
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.|Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, China.
authors.forename: Shankai
authors.initials: S
authors.lastname: Yin
mesh_terms: D000328:Adult; D001774:Blood Chemical Analysis; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000150:complications*; D012892:Sleep Deprivation / Q000150:complications* / Q000209:etiology