title: Exercise increases mitochondrial glutamate oxidation in the mouse cerebral cortex.
abstract: The present study investigated the impact of acute exercise on stimulating mitochondrial respiratory function in mouse cerebral cortex. Where pyruvate-stimulated respiration was not affected by acute exercise, glutamate respiration was enhanced following the exercise bout. Additional assessment revealed that this affect was dependent on the presence of malate and did not occur when substituting glutamine for glutamate. As such, our results suggest that glutamate oxidation is enhanced with acute exercise through activation of the malate-aspartate shuttle.
authors.affiliation: Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.|Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
authors.forename: Eric A F
authors.initials: EA
authors.lastname: Herbst
authors.affiliation: Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.|Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
authors.forename: Graham P
authors.initials: GP
authors.lastname: Holloway
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001224:Aspartic Acid / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism*; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism*; D007656:Ketoglutaric Acids / Q000378:metabolism; D008293:Malates / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000378:metabolism*; D010101:Oxygen Consumption; D010805:Physical Conditioning, Animal
chemical_list: D007656:Ketoglutaric Acids; D008293:Malates; D001224:Aspartic Acid; D018698:Glutamic Acid; C030298:malic acid; D005969:Glutamate Dehydrogenase; D001219:Aspartate Aminotransferases
keywords: brain mitochondria; cerebral cortex; cortex cérébral; exercice physique; exercise; glutamate metabolism; mitochondrie cérébrale; métabolisme du glutamate