title: 17-Hydroxyprogesterone responses to human chorionic gonadotropin are not associated with serum anti-Mullerian hormone levels among adolescent girls with polycystic ovary syndrome.
abstract: BACKGROUND
  In adult women with polycystic ovary syndrome (PCOS) 17-OHP responses to human chorionic gonadotropin (hCG) stimulation are highly variable and inversely correlated with serum anti-Mullerian hormone (AMH) levels. The objective of this study was to determine whether adolescents with PCOS exhibit similar variable 17-OHP responsiveness to hCG and whether these responses are correlated to AMH levels.
  
  
  METHODS
  In a prospective study, adolescent PCOS (n=14) and normal controls (n=10) received 25 μg of hCG, intravenously. Blood samples were obtained before and 24 h afterwards for measurement of 17-OHP and basal AMH.
  
  
  RESULTS
  Variable 17-OHP responses to hCG were observed among PCOS girls similar to that observed in adults. There was no correlation between AMH and 17-OHP responses to hCG.
  
  
  CONCLUSIONS
  Among adult and adolescent individuals with PCOS variable 17-OHP production appears to be characteristic of the disorder. In adolescent PCOS, 17-OHP responsiveness to hCG is not correlated to AMH.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Hou
authors.forename: Heidi
authors.initials: H
authors.lastname: Cook-Andersen
authors.forename: H Irene
authors.initials: HI
authors.lastname: Su
authors.forename: Rana
authors.initials: R
authors.lastname: Shayya
authors.forename: Kevin H
authors.initials: KH
authors.lastname: Maas
authors.forename: Christine M
authors.initials: CM
authors.lastname: Burt-Solorzano
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.forename: R Jeffrey
authors.initials: RJ
authors.lastname: Chang
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000097:blood*; D000293:Adolescent; D000735:Androstenedione / Q000097:blood; D054304:Anti-Mullerian Hormone / Q000097:blood*; D002140:California; D002648:Child; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000235:genetics / Q000627:therapeutic use*; D003687:Dehydroepiandrosterone / Q000097:blood; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D015203:Reproducibility of Results; D013739:Testosterone / Q000097:blood; D014768:Virginia
chemical_list: D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D011994:Recombinant Proteins; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D019326:17-alpha-Hydroxyprogesterone; D054304:Anti-Mullerian Hormone