title: Cytotoxic Activity of Lomatiol and 7-(3'-Hydroxymethyl-3'-methylallyloxy)coumarin.
abstract: 7-(3'-Hydroxymethyl-3'-methylallyloxy)coumarin, bearing a 3'-hydroxy-3'-methylallyl group as the O-side chain, and lomatiol, a lapachol derivative sharing the same structural feature, were tested for their in vitro growth inhibitory activities on six cancer cell lines using the MTT colorimetric assay, along with the respective 3',3'-dimethylallyl derivatives and unprenylated products used for comparison. Data revealed that lomatiol displayed the strongest growth inhibitory activities in vitro although not as efficient as the parent compound lapachol. The oxidized O-prenylcoumarin recorded better growth inhibitory capacities than the prenylated and unprenylated parent products
authors.forename: Serena
authors.initials: S
authors.lastname: Fiorito
authors.forename: Salvatore
authors.initials: S
authors.lastname: Genovese
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
authors.forename: Veronique
authors.initials: V
authors.lastname: Mathieu
authors.forename: Robert
authors.initials: R
authors.lastname: Kiss
authors.forename: Vito Alessandro
authors.initials: VA
authors.lastname: Taddeo
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D005956:Glucose-6-Phosphate Isomerase; D006801:Humans; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C000608395:7-(3'-hydroxymethyl-3'-methylallyloxy)coumarin; D000970:Antineoplastic Agents; D003374:Coumarins; D009285:Naphthoquinones; C000608394:lomatiol; D005956:Glucose-6-Phosphate Isomerase