title: Neurocognitive functioning in individuals with bipolar disorder and their healthy siblings: A preliminary study.
abstract: Cognitive deficits have been consistently reported in individuals with bipolar disorder (BD). The cognitive profile of siblings of individuals with BD is, however, less clearly established possibly due to the heterogeneity of neuropsychological measures used in previous studies. The aim of this exploratory study was to assess the cognitive function of siblings of individuals with BD and compare it with that of their first-degree relatives suffering with BD, and healthy controls (HC) using the Cambridge Neuropsychological Test Automated Battery (CANTAB) - a comprehensive and validated computerized cognitive battery.
  
  
  
  We recruited 23 HC (33.52±10.29 years, 8 males), 27 individuals with BD (34.26±10.19 years, 9 males, 25 BDI, 1BDII and 1 BD-NOS), and 15 of their biologically related siblings (37.47±13.15 years, 4 males). Siblings had no current or lifetime history of mental disorders. Participants performed the CANTAB and completed questionnaires assessing mood and global functioning. Multivariate analyses compared CANTAB measures across the three participant groups.
  
  
  
  Individuals with BD and their siblings were less accurate in a task of sustained attention (Rapid Visual Processing) when compared to HC. Further, individuals with BD displayed pronounced deficits in affective processing (Affective Go/No-Go) compared to HC. There were no cognitive differences between siblings and individuals with BD. After correcting for current depressive symptoms, these results did not reach statistical significance.
  
  
  
  Subthreshold depressive symptoms may be associated with reduced sustained attention in healthy siblings of BD patients. This preliminary result needs to be corroborated by large-scale, longitudinal studies assessing the relationship between cognition and mood in vulnerable individuals.
authors.affiliation: UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, UT Houston Medical School, Houston, TX, United States. Electronic address: Isabelle.E.Bauer@uth.tmc.edu.
authors.forename: Isabelle E
authors.initials: IE
authors.lastname: Bauer
authors.affiliation: UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, UT Houston Medical School, Houston, TX, United States.
authors.forename: Mon-Ju
authors.initials: MJ
authors.lastname: Wu
authors.affiliation: Cleveland Clinic, Pediatric Institute, Cleveland, OH, United States.
authors.forename: T W
authors.initials: TW
authors.lastname: Frazier
authors.affiliation: UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, UT Houston Medical School, Houston, TX, United States.
authors.forename: Benson
authors.initials: B
authors.lastname: Mwangi
authors.affiliation: UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, UT Houston Medical School, Houston, TX, United States.
authors.forename: Danielle
authors.initials: D
authors.lastname: Spiker
authors.affiliation: UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, UT Houston Medical School, Houston, TX, United States.
authors.forename: Giovana B
authors.initials: GB
authors.lastname: Zunta-Soares
authors.affiliation: UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, UT Houston Medical School, Houston, TX, United States.
authors.forename: Jair C
authors.initials: JC
authors.lastname: Soares
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000150:complications* / Q000523:psychology*; D003072:Cognition Disorders / Q000150:complications* / Q000523:psychology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D035781:Siblings / Q000523:psychology*; D011795:Surveys and Questionnaires; D013647:Task Performance and Analysis
keywords: Attention; Bipolar disorder; CANTAB; Cognitive; Endophenotype; Siblings