title: Methods for Generating Hydrogel Particles for Protein Delivery.
abstract: Proteins represent a major class of therapeutic molecules with vast potential for the treatment of acute and chronic diseases and regenerative medicine applications. Hydrogels have long been investigated for their potential in carrying and delivering proteins. As compared to bulk hydrogels, hydrogel microparticles (microgels) hold promise in improving aspects of delivery owing to their less traumatic route of entry into the body and improved versatility. This review discusses common methods of fabricating microgels, including emulsion polymerization, microfluidic techniques, and lithographic techniques. Microgels synthesized from both natural and synthetic polymers are discussed, as are a series of microgels fashioned from environment-responsive materials.
authors.affiliation: Bioengineering Program, Georgia Institute of Technology, Atlanta, GA, USA.|Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 2310 IBB Building, 315 Ferst Drive, Atlanta, GA, 30332, USA.|School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
authors.forename: Allen L
authors.initials: AL
authors.lastname: Liu
authors.affiliation: Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 2310 IBB Building, 315 Ferst Drive, Atlanta, GA, 30332, USA. andres.garcia@me.gatech.edu.|Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. andres.garcia@me.gatech.edu.
authors.forename: Andrés J
authors.initials: AJ
authors.lastname: García
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry* / Q000494:pharmacology*; D055767:Immobilized Proteins / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D020100:Hydrogels; D055767:Immobilized Proteins
keywords: Growth factor; Hydrogel; Microgel; Microparticle; PEG; PNIPAM; Protein delivery