title: Perspective: A Critical Look at the Ancillary Age-Related Eye Disease Study 2: Nutrition and Cognitive Function Results in Older Individuals with Age-Related Macular Degeneration.
abstract: A large body of literature suggests that the dietary carotenoids lutein and zeaxanthin and long-chain polyunsaturated fatty acids such as docosahexaenoic acid are related to improved cognitive function across the life span. A recent report by the Age-Related Eye Disease Study (AREDS) group appears to contradict the general findings of others in the field. In this review, we look critically at the methods, study designs, and analysis techniques used in the larger body of literature and compare them with the recent AREDS reports.
authors.affiliation: Vision Sciences and Human Biofactors Laboratory, Behavioral and Brain Sciences Program, Department of Psychology, The University of Georgia, Athens, GA bhammond@uga.edu.
authors.forename: Billy R
authors.initials: BR
authors.lastname: Hammond
authors.affiliation: Vision Sciences and Human Biofactors Laboratory, Behavioral and Brain Sciences Program, Department of Psychology, The University of Georgia, Athens, GA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Renzi-Hammond
mesh_terms: D000368:Aged; D000375:Aging; D002986:Clinical Trials as Topic; D003072:Cognition Disorders / Q000517:prevention & control*; D005227:Fatty Acids / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D014975:Lutein / Q000627:therapeutic use*; D008268:Macular Degeneration / Q000517:prevention & control*; D008297:Male; D012107:Research Design; D065146:Zeaxanthins / Q000627:therapeutic use*
chemical_list: D005227:Fatty Acids; D065146:Zeaxanthins; D014975:Lutein
keywords: AREDS; aging; cognition; long-chain polyunsaturated fatty acids; lutein/zeaxanthin