title: Hydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy.
abstract: In this study, a highly effective transmembrane delivery vehicle based on PEGylated oxidized mesoporous carbon nanosphere (oMCN@PEG) was successfully fabricated in a facile strategy. oMCN@PEG exhibited a narrow size distribution of 90 nm, excellent hydrophilicity, good biocompatibility, and a very high loading efficiency for doxorubicin (DOX). The drug system (oMCN@DOX@PEG) exhibited excellent stability under neutral pH conditions, but with dramatic releases of DOX at reduced pH conditions. Pharmacokinetics study revealed that oMCN@DOX@PEG could prolong the circulation of DOX in the blood stream. The endocytosis, cytotoxicity, and anticancer effect in vitro and in vivo of the drug-loaded nanoparticles were also evaluated. Our results showed that the nanoparticles efficiently penetrated the membrane of tumor cells, subsequently released drugs, and efficiently inhibited the growth of cancer cells both in vitro and in vivo. Especially, oMCN@DOX@PEG also exhibited significant antimetastasis effect in advanced stage of malignant cancer, improving the survival time of tumor-bearing mice. The results suggested that oMCN@PEG might be a promising anticancer drug delivery vehicle for cancer therapy.
authors.affiliation: Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China; Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, People's Republic of China.
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Xiangui
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China; Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, People's Republic of China.
authors.forename: Linzhao
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China; Department of Pharmacy, Hebei North University, Zhangjiakou, Hebei, People's Republic of China.
authors.forename: Jieqiong
authors.initials: J
authors.lastname: Zhan
authors.affiliation: Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Lan
authors.initials: L
authors.lastname: She
authors.affiliation: Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D002244:Carbon / Q000737:chemistry*; D018827:Carcinoma, Lewis Lung / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004337:Drug Carriers; D065546:Drug Liberation; D000067493:Dynamic Light Scattering; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D008810:Mice, Inbred C57BL; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000737:chemistry; D016062:Porosity; D017207:Rats, Sprague-Dawley
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011092:Polyethylene Glycols; D002244:Carbon; D004317:Doxorubicin
keywords: drug delivery; hydrophilic; mesoporous carbon nanoparticles; tumor metastasis