title: Two cases of genital neutrophilic sebaceous adenitis.
abstract: Sebaceous glands without a follicular structure are present in the eyelid margin (meibomian glands), lip, glans penis and vulva. Inflammatory disease of a sebaceous gland lacking follicles is rare, except for meibomitis. We report the first two cases of vulval sebaceous adenitis. Painful, yellowish-orange papules/nodules recurred at the vulval mucocutaneous junction or mucosa during the luteal phase of the menstrual cycle. Histopathologically, a dense neutrophilic infiltration was observed within the sebaceous ducts. In both cases, oral minocycline improved the condition. They had been treated with antiherpetic agents. It is possible that women diagnosed with recurrent genital herpes have genital neutrophilic sebaceous adenitis.
authors.affiliation: Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan. tohm@m.ehime-u.ac.jp.
authors.forename: Mikiko
authors.initials: M
authors.lastname: Tohyama
authors.affiliation: Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Sayama
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D046169:Dermoscopy; D005260:Female; D006801:Humans; D007249:Inflammation / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D008183:Luteal Phase; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage / Q000627:therapeutic use*; D009504:Neutrophils / Q000473:pathology*; D012625:Sebaceous Gland Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D012627:Sebaceous Glands / Q000000981:diagnostic imaging / Q000473:pathology; D014844:Vulva / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline
keywords: genital neutrophilic sebaceous adenitis; menstrual cycle; minocycline; recurrent genital herpes; vulva