title: The Effect of Paternal Age on Oocyte Donation Outcomes.
abstract: OBJECTIVE
  In recent decades, a trend toward delayed childbearing is noted in developed countries. Whereas the effects of maternal age on fertility, pregnancy complications, and postnatal outcomes have been thoroughly explored, consequences of advanced paternal age are less well known. Oocyte donation cycles can be used as an optimal model to analyze the association between male ageing and reproductive outcomes with minimal confounding.
  
  
  OBJECTIVE
  The purpose of this work was to summarize the updated and relevant literature dealing with the effect of paternal age on oocyte donation outcomes.
  
  
  RESULTS
  According to the available evidence from oocyte donation cycles, it seems that no significant association exists between advanced paternal age and fertility. However, this evidence is based on few studies, many of which are of low quality, yielding conflicting results. In addition, the emerging evidence clearly indicates an increased risk of adverse postnatal manifestations of pregnancies conceived by older fathers, including de novo autosomal dominant disorders, impaired neurocognitive development, and increased risk of malignancy.
  
  
  CONCLUSIONS
  This review may be of aid to medical practitioners in counseling couples on the risks of delayed childbearing.
authors.affiliation: Senior Obstetrician, Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, and Resident Physician, Genetics Institute, HaEmek Medical Center, Afula.
authors.forename: Lena
authors.initials: L
authors.lastname: Sagi-Dain
authors.affiliation: Head, Department of Obstetrics and Gynecology, Bnai Zion Medical Center.
authors.forename: Shlomi
authors.initials: S
authors.lastname: Sagi
authors.affiliation: Head, In Vitro Fertilization Division, Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
authors.forename: Martha
authors.initials: M
authors.lastname: Dirnfeld
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005298:Fertility; D006801:Humans; D008297:Male; D008875:Middle Aged; D018587:Oocyte Donation / Q000706:statistics & numerical data; D010331:Paternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012098:Reproduction / Q000502:physiology*; D043762:Reproductive Behavior / Q000502:physiology*; D013081:Sperm Motility / Q000502:physiology*