title: Management of chemotherapy-induced nausea and vomiting in patients receiving multiple-day highly or moderately emetogenic chemotherapy: role of transdermal granisetron.
abstract: Granisetron transdermal delivery system (GTDS) is the first 5-HT3 drug to be transdermally delivered and represents a convenient alternative to oral and intravenous antiemetics for the treatment of chemotherapy-induced nausea and vomiting. GTDS is effective and well tolerated in patients receiving multiple-day moderate-to-highly emetogenic chemotherapy. In this setting noninferiority studies showed similar efficacy when GTDS was compared with intravenous and oral granisetron and intravenous palonosetron. GTDS has shown good cardiovascular safety; however, special caution is needed in patients at risk for developing excessive QTc interval prolongation and arrhythmias. So far, GTDS has been investigated for intravenous prevention in comparison with granisetron and palonosetron; however, further prospects open the route to future clinical investigations.
authors.affiliation: Department of Medical & Surgical Sciences & Biotechnologies, Faculty of Pharmacy & Medicine - Polo Pontino, Sapienza University of Rome, Rome, Italy.|SIAARTI Study Group on Acute & Chronic Pain, Rome, Italy.
authors.forename: Flaminia
authors.initials: F
authors.lastname: Coluzzi
authors.affiliation: Department of Medical & Surgical Sciences & Biotechnologies, Faculty of Pharmacy & Medicine - Polo Pontino, Sapienza University of Rome, Rome, Italy.|SIAARTI Study Group on Acute & Chronic Pain, Rome, Italy.
authors.forename: Consalvo
authors.initials: C
authors.lastname: Mattia
mesh_terms: D000932:Antiemetics / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D017829:Granisetron / Q000008:administration & dosage*; D006801:Humans; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy*; D057968:Transdermal Patch; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents; D017829:Granisetron
keywords: 5-HT3 receptor antagonists; chemotherapy-induced nausea and vomiting; transdermal granisetron