title: Amyloid Structures as Biofilm Matrix Scaffolds.
abstract: Recent insights into bacterial biofilm matrix structures have induced a paradigm shift toward the recognition of amyloid fibers as common building block structures that confer stability to the exopolysaccharide matrix. Here we describe the functional amyloid systems related to biofilm matrix formation in both Gram-negative and Gram-positive bacteria and recent knowledge regarding the interaction of amyloids with other biofilm matrix components such as extracellular DNA (eDNA) and the host immune system. In addition, we summarize the efforts to identify compounds that target amyloid fibers for therapeutic purposes and recent developments that take advantage of the amyloid structure to engineer amyloid fibers of bacterial biofilm matrices for biotechnological applications.
authors.affiliation: Laboratory of Microbial Biofilms, Idab-CSIC-Universidad Pública de Navarra-Gobierno de Navarra, and Departamento Producción Agraria, Pamplona, Spain.
authors.forename: Agustina
authors.initials: A
authors.lastname: Taglialegna
authors.affiliation: Laboratory of Microbial Biofilms, Idab-CSIC-Universidad Pública de Navarra-Gobierno de Navarra, and Departamento Producción Agraria, Pamplona, Spain Navarrabiomed-Universidad Pública de Navarra, IdiSNA, Pamplona, Spain.
authors.forename: Iñigo
authors.initials: I
authors.lastname: Lasa
authors.affiliation: Laboratory of Microbial Biofilms, Idab-CSIC-Universidad Pública de Navarra-Gobierno de Navarra, and Departamento Producción Agraria, Pamplona, Spain jaione.valle@unavarra.es.
authors.forename: Jaione
authors.initials: J
authors.lastname: Valle
mesh_terms: D000682:Amyloid / Q000737:chemistry*; D001426:Bacterial Proteins / Q000502:physiology*; D018441:Biofilms / Q000254:growth & development*; D004269:DNA, Bacterial; D015964:Gene Expression Regulation, Bacterial
chemical_list: D000682:Amyloid; D001426:Bacterial Proteins; D004269:DNA, Bacterial