title: Thermal analysis of induced damage to the healthy cell during RFA of breast tumor.
abstract: Effective pre-clinical computational modeling strategies have been demonstrated in this article to enable risk free clinical application of radiofrequency ablation (RFA) of breast tumor. The present study (a) determines various optimal regulating parameters required for RFA of tumor and (b) introduces an essential clinical monitoring scheme to minimize the extent of damage to the healthy cell during RFA of tumor. The therapeutic capabilities offered by RFA of breast tumor, viz., the rise in local temperature and induced thermal damage have been predicted by integrating the bioheat transfer model, the electric field distribution model and the thermal damage model. The mathematical model has been validated with the experimental results available in the literature. The results revealed that, the effective damage of tumor volume sparing healthy tissue essentially depends on the voltage, the exposure time, the local heat distribution, the tumor stage and the electrode geometric configuration. It has been confirmed that, the assessment of damage front can accurately determine the extent of damage as compared to the thermal front. The study further evaluates the damaged healthy and tumor volumes due to RFA of different stages of breast cancer. The assessment of cell survival and damage fractions discloses the propensity of reappearance/healing of tumor cells after treatment.
authors.affiliation: Department of Mechanical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India.
authors.forename: Sundeep
authors.initials: S
authors.lastname: Singh
authors.affiliation: Mechanical and Aerospace Engineering Dept., University of California, 420 Westwood Plaza, Engineering IV, Los Angeles, CA 90095, USA.
authors.forename: Arka
authors.initials: A
authors.lastname: Bhowmik
authors.affiliation: Department of Mechanical Engineering, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India. Electronic address: ramjee.repaka@gmail.com.
authors.forename: Ramjee
authors.initials: R
authors.lastname: Repaka
mesh_terms: D000818:Animals; D001940:Breast / Q000098:blood supply / Q000473:pathology*; D001943:Breast Neoplasms / Q000098:blood supply / Q000473:pathology / Q000628:therapy*; D002417:Cattle; D048429:Cell Size; D003198:Computer Simulation; D004566:Electrodes; D004867:Equipment Design; D005260:Female; D020342:Finite Element Analysis; D006358:Hot Temperature; D006801:Humans; D008954:Models, Biological; D061208:Pulsed Radiofrequency Treatment / Q000295:instrumentation / Q000379:methods*; D013696:Temperature; D013814:Thermal Conductivity
keywords: Bioheat equation; Breast cancer; Finite element analysis; Pre-clinical modeling; Radiofrequency ablation