title: Association between selected gene polymorphisms and statin metabolism, risk of ischemic stroke and cardiovascular disorders.
abstract: Statins are increasingly widely used in primary and secondary prevention of cardiovascular disorders, including ischemic stroke. The initial studies regarded mainly coronary heart disease, but recently more attention has been paid to statin use in ischemic stroke, including primary and secondary prevention as well as the acute phase treatment. Besides their main hypolipemic activity, statins have been proved to have immunomodulating properties that are called a pleiotropic effect. Drug metabolism is under genetic influence, exemplified by the single nucleotide polymorphisms (SNPs). This also applies to statins. Pharmacogenetic studies are conducted in many disorders including stroke. The aim of this study was to review selected common genetic variants in lipid or statin metabolism-related genes and indicate associations with cardiovascular disorders, especially with ischemic stroke. We present available data of SNPs in regard to the most significant and promising proteins such as cytochrome P450, ATPase superfamily, organic anion transporter family, apolipoprotein E, lipoprotein-associated phospholipase A2, lipoprotein(a), LDLR, proprotein convertase subtilisin/kexin type 9, HMGCR, and CETP. A presentation of particular SNPs may help in future studies to aim for individual and thus more effective statin therapy in stroke patients.
authors.affiliation: Department of Neurology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kotlęga
authors.affiliation: Department of Neurology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Gołąb-Janowska
authors.affiliation: Department of Neurology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Masztalewicz
authors.affiliation: Department of Gynecology and Urogynaecology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Sylwester
authors.initials: S
authors.lastname: Ciećwież
authors.affiliation: Department of Neurology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Nowacki
mesh_terms: D002318:Cardiovascular Diseases / Q000235:genetics* / Q000517:prevention & control; D003324:Coronary Artery Disease / Q000517:prevention & control; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000378:metabolism* / Q000627:therapeutic use; D050356:Lipid Metabolism; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055502:Secondary Prevention; D020521:Stroke / Q000235:genetics* / Q000517:prevention & control
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors