title: MicroRNA Expression Profiles in Papillary Thyroid Carcinoma, Benign Thyroid Nodules and Healthy Controls.
abstract: MicroRNAs (miRNAs) represent a class of short endogenous non-coding RNAs that negatively regulate gene expression at the post-transcriptional level in many biological processes, including proliferation, differentiation, stress response and apoptosis. In this study we analyzed a set of seven miRNA molecules in sera of patients with papillary thyroid cancer, multinodular goiter and healthy controls to identify miRNA molecules that may have utility as markers for PTC. MiR-21 serum levels in the preoperative PTC and MG groups were significantly higher than the control group. Likewise, postoperative levels of miR-151-5p, miR-221 and miR-222 were significantly lower in patients with PTC. When serum miRNA levels were evaluated according to stage, postoperative levels of miR-151-5p and miR-222 were significantly lower in patients with advanced stages of the disease. The miRNA levels were also found associated with the size of the primary tumor. Our data imply that specific miRNA molecules which are differentially expressed in thyroid tumors may play role in the development of papillary thyroid carcinoma.
authors.affiliation: 1. Oncology Institute, Department of Basic Oncology, Istanbul University, Istanbul, Turkey;
authors.forename: Ebru Esin
authors.initials: EE
authors.lastname: Yoruker
authors.affiliation: 2. Cerrahpasa Faculty of Medicine, Department of Biochemistry, Istanbul University, Istanbul, Turkey;
authors.forename: Duygu
authors.initials: D
authors.lastname: Terzioglu
authors.affiliation: 3. Cerrahpasa Faculty of Medicine, Department of Surgery, Istanbul University, Istanbul, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Teksoz
authors.affiliation: 2. Cerrahpasa Faculty of Medicine, Department of Biochemistry, Istanbul University, Istanbul, Turkey;
authors.forename: Fatma Ezel
authors.initials: FE
authors.lastname: Uslu
authors.affiliation: 1. Oncology Institute, Department of Basic Oncology, Istanbul University, Istanbul, Turkey;
authors.forename: Ugur
authors.initials: U
authors.lastname: Gezer
authors.affiliation: 1. Oncology Institute, Department of Basic Oncology, Istanbul University, Istanbul, Turkey;
authors.forename: Nejat
authors.initials: N
authors.lastname: Dalay
keywords: expression; miRNA; papillary thyroid cancer.