title: Loading of atorvastatin and linezolid in β-cyclodextrin-conjugated cadmium selenide/silica nanoparticles: A spectroscopic study.
abstract: The preparation of β-cyclodextrin-conjugated cadmium selenide-silica nanoparticles, the loading of two drugs viz., Atorvastatin and linezolid in the cyclodextrin cavity, and the fluorescence energy transfer between CdSe/SiO2 nanoparticles and the drugs encapsulated in the cyclodextrin cavity are reported in this paper. IR spectroscopy, X-ray diffractometry, transmission electron microscopy, and particle size analysis by light-scattering experiment were used as the tools of characterizing the size and the crystal system of the nanoparticles. The nanoparticles fall under hexagonal system. The silica-shell containing CdSe nanoparticles were functionalized by reaction with aminoethylamino-β-cyclodextrin. Fluorescence spectra of the nanoparticles in their free and drug-encapsulated forms were studied. The FÖrster distances between the encapsulated drugs and the CdSe nanoparticles are below 3nm. The change in the FÖrster resonance energy parameters under physiological conditions may aid in tracking the release of drugs from the cavity of the cyclodextrin.
authors.affiliation: Department of Nanosciences & Technology, Karunya University, Coimbatore 641114, Tamil Nadu, India.
authors.forename: Eva Janet
authors.initials: EJ
authors.lastname: Antony
authors.affiliation: Department of Nanosciences & Technology, Karunya University, Coimbatore 641114, Tamil Nadu, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Shibu
authors.affiliation: Department of Chemistry, Karunya University, Coimbatore 641114, Tamil Nadu, India.
authors.forename: Sivaraj
authors.initials: S
authors.lastname: Ramasamy
authors.affiliation: Department of Chemistry, Karunya University, Coimbatore 641114, Tamil Nadu, India.
authors.forename: Mosae Selvakumar
authors.initials: MS
authors.lastname: Paulraj
authors.affiliation: Department of Nanosciences & Technology, Karunya University, Coimbatore 641114, Tamil Nadu, India; Department of Chemistry, Karunya University, Coimbatore 641114, Tamil Nadu, India. Electronic address: drisraelenoch@gmail.com.
authors.forename: Israel V M V
authors.initials: IV
authors.lastname: Enoch
mesh_terms: D000069059:Atorvastatin / Q000737:chemistry* / Q000378:metabolism; D019187:Cadmium Compounds / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D000067493:Dynamic Light Scattering; D031541:Fluorescence Resonance Energy Transfer; D000069349:Linezolid / Q000737:chemistry* / Q000378:metabolism; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D018036:Selenium Compounds / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D004337:Drug Carriers; D018036:Selenium Compounds; D047392:beta-Cyclodextrins; D012822:Silicon Dioxide; D000069059:Atorvastatin; C058667:cadmium selenide; D000069349:Linezolid
keywords: Atorvastatin; CdSe nanoparticles; Drug loading; FRET; Linezolid; β-cyclodextrin