title: A genetic variant in proximity to the gene LYPLAL1 is associated with lower hunger feelings and increased weight loss following Roux-en-Y gastric bypass surgery.
abstract: OBJECTIVE
  Bariatric surgery is the most efficient treatment of severe obesity. We investigated to what extent BMI- or waist-hip ratio (WHR)-related genetic variants are associated with excess BMI loss (EBMIL) two years after Roux-en-Y gastric bypass (RYGB) surgery, and elucidated the affected biological pathways.
  
  
  METHODS
  Two-hundred fifty-one obese patients (age: 43 ± 10.7, preoperative BMI: 45.1 ± 6.1 kg/m(2), 186 women) underwent RYGB surgery and were followed up after two years with regard to BMI. Patients were genotyped for 32 single-nucleotide polymorphisms (SNPs) that were investigated with regard to their impact on response to RYGB and preoperatively measured Three Factor Eating Questionnaire (TFEQ) scores.
  
  
  RESULTS
  Homozygous T carriers of the SNP rs4846567 in proximity to the Lysophospholipase-like 1 (LYPLAL1) gene showed a 7% higher EBMIL compared to wild-type and heterozygous carriers (p = 0.031). TT-allele carriers showed furthermore lower scores for Hunger (74%, p < 0.001), lower Disinhibition (53%, p < 0.001), and higher Cognitive restraint (21%, p = 0.017) than GG/GT carriers in the TFEQ. Patients within the lowest quartile of Hunger scores had a 32% greater EBMIL compared to patients in the highest quartile (p < 0.001).
  
  
  CONCLUSIONS
  The LYPLAL1 genotype is associated with differences in eating behavior and loss of extensive body weight following RYGB surgery. Genotyping and the use of eating behavior-related questionnaires may help to estimate the RYGB-associated therapy success.
authors.affiliation: a Department of Neuroscience, Functional Pharmacology , Uppsala University , Uppsala , Sweden ;
authors.forename: Marcus
authors.initials: M
authors.lastname: Bandstein
authors.affiliation: a Department of Neuroscience, Functional Pharmacology , Uppsala University , Uppsala , Sweden ;
authors.forename: Jessica
authors.initials: J
authors.lastname: Mwinyi
authors.affiliation: b Interdisciplinary Obesity Center , eSwiss Medical & Surgical Center , St. Gallen , Switzerland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Ernst
authors.affiliation: b Interdisciplinary Obesity Center , eSwiss Medical & Surgical Center , St. Gallen , Switzerland.
authors.forename: Martin
authors.initials: M
authors.lastname: Thurnheer
authors.affiliation: b Interdisciplinary Obesity Center , eSwiss Medical & Surgical Center , St. Gallen , Switzerland.
authors.forename: Bernd
authors.initials: B
authors.lastname: Schultes
authors.affiliation: a Department of Neuroscience, Functional Pharmacology , Uppsala University , Uppsala , Sweden ;
authors.forename: Helgi B
authors.initials: HB
authors.lastname: Schiöth
mesh_terms: D000328:Adult; D005247:Feeding Behavior / Q000523:psychology*; D005260:Female; D015390:Gastric Bypass; D005838:Genotype; D006801:Humans; D006815:Hunger; D016014:Linear Models; D008245:Lysophospholipase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000601:surgery*; D020641:Polymorphism, Single Nucleotide; D011795:Surveys and Questionnaires; D013557:Switzerland; D015431:Weight Loss / Q000235:genetics*
chemical_list: D008245:Lysophospholipase; C561408:LYPLAL1 protein, human
keywords: LYPLAL1; RYGB; Three Factor Eating Questionnaire; rs4846567; single nucleotide polymorphism