title: PAMAM-grafted TiO2 nanotubes as novel versatile materials for drug delivery applications.
abstract: PAMAM-grafted TiO2 nanotubes (PAMAM-TiO2NT) have been synthesized and evaluated as new drug nanocarriers, using curcumin (CUR), methotrexate (MTX), and silibinin (SIL) as model therapeutic compounds. TiO2NT were surface-modified using a silane coupling agent and subsequently conjugated with PAMAM dendrimer of the third generation. The characterization of PAMAM-TiO2NT nanomaterials was performed by FTIR, TEM, N2 adsorption-desorption isotherms, XRD, and TGA techniques, which accounted for a 2.6wt.% of PAMAM grafting in the prepared materials. The drug loading capacity, drug release properties, and cytotoxicity of PAMAM-TiO2NT showed a significant improvement compared to pristine TiO2NT, thus revealing the promising properties of these new materials for drug delivery purposes.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Concepción, Edmundo Larenas 139, Concepción, Chile.
authors.forename: Cecilia C
authors.initials: CC
authors.lastname: Torres
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Concepción, Edmundo Larenas 139, Concepción, Chile.
authors.forename: Cristian H
authors.initials: CH
authors.lastname: Campos
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Concepción, Edmundo Larenas 139, Concepción, Chile.
authors.forename: Carola
authors.initials: C
authors.lastname: Diáz
authors.affiliation: Departamento de Ciencias Químicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Sede Concepción, Autopista Concepción-Talcahuano 7100, Talcahuano, Chile.
authors.forename: Verónica A
authors.initials: VA
authors.lastname: Jiménez
authors.affiliation: Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
authors.forename: Felipe
authors.initials: F
authors.lastname: Vidal
authors.affiliation: Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Guzmán
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Concepción, Edmundo Larenas 139, Concepción, Chile. Electronic address: jalderet@udec.cl.
authors.forename: Joel B
authors.initials: JB
authors.lastname: Alderete
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D050091:Dendrimers / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006367:HeLa Cells; D006801:Humans; D008727:Methotrexate / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000378:metabolism; D000077385:Silybin; D012838:Silymarin / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D017550:Spectroscopy, Fourier Transform Infrared; D014025:Titanium / Q000737:chemistry*
chemical_list: D050091:Dendrimers; D004337:Drug Carriers; C104700:PAMAM Starburst; D004364:Pharmaceutical Preparations; D012838:Silymarin; C009495:titanium dioxide; D000077385:Silybin; D014025:Titanium; D003474:Curcumin; D008727:Methotrexate
keywords: Drug delivery; PAMAM dendrimers; Small molecule drugs; TiO(2) nanotubes