title: Continuous Monitoring of the Complexity of Intracranial Pressure After Head Injury.
abstract: Multiscale entropy (MSE) has been increasingly used to investigate the complexity of biological signals. Our previous study demonstrated that the complexity of mean intracranial pressure (ICP), assessed by MSE based on the whole recording periods, is associated with the outcome after traumatic brain injury (TBI). To improve the feasibility of MSE in a clinical setting, this study examined whether the complexity of ICP waveforms based on shorter periods could be a reliable predictor of the outcome in patients with TBI. Results showed that the complexity of ICP slow waves, calculated in 3-h moving windows, correlates with the outcome of patients with TBI. Thus, the complexity of ICP may be a promising index to be incorporated into multimodal monitoring in patients with TBI.
authors.affiliation: Department of Anaesthesiology, Far-Eastern Memorial Hospital, 21, Section 2, Nan-Ya South Road, Pan-Chiao, New Taipei City, Taiwan. drluchengwei@gmail.com.|Department of Mechanical Engineering, Yuan Ze University, Taoyuan, Taiwan. drluchengwei@gmail.com.|Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. drluchengwei@gmail.com.
authors.forename: Cheng-Wei
authors.initials: CW
authors.lastname: Lu
authors.affiliation: Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
authors.forename: Marek
authors.initials: M
authors.lastname: Czosnyka
authors.affiliation: Department of Mechanical Engineering, Yuan Ze University, Taoyuan, Taiwan.
authors.forename: Jiann-Shing
authors.initials: JS
authors.lastname: Shieh
authors.affiliation: Department of Neurosurgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
authors.forename: John D
authors.initials: JD
authors.lastname: Pickard
authors.affiliation: Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Smielewski
mesh_terms: D019540:Area Under Curve; D000070642:Brain Injuries, Traumatic / Q000150:complications / Q000628:therapy*; D019468:Disease Management; D019277:Entropy; D005240:Feasibility Studies; D006801:Humans; D019586:Intracranial Hypertension / Q000175:diagnosis* / Q000209:etiology; D007427:Intracranial Pressure; D008991:Monitoring, Physiologic / Q000379:methods*; D012372:ROC Curve; D012189:Retrospective Studies; D012815:Signal Processing, Computer-Assisted
keywords: Complexity; Intracranial pressure; Multiscale entropy; Outcome; Traumatic brain injury