title: The platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are major players in oncogenesis, drug resistance, and attractive oncologic targets in cancer.
abstract: The platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) play a key role in signaling pathways in oncogenesis. The overexpression of PDGFs and PDGFRs and the oncogenic alterations of these receptors have been implicated in human cancers and correlated significantly with poor outcomes. This review discusses the biology of the PDGF isoforms and receptors briefly, and their role in oncogenesis. Also, the attractiveness of targeting PDGFs and PDGFRs, based on a wide display of oncologic alterations in cancers, diverse therapeutic strategies, their roles in resistance to cancer treatments with prospects of overcoming drug resistance, and the extent to which validated biomarkers have been developed for effective PDGFs and PDGFRs-based cancer management are discussed.
authors.affiliation: a Department of Physiology , School of Medicine, Jiangsu University , Jiangsu , People's Republic of China .
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a Department of Physiology , School of Medicine, Jiangsu University , Jiangsu , People's Republic of China .|b Department of Applied Biology , University for Development Studies , Navrongo , Ghana , and.
authors.forename: Kwaku
authors.initials: K
authors.lastname: Appiah-Kubi
authors.affiliation: a Department of Physiology , School of Medicine, Jiangsu University , Jiangsu , People's Republic of China .
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.affiliation: c Basic Medical Department, Changchun Medical College , Jilin , People's Republic of China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Yao
authors.affiliation: a Department of Physiology , School of Medicine, Jiangsu University , Jiangsu , People's Republic of China .
authors.forename: Hai
authors.initials: H
authors.lastname: Qian
authors.affiliation: a Department of Physiology , School of Medicine, Jiangsu University , Jiangsu , People's Republic of China .
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: a Department of Physiology , School of Medicine, Jiangsu University , Jiangsu , People's Republic of China .
authors.forename: Yongchang
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D010982:Platelet-Derived Growth Factor / Q000235:genetics / Q000378:metabolism*; D017479:Receptors, Platelet-Derived Growth Factor / Q000235:genetics / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D010982:Platelet-Derived Growth Factor; D017479:Receptors, Platelet-Derived Growth Factor
keywords: PDGF isoforms; PDGF receptors; PDGFRs mutation; biomarker; cancer treatments; drug resistance