title: Role of ADAMTS5 in Unexplained Fetal Growth Restriction (FGR).
abstract: OBJECTIVE
  We aim to determine the role of serum and placental A disintegrin and metalloproteinase with thrombospondin motif 5 (ADAMTS5) in fetal growth restriction (FGR).
  
  
  METHODS
  43 pregnancies suffering FGR and 45 healthy ones were homogenized for their body mass indices, ages, and gestational weeks. Expression of ADAMTS5 in placental samples was determined by immunohistochemical methods and concurrent maternal serum ADAMTS5 levels were determined with enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Expression of ADAMTS5 was higher in FGR group than the healthy control in placenta. Both the cytoplasmic staining pattern of the syncytiotrophoblasts and staining of the decidual plate were shown in the FGR group; but not in the control group. A negative correlation between serum ADAMTS5 levels and birth weight in FGR group was observed.
  
  
  CONCLUSIONS
  Increased ADAMTS5 levels were observed in placental insufficiency cases. This study demonstrates that ADAMTS5 may be a sensitive indicator of placental insufficiency which has variable factors in etiology. Additional work is needed to delineate the mechanism of its involvement.
authors.affiliation: a Zekai Tahir Burak Women's Health Education and Research Hospital , Department of Perinatology , Ankara , Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Ozler
authors.affiliation: a Zekai Tahir Burak Women's Health Education and Research Hospital , Department of Perinatology , Ankara , Turkey.
authors.forename: Efser
authors.initials: E
authors.lastname: Oztas
authors.affiliation: b Department of Obstetrics and Gynecology , Liv Hospital , Ankara , Turkey.
authors.forename: Basak Gumus
authors.initials: BG
authors.lastname: Guler
authors.affiliation: c Ankara Branch of Council of Forensic Medicine , Ankara , Turkey.
authors.forename: Sultan
authors.initials: S
authors.lastname: Pehlivan
authors.affiliation: d Department of Obstetrics and Gynecology , Serefli Kochisar State Hospital , Ankara , Turkey.
authors.forename: Nezaket
authors.initials: N
authors.lastname: Kadioglu
authors.affiliation: e Faculty of Medicine , Department of Clinical Biochemistry, Yildirim Beyazit University , Ankara , Turkey.
authors.forename: Merve
authors.initials: M
authors.lastname: Ergin
authors.affiliation: a Zekai Tahir Burak Women's Health Education and Research Hospital , Department of Perinatology , Ankara , Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Uygur
authors.affiliation: a Zekai Tahir Burak Women's Health Education and Research Hospital , Department of Perinatology , Ankara , Turkey.
authors.forename: Nuri
authors.initials: N
authors.lastname: Danisman
mesh_terms: D000071116:ADAMTS5 Protein / Q000032:analysis / Q000096:biosynthesis*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D016017:Odds Ratio; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D000071116:ADAMTS5 Protein; C121532:ADAMTS5 protein, human
keywords: ADAMTS5; fetal growth restriction; placenta