title: Highly stable microwave susceptible agents via encapsulation of Ti-mineral superfine powders in urea-formaldehyde resin microcapsules for tumor hyperthermia therapy.
abstract: In this study, Ti-mineral superfine powders (Ti-MSP) encapsulated in urea-formaldehyde resin microcapsules (Ti-MSP@UF-MC) were successfully prepared via a one-step microemulsion method for the first time. Because of the strong confinement effects, the Ti-MSP@UF-MC possessed perfect microwave heating effects. The temperature was 9.3 °C higher than that of the saline solution, superior to UF-MC (no significant microwave heating effect, 0 °C) and Ti-MSP (5.1 °C). The Ti-MSP@UF-MC showed low toxicity and good biocompatibility via a series of studies, including a hemolysis study and the MTT assay in vitro and in vivo. When the concentration was below 1000 μg mL(-1), the hemolysis rate was lower than 5% (hemolysis study). When the concentration was below 400 μg mL(-1), the cell activity was higher than 80% (MTT assay). Moreover, the Ti-MSP@UF-MC exhibited an ideal CT imaging effect in vivo owing to the large molecular weight of Ti-MSP. The Ti-MSP@UF-MC showed a favorable microwave therapy effect in vivo. Using mice bearing H22 tumor cells as an animal model, the tumor suppression rate could reach 100%.
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China. mengxw@mail.ipc.ac.cn.
authors.forename: Dan
authors.initials: D
authors.lastname: Long
authors.forename: Jingsong
authors.initials: J
authors.lastname: Mao
authors.forename: Tianlong
authors.initials: T
authors.lastname: Liu
authors.forename: Changhui
authors.initials: C
authors.lastname: Fu
authors.forename: Longfei
authors.initials: L
authors.lastname: Tan
authors.forename: Xiangling
authors.initials: X
authors.lastname: Ren
authors.forename: Haitang
authors.initials: H
authors.lastname: Shi
authors.forename: Hongying
authors.initials: H
authors.lastname: Su
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
authors.forename: Xianwei
authors.initials: X
authors.lastname: Meng
mesh_terms: D000818:Animals; D002214:Capsules; D005260:Female; D005557:Formaldehyde / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D006979:Hyperthermia, Induced; D051379:Mice; D008813:Mice, Inbred ICR; D008872:Microwaves; D008903:Minerals / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000628:therapy*; D011208:Powders; D023382:Toxicity Tests, Acute; D014508:Urea / Q000737:chemistry*
chemical_list: D002214:Capsules; D008903:Minerals; D011208:Powders; D005557:Formaldehyde; D014508:Urea