title: APOA5 and APOA1 polymorphisms are associated with triglyceride levels in Mexican children.
abstract: Dyslipidemia is an important risk factor for the development of several diseases. The genetic component of hypertriglyceridemia has been studied in adults, but little is known in children.
  
  
  
  The objective is to evaluate the association of two variants in APOA5 (rs662799) and APOA1 (rs5072) with triglyceride (TG) levels in Mexican children.
  
  
  
  Anthropometric parameters were measured in 1559 Mexican children 5-14 years of age. DNA was isolated from blood samples. Lipid profiles and glucose concentrations were determined from serum and genotyping of rs662799, and rs5072 was performed using TaqMan® technology. Additive and dominant models adjusted for age, gender and body mass index were used to evaluate the association of these single nucleotide polymorphisms with TG levels.
  
  
  
  Children with high TG levels were found to have a higher body mass index and waist circumference as well as a worse lipids profile and glucose levels (p < 0.001). Additive and dominant models demonstrated a significant association between the rs662799 and rs5072 with TG. The dominant model showed the strongest significant association (OR = 1.81; 95% CI 1.46-2.24; p = 5.40 × 10-08for rs662799 and OR = 1.54; 95% CI 1.05-2.25; p = 2.60 × 10-02for rs5072).
  
  
  
  The minor alleles of rs662799 (APOA5) and rs5072 (APOA1) modulate TG levels in Mexican children.
authors.affiliation: Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social, Mexico City, Mexico.
authors.forename: F
authors.initials: F
authors.lastname: Suárez-Sánchez
authors.affiliation: Departamento de Investigación en Salud Comunitaria, Hospital Infantil de México Federico Gómez, Secretaria de Salud, Mexico City, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Klunder-Klunder
authors.affiliation: Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social, Mexico City, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Valladares-Salgado
authors.affiliation: Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social, Mexico City, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Gómez-Zamudio
authors.affiliation: Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social, Mexico City, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Peralta-Romero
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.|Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Meyre
authors.affiliation: Centro de Enfermedades Infecciosas, Instituto Nacional de Salud Pública, México DF, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Burguete-García
authors.affiliation: Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social, Mexico City, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Cruz
mesh_terms: D000293:Adolescent; D000483:Alleles; D000886:Anthropometry; D016632:Apolipoprotein A-I / Q000235:genetics*; D000072040:Apolipoprotein A-V / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006801:Humans; D015228:Hypertriglyceridemia / Q000208:ethnology / Q000235:genetics*; D008297:Male; D017058:Mexican Americans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: C505693:APOA1 protein, human; C437704:APOA5 protein, human; D016632:Apolipoprotein A-I; D000072040:Apolipoprotein A-V; D014280:Triglycerides
keywords: APOA1; APOA5; rs662799 and rs5072; triglycerides