title: Telomere Length of Individual Chromosomes in Patients with Rheumatoid Arthritis.
abstract: We analyzed telomere length of individual chromosomes in peripheral blood lymphocytes of healthy individuals and patients with rheumatoid arthritis. Quantitative fluorescent in situ hybridization and subsequent computer analysis of metaphase chromosomes showed that distribution of telomere length on individual chromosomes is different under normal and pathological conditions. Patients with rheumatoid arthritis had significantly shorter chromosome 4p telomeres, which can be essential for pathogenesis of this multifactorial disease. Additionally, disease activity inversely correlated with telomere length on chromosome 10p carrying genes involved in T cell differentiation and proliferation.
authors.affiliation: Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. blinovaelena-85@yandex.ru.
authors.forename: E A
authors.initials: EA
authors.lastname: Blinova
authors.affiliation: Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Zinnatova
authors.affiliation: Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: M Sh
authors.initials: MSh
authors.lastname: Barkovskaya
authors.affiliation: Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Borisov
authors.affiliation: Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Sizikov
authors.affiliation: Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Kozhevnikov
authors.affiliation: Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: N B
authors.initials: NB
authors.lastname: Rubtsov
authors.affiliation: Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Kozlov
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000473:pathology*; D016022:Case-Control Studies; D002877:Chromosomes, Human / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016615:Telomere / Q000235:genetics*; D059505:Telomere Homeostasis
keywords: chromosomes; lymphocytes; quantitative fluorescent in situ hybridization; rheumatoid arthritis; telomere length