title: Expression level of NSE, S100B and NPY in children with acute miliary phthisis and secondary tubercular meningitis.
abstract: To explore the expression level of neuron-specific enolase (NSE), S100B and neuropeptide Y (NPY) in children with acute miliary tuberculosis and secondary tubercular meningitis.
  
  
  
  28 children diagnosed with acute miliary tuberculosis and secondary tubercular meningitis were included into group A, 25 children diagnosed with pure acute miliary tuberculosis were included into group B and 23 children diagnosed with suspected meningitis were included into group C. The levels of NSE, S100B and NPY in cerebrospinal fluid and serum were detected.
  
  
  
  The levels of NSE, S100B and NPY in cerebrospinal fluid and serum of group A were significantly higher than the levels in the other two groups, differences were statistically significant (p<0.05). A multifactor retrospective analysis suggested that secondary tubercular meningitis was significantly correlated with the high expression of S100B, NPY and NSE in cerebrospinal fluid and serum.
  
  
  
  Early detection of the expression levels of NSE, S100B and NPY in cerebrospinal fluid and serum was of great value for the diagnosis of tubercular meningitis secondary to acute miliary tuberculosis.
authors.affiliation: The First Department of Tuberculosis, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China. lafhjg@163.com.
authors.forename: C-X
authors.initials: CX
authors.lastname: Zhang
authors.forename: D-J
authors.initials: DJ
authors.lastname: Zhang
authors.forename: Y-L
authors.initials: YL
authors.lastname: Wang
authors.forename: W
authors.initials: W
authors.lastname: Han
authors.forename: G-C
authors.initials: GC
authors.lastname: Shi
authors.forename: H-Q
authors.initials: HQ
authors.lastname: Zhang
mesh_terms: D015415:Biomarkers / Q000097:blood; D002648:Child; D006801:Humans; D009414:Nerve Growth Factors / Q000097:blood; D009478:Neuropeptide Y; D012189:Retrospective Studies; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D014390:Tuberculosis, Meningeal; D014391:Tuberculosis, Miliary
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D009478:Neuropeptide Y; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins