title: A possible effect of methylphenidate on state anxiety: A single dose, placebo controlled, crossover study in a control group.
abstract: Methylphenidate affects state-anxiety in ADHD patients. The current study examines the effect of Methylphenidate on state-anxiety in healthy subjects. In a cross-over, randomized, controlled, double-blind study, 36 healthy subjects received either Methylphenidate or placebo. As a group, no change in state-anxiety was detected with Methylphenidate. However, participants reporting higher anxiety levels experienced a significant and specific state-anxiety reduction following Methylphenidate. Moreover, a strong negative correlation was found between the initial-level of anxiety and net-change in state-anxiety. These changes were unrelated to self-perceived attention levels. Our results point to the state-dependent effects of Methylphenidate on anxiety.
authors.affiliation: Shalvata Mental Health Center, Hod Hasharon, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: aviv@segev.name.
authors.forename: Aviv
authors.initials: A
authors.lastname: Segev
authors.affiliation: Shalvata Mental Health Center, Hod Hasharon, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Hila Zahava
authors.initials: HZ
authors.lastname: Gvirts
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins Hospital, MD, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Strouse
authors.affiliation: Department of Psychology, University of Haifa, Haifa, Israel.
authors.forename: Naama
authors.initials: N
authors.lastname: Mayseless
authors.affiliation: Department of Psychology, University of Haifa, Haifa, Israel.
authors.forename: Hagar
authors.initials: H
authors.lastname: Gelbard
authors.affiliation: Shalvata Mental Health Center, Hod Hasharon, Israel.
authors.forename: Yael Doreen
authors.initials: YD
authors.lastname: Lewis
authors.affiliation: Department of Psychiatry, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Barnea
authors.affiliation: Shalvata Mental Health Center, Hod Hasharon, Israel.
authors.forename: Kfir
authors.initials: K
authors.lastname: Feffer
authors.affiliation: Department of Psychology, University of Haifa, Haifa, Israel.
authors.forename: Simone G
authors.initials: SG
authors.lastname: Shamay-Tsoory
authors.affiliation: Shalvata Mental Health Center, Hod Hasharon, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Yuval
authors.initials: Y
authors.lastname: Bloch
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000188:drug therapy*; D001288:Attention / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D035061:Control Groups; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate
keywords: ADHD; Attention; Cognitive enhancer