title: Long Non-coding RNAs in the Cytoplasm.
abstract: An enormous amount of long non-coding RNAs (lncRNAs) transcribed from eukaryotic genome are important regulators in different aspects of cellular events. Cytoplasm is the residence and the site of action for many lncRNAs. The cytoplasmic lncRNAs play indispensable roles with multiple molecular mechanisms in animal and human cells. In this review, we mainly talk about functions and the underlying mechanisms of lncRNAs in the cytoplasm. We highlight relatively well-studied examples of cytoplasmic lncRNAs for their roles in modulating mRNA stability, regulating mRNA translation, serving as competing endogenous RNAs, functioning as precursors of microRNAs, and mediating protein modifications. We also elaborate the perspectives of cytoplasmic lncRNA studies.
authors.affiliation: CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
authors.forename: Farooq
authors.initials: F
authors.lastname: Rashid
authors.affiliation: CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Shah
authors.affiliation: CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. Electronic address: shange@ustc.edu.cn.
authors.forename: Ge
authors.initials: G
authors.lastname: Shan
mesh_terms: D000818:Animals; D003593:Cytoplasm / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D014176:Protein Biosynthesis / Q000235:genetics; D012322:RNA Precursors / Q000378:metabolism; D020871:RNA Stability; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D035683:MicroRNAs; D012322:RNA Precursors; D062085:RNA, Long Noncoding
keywords: MicroRNA; ceRNA; lncRNA; mRNA stability; mRNA translation