title: Equal sensitivity of the new generation QuantiFERON-TB Gold plus in direct comparison with the previous test version QuantiFERON-TB Gold IT.
abstract: QuantiFERON-TB Gold IT analyses interferon-γ release from CD4(+) T cells after stimulation with specific tuberculosis (TB) antigens. Its sensitivity is approximately 80% for active TB. A new test generation (QFTGplus) also analyses the response of CD8(+) T cells. We investigated both test generations in a direct head-to-head comparison in a German pulmonary hospital. Sensitivity rates for active TB were identical, no matter whether diagnosis was bacteriologically confirmed or not.
authors.affiliation: Synlab MVZ Gauting, Zweigniederlassung der synlab MVZ Augsburg GmbH, Gauting, Germany; IML red GmbH, Institute of Microbiology and Laboratory Medicine, WHO Supranational Reference Laboratory of Tuberculosis, Gauting, Germany. Electronic address: harald.hoffmann@synlab.com.
authors.forename: H
authors.initials: H
authors.lastname: Hoffmann
authors.affiliation: Asklepios Fachkliniken München Gauting, Infectious Disease Department, Gauting, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Avsar
authors.affiliation: Asklepios Fachkliniken München Gauting, Infectious Disease Department, Gauting, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Göres
authors.affiliation: Asklepios Fachkliniken München Gauting, Infectious Disease Department, Gauting, Germany.
authors.forename: S-C
authors.initials: SC
authors.lastname: Mavi
authors.affiliation: Synlab MVZ Gauting, Zweigniederlassung der synlab MVZ Augsburg GmbH, Gauting, Germany; IML red GmbH, Institute of Microbiology and Laboratory Medicine, WHO Supranational Reference Laboratory of Tuberculosis, Gauting, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Hofmann-Thiel
mesh_terms: D006801:Humans; D059425:Interferon-gamma Release Tests / Q000379:methods* / Q000592:standards; D055985:Latent Tuberculosis / Q000175:diagnosis; D009169:Mycobacterium tuberculosis; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D014376:Tuberculosis / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism / Q000382:microbiology
chemical_list: D011933:Reagent Kits, Diagnostic
keywords: Interferon-γ release assay; QuantiFERON-TB Gold in tube; QuantiFERON-TB Gold plus; Sensitivity; Tuberculosis