title: [Neurosarcoidosis - clinical characteristics, diagnosis and treatment].
abstract: Neurosarcoidosis (NS) manifests itself clinically in approximately 8-13% of patients with sarcoidosis. Granulomas are localized in both the central and peripheral nervous system, mainly within the meninges and cranial nerves. Changes may spread interstitially, occupying different structures of the brain and spinal cord. Diagnosis of NS is made by characteristic clinical symptoms and the exclusion of other diseases, with the presence of specific changes in the magnetic resonance and cerebrospinal fluid, and it is mainly based on histopathological examination. The first choice treatment are corticosteroids. In case of failure or adverse events, methotrexate, azathioprine, cyclosporine, cyclophosphamide, mycophenolate mofetil and infliximab could be used.
authors.affiliation: Katedra i Klinika Neurologii w Zabrzu Śląski Uniwersytet Medyczny, Katowice.
authors.forename: Maciej
authors.initials: M
authors.lastname: Horyniecki
authors.affiliation: Katedra i Klinika Neurologii w Zabrzu Śląski Uniwersytet Medyczny, Katowice.
authors.forename: Marta
authors.initials: M
authors.lastname: Konieczna
authors.affiliation: Katedra i Klinika Neurologii w Zabrzu Śląski Uniwersytet Medyczny, Katowice.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Torbus
authors.affiliation: Katedra i Klinika Neurologii w Zabrzu Śląski Uniwersytet Medyczny, Katowice.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Pierzchała
authors.affiliation: Katedra i Klinika Neurologii w Zabrzu Śląski Uniwersytet Medyczny, Katowice.
authors.forename: Maciej
authors.initials: M
authors.lastname: Wawrzyńczyk
authors.affiliation: Katedra i Klinika Neurologii w Zabrzu Śląski Uniwersytet Medyczny, Katowice.
authors.forename: Beata
authors.initials: B
authors.lastname: Łabuz-Roszak
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging*; D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D011859:Radiography; D012507:Sarcoidosis / Q000175:diagnosis* / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents