title: Arthroscopic bankart surgery: Does gabapentin reduce postoperative pain and opioid consumption? A triple-blinded randomized clinical trial.
abstract: The role of gabapentin as preemptive analgesia in managing acute pain following shoulder bankart arthroscopy is controversial and the studies addressing this issue are limited.
  
  
  
  The present study was undertaken to examine the effects of preemptive single dose of gabapentin on pain management and opioid consumption in patients undergoing arthroscopic bankart surgery.
  
  
  
  In the current triple-blinded randomized clinical trial, 76 eligible patients were randomly divided into two groups either taking gabapentin 600mg (G group) or placebo (P group). The primary outcomes were pain intensity assessed based on Visual Analogue Scale (VAS) and secondary outcomes were opioid consumption and side effects, dizziness, sedation, nausea and vomiting at 6h and 24h follow-up visits.
  
  
  
  The pain intensity were not significantly different between the G and P groups (P>0.05). The opioid consumption, however, was significantly reduced in G group at both 6h and 24h follow-up visits (P<0.001). Dizziness and sedation were similar in both groups. Nausea and vomiting were significantly lower in G group only at 6h visit but similar at 24h follow-up visit (P<0.001).
  
  
  
  The preemptive single dose of gabapentin 600mg administered prior to arthroscopic bankart surgery does not decrease post-operation pain, but reduces opioid consumption. Gabapentin restrained postoperative nausea and vomiting for a short while (less than 6h).
  
  
  
  Level I, treatment study.
authors.affiliation: Orthopedic Department, Guilan Road Trauma Center, Guilan University of Medical Sciences, Poursina Hospital, Rasht, Iran. Electronic address: Dr_Mohsen_mardani@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Mardani-Kivi
authors.affiliation: Orthopedic Department, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Karimi Mobarakeh
authors.affiliation: Orthopedic Surgery, Shahid Beheshti University of Medical Sciences, Akhtar Orthopedic Hospital, Tehran, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Keyhani
authors.affiliation: Anesthesiology Department, Guilan University Of Medical Sciences, Rasht, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Haghighi
authors.affiliation: Orthopedic Research Center, Guilan University of medical sciences, Rasht, Iran.
authors.forename: K
authors.initials: K
authors.lastname: Hashemi-Motlagh
authors.affiliation: Orthopedic Research Center, Guilan University of medical sciences, Rasht, Iran.
authors.forename: K
authors.initials: K
authors.lastname: Saheb-Ekhtiari
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000588:Amines / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D001182:Arthroscopy; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D000077206:Gabapentin; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control*; D011300:Preoperative Care / Q000379:methods*; D012785:Shoulder Joint / Q000601:surgery*; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
chemical_list: D000588:Amines; D000700:Analgesics; D000701:Analgesics, Opioid; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin
keywords: Analgesic side effects; Bankart surgery; Gabapentin; Preemptive analgesia; Randomized clinical trial