title: Rescue baroreflex activation therapy after Stanford B aortic dissection due to therapy-refractory hypertension.
abstract: Clinical trials have demonstrated significant and durable reduction in arterial pressure from baroreflex activation therapy (BAT) in patients with resistant arterial hypertension. There is a lack of data, however, concerning the use of BAT in a rescue approach during therapy-refractory hypertensive crisis resulting in life-threatening end-organ damage. Here, we describe the first case in which BAT was applied as a rescue procedure in an intensive care setting after ineffective maximum medical treatment. A 34-year-old male patient presented with Stanford B aortic dissection and hypertensive crisis. The dissection membrane extended from the left subclavian artery down to the right common iliac artery, resulting in a total arterial occlusion of the right leg. After emergency thoracic endovascular aortic repair and femorofemoral crossover bypass, the patient developed a compartment syndrome of the right lower limb, ultimately leading to amputation of the right leg above the knee. Even under deep sedation recurrent hypertensive crises of up to 220 mm Hg occurred that could not be controlled by eight antihypertensive drugs of different classes. Screening for secondary hypertension was negative. Eventually, rescue implantation of right-sided BAT was performed as a bailout procedure, followed by immediate activation of the device. After a hospital stay of a total of 8 weeks, the patient was discharged 2 weeks after BAT initiation with satisfactory blood pressure levels. After 1-year follow-up, the patient has not had a hypertensive crisis since the onset of BAT and is currently on fourfold oral antihypertensive therapy. The previously described bailout procedures for the treatment of life-threatening hypertensive conditions that are refractory to drug treatment have mainly comprised the interventional denervation of renal arteries. The utilization of BAT is new in this emergency context and showed a significant, immediate, and sustained reduction of blood pressure levels after activation. To our knowledge, we report the first case of an immediate activation of a barostim while the device is usually not activated before 2 to 4 weeks after implantation to allow time for the surgical site to heal. During the follow-up period, the healing process was not impaired, and a significant, immediate, and sustained reduction of blood pressure levels after activation could be observed. This treatment option offers maximum adherence to antihypertensive therapy to avoid future cardiovascular end-organ damage and possibly reduce antihypertensive medication and undesirable side effects.
authors.affiliation: Division of Cardiology, Department of Internal Medicine I, Justus-Liebig University of Giessen, Germany. Electronic address: kweipert@gmx.de.
authors.forename: Kay F
authors.initials: KF
authors.lastname: Weipert
authors.affiliation: Division of Cardiology, Department of Internal Medicine I, Justus-Liebig University of Giessen, Germany.
authors.forename: Astrid
authors.initials: A
authors.lastname: Most
authors.affiliation: Division of Cardiology, Department of Internal Medicine I, Justus-Liebig University of Giessen, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Dörr
authors.affiliation: Division of Cardiology, Department of Internal Medicine I, Justus-Liebig University of Giessen, Germany.
authors.forename: Inga
authors.initials: I
authors.lastname: Helmig
authors.affiliation: Department of Cardiovascular Surgery, Justus-Liebig University of Giessen, Germany.
authors.forename: Meshal
authors.initials: M
authors.lastname: Elzien
authors.affiliation: Department of Radiology, Justus-Liebig University of Giessen, Germany.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Krombach
authors.affiliation: Division of Cardiology, Department of Internal Medicine I, Justus-Liebig University of Giessen, Germany.
authors.forename: Christian W
authors.initials: CW
authors.lastname: Hamm
authors.affiliation: Division of Cardiology, Department of Internal Medicine I, Justus-Liebig University of Giessen, Germany.
authors.forename: Damir
authors.initials: D
authors.lastname: Erkapic
authors.affiliation: Division of Cardiology, Department of Internal Medicine I, Justus-Liebig University of Giessen, Germany.
authors.forename: Joern
authors.initials: J
authors.lastname: Schmitt
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000601:surgery; D017704:Baroreflex; D001794:Blood Pressure; D001795:Blood Pressure Determination; D002346:Carotid Sinus / Q000502:physiology; D000072226:Computed Tomography Angiography; D003329:Coronary Vasospasm / Q000150:complications / Q000628:therapy*; D003422:Critical Care / Q000379:methods*; D004599:Electric Stimulation Therapy / Q000295:instrumentation / Q000379:methods*; D057510:Endovascular Procedures; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000628:therapy*; D008297:Male
chemical_list: D000959:Antihypertensive Agents
keywords: Aortic dissection; bailout procedure; baroreflex activation therapy; therapy-refractory arterial hypertension