title: Heterogeneous vascular patterns in renal cell carcinomas.
abstract: The present study proposes a classification of renal cancer tumor blood vessels according to their morphology and maturation grade. We identified four vascular patterns: reticular, diffuse, fasciculated and trabecular. The reticular pattern was present in 63% of cases, being characterized by the predominance of mature CD34+/SMAct+ tumor vessels, highly interconnected. For this pattern, 74% of cases had vascular invasion, and a significant correlation was observed between tumor grade and immature state of tumor vessels (p = 0.022). The diffuse pattern was observed in 23% of cases and was characterized by non-interconnected vessels predominantly of mature CD34+/SMAct+ type and vascular invasion in 64% of cases. Only 8% of cases, had a fasciculate model of vessels distribution, all of them being of mature type, located in the connective axis of papillary renal tumors. For this pattern vascular invasion was found in 50% of cases. In 6% of cases a trabecular pattern was observed and the lowest rate of vascular invasion was registered. We defined here four distinct vascular patterns in renal cell carcinomas showing a strong impact on vascular invasion. A complete morphological and molecular characterization of tumor vessels would be beneficial in elucidating the mechanisms that underlie the ineffectiveness of antiangiogenic/antitumor therapies.
authors.forename: O
authors.initials: O
authors.lastname: Ferician
authors.affiliation: Anca Maria Cimpean MD, PhD, Professor of Histology, Department of Microscopic Morphology/Histology, Angiogenesis Research Center Timisoara, Pta Eftimie Murgu 2, 300041 Timisoara, Romania, e-mail: ancacimpean1972@yahoo.com.
authors.forename: A M
authors.initials: AM
authors.lastname: Cimpean
authors.forename: A R
authors.initials: AR
authors.lastname: Ceausu
authors.forename: A
authors.initials: A
authors.lastname: Dema
authors.forename: M
authors.initials: M
authors.lastname: Raica
authors.forename: A
authors.initials: A
authors.lastname: Cumpanas
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000098:blood supply* / Q000145:classification / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000098:blood supply* / Q000145:classification / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor