title: Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells.
abstract: Three new γ-ionylideneacetic acid derivatives, phellinulins A-C (1-3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.
authors.affiliation: Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan. schuang@mail.cnu.edu.tw.
authors.forename: Shiow-Chyn
authors.initials: SC
authors.lastname: Huang
authors.affiliation: School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. z10502016@email.ncku.edu.tw.
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.affiliation: School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. z10308005@email.ncku.edu.tw.
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Hung
authors.affiliation: School of Traditional Chinese Medicine, Chang Gung University, Taoyuan 333, Taiwan. pan@mail.cgu.edu.tw.|Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. pan@mail.cgu.edu.tw.|Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. pan@mail.cgu.edu.tw.
authors.forename: Tai-Long
authors.initials: TL
authors.lastname: Pan
authors.affiliation: Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan. fachen@tajen.edu.tw.
authors.forename: Fu-An
authors.initials: FA
authors.lastname: Chen
authors.affiliation: School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. tswu@mail.ncku.edu.tw.|Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan. tswu@mail.ncku.edu.tw.
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000040:Abscisic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D000818:Animals; D001487:Basidiomycota / Q000737:chemistry; D056945:Hep G2 Cells; D055166:Hepatic Stellate Cells / Q000187:drug effects*; D006801:Humans; D045792:Norisoprenoids / Q000737:chemistry / Q000494:pharmacology; D000084682:Phellinus; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats
chemical_list: D045792:Norisoprenoids; C526145:Phellinus linteus extract; D010936:Plant Extracts; C425561:gamma-ionylideneacetic acid; D000040:Abscisic Acid
keywords: Phellinus linteus; fungus; hepatic fibrosis; ionone; phellinulin