title: In Vitro Cell Models for Ophthalmic Drug Development Applications.
abstract: Tissue engineering is a rapidly expanding field that aims to establish feasible techniques to fabricate biologically equivalent replacements for diseased and damaged tissues/organs. Emerging from this prospect is the development of in vitro representations of organs for drug toxicity assessment. Due to the ever-increasing interest in ocular drug delivery as a route for administration as well as the rise of new ophthalmic therapeutics, there is a demand for physiologically accurate in vitro models of the eye to assess drug delivery and safety of new ocular medicines. This review summarizes current existing ocular models and highlights the important factors and limitations that need to be considered during their use.
authors.affiliation: Department of Pharmacy, Pharmacology, and Postgraduate Medicine, The Research Center in Topical Drug Delivery and Toxicology, School of Life and Medical Sciences, University of Hertfordshire , Hertfordshire, United Kingdom .
authors.forename: Sara
authors.initials: S
authors.lastname: Shafaie
authors.affiliation: Department of Pharmacy, Pharmacology, and Postgraduate Medicine, The Research Center in Topical Drug Delivery and Toxicology, School of Life and Medical Sciences, University of Hertfordshire , Hertfordshire, United Kingdom .
authors.forename: Victoria
authors.initials: V
authors.lastname: Hutter
authors.affiliation: Department of Pharmacy, Pharmacology, and Postgraduate Medicine, The Research Center in Topical Drug Delivery and Toxicology, School of Life and Medical Sciences, University of Hertfordshire , Hertfordshire, United Kingdom .
authors.forename: Michael T
authors.initials: MT
authors.lastname: Cook
authors.affiliation: Department of Pharmacy, Pharmacology, and Postgraduate Medicine, The Research Center in Topical Drug Delivery and Toxicology, School of Life and Medical Sciences, University of Hertfordshire, Hertfordshire, United Kingdom.; MedPharm Ltd., Guildford, Surrey, United Kingdom.
authors.forename: Marc B
authors.initials: MB
authors.lastname: Brown
authors.affiliation: Department of Pharmacy, Pharmacology, and Postgraduate Medicine, The Research Center in Topical Drug Delivery and Toxicology, School of Life and Medical Sciences, University of Hertfordshire , Hertfordshire, United Kingdom .
authors.forename: David Y S
authors.initials: DY
authors.lastname: Chau
keywords: cell culture; drug delivery; ophthalmology; tissue engineering; toxicity testing