title: Do the Anti-Müllerian Hormone Levels of Adolescents with Polycystic Ovary Syndrome, Those Who Are at Risk for Developing Polycystic Ovary Syndrome, and Those Who Exhibit Isolated Oligomenorrhea Differ from Those of Adolescents with Normal Menstrual Cycles?
abstract: OBJECTIVE
  We aimed to investigate whether the anti-Müllerian hormone (AMH) levels in adolescents with polycystic ovary syndrome (PCOS), PCOS risk, and isolated oligomenorrhea (OM) were different than in adolescents with a normal/regular menstrual cycle (NMC).
  
  
  METHODS
  The diagnosis of PCOS was based on the 2012 Amsterdam [European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine (ESHRE/ASRM)] criteria. The PCOS group consisted of cases meeting 3 diagnostic criteria (n = 21), and the PCOS risk group was the 'at risk' group meeting 2 diagnostic criteria (n = 20). Cases with isolated OM that did not satisfy other PCOS diagnostic criteria made up the OM group (n = 21). Thirty adolescent girls with NMCs (21-45 days) were recruited in this study.
  
  
  RESULTS
  The AMH levels in the PCOS group were similar to those in the PCOS risk group but significantly higher than those in the OM and NMC groups. The AMH levels in the PCOS risk group were similar to those in the OM group and significantly higher than those in the NMC group. They were also significantly higher in the OM group compared to the NMC group. The specificity for PCOS and PCOS risk with a cutoff value of 7.25 ng/ml for AMH was 72.5% and the sensitivity was 58%.
  
  
  CONCLUSIONS
  An AMH cutoff value of 7.25 ng/ml can be used for the diagnosis of PCOS in the adolescent period.
authors.affiliation: Department of Pediatric Endocrinology, Dr. Sami Ulus Obstetrics and Gynecology, Children's Health and Disease Training and Research Hospital, Ankara, Turkey.
authors.forename: Senay
authors.initials: S
authors.lastname: Savas-Erdeve
authors.forename: Meliksah
authors.initials: M
authors.lastname: Keskin
authors.forename: Elif
authors.initials: E
authors.lastname: Sagsak
authors.forename: Funda
authors.initials: F
authors.lastname: Cenesiz
authors.forename: Semra
authors.initials: S
authors.lastname: Cetinkaya
authors.forename: Zehra
authors.initials: Z
authors.lastname: Aycan
mesh_terms: D000293:Adolescent; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood*; D009839:Oligomenorrhea / Q000097:blood / Q000175:diagnosis; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis; D011237:Predictive Value of Tests
chemical_list: D054304:Anti-Mullerian Hormone