title: Validation of a New Noninvasive Intracranial Pressure Monitoring Method by Direct Comparison with an Invasive Technique.
abstract: The search for a completely noninvasive intracranial pressure (ICPni) monitoring technique capable of real-time digitalized monitoring is the Holy Grail of brain research. If available, it may facilitate many fundamental questions within the range of ample applications in neurosurgery, neurosciences and translational medicine, from pharmaceutical clinical trials, exercise physiology, and space applications. In this work we compare invasive measurements with noninvasive measurements obtained using the proposed new noninvasive method. Saline was infused into the spinal channel of seven rats to produce ICP changes and the simultaneous acquisition of both methods was performed. The similarity in the invasive and noninvasive methods of ICP monitoring was calculated using Pearson's correlation coefficients (r). Good agreement between measures < r > = 0.8 ± 0.2 with a range 0.28-0.96 was shown.
authors.affiliation: SAPRA Assessoria, São Carlos, Brazil.|University of São Paulo, São Paulo, Brazil.
authors.forename: Brenno
authors.initials: B
authors.lastname: Cabella
authors.affiliation: SAPRA Assessoria, São Carlos, Brazil.|University of São Paulo, São Paulo, Brazil.
authors.forename: Gustavo Henrique Frigieri
authors.initials: GH
authors.lastname: Vilela
authors.affiliation: University of São Paulo, São Paulo, Brazil. sergiomascarenhas28@gmail.com.
authors.forename: Sérgio
authors.initials: S
authors.lastname: Mascarenhas
authors.affiliation: Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
authors.forename: Marek
authors.initials: M
authors.lastname: Czosnyka
authors.affiliation: Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Smielewski
authors.affiliation: University of Porto, Porto, Portugal.
authors.forename: Celeste
authors.initials: C
authors.lastname: Dias
authors.affiliation: Federal University of São Carlos, São Carlos, Brazil.
authors.forename: Danilo Augusto
authors.initials: DA
authors.lastname: Cardim
authors.affiliation: University of São Paulo, São Paulo, Brazil.
authors.forename: Charles Chenwei
authors.initials: CC
authors.lastname: Wang
authors.affiliation: University of São Paulo, São Paulo, Brazil.
authors.forename: Paulo
authors.initials: P
authors.lastname: Mascarenhas
authors.affiliation: University of São Paulo, São Paulo, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Andrade
authors.affiliation: University of São Paulo, São Paulo, Brazil.
authors.forename: Koji
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: University of São Paulo, São Paulo, Brazil.
authors.forename: Luiza
authors.initials: L
authors.lastname: Silva Lopes
authors.affiliation: University of São Paulo, São Paulo, Brazil.
authors.forename: Benedicto Oscar
authors.initials: BO
authors.lastname: Colli
mesh_terms: D000818:Animals; D004867:Equipment Design; D019586:Intracranial Hypertension / Q000175:diagnosis / Q000503:physiopathology*; D007427:Intracranial Pressure / Q000502:physiology*; D008991:Monitoring, Physiologic; D051381:Rats; D012886:Skull / Q000502:physiology / Q000503:physiopathology*
keywords: ICP; Intracranial pressure; Medical instrumentation; Monitor; Noninvasive system