title: Osteoclastic-Type Giant Cell Tumours of the Pancreas: A Homogenous Series of Rare Tumours Diagnosed by Endoscopic Ultrasound.
abstract: BACKGROUND
  Giant cell tumors (GCT) of the pancreas are a rare form of pancreatic cancer. Although data are limited, clinical outcomes appear to depend largely on histological subtype with osteoclastic tumors carrying a better prognosis. We report on a homogenous series of patients with osteoclastic-type GCTs of the pancreas presenting to a national pancreatico-biliary gastrointestinal oncology center.
  
  
  METHODS
  Patients underwent endoscopic, radiological and histopathological assessments. Data were collected in relation to consecutive patients presenting with osteoclastic-type tumors of the pancreas and analyzed with survival as a primary end point.
  
  
  RESULTS
  Four patients were treated over a 4-year period. Median age was 77 years with equal gender distribution. Median tumor size was 42 mm. Histology was osteoclast-type giant cells in all 4 patients. Two patients underwent surgery with curative intent. Median overall survival was 13.1 months.
  
  
  CONCLUSIONS
  This is the largest reported series of osteoclast-type histology in GCTs of the pancreas.
authors.affiliation: Department of Gastroenterology, St. James's Hospital, Dublin, Ireland.
authors.forename: Conor
authors.initials: C
authors.lastname: Lahiff
authors.forename: Niall
authors.initials: N
authors.lastname: Swan
authors.forename: Kevin
authors.initials: K
authors.lastname: Conlon
authors.forename: Dermot
authors.initials: D
authors.lastname: Malone
authors.forename: Donal
authors.initials: D
authors.lastname: Maguire
authors.forename: Emir
authors.initials: E
authors.lastname: Hoti
authors.forename: Justin
authors.initials: J
authors.lastname: Geoghegan
authors.forename: Gerry
authors.initials: G
authors.lastname: McEntee
authors.forename: Dermot
authors.initials: D
authors.lastname: O'Toole
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019160:Endosonography; D005260:Female; D005870:Giant Cell Tumors / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010010:Osteoclasts; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden