title: Congenital self-healing reticulohistiocytosis: an underreported entity.
abstract: Langerhans cell histiocytosis (LCH), also known as histiocytosis X, is a group of rare disorders characterized by the continuous replication of a particular white blood cell called Langerhans cells. These cells are derived from the bone marrow and are found in the epidermis, playing a large role in immune surveillance and the elimination of foreign substances from the body. Additionally, Langerhans cells are capable of migrating from the skin to lymph nodes, and in LCH, these cells begin to congregate on the bone, particularly in the head and neck region, causing a multitude of problems. Langerhans cell histiocytosis is classified into 4 variants: congenital self-healing reticulohistiocytosis (CSHR)(also known as Hashimoto-Pritzker disease), Letterer-Siwe disease, Hand-Schüller-Christian disease, and eosinophilic granuloma. Despite various clinical presentations and severity, all subtypes are pathologically caused by the proliferation of the Langerhans cell.
authors.affiliation: Western University of Health Sciences, Pomona, California, and the Department of Dermatology, Pacific Hospital of Long Beach, California, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Kassardjian
authors.affiliation: Western University of Health Sciences, Pomona, California, and the Department of Dermatology, Pacific Hospital of Long Beach, California, USA.
authors.forename: Mayha
authors.initials: M
authors.lastname: Patel
authors.affiliation: Department of Dermatology, Harbor-UCLA Medical Center, Torrance, California, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Shitabata
authors.affiliation: Western University of Health Sciences, Pomona, California, and the Department of Dermatology, Pacific Hospital of Long Beach, California, USA.
authors.forename: David
authors.initials: D
authors.lastname: Horowitz
mesh_terms: D003937:Diagnosis, Differential; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D012075:Remission, Spontaneous