title: Increased Lipocalin 2 level may have important role in thrombotic events in patients with polycythemia vera and essential thrombocythemia.
abstract: The aim of our study was to evaluate the possible effect of lipocalin 2 on thrombotic events in polycythemia vera and essential thrombocythemia patients. The samples of 89 patients were collected and RNA based method was used to evaluate the relative gene expression level of lipocalin 2. 74 samples were available for evaluation. Drawing a cut off point at level 30 relative expression rate, 13 patients with elevated lipocalin 2 expression had thrombotic events during the course of their disease. Based on these data high lipocalin 2 expression level seems to have strong positive predictive value on thrombotic events in patients with polycythemia vera and essential thrombocythemia. Lipocalin 2 may be useful in thrombotic risk stratification in these patients.
authors.affiliation: Kaposi Mor Teaching Hospital, Department of Hematology, Kaposvár, Hungary. Electronic address: rajnicsp@hotmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Rajnics
authors.affiliation: Kaposi Mor Teaching Hospital, Department of Hematology, Kaposvár, Hungary.
authors.forename: Á
authors.initials: Á
authors.lastname: Kellner
authors.affiliation: Kaposi Mor Teaching Hospital, Department of Hematology, Kaposvár, Hungary.
authors.forename: É
authors.initials: É
authors.lastname: Karádi
authors.affiliation: Kaposi Mor Teaching Hospital, Department of Hematology, Kaposvár, Hungary.
authors.forename: M
authors.initials: M
authors.lastname: Moizs
authors.affiliation: MTA-SE Lendulet Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University.
authors.forename: Cs
authors.initials: C
authors.lastname: Bödör
authors.affiliation: MTA-SE Lendulet Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University.
authors.forename: P A
authors.initials: PA
authors.lastname: Király
authors.affiliation: MTA-SE Lendulet Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University.
authors.forename: D
authors.initials: D
authors.lastname: Marosvári
authors.affiliation: Hungarian National Blood Transfusion Service, Laboratory of Molecular Diagnostics, Budapest, Hungary.
authors.forename: H
authors.initials: H
authors.lastname: Andrikovics
authors.affiliation: Kaposi Mor Teaching Hospital, Department of Hematology, Kaposvár, Hungary.
authors.forename: M
authors.initials: M
authors.lastname: Egyed
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015870:Gene Expression; D006801:Humans; D000071068:Lipocalin-2 / Q000032:analysis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000150:complications / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012333:RNA, Messenger / Q000032:analysis; D018570:Risk Assessment; D013920:Thrombocythemia, Essential / Q000150:complications / Q000175:diagnosis*; D013927:Thrombosis / Q000175:diagnosis* / Q000209:etiology; D055815:Young Adult
chemical_list: D000071068:Lipocalin-2; D012333:RNA, Messenger
keywords: Essential thrombocythemia; Lipocalin 2; Polycythemia vera; Thrombosis