title: A Wounded Nucleus Needs ESCRT Service.
abstract: Two recent publications in Science report on frequent rupturing events of the nuclear envelope induced by migration of cells through narrow openings. Nuclear envelope "wounds" are repaired by the ESCRT-III machinery to limit DNA damage, nuclear fragmentation, and cell death.
authors.affiliation: Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland.
authors.forename: Rosemarie
authors.initials: R
authors.lastname: Ungricht
authors.affiliation: Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland. Electronic address: ulrike.kutay@bc.biol.ethz.ch.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Kutay
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009685:Nuclear Envelope / Q000378:metabolism
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport