title: Subclinical hypothyroidism is associated with metabolic syndrome and clomiphene citrate resistance in women with polycystic ovary syndrome.
abstract: BACKGROUND
  To evaluate the possible relationship between subclinical hypothyroidism (SCH) and metabolic syndrome (MS) and the response to clomiphene citrate (CC) stimulation in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  One hundred and ninety-six women with PCOS were divided into two groups: (1) the SCH group with 92 patients; (2) the euthyroid (EU) group with 104 patients. Physical characteristics and metabolic parameters as well as the reaction to CC stimulating test were compared between these two groups.
  
  
  RESULTS
  (1) In the SCH group, significantly higher body mass index, Ferriman-Gallwey score, serum triglyceride, insulin and glucose of oral glucose tolerance test, homeostatic model assessment-insulin resistance (HOMA-IR) and significantly lower serum high-density lipoprotein cholesterol was observed in comparison with those in the EU group (p < 0.05). (2) The prevalence of CC resistance (30.4%), IR (43.5%) and MS (34.8%) in the SCH group was significantly higher than that in the EU group (p < 0.05).
  
  
  CONCLUSIONS
  SCH was found associated with IR, MS and CC resistance in women with PCOS. PCOS patients with SCH may have a poorer treatment response to ovulation induction with CC.
authors.affiliation: a Center for Reproductive Medicine, Shaoxing Women and Children's Hospital , Shaoxing , China.
authors.forename: Yue-Hong
authors.initials: YH
authors.lastname: Lu
authors.affiliation: a Center for Reproductive Medicine, Shaoxing Women and Children's Hospital , Shaoxing , China.
authors.forename: Zhou-Lan
authors.initials: ZL
authors.lastname: Xia
authors.affiliation: a Center for Reproductive Medicine, Shaoxing Women and Children's Hospital , Shaoxing , China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Ma
authors.affiliation: a Center for Reproductive Medicine, Shaoxing Women and Children's Hospital , Shaoxing , China.
authors.forename: Hui-Juan
authors.initials: HJ
authors.lastname: Chen
authors.affiliation: a Center for Reproductive Medicine, Shaoxing Women and Children's Hospital , Shaoxing , China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Yan
authors.affiliation: a Center for Reproductive Medicine, Shaoxing Women and Children's Hospital , Shaoxing , China.
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Xu
mesh_terms: D000328:Adult; D002996:Clomiphene; D004351:Drug Resistance / Q000502:physiology*; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology; D024821:Metabolic Syndrome / Q000097:blood*; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D055815:Young Adult
chemical_list: D004965:Estrogen Antagonists; D002996:Clomiphene
keywords: CC resistance; IR; MS; PCOS; SCH