title: UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin.
abstract: Ultraviolet (UV) exposure to the human skin reduces triglycerides contents and lipid synthesis in the subcutaneous (SC) fat. Because adiponectin and leptin are the most abundant adipokines from the SC fat, we aim to investigate how they interact with UV exposure and skin aging. The expressions of adiponectin and leptin were significantly decreased in SC fat of sun-exposed forearm skin, in comparison with that of sun-protected buttock skin of the same elderly individuals, indicating that chronic UV exposure decreases both adipokines. Acute UV irradiation also decreased the expressions of adiponectin and leptin in SC fat. The expressions of adiponectin receptor 1/2 and leptin receptor were significantly decreased in the dermis as well as in SC fat. Moreover, while exogenous adiponectin and leptin administration prevented UV- and TNF-α induced matrix metalloproteinase (MMP)-1 expression, they also increased UV- and TNF-α induced reduction of type 1 procollagen production. Silencing of adiponectin, leptin or their receptors led to an increased MMP-1 and a decreased type 1 procollagen expression, which was reversed by treatment with recombinant human adiponectin or leptin. In conclusion, UV exposure decreases the expression of adiponectin and leptin, leading to the exacerbation of photoaging by stimulating MMP-1 expression and inhibiting procollagen synthesis.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.|Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.|Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Republic of Korea.
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.|Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.|Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Republic of Korea.
authors.forename: Yeon Kyung
authors.initials: YK
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.|Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.|Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Republic of Korea.
authors.forename: Min-Kyoung
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.|Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.|Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Republic of Korea.
authors.forename: Sungsoo
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.|Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.|Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Republic of Korea.
authors.forename: Jin Yong
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.|Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.|Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Republic of Korea.
authors.forename: Dong Hun
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.|Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.|Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Republic of Korea.|Institute on Aging, Seoul National University, Seoul, Republic of Korea.
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Chung
mesh_terms: D054392:Adipokines / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D020405:Dermis / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D015870:Gene Expression / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000235:genetics / Q000378:metabolism*; D059748:Proteolysis / Q000187:drug effects / Q000528:radiation effects; D034622:RNA Interference; D054419:Receptors, Adiponectin / Q000235:genetics / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D015595:Skin Aging / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects; D050151:Subcutaneous Fat / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D054392:Adipokines; D054419:Receptors, Adiponectin; D020781:Matrix Metalloproteinase 1