title: Biologic Treatments for Sports Injuries II Think Tank-Current Concepts, Future Research, and Barriers to Advancement, Part 1: Biologics Overview, Ligament Injury, Tendinopathy.
abstract: Biologic therapies, including stem cells, platelet-rich plasma, growth factors, and other biologically active adjuncts, have recently received increased attention in the basic science and clinical literature. At the 2015 AOSSM Biologics II Think Tank held in Colorado Springs, Colorado, a group of orthopaedic surgeons, basic scientists, veterinarians, and other investigators gathered to review the state of the science for biologics and barriers to implementation of biologics for the treatment of sports medicine injuries. This series of current concepts reviews reports the summary of the scientific presentations, roundtable discussions, and recommendations from this think tank.
authors.affiliation: Steadman Philippon Research Institute, Vail, Colorado, USA drlaprade@sprivail.org.
authors.forename: Robert F
authors.initials: RF
authors.lastname: LaPrade
authors.affiliation: Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan, USA.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Geeslin
authors.affiliation: University of Edinburgh, Edinburgh, UK.
authors.forename: Iain R
authors.initials: IR
authors.lastname: Murray
authors.affiliation: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
authors.forename: Volker
authors.initials: V
authors.lastname: Musahl
authors.affiliation: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
authors.forename: Jason P
authors.initials: JP
authors.lastname: Zlotnicki
authors.affiliation: University of California, Los Angeles, California, USA.
authors.forename: Frank
authors.initials: F
authors.lastname: Petrigliano
authors.affiliation: Author deceased.|American Orthopaedic Society for Sports Medicine, Rosemont, Illinois, USA.
authors.forename: Barton J
authors.initials: BJ
authors.lastname: Mann
mesh_terms: D001265:Athletic Injuries / Q000628:therapy*; D001688:Biological Products / Q000627:therapeutic use*; D035843:Biomedical Research / Q000639:trends; D016207:Cytokines / Q000627:therapeutic use; D005544:Forecasting; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use; D008022:Ligaments / Q000293:injuries*; D053657:Platelet-Rich Plasma; D013178:Sports Medicine; D033581:Stem Cell Transplantation; D052256:Tendinopathy / Q000628:therapy*; D013708:Tendon Injuries / Q000628:therapy
chemical_list: D001688:Biological Products; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins
keywords: cartilage; growth factors; ligament injury; mesenchymal stem cells; platelet-rich plasma; rotator cuff; tendinopathy