title: [Relationship between human immunodeficiency virus (HIV-AIDS) and conjunctival squamous cell carcinoma: A clinical epidemiological study of 26 cases in the ophthalmology department of the university hospital of Treichville-Abidjan (Abidjan-Côte d'Ivoire)].
abstract: OBJECTIVE
  To describe the epidemiological and clinical parameters of conjunctival squamous cell carcinomas and their association with HIV-AIDS in the ophthalmology department of the university hospital of Treichville.
  
  
  METHODS
  This is a prospective and descriptive cross sectional study carried out in the ophthalmology department of the university hospital of Treichville from July 2007 to June 2011. Twenty-six (26) patients who were selected presented with a tumor of the globe and/or adnexa. A CT scan was performed in advanced cases. Histopathological examination of the surgical specimen was performed in all cases. HIV serology was performed after informed consent. All patients were referred to the oncology department of the university hospital of Treichville where a unit of care for HIV-positive patients with malignant tumors is available. Statistical analysis was performed using the software program EPI info version 6.0.
  
  
  RESULTS
  We note a slight predominance of female patients 15 (57.69%) vs. 11 (42.3%) male patients. The mean age was 42.32 years, and 13 patients (50%) were between 25 and 45 years of age. Intraorbital tumors were the most common reason for consultation, i.e. 38.46%. Seventeen patients (65.38%) had no particular history. Nine patients (34.61%) were already on antiretroviral treatment on admission. Three patients, i.e. 11.54%, had already had tumor biopsy and/or evisceration. The mean duration of the disease before consultation in ophthalmology was 14.28 months. Localized limbal conjunctival tumors were found in 11 cases (42.38%). Advanced tumors with regional or cerebral extension accounted for 34.61% of cases. Six patients (23.078%) were HIV negative vs. 20 (76.92%) HIV positive patients. CD4 lymphocyte typing was performed in 17 patients (85%), and 45% had a CD4 count below 200. Only five patients were able to receive neoadjuvant chemotherapy, but three of them died. The average length of follow-up was 29 months.
  
  
  CONCLUSIONS
  This study allowed us to establish a statistically significant link between HIV positive status of patients and the occurrence of squamous cell carcinoma, (P=10(-4)), as well as the decline in CD4 count and disease progression (p=10(-3)).
  
  
  CONCLUSIONS
  The poor prognosis of conjunctival carcinoma reflects the low socioeconomic status of patients, physician under-staffing in our health care facilities, the prohibitive cost of anticancer drugs and the link between this disease and HIV-AIDS.
authors.affiliation: Service d'ophtalmologie, CHU de Treichville, BP V3, Abidjan, Cote d'Ivoire. Electronic address: berete1rokia7@gmail.com.
authors.forename: C R
authors.initials: CR
authors.lastname: Berete
authors.affiliation: Service d'ophtalmologie, institut curie, rue d'Ulm, 75005 Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Desjardins
authors.affiliation: Service d'ophtalmologie, CHU de Treichville, BP V3, Abidjan, Cote d'Ivoire.
authors.forename: L J
authors.initials: LJ
authors.lastname: Kouassi
authors.affiliation: Service d'ophtalmologie, CHU de Treichville, BP V3, Abidjan, Cote d'Ivoire.
authors.forename: F
authors.initials: F
authors.lastname: Coulibaly
authors.affiliation: Service d'ophtalmologie, CHU de Treichville, BP V3, Abidjan, Cote d'Ivoire.
authors.forename: K S
authors.initials: KS
authors.lastname: Kouakou
authors.affiliation: Service d'ophtalmologie, CHU de Treichville, BP V3, Abidjan, Cote d'Ivoire.
authors.forename: K
authors.initials: K
authors.lastname: Gbe
authors.affiliation: Service d'ophtalmologie, CHU de Treichville, BP V3, Abidjan, Cote d'Ivoire.
authors.forename: A
authors.initials: A
authors.lastname: Fanny
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000453:epidemiology*; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000453:epidemiology*; D003230:Conjunctival Neoplasms / Q000150:complications / Q000453:epidemiology*; D007560:Cote d'Ivoire / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D015497:HIV-1; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: Carcinome épidermoïde; Conjonctive; Conjunctiva; Human immunodeficiency virus; Les rayons ultraviolets; Squamous cell carcinoma; Ultraviolet rays; Virus de l’immunodéficience acquise