title: The staging value of sentinel lymph node biopsy for breast cancer: translating pathologic findings to clinical practice.
abstract: Axillary nodal status is an important prognostic factor in guiding locoregional and systemic treatment for breast cancer. Sentinel lymph node biopsy (SNB) has revolutionized axillary staging by replacing axillary lymph node dissection (ALND) in node-negative women. Even in select patients whose sentinel lymph nodes (SLNs) contain metastases, SNB alone has become an accepted method of managing the axilla. Identification of micrometastases through immunohistochemical analysis of SLNs that are tumorfree on hematoxylin and eosin staining (H&E) does not confer additional clinical benefit. The use of SNB after neoadjuvant chemotherapy (NAC) remains controversial. In addition to axillary nodal status, tumor biology plays an increasingly important role in guiding therapeutic decisions.
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors.forename: Jean
authors.initials: J
authors.lastname: Bao
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors.forename: Cory
authors.initials: C
authors.lastname: Donovan
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors.forename: Alice
authors.initials: A
authors.lastname: Chung
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, CA, USA. Email: Armando.Giuliano@cshs.org.
authors.forename: Armando E
authors.initials: AE
authors.lastname: Giuliano
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D009367:Neoplasm Staging; D016032:Randomized Controlled Trials as Topic; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*
keywords: Sentinel node; axillary staging; histopathologic analysis