title: Surface patterned pH-sensitive fluorescence using β-cyclodextrin functionalized poly(ethylene glycol).
abstract: This paper reports the development of a pH-responsive molecular pattern that shows specific and selective affinity for particular host-guest interactions, and its use as a pH fluorescent sensor. The pH-responsive boronate ester is formed via interactions between the diol group of β-cyclodextrin (CD) and phenylboronic acid of poly(ethylene glycol), and is strategically designed to allow reversible formation of a molecular lining pattern. Printing on a versatile substrate provides a method to monitor the positioning of different molecules by using a pH-responsive boronate ester, allowing specific host-guest interactions on any surface. Confocal laser scanning microscopy, fluorescence spectroscopy, and (1)H NMR results indicate that the assembled CD monolayer can be removed by washing with an acidic pH buffer, demonstrating the presence of a boronate ester connective bridge, which is acid labile. Therefore, visualization of the pH-responsive fluorescence sensor using a rhodamine-CD complex allows straightforward discrimination between different molecules on any substrate, thus facilitating application of this sensor in clinical diagnostics and environmental monitoring.
authors.affiliation: Department of IT Convergence, Korea National University of Transportation, Chungju 380-702, Republic of Korea.
authors.forename: Sung Han
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-702, Republic of Korea.
authors.forename: Shazid Md
authors.initials: SM
authors.lastname: Sharker
authors.affiliation: Department of IT Convergence, Korea National University of Transportation, Chungju 380-702, Republic of Korea; Department of Polymer Science and Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea.
authors.forename: Insik
authors.initials: I
authors.lastname: In
authors.affiliation: Department of IT Convergence, Korea National University of Transportation, Chungju 380-702, Republic of Korea; Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea. Electronic address: parkchem@ut.ac.kr.
authors.forename: Sung Young
authors.initials: SY
authors.lastname: Park
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000295:instrumentation / Q000379:methods*; D004784:Environmental Monitoring / Q000379:methods*; D004952:Esters / Q000737:chemistry; D005453:Fluorescence; D006863:Hydrogen-Ion Concentration; D011092:Polyethylene Glycols / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D004952:Esters; D047392:beta-Cyclodextrins; D011092:Polyethylene Glycols
keywords: Boronate ester; Cyclodextrin; Host-guest interaction; Surface pattern; pH responsive