title: Extracting functional trends from whole genome duplication events using comparative genomics.
abstract: BACKGROUND
  The number of species with completed genomes, including those with evidence for recent whole genome duplication events has exploded. The recently sequenced Atlantic salmon genome has been through two rounds of whole genome duplication since the divergence of teleost fish from the lineage that led to amniotes. This quadrupoling of the number of potential genes has led to complex patterns of retention and loss among gene families.
  
  
  RESULTS
  Methods have been developed to characterize the interplay of duplicate gene retention processes across both whole genome duplication events and additional smaller scale duplication events. Further, gene expression divergence data has become available as well for Atlantic salmon and the closely related, pre-whole genome duplication pike and methods to describe expression divergence are also presented. These methods for the characterization of duplicate gene retention and gene expression divergence that have been applied to salmon are described.
  
  
  CONCLUSIONS
  With the growth in available genomic and functional data, the opportunities to extract functional inference from large scale duplicates using comparative methods have expanded dramatically. Recently developed methods that further this inference for duplicated genes have been described.
authors.affiliation: Department of Molecular Biology, University of Wyoming, Laramie, WY 82071 USA ; Center for Computational Genetics and Genomics and Department of Biology, Temple University, Philadelphia, PA 19122 USA.
authors.forename: Russell A
authors.initials: RA
authors.lastname: Hermansen
authors.affiliation: Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, 1432 Ås, Norway ; Department of Plant Physiology, Umeå Plant Science Centre, Umeå University, 90187 Umeå, Sweden.
authors.forename: Torgeir R
authors.initials: TR
authors.lastname: Hvidsten
authors.affiliation: Department of Animal and Aquacultural Sciences, Centre for Integrative Genetics (CIGENE), Norwegian University of Life Sciences, 1432 Ås, Norway.
authors.forename: Simen Rød
authors.initials: SR
authors.lastname: Sandve
authors.affiliation: Department of Molecular Biology, University of Wyoming, Laramie, WY 82071 USA ; Center for Computational Genetics and Genomics and Department of Biology, Temple University, Philadelphia, PA 19122 USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Liberles