title: Evaluation of quality of life and fatigue in radiologically isolated syndrome.
abstract: BACKGROUND
  Radiologically isolated syndrome (RIS) is a new subtype entity described at the very left of the demyelinating disease spectrum, where spatial dissemination of T2-weighted lesions can be documented on MRI in subjects with no history of neurological symptoms.
  
  
  OBJECTIVE
  This study was a longitudinal assessment of health-related quality of life (HRQOL) and fatigue in RIS patients.
  
  
  METHODS
  Non-converted RIS patients were evaluated at the time of diagnosis, and at 1 and 2 years of follow-up; their scores were compared with scores in clinically isolated syndrome (CIS) patients and age-matched controls.
  
  
  RESULTS
  Sociodemographic characteristics were comparable at baseline. There was no statistical difference between RIS and CIS groups in terms of cerebrospinal fluid (CSF) positivity or T2 lesion load. For HRQOL evaluations, RIS patients scored the same as controls, while CIS patients scored lower. Fatigue was detectable in both RIS and CIS patients compared with baseline and with controls. Mental HRQOL scores decreased significantly for RIS patients during follow-up.
  
  
  CONCLUSIONS
  HRQOL impairment and fatigue were detectable during follow-up in both non-converted RIS and CIS patients.
authors.affiliation: Neurology, Nice University Hospital, 30, voie Romaine, 06000 Nice cedex, France. Electronic address: Lebrun.c@chu-nice.fr.
authors.forename: C
authors.initials: C
authors.lastname: Lebrun
authors.affiliation: Neurology, Nice University Hospital, 30, voie Romaine, 06000 Nice cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Cohen
authors.affiliation: Neurology, Clermont-Ferrand University Hospital, 58, rue Montalembert, 63000 Clermont-Ferrand, France.
authors.forename: P
authors.initials: P
authors.lastname: Clavelou
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003711:Demyelinating Diseases / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D018450:Disease Progression; D005221:Fatigue / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D011788:Quality of Life; D013577:Syndrome; D055815:Young Adult
keywords: Clinically isolated syndrome; Fatigue; Multiple sclerosis; Quality of life; Radiologically isolated syndrome