title: Utility of hypertriglyceridemic waist phenotype for predicting incident type 2 diabetes: The Isfahan Diabetes Prevention Study.
abstract: OBJECTIVE
  We evaluated the association between hypertriglyceridemic waist (HTW) phenotype and the risks of type 2 diabetes in an Iranian high-risk population.
  
  
  METHODS
  We analyzed 7-year follow-up data (n = 1,865) in non-diabetic first-degree relatives of consecutive patients with type 2 diabetes aged 30-70 years. The primary outcome was the diagnosis of type 2 diabetes based on repeated oral glucose tolerance tests. We used multiple logistic regressions to estimate the odds ratio (OR) for incident type 2 diabetes across four groups according to baseline fasting serum triglycerides (TG) level and waist circumference (WC): normal WC and normal TG, normal WC and high TG, enlarged WC and normal TG, and HTW (enlarged WC high TG).
  
  
  RESULTS
  The HTW phenotype at baseline was associated with the incidence of type 2 diabetes. Those with HTW were 2.4-fold (OR 2.36, 95% confidence interval 1.61-3.44), those with normal WC high TG were 1.9-fold (OR 1.87, 95% confidence interval 1.29-2.70) and those with enlarged WC but normal TG were 2.8-fold (OR 2.84, 95% confidence interval 1.96-4.13) more likely to develop type 2 diabetes than those with normal WC and normal TG.
  
  
  CONCLUSIONS
  These data provide further evidence that the HTW phenotype is a robust predictor of type 2 diabetes in high-risk individuals in Iran, and the predictive power is not higher than that of simple enlarged WC and normal TG, emphasizing the importance of enlarged WC to the development of type 2 diabetes.
authors.affiliation: Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. janghorbani@hlth.mui.ac.ir.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Janghorbani
authors.affiliation: Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Amini
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D064250:Hypertriglyceridemic Waist / Q000150:complications / Q000175:diagnosis*; D007492:Iran; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors; D016019:Survival Analysis
keywords: Hypertriglyceridemic waist; Risk factor; Type 2 diabetes