title: Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba L.
abstract: Detailed phytochemical investigation from the root bark of Morus alba resulted in the isolation of eleven new compounds, including seven 2-arylbenzofuran derivatives (morusalfurans A-G), three flavonoids (morusalnols A-C), and one geranylated stilbene (morusibene A), as well as 22 known compounds. The structures of the identified compounds were elucidated based on a comprehensive analysis of spectroscopic data and Mosher's method. Compounds 2, 3, 6-8, 11, 23, 24, and 29 showed potent inhibition of PL in comparison with the positive control treatment (orlistat, IC50=0.012μM), with IC50 values ranging from 0.09 to 0.92μM.
authors.affiliation: College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay District, Hanoi, Vietnam.
authors.forename: Manh Tuan
authors.initials: MT
authors.lastname: Ha
authors.affiliation: College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea.
authors.forename: Manh Hung
authors.initials: MH
authors.lastname: Tran
authors.affiliation: College of Pharmacy, Kyungpook National University, Daegu 702-701, Republic of Korea.
authors.forename: Kim Jeong
authors.initials: KJ
authors.lastname: Ah
authors.affiliation: Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
authors.forename: Kyung-Jin
authors.initials: KJ
authors.lastname: Jo
authors.affiliation: Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
authors.forename: Jaewang
authors.initials: J
authors.lastname: Kim
authors.affiliation: Gyeongsanbuk-do Forest & Environment Research Institute, Gyeongju 780-936, Republic of Korea.
authors.forename: Wook Dong
authors.initials: WD
authors.lastname: Kim
authors.affiliation: Gyeongsanbuk-do Forest & Environment Research Institute, Gyeongju 780-936, Republic of Korea.
authors.forename: Woo Jae
authors.initials: WJ
authors.lastname: Cheon
authors.affiliation: College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea.
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Woo
authors.affiliation: Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Ryu
authors.affiliation: College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk 712-702, Republic of Korea. Electronic address: bsmin@cu.ac.kr.
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
mesh_terms: D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008049:Lipase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015394:Molecular Structure; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D010936:Plant Extracts; D008049:Lipase
keywords: 2-Arylbenzofuran; Geranylated stilbene; Moraceae; Morus alba; Pancreatic lipase