title: Fluorine-18 DOPA-PET and PET/CT Imaging in Congenital Hyperinsulinism.
abstract: Congenital hyperinsulinism is the principle cause of hypoglycemia during infancy but successful treatment is difficult and persistent hypoglycemia carries the risk of neurologic damage. Focal and diffuse abnormalities are the common forms of hyperinsulinism. Identification and localization of focal hyperinsulinism can be cured by partial pancreatectomy. It has been shown that affected pancreatic areas utilize LDOPA in a higher rate than normal pancreatic tissue and, thus, labeling L-DOPA with fluorine-18 (FDOPA) allows functional mapping of hyperinsulinism using PET. This article presents a fundamental overview of the genetics background, pathology, management, and the role of FDOPA-PET imaging in hyperinsulinism.
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, The Children's Hospital of Philadelphia, PA, USA; Department of Radiology, National Liver Institute, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Houseni
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, The Children's Hospital of Philadelphia, PA, USA.
authors.forename: Wichana
authors.initials: W
authors.lastname: Chamroonrat
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, The Children's Hospital of Philadelphia, PA, USA.
authors.forename: Hongming
authors.initials: H
authors.lastname: Zhuang
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, The Children's Hospital of Philadelphia, PA, USA.
authors.forename: MiGuel
authors.initials: M
authors.lastname: Hernandez-Pampolini
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, The Children's Hospital of Philadelphia, PA, USA; Department of Radiology, Hospital of University of Pennsylvania, University of Pennsylvania School of Medicine, 34th & Spruce Street, Philadelphia, PA 19104, USA. Electronic address: abass.alavi@uphs.upenn.edu.
authors.forename: Abass
authors.initials: A
authors.lastname: Alavi
keywords: Congenital hyperinsulinism; FDOPA; PET; PET/CT; Persistent hypoglycemia