title: Human Papilloma virus in Juvenile Nasopharyngeal Angiofibroma: possible recent trend.
abstract: BACKGROUND
  Juvenile nasopharyngeal angiofibroma (JNA) has witnessed a four-fold increase in the incidence at our facility in the current decade as compared to the 1980s. With high global incidence of human pappilloma virus (HPV) related oropharyngeal cancer in India, we hypothesize its implication in JNA as it has not yet been reported.
  
  
  METHODS
  Clinico-Surgical variables of 6 patients of JNA were included for correlation and their tissue samples were subjected to western blotting (WB), polymerase chain reaction and immunoflorescence to demonstrate a definite association with HPV. In addition 6 control samples (adenoids) underwent WB analysis.
  
  
  METHODS
  A universal presence of HPV with JNA is novel 'discovery' and has suggested a possibility of a definite association. Only a single case suggested weak infection. None of the controls suggested infection, thus ruling out the presence of HPV in nasopharynx of normal population.
  
  
  CONCLUSIONS
  With the dawn of this definite association, no specific conclusions can yet be drawn but a whole plethora of questions have emerged with our novel 'discovery'.
authors.affiliation: Department of Otorhinolaryngology, King George Medical University, Lucknow; Department of Obstetrics and Gynaecology, and Department of Medical Genetics King George Medical University, Lucknow; Division of Endocrinology Central Drug Research Institute, Lucknow. Electronic address: amishra_ent@yahoo.com.
authors.forename: Anupam
authors.initials: A
authors.lastname: Mishra
authors.affiliation: Department of Otorhinolaryngology, King George Medical University, Lucknow; Department of Obstetrics and Gynaecology, and Department of Medical Genetics King George Medical University, Lucknow; Division of Endocrinology Central Drug Research Institute, Lucknow.
authors.forename: Monica
authors.initials: M
authors.lastname: Sachadeva
authors.affiliation: Department of Otorhinolaryngology, King George Medical University, Lucknow; Department of Obstetrics and Gynaecology, and Department of Medical Genetics King George Medical University, Lucknow; Division of Endocrinology Central Drug Research Institute, Lucknow.
authors.forename: Ankita
authors.initials: A
authors.lastname: Jain
authors.affiliation: Department of Otorhinolaryngology, King George Medical University, Lucknow; Department of Obstetrics and Gynaecology, and Department of Medical Genetics King George Medical University, Lucknow; Division of Endocrinology Central Drug Research Institute, Lucknow; John Muir Hospital, Walnut Creek, CA, USA.
authors.forename: Nimisha Mishra
authors.initials: NM
authors.lastname: Shukla
authors.affiliation: Department of Otorhinolaryngology, King George Medical University, Lucknow; Department of Obstetrics and Gynaecology, and Department of Medical Genetics King George Medical University, Lucknow; Division of Endocrinology Central Drug Research Institute, Lucknow; Department of Medical Genetics / Obstetrics and Gynaecology, King George Medical University, Lucknow, India.
authors.forename: Amita
authors.initials: A
authors.lastname: Pandey
mesh_terms: D000293:Adolescent; D018322:Angiofibroma / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D000914:Antibodies, Viral / Q000378:metabolism; D015331:Cohort Studies; D004279:DNA, Viral / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D027383:Papillomaviridae / Q000302:isolation & purification*
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral