title: UNUSUALLY STABLE ADDUCT BETWEEN METHANOLYZED AMOXICILLIN OR AMPICILLIN AND THEIR DIKETOPIPERAZINE DERIVATIVES.
abstract: Amoxicillin and ampicillin were subjected to methanolysis. As expected, the methanolysis products were observed by HPLC-ESI-MS. Besides these products, diketopiperazine derivatives were also detected. Additionally, unusually stable adduct formed between the products of methanolysis and diketopiperazine derivatives was also identified. Analogical adducts were detected when ethanolysis was performed instead of methanolysis. HPLC-ESI-MS analysis of the separated adducts confirmed that the adducts were composed of methanolysis products and diketopiperazine derivatives.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kosińska
authors.forename: Rafał
authors.initials: R
authors.lastname: Frański
authors.forename: Magdalena
authors.initials: M
authors.lastname: Frańska
mesh_terms: D000658:Amoxicillin / Q000031:analogs & derivatives / Q000737:chemistry*; D000667:Ampicillin / Q000031:analogs & derivatives / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D054659:Diketopiperazines / Q000737:chemistry*; D004340:Drug Contamination; D004355:Drug Stability; D000432:Methanol / Q000737:chemistry*; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents; D054659:Diketopiperazines; D000667:Ampicillin; D000658:Amoxicillin; D000432:Methanol