title: Effect of left atrial appendage excision on procedure outcome in patients with persistent atrial fibrillation undergoing surgical ablation.
abstract: Catheter ablation is less successful for treatment of persistent atrial fibrillation (PersAF) than for paroxysmal atrial fibrillation. Some studies suggest that left atrial appendage (LAA) isolation in addition to pulmonary vein isolation (PVI) is required to maximize the benefits for PersAF after ablation.
  
  
  
  The purpose of this study was to compare the efficacy and safety of 2 surgical ablation approaches for PersAF via video-assisted thoracoscopy: PVI + box lesion and PVI + box lesion + LAA excision.
  
  
  
  We randomly assigned 176 patients with PersAF to video-assisted thoracoscopic surgical ablation with PVI + box lesion (88 patients) or PVI + box lesion + LAA excision (88 patients). The primary endpoint was freedom from any documented atrial arrhythmia lasting >30 seconds after a single ablation procedure without antiarrhythmic drug (AAD).
  
  
  
  After 18 months of follow-up, 61 of 86 patients (70.9%) assigned to PVI + box lesion were free from recurrent atrial fibrillation compared to 64 of 87 patients (73.6%) assigned to PVI + box lesion + LAA excision after a single ablation procedure without AAD (P = .73). Freedom from any atrial arrhythmia after a single procedure with or without AAD was also nonsignificant (70.9% vs 74.7%, respectively). There were no significant differences between groups with regard to adverse events, including death, transient ischemic attack, stroke, pneumothorax, and hydrothorax.
  
  
  
  Among patients with PersAF, no reduction in the rate of recurrent atrial fibrillation was found when LAA excision was performed in addition to PVI and box lesion during surgical ablation.
authors.affiliation: State Research Institute of Circulation Pathology, Novosibirsk, Russia. Electronic address: abromanov@mail.ru.
authors.forename: Alexander
authors.initials: A
authors.lastname: Romanov
authors.affiliation: State Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors.forename: Evgeny
authors.initials: E
authors.lastname: Pokushalov
authors.affiliation: State Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Elesin
authors.affiliation: State Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Bogachev-Prokophiev
authors.affiliation: State Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Ponomarev
authors.affiliation: State Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors.forename: Denis
authors.initials: D
authors.lastname: Losik
authors.affiliation: State Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors.forename: Sevda
authors.initials: S
authors.lastname: Bayramova
authors.affiliation: State Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors.forename: Artem
authors.initials: A
authors.lastname: Strelnikov
authors.affiliation: State Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors.forename: Vitaliy
authors.initials: V
authors.lastname: Shabanov
authors.affiliation: Clinical Hospital of the Presidential Administration, Moscow, Russia.
authors.forename: Oleg
authors.initials: O
authors.lastname: Pidanov
authors.affiliation: Center of Cardiovascular Surgery, Krasnoyarsk, Russia.
authors.forename: Evgeny
authors.initials: E
authors.lastname: Kropotkin
authors.affiliation: Center of Cardiovascular Surgery, Krasnoyarsk, Russia.
authors.forename: Eduard
authors.initials: E
authors.lastname: Ivanickii
authors.affiliation: State Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors.forename: Alexander
authors.initials: A
authors.lastname: Karaskov
authors.affiliation: University of Rochester School of Medicine & Dentistry, New York, New York.
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Steinberg
mesh_terms: D000368:Aged; D020517:Atrial Appendage / Q000601:surgery*; D001281:Atrial Fibrillation / Q000601:surgery*; D006348:Cardiac Surgical Procedures / Q000379:methods; D017115:Catheter Ablation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011667:Pulmonary Veins / Q000601:surgery*; D012008:Recurrence; D020775:Thoracic Surgery, Video-Assisted; D016896:Treatment Outcome
keywords: Ablation; Atrial fibrillation; Left atrial appendage; Pulmonary vein