title: Pathophysiology of affective disorders: functional interaction of stress hormones and hippocampal excitation.
abstract: An important new study by Kvarta, Bradbrook, Dantrassy, Bailey, and Thompson (J Neurophysiol 114: 1713-1724, 2015) examined the effects of persistent stress and excessive glucocorticoid levels on hippocampal function and emotional behavior in rodents. The authors specifically implicate the temporoammonic pathway as being susceptible to reductions in excitatory function in the context of chronic stress. We discuss the importance of this new finding in the broader context of medication development for major depressive disorder.
authors.affiliation: Department of Physiology, Alcohol & Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
authors.forename: M Adrienne
authors.identifier: 0000-0002-7728-174X
authors.initials: MA
authors.lastname: McGinn
authors.affiliation: Department of Physiology, Alcohol & Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana apahng@lsuhsc.edu.
authors.forename: Amanda R
authors.initials: AR
authors.lastname: Pahng
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000503:physiopathology*; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D019964:Mood Disorders / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D013315:Stress, Psychological / Q000503:physiopathology
chemical_list: D006728:Hormones
keywords: affective disorder; depression; glucocorticoids; glutamate; hippocampus; stress