title: Enantioselective construction of imidazolines having vicinal tetra-substituted stereocenters by direct Mannich reaction of α-substituted α-isocyanoacetates with ketimines.
abstract: The catalytic Mannich reaction of α-substituted α-isocyanoacetates with ketimines has been investigated. A variety of imidazolines containing congested vicinal tetra-substituted stereocenters were obtained in excellent yields with high diastereo- and enantioselectivity using cinchona alkaloid amide/Ni(ii) and base catalysts.
authors.affiliation: Department of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan. snakamur@nitech.ac.jp.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Nakamura
authors.forename: Ryota
authors.initials: R
authors.lastname: Yamaji
authors.forename: Masaru
authors.initials: M
authors.lastname: Iwanaga