title: [Successful treatment of an overwhelming infection with granulocyte transfusion in severe aplastic anemia patient undergoing allogeneic peripheral blood stem cell transplantation].
abstract: A 19-year-old woman complaining of fever and a sore throat was diagnosed with very severe aplastic anemia (AA) by bone marrow examination at a local hospital. Despite administration of antibiotics and granulocyte-colony stimulating factor to treat the soft tissue infection in her neck, her neutrophil count showed no increase. Because emergent allogeneic stem cell transplantation (SCT) was necessary, she was referred to our hospital. On admission, computed tomography revealed right-sided severe pharyngitis and lymphadenitis causing tracheal stenosis, and emergent intubation was required the next day. Granulocyte transfusion therapy (GTX) from related donors coupled with broad-spectrum antibiotic administration controlled the otherwise overwhelming infection. The patient received allogeneic peripheral blood SCT using a reduced-intensity conditioning regimen. After allogeneic SCT, successful engraftment was obtained. She was discharged from the hospital 59 days after allogeneic SCT. She remains alive and well, as of the latest follow up. This case clearly demonstrates that GTX is useful for controlling severe infection and enables patients with severe AA to receive allogeneic SCT safely.
authors.affiliation: Department of Hematology, Kobe City Medical Center General Hospital.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kazuma
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ono
authors.forename: Noboru
authors.initials: N
authors.lastname: Yonetani
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Imai
authors.forename: Manabu
authors.initials: M
authors.lastname: Kawakami
authors.forename: Hisako
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ishikawa
mesh_terms: D000741:Anemia, Aplastic / Q000473:pathology / Q000628:therapy*; D016913:Blood Component Transfusion; D005260:Female; D006098:Granulocytes; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult