title: Mutation Spectra of BRCA Genes in Iranian Women with Early Onset Breast Cancer - 15 Years Experience.
abstract: Breast cancer is the most common cancer in Iran. In the recent years an upward trend has been observed in the Iranian population. Early detection by molecular approaches may reduce breast cancer morbidity and mortality. We provided consultation to 3,782 women diagnosed with early onset breast cancer during the past 15 years (1999-2014). To establish a data set for BRCA gene alterations of the Iranian families at risk, two hundred and fifty four women who met our criteria were analyzed. A total number of 46 alterations including 18 variants with unknown clinical significance (39.1%), 18 missense mutations (39.1%), 7 Indels (15.2%) and 3 large rearrangement sequences (6%) were identified. Further scanning of affected families revealed that 49% of healthy relatives harbor identical causative mutations. This is the first report of comprehensive BRCA analysis in Iranian women with early onset breast cancer. Our findings provide valuable molecular data to support physicians as well as patients for the best decision making on disease management.
authors.affiliation: Genomic Research Center, Department of Medical Genetic,Shahid Beheshti University of Medical Sciences, Tehran, Iran E-mail: v.yassaee-grc@sbmu.ac.ir.
authors.forename: Vahid Reza
authors.initials: VR
authors.lastname: Yassaee
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Ravesh
authors.forename: Ziba
authors.initials: Z
authors.lastname: Soltani
authors.forename: Feyzollah
authors.initials: F
authors.lastname: Hashemi-Gorji
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Poorhosseini
authors.forename: Robab
authors.initials: R
authors.lastname: Anbiaee
authors.forename: Azadeh
authors.initials: A
authors.lastname: Joulaee
mesh_terms: D017668:Age of Onset; D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D009154:Mutation / Q000235:genetics*; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human