title: Sexual function and hormone profile in young adult men with idiopathic gynecomastia: Comparison with healthy controls.
abstract: OBJECTIVE
  To compare sexual function and hormone profile in male patients with gynecomastia with matched controls.
  
  
  METHODS
  Forty-seven male subjects with gynecomastia and thirty healthy controls were enrolled in this study. Serum free T3, free T4, TSH, FSH, prolactin, estradiol, total testosterone, free testosterone, DHEA-SO4, LH and total PSA were measured in the patients and controls. Sexual function of the patients and controls were evaluated using International Index of Erectile Function (IIEF). The hormone values and IIEF scores of the patients were statistically compared with the controls'.
  
  
  RESULTS
  The mean of age, body mass index, right and left testicular volume in the patient and control group were similar. The mean FSH and free T3 values of the patients were significantly lower than the controls (p = 0.007 and p = 0.03, respectively). The mean of the other hormone values in the both groups were found to be statistically similar (p > 0.05). The mean ±SD of total IIEF scores in the patient and control group were 60.14 ± 8.78 and 65.24 ± 5.52, respectively (p = 0.007). Although the mean IIEF-erectile function, orgasmic function and intercourse satisfaction scores in the patient group were significantly lower than the control group (p < 0.001, p = 0.004 and p = 0.001, respectively), the mean IIEF-desire score of the patients was significantly higher than the controls (p = 0.002).
  
  
  CONCLUSIONS
  We found that the hormone profiles (except FSH and free T3) of the patients with gynecomastia were similar with the controls. However, gynecomastia adversely affected male sexual function.
authors.affiliation: Izmir Bozyaka Training and Research Hospital, Plastic and Reconstructive Surgery Clinic, Izmir, Turkey.
authors.forename: Emin
authors.initials: E
authors.lastname: Sir
authors.affiliation: Department of Urology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
authors.forename: Oktay
authors.initials: O
authors.lastname: Üçer
authors.affiliation: Konur Medical Center, Plastic and Reconstructive Surgery Clinic, Bursa, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Aksoy
authors.affiliation: Izmir Bozyaka Training and Research Hospital, Plastic and Reconstructive Surgery Clinic, Izmir, Turkey.
authors.forename: Melike
authors.initials: M
authors.lastname: Güngör
authors.affiliation: Izmir Bozyaka Training and Research Hospital, Urology Clinic, Izmir, Turkey.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Ceylan
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D007172:Erectile Dysfunction / Q000097:blood / Q000453:epidemiology*; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D006177:Gynecomastia / Q000097:blood / Q000453:epidemiology*; D006801:Humans; D007610:Kallikreins / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009948:Orgasm; D010410:Penile Erection; D011388:Prolactin / Q000097:blood; D017430:Prostate-Specific Antigen / Q000097:blood; D060728:Reproductive Health; D020018:Sexual Dysfunctions, Psychological / Q000097:blood / Q000453:epidemiology*; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D055815:Young Adult
chemical_list: D014284:Triiodothyronine; D013739:Testosterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen; D013974:Thyroxine
keywords: Gynecomastia; hormone; sexual health