title: Magnetic Resonance Imaging of Glioma in the Era of Antiangiogenic Therapy.
abstract: Since it supplanted computed tomography in the early 1990s, magnetic resonance (MR) imaging has remained the standard tool to evaluate disease status in patients with brain tumors. With the recent adoption of antiangiogenic therapy for gliomas, it has become increasingly clear that leakiness of the blood-brain barrier, the physiologic correlate of contrast enhancement, is affected by a multitude of pathophysiologic processes, not all of which correlate with tumor burden. To address this issue, physiologic imaging including diffusion and perfusion MR imaging has been investigated as an avenue to acquire predictive and prognostic biomarkers useful in the evaluation of high-grade gliomas.
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 757 Westwood Boulevard, Suite 1621E, Los Angeles, CA 90095, USA.
authors.forename: Sarah N
authors.initials: SN
authors.lastname: Khan
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 757 Westwood Boulevard, Suite 1621E, Los Angeles, CA 90095, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Linetsky
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 757 Westwood Boulevard, Suite 1621E, Los Angeles, CA 90095, USA; Department of Biomedical Physics, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Boulevard, Suite 615, Los Angeles, CA 90024, USA; Department of Biomedical Engineering, David Geffen School of Medicine, University of California Los Angeles, 924 Westwood Boulevard, Suite 615, Los Angeles, CA 90024, USA.
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Ellingson
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 757 Westwood Boulevard, Suite 1621E, Los Angeles, CA 90095, USA. Electronic address: wpope@mednet.ucla.edu.
authors.forename: Whitney B
authors.initials: WB
authors.lastname: Pope