title: A novel marker of ameloblastoma and systematic review of immunohistochemical findings.
abstract: This study aims at investigating the pathogenesis and oncogenesis of ameloblastoma. Being the commonest odontogenic tumor with idiopathic nature, ameloblastoma poses a fierce controversy about its oncogenesis. Immunohistochemical markers, over years, have highlighted specific pathways which are inherently undertaken in the tumorigenic process of ameloblastoma. Besides the recently pronounced clue of BRAF V600E mutant gene, this study introduces a new marker with its outstanding impact on our contemporary knowledge about ameloblastoma. Extrapolating from the systematic review of medical literature and recruiting a novel immunohistochemical marker, ameloblastoma enacts a new scenario supporting the approved involvement of MAPK by overexpressing WT1 a total of 37 archival cases, regardless of the histological variant in study. There evinces a significant contribution of Wilm's tumor gene, as an oncogene rather than a suppressor gene, to the pathogenesis of the ameloblastomatous tumorigenesis. Moreover, no ameloblastomatous histological phenotype has established, given the literature underpinned, a concrete impact on the clinical behavior. Immunohistochemical research papers which investigated tumorigenesis - although they do not quantitatively measure much- had the most significant impact on the diagnostic and prognostic levels. WT1 may play, therefore, a remarkable role in the oncogenesis of ameloblastoma.
authors.affiliation: Department of Maxillofacial Surgery and Diagnosis, Cairo University, Egypt. Electronic address: bacemottoman@gmail.com.
authors.forename: Bacem A E O
authors.initials: BA
authors.lastname: Khalele
authors.affiliation: Department of Maxillofacial Surgery and Diagnosis, Cairo University, Egypt.
authors.forename: Rami A
authors.initials: RA
authors.lastname: Al-Shiaty
mesh_terms: D000564:Ameloblastoma / Q000378:metabolism* / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000378:metabolism; D063646:Carcinogenesis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D009808:Odontogenic Tumors / Q000378:metabolism* / Q000473:pathology; D010641:Phenotype
chemical_list: D014408:Biomarkers, Tumor
keywords: Ameloblastoma; Oncogenesis; Systematic review; Wilm's tumor gene