title: Autoimmune hepatitis following drug-induced liver injury in an elderly patient.
abstract: We describe a case of autoimmune hepatitis (AIH) that may have occurred following drug-induced liver injury with camostat mesilate and/or benzbromarone in an elderly patient. The patient's liver biopsy showed chronic active hepatitis and autoimmune hepatitis. Stopping the use of these drugs did not lead to complete remission, but the use of a low dose of corticosteroids completely cured his liver dysfunction. In the present case, liver dysfunction was caused by an autoimmune mechanism. Special attention should be paid to idiopathic AIH and drug-induced AIH in elderly patients.
authors.affiliation: Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 220-8677, Japan.
authors.forename: Junichiro
authors.initials: J
authors.lastname: Kumagai
authors.affiliation: Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 220-8677, Japan. kandat-cib@umin.ac.jp.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kanda
authors.affiliation: Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 220-8677, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Yasui
authors.affiliation: Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 220-8677, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Haga
authors.affiliation: Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 220-8677, Japan.
authors.forename: Reina
authors.initials: R
authors.lastname: Sasaki
authors.affiliation: Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 220-8677, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 220-8677, Japan.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 220-8677, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Nakamoto
authors.affiliation: Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 220-8677, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Arai
authors.affiliation: Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 220-8677, Japan.
authors.forename: Yotaro
authors.initials: Y
authors.lastname: Iino
authors.affiliation: Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 220-8677, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokosuka
mesh_terms: D000368:Aged; D001553:Benzbromarone / Q000009:adverse effects; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000473:pathology; D004952:Esters; D016670:Gabexate / Q000009:adverse effects / Q000031:analogs & derivatives; D006146:Guanidines; D019693:Hepatitis, Autoimmune / Q000209:etiology* / Q000473:pathology; D006521:Hepatitis, Chronic / Q000209:etiology / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D014528:Uricosuric Agents / Q000009:adverse effects
chemical_list: D004952:Esters; D006146:Guanidines; D014528:Uricosuric Agents; C034532:camostat; D001553:Benzbromarone; D016670:Gabexate
keywords: Autoimmune hepatitis; Benzarone; Benzbromarone; Camostat mesilate