title: Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy.
abstract: Nanoparticles that can efficiently control the differentiation of neural stem cells (NSCs) into neurons are developed for Alzheimer's disease (AD) therapy. The treatment with these nanoparticles results in an attenuation of neuronal loss and rescues memory deficiencies in mice. The system can also be used to monitor the transplantation site, as well as the migration of NSCs in real time. Therefore, the system is proposed to open up new avenues for AD treatment.
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.|College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, 071002, P. R. China.
authors.forename: Ran
authors.initials: R
authors.lastname: Zhang
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Bingbing
authors.initials: B
authors.lastname: Hu
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.|University of Chinese Academy of Science, Beijing, 100190, P. R. China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Lu
authors.affiliation: College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, 071002, P. R. China.
authors.forename: Jinchao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics; D002465:Cell Movement; D065546:Drug Liberation; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage*; D058953:Neural Stem Cells / Q000166:cytology*; D034741:RNA, Small Interfering / Q000008:administration & dosage*; D014212:Tretinoin / Q000008:administration & dosage*
chemical_list: D034741:RNA, Small Interfering; D014212:Tretinoin
keywords: Alzheimer's disease; RNA; interference; magnetic resonance imaging; nanoparticles; neural stem cells