title: [Prognosis prediction of febrile neutropenia by MASCC score: A retrospective study].
abstract: BACKGROUND
  The score of the MASCC, by means of clinical criteria, estimates the risk of serious complications in patients with neutropenic fever induced by chemotherapy.
  
  
  METHODS
  We retrospectively studied a cohort of patients hospitalized for a neutropenic fever and analyzed complications according to the criteria defined by the MASCC.
  
  
  RESULTS
  Eighty-one neutropenic fevers in 71 patients were identified. Microbiological documentation was obtained in 33% of cases only. Fifty-eight patients (72%) presented with a MASCC score≥21 and were considered as low risk of complications. In the total population, 10 patients died during their hospitalizations for neutropenic fever, 7 in the high-risk group versus 3 in the low risk group, including 2 patients suffering from significant comorbidities not taken into account by MASCC score. Within the low risk group, presence of a metastatic disease and existence of 2 or more comorbidities were associated with a longer duration of hospitalization.
  
  
  CONCLUSIONS
  This analysis suggests that the criteria of the MASCC are not always enough to thoroughly identify which patients were at risk of complications or could be treated through outpatient management. By better taking into account the comorbidities and tumoral stage, a better selection of the patients who are likely to receive an ambulatory treatment could be made. To date, hospitalization remains frequently necessary in neutropenic fevers, at least in its initial steps, and the place of the general practitioner remains to be better defined.
authors.affiliation: Hôpital d'instruction des armées du Val-de-Grâce, service d'oncologie et radiothérapie, boulevard du Port-Royal, 75013 Paris, France.
authors.forename: Louise
authors.initials: L
authors.lastname: Cervetti
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Vallard
authors.affiliation: Hôpital d'instruction des armées du Val-de-Grâce, service d'oncologie et radiothérapie, boulevard du Port-Royal, 75013 Paris, France.
authors.forename: Sylvestre
authors.initials: S
authors.lastname: Le Moulec
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Espenel
authors.affiliation: Centre Antoine-Lacassagne, département de radiothérapie, 06189 Nice cedex 02, France.
authors.forename: Alexander Tuan
authors.initials: AT
authors.lastname: Falk
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: Majed
authors.initials: M
authors.lastname: Ben Mrad
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Guy
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: Peng
authors.initials: P
authors.lastname: Diao
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département d'oncologie médicale, 108 bis, avenue Albert-Raimond, BP60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: Benoîte
authors.initials: B
authors.lastname: Méry
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Langrand-Escure
authors.affiliation: Hôpital d'instruction des armées du Val-de-Grâce, service d'oncologie et radiothérapie, boulevard du Port-Royal, 75013 Paris, France.
authors.forename: François-Régis
authors.initials: FR
authors.lastname: Ferrand
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département d'oncologie médicale, 108 bis, avenue Albert-Raimond, BP60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Rivoirard
authors.affiliation: Hôpital d'instruction des armées du Val-de-Grâce, service d'oncologie et radiothérapie, boulevard du Port-Royal, 75013 Paris, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Ceccaldi
authors.affiliation: Hôpital d'instruction des armées du Val-de-Grâce, service d'oncologie et radiothérapie, boulevard du Port-Royal, 75013 Paris, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Védrine
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Magné
authors.affiliation: Hôpital d'instruction des armées du Val-de-Grâce, service d'oncologie et radiothérapie, boulevard du Port-Royal, 75013 Paris, France. Electronic address: chargari-vdg@hotmail.com.
authors.forename: Cyrus
authors.initials: C
authors.lastname: Chargari
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000382:microbiology; D064147:Febrile Neutropenia / Q000139:chemically induced / Q000150:complications* / Q000453:epidemiology / Q000401:mortality; D005602:France / Q000453:epidemiology; D017052:Hospital Mortality; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index
keywords: Cancer; MASCC score; Neutropenic fever; Neutropénie fébrile; Outpatient treatment; Score MASCC; Traitement ambulatoire