title: A comparison of the cardiopulmonary effects of pressure controlled ventilation and volume controlled ventilation in healthy anesthetized dogs.
abstract: OBJECTIVE
  To compare the effects of pressure controlled ventilation (PCV) with volume-controlled ventilation (VCV) on lung compliance, gas exchange, and hemodynamics in isoflurane-anesthetized dogs.
  
  
  METHODS
  Prospective randomized study.
  
  
  METHODS
  Veterinary teaching hospital.
  
  
  METHODS
  Forty client-owned bitches undergoing elective ovariohysterectomy.
  
  
  METHODS
  Dogs were randomly assigned to be ventilated with 100% oxygen using PCV (n = 20) or VCV (n = 20). The respiratory rate was 20/min and positive end-expiratory pressure (PEEP) was 5 cm H2 O, with a tidal volume of 10 mL/kg. Cardiac output (CO) was measured using thermodilution. Cardiopulmonary and blood gas data were obtained during spontaneous ventilation and after 30 (T30) and 60 minutes (T60) of controlled ventilation.
  
  
  RESULTS
  In dogs ventilated with PCV, at T30 and T60, PIP was lower (11.4 ± 1.9 and 11.1 ± 1.5 cm H2 O, respectively) and static compliance (CST ) was higher (51 ± 7 and 56 ± 6 mL/cm H2 O, respectively) than in VCV group (PIP of 14.3 ± 1.3 and 15.5 ± 1.4 cm H2 O; CST of 34 ± 8 and 33 ± 9 mL/cm H2 O, P < 0.0001). Compared with spontaneous ventilation, both groups had decreased alveolar-arterial oxygen difference at T30 and T60 (PCV: 128 ± 32 mm Hg vs 108 ± 20 and 104 ± 16 mm Hg, respectively; VCV: 131 ± 38 mm Hg vs 109 ± 19 and 107 ± 14 mm Hg, respectively; P < 0.01), while CO was maintained at all time points.
  
  
  CONCLUSIONS
  Compared to spontaneous ventilation, both ventilatory modes effectively improved gas exchange without hemodynamic impairment. PCV resulted in higher lung CST and lower PIP compared to VCV.
authors.affiliation: Disciplina de Anestesiologia, Laboratório de Investigação Médica 8, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Denise T
authors.initials: DT
authors.lastname: Fantoni
authors.affiliation: Disciplina de Anestesiologia, Laboratório de Investigação Médica 8, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Keila K
authors.initials: KK
authors.lastname: Ida
authors.affiliation: Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Thomas F T
authors.initials: TF
authors.lastname: Lopes
authors.affiliation: Disciplina de Anestesiologia, Laboratório de Investigação Médica 8, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Denise A
authors.initials: DA
authors.lastname: Otsuki
authors.affiliation: Disciplina de Anestesiologia, Laboratório de Investigação Médica 8, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: José Otávio C
authors.initials: JO
authors.lastname: Auler
authors.affiliation: Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Aline M
authors.initials: AM
authors.lastname: Ambrósio
mesh_terms: D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D002302:Cardiac Output / Q000502:physiology*; D004285:Dogs / Q000502:physiology*; D005260:Female; D007044:Hysterectomy / Q000662:veterinary; D007530:Isoflurane / Q000008:administration & dosage; D008170:Lung Compliance / Q000502:physiology*; D010052:Ovariectomy / Q000662:veterinary; D011175:Positive-Pressure Respiration / Q000662:veterinary; D011446:Prospective Studies; D013990:Tidal Volume / Q000502:physiology*
chemical_list: D007530:Isoflurane
keywords: canine; mechanical ventilation; pulmonary function; respiratory mechanics