title: Respiratory Syncytial Virus and Cellular Stress Responses: Impact on Replication and Physiopathology.
abstract: Human respiratory syncytial virus (RSV), a member of the Paramyxoviridae family, is a major cause of severe acute lower respiratory tract infection in infants, elderly and immunocompromised adults. Despite decades of research, a complete integrated picture of RSV-host interaction is still missing. Several cellular responses to stress are involved in the host-response to many virus infections. The endoplasmic reticulum stress induced by altered endoplasmic reticulum (ER) function leads to activation of the unfolded-protein response (UPR) to restore homeostasis. Formation of cytoplasmic stress granules containing translationally stalled mRNAs is a means to control protein translation. Production of reactive oxygen species is balanced by an antioxidant response to prevent oxidative stress and the resulting damages. In recent years, ongoing research has started to unveil specific regulatory interactions of RSV with these host cellular stress responses. Here, we discuss the latest findings regarding the mechanisms evolved by RSV to induce, subvert or manipulate the ER stress, the stress granule and oxidative stress responses. We summarize the evidence linking these stress responses with the regulation of RSV replication and the associated pathogenesis.
authors.affiliation: CRCHUM-Centre Hospitalier de l'Université de Montréal, Montréal, QC H2X 0A9, Canada. s.l.cervantes.ortiz@umontreal.ca.|Faculty of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada. s.l.cervantes.ortiz@umontreal.ca.|Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, QC H3C 3J7, Canada. s.l.cervantes.ortiz@umontreal.ca.
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Cervantes-Ortiz
authors.affiliation: CRCHUM-Centre Hospitalier de l'Université de Montréal, Montréal, QC H2X 0A9, Canada. Natalia.zamorano@umontreal.ca.|Faculty of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada. Natalia.zamorano@umontreal.ca.
authors.forename: Natalia
authors.initials: N
authors.lastname: Zamorano Cuervo
authors.affiliation: CRCHUM-Centre Hospitalier de l'Université de Montréal, Montréal, QC H2X 0A9, Canada. nathalie.grandvaux@umontreal.ca.|Faculty of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada. nathalie.grandvaux@umontreal.ca.|Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada. nathalie.grandvaux@umontreal.ca.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Grandvaux
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress; D054884:Host-Pathogen Interactions; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism; D018113:Respiratory Syncytial Virus, Human / Q000502:physiology*; D013312:Stress, Physiological; D056811:Unfolded Protein Response; D014779:Virus Replication
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species
keywords: ER stress; RSV; endoplasmic reticulum; inclusion bodies; oxidative stress; reactive oxygen species; respiratory syncytial virus; stress granule; stress response; virus