title: Circulating Anti-Müllerian Hormone Levels in Daughters of Women with and without Polycystic Ovary Syndrome.
abstract: OBJECTIVE
  The aim of this study was to assess whether circulating anti-Müllerian hormone (AMH) levels in daughters of women with polycystic ovary syndrome (PCOSd) correspond with clinical and biochemical features of hyperandrogenism, polycystic ovary morphology and menstrual cycle disturbances.
  
  
  METHODS
  Menstrual cycle disturbances, hirsutism, acne and ultrasonographic ovarian morphology were assessed in 75 girls aged 13-18 years (35 PCOSd and 40 daughters of healthy women). Serum gonadotropins, androgens, sex hormone-binding globulin and plasma AMH were measured in a fasting state, and the free androgen index was calculated.
  
  
  RESULTS
  A significant correlation between the AMH level and mean ovary volume was found (r = 0.36; p < 0.01). AMH levels were not related to hirsutism, acne and polycystic ovary morphology. Significantly higher AMH levels were found only in PCOSd with irregular menstruation or secondary amenorrhea. The results of logistic regression analysis showed that in that group for each 1-ng/ml increase in the AMH level, the odds ratio of the PCOS occurrence in the future was increased 1.27 times (95% CI: 1.09-1.47; p < 0.01).
  
  
  CONCLUSIONS
  A higher AMH level in PCOSd is associated with menstrual cycle disturbances and larger ovarian volume but not with clinical and biochemical features of hyperandrogenism. Thus, the risk for PCOS development among genetically predisposed girls may be related to increased AMH levels.
authors.affiliation: Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medicine, Medical University of Silesia, Katowice, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Olszanecka-Glinianowicz
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Zachurzok
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Drosdzol-Cop
authors.forename: Maria
authors.initials: M
authors.lastname: Bożętowicz-Wikarek
authors.forename: Aleksander
authors.initials: A
authors.lastname: Owczarek
authors.forename: Aneta
authors.initials: A
authors.lastname: Gawlik
authors.forename: Jerzy
authors.initials: J
authors.lastname: Chudek
authors.forename: Violetta
authors.initials: V
authors.lastname: Skrzypulec-Plinta
authors.forename: Ewa
authors.initials: E
authors.lastname: Małecka-Tendera
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000097:blood*; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D006801:Humans; D008598:Menstruation / Q000097:blood*; D008875:Middle Aged; D010053:Ovary / Q000378:metabolism / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000473:pathology
chemical_list: D054304:Anti-Mullerian Hormone