title: Local disinfection with sodium hypochlorite as adjunct to basic periodontal therapy: a randomized controlled trial.
abstract: To investigate the clinical and microbiological effects of local disinfection with 0.5% sodium hypochlorite (NaOCl) with or without systemic antimicrobials (amoxicillin and metronidazole, AM) during basic periodontal therapy (BPT).
  
  
  
  In a randomized clinical trial (four groups), 110 chronic periodontitis patients received BPT plus local irrigation with saline (BPT + S), local disinfection with NaOCl (BPT + DIS), BPT + DIS + AM or BPT + S + AM. The outcome was analysed at baseline, 3, 6 and 12 months.
  
  
  
  There was no difference in clinical attachment level gain at 12 months between the four groups. BPT + DIS showed no additional improvement compared to BPT + S; BPT + DIS + AM showed fewer sites with probing pocket depth (PPD) ≥7 mm versus BPT + S only up to 6 months (p = 0.037). In factorial analyses, additional clinical reduction for PPD (p = 0.023) and number of sites with PPD ≥5 (p = 0.007), ≥6 (p = 0.002) and ≥7 mm (p < 0.001) were found when AM was added to BPT, but not when DIS was applied. In all groups, a comparable decrease in targeted bacteria was found. AM caused adverse events in 22% of the patients.
  
  
  
  Local disinfection with NaOCl, also in combination with AM, showed, after 1-year follow-up, no additional clinical and microbiological effects compared to BPT alone.
authors.affiliation: Department of Periodontology, Academic Centre for Dentistry of Amsterdam (ACTA), University of Amsterdam and VU University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Sergio
authors.initials: S
authors.lastname: Bizzarro
authors.affiliation: Department of Periodontology, Academic Centre for Dentistry of Amsterdam (ACTA), University of Amsterdam and VU University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Ubele
authors.initials: U
authors.lastname: Van der Velden
authors.affiliation: Department of Periodontology, Academic Centre for Dentistry of Amsterdam (ACTA), University of Amsterdam and VU University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Bruno G
authors.initials: BG
authors.lastname: Loos
mesh_terms: D000658:Amoxicillin; D000900:Anti-Bacterial Agents; D012534:Dental Scaling; D004203:Disinfection; D005500:Follow-Up Studies; D006801:Humans; D008795:Metronidazole; D010510:Periodontal Diseases; D012973:Sodium Hypochlorite
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D000658:Amoxicillin; D012973:Sodium Hypochlorite
keywords: amoxicillin; metronidazole; periodontitis; scaling and root planing; sodium hypochlorite