title: Houttuynia cordata Thunb reverses oxaliplatin-induced neuropathic pain in rat by regulating Th17/Treg balance.
abstract: Oxaliplatin is a widely used anti-advanced colorectal cancer drug, while it could induce neuropathy. Houttuynia cordata Thunb (HCT) has a wide range of biological activities, such as anti-inflammation, anti-cancer, and immune regulation. In the present study, we investigated the effect of HCT on oxaliplatin-induced neuropathy in rat models. HCT (1000 mg/kg/day) significantly decreased the number of withdrawal responses and the withdrawal latency in oxaliplatin-treated rats. HCT could down-regulated the serum levels of Interleukin-6 (IL-6) and macrophage inflammatory protein1-α (MIP-1α) in oxaliplatin-treated rats. Th17/Treg balance was reversed by HCT in oxaliplatin-treated rats by regulating PI3K/Akt/mTOR signaling pathway. The present results suggest that HCT is useful as a therapeutic drug for oxaliplatin-induced neuropathic pain.
authors.affiliation: Department of Anesthesiology, The First Hospital of China Medical University Shenyang City, Liaoning Province, P. R. China.
authors.forename: Cheng-Fu
authors.initials: CF
authors.lastname: Wan
authors.affiliation: Department of Endocrinology, The 4th Affiliated Hospital of China Medical University Shenyang City, P. R. China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Zheng
authors.affiliation: Department of Anesthesiology, The First Hospital of China Medical University Shenyang City, Liaoning Province, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, The First Hospital of China Medical University Shenyang City, Liaoning Province, P. R. China.
authors.forename: Xue
authors.initials: X
authors.lastname: Yu
keywords: Houttuynia cordata Thunb; Oxaliplatin; PI3K/Akt/mTOR; Th17/Treg; neuropathic pain