title: Neutrophil-to-Lymphocyte Ratio Increases in Patients With Dry Eye.
abstract: OBJECTIVE
  To assess the neutrophil-to-lymphocyte ratio (NLR) as an indicator of inflammation in patients with non-Sjögren dry eye disease.
  
  
  METHODS
  Serum NLR and C-reactive protein values were determined in 33 patients with dry eye and in 32 controls. The NLR was calculated by dividing the neutrophil count by the lymphocyte count.
  
  
  RESULTS
  Characteristics of the dry eye and control groups were similar. The mean NLR value was 2.8 ± 1.4 (range: 1.1-6.1) in the dry eye group and 1.6 ± 0.7 (range: 0.8-2.8) in the control group (P = 0.002, t test). The mean C-reactive protein value was 0.6 ± 0.7 mg/dL (range: 0-2.3 mg/dL) in the dry eye group and 0.5 ± 0.6 mg/dL (range: 0-1.9 mg/dL) in the control group (P = 0.307, t test).
  
  
  CONCLUSIONS
  The NLR values were found to be higher in patients with non-Sjögren dry eye than in controls. This result suggests that non-Sjögren dry eye disease may be associated with systemic inflammation or the NLR values may increase in local inflammatory ocular diseases.
authors.affiliation: Department of Ophthalmology, Recep Tayyip Erdogan University Medical School, Rize, Turkey.
authors.forename: Berrak
authors.initials: B
authors.lastname: Sekeryapan
authors.forename: Feyzahan
authors.initials: F
authors.lastname: Uzun
authors.forename: Seyma
authors.initials: S
authors.lastname: Buyuktarakci
authors.forename: Asker
authors.initials: A
authors.lastname: Bulut
authors.forename: Veysi
authors.initials: V
authors.lastname: Oner
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism; D015352:Dry Eye Syndromes / Q000097:blood*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology*; D011446:Prospective Studies; D011795:Surveys and Questionnaires
chemical_list: D002097:C-Reactive Protein