title: Effects of ischemic postconditioning on expressions of pentraxin-related protein 3 and neutrophil CD11b in the plasma of patients with acute myocardial infarction after percutaneous coronary intervention.
abstract: OBJECTIVE
  To evaluate the effects of ischemic postconditioning on expressions of pentraxin-related protein 3 (PTX3) and neutrophil CD11b in the plasma of patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).
  
  
  METHODS
  Fifty-six patients who had AMI with ST-segment elevation were randomly divided into a control group and an ischemic postconditioning group (n=28). Both groups received emergency PCI. After recanalization of infarct-related arteries, the control group did not receive intervention within three minutes, while the ischemic postconditioning group was treated by low-pressure filling and emptying of balloon within one minute. The plasma expressions of PTX3 before and 24 hour after PCI were detected by ELISA, and those of neutrophil CD11b were detected by flow cytometry.
  
  
  RESULTS
  PTX3 and neutrophil CD11b expressions of the two groups were similar before PCI, but those of the ischemic postconditioning group significantly decreased 24 hour after PCI (P<0.05).
  
  
  CONCLUSIONS
  Ischemic postconditioning lowered the expressions of PTX3 and neutrophil CD11b in AMI patients after PCI, inhibited inflammatory response, reduced the adhesion between leukocytes and endothelial cells, and protected the ischemic-reperfused myocardium.
authors.affiliation: Sheng-Hui Liu, Department of Cardiology, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Sheng-Hui
authors.initials: SH
authors.lastname: Liu
authors.affiliation: Yu-E Huo, Department of Cardiology, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Yu-E
authors.initials: YE
authors.lastname: Huo
authors.affiliation: Xin-Wei Jia, Department of Cardiology, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Xin-Wei
authors.initials: XW
authors.lastname: Jia
authors.affiliation: Ya Li, Department of Cardiology, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Li
keywords: Cell adhesion molecule; Ischemic postconditioning; Myocardial infarction; Neutrophil; Pentraxin-related protein 3