title: Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi.
abstract: BACKGROUND
  Glioblastoma multiforme (GBM) is the deadliest malignant primary brain tumor in adults. GBM develops primarily in the cerebral hemispheres but can develop in other parts of the central nervous system. Its congenital variant is a very rare disease with few cases described in literature.
  
  
  METHODS
  We describe the case of a patient with congenital GBM who developed eruptive disseminated Spitz nevi (EDSN) after chemotherapy. Few cases of EDSN have been described in literature and this rare clinical variant, which occurs predominantly in adults, is characterized by multiple Spitz nevi in the trunk, buttocks, elbows and knees. There is no satisfactory treatment for EDSN and the best therapeutic choice is considered the clinical observation of melanocytic lesions.
  
  
  CONCLUSIONS
  We recommend a close follow-up of these patients with clinical observation, dermoscopy and reflectance confocal microscopy (RCM). However, we suggest a surgical excision of the lesions suspected of being malignant.
authors.affiliation: Department of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Dermatology Unit, University of Modena and Reggio Emilia, via del Pozzo 71, Modena, 41124, Italy.
authors.forename: Victor Desmond
authors.initials: VD
authors.lastname: Mandel
authors.affiliation: Department of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Dermatology Unit, University of Modena and Reggio Emilia, via del Pozzo 71, Modena, 41124, Italy.
authors.forename: Flavia
authors.initials: F
authors.lastname: Persechino
authors.affiliation: Unità Operativa di Terapia Intensiva Neonatale, Dipartimento Integrato Materno-Infantile, Azienda Ospedaliero-Universitaria Policlinico, via del Pozzo 71, Modena, 41124, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Berardi
authors.affiliation: Department of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Clinical Pathology Unit, University of Modena and Reggio Emilia, via del Pozzo 71, Modena, 41124, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ponti
authors.affiliation: Department of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Dermatology Unit, University of Modena and Reggio Emilia, via del Pozzo 71, Modena, 41124, Italy.
authors.forename: Silvana
authors.initials: S
authors.lastname: Ciardo
authors.affiliation: Terapia Intensiva Neonatale, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico-IRCCS, viale Risorgimento 80, Reggio Emilia, 42123, Italy. cecilia.rossi@asmn.re.it.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Rossi
authors.affiliation: Department of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Dermatology Unit, University of Modena and Reggio Emilia, via del Pozzo 71, Modena, 41124, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pellacani
authors.affiliation: Department of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Dermatology Unit, University of Modena and Reggio Emilia, via del Pozzo 71, Modena, 41124, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Farnetani
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D001034:Apgar Score; D001932:Brain Neoplasms / Q000151:congenital / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D046169:Dermoscopy / Q000379:methods; D005500:Follow-Up Studies; D005865:Gestational Age; D005909:Glioblastoma / Q000151:congenital / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D019635:Neurosurgical Procedures / Q000379:methods; D018332:Nevus, Epithelioid and Spindle Cell / Q000139:chemically induced / Q000473:pathology*; D035583:Rare Diseases; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000139:chemically induced / Q000473:pathology*; D016896:Treatment Outcome
keywords: Chemotherapy; Congenital glioblastoma multiforme; Eruptive disseminated Spitz nevi; Reflectance confocal microscopy; Spitz nevi