title: The efficiency of multiparametric magnetic resonance imaging (mpMRI) using PI-RADS Version 2 in the diagnosis of clinically significant prostate cancer.
abstract: OBJECTIVE
  To investigate the efficiency of multiparametric MRI (mpMRI) based on Prostate Imaging Reporting and Data System (PI-RADS) Version 2 (v2) in detecting clinically significant prostate cancer (PCa) and to test the interobserver consistency.
  
  
  METHODS
  Based on PI-RADS v2, two radiologists reviewed the images of 372 patients who underwent prostate biopsy and prebiopsy mpMRI.
  
  
  RESULTS
  There's significant correlation between higher PI-RADS score and the presence of clinical significant PCa (P<.001). PI-RADS score 3 was the best cutoff point with sensitivity and specificity over 80%. The diagnostic concordance was moderate (kappa=0.478).
  
  
  CONCLUSIONS
  PI-RADS v2 demonstrated good accuracy in detecting clinically significant PCa, however the interobserver consistency needs to be improved.
authors.affiliation: Department of Radiology, Peking University First Hospital, Beijing, China. Electronic address: chenglin.zhao@163.com.
authors.forename: Chenglin
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Radiology, Peking University First Hospital, Beijing, China. Electronic address: effie_gao@163.com.
authors.forename: Ge
authors.initials: G
authors.lastname: Gao
authors.affiliation: Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China. Electronic address: fdmailbox@126.com.
authors.forename: Dong
authors.initials: D
authors.lastname: Fang
authors.affiliation: Department of Radiology, Peking University First Hospital, Beijing, China. Electronic address: redwindowlfy@163.com.
authors.forename: Feiyu
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Radiology, Peking University First Hospital, Beijing, China. Electronic address: yangxuedong1@163.com.
authors.forename: Xuedong
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Radiology, Peking University First Hospital, Beijing, China. Electronic address: jimmy9527@126.com.
authors.forename: He
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China. Electronic address: bdyyqhe@sina.com.
authors.forename: Qun
authors.initials: Q
authors.lastname: He
authors.affiliation: Department of Radiology, Peking University First Hospital, Beijing, China. Electronic address: cjr.wangxiaoying@vip.163.com.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Wang
mesh_terms: D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D015203:Reproducibility of Results
keywords: Diagnosis; Magnetic resonance imaging; Prostate cancer; Sensitivity; Specificity