title: [Autoreactive TCD8+ lymphocytes in patients with chronic myeloid leukemia in association with HLA and adenovirus infection].
abstract: A possible interaction between a specific HLA type and Adenovirus has been postulated as a promoter in leukemia clonal evolution. The HLA-DRB1*14, specifically DRB1*14:21, 14:22, 14:45, 14:26, 14:33, 14:51, 14:35 subtypes was the most frequent in CML Venezuelan patients.
  
  
  
  It is interesting to evaluate the molecular mimicry between the Adenovirus and the DRB1*14 subtypes which exhibit the same change in the amino acid position of the DR53 epitope. This mimicked segment has been identified as a LLERRRA polypeptide.
  
  
  
  Experimental research conducted in the IHO Venezuela, in peripheral blood samples of patients with ALL, CML and healthy controls. Mixed culture, serology, lymphocyte proliferation and cytofluorometry were performed.
  
  
  
  DRB1*14 patient's lymphocytes reacted in 48 hours mixed culture against DRB1*14 promoters lymphocytes exhibiting increased CD8+T lymphocytes. CML patients show a different serological profile against Adenovirus. Only CML patients reacted to LLERRRA peptide, increasing CD8+ T cells.
  
  
  
  It is established that the relationship CML, HLADRB1* 14, autoreactive CD8+ T memory cell and CD8+T specific response from Adenovirus could be at the origin of the CML in Venezuelan patients.
authors.affiliation: Universidad del Zulia, Maracaibo, Venezuela. sergio.rivera54@hotmail.es.
authors.forename: Sergio E
authors.initials: SE
authors.lastname: Rivera
authors.forename: Miriam
authors.initials: M
authors.lastname: Echeverría
authors.forename: Pedro
authors.initials: P
authors.lastname: Salcedo
authors.forename: Georgina
authors.initials: G
authors.lastname: Márquez
authors.forename: Zuhey
authors.initials: Z
authors.lastname: Carrillo
authors.forename: Yennis
authors.initials: Y
authors.lastname: Parra
authors.forename: Ana María
authors.initials: AM
authors.lastname: Cipriani
authors.forename: José R
authors.initials: JR
authors.lastname: Núñez
authors.forename: Melchor
authors.initials: M
authors.lastname: Álvarez de Mon
authors.forename: Atilio
authors.initials: A
authors.lastname: Farruco
mesh_terms: D000257:Adenoviridae Infections / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016022:Case-Control Studies; D059811:HLA-DRB1 Chains / Q000276:immunology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology* / Q000821:virology; D018716:Molecular Mimicry; D014687:Venezuela
chemical_list: D059811:HLA-DRB1 Chains
keywords: HLA association and disease; TCD4+; adenovirus; leukemias