title: Association of Brachial-Ankle Pulse Wave Velocity with Asymptomatic Intracranial Arterial Stenosis in Hypertension Patients.
abstract: BACKGROUND
  Intracranial arterial stenosis is a common cause of ischemic stroke in Asians. We therefore sought to explore the relationship of brachial-ankle pulse wave velocity and intracranial arterial stenosis in 834 stroke-free hypertensive patients.
  
  
  METHODS
  Intracranial arterial stenosis was evaluated through computerized tomographic angiography. Brachial-ankle pulse wave velocity was measured by an automated cuff device.
  
  
  RESULTS
  The top decile of brachial-ankle pulse wave velocity was significantly associated with intracranial arterial stenosis (P = .027, odds ratio = 1.82; 95% confidence interval: 1.07-3.10). The patients with the top decile of brachial-ankle pulse wave velocity showed 56% higher risk for the presence of intracranial arterial stenosis to the whole population, which was more significant in patients younger than 65 years old. We also found that brachial-ankle pulse wave velocity related to both intracranial arterial stenosis and homocysteine.
  
  
  CONCLUSIONS
  Our study showed the association of brachial-ankle pulse wave velocity with asymptomatic intracranial arterial stenosis in hypertension patients, especially in relative younger subjects. Brachial-ankle pulse wave velocity might be a relatively simple and repeatable measurement to detect hypertension patients in high risk of intracranial arterial stenosis.
authors.affiliation: Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, Research Center for Hypertension Management and Prevention in Community, Shanghai Institute of Hypertension, Shanghai, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, Research Center for Hypertension Management and Prevention in Community, Shanghai Institute of Hypertension, Shanghai, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, Research Center for Hypertension Management and Prevention in Community, Shanghai Institute of Hypertension, Shanghai, China.
authors.forename: Yuesheng
authors.initials: Y
authors.lastname: Qain
authors.affiliation: Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, Research Center for Hypertension Management and Prevention in Community, Shanghai Institute of Hypertension, Shanghai, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Huawei
authors.initials: H
authors.lastname: Ling
authors.affiliation: Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Kemin
authors.initials: K
authors.lastname: Chen
authors.affiliation: Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, Research Center for Hypertension Management and Prevention in Community, Shanghai Institute of Hypertension, Shanghai, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, Research Center for Hypertension Management and Prevention in Community, Shanghai Institute of Hypertension, Shanghai, China.
authors.forename: Pingjin
authors.initials: P
authors.lastname: Gao
authors.affiliation: Shanghai Key Laboratory of Hypertension, State Key Laboratory of Medical Genomics, Research Center for Hypertension Management and Prevention in Community, Shanghai Institute of Hypertension, Shanghai, China. Electronic address: zhudingliang@sibs.ac.cn.
authors.forename: Dingliang
authors.initials: D
authors.lastname: Zhu
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D001783:Blood Flow Velocity / Q000502:physiology*; D001916:Brachial Artery / Q000503:physiopathology*; D002539:Cerebral Arterial Diseases / Q000150:complications* / Q000175:diagnosis; D002681:China; D000072226:Computed Tomography Angiography; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis / Q000379:methods*
keywords: Chinese population; Intracranial arterial stenosis; brachial-ankle PWV; homocysteine; hypertension