title: Case control study of ANKK1 Taq 1A polymorphism in patients with alcohol dependence classified according to Lesch's typology.
abstract: OBJECTIVE
  The aim of this study was to examine the association between the Taq 1A polymorphism of the ANKK1 gene in homogeneous subgroups of patients with alcohol dependence syndrome divided according to Lesch's typology.
  
  
  METHODS
  DNA was provided from alcohol-dependent (AD) patients (n = 373) and healthy control subjects (n = 168), all of Polish descent. The history of alcoholism was obtained using the Polish version of the SSAGA (Semi-Structured Assessment for the Genetics of Alcoholism). Samples were genotyped using the PCR method.
  
  
  RESULTS
  We found no association between alcohol dependence and ANKK1 Taq 1A polymorphism.
  
  
  CONCLUSIONS
  Lesch's typology is a clinical consequence of the disease, and its phenotypic description is too complex for simple genetic analysis.
authors.affiliation: University of Szczecin, Institute of Psychology, Department of Clinical Psychology and Mental Health, Szczecin, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Samochowiec
authors.affiliation: University of Szczecin, Institute of Psychology, Department of Clinical Psychology and Mental Health, Szczecin, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Chęć
authors.affiliation: University Center for Education, University of Szczecin, Poland.
authors.forename: Edyta
authors.initials: E
authors.lastname: Kopaczewska
authors.affiliation: Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Samochowiec
authors.affiliation: Department of Psychiatry, Vienna University, Austria.
authors.forename: Otto
authors.initials: O
authors.lastname: Lesch
authors.affiliation: Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Jasiewicz
authors.affiliation: Department of Nursing, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Grochans
authors.affiliation: Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Jabłoński
authors.affiliation: Institute of Psychiatry and Neurology, Department of Pharmacology, Warszawa, Poland.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Bieńkowski
authors.affiliation: Department of Orthopedics, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Kołodziej
authors.affiliation: Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Grzywacz
mesh_terms: D000437:Alcoholism / Q000145:classification / Q000235:genetics*; D016022:Case-Control Studies; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: C489948:ANKK1 protein, human; D017346:Protein Serine-Threonine Kinases