title: Regulation of Irregular Neuronal Firing by Autaptic Transmission.
abstract: The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the modulation of irregular neuronal firing, primarily by regulating the occurrence frequency of burst firing. In particular, we find that both excitatory and electrical autapses increase the occurrence of burst firing, thus reducing neuronal firing regularity. In contrast, inhibitory autapses suppress burst firing and therefore tend to improve the regularity of neuronal firing. Importantly, we show that these findings are independent of the firing properties of individual neurons, and as such can be observed for neurons operating in different modes. Our results provide an insightful mechanistic understanding of how different types of autapses shape irregular firing at the single-neuron level, and they highlight the functional importance of autaptic self-innervation in taming and modulating neurodynamics.
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China.|Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China.
authors.forename: Daqing
authors.initials: D
authors.lastname: Guo
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China.
authors.forename: Shengdun
authors.initials: S
authors.lastname: Wu
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Physics, Faculty of Natural Sciences and Mathematics, University of Maribor, Maribor, Slovenia.
authors.forename: Matjaž
authors.initials: M
authors.lastname: Perc
authors.affiliation: School of Computer Science and Technology, Southwest University of Science and Technology, Mianyang, China.
authors.forename: Yangsong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China.
authors.forename: Jingling
authors.initials: J
authors.lastname: Ma
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China.|Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xu
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China.|Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China.|Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China.
authors.forename: Dezhong
authors.initials: D
authors.lastname: Yao
mesh_terms: D000200:Action Potentials; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D009435:Synaptic Transmission