title: moviEEG: An animation toolbox for visualization of intracranial electroencephalography synchronization dynamics.
abstract: We introduce and describe the functions of moviEEG (Multiple Overlay Visualizations for Intracranial ElectroEncephaloGraphy), a novel MATLAB-based toolbox for spatiotemporal mapping of network synchronization dynamics in intracranial electroencephalography (iEEG) data.
  
  
  
  The toolbox integrates visualizations of inter-electrode phase-locking relationships in peri-ictal epileptogenic networks with signal spectral properties and graph-theoretical network measures overlaid upon operating room images of the electrode grid. Functional connectivity between every electrode pair is evaluated over a sliding window indexed by phase synchrony.
  
  
  
  Two case studies are presented to provide preliminary evidence for the application of the toolbox to guide network-based mapping of epileptogenic cortex and to distinguish these regions from eloquent brain networks. In both cases, epileptogenic cortex was visually distinct.
  
  
  
  We introduce moviEEG, a novel toolbox for animation of oscillatory network dynamics in iEEG data, and provide two case studies showing preliminary evidence for utility of the toolbox in delineating the epileptogenic zone.
  
  
  
  Despite evidence that atypical network synchronization has shown to be altered in epileptogenic brain regions, network based techniques have yet to be incorporated into clinical pre-surgical mapping. moviEEG provides a set of functions to enable easy visualization with network based techniques.
authors.affiliation: Faculty of Applied Science and Engineering, University of Toronto, Canada; Neuroscience & Mental Health Program, Hospital for Sick Children Research Institute, Canada; Department of Diagnostic Imaging, Hospital for Sick Children, Canada. Electronic address: simeon.wong@sickkids.ca.
authors.forename: Simeon M
authors.initials: SM
authors.lastname: Wong
authors.affiliation: Division of Neurosurgery, Hospital for Sick Children, Canada; Institute of Medical Science, University of Toronto, Canada.
authors.forename: George M
authors.initials: GM
authors.lastname: Ibrahim
authors.affiliation: Division of Neurology, Hospital for Sick Children, Canada.
authors.forename: Ayako
authors.initials: A
authors.lastname: Ochi
authors.affiliation: Division of Neurology, Hospital for Sick Children, Canada.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Otsubo
authors.affiliation: Division of Neurosurgery, Hospital for Sick Children, Canada.
authors.forename: James T
authors.initials: JT
authors.lastname: Rutka
authors.affiliation: Neuroscience & Mental Health Program, Hospital for Sick Children Research Institute, Canada; Institute of Medical Science, University of Toronto, Canada; Division of Neurology, Hospital for Sick Children, Canada.
authors.forename: O Carter
authors.initials: OC
authors.lastname: Snead
authors.affiliation: Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Canada.
authors.forename: Sam M
authors.initials: SM
authors.lastname: Doesburg
mesh_terms: D058407:Electroencephalography Phase Synchronization / Q000502:physiology*; D006801:Humans; D012984:Software
keywords: Epilepsy; Functional connectivity; MATLAB toolbox; Networks; Phase synchrony; Presurgical mapping; iEEG