title: Autoimmune Limbic Encephalitis and Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Lamotrigine-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome.
abstract: Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe drug hypersensitivity reaction characterized by rash, fever and multi-organ failure. Limbic encephalitis (LE) is a rare disorder characterized by cognitive dysfunction with memory disturbance, seizures and psychiatric symptoms. We herein present an unusual case of DRESS syndrome due to lamotrigine with reactivation of Epstein-Barr virus, which developed autoimmune LE and syndrome of inappropriate antidiuretic hormone secretion. Discontinuation of lamotrigine, administration of methylprednisolone and intravenous immunoglobulin led to improvement. The LE in this case might have been caused by an autoimmune inflammatory mechanism associated with DRESS syndrome.
authors.affiliation: Department of Internal Medicine, Hacettepe University Faculty of Medicine, Turkey.
authors.forename: Lale
authors.initials: L
authors.lastname: Ozisik
authors.forename: Mine Durusu
authors.initials: MD
authors.lastname: Tanriover
authors.forename: Esen
authors.initials: E
authors.lastname: Saka
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects; D001327:Autoimmune Diseases / Q000150:complications*; D004342:Drug Hypersensitivity / Q000150:complications* / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced / Q000150:complications; D005076:Exanthema / Q000139:chemically induced / Q000150:complications; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000150:complications*; D000077213:Lamotrigine; D020363:Limbic Encephalitis / Q000150:complications*; D013577:Syndrome; D014227:Triazines / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine