title: Induced pluripotent stem cells in Alzheimer's disease: applications for disease modeling and cell-replacement therapy.
abstract: Alzheimer's disease (AD) is the most common cause of dementia in those over the age of 65. While a numerous of disease-causing genes and risk factors have been identified, the exact etiological mechanisms of AD are not yet completely understood, due to the inability to test theoretical hypotheses on non-postmortem and patient-specific research systems. The use of recently developed and optimized induced pluripotent stem cells (iPSCs) technology may provide a promising platform to create reliable models, not only for better understanding the etiopathological process of AD, but also for efficient anti-AD drugs screening. More importantly, human-sourced iPSCs may also provide a beneficial tool for cell-replacement therapy against AD. Although considerable progress has been achieved, a number of key challenges still require to be addressed in iPSCs research, including the identification of robust disease phenotypes in AD modeling and the clinical availabilities of iPSCs-based cell-replacement therapy in human. In this review, we highlight recent progresses of iPSCs research and discuss the translational challenges of AD patients-derived iPSCs in disease modeling and cell-replacement therapy.
authors.affiliation: Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 200031, Shanghai, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Yang
authors.affiliation: Center for Translational Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, 116021, Dalian, China.
authors.forename: Song
authors.initials: S
authors.lastname: Li
authors.affiliation: Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China.
authors.forename: Xi-Biao
authors.initials: XB
authors.lastname: He
authors.affiliation: Center for Translational Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, 116021, Dalian, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Cheng
authors.affiliation: Center for Translational Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, 116021, Dalian, China. wdle@sibs.ac.cn.|Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, 200031, Shanghai, China. wdle@sibs.ac.cn.|Collaborative Innovation Center for Brain Science, the First Affiliated Hospital, Dalian Medical University, 116011, Dalian, China. wdle@sibs.ac.cn.
authors.forename: Weidong
authors.initials: W
authors.lastname: Le
mesh_terms: D000544:Alzheimer Disease; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D033581:Stem Cell Transplantation
keywords: Alzheimer’s disease; Cell-replacement therapy; Disease modeling; Drugs screening; Induced pluripotent stem cells