title: Baseline trabecular bone and its relation to incident radiographic knee osteoarthritis and increase in joint space narrowing score: directional fractal signature analysis in the MOST study.
abstract: To explore the association of baseline trabecular bone structure with incident tibiofemoral (TF) osteoarthritis (OA) and with increase in joint space narrowing (JSN) score.
  
  
  
  The Multicenter Osteoarthritis Study (MOST) includes subjects with or at risk for knee OA. Knee radiographs were scored for Kellgren-Lawrence (KL) grade and JSN at baseline, 30, 60 and 84 months. Knees (KL ≤ 1) at baseline were assessed for incident OA (KL ≥ 2) and increases in JSN score. For each knee image at baseline, a variance orientation transform method (VOT) was applied to subchondral tibial bone regions of medial and lateral compartments. Seventeen fractal parameters were calculated per region. Associations of each parameter with OA incidence and with medial and lateral JSN increases were explored using logistic regression. Analyses were stratified by digitized film (DF) vs computer radiography (CR) and adjusted for confounders.
  
  
  
  Of 894 knees with CR and 1158 knees with DF, 195 (22%) and 303 (26%) developed incident OA. Higher medial bone roughness was associated with increased odds of OA incidence at 60 and 84 months and also, medial and lateral JSN increases (primarily vertical). Lower medial and lateral anisotropy was associated with increased odds of medial and lateral JSN increase. Compared to DF, CR had more associations and also, similar results at overlapping scales.
  
  
  
  Baseline trabecular bone texture was associated with incident radiographic OA and increase of JSN scores independently of risk factors for knee OA. Higher roughness and lower anisotropy were associated with increased odds for radiographic OA change.
authors.affiliation: Curtin University, Bentley, Australia. Electronic address: pawel.podsiadlo@curtin.edu.au.
authors.forename: P
authors.initials: P
authors.lastname: Podsiadlo
authors.affiliation: University of California San Francisco, San Francisco, CA, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Nevitt
authors.affiliation: Curtin University, Bentley, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Wolski
authors.affiliation: Curtin University, Bentley, Australia.
authors.forename: G W
authors.initials: GW
authors.lastname: Stachowiak
authors.affiliation: University of California San Francisco, San Francisco, CA, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Lynch
authors.affiliation: University of California San Francisco, San Francisco, CA, USA.
authors.forename: I
authors.initials: I
authors.lastname: Tolstykh
authors.affiliation: Boston University School of Medicine, Boston, MA, USA.
authors.forename: D T
authors.initials: DT
authors.lastname: Felson
authors.affiliation: University of Iowa, Iowa City, IA, USA.
authors.forename: N A
authors.initials: NA
authors.lastname: Segal
authors.affiliation: University of Alabama, Birmingham, AL, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Lewis
authors.affiliation: Boston University School of Medicine, Boston, MA, USA; Clinical Sciences Lund, Lund University, Lund, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Englund
mesh_terms: D000071556:Cancellous Bone; D018450:Disease Progression; D017709:Fractals; D006801:Humans; D007719:Knee Joint; D020370:Osteoarthritis, Knee; D011859:Radiography
keywords: Fractal; Joint space narrowing; Radiographic osteoarthritis; Radiography; Trabecular bone