title: What's LPS Got to Do with It? A Role for Gut LPS Variants in Driving Autoimmune and Allergic Disease.
abstract: The bacterial communities that live in and on our bodies have a profound influence on our health. In a new paper in Cell, Vatanen et al. (2016) report that the composition of the early-life gut microbiome, particularly those species producing lipopolysaccharide, influences the onset of autoimmune and allergic disease.
authors.affiliation: Department of Pathology and Committee on Immunology, The University of Chicago, 924 East 57th Street, R120, Chicago, IL 60637, USA.
authors.forename: Taylor
authors.initials: T
authors.lastname: Feehley
authors.affiliation: Department of Pathology and Committee on Immunology, The University of Chicago, 924 East 57th Street, R120, Chicago, IL 60637, USA.
authors.forename: Pedro
authors.initials: P
authors.lastname: Belda-Ferre
authors.affiliation: Department of Pathology and Committee on Immunology, The University of Chicago, 924 East 57th Street, R120, Chicago, IL 60637, USA. Electronic address: cnagler@bsd.uchicago.edu.
authors.forename: Cathryn R
authors.initials: CR
authors.lastname: Nagler
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology*; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D004731:Endotoxins / Q000276:immunology; D000069196:Gastrointestinal Microbiome / Q000276:immunology*; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000382:microbiology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007113:Immunity, Innate; D008070:Lipopolysaccharides / Q000276:immunology*
chemical_list: D004731:Endotoxins; D008070:Lipopolysaccharides; C044101:endotoxin, Escherichia coli