title: Oral Sildenafil for Severe Pulmonary Hypertension Developing after Ibuprofen Use in a Neonate.
abstract: BACKGROUND
  Severe pulmonary hypertension may following ibuprofen administration for ductal closure.
  
  
  METHODS
  An extremely preterm infant who developed severe pulmonary hypertension unresponsive to inhaled nitric oxide after ibuprofen administration.
  
  
  RESULTS
  Pulmonary hypertension reversed after the administration of oral sildenafil, but the infant died due to complications related to bronchopulmonary dysplasia.
  
  
  CONCLUSIONS
  Sildenafil may have a role in treatment of severe pulmonary hypertension after ibuprofen treatment for ductal closure.
authors.affiliation: Department of Neonatology, Hospital Clinico San Carlos, Madrid, Spain. Correspondence to: Dr M Jose Rodriguez-Castano, Department of Neonatology Hospital Clinico San Carlos, Profesor Martin Lagos s/n, 28040, Madrid, Spain. mariyou100@hotmail.com.
authors.forename: M Jose
authors.initials: MJ
authors.lastname: Rodriguez-Castano
authors.forename: Esther
authors.initials: E
authors.lastname: Aleo
authors.forename: Luis
authors.initials: L
authors.lastname: Arruza
mesh_terms: D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000188:drug therapy*; D007052:Ibuprofen / Q000009:adverse effects*; D007231:Infant, Newborn; D008297:Male; D000068677:Sildenafil Citrate / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D000068677:Sildenafil Citrate; D007052:Ibuprofen