title: Preoperative predictors for outcomes after total hip replacement in patients with osteoarthritis: a systematic review.
abstract: This systematic review examines which patient related factors influence functional and clinical outcomes after total hip arthroplasty (THA) in patients with hip osteoarthritis (OA).
  
  
  
  We performed a systematic review according to the PRISMA guidelines. We searched databases and trial registries for prospective studies including OA patients who underwent primary THA. Studies with preoperative measurements on predictors, with at least 1 year follow-up were included. Risk of bias and confounding was assessed for two domains: follow-up rate and looking at independent effects.
  
  
  
  Thirty-five studies were included (138,039 patients). Only nine studies (29 %) had low risk of bias for all domains thus suggesting an overall low quality of evidence. Studies were heterogeneous in the predictors tested and in the observed directions of the associations. Overall, preoperative function (13 studies (37 %), 2 with low risk of bias) and radiological OA (6 studies (17 %), 1 with low risk of bias) were predictors with the most consistent findings. Worse preoperative function and more severe radiological OA were associated with larger postoperative improvement. However, these patients never reached the level of postoperative functioning as patients with better preoperative function or less severe radiological OA. For age, gender, comorbidity, pain and quality of life the results of studies were conflicting. For BMI, some studies (n = 5, 2 with low risk of bias) found worse outcomes for patients with higher BMI. However, substantial improvement was still achieved regardless of their BMI.
  
  
  
  There is not enough evidence to draw succinct conclusions on preoperative predictors for postoperative outcome in THA, as results of studies are conflicting and the methodological quality is low. Results suggest to focus on preoperative function and radiological osteoarthritis to decide when THA will be most effective. The present mapping of current evidence on the relationship between patient related factors and outcomes provides better information compared to individual studies and may help to set patient expectations before surgery. In addition, these findings may contribute to discussions on how to achieve the best possible postoperative outcome for specific patient groups.
  
  
  
  This systematic review was registered in Prospero, registration number RD42014009977 .
authors.affiliation: Department of Orthopaedics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands.
authors.forename: Stefanie N
authors.initials: SN
authors.lastname: Hofstede
authors.affiliation: Department of Orthopaedics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands.|Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands.
authors.forename: Maaike G J
authors.initials: MG
authors.lastname: Gademan
authors.affiliation: Department of Orthopaedics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands.
authors.forename: Thea P M
authors.initials: TP
authors.lastname: Vliet Vlieland
authors.affiliation: Department of Orthopaedics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands.
authors.forename: Rob G H H
authors.initials: RG
authors.lastname: Nelissen
authors.affiliation: Department of Medical Decision Making, J10-S, Leiden University Medical Center, P.O. Box 9600, Leiden, 2300 RC, The Netherlands. p.j.marang@lumc.nl.
authors.forename: Perla J
authors.initials: PJ
authors.lastname: Marang-van de Mheen
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D015207:Osteoarthritis, Hip / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D010146:Pain / Q000453:epidemiology* / Q000209:etiology; D011184:Postoperative Period; D057234:Preoperative Period; D011788:Quality of Life; D011859:Radiography; D012737:Sex Factors; D016896:Treatment Outcome
keywords: Hip arthroplasty; Osteoarthritis; Outcome; Predictors; Review