title: Third trimester abnormal oral glucose tolerance test and adverse perinatal outcome.
abstract: OBJECTIVE
  To compare perinatal outcome of women after third trimester oral glucose tolerance test (GTT) following normal glucose challenge test (GCT) stratified by test results.
  
  
  METHODS
  Retrospective cohort study of women delivered in a tertiary, university affiliated medical center (2007-2012). Inclusion criteria were women with a normal 50 g GCT (<140 mg/dl) followed by GTT, who delivered a live-born fetus >28 gestational weeks. Gestational diabetes mellitus (GDM) was defined as ≥2 pathological values on GTT (Carpenter and Coustan's criteria). Perinatal outcome was stratified by GTT results: normal (if all 4 values were normal), single pathological value or GDM. Logistic regression analysis was utilized to adjust outcomes to potential confounders.
  
  
  RESULTS
  Overall, 323 women met inclusion criteria. Of them, 277 (85.8%) had 4 normal values, 32 (9.9%) had a single pathological value and 14 (4.3%) had late-onset GDM. Infants of mothers diagnosed and treated as GDM had lower birth weights, compared to non-diabetics and those with a single pathological value GTT. Mothers with GTT ≥1 pathological values had statistically insignificant higher rates of cesarean delivery. However, this difference was not significant after adjustment to potential confounders.
  
  
  CONCLUSIONS
  Treatment of late-onset GDM may lead to lower birthweights, presumably due to glucose control. No association was found with cesarean delivery or neonatal outcome.
authors.affiliation: a Helen Schneider Hospital for Women, Rabin Medical Center , Petach-Tikva , Israel , and.|b The Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
authors.forename: Nissim
authors.initials: N
authors.lastname: Arbib
authors.affiliation: a Helen Schneider Hospital for Women, Rabin Medical Center , Petach-Tikva , Israel , and.|b The Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
authors.forename: Rinat
authors.initials: R
authors.lastname: Gabbay-Benziv
authors.affiliation: a Helen Schneider Hospital for Women, Rabin Medical Center , Petach-Tikva , Israel , and.|b The Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
authors.forename: Amir
authors.initials: A
authors.lastname: Aviram
authors.affiliation: a Helen Schneider Hospital for Women, Rabin Medical Center , Petach-Tikva , Israel , and.|b The Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
authors.forename: Orly
authors.initials: O
authors.lastname: Sneh-Arbib
authors.affiliation: a Helen Schneider Hospital for Women, Rabin Medical Center , Petach-Tikva , Israel , and.|b The Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
authors.forename: Arnon
authors.initials: A
authors.lastname: Wiznitzer
authors.affiliation: a Helen Schneider Hospital for Women, Rabin Medical Center , Petach-Tikva , Israel , and.|b The Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
authors.forename: Moshe
authors.initials: M
authors.lastname: Hod
authors.affiliation: a Helen Schneider Hospital for Women, Rabin Medical Center , Petach-Tikva , Israel , and.|b The Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
authors.forename: Rony
authors.initials: R
authors.lastname: Chen
authors.affiliation: a Helen Schneider Hospital for Women, Rabin Medical Center , Petach-Tikva , Israel , and.|b The Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
authors.forename: Eran
authors.initials: E
authors.lastname: Hadar
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011263:Pregnancy Trimester, Third / Q000097:blood*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D001786:Blood Glucose
keywords: GDM screening; oral glucose tolerance test; perinatal outcome