title: Scedosporium apiospermum infections and the role of combination antifungal therapy and GM-CSF: A case report and review of the literature.
abstract: Scedosporium apiospermum, a ubiquitous environmental mold, is increasingly reported as causing invasive fungal disease in immunocompromised hosts. It poses a therapeutic challenge due to its intrinsic resistance to traditional antifungals and ability to recur despite demonstrating susceptibility. We present an immunocompromised patient with a cutaneous S. apiospermum infection that disseminated despite treatment with voriconazole, the drug of choice. Adding echinocandins and GM-CSF provided partial recovery, indicating a potential synergistic role of dual-antifungal and immunotherapeutic agents.
authors.affiliation: New York University Medical Center, 550 First Avenue, New York, NY 10016, USA.
authors.forename: Chloe
authors.initials: C
authors.lastname: Goldman
authors.affiliation: New York University Medical Center, 550 First Avenue, New York, NY 10016, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Akiyama
authors.affiliation: New York University Medical Center, 550 First Avenue, New York, NY 10016, USA.
authors.forename: Julian
authors.initials: J
authors.lastname: Torres
authors.affiliation: New York University Medical Center, 550 First Avenue, New York, NY 10016, USA.
authors.forename: Eddie
authors.initials: E
authors.lastname: Louie
authors.affiliation: New York University Medical Center, 550 First Avenue, New York, NY 10016, USA.
authors.forename: Shane A
authors.initials: SA
authors.lastname: Meehan
keywords: Corticosteroid; GM-CSF; Immunocompromised; Scedosporium; Synergy