title: Effects of Human Erythropoietin on Functional Outcome of Patients with Traumatic Cervical Cord Injury; A Pilot Randomized Clinical Trial.
abstract: OBJECTIVE
  To determine the effects of recombinant human erythropoietin (rhEPO) on functional outcome and disability of patients with traumatic cervical spinal cord injury (SCI).
  
  
  METHODS
  This was a randomized, double blind, placebo controlled clinical trial being performed in Nemazee and Shahid Rajaei hospitals of Shiraz during a 3-year period from 2011 to 2014. A total number of 20 patients with acute traumatic cervical SCI less than 8 hours after injury were included. We excluded those with anatomic cord dissection, penetrating cord injury and significant concomitant injury. Patients were randomly assigned to receive rhEPO in 500IU/mL dosage immediately and 24-hour later (n=11) or placebo (n=9). All the patient received standard regimen of methylprednisolone. Neurological function was assessed on admission, 1, 6 and 12 months after the injury according to the American Spinal Cord Injury Association (ASIA).
  
  
  RESULTS
  Overall we include a total number of 20 patients. The mean age of the patients was found to be 40.1±9.5 (ranging from 19 to 59) years. There were 18 (90.0%) men and 2 (10.0%) women among the patients. There was no significant difference between two study groups regarding the baseline characteristics. The baseline ASIA score was comparable between two study groups. The motor and sensory ASIA scores were comparable between two study groups after 1, 6 and 12 months follow-ups. We also found that there was no significant difference between two study groups regarding the motor and sensory outcome in complete cord injury and incomplete cord injury subgroups.
  
  
  CONCLUSIONS
  Administration of rhEPO does not improve the functional outcome of patients with traumatic cervical SCI.
authors.affiliation: Department of Neurosurgery, Shiraz University of Medical Science, Shiraz, Iran.
authors.forename: Ehsan Ali
authors.initials: EA
authors.lastname: Alibai
authors.affiliation: Department of Neurosurgery, Shiraz University of Medical Science, Shiraz, Iran.
authors.forename: Fahim
authors.initials: F
authors.lastname: Baghban
authors.affiliation: Department of Neurosurgery, Shiraz University of Medical Science, Shiraz, Iran.
authors.forename: Majid Reza
authors.initials: MR
authors.lastname: Farrokhi
authors.affiliation: Department of Neurosurgery, Shiraz University of Medical Science, Shiraz, Iran.
authors.forename: Navideh
authors.initials: N
authors.lastname: Mohebali
authors.affiliation: Department of Neurosurgery, Shiraz University of Medical Science, Shiraz, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Ashraf
keywords: Cervical cord injury; Disability; Erythropoietin; Functional outcome; Neuroprotective effect