title: Comparison between 18F-FDG PET/MRI and MDCT for the assessment of preoperative staging and resectability of gastric cancer.
abstract: OBJECTIVE
  To investigate if 18F-FDG PET/MRI can improve the diagnostic performance of TNM staging and help make an accurate decision for resectability in patients with gastric cancer compared to MDCT.
  
  
  METHODS
  Forty-two patients with histologically confirmed gastric cancers underwent preoperative MDCT and 18F-FDG PET/MRI. M-staging and resectability was assessed in all patients, and T- and N-staging was evaluated in 30 of 42 patients who underwent curative gastrectomy. Two abdominal radiologists independently assessed their MDCT images and 18F-FDG PET/MRI and determined preoperative TNM staging and resectability of gastric cancers. Diagnostic performance with MDCT and 18F-FDG PET/MRI were compared using McNemar's test and receiver operating characteristic analysis.
  
  
  RESULTS
  Diagnostic accuracies for T and N staging were not significantly different between MDCT and 18F-FDG PET/MRI in both readers. However, 18F-FDG PET/MRI showed significantly improved diagnostic accuracy for M staging in one reader (P=0.008) and marginal improvement in the other reader (P=0.063) compared to MDCT. Regarding the resectability of gastric cancers, diagnostic accuracy (92.9% for both readers) of 18F-FDG PET/MRI was significantly higher than that (76.2% for reader 1 and 64.3% for reader 2) of MDCT in both readers (P<0.05).
  
  
  CONCLUSIONS
  18F-FDG PET/MRI may improve diagnostic accuracy for preoperative M staging as well as resectability of gastric cancers compared to MDCT.
authors.affiliation: Department of Radiology, Seoul National University Hospital, South Korea; Department of Radiology, Seoul National University College of Medicine, South Korea.
authors.forename: Dong Ho
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Radiology, Seoul National University Hospital, South Korea; Department of Radiology, Seoul National University College of Medicine, South Korea. Electronic address: shkim7071@gmail.com.
authors.forename: Se Hyung
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Radiology, Seoul National University Hospital, South Korea; Department of Radiology, Seoul National University College of Medicine, South Korea.
authors.forename: Ijin
authors.initials: I
authors.lastname: Joo
authors.affiliation: Department of Radiology, National Cancer Center, South Korea.
authors.forename: Bo Yun
authors.initials: BY
authors.lastname: Hur
authors.affiliation: Department of Radiology, Seoul National University Hospital, South Korea; Department of Radiology, Seoul National University College of Medicine, South Korea; Institute of Radiation Medicine, Seoul National University Medical Research Center, South Korea.
authors.forename: Joon Koo
authors.initials: JK
authors.lastname: Han
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D000068598:Data Accuracy; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000379:methods; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008207:Lymphatic Metastasis / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods* / Q000706:statistics & numerical data; D064847:Multimodal Imaging / Q000379:methods* / Q000706:statistics & numerical data; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods* / Q000706:statistics & numerical data; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: 18F-FDG PET/MRI; Gastric cancer; MDCT; Resectability; Staging