title: Human Placental Histopathology in Preterm Stillbirth: One Center's Experience.
abstract: Our aim is to identify maternal risk factors and to determine placental histopathologies in preterm stillbirths. We designed a prospective study involving a patient population (n = 136) composed of singleton stillbirth (n = 40) and singleton live-born neonates (n = 96) between 23 0/7 and 36 6/7 weeks of gestation. We divided the stillbirths into groups of early (n = 21) and late (n = 19) stillbirths. Statistical analyses were performed using SPSS version 15 software. Small birth weight for gestational age and oligo-anhydramnios were significantly higher in the early stillbirth group (p = 0.001, p = 0.002 respectively). Antenatal follow up was significantly lower in the late stillbirth group (p = 0.001). Placental weight was statistically lower in the early stillbirth group (p = 0.001). We found no significant differences in maternal vascular underperfusion, fetal vascular obstruction, inflammation and villitis of unknown etiology. Placental pathologies causing preterm labor may play an important role in the etiology of stillbirths and antenatal follow up is essential for each pregnancy.
authors.affiliation: a Department of Pediatrics , Bakirkoy Dr Sadi Konuk Teaching and Research Hospital, Neonatal Intensive Care Unit , Istanbul , Turkey.
authors.forename: Özgül
authors.initials: Ö
authors.lastname: Salihoğlu
authors.affiliation: b Department of Obstetrics and Gynecology , Bakirkoy Dr Sadi Konuk Teaching and Research Hospital , Istanbul , Turkey.
authors.forename: Keziban
authors.initials: K
authors.lastname: Doğan
authors.affiliation: c Department of Pathology , Bakirkoy Dr Sadi Konuk Teaching and Research Hospital , Istanbul , Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Sever
authors.affiliation: a Department of Pediatrics , Bakirkoy Dr Sadi Konuk Teaching and Research Hospital, Neonatal Intensive Care Unit , Istanbul , Turkey.
authors.forename: Sinem Can
authors.initials: SC
authors.lastname: Oksay
authors.affiliation: b Department of Obstetrics and Gynecology , Bakirkoy Dr Sadi Konuk Teaching and Research Hospital , Istanbul , Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Yaşar
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010920:Placenta / Q000473:pathology*; D010922:Placenta Diseases / Q000453:epidemiology / Q000473:pathology; D011247:Pregnancy; D047928:Premature Birth / Q000209:etiology / Q000473:pathology*; D011446:Prospective Studies; D012307:Risk Factors; D050497:Stillbirth
keywords: histopathology; placenta; stillbirth