title: MoRFchibi SYSTEM: software tools for the identification of MoRFs in protein sequences.
abstract: Molecular recognition features, MoRFs, are short segments within longer disordered protein regions that bind to globular protein domains in a process known as disorder-to-order transition. MoRFs have been found to play a significant role in signaling and regulatory processes in cells. High-confidence computational identification of MoRFs remains an important challenge. In this work, we introduce MoRFchibi SYSTEM that contains three MoRF predictors: MoRFCHiBi, a basic predictor best suited as a component in other applications, MoRFCHiBi_ Light, ideal for high-throughput predictions and MoRFCHiBi_ Web, slower than the other two but best for high accuracy predictions. Results show that MoRFchibi SYSTEM provides more than double the precision of other predictors. MoRFchibi SYSTEM is available in three different forms: as HTML web server, RESTful web server and downloadable software at: http://www.chibi.ubc.ca/faculty/joerg-gsponer/gsponer-lab/software/morf_chibi/.
authors.affiliation: Michael Smith Laboratories-Centre for High-Throughput Biology, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada nmalhis@chibi.ubc.ca.
authors.forename: Nawar
authors.initials: N
authors.lastname: Malhis
authors.affiliation: Michael Smith Laboratories-Centre for High-Throughput Biology, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
authors.forename: Matthew
authors.initials: M
authors.lastname: Jacobson
authors.affiliation: Michael Smith Laboratories-Centre for High-Throughput Biology, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada gsponer@chibi.ubc.ca.
authors.forename: Jörg
authors.initials: J
authors.lastname: Gsponer
mesh_terms: D000595:Amino Acid Sequence; D019985:Benchmarking; D017252:CD3 Complex / Q000737:chemistry / Q000378:metabolism; D066264:Datasets as Topic; D057166:High-Throughput Screening Assays; D006801:Humans; D020407:Internet; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D012984:Software
chemical_list: D017252:CD3 Complex; C115335:CD3E protein, human; D011506:Proteins