title: A Lasting Impression: Epigenetic Memory of Bacterial Infections?
abstract: Bacteria can reprogram host gene expression during infection, often through epigenomic mechanisms. However, the lasting impact of such effects remains understudied. This forum discusses examples suggesting that bacterial infection can result in long-lasting memory encoded in epigenomic mechanisms and speculates on the potential of others.
authors.affiliation: Institut Pasteur, Unité des interactions Bactéries-Cellules, Paris 75015, France; INSERM, U604, Paris 75015, France; INRA, USC 2020, Paris 75015, France; Institut Pasteur, G5 Chromatine et Infection, Paris 75015, France.
authors.forename: Jorge M
authors.initials: JM
authors.lastname: Pereira
authors.affiliation: Institut Pasteur, G5 Chromatine et Infection, Paris 75015, France. Electronic address: melanie.hamon@pasteur.fr.
authors.forename: Mélanie A
authors.initials: MA
authors.lastname: Hamon
authors.affiliation: Institut Pasteur, Unité des interactions Bactéries-Cellules, Paris 75015, France; INSERM, U604, Paris 75015, France; INRA, USC 2020, Paris 75015, France. Electronic address: pcossart@pasteur.fr.
authors.forename: Pascale
authors.initials: P
authors.lastname: Cossart
mesh_terms: D001419:Bacteria / Q000235:genetics* / Q000378:metabolism; D001424:Bacterial Infections / Q000235:genetics* / Q000382:microbiology; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006790:Host-Parasite Interactions / Q000235:genetics*; D006801:Humans; D015533:Transcriptional Activation