title: Clinical Question: In adults with COPD does roflumilast reduce the frequency of exacerbations compDared to standard therapies aIone?
authors.forename: John Marshall
authors.initials: JM
authors.lastname: Huser
authors.forename: Jeffrey Dean
authors.initials: JD
authors.lastname: Hodgden
mesh_terms: D000328:Adult; D000631:Aminopyridines / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D003521:Cyclopropanes / Q000627:therapeutic use; D018450:Disease Progression; D006801:Humans; D062072:Patient Acuity; D058988:Phosphodiesterase 4 Inhibitors / Q000627:therapeutic use; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D012129:Respiratory Function Tests
chemical_list: D000631:Aminopyridines; D001549:Benzamides; D003521:Cyclopropanes; D058988:Phosphodiesterase 4 Inhibitors; C424423:Roflumilast