title: [The clinical aspects of HPV-positive cancer of the oral cavity and oropharynx].
abstract: This review was designed to focus on the prevalence and the magnitude of infection with human papilloma virus (HPV) among healthy subjects and patients presenting with cancer of the oral cavity and oropharynx. We compare the data on the relative frequency of HPV-positive and HPV-negative cancer of the oral cavity and oropharynx in different populations, peculiarities of the clinical course of this pathology, and methods of its treatment. Much emphasis is placed on the specific clinical and morphological features of HPV-positive cancer of the oral cavity and oropharynx. The general and relapse-free survival rates are considered with special reference to the outcome and prognosis of this disease. The currently accepted approaches to the treatment of HPV-positive cancer of the oral cavity and oropharynx are discussed. It is concluded that HPV-positive cancer of the oral cavity and oropharynx should be regarded as an autonomous pathological condition requiring specific approaches to its management, such as the application of adequate treatment schemes and algorithms.
authors.affiliation: Tomsk Research Institute of Oncology, Tomsk, Russia, 634050.
authors.forename: O Yu
authors.initials: OY
authors.lastname: Dvoryaninova
authors.affiliation: Tomsk Research Institute of Oncology, Tomsk, Russia, 634050.
authors.forename: E L
authors.initials: EL
authors.lastname: Chainzonov
authors.affiliation: Tomsk Research Institute of Oncology, Tomsk, Russia, 634050; Tomsk National Research University, Tomsk, Russia, 634050.
authors.forename: N V
authors.initials: NV
authors.lastname: Litvyakov
mesh_terms: D015897:Comorbidity; D006801:Humans; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D027383:Papillomaviridae / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000628:therapy