title: GENOME-WIDE MAPPING OF COPY NUMBER VARIATIONS IN COMMERCIAL HYBRID PIGS USING A HIGH-DENSITY SNP GENOTYPING ARRAY.
abstract: Copy number variations (CNVs) are important forms of structural variation in human and animals and can be considered as a major genetic component of phenotypic diversity. Here we used the Illumina PorcineSNP60 BeadChip V2 and a DLY [Duroc x (Large White x Landrace)] commercial hybrid population to identify 272 CNVs belonging to 165 CNV regions (CNVRs), of which 66 are new. As CNVRs are specific to origin of population, our DLY-specific data is an important complementary to the existing CNV map in the pig genome. Eight CNVRs were selected. for validation by quantitative real-time PCR (qRT-PCR) and the accurate rate was high (87.25%). Gene function analysis suggested that a common CNVR may play an important role in multiple traits, including growth rate and carcass quality.
authors.forename: L S
authors.initials: LS
authors.lastname: Zhou
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: C L
authors.initials: CL
authors.lastname: Liu
authors.forename: X H
authors.initials: XH
authors.lastname: Xie
authors.forename: Y N
authors.initials: YN
authors.lastname: He
authors.forename: X X
authors.initials: XX
authors.lastname: Liu
authors.forename: W S
authors.initials: WS
authors.lastname: Xin
authors.forename: W C
authors.initials: WC
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Ren
authors.forename: J W
authors.initials: JW
authors.lastname: Ma
authors.forename: L S
authors.initials: LS
authors.lastname: Huang
mesh_terms: D000818:Animals; D001947:Breeding; D002874:Chromosome Mapping; D056915:DNA Copy Number Variations / Q000235:genetics*; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D006824:Hybridization, Genetic; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D034421:Sus scrofa / Q000235:genetics*