title: Photo-induced green synthesis and antimicrobial efficacy of poly (ɛ-caprolactone)/curcumin/grape leaf extract-silver hybrid nanoparticles.
abstract: This study reports the photo-induced green synthesis and antimicrobial assessment of poly(ɛ-caprolactone)/curcumin/grape leaf extract-Ag hybrid nanoparticles (PCL/Cur/GLE-Ag NPs). PCL/Cur/GLE NPs were synthesized via emulsion-solvent evaporation in the presence of PVA as a capping agent, then used as active nano-supports for the green synthesis and stabilization of AgNPs on their surfaces. Both Cur and GLE were selected and incorporated into the PCL nano-supports due to their reported promising antimicrobial activity that would further enhance that of the synthesized AgNPs. The developed PCL/Cur/GLE NPs and PCL/Cur/GLE-Ag hybrid NPs were characterized using UV-visible spectrophotometry, high resolution transmission electron microscopy (HRTEM) and X-ray diffraction (XRD). HRTEM images showed that the PCL/Cur/GLE NPs are monodispersed and spherical with size of about 270nm, and the AgNPs were formed mainly on their surfaces with average size in the range 10-30nm. The synthesized AgNPs were found to be crystalline as shown by XRD patterns with fcc phase oriented along the (111), (200), (220) and (311) planes. The antimicrobial characteristics of the newly developed NPs were investigated against gram-positive and gram-negative bacteria in addition to two fungal strains. The results demonstrated that the PCL/Cur/GLE-Ag hybrid NPs have a potential antimicrobial activity against pathogenic bacterial species and could be considered as an alternative antibacterial agent.
authors.affiliation: Center for Materials Science, Zewail City of Science and Technology, 6th October City, 12588, Giza, Egypt. Electronic address: ielsherbiny@zewailcity.edu.eg.
authors.forename: Ibrahim M
authors.initials: IM
authors.lastname: El-Sherbiny
authors.affiliation: Biomedical Science, Zewail City of Science and Technology, 6th October City, 12588, Giza, Egypt.
authors.forename: Ayman
authors.initials: A
authors.lastname: El-Shibiny
authors.affiliation: Center for Materials Science, Zewail City of Science and Technology, 6th October City, 12588, Giza, Egypt.
authors.forename: Ehab
authors.initials: E
authors.lastname: Salih
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003474:Curcumin / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D055772:Green Chemistry Technology; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D008826:Microbial Sensitivity Tests; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry / Q000378:metabolism; D011091:Polyesters / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D027843:Vitis / Q000737:chemistry / Q000378:metabolism; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts; D011091:Polyesters; C016240:polycaprolactone; D012834:Silver; D003474:Curcumin
keywords: Antimicrobial; Green synthesis; Hybrid nanoparticles; Photo-induced; Silver