title: Mechanical properties of natural chitosan/hydroxyapatite/magnetite nanocomposites for tissue engineering applications.
abstract: Chitosan (CS), hydroxyapatite (HA), and magnetite (Fe3O4) have been broadly employed for bone treatment applications. Having a hybrid biomaterial composed of the aforementioned constituents not only accumulates the useful characteristics of each component, but also provides outstanding composite properties. In the present research, mechanical properties of pure CS, CS/HA, CS/HA/magnetite, and CS/magnetite were evaluated by the measurements of bending strength, elastic modulus, compressive strength and hardness values. Moreover, the morphology of the bending fracture surfaces were characterized using a scanning electron microscope (SEM) and an image analyzer. Studies were also conducted to examine the biological response of the human Mesenchymal Stem Cells (hMSCs) on different composites. We conclude that, although all of these composites possess in-vitro biocompatibility, adding hydroxyapatite and magnetite to the chitosan matrix can noticeably enhance the mechanical properties of the pure chitosan.
authors.affiliation: Department of Materials Science and Engineering, School of Engineering, Yasouj University, Yasuj 75918-74934, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Heidari
authors.affiliation: BCAST, Institute of Materials and Manufacturing, Brunel University London, Uxbridge, London UB8 3PH, UK; Brunel Institute for Bioengineering, Brunel University London, Uxbridge, London UB8 3PH, UK.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Razavi
authors.affiliation: Department of Materials Science and Engineering, School of Engineering, Shiraz University, Shiraz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: E Bahrololoom
authors.affiliation: Department of Materials Science and Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Bazargan-Lari
authors.affiliation: Electrical and Computer Engineering Department, North Carolina State University, Raleigh, NC 27606, USA.
authors.forename: Daryoosh
authors.initials: D
authors.lastname: Vashaee
authors.affiliation: Department of Biology, University of Central Oklahoma, Edmond, OK 73034, USA.
authors.forename: Hari
authors.initials: H
authors.lastname: Kotturi
authors.affiliation: Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, WI 53233, USA; Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, UK. Electronic address: lobat.tayebi@marquette.edu.
authors.forename: Lobat
authors.initials: L
authors.lastname: Tayebi
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D019245:Compressive Strength; D017886:Durapatite / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry; D006244:Hardness; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D059630:Mesenchymal Stem Cells / Q000166:cytology; D008855:Microscopy, Electron, Scanning; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D058185:Magnetite Nanoparticles; D048271:Chitosan; D017886:Durapatite; D052203:Ferrosoferric Oxide
keywords: Bending; Chitosan; Compressive; Hardness; Hydroxyapatite; Magnetite nano-particles