title: Prucalopride: For functional constipation only?
abstract: Prucalopride is a new prokinetic agent, recently available in Europe for the treatment of functional constipation in adults in whom treatment with laxatives failed to provide adequate relief. However, due to its intrinsic properties (highly selective agonist activity and high affinity for 5-HT4 receptors, neuroprotection), this drug has shown the potential to be used in other pathologic conditions, in and outside of the gastrointestinal tract. We performed a systematic review of the evidence supporting these possible alternative uses of prucalopride. Further studies in this area are, however, mandatory.
authors.affiliation: Gastrointestinal Unit, Department of Gastroenterology, University of Pisa, Pisa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bellini
authors.affiliation: Gastrointestinal Unit, Department of Gastroenterology, University of Pisa, Pisa, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Gambaccini
authors.affiliation: Gastroenterology and Hepatology Section, Department of Medicine, University of Perugia Medical School, Piazza Lucio Severi, 1, 06132, San Sisto (Perugia), Italy. gabassot@tin.it.
authors.forename: G
authors.initials: G
authors.lastname: Bassotti
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects; D001572:Benzofurans / Q000627:therapeutic use*; D003108:Colonic Diseases / Q000188:drug therapy*; D003248:Constipation / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D045823:Ileus / Q000188:drug therapy; D007418:Intestinal Pseudo-Obstruction / Q000188:drug therapy*; D009103:Multiple Sclerosis / Q000150:complications; D058828:Serotonin 5-HT4 Receptor Agonists / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000150:complications
chemical_list: D000701:Analgesics, Opioid; D001572:Benzofurans; D058828:Serotonin 5-HT4 Receptor Agonists; C406662:prucalopride
keywords: Alternative uses; Constipation; Prucalopride; Treatment