title: Interferon γ and interleukin 10 responses in immunocompetent and immunosuppressed New Zealand White rabbits naturally infected with Encephalitozoon cuniculi.
abstract: Levels of interferon (IFN)-γ and interleukin (IL)-10 were measured in the serum of immunocompetent and immunosuppressed New Zealand White rabbits naturally infected with Encephalitozoon cuniculi. IFN-γ levels were elevated in infected rabbits, and a synergic effect was observed in animals treated with the immunosuppressive agent dexamethasone (Dex). The role of IL-10 in infected rabbits remains unclear, as IL-10 levels were similar to those of negative controls. Dex appeared to exhibit a proinflammatory effect, as IFN-γ levels were elevated in infected immunosuppressed rabbits. Similarly, Dex exhibited a synergic effect in infected immunosuppressed rabbits, as evidenced by the elevation in IFN-γ production. These data indicate that the immune response to this glucocorticoid should be considered in the design of future animal model studies of immunosuppression.
authors.affiliation: Cuerpo Académico de Zoonosis y Enfermedades Emergentes, Facultad de Medicina Veterinaria, UANL, General Escobedo, N. L., CP 66050, Mexico.
authors.forename: Luis E
authors.initials: LE
authors.lastname: Rodríguez-Tovar
authors.affiliation: Cuerpo Académico de Zoonosis y Enfermedades Emergentes, Facultad de Medicina Veterinaria, UANL, General Escobedo, N. L., CP 66050, Mexico. Electronic address: uziel_c@hotmail.com.
authors.forename: Uziel
authors.initials: U
authors.lastname: Castillo-Velázquez
authors.affiliation: Cuerpo Académico de Inmunología Clínica y Dermatología, Facultad de Medicina, UANL, Col. Mitras Centro, Monterrey, N. L., CP 64460, Mexico.
authors.forename: Alma Y
authors.initials: AY
authors.lastname: Arce-Mendoza
authors.affiliation: Cuerpo Académico de Zoonosis y Enfermedades Emergentes, Facultad de Medicina Veterinaria, UANL, General Escobedo, N. L., CP 66050, Mexico.
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Nevárez-Garza
authors.affiliation: Cuerpo Académico de Epidemiologia Veterinaria, Facultad de Medicina Veterinaria, UANL, General Escobedo, N. L., CP 66050, Mexico.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Zarate-Ramos
authors.affiliation: Cuerpo Académico de Patobiología, Facultad de Medicina Veterinaria, UANL, General Escobedo, N. L., CP 66050, Mexico.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Hernández-Vidal
authors.affiliation: Cuerpo Académico de Zoonosis y Enfermedades Emergentes, Facultad de Medicina Veterinaria, UANL, General Escobedo, N. L., CP 66050, Mexico.
authors.forename: Heidi G
authors.initials: HG
authors.lastname: Rodríguez-Ramírez
authors.affiliation: Cuerpo Académico de Zoonosis y Enfermedades Emergentes, Facultad de Medicina Veterinaria, UANL, General Escobedo, N. L., CP 66050, Mexico.
authors.forename: Armando
authors.initials: A
authors.lastname: Trejo-Chávez
mesh_terms: D000818:Animals; D003907:Dexamethasone / Q000008:administration & dosage*; D004195:Disease Models, Animal; D009670:Encephalitozoon cuniculi / Q000276:immunology*; D016890:Encephalitozoonosis / Q000276:immunology*; D007121:Immunocompetence; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D018836:Inflammation Mediators / Q000378:metabolism*; D007371:Interferon-gamma / Q000378:metabolism*; D016753:Interleukin-10 / Q000378:metabolism; D011817:Rabbits / Q000276:immunology*
chemical_list: D007166:Immunosuppressive Agents; D018836:Inflammation Mediators; D016753:Interleukin-10; D003907:Dexamethasone; D007371:Interferon-gamma
keywords: Encephalitozoon cuniculi; IFN-γ; IL-10; Immune response; Microsporidia; Rabbit