title: Cannabis for Refractory Psoriasis-High Hopes for a Novel Treatment and a Literature Review.
abstract: Psoriasis is a common skin disorder characterized by hyper proliferation of keratinocytes. Although the exact pathophysiology of psoriasis is not entirely understood, immune system and its interaction with nervous system have been postulated and investigated as the underlying mechanism. The interaction between these two systems through cholinergic anti-inflammatory pathway and also endocannabinoid system, may suggest cannabinoids as potential addition to antipsoriatic armamentarium.
authors.affiliation: Department of Neurosurgery, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. nima_med83@yahoo.com.
authors.forename: Nima
authors.initials: N
authors.lastname: Derakhshan
authors.forename: Mahboubeh
authors.initials: M
authors.lastname: Kazemi
mesh_terms: D002186:Cannabinoids / Q000008:administration & dosage* / Q000494:pharmacology; D049109:Cell Proliferation; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000494:pharmacology; D063388:Endocannabinoids / Q000378:metabolism*; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
chemical_list: D002186:Cannabinoids; D003879:Dermatologic Agents; D063388:Endocannabinoids