title: Biochemical Basis of Sestrin Physiological Activities.
abstract: Excessive accumulation of reactive oxygen species (ROS) and chronic activation of mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) are well-characterized promoters of aging and age-associated degenerative pathologies. Sestrins, a family of highly conserved stress-inducible proteins, are important negative regulators of both ROS and mTORC1 signaling pathways; however, the mechanistic basis of how Sestrins suppress these pathways remains elusive. In the past couple of years, breakthrough discoveries about Sestrin signaling and its molecular nature have markedly increased our biochemical understanding of Sestrin function. These discoveries have also uncovered new potential therapeutic strategies that may eventually enable us to attenuate aging and age-associated diseases.
authors.affiliation: Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Allison
authors.initials: A
authors.lastname: Ho
authors.affiliation: Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Chun-Seok
authors.initials: CS
authors.lastname: Cho
authors.affiliation: Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Sim
authors.initials: S
authors.lastname: Namkoong
authors.affiliation: Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Uhn-Soo
authors.initials: US
authors.lastname: Cho
authors.affiliation: Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: leeju@umich.edu.
authors.forename: Jun Hee
authors.initials: JH
authors.lastname: Lee
mesh_terms: D001669:Biochemical Phenomena; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism*; D000084622:Sestrins
chemical_list: D006360:Heat-Shock Proteins; D009687:Nuclear Proteins; C117338:SESN1 protein, human; D000084622:Sestrins; C465398:SESN2 protein, human; C485523:SESN3 protein, human
keywords: ROS; Sestrin; aging; leucine; mTOR; structure