title: (18)F-AV-133: A Selective VMAT2-binding Radiopharmaceutical for PET Imaging of Dopaminergic Neurons.
abstract: The early detection and monitoring of neurodegenerative diseases, including Parkinson disease, Alzheimer disease, dementia with Lewy bodies and other dementias, and movement disorders, represent a significant unmet medical need. Tools for accurate and early differential diagnosis are necessary to determine the appropriate treatment for patients and to minimize inappropriate use of potentially harmful treatments. Such diagnostic imaging tools are expected to permit monitoring of disease progression and will thus accelerate testing and development of disease-modifying drugs. The new imaging tests may be useful as prognostic tools by identifying humans with neurodegenerative diseases before the clinical manifestations become evident.
authors.affiliation: Avid Radiopharmaceuticals Inc, 3711 Market Street, 7th Floor, Philadelphia, PA 19104, USA.
authors.forename: Franz F
authors.initials: FF
authors.lastname: Hefti
authors.affiliation: Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Hank F
authors.initials: HF
authors.lastname: Kung
authors.affiliation: Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Kilbourn
authors.affiliation: Avid Radiopharmaceuticals Inc, 3711 Market Street, 7th Floor, Philadelphia, PA 19104, USA.
authors.forename: Alan P
authors.initials: AP
authors.lastname: Carpenter
authors.affiliation: Avid Radiopharmaceuticals Inc, 3711 Market Street, 7th Floor, Philadelphia, PA 19104, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Clark
authors.affiliation: Avid Radiopharmaceuticals Inc, 3711 Market Street, 7th Floor, Philadelphia, PA 19104, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: skrovronsky@avidrp.com.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Skovronsky
keywords: (18)F-AV-133; Dopaminergic neurons; Imaging agents; PET imaging