title: Association of matrix metalloproteinase 3 and γ-glutamyltransferase 1 gene polymorphisms with the cardio-ankle vascular index in young Russians.
abstract: Specific gene polymorphisms are known to be associated with a different arterial physiology in the younger generation. The present study found that young Russians with the matrix metalloproteinase 3 6A/6A and γ-glutamyltransferase 1AA genotypes have lower levels of the cardio-ankle vascular index - a recent measure of arterial stiffness. This observation may serve as an additional tool for cardiovascular disease prevention in the young population.
authors.affiliation: 1Department of Internal Medicine,Kursk State Medical University,Kursk,Russia.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Sorokin
authors.affiliation: 2Division of Community and Family Medicine,Jichi Medical University,Tochigi,Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.affiliation: 3Department of Biology, Medical Genetics and Ecology,Kursk State Medical University,Kursk,Russia.
authors.forename: Olga Y
authors.initials: OY
authors.lastname: Bushueva
mesh_terms: D002318:Cardiovascular Diseases / Q000517:prevention & control; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D011110:Polymorphism, Genetic; D012426:Russia; D059289:Vascular Stiffness / Q000235:genetics*; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000235:genetics*
chemical_list: D005723:gamma-Glutamyltransferase; C554782:gamma-glutamyltransferase, human; C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3
keywords: Arterial stiffness; cardio-ankle vascular index; matrix metalloproteinase; polymorphism; stromelysin-1; γ-glutamyltransferase