title: The Highly Evolvable Antibody Fc Domain.
abstract: The Fc region of the IgG antibody recruits immune leukocytes or serum complement molecules, which in turn triggers the clearance of defective cells such as tumor cells or infected cells. In addition, the Fc region is crucial for the prolonged serum persistence of circulating IgG antibodies through an intracellular trafficking and recycling mechanism. Recently, the utility of antibody Fc has been further expanded to include a new class of antigen-binding scaffolds. This review presents the recent progress in the field of antibody Fc engineering and highlights new biomolecular, cellular, and evolutionary approaches to overcome the limitations of conventional monoclonal therapeutic antibodies by engineering the antibody Fc domain.
authors.affiliation: Department of Bio and Nano Chemistry, Kookmin University, Seoul 136-702, Korea.
authors.forename: Hye In
authors.initials: HI
authors.lastname: Park
authors.affiliation: Department of Bio and Nano Chemistry, Kookmin University, Seoul 136-702, Korea.
authors.forename: Hyun Woung
authors.initials: HW
authors.lastname: Yoon
authors.affiliation: Department of Bio and Nano Chemistry, Kookmin University, Seoul 136-702, Korea. Electronic address: sjung@kookmin.ac.kr.
authors.forename: Sang Taek
authors.initials: ST
authors.lastname: Jung
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D051379:Mice; D015202:Protein Engineering; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D007141:Immunoglobulin Fc Fragments; D011994:Recombinant Proteins
keywords: antibody Fc; antibody engineering; effector functions; serum half-life