title: Hydrogels for brain repair after stroke: an emerging treatment option.
abstract: Stroke disability is the only major disease without an effective treatment. The substantial clinical burden of stroke in disabled survivors and the lack of a medical therapy that promotes recovery provide an opportunity to explore the use of biomaterials to promote brain repair after stroke. Hydrogels can be injected as a liquid and solidify in situ to form a gelatinous solid with similar mechanical properties to the brain. These biomaterials have been recently explored to generate pro-repair environments within the damaged organ. This review highlights the clinical problem of stroke treatment and discusses recent advances in using in situ forming hydrogels for brain repair.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, CA 90095, USA.
authors.forename: Lina Ratiba
authors.initials: LR
authors.lastname: Nih
authors.affiliation: Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 621 Charles Young Drive, CA 90095, USA.
authors.forename: Stanley Thomas
authors.initials: ST
authors.lastname: Carmichael
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, CA 90095, USA. Electronic address: tsegura@ucla.edu.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Segura
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001927:Brain Diseases / Q000209:etiology / Q000628:therapy*; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage* / Q000737:chemistry; D020521:Stroke / Q000150:complications*; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels