title: [Limb salvage or amputation after severe trauma to the lower extremities : Evidence from the LEAP Study].
abstract: Deciding between reconstruction and primary amputation after severe high-energy trauma to the lower extremities is difficult and consequential. The Lower Extremity Assessment Project (LEAP) prospectively included and investigated patients with severe, limb-threatening injuries below the femur, with third-grade open fractures, defined soft-tissue damage and amputation wounds. This paper aims to review the key results of the LEAP study, which were published in several parts, in due consideration of the newer relevant literature, and to deduce the consequences for clinical practice. The main results are as follows: No score is sufficiently reliable to predict the success of reconstruction. Loss of muscle seems to be more momentous than loss of bone. Any accompanying injuries that should be taken into account in the individual treatment concepts are crucial to the results, in addition to comorbidities and other individual patient-related factors, such as alcoholism, smoking, insurance, and social background. Psychological impairment is frequent after these injuries and should therefore be addressed regularly with regard to rehabilitation.
authors.affiliation: Unfallchirurgische Klinik, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland. Mueller.Christian@MH-Hannover.de.
authors.forename: C W
authors.initials: CW
authors.lastname: Müller
authors.affiliation: Unfallchirurgische Klinik, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Krettek
authors.affiliation: Unfallchirurgische Klinik, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Decker
authors.affiliation: Klinik für Orthopädie und Unfallchirurgie, Sana Klinikum Hameln-Pyrmont, Hameln, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Hankemeier
authors.affiliation: Unfallchirurgische Klinik, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
authors.forename: N
authors.initials: N
authors.lastname: Hawi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical / Q000523:psychology / Q000534:rehabilitation* / Q000706:statistics & numerical data*; D000066491:Clinical Decision-Making / Q000379:methods*; D015897:Comorbidity; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D015994:Incidence; D007869:Leg Injuries / Q000453:epidemiology* / Q000523:psychology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016879:Salvage Therapy / Q000523:psychology / Q000706:statistics & numerical data*; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: Decision making; Leg injuries; Outcome assessment; Postoperative complications