title: Rapid Eye Movement Sleep Abnormalities in Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).
abstract: Polysomnographic investigation of sleep architecture in children presenting with pediatric acute-onset neuropsychiatric syndrome (PANS).
  
  
  
  Fifteen consecutive subjects meeting criteria for PANS (mean age = 7.2 y; range 3-10 y) underwent single-night full polysomnography (PSG) read by a pediatric neurologist.
  
  
  
  Thirteen of 15 subjects (87%) had abnormalities detected with PSG. Twelve of 15 had evidence of rapid eye movement (REM) sleep motor disinhibition, as characterized by excessive movement, laughing, hand stereotypies, moaning, or the continuation of periodic limb movements during sleep (PLMS) into REM sleep.
  
  
  
  This study shows various forms of REM sleep motor disinhibition present in a population of children with PANS.
authors.affiliation: Department of Pediatrics and Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD.
authors.forename: Thomas
authors.initials: T
authors.lastname: Gaughan
authors.affiliation: Department of Pediatrics and Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD.
authors.forename: Ashura
authors.initials: A
authors.lastname: Buckley
authors.affiliation: Department of Pediatrics and Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Hommer
authors.affiliation: Department of Pediatrics and Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD.
authors.forename: Paul
authors.initials: P
authors.lastname: Grant
authors.affiliation: Pediatric Neuropsychiatry and Immunology Program, Massachusetts General Hospital, Harvard University School of Medicine, Boston, MA.
authors.forename: Kyle
authors.initials: K
authors.lastname: Williams
authors.affiliation: Child Study Center, Yale University School of Medicine, New Haven, CT.
authors.forename: James F
authors.initials: JF
authors.lastname: Leckman
authors.affiliation: Department of Pediatrics and Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Swedo
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000150:complications*; D017286:Polysomnography; D020187:REM Sleep Behavior Disorder / Q000150:complications*
keywords: PANS; REM sleep behavior disorder; obsessive compulsive disorder; polysomnography