title: An Overlap Syndrome involving systemic lupus erythematosus and autoimmune hepatitis in an adolescent girl.
abstract: Overlap of systemic lupus erythematosus and autoimmune hepatitis is a rare condition, occasionally described. Both autoimmune diseases can share common autoimmune features such as polyartralgia, hypergammaglobulinemia and positive antinuclear antibody, but they have been considered as two different entities. We report a 14 year old female patient with systemic lupus erythematosus who developed autoimmune hepatitis two years later. She had jaundice with no history of viral infections, drug intake, alcohol abuses or exposition to blood products. She was positive for antinuclear antibody, double stranded DNA antibody and LKM 1 antibody. Histological examination of the liver showed interface hepatitis with lymphoplasmacytic cell infiltration. The patient satisfied the international criteria for both systemic lupus erythematosus and Type 2 autoimmune hepatitis. Clinical symptoms and laboratory findings improved under treatment with steroids and mycophenolate mofetil.
  
  
  
  Autoimmune hepatitis may occur during the course of systemic lupus erythematosus and an early diagnosis is important for preventing advanced liver disease. Definitive diagnosis of autoimmune hepatitis requires confirmation by means of a liver biopsy.
authors.affiliation: Hospital de Niños Dr. Orlando Alassia, Santa Fe, Argentina. cristinabattagliotti@yahoo.com.ar.
authors.forename: Cristina
authors.initials: C
authors.lastname: Battagliotti
authors.affiliation: Hospital de Niños Dr. Orlando Alassia, Santa Fe, Argentina.
authors.forename: Daniela
authors.initials: D
authors.lastname: Rispolo Klubek
authors.affiliation: Hospital de Niños Dr. Orlando Alassia, Santa Fe, Argentina.
authors.forename: Mario
authors.initials: M
authors.lastname: Karakachoff
authors.affiliation: Hospital de Niños Dr. Orlando Alassia, Santa Fe, Argentina.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Costaguta
mesh_terms: D000293:Adolescent; D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis*; D000074079:Undifferentiated Connective Tissue Diseases / Q000150:complications / Q000175:diagnosis*
keywords: Autoimmune hepatitis; Connective tissue diseases; Systemic lupus erythematosus