title: Association of growth and nutritional parameters with pulmonary function in cystic fibrosis: a literature review.
abstract: OBJECTIVE
  To review the literature addressing the relationship of growth and nutritional parameters with pulmonary function in pediatric patients with cystic fibrosis.
  
  
  METHODS
  A collection of articles published in the last 15 years in English, Portuguese and Spanish was made by research in electronic databases - PubMed, Cochrane, Medline, Lilacs and Scielo - using the keywords cystic fibrosis, growth, nutrition, pulmonary function in varied combinations. Articles that addressed the long term association of growth and nutritional parameters, with an emphasis on growth, with pulmonary disease in cystic fibrosis, were included, and we excluded those that addressing only the relationship between nutritional parameters and cystic fibrosis and those in which the aim was to describe the disease.
  
  
  RESULTS
  Seven studies were included, with a total of 12,455 patients. Six studies reported relationship between growth parameters and lung function, including one study addressing the association of growth parameters, solely, with lung function, and all the seven studies reported relationship between nutritional parameters and lung function.
  
  
  CONCLUSIONS
  The review suggests that the severity of the lung disease, determined by spirometry, is associated with body growth and nutritional status in cystic fibrosis. Thus, the intervention in these parameters can lead to the better prognosis and life expectancy for cystic fibrosis patients.
authors.affiliation: Faculdade de Ciências Médicas, Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil. Electronic address: renanmauch@gmail.com.
authors.forename: Renan Marrichi
authors.initials: RM
authors.lastname: Mauch
authors.affiliation: Faculdade de Ciências Médicas, Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.
authors.forename: Arthur Henrique Pezzo
authors.initials: AH
authors.lastname: Kmit
authors.affiliation: Faculdade de Ciências Médicas, Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.
authors.forename: Fernando Augusto de Lima
authors.initials: FA
authors.lastname: Marson
authors.affiliation: Faculdade de Ciências Médicas, Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.
authors.forename: Carlos Emilio
authors.initials: CE
authors.lastname: Levy
authors.affiliation: Faculdade de Ciências Médicas, Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.
authors.forename: Antonio de Azevedo
authors.initials: AA
authors.lastname: Barros-Filho
authors.affiliation: Faculdade de Ciências Médicas, Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.
authors.forename: José Dirceu
authors.initials: JD
authors.lastname: Ribeiro
mesh_terms: D002648:Child; D003550:Cystic Fibrosis / Q000503:physiopathology*; D006128:Growth; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D009752:Nutritional Status
keywords: Crescimento; Cystic fibrosis; Fibrose cística; Growth; Lung/pathophysiology; Nutrition; Nutrição; Pulmão/fisiopatologia