title: [Effects of an obesogenic diet enriched in sardine by-products on pro-atherogenic markers in Wistar rats].
abstract: OBJECTIVE
  The effects of an obesogenic diet enriched in sardine by-products (Sardina pilchardus) on blood pressure, glycemic control and some cardiovascular risk factors, in particular pro-atherogenic were studied on an experimental model.
  
  
  METHODS
  Male rats (n=12) weighing 200±10g were subjected to an adjustment phase of 10 days in an obesogenic diet containing 30% sheep fat. After this period, the rats were divided into two homogeneous groups. The first group (HF-SBp) consumes the obesogenic diet supplemented with 30% of by-products flour (F-SBp), and the second (HF) continuous to consume the obesogenic diet and serve as control.
  
  
  RESULTS
  At day 30, in HF-SBp versus HF group: a reduction was noted in diastolic (-11%) and systolic (-10%) pressure, glycemia (-19%), glycated hemoglobin percent (-43%), serum total lipids concentration (-22%), triacylglycerols (-37%), total cholesterol (-29%) and unesterified cholesterol (-30%), cholesteryl esters (-30%), cholesterol of very low density lipoprotein (-37%) and low density (-37%) was noted. Inversely, high-density lipoprotein cholesterol and LCAT activity were enhanced by 19% and 77%, respectively. However, the atherogenicity index and membrane fluidity were reduced (P<0.05).
  
  
  CONCLUSIONS
  Sardine by-products probably by their bioactive compounds properties seem to have antihypertensive, antidiabetic, hypolipidemic and antiatherogenic properties that could prevent and/or attenuate some metabolic disorders associated with obesity.
authors.affiliation: Laboratoire de nutrition clinique et métabolique (LNCM), faculté des sciences de la nature et de la vie, université d'Oran 1 Ahmed Ben Bella, BP 1524 El m'nouer, 31100 Oran, Algérie. Electronic address: affane.fouad@edu.univ-oran1.dz.
authors.forename: F
authors.initials: F
authors.lastname: Affane
authors.affiliation: Laboratoire de nutrition clinique et métabolique (LNCM), faculté des sciences de la nature et de la vie, université d'Oran 1 Ahmed Ben Bella, BP 1524 El m'nouer, 31100 Oran, Algérie.
authors.forename: N
authors.initials: N
authors.lastname: Boukhari Benahmed Daidj
authors.affiliation: Laboratoire de nutrition clinique et métabolique (LNCM), faculté des sciences de la nature et de la vie, université d'Oran 1 Ahmed Ben Bella, BP 1524 El m'nouer, 31100 Oran, Algérie.
authors.forename: S
authors.initials: S
authors.lastname: Louala
authors.affiliation: Laboratoire de nutrition clinique et métabolique (LNCM), faculté des sciences de la nature et de la vie, université d'Oran 1 Ahmed Ben Bella, BP 1524 El m'nouer, 31100 Oran, Algérie.
authors.forename: A N
authors.initials: AN
authors.lastname: Munezero
authors.affiliation: Laboratoire de nutrition clinique et métabolique (LNCM), faculté des sciences de la nature et de la vie, université d'Oran 1 Ahmed Ben Bella, BP 1524 El m'nouer, 31100 Oran, Algérie.
authors.forename: M Y
authors.initials: MY
authors.lastname: Lamri-Senhadji
mesh_terms: D000818:Animals; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000097:blood / Q000188:drug therapy*; D005395:Fish Oils / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep; D016896:Treatment Outcome
chemical_list: D005395:Fish Oils
keywords: By-products; Coproduits; Marqueurs pro-athérogènes; Obesity; Obesogenic diet; Obésité; Pro-atherogenic markers; Régime obésogène; Sardine