title: Primary synovial sarcoma of the scalp: Report of case with a clinicopathological and molecular cytogenetic study.
abstract: Synovial sarcoma (SS) arising primarily in the scalp was scarcely reported. Here we described a subcutaneous mass in the right parietal region of the scalp of a 39year-old male patient. It has been present for 10years and enlarged recently. It was initially suspected as hemangioma by magnetic resonance imaging (MRI), but the histological examination revealed a sarcoma rich of spindle cells reminiscent of SS. Therefore, immunohistochemistry, florescence in site hybridization (FISH), reverse transcription-polymerase chain reaction (RT-PCR) and DNA sequencing were performed to determine the final diagnosis as biphasic SS. The detailed description of primary scalp SS might help differential diagnosis of scalp soft tumors.
authors.affiliation: Department of Pathology, Zhenjiang First People's Hospital, Affiliated to Jiangsu University, Zhenjiang, Jiangsu Province 212002, China; Department of Pathology, Zhenjiang Integrated Traditional Chinese and Western Medicine Hospital, Affiliated to Jiangsu University, Zhenjiang, Jiangsu Province 212002, China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Hu
authors.affiliation: Department of Pathology, Zhenjiang First People's Hospital, Affiliated to Jiangsu University, Zhenjiang, Jiangsu Province 212002, China. Electronic address: 18912802271@163.com.
authors.forename: Miao
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D001483:Base Sequence; D020732:Cytogenetic Analysis; D015894:Genome, Human; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008279:Magnetic Resonance Imaging; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D016133:Polymerase Chain Reaction; D013584:Sarcoma, Synovial / Q000235:genetics* / Q000473:pathology*; D012535:Scalp / Q000473:pathology*; D017422:Sequence Analysis, DNA
chemical_list: D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein
keywords: Differential diagnosis; Head neoplasm; Primary; Scalp; Synovial sarcoma