title: Inter- and intraobserver agreement of ADC measurements of lung cancer in free breathing, breath-hold and respiratory triggered diffusion-weighted MRI.
abstract: OBJECTIVE
  To prospectively evaluate the inter- and intraobserver agreement of apparent diffusion coefficient (ADC) measurements in free breathing, breath-hold, and respiratory triggered diffusion-weighted imaging (DWI) of lung cancer.
  
  
  METHODS
  Twenty-two patients with lung cancer (tumor size >2cm) underwent DWIs (3.0T) in three imaging methods. Lesion ADCs were measured twice by both of the two independent observers and compared.
  
  
  RESULTS
  No statistical significance was found among methods, though respiratory-triggered DWI tended to have higher ADCs than breath-hold DWI. Great inter- and intraobserver agreement was shown.
  
  
  CONCLUSIONS
  ADCs had good inter- and intraobserver agreement in all three DWI methods.
authors.affiliation: Department of Radiology, First Affiliated Hospital of Soochow University, 188 Shixi Street, Suzhou, Jiangsu, PR China, 215006; Department of Radiology, Second Affiliated Hospital of Nantong University, 6 Hai'er Road, Chongchuan District, Nantong, Jiangsu, PR China, 226001.
authors.forename: Lei
authors.initials: L
authors.lastname: Cui
authors.affiliation: Department of Radiology, Second Affiliated Hospital of Nantong University, 6 Hai'er Road, Chongchuan District, Nantong, Jiangsu, PR China, 226001.
authors.forename: Jian-Bing
authors.initials: JB
authors.lastname: Yin
authors.affiliation: Department of Radiology, First Affiliated Hospital of Soochow University, 188 Shixi Street, Suzhou, Jiangsu, PR China, 215006. Electronic address: drhuchunhong@163.com.
authors.forename: Chun-Hong
authors.initials: CH
authors.lastname: Hu
authors.affiliation: Department of Radiology, Second Affiliated Hospital of Nantong University, 6 Hai'er Road, Chongchuan District, Nantong, Jiangsu, PR China, 226001. Electronic address: gongshenchu@126.com.
authors.forename: Shen-Chu
authors.initials: SC
authors.lastname: Gong
authors.affiliation: Department of Radiology, Second Affiliated Hospital of Nantong University, 6 Hai'er Road, Chongchuan District, Nantong, Jiangsu, PR China, 226001.
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Xu
authors.affiliation: Department of Radiology, Second Affiliated Hospital of Nantong University, 6 Hai'er Road, Chongchuan District, Nantong, Jiangsu, PR China, 226001.
authors.forename: Ju-Shun
authors.initials: JS
authors.lastname: Yang
mesh_terms: D000368:Aged; D062485:Breath Holding; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results
keywords: Apparent diffusion coefficient; Diffusion-weighted imaging; Lung cancer; Observer agreement; Reproducibility