title: Glucagon-Like Peptide-1 Receptor Agonists: Beta-Cell Protection or Exhaustion?
abstract: Glucagon-like peptide (GLP)-1 receptor agonists enhance insulin secretion and may improve pancreatic islet cell function. However, GLP-1 receptor (GLP-1R) agonist treatment may have more complex, and sometimes deleterious, effects on beta cells. We discuss the concepts of beta cell protection versus exhaustion for different GLP-1R agonists based on recent data.
authors.affiliation: Diabetes Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands; Department of Pathology and Laboratory Medicine, Child and Family Research Institute, The University of British Columbia, Vancouver, Canada. Electronic address: d.vanraalte@vumc.nl.
authors.forename: Daniël H
authors.initials: DH
authors.lastname: van Raalte
authors.affiliation: Department of Pathology and Laboratory Medicine, Child and Family Research Institute, The University of British Columbia, Vancouver, Canada; Department of Surgery, Child and Family Research Institute, The University of British Columbia, Vancouver, Canada.
authors.forename: C Bruce
authors.initials: CB
authors.lastname: Verchere
mesh_terms: D000818:Animals; D052216:Glucagon-Like Peptide 1 / Q000031:analogs & derivatives / Q000494:pharmacology*; D000067757:Glucagon-Like Peptide-1 Receptor / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000187:drug effects* / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D000097789:Glucagon-Like Peptide-1 Receptor Agonists
chemical_list: D000067757:Glucagon-Like Peptide-1 Receptor; D007328:Insulin; D052216:Glucagon-Like Peptide 1; D000097789:Glucagon-Like Peptide-1 Receptor Agonists
keywords: Glucagon-like peptide (GLP)-1 receptor agonists; beta-cell exhaustion; beta-cell protection; chronic treatment; insulin secretion