title: Transition from inflammation to proliferation: a critical step during wound healing.
abstract: The ability to rapidly restore the integrity of a broken skin barrier is critical and is the ultimate goal of therapies for hard-to-heal-ulcers. Unfortunately effective treatments to enhance healing and reduce scarring are still lacking. A deeper understanding of the physiology of normal repair and of the pathology of delayed healing is a prerequisite for the development of more effective therapeutic interventions. Transition from the inflammatory to the proliferative phase is a key step during healing and accumulating evidence associates a compromised transition with wound healing disorders. Thus, targeting factors that impact this phase transition may offer a rationale for therapeutic development. This review summarizes mechanisms regulating the inflammation-proliferation transition at cellular and molecular levels. We propose that identification of such mechanisms will reveal promising targets for development of more effective therapies.
authors.affiliation: Unit of Dermatology and Venereology, Molecular Dermatology Research Group, Department of Medicine, Center for Molecular Medicine (CMM), L8:02, Karolinska Institutet, SE-171 76, Stockholm, Sweden. ning.xu@ki.se.|Unit of Dermatology and Venereology, Karolinska University Hospital, Solna, Sweden. ning.xu@ki.se.
authors.forename: Ning Xu
authors.identifier: 0000-0003-4868-3798
authors.initials: NX
authors.lastname: Landén
authors.affiliation: Unit of Dermatology and Venereology, Molecular Dermatology Research Group, Department of Medicine, Center for Molecular Medicine (CMM), L8:02, Karolinska Institutet, SE-171 76, Stockholm, Sweden.|Unit of Dermatology and Venereology, Karolinska University Hospital, Solna, Sweden.
authors.forename: Dongqing
authors.initials: D
authors.lastname: Li
authors.affiliation: Unit of Dermatology and Venereology, Molecular Dermatology Research Group, Department of Medicine, Center for Molecular Medicine (CMM), L8:02, Karolinska Institutet, SE-171 76, Stockholm, Sweden.|Unit of Dermatology and Venereology, Karolinska University Hospital, Solna, Sweden.
authors.forename: Mona
authors.initials: M
authors.lastname: Ståhle
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000473:pathology*; D008954:Models, Biological; D012867:Skin / Q000473:pathology; D014945:Wound Healing / Q000235:genetics
keywords: Bioactive lipid mediator; Fibroblast; Macrophage; MicroRNA; Reactive oxygen species; Toll-like receptor; Transcription factor