title: Influence of gross specimen sampling on the incidence of incidental prostatic carcinoma in cystoprostatectomy specimens of patients with bladder carcinoma.
abstract: Reported prostate cancer incidence rates vary greatly among cystoprostatectomy samples. We investigated how the thoroughness of prostate sampling influences prostatic carcinoma incidence in bladder cancer patients. In a retrospective study, 313 cystoprostatectomy cases of urinary bladder carcinoma were analysed for the presence of concurrent prostatic carcinoma. Patients were divided into two groups: patients who had undergone the operation before and after 2007, when a policy of preferably complete prostate sampling in cystoprostatectomy specimens was introduced at our institution. Cases processed after the 2007 recommended sampling changes had a significantly higher rate of incidental prostatic carcinoma and clinically significant prostatic carcinoma than the pre-2007 group (p < 0.0001 and p = 0.003, respectively). Complete prostate processing in cystoprostatectomy specimens results in a higher incidence of incidental prostatic carcinoma than with partial processing. More patients with clinically significant prostate cancer are consequently discovered. In conclusion, we believe that complete prostate sampling should be mandatory.
authors.affiliation: Metka Volavšek. Institute of Pathology. Faculty of Medicine. University of Ljubljana. Korytkova 2. 1000 Ljubljana, Slovenia. e-mail: metka.volavsek@mf.uni-lj.si.
authors.forename: J
authors.initials: J
authors.lastname: Mlakar
authors.forename: M
authors.initials: M
authors.lastname: Volavšek
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D015994:Incidence; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D012189:Retrospective Studies; D013048:Specimen Handling / Q000379:methods* / Q000592:standards; D001749:Urinary Bladder Neoplasms / Q000150:complications*