title: Seroprevalence of acute dengue in a Malaysian tertiary medical centre.
abstract: OBJECTIVE
  The aims of this study were to determine the seroprevalence of acute dengue in Universiti Kebangsaan Malaysia (UKM) Medical Centre and its correlation with selected haematological and biochemical parameters.
  
  
  METHODS
  This cross-sectional study was conducted from January to June 2015. A patient was serologically diagnosed with acute dengue if the dengue virus IgG, IgM or NS-1 antigen was reactive.
  
  
  RESULTS
  Out of 1,774 patients suspected to have acute dengue, 1,153 were serologically diagnosed with the infection, resulting in a seroprevalence of 64.9%. Dengue-positive patients had a lower mean platelet count (89 × 10(9)/L) compared to the dengue-negative patients (171 × 10(9)/L) (p<0.0001). The mean total white cell count was also lower in the dengue-positive cases (4.7 × 10(9)/L vs. 7.2 × 10(9)/L; p<0.0001). The mean haematocrit was higher in patients with acute dengue (42.5% vs. 40.0%; p<0.0001). Likewise, the serum alanine transaminase level was also higher in patients with acute dengue (108 U/L vs. 54 U/L; p<0.0001).
  
  
  CONCLUSIONS
  Dengue is very prevalent in UKM Medical Centre as most patients suspected to have acute dengue had serological evidence of the infection. The platelet count was the single most likely parameter to be abnormal (i.e. low) in patients with acute dengue.
authors.affiliation: Chuan Hun Ding, Department of Medical Microbiology & Immunology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
authors.forename: Chuan Hun
authors.initials: CH
authors.lastname: Ding
authors.affiliation: Zetti Zainol Rashid, Department of Medical Microbiology & Immunology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
authors.forename: Zetti Zainol
authors.initials: ZZ
authors.lastname: Rashid
authors.affiliation: Md. Mostafizur Rahman, Department of Medical Microbiology & Immunology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
authors.forename: Md Mostafizur
authors.initials: MM
authors.lastname: Rahman
authors.affiliation: NanFeng Khang, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: NanFeng
authors.initials: N
authors.lastname: Khang
authors.affiliation: Wan Ngor Low, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Wan Ngor
authors.initials: WN
authors.lastname: Low
authors.affiliation: Nurabrar Hussin, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Nurabrar
authors.initials: N
authors.lastname: Hussin
authors.affiliation: Melissa Iqlima Marzuki, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Melissa Iqlima
authors.initials: MI
authors.lastname: Marzuki
authors.affiliation: Alyaa Nadhira Jaafar, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Alyaa Nadhira
authors.initials: AN
authors.lastname: Jaafar
authors.affiliation: Nurul Ain' Nabilla Roslan, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Nurul Ain' Nabilla
authors.initials: NA
authors.lastname: Roslan
authors.affiliation: Terukumar Chandrasekaran, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Terukumar
authors.initials: T
authors.lastname: Chandrasekaran
keywords: DENV; Dengue; IgG; IgM; NS1; Seroprevalence