title: Different stabilities of liposomes containing saturated and unsaturated lipids toward the addition of cyclodextrins.
abstract: Liposomes composed of unsaturated lipids were more stable than those containing saturated lipids toward DMe-β-CDx, DMe-α-CDx and DMe-β-CDx. The Hill coefficient values (n) indicated that the saturated lipid·DMe-CDx complexes had stoichiometric ratios in the range of 1 : 3-1 : 4, while the unsaturated lipid·DMe-CDx complexes had ratios in the range of 1 : 1.5-1 : 3. That is, a cis alkene group in the unsaturated lipids prevented complexation with a second DMe-CDx in the direction toward each acyl chain. Furthermore, the liposomes composed of the unsaturated lipids were much slower to form precipitates upon the addition of α-CDx than those of the saturated lipids. To the best of our knowledge, this is the first example showing that CDxs interact with unsaturated lipids.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima 739-8527, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ikeda
authors.forename: Rikushi
authors.initials: R
authors.lastname: Funada
authors.forename: Kouta
authors.initials: K
authors.lastname: Sugikawa
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D004355:Drug Stability; D057927:Hydrophobic and Hydrophilic Interactions; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*
chemical_list: D003505:Cyclodextrins; D008055:Lipids; D008081:Liposomes