title: Development of an Inhaled Sustained Release Dry Powder Formulation of Salbutamol Sulphate, an Antiasthmatic Drug.
abstract: The present research was aimed to develop and characterize a sustained release dry powder inhalable formulation of salbutamol sulphate. The salbutamol sulphate microparticles were prepared by solvent evaporation method using biodegradable polymer poly (D,L-lactic-co-glycolic acid) to produce salbutamol sulphate microparticle mixed with carrier respirable grade lactose for oral inhalation of dry powder. The drug content were estimated to produce 1 mg sustained release salbutamol sulphate per dose. Total four formulations K1, K2, K3 and K4 were prepared with 1:1, 1:2, 1:3, 1:4 ratio of salbutamol sulphate:poly (D,L-lactic-co-glycolic acid). The developed formulations were studied for physicochemical properties, in vitro drug relase and Anderson cascade impaction studies. The prepared formulations effectively releases drug for 12 h in diffusion bag studies. Based on dissolution performance the 1:1 ratio of salbutamol sulphate:poly (D,L-lactic-co-glycolic acid) produces in vitro release 92.57% at 12 h and having particle size of microparticles (D0.5μm) 5.02±0.6 and the pulmonary deposition of dry powder 34.5±3.21 (respiratory fraction in percentage).
authors.affiliation: Department of Chemical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Kalavakkam, Kancheepuram-603 110, India.
authors.forename: C
authors.initials: C
authors.lastname: Kumaresan
authors.affiliation: Department of Chemical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Kalavakkam, Kancheepuram-603 110, India.
authors.forename: K
authors.initials: K
authors.lastname: Sathishkumar
keywords: Salbutamol; dry powder inhaler; microparticles; sustained release