title: Impact of remaining kidney volume to body weight ratio on renal function in living kidney donors.
abstract: To investigate whether the ratio of remnant kidney volume to body weight (V/W ratio) can impact renal function in donors, 45 living kidney donors were enrolled. Kidney volume was analyzed by magnetic resonance imaging. Renal function was compared between donors with a V/W ratio of < 2.0 mL/kg (n = 23) or ≥ 2.0 mL/kg (n = 22). Donors in both V/W groups showed similar serum creatinine levels and estimated glomerular filtration rates (eGFRs) at 7 days and 1 year, whereas donors with a V/W ratio of < 2.0 mL/kg had significantly higher 24-hour urine protein levels at 1 year (0.54 ± 0.23 g/d vs. 0.33 ± 0.19 g/d, p = 0.028). Multivariate analysis revealed no correlation between the V/W ratio and eGFR at 7 days or 1 year, and a V/W ratio of < 2 mL/kg was not associated with an increased incidence of eGFR < 60 mL/min/1.73 m(2) at 1 year (risk ratio 1.73, 95% confidence interval 0.10-29.47). The V/W ratio correlated inversely with 24-hour urine protein (r = -0.377, p = 0.021) at 1 year, and donors with a V/W ratio of < 2.0 mL/kg were more likely to show 24-hour urine protein >300 mg (risk ratio 1.70, 95% confidence interval 1.08-2.67) at 1 year. Donors with lower V/W ratios have higher 24-hour urinary protein levels at 1 year after transplantation. These findings suggest that the V/W ratio may be useful for kidney selection.
authors.affiliation: Department of Urology, Urology Institute and Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Turun
authors.initials: T
authors.lastname: Song
authors.affiliation: Department of Urology, Urology Institute and Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Zhengsheng
authors.initials: Z
authors.lastname: Rao
authors.affiliation: Department of Urology, Urology Institute and Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Department of Urology, Urology Institute and Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Jinpeng
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Urology, Urology Institute and Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Zhongli
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Urology, Urology Institute and Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Xianding
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Urology, Urology Institute and Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, China. Electronic address: Kidney5@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Lin
mesh_terms: D001835:Body Weight; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D007677:Kidney Function Tests; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011300:Preoperative Care
keywords: Body weight; Kidney function; Kidney volume; Living donor; Proteinuria