title: You Are What You Eat: Linking Metabolic Asymmetry and Cell Fate Choice.
abstract: To defend against pathogens, activated immune cells must rapidly produce diverse lymphocyte subtypes. In a recent report in Nature, Verbist et al. (2016) describe how a regulatory loop acting between metabolic and transcriptional programs, centered around the asymmetric cell division machinery and the proto-oncogene c-Myc, establishes distinct T cell fates.
authors.affiliation: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria.
authors.forename: Lisa
authors.initials: L
authors.lastname: Landskron
authors.affiliation: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria. Electronic address: juergen.knoblich@imba.oeaw.ac.at.
authors.forename: Juergen A
authors.initials: JA
authors.lastname: Knoblich
mesh_terms: D000818:Animals; D019070:Cell Lineage; D006801:Humans; D007109:Immunity; D008660:Metabolism; D008954:Models, Biological; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc