title: Association Between Sleep Problems and Perceived Cognitive Dysfunction Over 12 Months in Individuals with Multiple Sclerosis.
abstract: Sleep problems are highly prevalent among individuals with multiple sclerosis (MS); however, the relationship between sleep problems and cognitive dysfunction is poorly understood in this population. In the present study, 163 individuals with MS and depression, fatigue, or pain completed self-report measures of sleep, cognitive dysfunction, and relevant demographic and clinical characteristics (e.g., disability severity, depressive symptomatology, pain intensity, fatigue impact) at four time points over 12 months. Mixed-effects regression demonstrated that poorer sleep was independently associated with worse perceived cognitive dysfunction (β = -0.05, p = .001), beyond the influence of depressive symptomatology. Fatigue impact was found to partially mediate this relationship. Results suggest that for individuals with MS and depression, fatigue, or pain, self-reported sleep problems are related to perceived cognitive dysfunction, and that fatigue impact accounts for part of this relationship.
authors.affiliation: a Department of Rehabilitation Medicine , University of Washington , Seattle , Washington , USA.|b MS Center of Excellence-West , VA Puget Sound Health Care System , Seattle , Washington , USA.
authors.forename: Abbey J
authors.initials: AJ
authors.lastname: Hughes
authors.affiliation: a Department of Rehabilitation Medicine , University of Washington , Seattle , Washington , USA.|b MS Center of Excellence-West , VA Puget Sound Health Care System , Seattle , Washington , USA.
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Turner
authors.affiliation: a Department of Rehabilitation Medicine , University of Washington , Seattle , Washington , USA.|c Department of Neurology , University of Washington , Seattle , Washington , USA.
authors.forename: Kevin N
authors.initials: KN
authors.lastname: Alschuler
authors.affiliation: d Department of Psychiatry and Behavioral Sciences , University of Washington , Seattle , Washington , USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Atkins
authors.affiliation: e Department of Physical Medicine and Rehabilitation , Johns Hopkins University , Baltimore , Maryland , USA.
authors.forename: Meghan
authors.initials: M
authors.lastname: Beier
authors.affiliation: a Department of Rehabilitation Medicine , University of Washington , Seattle , Washington , USA.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Amtmann
authors.affiliation: a Department of Rehabilitation Medicine , University of Washington , Seattle , Washington , USA.
authors.forename: Dawn M
authors.initials: DM
authors.lastname: Ehde
mesh_terms: D000328:Adult; D000368:Aged; D060825:Cognitive Dysfunction / Q000150:complications*; D003863:Depression / Q000150:complications; D005221:Fatigue / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000523:psychology*; D010146:Pain / Q000150:complications; D057566:Self Report; D012890:Sleep; D012893:Sleep Wake Disorders / Q000150:complications* / Q000523:psychology*; D013997:Time Factors