title: Serum Parathyroid Hormone Levels Predict Discharge and Readmission for Heart Failure.
abstract: OBJECTIVE
  Parathyroid hormone (PTH) levels are useful as a prognostic factor of chronic heart failure (HF) and can predict hospitalization for HF. It is unknown whether serum PTH levels in hospitalized patients with HF can predict discharge and if admission, discharge, or change from admission to discharge PTH measure is the most important predictor of readmission and/or death.
  
  
  METHODS
  A total of 125 consecutive hospitalized patients with HF were enrolled into this study. The receiver operating characteristic (ROC) curves indicated the predicted values of PTH for readmission due to HF and the optimal cutoff points of PTH levels for discharge. The binary logistic regression model indicated an association between PTH levels and readmission due to HF.
  
  
  RESULTS
  The PTH level on admission was positively correlated with the New York Heart Association class and N-terminal pro-B-type natriuretic peptide level. The ROC curves showed that the PTH level at discharge (PTHdis) was of predictive value for readmission within 1 year due to HF. A PTHdis level <45.2 pg/mL was the best cutoff point for discharge, with a sensitivity of 72.1%, specificity of 61.5%, and area under the ROC curve of 0.693 (95% confidence interval [CI] 0.598-0.788). The results of logistic regression analysis showed that PTHdis had an odds ratio of 1.035 for readmission due to HF (95% CI 1.005-1.067).
  
  
  CONCLUSIONS
  Serum PTH levels in hospitalized patients with HF were shown to be an independent predictor of discharge and PTHdis was the best predictor of readmission and/or death within 1 year due to HF.
authors.affiliation: Department of Cardiology, No. 101 Hospital of PLA; Wuxi Institute of Clinical, Anhui Medical University , Wuxi, Jiangsu Province, China .
authors.forename: Gangyong
authors.initials: G
authors.lastname: Wu
authors.affiliation: Department of Cardiology, No. 101 Hospital of PLA; Wuxi Institute of Clinical, Anhui Medical University , Wuxi, Jiangsu Province, China .
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Cardiology, No. 101 Hospital of PLA; Wuxi Institute of Clinical, Anhui Medical University , Wuxi, Jiangsu Province, China .
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Cardiology, No. 101 Hospital of PLA; Wuxi Institute of Clinical, Anhui Medical University , Wuxi, Jiangsu Province, China .
authors.forename: Haibing
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, No. 101 Hospital of PLA; Wuxi Institute of Clinical, Anhui Medical University , Wuxi, Jiangsu Province, China .
authors.forename: Lulu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiology, No. 101 Hospital of PLA; Wuxi Institute of Clinical, Anhui Medical University , Wuxi, Jiangsu Province, China .
authors.forename: Tianxiao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Cardiology, No. 101 Hospital of PLA; Wuxi Institute of Clinical, Anhui Medical University , Wuxi, Jiangsu Province, China .
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Cardiology, No. 101 Hospital of PLA; Wuxi Institute of Clinical, Anhui Medical University , Wuxi, Jiangsu Province, China .
authors.forename: Dongmei
authors.initials: D
authors.lastname: An
authors.affiliation: Department of Cardiology, No. 101 Hospital of PLA; Wuxi Institute of Clinical, Anhui Medical University , Wuxi, Jiangsu Province, China .
authors.forename: Li
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Cardiology, No. 101 Hospital of PLA; Wuxi Institute of Clinical, Anhui Medical University , Wuxi, Jiangsu Province, China .
authors.forename: Yang
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Department of Cardiology, No. 101 Hospital of PLA; Wuxi Institute of Clinical, Anhui Medical University , Wuxi, Jiangsu Province, China .
authors.forename: Gangjun
authors.initials: G
authors.lastname: Zong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D005544:Forecasting; D006333:Heart Failure / Q000097:blood* / Q000628:therapy; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood*; D010359:Patient Readmission; D011379:Prognosis; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D020097:Natriuretic Peptide, Brain