title: Cutaneous manifestations in neuro-oncology: clinically relevant tumor and treatment associated dermatologic findings.
abstract: Skin findings are a rare but important aspect of the evaluation and management of patients with tumors of the nervous system. Skin findings have the highest prevalence in genetic tumor syndromes termed neuro-genodermatoses, which include neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and tuberous sclerosis. Skin changes are observed in patients with non-syndromic nervous system malignancy, often as a result of pharmacotherapy. The skin may also manifest findings in paraneoplastic conditions that affect the nervous system, providing an early indication of underlying neoplasm, including dermatomyosistis, neuropathic itch, and brachioradial pruritus. In this article, we review the major cutaneous findings in patients with tumors of the brain, spine, and peripheral nervous system focusing on (1) cutaneous manifestations of genetic and sporadic primary nervous system tumor syndromes, and (2) paraneoplastic neurological syndromes with prominent cutaneous features.
authors.affiliation: Department of Neurology, Wake Forest School of Medicine, Winston Salem, NC; Department of Neurology and Oncology, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address: rstrowd@wakehealth.edu.
authors.forename: Roy E
authors.initials: RE
authors.lastname: Strowd
authors.affiliation: Department of Dermatology, Wake Forest Baptist Medical Center, Winston Salem, NC.
authors.forename: Lindsay C
authors.initials: LC
authors.lastname: Strowd
authors.affiliation: Department of Neurology, Wake Forest School of Medicine, Winston Salem, NC; Department of Neurology and Oncology, Johns Hopkins School of Medicine, Baltimore, MD.
authors.forename: Jaishri O
authors.initials: JO
authors.lastname: Blakeley
mesh_terms: D003882:Dermatomyositis / Q000209:etiology / Q000473:pathology; D006801:Humans; D009380:Neoplasms, Nerve Tissue / Q000473:pathology* / Q000628:therapy; D009456:Neurofibromatosis 1 / Q000473:pathology / Q000628:therapy; D016518:Neurofibromatosis 2 / Q000473:pathology / Q000628:therapy; D010257:Paraneoplastic Syndromes / Q000473:pathology*; D014402:Tuberous Sclerosis / Q000473:pathology* / Q000628:therapy
keywords: Brachioradial pruritus; Dermatomyositis; Neuro-oncology; Neurofibromatosis; Neuropathic itch; Tuberous sclerosis