title: The effect of vitamin D and bisphosphonate on fracture healing: An experimental study.
abstract: BACKGROUND
  The aim of the study was to evaluate the effects of the using bisphosphonate, vitamin D, and a combination of bisphosphonate and vitamin D on fracture healing, by comparison of radiological and histological findings of the study groups and a control group.
  
  
  METHODS
  A total of 24 rats were randomly divided into 4 groups. A mid-third fracture was created in the femur of all rats. Saline was administered to Group A, bisphosphonate (Alendronate) to Group B, bisphosphonate (Alendronate) + vitamin D (Calcitriol) to Group C and vitamin D (Calcitriol) to Group D. All preparations were administered orally for 28 days.
  
  
  RESULTS
  No statistically significant difference was determined between the groups in respect of the effect on fracture healing according to radiological findings. The histological findings of fracture healing showed Groups B and C to be significantly more advanced than Group A (p = 0.017, p = 0.009). However no significant difference was found in Group D comparison with Group A (p = 0.224).
  
  
  CONCLUSIONS
  According to the histological findings, advanced fracture healing was seen in the groups administered with bisphosphonate or combined bisphosphonate and vitamin D compared to the use of vitamin D alone and the control group. It was concluded that bisphosphonate treatment combined with vitamin D can be used safely without any negative effect on fracture healing.
authors.affiliation: Department of Orthopedics, Mugla Sıtkı Kocman University, Mugla, Turkey.
authors.forename: Nevres Hürriyet
authors.initials: NH
authors.lastname: Aydoğan
authors.affiliation: Department of Orthopedics, Simav Public Hospital, Kütahya, Turkey.
authors.forename: İrfan
authors.initials: İ
authors.lastname: Özel
authors.affiliation: Department of Orthopedics, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: İltar
authors.affiliation: Department of Orthopedics, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Talip
authors.initials: T
authors.lastname: Kara
authors.affiliation: Department of Orthopedics, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Özmeriç
authors.affiliation: Department of Orthopedics, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Kadir Bahadır
authors.initials: KB
authors.lastname: Alemdaroğlu
keywords: Bisphosphonates; Experimental study; Fracture healing; Osteoporosis; Vitamin D supplements