title: Association of statin use and stress-induced hyperglycemia in patients with acute ST-elevation myocardial infarction.
abstract: BACKGROUND
  Only a few information is available on the risk of stress hyperglycemia following acute myocardial infarction after statin use. We investigate the association of stress-induced hyperglycemia following statin use in patients with acute myocardial infarction.
  
  
  METHODS
  An observational analysis of 476 consecutive patients who suffered acute myocardial infarction was carried out. All selected patients were divided into diabetes mellitus and non-diabetes based on the presence or absence of diabetes. The cardiac incidence of in-hospital and stress-induced hyperglycemia was recorded.
  
  
  RESULTS
  Among patients with stress hyperglycemia in non-diabetes mellitus subgroups, the average fasting plasma glucose values in statin users were higher than in non-statin users (P < 0.05). But in diabetes mellitus subgroups, the average fasting plasma glucose did not have a significant difference between statin users and non-statin users (P > 0.05). In non-diabetes mellitus patients, the incidence of stress hyperglycemia with statin therapy was significantly higher than with non-statin therapy (P = 0.003). But in diabetes mellitus patients group, there is no significant difference in incidence of stress hyperglycemia between patients with statin therapy and patients without statin therapy (P = 0.902).The incidence of heart failure and in-hospital mortality of acute myocardial infarction in patients with stress-induced hyperglycemia was significantly higher than in non-hyperglycemia patients (P < 0.05).
  
  
  CONCLUSIONS
  Statins are related to higher stress hyperglycemia and cardiac incidences after acute myocardial infarction.
authors.affiliation: Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Yan
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Ma
authors.initials: M
authors.lastname: Qin
authors.affiliation: Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
authors.forename: Yang S
authors.initials: YS
authors.lastname: Juan
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Li Y
authors.initials: LY
authors.lastname: Tao
authors.affiliation: Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
authors.forename: Gao M
authors.initials: GM
authors.lastname: Dong
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Zeng
authors.initials: Z
authors.lastname: Zechun
authors.affiliation: Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
authors.forename: Yang X
authors.initials: YX
authors.lastname: Chun
authors.affiliation: Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
authors.forename: Cong H
authors.initials: CH
authors.lastname: Liang
authors.affiliation: Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yin
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Kang
keywords: Statins; acute myocardial infarction; stress-induced hyperglycemia