title: Adaptogenic activity of a complex biomedication based on a northern renewable raw material.
abstract: BACKGROUND
  One of the methods of increasing bioavailability, and thus the therapeutic effectiveness of an active substances, along with decreasing its required dosage, is to generate highly effective "carrier: active substances" complexes where the active carrier both increases the bioavailability of the active substance at lower doses and has a detoxifying activity.
  
  
  OBJECTIVE
  the aim of this work was study the properties of the carrier from the lichen thallome in both its solid pharmaceutical form and in combination with Rhodiola rosea.
  
  
  METHODS
  the physiologically active plant extracts with enhanced adaptogenic pharmacological activity based on plant substances growing in Yakutia: Cladonia lichen thalli and Rhodiola rosea (Rhodiolarosea, fam.Crassulaceae) rhizomes, combined in a raw material dry-weight ratio of 10:1 We used a one step, solvent-free process, involving the use of mechanochemical ball mills relying on centrifugal acceleration of the 10-30 g grinding bodies.
  
  
  RESULTS
  A single-stage mechanochemical technology has been developed for obtaining highly effective solid-phase biocomplexes based on a"multipurpose active filler" - a polymer matrix of lichen β-oligosaccharides. It has been shown that lichen, is a raw material from which can be sourced a filler with a strong adsorption activity for solid pharmaceutical forms.
  
  
  CONCLUSIONS
  It is considered statistically significant that a bicomponent plant mechanocomplex based on this filler - lichen β-oligosaccharides and small amounts of Rhodiola rosea has a wide spectrum of adaptogenic action, increasing the resistance of laboratory animals to the effects of physical exercise and a variety of extreme factors.
authors.affiliation: Federal State Autonomic Educational Institution of Higher Professional Training North-East Federal University n.a. M.K. Ammosov Yakutsk city, Republic of Sakha (Yakutia), Russia, anshakova_v@mail.ru.
authors.forename: Vera V
authors.initials: VV
authors.lastname: Anshakova
authors.affiliation: Federal State Autonomic Educational Institution of Higher Professional Training North-East Federal University n.a. M.K. Ammosov Yakutsk city, Republic of Sakha (Yakutia), Russia.
authors.forename: Albina V
authors.initials: AV
authors.lastname: Stepanova
authors.affiliation: Federal State Autonomic Educational Institution of Higher Professional Training North-East Federal University n.a. M.K. Ammosov Yakutsk city, Republic of Sakha (Yakutia), Russia.
authors.forename: Dimitrii M
authors.initials: DM
authors.lastname: Uvarov
authors.affiliation: Federal State Autonomic Educational Institution of Higher Professional Training North-East Federal University n.a. M.K. Ammosov Yakutsk city, Republic of Sakha (Yakutia), Russia.
authors.forename: Aigerim Sh
authors.initials: ASh
authors.lastname: Smagulova
authors.affiliation: Federal State Autonomic Educational Institution of Higher Professional Training North-East Federal University n.a. M.K. Ammosov Yakutsk city, Republic of Sakha (Yakutia), Russia.
authors.forename: Ksenia N
authors.initials: KN
authors.lastname: Naumova
authors.affiliation: Federal State Autonomic Educational Institution of Higher Professional Training North-East Federal University n.a. M.K. Ammosov Yakutsk city, Republic of Sakha (Yakutia), Russia.
authors.forename: Petr P
authors.initials: PP
authors.lastname: Vasiliev
mesh_terms: D000818:Animals; D001682:Biological Availability; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008011:Lichens / Q000737:chemistry*; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000493:pharmacokinetics*; D029771:Rhodiola / Q000737:chemistry*; D012426:Russia; D013550:Swimming / Q000502:physiology*
chemical_list: D010936:Plant Extracts