title: Seroprevalence of Crimean-Congo Hemorrhagic Fever in Turkey's Van Province.
abstract: Crimean-Congo hemorrhagic fever (CCHF) is an endemic tick-borne viral disease that affects both animals and humans. This study aims to determine the seroprevalence of CCHF in Turkey's Van province using analysis of blood samples obtained from people living in the region. Blood specimens were taken from healthy subjects living in Van province and some of the surrounding villages between January and July 2012. Blood samples were initially tested using a CCHF virus (CCHFV) IgM IgG kit for anti-CCHFV IgG, followed by anti-CCHFV IgM determination of any IgG positive blood samples. IgM-positive specimens were re-confirmed using real-time polymerase chain reaction (qPCR). One hundred and 7 men and 261 women were included in the study. Fifty-three blood specimens (14.4%) were anti-CCHFV IgG positive, and 2 of these were anti-CCHFV IgM positive. Two blood samples with anti-CCHFV IgM seropositivity tested negative using qPCR, indicating chronic infections. Locality, sex, and a history of tick bites did not significantly affect anti-CCHFV IgG seropositivity. Although the incidence of anti-CCHFV IgG in blood specimens was 14.4%, no deaths have yet been reported in Turkey's Van province. It is imperative that clinical CCHFV tests be implemented for people at high risk of developing CCHFV-related complications.
authors.affiliation: Department of Microbiology, Medical School Research Hospital, Yüzüncü Yıl University.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Bayram
authors.forename: Mehmet
authors.initials: M
authors.lastname: Parlak
authors.forename: Ayşe
authors.initials: A
authors.lastname: Özkaçmaz
authors.forename: Aytekin
authors.initials: A
authors.lastname: Çıkman
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Güdücüoǧlu
authors.forename: Selçuk
authors.initials: S
authors.lastname: Kılıç
authors.forename: Mustafa
authors.initials: M
authors.lastname: Berktaş
authors.forename: Cenk A
authors.initials: CA
authors.lastname: Andac
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D003430:Cross-Sectional Studies; D016021:Epidemiologic Studies; D005260:Female; D006479:Hemorrhagic Fever, Crimean / Q000453:epidemiology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D060888:Real-Time Polymerase Chain Reaction; D016036:Seroepidemiologic Studies; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral