title: Controlled release matrix tablets of glipizide: Influence of different grades of ethocel and Co-excipient on drug release.
abstract: The aim of the current study was to formulate and evaluate glipizide controlled release matrix tablets by means of different grades of polymer Ethoceland different co-excipients in order to evaluate their effect on drug release profiles during in vitro dissolution studies. Type II diabetes mellitus is usually treated with Glipizide. Glipizide belongs to sulfonylurea group. Gastric disturbance and severe hypoglycemia has been observed after taking glipizide orally. To overcome these problems, controlled release matrices were developed using different grades of ethyl cellulose polymer with a drug-polymer ratio of 1:3by the direct compression method. The effect on drug release of partial replacement of lactose by different co-excipients, HPMC K100M, starch and CMC, were also studied. Diameter, thickness, hardness, friability, weight variations, drug contents of formulations were tested, these properties were within prescribed limits. Co-excipients and polymer containing formulations were compared to the without co-excipients and polymer containing formulations with respect to their release profile. After a 24-hour release study, ethyl cellulose polymer containing formulation exhibited prolonged release for 5-16 hours; however the polymer Ethocel (R) standard FP 7 Premium without co-excipient containing formulation exhibited controlled release for 24 hours. Incompatibility was investigated between drugs, co-excipient DSC and polymer study was performed and any type of interaction was not found. Different kinetic models were used to study the release mechanism. An enhanced release rate was observed in case of excipients containing formulations.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, Dera Ismail Khan KPK, Pakistan / Department of Pharmacy, Havelian Campus, Hazara University, Mansehra, KPK, Pakistan.
authors.forename: Saif Ullah
authors.initials: SU
authors.lastname: Mehsud
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, Dera Ismail Khan KPK, Pakistan /Department of Pharmacy, Havelian Campus, Hazara University, Mansehra, KPK, Pakistan / Department of Pharmacy, Quaid-e-Azam University, Islamabad, Pakistan.
authors.forename: Gul Majid
authors.initials: GM
authors.lastname: Khan
authors.affiliation: Department of Pharmacy, University of Poonch, Rawalakot, Azad Kashmir.
authors.forename: Abid
authors.initials: A
authors.lastname: Hussain
authors.affiliation: Department of Eastern Medicine, University of Poonch, Rawalakot, Azad Kashmir.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Akram
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Gomal University, Dera Ismail Khan KPK, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Akhlaq
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, Dera Ismail Khan KPK, Pakistan.
authors.forename: Kamran Ahmad
authors.initials: KA
authors.lastname: Khan
authors.affiliation: Department of Pharmacy, Comsat University, Abbotabad, KPK, Pakistan.
authors.forename: Abdul
authors.initials: A
authors.lastname: Shakoor
mesh_terms: D002152:Calorimetry, Differential Scanning; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D005079:Excipients / Q000737:chemistry*; D005913:Glipizide / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007004:Hypoglycemic Agents / Q000737:chemistry*; D065347:Hypromellose Derivatives / Q000737:chemistry; D007700:Kinetics; D008956:Models, Chemical; D011208:Powders; D012995:Solubility; D013213:Starch / Q000737:chemistry; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D003692:Delayed-Action Preparations; D005079:Excipients; D007004:Hypoglycemic Agents; D011208:Powders; D013607:Tablets; D065347:Hypromellose Derivatives; C013517:ethyl cellulose; D002482:Cellulose; D013213:Starch; D002266:Carboxymethylcellulose Sodium; D005913:Glipizide