title: Effect of body weight on fixed dose of diclofenac for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis.
abstract: OBJECTIVE
  The aim of this study was to assess the influence of patient body weight on the clinical effect of 100 mg diclofenac administered as a single dose for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP).
  
  
  METHODS
  All patients subjected to endoscopic retrograde cholangiopancreatography (ERCP) from 2009 to 2014 were evaluated for inclusion. In total, 772 patients were included of whom 378 (49%) received diclofenac prophylaxis.
  
  
  RESULTS
  In the diclofenac prophylaxis group, body weight was higher in patients with PEP (mean ± SD: 82 ± 18 kg) than in patients without PEP (74 ± 18 kg) (p = 0.029). In patients not receiving prophylaxis, body weight was not associated with the occurrence of PEP (mean ± SD: 77 ± 18 vs 75 ± 18 kg, respectively, p = 0.450). In an adjusted analysis, higher patient body weight was inversely associated with the clinical effect of 100 mg diclofenac for the prophylaxis of PEP.
  
  
  CONCLUSIONS
  High patient body weight was associated with a reduced effect of 100 mg diclofenac for prophylaxis of PEP.
authors.affiliation: a Digestive Disease Center, Bispebjerg Hospital , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Bonna
authors.initials: B
authors.lastname: Leerhøy
authors.affiliation: a Digestive Disease Center, Bispebjerg Hospital , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Andreas
authors.initials: A
authors.lastname: Nordholm-Carstensen
authors.affiliation: b Department of Gastroenterology and Gastrointestinal Surgery , Hvidovre Hospital, University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Srdan
authors.initials: S
authors.lastname: Novovic
authors.affiliation: a Digestive Disease Center, Bispebjerg Hospital , University of Copenhagen , Copenhagen , Denmark ;|c AstraZeneca, Research and Development , Gothenburg , Sweden.
authors.forename: Mark Berner
authors.initials: MB
authors.lastname: Hansen
authors.affiliation: a Digestive Disease Center, Bispebjerg Hospital , University of Copenhagen , Copenhagen , Denmark ;
authors.forename: Lars Nannestad
authors.initials: LN
authors.lastname: Jørgensen
mesh_terms: D000208:Acute Disease; D000368:Aged; D001835:Body Weight; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects*; D004008:Diclofenac / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D010195:Pancreatitis / Q000209:etiology / Q000517:prevention & control*
chemical_list: D004008:Diclofenac
keywords: Acute pancreatitis; ERCP; body weight; diclofenac; nonsteroidal anti-inflammatory drugs; post-ERCP pancreatitis; prevention