title: Impact of a School-Based Intervention Protocol - ACORDA Project - On Adipokines in An Overweight and Obese Pediatric Population.
abstract: There are few reliable studies assessing the effect of physical exercise (PE) on adipokines levels at young ages. Our objective was to study the effects of regular PE on plasma adipokines in pediatric overweight and obesity.
  
  
  
  117 overweight and obese children and adolescents (47% females; 10.2 years) participated in an 8-month longitudinal study divided in two groups: PE group (n = 80), engaged in an after-school PE program; control group (n = 37), with no PE program. Plasma lipids, C-reactive protein (CRP), adiponectin, resistin, leptin, IL-6, IL-1beta, TNF-alpha, insulin and glucose levels were determined.
  
  
  
  contrarily to the control group, the PE group presented reductions in body mass index z-score (BMIzsc) and body fat percentage that were accompanied by an improvement in lipid profile and insulin resistance, a reduction in CRP and TNF-alpha and an increase in adiponectin levels. The reductions in BMIzsc were inversely correlated with changes in adiponectin (r=-0.329, p = .003) and positively correlated with changes in percentage body fat (r = .262, p = .032), triglycerides (r = .228, p = .042) and leptin (r = .285, p = .010).
  
  
  
  Moderate reductions in adiposity improve proinflammatory status in obese children and adolescents. A more substantial reduction in BMIzsc was associated with a greater increment in adiponectin and reduction in leptin.
authors.affiliation: Dept. of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
authors.forename: Henrique
authors.initials: H
authors.lastname: Nascimento
authors.forename: Ana Inês
authors.initials: AI
authors.lastname: Alves
authors.forename: Ana Filipa
authors.initials: AF
authors.lastname: Medeiros
authors.forename: Susana
authors.initials: S
authors.lastname: Coimbra
authors.forename: Cristina
authors.initials: C
authors.lastname: Catarino
authors.forename: Elsa
authors.initials: E
authors.lastname: Bronze-da-Rocha
authors.forename: Elisio
authors.initials: E
authors.lastname: Costa
authors.forename: Petronila
authors.initials: P
authors.lastname: Rocha-Pereira
authors.forename: Gustavo
authors.initials: G
authors.lastname: Silva
authors.forename: Luísa
authors.initials: L
authors.lastname: Aires
authors.forename: André
authors.initials: A
authors.lastname: Seabra
authors.forename: Jorge
authors.initials: J
authors.lastname: Mota
authors.forename: Helena
authors.initials: H
authors.lastname: Ferreira Mansilha
authors.forename: Carla
authors.initials: C
authors.lastname: Rêgo
authors.forename: Alice
authors.initials: A
authors.lastname: Santos-Silva
authors.forename: Luis
authors.initials: L
authors.lastname: Belo
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D050154:Adiposity; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D015444:Exercise; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D050177:Overweight / Q000097:blood*; D063766:Pediatric Obesity / Q000097:blood*; D011174:Portugal; D052243:Resistin / Q000097:blood; D014409:Tumor Necrosis Factor-alpha
chemical_list: C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D001786:Blood Glucose; C508585:IL1B protein, human; C508600:IL6 protein, human; D007328:Insulin; D053583:Interleukin-1beta; D015850:Interleukin-6; D020738:Leptin; C499624:RETN protein, human; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein