title: Production of naphthoquinones and phenolics by a novel isolate Fusarium solani PSC-R of Palk Bay and their industrial applications.
abstract: The present study was attempted to enhance the production of naphthoquinones and phenolics by Fusarium solani PSC-R of Palk Bay origin, which exhibited potent antibacterial, antioxidant and dyeing activity. Maximum productivity of naphthoquinones and phenolics was achieved in potato infusion medium supplemented with 2% sucrose. Addition of nitrogen sources to the medium adversely affected the production of both naphthoquinones and phenolics. An initial pH of 5 and incubation at 31°C for six days at 140rpm was found to increase the yield (123.65mg/g of DW), concentration (867.33mg/l) and total naphthoquinones (602.8μM/g DW) by 7.58, 10.44 and 3.68-fold respectively. Similarly, the antioxidant and antibacterial activity associated with the phenolics of PSC-R increased by 1.5-fold in the optimized medium. The obtained results document the effective means of enhanced production of naphthoquinones and phenolics in the suspension culture of F. solani PSC-R at bioreactor level.
authors.affiliation: Department of Biotechnology, Alagappa University, Karaikudi 630004, India.
authors.forename: Janarthanam
authors.initials: J
authors.lastname: Rathna
authors.affiliation: Department of Industrial Chemistry, Alagappa University, Karaikudi 630003, India.
authors.forename: Kumanan Bharathi
authors.initials: KB
authors.lastname: Yazhini
authors.affiliation: Department of Biotechnology, Alagappa University, Karaikudi 630004, India.
authors.forename: Antony Alex Kennedy
authors.initials: AAK
authors.lastname: Ajilda
authors.affiliation: Department of Industrial Chemistry, Alagappa University, Karaikudi 630003, India.
authors.forename: Halliah Guru Mallesh
authors.initials: HGM
authors.lastname: Prabu
authors.affiliation: Department of Biotechnology, Alagappa University, Karaikudi 630004, India. Electronic address: sk_pandian@rediffmail.com.
authors.forename: Shunmugiah Karutha
authors.initials: SK
authors.lastname: Pandian
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D019149:Bioreactors; D003470:Culture Media / Q000737:chemistry; D005670:Fusarium / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007194:India; D007218:Industrial Microbiology / Q000295:instrumentation / Q000379:methods*; D009285:Naphthoquinones / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism; D010636:Phenols / Q000378:metabolism*; D011198:Solanum tuberosum; D013696:Temperature
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D003470:Culture Media; D009285:Naphthoquinones; D010636:Phenols; D009584:Nitrogen
keywords: Antibacterial; Antioxidant; Fusarium solani; Natural dyes; Palk Bay