title: Stereoselective induction by 2,2',3,4',6-pentachlorobiphenyl in adult zebrafish (Danio rerio): Implication of chirality in oxidative stress and bioaccumulation.
abstract: This study aimed to investigate the oxidative stress process and bioaccumulation the racemic/(-)-/(+)- 2,2',3,4',6-pentachlorobiphenyl were administered to adult zebrafish (Danio rerio) after prolonged exposure of 56-days uptake and 49-days depuration experiments. Stereoselective accumulation was observed in adult samples after racemic exposure as revealed by decreased enantiomer fractions. The two enantiomers of PCB91 accumulated at different rates with logBCFk values close to 3.7, suggesting that they were highly hazardous and persistent pollutants. Exposure to racemic/(-)-/(+)- PCB91 stereoselectively induced oxidative stress owing to changes in reactive oxygen species, malondialdehyde contents, antioxidant enzyme activities and gene expressions in brain and liver tissues. In addition, the stereoselective relationship between bioconcentration and oxidative stress were also presented in this study. Our findings might be helpful for elucidating the environmental risk of the two enantiomers of PCB91 that induce toxicity in aquatic organisms.
authors.affiliation: College of Science, China Agricultural University, Beijing 100193, China; Institute of Quality Standards & Testing Technology for Agro-Products, Key Laboratory of Agro-product Quality and Safety, Chinese Academy of Agricultural Sciences, Key Laboratory of Agri-food Quality and Safety, Ministry of Agriculture, Beijing 100081, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Chai
authors.affiliation: College of Science, China Agricultural University, Beijing 100193, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Cui
authors.affiliation: College of Science, China Agricultural University, Beijing 100193, China.
authors.forename: Xiyan
authors.initials: X
authors.lastname: Mu
authors.affiliation: College of Science, China Agricultural University, Beijing 100193, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: College of Science, China Agricultural University, Beijing 100193, China.
authors.forename: Suzhen
authors.initials: S
authors.lastname: Qi
authors.affiliation: College of Science, China Agricultural University, Beijing 100193, China.
authors.forename: Lizhen
authors.initials: L
authors.lastname: Zhu
authors.affiliation: College of Science, China Agricultural University, Beijing 100193, China. Electronic address: wangchengju@cau.edu.cn.
authors.forename: Chengju
authors.initials: C
authors.lastname: Wang
authors.affiliation: Institute of Quality Standards & Testing Technology for Agro-Products, Key Laboratory of Agro-product Quality and Safety, Chinese Academy of Agricultural Sciences, Key Laboratory of Agri-food Quality and Safety, Ministry of Agriculture, Beijing 100081, China. Electronic address: qiujing@caas.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Qiu
mesh_terms: D000818:Animals; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D011078:Polychlorinated Biphenyls / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D013237:Stereoisomerism; D014874:Water Pollutants, Chemical / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D015027:Zebrafish / Q000235:genetics / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D014874:Water Pollutants, Chemical; D029961:Zebrafish Proteins; D008315:Malondialdehyde; C032903:2,3,3',4',6-pentachlorobiphenyl; D011078:Polychlorinated Biphenyls
keywords: Bioconcentration; Oxidative stress; PCB91; Zebrafish