title: Iodine-impregnated incision drape and bacterial recolonization in simulated total knee arthroplasty.
abstract: Background and purpose - Iodine-impregnated incision drapes (IIIDs) are used to prevent surgical site infection (SSI). However, there is some evidence to suggest a potential increase in SSI risk as a result of IIID use, possibly from promotion of skin recolonization. A greater number of viable bacteria in the surgical field of an arthroplasty, and surgery in general, may increase the infection risk. We investigated whether IIID use increases bacterial recolonization compared to no drape use under conditions of simulated total knee arthroplasty (TKA). Methods - 20 patients scheduled for TKA were recruited. Each patient had 1 knee randomized for draping with IIID, while the contralateral knee was left bare. The patients thus served as their own control. The operating room conditions and perioperative procedures of a TKA were simulated. Cylinder samples were collected from the skin of each knee prior to disinfection, and again on 2 occasions after skin preparation-75 min apart. Quantities of bacteria were estimated using a spread plate technique under aerobic conditions. Results - We found similar quantities of bacteria on the intervention and control knees immediately after skin disinfection and after 75 min of simulated surgery. These quantities had not increased at the end of surgery when compared to baseline, so no recolonization was detected on the draped knees or on the bare knees. Interpretation - The use of IIIDs did not increase bacterial recolonization in simulated TKA. This study does not support the hypothesis that IIIDs promote bacterial recolonization and postoperative infection risk.
authors.affiliation: a Department of Orthopaedic Surgery and Traumatology ;|c Institute of Clinical Research, Faculty of Health Sciences, University of Southern Denmark , Odense , Denmark.
authors.forename: Nikolaj
authors.initials: N
authors.lastname: Milandt
authors.affiliation: a Department of Orthopaedic Surgery and Traumatology ;|c Institute of Clinical Research, Faculty of Health Sciences, University of Southern Denmark , Odense , Denmark.
authors.forename: Tine
authors.initials: T
authors.lastname: Nymark
authors.affiliation: b Department of Clinical Microbiology , Odense University Hospital ;|c Institute of Clinical Research, Faculty of Health Sciences, University of Southern Denmark , Odense , Denmark.
authors.forename: Hans
authors.initials: H
authors.lastname: Jørn Kolmos
authors.affiliation: a Department of Orthopaedic Surgery and Traumatology ;|c Institute of Clinical Research, Faculty of Health Sciences, University of Southern Denmark , Odense , Denmark.
authors.forename: Claus
authors.initials: C
authors.lastname: Emmeluth
authors.affiliation: a Department of Orthopaedic Surgery and Traumatology ;|c Institute of Clinical Research, Faculty of Health Sciences, University of Southern Denmark , Odense , Denmark.
authors.forename: Søren
authors.initials: S
authors.lastname: Overgaard
mesh_terms: D000368:Aged; D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D001419:Bacteria / Q000254:growth & development*; D005260:Female; D006801:Humans; D007455:Iodine / Q000494:pharmacology*; D008297:Male; D016544:Patient Simulation; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D012867:Skin / Q000382:microbiology; D058636:Surgical Drapes; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D000891:Anti-Infective Agents, Local; D007455:Iodine