title: Frailty of Obese Children: Evaluation of Plasma Antioxidant Capacity in Pediatric Obesity.
abstract: Background:Obese children are subject to the same chronic oxidative and inflammatory stress, responsible for the onset of all the complications typical of adult age, such as insulin resistance, type 2 diabetes, dyslipidemia and cardiovascular disease.Objectives:Since few studies are reported in prepubertal obese children, we investigated the relationship between oxidative stress, body composition and metabolic pattern in childhood obesity in comparison with adult obese patients.Methods:We enrolled 25 prepubertal children (12 males and 13 females) aged 5-12 years with a mean value of standard deviation of BMI (SDS-BMI)±SEM of 1.96±0.09. We performed oral glucose tolerance test, hormonal and metabolic evaluation, bioimpedentiometry, evaluation of total antioxidant capacity using spectroscopical method using a radical cation, 2,2I- azinobis(3-ethylbenzothiazoline-6 sulphonate) (ABTS), as indicator of radical formation, with a latency time (LAG) proportional to antioxidant in the sample.Results:LAG values significantly correlate with % fat mass, waist circumference and waist/hip ratio. However mean LAG values were significantly lower than in obese adults.Conclusions:We suggest that children are more susceptible to oxidative stress than adults, possibly to incomplete development of antioxidant system. Prognostic and therapeutical implications need to be further investigated.
authors.affiliation: Department of Medical Sciences, Division of Endocrinology, Catholic University of The Sacred Heart, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Leo
authors.affiliation: Institute of Pediatrics, Catholic University of The Sacred Heart, Rome, Italy.
authors.forename: A N
authors.initials: AN
authors.lastname: Rossodivita
authors.affiliation: Department of Medical Sciences, Division of Endocrinology, Catholic University of The Sacred Heart, Rome, Italy.
authors.forename: C D
authors.initials: CD
authors.lastname: Segni
authors.affiliation: Department of Medical Sciences, Division of Endocrinology, Catholic University of The Sacred Heart, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Raimondo
authors.affiliation: Department of Laboratory Medicine, Dietetic Service, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Canichella
authors.affiliation: Institute of Biochemistry and Clinical Biochemistry, Catholic University of The Sacred Heart, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Silvestrini
authors.affiliation: Department of Laboratory Medicine, Dietetic Service, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: G A D
authors.initials: GA
authors.lastname: Miggiano
authors.affiliation: Institute of Biochemistry and Clinical Biochemistry, Catholic University of The Sacred Heart, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Meucci
authors.affiliation: Department of Medical Sciences, Division of Endocrinology, Catholic University of The Sacred Heart, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Mancini
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood* / Q000473:pathology; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D000975:Antioxidants