title: Genomic Regions Associated with Sheep Resistance to Gastrointestinal Nematodes.
abstract: Genetic markers for sheep resistance to gastrointestinal parasites have long been sought by the livestock industry as a way to select more resistant individuals and to help farmers reduce parasite transmission by identifying and removing high egg shedders from the flock. Polymorphisms related to the major histocompatibility complex and interferon (IFN)-γ genes have been the most frequently reported markers associated with infection. Recently, a new picture is emerging from genome-wide studies, showing that not only immune mechanisms are important determinants of host resistance but that gastrointestinal mucus production and hemostasis pathways may also play a role.
authors.affiliation: Embrapa, Brasília, DF, Brazil. Electronic address: magda.benavides@embrapa.br.
authors.forename: Magda Vieira
authors.initials: MV
authors.lastname: Benavides
authors.affiliation: Recombinetics, Saint Paul, MN, USA.
authors.forename: Tad S
authors.initials: TS
authors.lastname: Sonstegard
authors.affiliation: Animal Genomics and Improvement Laboratory, US Department of Agriculture (USDA)/Agricultural Research Service (ARS) Beltsville Agricultural Research Center, Beltsville, MD, USA.
authors.forename: Curtis
authors.initials: C
authors.lastname: Van Tassell
mesh_terms: D000818:Animals; D001947:Breeding; D060467:Disease Resistance / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D016678:Genome / Q000235:genetics*; D006790:Host-Parasite Interactions / Q000235:genetics*; D007411:Intestinal Diseases, Parasitic / Q000235:genetics / Q000662:veterinary*; D009348:Nematoda / Q000502:physiology; D009349:Nematode Infections / Q000235:genetics / Q000662:veterinary*; D012756:Sheep / Q000235:genetics; D012757:Sheep Diseases / Q000235:genetics*
chemical_list: D005819:Genetic Markers