title: Consumption of the Soluble Dietary Fibre Complex PolyGlycopleX(®) Reduces Glycaemia and Increases Satiety of a Standard Meal Postprandially.
abstract: The effect of consumption of PolyGlycopleX(®) (PGX(®)) was compared to wheat dextrin (WD) in combination with a standard meal, on postprandial satiety and glycaemia in a double-blind, randomised crossover trial, of 14 healthy subjects trained as a satiety panel. At each of six two-hour satiety sessions, subjects consumed one of three different test meals on two separate occasions. The test meals were: a standard meal plus 5 g PGX; a standard meal plus 4.5 g of PGX as softgels; and a standard meal plus 5 g of WD. Subjects recorded fullness using a labelled magnitude scale at 0, 15, 30, 45, 60, 90, and 120 min and the total area under the curve (AUC), mean fullness vs. time was calculated. The meals with PGX (in granular and softgel form) gave higher satiety (AUC) (477 ± 121 and 454 ± 242 cm·min), than the meal with WD (215 ± 261 cm·min) (p < 0.001). Subjects had blood glucose levels measured after the meals with PGX (granules) and WD. Glucose response (AUC) was significantly lower (p < 0.001) after the PGX meal than for the WD meal.  The high viscosity reported for PGX is a likely mechanism behind the significant satiety and blood glucose modulating effects observed in this study.
authors.affiliation: School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia 6845, Australia. v.solah@curtin.edu.au.
authors.forename: Vicky A
authors.initials: VA
authors.lastname: Solah
authors.affiliation: School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia 6845, Australia. babette.omara-wallace@postgrad.curtin.edu.au.
authors.forename: Babette
authors.initials: B
authors.lastname: O'Mara-Wallace
authors.affiliation: Flinders Centre for Innovation in Cancer, School of Medicine, Flinders University, Adelaide 5001, Australia. rosie.meng@flinders.edu.au.
authors.forename: Xingqiong
authors.initials: X
authors.lastname: Meng
authors.affiliation: Factors Group R &amp; D, Burnaby, BC V3N 4S9, Canada. rgahler@naturalfactors.com.
authors.forename: Roland J
authors.initials: RJ
authors.lastname: Gahler
authors.affiliation: School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia 6845, Australia. d.kerr@curtin.edu.au.
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Kerr
authors.affiliation: School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia 6845, Australia. T.P.James@curtin.edu.au.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: James
authors.affiliation: School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia 6845, Australia. h.fenton@curtin.edu.au.
authors.forename: Haelee K
authors.initials: HK
authors.lastname: Fenton
authors.affiliation: School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia 6845, Australia. s.johnson@curtin.edu.au.
authors.forename: Stuart K
authors.initials: SK
authors.lastname: Johnson
authors.affiliation: School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia 6845, Australia. simonwood@shaw.ca.|InovoBiologic Inc., Calgary, AB Y2N 4Y7, Canada. simonwood@shaw.ca.|Food, Nutrition and Health Program, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. simonwood@shaw.ca.
authors.forename: Simon
authors.initials: S
authors.lastname: Wood
mesh_terms: D000328:Adult; D000464:Alginates / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D019540:Area Under Curve; D001786:Blood Glucose / Q000187:drug effects* / Q000502:physiology; D018592:Cross-Over Studies; D003912:Dextrins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D004043:Dietary Fiber / Q000008:administration & dosage / Q000494:pharmacology*; D019587:Dietary Supplements; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D019518:Postprandial Period; D012528:Satiety Response / Q000187:drug effects*; D014908:Triticum; D014783:Viscosity; D055815:Young Adult
chemical_list: D000464:Alginates; D001786:Blood Glucose; D003912:Dextrins; D004043:Dietary Fiber; D004338:Drug Combinations; C540519:PolyGlycoplex; D011135:Polysaccharides, Bacterial; D005947:Glucose
keywords: PGX; dextrin; fibre; glycaemia; satiety