title: Epidermal growth factor receptor gene mutation as risk factor for recurrence in patients with surgically resected lung adenocarcinoma: a matched-pair analysis.
abstract: Epidermal growth factor receptor (EGFR) mutation is a robust prognostic factor in patients with lung adenocarcinoma (ADC). However, the role of EGFR mutation status as a recurrence-risk factor remains unknown because the presence of such mutations is associated with other background characteristics. We therefore conducted a matched-pair analysis to compare recurrence-free survival (RFS) in matched cohorts of patients with lung ADC.
  
  
  
  We enrolled 379 patients who underwent surgical resection for lung ADC between 2005 and 2012. We determined the EGFR mutation status of each tumour. Matching their age, gender, smoking history and pathological stage (pStage), we compared RFS between matched cohorts with and without EGFR mutation (n = 86 each).
  
  
  
  The median age was 67 years, there were 39 (45%) men, 39 (45%) ex- or current smokers and pStage I: 71 (83%), II: 5 (6%), III: 8 (9%), IV: 2 (2%) in each group. The 3- and 5-year RFS rates in patients with mutant and wild-type EGFR were 85 and 78%, and 74 and 60%, respectively, with significant differences between the groups (P = 0.040). Multivariate analysis identified vascular invasion and lymphatic permeation, but not EGFR mutation status, as independent risk factors for recurrence.
  
  
  
  EGFR-gene mutation might be a favourable recurrence-risk factor in patients with surgically resected lung ADC, but further studies in larger cohorts are needed to verify this hypothesis.
authors.affiliation: Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan yukimatsumura1980@gmail.com.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Matsumura
authors.affiliation: Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Owada
authors.affiliation: Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Yamaura
authors.affiliation: Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Muto
authors.affiliation: Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Osugi
authors.affiliation: Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Hoshino
authors.affiliation: Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan.
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Higuchi
authors.affiliation: Department of Epidemiology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ohira
authors.affiliation: Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan.
authors.forename: Mitsukazu
authors.initials: M
authors.lastname: Gotoh
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000601:surgery*; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D018773:Genes, erbB-1 / Q000235:genetics*; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008175:Lung Neoplasms / Q000235:genetics / Q000601:surgery*; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009154:Mutation; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000235:genetics*; D011013:Pneumonectomy / Q000379:methods*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D004273:DNA, Neoplasm
keywords: Epidermal growth factor receptor; Lung adenocarcinoma; Matched-pair analysis; Recurrence factor