title: The Efficacy of Zinc Administration in the Treatment of Primary Dysmenorrhea.
abstract: OBJECTIVE
  Dysmenorrhea is a common complaint in women. Primary dysmenorrhea is defined as painful menstruation in the absence of pelvic disease and is caused by uterine contractions caused by prostaglandins released from the endometrium. Conventional treatments include nonsteroidal anti-inflammatory drugs and oral contraceptives. We sought to evaluate the efficacy of zinc supplementation in the treatment of primary dysmenorrhea. .
  
  
  METHODS
  Two-hundred participants with primary dysmenorrhea were randomized into one of two groups. The intervention group received zinc and mefenamic acid, and the control group received mefenamic acid and a placebo drug. After three months of treatment, changes in the incidence of dysmenorrhea and the degree of pain were measured in both groups. .
  
  
  RESULTS
  The mean pain score before administration of zinc and mefenamic acid in the intervention group was 5.3±1.8 and after treatment was 1.2±1.9 (p < 0.001). In the control group, the mean pain score before administration of mefenamic acid and placebo was 5.8±2.1 and after treatment was 2.9±2.6 (p < 0.001). The difference in pain levels before and after treatment in the intervention group was 4.1±2.8, and in the control group was 2.9±1.7 (p > 0.050). We also found that 64% of case group and 33% of the control group did not experience dysmenorrhea after treatment (p < 0.001). .
  
  
  CONCLUSIONS
  The use of a zinc supplement in combination with mefenamic acid was superior in reducing primary dysmenorrhea compared to mefenamic acid alone.
authors.affiliation: Department of Obstetrics and Gynecology, Pregnancy Health Research Center, Ali Ibn Abi Taleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Batool
authors.initials: B
authors.lastname: Teimoori
authors.affiliation: Department of Obstetrics and Gynecology, Pregnancy Health Research Center, Ali Ibn Abi Taleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Marzieh
authors.initials: M
authors.lastname: Ghasemi
authors.affiliation: General practitioner, Zahedan, Iran.
authors.forename: Zeinab Sadat Amir
authors.initials: ZS
authors.lastname: Hoseini
authors.affiliation: Department of Obstetrics and Gynecology, Pregnancy Health Research Center, Ali Ibn Abi Taleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Razavi
keywords: Dysmenorrhea; Zinc