title: Biodiversity of Intestinal Lactic Acid Bacteria in the Healthy Population.
abstract: The complex ecosystem of the gastrointestinal tract involves tight interrelations among host cells, diet, and billions of microbes, both beneficial and opportunistic pathogens. In spite of advanced genomic, metagenomic, and metabonomic approaches, knowledge is still quite limited regarding the biodiversity of beneficial microbiota, including Lactobacillus spp., and its impact on the main biomarkers of general health. In this paper, Lactobacillus biodiversity is demonstrated through its taxonomy, function, and host-microbial interactions. Its prevalence, composition, abundance, intertwined metabolic properties, and relation to host age, genotype, and socioeconomic factors are reviewed based on the literature and original research experience. The species richness, e.g., the biodiversity of gut microbiota, provides the host with a variety of metabolically active species and strains that predict their response for different health conditions and extrinsic interventions. Metabolically active and safe Lactobacillus species and specific strains with particular functional properties increase the biodiversity of the whole intestinal microbiota. The elaborated principles for effective application of probiotics are discussed, aimed at regulating the composition of microbiota simultaneously with blood and urine biomarkers at the borderline of normality. This approach targets the impact of probiotic strains to maintenance of health with anti-infectious, cardiovascular, and metabolic support.
authors.affiliation: Institute of Biomedicine and Translational Medicine, University of Tartu, Europe, Estonia. marika.mikelsaar@ut.ee.
authors.forename: Marika
authors.initials: M
authors.lastname: Mikelsaar
authors.affiliation: Institute of Biomedicine and Translational Medicine, University of Tartu, Europe, Estonia.
authors.forename: Epp
authors.initials: E
authors.lastname: Sepp
authors.affiliation: Institute of Biomedicine and Translational Medicine, University of Tartu, Europe, Estonia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Štšepetova
authors.affiliation: Bio-Competence Centre of Healthy Dairy Products, Europe, Estonia.
authors.forename: Epp
authors.initials: E
authors.lastname: Songisepp
authors.affiliation: Institute of Biomedicine and Translational Medicine, University of Tartu, Europe, Estonia.
authors.forename: Reet
authors.initials: R
authors.lastname: Mändar
mesh_terms: D044822:Biodiversity; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D007778:Lactobacillus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D019936:Probiotics / Q000032:analysis
chemical_list: D019344:Lactic Acid
keywords: Functional properties; Health maintenance; Human; Lactobacilli; Metabolite; Probiotic elaboration; Species diversity; Taxonomy