title: Effect of a New Antioxidant Enoxifol on Platelet Aggregation and Blood Rheological Properties in Rats with Experimental Diabetes Mellitus.
abstract: Effect of a new antioxidant enoxifol exhibiting antiplatelet activity in vitro and in vivo on hemostasis parameters was assessed in laboratory rats with experimental diabetes mellitus. Gliclazide, a hypoglycemic agent with antiplatelet properties, and pentoxifylline, a preparation improving blood rheology, were used as the reference drugs. Enoxifol produced a pronounced inhibitory effect on platelet aggregation in rats with experimental diabetes comparable to the effect of gliclazide and decreased blood viscosity thus demonstrating a significant effect comparable to that of pentoxifylline. In view of the fact that oxidative stress is a pathogenetic components of vascular complications in diabetes, it can be assumed that improvement of hemostasis parameters under the effect of enoxifol is determined by its antiplatelet and antioxidant activities.
authors.affiliation: Department of Pharmacology, Volgograd State Medical University, Volgograd, Russia. aidakucheryavenko@yandex.ru.
authors.forename: A F
authors.initials: AF
authors.lastname: Kucheryavenko
authors.affiliation: Department of Pharmacology, Volgograd State Medical University, Volgograd, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.affiliation: Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Anisimova
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001562:Benzimidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose; D001809:Blood Viscosity / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005907:Gliclazide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D001562:Benzimidazoles; D001786:Blood Glucose; D007004:Hypoglycemic Agents; C000589732:enoxifol; D005907:Gliclazide
keywords: antioxidant activity; blood viscosity; enoxifol; platelet aggregation