title: Marathon performance but not BMI affects post-marathon pro-inflammatory and cartilage biomarkers.
abstract: We tested the hypothesis that changes in serum cartilage oligomeric matrix protein (COMP), tumour necrosis factor α (TNF-α), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) concentration after regular endurance training and running a marathon race depend on body mass index (BMI) and/or on marathon performance. Blood samples were collected from 45 runners of varying BMI and running experience before and after a 10-week marathon training programme and before, immediately and 24 h after a marathon race. Serum biomarker concentrations, BMI and marathon finishing time were measured. The mean (95% confidence interval (CI)) changes from before to immediately after the marathon were COMP: 4.09 U/L (3.39-4.79 U/L); TNF-α: -1.17 mg/L (-2.58 to 0.25 mg/L); IL-6: 12.0 pg/mL (11.4-12.5 pg/mL); and hsCRP: -0.08 pg/mL (-0.14 to -0.3 pg/mL). The mean (95% CI) changes from immediately after to 24 h after the marathon were COMP: 0.35 U/L (-0.88 to 1.57 U/L); TNF-α: -0.43 mg/L (-0.99 to 0.13 mg/L); IL-6: -9.9 pg/mL (-10.5 to -9.4 pg/mL); and hsCRP: 1.52 pg/mL (1.25-1.79 pg/mL). BMI did not affect changes in biomarker concentrations. Differences in marathon finishing time explained 32% of variability in changes in serum hsCRP and 28% of variability in changes in serum COMP during the 24 h recovery after the marathon race (P < 0.001). Slower marathon finishing time but not a higher BMI modulates increases in pro-inflammatory markers or cartilage markers following a marathon race.
authors.affiliation: a Clinic for Orthopaedics and Traumatology , University Hospital Basel , Basel , Switzerland.|b Department of Biomedical Engineering , University of Basel , Basel , Switzerland.
authors.forename: Annegret
authors.initials: A
authors.lastname: Mündermann
authors.affiliation: b Department of Biomedical Engineering , University of Basel , Basel , Switzerland.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Geurts
authors.affiliation: a Clinic for Orthopaedics and Traumatology , University Hospital Basel , Basel , Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hügle
authors.affiliation: c Medizinische Klinik und Poliklinik 1, Campus Grosshadern , Ludwig-Maximilians-Universität München , Munich , Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Nickel
authors.affiliation: d Department of Sport, Exercise and Health , University of Basel , Basel , Switzerland.
authors.forename: Arno
authors.initials: A
authors.lastname: Schmidt-Trucksäss
authors.affiliation: e Department of Prevention and Sports Medicine , Technische Universität München , Munich , Germany.|f Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), partner site Munich Heart Alliance , Munich , Germany.|g Else Kröner-Fresenius-Zentrum, Klinikum rechts der Isar , Technische Universität München , Munich , Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Halle
authors.affiliation: d Department of Sport, Exercise and Health , University of Basel , Basel , Switzerland.|e Department of Prevention and Sports Medicine , Technische Universität München , Munich , Germany.
authors.forename: Henner
authors.initials: H
authors.lastname: Hanssen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002356:Cartilage / Q000378:metabolism*; D064236:Cartilage Oligomeric Matrix Protein; D006801:Humans; D007249:Inflammation / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D010807:Physical Endurance / Q000502:physiology*; D012420:Running / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D064236:Cartilage Oligomeric Matrix Protein; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; C577553:TSP5 protein, human
keywords: Cartilage biomarkers; marathon running; obesity; pro-inflammatory markers; tissue metabolism