title: The effect of age on outcome after intra-arterial treatment in acute ischemic stroke: a MR CLEAN pretrial study.
abstract: BACKGROUND
  In recent randomized controlled trials (RCTs) intra-arterial treatment (IAT) has been proven effective and safe for patients with acute ischemic stroke (AIS). So far, there seemed to be no interaction between older age (>80) and main treatment effect. We studied the association of older age with outcome and adverse events after IAT in a cohort of intra arterially treated patients.
  
  
  RESULTS
  Data from all AIS patients with proven proximal anterior circulation cerebral artery occlusion who were intra arterially treated between 2002 until the start of the MR CLEAN trial were studied retrospectively. Duration of the procedure, recanalization (Thrombolysis In Cerebral Infarction score (TICI)), early neurological recovery (i.e. decrease on NIHSS of ≥ 8 points) after one week or at discharge, good functional outcome at discharge by modified Rankin Scale (mRS ≤ 2) and the occurrence of neurological and non-neurological adverse events were assessed and the association with age was investigated. In total 315 patients met our inclusion criteria. Median age was 63 years (range 22-93) and 17 patients (5.4%) were over 80. Age was inversely associated with good functional outcome (adjusted Odds Ratio (aOR) 0.80, 95% CI: 0.66-0.98) for every 10 years increase of age. Age was not associated with longer duration of the procedure, lower recanalization rate or less early neurological recovery. The risk of all adverse events (aOR 1.27; 95% CI: 1.08-1.50) and non-neurological adverse events (aOR 1.34; 95% CI: 1.11-1.61) increased, but that of peri-procedural adverse events (aOR 0.79; 95% CI: 0.66-0.94) decreased with age.
  
  
  CONCLUSIONS
  Higher age is inversely associated with good functional outcome after IAT in patients with AIS. However, treatment related adverse events are not related to age. These findings may help decision making when considering treatment of older patients with AIS.
authors.affiliation: Department of Neurology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Oxfordlaan 10, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands. debbie.beumer@mumc.nl.|Department of Neurology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. debbie.beumer@mumc.nl.
authors.forename: Debbie
authors.initials: D
authors.lastname: Beumer
authors.affiliation: Department of Neurology, MC Haaglanden, The Hague, The Netherlands.
authors.forename: Anouk D
authors.initials: AD
authors.lastname: Rozeman
authors.affiliation: Department of Radiology, MC Haaglanden, The Hague, The Netherlands.
authors.forename: Geert J
authors.initials: GJ
authors.lastname: Lycklama À Nijeholt
authors.affiliation: Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Brouwer
authors.affiliation: Department of Radiology, Nijmegen University Medical Center, Nijmegen, The Netherlands.
authors.forename: Sjoerd F M
authors.initials: SF
authors.lastname: Jenniskens
authors.affiliation: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, Utrecht University Medical Center, Utrecht, The Netherlands.|Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Ale
authors.initials: A
authors.lastname: Algra
authors.affiliation: Department of Neurology, MC Haaglanden, The Hague, The Netherlands.
authors.forename: Jelis
authors.initials: J
authors.lastname: Boiten
authors.affiliation: Department of Neurology, St. Antonius hospital, Nieuwegein, The Netherlands.
authors.forename: Wouter
authors.initials: W
authors.lastname: Schonewille
authors.affiliation: Department of Neurology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Oxfordlaan 10, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: van Oostenbrugge
authors.affiliation: Department of Neurology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Diederik W J
authors.initials: DW
authors.lastname: Dippel
authors.affiliation: Department of Radiology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Wim H
authors.initials: WH
authors.lastname: van Zwam
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D020521:Stroke / Q000150:complications / Q000188:drug therapy*; D013997:Time Factors; D055815:Young Adult
chemical_list: D005343:Fibrinolytic Agents
keywords: Acute ischemic stroke; Intra-arterial treatment; Older age