title: Functional Significance and Predictive Value of MicroRNAs in Pediatric Obesity: Tiny Molecules with Huge Impact?
abstract: Obesity is a major health concern. While some children develop comorbidities such as insulin resistance and low-grade systemic inflammation upon weight gain, others stay metabolically healthy. There is an urgent need for clinically relevant markers with prognostic value related to disease development and intervention success. MicroRNAs (miRNAs) are established biomarkers for several disease states. Herein, we give a brief overview of miRNA biogenesis and function and the potential role of circulating miRNA in the context of pediatric obesity.
authors.affiliation: Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.
authors.forename: Pamela
authors.initials: P
authors.lastname: Fischer-Posovszky
authors.forename: Julian
authors.initials: J
authors.lastname: Roos
authors.forename: Primoz
authors.initials: P
authors.lastname: Kotnik
authors.forename: Tadej
authors.initials: T
authors.lastname: Battelino
authors.forename: Elena
authors.initials: E
authors.lastname: Inzaghi
authors.forename: Valerio
authors.initials: V
authors.lastname: Nobili
authors.forename: Stefano
authors.initials: S
authors.lastname: Cianfarani
authors.forename: Martin
authors.initials: M
authors.lastname: Wabitsch
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs