title: NSAID Use after Bariatric Surgery: a Randomized Controlled Intervention Study.
abstract: Use of nonsteroidal anti-inflammatory drugs (NSAIDs) should be avoided in bariatric surgery patients. If use of an NSAID is inevitable, a proton pump inhibitor (PPI) should also be used.
  
  
  
  To determine the effect of an, compared to care-as-usual, additional intervention to reduce NSAID use in patients who underwent bariatric surgery, and to determine the use of PPIs in patients who use NSAIDs after bariatric surgery.
  
  
  
  A randomized controlled intervention study in patients after bariatric surgery. Patients were randomized to an intervention or a control group. The intervention consisted of sending a letter to patients and their general practitioners on the risks of use of NSAIDs after bariatric surgery and the importance of avoiding NSAID use. The control group received care-as-usual. Dispensing data of NSAIDs and PPIs were collected from patients' pharmacies: from a period of 6 months before and from 3 until 9 months after the intervention.
  
  
  
  Two hundred forty-eight patients were included (intervention group: 124; control group: 124). The number of users of NSAIDs decreased from 22 to 18 % in the intervention group and increased from 20 to 21 % in the control group (NS). The use of a PPI with an NSAID rose from 52 to 55 % in the intervention group, and from 52 to 69 % in the control group (NS).
  
  
  
  Informing patients and their general practitioners by letter, in addition to care-as-usual, is not an effective intervention to reduce the use of NSAIDs after bariatric surgery (trial number NTR3665).
authors.affiliation: Department of Clinical Pharmacy and Clinical Pharmacology, Medical Centre Leeuwarden, Leeuwarden, Netherlands. j.p.yska@znb.nl.
authors.forename: Jan Peter
authors.initials: JP
authors.lastname: Yska
authors.affiliation: Department of Clinical Pharmacy and Clinical Pharmacology, Medical Centre Leeuwarden, Leeuwarden, Netherlands.
authors.forename: Sanneke
authors.initials: S
authors.lastname: Gertsen
authors.affiliation: Department of Clinical Pharmacy and Clinical Pharmacology, Medical Centre Leeuwarden, Leeuwarden, Netherlands.
authors.forename: Gerbrich
authors.initials: G
authors.lastname: Flapper
authors.affiliation: Department of Surgery, Medical Centre Leeuwarden, Leeuwarden, Netherlands.
authors.forename: Marloes
authors.initials: M
authors.lastname: Emous
authors.affiliation: Department of Pharmacotherapy, -Epidemiology and Economics, Department of Pharmacy, University of Groningen, Groningen, Netherlands.|Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
authors.forename: Bob
authors.initials: B
authors.lastname: Wilffert
authors.affiliation: Department of Clinical Pharmacy and Clinical Pharmacology, Medical Centre Leeuwarden, Leeuwarden, Netherlands.|Department of Pharmacotherapy, -Epidemiology and Economics, Department of Pharmacy, University of Groningen, Groningen, Netherlands.
authors.forename: Eric N
authors.initials: EN
authors.lastname: van Roon
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D050110:Bariatric Surgery / Q000009:adverse effects / Q000534:rehabilitation; D015897:Comorbidity; D000075202:Contraindications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000601:surgery*; D010353:Patient Education as Topic / Q000379:methods; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D054328:Proton Pump Inhibitors
keywords: Bariatric surgery; Drug safety; Intervention; NSAID; Proton pump inhibitor