title: Head of the Class: OLIG2 and Glioblastoma Phenotype.
abstract: Genomic mapping has driven the classification of glioblastoma into distinct molecular subclasses, but mechanisms that regulate tumor subclass phenotypes are only now emerging. In this issue of Cancer Cell, Lu et al. describe a phenotypic switch from PDGFRA-enriched "proneural" to EGFR-enriched "classical" features in glioblastoma upon ablation of Olig2.
authors.affiliation: Department of Cancer Biology, Vanderbilt University School of Medicine, 761B Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232-6840, USA.
authors.forename: Nalin
authors.initials: N
authors.lastname: Leelatian
authors.affiliation: Department of Cancer Biology, Vanderbilt University School of Medicine, 761B Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232-6840, USA; Department of Neurological Surgery, Vanderbilt University School of Medicine, 761B Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232-6840, USA. Electronic address: rebecca.ihrie@vanderbilt.edu.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Ihrie
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D010641:Phenotype; D014157:Transcription Factors / Q000235:genetics
chemical_list: D014157:Transcription Factors