title: Association of Herpes Zoster and Type 1 Diabetes Mellitus.
abstract: The purpose of our study was to determine the association of type 1 diabetes mellitus (T1DM) and the risk of herpes zoster (HZ).
  
  
  
  In this cohort study, we selected 4736 patients with T1DM registered in the Catastrophic Illness Patient Database who received insulin therapy before 2003 and 18944 participants without DM who were selected by frequency matched based on sex and age. Cox proportional hazard regression analysis was used to measure the hazard ratios (HRs) of HZ in the T1DM group compared with that in the non-T1DM group.
  
  
  
  Cox proportional hazard regression analysis showed that the adjusted HR of HZ was 2.38 times higher for patients in the T1DM group (95% CI = 1.77-3.19) than for those in the non-T1DM group. According to diabetes severity, mild and serious T1DM patients were associated with a higher risk of HZ (adjusted HR = 2.26, 95% CI = 1.67-3.05; and adjusted HR = 5.08, 95% CI = 2.66-9.71, respectively) than subjects without T1DM.
  
  
  
  Patients with T1DM are at a higher risk of HZ than those without T1DM.
authors.affiliation: School of Medicine and Public Health, Chung Shan Medical University, Taichung, Taiwan.|Division of Metabolism & Endocrinology, Changhua Christian Hospital, Changhua, Taiwan.|Nantou Christian Hospital, Nantou, Taiwan.
authors.forename: Hsin-Hung
authors.initials: HH
authors.lastname: Chen
authors.affiliation: School of Medicine, Chung Shan Medical University, Taichung, Taiwan.|Department of Family Medicine, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: I-Ching
authors.initials: IC
authors.lastname: Lin
authors.affiliation: Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.|College of Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Hsuan-Ju
authors.initials: HJ
authors.lastname: Chen
authors.affiliation: Asia University, Taichung, Taiwan.
authors.forename: Su-Yin
authors.initials: SY
authors.lastname: Yeh
authors.affiliation: Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.|Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Kao
mesh_terms: D000328:Adult; D015897:Comorbidity; D003710:Demography; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006562:Herpes Zoster / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D055815:Young Adult