title: Construction and Characterization of a Population-Based Cohort to Study the Association of Anesthesia Exposure with Neurodevelopmental Outcomes.
abstract: Exposure to general anesthesia at an early age has been associated with adverse neurodevelopmental outcomes in both animal and human studies, but some of these studies employed anesthetic agents that are no longer in clinical use. In this manuscript, we describe the methods used to construct a new population-based study cohort to study the association between early anesthetic exposure and subsequent neurodevelopmental outcomes. A birth cohort of all children born in Olmsted County, MN from January 1, 1996 to December 31, 2000 was identified. For each, school enrollment status in the Independent School District (ISD) 535 at age 5 or 6 and all episodes of anesthetic exposure before age 3 were identified. A study cohort was created by matching children enrolled in ISD 535 based on the propensity of receiving general anesthesia. Three analyses were performed to characterize the study cohort by comparing the birth and parental information, comorbidities, and socioeconomic status. The first analysis compared the characteristics of birth cohort children who were and were not enrolled in ISD 535. The second analysis evaluated the success of the propensity matching schemes in creating groups of children that were similar in measured characteristics except for anesthesia exposure. The third analysis compared the characteristics of children with anesthesia exposures who were and were not included in the final cohort based on propensity matching. Results of these analyses demonstrate only slight differences among the comparison groups, and therefore these are unlikely to compromise our future analysis of anesthetic exposure and neurodevelopmental outcomes.
authors.affiliation: Mayo Graduate School, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Danqing
authors.initials: D
authors.lastname: Hu
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Randall P
authors.initials: RP
authors.lastname: Flick
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Gleich
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Maura M
authors.initials: MM
authors.lastname: Scanlon
authors.affiliation: Department of Psychology, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Zaccariello
authors.affiliation: Department of Psychology, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Colligan
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Slavica K
authors.initials: SK
authors.lastname: Katusic
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Darrell R
authors.initials: DR
authors.lastname: Schroeder
authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Hanson
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Shonie L
authors.initials: SL
authors.lastname: Buenvenida
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Wilder
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: Juraj
authors.initials: J
authors.lastname: Sprung
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, United States of America.
authors.forename: David O
authors.initials: DO
authors.lastname: Warner
mesh_terms: D000768:Anesthesia, General / Q000009:adverse effects*; D000777:Anesthetics / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000139:chemically induced / Q000175:diagnosis; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008910:Minnesota; D019636:Neurodegenerative Diseases / Q000139:chemically induced / Q000175:diagnosis; D018579:Patient Selection; D011379:Prognosis; D012574:Schools; D012923:Social Class; D013334:Students
chemical_list: D000777:Anesthetics