title: Conditioning pain stimulation does not affect itch induced by intra-epidermal histamine pricks but aggravates neurogenic inflammation in healthy volunteers.
abstract: This study investigated whether itch induced by intra-epidermal histamine is subjected to modulation by a standardized conditioned pain modulation (CPM) paradigm in 24 healthy volunteers. CPM was induced by computer-controlled cuff pressure algometry and histamine was introduced to the volar forearm by skin prick test punctures. Moreover, neurogenic inflammation and wheal reactions induced by histamine and autonomic nervous system responses (heart rate variability and skin conductance) were monitored. CPM did not modulate the intensity of histamine-induced itch suggesting that pruriceptive signaling is not inhibited by pain-recruited endogenous modulation, however, CPM was found to aggravate histamine-induced neurogenic inflammation, likely facilitated by efferent sympathetic fibers.
authors.affiliation: a SMI, Department of Health Science and Technology , Aalborg University , Aalborg , Denmark ;
authors.forename: H H
authors.initials: HH
authors.lastname: Andersen
authors.affiliation: a SMI, Department of Health Science and Technology , Aalborg University , Aalborg , Denmark ;|b Clinical Development Department , Clinical Department Center, Asahi Kasei Pharma Corporation , Tokyo , Japan ;
authors.forename: Y
authors.initials: Y
authors.lastname: Imai
authors.affiliation: a SMI, Department of Health Science and Technology , Aalborg University , Aalborg , Denmark ;
authors.forename: K K
authors.initials: KK
authors.lastname: Petersen
authors.affiliation: c Department of Psychology , The Ohio State University , Columbus, Ohio , USA ;|d Section for Translational Psychobiology in Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry , Centre for Psychosocial Medicine, University of Heidelberg , Heidelberg , Germany ;
authors.forename: J
authors.initials: J
authors.lastname: Koenig
authors.affiliation: e The Allergy Clinic, Copenhagen University Hospital , Gentofte , Copenhagen , Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Elberling
authors.affiliation: a SMI, Department of Health Science and Technology , Aalborg University , Aalborg , Denmark ;
authors.forename: L
authors.initials: L
authors.lastname: Arendt-Nielsen
mesh_terms: D000328:Adult; D005260:Female; D005712:Galvanic Skin Response / Q000187:drug effects; D064368:Healthy Volunteers; D006339:Heart Rate / Q000187:drug effects; D006632:Histamine / Q000009:adverse effects*; D017442:Histamine Agonists / Q000009:adverse effects*; D006801:Humans; D008297:Male; D020078:Neurogenic Inflammation / Q000139:chemically induced*; D010146:Pain / Q000503:physiopathology*; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology; D011537:Pruritus / Q000139:chemically induced*; D012867:Skin / Q000294:innervation; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D017442:Histamine Agonists; D006632:Histamine
keywords: Itch; conditioned pain modulation; cuff algometry; heart rate variability; histamine; neurogenic inflammation; skin conductance