title: sTREM-1, sIL-2Rα, and IL-6, but not sCD163, might predict sepsis in polytrauma patients: a prospective cohort study.
abstract: BACKGROUND
  To investigate whether sTREM-1, sIL-2Rα, sCD163, and IL-6 predict septic complications following polytrauma. Prospective observational study in a university hospital intensive care unit.
  
  
  METHODS
  Blood samples were drawn on admission, 24 and 48 h after the injury from 64 adult polytrauma patients. The occurence of infectious complications was investigated. The sepsis-free rates for the multiple trauma patients were considered as end points in the Kaplan-Meier plot analysis.
  
  
  RESULTS
  Upon admission, sIL-2Rα mean values were higher in the T group compared to the T&S patients (1789 ± 1027 pg/mL versus 1280 ± 605 pg/mL, p = 0.02). The initial mean values of sTREM-1, IL-6, and sCD163 did not discriminate between the T and T&S groups patients (p > 0.05). sTREM-1 cutoff was 62 pg/mL: the sepsis-free rates differed significantly between the patients with sTREM-1 concentrations lower and higher than the cutoff (80 versus 48 %, p < 0.01). From the patients with serum sIL-2Rα ≥1593 pg/mL, 86 % did not present sepsis; for sIL-2Rα values in the range 946-1593 pg/mL, the sepsis-free rate was 68 %, while from the patients with sIL-2Rα <945 pg/mL, only 40 % remained sepsis-free (p = 0.05). sCD163 cutoff of 1000 ng/mL did not discriminate between the patients (76 versus 64 %, p = 0.28). For IL-6, the sepsis-free rates differed significantly between the patients with concentrations lower and higher than 400 pg/mL (78 versus 38 %, p < 0.01).
  
  
  CONCLUSIONS
  sTREM-1, sIL-2Rα, and IL-6, but not CD163, may be used as prognostic markers for the occurrence of sepsis in multiple trauma patients.
  
  
  METHODS
  Level II-Diagnostic tests and criteria.
authors.affiliation: Department of Anaesthesia and Intensive Care II, Clinical Emergency County Hospital of Cluj, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, 400006 Clinicilor 3-5, Cluj-Napoca, Romania. sebi_tranca@yahoo.com.
authors.forename: S
authors.initials: S
authors.lastname: Trancă
authors.affiliation: Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: J T
authors.initials: JT
authors.lastname: Oever
authors.affiliation: Surgical Department I, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Ciuce
authors.affiliation: Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Netea
authors.affiliation: Department of Infectious Diseases, "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Slavcovici
authors.affiliation: Department of Anaesthesia and Intensive Care II, Clinical Emergency County Hospital of Cluj, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, 400006 Clinicilor 3-5, Cluj-Napoca, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Petrișor
authors.affiliation: Department of Anaesthesia and Intensive Care II, Clinical Emergency County Hospital of Cluj, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, 400006 Clinicilor 3-5, Cluj-Napoca, Romania.
authors.forename: N
authors.initials: N
authors.lastname: Hagău
mesh_terms: D015703:Antigens, CD / Q000097:blood; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D015331:Cohort Studies; D003422:Critical Care; D005260:Female; D006785:Hospitals, University; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011956:Receptors, Cell Surface / Q000097:blood; D012383:Romania; D018805:Sepsis / Q000097:blood*; D000073871:Triggering Receptor Expressed on Myeloid Cells-1 / Q000097:blood; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015415:Biomarkers; D000098902:CD163 Antigen; D053645:Interleukin-2 Receptor alpha Subunit; D015850:Interleukin-6; D011956:Receptors, Cell Surface; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
keywords: Sepsis; Trauma; sCD163; sIL-2Rα; sTREM-1