title: Finite Element Model for Hydrocephalus and Idiopathic Intracranial Hypertension.
abstract: Hydrocephalus and idiopathic intracranial hypertension (IIH) are neuropathies associated with disturbed cerebrospinal fluid dynamics. Several finite element (FE) brain models were suggested to simulate the pathological changes in hydrocephalus, but with overly simplified assumptions regarding the properties of the brain parenchyma. This study proposes a two-dimensional FE brain model, capable of simulating both hydrocephalus and IIH by incorporating poro-hyperelasticity of the brain and detailed structural information (i.e., sulci).
authors.affiliation: Department of Brain and Cognitive Engineering, Korea University, Anam-dong, Seongbuk-gu, Seoul, 136-713, South Korea. dongjookim@korea.ac.kr.
authors.forename: Dong-Joo
authors.initials: DJ
authors.lastname: Kim
authors.affiliation: Department of Brain and Cognitive Engineering, Korea University, Anam-dong, Seongbuk-gu, Seoul, 136-713, South Korea.
authors.forename: Hakseung
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Brain and Cognitive Engineering, Korea University, Anam-dong, Seongbuk-gu, Seoul, 136-713, South Korea.
authors.forename: Dae-Hyeon
authors.initials: DH
authors.lastname: Park
authors.affiliation: Department of Brain and Cognitive Engineering, Korea University, Anam-dong, Seongbuk-gu, Seoul, 136-713, South Korea.
authors.forename: Hack-Jin
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Neurosurgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Czosnyka
authors.affiliation: Department of Engineering, University of Cambridge, Cambridge, UK.
authors.forename: Michael P F
authors.initials: MP
authors.lastname: Sutcliffe
authors.affiliation: Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
authors.forename: Marek
authors.initials: M
authors.lastname: Czosnyka
mesh_terms: D001929:Brain Edema / Q000209:etiology / Q000503:physiopathology*; D003198:Computer Simulation; D020342:Finite Element Analysis; D006801:Humans; D006849:Hydrocephalus / Q000150:complications / Q000503:physiopathology*; D008959:Models, Neurological; D011559:Pseudotumor Cerebri / Q000150:complications / Q000503:physiopathology*
keywords: Biphasic brain model; Finite element methods; Hydrocephalus; Idiopathic intracranial hypertension