title: Targeting the lncRNA SAMMSON Reveals Metabolic Vulnerability in Melanoma.
abstract: In a recent study, Leucci et al. report a role for the long non-coding RNA SAMMSON in driving mitochondrial function in melanoma. Targeting SAMMSON, the gene of which is frequently co-amplified with MITF, highlights a new cell-type-specific therapeutic vulnerability in melanoma irrespective of BRAF, NRAS, or p53 status.
authors.affiliation: Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Headington, Oxford OX3 7DQ, UK. Electronic address: colin.goding@ludwig.ox.ac.uk.
authors.forename: Colin R
authors.initials: CR
authors.lastname: Goding
mesh_terms: D006801:Humans; D008545:Melanoma / Q000235:genetics; D008928:Mitochondria / Q000235:genetics; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D062085:RNA, Long Noncoding
chemical_list: D062085:RNA, Long Noncoding; D048493:Proto-Oncogene Proteins B-raf