title: Comparisons of the effect of naturally acquired maternal pertussis antibodies and antenatal vaccination induced maternal tetanus antibodies on infant's antibody secreting lymphocyte responses and circulating plasma antibody levels.
abstract: The goal of this study was to explore the effects of trans-placental tetanus toxoid (TT) and pertussis (PT) antibodies on an infant's response to vaccination in the context of antenatal immunization with tetanus but not with pertussis. 38 mothers received a single dose of TT vaccine during pregnancy. Infants received tetanus and pertussis vaccines at 6, 10 and 14 wk of age. TT and PT anti-IgG secretion by infant lymphocytes was measured at 15 wk. Plasma antibodies were measured at 6 wk (pre-vaccination), 15 wk and 1 y of age. Prior to vaccination, TT and PT antibody were detected in 94.6% and 15.2% of infants. At 15 wk anti-TT-IgG and anti-PT-IgG in plasma was increased by 7-9 fold over pre-vaccination levels, while at 1 y plasma anti-TT-IgG was decreased by approximately 5-fold from the peak and had returned to near the pre-vaccination level. At 1 y plasma anti-PT-IgG was decreased by 2-fold 1 yfrom the 15 wk level. However, 89.5% and 82.3% of infants at 1 y had protective levels of anti-TT and anti-PT IgG, respectively. Pre-vaccination plasma IgG levels were associated with lower vaccine-specific IgG secretion by infant lymphocytes at 15 wk (p < 0.10). This apparent inhibition was seen for anti-TT-IgG at both 15 wk (p < 0.05) and t 1 y (p < 0.10) of age. In summary, we report an apparent inhibitory effect of passively derived maternal antibody on an infants' own antibody response to the same vaccine. However, since the cut-off values for protective titers are low, infants had protective antibody levels throughout infancy.
authors.affiliation: a Center for Vaccine Sciences, icddr,b Mohakhali , Dhaka , Bangladesh.
authors.forename: Shaikh Meshbahuddin
authors.initials: SM
authors.lastname: Ahmad
authors.affiliation: a Center for Vaccine Sciences, icddr,b Mohakhali , Dhaka , Bangladesh.
authors.forename: Jahangir
authors.initials: J
authors.lastname: Alam
authors.affiliation: a Center for Vaccine Sciences, icddr,b Mohakhali , Dhaka , Bangladesh.
authors.forename: Nure Alam
authors.initials: NA
authors.lastname: Afsar
authors.affiliation: a Center for Vaccine Sciences, icddr,b Mohakhali , Dhaka , Bangladesh.|b US Department of Agriculture Western Human Nutrition Research Center , Davis , CA , USA.
authors.forename: Nazmul
authors.initials: N
authors.lastname: Huda
authors.affiliation: c Department of Biochemistry and Molecular Biology , University of Dhaka , Dhaka , Bangladesh.
authors.forename: Yearul
authors.initials: Y
authors.lastname: Kabir
authors.affiliation: a Center for Vaccine Sciences, icddr,b Mohakhali , Dhaka , Bangladesh.
authors.forename: Firdausi
authors.initials: F
authors.lastname: Qadri
authors.affiliation: a Center for Vaccine Sciences, icddr,b Mohakhali , Dhaka , Bangladesh.
authors.forename: Rubhana
authors.initials: R
authors.lastname: Raqib
authors.affiliation: b US Department of Agriculture Western Human Nutrition Research Center , Davis , CA , USA.
authors.forename: Charles B
authors.initials: CB
authors.lastname: Stephensen
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000097:blood* / Q000276:immunology*; D001886:Bordetella pertussis / Q000276:immunology*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology; D005260:Female; D018073:Haemophilus Vaccines / Q000276:immunology; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007115:Immunization Schedule; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood / Q000276:immunology; D007223:Infant; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D009035:Mothers; D010567:Pertussis Vaccine / Q000276:immunology*; D011247:Pregnancy; D013745:Tetanus Toxoid / Q000276:immunology*; D014611:Vaccination; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology; D055815:Young Adult
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000907:Antibodies, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; D007074:Immunoglobulin G; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid; D018074:Vaccines, Conjugate; C048844:anti-IgG
keywords: neonate; pertussis; plasma cell; tetanus; trans-placental antibody