title: Novel extrapancreatic effects of incretin.
abstract: The hormonal factors implicated as transmitters of signals from the gut to pancreatic β-cells are referred to as incretins. Gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are incretins. In addition to the insulinotropic effects, we have shown, using the GIP receptor and GLP-1 receptor-deficient mice, that GIP and GLP-1 have direct actions on adipocytes and the kidney, respectively. Because GIP receptors and GLP-1 receptors are differentially expressed in a tissue-specific manner, GIP and GLP-1 have specific physiological activities, and further comprehensive characterization of the extrapancreatic actions of GIP and GLP-1 is anticipated, as dipeptidyl peptidase IV inhibitors activate both GIP and GLP-1 signaling.
authors.affiliation: Department of Endocrinology, Diabetes and Geriatric Medicine Akita University Graduate School of Medicine Akita Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamada
authors.affiliation: Department of Endocrinology, Diabetes and Geriatric Medicine Akita University Graduate School of Medicine Akita Japan.
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tsukiyama
authors.affiliation: Department of Endocrinology, Diabetes and Geriatric Medicine Akita University Graduate School of Medicine Akita Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Sato
authors.affiliation: Department of Endocrinology, Diabetes and Geriatric Medicine Akita University Graduate School of Medicine Akita Japan.
authors.forename: Tatsunori
authors.initials: T
authors.lastname: Shimizu
authors.affiliation: Department of Endocrinology, Diabetes and Geriatric Medicine Akita University Graduate School of Medicine Akita Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Fujita
authors.affiliation: Department of Endocrinology, Diabetes and Geriatric Medicine Akita University Graduate School of Medicine Akita Japan.
authors.forename: Takuma
authors.initials: T
authors.lastname: Narita
mesh_terms: D000818:Animals; D019858:Enteroendocrine Cells / Q000378:metabolism*; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D000067757:Glucagon-Like Peptide-1 Receptor / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D054795:Incretins / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism; D051379:Mice; D012527:Satiation / Q000502:physiology
chemical_list: D000067757:Glucagon-Like Peptide-1 Receptor; D054795:Incretins; D007328:Insulin; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1; D005947:Glucose
keywords: Gastric inhibitory polypeptide; Glucagon‐like peptide‐1; Incretin