title: Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides.
abstract: The MaxPHOX-Ir catalyst system provided the highest selectivity ever reported for the reduction of cyclic enamides derived from α- and β-tetralones. This result indicates that iridium catalysts are also proficient in reducing alkenes bearing metal-coordinating groups. In the present system, selectivity was pressure-dependent: In most cases, a decrease in the H2 pressure to 3 bar resulted in an increase in enantioselectivity. Moreover, the process can be carried out in environmentally friendly solvents, such as methanol and ethyl acetate, with no loss of selectivity.
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028, Barcelona, Spain.
authors.forename: Ernest
authors.initials: E
authors.lastname: Salomó
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028, Barcelona, Spain.
authors.forename: Sílvia
authors.initials: S
authors.lastname: Orgué
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028, Barcelona, Spain. antoni.riera@irbbarcelona.org.|Departament de Química Orgànica, Universitat de Barcelona, Martí i Franquès 1, 08028, Barcelona, Spain. antoni.riera@irbbarcelona.org.
authors.forename: Antoni
authors.identifier: 0000-0001-7142-7675
authors.initials: A
authors.lastname: Riera
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028, Barcelona, Spain. xavier.verdaguer@irbbarcelona.org.|Departament de Química Orgànica, Universitat de Barcelona, Martí i Franquès 1, 08028, Barcelona, Spain. xavier.verdaguer@irbbarcelona.org.
authors.forename: Xavier
authors.identifier: 0000-0002-9229-969X
authors.initials: X
authors.lastname: Verdaguer
keywords: P ligands; asymmetric hydrogenation; enamides; iridium; ligand design