title: Femtosecond laser capsulotomy versus manual capsulotomy: a Meta-analysis.
abstract: OBJECTIVE
  To perform a Meta-analysis on the precision and safety of femtosecond laser (FSL) capsulotomy compared with manual continuous curvilinear capsulotomy (CCC).
  
  
  METHODS
  We searched PubMed, EMBASE, Web of Science, the Cochrane Library databases, and Clinical Trials.gov that maintained our inclusion criteria. Reference lists of retrieved articles were also reviewed. The effects of morphology of capsulorhexis and the tears of anterior capsule were calculated by using random-effect models.
  
  
  RESULTS
  We identified 4 randomized and 7 nonrandomized studies involving 2941 eyes. The diameter of capsulotomy and the rates of anterior capsule tear showed no statistically difference between FSL group and manual group (MD=0.03; 95%CI, -0.03 to 0.09, P=0.31), and (OR=1.40; 95%CI, 0.28 to 6.97, P=0.68) respectively. In terms of the circularity of capsulotomy, FSL group had a more significant advantage than the manual CCC group (MD=0.09; 95%CI, 0.05 to 0.12, P<0.0001).
  
  
  CONCLUSIONS
  Our Meta-analysis shows that FSL can perform a capsulotomy with more precision and higher reliability than manual CCC. The results in diameter of capsulotomy and the rate of anterior capsule tears was no significant difference between FSL and manual CCC groups. However in terms of circularity, the FSL was superior to the manual procedure.
authors.affiliation: Southern Medical University, Guangzhou 510515, Guangdong Province, China; Department of Ophthalmology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong Province, China; Department of Ophthalmology, Pingshan New District People's Hopital of Shenzhen, Shenzhen 518118, Guangdong Province, China.
authors.forename: Dao-Wei
authors.initials: DW
authors.lastname: Qian
authors.affiliation: Department of Ophthalmology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong Province, China.
authors.forename: Hai-Ke
authors.initials: HK
authors.lastname: Guo
authors.affiliation: Southern Medical University, Guangzhou 510515, Guangdong Province, China; Department of Ophthalmology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong Province, China.
authors.forename: Shang-Li
authors.initials: SL
authors.lastname: Jin
authors.affiliation: Department of Ophthalmology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong Province, China.
authors.forename: Hong-Yang
authors.initials: HY
authors.lastname: Zhang
authors.affiliation: Southern Medical University, Guangzhou 510515, Guangdong Province, China; Department of Ophthalmology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong Province, China.
authors.forename: Yuan-Cun
authors.initials: YC
authors.lastname: Li
keywords: Meta-analysis; capsulotomy/capsulorhexis; cataract surgery; femtosecond laser; phacoemulsification