title: Suspected acute hemolytic transfusion reaction mediated by anti-Di(a).
abstract: Anti-Di(a) can mediate hemolytic disease of the fetus and newborn, but it is unclear if it can cause hemolytic transfusion reactions (HTRs). To date, there has only been one report of a possible immediate HTR attributed to anti-Di(a). Our case report details an immediate HTR due to anti-Di(a) in a patient with pre-existing liver failure. This reaction triggered multi-organ failure, and the patient subsequently died. This case also highlights the importance of considering HTRs even when routine antibody screening has been unremarkable, particularly when electronic crossmatch is used, because of the potential for an alloantibody against a low-prevalence antigen.
authors.affiliation: Haematology Department, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia.
authors.forename: Ashwini
authors.initials: A
authors.lastname: Bennett
authors.affiliation: Clinical Research Fellow, Department of Gastroenterology, Western General Hospital, Edinburgh, Scotland.
authors.forename: Ray K
authors.initials: RK
authors.lastname: Boyapati
authors.affiliation: Austin Pathology, Austin Hospital, Heidelberg, Victoria, Australia.
authors.forename: Frank S
authors.initials: FS
authors.lastname: Hong
mesh_terms: D017809:Fatal Outcome; D005260:Female; D006461:Hemolysis; D006801:Humans; D007518:Isoantibodies; D008875:Middle Aged; D009102:Multiple Organ Failure; D018029:Rho(D) Immune Globulin; D065227:Transfusion Reaction
chemical_list: D007518:Isoantibodies; D018029:Rho(D) Immune Globulin