title: Genetic variants of lncRNA HOTAIR and risk of epithelial ovarian cancer among Chinese women.
abstract: Ovarian cancer is one of the common female malignant tumors globally. However, exactly mechanism of ovarian cancer remained unknown. HOTAIR, a lncRNA in the mammalian HOXC locus, has been fully explored for its genetic variants, expression level and carcinogenesis, development and progression of multiple cancers, except for ovarian cancer. In this study, we hypothesized that abnormal expression of HOTAIR and common variants of HOTAIR are associated with risk of Epithelial ovarian cancer (EOC). We first evaluated the HOTAIR levels in 100 paired tissues of EOC patients and corresponding normal tissues. Results showed that the expression level of HOTAIR in EOC tissues was significantly higher than that in corresponding normal tissues. Then the genotyping analyses of HOTAIR gene was conducted in a Chinese population. The results indicated that rs4759314 and rs7958904 were significantly associated with EOC susceptibility. For rs4759314, the difference between the G allele (as the reference) and the A allele was statistically significant (adjusted OR, 1.34; 95% CI: 1.08-1.65; P = 6.8 × 10-3). For rs7958904, C allele was associated a significantly decreased EOC risk when compared with G allele (OR: 0.77; 95% CI: 0.67-0.89; P = 4.2 × 10-4). The study identified that HOTAIR variants could be a useful biomarker for the predisposition to EOC and for the early diagnosis of the disease.
authors.affiliation: Department of Gynecologic Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, China.
authors.forename: Haijing
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Gynecologic Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Shang
authors.affiliation: Department of Gynecologic Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Gynecologic Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, China.
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Gynecologic Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Gynecologic Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: The First Affiliated Hospital, Nanchang University, Nanchang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Gynecologic Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, China.
authors.forename: Shiqiang
authors.initials: S
authors.lastname: Xu
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D000077216:Carcinoma, Ovarian Epithelial; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000453:epidemiology / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D062085:RNA, Long Noncoding / Q000235:genetics*; D012307:Risk Factors
chemical_list: C561566:HOTAIR long untranslated RNA, human; D062085:RNA, Long Noncoding
keywords: HOTAIR; genetic variants; long noncoding RNA; ovarian cancer