title: Assessment of myocardial performance index in hypertensive patients with or without hyperuricaemia.
abstract: BACKGROUND
  Myocardial performance index (MPI) is impaired in patients with hypertension. Uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation, and vasoconstriction. Hyperuricaemia may provide a negative contribution to impaired MPI in hypertension.
  
  
  OBJECTIVE
  The study was designed to assess the MPI in hypertensive patients with or without hyperuricaemia.
  
  
  METHODS
  A total of 96 consecutive hypertensive patients were divided into two groups according to levels of serum uric acid (SUA); 49 normouricaemic patients (defined as SUA < 7.0 mg/dL in men and < 6.0 mg/dL in women) and 47 hyperuricaemic patients. SUA levels and other biochemistry parameters were determined by a standard analytical technique. All patients were evaluated by two-dimensional and Doppler echocardiography.
  
  
  RESULTS
  The two groups were similar according to age, body mass index, and smoking status. Mean MPI value (0.498 ± 0.06 vs. 0.410 ± 0.05, p < 0.001) was significantly higher in the hyperuricaemic group than the normouricaemic individuals and positively correlated with the mean value of SUA levels (r = 0.51, p < 0.001).
  
  
  CONCLUSIONS
  Our study demonstrated that high SUA levels were significantly associated with impaired MPI in hypertensive patients. SUA may suggest a valuable laboratory finding in assessing the risk of developing subclinical impaired left ventricular global function.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Basar
authors.affiliation: Department of Cardiology, University School of Medicine Hospital,, Sanliurfa.. feyzullahbesli@gmail.com.
authors.forename: Feyzullah
authors.initials: F
authors.lastname: Besli
authors.forename: Hakan
authors.initials: H
authors.lastname: Ozhan
authors.forename: Yasin
authors.initials: Y
authors.lastname: Turker
authors.forename: Osman
authors.initials: O
authors.lastname: Kayapinar
authors.forename: Mesut
authors.initials: M
authors.lastname: Kecebas
mesh_terms: D000368:Aged; D015150:Echocardiography, Doppler; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D033461:Hyperuricemia / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid
keywords: hypertension; myocardial performance index; serum uric acid