title: Beneficial effects of argan oil on blood pressure, insulin resistance, and oxidative stress in rat.
abstract: OBJECTIVE
  The aim of the present study was to investigate whether a 5-wk treatment with argan oil, which is known for its antioxidant properties, can reduce arterial hypertension, hyperglycemia, insulin resistance, and enhanced basal superoxide anion production and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in the aorta of glucose-fed rats.
  
  
  METHODS
  Sprague-Dawley rats had free access to a drinking solution containing 10% d-glucose or tap water (control) for 5 wk. The effect of argan oil in glucose-fed rats was compared with that of corn oil given daily by gavage (5 mL/kg) over a 5-wk period. Oxidative stress was evaluated by measuring the superoxide anion production and the NADPH oxidase activity using the lucigenin method.
  
  
  RESULTS
  The 5-wk treatment with glucose led to increases in systolic blood pressure, plasma glucose, and insulin levels as well as an increase in the insulin resistance index in association with a rise in superoxide anion production and NADPH oxidase activity (sensitive to diphenyleneiodonium) in the aorta. The simultaneous treatment with argan oil prevented or significantly reduced all of these effects, yet the same treatment with corn oil had a positive effect only on hyperinsulinemia and insulin resistance.
  
  
  CONCLUSIONS
  The findings from the present study demonstrated that argan oil treatment reduced elevation of blood pressure, hyperglycemia, and insulin resistance through its antioxidative properties in glucose-fed rats. Hence, argan oil, which is now available in the market as a consumable food, may be of potential therapeutic value in the treatment of arterial hypertension and insulin resistance.
authors.affiliation: Department of Molecular and Integrative Physiology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada; Department of Biology, FST Errachidia, Moulay Ismail University, Errachidia, Morocco. Electronic address: adil.el.midaoui@umontreal.ca.
authors.forename: Adil
authors.initials: A
authors.lastname: El Midaoui
authors.affiliation: Department of Molecular and Integrative Physiology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Youssef
authors.initials: Y
authors.lastname: Haddad
authors.affiliation: Department of Molecular and Integrative Physiology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Réjean
authors.initials: R
authors.lastname: Couture
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D005947:Glucose / Q000008:administration & dosage; D006943:Hyperglycemia / Q000517:prevention & control; D006973:Hypertension / Q000517:prevention & control; D007333:Insulin Resistance; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010938:Plant Oils / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000975:Antioxidants; D010938:Plant Oils; C555574:argan oil; D005947:Glucose
keywords: Argan oil; Hypertension; Insulin resistance; NADPH oxidase; Oxidative stress