title: Origanum majorana Attenuates Nephrotoxicity of Cisplatin Anticancer Drug through Ameliorating Oxidative Stress.
abstract: Despite the fact that cisplatin is an important anticancer drug, its clinical utilization is limited by nephrotoxicity during long term medication. Combined cisplatin chemotherapy with plant extracts can diminish toxicity and enhance the antitumor efficacy of the drug. This study evaluated the effect of Originum majorana ethanolic extract (OMEE) on cisplatin-induced nephrotoxicity. Eighteen male rats were divided into three groups as follows: a control group, a group treated with cisplatin (3 mg/kg body weight), and a group that received both cisplatin and OMEE (500 mg/kg body weight) for 14 days. Cisplatin induced a significant increase in creatinine, urea, uric acid, blood urea nitrogen, malondialdehyde, and nitric oxide levels. However, glutathione, superoxide dismutase, and catalase levels were significantly diminished. Conversely, OMEE significantly modulated the renal and oxidative markers negatively impacted by cisplatin. OMEE significantly reduced the effects of cisplatin-induced changes in renal and oxidative markers, possibly through its free radical scavenging activity. Thus, OMEE may be combined with cisplatin to alleviate nephrotoxicity in cancer chemotherapy.
authors.affiliation: Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt. soliman.amel5@gmail.com.
authors.forename: Amel M
authors.initials: AM
authors.lastname: Soliman
authors.affiliation: Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt. shereen_desokey@yahoo.com.
authors.forename: Shreen
authors.initials: S
authors.lastname: Desouky
authors.affiliation: Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt. marzouk@sci.cu.edu.eg.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Marzouk
authors.affiliation: Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt. amanyasayed@sci.cu.edu.eg.
authors.forename: Amany A
authors.initials: AA
authors.lastname: Sayed
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002945:Cisplatin / Q000633:toxicity*; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D031341:Origanum; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D002945:Cisplatin
keywords: Originum majorana; cisplatin; nephrotoxicity; oxidative stress