title: Glucose Control in the ICU: A Continuing Story.
abstract: In the present era of near-continuous glucose monitoring (CGM) and automated therapeutic closed-loop systems, measures of accuracy and of quality of glucose control need to be standardized for licensing authorities and to enable comparisons across studies and devices. Adequately powered, good quality, randomized, controlled studies are needed to assess the impact of different CGM devices on the quality of glucose control, workload, and costs. The additional effects of continuing glucose control on the general floor after the ICU stay also need to be investigated. Current algorithms need to be adapted and validated for CGM, including effects on glucose variability and workload. Improved collaboration within the industry needs to be encouraged because no single company produces all the necessary components for an automated closed-loop system. Combining glucose measurement with measurement of other variables in 1 sensor may help make this approach more financially viable.
authors.affiliation: Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Brussels, Belgium Jean-Charles.Preiser@erasme.ulb.ac.be.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Preiser
authors.affiliation: Department of Mechanical Engineering, Centre for Bio-Engineering, University of Canterbury, Christchurch, New Zealand.
authors.forename: J Geoffrey
authors.initials: JG
authors.lastname: Chase
authors.affiliation: University of Cambridge Metabolic Research Laboratories, Level 4, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Roman
authors.initials: R
authors.lastname: Hovorka
authors.affiliation: Department of Anesthesiology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Joseph
authors.affiliation: Division of Critical Care, Department of Medicine, Stamford Hospital, Columbia University College of Physicians and Surgeons, Stamford, CT, USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Krinsley
authors.affiliation: Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Edegem, Belgium.
authors.forename: Christophe
authors.initials: C
authors.lastname: De Block
authors.affiliation: GIGA-Cardiovascular Sciences, Université de Liège, Liège, Belgium.
authors.forename: Thomas
authors.initials: T
authors.lastname: Desaive
authors.affiliation: Department of Anesthesia and Intensive Care Medicine, OLV Clinic, Aalst, Belgium.
authors.forename: Luc
authors.initials: L
authors.lastname: Foubert
authors.affiliation: Service de Réanimation polyvalente, Hôpital Louis Pasteur, CH de Chartres, Chartres, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Kalfon
authors.affiliation: Department of Health Science and Technology, Aalborg University, Aalborg Øst, Denmark.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Pielmeier
authors.affiliation: Department of Intensive Care Medicine-Department of Electrical Engineering (STADIUS), Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Tom
authors.initials: T
authors.lastname: Van Herpe
authors.affiliation: Karolinska University Hospital Huddinge and Karolinska Institutet, Stockholm, Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Wernerman
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D007362:Intensive Care Units; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods
chemical_list: D001786:Blood Glucose
keywords: continuous glucose control; diabetes; intensive care; time in band