title: Tunable DNA cleavage activity promoted by copper(ii) ternary complexes with N-donor heterocyclic ligands.
abstract: Several small molecules have the capacity to cleave DNA promptly at high yields, even under mild conditions. Usually, this activity has no constraints, occurring without external or user control. Here, we demonstrate that UV-light exposure can greatly enhance the DNA cleavage activity promoted by four ternary copper(ii) complexes. A remarkable photocontrolled activity was achieved, which may be interesting for chemical and biochemical applications.
authors.affiliation: Centro de Biologia Molecular Estrutural, Departamento de Bioquímica, Universidade Federal de Santa Catarina, 88040-970, Florianópolis-SC, Brazil. hernan.terenzi@ufsc.br.
authors.forename: T
authors.initials: T
authors.lastname: Bortolotto
authors.forename: P P
authors.initials: PP
authors.lastname: Silva-Caldeira
authors.forename: C T
authors.initials: CT
authors.lastname: Pich
authors.forename: E C
authors.initials: EC
authors.lastname: Pereira-Maia
authors.forename: H
authors.initials: H
authors.lastname: Terenzi
mesh_terms: D003300:Copper / Q000737:chemistry / Q000494:pharmacology*; D053837:DNA Cleavage; D004305:Dose-Response Relationship, Drug; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D014466:Ultraviolet Rays
chemical_list: D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D003300:Copper