title: Total Synthesis of (+)-Minfiensine: Construction of the Tetracyclic Core Structure by an Asymmetric Cascade Cyclization.
abstract: A new method for one-step construction of the tetracyclic core structure of the indole alkaloid (+)-minfiensine was developed utilizing a palladium-catalyzed asymmetric indole dearomatization/iminium cyclization cascade. An efficient total synthesis of (+)-minfiensine was realized using this strategy. The present method enables access to the common core structure of a series of monoterpene indole alkaloids, such as vincorine, echitamine, and aspidosphylline A.
authors.affiliation: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors.forename: Ze-Xin
authors.initials: ZX
authors.lastname: Zhang
authors.affiliation: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors.forename: Si-Cong
authors.initials: SC
authors.lastname: Chen
authors.affiliation: Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing, 100084, China. Leijiao@mail.tsinghua.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Jiao
keywords: alkaloids; cyclizations; natural products; palladium; total synthesis