title: A rare case of multicentric secretory carcinoma of breast in an adult female with review of literature.
abstract: Secretory breast carcinomas (SBCs) are considered one of the rarest types of BCs accounting for <0.15% of all breast cancers. The lesions are typically solitary, but rare multicentric cases have been reported. SBC have characteristic histopathological, immunohistochemical, and electron microscopic findings. Children and adolescents with SBC have a favorable prognosis, but disease seems slightly more aggressive in adults. The characteristic ETV6-NTRK3 molecular alteration, leading to a stable chimeric tyrosine kinase fusion product, may be the target of promising new treatment for this unique BC. We present a rare case of multicentric secretory carcinoma of breast with aggressive clinical behavior in a 75-year-old female.
authors.affiliation: Department of Pathology, Smt. Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India.
authors.forename: Maithili Mandar
authors.initials: MM
authors.lastname: Kulkarni
authors.affiliation: Department of Pathology, Smt. Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India.
authors.forename: Siddhi Gaurish Sinai
authors.initials: SG
authors.lastname: Khandeparkar
authors.affiliation: Department of Pathology, Smt. Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India.
authors.forename: Avinash R
authors.initials: AR
authors.lastname: Joshi
authors.affiliation: Department of Pathology, Smt. Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, India.
authors.forename: Ashish N
authors.initials: AN
authors.lastname: Dhande