title: Comparative dosimetry for children and rodents exposed to extremely low-frequency magnetic fields.
abstract: We describe a method to correlate E-fields induced by exposure to extremely low frequency magnetic fields in laboratory mice and rats during in vivo experiments to those induced in children. Four different approaches of mapping relative dose rates between humans and rodents are herein proposed and analyzed. Based on these mapping methods and volume averaging guidelines published by the International Commission on Non-Ionizing Radiation Protection (ICNRP) in 2010, maximum and median induced field values for whole body and for tissues of children and rodents were evaluated and compared. Median induced electric fields in children younger than 10 years old are in the range 5.9-8.5 V/m per T (±0.4 dB). Maximum induced electric fields, generally in the skin, are between 48 V/m and 228 V/m per T (±4 dB). To achieve induced electric fields of comparable magnitude in rodents, external magnetic field must be increased by a factor of 4.0 (±2.6 dB) for rats and 7.4 (±1.8 dB) for mice. Meanwhile, to achieve comparable magnetic field dose in rodents, ratio is close to one. These induced field dose rates for children and rodents can be used to quantifiably compare experimental data from in vivo studies with data on exposure of children from epidemiological studies, such as for leukemia. Bioelectromagnetics. 37:310-322, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: IT'IS Foundation, Zurich, Switzerland.|Information Technology and Electrical Engineering, ETHZ, Zurich, Switzerland.
authors.forename: Yijian
authors.initials: Y
authors.lastname: Gong
authors.affiliation: IT'IS Foundation, Zurich, Switzerland.
authors.forename: Myles
authors.initials: M
authors.lastname: Capstick
authors.affiliation: ITEM, Fraunhofer Institute, Hannover, Germany.
authors.forename: Clemens
authors.initials: C
authors.lastname: Dasenbrock
authors.affiliation: Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany.
authors.forename: Maren
authors.initials: M
authors.lastname: Fedrowitz
authors.affiliation: Centro de Biologia Molecular Severo Ochoa, CSIC/UAM, Madrid, Spain.
authors.forename: Cesar
authors.initials: C
authors.lastname: Cobaleda
authors.affiliation: Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca, Salamanca, Spain.
authors.forename: Isidro
authors.initials: I
authors.lastname: Sánchez-García
authors.affiliation: IT'IS Foundation, Zurich, Switzerland.|Information Technology and Electrical Engineering, ETHZ, Zurich, Switzerland.
authors.forename: Niels
authors.initials: N
authors.lastname: Kuster
mesh_terms: D000818:Animals; D002648:Child; D002675:Child, Preschool; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007223:Infant; D060526:Magnetic Fields; D008297:Male; D051379:Mice; D011874:Radiometry / Q000379:methods*; D051381:Rats; D013045:Species Specificity; D035501:Uncertainty
keywords: childhood leukemia; growth rate mapping; numerical dosimetry; power line exposure; rodent exposure