title: Two new sesquiterpenoid glycosides from the leaves of Lycium barbarum.
abstract: Two new sesquiterpenoid glycosides, lyciumionosides A-B (1-2), together with four known compounds (3-6), were isolated from the leaves of Lycium barbarum. Their structures were mainly established on the basis of MS, 1D and 2D NMR spectroscopic techniques. The antiproliferative activities of compounds 1-5 were evaluated. Compound 1 showed highest inhibitory activity against A549 cells with IC50 value of 32.6 ± 2.6 μM, compound 3 showed highest inhibitory activity against PC-3 cells with IC50 value of 36.0 ± 2.9 μM, and compound 5 exhibited highest inhibitory activity against HeLa cells with IC50 value of 32.3 ± 4.2 μM.
authors.affiliation: a Key Laboratory of Plant Resources and Chemistry in Arid Regions , Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.|c University of Chinese Academy of Sciences , Beijing 100039 , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: b Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhao
authors.affiliation: a Key Laboratory of Plant Resources and Chemistry in Arid Regions , Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.
authors.forename: Hai-Rong
authors.initials: HR
authors.lastname: Ma
authors.affiliation: a Key Laboratory of Plant Resources and Chemistry in Arid Regions , Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.|b Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.
authors.forename: Haji Akber
authors.initials: HA
authors.lastname: Aisa
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D032305:Lycium / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D012717:Sesquiterpenes; C000613858:lyciumionoside A; C000613859:lyciumionoside B
keywords: Lycium barbarum; Solanaceae; antiproliferative activities; sesquiterpenoid glycosides