title: Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery.
abstract: Human pain models are useful in the assessing the analgesic effect of drugs, providing information about a drug's pharmacology and identify potentially suitable therapeutic populations. The need to use a comprehensive battery of pain models is highlighted by studies whereby only a single pain model, thought to relate to the clinical situation, demonstrates lack of efficacy. No single experimental model can mimic the complex nature of clinical pain. The integrated, multi-modal pain task battery presented here encompasses the electrical stimulation task, pressure stimulation task, cold pressor task, the UVB inflammatory model which includes a thermal task and a paradigm for inhibitory conditioned pain modulation. These human pain models have been tested for predicative validity and reliability both in their own right and in combination, and can be used repeatedly, quickly, in short succession, with minimum burden for the subject and with a modest quantity of equipment. This allows a drug to be fully characterized and profiled for analgesic effect which is especially useful for drugs with a novel or untested mechanism of action.
authors.affiliation: Centre for Human Drug Research (CHDR); JHay@chdr.nl.
authors.forename: Justin L
authors.initials: JL
authors.lastname: Hay
authors.affiliation: Centre for Human Drug Research (CHDR).
authors.forename: Pieter
authors.initials: P
authors.lastname: Okkerse
authors.affiliation: Centre for Human Drug Research (CHDR).
authors.forename: Guido
authors.initials: G
authors.lastname: van Amerongen
authors.affiliation: Centre for Human Drug Research (CHDR).
authors.forename: Geert Jan
authors.initials: GJ
authors.lastname: Groeneveld
mesh_terms: D003080:Cold Temperature; D004361:Drug Tolerance; D006801:Humans; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement; D017288:Pain Threshold; D015203:Reproducibility of Results