title: Uric acid excretion predicts increased aggression in urban adolescents.
abstract: Elevated levels of uric acid have been linked with impulsive and disinhibited behavior in clinical and community populations of adults, but no studies have examined uric acid in relation to adolescent aggression. This study examined the prospective role of uric acid in aggressive behavior among urban, low income adolescents, and whether this relationship varies by gender. A total of 84 adolescents (M age 13.36years; 50% male; 95% African American) self-reported on their physical aggression at baseline and 1.5years later. At baseline, the youth also completed a 12-h (overnight) urine collection at home which was used to measure uric acid excretion. After adjusting for baseline aggression and age, greater uric acid excretion predicted more frequent aggressive behavior at follow up, with no significant gender differences. The results suggest that lowering uric acid levels may help reduce youth aggression.
authors.affiliation: Department of Psychology, University of Alabama at Birmingham, 1720 2(nd) Ave South, Birmingham, AL 35294, United States. Electronic address: smrug@uab.edu.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Mrug
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, 1720 2(nd) Ave South, Birmingham, AL 35294, United States.
authors.forename: Michal
authors.initials: M
authors.lastname: Mrug
mesh_terms: D000293:Adolescent; D000374:Aggression; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D012737:Sex Factors; D014505:Urban Population; D014527:Uric Acid / Q000652:urine*
chemical_list: D014527:Uric Acid; D003404:Creatinine
keywords: Adolescence; Aggression; Uric acid