title: Prevalence of RHD alleles in Japanese individuals with weak D phenotype: Identification of 20 new RHD alleles.
abstract: We identified 46 different RHD alleles from 226 Japanese individuals with weak D phenotype, 26 of which had been previously described and 20 that were novel. Among these weak D individuals, the alleles with c.960G>A, c.845G>A (RHD*15) or c.1013T>C (RHD*01W.24) mutations were most prevalent with relative occurrences of 36·7%, 15·9% and 9·7%, respectively. These findings demonstrate that the prevalence of common weak D alleles in the Japanese population significantly differs from that of Caucasian populations.
authors.affiliation: Japanese Red Cross Central Blood Institute, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Isa
authors.affiliation: Japanese Red Cross Central Blood Institute, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.affiliation: Japanese Red Cross Central Blood Institute, Tokyo, Japan. k-ogasawara@jrc.or.jp.
authors.forename: K
authors.initials: K
authors.lastname: Ogasawara
authors.affiliation: Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.affiliation: Japanese Red Cross Central Blood Institute, Tokyo, Japan.|Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tsuneyama
authors.affiliation: Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Yabe
authors.affiliation: Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Uchikawa
authors.affiliation: Japanese Red Cross Central Blood Institute, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Satake
mesh_terms: D000483:Alleles; D006801:Humans; D007564:Japan; D018895:Microsatellite Repeats / Q000235:genetics; D020125:Mutation, Missense; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012204:Rh-Hr Blood-Group System / Q000235:genetics*
chemical_list: D012204:Rh-Hr Blood-Group System
keywords: RHD gene; Rh blood group; weak D