title: A Synthetic Replicator Drives a Propagating Reaction-Diffusion Front.
abstract: A simple synthetic autocatalytic replicator is capable of establishing and driving the propagation of a reaction-diffusion front within a 50 μL syringe. This replicator templates its own synthesis through a 1,3-dipolar cycloaddition reaction between a nitrone component, equipped with a 9-ethynylanthracene optical tag, and a maleimide. Kinetic studies using NMR and UV-vis spectroscopies confirm that the replicator forms efficiently and with high diastereoselectivity, and this replication process brings about a dramatic change in optical properties of the sample-a change in the color of the fluorescence in the sample from yellow to blue. The addition of a small amount of the preformed replicator at a specific location within a microsyringe, filled with the reaction building blocks, results in the initiation and propagation of a reaction-diffusion front. The realization of a replicator capable of initiating a reaction-diffusion front provides a platform for the examination of interconnected replicating networks under out-of-equilibrium conditions involving diffusion processes.
authors.affiliation: School of Chemistry and EaStCHEM, University of St Andrews , North Haugh, St Andrews, Fife KY16 9ST, U.K.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Bottero
authors.affiliation: School of Chemistry and EaStCHEM, University of St Andrews , North Haugh, St Andrews, Fife KY16 9ST, U.K.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Huck
authors.affiliation: School of Chemistry and EaStCHEM, University of St Andrews , North Haugh, St Andrews, Fife KY16 9ST, U.K.
authors.forename: Tamara
authors.initials: T
authors.lastname: Kosikova
authors.affiliation: School of Chemistry and EaStCHEM, University of St Andrews , North Haugh, St Andrews, Fife KY16 9ST, U.K.
authors.forename: Douglas
authors.initials: D
authors.lastname: Philp