title: Low aneuploidy rate in early pregnancy loss abortuses from patients with polycystic ovary syndrome.
abstract: A prospective cohort study was conducted to determine whether chromosome aneuploidy increases the risk of early spontaneous abortions in patients with polycystic ovary syndrome (PCOS). A total of 1461 patients who conceived after IVF and embryo transfer were followed; 100 patients who had experienced clinical spontaneous abortion were recruited, 32 with PCOS and 68 without PCOS. Before 2013, genetic analysis comprised conventional cultured villus chromosome karyotyping and a multiplex ligation-dependent probe amplification subtelomere assay combined with fluorescence in-situ hybridization; since 2013, array-based comparative genomic hybridization technique combined with chromosome karyotyping has been used. Age, BMI, pregnancy history, gestational age and total gonadotrophin dosage did not differ significantly between the PCOS and non-PCOS groups. In the PCOS group, 28.1% of abortuses demonstrated aneuploidy, which was significantly lower (P = 0.001) than in the non-PCOS group (72.1%). Further statistical analyses controlling for maternal age demonstrated that abortuses of women with PCOS were significantly less (P = 0.001) likely to have chromosome aneuploidy. Embryonic aneuploidy does not play a vital role in early spontaneous abortion in women with PCOS. Maternal factors resulting in endometrial disorders are more likely to be responsible for the increased risk of early spontaneous abortion in patients with PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, The Center of Reproductive Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, The Center of Reproductive Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Obstetrics, Guangdong Women and Children Hospital, Guangzhou, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Lei
authors.affiliation: Department of Obstetrics and Gynecology, The Center of Reproductive Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, China; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
authors.forename: Ming-Mei
authors.initials: MM
authors.lastname: Lin
authors.affiliation: Department of Obstetrics and Gynecology, The Center of Reproductive Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Obstetrics and Gynecology, The Center of Reproductive Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, China.
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Chen
authors.affiliation: Department of Obstetrics and Gynecology, The Center of Reproductive Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, China.
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Zeng
authors.affiliation: Department of Obstetrics and Gynecology, The Center of Reproductive Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, China. Electronic address: zhoucanquan@hotmail.com.
authors.forename: Can-Quan
authors.initials: CQ
authors.lastname: Zhou
mesh_terms: D037881:Aborted Fetus; D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D000782:Aneuploidy; D002824:Chorionic Villi / Q000378:metabolism; D002875:Chromosomes / Q000648:ultrastructure; D055028:Comparative Genomic Hybridization; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007333:Insulin Resistance; D007621:Karyotyping; D008423:Maternal Age; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000235:genetics*; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism; D011446:Prospective Studies; D012306:Risk
chemical_list: D011374:Progesterone
keywords: IVF; aneuploidy; chromosome; early miscarriage; embryo; polycystic ovary syndrome