title: Advances of Proteomic Sciences in Dentistry.
abstract: Applications of proteomics tools revolutionized various biomedical disciplines such as genetics, molecular biology, medicine, and dentistry. The aim of this review is to highlight the major milestones in proteomics in dentistry during the last fifteen years. Human oral cavity contains hard and soft tissues and various biofluids including saliva and crevicular fluid. Proteomics has brought revolution in dentistry by helping in the early diagnosis of various diseases identified by the detection of numerous biomarkers present in the oral fluids. This paper covers the role of proteomics tools for the analysis of oral tissues. In addition, dental materials proteomics and their future directions are discussed.
authors.affiliation: Department of Prosthodontics and Dental Materials, School of Dentistry, King Faisal University, Al-Hofuf 31982, Saudi Arabia. drzohaibkhurshid@gmail.com.
authors.forename: Zohaib
authors.initials: Z
authors.lastname: Khurshid
authors.affiliation: Department of Biomedical Engineering, College of Engineering, King Faisal University, Al-Hofuf 31982, Saudi Arabia. szohaib@kfu.edu.sa.
authors.forename: Sana
authors.initials: S
authors.lastname: Zohaib
authors.affiliation: Department of Restorative Dental Sciences, Al Farabi Colleges, Riyadh 11313, Saudi Arabia. shariqnajeeb@gmail.com.
authors.forename: Shariq
authors.initials: S
authors.lastname: Najeeb
authors.affiliation: Department of Restorative Dentistry, College of Dentistry, Taibah University, Madina Munawwarrah 41311, Saudi Arabia. MZAFAR@taibahu.edu.sa.
authors.forename: Muhammad Sohail
authors.initials: MS
authors.lastname: Zafar
authors.affiliation: Department of Biomedical Engineering, College of Engineering, King Faisal University, Al-Hofuf 31982, Saudi Arabia. rimtiaz@kfu.edu.sa.
authors.forename: Rabia
authors.initials: R
authors.lastname: Rehman
authors.affiliation: Department of Materials Science and Engineering, The Kroto Research Institute, The University of Sheffield, North Campus, Broad Lane, Sheffield S3 7HQ, UK. i.u.rehman@sheffield.ac.uk.
authors.forename: Ihtesham Ur
authors.initials: IU
authors.lastname: Rehman
mesh_terms: D003764:Dental Materials / Q000009:adverse effects / Q000592:standards; D003813:Dentistry / Q000379:methods*; D006801:Humans; D010519:Periodontium / Q000187:drug effects / Q000378:metabolism; D020543:Proteome / Q000235:genetics / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D014070:Tooth / Q000187:drug effects / Q000378:metabolism
chemical_list: D003764:Dental Materials; D020543:Proteome
keywords: dentin; dentistry; enamel; gingival crevicular fluids and dental materials; proteomics; saliva