title: Serum Folate Shows an Inverse Association with Blood Pressure in a Cohort of Chinese Women of Childbearing Age: A Cross-Sectional Study.
abstract: It has been reported that higher folate intake from food and supplementation is associated with decreased blood pressure (BP). The association between serum folate concentration and BP has been examined in few studies. We aim to examine the association between serum folate and BP levels in a cohort of young Chinese women.
  
  
  
  We used the baseline data from a pre-conception cohort of women of childbearing age in Liuyang, China, for this study. Demographic data were collected by structured interview. Serum folate concentration was measured by immunoassay, and homocysteine, blood glucose, triglyceride and total cholesterol were measured through standardized clinical procedures. Multiple linear regression and principal component regression model were applied in the analysis.
  
  
  
  A total of 1,532 healthy normotensive non-pregnant women were included in the final analysis. The mean concentration of serum folate was 7.5 ± 5.4 nmol/L and 55% of the women presented with folate deficiency (< 6.8 nmol/L). Multiple linear regression and principal component regression showed that serum folate levels were inversely associated with systolic and diastolic BP, after adjusting for demographic, anthropometric, and biochemical factors.
  
  
  
  Serum folate is inversely associated with BP in non-pregnant women of childbearing age with high prevalence of folate deficiency.
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan, People's Republic of China.|OMNI Research Group, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.|Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada.
authors.forename: Minxue
authors.initials: M
authors.lastname: Shen
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Hongzhuan
authors.initials: H
authors.lastname: Tan
authors.affiliation: Liuyang Maternal and Child Hospital, Department of maternal and child health care, Liuyang, Hunan, People's Republic of China.
authors.forename: Shujin
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Division of Endocrinology, Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.
authors.forename: Ravi
authors.initials: R
authors.lastname: Retnakaran
authors.affiliation: Department of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada.
authors.forename: Graeme N
authors.initials: GN
authors.lastname: Smith
authors.affiliation: Women and Children's Health Research Institute, University of Alberta, Edmonton, Alberta, Canada.|Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada.|Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Sandra T
authors.initials: ST
authors.lastname: Davidge
authors.affiliation: Department of Pediatrics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.|Department of Human Genetics, Research Institute of the McGill University Health Centre at The Montreal Children's Hospital, Montreal, Quebec, Canada.|Department of Pharmacology and Therapeutics, Research Institute of the McGill University Health Centre at The Montreal Children's Hospital, Montreal, Quebec, Canada.
authors.forename: Jacquetta
authors.initials: J
authors.lastname: Trasler
authors.affiliation: OMNI Research Group, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.|Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada.|School of Epidemiology, Public Health, and Preventive Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Walker
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan, People's Republic of China.|OMNI Research Group, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.|Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, Ontario, Canada.|School of Epidemiology, Public Health, and Preventive Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Shi Wu
authors.initials: SW
authors.lastname: Wen
mesh_terms: D000328:Adult; D000367:Age Factors; D044466:Asian People; D015415:Biomarkers; D001794:Blood Pressure; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005492:Folic Acid / Q000097:blood*; D006801:Humans; D011247:Pregnancy; D062486:Public Health Surveillance; D012737:Sex Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005492:Folic Acid