title: CYLD - a deubiquitylase that acts to fine-tune microtubule properties and functions.
abstract: Microtubules are dynamic structures that are crucially involved in a variety of cellular activities. The dynamic properties and functions of microtubules are regulated by various factors, such as tubulin isotype composition and microtubule-binding proteins. Initially identified as a deubiquitylase with tumor-suppressing functions, the protein cylindromatosis (CYLD) has recently been revealed to interact with microtubules, modulate microtubule dynamics, and participate in the regulation of cell migration, cell cycle progression, chemotherapeutic drug sensitivity and ciliogenesis. These findings have greatly enriched our understanding of the roles of CYLD in physiological and pathological conditions. Here, we focus on recent literature that shows how CYLD impacts on microtubule properties and functions in various biological processes, and discuss the challenges we face when interpreting results obtained from different experimental systems.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
authors.forename: Yunfan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China Institute of Biomedical Sciences, College of Life Sciences, Key Laboratory of Animal Resistance of Shandong Province, Key Laboratory of Molecular and Nano Probes of the Ministry of Education, Shandong Normal University, Jinan 250014, China junzhou@nankai.edu.cn.
authors.forename: Jun
authors.identifier: 0000-0001-7858-8260
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002465:Cell Movement; D002923:Cilia / Q000378:metabolism; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D008954:Models, Biological; D064570:Ubiquitin-Specific Proteases / Q000378:metabolism*
chemical_list: D064570:Ubiquitin-Specific Proteases
keywords: CYLD; Cell cycle; Cell migration; Ciliogenesis; Drug sensitivity; Microtubule