title: Recovery of Vestibulo-Ocular Reflex Symmetry After an Acute Unilateral Peripheral Vestibular Deficit: Time Course and Correlation With Canal Paresis.
abstract: We investigated how response asymmetries and deficit side response amplitudes for head accelerations used clinically to test the vestibular ocular reflex (VOR) are correlated with caloric canal paresis (CP) values.
  
  
  
  30 patients were examined at onset of an acute unilateral peripheral vestibular deficit (aUPVD) and 3, 6, and 13 weeks later with three different VOR tests: caloric, rotating chair (ROT), and video head impulse tests (vHIT). Response changes over time were fitted with an exponential decay model and compared with using linear regression analysis.
  
  
  
  Recovery times (to within 10% of steady state) were similar for vHIT-asymmetry and CP (>10 weeks) but shorter for ROT asymmetry (<4 weeks). Regressions with CP were similar (vHIT asymmetry, R = 0.68, ROT, R = 0.62). Responses to the deficit side were also equally well correlated with CP values (R = 0.71). Specificity for vHIT and 20 degrees/s ROT deficit side responses was 100% in comparison to CP values, sensitivity was 74% for vHIT, 75% for ROT. A decrease in normal side responses occurred for ROT but not for vHIT at 3 weeks. Normal side responses were weekly correlated with CP for ROT (R = 0.49) but not for vHIT (R = 0.17).
  
  
  
  These results indicate that vHIT deficit side VOR gains are slightly better correlated with CP values than ROT, probably because of similar recovery time courses of vHIT and caloric responses and the lack of normal side vHIT changes. However, specificity and sensitivity is the same for vHIT and ROT tests.
authors.affiliation: *Division of Audiology and Neurootology, Department of ORL, University Hospital of Basel, Basel, Switzerland†School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: John H J
authors.initials: JH
authors.lastname: Allum
authors.forename: T
authors.initials: T
authors.lastname: Cleworth
authors.forename: Flurin
authors.initials: F
authors.lastname: Honegger
mesh_terms: D000328:Adult; D002150:Caloric Tests / Q000379:methods; D005260:Female; D064087:Head Impulse Test / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function / Q000502:physiology*; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*; D020338:Vestibular Neuronitis / Q000175:diagnosis / Q000503:physiopathology*; D014722:Vestibule, Labyrinth / Q000503:physiopathology