title: EnABLing microprocessor for apoptosis.
abstract: The Microprocessor complex consisting of DROSHA (a type III ribonuclease) and DGCR8 (DiGeorge syndrome critical region gene 8-encoded RNA binding protein) recognizes and cleaves the precursor microRNA hairpin (pre-miRNA) from the primary microRNA transcript (pri-miRNA). The Abelson tyrosine kinase 1 (ABL) phosphorylates DGCR8 to stimulate the cleavage of a subset of pro-apoptotic pri-miRNAs, thus expanding the nuclear functions of ABL to include regulation of RNA processing.
authors.affiliation: Department of Medicine, Division of Hematology-Oncology, Moores Cancer Center, University of California, San Diego, School of Medicine, La Jolla, CA.
authors.forename: Chi-Chiang
authors.initials: CC
authors.lastname: Tu
authors.affiliation: Department of Medicine, Division of Hematology-Oncology, Moores Cancer Center, University of California, San Diego, School of Medicine, La Jolla, CA.
authors.forename: Jean Y J
authors.initials: JY
authors.lastname: Wang
keywords: ABL; BCR-ABL; DGC; DNA damage response; DROSHA; R8; tyrosine phosphorylation