title: Lesion-symptom mapping of a complex figure copy task: A large-scale PCA study of the BCoS trial.
abstract: Complex figure copying is a commonly used neuropsychological test. Here we explored the neural basis of the factors underlying complex figure copying (CFC), using data from the Birmingham Cognitive Screen (BCoS) in a large group of sub-acute, ischemic stroke patients (239). We computed two analyses: in the first we assessed the contribution of co-morbid deficits (i.e. in gesture processing, object use, visual neglect, pictures naming and sustained attention) to the lesions associated with CFC. In a second analysis a Principle Component Analysis (PCA) was used to isolate different underlying task components and to link to clinical neuroimaging scans. A voxel-based morphometry (VBM) analysis showed that poor CFC performance was associated with lesions to bi-lateral thalamus, lingual, right fusiform and right inferior parietal cortices (rIPC). The latter association with the posterior parietal cortex was diminished after controlling for neglect. Follow up analysis showed the neglect partially mediated the correlation of CFC and rIPC. The PCA revealed three main underlying components: (1) a component associated with high-level motor control common to different measures of apraxia and linked to the left postcentral gyrus, the right thalamus and middle frontal gyrus; (2) a visuo-motor transformation component unique to the CFC and associated with lesions to the posterior occipital and sensory cortices; (3) a component associated with multistep object use tasks which was correlated with lesions to the left inferior frontal orbital gyrus, the right fusiform and cerebellum. Using clinical symptoms, cognitive profiles and lesion mapping we showed that beyond visual perception, CFC performance is supported by three functional networks: one for high-level motor control, a visuo-motor transformation component, and multistep object use network.
authors.affiliation: Department of Neurology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510000, PR China; School of Psychology, University of Birmingham, Birmingham, B15 2TT, UK. Electronic address: hxc454@bham.ac.uk.
authors.forename: Haobo
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Neurology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510000, PR China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Pan
authors.affiliation: School of Psychology, University of Birmingham, Birmingham, B15 2TT, UK.
authors.forename: Johnny King Lam
authors.initials: JKL
authors.lastname: Lau
authors.affiliation: School of Psychology, University of Birmingham, Birmingham, B15 2TT, UK.
authors.forename: Wai-Ling
authors.initials: WL
authors.lastname: Bickerton
authors.affiliation: Consultant in Old Age Psychiatry, Avon & Wiltshire NHS Trust, Green Lane Hospital, Devizes, Wiltshire SN105 DS, UK.
authors.forename: Boddana
authors.initials: B
authors.lastname: Pradeep
authors.affiliation: School of Psychology, University of Birmingham, Birmingham, B15 2TT, UK.
authors.forename: Maliheh
authors.initials: M
authors.lastname: Taheri
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK.
authors.forename: Glyn
authors.initials: G
authors.lastname: Humphreys
authors.affiliation: School of Psychology, University of Birmingham, Birmingham, B15 2TT, UK.
authors.forename: Pia
authors.initials: P
authors.lastname: Rotshtein
mesh_terms: D000161:Acoustic Stimulation; D000223:Adaptation, Psychological / Q000502:physiology*; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D001931:Brain Mapping; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010468:Perceptual Disorders / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D010775:Photic Stimulation; D025341:Principal Component Analysis; D021641:Recognition, Psychology; D013028:Space Perception; D020521:Stroke / Q000150:complications; D015898:Tomography Scanners, X-Ray Computed
keywords: Apraxia; CT; Constructional apraxia; Drawing; High-level motor control; Stroke; VBM; Visuo-motor transformation