title: Changes in serum adipocyte fatty acid-binding protein in women with gestational diabetes mellitus and normal pregnant women during mid- and late pregnancy.
abstract: OBJECTIVE
  To observe the longitudinal changes in serum adipocyte fatty acid-binding protein (AFABP), carbohydrate, and lipid metabolism parameters in women with and without gestational diabetes mellitus (GDM) during mid- and late pregnancy periods, as well as to identify whether there is any association between AFABP and development of GDM.
  
  
  METHODS
  A total of 40 GDM and 240 normal glucose tolerance participants were enrolled at 24-28 weeks and completed the study. The clinical features, serum AFABP, other adipocytokines (leptin, adiponectin, retinol-binding protein 4), homeostasis model assessment of insulin resistance, and lipid profiles were measured in the second and third trimesters of pregnancy.
  
  
  RESULTS
  Compared with the normal glucose tolerance group, the GDM group showed greater levels of AFABP, leptin and retinol-binding protein 4; and a decreased level of adiponectin (P < 0.05 or P < 0.01) during mid- and late pregnancy periods. Prepregnancy body mass index was the independent factor impacting serum AFABP levels in the second (β = 0.567, P = 0.004) and third trimesters (β = 0.619, P = 0.001). Furthermore, GDM was independently associated with AFABP concentrations in multiple regression analysis in the second and third trimester (all P < 0.01). Serum AFABP, leptin and retinol-binding protein 4 are risk factors for GDM; adiponectin is a protective factor for GDM (P < 0.05 or P < 0.01).
  
  
  CONCLUSIONS
  The GDM group had a higher level of AFABP during mid- and late stages of pregnancy; prepregnancy body mass index and GDM were the independent factors with respect to serum AFABP. AFABP might be closely related to obesity, insulin resistance and leptin resistance in pregnancy, and is a major risk factor for GDM.
authors.affiliation: Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.|Key Laboratory for Major Obstetric Diseases of Guangdong Higher Education Institutes, Guangzhou, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Hao-Hang
authors.initials: HH
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Jia-Hui
authors.initials: JH
authors.lastname: Lu
authors.affiliation: Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Si-Yuan
authors.initials: SY
authors.lastname: Zheng
authors.affiliation: Department of Endocrinology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Long
authors.affiliation: Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Ying-Tao
authors.initials: YT
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Wei-Zhen
authors.initials: WZ
authors.lastname: Wu
authors.affiliation: Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
mesh_terms: D054392:Adipokines / Q000097:blood; D000328:Adult; D016640:Diabetes, Gestational / Q000097:blood*; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D050356:Lipid Metabolism; D011247:Pregnancy; D055815:Young Adult
chemical_list: D054392:Adipokines; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins
keywords: Adipocyte fatty acid binding protein; Adipocytokine; Gestational diabetes mellitus