title: New Concepts for Assessing Global Organ Function and Disease Activity Based on Combined PET and Structural Imaging Techniques.
abstract: This review is intended to discuss ways in which global and regional organ function may be assessed by using modern tomographic imaging methods. In addition, we discuss using (18)F-Fluorodeoxyglucose (FDG)-PET to monitor treatment response in various tumors as well as quantification of tumor burden in the entire body. We have selected FDG as a model that can also be adopted for other PET radiotracers. The merits of advanced quantitative measures for disease activity assessment in cancer and other disorders will also be addressed.
authors.affiliation: Department of Radiology, Division of Nuclear Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 1 Donner Building, Philadelphia, PA 19104-4283, USA.
authors.forename: Sandip
authors.initials: S
authors.lastname: Basu
authors.affiliation: Division of Nuclear Medicine, Geneva University Hospital, CH-1211 Geneva, Switzerland.
authors.forename: Habib
authors.initials: H
authors.lastname: Zaidi
authors.affiliation: Department of Radiology, Division of Nuclear Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 1 Donner Building, Philadelphia, PA 19104-4283, USA. Electronic address: abass.alavi@uphs.upenn.edu.
authors.forename: Abass
authors.initials: A
authors.lastname: Alavi