title: Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells.
abstract: Neural stem cells (NSCs) bear characteristics for proliferation, migration and differentiation into three main neural cell type(s): neurons, astrocytes and/or oligodendrocytes. Formylpeptide receptors (Fprs), belonging to the family of G protein-coupled chemoattractant receptors, have been detected on neurons in the central nervous system (CNS). Here, we report that Fpr1 and Fpr2 are expressed on NSCs as detected with immunohistochemistry, RT-PCR and WB assays. In addition, Fpr1 and Fpr2 promoted NSC migration through F-actin polymerization and skewed NSC differentiation to neurons. Our study demonstrates a unique role of Fpr1 and Fpr2 in NSCs and opens a novel window for cell replacement therapies for brain and spinal cord injury.
authors.affiliation: Department of Spine Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Guan
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Spine Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Spine Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Xingxing
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Spine Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Xue
authors.affiliation: Department of Pathology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
authors.forename: Qiaonan
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Spine Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Mingyong
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Spine Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D002478:Cells, Cultured; D058953:Neural Stem Cells / Q000166:cytology* / Q000378:metabolism*; D051381:Rats; D044042:Receptors, Formyl Peptide / Q000235:genetics / Q000378:metabolism*; D044067:Receptors, Lipoxin / Q000235:genetics / Q000378:metabolism*
chemical_list: D000199:Actins; C000626764:Fpr1 protein, rat; D044042:Receptors, Formyl Peptide; D044067:Receptors, Lipoxin; C482540:lipoxin A(4) receptor, rat