title: [Meta-analysis of the side-effect profiles of modern radiation therapies for patients with prostate cancer].
abstract: BACKGROUND
  One of the most relevant focus of recent developments in radiotherapy technology was the adequate irradiation of prostate cancer.
  
  
  OBJECTIVE
  The aim of this study was to analyse the safety of normo- and hypofractionated and high dose intensity-modulated radiotherapy.
  
  
  METHODS
  Toxicities were identified through literature review and evidence was synthetized with meta-analytical methods.
  
  
  RESULTS
  The use of high dose intensity-modulated radiotherapy resulted in no difference in severe genitourinary (acute p = 0.9; late p = 0.95) and moderate or severe gastrointestinal (acute: N/A; late: p = 0.08) toxicities compared to 3D conformal radiation therapy. The risk ratio of moderate acute (RR = 1.39, 95% CI: 1.09-1.78; p = 0.008) and late genitourinary toxicities (RR = 1.48, 95% CI: 1.26-1.75; p<0,00001) was higher. There was no difference in hypo- and normofractionated intensity-modulated radiotherapy regarding severe genitourinary (acute: N/A; late: p = 0.73) and moderate or severe gastrointestinal (acute: p = 0.73; late: p = 0.55) toxicities, the risk of late moderate genitourinary toxicities was higher when using hypofractionation scheme (RR = 1.39, 95% CI: 1.00-1.94; p = 0.05).
  
  
  CONCLUSIONS
  The use of normo- and hypofractionated and high dose intensity-modulated radiotherapy proved to be safe. However the higher risk of moderate genitourinary adverse events require an extensive clinical risk estimation.
authors.affiliation: Kancellária, Egészségügyi Gazdálkodási Igazgatóság, Pécsi Tudományegyetem Pécs, Rákóczi u. 2., 7633.|Egészségtudományi Kar, Egészségbiztosítási Intézet, Pécsi Tudományegyetem Pécs.
authors.forename: Antal Tamás
authors.initials: AT
authors.lastname: Zemplényi
authors.affiliation: Általános Orvostudományi Kar, Klinikai Központ, Onkoterápiás Intézet, Pécsi Tudományegyetem Pécs.
authors.forename: László
authors.initials: L
authors.lastname: Mangel
authors.affiliation: Egészség-gazdaságtani Kutatóközpont, Eötvös Loránd Tudományegyetem Budapest.|Syreon Kutató Intézet Budapest.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Kaló
authors.affiliation: Általános Orvostudományi Kar, Klinikai Központ, Pécsi Tudományegyetem.|Egészségtudományi Kar, Egészségbiztosítási Intézet, Pécsi Tudományegyetem Pécs.
authors.forename: Dóra
authors.initials: D
authors.lastname: Endrei
authors.affiliation: Klinikai Központ, Cochrane Hungary, Pécsi Tudományegyetem Pécs.
authors.forename: Szimonetta
authors.initials: S
authors.lastname: Lohner
authors.affiliation: Egészségtudományi Kar, Egészségbiztosítási Intézet, Pécsi Tudományegyetem Pécs.
authors.forename: Imre
authors.initials: I
authors.lastname: Boncz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019583:Dose Fractionation, Radiation; D041981:Gastrointestinal Tract / Q000528:radiation effects*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology*; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects; D014566:Urogenital System / Q000528:radiation effects*
keywords: dose hypofractionation; hipofrakcionálás; meta-analysis; metaanalízis; prostatic neoplasm; prosztatarák; radiotherapy; sugárterápia