title: The benefits of oxidative stress for tissue repair and regeneration.
abstract: Recent work has strengthened Drosophila imaginal discs as a model system for regeneration studies. Evidence is accumulating that oxidative stress drives the cellular responses for repair and regeneration. Drosophila imaginal discs generate a burst of reactive oxygen species (ROS) upon damage that is necessary for the activation of the Jun N-terminal kinase (JNK) and p38 MAP kinase signaling pathways. Moreover, these pathways are pivotal in the activation of regenerative growth. A hypothetical mechanism of how the ROS are initiated, and how repair and regeneration is activated is discussed here.
authors.affiliation: a Institute of Biomedicine of the University of Barcelona (IBUB) , Barcelona , Spain.|b Departament de Genètica, Facultat de Biologia , Universitat de Barcelona , Barcelona , Spain.
authors.forename: Florenci
authors.initials: F
authors.lastname: Serras
mesh_terms: D000818:Animals; D004330:Drosophila / Q000502:physiology*; D005786:Gene Expression Regulation; D020935:MAP Kinase Signaling System; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012038:Regeneration; D014945:Wound Healing
chemical_list: D017382:Reactive Oxygen Species
keywords: Drosophila; JNK; ROS; oxidative stress; p38; regeneration