title: Nanostructured lipid carriers, solid lipid nanoparticles, and polymeric nanoparticles: which kind of drug delivery system is better for glioblastoma chemotherapy?
abstract: BACKGROUND
  Glioblastoma is a malignant brain tumor originating in the central nervous system. Successfully therapy of this disease required the efficient delivery of therapeutic agents to the tumor cells and tissues. Delivery of anticancer drugs using novel nanocarriers is promising in glioma treatment.
  
  
  OBJECTIVE
  Polymeric nanoparticles (PNPs), solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs) were constructed for the delivery of temozolomide (TMZ). The anti-tumor effects of the three kinds of nanocarriers were compared to provide the optimum choice for gliomatosis cerebri treatment.
  
  
  METHODS
  TMZ-loaded PNPs (T-PNPs), SLNs (T-SLNs), and NLCs (T-NLCs) were formulated. Their particle size, zeta potential, drug encapsulation efficiency (EE), and drug loading (DL) capacity were evaluated. Anti-tumor efficacies of the three kinds of nanocarriers were evaluated on U87 malignant glioma cells (U87 MG cells) and mice-bearing malignant glioma model.
  
  
  RESULTS
  T-NLCs displayed the best anti-tumor activity than other formulations in vivo and in vitro. The most significantly glioma inhibition was observed on NLCs formulations than PNPs and SLNs.
  
  
  CONCLUSIONS
  This work demonstrates that NLCs can deliver TMZ into U87MG cells more efficiently, with higher inhibition efficacy than PNPs and SLNs. T-NLCs could be an excellent drug delivery system for glioblastoma chemotherapy.
authors.affiliation: a Department of Neurosurgery , Second Affiliated Hospital, Nanchang University , Nanchang , Jiangxi , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Qu
authors.affiliation: a Department of Neurosurgery , Second Affiliated Hospital, Nanchang University , Nanchang , Jiangxi , China.
authors.forename: Liangqiao
authors.initials: L
authors.lastname: Zhang
authors.affiliation: a Department of Neurosurgery , Second Affiliated Hospital, Nanchang University , Nanchang , Jiangxi , China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Chen
authors.affiliation: a Department of Neurosurgery , Second Affiliated Hospital, Nanchang University , Nanchang , Jiangxi , China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Mao
authors.affiliation: a Department of Neurosurgery , Second Affiliated Hospital, Nanchang University , Nanchang , Jiangxi , China.
authors.forename: Ziyun
authors.initials: Z
authors.lastname: Gao
authors.affiliation: a Department of Neurosurgery , Second Affiliated Hospital, Nanchang University , Nanchang , Jiangxi , China.
authors.forename: Xianliang
authors.initials: X
authors.lastname: Lai
authors.affiliation: a Department of Neurosurgery , Second Affiliated Hospital, Nanchang University , Nanchang , Jiangxi , China.
authors.forename: Xingen
authors.initials: X
authors.lastname: Zhu
authors.affiliation: a Department of Neurosurgery , Second Affiliated Hospital, Nanchang University , Nanchang , Jiangxi , China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry*; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003606:Dacarbazine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D005909:Glioblastoma / Q000188:drug therapy*; D006801:Humans; D008055:Lipids / Q000008:administration & dosage / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry*; D000077204:Temozolomide
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008055:Lipids; D011108:Polymers; D003606:Dacarbazine; D000077204:Temozolomide
keywords: Glioblastoma chemotherapy; nanostructured lipid carriers; polymeric nanoparticles; solid lipid nanoparticles; temozolomide