title: Novel therapy for anti-glomerular basement membrane disease with IgA nephropathy: A case report.
abstract: Anti-glomerular basement membrane (GBM) disease is characterized by circulating anti-GBM antibodies and deposition of these antibodies in the renal GBM. Renal involvement in anti-GBM is more severe when compared with other types of immune-mediated glomerulonephritis, and the majority of patients manifest progressive renal failure, leading to end-stage renal disease. In a limited number of cases, anti-GBM disease has been shown to be accompanied with other immune-mediated glomerulonephritis. The present study reported the case of a 50-year-old female patient presenting with rapidly progressive glomerulonephritis, who was diagnosed with anti-GBM disease with IgA nephropathy. The patient achieved a relatively good therapeutic outcome with administration of corticosteroids plus mycophenolate mofetil (MMF), which may prove to be a novel treatment option for this rare disease; however, the exact underlying mechanism requires further in-depth investigation.
authors.affiliation: Department of Medicine, Kidney Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
authors.forename: Dechao
authors.initials: D
authors.lastname: Xu
authors.affiliation: Department of Geriatrics, No. 411 Hospital of PLA, Shanghai 200081, P.R. China.
authors.forename: Jianxiang
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Medicine, Kidney Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Medicine, Kidney Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
authors.forename: Chenggang
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Medicine, Kidney Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Medicine, Kidney Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
authors.forename: Changlin
authors.initials: C
authors.lastname: Mei
authors.affiliation: Department of Medicine, Kidney Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
keywords: anti-glomerular basement membrane disease; immunoglobulin A nephropathy; mycophenolate mofetil