title: Osteoclast function and bone-resorbing activity: An overview.
abstract: Bone resorption is an important cellular function in skeletal development and remodeling of the adult skeleton. Most of the pathological bone disease conditions like osteoporosis reflect increased osteoclast activity; hence, increased bone resorption. Researchers have unraveled most of the intracellular mechanisms responsible for osteoclast bone-resorbing activity in last few decades. Therefore, understanding the fundamentals of osteoclast-induced bone resorption and the cytokines and other substances that modulate the osteoclast activity unequivocally provide insights into the development of drugs to ameliorate pathological bone diseases with enhanced bone resorption. The aim of this review is to examine the literature on osteoclast function and bone-resorbing activity.
authors.affiliation: Pharmacology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka. Electronic address: niroshanis@pdn.ac.lk.
authors.forename: Niroshani Surangika
authors.initials: NS
authors.lastname: Soysa
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Sri Lanka.
authors.forename: Neil
authors.initials: N
authors.lastname: Alles
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000378:metabolism / Q000473:pathology*; D002448:Cell Adhesion; D006801:Humans; D016023:Integrins / Q000032:analysis / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism / Q000473:pathology*; D000069261:Podosomes / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction
chemical_list: D016023:Integrins
keywords: Actin ring formation; Bone resorption; Osteoclast activity; Podosome