title: Immunological Reconstitution in Children After Completing Conventional Chemotherapy of Acute Lymphoblastic Leukemia is Marked by Impaired B-cell Compartment.
abstract: Humoral and cellular immunity were studied in 28 children completing conventional treatment of standard-risk (SR) or intermediate-risk (IR) acute lymphoblastic leukemia (ALL). Both naïve and memory B cells were most severely affected and showed slow recovery during the 2-year follow-up, while the T-cell compartment showed only minor changes. Immunoglobulins and IgG subclasses, components, and antibodies against vaccine-preventable diseases were not significantly affected. In conclusion, immune recovery after conventional chemotherapy for SR and IR ALL is marked by B-cell depletion, but otherwise did not show any severe deficiencies in lymphocyte function.
authors.affiliation: Division of Pediatric Hematology and Oncology, Department of Pediatrics, Turku University Hospital, University of Turku, Turku, Finland.|Division of Pediatric Hematology and Oncology and Stem Cell Transplantation, Department of Pediatrics, Children's Hospital, University of Helsinki, Helsinki, Finland.
authors.forename: Minna
authors.initials: M
authors.lastname: Koskenvuo
authors.affiliation: Immunogenetics Laboratory, University of Turku, Turku, Finland.
authors.forename: Ilse
authors.initials: I
authors.lastname: Ekman
authors.affiliation: Division of Pediatric Hematology and Oncology, Department of Pediatrics, Turku University Hospital, University of Turku, Turku, Finland.
authors.forename: Emmi
authors.initials: E
authors.lastname: Saha
authors.affiliation: Division of Pediatric Hematology and Oncology, Department of Pediatrics, Turku University Hospital, University of Turku, Turku, Finland.
authors.forename: Ellinoora
authors.initials: E
authors.lastname: Salokannel
authors.affiliation: Clinical Research Centre, Turku University Hospital, Turku, Finland.
authors.forename: Jaakko
authors.initials: J
authors.lastname: Matomäki
authors.affiliation: Immunogenetics Laboratory, University of Turku, Turku, Finland.
authors.forename: Jorma
authors.initials: J
authors.lastname: Ilonen
authors.affiliation: Division of Pediatric Hematology and Oncology, Department of Pediatrics, Turku University Hospital, University of Turku, Turku, Finland.
authors.forename: Leena
authors.initials: L
authors.lastname: Kainulainen
authors.affiliation: Division of Pediatric Hematology and Oncology, Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
authors.forename: Mikko
authors.initials: M
authors.lastname: Arola
authors.affiliation: Division of Pediatric Hematology and Oncology, Department of Pediatrics, Turku University Hospital, University of Turku, Turku, Finland.
authors.forename: Päivi Maria
authors.initials: PM
authors.lastname: Lähteenmäki
mesh_terms: D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003170:Complement Pathway, Alternative; D006801:Humans; D056724:Immunity, Humoral; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000276:immunology
keywords: B cell; T cell; chemotherapy; immune recovery; leukemia