title: NORAD: Defender of the Genome.
abstract: Long non-coding RNAs (lncRNAs) are a fascinating, but still largely uncharacterized, class of genes. A recent paper by the Mendell group identifies NORAD, a novel lncRNA that is regulated in response to DNA damage and plays a key role in maintaining genome integrity by modulating the activity the RNA binding proteins PUM2 and PUM1.
authors.affiliation: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, USA. Electronic address: venturaa@mskcc.org.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ventura
mesh_terms: D000595:Amino Acid Sequence / Q000235:genetics; D000818:Animals; D004249:DNA Damage / Q000235:genetics*; D016678:Genome; D006801:Humans; D008322:Mammals / Q000235:genetics; D062085:RNA, Long Noncoding / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*
chemical_list: C000607950:NORAD long non-coding RNA, human; C471242:PUM1 protein, human; C471243:PUM2 protein, human; D062085:RNA, Long Noncoding; D016601:RNA-Binding Proteins
keywords: CIN; NORAD; PUM1; PUM2; genomic stability; lncRNA