title: Neonatal hypoglycemic brain injury is a cause of infantile spasms.
abstract: Neonatal hypoglycemic brain injury is one of the causes of infantile spasms. In the present study, the clinical history and auxiliary examination results of 18 patients who developed infantile spasms several months after neonatal hypoglycemia were retrospectively analyzed. Among the 666 patients with infantile spasms admitted to two pediatric centers between January 2008 and October 2012, 18 patients developed infantile spasms after being diagnosed with neonatal hypoglycemia, defined as a whole blood glucose concentration of <2.6 mmol/l. These patients developed infantile spasms from between 2 and 10 months (mean, 4.9 months) following the diagnosis of neonatal hypoglycemia. All 18 patients had abnormal electroencephalographic findings with either classical or modified hypsarrhythmia. Upon examination using brain magnetic resonance imaging (MRI), 10 patients (55.6%) exhibited abnormalities. The MRI results principally showed a disproportional involvement of parietal and occipital cortices and sub-cortical white matter lesions. In conclusion, the results of this study indicate that neonatal hypoglycemic brain injury is associated with the subsequent development of infantile spasms.
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing 100853, P.R. China; Department of Pediatrics, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan 572013, P.R. China.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing 100853, P.R. China; Department of Neurology, Beijing Children's Hospital, The Capital Medical University, Beijing 100045, P.R. China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zou
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Xiuyu
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Tian
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ju
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Yao
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Liu
keywords: brain injury; etiology; infantile spasms; neonatal hypoglycemia