title: Antinociceptive effects of gentiopicroside on neuropathic pain induced by chronic constriction injury in mice: a behavioral and electrophysiological study.
abstract: Gentiopicroside (Gent) is promising as an important protective secoiridoid compound against pain. The present study was designed to investigate whether administration of Gent would alleviate the expression of nociceptive behaviors and whether it would cause the relevant electrophysiological changes in a chronic constriction injury (CCI) model of neuropathic pain in mice. Gent was administered from the seventh day after surgery for 8 consecutive days. Behavioral parameters and sciatic functional index were assessed immediately before surgery and on days 7, 8, 10, 12, and 14 post-CCI, and electrophysiological activities of sciatic nerve were recorded immediately after the behavioral test on the last day. The present study has shown that administration of Gent (at a dose of 50 and 100 mg/kg) increased behavioral parameters from day 8 compared with the CCI-NS group. Electrophysiological data indicated that CCI caused a significant reduction in nerve conduction velocities in the sciatic nerves and the amplitudes of compound action potential, while Gent at a dose of 50 or 100 mg/kg caused a significant recovery of electrophysiological changes induced by CCI. Our data indicated that Gent has antinociceptive effects on neuropathic pain induced by CCI.
authors.affiliation: a Department of Pharmacology, Ningxia Medical University, Yinchuan 750000, People's Republic of China.
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.affiliation: b College of Nursing, Ningxia Medical University, Yinchuan 750004, People's Republic of China.
authors.forename: Yu-Xiang
authors.initials: YX
authors.lastname: Li
authors.affiliation: a Department of Pharmacology, Ningxia Medical University, Yinchuan 750000, People's Republic of China.
authors.forename: Shuai-Shuai
authors.initials: SS
authors.lastname: Gong
authors.affiliation: a Department of Pharmacology, Ningxia Medical University, Yinchuan 750000, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.affiliation: a Department of Pharmacology, Ningxia Medical University, Yinchuan 750000, People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: c Luohe Medical College, Luohe 462002, Henan Province, People's Republic of China.
authors.forename: Shao-Ju
authors.initials: SJ
authors.lastname: Jin
authors.affiliation: d Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan 750000, People's Republic of China.
authors.forename: Cheng-Jun
authors.initials: CJ
authors.lastname: Zhao
authors.affiliation: e Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan 750004, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Niu
authors.affiliation: f Ningxia Key Lab of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan 750004, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Sun
authors.affiliation: a Department of Pharmacology, Ningxia Medical University, Yinchuan 750000, People's Republic of China.
authors.forename: Jian-Qiang
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D003250:Constriction; D004305:Dose-Response Relationship, Drug; D055724:Electrophysiological Phenomena / Q000187:drug effects* / Q000502:physiology; D057888:Iridoid Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D008124:Locomotion / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009437:Neuralgia / Q000188:drug therapy* / Q000503:physiopathology; D020426:Sciatic Neuropathy / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000700:Analgesics; D057888:Iridoid Glucosides; C012997:gentiopicroside
keywords: analgesia; analgésie; behavior; comportement; douleur neuropathique; electrophysiology; gentiopicroside; neuropathic pain; électrophysiologie