title: Highly enantioselective synthesis of dihydrocoumarin-fused dihydropyrans via the phosphine-catalyzed [4 + 2] annulation of allenones with 3-aroylcoumarins.
abstract: Phosphine-catalyzed [4 + 2] annulation between 3-aroylcoumarins and allenones has been developed. In the presence of a dipeptide phosphine catalyst 7, dihydrocoumarin-fused dihydropyrans were prepared in high yields and with excellent enantioselectivities.
authors.affiliation: Zhejiang Provincial Key Laboratory for Chemical & Biological Processing Technology of Farm Products, School of Biological and Chemical Engineering/School of Light Industry, Zhejiang University of Science and Technology, Hangzhou, 310023, China. chemhanxy@zust.edu.cn.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Han
authors.forename: Huanzhen
authors.initials: H
authors.lastname: Ni
authors.forename: Wai-Lun
authors.initials: WL
authors.lastname: Chan
authors.forename: Xikun
authors.initials: X
authors.lastname: Gai
authors.forename: Yongjiang
authors.initials: Y
authors.lastname: Wang
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lu
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003374:Coumarins / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003374:Coumarins; D007659:Ketones; D010720:Phosphines; D011714:Pyrans; C044646:phosphine