title: Isolated ACTH deficiency in a patient with empty sella as revealed by severe hyponatremia.
abstract: Hyponatremia due to isolated adrenocorticotropic hormone (ACTH) deficiency is difficult to diagnose as it is usually indistinguishable from non-endocrine syndrome of inappropriate antidiuretic hormone secretion (SIADH). We present a case secondary to empty sella. Most patients with empty sella remain asymptomatic throughout life and require no treatment; however, in cases involving the development of isolated ACTH deficiency, corticosteroid treatment should be enforced to avoid fatal consequences.
authors.affiliation: a Department of Internal Medicine , Grand Hopital de Charleroi , Charleroi , Belgium.
authors.forename: Nicoleta Alina
authors.initials: NA
authors.lastname: Doroftei
authors.affiliation: a Department of Internal Medicine , Grand Hopital de Charleroi , Charleroi , Belgium.
authors.forename: Catherine
authors.initials: C
authors.lastname: de Rudder
authors.affiliation: a Department of Internal Medicine , Grand Hopital de Charleroi , Charleroi , Belgium.
authors.forename: Nathalie
authors.initials: N
authors.lastname: de Visscher
authors.affiliation: b Department of Endocrinology , Grand Hopital de Charleroi , Charleroi , Belgium.
authors.forename: Francois
authors.initials: F
authors.lastname: Hanon
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000172:deficiency*; D000368:Aged; D004652:Empty Sella Syndrome / Q000150:complications* / Q000175:diagnosis; D004700:Endocrine System Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D030342:Genetic Diseases, Inborn / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D012964:Sodium / Q000097:blood*
chemical_list: D000324:Adrenocorticotropic Hormone; D012964:Sodium
keywords: ACTH deficiency; Empty sella; Hyponatremia; SIADH