title: The Role of Biomarkers in the Diagnosis and Risk Stratification of Acute Graft-versus-Host Disease: A Systematic Review.
abstract: Allogeneic hematopoietic cell transplantation (HCT) is an increasingly used curative modality for hematologic malignancies and other benign conditions. Attempts to reduce morbidity and mortality and improve survival in patients undergoing HCT are crucial. The ability to diagnose acute graft-versus-host disease (aGVHD) in a timely manner, or to even predict aGVHD before clinical manifestations, along with the accurate stratification of these patients, are critical steps to improve the treatment and outcomes of these patients. Many novel biomarkers that may help achieve these goals have been studied recently. This overview is intended to assist clinicians and investigators by providing a comprehensive review and analytical interpretation of the current knowledge concerning aGVHD and biomarkers likely to prove useful in diagnosis and risk stratification of this condition, along with the difficulties that hamper this approach.
authors.affiliation: Washington University School of Medicine, Department of Medicine, St. Louis, Missouri.
authors.forename: Alaa M
authors.initials: AM
authors.lastname: Ali
authors.affiliation: Washington University School of Medicine, Department of Medicine, St. Louis, Missouri.
authors.forename: John F
authors.initials: JF
authors.lastname: DiPersio
authors.affiliation: Washington University School of Medicine, Department of Medicine, St. Louis, Missouri. Electronic address: mschroed@dom.wustl.edu.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Schroeder
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000032:analysis; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D018570:Risk Assessment; D014184:Transplantation, Homologous
chemical_list: D015415:Biomarkers
keywords: Biomarker; Graft-versus-host disease; Hematopoietic stem cell transplantation; Proteomics