title: Multicenter Investigation of Gepotidacin (GSK2140944) Agar Dilution Quality Control Determinations for Neisseria gonorrhoeae ATCC 49226.
abstract: Gepotidacin, a novel triazaacenaphthylene antibacterial agent, is the first in a new class of type IIA topoisomerase inhibitors with activity against many biothreat and conventional pathogens, including Neisseria gonorrhoeae To assist ongoing clinical studies of gepotidacin to treat gonorrhea, a multilaboratory quality assurance investigation determined the reference organism (N. gonorrhoeae ATCC 49226) quality control MIC range to be 0.25 to 1 μg/ml (88.8% of gepotidacin MIC results at the 0.5 μg/ml mode).
authors.affiliation: JMI Laboratories, North Liberty, Iowa, USA ronald-jones@jmilabs.com.
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
authors.affiliation: JMI Laboratories, North Liberty, Iowa, USA.
authors.forename: Kelley A
authors.initials: KA
authors.lastname: Fedler
authors.affiliation: GlaxoSmithKline, Collegeville, Pennsylvania, USA.
authors.forename: Nicole E
authors.initials: NE
authors.lastname: Scangarella-Oman
authors.affiliation: JMI Laboratories, North Liberty, Iowa, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Ross
authors.affiliation: JMI Laboratories, North Liberty, Iowa, USA.
authors.forename: Robert K
authors.initials: RK
authors.lastname: Flamm
mesh_terms: D000073:Acenaphthenes / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006069:Gonorrhea / Q000382:microbiology*; D006575:Heterocyclic Compounds, 3-Ring / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D059003:Topoisomerase Inhibitors / Q000494:pharmacology*
chemical_list: D000073:Acenaphthenes; D000900:Anti-Bacterial Agents; D006575:Heterocyclic Compounds, 3-Ring; D059003:Topoisomerase Inhibitors; C000612856:gepotidacin