title: Near-infrared light triggered release of molecules from supramolecular hydrogel-nanorod composites.
abstract: To develop a stimulus-responsive material platform capable of releasing entrapped molecules in response to near infrared (NIR) light.
  
  
  
  Gold nanorods were mixed with hyaluronic acid derivatives modified with β-cyclodextrin or adamantane to create a NIR-responsive hydrogel-nanorod composite. Microfluidics were used to create responsive microgels and NIR-triggered release was evaluated.
  
  
  
  The hydrogel-nanorod composite material exhibited a rapid response to NIR-irradiation, allowing enhanced release of encapsulated payloads with material heating and network disruption. The release was dependent on the entrapped molecule size, the NIR exposure time and the light intensity.
  
  
  
  NIR irradiation of hydrogel-nanorods leads to plasmonic heating and triggered release of encapsulated molecules, a system that has potential for light-triggered release of therapeutics.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Highley
authors.affiliation: Department of Chemical & Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Miju
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Chemical & Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Daeyeon
authors.initials: D
authors.lastname: Lee
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Burdick
mesh_terms: D000218:Adamantane / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D006820:Hyaluronic Acid / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D007259:Infrared Rays; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D012212:Rheology; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D047392:beta-Cyclodextrins; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006046:Gold; D006820:Hyaluronic Acid; C031215:betadex; D000218:Adamantane
keywords: drug delivery; hydrogels; light; nanorods; stimuli