title: Cutaneous manifestations associated with melanoma.
abstract: Melanoma is a malignancy most commonly arising from the skin; therefore, primary melanoma characteristics are usually the first cutaneous manifestations of melanoma. Cutaneous metastases, which can occur locally or diffusely, are important to detect in a timely manner as treatments for advanced melanoma that impact survival are now available. Melanoma can be associated with local or diffuse pigmentation changes, including depigmentation associated with the leukodermas and hyperpigmentation associated with diffuse melanosis cutis. The leukodermas occur frequently, illustrate the immunogenic nature of melanoma, and may impact prognosis. Paraneoplastic syndromes in association with melanoma are rare, though can occur.
authors.affiliation: Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.
authors.forename: Ritva
authors.initials: R
authors.lastname: Vyas
authors.affiliation: Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Selph
authors.affiliation: Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH. Electronic address: Meg.Gerstenblith@uhhospitals.org.
authors.forename: Meg R
authors.initials: MR
authors.lastname: Gerstenblith
mesh_terms: D006801:Humans; D017495:Hyperpigmentation / Q000209:etiology / Q000473:pathology; D008545:Melanoma / Q000150:complications / Q000473:pathology*; D009364:Neoplasm Recurrence, Local; D010257:Paraneoplastic Syndromes; D010392:Pemphigus / Q000209:etiology / Q000473:pathology; D010859:Pigmentation Disorders / Q000209:etiology / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology* / Q000556:secondary; D014607:Uveomeningoencephalitic Syndrome / Q000209:etiology / Q000473:pathology
keywords: Cutaneous metastatic melanoma; Diffuse cutaneous melanosis; Leukoderma; Melanoma