title: Uterine serous carcinoma: a historic evaluation of therapy.
abstract: Summary
  
  
  OBJECTIVE
  Uterine serous carcinoma (USC) is an aggressive, histological subtype of endometrial cancer with a poor prognosis. This study evaluates the additional effect of staging surgery above total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH+BSO) on the use of adjuvant therapy and subsequent survival outcomes in clinical early-stage USC patients.
  
  
  METHODS
  This retrospective cohort study includes 75 women treated for clinical early-stage USC.
  
  
  RESULTS
  In 33 (44%) clinical early-stage patients surgical staging was performed and 15 patients (45%) proved to have lymphatic or abdominal metastasis. Use of adjuvant therapy was similar in patients, both staged with no metastasis (n = 18) and patients who underwent TAH and BSO only (n = 42, p = 0.17). No significant survival difference was found between surgically staged and TAH+BSO patients.
  
  
  CONCLUSIONS
  Surgical staging proved to be important to determine stage of disease and hence prognosis. Surgical staging did not lead to selective avoidance of adjuvant therapy in patients with no metastasis.
authors.forename: F a
authors.initials: Fa
authors.lastname: de Leeuw
authors.forename: F e m
authors.initials: Fe
authors.lastname: Rijcken
authors.forename: J w
authors.initials: Jw
authors.lastname: Trum
authors.forename: V
authors.initials: V
authors.lastname: van der Noort
authors.forename: R i
authors.initials: Ri
authors.lastname: Tjon-Kon-Fat
authors.forename: M c g
authors.initials: Mc
authors.lastname: Bleeker
authors.forename: G g
authors.initials: Gg
authors.lastname: Kenter
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D059186:Chemoradiotherapy, Adjuvant / Q000379:methods*; D017024:Chemotherapy, Adjuvant / Q000379:methods*; D015331:Cohort Studies; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D053208:Kaplan-Meier Estimate; D008197:Lymph Node Excision; D008875:Middle Aged; D009367:Neoplasm Staging; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000473:pathology / Q000628:therapy*; D010052:Ovariectomy / Q000379:methods*; D018714:Radiotherapy, Adjuvant / Q000379:methods*; D012189:Retrospective Studies; D058994:Salpingectomy / Q000379:methods*; D014594:Uterine Neoplasms / Q000473:pathology / Q000628:therapy