title: Chitosan/poly(vinyl alcohol)/bovine bone powder biocomposites: A potential biomaterial for the treatment of atopic dermatitis-like skin lesions.
abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects a large percent of the world́s population. This long-lasting skin disease has been treated by different approaches according to its causative agent and severity. Nonetheless, the use of advanced biomaterials to treat AD is poorly explored. The present study assessed the protective effectiveness of biocomposites films based on chitosan (Cs), poly(vinyl alcohol) (PVA) and bovine bone powder (BBP) on AD-like skin lesions. These original biocomposites were fully characterized and in vivo biological assays concerning the AD treatment were performed using a mouse model induced by 2,4-dinitrochlorobenzene (DNCB). The dorsal skin and ear of Balb/c female mice were challenging cutaneously with DNCB. Our findings demonstrate BBP-based biocomposite attenuated and treated considerably the DNCB-induced skin lesions in an AD-like model. In this sense, this study suggests that this original biocomposite may be applied as an active biomaterial for AD treatment.
authors.affiliation: Laboratório de Tecnologia e Desenvolvimento de Materiais Poliméricos e Compósitos (LaCoPol), Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
authors.forename: Nátali O
authors.initials: NO
authors.lastname: Alves
authors.affiliation: Laboratório de Tecnologia e Desenvolvimento de Materiais Poliméricos e Compósitos (LaCoPol), Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
authors.forename: Gabriela T
authors.initials: GT
authors.lastname: da Silva
authors.affiliation: Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
authors.forename: Douglas M
authors.initials: DM
authors.lastname: Weber
authors.affiliation: Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
authors.forename: Cristiane
authors.initials: C
authors.lastname: Luchese
authors.affiliation: Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
authors.forename: Ethel A
authors.initials: EA
authors.lastname: Wilhelm
authors.affiliation: Laboratório de Tecnologia e Desenvolvimento de Materiais Poliméricos e Compósitos (LaCoPol), Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil. Electronic address: andre.fajardo@pq.cnpq.br.
authors.forename: André R
authors.initials: AR
authors.lastname: Fajardo
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000627:therapeutic use*; D001688:Biological Products / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003876:Dermatitis, Atopic / Q000139:chemically induced / Q000628:therapy*; D003879:Dermatologic Agents / Q000737:chemistry / Q000627:therapeutic use; D004137:Dinitrochlorobenzene; D005260:Female; D051379:Mice; D008903:Minerals / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012867:Skin / Q000293:injuries
chemical_list: D001672:Biocompatible Materials; D001688:Biological Products; D003879:Dermatologic Agents; D004137:Dinitrochlorobenzene; D008903:Minerals; D011142:Polyvinyl Alcohol; D048271:Chitosan; C027762:bone meal
keywords: 2,4-Dinitrochlorobenzene (PubChem CID: 6); Acetic acid (PubChem CID: 176); Atopic dermatitis; Biocomposites; Bovine bone powder; Calcium chloride (PubChem CID: 5284359); Chitosan; Chitosan (PubChem CID: 3086191); Hydrochloric acid (PubChem CID: 313); Poly(vinyl alcohol) (PubChem CID: 11199); Serum albumin (PubChem CID: 16132389); Skin lesions; Sodium chloride (PubChem CID: 5234); Sodium tripolyphosphate (PubChem CID: 24455)