title: Vasorelaxant Effect of a Baccharis trimera Infusion on Precontracted Rat Aortic Rings.
abstract: Baccharis trimera (Less.) DC is a South American plant that in folk medicine is considered to produce reduction in blood pressure. One aspect of this putative effect is the vasorelaxation. The aim of this work was to evaluate the ability of a B. trimera extract to relax rat aortic rings precontracted with noradrenaline. As the infusion is the usual way of intake of this plant, an infusion of B. trimera was prepared using 100 g of the plant (leaves) boiled in water, frozen and lyophilized. Working solutions were prepared using different concentrations of the dried extract diluted in Krebs Henseleit solution. It was proved that the infusion relaxed the aortic rings in a dose dependent manner 100 minutes after adding the exract to the bath. Considering as 100% the maximum contraction achieved with noradrenaline, a relaxation of 101.1 ± 2.3% was observed with the highest dose of the infusion used in these experiments (0.32 mg/mL). While in control rings relaxation was 12.9 ± 2.4%. In aortic rings denuded from endothelium the percentage of vasoralaxation did not show statistically significant differences when compared to intact rings. These data support the hypothesis of a vasorelaxant effect of this plant and constitutes the first approach to the scientific basis of a potential antihypertensive effect.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Gómez
authors.forename: Ignacio
authors.initials: I
authors.lastname: Migues
authors.forename: Maria
authors.initials: M
authors.lastname: Caggiania
authors.forename: Ximena
authors.initials: X
authors.lastname: Arias
authors.forename: Mariajose
authors.initials: M
authors.lastname: Laprovitera
authors.forename: Fabiana
authors.initials: F
authors.lastname: Blanco
authors.forename: Maria Veronica
authors.initials: MV
authors.lastname: Cesio
authors.forename: Eduardo R
authors.initials: ER
authors.lastname: Migliaro
authors.forename: Horacio
authors.initials: H
authors.lastname: Heinzen
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects*; D031175:Baccharis / Q000737:chemistry*; D004730:Endothelium, Vascular / Q000187:drug effects; D051381:Rats; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents