title: Secular trends in the timing of skeletal maturation as assessed by the cervical vertebrae maturation method.
abstract: To investigate the presence of secular trends in skeletal maturation of girls and boys as assessed by the use of cervical vertebrae bones.
  
  
  
  The study compared two main groups: the first included data collected from the Denver growth study (1930s to 1960s) and the second included data collected from recent pretreatment records (1980s to 2010s) of patients from the orthodontic clinic of a North American University. The records from the two groups were all for Caucasian subjects. The sample for each group included 78 lateral cephalographs for girls and the same number for boys. The age of the subjects ranged from 7 to 18 years. Cervical vertebrae maturation (CVM) stages were directly assessed from the radiographs according to the method described by Hassel and Farman in which six CVM stages were designated from cervical vertebrae 2, 3, and 4.
  
  
  
  The mean age of girls from the Denver growth study and girls from the university clinic in each of the six CVM stages was not different at P ≤0.05. However, the mean age of boys from the two groups was not different only in stage 3 (P = 0.139) and stage 4 (P = 0.211).
  
  
  
  The results showed no evidence to indicate a tendency for earlier skeletal maturation of girls or boys. Boys in the university group started their skeletal maturation later than boys in the Denver group and completed their maturation earlier. Gender was a significant factor affecting skeletal maturation stages in both Denver and university groups.
authors.affiliation: Orthodontic Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt and.
authors.forename: Mona A
authors.initials: MA
authors.lastname: Montasser
authors.affiliation: Department of Orthodontics, University of Illinois at Chicago.
authors.forename: Grace
authors.initials: G
authors.lastname: Viana
authors.affiliation: Department of Orthodontics, University of Illinois at Chicago.
authors.forename: Carla A
authors.initials: CA
authors.lastname: Evans
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton / Q000379:methods*; D002508:Cephalometry / Q000379:methods; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging / Q000254:growth & development*; D002648:Child; D005260:Female; D005544:Forecasting; D006801:Humans; D008297:Male; D011859:Radiography / Q000379:methods; D015203:Reproducibility of Results; D012727:Sex Characteristics; D044465:White People