title: [Multifocal histoplasmosis due to Histoplasma capsulatum var. duboisii in a 22 year-old Senegalese patient without proven immunodepression].
abstract: The authors report a case of multifocal African histoplasmosis with polymorphic skin involvement occuring in a patient without proven immunosuppression. He was a young 22-year-old patient from eastern Senegal - but born in Ouganda - who presented with polymorphic skin lesions: ombilicated papulo-nodules, gums and ulcerative and budding lesions. He showed lymphadenopathies without clinical inflammation and with a cheesy appearance of the biopsy but without tuberculosis and also hepatosplenic and bone involvement. Mycological samples of the skin and lymph nodes biopsies revealed yeasts of Histoplasma capsulatum var. duboisii with a positive culture on Sabouraud medium. HIV serology, HTLV1et 2, the serum proteins electrophoresis were unremarkable. Treatment with amphotericin B was irregular because of its inaccessibility in the national territory and its cost. The patient died of sepsis together with the aggravation of his disease.
authors.affiliation: Service de dermatologie, l'hôpital Aristide-Le-Dantec, Dakar, Sénégal. Electronic address: diadie_saer@yahoo.fr.
authors.forename: S
authors.initials: S
authors.lastname: Diadie
authors.affiliation: Service de dermatologie, l'hôpital Aristide-Le-Dantec, Dakar, Sénégal. Electronic address: piscocomico@yahoo.fr.
authors.forename: B
authors.initials: B
authors.lastname: Diatta
authors.affiliation: Service de dermatologie, l'hôpital Aristide-Le-Dantec, Dakar, Sénégal. Electronic address: maodo7ndiaye@yahoo.fr.
authors.forename: M
authors.initials: M
authors.lastname: Ndiaye
authors.affiliation: Service d'anatomopathologie de l'hôpital Aristide-Le-Dantec, Dakar, Sénégal. Electronic address: gabdoumagib@yahoo.fr.
authors.forename: M
authors.initials: M
authors.lastname: Gaye
authors.affiliation: Service de parasitologie, CHNU Fann-Dakar, Dakar, Sénégal. Electronic address: doudsow@yahoo.fr.
authors.forename: D
authors.initials: D
authors.lastname: Sow
authors.affiliation: Service de dermatologie, l'hôpital Aristide-Le-Dantec, Dakar, Sénégal. Electronic address: mametene@gmail.com.
authors.forename: M T
authors.initials: MT
authors.lastname: Ndiaye
authors.affiliation: Service de dermatologie, l'hôpital Aristide-Le-Dantec, Dakar, Sénégal. Electronic address: tatabougoul@yahoo.fr.
authors.forename: B
authors.initials: B
authors.lastname: Seck
authors.affiliation: Service de dermatologie, l'hôpital Aristide-Le-Dantec, Dakar, Sénégal. Electronic address: mamoudousalamatou@yahoo.fr.
authors.forename: S
authors.initials: S
authors.lastname: Diallo
authors.affiliation: Service de dermatologie, l'hôpital Aristide-Le-Dantec, Dakar, Sénégal. Electronic address: asbindio@yahoo.fr.
authors.forename: A
authors.initials: A
authors.lastname: Diop
authors.affiliation: Service de dermatologie, l'hôpital Aristide-Le-Dantec, Dakar, Sénégal. Electronic address: moussante@yahoo.fr.
authors.forename: M
authors.initials: M
authors.lastname: Diallo
authors.affiliation: Service de dermatologie, l'hôpital Aristide-Le-Dantec, Dakar, Sénégal. Electronic address: lyfaty@yahoo.fr.
authors.forename: F
authors.initials: F
authors.lastname: Ly
authors.affiliation: Service de dermatologie, l'hôpital Aristide-Le-Dantec, Dakar, Sénégal. Electronic address: souzoumou@yahoo.fr.
authors.forename: S O
authors.initials: SO
authors.lastname: Niang
authors.affiliation: Service de dermatologie, l'hôpital Aristide-Le-Dantec, Dakar, Sénégal. Electronic address: askane@refer.sn.
authors.forename: A
authors.initials: A
authors.lastname: Kane
authors.affiliation: Service de dermatologie, l'hôpital Aristide-Le-Dantec, Dakar, Sénégal. Electronic address: mafath@sentoo.sn.
authors.forename: M T
authors.initials: MT
authors.lastname: Dieng
mesh_terms: D016469:Fungemia / Q000175:diagnosis / Q000382:microbiology; D006658:Histoplasma / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007121:Immunocompetence; D008297:Male; D012675:Senegal; D055815:Young Adult
keywords: African histoplasmosis; Disseminated disease; Histoplasma capsulatum var. duboisii; Histoplasmose africaine; Histoplasmose disséminée; Immune competence; Immunocompétence; Senegal; Sénégal