title: A randomized placebo-controlled study of preoperative pregabalin for postoperative analgesia in patients with spinal surgery.
abstract: OBJECTIVE
  To determine whether single preoperative administration of 2 different doses of pregabalin (75 and 150 mg) could decrease postoperative pain intensity and opioid consumption following posterior lumbar interbody fusion surgery.
  
  
  METHODS
  Prospective, randomized, active placebo-controlled, double-blinded study.
  
  
  METHODS
  Postoperative recovery area and patients' room.
  
  
  METHODS
  Ninety-seven adult, American Society of Anesthesiologists physical status 1 and 2 patients.
  
  
  METHODS
  Patients were randomly assigned to receive diazepam 5 mg as an active placebo (D5), pregabalin 75 mg (P75), or pregabalin 150 mg (P150). The study drug was orally administered 2 hours prior to surgery and a standard anesthetic technique was used. Postoperative pain was managed using intravenous patient-controlled analgesia with morphine.
  
  
  METHODS
  The visual analog scale at rest was used to measure pain intensity immediately after extubation at the postanesthesia care unit, and then 2, 4, 6, 12, 18, 24, 36, and 48 hours after surgery. Morphine consumption and adverse effects were assessed until 48 hours after surgery.
  
  
  RESULTS
  The visual analog scale score at rest was lower in the P150 group than in the D5 group until 2 hours after surgery. Morphine consumption was lower in the P150 group than in the D5 from 0 to 12 hours after surgery.
  
  
  CONCLUSIONS
  Single preoperative administration of 150 mg of pregabalin 2 hours prior to surgery reduced postoperative pain intensity and morphine consumption compared with 5 mg diazepam in patients who underwent posterior lumbar interbody fusion.
authors.affiliation: Department of Anesthesiology, Keiyu Orthopedic Hospital, 1741 Hanetsuku-cho, Tatebayashi, Gunma 374-0001, Japan.
authors.forename: Nao
authors.initials: N
authors.lastname: Fujita
authors.affiliation: Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Tobe
authors.affiliation: Department of Anesthesiology, Keiyu Orthopedic Hospital, 1741 Hanetsuku-cho, Tatebayashi, Gunma 374-0001, Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Tsukamoto
authors.affiliation: Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saito
authors.affiliation: Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan. Electronic address: hobata@gunma-u.ac.jp.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Obata
mesh_terms: D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D000069583:Pregabalin / Q000627:therapeutic use*; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies
chemical_list: D000700:Analgesics; D000069583:Pregabalin
keywords: Lumbar spinal surgery; Postoperative pain; Pregabalin