title: Elevated endocan concentration is associated with coronary slow flow.
abstract: We sought to assess whether serum endocan concentration is correlated with coronary slow flow (CSF). We measured serum endocan concentration in 93 patients with CSF and in 206 controls. Serum endocan concentration was measured by enzyme-linked immunosorbent assay (ELISA). The presence of CSF was assessed by thrombolysis in myocardial infarction (TIMI) frame count (TFC) method. We demonstrated that serum endocan concentration is significantly higher in CSF patients (n = 93) than that in controls (n = 206) (1.03 [range 0.63-1.33] vs. 0.80 [range 0.52-1.09] ng/mL, p = 0.002). Multivariate logistic regression analysis revealed that serum endocan concentration was independently associated with the presence of CSF (odds ratio 1.774, 95% confidence interval 1.064-2.958; p = 0.028). Serum endocan concentration was positively correlated with mean-TFC in CSF patients (r = 0.289, p = 0.005). These results revealed that endocan might be a useful biomarker for predicting the presence and severity of CSF. Therapeutic interventions by down-regulating endocan to delay the progressive process of CSF warrants further investigations.
authors.affiliation: a Department of Cardiology , Union Hospital, Fujian Medical University, and Fujian Institute of Coronary Artery Disease , Fuzhou , P. R. China.
authors.forename: Ming-Fang
authors.initials: MF
authors.lastname: Ye
authors.affiliation: a Department of Cardiology , Union Hospital, Fujian Medical University, and Fujian Institute of Coronary Artery Disease , Fuzhou , P. R. China.
authors.forename: Zi-Wen
authors.initials: ZW
authors.lastname: Zhao
authors.affiliation: a Department of Cardiology , Union Hospital, Fujian Medical University, and Fujian Institute of Coronary Artery Disease , Fuzhou , P. R. China.
authors.forename: Yu-Kun
authors.initials: YK
authors.lastname: Luo
authors.affiliation: a Department of Cardiology , Union Hospital, Fujian Medical University, and Fujian Institute of Coronary Artery Disease , Fuzhou , P. R. China.
authors.forename: Xian-Feng
authors.initials: XF
authors.lastname: Dong
authors.affiliation: a Department of Cardiology , Union Hospital, Fujian Medical University, and Fujian Institute of Coronary Artery Disease , Fuzhou , P. R. China.
authors.forename: Yuan-Ming
authors.initials: YM
authors.lastname: Yan
mesh_terms: D000368:Aged; D015415:Biomarkers; D001783:Blood Flow Velocity; D017023:Coronary Angiography; D003326:Coronary Circulation; D015536:Down-Regulation; D005260:Female; D006801:Humans; D008297:Male; D061185:Mechanical Thrombolysis; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000503:physiopathology; D009363:Neoplasm Proteins / Q000097:blood*; D011509:Proteoglycans / Q000097:blood*
chemical_list: D015415:Biomarkers; C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans
keywords: Coronary artery disease; biomarker; coronary slow flow; endocan; endothelial dysfunction