title: The incidence of Crohn's disease and ulcerative colitis since 1995 in Danish children and adolescents <17 years - based on nationwide registry data.
abstract: OBJECTIVE
  Worldwide the incidence of pediatric Crohn's disease (CD) and ulcerative colitis (UC) is suspected to be increasing. Based on unselected nationwide register data the aim of this study is to examine the change in incidence of CD and UC in children and adolescents in Denmark.
  
  
  METHODS
  All children and adolescents <17 years with a diagnosis of CD or UC registered in the Danish National Patient Registry from 1 January 1995 to 31 December 2013 were included. Using a Poisson regression model we estimated the incidence rate ratio (IRR) for the annual change in the incidence adjusted for gender and age. The cumulative incidence was described using Kaplan-Meier survival analyses.
  
  
  RESULTS
  The IRR for CD was 1.052 (95% CI: 1.039-1.065), and for UC the IRR was 1.022 (95% CI: 1.011-1.033), adjusted for age and gender. The incidence rate of CD increased during the study period to 10.0 (95% CI: 7.5-13.2) per 100,000 person years for girls and 9.4 (95% CI: 7.0-13.2) for boys, in 2013. Similar, the incidence of UC increased to 7.2 (95% CI: 5.0-9.9) per 100,000 person years for girls and 6.2 (95% CI: 4.3-8.7) for boys.
  
  
  CONCLUSIONS
  In a period of 19 years from 1995 to 2013 we found an increasing incidence for pediatric UC and CD, especially pronounced for CD.
authors.affiliation: a Research Unit of Clinical Epidemiology , Institute of Clinical Research, University of Southern Denmark , Odense , Denmark ;|b Center for Clinical Epidemiology , Odense University Hospital , Odense , Denmark ;
authors.forename: Michael Due
authors.initials: MD
authors.lastname: Larsen
authors.affiliation: a Research Unit of Clinical Epidemiology , Institute of Clinical Research, University of Southern Denmark , Odense , Denmark ;
authors.forename: Mira Eggebrecht
authors.initials: ME
authors.lastname: Baldal
authors.affiliation: c Hans Christian Andersen Children's Hospital, Odense University Hospital, and Research Unit of Pediatric , Institute of Clinical Research, University of Southern Denmark , Odense , Denmark.
authors.forename: Rasmus Gaardskær
authors.initials: RG
authors.lastname: Nielsen
authors.affiliation: a Research Unit of Clinical Epidemiology , Institute of Clinical Research, University of Southern Denmark , Odense , Denmark ;|b Center for Clinical Epidemiology , Odense University Hospital , Odense , Denmark ;
authors.forename: Jan
authors.initials: J
authors.lastname: Nielsen
authors.affiliation: b Center for Clinical Epidemiology , Odense University Hospital , Odense , Denmark ;
authors.forename: Ken
authors.initials: K
authors.lastname: Lund
authors.affiliation: a Research Unit of Clinical Epidemiology , Institute of Clinical Research, University of Southern Denmark , Odense , Denmark ;|b Center for Clinical Epidemiology , Odense University Hospital , Odense , Denmark ;
authors.forename: Bente Mertz
authors.initials: BM
authors.lastname: Nørgård
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000453:epidemiology*; D003424:Crohn Disease / Q000453:epidemiology*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010372:Pediatrics; D012042:Registries; D012044:Regression Analysis; D017678:Sex Distribution
keywords: Crohn’s disease; epidemiology; incidence; inflammatory bowel disease; ulcerative colitis