title: Long noncoding RNA ANRIL: a potential novel prognostic marker in cancer: a meta-analysis.
abstract: BACKGROUND
  Numerous researches have showed that the dysregulation of lncRNA ANRIL play a significant role in cancer progression, and high expression of ANRIL may have important clinical value. This meta-analysis aims to investigate potential clinical application role of ANRIL as a biomarker for cancer prognosis.
  
  
  METHODS
  The electronic search was conducted in Pubmed, EMBASE, Web of Science, CNKI and Wanfang database (up to January 27, 2016). We collected relevant articles to explore the association between the expression levels of ANRIL and overall survival (OS).
  
  
  RESULTS
  A total of 519 cancer patients from six studies were finally included. The results showed that cancer patients with high ANRIL expression may have a poorer OS (HR=1.95, 95%CI:1.37-2.53, P=0.000, fixed-effect model) than those with low ANRIL expression.
  
  
  CONCLUSIONS
  High expression of ANRIL is associated with poor clinical outcome. ANRIL might be act as a novel potential prognostic biomarker in various cancers.
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China - 479819035@qq.com.
authors.forename: Fang-Teng
authors.initials: FT
authors.lastname: Liu
authors.forename: Pei-Qian
authors.initials: PQ
authors.lastname: Zhu
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Luo
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Teng-Fei
authors.initials: TF
authors.lastname: Hao
authors.forename: Guang-Fei
authors.initials: GF
authors.lastname: Xia
authors.forename: Zheng-Ming
authors.initials: ZM
authors.lastname: Zhu
authors.forename: Cheng
authors.initials: C
authors.lastname: Qiu
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics / Q000401:mortality; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000401:mortality; D018450:Disease Progression; D019317:Evidence-Based Medicine; D005706:Gallbladder Neoplasms / Q000235:genetics / Q000401:mortality; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000401:mortality; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*; D012680:Sensitivity and Specificity; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; C561518:CDKN2B antisense RNA, human; D062085:RNA, Long Noncoding