title: Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis.
abstract: A new study has added loss of CD4(+) T cells caused by aberrant lipid metabolism to the list of mechanisms promoting nonalcoholic steatohepatitis progression to liver cancer (Ma et al., 2016). Exposure of CD4(+) T cells to free linoleic acid causes their ROS-mediated depletion, thereby favoring liver cancer growth.
authors.affiliation: Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
authors.forename: Shabnam
authors.initials: S
authors.lastname: Shalapour
authors.affiliation: Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: karinoffice@ucsd.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Karin
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D063646:Carcinogenesis / Q000378:metabolism* / Q000473:pathology*; D005227:Fatty Acids / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000473:pathology*; D008822:Mice, Transgenic; D008954:Models, Biological; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D005227:Fatty Acids