title: Co-expression network analysis prioritizes signaling pathways regulating liver regeneration after partial hepatectomy in rats.
abstract: The liver has extraordinary powers of regeneration following partial hepatectomy (PH). Changes in gene expression levels play a key role in cell proliferation and differentiation during liver regeneration (LR). To understand the molecular mechanisms underlying LR, this study was designed to assess the time-dependent changes in rat hepatic gene expression. We obtained a gene expression profile of rat LR with high temporal resolution. We then constructed gene co-expression networks of regenerating liver tissue and identified 13 LR-specific modules from 1772 differentially expressed genes, and prioritized signaling pathways that regulated LR after PH. The results indicated that adipocytokine signaling, histone acetylation, and IL-6-related pathways play an important role in LR. Co-expression network analysis provides novel insight into understanding the molecular mechanisms behind LR.
authors.affiliation: Engineering Technology Research Center for Computing Intelligence & Data Mining, College of Computer and Information Engineering, Henan Normal University, Xinxiang, Henan, China.|Key Laboratory of Cell Differentiation and Regulation, College of Life Science, Henan Normal University, Xinxiang, Henan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Engineering Technology Research Center for Computing Intelligence & Data Mining, College of Computer and Information Engineering, Henan Normal University, Xinxiang, Henan, China.
authors.forename: J C
authors.initials: JC
authors.lastname: Xu
authors.affiliation: Key Laboratory of Cell Differentiation and Regulation, College of Life Science, Henan Normal University, Xinxiang, Henan, China.
authors.forename: C S
authors.initials: CS
authors.lastname: Xu
mesh_terms: D000818:Animals; D053263:Gene Regulatory Networks; D006498:Hepatectomy; D006657:Histones / Q000235:genetics / Q000378:metabolism; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D008099:Liver / Q000378:metabolism* / Q000502:physiology / Q000601:surgery; D008115:Liver Regeneration; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D059467:Transcriptome
chemical_list: D006657:Histones; D015850:Interleukin-6