title: Time-programmed release of fluoroscein isocyanate dextran from micro-pattern-designed polymer scrolls.
abstract: In this article we present a relevant strategy for a non-trivial time-programmed release of water-soluble macromolecules from biocompatible μ-containers. The system is based on self-scrolled chitosan acetate (CA) fibers, encapsulated in a poly(dimethylsiloxane) matrix. Mass transfer between a fiber and the external environment takes place via the only opened extremity of the fiber. Fluoroscein isocyanate dextran (FID) is initially deposited at the inner surface of the CA fiber according to a programmed pattern. The FID molecules became mobile after the arriving of the swelling front, which propagates along the fiber's axis upon the immersion of the system in aqueous solution. Diffusion of the macromolecules into the environment is enabled by the open-tube geometry of the swollen part of the fiber, while a programmed kinetics of the drug release is due to patterning of the polymer film prior to rolling. The release of the macromolecules can be retarded by a few hours according to the placement of the FID spot with respect to the fibers orifice. A pulsatile release kinetics is demonstrated for a discrete pattern. A few millimeter spacing of the FID spots results in a few hours time interval between the release impulses. Random walk model is plugged in the effective diffusion coefficient for Fick's law and the release kinetics are simulated.
authors.affiliation: Institut de Science des Matériaux de Mulhouse, UMR 7361, CNRS-Université de Haute-Alsace, 15, rue Jean Starcky, Mulhouse 68057, France.
authors.forename: Aleksandr I
authors.initials: AI
authors.lastname: Egunov
authors.affiliation: Industrial Research Institute of Shizuoka Prefecture, 2078 Makigaya, Aoi-ku, Shizuoka 421-1298, Japan.
authors.forename: Ayano
authors.initials: A
authors.lastname: Inaba
authors.affiliation: Institut de Science des Matériaux de Mulhouse, UMR 7361, CNRS-Université de Haute-Alsace, 15, rue Jean Starcky, Mulhouse 68057, France.
authors.forename: Simon
authors.initials: S
authors.lastname: Gree
authors.affiliation: Institut de Science des Matériaux de Mulhouse, UMR 7361, CNRS-Université de Haute-Alsace, 15, rue Jean Starcky, Mulhouse 68057, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Malval
authors.affiliation: Industrial Research Institute of Shizuoka Prefecture, 2078 Makigaya, Aoi-ku, Shizuoka 421-1298, Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Tamura
authors.affiliation: The University of Tokyo, Department of Global Agricultural Sciences, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Yukie
authors.initials: Y
authors.lastname: Saito
authors.affiliation: Institut de Science des Matériaux de Mulhouse, UMR 7361, CNRS-Université de Haute-Alsace, 15, rue Jean Starcky, Mulhouse 68057, France. Electronic address: valeriy.luchnikov@uha.fr.
authors.forename: Valeriy A
authors.initials: VA
authors.lastname: Luchnikov
mesh_terms: D000085:Acetates / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D007700:Kinetics; D008962:Models, Theoretical
chemical_list: D000085:Acetates; D003692:Delayed-Action Preparations; D003911:Dextrans; D005456:Fluorescent Dyes; C015219:fluorescein isothiocyanate dextran; D048271:Chitosan; D016650:Fluorescein-5-isothiocyanate
keywords: ATR FTIR spectroscopy; Chitosan; Chronopharmacology; Controlled release; Fluoroscein isocyanate dextran; Macromolecule; Model drug