title: The Formation of Seven-Membered Heterocycles under Mild Pictet-Spengler Conditions: A Route to Pyrazolo[3,4]benzodiazepines.
abstract: Reported is a method for the synthesis of seven-membered heterocycles via a Pictet-Spengler condensation reaction under very mild conditions. High substrate scope allows for use of aldehydes using catalytic amounts of acetic acid yielding 39-90% and ketones using catalytic amounts of trifluoroacetic acid yielding 25-83%.
authors.affiliation: School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia.
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Katte
authors.affiliation: School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia.
authors.forename: Tristan A
authors.initials: TA
authors.lastname: Reekie
authors.affiliation: School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia.
authors.forename: William T
authors.initials: WT
authors.lastname: Jorgensen
authors.affiliation: School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Kassiou