title: Disrupted trabecular bone micro-architecture in middle-aged male HIV-infected treated patients.
abstract: HIV-infected individuals are at increased risk of incident fractures. Evaluation of trabecular bone micro-architecture is an important tool to assess bone strength, but its use has not yet been reported in middle-aged HIV-infected male individuals. The aim of the study was to compare bone micro-architecture between HIV-infected and HIV-uninfected men.
  
  
  
  In this cross-sectional study, 53 HIV-infected male individuals with a mean (± standard deviation) age of 49 ± 9 years who had been receiving antiretroviral therapy including tenofovir disoproxil fumarate (DF) for at least 60 months were compared with 50 HIV-uninfected male controls, matched for age and ethnic origin. We studied the volumetric bone density and micro-architecture of the radius and tibia using high-resolution peripheral quantitative computed tomography (HR-p QCT).
  
  
  
  Volumetric trabecular bone density was 17% lower in the tibia (P < 10(-4) ) and 16% lower in the radius (P < 10(-3) ) in HIV-infected patients compared with controls. By contrast, the cortical bone density was normal at both sites. The tibial trabecular micro-architecture differed markedly between patients and controls: bone volume/total volume (BV/TV) and trabecular number were each 13% lower (P < 10(-4) for both). Trabecular separation and inhomogeneity of the network were 18% and 24% higher in HIV-infected patients than in controls, respectively. The radial BV/TV and trabecular thickness were each 13% lower (P < 10(-3) and 10(-2) , respectively). Cortical thickness was not different between the two groups.
  
  
  
  The findings of lower volumetric trabecular bone density and disrupted trabecular micro-architectural parameters in middle-aged male HIV-infected treated patients help to explain bone frailty in these patients.
authors.affiliation: Department of Internal Medicine, Lariboisiere Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Sellier
authors.affiliation: INSERM U 606, Department of Rheumatology, Lariboisiere Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Ostertag
authors.affiliation: Laboratory of molecular biology, Lariboisiere Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Collet
authors.affiliation: Pharmacy, Lariboisiere Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Trout
authors.affiliation: Department of Internal Medicine, Lariboisiere Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
authors.forename: K
authors.initials: K
authors.lastname: Champion
authors.affiliation: INSERM U 606, Department of Rheumatology, Lariboisiere Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Fernandez
authors.affiliation: Department of Internal Medicine, Lariboisiere Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Lopes
authors.affiliation: Department of Internal Medicine, Lariboisiere Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Morgand
authors.affiliation: Department of Internal Medicine, Lariboisiere Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Clevenbergh
authors.affiliation: Department of Internal Medicine, Lariboisiere Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Evans
authors.affiliation: Department of Internal Medicine, Lariboisiere Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Souak
authors.affiliation: INSERM U 606, Department of Rheumatology, Lariboisiere Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
authors.forename: M-C
authors.initials: MC
authors.lastname: de Vernejoul
authors.affiliation: Department of Internal Medicine, Lariboisiere Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
authors.forename: J-F
authors.initials: JF
authors.lastname: Bergmann
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D015519:Bone Density; D001847:Bone Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D000071556:Cancellous Bone / Q000473:pathology*; D003430:Cross-Sectional Studies; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011884:Radius / Q000473:pathology; D000068698:Tenofovir / Q000627:therapeutic use; D013977:Tibia / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D044966:Anti-Retroviral Agents; D000068698:Tenofovir
keywords: HIV-infected men; bone micro-architecture; high-resolution peripheral quantitative computed tomography