title: Nuclear Architecture: Past and Future Tense.
abstract: The architecture of the interphase nucleus remains a treasure trove for explorers of the 3D folding of macromolecules, like DNA, and of their related functions. Only recently has there been insight into how transient interactions of the genome and its associated proteins, in space and time, facilitate transcription, replication, and repair.
authors.affiliation: Friedrich Miescher Institute for Biomedical Research Maulbeerstrasse 66 CH-4058 Basel Switzerland; Faculty of Natural Sciences, University of Basel CH-4056 Basel Switzerland. Electronic address: susan.gasser@fmi.ch.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Gasser
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D016678:Genome; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism
chemical_list: D009687:Nuclear Proteins; D004247:DNA