title: Detection of Gold Nanoparticles in Rat Organs by Transmission Electron Microscopy.
abstract: The effects of water-dispersed gold nanoparticles (8.0±0.9 nm in diameter) on the rat small intestinal mucosa and Peyer plaques, liver, and spleen were studied by electron microscopy. Water-dispersed gold nanoparticles injected into isolated intestinal loop not only accumulated in the small intestinal mucosa and Peyer plaques, but also penetrated into other organs, e.g. liver and spleen. Ultrastructural changes in the cells (hyperplasia of endoplasmic reticulum) were detected in the studied organs.
authors.affiliation: A. N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Platonova
authors.affiliation: A. N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia.
authors.forename: S M
authors.initials: SM
authors.lastname: Pridvorova
authors.affiliation: A. N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Zherdev
authors.affiliation: Research Institute of Nutrition, Moscow, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Gmoshinskii
authors.affiliation: Research Institute of Nutrition, Moscow, Russia.
authors.forename: L S
authors.initials: LS
authors.lastname: Vasilevskaya
authors.affiliation: A. N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia. dzantiev@inbi.ras.ru.
authors.forename: B B
authors.initials: BB
authors.lastname: Dzantiev
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000473:pathology; D006046:Gold / Q000493:pharmacokinetics / Q000633:toxicity*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D053768:Metal Nanoparticles / Q000633:toxicity*; D046529:Microscopy, Electron, Transmission; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D014018:Tissue Distribution
chemical_list: D006046:Gold
keywords: electron microscopy; gold nanoparticles; rat organ tissues