title: LEVOMILNACIPRAN--A SUCCESSOR OF MILNACIPRAN WITH A HIGHER NORADRENERGIC SELECTIVITY.
abstract: A new antidepressant, levomilnacipran, is the levorotatory enantiomer of milnacipran. The drug belongs to selective serotonin-norepinephrine reuptake inhibitors (SNRI) and has the highest noradrenergic selectivity of all members of this group of antidepressants. Clinical trials have confirmed the effectiveness of levomilnacipran in the treatment of depression. The drug was placed on the US market in the form of prolonged-release capsules, which greatly simplifies the treatment of psychiatric patients. The safety of the drug is also higher than the safety of a racemate, resulting in a beneficial impact on the therapeutic effect. In this paper we present current information on the pharmacological and clinical properties of the newest antidepressant--levomilnacipran.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Zadka
authors.forename: Ewelina
authors.initials: E
authors.lastname: Dziwota
authors.forename: Marcin
authors.initials: M
authors.lastname: Olajossy
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D003521:Cyclopropanes / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D015195:Drug Design; D006801:Humans; D000078764:Milnacipran; D015394:Molecular Structure; D000068760:Serotonin and Noradrenaline Reuptake Inhibitors / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D013329:Structure-Activity Relationship; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D003521:Cyclopropanes; D000068760:Serotonin and Noradrenaline Reuptake Inhibitors; D000078764:Milnacipran