title: RETRACTED: USP1 Regulates Cellular Senescence by Controlling Genomic Integrity.
abstract: This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).
  
  This article has been retracted at the request of the authors.
  
  We, the authors, were made aware of irregularities associated in western blots shown in our article. We have further investigated the matter and found that the paper contains multiple examples of incorrect data use and image flipping in four figures, including the vertical flipping and reuse of the panel in Figures 1B and 3D, similar flipping and incorrect blot image in Figure 2C, and incorrect data use in Figure 4A. All of these figures were assembled by the corresponding author (O.B.) who takes full responsibility for the inaccuracies. Under these circumstances, we believe that the most responsible course of action is to retract the paper. We sincerely apologize to the scientific community for any inconvenience resulting from the publication and retraction of this manuscript.
authors.affiliation: Institut Pasteur, Laboratory of Nuclear Organization and Oncogenesis, Department of Cell Biology and Infection, 75015 Paris, France; INSERM, U993, 75015 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer, 14 rue Corvisart, 75013 Paris, France.
authors.forename: Müge
authors.initials: M
authors.lastname: Ogrunc
authors.affiliation: Institut Pasteur, Laboratory of Nuclear Organization and Oncogenesis, Department of Cell Biology and Infection, 75015 Paris, France.
authors.forename: Ricardo Ivan
authors.initials: RI
authors.lastname: Martinez-Zamudio
authors.affiliation: Institute de Médecine Régénératrice et Biothérapies (IRMB), Université de Montpellier, CHU Montpellier, Hopital Saint-Eloi, 34295 Montpellier, France; INSERM U1183 Team "Genome and Stem Cell Plasticity in Development and Aging" Equipe Labellisée Ligue contre le Cancer, 80 rue Augustin Fliche, 34295 Montpellier, France.
authors.forename: Paul Ben
authors.initials: PB
authors.lastname: Sadoun
authors.affiliation: Institut Pasteur, Laboratory of Nuclear Organization and Oncogenesis, Department of Cell Biology and Infection, 75015 Paris, France.
authors.forename: Gregory
authors.initials: G
authors.lastname: Dore
authors.affiliation: Institute de Médecine Régénératrice et Biothérapies (IRMB), Université de Montpellier, CHU Montpellier, Hopital Saint-Eloi, 34295 Montpellier, France; INSERM U1183 Team "Genome and Stem Cell Plasticity in Development and Aging" Equipe Labellisée Ligue contre le Cancer, 80 rue Augustin Fliche, 34295 Montpellier, France.
authors.forename: Helene
authors.initials: H
authors.lastname: Schwerer
authors.affiliation: Institute of Human Genetics, UPR 1142, Centre National de la Recherche Scientifique (CNRS), 141 rue de la Cardonille, 34396 Montpellier, France; Equipe Labellisée Ligue Contre le Cancer, 14 rue Corvisart, 75013 Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Pasero
authors.affiliation: Institute de Médecine Régénératrice et Biothérapies (IRMB), Université de Montpellier, CHU Montpellier, Hopital Saint-Eloi, 34295 Montpellier, France; INSERM U1183 Team "Genome and Stem Cell Plasticity in Development and Aging" Equipe Labellisée Ligue contre le Cancer, 80 rue Augustin Fliche, 34295 Montpellier, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Lemaitre
authors.affiliation: Institut Pasteur, Laboratory of Nuclear Organization and Oncogenesis, Department of Cell Biology and Infection, 75015 Paris, France; INSERM, U993, 75015 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer, 14 rue Corvisart, 75013 Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Dejean
authors.affiliation: Institut Pasteur, Laboratory of Nuclear Organization and Oncogenesis, Department of Cell Biology and Infection, 75015 Paris, France; INSERM, U993, 75015 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer, 14 rue Corvisart, 75013 Paris, France. Electronic address: oliver.bischof@pasteur.fr.
authors.forename: Oliver
authors.initials: O
authors.lastname: Bischof
mesh_terms: D059447:Cell Cycle Checkpoints / Q000187:drug effects; D018797:Cell Cycle Proteins / Q000378:metabolism; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D016922:Cellular Senescence / Q000187:drug effects / Q000235:genetics*; D002843:Chromatin / Q000378:metabolism; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D015536:Down-Regulation / Q000187:drug effects; D052236:Fanconi Anemia Complementation Group D2 Protein / Q000378:metabolism; D020868:Gene Silencing / Q000187:drug effects; D042822:Genomic Instability / Q000187:drug effects; D006801:Humans; D016685:Mitomycin / Q000494:pharmacology; D009857:Oncogenes; D066329:Protein Aggregates / Q000187:drug effects; D011485:Protein Binding / Q000187:drug effects; D013312:Stress, Physiological / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D064570:Ubiquitin-Specific Proteases / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D002843:Chromatin; D050759:Cyclin-Dependent Kinase Inhibitor p21; D052236:Fanconi Anemia Complementation Group D2 Protein; D066329:Protein Aggregates; D016159:Tumor Suppressor Protein p53; D016685:Mitomycin; C579228:USP1 protein, human; D064570:Ubiquitin-Specific Proteases