title: What is the concentration of hydrogen peroxide in blood and plasma?
abstract: The concentration of hydrogen peroxide (H2O2) in blood and plasma is a measurement that has often been made, but the absolute values remain unsettled due the great variability of results actually published in the literature. As in every tissue, the concentration of H2O2 in blood and plasma is determined by the dynamics of its production versus its removal. The major sources of H2O2 in cells will only be briefly described as they are already well documented, The production of H2O2 in red blood cells will be described as it is less well known. But, the concentration of H2O2 within cells is more problematic. Intracellular H2O2 concentration has been estimated based on the kinetics of production and elimination, while its determination is technically difficult. Furthermore, compartmentalization and gradients result in its quantitation only as an average. The sources of extracellular H2O2, particularly in plasma, will also be described briefly. The major question addressed here however, is the actual concentration of H2O2 in plasma, which has been studied extensively, but still remains controversial.
authors.affiliation: Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, The University of Southern California, Los Angeles, CA 90089-0191, USA.
authors.forename: Henry Jay
authors.initials: HJ
authors.lastname: Forman
authors.affiliation: Baxter Healthcare Corporation, Baxter International, Deerfield, IL 60015, USA.
authors.forename: Angelito
authors.initials: A
authors.lastname: Bernardo
authors.affiliation: Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, The University of Southern California, Los Angeles, CA 90089-0191, USA; Division of Molecular & Computational Biology, Department of Biological Sciences, of the Dornsife College of Letters, Arts, & Sciences, The University of Southern California, Los Angeles, CA 90089-0191, USA. Electronic address: kelvin@usc.edu.
authors.forename: Kelvin J A
authors.initials: KJ
authors.lastname: Davies
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000737:chemistry*; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood*; D007700:Kinetics; D010949:Plasma / Q000737:chemistry*; D051381:Rats; D012016:Reference Values
chemical_list: D006861:Hydrogen Peroxide
keywords: Blood; Free radicals; Hydrogen peroxide; Oxidases; Oxidation; Plasma