title: Do surface-based match solution-based techniques? The case of drug-liposome interaction.
abstract: The aim of the study is to check if the information about drug/liposome interactions provided by Surface Plasmon Resonance (SPR) is comparable with that provided by potentiometry in which liposomes are not immobilized on a solid support. To reach our aim we apply QSPR and BR analysis to data extracted from the literature and carefully inspected for their reliability. Results show that log KD (SPR) is governed by a different balance of intermolecular interactions than log Dlip (potentiometry).
authors.affiliation: Molecular Biotechnology and Health Sciences Dept., Università degli Studi di Torino, via Quarello 15, 10135 Torino, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ermondi
authors.affiliation: Molecular Biotechnology and Health Sciences Dept., Università degli Studi di Torino, via Quarello 15, 10135 Torino, Italy. Electronic address: giulia.caron@unito.it.
authors.forename: Giulia
authors.initials: G
authors.lastname: Caron
mesh_terms: D008081:Liposomes / Q000737:chemistry*; D015233:Models, Statistical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011199:Potentiometry; D020349:Surface Plasmon Resonance
chemical_list: D008081:Liposomes; D004364:Pharmaceutical Preparations
keywords: Block relevance analysis; Lipophilicity; Liposomes; Potentiometry; Quantitative Structure-Property Relationship (QSPR); Surface Plasmon Resonance (SPR)