title: Zebrafish Melanoma.
abstract: Melanoma skin cancer is a potentially deadly disease in humans and has remained extremely difficult to treat once it has metastasized. In just the last 10 years, a number of models of melanoma have been developed in the zebrafish that are biologically faithful to the human disease and have already yielded important insights into the fundamental biology of melanoma and offered new potential avenues for treatment. With the diversity and breadth of the molecular genetic tools available in the zebrafish, these melanoma models will continue to be refined and expanded upon to keep pace with the rapidly evolving field of melanoma biology.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave., Boston, MA, 02115-5450, USA. ckkaufman@partners.org.|Boston Children's Hospital, Hematology/Oncology, Boston, MA, USA. ckkaufman@partners.org.
authors.forename: Charles K
authors.initials: CK
authors.lastname: Kaufman
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008545:Melanoma / Q000235:genetics / Q000473:pathology*; D015027:Zebrafish
keywords: Cancer models; Drug discovery; Melanoma; Transgenics; Zebrafish