title: Diarylpentanol constituents from the aerial part of Stelleropsis tianschanica.
abstract: Five diarylpentanol derivatives including two new compounds stellerasme A (1), stellerasme B (2) were isolated from the aerial parts of Stelleropsis tianschanica. Their structures were elucidated by various spectroscopic techniques (UV, IR, MS, CD, 1D and 2D NMR). All compounds were evaluated for their cytotoxicity activity against HeLa and KB cell lines, and compound 1 showed selective activities against HeLa cell line with an IC50 value of 7.4 μM.
authors.affiliation: a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education , Institute of Medicinal Plant Development , Beijing 100193 , China.|b Department of Natural Medicinal Chemistry , Xinjiang Institute of Chinese and Ethnic Medicine , Urumqi 830002 , China.
authors.forename: Lei-Ling
authors.initials: LL
authors.lastname: Shi
authors.affiliation: a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education , Institute of Medicinal Plant Development , Beijing 100193 , China.|b Department of Natural Medicinal Chemistry , Xinjiang Institute of Chinese and Ethnic Medicine , Urumqi 830002 , China.
authors.forename: Guo-Xu
authors.initials: GX
authors.lastname: Ma
authors.affiliation: d School of Pharmaceutical Sciences , Xiamen University , Xiamen 361102 , China.
authors.forename: Hua-Chun
authors.initials: HC
authors.lastname: Gao
authors.affiliation: d School of Pharmaceutical Sciences , Xiamen University , Xiamen 361102 , China.
authors.forename: Quan-Cheng
authors.initials: QC
authors.lastname: Chen
authors.affiliation: a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education , Institute of Medicinal Plant Development , Beijing 100193 , China.
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Yang
authors.affiliation: b Department of Natural Medicinal Chemistry , Xinjiang Institute of Chinese and Ethnic Medicine , Urumqi 830002 , China.
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Jia
authors.affiliation: c College of Chinese Medicinal Material , Jilin Agricultural University , Changchun 130118 , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D010420:Pentanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry*; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D010420:Pentanes; C000613868:stellerasme A; C000613869:stellerasme B
keywords: Stelleropsis tianschanica; Thymelaeaceae; cytotoxic activity; diarylpentanol derivatives