title: Correlation of Fractional Anisotropy With Motor Recovery in Patients With Stroke After Postacute Rehabilitation.
abstract: To investigate the relation between fractional anisotropy (FA), a suggested biomarker for tissue integrity, and motor recovery in patients with stroke after postacute rehabilitation.
  
  
  
  Retrospective study.
  
  
  
  Acute rehabilitation hospital.
  
  
  
  Subjects (N=43) diagnosed with ischemic stroke (n=28) and hemorrhagic stroke (n=15). The average age for subjects was 68±14 years.
  
  
  
  Magnetic resonance imaging and diffusion tensor imaging were conducted on all patients.
  
  
  
  The admission and discharge motor subscores of the FIM were obtained from medical records, and relative gain was calculated using the Montebello Rehabilitation Factor Score (MRFS). K-means cluster analysis (K=3) using both the MRFS and the gain of the FIM motor subscore (ΔFIM) was performed. Analysis of variance was used to determine the difference in FA among the clusters. Spearman analysis was conducted to examine the relation between FA, ΔFIM, and MRFS in each cluster.
  
  
  
  FA was significantly higher in the clusters of good and moderate recovery in the corticospinal tract (CST), peduncle, and posterior limb of the internal capsule bilaterally (all P<.05) compared with the poor recovery group. Significant positive correlations were observed in multiple regions along the CST between FA, ΔFIM, and MRFS in the clusters of good and moderate recovery, but not in the poor recovery group.
  
  
  
  Our results showed an association between FA values within the corticospinal tract and motor recovery in patients with stroke undergoing postacute rehabilitation. This finding may help to identify novel targets for new interventions to promote stroke recovery.
authors.affiliation: Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA; Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wen
authors.affiliation: Transcend Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA.
authors.forename: Mohamad J
authors.initials: MJ
authors.lastname: Alshikho
authors.affiliation: Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA; Department of Rehabilitation Medicine, Nan'ao People's Hospital of Shenzhen, The First Affiliated Hospital, Shenzhen University, Shenzhen, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Rehabilitation Medicine, Nan'ao People's Hospital of Shenzhen, The First Affiliated Hospital, Shenzhen University, Shenzhen, China; Kerry Rehabilitation Medicine Research Institute, Shenzhen, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA.
authors.forename: Ross
authors.initials: R
authors.lastname: Zafonte
authors.affiliation: Transcend Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA.
authors.forename: Martha R
authors.initials: MR
authors.lastname: Herbert
authors.affiliation: Stroke Biological Recovery Laboratory, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA. Electronic address: wang.qingmei@mgh.harvard.edu.
authors.forename: Qing Mei
authors.initials: QM
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016880:Anisotropy; D015415:Biomarkers; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D011379:Prognosis; D011712:Pyramidal Tracts / Q000000981:diagnostic imaging / Q000503:physiopathology*; D020127:Recovery of Function / Q000502:physiology*; D012047:Rehabilitation Centers; D012189:Retrospective Studies; D000071939:Stroke Rehabilitation / Q000379:methods*
chemical_list: D015415:Biomarkers
keywords: Diffusion tensor imaging; Rehabilitation; Stroke