title: Anti-biofilm Properties of Peganum harmala against Candida albicans.
abstract: OBJECTIVE
  Vaginitis still remains as a health issue in women. It is notable that Candida albicans producing biofilm is considered a microorganism responsible for vaginitis with hard to treat. Also, Peganum harmala was applied as an anti fungal in treatment for many infections in Iran. Therefore, this study goal to investigate the role of P. harmala in inhibition of biofilm formation in C. albicans.
  
  
  METHODS
  So, 27 C. albicans collected from women with Vaginitis, then subjected for biofilm formation assay. P. harmala was applied as antibiofilm formation in C. albicans.
  
  
  RESULTS
  Our results demonstrated that P. harmala in concentration of 12 μg/ml easily inhibited strong biofilm formation; while the concentrations of 10 and 6 μg/ml inhibited biofilm formation in moderate and weak biofilm formation C. albicans strains, respectively.
  
  
  CONCLUSIONS
  Hence, the current study presented P. harmala as antibiofilm herbal medicine for C. albicans; but in vivo study suggested to be performed to confirm its effectiveness.
authors.affiliation: Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Aboualigalehdari
authors.affiliation: Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Nourkhoda
authors.initials: N
authors.lastname: Sadeghifard
authors.affiliation: Research Center & Department of Microbiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Morovat
authors.initials: M
authors.lastname: Taherikalani
authors.affiliation: Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Zaynab
authors.initials: Z
authors.lastname: Zargoush
authors.affiliation: Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Tahmasebi
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Badakhsh
authors.affiliation: Department of Biology, Faculty of Sciences, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Arman
authors.initials: A
authors.lastname: Rostamzad
authors.affiliation: Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Sobhan
authors.initials: S
authors.lastname: Ghafourian
authors.affiliation: Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Pakzad
keywords: Candida albicans; Peganum harmala; biofilm formation