title: The role of Onodi cells in sphenoiditis: results of multiplanar reconstruction of computed tomography scanning.
abstract: BACKGROUND
  Onodi cells are the most posterior ethmoid air cells and extend superolateral to the sphenoid sinus. These cells are also intimately related with the sphenoid sinus, optic nerve, and carotid artery. Radiologic evaluation is mandatory to assess for anatomic variations before any treatment modalities related to the sphenoid sinus.
  
  
  OBJECTIVE
  To evaluate the effect of Onodi cells on the frequency of sphenoiditis.
  
  
  METHODS
  A retrospective analysis was performed in 618 adult patients who underwent high-resolution computed tomography between January 2013 and January 2015. The prevalence of Onodi cells and sphenoiditis was evaluated. Whether the presence of Onodi cells leads to an increase in the prevalence of sphenoiditis was investigated.
  
  
  RESULTS
  Onodi cell positivity was observed in 326 of 618 patients and its prevalence was found to be 52.7%. In the study group, 60.3% (n=73) were ipsilaterally (n=21) or bilaterally (n=52) Onodi-positive, whereas 39.7% (n=48) were Onodi-negative (n=35) or only contralaterally Onodi-positive (n=13). Of the control group, 48.3% (n=240) were Onodi-positive and 51.7% (n=257) were Onodi negative. The co-existence of Onodi cells ipsilaterally was observed to increase the identification of sphenoiditis 1.5-fold, and this finding was statistically significant (p<0.05).
  
  
  CONCLUSIONS
  The prevalence of sphenoiditis appears to be higher in patients with Onodi cells. However, it is not possible to state that Onodi cells are the single factor that causes this disease. Further studies are needed to investigate contributing factors related to sphenoiditis.
authors.affiliation: Konya Education and Research Hospital, Department of Otolaryngology, Head, and Neck Surgery, Konya, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Senturk
authors.affiliation: Medical Faculty, Selçuk University, Department of Radiology, Konya, Turkey. Electronic address: dribrahimguler@gmail.com.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Guler
authors.affiliation: Konya Education and Research Hospital, Department of Otolaryngology, Head, and Neck Surgery, Konya, Turkey.
authors.forename: Isa
authors.initials: I
authors.lastname: Azgin
authors.affiliation: Konya Education and Research Hospital, Department of Otolaryngology, Head, and Neck Surgery, Konya, Turkey.
authors.forename: Engin Umut
authors.initials: EU
authors.lastname: Sakarya
authors.affiliation: Konya Education and Research Hospital, Department of Otolaryngology, Head, and Neck Surgery, Konya, Turkey.
authors.forename: Gultekin
authors.initials: G
authors.lastname: Ovet
authors.affiliation: Konya Education and Research Hospital, Department of Otolaryngology, Head, and Neck Surgery, Konya, Turkey.
authors.forename: Necat
authors.initials: N
authors.lastname: Alatas
authors.affiliation: Konya Education and Research Hospital, Department of Radiology, Konya, Turkey.
authors.forename: Ismet
authors.initials: I
authors.lastname: Tolu
authors.affiliation: Medical Faculty, Selçuk University, Department of Otolaryngology, Head, and Neck Surgery, Konya, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Erdur
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000502:physiology; D012189:Retrospective Studies; D015524:Sphenoid Sinusitis / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: Anatomic variation; Computed tomography; Célula de Onodi; Esfenoidite; Onodi cell; Sphenoiditis; Tomografia computadorizada; Variação anatômica