title: Plasma-soluble urokinase plasminogen activator receptor (suPAR) levels in Behçet's disease and correlation with disease activity.
abstract: BACKGROUND
  Soluble urokinase plasminogen activator receptor (suPAR), a new biomarker, is a soluble form of membrane-bound receptors secreted from different immune cells. The aim of the present study is to determine plasma suPAR levels in Behçet's disease and their correlation with disease activity.
  
  
  METHODS
  Thirty Behçet's disease patients determined according to the International Study Group criteria for Behçet's disease diagnosis and 41 healthy subjects were included in the present study. Micro-enzyme-linked immunosorbent assay was employed to obtain quantitative data. Data of both groups were statistically analyzed.
  
  
  RESULTS
  The comparison of C-reactive protein and suPAR plasma levels of the control and Behçet's disease group revealed statistically significant differences (respectively, P = 0.003 < 0.05 and P = 0.020 < 0.05). However, plasma suPAR levels related with disease activity revealed no statistically significant differences (P > 0.05).
  
  
  CONCLUSIONS
  The present study is the first study analyzing suPAR levels in Behçet's disease patients and their correlation with disease activity. However, further prospective studies with larger patient series using suPAR as a new plasma biomarker are required to diagnose and monitor Behcet's disease and to support the findings of the present study.
authors.affiliation: Department of Dermatology, Konya Training and Research Hospital, Konya, Turkey.
authors.forename: Gulcan
authors.initials: G
authors.lastname: Saylam Kurtipek
authors.affiliation: Department of Microbiology, Afyon Kocatepe University, Faculty of Medicine, Afyonkarahisar, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Kesli
authors.affiliation: Department of Dermatology, Selçuk University, Faculty of Medicine, Konya, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Tuncez Akyurek
authors.affiliation: Department of Biochemistry, Selçuk University, Faculty of Medicine, Konya, Turkey.
authors.forename: Fikret
authors.initials: F
authors.lastname: Akyurek
authors.affiliation: Department of Dermatology, Konya Training and Research Hospital, Konya, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Ataseven
authors.affiliation: Department of Biostatistics, 19 May University, Samsun, Turkey.
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Terzi
mesh_terms: D000328:Adult; D000368:Aged; D001528:Behcet Syndrome / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood*; D012720:Severity of Illness Index; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; C524898:PLAUR protein, human; D055293:Receptors, Urokinase Plasminogen Activator; D002097:C-Reactive Protein
keywords: Behçet's disease; C-reactive protein; inflammation; suPAR