title: Accuracy of intra-operative frozen section and its role in the diagnostic evaluation of ovarian tumors.
abstract: Summary
  
  
  OBJECTIVE
  This retrospective study was undertaken to evaluate the accuracy and role of intra-operative frozen section in the diagnosis of ovarian tumors.
  
  
  METHODS
  Retrospective study of 804 ovarian frozen section results between June 2010 and June 2014 was examined to determine the accuracy of frozen section diagnosis. The intra-operative frozen section diagnosis was compared with the permanent (paraffin) section and the overall accuracy, sensitivity, specificity, and positive and negative predictive values of the frozen section were studied.
  
  
  RESULTS
  The overall accuracy to determine the status of malignancy was 92.6%. There were 38 (7.4%) false negative and no false positive frozen section diagnoses.The sensitivity, specificity, and positive predictive and negative predictive values for benign ovarian tumors were 100.0%, 97.0%, 91.3%, and 100.0%, respectively; for borderline tumors they were 64.3%, 97.0%, 91.5%, and 94.0%, respectively, and for malignant tumors they were 90.0%, 100.0%, 100.0%, and 85.5%, respectively.
  
  
  CONCLUSIONS
  This study concluded that frozen section appears to be an adequate technique for the histopathological diagnosis of ovarian tumors, with some limitations observed among borderline and mucinous tumors.
authors.forename: A
authors.initials: A
authors.lastname: Abudukadeer
authors.forename: S
authors.initials: S
authors.lastname: Azam
authors.forename: B
authors.initials: B
authors.lastname: Zunong
authors.forename: A Zuoremu
authors.initials: AZ
authors.lastname: Mutailipu
authors.forename: B
authors.initials: B
authors.lastname: Huijun
authors.forename: L
authors.initials: L
authors.lastname: Qun
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015331:Cohort Studies; D004407:Dysgerminoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D018240:Endodermal Sinus Tumor / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D004715:Endometriosis / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D005260:Female; D005350:Fibroma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D005629:Frozen Sections; D006106:Granulosa Cell Tumor / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D006801:Humans; D007432:Intraoperative Period; D008875:Middle Aged; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D010048:Ovarian Cysts / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D010049:Ovarian Diseases / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D018310:Sertoli-Leydig Cell Tumor / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D013724:Teratoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D013798:Thecoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D055815:Young Adult