title: Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse.
abstract: In recent years, p53 was identified to regulate the expression of many miRNAs and was also regulated by miRNAs. In this paper, we found that miR-138 showed a pronounced increase after p53 activation in human non-small cell lung cancer (NSCLC) cells, which is mediated by p53 binding sites in the promoter region of its host gene, but this did not happen with rat and mouse cells. More interestingly, we found that p53 could be also regulated by miR-138 in mouse and rat cells, but not in the human NSCLC cells. Our results suggest the existence of species-specific differences of the regulations of miRNA against its targets and the regulations of miRNA itself by other proteins.
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Xueting
authors.initials: X
authors.lastname: Su
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Xingliang
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Ding
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Aixue
authors.initials: A
authors.lastname: Huang
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Xingfeng
authors.initials: X
authors.lastname: Ge
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Lvbin
authors.initials: L
authors.lastname: Hou
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Chaonan
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Leqiao
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Chenjun
authors.initials: C
authors.lastname: Bai
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Xuelian
authors.initials: X
authors.lastname: Shen
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Fang
authors.affiliation: Department of Cell Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Yuanlin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cell Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Otorhinolaryngological department, Haidian Section of Peking University third Hospital, Beijing 100080, China.
authors.forename: Hongru
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Interventional Radiology, General Hospital of Fuzhou, Fuzhou, China.
authors.forename: Hongwen
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Beijing 100850, China.
authors.forename: Ningsheng
authors.initials: N
authors.lastname: Shao
mesh_terms: D000818:Animals; D002460:Cell Line; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D051381:Rats; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: C546110:MIRN138 microRNA, human; C583174:MIRN138 microRNA, mouse; C581260:MIRN138 microRNA, rat; D035683:MicroRNAs; D016159:Tumor Suppressor Protein p53