title: Characterization of ICP Behavior in an Experimental Model of Hemorrhagic Stroke in Rats.
abstract: Intracranial pressure (ICP) monitoring is sometimes required in clinical pictures of stroke, as extensive intraparenchymal hematomas and intracranial bleeding may severely increase ICP, which can lead to irreversible conditions, such as dementia and cognitive derangement. ICP monitoring has been accepted as a procedure for the safe diagnosis of increased ICP, and for the treatment of intracranial hypertension in some diseases. In this work, we evaluated ICP behavior during the induction of an experimental model of autologous blood injection in rats, simulating a hemorrhagic stroke. Rats were subjected to stereotactic surgery for the implantation of a unilateral cannula into the left striatal region of the brain. Autologous blood was infused into the left striatal region with an automatic microinfusion pump. ICP monitoring was performed throughout the procedure of hemorrhagic stroke induction. Analyses consisted of short-time Fourier transform for ICP before and after stroke induction and the histological processing of the animals' brains. Short-time Fourier transform analysis demonstrated oscillations in the ICP frequency components throughout time after the microinjections compared with data before them. Histological analysis revealed neuropathological changes in the striatum in all microinjected animals.
authors.affiliation: Federal University of Sao Carlos, Joint Graduate Program in Physiological Sciences, PIPGCF. Rodovia Washington Luis, km 235, SP-310, CEP 13565-905, Sao Carlos, Sao Paulo, Brazil. danilo.cardim@gmail.com.
authors.forename: Danilo Augusto
authors.initials: DA
authors.lastname: Cardim
authors.affiliation: School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
authors.forename: Raquel Araújo
authors.initials: RA
authors.lastname: do Val da Silva
authors.affiliation: Physics Institute of Sao Carlos, University of Sao Paulo, Sao Carlos, Brazil.
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Cardim
authors.affiliation: Braincare Corp., SAPRA, Sao Carlos, Brazil.
authors.forename: Brenno Caetano Troca
authors.initials: BC
authors.lastname: Cabella
authors.affiliation: Braincare Corp., SAPRA, Sao Carlos, Brazil.
authors.forename: Gustavo Henrique
authors.initials: GH
authors.lastname: Frigieri
authors.affiliation: School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
authors.forename: Cecília Vidal
authors.initials: CV
authors.lastname: de Sousa Torres
authors.affiliation: Braincare Corp., SAPRA, Sao Carlos, Brazil.
authors.forename: Charles Chenwei
authors.initials: CC
authors.lastname: Wang
authors.affiliation: Braincare Corp., SAPRA, Sao Carlos, Brazil.
authors.forename: Rodrigo Albuquerque
authors.initials: RA
authors.lastname: de Pacheco Andrade
authors.affiliation: School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
authors.forename: Renata Caldo
authors.initials: RC
authors.lastname: Scandiuzzi
authors.affiliation: Braincare Corp., SAPRA, Sao Carlos, Brazil.
authors.forename: Ana Carolina Segato
authors.initials: AC
authors.lastname: Rizzatti
authors.affiliation: Braincare Corp., SAPRA, Sao Carlos, Brazil.
authors.forename: Yvonne Maria
authors.initials: YM
authors.lastname: Mascarenhas
authors.affiliation: School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
authors.forename: João Pereira
authors.initials: JP
authors.lastname: Leite
authors.affiliation: Physics Institute of Sao Carlos, University of Sao Paulo, Sao Carlos, Brazil.
authors.forename: Sérgio
authors.initials: S
authors.lastname: Mascarenhas
mesh_terms: D000818:Animals; D002543:Cerebral Hemorrhage / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D003342:Corpus Striatum / Q000473:pathology; D004195:Disease Models, Animal; D005583:Fourier Analysis; D006706:Homeostasis; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male; D008991:Monitoring, Physiologic; D051381:Rats; D017208:Rats, Wistar; D020521:Stroke / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*
keywords: ICP monitoring; Intracranial pressure; Rats; Stroke