title: Percutaneous Transluminal Angioplasty in Patients With Infrapopliteal Arterial Disease: Systematic Review and Meta-Analysis.
abstract: BACKGROUND
  Contemporary outcomes of percutaneous transluminal angioplasty for the treatment of infrapopliteal atherosclerotic lesions are not well characterized. Hence, a systematic review and meta-analysis was performed to determine the safety and effectiveness of this approach in patients with advanced below-the-knee arterial disease.
  
  
  RESULTS
  MEDLINE and EMBASE databases were searched for contemporary studies (2005-2015) on the effects of percutaneous transluminal angioplasty for the treatment of infrapopliteal lesions. A random effects meta-analysis model was used to analyze procedural (technical success, flow-limiting dissection, provisional stent placement) and long-term (primary patency, repeat revascularization, major amputation, all-cause mortality) outcomes. Ultimately, 52 studies encompassing 6769 patients with 9399 below-the-knee lesions were included in the analysis. Technical success was 91.1% (95% confidence interval [CI], 88.8-93.0), and the incidence of flow-limiting dissections and bailout stenting was 5.6% (95% CI, 3.2-9.8) and 9.1% (95% CI, 6.3-12.9), respectively. Outcomes at 1 year were primary patency, 63.1% (95% CI, 57.3-68.6); repeat revascularization, 18.2% (95% CI, 14.5-22.6); major amputation, 14.9% (95% CI, 12.3-18.0); and all-cause mortality, 15.1% (95% CI, 12.8-17.7). Significant heterogeneity and publication bias were observed for most percutaneous transluminal angioplasty outcomes.
  
  
  CONCLUSIONS
  Contemporary studies of the use of percutaneous transluminal angioplasty as primary treatment for patients with infrapopliteal arterial disease reveal suboptimal procedural and 1-year clinical outcomes.
authors.affiliation: From the Department of Medicine, Metro Health Hospital, Wyoming, MI (J.A.M., S.M.F., L.J.D.-S., F.A.S.); and Miller Scientific Consulting, Inc, Asheville, NC (L.E.M.). jihad.mustapha@metrogr.org.
authors.forename: J A
authors.initials: JA
authors.lastname: Mustapha
authors.affiliation: From the Department of Medicine, Metro Health Hospital, Wyoming, MI (J.A.M., S.M.F., L.J.D.-S., F.A.S.); and Miller Scientific Consulting, Inc, Asheville, NC (L.E.M.).
authors.forename: Sara M
authors.initials: SM
authors.lastname: Finton
authors.affiliation: From the Department of Medicine, Metro Health Hospital, Wyoming, MI (J.A.M., S.M.F., L.J.D.-S., F.A.S.); and Miller Scientific Consulting, Inc, Asheville, NC (L.E.M.).
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Diaz-Sandoval
authors.affiliation: From the Department of Medicine, Metro Health Hospital, Wyoming, MI (J.A.M., S.M.F., L.J.D.-S., F.A.S.); and Miller Scientific Consulting, Inc, Asheville, NC (L.E.M.).
authors.forename: Fadi A
authors.initials: FA
authors.lastname: Saab
authors.affiliation: From the Department of Medicine, Metro Health Hospital, Wyoming, MI (J.A.M., S.M.F., L.J.D.-S., F.A.S.); and Miller Scientific Consulting, Inc, Asheville, NC (L.E.M.).
authors.forename: Larry E
authors.initials: LE
authors.lastname: Miller
mesh_terms: D017130:Angioplasty; D006801:Humans; D058729:Peripheral Arterial Disease / Q000401:mortality / Q000601:surgery*; D011150:Popliteal Artery / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: angioplasty; meta-analysis; percutaneous; peripheral artery disease; peripheral vascular disease; systematic review