title: Sustained relief of pain from osteosynthesis surgery of rib fracture by using biodegradable lidocaine-eluting nanofibrous membranes.
abstract: Various effective methods are available for perioperative pain control in osteosynthesis surgery, but they are seldom applied intraoperatively. The aim of this study was to evaluate a biodegradable poly([d,l]-lactide-co-glycolide) (PLGA)/lidocaine nanofibrous membrane for perioperative pain control in rib fracture surgery. Scanning electron microscopy showed high porosity of the membrane, and an ex vivo high-performance liquid chromatography study revealed an excellent release profile for both burst and controlled release of lidocaine within 30days. Additionally, the PLGA/lidocaine nanofibrous membrane was applied in an experimental rabbit rib osteotomy model. Implantation of the membrane around the osteotomized rib during osteosynthesis surgery resulted in a significant increase in weight gain, food and water consumption, and daily activity compared to the study group without the membrane. In addition, all osteotomized ribs were united. Thus, application of the PLGA/lidocaine nanofibrous membrane may be effective for sustained relief of pain in oeteosynthesis surgery.
authors.affiliation: Department of Mechanical Engineering, Chang Gung University, Kweishan, Tao-Yuan, Taiwan; Department of Orthopedic Surgery, Musculoskeletal Research Center, Chang Gung Memorial Hospital, Kweishan, Tao-Yuan, Taiwan.
authors.forename: Yi-Hsun
authors.initials: YH
authors.lastname: Yu
authors.affiliation: Department of Mechanical Engineering, Chang Gung University, Kweishan, Tao-Yuan, Taiwan; Department of Orthopedic Surgery, Musculoskeletal Research Center, Chang Gung Memorial Hospital, Kweishan, Tao-Yuan, Taiwan.
authors.forename: Yung-Heng
authors.initials: YH
authors.lastname: Hsu
authors.affiliation: Department of Mechanical Engineering, Chang Gung University, Kweishan, Tao-Yuan, Taiwan; Department of Orthopedic Surgery, Musculoskeletal Research Center, Chang Gung Memorial Hospital, Kweishan, Tao-Yuan, Taiwan.
authors.forename: Ying-Chao
authors.initials: YC
authors.lastname: Chou
authors.affiliation: Department of Mechanical Engineering, Chang Gung University, Kweishan, Tao-Yuan, Taiwan.
authors.forename: Chin-Lung
authors.initials: CL
authors.lastname: Fan
authors.affiliation: Department of Orthopedic Surgery, Musculoskeletal Research Center, Chang Gung Memorial Hospital, Kweishan, Tao-Yuan, Taiwan.
authors.forename: Steve W N
authors.initials: SW
authors.lastname: Ueng
authors.affiliation: Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Tao-Yuan, Taiwan.
authors.forename: Yi-Chuan
authors.initials: YC
authors.lastname: Kau
authors.affiliation: Department of Mechanical Engineering, Chang Gung University, Kweishan, Tao-Yuan, Taiwan; Department of Orthopedic Surgery, Musculoskeletal Research Center, Chang Gung Memorial Hospital, Kweishan, Tao-Yuan, Taiwan. Electronic address: shihjung@mail.cgu.edu.tw.
authors.forename: Shih-Jung
authors.initials: SJ
authors.lastname: Liu
mesh_terms: D020341:Absorbable Implants; D000779:Anesthetics, Local / Q000008:administration & dosage*; D000818:Animals; D019344:Lactic Acid; D008012:Lidocaine / Q000008:administration & dosage*; D008567:Membranes, Artificial; D057139:Nanofibers; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D011100:Polyglycolic Acid; D011817:Rabbits; D012253:Rib Fractures / Q000150:complications*
chemical_list: D000779:Anesthetics, Local; D008567:Membranes, Artificial; D011100:Polyglycolic Acid; D019344:Lactic Acid; D008012:Lidocaine
keywords: Lidocaine; Nanobiomaterial; PLGA nanofibrous membrane; Perioperative pain control; Rib fracture