title: Serum uric acid level and left ventricular hypertrophy in elderly male patients with nonvalvular atrial fibrillation.
abstract: Recent studies have suggested that serum uric acid (SUA) induces oxidative stress and inflammation, which are involved in the mechanism of cardiac hypertrophy. In patients with atrial fibrillation (AF), comorbidity of left ventricular hypertrophy (LVH) exacerbates cardiac function. In this study, we investigated the association between SUA and cardiac hypertrophy in AF patients.
  
  
  
  Initially, 1296 consecutive elderly patients (age >60) with nonvalvular AF were retrospectively selected from the inpatient clinic between January 2012 and April 2015. Demographic, clinical, and echocardiographic characteristics were carefully recorded. The final study population was 577 patients. The mean SUA level was significantly higher in patients with LVH than those without LVH. Compared with the non-LVH group, the LVH group was older, had a higher percentage of female patients, and had lower hemoglobin levels and estimated glomerular filtration rates. Patients in the LVH group also had a higher rate of coronary heart disease and fewer had history of radiofrequency ablation compared with the non-LVH group. In the hyperuricemia group, B-type natriuretic peptide levels, left atrial diameter, left ventricular mass index, and percentage of NYHA (New York Heart Association) class III/IV were significantly higher than the SUA normal group. Multivariate logistic regression analysis indicated the independent risk factors for LVH in elderly AF patients included SUA, age, male sex, the presence of coronary heart disease, and diuretic therapy. Subgroup analysis identified SUA as a significant risk factor associated with LVH in men.
  
  
  
  SUA was independently associated with LVH in elderly male patients with nonvalvular AF.
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing, People's Republic of China.
authors.forename: W Y
authors.initials: WY
authors.lastname: Liang
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing, People's Republic of China.
authors.forename: W W
authors.initials: WW
authors.lastname: Liu
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing, People's Republic of China. Electronic address: meilinliu@yahoo.com.
authors.forename: M L
authors.initials: ML
authors.lastname: Liu
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing, People's Republic of China.
authors.forename: W
authors.initials: W
authors.lastname: Xiang
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing, People's Republic of China.
authors.forename: X R
authors.initials: XR
authors.lastname: Feng
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing, People's Republic of China.
authors.forename: B
authors.initials: B
authors.lastname: Huang
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing, People's Republic of China.
authors.forename: X H
authors.initials: XH
authors.lastname: Chen
authors.affiliation: Department of Geriatrics, Peking University First Hospital, Beijing, People's Republic of China.
authors.forename: Y S
authors.initials: YS
authors.lastname: Sun
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000150:complications* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D033461:Hyperuricemia / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D015854:Up-Regulation; D014527:Uric Acid / Q000097:blood*; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
chemical_list: D015415:Biomarkers; D014527:Uric Acid
keywords: Atrial fibrillation; Left ventricular hypertrophy; Serum uric acid