title: Multifunctional BSA-Au nanostars for photoacoustic imaging and X-ray computed tomography.
abstract: We report the synthesis and characterization of bovine serum albumin-capped Au nanostars (BSA-AuNSs) for dual-modal computed tomography (CT)/photoacoustic (PA) imaging application. The BSA-AuNSs have an average size of 85nm, and a surface plasmon resonance (SPR) peak at approximately 770nm. They have excellent biocompatibility, good X-ray attenuation, and great PA contrast enhancement properties. When injected intravenously, liver signal markedly increases in both CT and PA modalities. The in vivo biodistribution studies and pathology results showed that the BSA-AuNSs were mainly excreted through the liver and intestines with no obvious biotoxicity. These results indicate that BSA-AuNSs have high potential to be used as dual-modal CT/PA imaging contrast agents or further used to develop targeted probes. This preliminary study suggests that PA tomography may be used to non-invasively trace the kinetics and biodistribution of the nanoparticles.
authors.affiliation: Department of Radiology, China-Japan Union Hospital, Jilin University, Changchun, China.
authors.forename: Lihui
authors.initials: L
authors.lastname: Zu
authors.affiliation: Department of Radiology, China-Japan Union Hospital, Jilin University, Changchun, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.affiliation: Institute of Molecular Medicine, College of Life and Health Sciences, Northeastern University, Shenyang, China.
authors.forename: Yeshan
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Institute of Molecular Medicine, College of Life and Health Sciences, Northeastern University, Shenyang, China. Electronic address: simonliu@mail.neu.edu.cn.
authors.forename: Hongguang
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Radiology, China-Japan Union Hospital, Jilin University, Changchun, China. Electronic address: jlfs-yang@163.com.
authors.forename: Haishan
authors.initials: H
authors.lastname: Yang
mesh_terms: D000818:Animals; D003287:Contrast Media; D006046:Gold; D051379:Mice; D053758:Nanoparticles; D061088:Photoacoustic Techniques; D012710:Serum Albumin, Bovine; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D012710:Serum Albumin, Bovine; D006046:Gold
keywords: Au nanoparticles; Dual-modal imaging; Photoacoustic imaging; X-ray computed tomography