title: The pharmacology and therapeutic potential of (-)-huperzine A.
abstract: (-)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss. Due to its potent neuroprotective activities, it has been investigated as a candidate for the treatment of neurodegenerative diseases, including Alzheimer's disease. In this review, we will discuss the pharmacology and therapeutic potential of (-)-huperzine A (1). Synthetic studies of (-)-huperzine A (1) aimed at enabling its development as a pharmaceutical will be described.
authors.affiliation: Department of Chemistry, Yale University, New Haven, CT, USA.
authors.forename: Maung Kyaw Moe
authors.initials: MK
authors.lastname: Tun
authors.affiliation: Department of Chemistry, Yale University, New Haven, CT, USA.
authors.forename: Seth B
authors.initials: SB
authors.lastname: Herzon
keywords: Alzheimer’s; NMDA; natural products; neurodegeneration; synthesis