title: Intracellular Ca(2+) signaling and Ca(2+) microdomains in the control of cell survival, apoptosis and autophagy.
abstract: The endoplasmic reticulum (ER), mitochondria and lysosomes are physically and/or functionally linked, establishing close contact sites between these organelles. As a consequence, Ca(2+) release events from the ER, the major intracellular Ca(2+)-storage organelle, have an immediate effect on the physiological function of mitochondria and lysosomes. Also, the lysosomes can act as a Ca(2+) source for Ca(2+) release into the cytosol, thereby influencing ER-based Ca(2+) signaling. Given the important role for mitochondria and lysosomes in cell survival, cell death and cell adaptation processes, it has become increasingly clear that Ca(2+) signals from or towards these organelles impact these processes. In this review, we discuss the most recent insights in the emerging role of Ca(2+) signaling in cellular survival by controlling basal mitochondrial bioenergetics and by regulating apoptosis, a mitochondrial process, and autophagy, a lysosomal process, in response to cell damage and cell stress.
authors.affiliation: KU Leuven, Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 B-802, BE-3000 Leuven, Belgium.
authors.forename: Rita M L
authors.initials: RM
authors.lastname: La Rovere
authors.affiliation: KU Leuven, Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 B-802, BE-3000 Leuven, Belgium.
authors.forename: Gemma
authors.initials: G
authors.lastname: Roest
authors.affiliation: KU Leuven, Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 B-802, BE-3000 Leuven, Belgium. Electronic address: geert.bultynck@med.kuleuven.be.
authors.forename: Geert
authors.initials: G
authors.lastname: Bultynck
authors.affiliation: KU Leuven, Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, Campus Gasthuisberg O/N-1 B-802, BE-3000 Leuven, Belgium. Electronic address: jan.parys@med.kuleuven.be.
authors.forename: Jan B
authors.initials: JB
authors.lastname: Parys
mesh_terms: D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D002470:Cell Survival; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism*; D021962:Membrane Microdomains / Q000378:metabolism*
chemical_list: D002118:Calcium
keywords: Apoptosis; Autophagy; Endoplasmic reticulum; IP(3) receptor; Lysosomes; Mitochondria