title: Efficacy and safety of Qiaoshao Formula () on patients with lifelong premature ejaculation of Gan (Liver) depression and Shen (Kidney) deficiency syndrome: A randomized controlled trial.
abstract: OBJECTIVE
  To observe the effificacy and safety of Qiaoshao Formula (, QSF) on patients with lifelong premature ejaculation (LPE) of Gan (Liver) depression and Shen (Kidney) defificiency syndrome.
  
  
  METHODS
  A total of 60 LPE patients were randomly divided into treatment (QSF) and control (dapoxetine) groups. The treatment group received QSF twice a day and the control group received dapoxetine 1 to 2 h prior to planned sexual intercourse for 4 weeks. The outcomes included intra-vaginal ejaculation latency time (IELT), premature ejaculation diagnostic tool (PEDT), clinical global impression of change (CGIC), scores of Chinese medicine symptoms (CMSS), sex life satisfaction (SLS) and adverse events (AEs).
  
  
  RESULTS
  In the treated group, the median IELT was 3 min vs. 1.5 min before and after treatment (P<0.05). PEDT in the treated group was reduced to 11.76±1.68 from 15.83±2.30 after treatment (P<0.05). Besides, patient's SLS was improved from 1.30±0.05 to 6.30±0.04 (P<0.05), and spouse's SLS was increased from 1.30±0.to 6.10±0.06 (P<0.05); CMSS was decrease from 14.86±3.02 to 9.62±2.87 (P<0.05). In addition, no significant AE was observed in both groups.
  
  
  CONCLUSIONS
  QSF may be effective and safe on LPE patients with Gan depression and Shen defificiency syndrome.
authors.affiliation: Department of Andrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Andrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
authors.forename: Qing-He
authors.initials: QH
authors.lastname: Gao
authors.affiliation: Department of Andrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. fu311306@163.com.
authors.forename: Fu
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Andrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
authors.forename: Guo-Jin
authors.initials: GJ
authors.lastname: Yu
authors.affiliation: Department of Andrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
authors.forename: Ji-Wei
authors.initials: JW
authors.lastname: Zhang
authors.affiliation: Department of Andrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: Department of Andrology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Geng
authors.affiliation: Xiangya School of Medicine, Central South University, Changsha, 410013, China.
authors.forename: Bo-da
authors.initials: BD
authors.lastname: Guo
authors.affiliation: Department of Andrology, Beijing Traditional Chinese Medicine Hospital Affilliated to Capital Medical University, Beijing, 100010, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Han
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010549:Personal Satisfaction; D061686:Premature Ejaculation / Q000175:diagnosis / Q000188:drug therapy*; D013577:Syndrome; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Chinese medicine; Qiaoshao Formula; dapoxetine; intra-vaginal ejaculation latency time; lifelong premature ejaculation; premature ejaculation diagnostic tool