title: Can the histopathology influence the outcome of early-stage cervical cancer?
abstract: OBJECTIVE
  The assessment of the histology influence on survival in early-stage cervical cancer patients treated with surgery.
  
  
  METHODS
  The retrospective analysis of 71 cervical adenocarcinoma (AC), International Federation of Gynecology and Obstetrics (FIGO) Stage IB, treated initially with surgery, between 1989 and 1999 and 43 squamous cell cancer (SCC) patients, treated with the same method, between 1998 and 1999, was performed. Cox multi-variant analysis and the Kaplan-Meyer methods were performed (the level of statistical significance, p ≤ 0.05).
  
  
  RESULTS
  The ten-year overall survival (OS) of AC and SCC patients was 67.5% and 90%, p = 0.015. The ten-year disease free survival (DFS) was 63% and 85%, p = 0.022, respectively. After adjusting the significant prognostic factors, patients with AC had significantly worse treatment outcomes than patients with SCC: DFS (relative risk (RR) 1.85, 95% CI = 1.28-2.69, p = 0.001) and OS (RR 1.65, 95% CI = 1.65-2.33, p = 0.005).
  
  
  CONCLUSIONS
  Prognosis of early cervical AC patients, treated with surgery, appears to be less favorable as compared to patients with SCC, treated with the same method.
authors.forename: J
authors.initials: J
authors.lastname: Jonska-Gmyrek
authors.forename: A
authors.initials: A
authors.lastname: Zolciak-Siwinska
authors.forename: L
authors.initials: L
authors.lastname: Gmyrek
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000628:therapy; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007044:Hysterectomy; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D011878:Radiotherapy; D012189:Retrospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents