title: Tantalum implanted entangled porous titanium promotes surface osseointegration and bone ingrowth.
abstract: Porous Ti is considered to be an ideal graft material in orthopaedic and dental surgeries due to its similar spatial structures and mechanical properties to cancellous bone. In this work, to overcome the bioinertia of Ti, Ta-implanted entangled porous titanium (EPT) was constructed by plasma immersion ion implantation &deposition (PIII&D) method. Ca-implanted and unimplanted EPTs were investigated as control groups. Although no difference was found in surface topography and mechanical performances, both Ca- and Ta-implanted groups had better effects in promoting MG-63 cell viability, proliferation, differentiation, and mineralization than those of unimplanted group. The expression of osteogenic-related markers examined by qRT-PCR and western blotting was upregulated in Ca- and Ta-implanted groups. Moreover, Ta-implanted EPT group could reach a higher level of these effects than that of Ca-implanted group. Enhanced osseointegration of both Ca- and Ta-implanted EPT implants was demonstrated through in vivo experiments, including micro-CT evaluation, push-out test, sequential fluorescent labeling and histological observation. However, the Ta-implanted group possessed more stable and continuous osteogenic activity. Our results suggest that Ta-implanted EPT can be developed as one of the highly efficient graft material for bone reconstruction situations.
authors.affiliation: Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Mengqi
authors.initials: M
authors.lastname: Cheng
authors.affiliation: State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Guofeng
authors.initials: G
authors.lastname: Jiang
authors.affiliation: State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Guo
authors.initials: G
authors.lastname: He
authors.affiliation: Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Yunsu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Xianlong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Xuanyong
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D018786:Bone Substitutes; D002460:Cell Line; D006801:Humans; D008297:Male; D008422:Materials Testing; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D016062:Porosity; D019736:Prostheses and Implants; D011817:Rabbits; D013499:Surface Properties; D013635:Tantalum; D014025:Titanium; D055114:X-Ray Microtomography
chemical_list: D018786:Bone Substitutes; D013635:Tantalum; D014025:Titanium