title: False Lumen Status in Patients With Acute Aortic Dissection: A Systematic Review and Meta-Analysis.
abstract: The long-term association between the status of the false lumen and poor patient outcomes in acute aortic dissection (AAD) remains unclear. This systematic review and meta-analysis investigated whether the status of the false lumen was a predictor of poor long-term survival in AAD.
  
  
  
  Eleven cohort studies (2924 participants) exploring the association between the false lumen status and long-term outcomes (>1 year) in AAD were included. All studies reported multivariate-adjusted hazard ratios (HRs) with 95% CIs for long-term outcomes, according to false lumen status. Pooled HRs for mortality and aortic events were computed and weighted using generic inverse-variance and random-effect modeling. Residual patent false lumen was an independent predictor of long-term mortality in AAD type A (HR, 1.71; 95% CI, 1.16-2.52; P=0.007) and type B (HR, 2.79; 95% CI, 1.80-4.32; P<0.001). AAD patients with residual patent false lumen exhibited an increased risk of aortic events (HR, 5.43; 95% CI, 2.95-9.99; P<0.001). Partial false lumen thrombosis was independently associated with long-term mortality in type B AAD (HR, 2.24; 95% CI, 1.37-3.65; P=0.001). This association was not observed in AAD type A patients (HR, 1.75; 95% CI, 0.88-3.45; P=0.211).
  
  
  
  The false lumen status influences late outcomes in AAD. Residual patent false lumen is independently associated with poor long-term survival in AAD. However, only type B AAD patients with partial false lumen thrombosis had an increased late mortality risk.
authors.affiliation: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Dongze
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Ye
authors.affiliation: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Yarong
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Emergency Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Cao
authors.affiliation: Department of Emergency Medicine, Mianyang Central Hospital, Mianyang, China.
authors.forename: Jining
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Emergency Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Zhong
authors.affiliation: Department of Emergency Medicine, Zigong No. 4 People's Hospital, Zigong, China.
authors.forename: Linghong
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zeng
authors.affiliation: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China yuyuer@126.com 303680215@qq.com.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wan
authors.affiliation: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China yuyuer@126.com 303680215@qq.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cao
mesh_terms: D000784:Aortic Dissection / Q000453:epidemiology* / Q000401:mortality; D001014:Aortic Aneurysm / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D009026:Mortality; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D013927:Thrombosis / Q000453:epidemiology* / Q000401:mortality
keywords: aortic dissection; false lumen; meta‐analysis; thrombosis