title: DNA Binding, Cleavage and Antibacterial Activity of Mononuclear Cu(II), Ni(II) and Co(II) Complexes Derived from Novel Benzothiazole Schiff Bases.
abstract: A series of novel bivalent metal complexes M(L1)2 and M(L2)2 where M = Cu(II), Ni(II), Co(II) and L1 = 2-((benzo [d] thiazol-6-ylimino)methyl)-4-bromophenol [BTEMBP], L2 = 1-((benzo [d] thiazol-6-ylimino)methyl) naphthalen-2-ol [BTEMNAPP] were synthesized. All the compounds have been characterized by elemental analysis, SEM, Mass, (1)H NMR, (13)C NMR, UV-Vis, IR, ESR, spectral data and magnetic susceptibility measurements. Based on the analytical and spectral data four-coordinated square planar geometry is assigned to all the complexes. DNA binding properties of these complexes have been investigated by electronic absorption spectroscopy, fluorescence and viscosity measurements. It is observed that these binary complexes strongly bind to calf thymus DNA by an intercalation mode. DNA cleavage efficacy of these complexes was tested in presence of H2O2 and UV light by gel electrophoresis and found that all the complexes showed better nuclease activity. Finally the compounds were screened for antibacterial activity against few pathogens and found that the complexes have potent biocidal activity than their free ligands.
authors.affiliation: Department of Chemistry, Osmania University, Hyderabad, Telangana, -500007, India.
authors.forename: Narendrula
authors.initials: N
authors.lastname: Vamsikrishna
authors.affiliation: Department of Chemistry, Osmania University, Hyderabad, Telangana, -500007, India.
authors.forename: Marri Pradeep
authors.initials: MP
authors.lastname: Kumar
authors.affiliation: Department of Chemistry, Osmania University, Hyderabad, Telangana, -500007, India.
authors.forename: Somapangu
authors.initials: S
authors.lastname: Tejaswi
authors.affiliation: Department of Chemistry, Osmania University, Hyderabad, Telangana, -500007, India.
authors.forename: Aveli
authors.initials: A
authors.lastname: Rambabu
authors.affiliation: Department of Chemistry, Osmania University, Hyderabad, Telangana, -500007, India. shivaraj_sunny@yahoo.co.in.
authors.lastname: Shivaraj
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D052160:Benzothiazoles / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry; D004247:DNA / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects*; D009281:Naphthalenes / Q000737:chemistry; D009532:Nickel / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D052160:Benzothiazoles; D056831:Coordination Complexes; D009281:Naphthalenes; D012545:Schiff Bases; C031721:naphthalene; D003035:Cobalt; D003300:Copper; D009532:Nickel; D004247:DNA; C005465:benzothiazole
keywords: Antibacterial activity; Binary complex; DNA cleavage; Fluorescence; Schiff base; Viscosity measurements