title: Polymer-Chlorambucil Drug Conjugates: A Dynamic Platform of Anticancer Drug Delivery.
abstract: Recently, polymer drug conjugates (PDCs) have attracted considerable attention in the treatment of cancer. In this work, a simple strategy has been developed to make PDCs of an antitumor alkylating agent, chlorambucil, using a biocompatible disulphide linker. Chlorambucil-based chain transfer agent was used to prepare various homopolymers and block copolymers in a controlled fashion via reversible addition-fragmentation chain transfer polymerization. Chlorambucil conjugated block copolymer, poly(polyethylene glycol monomethyl ether methacrylate)-b-poly(methyl methacrylate), formed nanoaggregates in aqueous solutions, which are characterized by dynamic light scattering and field emission-scanning electron microscopy. Finally, the simplicity of the design is exemplified by performing a release study of chlorambucil under reducing condition by using D,L-dithiothreitol.
authors.affiliation: Department of Chemical Sciences, Polymer Research Centre, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741246, Nadia, West Bengal, India.
authors.forename: Biswajit
authors.initials: B
authors.lastname: Saha
authors.affiliation: Department of Chemical Sciences, Polymer Research Centre, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741246, Nadia, West Bengal, India.
authors.forename: Ujjal
authors.initials: U
authors.lastname: Haldar
authors.affiliation: Department of Chemical Sciences, Polymer Research Centre, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741246, Nadia, West Bengal, India.
authors.forename: Priyadarsi
authors.initials: P
authors.lastname: De
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry*; D002699:Chlorambucil / Q000737:chemistry*; D016503:Drug Delivery Systems; D011108:Polymers / Q000737:chemistry*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D011108:Polymers; D002699:Chlorambucil
keywords: RAFT polymerization; antitumor alkylating agents; chlorambucil; prodrugs; self-assembly