title: [Change of Serum Angiopoietin-related Growth Factor in Patients with Abdominal Aortic Aneurysm and Its Clinical Significance].
abstract: OBJECTIVE
  To investigate the changes and value of plasma angiopoietin-related growth factor (AGF) in patients with abdominal aortic aneurysm (AAA).
  
  
  METHODS
  Serum AGF level was analyzed in 50 AAA patients and in 56 healthy subjects. AGF and adiponectin were quantified by enzyme-linked immunosorbent assay. Routine testing of blood biochemistry and high-sensitivity C-reactive protein were performed.
  
  
  RESULTS
  The plasma AGF level was significantly higher in AAA patients than in the controls [(87.91±96.87) μg/L vs. (56.89±41.32) μg/L, P=0.040],while serum adiponectin level showed no significant difference between these two groups. The plasma AGF level in patients with an AAA>5 cm and those with AAA between 3 cm and 5 cm were (96.08±68.61) μg/L and (75.27±46.05) μg/L.
  
  
  CONCLUSIONS
  Plasma AGF is highly expressed in AAA patients. Higher serum AGF level is associates with larger AAA. Thus, AGF may be a potential serum biomarker for AAA.
authors.affiliation: Department of Vascular Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Hao
authors.initials: H
authors.lastname: Nie
authors.affiliation: Department of Vascular Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Vascular Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Hua-liang
authors.initials: HL
authors.lastname: Ren
authors.affiliation: Department of Vascular Surgery,the Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China.
authors.forename: Yue-wei
authors.initials: YW
authors.lastname: Wang
authors.affiliation: Department of Physiology and Physiopathology,Capital Medical University,Beijing 100069,China.
authors.forename: Cui
authors.initials: C
authors.lastname: Tian
authors.affiliation: Department of Physiology and Physiopathology,Capital Medical University,Beijing 100069,China.
authors.forename: Hui-hua
authors.initials: HH
authors.lastname: Li
authors.affiliation: Department of Vascular Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
authors.forename: Yue-hong
authors.initials: YH
authors.lastname: Zheng
mesh_terms: D052242:Adiponectin / Q000097:blood; D000091308:Angiopoietin-Like Protein 6; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins / Q000097:blood*; D017544:Aortic Aneurysm, Abdominal / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans
chemical_list: C477601:ANGPTL6 protein, human; D052242:Adiponectin; D000091308:Angiopoietin-Like Protein 6; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins; D015415:Biomarkers; D002097:C-Reactive Protein