title: Feasibility of data-driven cardiac respiratory motion correction of myocardial perfusion CZT SPECT: A pilot study.
abstract: We developed a data-driven respiratory motion (RM) correction method (REGAT program) for multiple-pinhole detector CZT SPECT. We verified its clinical feasibility with myocardial perfusion imaging (MPI) and studied its impact on image characteristics.
  
  
  
  This retrospective study included 18 patients having stress/rest99mTc-Tetrofosmin MPI SPECT. List mode was acquired on CZT SPECT and processed with REGAT. REGAT generates reconstructed RM-gated volumes that are summed either without realignment (NR-SPECT) or after realignment (R-SPECT). For both stress and rest, we calculated the maximal RM in the 3 axis, and image characteristics of both R-SPECT and NR-SPECT: minimum left ventricular (LV) cavity counts (LV-Min), maximum LV myocardial counts (LV-Max), LV contrast, and FWHM of both anterior (FWHM-ant) and inferior (FWHM-inf) LV myocardial walls.
  
  
  
  At both stress and rest, cranio-caudal motion was the dominant axial movement and REGAT had a positive impact on image characteristics as reflected by variations between R-SPECT and NR-SPECT in LV-Min, LV-Max, FWHM-ant, FWHM-inf, and contrast. These latter were well correlated to the amplitude of cranio-caudal motion at both stress and rest.
  
  
  
  Data-driven RM correction of MPI acquired with CZT SPECT is clinically feasible and easily applicable. It presents interesting impact on image characteristics.
authors.affiliation: EA 7334 REMES, Université Paris-Diderot, Sorbonne Paris-Cité, Paris, France. doumit.daou@cch.aphp.fr.|Nuclear Medicine Department, Cochin University Hospital, AP-HP, 27 rue du Faubourg Saint-Jacques, 75679, Paris Cedex 14, France. doumit.daou@cch.aphp.fr.
authors.forename: Doumit
authors.initials: D
authors.lastname: Daou
authors.affiliation: Nuclear Medicine Department, CHU Jean Minjoz, Besançon, France.
authors.forename: Rémy
authors.initials: R
authors.lastname: Sabbah
authors.affiliation: Nuclear Medicine Department, Centre Hospitalier de Bigorre, Tarbes, France.
authors.forename: Carlos
authors.initials: C
authors.lastname: Coaguila
authors.affiliation: Nuclear Medicine Department, CHU Jean Minjoz, Besançon, France.
authors.forename: Hatem
authors.initials: H
authors.lastname: Boulahdour
mesh_terms: D000368:Aged; D055426:Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography; D005240:Feasibility Studies; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009038:Motion; D055414:Myocardial Perfusion Imaging; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D010865:Pilot Projects; D012119:Respiration; D012189:Retrospective Studies; D012984:Software; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; C078700:technetium tc-99m tetrofosmin
keywords: CZT; gated SPECT; myocardial perfusion imaging; respiratory gating; respiratory motion