title: Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro.
abstract: Pancreatic cancer is one of the most appalling cancers with a pessimistic prognosis. Despite many therapies, there has been no improvement of survival rates. In this study, we assessed the anti-cancer effects of kaempferol, a well known flavonoid having functional bio-activity against various malignant tumors. Kaempferol had anti-cancer effects on Miapaca-2, Panc-1, and SNU-213 human pancreatic cancer cells. In a dose-dependent manner, kaempferol decreased viability of these pancreatic cancer cells by increasing apoptosis. In particular, kaempferol effectively inhibited the migratory activity of human pancreatic cancer cells at relatively low dosages without any toxicity. The anti-cancer effect of kaempferol was mediated by inhibition of EGFR related Src, ERK1/2, and AKT pathways. These results collectively indicate that kaempferol, a phytochemical ingredient reported to have anti-viability and anti-oxidant properties, can act as a safety anti-migration reagent in human pancreatic cancer cells, which provide the rationale for further investigation of kaempferol as a strong candidate for the potential clinical trial of malignant pancreatic cancers.
authors.affiliation: Faculty of Biotechnology, College of Applied Life Science, SARI, Jeju National University, Jeju, Republic of Korea.
authors.forename: Jungwhoi
authors.initials: J
authors.lastname: Lee
authors.affiliation: Faculty of Biotechnology, College of Applied Life Science, SARI, Jeju National University, Jeju, Republic of Korea.|Subtropical Horticulture Research Institute, Jeju National University, Jeju, Republic of Korea.|Subtropical/tropical organism gene bank, Jeju National University, Jeju, Republic of Korea.
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D044949:Kaempferols / Q000737:chemistry / Q000494:pharmacology*; D008954:Models, Biological; D010190:Pancreatic Neoplasms; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044949:Kaempferols; D066246:ErbB Receptors