title: Relationship between paternal somatic health and assisted reproductive technology outcomes.
abstract: To study the association between paternal medical comorbidities and the outcomes of assisted reproductive technology (ART).
  
  
  
  Retrospective cohort study.
  
  
  
  Academic reproductive medicine center.
  
  
  
  We analyzed fresh ART cycles uszing freshly ejaculated sperm from the male partner of couples undergoing ART cycles from 2004 until 2014. We recorded patient and partner demographic characteristics. The cohort was linked to hospital billing data to obtain information on selected male partners' comorbidities identified using ICD-9-CM codes.
  
  
  
  None.
  
  
  
  Fertilization, clinical pregnancy, miscarriage, implantation, and live-birth rates as well as birth weights and gestational ages.
  
  
  
  In all, we identified 2,690 men who underwent 5,037 fresh ART cycles. Twenty-seven percent of men had at least one medical diagnosis. Men with nervous system diseases had on average lower pregnancy rates (23% vs. 30%) and live-birth rates (15% vs. 23%) than men without nervous system diseases. Lower fertilization rates were also observed among men with respiratory diseases (61% vs. 64%) and musculoskeletal diseases (61% vs. 64%) relative to those without these diseases. In addition, men with diseases of the endocrine system had smaller children (2,970 vs. 3,210 g) than men without such diseases. Finally, men with mental disorders had children born at an earlier gestational age (36.5 vs. 38.0 weeks).
  
  
  
  The current report identified a possible relationship between a man's health history and IVF outcomes. As these are potentially modifiable factors, further research should determine whether treatment for men's health conditions may improve or impair IVF outcomes.
authors.affiliation: Department of Urology, Stanford University, Stanford, California; Department of Obstetrics and Gynecology, Stanford University, Stanford, California. Electronic address: eisenberg@stanford.edu.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Eisenberg
authors.affiliation: Department of Urology, Stanford University, Stanford, California.
authors.forename: Shufeng
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Wise
authors.affiliation: Department of Obstetrics and Gynecology and Pediatrics, The Ohio State University, Columbus, Ohio.
authors.forename: Courtney D
authors.initials: CD
authors.lastname: Lynch
authors.affiliation: Department of Obstetrics and Gynecology, Stanford University, Stanford, California.
authors.forename: Steven
authors.initials: S
authors.lastname: Nakajima
authors.affiliation: Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, Davis, California.
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Meyers
authors.affiliation: Department of Obstetrics and Gynecology, Stanford University, Stanford, California.
authors.forename: Barry
authors.initials: B
authors.lastname: Behr
authors.affiliation: Department of Obstetrics and Gynecology, Stanford University, Stanford, California.
authors.forename: Valerie L
authors.initials: VL
authors.lastname: Baker
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000046:Academic Medical Centers; D000328:Adult; D015897:Comorbidity; D010064:Embryo Implantation; D005220:Fathers; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro / Q000009:adverse effects; D006304:Health Status; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult
keywords: Male infertility; comorbidity; fertilization in vitro; health