title: What role for radiobiphosphonates bone scintigraphy in the monitoring of an unusual bone giant cell tumor: a case report and literature review.
abstract: We report the case of 24 years old female patient, followed since ten years ago for bone giant cell tumor (GCT) of the right knee, which was complicated by pulmonary metastases. Surgical treatment and pulmonary metastasectomies have not allowed definitive cure of this disease with the appearance of metachronous bone lesions after eight years of evolution. The literature review confirms the originality of this observation: the age of the patient, the initial and metastasis locations and the occurrence of lung metastases with unfavorable prognosis. Through this clinical case, the authors highlight the role of radiobiphosphonates bone scintigraphy in detecting synchronous or metachronous bone lesions, and in monitoring of these locations under medical treatment.
authors.affiliation: Department of Nuclear Medicine, IBN-SINA Hospital Center, University Med V-Rabat Morocco.
authors.forename: Salah Nabih
authors.initials: SN
authors.lastname: Oueriagli
authors.affiliation: Department of Nuclear Medicine, IBN-SINA Hospital Center, University Med V-Rabat Morocco.
authors.forename: Imad
authors.initials: I
authors.lastname: Ghfir
authors.affiliation: Department of Nuclear Medicine, IBN-SINA Hospital Center, University Med V-Rabat Morocco.
authors.forename: Hassna El
authors.initials: HE
authors.lastname: Guerrouj
authors.affiliation: Department of Nuclear Medicine, IBN-SINA Hospital Center, University Med V-Rabat Morocco.
authors.forename: Nouzha Ben
authors.initials: NB
authors.lastname: Raïs
keywords: Bone giant cell tumor (GCT); denosumab; lung metastases; metachronous bone lesions; radiobiphosphonates bone scintigraphy