title: Surfactant-assisted water exposed electrospinning of novel super hydrophilic polycaprolactone based fibers.
abstract: Hybrid scaffolds prepared by blend electrospinning of Polycaprolactone and Pluronic solution benefit from enhanced fiber hydrophilicity and may offer satisfactory cell attachment and proliferation. To improve hybrid scaffold wettability and water swelling ratio, adequate amount of hydrophilic polymer is required; though this amount is limited by fiber surface enrichment of Pluronic and cannot be exceeded without affecting the scaffold mechanical properties. To overcome this problem, a routine blend electrospinning setup was modified by exposing the blend solution to water in order to attract Pluronic chains toward the surface of the charged jet. Morphology of scaffolds produced by the routine blend electrospinning and modified method was studied. A 50 nm thick Pluronic layer with linty appearance on the surface of the fibers fabricated by the modified method was detected. Drug-loaded fibers from modified method showed a moderate initial burst and then a prolonged release period while an abnormal two-stage phased release profile was observed for the routine blend method. The latter was associated to Pluronic/drug accumulations within the fibers fabricated by the routine method which resulted in fiber disintegration and a subsequent second burst release.
authors.affiliation: a Department of Polymer Engineering and Color Technology , Amirkabir University of Technology , Tehran , Iran.
authors.forename: S Sh
authors.initials: SS
authors.lastname: Zargarian
authors.affiliation: a Department of Polymer Engineering and Color Technology , Amirkabir University of Technology , Tehran , Iran.
authors.forename: V
authors.initials: V
authors.lastname: Haddadi-Asl
mesh_terms: D004155:Diphenhydramine / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004560:Electricity; D057927:Hydrophobic and Hydrophilic Interactions; D011060:Poloxalene / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry*; D055672:Static Electricity; D013501:Surface-Active Agents / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D011091:Polyesters; D013501:Surface-Active Agents; D014867:Water; C016240:polycaprolactone; C464484:pluronic block copolymer P123; D004155:Diphenhydramine; D011060:Poloxalene
keywords: Blend electrospinning; hydrophilicity; pluronic; surface enrichment; water exposure