title: The ANK3 gene and facial affect processing: An ERP study.
abstract: ANK3 is one of the most promising candidate genes for bipolar disorder (BD). A polymorphism (rs10994336) within the ANK3 gene has been associated with BD in at least three genome-wide association studies of BD [McGuffin et al., 2003; Kieseppä, 2004; Edvardsen et al., 2008]. Because facial affect processing is disrupted in patients with BD, the current study aimed to explore whether the BD risk alleles are associated with the N170, an early event-related potential (ERP) component related to facial affect processing. We collected data from two independent samples of healthy individuals (Ns = 83 and 82, respectively) to test the association between rs10994336 and an early event-related potential (ERP) component (N170) that is sensitive to facial affect processing. Repeated-measures analysis of covariance in both samples consistently revealed significant main effects of rs10994336 genotype (Sample I: F (1, 72) = 7.24, P = 0.009; Sample II: F (1, 69) = 11.81, P = 0.001), but no significant interaction of genotype × electrodes (Ps > 0.05) or genotype × emotional conditions (Ps > 0.05). These results suggested that rs10994336 was linked to early ERP component reflecting facial structural encoding during facial affect processing. These results shed new light on the brain mechanism of this risk SNP and associated disorders such as BD. © 2016 Wiley Periodicals, Inc.
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P.R. China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, P.R. China.
authors.forename: Wan
authors.initials: W
authors.lastname: Zhao
authors.affiliation: School of Mental Health, Jining Medical University, Jining, Shandong Province, P.R. China.
authors.forename: Qiumei
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P.R. China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, P.R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P.R. China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, P.R. China.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P.R. China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, P.R. China.
authors.forename: Xiongying
authors.initials: X
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P.R. China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, P.R. China.
authors.forename: Huang
authors.initials: H
authors.lastname: Gu
authors.affiliation: School of Mental Health, Jining Medical University, Jining, Shandong Province, P.R. China.
authors.forename: Jinguo
authors.initials: J
authors.lastname: Zhai
authors.affiliation: School of Mental Health, Jining Medical University, Jining, Shandong Province, P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P.R. China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, P.R. China.
authors.forename: Boqi
authors.initials: B
authors.lastname: Du
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P.R. China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, P.R. China.
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Deng
authors.affiliation: School of Mental Health, Jining Medical University, Jining, Shandong Province, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Ji
authors.affiliation: Beijing Anding Hospital, Beijing, P.R. China.
authors.forename: Chuanyue
authors.initials: C
authors.lastname: Wang
authors.affiliation: Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, P.R. China.
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: Xiang
authors.affiliation: Center for Cognitive Neuroscience, Duke University, Durham, North Carolina.
authors.forename: Dawei
authors.initials: D
authors.lastname: Li
authors.affiliation: Shengli Hospital of Shengli Petroleum Administration Bureau, Dongying, Shandong Province, P.R. China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P.R. China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, P.R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Dong
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P.R. China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, P.R. China.
authors.forename: Yuejia
authors.initials: Y
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, P.R. China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Psychology and Social Behavior, University of California, Irvine, California.
authors.forename: Chuansheng
authors.initials: C
authors.lastname: Chen
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology; D017487:Ankyrins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D001714:Bipolar Disorder / Q000235:genetics / Q000378:metabolism; D001921:Brain; D016022:Case-Control Studies; D002681:China; D004569:Electroencephalography / Q000379:methods; D005006:Ethnicity / Q000235:genetics; D005071:Evoked Potentials / Q000235:genetics; D005145:Face; D000066499:Facial Recognition; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C490613:ANK3 protein, human; D017487:Ankyrins
keywords: ANK3; N170; event-related potential; facial affect processing; polymorphism