title: Data on the lipoprotein (a), coronary atherosclerotic burden and vulnerable plaque phenotype in angiographic obstructive coronary artery disease.
abstract: Lipoprotein Lp(a) represents an independent risk factor for coronary artery disease (CAD). However, its association with CAD burden and lipid rich plaques prone to rupture in patients with acute coronary syndrome (ACS) still remains unknown. These data aim to investigate the association among serum Lipoprotein(a) (Lpa) levels, coronary atherosclerotic burden and features of culprit plaque in patients with ACS and obstructive CAD. For his reason, a total of 500 ACS patients were enrolled for the angiographic cohort and 51 ACS patients were enrolled for the optical coherence tomography (OCT) cohort. Angiographic CAD severity was assessed by Sullivan score and by Bogaty score including stenosis score and extent index, whereas OCT plaque features were evaluated at the site of the minimal lumen area and along the culprit segment. In the angiographic cohort, Lp(a) was a weak independent predictor of Sullivan score (p<0.0001), stenosis score (p<0.0001) and extent index (p<0.0001). In the OCT cohort, patients with higher Lp(a) levels (>30 md/dl) compared to patients with lower Lp(a) levels (<30 md/dl) exhibited a higher prevalence of lipidic plaque at the site of the culprit stenosis (P=0.02), a wider lipid arc (p=0.003) and a higher prevalence of thin-cap fibroatheroma (p=0.004).
authors.affiliation: Cardiology Department, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Niccoli
authors.affiliation: Cardiology Department, Department of Clinical and Molecular Medicine, 2nd School of Medicine, University of Rome "Sapienza", S. Andrea Hospital, Rome, Italy.
authors.forename: Diana
authors.initials: D
authors.lastname: Chin
authors.affiliation: Cardiology Department, Catholic University of the Sacred Heart, Rome, Italy; Thorax Institute, Hospital Clinic, University of Barcelona, Spain.
authors.forename: Giancarla
authors.initials: G
authors.lastname: Scalone
authors.affiliation: Cardiology Department, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Panebianco
authors.affiliation: Cardiology Department, Department of Clinical and Molecular Medicine, 2nd School of Medicine, University of Rome "Sapienza", S. Andrea Hospital, Rome, Italy.
authors.forename: Sofia
authors.initials: S
authors.lastname: Abbolito
authors.affiliation: Cardiology Department, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Cosentino
authors.affiliation: Cardiology Department, Department of Clinical and Molecular Medicine, 2nd School of Medicine, University of Rome "Sapienza", S. Andrea Hospital, Rome, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Jacoangeli
authors.affiliation: Cardiology Department, Catholic University of the Sacred Heart, Rome, Italy; Cardiology Department, Zagazig University, Zagazig, Egypt.
authors.forename: Hesham
authors.initials: H
authors.lastname: Refaat
authors.affiliation: Cardiology Department, Department of Clinical and Molecular Medicine, 2nd School of Medicine, University of Rome "Sapienza", S. Andrea Hospital, Rome, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Gallo
authors.affiliation: Cardiology Department, Department of Clinical and Molecular Medicine, 2nd School of Medicine, University of Rome "Sapienza", S. Andrea Hospital, Rome, Italy.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Salerno
authors.affiliation: Cardiology Department, Department of Clinical and Molecular Medicine, 2nd School of Medicine, University of Rome "Sapienza", S. Andrea Hospital, Rome, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Volpe
authors.affiliation: Cardiology Department, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Crea
authors.affiliation: Cardiology Department, Department of Clinical and Molecular Medicine, 2nd School of Medicine, University of Rome "Sapienza", S. Andrea Hospital, Rome, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: De Biase
keywords: Acute coronary syndrome; Angiographic analysis; Lipoprotein (a); Optical coherence tomography