title: Comparison of Dexmedetomidine-Ketamine with Isoflurane for Anesthesia of Chinchillas (Chinchilla lanigera).
abstract: The objective of this study was to compare isoflurane with a combination of dexmedetomidine and ketamine, administered intramuscularly, for anesthesia in chinchillas (Chinchilla lanigera). In a prospective, complete crossover study, adult chinchillas (n = 8; age, 2 to 5 y) were anesthetized with a combination of dexmedetomidine (0.015 mg/kg IM) and ketamine (4 mg/kg IM). Atipamezole (0.15 mg/kg) was injected subcutaneously 45 min after dexmedetomidine-ketamine administration. For comparison, anesthesia also was induced and maintained with isoflurane in 100% oxygen, delivered by facemask. Anesthetic and physiologic parameters were recorded during each anesthesia, including various reflexes, heart rate, respiratory rate, body temperature, and SpO2. Food intake, fecal output, and body weight were recorded daily for 6 d after each anesthetic trial. Induction time, heart rate, respiratory rate, and body temperature did not differ significantly between the 2 anesthetic protocols. Recovery times were shorter and SpO2 was higher in animals that received isoflurane delivered in 100% oxygen. Food intake and fecal output were reduced in the dexmedetomidine-ketamine group for as long as 3 d after anesthesia, whereas isoflurane had no signifcant effect on food intake or fecal output. Both anesthetic protocols provided effective anesthesia in chinchillas. However, when anesthetized with dexmedetomidine-ketamine, chinchillas received room air and became hypoxemic. Future studies are needed to evaluate the effect of oxygen supplementation on anesthetic recovery and on the recovery of food intake and fecal output in chinchillas.
authors.affiliation: Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors.forename: Lana
authors.initials: L
authors.lastname: Fox
authors.affiliation: Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors.forename: Lindsey Bc
authors.initials: LB
authors.lastname: Snyder
authors.affiliation: Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA. christoph.mans@wisc.edu.
authors.forename: Christoph
authors.initials: C
authors.lastname: Mans
mesh_terms: D000758:Anesthesia / Q000009:adverse effects / Q000662:veterinary*; D000762:Anesthesia Recovery Period; D000818:Animals; D001835:Body Weight; D002682:Chinchilla; D018592:Cross-Over Studies; D020927:Dexmedetomidine / Q000008:administration & dosage* / Q000009:adverse effects; D004435:Eating; D005260:Female; D007530:Isoflurane / Q000008:administration & dosage*; D007649:Ketamine / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D011446:Prospective Studies
chemical_list: D020927:Dexmedetomidine; D007649:Ketamine; D007530:Isoflurane