title: Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants.
abstract: On-demand, localized release of drugs in precisely controlled, patient-specific time sequences represents an ideal scenario for pharmacological treatment of various forms of hormone imbalances, malignant cancers, osteoporosis, diabetic conditions and others. We present a wirelessly operated, implantable drug delivery system that offers such capabilities in a form that undergoes complete bioresorption after an engineered functional period, thereby obviating the need for surgical extraction. The device architecture combines thermally actuated lipid membranes embedded with multiple types of drugs, configured in spatial arrays and co-located with individually addressable, wireless elements for Joule heating. The result provides the ability for externally triggered, precision dosage of drugs with high levels of control and negligible unwanted leakage, all without the need for surgical removal.In vitroandin vivoinvestigations reveal all of the underlying operational and materials aspects, as well as the basic efficacy and biocompatibility of these systems.
authors.affiliation: Weldon School of Biomedical Engineering and School of Mechanical Engineering and The Center for Implantable Devices and Birck Nanotechnology Center, Purdue University, West Lafayette, IN, USA; Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Chi Hwan
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Hojun
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Daniel V
authors.initials: DV
authors.lastname: Harburg
authors.affiliation: Department of Biomicrosystem Technology, Korea University, Seoul, Republic of Korea; Department of Biochemistry and Molecular Biology, Global Research Laboratory, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Gayoung
authors.initials: G
authors.lastname: Park
authors.affiliation: Department of Civil and Environmental Engineering, and Mechanical Engineering, Center for Engineering and Health and Skin Disease Resesarch Center, Northwestern University, Evanston, IL, USA; Center for Mechanics and Materials, Tsinghua University, Beijing, China.
authors.forename: Yinji
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Civil and Environmental Engineering, and Mechanical Engineering, Center for Engineering and Health and Skin Disease Resesarch Center, Northwestern University, Evanston, IL, USA; State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Sichuan, China.
authors.forename: Taisong
authors.initials: T
authors.lastname: Pan
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Jae Soon
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Na Yeon
authors.initials: NY
authors.lastname: Lee
authors.affiliation: Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Bong Hoon
authors.initials: BH
authors.lastname: Kim
authors.affiliation: Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Kyung-In
authors.initials: KI
authors.lastname: Jang
authors.affiliation: Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Seung-Kyun
authors.initials: SK
authors.lastname: Kang
authors.affiliation: Department of Civil and Environmental Engineering, and Mechanical Engineering, Center for Engineering and Health and Skin Disease Resesarch Center, Northwestern University, Evanston, IL, USA.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Biochemistry and Molecular Biology, Global Research Laboratory, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jeongmin
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Biochemistry and Molecular Biology, Global Research Laboratory, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Kyung-Mi
authors.initials: KM
authors.lastname: Lee
authors.affiliation: Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Leal
authors.affiliation: Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Rogers