title: [ANEMIC SYNDROME IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA].
abstract: Community-acquired pneumonia remains a most widespread acute infectious disease of socio-economic significance all over the world. Up to 30% of the patients present with anemia responsible for the unfavourable prognosis and elevated mortality. Not infrequently, anemia is not diagnosed during the hospital stay und therefore remains uncorrected. Severe anemia results in enhanced hypercapnia and slowed maturation of red blood cells in the bone marrow which facilitates the development of ischemic syndrome. Hepcidin, a mediator of inflammation and iron-regulatory hormone, plays an important role in the clinical course of community-acquired pneumonia. Hepsidin production increases during inflammation; it suppresses erythtropoiesis and depletes the iron depot leading to so-called anemia of inflammation. Hypoxia and anemia activate erythtropoiesis, and the released erythropoietin inhibits hepsidin production. During pneumonia resolution, hepsidin promotes recovery from anemia by activating iron absorption. The curreni literature contains few data on the use of hepcidin as a diagnostic marker of anemia. The necessity oftreating anemia in patients with pneumonia under hospital conditions is a matter of discussion. Direct involvement of hepcidin in iron metabolism creates a prerequisite for the treatment of anemia. Medicamental suppression of its activity by stimulating erythtropoiesis can facilitate normalization of iron metabolism and restoration of hemoglobin level.
authors.forename: A V
authors.initials: AV
authors.lastname: Budnevsky
authors.forename: I E
authors.initials: IE
authors.lastname: Esaulenko
authors.forename: E S
authors.initials: ES
authors.lastname: Ovsyannikov
authors.forename: N B
authors.initials: NB
authors.lastname: Labzhaniya
authors.forename: E V
authors.initials: EV
authors.lastname: Voronina
authors.forename: A V
authors.initials: AV
authors.lastname: Chernov
mesh_terms: D000740:Anemia / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D015415:Biomarkers / Q000378:metabolism; D017714:Community-Acquired Infections / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D006397:Hematinics / Q000627:therapeutic use*; D064451:Hepcidins / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D011014:Pneumonia / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D006397:Hematinics; D064451:Hepcidins; D007501:Iron