title: Renal Cell Carcinoma in a Young Adult - Do We Need Further Investigations?
abstract: Renal cell carcinomas (RCC), mostly occurring in adults aged 60-70 years, can result from well-known factors like cigarette smoking, obesity and hypertension. However, they have been associated with genetic alterations in children and young adults. A 28 year-old male patient with a confirmed RCC underwent biomolecular and immunohistochemical analyses due to his young age. A point mutation of the von Hippel-Lindau tumor suppressor gene was identified. Young patients under 40 years with diagnosed RCC should undergo additional diagnostic investigation, hence the discovery of an underlying cause. This could be important for further treatment and counseling of these young patients.
authors.affiliation: Department of Urology, Cantonal Hospital Aarau, Aarau, Switzerland; SCI Center and Research, Neuro-Urology, Balgrist University Hospital, Zurich, Switzerland; Department of Urology, University Hospital Basel, Basel, Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Walter
authors.affiliation: Department of Urology, University Hospital Basel, Basel, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Wetterauer
authors.affiliation: Institute of Pathology, University Hospital Basel, Basel, Switzerland.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Bruder
authors.affiliation: Institute of Pathology, University Hospital Basel, Basel, Switzerland.
authors.forename: Ellen C
authors.initials: EC
authors.lastname: Obermann
authors.affiliation: Department of Urology, Cantonal Hospital Baselland, Liestal, Switzerland.
authors.forename: Svetozar
authors.initials: S
authors.lastname: Subotic
authors.affiliation: Department of Urology, Cantonal Hospital Aarau, Aarau, Switzerland.
authors.forename: Stephen
authors.initials: S
authors.lastname: Wyler
keywords: Biomolecular and immunohistochemistry analysis; Renal cell carcinoma; Young adults; von Hippel-Lindau