title: Metamizole Sodium Induces Neural Tube Defects in a Chick Embryo Model.
abstract: OBJECTIVE
  The aim of this study was to investigate the effects of metamizole sodium on neural tube development in the early stage chick embryo model that complies with the first month of embryonic development in mammals.
  
  
  METHODS
  A total of 40 fertilized chicken eggs were divided into 4 equal groups. The eggs were incubated in the incubator at a temperature of 37.8±2°C with 60±5% humidity. Group A was the control, Group B was administered physiological saline, Group C was administered 30 mg/kg metamizole sodium (based on the therapeutic index range of it used in humans) and Group D was administered 90 mg/kg metamizole sodium. All embryos were removed from the egg at the 48th hour and morphologically and histologically examined.
  
  
  RESULTS
  Normal development was seen and the neural tube was closed in 17 embryos in Groups A and B. A neural tube defect was seen in 2 embryos in group A and in 1 embryo in group B. A neural tube closure defect was seen in all embryos in group C and 9 embryos in group D. There was 1 dead embryo in Group D.
  
  
  CONCLUSIONS
  Metamizole sodium was seen to produce a neural tube defect in the chicken embyro model.
authors.affiliation: Dr. N. K. Sincan State Hospital, Department of Neurosurgery, Ankara, Turkey.
authors.forename: Yahya
authors.initials: Y
authors.lastname: Guvenc
authors.forename: Deniz
authors.initials: D
authors.lastname: Billur
authors.forename: Sevim
authors.initials: S
authors.lastname: Aydin
authors.forename: Ersin
authors.initials: E
authors.lastname: Ozeren
authors.forename: Adnan
authors.initials: A
authors.lastname: Demirci
authors.forename: Fatih
authors.initials: F
authors.lastname: Alagoz
authors.forename: Ali
authors.initials: A
authors.lastname: Dalgic
authors.forename: Deniz
authors.initials: D
authors.lastname: Belen
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D002642:Chick Embryo; D004177:Dipyrone / Q000633:toxicity*; D047108:Embryonic Development / Q000187:drug effects; D054259:Neural Tube / Q000196:embryology; D009436:Neural Tube Defects / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004177:Dipyrone