title: PET in the Assessment of Pediatric Brain Development and Developmental Disorders.
abstract: This article discusses and reviews the role and contribution of PET in understanding the structural and functional changes that occur during brain development, and how these changes relate to behavioral and cognitive development in the infant and child. Data regarding various aspects of brain development, such as glucose metabolism, protein synthesis, and maturation and development of neurotransmitter systems will help in understanding the pathogenesis and neurologic basis of various developmental and neurologic disorders. This may help in following disease evolution and progression, planning and development of various therapeutic interventions, timing these interventions and monitoring their responses, and rendering long-term prognostication.
authors.affiliation: Departments of Pediatrics and Neurology, School of Medicine, Wayne State University, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201, USA.
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Departments of Pediatrics and Neurology, School of Medicine, Wayne State University, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI 48201, USA; Division of Pediatric Neurology, Children's Hospital of Michigan, 3901 Beaubien Boulevard, Detroit, MI, USA; PET Center, Children's Hospital of Michigan, Detroit, MI 48201, USA. Electronic address: hchugani@pet.wayne.edu.
authors.forename: Harry T
authors.initials: HT
authors.lastname: Chugani
keywords: Alpha methyl tryptophan (AMT); Brain development; Developmental disorder; FDG; Flumazenil (FMZ); Functional imaging; Pediatric; Positron emission tomography (PET)