title: The Innate Lymphoid Cell Precursor.
abstract: The discovery of tissue-resident innate lymphoid cell populations effecting different forms of type 1, 2, and 3 immunity; tissue repair; and immune regulation has transformed our understanding of mucosal immunity and allergy. The emerging complexity of these populations along with compounding issues of redundancy and plasticity raise intriguing questions about their precise lineage relationship. Here we review advances in mapping the emergence of these lineages from early lymphoid precursors. We discuss the identification of a common innate lymphoid cell precursor characterized by transient expression of the transcription factor PLZF, and the lineage relationships of innate lymphoid cells with conventional natural killer cells and lymphoid tissue inducer cells. We also review the rapidly growing understanding of the network of transcription factors that direct the development of these lineages.
authors.affiliation: Committee on Immunology, The University of Chicago, Illinois 60637; email: abendela@bsd.uchicago.edu.|Department of Pathology, The University of Chicago, Illinois 60637.
authors.forename: Isabel E
authors.initials: IE
authors.lastname: Ishizuka
authors.affiliation: Committee on Immunology, The University of Chicago, Illinois 60637; email: abendela@bsd.uchicago.edu.|Department of Pathology, The University of Chicago, Illinois 60637.|Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Constantinides
authors.affiliation: Committee on Immunology, The University of Chicago, Illinois 60637; email: abendela@bsd.uchicago.edu.|Institute of Biophysical Dynamics, The University of Chicago, Illinois 60637.|Department of Chemistry, The University of Chicago, Illinois 60637.
authors.forename: Herman
authors.initials: H
authors.lastname: Gudjonson
authors.affiliation: Committee on Immunology, The University of Chicago, Illinois 60637; email: abendela@bsd.uchicago.edu.|Department of Pathology, The University of Chicago, Illinois 60637.
authors.forename: Albert
authors.initials: A
authors.lastname: Bendelac
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D016207:Cytokines / Q000378:metabolism; D005786:Gene Expression Regulation / Q000276:immunology; D053263:Gene Regulatory Networks; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007113:Immunity, Innate; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology*; D054503:Lymphoid Progenitor Cells / Q000276:immunology*; D000075722:Promyelocytic Leukemia Zinc Finger Protein; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D016207:Cytokines; D051741:Kruppel-Like Transcription Factors; D000075722:Promyelocytic Leukemia Zinc Finger Protein; C092037:ZBTB16 protein, human
keywords: innate lymphoid cell development; innate lymphoid cell precursor; promyelocytic leukemia zinc factor; transcription factors