title: The Ubiquitination of NF-κB Subunits in the Control of Transcription.
abstract: Nuclear factor (NF)-κB has evolved as a latent, inducible family of transcription factors fundamental in the control of the inflammatory response. The transcription of hundreds of genes involved in inflammation and immune homeostasis require NF-κB, necessitating the need for its strict control. The inducible ubiquitination and proteasomal degradation of the cytoplasmic inhibitor of κB (IκB) proteins promotes the nuclear translocation and transcriptional activity of NF-κB. More recently, an additional role for ubiquitination in the regulation of NF-κB activity has been identified. In this case, the ubiquitination and degradation of the NF-κB subunits themselves plays a critical role in the termination of NF-κB activity and the associated transcriptional response. While there is still much to discover, a number of NF-κB ubiquitin ligases and deubiquitinases have now been identified which coordinate to regulate the NF-κB transcriptional response. This review will focus the regulation of NF-κB subunits by ubiquitination, the key regulatory components and their impact on NF-κB directed transcription.
authors.affiliation: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. patricia.collins@glasgow.ac.uk.
authors.forename: Patricia E
authors.initials: PE
authors.lastname: Collins
authors.affiliation: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. i.mitxitorena.1@research.gla.ac.uk.
authors.forename: Izaskun
authors.initials: I
authors.lastname: Mitxitorena
authors.affiliation: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. ruaidhri.carmody@glasgow.ac.uk.
authors.forename: Ruaidhrí J
authors.initials: RJ
authors.lastname: Carmody
keywords: NF-κB; transcription; ubiquitination