title: Clinicopathological characteristics of patients of certain molecular subtypes and elevated postoperative cancer antigen 15.3 levels and its correlation with menopausal status.
abstract: BACKGROUND
  It is well established that breast cancer subtypes differ in their outcome and treatment response.
  
  
  OBJECTIVE
  To observe tumor characteristics of different molecular subgroup and patients with postoperative (PO) raised cancer antigen 15.3 (CA 15.3) group and variation of tumor nature between pre- and post-menopausal breast cancer patients.
  
  
  METHODS
  Blood samples and tumor blocks were collected from 95 nonmetastatic female breast cancer patients. Immunohistochemical stains for estrogen receptors (ER), progesterone receptor (PR), and HER2/Neu were used to classify molecular subtypes. CA 15.3 level was detected by ELISA. Significance levels were ascertained by Pearson Chi-square test.
  
  
  RESULTS
  Prevalence of luminal A tumor with grade 3 was high. Triple negative and ER positive (ER+) types showed tumors with high grade and high lymph node (LN) metastasis. More nodal involvement was noticed in patients with PO raised CA 15.3. In addition, premenopausal patients with triple-negative and ER+ subtypes exhibited more aggressive tumors which were characterized by high grade and large numbers of LN metastasis.
  
  
  CONCLUSIONS
  Clinicopathological characteristics of certain molecular subtypes and influence of menopausal status on it can predict disease recurrence or overall survival of breast cancer patients.
authors.affiliation: Department of General Surgery, IPGME and R/SSKMH, Kolkata, West Bengal, India.
authors.forename: Soumi
authors.initials: S
authors.lastname: Saha
authors.affiliation: Department of General Surgery, IPGME and R/SSKMH, Kolkata, West Bengal, India.
authors.forename: Suvro
authors.initials: S
authors.lastname: Ganguly
authors.affiliation: Department of General Surgery, IPGME and R/SSKMH, Kolkata, West Bengal, India.
authors.forename: Diptendra Kumar
authors.initials: DK
authors.lastname: Sarkar
authors.affiliation: Department of Pharmacology, IPGME and R/SSKMH, Kolkata, West Bengal, India.
authors.forename: Avijit
authors.initials: A
authors.lastname: Hazra
mesh_terms: D000328:Adult; D000368:Aged; D000941:Antigens; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008593:Menopause; D008853:Microscopy; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood* / Q000235:genetics*; D012008:Recurrence; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D000941:Antigens; D018396:Mucin-1