title: Development of CNS-type Primitive Neuroectodermal Tumor in Metastatic Testicular Mixed Germ Cell Tumor.
abstract: A 29-year-old man presenting with a retroperitoneal mass was found to have a testis lesion consistent with mixed germ cell tumor and the RPLND specimen showed teratoma with an area of central nervous system-type primitive neuroectodermal tumor (PNET) not present in the testis. Whether such primitive tumor components represent a de novo tumor component or represent progression from existing neuroepithelial teratomatous elements is unclear. Given the high likelihood of residual tumor and possibility of malignant transformation, post-chemotherapy RPLND remains vital in treating patients with testis cancer. PNET is chemo-resistant and lesions should be resected, without clear evidence for adjuvant chemotherapy.
authors.affiliation: Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, USA; Department of Urology, University of Washington, USA.
authors.forename: Anobel Y
authors.initials: AY
authors.lastname: Odisho
authors.affiliation: Department of Pathology, University of California, San Francisco, USA.
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Rabban
authors.affiliation: Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, USA.
authors.forename: Maxwell V
authors.initials: MV
authors.lastname: Meng
keywords: Germ cell tumor; Retroperitoneal lymph node dissection; Teratoma; Testicular cancer