title: [The prognostic value of selected immunological factors in ovarian cancer patients].
abstract: Ovarian cancer is the most aggressive gynecological cancer and is often diagnosed in advanced stage. Constantly we are looking for new prognostic factors which would enable early diagnosis, increase the effectiveness of therapeutic intervention. There is to little data about immunological predictors in ovarian cancer. The tumor's microenvironment is designated by regulatory T cells, cytotoxic T cells, dendritic cells (DCs), tumor - associated macrophages (TAMs), monocytes, plasma cells and cytokines, such as IL-6, IL-8, IL-10, IL-17 and TGF-beta. Some of them are responsible for the inhibition and others induce tumor growth. Ovarian cancer patients with high ratio of CD8 + TILs to Treg present longer overall survival time (OS). The presence of T helper cells in ascites is associated with longer OS. Furthermore, patients with a lower rate plasmocytoid DCs infiltrating tumor tissue demonstrate longer progression-free survival time (PFS). Women with increased M1/M2 ratio present higher five-year survival rate. The presence of immunologically competent cells and secreted cytokines give motivation to evaluate their prognostic value. Perhaps this strategy will contribute to longer progression-free survival time and overall survival time in those patients.
authors.affiliation: I Katedra i Klinika Ginekologii Onkologicznej i Ginekologii, Uniwersytet Medyczny, Lublin.
authors.forename: Monika
authors.initials: M
authors.lastname: Bilska
authors.affiliation: I Katedra i Klinika Ginekologii Onkologicznej i Ginekologii, Uniwersytet Medyczny, Lublin.
authors.forename: Iwona
authors.initials: I
authors.lastname: Wertel
authors.affiliation: I Katedra i Klinika Ginekologii Onkologicznej i Ginekologii, Uniwersytet Medyczny, Lublin.
authors.forename: Justyna
authors.initials: J
authors.lastname: Surówka
authors.affiliation: I Katedra i Klinika Ginekologii Onkologicznej i Ginekologii, Uniwersytet Medyczny, Lublin.
authors.forename: Karolina
authors.initials: K
authors.lastname: Okła
authors.affiliation: Katedra i Zakład Immunologii Klinicznej, Uniwersytet Medyczny, Lublin.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Bilski
authors.affiliation: I Katedra i Klinika Ginekologii Onkologicznej i Ginekologii, Uniwersytet Medyczny, Lublin.
authors.forename: Rafał
authors.initials: R
authors.lastname: Tarkowski
authors.affiliation: I Katedra i Klinika Ginekologii Onkologicznej i Ginekologii, Uniwersytet Medyczny, Lublin.
authors.forename: Jan
authors.initials: J
authors.lastname: Kotarski
mesh_terms: D014408:Biomarkers, Tumor / Q000276:immunology* / Q000378:metabolism*; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism*; D011379:Prognosis; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D016207:Cytokines; D016212:Transforming Growth Factor beta