title: CD1A, D and E gene polymorphisms in a North African population from Morocco.
abstract: CD1 molecules are specialized in capturing and presenting lipids and glycolipids to distinct subsets of T and NKT cells. Glycolipid presentation could play a significant role in the immune response against microbial infections. There are five closely linked CD1 genes in humans, named CD1A, B, C, D, and E, which all show a limited polymorphism. In this study, exon 2 polymorphisms of CD1A, CD1D and CD1E were investigated and allele, genotype and haplotype frequencies of these loci were reported in a Moroccan population. A comparison with allele, genotype and haplotype frequencies observed in other geographic areas was also performed. Results confirmed the presence of ethnic differences in CD1 polymorphism, mainly in CD1D (in this population two additional CD1D variant alleles, CD1D(∗)03 and CD1D(∗)04, were described) and E genes. These data could be useful to evaluate a possible pathogenetic role of CD1 in diseases. Increasing the knowledge in this field may offer possibilities for the development of new immunotherapeutic approaches.
authors.affiliation: CNR Institute of Translational Pharmacology, UOS L'Aquila, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Aureli
authors.affiliation: Laboratoire d'Immunologie, Institut National D'Hygiene, Rabat, Morocco.
authors.forename: Khadija
authors.initials: K
authors.lastname: Oumhani
authors.affiliation: CNR Institute of Translational Pharmacology, UOS L'Aquila, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Del Beato
authors.affiliation: Hassan II Academy of Science and Technology, Rabat, Morocco.
authors.forename: Rajae
authors.initials: R
authors.lastname: El Aouad
authors.affiliation: CNR Institute of Translational Pharmacology, UOS L'Aquila, Italy. Electronic address: daniela.piancatelli@cnr.it.
authors.forename: Daniela
authors.initials: D
authors.lastname: Piancatelli
mesh_terms: D018949:Antigens, CD1 / Q000235:genetics*; D055610:Antigens, CD1d / Q000235:genetics*; D003602:Cytotoxicity, Immunologic; D004252:DNA Mutational Analysis; D005006:Ethnicity; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007109:Immunity / Q000235:genetics; D007239:Infections / Q000235:genetics* / Q000276:immunology; D009018:Morocco; D055611:Natural Killer T-Cells / Q000276:immunology*; D011110:Polymorphism, Genetic
chemical_list: D018949:Antigens, CD1; D055610:Antigens, CD1d; C526877:CD1D protein, human; C419393:CD1a antigen; C417738:CD1e antigen
keywords: CD1; Morocco; Polymorphism; Population genetics; Sequence based typing (SBT)