title: New insulin preparations: A primer for the clinician.
abstract: The importance of glycemic control in preventing the chronic and devastating complications of diabetes is well established. Insulin administration is an important therapeutic option for managing diabetes, particularly for patients with profound insulin deficiency. Many insulin formulations are on the market, including short-acting insulin analogues, inhaled insulin, concentrated insulin, and basal insulin. Each category has a unique onset, peak, and duration of action. This article reviews the differing pharmacokinetic and pharmacodynamic properties and safety and efficacy data, and discusses the implications for clinical practice.
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center and Parkland Health & Hospital System, Dallas, TX, USA. E-mail: Luigi.Meneghini@UTSouthwestern.edu.
authors.forename: Luigi
authors.initials: L
authors.lastname: Meneghini
mesh_terms: D001786:Blood Glucose / Q000187:drug effects; D003920:Diabetes Mellitus / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics*; D000069057:Insulin Detemir / Q000493:pharmacokinetics; D061266:Insulin, Short-Acting / Q000493:pharmacokinetics; D061385:Insulins / Q000493:pharmacokinetics*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D061266:Insulin, Short-Acting; D061385:Insulins; D000069057:Insulin Detemir