title: GPCRdb: the G protein-coupled receptor database - an introduction.
abstract: GPCRs make up the largest family of human membrane proteins and of drug targets. Recent advances in GPCR pharmacology and crystallography have shed new light on signal transduction, allosteric modulation and biased signalling, translating into new mechanisms and principles for drug design. The GPCR database, GPCRdb, has served the community for over 20 years and has recently been extended to include a more multidisciplinary audience. This review is intended to introduce new users to the services in GPCRdb, which meets three overall purposes: firstly, to provide reference data in an integrated, annotated and structured fashion, with a focus on sequences, structures, single-point mutations and ligand interactions. Secondly, to equip the community with a suite of web tools for swift analysis of structures, sequence similarities, receptor relationships, and ligand target profiles. Thirdly, to facilitate dissemination through interactive diagrams of, for example, receptor residue topologies, phylogenetic relationships and crystal structure statistics. Herein, these services are described for the first time; visitors and guides are provided with good practices for their utilization. Finally, we describe complementary databases cross-referenced by GPCRdb and web servers with corresponding functionality.
authors.affiliation: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Munk
authors.affiliation: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: V
authors.identifier: 0000-0002-1042-040X
authors.initials: V
authors.lastname: Isberg
authors.affiliation: Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
authors.forename: S
authors.initials: S
authors.lastname: Mordalski
authors.affiliation: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: K
authors.identifier: 0000-0002-9326-9644
authors.initials: K
authors.lastname: Harpsøe
authors.affiliation: Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Rataj
authors.affiliation: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: A S
authors.identifier: 0000-0003-1098-6419
authors.initials: AS
authors.lastname: Hauser
authors.affiliation: Department of Pharmaceutical Chemistry, Philipps-University Marburg, Marburg, Germany.
authors.forename: P
authors.identifier: 0000-0003-4089-614X
authors.initials: P
authors.lastname: Kolb
authors.affiliation: Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
authors.forename: A J
authors.initials: AJ
authors.lastname: Bojarski
authors.affiliation: Centre for Molecular and Biomolecular Informatics, Radboudumc, Nijmegen, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Vriend
authors.affiliation: Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: D E
authors.identifier: 0000-0002-4299-7561
authors.initials: DE
authors.lastname: Gloriam
mesh_terms: D030562:Databases, Protein; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D043562:Receptors, G-Protein-Coupled