title: Silent dissemination of colistin-resistant Escherichia coli in South America could contribute to the global spread of the mcr-1 gene.
abstract: During a Brazilian multicentric antimicrobial resistance surveillance study, colistin resistance was investigated in 4,620 Enterobacteriaceae isolated from human, animal, food and environmental samples collected from 2000 to 2016. We present evidence that mcr-1-positive Escherichia coli has been emerging in South America since at least 2012, supporting a previous report on the possible acquisition of mcr-1-harbouring E. coli by European travellers visiting Latin American countries.
authors.affiliation: Department of Clinical Analysis, School of Pharmacy, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Miriam R
authors.initials: MR
authors.lastname: Fernandes
authors.forename: Quezia
authors.initials: Q
authors.lastname: Moura
authors.forename: Luciana
authors.initials: L
authors.lastname: Sartori
authors.forename: Ketrin C
authors.initials: KC
authors.lastname: Silva
authors.forename: Marcos Pv
authors.initials: MP
authors.lastname: Cunha
authors.forename: Fernanda
authors.initials: F
authors.lastname: Esposito
authors.forename: Ralf
authors.initials: R
authors.lastname: Lopes
authors.forename: Luciana K
authors.initials: LK
authors.lastname: Otutumi
authors.forename: Daniela D
authors.initials: DD
authors.lastname: Gonçalves
authors.forename: Milena
authors.initials: M
authors.lastname: Dropa
authors.forename: Maria H
authors.initials: MH
authors.lastname: Matté
authors.forename: Daniel Fm
authors.initials: DF
authors.lastname: Monte
authors.forename: Mariza
authors.initials: M
authors.lastname: Landgraf
authors.forename: Gabriela R
authors.initials: GR
authors.lastname: Francisco
authors.forename: Maria Fc
authors.initials: MF
authors.lastname: Bueno
authors.forename: Doroti
authors.initials: D
authors.lastname: de Oliveira Garcia
authors.forename: Terezinha
authors.initials: T
authors.lastname: Knöbl
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Moreno
authors.forename: Nilton
authors.initials: N
authors.lastname: Lincopan
mesh_terms: D000821:Animal Feed / Q000382:microbiology; D000818:Animals; D000829:Animals, Domestic / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D058345:Asymptomatic Infections / Q000453:epidemiology; D003091:Colistin / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology* / Q000662:veterinary; D029968:Escherichia coli Proteins / Q000378:metabolism*; D005506:Food Contamination / Q000032:analysis; D005516:Food Microbiology / Q000706:statistics & numerical data; D014943:Global Health / Q000706:statistics & numerical data; D006801:Humans; D013020:South America / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; C000614037:MCR-1 protein, E coli; D003091:Colistin
keywords: Brazil; ESBL; Enterobacteriaceae; MCR-1; South America; colistin resistance