title: Polydopamine-coated liposomes as pH-sensitive anticancer drug carriers.
abstract: Stimuli-responsive drug carriers are considered to play important roles in chemotherapy. We fabricated pH-sensitive polydopamine-protected liposomes (liposome@PDA) drug delivery systems, which were characterised with microscope, scanning electron microscope (SEM), UV-vis spectrometer and Fourier transform infrared (FTIR) technieques. The typical chemotherapeutic agent, 5-fluorouracil (5-FU), was loaded into liposome@PDA capsules. The maximum release percentages of 5-FU are 3.2%, 29.5%, 52.7%, 76.7% in the solution with pH 7.42, 6.87, 4.11 and 3.16, respectively. The in vitro cell cytotoxity experiments were carried out using 5-FU-loaded capsules at pH 6.87 solution, which simulate the true pH around cancerous cells. At 1.5 μM concentration, the free 5-FU, 5-FU-loaded liposome capsules and 5-FU-loaded capsules showed the cell viability of 50.56%, 22.66% and 21.63%, respectively. It confirms that drug-loaded capsules performed better than free drug. The results demonstrate the great potential of liposome@PDA capsules as carriers in biomedical applications.
authors.affiliation: a State Key Laboratory of Urban Water Resource and Environment, School of Chemical Engineering and Technology , Harbin Institute of Technology , Harbin , China ;
authors.forename: Wei
authors.initials: W
authors.lastname: Zong
authors.affiliation: b School of Life Science and Technology , Harbin Institute of Technology , Harbin , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.affiliation: a State Key Laboratory of Urban Water Resource and Environment, School of Chemical Engineering and Technology , Harbin Institute of Technology , Harbin , China ;
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Su
authors.affiliation: b School of Life Science and Technology , Harbin Institute of Technology , Harbin , China.
authors.forename: Nan
authors.initials: N
authors.lastname: Luo
authors.affiliation: a State Key Laboratory of Urban Water Resource and Environment, School of Chemical Engineering and Technology , Harbin Institute of Technology , Harbin , China ;
authors.forename: Xunan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: a State Key Laboratory of Urban Water Resource and Environment, School of Chemical Engineering and Technology , Harbin Institute of Technology , Harbin , China ;
authors.forename: Qingchuan
authors.initials: Q
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Urban Water Resource and Environment, School of Chemical Engineering and Technology , Harbin Institute of Technology , Harbin , China ;
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Han
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000737:chemistry; D005472:Fluorouracil / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000737:chemistry*; D007668:Kidney / Q000187:drug effects; D007680:Kidney Neoplasms / Q000188:drug therapy; D008081:Liposomes / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D007211:Indoles; D008081:Liposomes; D011108:Polymers; C568283:polydopamine; D005472:Fluorouracil
keywords: 5-FU; Liposome; controlled drug release; pH sensitive; poly dopamine