title: Incorporation of gallium-68 into the crystal structure of Prussian blue to form K(68)GaxFe1-x[Fe(CN)6] nanoparticles: toward a novel bimodal PET/MRI imaging agent.
abstract: Similarity between the Ga(+) ion and the Fe(3+) ion allows for partial replacement of Fe(3+) ions with Ga(3+) ions in the Fe(iii) crystallographic positions in Prussian blue (PB) to form various solid solutions KGaxFe1-x[Fe(CN)6] (0 < x < 1). Such solid solutions possess very high thermodynamic stability as expected from the parent PB structure. Consequently, a simple one-step (68)Ga-labeling method was developed for preparing a single-phase nanoparticulate bimodal PET/MRI imaging agent based on the PB structural platform. Unlike the typical (68)Ga-labelling reaction based on metal complexation, this novel chelator-free (68)Ga-labeling reaction was shown to be kinetically fast under the acidic conditions. The Ga(3+) ion does not hydrolyze, and affords the (68)Ga-labelled PB nanoparticles, which are easy to purify and have extremely high stability against radionuclidic leaching in aqueous solution.
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu.
authors.forename: Murthi S
authors.initials: MS
authors.lastname: Kandanapitiye
authors.affiliation: Department of Chemistry, University of Missouri, Columbia, MO 65211, USA.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Gott
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Sharits
authors.affiliation: Department of Chemistry, University of Missouri, Columbia, MO 65211, USA.
authors.forename: Silvia S
authors.initials: SS
authors.lastname: Jurisson
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Woodward
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu.
authors.forename: Songping D
authors.initials: SD
authors.lastname: Huang