title: Gold(i) catalyzed tandem cyclization of propargylic esters to 4-acyloxy-1,2-dihydroquinolines.
abstract: An effective synthetic protocol for structurally diverse 4-acyloxy-1,2-dihydroquinoline compounds has been accomplished by a gold(i)-catalyzed tandem [3,3]-rearrangement and intramolecular hydroamination of propargylic esters, affording the desired products in good yields. Moreover, the asymmetric variant of this cyclization has also been achieved using a chiral nitrogen acyclic carbene (NAC) gold(i) complex. These products have application in the enantioselective synthesis of an aromatase inhibitor within three simple steps.
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, and 130 MeiLong Road, Shanghai 200237, P. R. China.
authors.forename: Yuan-Ming
authors.initials: YM
authors.lastname: Sun
authors.forename: Peng
authors.initials: P
authors.lastname: Gu
authors.forename: Yu-Ning
authors.initials: YN
authors.lastname: Gao
authors.forename: Qin
authors.initials: Q
authors.lastname: Xu
authors.forename: Min
authors.initials: M
authors.lastname: Shi