title: Fetal programming and early identification of newborns at high risk of free radical-mediated diseases.
abstract: Nowadays metabolic syndrome represents a real outbreak affecting society. Paradoxically, pediatricians must feel involved in fighting this condition because of the latest evidences of developmental origins of adult diseases. Fetal programming occurs when the normal fetal development is disrupted by an abnormal insult applied to a critical point in intrauterine life. Placenta assumes a pivotal role in programming the fetal experience in utero due to the adaptive changes in structure and function. Pregnancy complications such as diabetes, intrauterine growth restriction, pre-eclampsia, and hypoxia are associated with placental dysfunction and programming. Many experimental studies have been conducted to explain the phenotypic consequences of fetal-placental perturbations that predispose to the genesis of metabolic syndrome, obesity, diabetes, hyperinsulinemia, hypertension, and cardiovascular disease in adulthood. In recent years, elucidating the mechanisms involved in such kind of process has become the challenge of scientific research. Oxidative stress may be the general underlying mechanism that links altered placental function to fetal programming. Maternal diabetes, prenatal hypoxic/ischaemic events, inflammatory/infective insults are specific triggers for an acute increase in free radicals generation. Early identification of fetuses and newborns at high risk of oxidative damage may be crucial to decrease infant and adult morbidity.
authors.affiliation: Serafina Perrone, Antonino Santacroce, Anna Picardi, Giuseppe Buonocore, Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
authors.forename: Serafina
authors.initials: S
authors.lastname: Perrone
authors.affiliation: Serafina Perrone, Antonino Santacroce, Anna Picardi, Giuseppe Buonocore, Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Santacroce
authors.affiliation: Serafina Perrone, Antonino Santacroce, Anna Picardi, Giuseppe Buonocore, Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Picardi
authors.affiliation: Serafina Perrone, Antonino Santacroce, Anna Picardi, Giuseppe Buonocore, Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Buonocore
keywords: Biomarkers; Fetal programming; High-risk newborn; Metabolic syndrome; Oxidative stress; Perinatal medicine