title: Comparative proteomics of milk fat globule membrane in goat colostrum and mature milk.
abstract: As an important nutrient source in large area of world, the composition and nutritional value of goat milk are not well deliberated. Detailed annotation of protein composition is essential to address the physiological and nutritional value of goat milk. In the present study, 423 colostrum and mature goat milk fat globule membrane (MFGM) proteins were identified. The abundance of 189 proteins was significantly different between colostrums and mature milk MFGM. The acute phase proteins were higher in colostrums MFGM than those in mature milk MFGM which protected newborns at the beginning of life. Proteins related to synthesis and secretion were conserved through lactation to ensure the milk production. Of note, long term depression (LTD) proteins were observed in colostrum and mature milk MFGM. Milk LTD proteins could be potential biomarkers for diagnosis of lactation related depressive syndromes and should be taken into considerations of their effects on newborns.
authors.affiliation: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.affiliation: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.affiliation: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Pang
authors.affiliation: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Shuwen
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Zhenhu
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Changlu
authors.initials: C
authors.lastname: Ma
authors.affiliation: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, China. Electronic address: kjdairy@126.com.
authors.forename: Jiaping
authors.initials: J
authors.lastname: Lv
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000818:Animals; D002853:Chromatography, Liquid; D003126:Colostrum / Q000378:metabolism*; D005260:Female; D006017:Glycolipids / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism*; D006041:Goats; D007774:Lactation; D066292:Lipid Droplets; D008565:Membrane Proteins / Q000032:analysis* / Q000378:metabolism; D008892:Milk / Q000378:metabolism; D008894:Milk Proteins / Q000378:metabolism*; D009753:Nutritive Value; D011247:Pregnancy; D040901:Proteomics / Q000379:methods*; D053719:Tandem Mass Spectrometry
chemical_list: D000209:Acute-Phase Proteins; D006017:Glycolipids; D006023:Glycoproteins; D008565:Membrane Proteins; D008894:Milk Proteins; C110367:milk fat globule
keywords: Acute phase response proteins; Colostrum; Goat MFGM; Long term depression; Mature milk