title: Monitoring of Intracranial Pressure in Meningitis.
abstract: The literature on intracranial pressure (ICP) monitoring in meningitis is limited to case reports and a handful of descriptive series. The aim of this study is to investigate relationships among ICP, cerebral perfusion pressure (CPP), and outcome in meningitis and to identify whether ICP affected clinical decisions.
  
  
  
  Between 1999 and 2011, a total of 17 patients with meningitis underwent ICP monitoring at the University Hospitals Leuven. Charts were reviewed for clinical history, ICP/CPP data, imaging findings, and Glasgow Outcome Scale score. Univariate correlations were computed for outcome and ICP/CPP variables, computed tomography characteristics, and Corticosteroid Randomization After Significant Head Injury outcome model variables. Treatment decisions were assessed regarding whether or not they were based on ICP.
  
  
  
  At drain placement, Glasgow Coma Scale scores showed a median of 8 (range 3-12). Six of 17 patients had either one or two nonreactive pupils. Significant correlations with outcome were found for the highest documented ICP value (r = -0.70), the number of episodes when CPP <50 mmHg (r =-0.50), the lowest documented CPP value (r = 0.61), and pupil reactivity (r = 0.57). Treatment was influenced by ICP in all patients.
  
  
  
  The results support the notion that in meningitis high ICP and low CPP represent secondary insults. The poor condition of the patients illustrates that the level of suspicion for increased ICP in meningitis may not be high enough.
authors.affiliation: Neurosurgery, University Hospitals Leuven, Herestraat 49, Leuven, 3000, Belgium. bart.depreitere@uzleuven.be.
authors.forename: Bart
authors.initials: B
authors.lastname: Depreitere
authors.affiliation: Neurosurgery, University Hospitals Leuven, Herestraat 49, Leuven, 3000, Belgium.
authors.forename: Dominike
authors.initials: D
authors.lastname: Bruyninckx
authors.affiliation: Intensive Care Medicine, University Hospitals Leuven, Herestraat 49, Leuven, 3000, Belgium.
authors.forename: Fabian
authors.initials: F
authors.lastname: Güiza
mesh_terms: D002560:Cerebrovascular Circulation; D000066491:Clinical Decision-Making; D015600:Glasgow Coma Scale; D023261:Glasgow Outcome Scale; D006801:Humans; D019586:Intracranial Hypertension / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D019585:Intracranial Hypotension / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D007427:Intracranial Pressure; D008581:Meningitis / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008991:Monitoring, Physiologic; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
keywords: Cerebral perfusion pressure; Intensive care; Intracranial pressure; Meningitis; Monitoring