title: Contrast-induced nephropathy in outpatients with preexisting renal impairment: a comparison between intravenous iohexol and iodixanol.
abstract: BACKGROUND
  Concern for contrast-induced nephropathy (CIN) may result in administration of more costly agents. We prospectively compared outpatient CIN incidence of iodixanol to iohexol.
  
  
  METHODS
  Patients were randomized to receive 100ml of iohexol (n=47) or iodixanol (n=55). We compared patients who developed CIN using the Wilson score interval and also calculated an odds ratio for the development of CIN.
  
  
  RESULTS
  CIN rate for iohexol was 2% compared to 9% for iodixanol. Those receiving iodixanol were almost 5 times more likely to experience CIN.
  
  
  CONCLUSIONS
  These results do not suggest a benefit of iodixanol over iohexol in the study population.
authors.affiliation: Department of Radiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224. Electronic address: cernigliaro.joseph@mayo.edu.
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Cernigliaro
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224; Department of Health Sciences Research, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224.
authors.forename: William E
authors.initials: WE
authors.lastname: Haley
authors.affiliation: Department of Radiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224.
authors.forename: Doug P
authors.initials: DP
authors.lastname: Adolphson
authors.affiliation: Department of Radiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Jepperson
authors.affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224.
authors.forename: Julia E
authors.initials: JE
authors.lastname: Crook
authors.affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224.
authors.forename: Colleen S
authors.initials: CS
authors.lastname: Thomas
authors.affiliation: Division of Epidemiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224.
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Parker
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005431:Florida / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007275:Injections, Intravenous; D007472:Iohexol / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D011379:Prognosis; D051437:Renal Insufficiency / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D014057:Tomography, X-Ray Computed / Q000009:adverse effects* / Q000379:methods; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C044834:iodixanol
keywords: Contrast nephropathy (CIN); Iodixanol; Iohexol; Outpatient