title: [The therapeutic effects of dietary krill oil (Euphausia superba) supplementation on oxidative stress and DNA damages markers in cafeteria diet-overfed rats].
abstract: OBJECTIVE
  To evaluate the therapeutic effects of dietary krill oil supplementation in modulation of oxidative stress components and DNA oxidative damages marker in cafeteria diet-overfed-rats.
  
  
  METHODS
  Eighteen aging male Wistar rats were divided into three groups of six each and were exposed for the ensuing 8 weeks to one of the diets: control group (TS) which was submitted to standard chow (330kcal/100g), containing 24% of proteins, 5% of lipids and 70% of carbohydrates. Cafeteria standard group (TC) exposed to cafeteria diet (420kcal/100g). The last group received a cafeteria diet enriched in oral force-feeding krill oil 2% (CK). The plasma and tissues pro-oxydant status were assessed by assaying thiobarbituric acid reactive substances, hydroperoxydes, and isoprostans. The determination of DNA oxidative damages was evaluated by the measurement of the major products of DNA oxidation (8-OHdG).
  
  
  RESULTS
  Exposure to a cafeteria diet increases the metabolic response to the radical attack and DNA oxidative damages in both plasma and key tissues involved in antioxidant defense. Krill oil supplementation in cafeteria diet relieves oxidative stress and DNA damages by lowering several lipid peroxidation components and the main marker of DNA oxidation in obese rats.
authors.affiliation: Département de biologie, laboratoire de biochimie clinique et métabolique, université d'Oran 1 Ahmed Ben Bella, BP 1524, El M'Naouer, 31100 Oran, Algérie. Electronic address: zoheir.m@netcourrier.com.
authors.forename: Z
authors.initials: Z
authors.lastname: Mellouk
authors.affiliation: Unité de recherche, nutrition et maladies métaboliques, université d'Alicante, 03690 Alicante, Espagne.
authors.forename: M
authors.initials: M
authors.lastname: Agustina
authors.affiliation: Unité de recherche, nutrition et maladies métaboliques, université d'Alicante, 03690 Alicante, Espagne.
authors.forename: M
authors.initials: M
authors.lastname: Ramirez
authors.affiliation: Unité de recherche, nutrition et maladies métaboliques, université d'Alicante, 03690 Alicante, Espagne.
authors.forename: K
authors.initials: K
authors.lastname: Pena
authors.affiliation: Unité de recherche, nutrition et maladies métaboliques, université d'Alicante, 03690 Alicante, Espagne.
authors.forename: J
authors.initials: J
authors.lastname: Arivalo
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology; D004249:DNA Damage / Q000187:drug effects*; D059305:Diet, High-Fat; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000494:pharmacology; D004195:Disease Models, Animal; D033201:Euphausiacea; D008297:Male; D009765:Obesity / Q000097:blood / Q000178:diet therapy*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D004042:Dietary Fats, Unsaturated
keywords: 8-OHdG; Cafeteria diet; Dyslipidemia; Dyslipidémie; Huile de krill; Krill oil; Obesity; Obésité; Oxidative stress; Rat; Régime cafétéria; Stress oxydant