title: Interaction of Atmospheric-Pressure Air Microplasmas with Amino Acids as Fundamental Processes in Aqueous Solution.
abstract: Plasma medicine is a relatively new field that investigates potential applications of cold atmospheric-pressure plasmas in bioengineering, such as for bacterial inactivation and degradation of organic molecules in water. In order to enunciate mechanisms of bacterial inactivation at molecular or atomic levels, we investigated the interaction of atmospheric-pressure air microplasmas with amino acids in aqueous solution by using high-resolution mass spectrometry (HRMS). Results show that the oxidation effect of plasma-induced species on the side chains of the amino acids can be categorized into four types, namely hydroxylation, nitration, dehydrogenation and dimerization. In addition, relative activities of amino acids resulting from plasma treatment come in descending order as follows: sulfur-containing carbon-chain amino acids > aromatic amino acids > five-membered ring amino acids > basic carbon-chain amino acids. Since amino acids are building blocks of proteins vital to the growth and reproduction of bacteria, these results provide an insight into the mechanism of bacterial inactivation by plasma.
authors.affiliation: Liaoning Key Laboratory of Optoelectronic Films & Materials, School of Physics and Materials Engineering, Dalian Nationalities University, Dalian, 116600, China.|School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, Queensland, 4000, Australia.|Fujian Key Laboratory for Plasma and Magnetic Resonance, School of Physics and Mechanical & Electrical Engineering, Xiamen University, Xiamen, 361005, China.|CSIRO-QUT Joint Sustainable Materials and Devices Laboratory, Commonwealth Scientific and Industrial Research Organisation, P.O.Box 218, Lindfield, NSW, 2070, Australia.
authors.forename: Renwu
authors.initials: R
authors.lastname: Zhou
authors.affiliation: Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
authors.forename: Rusen
authors.initials: R
authors.lastname: Zhou
authors.affiliation: Fujian Key Laboratory for Plasma and Magnetic Resonance, School of Physics and Mechanical & Electrical Engineering, Xiamen University, Xiamen, 361005, China.|School of Information Technology and Management, University of International Business and Economics, Beijing, 10000, China.
authors.forename: Jinxing
authors.initials: J
authors.lastname: Zhuang
authors.affiliation: Liaoning Key Laboratory of Optoelectronic Films & Materials, School of Physics and Materials Engineering, Dalian Nationalities University, Dalian, 116600, China.
authors.forename: Zichao
authors.initials: Z
authors.lastname: Zong
authors.affiliation: Fujian Key Laboratory for Plasma and Magnetic Resonance, School of Physics and Mechanical & Electrical Engineering, Xiamen University, Xiamen, 361005, China.
authors.forename: Xianhui
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Liaoning Key Laboratory of Optoelectronic Films & Materials, School of Physics and Materials Engineering, Dalian Nationalities University, Dalian, 116600, China.|Fujian Key Laboratory for Plasma and Magnetic Resonance, School of Physics and Mechanical & Electrical Engineering, Xiamen University, Xiamen, 361005, China.
authors.forename: Dongping
authors.initials: D
authors.lastname: Liu
authors.affiliation: School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, Queensland, 4000, Australia.|CSIRO-QUT Joint Sustainable Materials and Devices Laboratory, Commonwealth Scientific and Industrial Research Organisation, P.O.Box 218, Lindfield, NSW, 2070, Australia.
authors.forename: Kateryna
authors.initials: K
authors.lastname: Bazaka
authors.affiliation: School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, Queensland, 4000, Australia.|CSIRO-QUT Joint Sustainable Materials and Devices Laboratory, Commonwealth Scientific and Industrial Research Organisation, P.O.Box 218, Lindfield, NSW, 2070, Australia.
authors.forename: Kostya
authors.initials: K
authors.lastname: Ostrikov
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D017665:Hydroxyl Radical / Q000737:chemistry; D013058:Mass Spectrometry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010126:Ozone / Q000737:chemistry; D058626:Plasma Gases / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry*; D013696:Temperature; D014867:Water / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D058626:Plasma Gases; D012996:Solutions; D014867:Water; D017665:Hydroxyl Radical; D010126:Ozone; D006861:Hydrogen Peroxide