title: Bisphosphonates can prevent recurrent hip fracture and reduce the mortality in osteoporotic patient with hip fracture: A meta-analysis.
abstract: OBJECTIVE
  This meta-analysis was conducted to investigate the efficacy of bisphosphonates for preventing recurrent hip fracture and reducing the mortality of elderly patient with hip fracture.
  
  
  METHODS
  The databases of Pubmed, Embase and Cochrane Library were searched. All randomized or prospective matched controlled trials that assessed the efficacy of bisphosphonate for elderly patients with hip fracture were included. Two researchers independently extracted data of the included articles and assessed the methodological quality which was assessed based on Jadad scoring system or Newcastle-Ottawa scale. The second hip fracture incidence, mortality and complications were compared between bisphosphonates and control groups.
  
  
  RESULTS
  Four studies including 3088 patients were included. Results showed that there were significant difference of second hip fracture (P<0.05) and mortality (P<0.05) between bisphosphonates group and control group. While no significant intergroup difference were observed for all complications.
  
  
  CONCLUSIONS
  Bisphosphonates can prevent subsequent hip fracture, reduce the mortality, and does not increase the overall complications in elderly patients with hip fracture.
authors.affiliation: Jing Peng, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Peng
authors.affiliation: Yong Liu, Department of Orthopedics, Bao Ji Central Hospital, Bao Ji, Shan Xi, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Long Chen, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Long
authors.initials: L
authors.lastname: Chen
authors.affiliation: Kun Peng, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Peng
authors.affiliation: Zhao Xu, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Dagang Zhang, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Dagang
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Zhou Xiang, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Xiang
keywords: Bisphosphonate; Hip fracture; Osteoporosis