title: Modulation of retinal image vasculature analysis to extend utility and provide secondary value from optical coherence tomography imaging.
abstract: Retinal image analysis is emerging as a key source of biomarkers of chronic systemic conditions affecting the cardiovascular system and brain. The rapid development and increasing diversity of commercial retinal imaging systems present a challenge to image analysis software providers. In addition, clinicians are looking to extract maximum value from the clinical imaging taking place. We describe how existing and well-established retinal vasculature segmentation and measurement software for fundus camera images has been modulated to analyze scanning laser ophthalmoscope retinal images generated by the dual-modality Heidelberg SPECTRALIS(®) instrument, which also features optical coherence tomography.
authors.affiliation: University of Edinburgh, Anne Rowling Regenerative Neurology Clinic, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom; University of Edinburgh, Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom.
authors.forename: James R
authors.initials: JR
authors.lastname: Cameron
authors.affiliation: University of Edinburgh, Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom; University of Edinburgh, Clinical Research Imaging Centre, VAMPIRE Project, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom.
authors.forename: Lucia
authors.initials: L
authors.lastname: Ballerini
authors.affiliation: University of Edinburgh , College of Medicine and Veterinary Medicine, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom.
authors.forename: Clare
authors.initials: C
authors.lastname: Langan
authors.affiliation: University of Edinburgh , College of Medicine and Veterinary Medicine, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom.
authors.forename: Claire
authors.initials: C
authors.lastname: Warren
authors.affiliation: University of Edinburgh , College of Medicine and Veterinary Medicine, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Denholm
authors.affiliation: University of Edinburgh , College of Medicine and Veterinary Medicine, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom.
authors.forename: Katie
authors.initials: K
authors.lastname: Smart
authors.affiliation: University of Edinburgh, Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom; University of Edinburgh, Clinical Research Imaging Centre, VAMPIRE Project, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: MacGillivray
keywords: image analysis; ophthalmology; retina; scanning laser ophthalmoscope