title: Microdomains Associated to Lipid Rafts.
abstract: Store Operated Ca(2+) Entry (SOCE), the main Ca(2+) influx mechanism in non-excitable cells, is implicated in the immune response and has been reported to be affected in several pathologies including cancer. The basic molecular constituents of SOCE are Orai, the pore forming unit, and STIM, a multidomain protein with at least two principal functions: one is to sense the Ca(2+) content inside the lumen of the endoplasmic reticulum(ER) and the second is to activate Orai channels upon depletion of the ER. The link between Ca(2+) depletion inside the ER and Ca(2+) influx from extracellular media is through a direct association of STIM and Orai, but for this to occur, both molecules have to interact and form clusters where ER and plasma membrane (PM) are intimately apposed. In recent years a great number of components have been identified as participants in SOCE regulation, including regions of plasma membrane enriched in cholesterol and sphingolipids, the so called lipid rafts, which recruit a complex platform of specialized microdomains, which cells use to regulate spatiotemporal Ca(2+) signals.
authors.affiliation: Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, México, DF, 04510, Mexico.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Pacheco
authors.affiliation: Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, México, DF, 04510, Mexico.
authors.forename: Josué O
authors.initials: JO
authors.lastname: Ramírez-Jarquín
authors.affiliation: Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, México, DF, 04510, Mexico. lvaca@ifc.unam.mx.
authors.forename: Luis
authors.initials: L
authors.lastname: Vaca
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D050052:TRPC Cation Channels / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; D050052:TRPC Cation Channels
keywords: ER/PM junction; Lipid rafts; Orai1; SOCE; STIM1; TRPC channels