title: [Human growth hormone and Turner syndrome].
abstract: OBJECTIVE
  The evaluation of clinical and analytical parameters as predictors of the final growth response in Turner syndrome patients treated with growth hormone.
  
  
  METHODS
  A retrospective study was performed on 25 girls with Turner syndrome (17 treated with growth hormone), followed-up until adult height. Auxological, analytical, genetic and pharmacological parameters were collected. A descriptive and analytical study was conducted to evaluate short (12 months) and long term response to treatment with growth hormone.
  
  
  RESULTS
  A favourable treatment response was shown during the first year of treatment in terms of height velocity gain in 66.6% of cases (height-gain velocity >3cm/year). A favourable long-term treatment response was also observed in terms of adult height, which increased by 42.82±21.23cm (1.25±0.76 SDS), with an adult height gain of 9.59±5.39cm (1.68±1.51 SDS).
  
  
  CONCLUSIONS
  Predictors of good response to growth hormone treatment are: A) initial growth hormone dose, B) time on growth hormone treatment until starting oestrogen therapy, C) increased IGF1 and IGFBP-3 levels in the first year of treatment, and D) height gain velocity in the first year of treatment.
authors.affiliation: Unidad de Endocrinología Pediátrica, Hospital Universitario Miguel Servet, Zaragoza, España. Electronic address: ssanchezmarco@gmail.com.
authors.forename: Silvia Beatriz
authors.initials: SB
authors.lastname: Sánchez Marco
authors.affiliation: Unidad de Endocrinología Pediátrica, Hospital Universitario Miguel Servet, Zaragoza, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: de Arriba Muñoz
authors.affiliation: Unidad de Endocrinología Pediátrica, Hospital Universitario Miguel Servet, Zaragoza, España.
authors.forename: Marta
authors.initials: M
authors.lastname: Ferrer Lozano
authors.affiliation: Unidad de Endocrinología Pediátrica, Hospital Universitario Miguel Servet, Zaragoza, España.
authors.forename: José Ignacio
authors.initials: JI
authors.lastname: Labarta Aizpún
authors.affiliation: Servicio de Pediatría, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
authors.forename: Jesús María
authors.initials: JM
authors.lastname: Garagorri Otero
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D011994:Recombinant Proteins / Q000627:therapeutic use; D012189:Retrospective Studies; D014424:Turner Syndrome / Q000188:drug therapy*
chemical_list: D011994:Recombinant Proteins; D019382:Human Growth Hormone
keywords: Growth hormone; Hormona de crecimiento; Short stature; Síndrome de Turner; Talla baja; Turner syndrome