title: [INFLAMMATION AND CARDIAC INSUFFICIENCY ASSOCIATED WITH INFECTIOUS ENDOCARDITIS].
abstract: The study included 62 patients with uncomplicated primary and secondary infectious endocarditis admitted to S.PBotkin city hospital from 2011 to 2014. The emphasis is laid on diagnostic significance of dynamic measurements of the levels of C-reactive protein, tumour necrosis factor and highly sensitive troponin-1 for the evaluation of activity of the infectious/toxic process, severity of the disease, and detection of complications. The study revealed the relationship of the enhanced level of troponin-1 with changes of inflammation markers, morphofunctional characteristics of myocardium, and circulatory failure. Morphologicl study demonstrated inflammatory and dystrophic changes in myocardium, focal and diffuse cardiofibrosis suggesting development of non-coronarogenic myocardial lesions that play an important role in the progress of cardiac failure associated with infectious endocarditis.
authors.forename: T A
authors.initials: TA
authors.lastname: Fedorova
authors.forename: S Ya
authors.initials: SY
authors.lastname: Tazina
authors.forename: L V
authors.initials: LV
authors.lastname: Kaktursky
authors.forename: T D
authors.initials: TD
authors.lastname: Kanareitseva
authors.forename: N I
authors.initials: NI
authors.lastname: Stefanenko
authors.forename: V I
authors.initials: VI
authors.lastname: Burtsev
authors.forename: N A
authors.initials: NA
authors.lastname: Semenenko
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002317:Cardiovascular Agents / Q000627:therapeutic use; D004452:Echocardiography; D004696:Endocarditis / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D017063:Outcome Assessment, Health Care; D012720:Severity of Illness Index; D013223:Statistics as Topic; D019210:Troponin I / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; D002317:Cardiovascular Agents; D019210:Troponin I; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein