title: Clinical considerations on the posology of direct oral anticoagulants.
abstract: The efficacy of dicoumarin anticoagulants has been shown in patients with nonvalvular atrial fibrillation. However, they have drawbacks such as the need to adjust the dosage and the interaction with drugs and food. Direct oral anticoagulants are an effective and safe alternative and have a less complicated clinical management. There is considerable debate on the selection criteria for the posology regimens of direct oral anticoagulants. The differences among them and their administration regimens have raised questions about the clinical, pharmacokinetic and pharmacodynamic selection criteria that support the posology. This review critically analyses the available evidence and its impact on the final selection of the dosage regimen.
authors.affiliation: Servicio de Farmacología Clínica, Hospital Clínic de Barcelona, Barcelona, España. Electronic address: jsaez@clinic.ub.es.
authors.forename: J
authors.initials: J
authors.lastname: Sáez-Peñataro
authors.affiliation: Servicio de Farmacología Clínica, Hospital Puerta de Hierro Majadahonda, Madrid, España.
authors.forename: C
authors.initials: C
authors.lastname: Avendaño-Solá
authors.affiliation: Servicio de Cardiología, Hospital Clínico Universitario de Santiago de Compostela , Santiago de Compostela, España; Departamento de Medicina, Facultad de Medicina y Odontología, Universidad de Santiago de Compostela, Santiago de Compostela, España.
authors.forename: J R
authors.initials: JR
authors.lastname: González-Juanatey
keywords: Administration regimen; Atrial fibrillation; Esquema de administración; Factor Xa inhibitors; Farmacocinética; Farmacodinamia; Fibrilación auricular; Inhibidores del factor Xa; Pharmacodynamics; Pharmacokinetics