title: A Case of Good's Syndrome Presenting with Pulmonary Tuberculosis.
abstract: Adult onset immunodeficiency associated with thymoma is a rare condition. The combination of hypogammaglobulinemia, reduced number of peripheral B and CD4+ T cells, along with thymoma constitutes Good's syndrome (GS). This immunodeficiency condition is often complicated with opportunistic infection with organisms, like bacteria (Haemophilus influenzae, Streptococcus pneumonia etc), viruses (Cytomegalovirus, Herpes simplex etc), fungi and protozoa. We present an unusual case of Good's syndrome with pulmonary tuberculosis (PTB). A 40-year-old man presented with sputum-positive PTB and was started on anti-tuberculosis treatment. Subsequently, he developed symptoms and findings consistent with thymoma and other components of Good's syndrome. Although patients of Good's syndrome are susceptible to various opportunistic infections, infection with Mycobacterium tuberculosis is uncommon. Evidence of recurrent infections or some opportunistic infection in a thymoma patient should trigger a suspicion of Good's syndrome.
authors.forename: Arunabha Datta
authors.initials: AD
authors.lastname: Chaudhuri
authors.forename: Sumit Roy
authors.initials: SR
authors.lastname: Tapadar
authors.forename: Aparup
authors.initials: A
authors.lastname: Dhua
authors.forename: Palash Nandan
authors.initials: PN
authors.lastname: Dhara
authors.forename: Saumen
authors.initials: S
authors.lastname: Nandi
authors.forename: Sabyasachi
authors.initials: S
authors.lastname: Choudhury
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage*; D018791:CD4 Lymphocyte Count; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis*; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D011859:Radiography; D013183:Sputum / Q000382:microbiology; D013934:Thymectomy / Q000379:methods*; D013945:Thymoma / Q000150:complications / Q000175:diagnosis / Q000276:immunology / Q000601:surgery; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000995:Antitubercular Agents