title: Recent advances in understanding Kaposi's sarcoma-associated herpesvirus.
abstract: Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is an oncogenic human herpesvirus. KSHV is associated with three cancers in the human population: KS, primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KS is the leading cause of cancer in HIV-infected individuals. In this review, we discuss the most recent discoveries behind the mechanisms of KSHV latency maintenance and lytic replication. We also review current therapies for KSHV-associated cancers.
authors.affiliation: Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: Dissinger
authors.affiliation: Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Blossom
authors.initials: B
authors.lastname: Damania
keywords: KSHV; Kaposi’s sarcoma-associated herpesvirus; multicentric Castleman’s disease; primary effusion lymphoma