title: Polymeric Thioxanthones as Potential Anticancer and Radiotherapy Agents.
abstract: Thioxanthone (TX) and its derivatives, which are widely used as photoinitiators in UV curing technology, hold promising research interest in biological applications. In particular, the use of TXs as anticancer agent has recently been manifested as an outstanding additional property of this class of molecules. Incorporation of TX molecules into specially designed polymers widens their practical use in such applications. In this study, two water-soluble, biocompatible, and stable polymers, namely poly(vinyl alcohol) and poly(ethylene glycol), possessing TX moieties at the side chains and chain ends, respectively, are prepared and used as anticancer and radiotherapy agents. The findings confirm that both polymers are potential candidates for therapeutic agents as they possess useful features including water-solubility, radiosensitizer effect, and anticancer activity in a polymeric scaffold.
authors.affiliation: Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, 34469, Istanbul, Turkey.
authors.forename: Gorkem
authors.initials: G
authors.lastname: Yilmaz
authors.affiliation: Biochemistry Department, Faculty of Science Ege University, 35100, Bornova, Izmir, Turkey.|Institute of Drug Abuse Toxicology and Pharmaceutical Sciences, Ege University, 35100, Bornova, Izmir, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Guler
authors.affiliation: Biochemistry Department, Faculty of Science Ege University, 35100, Bornova, Izmir, Turkey.
authors.forename: Firat Baris
authors.initials: FB
authors.lastname: Barlas
authors.affiliation: Biochemistry Department, Faculty of Science Ege University, 35100, Bornova, Izmir, Turkey.|Institute of Drug Abuse Toxicology and Pharmaceutical Sciences, Ege University, 35100, Bornova, Izmir, Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Timur
authors.affiliation: Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, 34469, Istanbul, Turkey.|Chemistry Department Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yagci
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D059248:Chemoradiotherapy; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011142:Polyvinyl Alcohol / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013892:Thioxanthenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D044004:Xanthones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D013892:Thioxanthenes; D044004:Xanthones; D011092:Polyethylene Glycols; D011142:Polyvinyl Alcohol; C484911:thioxanthone
keywords: anticancer; cytotoxicity; poly(ethylene glycol); poly(vinyl alcohol); radiotherapy; thioxanthones