title: Association between interleukin-19 and angiopoietin-2 with vascular complications in type 2 diabetes.
abstract: OBJECTIVE
  The aim of the present study was to investigate the role of interleukin-19 (IL-19) in angiogenesis of type 2 diabetes mellitus with complications, and to assess the relationship of serum IL-19 and angiopoietin-2 (Ang-2) in type 2 diabetes mellitus.
  
  
  METHODS
  The group studied comprised of 240 patients with type 2 diabetes mellitus (132 men and 108 women), and included macrovascular complications, microvascular complications and type 2 diabetes mellitus without vascular complications. The control group consisted of 50 healthy blood donors. All participants were evaluated for: IL-19, Ang-2, fasting plasma glucose, fasting insulin and glycosylated hemoglobin.
  
  
  RESULTS
  The serum IL-19 levels of type 2 diabetes mellitus patients with angiopathy were found to be significantly higher compared with patients without angiopathy. IL-19 levels were significantly positively correlated with Ang-2, homeostasis model assessment for insulin resistance and glycosylated hemoglobin (r = 0.769, 0.523 and 0.491, respectively, P < 0.01). In multivariable logistic regression analysis, IL-19 levels (P = 0.01) were found to be independently associated with patients with type 2 diabetes mellitus complications.
  
  
  CONCLUSIONS
  These data are the first to implicate the association between the IL-19 and type 2 diabetes mellitus with vascular complications. IL-19 is significantly positively correlated with Ang-2. The potential role of IL-19 and Ang-2 in the pathogenesis of vascular complications in type 2 diabetes could warrant further study.
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China. bhxylili@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: ZHeng-Qing
authors.affiliation: Department of Clinical Laboratory, Binhai County Second Hospital, Binhai, Jiangsu Province, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Juan-Yu
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Jian-Yong
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Fan
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Guang-Chun
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Lei
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Gu
authors.initials: G
authors.lastname: Hui-Ming
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Si-Jing
authors.affiliation: Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Meng
mesh_terms: D000368:Aged; D042702:Angiopoietin-2 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000150:complications*
chemical_list: D042702:Angiopoietin-2; D006442:Glycated Hemoglobin; D007378:Interleukins; C586513:ANGPT2 protein, human; C421250:IL19 protein, human; C517652:hemoglobin A1c protein, human
keywords: Angiopoietin-2; Interleukin-19; Vascular complications