title: [Weakness of the extremities in a 73-year-old male patient].
abstract: A patient undergoing cyclosporine therapy presented with muscle weakness. This was preceded by diarrhea and treated with ciprofloxacin. Rhabdomyolysis was diagnosed clinically and biochemically. This was presumably drug-induced triggered by a combined therapy with cyclosporine, amlodipine, simvastatin and ciprofloxacin. The case presented demonstrates that during therapy with several substances which inhibit the degradation of simvastatin, the additional administration of ciprofloxacin should be considered with extreme caution.
authors.affiliation: Klinik für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland. attaran.masoumeh@mh-hannover.de.
authors.forename: M
authors.initials: M
authors.lastname: Attaran-Bandarabadi
authors.affiliation: Abteilung Neurologie, Klinikum Braunschweig, Braunschweig, Deutschland.
authors.forename: P
authors.initials: P
authors.lastname: Kalbasi Anaraki
authors.affiliation: Zentrum für Innere Medizin, Klinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Hannover, Deutschland.
authors.forename: W
authors.initials: W
authors.lastname: Gwinner
authors.affiliation: Zentrum für Innere Medizin, Klinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Hannover, Deutschland.
authors.forename: H
authors.initials: H
authors.lastname: Haller
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination / Q000009:adverse effects*; D005121:Extremities; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D018908:Muscle Weakness / Q000139:chemically induced* / Q000175:diagnosis* / Q000517:prevention & control; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000175:diagnosis* / Q000517:prevention & control
chemical_list: D007166:Immunosuppressive Agents
keywords: Amlodipine; Ciprofloxacin; Cyclosporin; Rhabdomyolysis; Simvastatin