title: Association between physical activity and bone in children with Prader-Willi syndrome.
abstract: BACKGROUND
  The aim of the study was to determine if physical activity (PA) is associated with bone health in children with Prader-Willi syndrome (PWS).
  
  
  METHODS
  Participants included 23 children with PWS (age: 11.0±2.0 years). PA, measured by accelerometry, was categorized into light, moderate, vigorous and moderate plus vigorous intensities. Hip, total body minus the head (body), bone mineral content (BMC), bone mineral density (BMD) and BMD z-score (BMDz) were measured by dual X-ray absorptiometry. Separate hierarchical regression models were completed for all bone parameters, PA intensity and select covariates.
  
  
  RESULTS
  Moderate PA and select covariates explained the most variance in hip BMC (84.0%), BMD (61.3%) and BMDz (34.9%; p<0.05 for all). Likewise, for each body parameter, moderate PA and select covariates explained the most variance in body BMC (75.8%), BMD (74.4%) and BMDz (31.8%; p<0.05 for all).
  
  
  CONCLUSIONS
  PA of at least moderate intensity appears important for BMC and BMD in children with PWS.
authors.forename: Andrea T
authors.initials: AT
authors.lastname: Duran
authors.forename: Kathleen S
authors.initials: KS
authors.lastname: Wilson
authors.forename: Diobel M
authors.initials: DM
authors.lastname: Castner
authors.forename: Jared M
authors.initials: JM
authors.lastname: Tucker
authors.forename: Daniela A
authors.initials: DA
authors.lastname: Rubin
mesh_terms: D015502:Absorptiometry, Photon; D061725:Accelerometry; D000293:Adolescent; D015992:Body Mass Index; D015519:Bone Density; D002648:Child; D003430:Cross-Sectional Studies; D004032:Diet / Q000009:adverse effects; D015930:Diet Records; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000150:complications* / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D050177:Overweight / Q000150:complications* / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D010290:Parents; D063766:Pediatric Obesity / Q000150:complications* / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D011218:Prader-Willi Syndrome / Q000150:complications* / Q000628:therapy; D012044:Regression Analysis; D057185:Sedentary Behavior