title: Current perspective in tuberculosis vaccine development for high TB endemic regions.
abstract: Tuberculosis (TB) continues to be a global epidemic, despite of the availability of Bacillus Calmette Guerin (BCG) vaccine for more than six decades. In an effort to eradicate TB, vaccinologist around the world have made considerable efforts to develop improved vaccine candidates, based on the understanding of BCG failure in developing world and immune response thought to be protective against TB. The present review represents a current perspective on TB vaccination research, including additional research strategies needed for increasing the efficacy of BCG, and for the development of new effective vaccines for high TB endemic regions.
authors.affiliation: Biochemistry Research Laboratory, Central India Institute of Medical Sciences, 88/2 Bajaj Nagar, Nagpur 440 010, India.
authors.forename: Aliabbas A
authors.initials: AA
authors.lastname: Husain
authors.affiliation: Biochemistry Research Laboratory, Central India Institute of Medical Sciences, 88/2 Bajaj Nagar, Nagpur 440 010, India.
authors.forename: Hatim F
authors.initials: HF
authors.lastname: Daginawala
authors.affiliation: Biochemistry Research Laboratory, Central India Institute of Medical Sciences, 88/2 Bajaj Nagar, Nagpur 440 010, India.
authors.forename: Lokendra
authors.initials: L
authors.lastname: Singh
authors.affiliation: Biochemistry Research Laboratory, Central India Institute of Medical Sciences, 88/2 Bajaj Nagar, Nagpur 440 010, India. Electronic address: raj_ciims@rediffmail.com.
authors.forename: Rajpal S
authors.initials: RS
authors.lastname: Kashyap
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000009:adverse effects / Q000627:therapeutic use*; D055808:Drug Discovery / Q000379:methods*; D019353:Endemic Diseases; D006801:Humans; D007194:India / Q000453:epidemiology; D011379:Prognosis; D014376:Tuberculosis / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D032581:Tuberculosis Vaccines / Q000009:adverse effects / Q000627:therapeutic use*; D014611:Vaccination
chemical_list: D001500:BCG Vaccine; D032581:Tuberculosis Vaccines
keywords: BCG; Biomarkers; Endemic regions; T cell; Vaccine