title: MicroRNA-544 inhibits glioma proliferation, invasion and migration but induces cell apoptosis by targeting PARK7.
abstract: Glioma is a common type of primary brain tumor. The survival rate in people with malignant gliomas is extremely low associated with the lack of effective treatment. Here, we firstly observed that miR-544 expression is downregulated in glioma tissues and its overexpression in glioma cell line dramatically reduces cell proliferation, migration and invasion. In addition, we found that the tumor growth in nude mouse was as well inhibited by miR-544 overexpressed in glioma cell. Our further investigation showed that the inhibitor role of miR-544 in tumor development was related to the downregulated expression of Park7 gene which has been demonstrated as a functional downstream target of miR-544. Thus, our discovery suggested that miR-544 might used as a therapeutic reagent for the treatment of glioma in the future.
authors.affiliation: The Second Xiangya Hospital of Central South University Changsha 410011, Hunan, China.
authors.forename: Shiguang
authors.initials: S
authors.lastname: Jin
authors.affiliation: The Second Xiangya Hospital of Central South University Changsha 410011, Hunan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Northern Jiangsu People's Hospital Yangzhou, Jiangsu 225001, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Li
authors.affiliation: Northern Jiangsu People's Hospital Yangzhou, Jiangsu 225001, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Fang
authors.affiliation: Northern Jiangsu People's Hospital Yangzhou, Jiangsu 225001, China.
authors.forename: Huijing
authors.initials: H
authors.lastname: Han
authors.affiliation: Northern Jiangsu People's Hospital Yangzhou, Jiangsu 225001, China.
authors.forename: Daxin
authors.initials: D
authors.lastname: Wang
keywords: PARK7; cell growth; glioma; invasion; microRNA; migration