title: Mass Measurement of Single Intact Nanoparticles in a Cylindrical Ion Trap.
abstract: Accurate nanoparticle mass characterization is a challenging task, especially at a single particle level. To solve this problem, a strategy for the mass measurement of single intact nanoparticle was proposed. A microscopy-based ion trap mass spectrometer was built up. To improve the detection sensitivity, a cylindrical ion trap with transparent conductive end-caps was used to increase the transmission of scattered light, and a vacuum ultraviolet lamp was used to increase the charge state of the isolated nanoparticle. By detecting the scattered light of the isolated nanoparticle, a series of secular frequencies were obtained, from which the corresponding mass-to-charge ratio of the nanoparticle was calculated. Finally, a Labview program was used to help deduce the charge state and absolute mass of the individual nanoparticle. Masses of gold nanoparticles with different sizes were accurately examined, which are (5.08 ± 0.44) × 10(7) Da for 20 nm, (3.55 ± 0.34) × 10(8) Da for 40 nm, and (1.22 ± 0.14) × 10(9) Da for 60 nm, respectively. The mass of MOFs with irregular shapes was also determined, which is (6.48 ± 1.08) × 10(9) Da. This method can provide the mass information on nanomaterials, thus opens up new possibility of characterizing nanoparticles at the single particle level.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Optical Engineering, Beijing Institute of Technology , Beijing 100081, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhu
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Caiqiao
authors.initials: C
authors.lastname: Xiong
authors.affiliation: Department of Optical Engineering, Beijing Institute of Technology , Beijing 100081, China.
authors.forename: Yurong
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Institute of Atomic and Molecular Sciences, Academia Sinica , Taipei 106, Taiwan.
authors.forename: Huan-Cheng
authors.initials: HC
authors.lastname: Chang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry Chinese Academy of Sciences , Beijing 100190, China.|National Center for Mass Spectrometry in Beijing , Beijing 100190, China.
authors.forename: Zongxiu
authors.initials: Z
authors.lastname: Nie