title: Applications of PET/CT in Pediatric Patients with Fever of Unknown Origin.
abstract: Fever of unknown origin (FUO) is a challenging problem. In children, FUO is critical, as it may hide a life threatening disease. One of the main difficulties in managing patients with FUO is the absence of a universal diagnostic approach. There are many impending causes for FUO. Most cases are attributable to atypical presentations of common diseases. The key to establishing the diagnosis is through comprehensive clinical data and targeted investigations. Despite all efforts, the underlying cause remains undiagnosed in many cases. PET/CT is a powerful modality that has been proven to be useful in many common causes that could emerge as FUO. This article reviews the utility of PET/CT imaging in children with FUO.
authors.affiliation: Department of Radiology, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Radiology, National Liver Institute, 1 El-Gizera El-Wousta Street, Zamalek, 11211, Cairo, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Houseni
authors.affiliation: Department of Radiology, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Wichana
authors.initials: W
authors.lastname: Chamroonrat
authors.affiliation: Department of Radiology, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Sabah
authors.initials: S
authors.lastname: Servaes
authors.affiliation: Department of Radiology, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Abass
authors.initials: A
authors.lastname: Alavi
authors.affiliation: Department of Radiology, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address: zhuang@email.chop.edu.
authors.forename: Hongming
authors.initials: H
authors.lastname: Zhuang
keywords: Fever of unknown origin; Infections; Inflammation; Oncology; PET/CT