title: Continuous versus intermittent docetaxel for metastatic castration resistant prostate cancer.
abstract: Docetaxel (DTX) is a standard chemotherapeutic agent for metastatic castration resistant prostate cancer (mCRPC). However, given a number of toxicities associated with DTX, considerable debate exists regarding the optimal number of DTX cycles to be administered in this setting. In clinic, it is a usual practice to continue DTX until toxicities or disease progression precludes its administration. Therefore, we undertook a comprehensive review of the literature on intermittent versus continuous chemotherapy administration in this setting. Although there is no head-to-head comparison of these two approaches, our review discovered many studies which show that intermittent approach is a very feasible and attractive option with lower toxicities and better quality of life. Because of the availability of many newer agents that can be used post-docetaxel, stopping DTX early seems to be more appropriate with introduction of docetaxel or newer agents upon progression. This review summarizes the data from available studies regarding the feasibility and controversies of intermittent docetaxel in prostate cancer.
authors.affiliation: Department of Hemato-Oncology, Nobel Hospital, Sinamangal, Kathmandu, Nepal. Electronic address: bg.bishalgyawali@gmail.com.
authors.forename: Bishal
authors.initials: B
authors.lastname: Gyawali
authors.affiliation: Goulburn Valley Health, Victoria, Australia.
authors.forename: Sahadudheen
authors.initials: S
authors.lastname: Koomulli-Parambil
authors.affiliation: School of Clinical Sciences & Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia. Electronic address: mahesh.iddawela@monash.edu.au.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Iddawela
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018450:Disease Progression; D000077143:Docetaxel; D006801:Humans; D008297:Male; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy* / Q000473:pathology; D011788:Quality of Life; D043823:Taxoids / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel
keywords: Castration resistant; Continuous; Docetaxel; Intermittent; Prostate cancer