title: Therapeutic options following pneumonectomy in non-small cell lung cancer.
abstract: Pneumonectomy can be considered the most appropriate treatment for lung cancer that cannot be removed by lesser resection on.
  
  
  
  Therapeutic options following pneumonectomy may be required at least in 3 different scenarios: 1) an early approach due to acute surgical complications 2) a late approach due to chronic surgical complications 3) an integrated radio-chemotherapeutic adjuvant approach for advanced stages. In this review we focused on these three settings with particular emphasis to surgical approach as well as to alternative options. Expert commentary: Pneumonectomy itself does not preclude postoperative additional treatments, if needed, to maximize oncological results and to manage potential short or long term complications. However, as pneumonectomy puts a significant physiological stress on the respiratory and circulatory systems, the benefits and risks of pneumonectomy should be compared with those of alternative, non-resectional treatment modalities.
authors.affiliation: a Department of Thoracic Surgery , University of Milan , Milan , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Petrella
authors.affiliation: a Department of Thoracic Surgery , University of Milan , Milan , Italy.|b Department of Oncology and Hematology/Oncology - DIPO , University of Milan , Milan , Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Spaggiari
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D011013:Pneumonectomy / Q000009:adverse effects*; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*
keywords: Pneumonectomy; adjuvant chemotherapy; radiotherapy; single-lung surgery; thermal ablation