title: Diagnosis of perinuclear anti-neutrophil cytoplasmic antibody-associated microscopic polyangiitis in silicotics: case report.
abstract: BACKGROUND
  An association between silica exposure and autoimmune diseases including rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, and anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis has been made.
  
  
  METHODS
  A 56-year-old male presented with silicosis and had an occupational history of precious metal processing for 30 years and a 30 pack-year smoking history. The patient was diagnosed with pneumoconiosis and received compensation. No other complications were reported for pneumoconiosis. The patient suddenly presented with a non-specific headache for several days and microscopic hematuria was identified upon examination in the outpatient clinic. Following several weeks, the patient presented with aggravated dyspnea and hemoptysis, and his Modification of Diet in Renal Disease estimated glomerular filtration rate indicated acute kidney injury. Diagnostic analysis revealed perinuclear ANCA-associated microscopic polyangiitis (p-ANCA-associated MPA).
  
  
  CONCLUSIONS
  Exposure to silica dust was likely one of the cause of p-ANCA-associated MPA. Possible pathogenic mechanisms of autoimmune diseases in silicotics and emphasis of the necessity for early diagnosis are discussed.
authors.affiliation: Department of Occupational and Environmental Medicine Seoul St. Mary`s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-Daero Seocho-gu, Seoul, 137-701 Republic of Korea ; Center for Occupational and Environmental Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, 222 Banpo-Daero Seocho-gu, Seoul, 137-701 Republic of Korea.
authors.forename: Ji-Won
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Occupational and Environmental Medicine Seoul St. Mary`s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-Daero Seocho-gu, Seoul, 137-701 Republic of Korea ; Center for Occupational and Environmental Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, 222 Banpo-Daero Seocho-gu, Seoul, 137-701 Republic of Korea.
authors.forename: Jun-Pyo
authors.initials: JP
authors.lastname: Myong
authors.affiliation: Department of Hospital Pathology, Seoul St. Mary`s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Yeong-Jin
authors.initials: YJ
authors.lastname: Choi
authors.affiliation: Department of Occupational and Environmental Medicine Seoul St. Mary`s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-Daero Seocho-gu, Seoul, 137-701 Republic of Korea ; Center for Occupational and Environmental Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, 222 Banpo-Daero Seocho-gu, Seoul, 137-701 Republic of Korea.
authors.forename: Seyoung
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Occupational and Environmental Medicine Seoul St. Mary`s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-Daero Seocho-gu, Seoul, 137-701 Republic of Korea ; Center for Occupational and Environmental Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, 222 Banpo-Daero Seocho-gu, Seoul, 137-701 Republic of Korea.
authors.forename: Bum Seak
authors.initials: BS
authors.lastname: Jo
authors.affiliation: Department of Occupational and Environmental Medicine Seoul St. Mary`s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-Daero Seocho-gu, Seoul, 137-701 Republic of Korea ; Center for Occupational and Environmental Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, 222 Banpo-Daero Seocho-gu, Seoul, 137-701 Republic of Korea.
authors.forename: Jung-Wan
authors.initials: JW
authors.lastname: Koo
keywords: Autoimmune disease; Occupational exposure; Silicon dioxide; Silicosis