title: Collapsing glomerulopathy with rare associated coxsackie virus infection: A case report.
abstract: A 38-year-old Chinese man was admitted to the Second Xiangya Hospital of the Central South University (Changsha, China) with heavy proteinuria and rapidly progressing renal failure with nephrotic syndrome. An initial renal biopsy identified collapsing glomerulopathy (CG) with characteristic segmental collapse of the glomerular tuft and marked hypertrophy and hyperplasia of the visceral epithelial cells. A second renal biopsy showed dilation of glomerular capillary loops as a result of effective treatment with rapamycin and anti-viral therapy. Serology for the coxsackie virus antibody was positive when the collapsing lesion was present, and became negative following treatment, which indicated a strong association between the development of CG and coxsackie virus infection. To the best of our knowledge, this is the first case report of CG associated with coxsackie virus infection.
authors.affiliation: Department of Nephrology, Kidney Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors.forename: Xuejing
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Nephrology, Kidney Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Nephrology, Kidney Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Yuan
authors.affiliation: Department of Nephrology, Kidney Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors.forename: Xiangqing
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Nephrology, Kidney Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Dong
authors.affiliation: Department of Nephrology, Kidney Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors.forename: Fuyou
authors.initials: F
authors.lastname: Liu
keywords: collapsing glomerulopathy; coxsackie virus; renal biopsy