title: A New IVH Scoring System Based on Laterality Enhances Prediction of Neurodevelopmental Outcomes at 3 Years Age in Premature Infants.
abstract: ObjectiveTo compare the new intraventricular hemorrhage (IVH) Abdi score to the Papile grading system of IVH for prediction of composite outcome of death or neurodevelopmental impairment (NDI).MethodsIn a cohort study, all preterm infants with IVH who were born ≤1,250 g and/or ≤ 28 weeks of gestation at birth were prospectively followed up in our neonatal follow-up clinic. All cranial ultrasounds of the included infants were reviewed by neuroradiologists who were blinded to the clinical data and neurodevelopmental outcomes. Cranial ultrasounds were graded according to the Papile scoring system and by calculation of the Abdi score.ResultsA total of 183 preterm infants met inclusion and exclusion criteria. Of these, 80 (44%) had the composite primary outcome of death or NDI (51 died, 29 survived with NDI). The area under receiver operating characteristic curve for predicting death or NDI was 0.87 (95% confidence interval [CI]: 0.81-0.93) for Abdi score and 0.85 (95% CI: 0.79-0.91) for Papile grading (p= 0.04). Abdi scores had higher specificity than Papile grade II at Abdi score 5 (63.9 vs. 39.2%;p< 0.001) and Abdi score 6 (73.2 vs. 39.2%;p< 0.001).ConclusionAbdi scores seem to be more specific than Papile grading system in predicting death or NDI by 3 years' corrected age.
authors.affiliation: Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Mountasser
authors.initials: M
authors.lastname: Al-Mouqdad
authors.affiliation: Department of Pediatrics, King Abdulaziz Hospital, Ministry of National Guard, Al-Ahsa, Saudi Arabia.
authors.forename: Sameer
authors.initials: S
authors.lastname: Al-Abdi
authors.affiliation: Alberta Health Services, Alberta, Canada.
authors.forename: James N
authors.initials: JN
authors.lastname: Scott
authors.affiliation: Alberta Health Services, Alberta, Canada.
authors.forename: Alison
authors.initials: A
authors.lastname: Hurley
authors.affiliation: Alberta Health Services, Alberta, Canada.
authors.forename: Selphee
authors.initials: S
authors.lastname: Tang
authors.affiliation: Alberta Health Services, Alberta, Canada.
authors.forename: Dianne
authors.initials: D
authors.lastname: Creighton
authors.affiliation: Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Khorshid
authors.initials: K
authors.lastname: Mohammad
authors.affiliation: Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Majeeda
authors.initials: M
authors.lastname: Kamaluddeen
authors.affiliation: Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Abhay
authors.initials: A
authors.lastname: Lodha
mesh_terms: D000293:Adolescent; D000328:Adult; D000074042:Cerebral Intraventricular Hemorrhage / Q000000981:diagnostic imaging* / Q000453:epidemiology; D002675:Child, Preschool; D015331:Cohort Studies; D004453:Echoencephalography; D005260:Female; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D008297:Male; D009026:Mortality; D065886:Neurodevelopmental Disorders / Q000453:epidemiology*; D011247:Pregnancy; D011446:Prospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D055815:Young Adult