title: Brazilian Green Propolis Improves Antioxidant Function in Patients with Type 2 Diabetes Mellitus.
abstract: Propolis contains a variety of bioactive components and possesses many biological properties. This study was designed to evaluate potential effects of Brazilian green propolis on glucose metabolism and antioxidant function in patients with type 2 diabetes mellitus (T2DM). In the 18-week randomized controlled study, enrolled patients with T2DM were randomly assigned to Brazilian green propolis group (900 mg/day) (n = 32) and control group (n = 33). At the end of the study, no significant difference was found in serum glucose, glycosylated hemoglobin, insulin, aldose reductase or adiponectin between the two groups. However, serum GSH and total polyphenols were significantly increased, and serum carbonyls and lactate dehydrogenase activity were significantly reduced in the Brazilian green propolis group. Serum TNF-α was significantly decreased, whereas serum IL-1β and IL-6 were significantly increased in the Brazilian green propolis group. It is concluded that Brazilian green propolis is effective in improving antioxidant function in T2DM patients.
authors.affiliation: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China. zlt_medic@126.com.|Department of Nutrition, Pingjin Hospital, Tianjin 300162, China. zlt_medic@126.com.
authors.forename: Liting
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China. pulingling@163.com.
authors.forename: Lingling
authors.initials: L
authors.lastname: Pu
authors.affiliation: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China. wjy55333@126.com.
authors.forename: Jingyu
authors.initials: J
authors.lastname: Wei
authors.affiliation: Department of Endocrinology, Pingjin Hospital, Tianjin 300162, China. lijingh1020@163.com.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Health Education, Tianjin Institute of Health Education, Tianjin 300011, China. wupp17@163.com.
authors.forename: Jianquan
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China. xinzhonghaojk@163.com.
authors.forename: Zhonghao
authors.initials: Z
authors.lastname: Xin
authors.affiliation: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China. gwn2004bo@126.com.
authors.forename: Weina
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China. guocjtj@126.com.
authors.forename: Changjiang
authors.initials: C
authors.lastname: Guo
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001938:Brazil; D016207:Cytokines / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D005260:Female; D005978:Glutathione / Q000097:blood; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D059808:Polyphenols / Q000097:blood; D011429:Propolis / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D016207:Cytokines; D005978:Glutathione; D006442:Glycated Hemoglobin; D007328:Insulin; D059808:Polyphenols; D011429:Propolis; C499918:ADIPOQ protein, human
keywords: Brazilian green propolis; antioxidant function; type 2 diabetes mellitus