title: Inhibition of autophagy with clarithromycin: a new strategy to enhance sensitivity of CML stem cells to tyrosine kinase inhibitors.
abstract: Autophagy inhibition has been shown to sensitize tumor cells to cell death induced by tyrosine kinase inhibitors (TKIs). The remarkable responses obtained in seven patients with the combination of clarithromycin and TKIs support the hypothesis that the inhibition of autophagy may make chronic myeloid leukemia cells sensitive to killing by TKIs.
authors.affiliation: Hematology Division, IRCCS Azienda Ospedaliera Universitaria San Martino, IST Istituto Nazionale per la Ricerca sul Cancro , Genova, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Carella
authors.affiliation: Hematology Division, IRCCS Azienda Ospedaliera Universitaria San Martino, IST Istituto Nazionale per la Ricerca sul Cancro , Genova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Beltrami
authors.affiliation: Hematology Division, IRCCS Azienda Ospedaliera Universitaria San Martino, IST Istituto Nazionale per la Ricerca sul Cancro , Genova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Catania
authors.affiliation: Hematology Division, IRCCS Azienda Ospedaliera Universitaria San Martino, IST Istituto Nazionale per la Ricerca sul Cancro , Genova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pica
authors.affiliation: Hematology Division, IRCCS Azienda Ospedaliera Universitaria San Martino, IST Istituto Nazionale per la Ricerca sul Cancro , Genova, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Ghiggi
authors.affiliation: Hematology Division, IRCCS Azienda Ospedaliera Universitaria San Martino, IST Istituto Nazionale per la Ricerca sul Cancro , Genova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Garuti
authors.affiliation: Hematology Division, IRCCS Azienda Ospedaliera Universitaria San Martino, IST Istituto Nazionale per la Ricerca sul Cancro , Genova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Carella
keywords: autophagy; chronic myeloid leukemia; clarithromycin; tyrosine kinase inhibitors