title: Hemocompatibility and oxygenation performance of polysulfone membranes grafted with polyethylene glycol and heparin by plasma-induced surface modification.
abstract: Polyethylene glycol (PEG) and heparin (Hep) were grafted onto polysulfone (PSF) membrane by plasma-induced surface modification to prepare PSF-PEG-Hep membranes used for artificial lung. The effects of plasma treatment parameters, including power, gas type, gas flow rate, and treatment time, were investigated, and different PEG chains were bonded covalently onto the surface in the postplasma grafting process. Membrane surfaces were characterized by water contact angle, PEG grafting degree, attenuated total reflectance-Fourier transform infrared spectroscopy, ultraviolet-visible spectrophotometry, X-ray photoelectron spectroscopy, critical water permeability pressure, and scanning electron microscopy. Protein adsorption, platelet adhesion, and coagulation tests showed significant improvement in the hemocompatibility of PSF-PEG-Hep membranes compared to pristine PSF membrane. Gas exchange tests through PSF-PEG6000-Hep membrane showed that when the flow rate of porcine blood reached 5.0 L/min, the permeation fluxes of O2and CO2reached 192.6 and 166.9 mL/min, respectively, which were close to the gas exchange capacity of a commercial membrane oxygenator. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1737-1746, 2017.
authors.affiliation: Department of Chemical Engineering, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, People's Republic of China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Chemical Engineering, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, People's Republic of China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
authors.forename: Wenling
authors.initials: W
authors.lastname: Fan
authors.affiliation: Medical School, Nanjing University, Nanjing, People's Republic of China.
authors.forename: Wenkui
authors.initials: W
authors.lastname: Yu
authors.affiliation: Department of Chemical Engineering, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, People's Republic of China.
authors.forename: Zhibing
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Chemical Engineering, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, People's Republic of China.
authors.forename: Chun
authors.initials: C
authors.lastname: Mao
mesh_terms: D001792:Blood Platelets / Q000378:metabolism*; D015199:Extracorporeal Membrane Oxygenation; D006493:Heparin / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D058626:Plasma Gases / Q000737:chemistry*; D010973:Platelet Adhesiveness; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013450:Sulfones / Q000737:chemistry*
chemical_list: D008567:Membranes, Artificial; D058626:Plasma Gases; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; D011092:Polyethylene Glycols; D006493:Heparin
keywords: artificial lung; gas exchange rate; hemocompatibility; plasma modification; polysulfone-polyethylene glycol-heparin membranes