title: Method for Studying the Myocardial Blood Flow Reserve by Load Dynamic Single-Photon Emission Computed Tomography.
abstract: We developed a method for collection and processing of scintigraphic data to estimate myocardial reserve in a gamma-chamber with cadmium-zinc-telluride detectors. Dynamic single-photon emission computed tomography of the heart with (99m)Tc-Technetril was performed in 16 coronary heart disease patients at rest and during pharmacological load. During data processing, regions of interest from the cavity and the myocardium of the left ventricle were formed and activity-time curves were constructed. The index of myocardial blood fl ow reserve was calculated as the difference between two ratios of the mean gamma-count from the myocardial area to the area under the left ventricle cavity curve (peak) during load and at rest. The mean indices of myocardial reserve in healthy volunteers and patients with coronary artery atherosclerosis were 1.86 (1.59; 2.20) and 1.39 (1.12; 1.69), respectively. The development of the method for studying myocardial reserve by single-photon emission computed tomography is an urgent problem and requires further investigations.
authors.affiliation: Laboratory for Radionuclide Research Methods, Research Institute of Cardiology, Tomsk, Russian Federation. mochula.andrew@gmail.com.
authors.forename: A V
authors.initials: AV
authors.lastname: Mochula
authors.affiliation: Laboratory for Radionuclide Research Methods, Research Institute of Cardiology, Tomsk, Russian Federation.|Laboratory No. 31, Physical-Technical Institute, National Research Tomsk Polytechnic University, Tomsk, Russia.
authors.forename: K V
authors.initials: KV
authors.lastname: Zavadovsky
authors.affiliation: Laboratory for Radionuclide Research Methods, Research Institute of Cardiology, Tomsk, Russian Federation.|Laboratory No. 31, Physical-Technical Institute, National Research Tomsk Polytechnic University, Tomsk, Russia.
authors.forename: Yu B
authors.initials: YB
authors.lastname: Lishmanov
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003331:Coronary Vessels / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D012372:ROC Curve; D012039:Regional Blood Flow; D015899:Tomography, Emission-Computed, Single-Photon
keywords: coronary heart disease; myocardial reserve; positron emission tomography; single-photon emission computed tomography