title: Prenatally Diagnosed Aggressive Intracranial Immature Teratoma-Clinicopathological Correlation.
abstract: OBJECTIVE
  To describe clinicopathological correlation of congenital intracranial immature teratoma.
  
  
  METHODS
  A retrospective case analysis from a tertiary medical center.
  
  
  RESULTS
  We report a case of an intracranial immature teratoma detected prenatally at 35 weeks of gestation. The tumor showed rapid growth, causing acute hydrocephalus requiring subsequent ventriculoperitoneal shunting. Resective surgery was performed within 2 weeks after birth. The infant died at day of life 29. Histological examination revealed an immature teratoma, with high MIB1/Ki-67 proliferation index.
  
  
  CONCLUSIONS
  Intracranial immature teratoma with high MIB1/Ki-67 proliferation index may serve as an independent poor prognostic factor.
authors.affiliation: a Neurology, Montefiore Hospital and Medical Center , Bronx , NY , USA.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nariai
authors.affiliation: b Pediatrics, Albany Medical Center , Albany , NY , USA.
authors.forename: Dana E
authors.initials: DE
authors.lastname: Price
authors.affiliation: c Neurosurgery, Montefiore Hospital and Medical Center , Bronx , NY , USA.
authors.forename: Ajit
authors.initials: A
authors.lastname: Jada
authors.affiliation: b Pediatrics, Albany Medical Center , Albany , NY , USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: Weintraub
authors.affiliation: d Pathology, Montefiore Hospital and Medical Center , Bronx , NY , USA.
authors.forename: Karen M
authors.initials: KM
authors.lastname: Weidenheim
authors.affiliation: a Neurology, Montefiore Hospital and Medical Center , Bronx , NY , USA.|e Radiology, Montefiore Hospital and Medical Center , Bronx , NY , USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Gomes
authors.affiliation: f Pediatrics, Montefiore Hospital and Medical Center , Bronx , NY , USA.
authors.forename: Adam S
authors.initials: AS
authors.lastname: Levy
authors.affiliation: c Neurosurgery, Montefiore Hospital and Medical Center , Bronx , NY , USA.
authors.forename: Rick
authors.initials: R
authors.lastname: Abbott
authors.affiliation: a Neurology, Montefiore Hospital and Medical Center , Bronx , NY , USA.
authors.forename: Fatema
authors.initials: F
authors.lastname: Malbari
mesh_terms: D001932:Brain Neoplasms / Q000151:congenital* / Q000175:diagnosis* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013724:Teratoma / Q000151:congenital* / Q000175:diagnosis* / Q000473:pathology
keywords: Immature teratoma; MIB1/Ki-67 proliferation index; congenital brain tumor; prenatal diagnosis