title: Evaluations of treatment efficacy of depression from perspective of both patients' symptoms and general sense of mental health and wellbeing: A large scale, multi-centered, longitudinal study in China.
abstract: Relying on the absence, presence of level of symptomatology may not provide an adequate indication of the effects of treatment for depression, nor sufficient information for the development of treatment plans that meet patients' needs. Using a prospective, multi-centered, and observational design, the present study surveyed a large sample of outpatients with depression in China (n=9855). The 17-item Hamilton Rating Scale for Depression (HRSD-17) and the Remission Evaluation and Mood Inventory Tool (REMIT) were administered at baseline, two weeks later and 4 weeks, to assess patients' self-reported symptoms and general sense of mental health and wellbeing. Of 9855 outpatients, 91.3% were diagnosed as experiencing moderate to severe depression. The patients reported significant improvement over time on both depressive symptoms and general sense after 4-week treatment. The effect sizes of change in general sense were lower than those in symptoms at both two week and four week follow-up. Treatment effects on both general sense and depressive symptomatology were associated with demographic and clinical factors. The findings indicate that a focus on both general sense of mental health and wellbeing in addition to depressive symptomatology will provide clinicians, researchers and patients themselves with a broader perspective of the status of patients.
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
authors.forename: Qingzhi
authors.initials: Q
authors.lastname: Zeng
authors.affiliation: School of Public Health and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne 3004, Australia.
authors.forename: Wei Chun
authors.initials: WC
authors.lastname: Wang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
authors.forename: Yiru
authors.initials: Y
authors.lastname: Fang
authors.affiliation: School of Psychology, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Mellor
authors.affiliation: School of Psychology, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia.
authors.forename: Marita
authors.initials: M
authors.lastname: Mccabe
authors.affiliation: School of Psychology, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia.
authors.forename: Linda
authors.initials: L
authors.lastname: Byrne
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
authors.forename: Sai
authors.initials: S
authors.lastname: Zuo
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China; Shanghai Key Laboratory of Psychotic Disorders, 600 Wan Ping Nan Road, Shanghai 200030, China. Electronic address: hyyyyb@gmail.com.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D003866:Depressive Disorder / Q000453:epidemiology / Q000628:therapy*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008603:Mental Health / Q000706:statistics & numerical data*; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D063868:Patient Outcome Assessment
keywords: Hamilton Rating Scale for Depression (HRSD-17); Mental health; Observational design, Remission Evaluation and Mood Inventory Tool (REMIT); Symptom; Wellbeing