title: Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed.
abstract: Two-pore channels (TPCs) are intracellular Ca(2+)-permeable ion channels that are expressed on acidic Ca(2+) stores. They are co-regulated by voltage and Ca(2+) in plant vacuoles and by the second messenger NAADP in animal endo-lysosomes. Two new studies of plant TPC structures reveal essential features of their architecture and provide mechanistic insight into their workings.
authors.affiliation: Department of Cell and Developmental Biology, University College London, London, UK. Electronic address: patel.s@ucl.ac.uk.
authors.forename: Sandip
authors.initials: S
authors.lastname: Patel
authors.affiliation: Department of Cell and Developmental Biology, University College London, London, UK.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Penny
authors.affiliation: Department of Pharmacology, University of Cambridge, Cambridge, UK.
authors.forename: Taufiq
authors.initials: T
authors.lastname: Rahman
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D020013:Calcium Signaling; D018360:Crystallography, X-Ray; D011992:Endosomes / Q000378:metabolism; D015870:Gene Expression; D015640:Ion Channel Gating; D008247:Lysosomes / Q000378:metabolism; D009249:NADP / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D000072756:Protein Conformation, alpha-Helical; D054730:Protein Interaction Domains and Motifs; D014617:Vacuoles / Q000737:chemistry / Q000378:metabolism*; D000097903:Two-Pore Channels
chemical_list: D029681:Arabidopsis Proteins; D002118:Calcium; D015220:Calcium Channels; D009249:NADP; C498240:TPC1 protein, Arabidopsis; D000097903:Two-Pore Channels; C024376:NAADP