title: Heart Rate Recovery Is Impaired in Patients with Inflammatory Bowel Diseases.
abstract: OBJECTIVE
  In this study we aimed to investigate heart rate recovery (HRR) in patients with inflammatory bowel disease (IBD).
  
  
  METHODS
  A total of 40 patients with IBD and 30 healthy controls were included in this study. A treadmill stress test was performed in all the patients to calculate the HRR index based on the age-specific maximum heart rate. The HRR indices were calculated as follows: HRR1, 2, 3, 4, 5 = heart rate at peak exercise - heart rate at 1, 2, 3, 4, and 5 min. The independent samples t test was used to compare HRR indices between the patient and control groups. The Pearson correlation coefficient was used to examine the association between the duration of IBD and the HRR indices. Multivariate regression analysis was carried out to identify predictors of impaired HRR in patients with IBD.
  
  
  RESULTS
  HRR indices at various time intervals were significantly lower in the patients with IBD than in the controls: HRR1 (1.18 ± 8 vs. 31 ± 7, p < 0.001), HRR2 (36 ± 12 vs. 51 ± 8, p < 0.001), HRR3 (46 ± 12 vs. 62 ± 11, p < 0.001), HRR4 (54 ± 7 vs. 65 ± 8, p < 0.001), and HRR5 (55 ± 13 vs. 71 ± 15, p < 0.001). Mean duration of IBD was 7.8 ± 3.6 years. In addition, there was a significant negative correlation between disease duration and HRR at the first minute (r = -0.704, p < 0.001). Multivariate logistic regression analysis showed that symptom duration (OR: 1.742, 95% CI: 1.148-2.636, p = 0.009) was an independent predictor of impaired HRR in patients with IBD.
  
  
  CONCLUSIONS
  In this study, the data showed that the HRR was impaired in patients with IBDs. Hence, given the prognostic value of the test, patients with IBD should be monitored for future cardiovascular events.
authors.affiliation: Departments of Cardiology and Gastroenterology, Kayseri Education and Research Hospital, Kayseri, Turkey.
authors.forename: Bahadir
authors.initials: B
authors.lastname: Sarli
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Dogan
authors.forename: Orhan
authors.initials: O
authors.lastname: Poyrazoglu
authors.forename: Ahmet Oguz
authors.initials: AO
authors.lastname: Baktir
authors.forename: Abdullah
authors.initials: A
authors.lastname: Eyvaz
authors.forename: Engin
authors.initials: E
authors.lastname: Altinkaya
authors.forename: Ahmet
authors.initials: A
authors.lastname: Tok
authors.forename: Engin
authors.initials: E
authors.lastname: Donudurmaci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ugurlu
authors.forename: Adile
authors.initials: A
authors.lastname: Ortakoyluoglu
authors.forename: Hayrettin
authors.initials: H
authors.lastname: Saglam
authors.forename: Huseyin
authors.initials: H
authors.lastname: Arinc
mesh_terms: D000328:Adult; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000503:physiopathology*; D008297:Male; D013997:Time Factors