title: Multiple anesthetics for a patient with stiff-person syndrome.
abstract: Stiff-person syndrome is a progressive disease of muscle rigidity and spasticity due to a deficiency in the production of γ-aminobutyric acid. Because of the rarity of the condition, little is known about effects of anesthesia on patients with stiff-person syndrome. This report describes the clinical course for a single patient with stiff-person syndrome who received general anesthesia on 3 separate occasions. Her anesthetics included use of both neuromuscular blockade and volatile agents. Unlike several previous reports regarding anesthesia and stiff-person syndrome, the postoperative period for this patient did not require prolonged intubation or result in any residual weakness.
authors.affiliation: University of Pittsburgh, VA Pittsburgh Healthcare System Anesthesia Service, Room 3N221B, University Dr C, Pittsburgh, PA, 15240, USA. Electronic address: cassavaughjm@upmc.edu.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Cassavaugh
authors.affiliation: University of Pittsburgh, VA Pittsburgh Healthcare System Anesthesia Service, Room 3N221B, University Dr C, Pittsburgh, PA, 15240, USA. Electronic address: OravitzTM@anes.upmc.edu.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Oravitz
mesh_terms: D000732:Androstanols; D000768:Anesthesia, General / Q000379:methods*; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D005260:Female; D005283:Fentanyl; D006801:Humans; D008738:Methyl Ethers; D008875:Middle Aged; D019148:Neuromuscular Blockade / Q000379:methods*; D003473:Neuromuscular Nondepolarizing Agents; D015742:Propofol; D000077123:Rocuronium; D000077149:Sevoflurane; D016750:Stiff-Person Syndrome / Q000601:surgery*
chemical_list: D000732:Androstanols; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D003473:Neuromuscular Nondepolarizing Agents; D000077149:Sevoflurane; D005283:Fentanyl; D000077123:Rocuronium; D015742:Propofol
keywords: GABA signaling; Neuromuscular blockade; Stiff-person syndrome