title: The vitamin D receptor gene ApaI polymorphism is associated with increased risk of renal cell carcinoma in Chinese population.
abstract: Molecular epidemiologic studies previously reported that 1,25-dihydroxy vitamin D3 (1,25(OH)2 D3) appears to influence cancer risk. It exerts its activity through the intracellular vitamin D receptor (VDR), which regulates the transcription of genes. This study aimed to investigate the genetic association of VDR polymorphisms with renal cell carcinoma (RCC) risk in the Chinese population. The genotypes of five VDR polymorphisms (TaqI, BsmI, Cdx-2, ApaI, and FokI) were studied using polymerase chain reaction in 302 RCC patients and 302 healthy controls. ApaI variant AA and AC genotypes were found to be associated with a significantly increased risk of RCC compared with the CC genotype (OR = 2.60, 95% CI = 1.39-4.85 for AA vs. CC, and OR = 1.52, 95% CI = 1.08-2.13 for AC vs. CC). The AA genotype was also associated with a higher Fuhrman grade (OR = 2.87, 95% CI = 1.15-7.16 for AA vs. CC). No significant difference was found between the other four VDR polymorphisms and RCC risk. Our study suggests that VDR ApaI genotypes may be involved in the increased risk and progression of RCC in the Chinese Han population.
authors.affiliation: Department of Urology, the First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Chunming
authors.initials: C
authors.lastname: Yang
authors.affiliation: Blood Collecting Centers, the First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Molecular Oncology Department of Cancer Research Institution, the First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Molecular Oncology Department of Cancer Research Institution, the First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.affiliation: Molecular Oncology Department of Cancer Research Institution, the First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Chengguang
authors.initials: C
authors.lastname: Sui
authors.affiliation: Molecular Oncology Department of Cancer Research Institution, the First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Youhong
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Molecular Oncology Department of Cancer Research Institution, the First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Fandong
authors.initials: F
authors.lastname: Meng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D012306:Risk; D014807:Vitamin D / Q000378:metabolism
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D