title: The probability of speciation on an interaction network with unequal substitution rates.
abstract: Speciation is characterized by the development of reproductive isolating barriers between diverging groups. A seminal paper of a mathematical model of speciation was published by Orr (1995), extended by Livingstone et al. (2012) to incorporate interaction networks. Here, we further develop the model to take into account the possibility of different substitution rates for network nodes of different connectivity. Mathematically, this amounts to sampling nodes from an undirected graph where the inclusion probability for a given node depends on its degree (number of connecting edges). We establish formulas for the rate of speciation and identify a crucial parameter that is a measure of the deviation from simple random sampling.
authors.affiliation: Department of Mathematics, Trinity University, United States; School of Engineering, Jönköping University, Sweden. Electronic address: polofsso@trinity.edu.
authors.forename: Peter
authors.initials: P
authors.lastname: Olofsson
authors.affiliation: Department of Biology, Trinity University, United States.
authors.forename: Kevin
authors.initials: K
authors.lastname: Livingstone
authors.affiliation: Department of Biology, Trinity University, United States.
authors.forename: Joshua
authors.initials: J
authors.lastname: Humphreys
authors.affiliation: Department of Mathematics, Trinity University, United States.
authors.forename: Douglas
authors.initials: D
authors.lastname: Steinman
mesh_terms: D049810:Genetic Speciation; D008957:Models, Genetic; D054730:Protein Interaction Domains and Motifs
keywords: Bateson-Dobzhansky-Muller interactions; Interaction networks; Reproductive incompatibility; Speciation