title: Iron(II) Halide Promoted Cyclization of Cyclic 2-Enynamides: Stereoselective Synthesis of Halogenated Bicyclic γ-Lactams.
abstract: A simple and mild process was developed for the highly stereoselective synthesis of halogenated bicyclic [4.3.0] and [3.3.0] γ-lactams, possessing four stereocenters, from easily available cyclic 2-enynamides. The reaction required only an inexpensive iron(II) halide under dry air and was tolerant of aryl, heteroaryl, and alkyl groups at the alkyne terminus.
authors.affiliation: Department of Chemistry, National Taiwan Normal University , 88 Ding-Jou Road, Sec. 4, Taipei 11677, Taiwan R.O.C.
authors.forename: Ming-Chang P
authors.initials: MC
authors.lastname: Yeh
authors.affiliation: Department of Chemistry, National Taiwan Normal University , 88 Ding-Jou Road, Sec. 4, Taipei 11677, Taiwan R.O.C.
authors.forename: Yuan-Shin
authors.initials: YS
authors.lastname: Shiue
authors.affiliation: Department of Chemistry, National Taiwan Normal University , 88 Ding-Jou Road, Sec. 4, Taipei 11677, Taiwan R.O.C.
authors.forename: Hsin-Hui
authors.initials: HH
authors.lastname: Lin
authors.affiliation: Department of Chemistry, National Taiwan Normal University , 88 Ding-Jou Road, Sec. 4, Taipei 11677, Taiwan R.O.C.
authors.forename: Tzu-Yu
authors.initials: TY
authors.lastname: Yu
authors.affiliation: Department of Chemistry, National Taiwan Normal University , 88 Ding-Jou Road, Sec. 4, Taipei 11677, Taiwan R.O.C.
authors.forename: Ting-Chia
authors.initials: TC
authors.lastname: Hu
authors.affiliation: Department of Chemistry, National Taiwan Normal University , 88 Ding-Jou Road, Sec. 4, Taipei 11677, Taiwan R.O.C.
authors.forename: Jia-Jyun
authors.initials: JJ
authors.lastname: Hong