title: Erlotinib plus concurrent whole-brain radiation therapy for non-small cell lung cancers patients with multiple brain metastases.
abstract: Sequencing of the epidermal growth factor receptor (EGFR) gene to identify mutations in lung adenocarcinomas is routine in clinical practice. The use of tyrosine kinase inhibitors (TKIs) has transformed the management of patients with brain metastases harboring EGFR mutations, with improved response rates (RR) and survival. We evaluate the role of concurrent TKI therapy and radiotherapy in this group of patients, considering this data in the context of emerging concepts in this advancing field.
authors.affiliation: CRUK Lung Cancer of Excellence, UCL Cancer Institute, Paul O'Gorman Building, University College Hospital, London, UK.
authors.forename: Danny
authors.initials: D
authors.lastname: Ulahannan
authors.affiliation: CRUK Lung Cancer of Excellence, UCL Cancer Institute, Paul O'Gorman Building, University College Hospital, London, UK.
authors.forename: Siow-Ming
authors.initials: SM
authors.lastname: Lee
keywords: Brain metastasis; non-small cell lung cancer (NSCLC); whole brain radiotherapy (WBRT)