title: Subretinal Bone Formation in a Patient with Giant Cell Tumor of the Sphenoid.
abstract: OBJECTIVE
  To report a case of subretinal bone formation after the treatment with denosumab for a giant cell tumor of the sphenoid, which had recurred after surgical resection.
  
  
  METHODS
  The clinical history and fundus findings including imaging, histologic and immunohistochemical features of the primary tumor and subretinal lesion were reviewed.
  
  
  RESULTS
  A 14-year-old boy was evaluated for a suprasellar mass. Resection of the lesion showed giant cell tumor of bone (GCT). An MRI study at the 1-month follow-up appointment showed tumor progression, and denosumab was initiated. Two months after the initial presentation, the patient developed a worsening scotoma of the right eye. Dilated fundus examination showed a yellow-tan-colored subretinal mass temporal to the fovea. The subretinal lesion was removed and showed lamellar bone with associated fibrocellular tissue.
  
  
  CONCLUSIONS
  Denosumab therapy for GCT of the sphenoid may be associated with subretinal bone formation.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, Ga., USA.
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Hwang
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, Ga., USA.
authors.forename: George
authors.initials: G
authors.lastname: Baker Hubbard
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Ga., USA.
authors.forename: Louis
authors.initials: L
authors.lastname: Rapkin
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, Ga., USA; Department of Pathology, Emory University School of Medicine, Atlanta, Ga., USA.
authors.forename: Hans E
authors.initials: HE
authors.lastname: Grossniklaus
keywords: Denosumab; Giant cell tumor of the sphenoid; Subretinal bone formation