title: Functional lung rejuvenation in obese patients after bariatric surgery.
abstract: OBJECTIVE
  To determine the lung age (LA) in obese people before and after bariatric surgery, compare the LA with the chronological age (CA) before and after the peration, and verify whether there was a functional pulmonary rejuvenation after it.
  
  
  METHODS
  A prospective longitudinal study including 43 morbidly obese patients who underwent bariatric surgery. The patients underwent clinical and spirometric evaluation in two stages, before and after the surgery. In both stages, LA, CA and spirometric variables were measured.
  
  
  RESULTS
  A significant improvement in the spirometric variables (FVC; FEV1; and FEV1/FVC ratio) was found after the operation (p≤ 0.0001). Comparing the LA before (50.93±13.36 years) and after the surgery (39.02±12.95 years), there was an important reduction of 11.90±9.12 years (95CI:9.10-14.71; p≤0.0001) in LA after surgery. The difference between LA and CA before surgery was 12.20± 11.71 years (95CI:8.60-15.81) with significant difference (p≤0.0001), and the difference between LA and CA after surgery was -1.95±11.83 years (95CI: -5.59-1.69) with no significant difference (p≤0.28). Regarding LA, we observed a pulmonary aging of 12.20±11.71 years before the surgery and a pulmonary rejuvenation of 11.90±9.12 years after it.
  
  
  CONCLUSIONS
  Morbid obesity is responsible for early damage and functional accelerated pulmonary aging. After the correction of the body weight by surgery, there is a functional pulmonary rejuvenation demonstrated by the normalization of LA in relation to CA.
authors.affiliation: Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors.forename: Saulo Maia Davila
authors.initials: SM
authors.lastname: Melo
authors.affiliation: Universidade Tiradentes, Aracaju, SE, Brazil.
authors.forename: Pedro Alves
authors.initials: PA
authors.lastname: Argentino
authors.affiliation: Universidade Tiradentes, Aracaju, SE, Brazil.
authors.forename: Murilo Matos de Santana
authors.initials: MM
authors.lastname: Oliveira
authors.affiliation: Universidade Tiradentes, Aracaju, SE, Brazil.
authors.forename: Gabriela Nabuco Chaves
authors.initials: GN
authors.lastname: Melo
authors.affiliation: Universidade Tiradentes, Aracaju, SE, Brazil.
authors.forename: Gildo Lima
authors.initials: GL
authors.lastname: Souza Neto
mesh_terms: D000328:Adult; D000367:Age Factors; D000375:Aging / Q000502:physiology; D050110:Bariatric Surgery; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008137:Longitudinal Studies; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000503:physiopathology* / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D012060:Rejuvenation / Q000502:physiology*; D013147:Spirometry; D016896:Treatment Outcome; D014797:Vital Capacity / Q000502:physiology; D015431:Weight Loss / Q000502:physiology