title: Epidemiology of perioperative anaphylaxis.
abstract: Anaphylactic reactions may be either of immune (allergy, usually IgE-mediated, sometimes IgG-mediated) or non-immune origin. The incidence of anaphylactic reactions during anaesthesia varies between countries ranging from 1/1250 to 1/18,600 per procedure. In France, the estimated incidence of allergic reactions is 100.6 [76.2-125.3]/million procedure with a high female predominance (male: 55.4 [42.0-69.0], female: 154.9 [117.2-193.1]). The proportion of IgE-mediated allergic reactions seems to be relatively similar between countries, ranging from 50 to 60%. Substantial geographical variability regarding the different drugs or substances involved is reported. Reactions involving neuromuscular blocking agents are a major cause in several countries but are less frequently reported in the United States or Denmark. Reactions involving antibiotics, dyes or chlorhexidine are reported with a high and sometimes increasing frequency in most series. Reactions to latex are rapidly decreasing as a result of primary and secondary prevention policy. Regional differences are a strong incentive for repeated epidemiological surveys in different countries.
authors.affiliation: Nouvel Hôpital Civil, hôpitaux universitaires de Strasbourg, service d'anesthésie-réanimation chirurgicale, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France. Electronic address: paul-michel.mertes@chru-strasbourg.fr.
authors.forename: Paul Michel
authors.initials: PM
authors.lastname: Mertes
authors.affiliation: Mayo Clinic, Mayo Medical School, Division of Allergic Diseases, 200, First Street SW, Rochester, MN 55905, United States.
authors.forename: Gerald W
authors.initials: GW
authors.lastname: Volcheck
authors.affiliation: Allergy Clinic UA816-GE, Herlev and Gentofte Hospital, Danish Anaesthesia Allergy Centre, Kildegårdsvej 28, DK-2900 Hellerup, Denmark.
authors.forename: Lene H
authors.initials: LH
authors.lastname: Garvey
authors.affiliation: Gunma University Graduate School of Medicine, Department of Anesthesiology, 3-39-22 Showa-machi, 371-8511 Maebashi, Japan.
authors.forename: Tonomori
authors.initials: T
authors.lastname: Takazawa
authors.affiliation: Sir Charles Gairdner Hospital, 6009 Nedlands, Western Australia.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Platt
authors.affiliation: Haukeland university Hospital, Clinical institute 1, Department of Anaesthesiology and Intensive care, Haukeland University, Hospital Jonas Lies v, 5021 Bergen, Norway.
authors.forename: Anne B
authors.initials: AB
authors.lastname: Guttormsen
authors.affiliation: Nouvel Hôpital Civil, hôpitaux universitaires de Strasbourg, service d'anesthésie-réanimation chirurgicale, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Tacquard
mesh_terms: D000707:Anaphylaxis / Q000453:epidemiology* / Q000209:etiology; D000777:Anesthetics / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D007431:Intraoperative Complications / Q000453:epidemiology* / Q000209:etiology
chemical_list: D000777:Anesthetics