title: Pill Burden Influences the Association Between Time-Based Prospective Memory and Antiretroviral Therapy Adherence in Younger But Not Older HIV-Infected Adults.
abstract: Prospective memory (PM) is associated with antiretroviral (ARV) adherence in HIV, but little is known about how pill burden and age might affect this association. One hundred seventeen older (≥50 years) and 82 younger (<50 years) HIV-infected adults were administered a measure of PM in the laboratory and subsequently were monitored for ARV adherence for 30 days using the Medication Event Monitoring System. In the older group, better time-based PM performance was associated with higher likelihood of adherence, irrespective of pill burden. Within the younger sample, time-based PM was positively related to adherence only in participants with lower pill burdens. Younger HIV-infected individuals with higher pill burdens may overcome the normal effects of time-based PM on adherence through compensatory medication-taking strategies, whereas suboptimal use of these strategies by younger HIV-infected individuals with lower pill burdens may heighten their risk of ARV nonadherence secondary to deficits in time-based PM.
authors.forename: David P
authors.initials: DP
authors.lastname: Sheppard
authors.forename: Erica
authors.initials: E
authors.lastname: Weber
authors.forename: Kaitlin B
authors.initials: KB
authors.lastname: Casaletto
authors.forename: Gunes
authors.initials: G
authors.lastname: Avci
authors.forename: Steven Paul
authors.initials: SP
authors.lastname: Woods
mesh_terms: D000328:Adult; D000367:Age Factors; D044966:Anti-Retroviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008569:Memory Disorders / Q000139:chemically induced* / Q000175:diagnosis; D061212:Memory, Episodic; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D020377:Self Efficacy; D013997:Time Factors
chemical_list: D044966:Anti-Retroviral Agents
keywords: HIV; adherence; aging; pill burden; prospective memory