title: Immunohistochemical profile of uterine leiomyomas; a comparison between different subtypes.
abstract: BACKGROUND
  Of all Smooth muscle tumours originating from uterus are leiomyomas are the most common ones. Benign nature and smooth muscle origination of leiomyomas can be easily documented via histological examination. In present study it was tried to examine immunohistochemical profile of leiomyomas with different subtypes.
  
  
  METHODS
  In this cross-sectional study 64 cases of smooth muscle tumors originating from uterus were included in study. As a control group 12 cases of conventional leiomyomas were selected. Then estrogen receptor, progesterone receptor, p53 and ki-67 were assessed. Statistical analysis was conducted using SPSS 16.0.
  
  
  RESULTS
  P 53 and ki-67 antibody status was diffusely positive in 12 out of 24 cases (50%) of leiomyosarcomas. Leiomyomas with bizzare nuclei were stained with Ki67 proliferative marker less than those in obviously malignant cases (P < 0.001). Estrogen and progesterone receptors had a reverse correlation with tumours malignancy potential.
  
  
  CONCLUSIONS
  Since p53 is known as an important inhibitory trigger for proliferative cycle of cells, in current study it was concluded that p53 inhibitory role decreases as malignancy potential increases, also tumors dependence on steroids via steroid receptors decreases as malignancy potential increases.
authors.affiliation: Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mahzad
authors.initials: M
authors.lastname: Azimpouran
authors.affiliation: Department of Obstetrics and Gynecology, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Shabnam
authors.initials: S
authors.lastname: Vazifekhah
authors.affiliation: Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Farnaz
authors.initials: F
authors.lastname: Moslemi
authors.affiliation: Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Piri
authors.affiliation: Students' Research Committee, Tabriz, Iran; Medical Education Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Naghavi-Behzad
keywords: Immunohistochemistry; leiomyoma; uterus