title: Comparison of Endothelial Function in Asian Indians Versus Caucasians.
abstract: Asian Indians have markedly increased mortality due to coronary artery disease (CAD). Impaired endothelial function has been linked to an increased risk of acute cardiovascular events. We tested the hypothesis that endothelial function was attenuated in Asian Indians and Caucasians.
  
  
  
  We studied 14 Asian Indians [mean age: 30 ± 6 years; mean body mass index (BMI): 25 ± 3 kg/m(2)] and 11 Caucasians (mean age: 30 ± 5 years; mean BMI: 26 ± 2 kg/m(2)). All 25 subjects were healthy men and nonsmokers without any history of CAD or diabetes and were not taking medications. Endothelial function was evaluated by ultrasound measures of flow-mediated dilatation (FMD) and endothelium-independent nonflow mediated vasodilatation (NFMD) of the brachial artery, in the morning immediately after awakening (6 a.m.) in a fasting state.
  
  
  
  Mean age, BMI, apnea-hypopnea index, heart rate, and blood pressure were similar in both groups (P = >0.05). When correcting for body surface area, brachial artery diameter was not different between the two groups (2.1% ± 0.3% vs. 2.2% ± 0.4%; P = 0.29). FMD and NFMD were similar in Asian Indians and Caucasians (5.9% ± 4.1% vs. 5.7% ± 2.6%, P = 0.70; 16.4% ± 8% vs. 14.8% ± 4.1%, P = 0.58, respectively).
  
  
  
  Endothelial function in Asian Indian men is not attenuated in comparison to Caucasian men.
authors.affiliation: 1 Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Minnesota , Minneapolis, Minnesota.
authors.forename: Snigdha
authors.initials: S
authors.lastname: Pusalavidyasagar
authors.affiliation: 2 Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, Minnesota.
authors.forename: Fatima H
authors.initials: FH
authors.lastname: Sert Kuniyoshi
authors.affiliation: 3 Cincinnati Children's Hospital, University of Cincinnati , Cincinnati, Ohio.
authors.forename: Abu S M
authors.initials: AS
authors.lastname: Shamsuzzaman
authors.affiliation: 2 Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, Minnesota.
authors.forename: Prachi
authors.initials: P
authors.lastname: Singh
authors.affiliation: 2 Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, Minnesota.
authors.forename: Shantal
authors.initials: S
authors.lastname: Maharaj
authors.affiliation: 2 Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, Minnesota.
authors.forename: Pavel
authors.initials: P
authors.lastname: Leinveber
authors.affiliation: 2 Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, Minnesota.
authors.forename: Jiri
authors.initials: J
authors.lastname: Nykodym
authors.affiliation: 2 Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, Minnesota.
authors.forename: Virend K
authors.initials: VK
authors.lastname: Somers
mesh_terms: D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data*; D001916:Brachial Artery / Q000502:physiology; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000208:ethnology* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006801:Humans; D007194:India / Q000208:ethnology; D008297:Male; D012307:Risk Factors; D014664:Vasodilation; D044465:White People / Q000706:statistics & numerical data*; D055815:Young Adult