title: Epigenetics: spotlight on type 2 diabetes and obesity.
abstract: Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research areas in biomedicine as changes in the epigenome are involved in many biological processes, impact on the risk for several complex diseases including diabetes and may explain susceptibility. In this review, we focus on the role of DNA methylation in contributing to the risk of T2D and obesity.
authors.affiliation: URT of the Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research, Naples, Italy.|Department of Translational Medical Sciences, University of Naples "Federico II", Via Pansini 5, 80131, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Desiderio
authors.affiliation: URT of the Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research, Naples, Italy.|Department of Translational Medical Sciences, University of Naples "Federico II", Via Pansini 5, 80131, Naples, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Spinelli
authors.affiliation: URT of the Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research, Naples, Italy.|Department of Translational Medical Sciences, University of Naples "Federico II", Via Pansini 5, 80131, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Ciccarelli
authors.affiliation: URT of the Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research, Naples, Italy.|Department of Translational Medical Sciences, University of Naples "Federico II", Via Pansini 5, 80131, Naples, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Nigro
authors.affiliation: URT of the Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research, Naples, Italy.|Department of Translational Medical Sciences, University of Naples "Federico II", Via Pansini 5, 80131, Naples, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Miele
authors.affiliation: URT of the Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research, Naples, Italy. beguino@unina.it.|Department of Translational Medical Sciences, University of Naples "Federico II", Via Pansini 5, 80131, Naples, Italy. beguino@unina.it.
authors.forename: F
authors.initials: F
authors.lastname: Beguinot
authors.affiliation: URT of the Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research, Naples, Italy.|Department of Translational Medical Sciences, University of Naples "Federico II", Via Pansini 5, 80131, Naples, Italy.
authors.forename: G A
authors.initials: GA
authors.lastname: Raciti
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D009765:Obesity / Q000235:genetics*
keywords: DNA methylation; Epigenetics; Obesity; Type 2 diabetes