title: Value of Ki-67 and computed tomography in the assessment of peripheral lung adenocarcinoma.
abstract: OBJECTIVE
  This study was designed to determine whether proliferation antigen Ki-67 and/or a computed tomography (CT) value could be used to evaluate the clinical-pathological features of peripheral lung adenocarcinoma.
  
  
  METHODS
  A total of 116 eligible lung cancer patients were enrolled. Nodule size, lymph node metastasis, differentiation, Ki-67 expression and CT findings were assessed. The relationship between clinic parameters and the CT feature was analysed statistically.
  
  
  RESULTS
  The percentage of lesions that had ground-glass opacity or localised air bronchogram was significantly greater in low CT value group (<30, p < 0.05). No significant association was observed between CT value and size in the subgroup with CT value > 0 (p = 0.66). As a proliferative marker of lung cancer, Ki-67 was present in a total of 115 (99.9%) of the 116 evaluable primary lung cancers. There was a statistically significant correlation between the Ki-67 index and CT value (p < 0.05). Compared to CT value, Ki-67 index possessed higher sensitivity to predict the differentiation and lymph node metastasis of peripheral lung adenocarcinoma, adding of CT value would enhance its specificity.
  
  
  CONCLUSIONS
  Combination of Ki-67 expression and CT value determination was useful for the classification of differentiation and metastatic or proliferative potential of peripheral lung adenocarcinoma.
authors.affiliation: a Respiratory Department , The First Affiliated Hospital of Soochow University , Suzhou , China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.affiliation: b Pathology Department , The First Affiliated Hospital of Soochow University , Suzhou , China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhu
authors.affiliation: a Respiratory Department , The First Affiliated Hospital of Soochow University , Suzhou , China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Zhang
authors.affiliation: a Respiratory Department , The First Affiliated Hospital of Soochow University , Suzhou , China.
authors.forename: Ye-Han
authors.initials: YH
authors.lastname: Zhu
authors.affiliation: a Respiratory Department , The First Affiliated Hospital of Soochow University , Suzhou , China.
authors.forename: Jian-An
authors.initials: JA
authors.lastname: Huang
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary / Q000601:surgery; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D002454:Cell Differentiation; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D008175:Lung Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen
keywords: CT value; Computed tomography (CT); lung adenocarcinoma