title: Use of urea and creatinine levels in vaginal fluid for the diagnosis of preterm premature rupture of membranes and delivery interval after membrane rupture.
abstract: OBJECTIVE
  To determine whether urea and creatinine measurements in vaginal fluid could be used to diagnose preterm premature rupture of membranes (PPROM) and predict delivery interval after PPROM.
  
  
  METHODS
  A prospective study conducted with 100 pregnant women with PPROM and 100 healthy pregnant women between 24 + 0 and 36 + 6 gestational weeks. All patients underwent sampling for urea and creatinine concentrations in vaginal fluid at the time of admission. Receiver operator curve analysis was used to determine the cutoff values for the presence of PPROM and delivery within 48 h after PPROM.
  
  
  RESULTS
  In multivariate logistic regression analysis, vaginal fluid urea and creatinine levels were found to be significant predictors of PPROM (p < 0.001 and p < 0.001, respectively) and delivery within 48 h after PPROM (p = 0.012 and p = 0.017, respectively). The optimal cutoff values for the diagnosis of PPROM were >6.7 mg/dl for urea and >0.12 mg/dl for creatinine. The optimal cutoff values for the detection of delivery within 48 h were >19.4 mg/dl for urea and >0.23 mg/dl for creatinine.
  
  
  CONCLUSIONS
  Measurement of urea and creatinine levels in vaginal fluid is a rapid and reliable test for diagnosing and also for predicting delivery interval after PPROM.
authors.affiliation: a Department of Perinatology and.
authors.forename: Cenk
authors.initials: C
authors.lastname: Gezer
authors.affiliation: a Department of Perinatology and.
authors.forename: Atalay
authors.initials: A
authors.lastname: Ekin
authors.affiliation: a Department of Perinatology and.
authors.forename: Ceren
authors.initials: C
authors.lastname: Golbasi
authors.affiliation: a Department of Perinatology and.
authors.forename: Ceysu
authors.initials: C
authors.lastname: Kocahakimoglu
authors.affiliation: b Department of Biochemistry , Tepecik Training and Research Hospital , Izmir , Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Bozkurt
authors.affiliation: a Department of Perinatology and.
authors.forename: Askin
authors.initials: A
authors.lastname: Dogan
authors.affiliation: a Department of Perinatology and.
authors.forename: Ulaş
authors.initials: U
authors.lastname: Solmaz
authors.affiliation: a Department of Perinatology and.
authors.forename: Hakan
authors.initials: H
authors.lastname: Golbasi
authors.affiliation: a Department of Perinatology and.
authors.forename: Cuneyt Eftal
authors.initials: CE
authors.lastname: Taner
mesh_terms: D000328:Adult; D001826:Body Fluids / Q000737:chemistry* / Q000378:metabolism; D003404:Creatinine / Q000032:analysis* / Q000378:metabolism; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis* / Q000378:metabolism; D005865:Gestational Age; D006801:Humans; D036801:Parturition / Q000502:physiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D013997:Time Factors; D014508:Urea / Q000032:analysis* / Q000378:metabolism; D014621:Vagina / Q000737:chemistry* / Q000378:metabolism; D055815:Young Adult
chemical_list: D014508:Urea; D003404:Creatinine
keywords: Creatinine; delivery interval; preterm premature rupture of membranes; urea; vaginal fluid