title: Individual Parameters of Cytokine Production in Healthy Siberian Caucasians.
abstract: The levels of spontaneous and concanavalin A-induced production of some key cytokines (TNF-α, IL-1β, IL-4, Il-6, and IL-10) were assessed in the cultures of mononuclear cells derived from healthy volunteers examined for polymorphism of the promotor sites of the respective genes. The presence of certain allelic variants in the promoter regions of human cytokine genes mostly determines the rates of induced and spontaneous cytokine production. Allelic variant -31C of IL-1β gene is associated with high production rate of the related cytokine. In addition, polymorphism of allelic variant C-590T of IL-4 gene significantly affects the production rates of IL-1β, TNF-α, IL-6, and IL-10.
authors.affiliation: Institute of Experimental and Clinical Lymphology, Novosibirsk, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Konenkov
authors.affiliation: Institute of Experimental and Clinical Lymphology, Novosibirsk, Russia. shalla@mail.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Shevchenko
authors.affiliation: Institute of Experimental and Clinical Lymphology, Novosibirsk, Russia.
authors.forename: V F
authors.initials: VF
authors.lastname: Prokof'ev
authors.affiliation: Institute of Experimental and Clinical Lymphology, Novosibirsk, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Poveshchenko
authors.affiliation: Institute of Experimental and Clinical Lymphology, Novosibirsk, Russia.
authors.forename: A P
authors.initials: AP
authors.lastname: Lykov
mesh_terms: D000328:Adult; D016207:Cytokines / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D012800:Siberia; D044465:White People; D055815:Young Adult
chemical_list: D016207:Cytokines
keywords: concanavalin A; cytokines; genotype; polymorphism; promoter region