title: [THE LONG NON-CODING RNA ASSOCIATED WITH CANCEROGENESIS: BIOLOGICAL SIGNIFICANCE AND PERSPECTIVES OF APPLICATION IN DIAGNOSTIC].
abstract: The last decade is characterized by development of such technologies as RNA-sequencing and biochips which resulted in discovery of new perspective biomarkersfor personalized diagnostic of cancer. Among them, the long non-coding RNA (IncRNA) are of special interest because according the recent studies they are positioned as important regulators of gene expression on epigenetic, transcription and post-transcription levels. The review considers the role of long non-coding RNA in cancerogenesis. The corresponding of their application in diagnostic is evaluated. A number of examples ofperspective diagnostic and prognostic markers. Their degree of implementation in oncological practice is discussed.
authors.forename: O I
authors.initials: OI
authors.lastname: Kit
authors.forename: E Yu
authors.initials: EY
authors.lastname: Kirichenko
authors.forename: Yu G
authors.initials: YG
authors.lastname: Kirichenko
authors.forename: I A
authors.initials: IA
authors.lastname: Novikova
authors.forename: O N
authors.initials: ON
authors.lastname: Selyutina
authors.forename: S Yu
authors.initials: SY
authors.lastname: Filippova
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D063646:Carcinogenesis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism; D011933:Reagent Kits, Diagnostic
chemical_list: D014408:Biomarkers, Tumor; C561518:CDKN2B antisense RNA, human; C561567:GAS5 long non-coding RNA, human; C561566:HOTAIR long untranslated RNA, human; C557041:MALAT1 long non-coding RNA, human; C588212:PCAT-1 lncRNA, human; D062085:RNA, Long Noncoding; D011933:Reagent Kits, Diagnostic; C515159:UCA1 RNA, human; C077885:XIST non-coding RNA