title: The effects of aqueous extract of babassu (Orbignya phalerata) on the pleura and lung parenchyma in rats.
abstract: OBJECTIVE
  To evaluate macro and microscopically, changes following the use of the aqueous extract of babassu (Orbignya phalerata) in the lung parenchyma and pleura of rats.
  
  
  METHODS
  Sixty adult male rats with average weight of 350 g, were randomized into two groups of 30 animals (experimental and control) further divided into sub-groups of 10 to be sacrificed at 48 h, 72 h and 21 days. The substance was injected into the right pleura of the animals.
  
  
  RESULTS
  There was intense pleuropulmonary macroscopic reaction with statistically significant differences between groups respectively (p<0.05, p<0.02, p<0.03). Microscopically, no statistically significant difference was evident (p>0.05).
  
  
  CONCLUSIONS
  The aqueous extract of babassu (Orbignya phalerata) was found to be highly irritating to the pleura and lung of rats, evidenced macroscopically by numerous adhesions and inflammation while no major changes were evident microscopically.
authors.affiliation: Department of Surgery, Universidade Federal do Maranhão, Sao Luis, MA, Brazil.
authors.forename: Elias
authors.initials: E
authors.lastname: Amorim
authors.affiliation: Santa Casa de São Paulo, Brazil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Saad Junior
authors.affiliation: Teaching Hospital, UFMA, Sao Luis, MA, Brazil.
authors.forename: Natalino
authors.initials: N
authors.lastname: Salgado Filho
authors.affiliation: Teaching Hospital, UFMA, Sao Luis, MA, Brazil.
authors.forename: George Castro Figueira de
authors.initials: GC
authors.lastname: Melo
authors.affiliation: Teaching Hospital, UFMA, Sao Luis, MA, Brazil.
authors.forename: Gyl Eanes Barros
authors.initials: GE
authors.lastname: Silva
authors.affiliation: School of Medicine, UFMA, Sao Luis, MA, Brazil.
authors.forename: Rennan Abud Pinheiro
authors.initials: RA
authors.lastname: Santos
authors.affiliation: School of Medicine, UFMA, Sao Luis, MA, Brazil.
authors.forename: Danilo Dallago de
authors.initials: DD
authors.lastname: Marchi
authors.affiliation: School of Medicine, UFMA, Sao Luis, MA, Brazil.
authors.forename: Ricardo Comunello de
authors.initials: RC
authors.lastname: Carli
authors.affiliation: Faculdade Evangélica do Paraná, Curitiba, PR, Brazil.
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Malafaia
authors.affiliation: FEPAR, Curitiba, PR, Brazil.
authors.forename: Jurandir
authors.initials: J
authors.lastname: Ribas-Filho
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D028023:Arecaceae / Q000737:chemistry*; D004195:Disease Models, Animal; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D010994:Pleura / Q000187:drug effects* / Q000473:pathology; D018700:Pleurodesis / Q000379:methods*; D011014:Pneumonia / Q000139:chemically induced; D011897:Random Allocation; D051381:Rats; D015203:Reproducibility of Results; D013997:Time Factors; D014945:Wound Healing
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts