title: Radiological, histological, and hematological evaluation of hydroxyapatite-coated resorbable magnesium alloy screws placed in rabbit tibia.
abstract: Titanium (Ti) screw has excellent mechanical property, and osseointegration capacity. However, they require surgery for removal. In contrast, polymer screws are resorbable, but they have poor mechanical properties. In this research, magnesium alloy screws (WE43: Mg-Y-Nd-Zr) that have advantages of titanium and polymer were manufactured. In addition, to increase biocompatibility and control degradation rate, the Mg alloy was coated with hydroxyapatite (HA). Torsion test and corrosion test were performed in vitro. For clinical, radiological and histological evaluation, on the eight rabbits, two HA-coated screws were installed in left tibia, and two noncoated screws were installed in right tibia. Each four rabbits were sacrificed 6 and 12 weeks postoperatively. For hematological evaluation, the same type of screws were installed on both legs. Complete blood count (CBC), Mg2+concentrate were sampled from the ear central artery on the operation day for a control point, and at 1, 2, 4, 6, 8, and 12 weeks. Mg alloy screws have no differences of biocompatibility according to the HA coating. However, resorption of screw was slower in case of the HA coating. The hematological problem related releasing of Mg was not found. The results suggest that Mg alloy screws have feasibility for clinical application. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1636-1644, 2017.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Clinical Trial Center, Seoul National University Dental Hospital, Seoul, Korea.|Department of Oral and Maxillofacial Surgery, Korea University Medical Center, Guro Hospital, Seoul, Korea.
authors.forename: Ho-Kyung
authors.initials: HK
authors.lastname: Lim
authors.affiliation: Department of Oral and Maxillofacial Surgery, Dongtan Sacred Heart Hospital, Hallym University Medical Center, Kyonggi-do, Korea.
authors.forename: Soo-Hwan
authors.initials: SH
authors.lastname: Byun
authors.affiliation: Department of Oral and Maxillofacial Surgery, Korea University Medical Center, Guro Hospital, Seoul, Korea.
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kyunghee University Dental Hospital, Seoul, Korea.
authors.forename: Jung-Woo
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Material Science and Engineering, Seoul National University, Seoul, Korea.
authors.forename: Sae-Mi
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Department of Material Science and Engineering, Seoul National University, Seoul, Korea.
authors.forename: Sung-Mi
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Department of Material Science and Engineering, Seoul National University, Seoul, Korea.
authors.forename: Hyoun-Ee
authors.initials: HE
authors.lastname: Kim
authors.affiliation: Department of Oral and Maxillofacial Surgery, Clinical Trial Center, Seoul National University Dental Hospital, Seoul, Korea.
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Lee
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001772:Blood Cell Count; D001863:Bone Screws; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology; D008274:Magnesium / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008422:Materials Testing; D011817:Rabbits; D013977:Tibia; D013997:Time Factors
chemical_list: D017886:Durapatite; D008274:Magnesium
keywords: HA coating; biocompatibility; bioresorbable screw; magnesium; magnesium alloy (WE43)