title: Experimental validation of talc pleurodesis for carcinomatous pleuritis in an animal model.
abstract: OBJECTIVE
  This study was performed to evaluate the change of pleural cavity by talc pleurodesis for carcinomatous pleuritis in an animal model.
  
  
  METHODS
  Models of malignant pleuritis were produced by an intra-venous injection of lung adenocarcinoma cells to male BALB/c nude mice at 6 weeks of age. Two weeks after the injection, either talc or saline was injected into the left thoracic cavity and the mice were further observed for 4 weeks. Six weeks after the injection, they were killed and the occurrence of lung cancer, amount of pleural effusion, and histological change of the pleural cavity were examined and compared between the two groups with or without talc administration.
  
  
  RESULTS
  Talc administration caused a significant reduction in pleural effusion with no increase of pleural adhesion. Talc administration resulted in marked pleural thickening compared to saline treatment. The vascular architecture and its area did not differ between the two groups.
  
  
  CONCLUSIONS
  Talc pleurodesis to reduce pleural effusion is valid for carcinomatous pleuritis, potentially through an acceleration of pleural thickening.
authors.affiliation: Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Iwasaki
authors.affiliation: Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan. stakam@med.kurume-u.ac.jp.
authors.forename: Shinzo
authors.initials: S
authors.lastname: Takamori
authors.affiliation: Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mitsuoka
authors.affiliation: Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Kashihara
authors.affiliation: Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nishi
authors.affiliation: Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
authors.forename: Daigo
authors.initials: D
authors.lastname: Murakami
authors.affiliation: Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Matsumoto
authors.affiliation: Institute of Animal Experimentation, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
authors.forename: Hiroharu
authors.initials: H
authors.lastname: Mifune
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tajiri
authors.affiliation: Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Akagi
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D000077192:Adenocarcinoma of Lung; D000818:Animals; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010996:Pleural Effusion / Q000209:etiology / Q000628:therapy*; D016066:Pleural Effusion, Malignant; D010998:Pleurisy / Q000209:etiology / Q000628:therapy*; D018700:Pleurodesis / Q000379:methods*; D013627:Talc / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D013627:Talc
keywords: Animal model; Carcinomatous pleuritis; Talc pleurodesis