title: Enterovirus and parechovirus infection in children: a brief overview.
abstract: Enterovirus and parechovirus are a frequent cause of infection in children. This review is an overview of what is known from enterovirus and parechovirus infection in children and contains information about the epidemiology, pathogenesis, clinical presentation, diagnosis, treatment, and prognosis of enterovirus and parechovirus infection in children.
  
  
  CONCLUSIONS
  EV and HPeV infections are a frequent cause of infection in childhood. The clinical presentation is diverse. RT-qPCR is the best way to detect an EV or HPeV. Cerebrospinal fluid, blood and feces have the highest sensitivity for detecting an EV or HPeV. There is no treatment for EV and HPeV infections. Two vaccines against EV 71 are just licensed in China and will be available on the private market. Little is known about the prognosis of EV and HPeV infections.
  
  
  BACKGROUND
  •EV and HPeV are a frequent cause of infection in children. What is new: •This review gives a brief overview over EV and HPeV infection in children.
authors.affiliation: Department of Pediatrics, St. Elisabeth Hospital, Tilburg, The Netherlands. stephanie_de_crom@hotmail.com.|Department of Pediatrics, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands. stephanie_de_crom@hotmail.com.
authors.forename: S C M
authors.initials: SC
authors.lastname: de Crom
authors.affiliation: Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: J W A
authors.initials: JW
authors.lastname: Rossen
authors.affiliation: Department of Pediatric Infectious Diseases Immunology and Rheumatology, VU Medical Centre, Amsterdam, The Netherlands.
authors.forename: A M
authors.initials: AM
authors.lastname: van Furth
authors.affiliation: Department of Pediatrics, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
authors.forename: C C
authors.initials: CC
authors.lastname: Obihara
mesh_terms: D002648:Child; D004770:Enterovirus / Q000302:isolation & purification / Q000472:pathogenicity; D004769:Enterovirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D030061:Parechovirus / Q000302:isolation & purification / Q000472:pathogenicity; D010850:Picornaviridae Infections / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D015995:Prevalence; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction
keywords: Children; Enterovirus; Infection; Overview; Parechovirus