title: Nerve biopsy in Indian patients with mononeuropathy multiplex of undetermined etiology.
abstract: A diagnosis of mononeuropathy multiplex (MM) requires detailed evaluation to determine etiology. We performed nerve biopsy on patients with MM in whom the etiology could not be established via other investigations.
  
  
  
  Sixty-eight patients with MM seen between January 2013 and June 2014 underwent detailed diagnostic evaluation. Those in whom the investigations failed to establish an etiology underwent nerve biopsy.
  
  
  
  A diagnosis of leprosy was confirmed in 14 patients and was highly probable in 17 others. Eleven patients had vasculitic neuropathy, and in 1 patient there were amyloid deposits on nerve biopsy.
  
  
  
  In 43 of 68 Indian patients (63%) with MM, nerve biopsy identified a definite (26 patients) or probable (17 patients) etiology. Nerve biopsy is a valuable investigation in MM that frequently results in a diagnosis of leprosy in India. Muscle Nerve, 2016 Muscle Nerve 55: 23-27, 2017.
authors.affiliation: Department of Neurology Dr Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomtinagar, Lucknow, Uttar Pradesh, 226010, India.
authors.forename: Dinkar
authors.initials: D
authors.lastname: Kulshreshtha
authors.affiliation: Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Gomtinagar, Lucknow, Uttar Pradesh, India.
authors.forename: Kiran Preet
authors.initials: KP
authors.lastname: Malhotra
authors.affiliation: Department of Neurology Dr Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomtinagar, Lucknow, Uttar Pradesh, 226010, India.
authors.forename: Pradeep Kumar
authors.initials: PK
authors.lastname: Maurya
authors.affiliation: Department of Neurology Dr Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomtinagar, Lucknow, Uttar Pradesh, 226010, India.
authors.forename: Ajai Kumar
authors.initials: AK
authors.lastname: Singh
authors.affiliation: Department of Neurology Dr Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomtinagar, Lucknow, Uttar Pradesh, 226010, India.
authors.forename: Anup Kumar
authors.initials: AK
authors.lastname: Thacker
authors.affiliation: Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Gomtinagar, Lucknow, Uttar Pradesh, India.
authors.forename: Nuzhat
authors.initials: N
authors.lastname: Husain
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D001706:Biopsy / Q000379:methods; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D020422:Mononeuropathies / Q000175:diagnosis*; D009412:Nerve Fibers / Q000473:pathology*; D055815:Young Adult
keywords: leprosy; mononeuropathy multiplex; nerve biopsy; undetermined etiology; vasculitis