title: Ag(I)-Catalyzed Indolization/C3-Functionalization Cascade of 2-Ethynylanilines via Ring Opening of Donor-Acceptor Cyclopropanes.
abstract: A AgSbF6-catalyzed cascade involving the ring opening of donor-acceptor cyclopropanes (DACs) preceded by the cyclization of N-protected 2-ethynylaniline is described. The method discloses a step-economy route to 2,3-disubstituted indole, where a Ag catalyst is found to trigger the cascade by activating both alkyne and DACs. Various functionalities at different ends of both substrates offer rapid access to 2,3-disubstituted indole derivatives in one pot in good to excellent yields. Elaboration of the cascade product to useful intermediates is also depicted.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal Bypass Road, Bhauri, Bhopal, Madhya Pradesh 462 066, India.
authors.forename: Raju
authors.initials: R
authors.lastname: Karmakar
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal Bypass Road, Bhauri, Bhopal, Madhya Pradesh 462 066, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Suneja
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhopal Bypass Road, Bhauri, Bhopal, Madhya Pradesh 462 066, India.|Indian Institute of Technology Kanpur , Kanpur, Uttar Pradesh 208 016, India.
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Singh