title: Theory of Mind Impairments in Youth at Clinical High Risk of Psychosis.
abstract: The normal maturational processes of theory of mind (ToM) capacity are ongoing during adolescence and even early adulthood. However, research has shown that ToM ability also declines among adults suffering from prodromal psychotic experiences. The goal of this study was to investigate the characteristics of ToM performance in youth with clinical high risk (CHR) of psychosis.
  
  
  
  The Reading Mind in Eyes Task (RMET), including own-race and other-race eyes, was administered to 40 CHR youth; 42 age-, gender-, and education-matched healthy controls (HCs); and 62 adult patients with schizophrenia (SZ). Nine-month follow-up data were collected from 31 CHR subjects, of whom 7 (22.6%) had made the transition to psychosis.
  
  
  
  CHR youth showed significant impairment in RMET performance compared to HC youth but performed better than did SZ patients. Moreover, they were significantly slower than were HC youth in responding to the RMET, with a response time similar to that of SZ patients. In particular, they had significantly poorer accuracy in interpreting positive and neutral eye expressions compared to the HC group, but not in interpreting negative eye expressions. Preliminary follow-up data showed a trend toward significance (p = 0.079) for RMET performance between those who transitioned to psychosis and those who did not.
  
  
  
  Our findings illustrate that deficits in ToM capacity, specifically the ability to interpret people's mental state from eye expressions, occur early on in prodromal psychosis in youth. Early interventions for CHR youth focusing on ToM enhancement may halt progress toward psychosis.
authors.forename: TianHong
authors.initials: T
authors.lastname: Zhang
authors.forename: YingYing
authors.initials: Y
authors.lastname: Tang
authors.forename: HuiRu
authors.initials: H
authors.lastname: Cui
authors.forename: Xi
authors.initials: X
authors.lastname: Lu
authors.forename: LiHua
authors.initials: L
authors.lastname: Xu
authors.forename: XiaoHua
authors.initials: X
authors.lastname: Liu
authors.forename: HuiJun
authors.initials: H
authors.lastname: Li
authors.forename: Annabelle
authors.initials: A
authors.lastname: Chow
authors.forename: YaSong
authors.initials: Y
authors.lastname: Du
authors.forename: ChunBo
authors.initials: C
authors.lastname: Li
authors.forename: KaiDa
authors.initials: K
authors.lastname: Jiang
authors.forename: ZePing
authors.initials: Z
authors.lastname: Xiao
authors.forename: JiJun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D062706:Prodromal Symptoms; D011618:Psychotic Disorders / Q000503:physiopathology*; D012306:Risk; D012559:Schizophrenia / Q000503:physiopathology*; D056345:Theory of Mind / Q000502:physiology*; D055815:Young Adult