title: Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of familial breast cancer.
abstract: Single nucleotide polymorphisms (SNPs) are accumulated frequently in the mitochondrial displacement loop (D-loop) in various types of cancer, and their association with cancer risk and disease outcome has been extensively identified. We have identified specific risk-associated SNP for familial breast cancer patients previously. In this study, we investigated the association between age-at-onset and the SNPs in familial breast cancer patients. The SNP sites of nucleotides 16 311 T/C were identified for their association with age-at-onset using the log-rank test. The age-at-onset of the patients with the minor allele C genotype was significantly earlier than that of patients carrying the T genotype at the site 16 311 (p = 0.032). Accordingly, the genetic polymorphisms in the mitochondrial D-loop are predictive markers for age-at-onset in familial breast cancer patients, which may help to identify familial breast cancer patient subgroups at high risk of early onset.
authors.affiliation: a Hebei Breast Cancer Center, The Fourth Hospital of Hebei Medical University , Shijiazhuang , PR China and.
authors.forename: Haiping
authors.initials: H
authors.lastname: Lee
authors.affiliation: a Hebei Breast Cancer Center, The Fourth Hospital of Hebei Medical University , Shijiazhuang , PR China and.
authors.forename: Cuizhi
authors.initials: C
authors.lastname: Geng
authors.affiliation: a Hebei Breast Cancer Center, The Fourth Hospital of Hebei Medical University , Shijiazhuang , PR China and.
authors.forename: Meng
authors.initials: M
authors.lastname: Cheng
authors.affiliation: a Hebei Breast Cancer Center, The Fourth Hospital of Hebei Medical University , Shijiazhuang , PR China and.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Lee
authors.affiliation: b Department of Gastroenterology and Hepatology , The Fourth Hospital of Hebei Medical University , Shijiazhuang , PR China.
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000483:Alleles; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D004272:DNA, Mitochondrial; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D018570:Risk Assessment
chemical_list: D004272:DNA, Mitochondrial
keywords: Age-at-onset; D-loop; Kaplan–Meier method; familial breast cancer; genetic polymorphisms