title: Regulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human Disease.
abstract: The lysine acetyltransferase 6 (KAT6) histone acetyltransferase (HAT) complexes are highly conserved from yeast to higher organisms. They acetylate histone H3 and other nonhistone substrates and are involved in cell cycle regulation and stem cell maintenance. In addition, the human KAT6 HATs are recurrently mutated in leukemia and solid tumors. Therefore, it is important to understand the mechanisms underlying the regulation of KAT6 HATs and their roles in cell cycle progression. In this minireview, we summarize the identification and analysis of the KAT6 complexes and discuss the regulatory mechanisms governing their enzymatic activities and substrate specificities. We further focus on the roles of KAT6 HATs in regulating cell proliferation and stem cell maintenance and review recent insights that aid in understanding their involvement in human diseases.
authors.affiliation: Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei, Taiwan.
authors.forename: Fu
authors.initials: F
authors.lastname: Huang
authors.affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, USA Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, USA SMA@stowers.org JLW@stowers.org.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Abmayr
authors.affiliation: Stowers Institute for Medical Research, Kansas City, Missouri, USA SMA@stowers.org JLW@stowers.org.
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Workman
mesh_terms: D000107:Acetylation; D002453:Cell Cycle; D051548:Histone Acetyltransferases / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics; D065886:Neurodevelopmental Disorders / Q000201:enzymology* / Q000235:genetics; D013234:Stem Cells / Q000166:cytology / Q000201:enzymology; D013379:Substrate Specificity
chemical_list: D006657:Histones; D051548:Histone Acetyltransferases; C108712:KAT6A protein, human; C487137:KAT6B protein, human