title: Diagnostic value of Tg and TgAb for metastasis following ablation in patients with differentiated thyroid carcinoma coexistent with Hashimoto thyroiditis.
abstract: OBJECTIVE
  This study was designed to investigate the clinical value of serum thyroglobulin (Tg) and antithyroglobulin antibody (TgAb) measurements and the cutoff value after ablation in differentiated thyroid carcinoma (DTC) complicated by Hashimoto thyroiditis (HT) with metastasis.
  
  
  METHODS
  We measured serum Tg and TgAb levels and evaluated the disease status in 164 cases of DTC coexistent with HT in pathologically confirmed patients after surgery and post-remnant ablation during a 3-year follow-up. All Tg and TgAb levels were assessed by chemiluminescent immunoassay (IMA). Receiver operating characteristic (ROC) curve analysis was used to evaluate the prognostic value of Tg and TgAb for disease metastasis. The relationship between Tg and TgAb was analyzed using the scatter diagram distribution method.
  
  
  RESULTS
  We found that the cutoff values of Tg and TgAb were 1.48 µg/L and 45 kIU/L, respectively. The area under the ROC curve (AUC) of Tg and TgAb was 0.907 and 0.650, respectively.
  
  
  CONCLUSIONS
  In DTC coexistent with HT patients, the optimal cutoff value correlated with metastasis in Tg and TgAb was 1.48 µg/L and 45 kIU/L, respectively.
authors.affiliation: a Department of Nuclear Medicine , Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chai
authors.affiliation: b Department of Orthopedics , Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , People's Republic of China.
authors.forename: Zhao-Jin
authors.initials: ZJ
authors.lastname: Zhu
authors.affiliation: a Department of Nuclear Medicine , Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , People's Republic of China.
authors.forename: Ze-Quan
authors.initials: ZQ
authors.lastname: Chen
authors.affiliation: a Department of Nuclear Medicine , Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , People's Republic of China.
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D002277:Carcinoma / Q000097:blood*; D005260:Female; D050031:Hashimoto Disease / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012680:Sensitivity and Specificity; D013954:Thyroglobulin / Q000097:blood*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D014408:Biomarkers, Tumor; C006606:anti-thyroglobulin; D013954:Thyroglobulin
keywords: Differentiated thyroid carcinoma; Hashimoto thyroiditis; Tg; TgAb