title: Neuroprotective effect of lidocaine: is there clinical potential?
abstract: Local anesthetic lidocaine has been shown to be protective in animal models of focal and global ischemia as well as in in vitro hypoxic models. Lidocaine has been tested in patients for its potential protective effect on postoperative cognitive dysfunction. This mini-review summarizes the laboratory and clinical evidences and discusses its clinical applications as neuroprotective agent.
authors.affiliation: Neuroscience Institute, Morehouse School of Medicine Atlanta, GA 30310, USA.
authors.forename: Tiandong
authors.initials: T
authors.lastname: Leng
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University Guangzhou, Guangdong 510080, P.R. China.
authors.forename: Xiuren
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Anesthesiology, Stony Brook University Health Sciences Center, Stony Brook NY 11794-8480, USA.
authors.forename: James P
authors.initials: JP
authors.lastname: Dilger
authors.affiliation: Department of Anesthesiology, Stony Brook University Health Sciences Center, Stony Brook NY 11794-8480, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
keywords: Lidocaine; neuroprotection; postoperative cognitive dysfunction; stroke