title: Could physical exercise help modulate the gut microbiota in chronic kidney disease?
abstract: Chronic kidney disease (CKD) patients have several metabolic disorders caused by chronic oxidative stress and inflammation. The imbalance of gut microbiota has been identified as a factor that may contribute to the development of these disorders, which can promote cardiovascular disease in CKD patients. Among several strategies to modulate gut microbiota, physical exercise could represent a new nonpharmacological approach. Although exercise can reduce cardiovascular risk in CKD patients through its beneficial effects on oxidative stress and inflammation, there are no available data regarding the relationship between exercise and modulation of gut microbiota in CKD patients. This review is intended to provide a brief overview of the hypothesis regarding gut microbiota modulation through physical exercise, with a particular emphasis on CKD.
authors.affiliation: Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, Rio de Janeiro (RJ), Brazil.
authors.forename: Marta
authors.initials: M
authors.lastname: Esgalhado
authors.affiliation: Graduate Program in Medical Sciences, Fluminense Federal University (UFF), Niterói, Rio de Janeiro (RJ), Brazil.
authors.forename: Natália A
authors.initials: NA
authors.lastname: Borges
authors.affiliation: Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, Rio de Janeiro (RJ), Brazil.|Graduate Program in Medical Sciences, Fluminense Federal University (UFF), Niterói, Rio de Janeiro (RJ), Brazil.
authors.forename: Denise
authors.initials: D
authors.lastname: Mafra
mesh_terms: D000818:Animals; D015444:Exercise; D005081:Exercise Therapy; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000276:immunology / Q000382:microbiology* / Q000628:therapy*
keywords: chronic kidney disease; gut microbiota; physical exercise