title: Chiral Phosphoric Acid Catalyzed Diastereo- and Enantioselective Mannich-Type Reaction between Enamides and Thiazolones.
abstract: An enantioselective Mannich-type reaction between enamides, serving as aliphatic imine equivalents, and thiazolones or an azlactone, serving as α-amino acid derived pronucleophiles, was investigated using a chiral phosphoric acid catalyst. By using thiazolones, Mannich adducts with a tetrasubstituted chiral carbon center at the α-position and an aliphatic substituent at the β-position were efficiently obtained with high diastereo- and enantioselectivities.
authors.forename: Jun
authors.initials: J
authors.lastname: Kikuchi
authors.affiliation: Institute for Molecular Science and SOKENDAI (The Graduate University for Advanced Studies) , Okazaki, Aichi 444-8787, Japan.
authors.forename: Norie
authors.initials: N
authors.lastname: Momiyama
authors.forename: Masahiro
authors.initials: M
authors.lastname: Terada