title: Effects of intraoperative diltiazem infusion on flow changes in arterial and venous grafts in coronary artery bypass graft surgery.
abstract: OBJECTIVE
  This study aimed to show the effects of intra-operative diltiazem infusion on flow in arterial and venous grafts in coronary artery bypass graft surgery.
  
  
  METHODS
  Hundred fourty patients with a total of 361 grafts [205 (57%) arterial and 156 (43%) venous] underwent isolated coronary surgery. All the grafts were measured by intraoperative transit time flow meter intra-operatively. Group A (n=70) consisted of patients who received diltiazem infusion (dose of 2.5 microgram/kg/min), and Group B (n=70) didn't receive diltiazem infusion.
  
  
  RESULTS
  Mean graft flow values of left internal mammary artery were 53 ml/min in Group A and 40 ml/min in Group B (P<0.001). Pulsatility index (PI) values of left internal mammary artery for Group A and Group B were 2.6 and 3.0 respectively (P<0.001). No statistically significant difference was found between venous graft parameters.
  
  
  CONCLUSIONS
  We recommend an effect of diltiazem infusion in increasing graft flows in coronary artery bypass graft operations.
authors.affiliation: School of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Ozan
authors.initials: O
authors.lastname: Erdem
authors.affiliation: School of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Mehmet Erdem
authors.initials: ME
authors.lastname: Memetoğlu
authors.affiliation: School of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Ali İhsan
authors.initials: Aİ
authors.lastname: Tekin
authors.affiliation: School of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Ümit
authors.initials: Ü
authors.lastname: Arslan
authors.affiliation: School of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Akkaya
authors.affiliation: Denizli State Hospital, Denizli, Turkey.
authors.forename: Rasim
authors.initials: R
authors.lastname: Kutlu
authors.affiliation: School of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: İlhan
authors.initials: İ
authors.lastname: Gölbaşı
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001026:Coronary Artery Bypass / Q000379:methods*; D003326:Coronary Circulation / Q000187:drug effects*; D004110:Diltiazem / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D045268:Flowmeters; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods*; D007387:Internal Mammary-Coronary Artery Anastomosis; D007430:Intraoperative Care / Q000379:methods*; D008297:Male; D008323:Mammary Arteries / Q000601:surgery; D008875:Middle Aged; D015425:Myocardial Reperfusion; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D058017:Vascular Grafting / Q000379:methods*
chemical_list: D000959:Antihypertensive Agents; D004110:Diltiazem