title: [Correlation between serum free fatty acid level and estimated glomerular filtration rate in type 2 diabetic patients].
abstract: OBJECTIVE
  To investigate the relationship between serum free fatty acid (FFA) level and glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  A total of 442 T2DM patients treated in Sir Run Run Shaw Hospital from January 2013 to June 2015 were retrospectively analyzed and divided into three groups according to estimated glomerular filtration rate (eGFR) levels using modified modification of diet in renal disease (MDRD) formula: eGFR≥90 ml·min(-1)·1.73 m(-2)group (group A, 227 cases), 60 ml·min(-1)·1.73 m(-2)≤eGFR<90 ml·min(-1)·1.73 m(-2)group (group B, 118 cases), and eGFR<60 ml·min(-1)·1.73 m(-2)group (group C, 97 cases). In addition, 50 body mass index (BMI)-matched non-diabetic subjects were selected as control group. Fasting serum FFA level was measured in each group, and its relationship with eGFR was analyzed.
  
  
  RESULTS
  FFA level in group C[(450±203)μmol/L]was significantly higher than that in group A[(326±167)μmol/L], group B[(394±184)μmol/L]and control group[(320±90)μmol/L](all P<0.05). Meanwhile, FFA level in group B was higher compared with that in group A (P<0.05). However, no statistical difference was found in FFA level between group A and Control group (P>0.05). Multiple linear regression analysis using eGFR as the dependent variable demonstrated that uric acid (UA), FFA, triglyceride (TG), total cholesterol (TC), albuminuria, hypertension, smoking and duration of diabetes were all independent risk factors for decreased eGFR (all P<0.05).
  
  
  CONCLUSIONS
  The present results suggest that increased FFA level might be involved in the development of diabetic nephropathy.
authors.affiliation: Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Xuan
authors.forename: Fenping
authors.initials: F
authors.lastname: Zheng
authors.forename: Xihua
authors.initials: X
authors.lastname: Lin
authors.forename: Weifen
authors.initials: W
authors.lastname: Zhu
authors.forename: Xueyao
authors.initials: X
authors.lastname: Yin
authors.forename: Hong
authors.initials: H
authors.lastname: Li
mesh_terms: D000419:Albuminuria; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2; D005230:Fatty Acids, Nonesterified; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension; D012189:Retrospective Studies; D012307:Risk Factors; D014280:Triglycerides; D014527:Uric Acid
chemical_list: D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D014527:Uric Acid