title: Protective effects of taurine in traumatic brain injury via mitochondria and cerebral blood flow.
abstract: In mammalian tissues, taurine is an important natural component and the most abundant free amino acid in the heart, retina, skeletal muscle, brain, and leukocytes. This study is to examine the taurine's protective effects on neuronal ultrastructure, the function of the mitochondrial respiratory chain complex, and on cerebral blood flow (CBF). The model of traumatic brain injury (TBI) was made for SD rats by a fluid percussion device, with taurine (200 mg/kg) administered by tail intravenous injection once daily for 7 days after TBI. It was found that CBF was improved for both left and right brain at 30 min and 7 days post-injury by taurine. Reaction time was prolonged relative to the TBI-only group. Neuronal damage was prevented by 7 days taurine. Mitochondrial electron transport chain complexes I and II showed greater activity with the taurine group. The improvement by taurine of CBF may alleviate edema and elevation in intracranial pressure. Importantly taurine improved the hypercoagulable state.
authors.affiliation: National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing, 100050, China.|Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurological Institute, Tianjin Huanhu Hospital, No. 6 Jizhao Road, Jinnan District, Tianjin, 300350, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurological Institute, Tianjin Huanhu Hospital, No. 6 Jizhao Road, Jinnan District, Tianjin, 300350, China.
authors.forename: Weijia
authors.initials: W
authors.lastname: Fan
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurological Institute, Tianjin Huanhu Hospital, No. 6 Jizhao Road, Jinnan District, Tianjin, 300350, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurological Institute, Tianjin Huanhu Hospital, No. 6 Jizhao Road, Jinnan District, Tianjin, 300350, China.
authors.forename: Qiaoli
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurological Institute, Tianjin Huanhu Hospital, No. 6 Jizhao Road, Jinnan District, Tianjin, 300350, China.
authors.forename: Lidong
authors.initials: L
authors.lastname: Mo
authors.affiliation: National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing, 100050, China.
authors.forename: Zhenwu
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurological Institute, Tianjin Huanhu Hospital, No. 6 Jizhao Road, Jinnan District, Tianjin, 300350, China. huanghuiling@126.com.
authors.forename: Huiling
authors.initials: H
authors.lastname: Huang
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001929:Brain Edema / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D000070642:Brain Injuries, Traumatic / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004195:Disease Models, Animal; D042967:Electron Transport Complex I / Q000378:metabolism; D042963:Electron Transport Complex II / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000494:pharmacology*
chemical_list: D013654:Taurine; D042963:Electron Transport Complex II; D042967:Electron Transport Complex I
keywords: Cerebral blood flow; Mitochondrion; Taurine; Traumatic brain injury