title: [Autoimmune reactions in psoriasis : Spotlight].
abstract: BACKGROUND
  Psoriasis is a human leukocyte antigen (HLA)-associated T‑cell-mediated disorder.
  
  
  OBJECTIVE
  The role of the main psoriasis risk allele HLA-C*06:02 in disease manifestation and the mechanisms which activate the pathogenic T‑cell response in the skin of psoriasis patients remained elusive.
  
  
  METHODS
  Key to the immune pathogenesis of psoriasis was the analysis of the specificity of the infiltrating lesional psoriatic CD8(+) T cells
  
  
  CONCLUSIONS
  Analyses of the lesional psoriatic T‑cell reactivity demonstrate that psoriasis is an autoimmune disease. It is based on an autoimmune response against melanocytes which is preferentially mediated by HLA-C*06:02 through autoantigen presentation. Here we discuss the mechanisms of this autoimmune response in the context of the polygenic psoriatic predisposition.
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, Ludwig-Maximilians-Universität, Frauenlobstr. 9-11, 80337, München, Deutschland. joerg.prinz@med.uni-muenchen.de.
authors.forename: J C
authors.initials: JC
authors.lastname: Prinz
mesh_terms: D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D015236:HLA-C Antigens / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D018448:Models, Immunological; D011565:Psoriasis / Q000276:immunology*; D012867:Skin / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D001324:Autoantigens; D015236:HLA-C Antigens; C471431:HLA-C*01:06 antigen
keywords: Autoantigen; Autoimmune disease; Melanocytes; Pathogenesis; Psoriasis vulgaris