title: Treatment of Metastatic, Refractory Alveolar Soft Part Sarcoma: Case Reports and Literature Review of Treatment Options in the Era of Targeted Therapy.
abstract: Alveolar soft part sarcoma is a rare soft tissue sarcoma that is characterized by a pattern of slow growth with metastases to the lung, bone, and brain that is not responsive to conventional cytotoxic chemotherapy.
  
  
  
  We describe 2 patients, with a combined 19 years of treatment experience including multiple different chemotherapeutic and targeted therapy regimens, surgery, and radiotherapy. We also present a review of the literature regarding treatment options to highlight recent findings.
  
  
  
  Alveolar soft part sarcoma is an indolent, but persistently progressive disease. Novel therapeutic agents hold promise in its management.
authors.affiliation: *Division of Pediatric Hematology-Oncology, Rady Children's Hospital-San Diego, University of California, San Diego, CA †Division of Pediatric Hematology-Oncology, St Joseph's Children's Hospital, Paterson, NJ ‡Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Columbia University Medical Center, New York, NY.
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Kuo
authors.forename: Jill S
authors.initials: JS
authors.lastname: Menell
authors.forename: Julia L
authors.initials: JL
authors.lastname: Glade Bender
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis / Q000473:pathology*; D011878:Radiotherapy; D018234:Sarcoma, Alveolar Soft Part / Q000473:pathology / Q000628:therapy*; D013514:Surgical Procedures, Operative