title: Computational modeling approaches in gonadotropin signaling.
abstract: Follicle-stimulating hormone and LH play essential roles in animal reproduction. They exert their function through binding to their cognate receptors, which belong to the large family of G protein-coupled receptors. This recognition at the plasma membrane triggers a plethora of cellular events, whose processing and integration ultimately lead to an adapted biological response. Understanding the nature and the kinetics of these events is essential for innovative approaches in drug discovery. The study and manipulation of such complex systems requires the use of computational modeling approaches combined with robust in vitro functional assays for calibration and validation. Modeling brings a detailed understanding of the system and can also be used to understand why existing drugs do not work as well as expected, and how to design more efficient ones.
authors.affiliation: BIOS group, INRA, UMR85, Unité Physiologie de la Reproduction et des Comportements, Nouzilly, France; CNRS, UMR7247, Nouzilly, France; Université François Rabelais, Tours, France.
authors.forename: Mohammed Akli
authors.initials: MA
authors.lastname: Ayoub
authors.affiliation: BIOS group, INRA, UMR85, Unité Physiologie de la Reproduction et des Comportements, Nouzilly, France; CNRS, UMR7247, Nouzilly, France; Université François Rabelais, Tours, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Yvinec
authors.affiliation: BIOS group, INRA, UMR85, Unité Physiologie de la Reproduction et des Comportements, Nouzilly, France; CNRS, UMR7247, Nouzilly, France; Université François Rabelais, Tours, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Crépieux
authors.affiliation: BIOS group, INRA, UMR85, Unité Physiologie de la Reproduction et des Comportements, Nouzilly, France; CNRS, UMR7247, Nouzilly, France; Université François Rabelais, Tours, France. Electronic address: Anne.Poupon@tours.inra.fr.
authors.forename: Anne
authors.initials: A
authors.lastname: Poupon
mesh_terms: D000818:Animals; D003198:Computer Simulation; D005260:Female; D006062:Gonadotropins / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D010053:Ovary / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013737:Testis / Q000502:physiology*
chemical_list: D006062:Gonadotropins
keywords: Gonadotropins; Mathematical modeling; Systems biology