title: Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract.
abstract: MicroRNAs (miRNAs) are a type of small noncoding RNA that can regulate the expression of target genes under physiological and pathophysiological conditions. miR-155 is a multifunctional miRNA with inflammation-related and oncogenic roles. In particular, the dysregulation of miR-155 has been strongly implicated in Helicobacter pylori-related gastric disease, inflammatory bowel disease, and colorectal cancer in addition to being involved in molecular changes of important targets and signaling pathways. This review focuses on the expression and function of miR-155 during inflammation and carcinogenesis and its potential use as an effective therapeutic target for certain gastrointestinal diseases.
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China. 18942337437@163.com.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Wan
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China. liangx96180@126.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Xia
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China. xuwentncdx@foxmail.com.
authors.forename: Wenting
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China. lunonghua@ncu.edu.cn.
authors.forename: Nonghua
authors.initials: N
authors.lastname: Lu
mesh_terms: D000818:Animals; D005767:Gastrointestinal Diseases / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C524942:MIRN155 microRNA, human; D035683:MicroRNAs
keywords: H. Pylori; colorectal cancer; inflammatory bowel disease; miR-155