title: The association between oxidative stress, activator protein-1, inflammatory, total antioxidant status and artery stiffness and the efficacy of olmesartan in elderly patients with mild-to-moderate essential hypertension.
abstract: This study investigated the change of oxidative stress, activator protein-1 (AP-1), inflammatory, total antioxidant status (TAS) and artery stiffness, and explored the relationship between these characteristics and the efficacy of olmesartan intervention in elderly patients with mild-to-moderate essential hypertension (EH). In total, 386 elderly patients with EH and 353 normotensive controls were recruited. All study subjects had oxidative stress markers, AP-1, inflammatory factors, TAS and brancial-ankle artery pulse wave velocity (ba-PWV) measured. In total, 193 elderly patients with EH were randomized to olmesartan and were matched with 193 normotensive controls to observe the change of index above mentioned before and after the treatment. Compared with the controls, superoxide dismutase (SOD) and TAS were significantly reduced in patients with EH, and malondialdehyde (MDA), AP-1, high-sensitivity C-reactive protein (Hs-CRP), Monocyte Chemoattractant Protein-1 (MCP-1), heart rate， endothelin-1 (ET-1), TAS and ba-PWV were significantly increased (P < 0.01 for all). Pearson's correlation analysis showed that SOD and TAS were negatively related to AP-1 (P < 0.05 for all), and that blood pressure (BP), age, MDA, Hs-CRP, MCP-1, ET-1 were positively related to AP-1 (P < 0.01 for all). Multivariate linear regression analysis showed that BP, SOD, MDA, AP-1, Hs-CRP, MCP-1, ET-1, TAS, heart rate and age were independent risk factors for ba-PWV. After treatment with olmesartan, SOD and TAS were increased, while BP, heart rate, AP-1 and inflammatory factors were reduced with significant improvement in ba-PWV (P < 0.05 for all). More increase of arterial stiffness was reported in elderly hypertensive patients with greater oxidative stress, inflammatory, AP-1, heart rate, and lower TAS. Higher oxidative stress, AP-1 and inflammatory may predict higher arterial stiffness. Olmesartan may increase TAS, yet inhibit oxidative stress, AP-1, inflammatory, and heart rate with improved artery stiffness in elderly hypertensive patients.
authors.affiliation: a Department of Cardiology , Civil Aviation General Hospital Affiliated to BeiJing University , Beijing , PR China.
authors.forename: Qunwei
authors.initials: Q
authors.lastname: Liu
authors.affiliation: a Department of Cardiology , Civil Aviation General Hospital Affiliated to BeiJing University , Beijing , PR China.
authors.forename: Limin
authors.initials: L
authors.lastname: Han
authors.affiliation: a Department of Cardiology , Civil Aviation General Hospital Affiliated to BeiJing University , Beijing , PR China.
authors.forename: Qiufan
authors.initials: Q
authors.lastname: Du
authors.affiliation: b Department of Cardiology , An Zhen Hospital Affiliated to Capital Medical University , Beijing , PR China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: c Department of Cardiology , Xiangya Second Hospital of Central South University , Changsha , PR China.
authors.forename: Shenghua
authors.initials: S
authors.lastname: Zhou
authors.affiliation: c Department of Cardiology , Xiangya Second Hospital of Central South University , Changsha , PR China.
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Shen
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002097:C-Reactive Protein / Q000378:metabolism; D016903:Drug Monitoring / Q000379:methods; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D063177:Pulse Wave Analysis / Q000379:methods; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000097:blood; D013777:Tetrazoles / Q000008:administration & dosage / Q000009:adverse effects; D018808:Transcription Factor AP-1 / Q000097:blood; D016896:Treatment Outcome; D059289:Vascular Stiffness / Q000187:drug effects / Q000502:physiology
chemical_list: D000959:Antihypertensive Agents; D015415:Biomarkers; D007093:Imidazoles; D013777:Tetrazoles; D018808:Transcription Factor AP-1; D008315:Malondialdehyde; C437965:olmesartan; D002097:C-Reactive Protein; D013482:Superoxide Dismutase
keywords: Activator protein-1; artery stiffness; elderly patients; inflammatory; mild-to-moderate essential hypertension; olmesartan; oxidative stress; total antioxidant status