title: One-stage Penile Urethroplasty Using Oral Mucosal Graft and Glue.
abstract: Repair of penile urethral strictures is a challenging problem for which different techniques have been suggested.
  
  
  
  To describe a new surgical technique for one-stage penile urethroplasty using an oral graft and glue, and to assess its safety and efficacy.
  
  
  
  A retrospective review of medical records for patients who underwent one-stage penile urethroplasty using oral mucosa and glue from February 2013 to October 2014 was performed.
  
  
  
  The penile urethra was opened and the urethral plate was incised to create a wide window within which the oral graft was pasted with glue. The urethra was sutured over the catheter.
  
  
  
  Clinical data were collected in a database. Intraoperative and postoperative complications and outcomes were assessed. A descriptive statistical analysis was performed.
  
  
  
  Fourteen patients were included in the study. Median operative time was 60min. The median postoperative stay was 3 d. Three intraoperative and one postoperative complication occurred. In all patients, voiding cystourethrography 2 wk after surgery failed to show urethral fistula or sacculation. No patients complained of penile chordee or sexual dysfunction after surgery. Median follow-up was 16 mo. Among the 14 patients, 12 (85.7%) procedures were successful and two (14.3%) were failures. Study limitations include the small sample size and short follow-up.
  
  
  
  An in vitro study and a one-stage reconstruction of penile urethral strictures with an oral mucosa graft and glue showed that the procedure is safe and efficient, but further studies including larger series of patients and longer follow-up are required.
  
  
  
  We report on the repair of penile urethral stricture using one-stage urethroplasty with oral mucosa and glue. This new technique was safe and effective, with limited complications and satisfactory outcomes. We plan to increase the use of this technique in the future.
authors.affiliation: Centro Chirurgico Toscano, Arezzo, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Barbagli
authors.affiliation: Centre for Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: Graziella
authors.initials: G
authors.lastname: Pellegrini
authors.affiliation: Centre for Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Corradini
authors.affiliation: Division of Oncology, Unit of Urology, IRCCS Ospedale San Raffaele, Milan, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Montorsi
authors.affiliation: Department of Experimental Medicine and Surgery, University of Tor Vergata, Rome, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Sansalone
authors.affiliation: Research Institute for Uronephrology, Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: Denis
authors.initials: D
authors.lastname: Butnaru
authors.affiliation: Department of Urology, Istituto Clinico Humanitas IRCCS, Clinical and Research Center, Rozzano, Italy. Electronic address: massimo.lazzeri@humanitas.it.
authors.forename: Massimo
authors.initials: M
authors.lastname: Lazzeri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003487:Cyanoacrylates / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000637:transplantation*; D010413:Penis; D011183:Postoperative Complications / Q000453:epidemiology; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014525:Urethral Stricture / Q000601:surgery*; D013521:Urologic Surgical Procedures, Male / Q000379:methods*
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; C421461:glubran 2
keywords: Glue; One-stage urethroplasty; Oral mucosal graft; Penile stricture