title: Are serum gamma-glutamyl transferase, high-sensitivity C-reactive protein, and ischaemia-modified albumin useful in diagnosing PCOS?
abstract: We assessed the serum levels of gamma-glutamyl transferase (GGT), high-sensitivity C-reactive protein (hsCRP) and ischaemia-modified albumin (IMA) in patients with polycystic ovary syndrome (PCOS). Fifty-three patients with PCOS were included in our study along with 40 women with no PCOS as the control group. The patients were divided according to their body mass index (BMI). GGT levels were significantly higher in the women with PCOS than the women in the control group (p < 0.05). They were also significantly higher in the PCOS women who were normoweight and overweight than the normoweight and overweight women in the control group (p < 0.001). There was no significant difference in the circulating levels of hsCRP and IMA between the women with PCOS and the controls or between the normoweight and overweight subgroups. GGT may be associated with the diagnosis of PCOS when the threshold is set at >15.5 U/L. With the application of this threshold, raised GGT levels had 83% sensitivity (95% CI 0.70-0.90) and 67.5% specificity (95% CI 0.52-0.79), for the diagnosis of PCOS. In our study, GGT levels were elevated in the PCOS patients independent of BMI and could thus be an important marker of PCOS.
authors.affiliation: a Department of Obstetrics and Gynecology , Etimesgut Military Hospital , Ankara , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozturk
authors.affiliation: b Department of Obstetrics and Gynecology , Gulhane Military Medical Academy , Ankara , Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Keskin
authors.affiliation: c Department of Biochemistry , Gulhane Military Medical Academy , Ankara , Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ozturk
authors.affiliation: b Department of Obstetrics and Gynecology , Gulhane Military Medical Academy , Ankara , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ulubay
authors.affiliation: b Department of Obstetrics and Gynecology , Gulhane Military Medical Academy , Ankara , Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Alanbay
authors.affiliation: a Department of Obstetrics and Gynecology , Etimesgut Military Hospital , Ankara , Turkey.
authors.forename: Aytekin
authors.initials: A
authors.lastname: Aydin
authors.affiliation: b Department of Obstetrics and Gynecology , Gulhane Military Medical Academy , Ankara , Turkey.
authors.forename: Müfit Cemal
authors.initials: MC
authors.lastname: Yenen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis; D015203:Reproducibility of Results; D012107:Research Design; D012680:Sensitivity and Specificity; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D013223:Statistics as Topic; D014421:Turkey; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D002097:C-Reactive Protein; D005723:gamma-Glutamyltransferase; D000075462:Serum Albumin, Human
keywords: Body mass index; PCOS; gamma-glutamyl transferase; high-sensitivity C-reactive protein; ischaemia-modified albumin