title: [Basics of primary immunodeficiencies].
abstract: Primary immunodeficiencies (PID) are a heterogeneous group of inherited disorders, the etiology are the defects in the development or function of the immune system. The principal PID manifestations are the infections in early age, malignancy and diseases of immune dysregulation as autoimmunity and allergy. PIDs are genetics disorders and most of them are inherited as autosomal recessive, also this group of diseases is more prevalent in males and in childhood. The antibody immunodeficiency is the PID more common in adults. The more frequent disorders are the infections in the respiratory tract, abscesses, candidiasis, diarrhea, BCGosis etc. Initial approach included a complete blood count and quantification of immunoglobulins. The delay in diagnosis could be explained due to a perception that the recurrent infections are normal process or think that they are exclusively of childhood. The early diagnosis of PID by primary care physicians is important to opportune treatment and better prognosis.
authors.affiliation: Unidad de Investigación en inmunodeficiencias, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México, México. blancas.lizbeth@gmail.com.
authors.forename: Claudia
authors.initials: C
authors.lastname: Hernández-Martínez
authors.forename: Francisco
authors.initials: F
authors.lastname: Espinosa-Rosales
authors.forename: Sara Elva
authors.initials: SE
authors.lastname: Espinosa-Padilla
authors.forename: Ana Rosa
authors.initials: AR
authors.lastname: Hernández-Martínez
authors.forename: Lizbeth
authors.initials: L
authors.lastname: Blancas-Galicia
mesh_terms: D000328:Adult; D000367:Age Factors; D015551:Autoimmunity / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology*; D007239:Infections / Q000276:immunology; D008297:Male; D012737:Sex Factors
keywords: immunodeficiency diseases; immunoglobulin therapy; primary immunodeficiency; prophylaxis; recurrent infections