title: Synthesis, characterization and biological evaluation of some 5-methylpyrazine carbohydrazide based hydrazones.
abstract: Pyrazine carbohydrazide based hydrazones were synthesized starting from 5-methylpyrazine-2-carboxylic acid. The acid was first converted to its methyl ester, which on further treatment with hydrazine hydrate transformed to carbohydrazide. The carbohydrazide was treated with differently substituted aromatic carbonyl compounds giving hydrazones. Characterization of the synthesized compounds was carried out using modern spectroscopic techniques and unambiguously confirmed through X-ray crystallographic studies of compound 3d. The purity of the compounds was verified using elemental analysis. The target molecules were evaluated for urease inhibition, antioxidant and antimicrobial activity.
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan / Medicinal Botanic Centre, PCSIR Laboratories Complex, Peshawar, Pakistan.
authors.forename: Mushtaq
authors.initials: M
authors.lastname: Ahmad
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan.
authors.forename: Shahid
authors.initials: S
authors.lastname: Hameed
authors.affiliation: Department of Physics, University of Sargodha, Sargodha, Pakistan.
authors.forename: Muhammad Nawaz
authors.initials: MN
authors.lastname: Tahir
authors.affiliation: Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Israr
authors.affiliation: Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Anwar
authors.affiliation: Department of Chemistry, Hazara University, Mansehra, Pakistan.
authors.forename: Muhammad Abdullah Shah Abdullah
authors.initials: MA
authors.lastname: Shah
authors.affiliation: Department of Chemistry, Islamia College University, Peshawar, Pakistan.
authors.forename: Shad Ali
authors.initials: SA
authors.lastname: Khan
authors.affiliation: Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan.
authors.forename: Ghiasud
authors.initials: G
authors.lastname: Din
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D018360:Crystallography, X-Ray; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology*; D013058:Mass Spectrometry; D008958:Models, Molecular; D015394:Molecular Structure; D066244:Proton Magnetic Resonance Spectroscopy; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014510:Urease / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D004791:Enzyme Inhibitors; D006834:Hydrazines; D006835:Hydrazones; D011719:Pyrazines; D014510:Urease; C019289:carbohydrazide