title: Oxidative stress and antioxidant parameters in neutropenic patients secondary to chemotherapy.
abstract: OBJECTIVE
  Neutropenia is a serious adverse event that necessitates dosage reduction in patients receiving chemotherapy. In this study, we evaluated the oxidative stress and antioxidant parameters in neutropenic patients after chemotherapy both during the neutropenic period and after successful treatment of neutropenia with filgrastim.
  
  
  METHODS
  We studied paraoxonase (PON1), arylesterase (ARE), malondialdehyde (MDA), high-density lipoprotein (HDL), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) in addition to routine biochemical and hematologic parameters. SPSS 12.0 was used for statistical evaluation of data (SPSS, Chicago, IL, USA).
  
  
  RESULTS
  In our study, PON1, HDL, and LDH levels during the period of active neutropenia were statistically significantly higher than these levels were after resolution of neutropenia (P<0.05); MDA and ALP levels were statistically significantly lower during the period of active neutropenia (P<0.05).
  
  
  CONCLUSIONS
  Overall, free oxygen radicals (FOR) were increased and antioxidant parameters were decreased with resolution of neutropenia. This is probably due to FOR produced by the increased number of neutrophils rather than tumor burden.
authors.affiliation: Dr. Akif Dogantekin, MD. Department of Internal Medicine, Emek Hospital, Gaziantep, Turkey.
authors.forename: Akif
authors.initials: A
authors.lastname: Dogantekin
authors.affiliation: Dr. Ali Gurel, MD. Mengucek Gazi Training and Research Hospital, Department of Nephrology, Erzincan, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Gurel
authors.affiliation: Prof. Bilal Ustundag, MD. Department of Biochemistry, Firat University Medical School, Elazig, Turkey.
authors.forename: Bilal
authors.initials: B
authors.lastname: Ustundag
authors.affiliation: Selcuk Ilhan, MD. Associate Professor, Department of Pharmacology, Firat University Medical School, Elazig, Turkey.
authors.forename: Selcuk
authors.initials: S
authors.lastname: Ilhan
authors.affiliation: Prof. Emin Tamer Elkiran, MD. Department of Medical Oncology, Inonu University Medical School, Malatya, Turkey.
authors.forename: Emin Tamer
authors.initials: ET
authors.lastname: Elkiran
keywords: Antioxidant; Malondialdehyde; Neutropenia secondary to chemotherapy; Oxidative stress; Paraoxonase