title: Serum homocysteine level and gestational diabetes mellitus: A meta-analysis.
abstract: OBJECTIVE
  Homocysteine levels during pregnancy in women with gestational diabetes mellitus (GDM) have been studied; however, it remains unclear whether hyperhomocysteinemia is a useful predictor of insulin resistance. The present study aimed to evaluate the relationship between homocysteine level and GDM.
  
  
  METHODS
  PubMed, Elsevier, Web of Science and CNKI were searched for relevant studies published up to January 2015. Manual searches of references of the relevant original studies were carried out. Meta-analysis was used to assessed the relationship between homocysteine level and GDM using the stata 12.0 software.
  
  
  RESULTS
  Homocysteine levels were significantly elevated in women with GDM compared with those without GDM (weighted mean difference 0.77, 95% confidence interval 0.44-1.10). This evidence was more consistent during the second trimester measurement of homocysteine (weighted mean difference 0.95, 95% confidence interval 0.67-1.23) and for women aged older than 30 years (weighted mean difference 0.90, 95% confidence interval 0.63-1.17).
  
  
  CONCLUSIONS
  The present meta-analysis shows that homocysteine level is significantly elevated among women with GDM compared with women with normal glucose tolerance, and this finding persists more during the second trimester.
authors.affiliation: Suzhou Maternal and Child Healthcare Institute, Maternal and Child Healthcare Department, Suzhou Municipal Hospital, Affiliated Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Gong
authors.affiliation: Suzhou Maternal and Child Healthcare Institute, Maternal and Child Healthcare Department, Suzhou Municipal Hospital, Affiliated Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Yang
authors.affiliation: Suzhou Maternal and Child Healthcare Institute, Maternal and Child Healthcare Department, Suzhou Municipal Hospital, Affiliated Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Suzhou Maternal and Child Healthcare Institute, Maternal and Child Healthcare Department, Suzhou Municipal Hospital, Affiliated Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: Juning
authors.initials: J
authors.lastname: Liu
authors.affiliation: Suzhou Maternal and Child Healthcare Institute, Maternal and Child Healthcare Department, Suzhou Municipal Hospital, Affiliated Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: Qianlan
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Suzhou Maternal and Child Healthcare Institute, Maternal and Child Healthcare Department, Suzhou Municipal Hospital, Affiliated Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: Qinhua
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Suzhou Maternal and Child Healthcare Institute, Maternal and Child Healthcare Department, Suzhou Municipal Hospital, Affiliated Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: Huiying
authors.initials: H
authors.lastname: Wang
authors.affiliation: Suzhou Maternal and Child Healthcare Institute, Maternal and Child Healthcare Department, Suzhou Municipal Hospital, Affiliated Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: Xiuyu
authors.initials: X
authors.lastname: He
authors.affiliation: Suzhou Maternal and Child Healthcare Institute, Maternal and Child Healthcare Department, Suzhou Municipal Hospital, Affiliated Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: Yunzhen
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Suzhou Maternal and Child Healthcare Institute, Maternal and Child Healthcare Department, Suzhou Municipal Hospital, Affiliated Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Xu
authors.affiliation: Suzhou Maternal and Child Healthcare Institute, Maternal and Child Healthcare Department, Suzhou Municipal Hospital, Affiliated Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D011247:Pregnancy
chemical_list: D006710:Homocysteine
keywords: Gestational diabetes mellitus; Homocysteine; Hyperhomocysteinemia