title: Paraneoplastic Progressive Vasculopathy as the Presenting Manifestation of Polyneuropathy, Organomegaly, Endocrinopathy or Edema, M-Spike, and Skin Manifestations: A Case Report.
abstract: Polyneuropathy, organomegaly, endocrinopathy or edema, M-spike, and skin manifestations (POEMS) syndrome is a rare multisystem disease. There are very few reports of stroke as the presenting manifestation of POEMS. We report a patient with ischemic stroke due to an underlying vasculopathy as the initial presentation of POEMS. This case highlights the importance of recognizing ischemic stroke as a presenting sign for POEMS as early diagnosis and treatment in patients with POEMS may prevent progression of multisystem involvement and may potentially stabilize the vasculopathy associated with it.
authors.affiliation: Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address: shadiyaghi@yahoo.com.
authors.forename: Shadi
authors.initials: S
authors.lastname: Yaghi
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York; Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, New York.
authors.forename: Mitchell S V
authors.initials: MSV
authors.lastname: Elkind
mesh_terms: D000328:Adult; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D002533:Cerebral Angiography / Q000379:methods; D057210:Delayed Diagnosis; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D016878:POEMS Syndrome / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D020521:Stroke / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D013997:Time Factors
keywords: POEMS; diagnosis; ischemic stroke; vasculopathy