title: Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne.
abstract: BACKGROUND
  Acne vulgaris is the most common skin disease. Local and systemic antimicrobial drugs are used for its treatment. But increasing resistance of Propionibacterium acnes to antibiotics has been reported.
  
  
  METHODS
  In a double-blind clinical trial, 40 patients with mild to moderate acne vulgaris were recruited. one side of the face was treated with Clindamycin Gel 1% and the other side with Azithromycin Topical Gel 2% BID for 8 weeks and then they were assessed.
  
  
  RESULTS
  Average age was 21. 8 ± 7 years. 82.5% of them were female. Average number of papules, pustules and comedones was similarly reduced in both groups and, no significant difference was observed between the two groups (P > 0.05, repeated measurs ANOVA). The mean indexes of ASI and TLC also significantly decreased during treatment in both groups, no significant difference was observed between the two groups. (P > 0.05, repeated measurs ANOVA). Also, impact of both drugs on papules and pustules was 2-3 times greater than the effect on comedones. Average satisfaction score was not significant between the two groups (P = 0.6, repeated measurs ANOVA). finally, frequency distribution of complications was not significant between the two groups (P > 0.05, Fisher Exact test).
  
  
  CONCLUSIONS
  Azithromycin gel has medical impact at least similar to Clindamycin Gel in treatment of mild to moderate acne vulgaris, and it may be consider as suitable drug for resistant acne to conventional topical therapy.
authors.affiliation: Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mokhtari
authors.affiliation: Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan, Iran.
authors.forename: Gita
authors.initials: G
authors.lastname: Faghihi
authors.affiliation: Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Akram
authors.initials: A
authors.lastname: Basiri
authors.affiliation: Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Sadaf
authors.initials: S
authors.lastname: Farhadi
authors.affiliation: Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan, Iran.
authors.forename: Mohammadali
authors.initials: M
authors.lastname: Nilforoushzadeh
authors.affiliation: Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Shadi
authors.initials: S
authors.lastname: Behfar
keywords: Acne vulgaris; administration topical drug; azithromycin; clindamycin; drug treatment