title: Simple and Procedural Reaction Time for Mild Traumatic Brain Injury in a Hyperbaric Oxygen Clinical Trial.
abstract: Simple reaction time (SRT) and procedural reaction time (PRT) are speed-of-processing tasks in the Automated Neuropsychological Assessment Metrics (ANAM) that may be sensitive to mild traumatic brain injury (mTBI). The investigators measured SRT and PRT throughput (correct responses per minute) at baseline, 6 weeks, and 13 weeks in military personnel with mTBI randomized to local care or 40 chamber sessions (sham-1.2 atmospheres absolute [ATA] air, hyperbaric oxygen-1.5 ATA O2). Scores were assessed at baseline using univariate analysis of variance and across time with repeated measures methods. Data reported as throughput standard scores (mean = 100, SD = 15). Seventy-two participants with ongoing symptoms after mTBI enrolled in the study (three female, median age 31 years, mean three lifetime concussion events, most recent mTBI 23 months prior). Sixty-four had Automated Neuropsychological Assessment Metrics data at 13 weeks. SRT and PRT throughput standard scores were comparable across groups at baseline. Over time, SRT scores did not change in the hyperbaric oxygen or sham groups and decreased in the local care group. PRT throughput standard scores increased from baseline to mid-intervention and decreased from mid-intervention to postintervention in all groups. Repeated measures change over time in SRT (p = 0.23), and PRT (p = 0.17) scores were not different among groups. This study may be underpowered to detect statistically significant change.
authors.affiliation: Division of Hyperbaric Medicine, LDS Hospital, 8th Avenue & C Street, Salt Lake City, UT 84143.
authors.forename: Susan
authors.initials: S
authors.lastname: Churchill
authors.affiliation: Uniformed Services University of Health Sciences, 11803 Prestwick Road, Potomac, MD 20854.
authors.forename: R Scott
authors.initials: RS
authors.lastname: Miller
authors.affiliation: Division of Hyperbaric Medicine, LDS Hospital, 8th Avenue & C Street, Salt Lake City, UT 84143.
authors.forename: Kayla
authors.initials: K
authors.lastname: Deru
authors.affiliation: The Emmes Corporation, 401 North Washington Street, Suite 700, Rockville, MD 20850.
authors.forename: Steffanie H
authors.initials: SH
authors.lastname: Wilson
authors.affiliation: Division of Hyperbaric Medicine, LDS Hospital, 8th Avenue & C Street, Salt Lake City, UT 84143.
authors.forename: Lindell K
authors.initials: LK
authors.lastname: Weaver
mesh_terms: D000328:Adult; D001924:Brain Concussion / Q000145:classification / Q000150:complications / Q000628:therapy*; D001930:Brain Injuries / Q000523:psychology / Q000628:therapy; D060825:Cognitive Dysfunction; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008889:Military Personnel / Q000523:psychology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000627:therapeutic use; D011930:Reaction Time
chemical_list: D010100:Oxygen