title: Shaping Nanoparticles with Hydrophilic Compositions and Hydrophobic Properties as Nanocarriers for Antibiotic Delivery.
abstract: Inspired by the lotus effect in nature, surface roughness engineering has led to novel materials and applications in many fields. Despite the rapid progress in superhydrophobic and superoleophobic materials, this concept of Mother Nature's choice is yet to be applied in the design of advanced nanocarriers for drug delivery. Pioneering work has emerged in the development of nanoparticles with rough surfaces for gene delivery; however, the preparation of nanoparticles with hydrophilic compositions but with enhanced hydrophobic property at the nanoscale level employing surface topology engineering remains a challenge. Herein we report for the first time the unique properties of mesoporous hollow silica (MHS) nanospheres with controlled surface roughness. Compared to MHS with a smooth surface, rough mesoporous hollow silica (RMHS) nanoparticles with the same hydrophilic composition show unusual hydrophobicity, leading to higher adsorption of a range of hydrophobic molecules and controlled release of hydrophilic molecules. RMHS loaded with vancomycin exhibits an enhanced antibacterial effect. Our strategy provides a new pathway in the design of novel nanocarriers for diverse bioapplications.
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , Brisbane, Queensland 4072, Australia.
authors.forename: Yusilawati
authors.initials: Y
authors.lastname: Ahmad Nor
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , Brisbane, Queensland 4072, Australia.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Niu
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , Brisbane, Queensland 4072, Australia.
authors.forename: Surajit
authors.initials: S
authors.lastname: Karmakar
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , Brisbane, Queensland 4072, Australia.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , Brisbane, Queensland 4072, Australia.
authors.forename: Chun
authors.initials: C
authors.lastname: Xu
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , Brisbane, Queensland 4072, Australia.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , Brisbane, Queensland 4072, Australia.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , Brisbane, Queensland 4072, Australia.
authors.forename: Meihua
authors.initials: M
authors.lastname: Yu
authors.affiliation: Queensland Alliance for Agriculture and Food Innovation, The University of Queensland , Brisbane, Queensland 4072, Australia.
authors.forename: Donna
authors.initials: D
authors.lastname: Mahony
authors.affiliation: Queensland Alliance for Agriculture and Food Innovation, The University of Queensland , Brisbane, Queensland 4072, Australia.
authors.forename: Neena
authors.initials: N
authors.lastname: Mitter
authors.affiliation: Institute for Molecular Bioscience, The University of Queensland , Brisbane, Queensland 4072, Australia.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Cooper
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , Brisbane, Queensland 4072, Australia.
authors.forename: Chengzhong
authors.initials: C
authors.lastname: Yu