title: Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats.
abstract: The present study aimed to investigate the therapeutic efficacy of post-inflammatory treatment with luteolin on endotoxin-induced uveitis (EIU) in rats. Intraperitoneal injection of 10 mg/kg luteolin or 1 mg/kg prednisolone (Pred) at 4 hr post-lipopolysaccharide (LPS) injection (200 µg) was associated at 24 hr post-LPS injection with decreased clinical severity scores, number of inflammatory cells, protein levels and levels of tumor necrosis factor (TNF)-α, nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor (AqH) and degrees of histological ocular tissue injury. The anti-inflammatory potency of luteolin was comparable to that of Pred. Luteolin exhibited robust efficacy in the treatment of EIU in rats, indicating its potential clinical utility in treating uveitis.
authors.affiliation: Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, Towada, Aomori 034-8628, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Kanai
authors.forename: Sho
authors.initials: S
authors.lastname: Nagata
authors.forename: Takuya
authors.initials: T
authors.lastname: Hatta
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sugiura
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Sato
authors.forename: Yohei
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Yuya
authors.initials: Y
authors.lastname: Kimura
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Itoh
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001082:Aqueous Humor / Q000737:chemistry; D015232:Dinoprostone / Q000032:analysis; D004195:Disease Models, Animal; D004731:Endotoxins / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy; D047311:Luteolin / Q000627:therapeutic use*; D008297:Male; D009569:Nitric Oxide / Q000032:analysis; D051381:Rats; D011917:Rats, Inbred Lew; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D014605:Uveitis / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D004731:Endotoxins; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D015232:Dinoprostone; D047311:Luteolin