title: Myocardial Fibrosis in Congenital Heart Disease.
abstract: Myocardial fibrosis is common in patients with congenital heart disease (CHD) and has been associated with arrhythmias, decreased functional status, and adverse ventricular mechanics. There are multiple types of myocardial fibrosis that occur in response to different pathophysiologic stimuli. Recent advances in imaging technology have made detection and quantification of the types of myocardial fibrosis possible. In this review, we describe the pathophysiology of myocardial fibrosis, examine the imaging techniques used to evaluate fibrosis, and discuss the relationship between myocardial fibrosis and clinical outcomes in CHD. (Circ J 2016; 80: 1300-1307).
authors.affiliation: Department of Cardiology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School.
authors.forename: Rahul H
authors.initials: RH
authors.lastname: Rathod
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Powell
authors.forename: Tal
authors.initials: T
authors.lastname: Geva
mesh_terms: D057791:Cardiac Imaging Techniques; D005355:Fibrosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006330:Heart Defects, Congenital / Q000473:pathology*; D006801:Humans; D009206:Myocardium / Q000473:pathology*; D016896:Treatment Outcome