title: TBC1D14 sets the TRAPP for ATG9.
abstract: Amino acid withdrawal induces the formation of autophagosomes, which results in dozens of these large double-membrane vesicles appearing in the starved cell within 10-15 min, and the initiation of autophagy. This vesicle-mediated response clearly requires an adequate supply of membrane and a tight molecular regulation creating a substantial challenge for the cell in terms of vesicle trafficking pathways. Several membrane sources, which contribute to autophagosome initiation and formation, have been identified including the ER, Golgi, plasma membrane, mitochondria and recycling endosomes. How contributions from these organelles are regulated is an intensive area of study. Members of several families of membrane traffic regulators, including small GTPases, such as RAB proteins, and their regulators, SNARE proteins and BAR domain-containing proteins, have recently been shown to support autophagosome formation.
authors.affiliation: a The Francis Crick Institute, Molecular Cell Biology of Autophagy, Lincoln's Inn Fields Laboratories , London , UK.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Lamb
authors.affiliation: a The Francis Crick Institute, Molecular Cell Biology of Autophagy, Lincoln's Inn Fields Laboratories , London , UK.
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Tooze
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D011992:Endosomes / Q000378:metabolism; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D033921:Vesicular Transport Proteins / Q000378:metabolism*
chemical_list: D020690:GTPase-Activating Proteins; C574472:TBC1D14 protein, human; D033921:Vesicular Transport Proteins; C406327:transport protein particle, TRAPP
keywords: ATG9; RAB protein; TBC1D14; TRAPP; autophagy; endosome; golgi