title: Facilitated subcutaneous immunoglobulin administration (fSCIg): a new treatment option for patients with secondary immune deficiencies.
abstract: The number of patients with secondary immune deficiencies (SID) is on the rise, mostly since the arrival on the market of novel targeted therapies that have increased the survival rates of patients with hematological malignancies. The recent changes in the SID landscape have brought with them new and diverse medical needs that treatments for SID management should strive to meet. In this special report, we study the opportunities provided by facilitated subcutaneous immunoglobulin administration (fSCIg) to treat patients for whom the conventional routes (intravenous and subcutaneous) are sub-optimal. Experts in the treatment of SID describe real-life cases from their daily practice, in which fSCIg has led to reducing the burden of treatment and increasing the treatment satisfaction.
authors.affiliation: a Medizinische Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie , Charité - Universitätsmedizin , Berlin , Germany.
authors.forename: Igor-Wolfgang
authors.initials: IW
authors.lastname: Blau
authors.affiliation: b Department of Immunology , St. James's Hospital , Dublin , Ireland.
authors.forename: Niall
authors.initials: N
authors.lastname: Conlon
authors.affiliation: c Baxalta Innovations GmbH , Vienna , Austria.
authors.forename: Robert
authors.initials: R
authors.lastname: Petermann
authors.affiliation: d Baxalta GmbH , Zurich , Switzerland.
authors.forename: Nikolai
authors.initials: N
authors.lastname: Nikolov
authors.affiliation: e Vejle Hospital , Vejle , Denmark.
authors.forename: Torben
authors.initials: T
authors.lastname: Plesner
mesh_terms: D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications / Q000276:immunology / Q000628:therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D007239:Infections / Q000150:complications / Q000276:immunology / Q000628:therapy*; D055104:Infusions, Subcutaneous; D008297:Male; D057285:Precision Medicine
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: IVIG; SCIG; Secondary immune deficiencies; fSCIG; hyaluronidase; immunoglobulin replacement; individualized therapy