title: Preserving Brain Function in Aging: The Anti-glycative Potential of Berry Fruit.
abstract: Advanced glycation end products (AGEs) are naturally occurring macromolecules that are formed in vivo by the non-enzymatic modification of proteins, lipids, or nucleic acids by sugar, even in the absence of hyperglycemia. In the diet, AGEs are found in animal products, and additional AGEs are produced when those foods are cooked at high temperatures. Studies have linked AGEs to various age-related physiological changes, including wrinkles, diabetic complications, and neurodegenerative disease, including Alzheimer's disease. Dietary berry fruits have been shown to reduce the severity or slow the progression of many physiological changes and disease pathologies that accompany aging. Emerging evidence has shown that the phytochemicals found in berry fruits exhibit anti-glycative activity. In this review, we briefly summarize the current evidence supporting the neuroprotective anti-glycative activity of berry fruits and their potential to preserve cognitive function during aging.
authors.affiliation: USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA.
authors.forename: Nopporn
authors.initials: N
authors.lastname: Thangthaeng
authors.affiliation: USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA.
authors.forename: Shibu M
authors.initials: SM
authors.lastname: Poulose
authors.affiliation: USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA.
authors.forename: Marshall G
authors.initials: MG
authors.lastname: Miller
authors.affiliation: USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA. barbara.shukitthale@ars.usda.gov.
authors.forename: Barbara
authors.initials: B
authors.lastname: Shukitt-Hale
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000517:prevention & control; D000818:Animals; D001921:Brain / Q000502:physiology*; D004032:Diet; D005638:Fruit / Q000737:chemistry / Q000378:metabolism*; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors; D006801:Humans; D019636:Neurodegenerative Diseases / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000737:chemistry
chemical_list: D017127:Glycation End Products, Advanced; D018696:Neuroprotective Agents
keywords: AGEs; Advanced glycation end products; Aging; Berry; Cognition; Glycation