title: Indocyanine green retention test (ICG-r15) as a noninvasive predictor of portal hypertension in patients with different severity of cirrhosis.
abstract: OBJECTIVE
  Portal hypertension is a severe consequence of chronic liver disease, responsible for the main clinical complications of cirrhosis. Measurement of the hepatic venous pressure gradient (HVPG) provides important clinical information, but the procedure is invasive and demands expert skills of the staff.In the present study, we aimed to investigate the relationship between the constant infusion indocyanine green (ICG) clearance, the calculated ICG retention test after 15 min (ICG-r15), and HVPG in patients with different severity of cirrhosis for validation of ICG-r15 as a noninvasive predictor of portal hypertension.
  
  
  METHODS
  A total of 325 patients were studied. During a hemodynamic investigation, the ICG clearance was determined using the constant infusion technique and ICG-r15 was calculated.
  
  
  RESULTS
  Assessment of the diagnostic performance of ICG clearance and ICG-r15 as predictors of HVPG above 10 mmHg was performed by receiver operating characteristic curve analyses.The ICG clearance and ICG-r15 performed well in all three Child classes, with the most significant results among Child class A patients [area under the receiver operating characteristic (AUROC)=0.832] and less significant results in Child class B (AUROC=0.7448) and Child class C patients (AUROC=0.7392). Only six out of 102 patients in Child class C had HVPG of less than 12 mmHg.
  
  
  CONCLUSIONS
  ICG-r15 can be used as an indirect assessment of significant portal hypertension in compensated cirrhotic patients. ICG-r15 may be suitable as a screening tool for the identification of patients for endoscopy and measurement of HVPG.Further validation of ICG-r15 together with other predictors of portal hypertension and its clinical use is encouraged.
authors.affiliation: aDepartment of Gastroenterology, Medical Division 360, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen bDepartment of Orthopedic Surgery, Clinical Research Centre, Copenhagen University Hospital Hvidovre cDepartment of Clinical Physiology and Nuclear Medicine 260, Center of Functional and Diagnostic Imaging and Research, Hvidovre, Denmark.
authors.forename: Marie-Louise L
authors.initials: ML
authors.lastname: Pind
authors.forename: Flemming
authors.initials: F
authors.lastname: Bendtsen
authors.forename: Thomas
authors.initials: T
authors.lastname: Kallemose
authors.forename: Søren
authors.initials: S
authors.lastname: Møller
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D018450:Disease Progression; D005260:Female; D005456:Fluorescent Dyes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D065669:Hepatobiliary Elimination; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D007208:Indocyanine Green / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007262:Infusions, Intravenous; D008099:Liver / Q000098:blood supply* / Q000378:metabolism*; D008102:Liver Circulation; D008103:Liver Cirrhosis / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D017082:Portal Pressure; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D015203:Reproducibility of Results; D012720:Severity of Illness Index
chemical_list: D005456:Fluorescent Dyes; D007208:Indocyanine Green