title: Cingulate Cortical Thickness and Dopamine Transporter ( DAT1) Genotype in Children and Adolescents With ADHD.
abstract: This study aimed to examine the influence of dopamine transporter gene ( DAT1) 3'UTR genotype on cingulate cortical thickness in a large sample of children and adolescents with ADHD.
  
  
  
  Brain MRIs were acquired from 46 ADHD patients with homozygosity for the 10-repeat allele and 52 ADHD patients with a single copy or no copy of the allele. The cingulate cortex of each MRI scan was automatically parceled into sulci and gyri as well as into Brodmann areas (BA).
  
  
  
  There were no group differences in age, gender, full-scale intelligence quotient, symptom severity, treatment status, comorbidity, or mean overall cortical thickness. Sulcus/gyrus- and BA-based analyses revealed that patients homozygous for the 10-repeat allele showed significantly greater thickness in right cingulate gyrus and right BA 24 compared with 9-repeat carriers.
  
  
  
  These findings suggest that thickness of cingulate cortex is influenced by the presence of the 10-repeat allele in ADHD.
authors.affiliation: 1 Hospital Universitario Quirón, Madrid, Spain.|2 CADE, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernández-Jaén
authors.affiliation: 3 Universidad Autónoma de Madrid, Spain.
authors.forename: Jacobo
authors.initials: J
authors.lastname: Albert
authors.affiliation: 1 Hospital Universitario Quirón, Madrid, Spain.|2 CADE, Madrid, Spain.
authors.forename: Daniel Martín
authors.initials: DM
authors.lastname: Fernández-Mayoralas
authors.affiliation: 4 Univesidad Rey Juan Carlos, Madrid, Spain.|5 Centro Neuromottiva, Madrid, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: López-Martín
authors.affiliation: 1 Hospital Universitario Quirón, Madrid, Spain.
authors.forename: Ana Laura
authors.initials: AL
authors.lastname: Fernández-Perrone
authors.affiliation: 1 Hospital Universitario Quirón, Madrid, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Jimenez de la Peña
authors.affiliation: 6 Centro de Salud Doctor Cirajas, Madrid, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Calleja-Pérez
authors.affiliation: 1 Hospital Universitario Quirón, Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Recio Rodríguez
authors.affiliation: 7 Hospital Gómez Ulla, Madrid, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: López Arribas
mesh_terms: D000293:Adolescent; D000483:Alleles; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D002648:Child; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D006179:Gyrus Cinguli / Q000473:pathology*; D006720:Homozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; C493214:SLC6A3 protein, human
keywords: ADHD; DAT1; cingulate cortex; cortical thickness