title: Switching to instant black coffee modulates sodium selenite-induced cataract in rats.
abstract: The influence of daily consumption of some common beverages on the development of cataract in rats was investigated. Total phenol content was determined in the beverages and an oral standardized dose of total phenols from each beverage was given to the treated rats. Weaned male albino rats were used and divided into five groups (n=7). Rats were fed Ain 93G and administered the standardized dose of instant coffee, black tea and hibiscus beverages for 30 days. On day 14 all rats were injected with a single dose of sodium selenite (Na2SeO3) 15 µmol/kg bodyweight, except the control groups NC (negative control, did not receive Na2SeO3) and PC (positive control, was already injected on day 1 of the study). The rats were continued on Ain 93G and the standardized dose for another 16 days. Positive control rats were used. Total phenols were 210, 40, and 44 mg/g dry weight gallic acid equivalent in black coffee, black tea, and hibiscus, respectively. Decreased levels (statistically significant P<0.05) of malondialdehyde, total nitric oxide, Ca-ATPase, tumor necrosis factor-α, interleukin-1β, superoxide dismutase, and conversely, increased levels (statistically significant P<0.05) of total protein, reduced glutathione, catalase were found in the lenses of the coffee group compared to PC. There are co-phenol substances in the instant black coffee that promoted coffee to be the most effective beverage.
authors.affiliation: Department of Home Economics, Women's College, Ain Shams University, Cairo, Egypt.
authors.forename: E A
authors.initials: EA
authors.lastname: El Okda
authors.affiliation: Department of Home Economics, Women's College, Ain Shams University, Cairo, Egypt.
authors.forename: M M
authors.initials: MM
authors.lastname: Mohamed
authors.affiliation: Pathology Department, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt.
authors.forename: E B
authors.initials: EB
authors.lastname: Shaheed
authors.affiliation: Department of Nutrition and Food Science, Faculty of Home Economics, Helwan University, Cairo, Egypt.
authors.forename: A R
authors.initials: AR
authors.lastname: Abdel-Moemin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002386:Cataract / Q000139:chemically induced / Q000473:pathology* / Q000517:prevention & control*; D003069:Coffee / Q000737:chemistry*; D008297:Male; D010636:Phenols / Q000008:administration & dosage*; D010936:Plant Extracts / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D018038:Sodium Selenite; D013662:Tea / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D003069:Coffee; D010636:Phenols; D010936:Plant Extracts; D013662:Tea; D018038:Sodium Selenite
keywords: black tea; cataract; co-phenols; hibiscus; instant black coffee; rats; sodium selenite; total phenols