title: Chemical Exchange Saturation Transfer MR Imaging: Potential Clinical Applications.
abstract: Chemical exchange saturation transfer (CEST) measurements hold great promise as the next step in magnetization transfer imaging and possibly allow for in vivo quantification of many clinically relevant parameters, including pH, temperature, and amide concentration. Therefore, it is a valuable method to add to the MR imaging toolbox. The aim of this article was to review the methods for the acquisition of CEST data and necessary postprocessing. CEST research is very much a field still in development, and initial explorations in clinical applications are shown to illustrate the potential of CEST as a new contrast mechanism.
authors.affiliation: Imaging Division, Department of Radiology, UMCU, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
authors.forename: Daniel Louis
authors.initials: DL
authors.lastname: Polders
authors.affiliation: Imaging Division, Department of Radiology, UMCU, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands; Brain Division, UMCU, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. Electronic address: j.m.hoogduin-2@umcutrecht.nl.
authors.forename: Johannes Marinus
authors.initials: JM
authors.lastname: Hoogduin