title: Role of L1CAM in the Regulation of the Canonical Wnt Pathway and Class I MAGE Genes.
abstract: Molecule L1CAM is specific for nerve cells and tumors of various localizations. The expression of L1CAM is significantly higher in melanoma in comparison with benign nevi and correlates with the progress of melanoma and transition from radial to vertical growth. Monoclonal antibodies to L1CAM effectively and specifically attenuate melanoma growth, though stimulates the epithelial-mesenchymal transition. shRNA-mediated knock-down of L1CAM showed the involvement of L1CAM in regulation of activity of the canonical Wnt pathway and expression of genes of class I melanoma-associated antigens (MAGE).
authors.affiliation: National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia. mshkurnikov@imscs.msu.ru.
authors.forename: M Yu
authors.initials: MY
authors.lastname: Shkurnikov
authors.affiliation: National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: E N
authors.initials: EN
authors.lastname: Knyazev
authors.affiliation: University Medical-Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Wicklein
authors.affiliation: University Medical-Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Schumacher
authors.affiliation: Moscow State University of Mechanical Engineering (MAMI), Moscow, Russia.
authors.forename: T R
authors.initials: TR
authors.lastname: Samatov
authors.affiliation: National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Tonevitskii
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008545:Melanoma / Q000235:genetics / Q000378:metabolism; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D039842:Neural Cell Adhesion Molecule L1 / Q000502:physiology*; D060449:Wnt Signaling Pathway
chemical_list: D000951:Antigens, Neoplasm; C110905:MAGEC1 protein, human; C405429:MAGEC2 protein, human; D009363:Neoplasm Proteins; D039842:Neural Cell Adhesion Molecule L1
keywords: L1CAM; MAGE; Wnt; melanoma; shRNA