title: [Self-rated Caffeine Sensitivity: Implications for Personalized Sleep Medicine?].
abstract: The prevalence of the insomnia syndrome and the effects of caffeine on sleep are in part genetically determined. Pharmacogenetic studies in humans demonstrate that functional polymorphisms of the genes encoding adenosine A2A receptors and dopamine transporters contribute to individual differences in impaired sleep quality by caffeine. The A2A receptor and dopamine transporter are preferentially expressed in the striatum. Together, these observations suggest that the striatum plays an important role in sleep-wake regulation. Individual caffeine sensitivity and A2A receptor genotype should be taken into account in the development of possible novel adenosine-based pharmacotherapies of sleep-wake disorders and neurodegenerative disorders such as Parkinson's disease. This may permit the prediction of individual drug effects and improve the reliability of clinical trials.
authors.affiliation: 1 Institut für Pharmakologie und Toxikologie, Universität Zürich.|2 Klinischer Forschungsschwerpunkt Sleep & Health, Universität Zürich.|3 Zürcher Zentrum für interdisziplinäre Schlafforschung (ZiS), Universität Zürich.
authors.forename: Hans Peter
authors.initials: HP
authors.lastname: Landolt
mesh_terms: D000483:Alleles; D002110:Caffeine / Q000009:adverse effects*; D003342:Corpus Striatum / Q000503:physiopathology; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics; D057285:Precision Medicine / Q000379:methods*; D043705:Receptor, Adenosine A2A / Q000235:genetics*; D020178:Sleep Disorders, Circadian Rhythm / Q000235:genetics / Q000503:physiopathology; D007319:Sleep Initiation and Maintenance Disorders / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D056508:Sleep Medicine Specialty
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D043705:Receptor, Adenosine A2A; D002110:Caffeine
keywords: Adenosin; Dopamin; Insomnie; Pharmakogenetik; Striatum; adenosine; adénosine; dopamine; insomnia; insomnie; pharmacogenetics; pharmacogénétique; striatum