title: The Potential Protective Effects of Polyphenols in Asbestos-Mediated Inflammation and Carcinogenesis of Mesothelium.
abstract: Malignant Mesothelioma (MM) is a tumor of the serous membranes linked to exposure to asbestos. A chronic inflammatory response orchestrated by mesothelial cells contributes to the development and progression of MM. The evidence that: (a) multiple signaling pathways are aberrantly activated in MM cells; (b) asbestos mediated-chronic inflammation has a key role in MM carcinogenesis; (c) the deregulation of the immune system might favor the development of MM; and (d) a drug might have a better efficacy when injected into a serous cavity thus bypassing biotransformation and reaching an effective dose has prompted investigations to evaluate the effects of polyphenols for the therapy and prevention of MM. Dietary polyphenols are able to inhibit cancer cell growth by targeting multiple signaling pathways, reducing inflammation, and modulating immune response. The ability of polyphenols to modulate the production of pro-inflammatory molecules by targeting signaling pathways or ROS might represent a key mechanism to prevent and/or to contrast the development of MM. In this review, we will report the current knowledge on the ability of polyphenols to modulate the immune system and production of mediators of inflammation, thus revealing an important tool in preventing and/or counteracting the growth of MM.
authors.affiliation: Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome 00133, Italy. monicab4@hotmail.it.
authors.forename: Monica
authors.initials: M
authors.lastname: Benvenuto
authors.affiliation: Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome 00133, Italy. rosannamatter@gmail.com.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Mattera
authors.affiliation: Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome 00133, Italy. g.taffera@gmail.com.
authors.forename: Gloria
authors.initials: G
authors.lastname: Taffera
authors.affiliation: Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome 00133, Italy. giganti@med.uniroma2.it.
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Giganti
authors.affiliation: Internal Medicine Residency Program, University of Rome "Tor Vergata", Rome 00133, Italy. paulshore@virgilio.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Lido
authors.affiliation: Department of Experimental Medicine, University of Rome "Sapienza", Rome 00164, Italy. Laura.masuelli@uniroma1.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Masuelli
authors.affiliation: Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome 00133, Italy. modesti@med.uniroma2.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Modesti
authors.affiliation: Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome 00133, Italy. bei@med.uniroma2.it.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bei
mesh_terms: D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D063646:Carcinogenesis / Q000187:drug effects*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced* / Q000517:prevention & control*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D008654:Mesothelioma / Q000139:chemically induced / Q000517:prevention & control*; D000086002:Mesothelioma, Malignant; D059808:Polyphenols / Q000494:pharmacology*
chemical_list: D059808:Polyphenols; D001194:Asbestos
keywords: ROS and RNS; asbestos; immune system; inflammation; malignant mesothelioma; polyphenols