title: Methylphenidate for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents.
abstract: OBJECTIVE
  Is treatment with methylphenidate associated with benefits or harms for children and adolescents with attention-deficit/hyperactivity disorder (ADHD)?
  
  
  CONCLUSIONS
  Methylphenidate is associated with improvement in ADHD symptoms, general behavior, and quality of life; however, due to the very low quality of the evidence, the magnitude of the associated improvement is uncertain. Methylphenidate was associated with an increased risk of nonserious adverse events. There are too few data to assess the association with serious adverse events.
authors.affiliation: Psychiatric Research Unit, Child and Adolescent Psychiatric Department, Region Zealand Psychiatry, Region Zealand, Denmark.
authors.forename: Ole J
authors.initials: OJ
authors.lastname: Storebø
authors.affiliation: Psychiatric Research Unit, Region Zealand Psychiatry, Region Zealand, Denmark.
authors.forename: Erik
authors.initials: E
authors.lastname: Simonsen
authors.affiliation: Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Christian
authors.initials: C
authors.lastname: Gluud
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate