title: Chemical Leukoderma.
abstract: Chemical leukoderma, often clinically mimicking idiopathic vitiligo and other congenital and acquired hypopigmentation, is an acquired form of cutaneous pigment loss caused by exposure to a variety of chemicals that act through selective melanocytotoxicity. Most of these chemicals are phenols and aromatic or aliphatic catechols derivatives. These chemicals, however, are harmful for melanocytes in individuals with an individual susceptibility. Nowadays, chemical leukoderma is fairly common, caused by common domestic products. The presence of numerous acquired confetti- or pea-sized macules is clinically characteristic of chemical leukoderma, albeit not diagnostic. Other relevant diagnostic elements are a history of repeated exposure to a known or suspected depigmenting agent at the sites of onset and a macules distribution corresponding to sites of chemical exposure. Spontaneous repigmentation has been reported when the causative agent is avoided; the repigmentation process is perifollicular and gradual, taking place for a variable period of weeks to months.
authors.affiliation: From the Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Bonamonte
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Vestita
authors.forename: Paolo
authors.initials: P
authors.lastname: Romita
authors.forename: Angela
authors.initials: A
authors.lastname: Filoni
authors.forename: Caterina
authors.initials: C
authors.lastname: Foti
authors.forename: Gianni
authors.initials: G
authors.lastname: Angelini
mesh_terms: D003877:Dermatitis, Contact; D009783:Dermatitis, Occupational; D006229:Hand Dermatoses; D006801:Humans; D017496:Hypopigmentation