title: Gastric Cancer: How Can We Reduce the Incidence of this Disease?
abstract: Gastric cancer remains a prevalent disease worldwide with a poor prognosis. Helicobacter pylori plays a major role in gastric carcinogenesis. H. pylori colonization leads to chronic gastritis, which predisposes to atrophic gastritis, intestinal metaplasia, dysplasia, and eventually gastric cancer. Screening, treatment, and prevention of H. pylori colonization can reduce the incidence of gastric cancer. Other interventions that may yield a similar effect, although of smaller magnitude, include promotion of a healthy lifestyle including dietary measures, non-smoking, low alcohol intake, and sufficient physical activity. This chapter reviews interventions that can lead to a decline in gastric cancer incidence in high and low incidence countries.
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. c.denhoed@erasmusmc.nl.
authors.forename: Caroline M
authors.initials: CM
authors.lastname: den Hoed
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Kuipers
mesh_terms: D004032:Diet; D016481:Helicobacter Infections / Q000150:complications / Q000628:therapy; D016480:Helicobacter pylori; D006801:Humans; D015994:Incidence; D008019:Life Style; D011230:Precancerous Conditions / Q000175:diagnosis; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control*
keywords: Diet; Epidemiology; Gastric cancer; Helicobacter pylori; Prevention; Screening