title: Symmetric spike timing-dependent plasticity at CA3-CA3 synapses optimizes storage and recall in autoassociative networks.
abstract: CA3-CA3 recurrent excitatory synapses are thought to play a key role in memory storage and pattern completion. Whether the plasticity properties of these synapses are consistent with their proposed network functions remains unclear. Here, we examine the properties of spike timing-dependent plasticity (STDP) at CA3-CA3 synapses. Low-frequency pairing of excitatory postsynaptic potentials (EPSPs) and action potentials (APs) induces long-term potentiation (LTP), independent of temporal order. The STDP curve is symmetric and broad (half-width ∼150 ms). Consistent with these STDP induction properties, AP-EPSP sequences lead to supralinear summation of spine [Ca(2+)] transients. Furthermore, afterdepolarizations (ADPs) following APs efficiently propagate into dendrites of CA3 pyramidal neurons, and EPSPs summate with dendritic ADPs. In autoassociative network models, storage and recall are more robust with symmetric than with asymmetric STDP rules. Thus, a specialized STDP induction rule allows reliable storage and recall of information in the hippocampal CA3 network.
authors.affiliation: Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, A-3400, Austria.
authors.forename: Rajiv K
authors.initials: RK
authors.lastname: Mishra
authors.affiliation: Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, A-3400, Austria.
authors.forename: Sooyun
authors.initials: S
authors.lastname: Kim
authors.affiliation: Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, A-3400, Austria.
authors.forename: Segundo J
authors.initials: SJ
authors.lastname: Guzman
authors.affiliation: Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg, A-3400, Austria.
authors.forename: Peter
authors.initials: P
authors.lastname: Jonas
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D056654:CA3 Region, Hippocampal / Q000166:cytology / Q000502:physiology*; D002118:Calcium / Q000737:chemistry / Q000378:metabolism; D003712:Dendrites / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D005260:Female; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D023421:Models, Animal; D057054:Molecular Imaging / Q000379:methods; D009415:Nerve Net / Q000502:physiology*; D061848:Optical Imaging / Q000379:methods; D017966:Pyramidal Cells / Q000166:cytology / Q000502:physiology; D051381:Rats; D013131:Spine / Q000000981:diagnostic imaging / Q000378:metabolism; D013569:Synapses / Q000502:physiology; D013997:Time Factors
chemical_list: D002118:Calcium