title: Unraveling the mechanisms of progressive peritoneal membrane fibrosis.
abstract: Continuous glucose exposure contributes to severe ultrafiltration failure in peritoneal dialysis. In their study, Wang et al. describe a mechanistic pathway involving direct activation by glucose of mesothelial cell protein kinase C α that, when blocked, or absent in a mouse knockout model, prevents fibrosis and the associated reduction in ultrafiltration. Interestingly, this pathway involves the 3 main mechanisms of membrane injury (inflammation, neoangiogenesis, and fibrogenesis), offering a potential target for therapeutic intervention.
authors.affiliation: Institute for Applied Clinical Sciences, Keele University, Newcastle-under-Lyme, UK; University Hospitals of North Midlands, Stoke-on-Trent, UK. Electronic address: Simonj.Davies@uhns.nhs.uk.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Davies
mesh_terms: D000818:Animals; D015314:Dialysis Solutions; D004848:Epithelium; D005355:Fibrosis; D010530:Peritoneal Dialysis; D056627:Peritoneal Fibrosis; D010537:Peritoneum
chemical_list: D015314:Dialysis Solutions