title: Mesoporous WO3 Nanofibers with Protein-Templated Nanoscale Catalysts for Detection of Trace Biomarkers in Exhaled Breath.
abstract: Highly selective detection, rapid response (<20 s), and superior sensitivity (Rair/Rgas> 50) against specific target gases, particularly at the 1 ppm level, still remain considerable challenges in gas sensor applications. We propose a rational design and facile synthesis concept for achieving exceptionally sensitive and selective detection of trace target biomarkers in exhaled human breath using a protein nanocage templating route for sensitizing electrospun nanofibers (NFs). The mesoporous WO3 NFs, functionalized with well-dispersed nanoscale Pt, Pd, and Rh catalytic nanoparticles (NPs), exhibit excellent sensing performance, even at parts per billion level concentrations of gases in a humid atmosphere. Functionalized WO3 NFs with nanoscale catalysts are demonstrated to show great promise for the reliable diagnosis of diseases.
authors.forename: Sang-Joon
authors.initials: SJ
authors.lastname: Kim
authors.forename: Seon-Jin
authors.initials: SJ
authors.lastname: Choi
authors.forename: Ji-Soo
authors.initials: JS
authors.lastname: Jang
authors.forename: Nam-Hoon
authors.initials: NH
authors.lastname: Kim
authors.affiliation: Platforms Engineering Group, Intel GmbH , Munich 85622, Germany.
authors.forename: Meggie
authors.initials: M
authors.lastname: Hakim
authors.affiliation: Department of Materials Science and Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors.forename: Harry L
authors.initials: HL
authors.lastname: Tuller
authors.forename: Il-Doo
authors.initials: ID
authors.lastname: Kim
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D001944:Breath Tests; D002384:Catalysis; D006801:Humans; D057139:Nanofibers; D010087:Oxides; D014414:Tungsten
chemical_list: D015415:Biomarkers; D010087:Oxides; D014414:Tungsten
keywords: WO3 nanofiber; bioinspired catalyst; diagnosis of diseases; electrospinning; exhaled breath sensor