title: Transdiagnostic and Transcultural: Pilot Study of Unified Protocol for Depressive and Anxiety Disorders in Japan.
abstract: Unified protocol (UP) is a transdiagnostic cognitive behavior therapy for emotional disorders. It remains unknown whether UP is applicable for use in non-Western countries and for depressive disorders. We therefore examined its feasibility for a Japanese clinical population using this clinical trial design, which is multicentered, open-labeled, and single-armed (Clinical registry: UMIN000008322). The primary outcome was severity of anxiety symptoms, as assessed using Structured Interview Guide for the Hamilton Anxiety Rating Scale. Secondary outcomes were depressive symptoms, clinical global impression, functioning, quality of life, affectivity, emotion regulation, and adverse events. Of the 28 prospective participants, 17 were eligible and enrolled (depressive disorders=9, anxiety disorders=8). Severity of anxiety symptoms, which decreased significantly after the intervention, remained low for 3months (Hedges' g=1.29, 95% CI=0.56-2.06). Similar tendencies were observed for secondary outcome measures. No severe adverse event occurred. Two participants dropped out of the intervention. High treatment adherence and interrater reliability were confirmed. Results suggest the feasibility of UP in the Japanese context sufficient to warrant a larger clinical trial.
authors.affiliation: National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Kodaira. Electronic address: masayait@ncnp.go.jp.
authors.forename: Masaya
authors.initials: M
authors.lastname: Ito
authors.affiliation: National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Kodaira.
authors.forename: Masaru
authors.initials: M
authors.lastname: Horikoshi
authors.affiliation: National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Kodaira.
authors.forename: Noriko
authors.initials: N
authors.lastname: Kato
authors.affiliation: National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Kodaira.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Oe
authors.affiliation: Kanto Junior College, Tatebayashi.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Fujisato
authors.affiliation: Tokyo Medical University.
authors.forename: Shun
authors.initials: S
authors.lastname: Nakajima
authors.affiliation: National Center of Neurology and Psychiatry, Tokyo.
authors.forename: Ayako
authors.initials: A
authors.lastname: Kanie
authors.affiliation: National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Kodaira.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Miyamae
authors.affiliation: The Institute of Statistical Mathematics, Tachikawa.
authors.forename: Yoshitake
authors.initials: Y
authors.lastname: Takebayashi
authors.affiliation: Gifu University.
authors.forename: Ryo
authors.initials: R
authors.lastname: Horita
authors.affiliation: National Disaster Medical Center, Tachikawa.
authors.forename: Masato
authors.initials: M
authors.lastname: Usuki
authors.affiliation: Keio University School of Medicine.
authors.forename: Atsuo
authors.initials: A
authors.lastname: Nakagawa
authors.affiliation: National Center for Cognitive Behavior Therapy and Research, National Center of Neurology and Psychiatry, Kodaira.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ono
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis / Q000628:therapy*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003431:Cross-Cultural Comparison; D003866:Depressive Disorder / Q000175:diagnosis / Q000628:therapy*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D010865:Pilot Projects
keywords: anxiety disorder; cognitive behavioral therapy; culture; depressive disorder