title: The possible counteractive effect of gold nanoparticles against streptozotocin-induced type 1 diabetes in young male albino rats.
abstract: The current study was performed to study the effect of biologically synthesised gold nanoparticles (AuNPs) to control hyperglycaemic conditions in streptozotocin (STZ)-induced diabetic mice. In this study, the rats were divided into four groups: Group I normal control rats (non-diabetic, untreated); Group II diabetes-induced rats used as diabetic controls DC (diabetic, untreated). Group III diabetes-induced rats treated with AuNPs DT; Group IV normal rats treated with AuNPs NT. Diabetes was induced by administering an intraperitoneal injection of a freshly prepared solution of STZ (50mg/kg body weight (bw)). The glucose level was significantly increased in the diabetic control rats compared with the controls (P<0.001). Decreased liver function and kidney function were detected in the diabetic treated rats and normal treated rats after AuNP administration compared with the controls. The present study is the first to demonstrate that AuNPs significantly enhance antioxidant production in STZ-induced diabetic rats, a recognised model of type 1 diabetes mellitus (T1DM).
authors.affiliation: Zoology Department, Faculty of Science, King Saud University, Ain Shams University, Cairo, Egypt.
authors.forename: Manar E
authors.initials: ME
authors.lastname: Selim
authors.affiliation: Physics Department, Faculty of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Awatif A
authors.initials: AA
authors.lastname: Hendi
authors.affiliation: Physics Department, Faculty of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Ebtesam
authors.initials: E
authors.lastname: Alfallaj
mesh_terms: D000367:Age Factors; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D004798:Enzymes / Q000097:blood; D005951:Glucose Tolerance Test; D017612:Gold Compounds / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D053768:Metal Nanoparticles; D051381:Rats; D013311:Streptozocin; D013997:Time Factors; D014527:Uric Acid / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D004798:Enzymes; D017612:Gold Compounds; D007004:Hypoglycemic Agents; D014527:Uric Acid; D013311:Streptozocin; D003404:Creatinine