title: Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy.
abstract: OBJECTIVE
  To identify factors that influence long-term liver function following radiofrequency ablation (RFA) in patients with viral hepatitis-related hepatocellular carcinoma.
  
  
  METHODS
  A total of 123 patients with hepatitis B virus- or hepatitis C virus-related hepatocellular car-cinoma (HCC) (n = 12 and n = 111, respectively) were enrolled. Cumulative rates of worsening Child-Pugh (CP) scores (defined as a 2-point increase) were examined.
  
  
  RESULTS
  CP score worsening was confirmed in 22 patients over a mean follow-up period of 43.8 ± 26.3 mo. Multivariate analysis identified CP class, platelet count, and aspartate aminotransferase levels as signi-ficant predictors of a worsening CP score (P = 0.000, P = 0.011 and P = 0.024, respectively). In contrast, repeated RFA was not identified as a risk factor for liver function deterioration.
  
  
  CONCLUSIONS
  Long-term liver function following RFA was dependent on liver functional reserve, the degree of fibrosis present, and the activity of the hepatitis condition for this cohort. Therefore, in order to maintain liver function for an extended period following RFA, suppression of viral hepatitis activity is important even after the treatment of HCC.
authors.affiliation: Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Hiroki Syo, Masao Iwao, Masanori Tokoro, Junko Nishimura, Tetsu Mori, Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu-City, Oita 879-5593, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Honda
authors.affiliation: Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Hiroki Syo, Masao Iwao, Masanori Tokoro, Junko Nishimura, Tetsu Mori, Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu-City, Oita 879-5593, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Seike
authors.affiliation: Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Hiroki Syo, Masao Iwao, Masanori Tokoro, Junko Nishimura, Tetsu Mori, Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu-City, Oita 879-5593, Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Oribe
authors.affiliation: Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Hiroki Syo, Masao Iwao, Masanori Tokoro, Junko Nishimura, Tetsu Mori, Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu-City, Oita 879-5593, Japan.
authors.forename: Mizuki
authors.initials: M
authors.lastname: Endo
authors.affiliation: Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Hiroki Syo, Masao Iwao, Masanori Tokoro, Junko Nishimura, Tetsu Mori, Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu-City, Oita 879-5593, Japan.
authors.forename: Mie
authors.initials: M
authors.lastname: Arakawa
authors.affiliation: Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Hiroki Syo, Masao Iwao, Masanori Tokoro, Junko Nishimura, Tetsu Mori, Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu-City, Oita 879-5593, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Syo
authors.affiliation: Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Hiroki Syo, Masao Iwao, Masanori Tokoro, Junko Nishimura, Tetsu Mori, Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu-City, Oita 879-5593, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Iwao
authors.affiliation: Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Hiroki Syo, Masao Iwao, Masanori Tokoro, Junko Nishimura, Tetsu Mori, Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu-City, Oita 879-5593, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Tokoro
authors.affiliation: Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Hiroki Syo, Masao Iwao, Masanori Tokoro, Junko Nishimura, Tetsu Mori, Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu-City, Oita 879-5593, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Nishimura
authors.affiliation: Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Hiroki Syo, Masao Iwao, Masanori Tokoro, Junko Nishimura, Tetsu Mori, Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu-City, Oita 879-5593, Japan.
authors.forename: Tetsu
authors.initials: T
authors.lastname: Mori
authors.affiliation: Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Hiroki Syo, Masao Iwao, Masanori Tokoro, Junko Nishimura, Tetsu Mori, Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu-City, Oita 879-5593, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yamashita
authors.affiliation: Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Hiroki Syo, Masao Iwao, Masanori Tokoro, Junko Nishimura, Tetsu Mori, Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu-City, Oita 879-5593, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukuchi
authors.affiliation: Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Hiroki Syo, Masao Iwao, Masanori Tokoro, Junko Nishimura, Tetsu Mori, Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu-City, Oita 879-5593, Japan.
authors.forename: Toyokichi
authors.initials: T
authors.lastname: Muro
authors.affiliation: Koichi Honda, Masataka Seike, Junya Oribe, Mizuki Endo, Mie Arakawa, Hiroki Syo, Masao Iwao, Masanori Tokoro, Junko Nishimura, Tetsu Mori, Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu-City, Oita 879-5593, Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Murakami
keywords: Hepatitis B; Hepatitis C; Hepatocellular carcinoma; Liver function; Radiofrequency ablation