title: Dietary Interventions, Cardiovascular Aging, and Disease: Animal Models and Human Studies.
abstract: Recent studies indicate that dietary interventions have the potential to prevent and even treat cardiovascular disease, which is the leading cause of death. Many of these studies have focused on various animal models that are able to recreate one or more conditions or elevate risk factors that characterize the disease. Here, we highlight macronutrient-focused interventions in both mammalian model organisms and humans with emphasis on some of the most relevant and well-established diets known to be associated with cardiovascular disease prevention and treatment. We also discuss more recent dietary interventions in rodents, monkeys, and humans, which affect atherosclerosis and cardiovascular diseases with focus on those that also delay aging.
authors.affiliation: From the Longevity Institute and Leonard Davis School of Gerontology (H.M., S.D.B, V.D.L.), University of Southern California, Los Angeles, CA; and IFOM, FIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milano, Italy (V.D.L.).
authors.forename: Hamed
authors.initials: H
authors.lastname: Mirzaei
authors.affiliation: From the Longevity Institute and Leonard Davis School of Gerontology (H.M., S.D.B, V.D.L.), University of Southern California, Los Angeles, CA; and IFOM, FIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milano, Italy (V.D.L.).
authors.forename: Stefano
authors.initials: S
authors.lastname: Di Biase
authors.affiliation: From the Longevity Institute and Leonard Davis School of Gerontology (H.M., S.D.B, V.D.L.), University of Southern California, Los Angeles, CA; and IFOM, FIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milano, Italy (V.D.L.). vlongo@usc.edu.
authors.forename: Valter D
authors.initials: VD
authors.lastname: Longo
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics; D003327:Coronary Disease / Q000178:diet therapy* / Q000209:etiology / Q000517:prevention & control; D018753:Diet, Protein-Restricted; D006321:Heart / Q000254:growth & development*; D006801:Humans; D051379:Mice; D009765:Obesity / Q000150:complications / Q000235:genetics; D051381:Rats
chemical_list: D001057:Apolipoproteins E
keywords: CR; DR; FMD; health span; protein restriction