title: Ozone therapy effectiveness in patients with ulcerous lesions due to diabetes mellitus.
abstract: BACKGROUND
  Development of purulo-necrotic foot lesions is one of the most dangerous surgical complications of diabetes mellitus, it causes high lethality, early disability, considerable economical expenses on treatment and rehabilitation. Mentioned above determine substantial actuality of diabetic foot problem and condition the necessity of further search of new ways and effective methods of lower extremities lesions complex treatment.
  
  
  OBJECTIVE
  of our research was to study the effectiveness of ozone use in complex therapy among patients with diabetic foot.
  
  
  METHODS
  Under our observation were 47 patients with I and II stages of diabetic foot that correspond to superficial and deep ulcers without involving of subcutaneous tissue, ligaments, tendons and muscles into the process, without bone lesion, phlegmons and abscess forming according to Meggit-Wagner (1978) classification. Depending on treatment every group of patients was divided into subgroups. B group composed patients that received traditional therapy.A group composed patients that along with traditional therapy course received course of systemic and regional ozone therapy for 12-14 days, one session per day. Cytological examination of discharge from wounds was carried, lipid peroxidation state and antioxidant protection state was assessed.
  
  
  RESULTS
  Ozone use has more evident clinical effect, significantly affects the phase course of wound process, promotes the improvement of lipid peroxidation and antioxidant protection indexes, reduces the length of hospital stay and term of treatment of patients with diabetic foot. СONCLUSIONS: Studies conducted showed that including of ozone therapy into complex surgical treatment has positive effect on wound process.
authors.affiliation: Uzhgorod National University, Department of Surgical Disciplines, Uzhgorod, Ukraine.
authors.forename: Myroslav V
authors.initials: MV
authors.lastname: Rosul
authors.affiliation: Uzhgorod National University, Department of Surgical Disciplines, Uzhgorod, Ukraine.
authors.forename: Bohdan M
authors.initials: BM
authors.lastname: Patskan
mesh_terms: D000368:Aged; D015331:Cohort Studies; D017719:Diabetic Foot / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D016523:Foot Ulcer / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000627:therapeutic use*; D010126:Ozone / Q000627:therapeutic use*; D011044:Poland; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010126:Ozone; D010100:Oxygen