title: Remote ischaemic conditioning and remodelling following myocardial infarction: current evidence and future perspectives.
abstract: Remote ischaemic conditioning (rIC) has demonstrated its effectiveness as a powerful cardioprotective tool in number of preclinical and limited clinical settings. More recently, ischaemic postconditioning given after an ischaemic event such as a myocardial infarction (MI) has shown not only to reduce infarct size but also to have beneficial effects on acute remodelling post-MI and to reduce the burden of heart failure and other detrimental outcomes. Building on this platform, repeated rIC over a number of days has the potential to augment the protective process even further. This review considers the current evidence base from which the concept of rIC in the setting of post-MI remodelling has grown. It also discusses the ongoing and planned clinical trials which are attempting to elucidate whether the protection imparted by rIC in the preclinical setting can be translated to the clinic and become a realistic weapon in the clinician's armoury to tackle acute remodelling and heart failure post-MI.
authors.affiliation: Department of Cardiovascular Sciences, Glenfield General Hospital, University of Leicester, Leicester, LE3 9QP, UK. andrew.vanezis@nhs.net.
authors.forename: A P
authors.initials: AP
authors.lastname: Vanezis
authors.affiliation: Department of Cardiovascular Sciences, Glenfield General Hospital, University of Leicester, Leicester, LE3 9QP, UK.
authors.forename: G C
authors.initials: GC
authors.lastname: Rodrigo
authors.affiliation: Department of Cardiovascular Sciences, Glenfield General Hospital, University of Leicester, Leicester, LE3 9QP, UK.
authors.forename: I B
authors.initials: IB
authors.lastname: Squire
authors.affiliation: Department of Cardiovascular Sciences, Glenfield General Hospital, University of Leicester, Leicester, LE3 9QP, UK.
authors.forename: N J
authors.initials: NJ
authors.lastname: Samani
mesh_terms: D006333:Heart Failure / Q000517:prevention & control*; D006801:Humans; D057775:Ischemic Postconditioning / Q000379:methods*; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology*; D016032:Randomized Controlled Trials as Topic; D020257:Ventricular Remodeling
keywords: Cardioprotection; Heart failure; Myocardial infarction; Remodelling; Remote ischaemic conditioning