title: Long-term safety in living kidney donors for paediatric transplantation. Single-centre prospective study.
abstract: BACKGROUND
  There is enough evidence concerning the short-term safety of living donors after kidney transplantation. However, long-term complications continue to be studied, with a particular interest in young donors. Previous studies have been conducted in older donors for adult renal patients. We present a study of long-term complications in kidney donors for our paediatric population.
  
  
  METHODS
  We carried out a long-term donor study for the 54 living kidney-donor transplantations performed at our department from 1979 to June 2014. We monitored the glomerular filtration rate (GFR) on the basis of 24-hour urine creatinine clearance, 24-hour proteinuria and the development of arterial hypertension in the 48 donors who were followed up for more than one year. Only the 39 patients who were exclusively followed up by our department have been included in the results analysis.
  
  
  RESULTS
  GFR through creatinine clearance was stable after an initial decrease. No proteinuria was observed in any of the cases. One patient developed chronic kidney disease (CKD), which resulted in a cumulative incidence of 2%. GFR below 60mL/min/1.73 m2was not reported in any other patients. Arterial hypertension was diagnosed in 25% of donors, 90% of which were treated with antihypertensives.
  
  
  CONCLUSIONS
  Risk of CKD and hypertension in living kidney donors for paediatric recipients, who are carefully monitored throughout their evolution, is similar to that of the general population. Therefore, this technique appears to be safe in both the short and long term.
authors.affiliation: Servicio de Nefrología Pediátrica, Hospital La Fe, Valencia, España.
authors.forename: J
authors.initials: J
authors.lastname: Martin Benlloch
authors.affiliation: Servicio de Nefrología Pediátrica, Hospital La Fe, Valencia, España.
authors.forename: E
authors.initials: E
authors.lastname: Román Ortiz
authors.affiliation: Servicio de Nefrología Pediátrica, Hospital La Fe, Valencia, España. Electronic address: mendizabal_san@gva.es.
authors.forename: S
authors.initials: S
authors.lastname: Mendizabal Oteiza
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D061214:Patient Safety; D011446:Prospective Studies; D055815:Young Adult
keywords: Advanced chronic kidney disease; Arterial hypertension; Donante renal vivo; Enfermedad renal crónica avanzada; Hipertensión arterial; Kidney transplantation; Living kidney donor; Paediatric transplantation; Trasplante infantil; Trasplante renal