title: Organocatalytic Enantioselective Intramolecular Oxa-Michael Reaction of Enols: Synthesis of Chiral Isochromenes.
abstract: An unprecedented enantioselective intramolecular oxa-Michael reaction of enols has been described. A squaramide-containing tertiary amine based bifunctional organocatalyst efficiently activates the o-homoformyl chalcones to provide the chiral isochromenes in moderate yields and good to excellent enantioselectivities. Further, late-stage functionalizations of the vinyl ether moiety of the chiral isochromene products have also been exemplified.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhauri, Bhopal 462066, India.
authors.forename: Biswajit
authors.initials: B
authors.lastname: Parhi
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhauri, Bhopal 462066, India.
authors.forename: Jitendra
authors.initials: J
authors.lastname: Gurjar
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhauri, Bhopal 462066, India.
authors.forename: Suman
authors.initials: S
authors.lastname: Pramanik
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhauri, Bhopal 462066, India.
authors.forename: Abhisek
authors.initials: A
authors.lastname: Midya
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal , Bhauri, Bhopal 462066, India.
authors.forename: Prasanta
authors.initials: P
authors.lastname: Ghorai