title: Decompressive Craniectomy for Stroke: Early Cranioplasty Is a Predictor for Postoperative Complications.
abstract: BACKGROUND
  Previous clinical studies assumed that early cranioplasty (CP) was mandatory for a favorable neurologic recovery after decompressive craniectomy (DC) for malignant stroke. However, the appropriate timing of the CP procedure after DC remains controversial. This study assessed patients who underwent DC because of cerebral ischemia to determine the appropriate time point of CP and surgical-associated complications.
  
  
  METHODS
  Data from the period 2007-2014 were retrospectively evaluated. CP was performed in 75 patients who previously underwent DC because of supratentorial cerebral infarction. Patients were divided into 2 groups (early CP vs. late CP) according to the time from DC to CP (<3 months vs. ≥3 months). Patient characteristics, timing of CP, and postoperative complications associated with CP were analyzed.
  
  
  RESULTS
  CP was performed early in 12 patients (16%) and late in 63 patients (84%). The complication rate after CP was 18%; complications included wound healing disturbance in 8 patients (11%), epidural hematoma or subdural hematoma in 4 patients (4%), and others in 2 patients (3%). Patients with early CP experienced significantly more complications compared with patients with late CP after initial DC (5 of 12 patients [42%] vs. 8 of 63 patients [13%]; P = 0.02). In multivariate analysis, early CP was a significant predictor of postoperative complications after CP (odds ratio = 6.04; 95% confidence interval, 1.4-24.9; P = 0.01).
  
  
  CONCLUSIONS
  The present data suggest that patients who underwent DC for stroke might benefit from CP performed >3 months after DC owing to a lower rate of wound infection.
authors.affiliation: Department of Neurosurgery, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany. Electronic address: valeri.borger@ukb.uni-bonn.de.
authors.forename: Valeri
authors.initials: V
authors.lastname: Borger
authors.affiliation: Department of Neurosurgery, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany.
authors.forename: Patrick
authors.initials: P
authors.lastname: Schuss
authors.affiliation: Department of Neurosurgery, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Kinfe
authors.affiliation: Department of Neurosurgery, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Vatter
authors.affiliation: Department of Neurosurgery, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany.
authors.forename: Erdem
authors.initials: E
authors.lastname: Güresir
mesh_terms: D000328:Adult; D000368:Aged; D056424:Decompressive Craniectomy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000209:etiology*; D011237:Predictive Value of Tests; D019651:Plastic Surgery Procedures / Q000009:adverse effects*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D020521:Stroke / Q000601:surgery*
keywords: Complications; Cranioplasty; Decompressive craniectomy; Stroke