title: Evaluation of miR-302c-3p as prognostic biomarkers in glioma patients.
abstract: This study aimed to explore the clinicopathological and prognostic significance of miR-302c-3p in glioma.
  
  
  
  The expression of miR-302c-3p in glioma tissues and normal brain tissues was measured using real-time PCR. Clinicopathological associations of miR-302c-3p expression in glioma were analyzed. The Kaplan-Meier method was used to determine the survival curves. Univariate and multivariate analysis were performed using the Cox proportional hazard analysis.
  
  
  
  The relative expression of miR-302c-3p in glioma tissues was significantly lower than that in non-neoplastic brain tissues (p < 0.001). The decreased expression of miR-302c-3p in glioma was positively associated with WHO grade (p < 0.001) and Karnofsky performance status (KPS) score (p = 0.016). We found patients with low miR-302c-3p expression had significantly poorer OS (p = 0.0057) and PFS (p = 0.0092) by Kaplan-Meier method. Furthermore, multivariate regression analysis identified low miR-302c-3p expression as an independent predictor of poor survival.
  
  
  
  Our results revealed that miR-302c-3p may serve as a tumor suppressor of malignant glioma and be used as a novel biomarker to predict the clinical prognostic of patients with gliomas.
authors.affiliation: Department of Neurosurgery, Linyi People's Hospital, Linyi, Shandong, P.R. China. zhunn0999@163.com.
authors.forename: G-D
authors.initials: GD
authors.lastname: Zheng
authors.forename: Y-U
authors.initials: YU
authors.lastname: Wang
authors.forename: X-D
authors.initials: XD
authors.lastname: Zhu
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma; D006801:Humans; D053208:Kaplan-Meier Estimate; D035683:MicroRNAs / Q000096:biosynthesis*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs