title: MicroRNA-130a regulates cell malignancy by targeting RECK in chronic myeloid leukemia.
abstract: Emerging evidence has indicated that microRNAs are involved in tumor development and progression, acting as either tumor suppressors or oncogenes. In this study, we aimed to investigate the role of miR-130a in the pathogenesis of chronic myeloid leukemia (CML). Functional studies indicate that over-expression of miR-130a in A562 CML cells dramatically suppresses cell proliferation and induces cell apoptosis both in vitro and in vivo. Furthermore, we demonstrate that the transcriptional regulator RECK is a target of miR-130a. In conclusion, our study suggests that miR-130a may function as a novel tumor suppressor in CML, and its anti-oncogenic activity may involve the direct targeting and inhibition of RECK.
authors.affiliation: Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Xiangyang 441021, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 1277# Jiefang Avenue, Wuhan 430022, China.
authors.forename: Yaohui
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Xiangyang 441021, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Xiangyang Central Hospital, Hubei University of Arts and Science Xiangyang 441021, China.
authors.forename: Tienan
authors.initials: T
authors.lastname: Yi
authors.affiliation: Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 1277# Jiefang Avenue, Wuhan 430022, China.
authors.forename: Weiming
authors.initials: W
authors.lastname: Li
keywords: A562; Chronic myeloid leukemia (CML); RECK; invasion; miR-130a; migration; target therapy