title: Classical-Reaction-Driven Stereo- and Regioselective C(sp(3) )-H Functionalization of Aliphatic Amines.
abstract: A large variety of synthetic methods have been developed for the synthesis of functionalized aliphatic amines because of their broad spectrum of application. Metallic reagents/catalysts and/or toxic oxidants are involved in most of the cases. Direct CH functionalization of aliphatic amines via their classical condensation reactions with suitable carbonyl compounds is advantageous because this method avoids hazardous metallic reagents, toxic oxidants and pre-activation/pre-functionalization step(s). In this account, the concept of direct CH functionalization of aliphatic amines based on the classical condensation-isomerization-addition (CIA) strategy followed by recent contributions from our ongoing research in the field along with relevant examples from other groups are described. Successes in stereo- and regioselective CC and CO bond formation via direct α- as well as β-C(sp(3) )-H functionalization are discussed.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, Assam (India).
authors.forename: Sujit
authors.initials: S
authors.lastname: Mahato
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, Assam (India).
authors.forename: Chandan K
authors.initials: CK
authors.lastname: Jana
keywords: CH functionalization; amines; fused-ring systems; green chemistry; nitrogen heterocycles