title: Cryptococcosis-the impact of delay to diagnosis.
abstract: Cryptococcosis is a mycotic disease caused by the yeast Cryptococcus sp. It is associated with significant mortality and morbidity, including long-term neurological sequelae. It is not known whether the high morbidity observed is related to a delay in diagnosis. A retrospective chart review of all cryptococcal infections that had been diagnosed in the region between 1997 and 2015 was performed. Twenty-nine cases were identified. Overall mortality rate was 10.3%, with an attributable mortality rate of 6.9%. Forty-five per cent of patients with central nervous system involvement developed long-term neurological deficits. Significant associations were noted between those with and without long-term neurological deficits and in both time from onset of symptoms to diagnosis (median of 45.5 days versus 18.5 days, respectively) and time from presentation to diagnosis (median 14.5 days versus 7 days, respectively). In addition, raised intracranial pressure (p 0.03) and female gender (p 0.02) were significantly associated with poor neurological outcomes. This highlights the importance of early diagnosis and the need to limit raised intracranial pressure to minimize long-term neurological deficits.
authors.affiliation: Department of Infectious Diseases, Townsville Hospital, Douglas, Queensland, Australia. Electronic address: chaw.aye@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Aye
authors.affiliation: Department of Infectious Diseases, Townsville Hospital, Douglas, Queensland, Australia; Department of Microbiology, Pathology Queensland, Townsville Hospital, Douglas, Queensland, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Henderson
authors.affiliation: Department of Infectious Diseases, Townsville Hospital, Douglas, Queensland, Australia.
authors.forename: H
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Infectious Diseases, Townsville Hospital, Douglas, Queensland, Australia; Department of Microbiology, Pathology Queensland, Townsville Hospital, Douglas, Queensland, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Norton
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057210:Delayed Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D008875:Middle Aged; D009422:Nervous System Diseases / Q000453:epidemiology* / Q000209:etiology*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult
keywords: Cryptococcosis; Deficit; Delay; Diagnosis; Neurology; Outcome