title: Influence of different anesthetic and analgesic methods on early cognitive function of elderly patients receiving non-cardiac surgery.
abstract: OBJECTIVE
  To discuss over influence of two different anesthetic and analgesic methods on early cognitive function of elderly patients who received non-cardiac surgery.
  
  
  METHODS
  Two hundred and six elderly patients who underwent non-cardiac surgery were selected as research subjects. They were randomly divided into observation group (103 cases) and control group (103 cases). Patients in observation group were given combined spinal and epidural anesthesia and epidural analgesia, while patients in control group adopted general anesthesia and intravenous analgesia. Neurological function test was carried out one day before surgery and on the 7(th) day after surgery. Moreover, changes of postoperative pain degree, neuropsychological function and cognitive function were observed and compared.
  
  
  RESULTS
  On the 7(th) day after surgery, incidence of cognition impairment in observation group and control group was 48.50% (50/103 cases) and 44.70% (46/103 cases), and difference between groups had no statistical significance. Visual Analogue Scale (VAS) Score of observation group was much lower than control group in the 12(th), 24(th) and 48(th) h after surgery (p < 0.05). Logistic regression analysis suggested that, short education years and general surgery were independent risk factors for early cognition impairment.
  
  
  CONCLUSIONS
  About 46.60% elderly patients undergoing non-cardiac surgery developed cognition impairment, but influence of different anesthetic and analgesic methods on incidence of postoperative cognition impairment of elderly patients had no significant difference.
authors.affiliation: Yong Wang, Department of Anesthesiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. Key-Disciplines Laboratory Clinical-Medicine Henan, Zhengzhou, 450052, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Jie Zhang, Department of Anesthesiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. Key-Disciplines Laboratory Clinical-Medicine Henan, Zhengzhou, 450052, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Shuijun Zhang, Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. Key-Disciplines Laboratory Clinical-Medicine Henan, Zhengzhou, 450052, China.
authors.forename: Shuijun
authors.initials: S
authors.lastname: Zhang
keywords: Anesthesia; Neurological function; Postoperative cognition impairment