title: The Effects of Radiofrequency or Cryothermal Ablation on Biomechanical Properties of Isolated Human or Swine Cardiac Tissues.
abstract: Changes in cardiac tissue properties following the application of various ablation modalities may lead to the development of an array of associated complications. The application of either radio frequency (RF) or cryothermal ablations will alter the biomechanical properties of various cardiac tissues in a differential manner; in some cases, this may be attributable to increased incidences of cardiac tamponade, pulmonary vein stenosis, and/or atrial-esophageal fistula. Thus, a greater understanding of the underlying changes in tissue properties induced by ablative therapies will ultimately promote safer and more efficacious procedures. The effects of applied RF or cryothermal energies on the biomechanical properties of the pulmonary vein, left atrial, or right atrial samples ([Formula: see text]) were examined from fresh excised porcine ([Formula: see text]) and donated human tissue ([Formula: see text]). RF ablations were found to reduce the tensile strength of the porcine cardiac specimens ([Formula: see text]), and a similar trend was noted for human samples. Cryoablations did not have a significant impact on the tissue properties compared with the untreated tissue specimens. Locational and species differences were also observed in this experimental paradigm ([Formula: see text]. Incorporating these findings into cardiac device design and computational modeling should aid to reduce the risks of complications associated with tissue property changes resulting from cardiac ablative procedures.
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Quallich
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Kriege
authors.forename: Paul A
authors.initials: PA
authors.lastname: Iaizzo
keywords: Atrial fibrillation; biomechanical properties; cryoablation; radiofrequency ablation