title: Pulmonary Arterial Hypertension and Neonatal Arterial Switch Surgery for Correction of Transposition of the Great Arteries.
abstract: OBJECTIVE
  There are few reports of the appearance of pulmonary arterial hypertension following arterial switch surgery in the neonatal period to correct transposition of the great arteries. We assessed the frequency and clinical pattern of this complication in our series of patients.
  
  
  METHODS
  Our database was reviewed to select patients with transposition of the great arteries corrected by neonatal arterial switch at our hospital and who developed pulmonary hypertension over time.
  
  
  RESULTS
  We identified 2 (1.3%) patients with transposition of the great arteries successfully repaired in the first week of life who later experienced pulmonary arterial hypertension. The first patient was a 7-year-old girl diagnosed with severe pulmonary hypertension at age 8 months who did not respond to medical treatment and required lung transplantation. The anatomic pathology findings were consistent with severe pulmonary arterial hypertension. The second patient was a 24-month-old boy diagnosed with severe pulmonary hypertension at age 13 months who did not respond to medical therapy.
  
  
  CONCLUSIONS
  Pulmonary hypertension is a rare but very severe complication that should be investigated in all patients with transposition of the great arteries who have undergone neonatal arterial switch, in order to start early aggressive therapy for affected patients, given the poor therapeutic response and poor prognosis involved.
authors.affiliation: Instituto Pediátrico del Corazón, Hospital Universitario 12 de Octubre, Madrid, Spain. Electronic address: p.dominguez.manzano@gmail.com.
authors.forename: Paula
authors.initials: P
authors.lastname: Domínguez Manzano
authors.affiliation: Instituto Pediátrico del Corazón, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Mendoza Soto
authors.affiliation: Instituto Pediátrico del Corazón, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Violeta
authors.initials: V
authors.lastname: Román Barba
authors.affiliation: Sección de Neumología Pediátrica y Fibrosis Quística, Hospital Universitario Vall d'Hebron, Universitat Autónoma de Barcelona, Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Moreno Galdó
authors.affiliation: Unidad de Medicina Fetal, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Galindo Izquierdo
mesh_terms: D000069278:Arterial Switch Operation / Q000009:adverse effects*; D006328:Cardiac Catheterization; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology*; D011669:Pulmonary Wedge Pressure / Q000502:physiology*; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D014188:Transposition of Great Vessels / Q000601:surgery*
keywords: Arterial switch; Hipertensión arterial pulmonar; Pulmonary arterial hypertension; Switch arterial; Transposición de grandes arterias; Transposition of the great arteries