title: Inflammasome, IL-1 and inflammation in ozone-induced lung injury.
abstract: Exposure to ambient ozone causes airway hyperreactivity and lung inflammation, which represent an important health concern in humans. Recent clinical and experimental studies contributed to the understanding of the mechanisms of epithelial injury, inflammation and airway hyperreactivity, which is reviewed here. The present data suggest that ozone induced oxidative stress causes inflammasome activation with the release of IL-1, other cytokines and proteases driving lung inflammation leading to the destruction of alveolar epithelia with emphysema and respiratory failure. Insights in the pathogenic pathway may allow to identify novel biomarkers of ozone-induced lung disease and therapeutic targets.
authors.affiliation: ArtImmune SAS13 Avenue Buffon, Orleans, France; CNRS, UMR7355, Experimental and Molecular Immunology and Neurogenetics45071 Orleans, France.
authors.forename: Chloé
authors.initials: C
authors.lastname: Michaudel
authors.affiliation: CNRS, UMR7355, Experimental and Molecular Immunology and Neurogenetics 45071 Orleans, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Couturier-Maillard
authors.affiliation: CNRS, UMR7355, Experimental and Molecular Immunology and Neurogenetics 45071 Orleans, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Chenuet
authors.affiliation: CNRS, UMR7355, Experimental and Molecular Immunology and Neurogenetics 45071 Orleans, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Maillet
authors.affiliation: CNRS, UMR7355, Experimental and Molecular Immunology and Neurogenetics 45071 Orleans, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Mura
authors.affiliation: CNRS, UMR7355, Experimental and Molecular Immunology and Neurogenetics 45071 Orleans, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Couillin
authors.affiliation: CNRS, UMR7355, Experimental and Molecular Immunology and Neurogenetics 45071 Orleans, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Gombault
authors.affiliation: CNRS, UMR7355, Experimental and Molecular Immunology and Neurogenetics 45071 Orleans, France.
authors.forename: Valérie F
authors.initials: VF
authors.lastname: Quesniaux
authors.affiliation: ULB, Bruxelles Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain Brussels, Belgium.
authors.forename: François
authors.initials: F
authors.lastname: Huaux
authors.affiliation: CNRS, UMR7355, Experimental and Molecular Immunology and Neurogenetics45071 Orleans, France; IDM, University of Cape TownRSA.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Ryffel
keywords: DAMP; IL-1; IL-17; NLRP3 inflammasome; ROS; airway hyperreactivity