title: Host immune cellular reactions in corneal neovascularization.
abstract: Corneal neovascularization (CNV) is a global important cause of visual impairment. The immune mechanisms leading to corneal heme- and lymphangiogenesis have been extensively studied over the past years as more attempts were made to develop better prophylactic and therapeutic measures. This article aims to discuss immune cells of particular relevance to CNV, with a focus on macrophages, Th17 cells, dendritic cells and the underlying immunology of common pathologies involving neovascularization of the cornea. Hopefully, a thorough understanding of these topics would propel the efforts to halt the detrimental effects of CNV.
authors.affiliation: Doheny Eye Institute, University of California, Los Angeles, CA 90033, USA; Ophthalmology Department, David Geffen School of Medicine, University of California, Los Angeles, CA 90033, USA.
authors.forename: Nizar S
authors.initials: NS
authors.lastname: Abdelfattah
authors.affiliation: Faculty of Medicine, Cairo University, Cairo 11956, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Amgad
authors.affiliation: Department of Surgery, Mayo Clinic, Rochester, Minnesota 55904, USA.
authors.forename: Amira A
authors.initials: AA
authors.lastname: Zayed
keywords: Th17 cells; angiogenesis; contact lenses; corneal neovascularization; dendritic cells; herpes simplex keratitis; keratoplasty; lymphangiogenesis; macrophage