title: Adhesive and robust multilayered poly(lactic acid) nanosheets for hemostatic dressing in liver injury model.
abstract: Freestanding biodegradable nanosheets composed of poly(l-lactic acid) (PLLA) have been developed for various biomedical applications. These nanosheets exhibit unique properties such as high adhesiveness and exquisite flexibility; however, they burst easily due to their nanometer thickness. We herein describe a freestanding, multilayered nanosheet composed of PLLA fabricated using a simple combination procedure: (i) multilayering of PLLA and alginate, (ii) gelation of the alginate layers, (iii) fusion-cut sealing, and (iv) elution of the alginate layers. The multilayered nanosheets not only reinforced the bursting strength but also provided a high level of adhesive strength. In fact, they were found to show potential as a hemostatic dressing, and they tended to show reduced tissue adhesion that accompanies liver injury. Therefore, we propose this biomaterial as a candidate for an alternative to conventional therapy in hemorrhage. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1747-1757, 2017.
authors.affiliation: Course of Industrial Chemistry, Graduate School of Engineering, Tokai University. 4-1-1 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Komachi
authors.affiliation: Department of Regenerative Medicine, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Sumiyoshi
authors.affiliation: Department of Regenerative Medicine, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Inagaki
authors.affiliation: Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University, TWIns, Tokyo, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Takeoka
authors.affiliation: Course of Industrial Chemistry, Graduate School of Engineering, Tokai University. 4-1-1 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Nagase
authors.affiliation: Course of Industrial Chemistry, Graduate School of Engineering, Tokai University. 4-1-1 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan.|Micro/Nano Technology Center, Tokai University. 4-1-1 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Okamura
mesh_terms: D000818:Animals; D006488:Hemostasis, Surgical / Q000295:instrumentation / Q000379:methods; D008099:Liver / Q000473:pathology / Q000601:surgery; D008297:Male; D009779:Occlusive Dressings; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014014:Tissue Adhesives / Q000737:chemistry / Q000494:pharmacology
chemical_list: D011091:Polyesters; D014014:Tissue Adhesives; C033616:poly(lactide)
keywords: hemostatic dressings; liver injury; multilayer; nanosheet; poly(lactic acid)