title: Regulatory mechanisms in arterial hypertension: role of microRNA in pathophysiology and therapy.
abstract: Multiple factors underlie the pathophysiology of hypertension, involving endothelial dysregulation, vascular smooth muscle dysfunction, increased oxidative stress, sympathetic nervous system activation and altered renin -angiotensin -aldosterone regulatory activity. A class of non-coding RNA called microRNA, consisting of 17-25 nucleotides, exert regulatory function over these processes. This paper summarizes the currently available data from preclinical and clinical studies on miRNA in the development of hypertension as well as the impact of anti-hypertensive treatment on their plasma expression. We present microRNAs' characteristics, their biogenesis and role in the regulation of blood pressure together with their potential diagnostic and therapeutic application in clinical practice.
authors.affiliation: a Division of Heart Failure and Cardiac Rehabilitation, Department of Cardiology, Hypertension and Internal Medicine, Second Faculty of Medicine , Medical University of Warsaw , Warsaw , Poland.|b Department of Immunology, Transplantology and Internal Diseases , Medical University of Warsaw , Warsaw , Poland.
authors.forename: Dominika
authors.initials: D
authors.lastname: Klimczak
authors.affiliation: c Genomic Medicine , Medical University of Warsaw , Warsaw , Poland.|d Laboratory of Human Cancer Genetics, Centre of New Technologies, CENT , University of Warsaw , Warsaw , Poland.
authors.forename: Krystian
authors.initials: K
authors.lastname: Jazdzewski
authors.affiliation: e Department of Cardiology, Hypertension and Internal Medicine, Second Faculty of Medicine , Medical University of Warsaw , Warsaw , Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Kuch
mesh_terms: D000818:Animals; D006801:Humans; D006973:Hypertension / Q000378:metabolism* / Q000503:physiopathology* / Q000628:therapy*; D035683:MicroRNAs / Q000378:metabolism*; D012084:Renin-Angiotensin System
chemical_list: D035683:MicroRNAs
keywords: Enodthelium; hypertension; microRNA, regulation, renin–angiotnesin–aldosterone system