title: Quantitative PET Imaging Using (18)F Sodium Fluoride in the Assessment of Metabolic Bone Diseases and the Monitoring of Their Response to Therapy.
abstract: Studies of bone remodeling using bone biopsy and biochemical markers of bone turnover measured in serum and urine are important for investigating how new treatments for osteoporosis affect bone metabolism. Positron emission tomography with (18)F sodium fluoride ((18)F NaF PET) for studying bone metabolism complements these conventional methods. Unlike biochemical markers, which measure the integrated response to treatment across the whole skeleton, (18)F NaF PET can distinguish changes occurring at sites of clinically important osteoporotic fractures. Future studies using (18)F NaF PET may illuminate current clinical problems, such as the possible association between long-term treatment with bisphosphonates and atypical fractures of the femur.
authors.affiliation: Osteoporosis Unit, King's College London, King's Health Partners, Guy's Hospital, London SE1 9RT, UK.
authors.forename: Glen M
authors.initials: GM
authors.lastname: Blake
authors.affiliation: Osteoporosis Unit, King's College London, King's Health Partners, Guy's Hospital, London SE1 9RT, UK.
authors.forename: Musib
authors.initials: M
authors.lastname: Siddique
authors.affiliation: Osteoporosis Unit, King's College London, King's Health Partners, Guy's Hospital, London SE1 9RT, UK.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Frost
authors.affiliation: Osteoporosis Unit, King's College London, King's Health Partners, Guy's Hospital, London SE1 9RT, UK.
authors.forename: Amelia E B
authors.initials: AE
authors.lastname: Moore
authors.affiliation: Department of Nuclear Medicine, King's College London, King's Health Partners, Guy's Hospital, London SE1 9RT, UK.
authors.forename: Ignac
authors.initials: I
authors.lastname: Fogelman