title: Participation of oleic acid in the formation of the aortic aneurysm in Marfan syndrome patients.
abstract: Marfan syndrome (MFS) is associated with progressive aortic dilatation and endothelial dysfunction that lead to early acute dissection and rupture of the aorta and sudden death. Alteration in fatty acid (FA) metabolism can stimulate nitric oxide (NO) overproduction which increases the activity of the inducible form of NO synthase (iNOS) that is involved in endothelial dysfunction. We evaluated the participation of FA in the formation of thoracic aneurysms in MFS and its relation to the iNOS. Oleic acid (OA), iNOS, citrulline, nitrates and nitrites, TGF-β1, TNF-α, monounsaturated FA and NO synthase activity were significantly increased (p<0.05) in tissue from the aortas of MFS. Saturated FA, eNOS and HDL were significantly decreased (p<0.05). Arachidonic acid, delta-9 desaturase tended to increase and histological examination showed an increase in cystic necrosis, elastic fibers and collagen in MFS. The increase in OA contributes to the altered pathway of iNOS, which favors endothelial dysfunction and formation of the aortic aneurysms in MFS.
authors.affiliation: Department of Immunology, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Sección XVI, Tlalpan, 14080 México City, DF, Mexico.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Soto
authors.affiliation: Department of Cardiothoracic Surgery, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Sección XVI, Tlalpan, 14080 México City, DF, Mexico.
authors.forename: Alejandra Valeria
authors.initials: AV
authors.lastname: Iturriaga Hernández
authors.affiliation: Department of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Sección XVI, Tlalpan, 14080 México City, DF, Mexico.
authors.forename: Verónica
authors.initials: V
authors.lastname: Guarner Lans
authors.affiliation: Department of Pathology, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Sección XVI, Tlalpan, 14080 México City, DF, Mexico.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Zuñiga-Muñoz
authors.affiliation: Department of Pathology, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Sección XVI, Tlalpan, 14080 México City, DF, Mexico.
authors.forename: Alberto
authors.initials: A
authors.lastname: Aranda Fraustro
authors.affiliation: Department of Pathology, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Sección XVI, Tlalpan, 14080 México City, DF, Mexico.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Velázquez Espejel
authors.affiliation: Department of Pathology, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano 1, Sección XVI, Tlalpan, 14080 México City, DF, Mexico. Electronic address: pertorisr@yahoo.com.mx.
authors.forename: Israel
authors.initials: I
authors.lastname: Pérez-Torres
mesh_terms: D000328:Adult; D001011:Aorta / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D001014:Aortic Aneurysm / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D016718:Arachidonic Acid / Q000378:metabolism; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000378:metabolism; D002956:Citrulline / Q000378:metabolism; D003094:Collagen / Q000235:genetics / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009566:Nitrates / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000235:genetics / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000235:genetics / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D019301:Oleic Acid / Q000378:metabolism*; D011446:Prospective Studies; D015398:Signal Transduction; D013230:Stearoyl-CoA Desaturase / Q000235:genetics / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: D008076:Cholesterol, HDL; D009566:Nitrates; D009573:Nitrites; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D016718:Arachidonic Acid; D002956:Citrulline; D019301:Oleic Acid; D003094:Collagen; C496319:NOS2 protein, human; C496314:NOS3 protein, human; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; D013230:Stearoyl-CoA Desaturase
keywords: Aneurysm; Fatty acids; Inducible nitric oxide synthase; Marfan syndrome; Nitric oxide; Oleic acid