title: Second Messenger-Operated Calcium Entry Through TRPC6.
abstract: Canonical transient receptor potential 6 (TRPC6) proteins assemble into heteromultimeric structures forming non-selective cation channels. In addition, many TRPC6-interacting proteins have been identified like some enzymes, channels, pumps, cytoskeleton-associated proteins, immunophilins, or cholesterol-binding proteins, indicating that TRPC6 are engaged into macromolecular complexes. Depending on the cell type and the experimental conditions used, TRPC6 activity has been reported to be controlled by diverse modalities. For instance, the second messenger diacylglycerol, store-depletion, the plant extract hyperforin or H2O2 have all been shown to trigger the opening of TRPC6 channels. A well-characterized consequence of TRPC6 activation is the elevation of the cytosolic concentration of Ca(2+). This latter response can reflect the entry of Ca(2+) through open TRPC6 channels but it can also be due to the Na(+)/Ca(2+) exchanger (operating in its reverse mode) or voltage-gated Ca(2+) channels (recruited in response to a TRPC6-mediated depolarization). Although TRPC6 controls a diverse array of biological functions in many tissues and cell types, its pathophysiological functions are far from being fully understood. This chapter covers some key features of TRPC6, with a special emphasis on their biological significance in kidney and blood cells.
authors.affiliation: Université Grenoble Alpes, 38000, Grenoble, France. alexandre.bouron@cea.fr.|CNRS, iRTSV-LCBM, 38000, Grenoble, France. alexandre.bouron@cea.fr.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bouron
authors.affiliation: Université Grenoble Alpes, 38000, Grenoble, France.|CNRS, iRTSV-LCBM, 38000, Grenoble, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Chauvet
authors.affiliation: University of Houston, Houston, TX, USA.|Baylor College of Medicine, Houston, TX, USA.
authors.forename: Stuart
authors.initials: S
authors.lastname: Dryer
authors.affiliation: Departamento de Fisiología, University of Extremadura, Cáceres, Spain.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Rosado
mesh_terms: D002118:Calcium / Q000378:metabolism*; D006801:Humans; D017136:Ion Transport; D015290:Second Messenger Systems; D050052:TRPC Cation Channels / Q000378:metabolism*; D000074287:TRPC6 Cation Channel
chemical_list: D050052:TRPC Cation Channels; D000074287:TRPC6 Cation Channel; C117032:TRPC6 protein, human; D002118:Calcium
keywords: Blood cells; Ca2+ entry; DAG; Kidney; TRPC6