title: Antibiotics and RNase P.
abstract: RNase P is an essential endonuclease in tRNA biogenesis, which generates the mature 5'-termini of tRNAs. Most forms of RNase P are ribonucleoproteins, i.e., they consist of an essential RNA and protein subunits. The catalytic function of ribonucleoprotein RNase P enzymes resides entirely in the RNA subunit. Its high structural and functional diversity among representatives of a vast variety of phylogenetic domains indicates that RNase P could serve as a molecular target and a useful screening system for the development of new drugs in the battle against bacterial drug resistance.
authors.affiliation: Department of Biological Chemistry, School of Medicine, University of Patras, Rio-Patras 26504, Greece. drainas@med.upatras.gr.
authors.forename: Denis
authors.initials: D
authors.lastname: Drainas
keywords: RNase P; morpholino oligonucleotides; neomycin B; neomycin sulfate; puromycin