title: Evaluation of wireless stimulation of the endocardium, WiSE, technology for treatment heart failure.
abstract: BACKGROUND
  There are several unsolved limitations in delivering cardiac resynchronization therapy. 30-40% of patients fail to have any clinical benefit after 6 months caused by different reasons.
  
  
  METHODS
  Endocardial stimulation rather than conventional epicardial pacing has been shown to: be more physiologically, improve electrical stimulation of the left ventricular, give less dispersion of repolarisation and result in better resynchronization. The Wireless Cardiac Stimulation in Left Ventricle, WiCS-LV, system provides an option for wireless, left ventricular endocardial pacing triggered from a conventional right ventricular pacing spike from a co-implant. Expert commentary: The feasibility of the WiCS-LV system has been successfully demonstrated in a population of failed cardiac resynchronization patients, either failed implantation procedure of a conventional system, non-responder to conventional therapy or upgrade from pacemaker or defibrillator, where a conventional system was not an option. WiCS-LV is innovative technology with promising safety, performance and preliminary efficacy.
authors.affiliation: a Department of Cardiology , Heart Centre Brandenburg, Medical School Brandenburg , Bernau/Berlin , Germany.
authors.forename: M
authors.initials: M
authors.lastname: Seifert
authors.affiliation: a Department of Cardiology , Heart Centre Brandenburg, Medical School Brandenburg , Bernau/Berlin , Germany.
authors.forename: C
authors.initials: C
authors.lastname: Butter
mesh_terms: D058406:Cardiac Resynchronization Therapy / Q000379:methods*; D058409:Cardiac Resynchronization Therapy Devices; D004699:Endocardium / Q000503:physiopathology*; D006333:Heart Failure / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D059015:Wireless Technology / Q000295:instrumentation*
keywords: Cardiac resynchronization therapy implantation; heart failure; leadless left ventricular endocardial pacing; ultrasound energy transfer