title: Palladium-Catalyzed Directed para C-H Functionalization of Phenols.
abstract: Various practical methods for the selective C-H functionalization of the ortho and recently also of the meta position of an arene have already been developed. Following our recent development of the directing-group-assisted para C-H functionalization of toluene derivatives, we herein report the first remote para C-H functionalization of phenol derivatives by using a recyclable silicon-containing biphenyl-based template. The effectiveness of this strategy was illustrated with different synthetic elaborations and by the synthesis of various phenol-based natural products.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
authors.forename: Tuhin
authors.initials: T
authors.lastname: Patra
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
authors.forename: Sukdev
authors.initials: S
authors.lastname: Bag
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kancherla
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Mondal
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Dey
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Pimparkar
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
authors.forename: Soumitra
authors.initials: S
authors.lastname: Agasti
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
authors.forename: Atanu
authors.initials: A
authors.lastname: Modak
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India. dmaiti@chem.iitb.ac.in.
authors.forename: Debabrata
authors.initials: D
authors.lastname: Maiti
keywords: C−H activation; olefination; palladium; silicon; synthetic methods