title: The cumulative effect of bisphosphonates and statins on stress fractures. Is it a failure of steroid biosynthesis? Case Report.
abstract: Osteoporosis related fractures pose a significant economic and healthcare problem. There is a growing concern about increased numbers of stress or low energy fractures after bisphosphonates therapy. A 65-year-old woman is presented with a stress fracture of the left femur. From our point of view, this fracture was associated with a long-term statin and bisphosphonate therapy. We did not find a similar presentation in medical literature.
authors.affiliation: Department of Orthopaedic Surgery, Hattiesburg Clinic, Hattiesburg, MS, USA.
authors.forename: Sergey S
authors.initials: SS
authors.lastname: Dzugan
authors.affiliation: Dzugan Institute of Restorative Medicine, Deerfield Beach, FL, USA.
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Dzugan
mesh_terms: D000368:Aged; D050071:Bone Density Conservation Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004164:Diphosphonates / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005264:Femoral Fractures / Q000175:diagnosis / Q000209:etiology*; D015775:Fractures, Stress / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D010024:Osteoporosis / Q000188:drug therapy
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors