title: Platelet Gel in a Non-Regenerating Cryosurgery-Induced Skin Wound in an Old Patient: A Case Report.
abstract: OBJECTIVE
  To report on the clinical benefits of platelet gel application in a non-regenerating skin wound.
  
  
  METHODS
  An 84-year-old man presented with a severe wound with a regular circumference in the frontal region which resulted in a complete loss of epidermis and dermis. The skin lesion, induced by cryosurgery used to remove a basal-cell carcinoma, had previously been treated with a dermal substitute application (Integra®). After the failure of the skin graft, the patient was treated using a platelet gel therapeutic protocol which achieved the complete healing of the injured area.
  
  
  CONCLUSIONS
  This case showed the clinical efficacy of using platelet gel in this elderly patient in whom the dermal substitute graft had been ineffective.
authors.affiliation: Unitx00E0; Operativa Complessa, Clinical Immunology, Immunohematology, Transfusion Medicine and Transplant Immunology, Regional Reference Laboratory of Transplant Immunology, Department of Internal Medicine and Specialistic Unit, Azienda Ospedaliera Universitaria, Second University of Naples, Naples, Italy.
authors.forename: Orlando
authors.initials: O
authors.lastname: Pignalosa
authors.forename: Dario
authors.initials: D
authors.lastname: Martusciello
authors.forename: Maria R
authors.initials: MR
authors.lastname: De Pascale
authors.forename: Linda
authors.initials: L
authors.lastname: Sommese
authors.forename: Giovanni F
authors.initials: GF
authors.lastname: Nicoletti
authors.forename: Angelo
authors.initials: A
authors.lastname: Itro
authors.forename: Francesco
authors.initials: F
authors.lastname: Cavalca
authors.forename: Gianpaolo
authors.initials: G
authors.lastname: Tartaro
authors.forename: Claudio
authors.initials: C
authors.lastname: Napoli
mesh_terms: D000369:Aged, 80 and over; D001792:Blood Platelets; D003452:Cryosurgery / Q000009:adverse effects; D005782:Gels / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D017768:Skin, Artificial; D014947:Wounds and Injuries / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D005782:Gels