title: Alloimmunity and Tolerance in Corneal Transplantation.
abstract: Corneal transplantation is one of the most prevalent and successful forms of solid tissue transplantation. Despite favorable outcomes, immune-mediated graft rejection remains the major cause of corneal allograft failure. Although low-risk graft recipients with uninflamed graft beds enjoy a success rate ∼90%, the rejection rates in inflamed graft beds or high-risk recipients often exceed 50%, despite maximal immune suppression. In this review, we discuss the critical facets of corneal alloimmunity, including immune and angiogenic privilege, mechanisms of allosensitization, cellular and molecular mediators of graft rejection, and allotolerance induction.
authors.affiliation: Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114.
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Amouzegar
authors.affiliation: Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114 sunil_chauhan@meei.harvard.edu reza_dana@meei.harvard.edu.
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Chauhan
authors.affiliation: Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114 sunil_chauhan@meei.harvard.edu reza_dana@meei.harvard.edu.
authors.forename: Reza
authors.initials: R
authors.lastname: Dana
mesh_terms: D043925:Angiogenesis Inducing Agents; D000818:Animals; D016039:Corneal Transplantation; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D007249:Inflammation / Q000276:immunology*; D007519:Isoantigens / Q000276:immunology; D012306:Risk; D014181:Transplantation Immunology
chemical_list: D043925:Angiogenesis Inducing Agents; D007519:Isoantigens