title: Application of cellulose acetate for controlled release of thymol.
abstract: Cellulose acetate (CA) was investigated as a carrier towards development of material with controlled release of thymol as a natural substance with strong antibacterial properties using high pressure techniques. Effect of thymol content on CA was confirmed by SEM, FTIR and DSC methods. Kinetic of thymol release from CA was tested using simulated gastric and intestinal fluids (hydrochloric acid and phosphate buffer saline). Results were correlated with Korsmeyer-Peppas and Weibull model. Depending on the thymol content and chemical nature of the release medium, the time of thymol release varied from one to three days indicating CA as a promising carrier of thymol with potential uses from medicine to agriculture. The impregnated CA showed antibacterial activity against 23 tested bacterial strains including methicillin-resistant Staphylococcus aureus (MRSA) which is particularly important bearing in mind that this strain causes fatal infections in humans and animals.
authors.affiliation: University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia. Electronic address: smilovanovic@tmf.bg.ac.rs.
authors.forename: Stoja
authors.initials: S
authors.lastname: Milovanovic
authors.affiliation: University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia.
authors.forename: Darka
authors.initials: D
authors.lastname: Markovic
authors.affiliation: University of Belgrade, Faculty of Veterinary Medicine, Bulevar oslobodjenja 18, 11000 Belgrade, Serbia.
authors.forename: Ksenija
authors.initials: K
authors.lastname: Aksentijevic
authors.affiliation: University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia.
authors.forename: Dusica B
authors.initials: DB
authors.lastname: Stojanovic
authors.affiliation: University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia.
authors.forename: Jasna
authors.initials: J
authors.lastname: Ivanovic
authors.affiliation: University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia.
authors.forename: Irena
authors.initials: I
authors.lastname: Zizovic
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy*; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000494:pharmacology; D004337:Drug Carriers / Q000008:administration & dosage / Q000592:standards; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013943:Thymol / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; C005062:acetylcellulose; D013943:Thymol; D002482:Cellulose
keywords: Antibacterial activity; Cellulose acetate; Controlled release; Supercritical impregnation; Thymol