title: EVALUATIN OF ANTIHYPERTENSIVE ACTIVITY OF SONCHUS ASPER L. IN RATS.
abstract: The present investigation was carried out to evaluate the effect of aerial parts of Sonchus asper L. in normotensive, glucose and egg feed diet induced hypertensive rats. Aqueous-methanolic extract of Sonchus asper in 250, 500 and 1000 mg/kg doses was studied in normotensive and glucose induced hypertensive rats using the non-invasive technique. The results obtained showed that the extract has significantly (p < 0.5 - p < 0.001) decreased the blood pressure and heart rate in dose dependent manner. The dose 1000 mg/kg of the extract produced the maximum antihypertensive effect and was selected for further experiments. The extract was found to prevent the rise in blood pressure of egg and glucose fed rats as compared to control group in 21 days study. The LD50 of the plant extract was 3500 mg/kg b.w. in mice and sub-chronic toxicity study showed that there was no significant alteration in the blood chemistry of the extract treated rats. It is conceivable, therefore, that the aqueous-methanolic extract of Sonchus asper has exerted considerable antihypertensive activity in rats and has duly supported traditional medicinal use of plant in hypertension.
authors.forename: Muhammad Naveed
authors.initials: MN
authors.lastname: Mushtaq
authors.forename: Muhammad Shoaib
authors.initials: MS
authors.lastname: Akhtar
authors.lastname: Alamgeer
authors.forename: Taseer
authors.initials: T
authors.lastname: Ahmad
authors.forename: Hafeez Ullah
authors.initials: HU
authors.lastname: Khan
authors.forename: Safirah
authors.initials: S
authors.lastname: Maheen
authors.forename: Haseeb
authors.initials: H
authors.lastname: Ahsan
authors.forename: Huma
authors.initials: H
authors.lastname: Naz
authors.forename: Hira
authors.initials: H
authors.lastname: Asif
authors.forename: Waqas
authors.initials: W
authors.lastname: Younis
authors.forename: Nazia
authors.initials: N
authors.lastname: Tabassum
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects*; D004032:Diet; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D007928:Lethal Dose 50; D000432:Methanol / Q000737:chemistry; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal; D017207:Rats, Sprague-Dawley; D012997:Solvents / Q000737:chemistry; D031184:Sonchus / Q000737:chemistry
chemical_list: D000959:Antihypertensive Agents; D010936:Plant Extracts; D012997:Solvents; D000432:Methanol