title: Impact of pharmaceutical intervention on quality of life and coping strategies in patients with haematological malignancies.
abstract: OBJECTIVE
  We conducted a prospective study approved by the local ethics committee to determine the impact of a pharmaceutical intervention (PI) on pain, fatigue, quality of life (QoL) and coping strategies in patients with HMs starting chemotherapy sessions.
  
  
  METHODS
  Patients received either usual care (UC)+PI (PI group) or UC alone (UC group). They had to complete 2 questionnaires, QLQ-C30 and MAC 21, at 3 different time points: before starting the 1st chemotherapy session (T1), during the intercure (T2) and the day before starting the 2nd chemotherapy session (T3). To determine predictive factors of pain, fatigue, QoL and coping scores at T3, a multivariate ANOVA was used. QoL and coping scores were analysed longitudinally using a linear mixed model.
  
  
  RESULTS
  Sixty-eight patients were included in the PI (n=34) or UC groups (n=34). Ninety-two percent of the patients returned all the questionnaires. At inclusion, QoL was significantly better in the PI group (P=0.047). At T3, the group had no influence on pain, fatigue, nor coping scores but a trend towards a better QoL was observed in the PI group (P=0.090). Longitudinally, the PI group did not present significantly better scores on pain, fatigue but both a trend toward better Qol scores and lower anxious preoccupations scores.
  
  
  CONCLUSIONS
  A PI at the beginning of chemotherapy sessions did not have any significant impact on pain and fatigue but a trend towards better Qol scores and lower anxious preoccupations scores.
authors.affiliation: Department of Pharmacy, University Hospital, 14, rue Gaffarel, 21000 Dijon, France.
authors.forename: M-A
authors.initials: MA
authors.lastname: Opsomer
authors.affiliation: Methodology and quality of Life in Oncology unit (EA 3181) & quality of Life and cancer clinical research platform, University Hospital, 25000 Besançon, France.
authors.forename: A
authors.initials: A
authors.lastname: Anota
authors.affiliation: Department of Pharmacy, University Hospital, 14, rue Gaffarel, 21000 Dijon, France.
authors.forename: M
authors.initials: M
authors.lastname: Noblot-Rossignol
authors.affiliation: Methodology and quality of Life in Oncology unit (EA 3181) & quality of Life and cancer clinical research platform, University Hospital, 25000 Besançon, France.
authors.forename: F
authors.initials: F
authors.lastname: Bonnetain
authors.affiliation: Department of Pharmacy, University Hospital, 14, rue Gaffarel, 21000 Dijon, France.
authors.forename: C
authors.initials: C
authors.lastname: Pernot
authors.affiliation: Department of Haematology, University Hospital, 21000 Dijon, France.
authors.forename: M-L
authors.initials: ML
authors.lastname: Chretien
authors.affiliation: Department of Haematology, University Hospital, 21000 Dijon, France.
authors.forename: C
authors.initials: C
authors.lastname: Legouge
authors.affiliation: Department of Haematology, University Hospital, 21000 Dijon, France.
authors.forename: D
authors.initials: D
authors.lastname: Caillot
authors.affiliation: Department of Pharmacy, University Hospital, 14, rue Gaffarel, 21000 Dijon, France; EA 4184, University of Burgundy, 21000 Dijon, France. Electronic address: mathieu.boulin@chu-dijon.fr.
authors.forename: M
authors.initials: M
authors.lastname: Boulin
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018763:Muscle Fatigue / Q000187:drug effects; D010595:Pharmacists; D011446:Prospective Studies; D011788:Quality of Life; D012017:Referral and Consultation; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents
keywords: Chemotherapy; Chimiothérapie; Coping strategies; Haematology; Hématologie; Intervention pharmaceutique; Pharmaceutical intervention; Quality of life; Qualité de vie; Stratégies d’adaptation