title: Transfusion-related acute lung injury in an era of TRALI risk mitigation.
abstract: Transfusion-related acute lung injury (TRALI) is a rare complication of transfusion, for which the true incidence remains obscure, since there are a number of factors that may lead to misdiagnosis. Despite this, it continues to be the leading cause of transfusion-associated mortality. Here we present a historical case of TRALI in an elderly female who received group AB plasma and discuss how current mitigation strategies would likely have prevented its occurrence. It is important to remember that both immune and non-immune factors play a role in TRALI pathogenesis, and although current preventative strategies may decrease TRALI's incidence, they likely will not eliminate it.
authors.affiliation: Transfusion Medicine Fellow 2014-2015.
authors.forename: John C
authors.initials: JC
authors.lastname: Lavelle
authors.affiliation: Transfusion Medicine Fellow 2015-2016.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Grant
authors.affiliation: Assistant Professor, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University Hospital, 111 S. 11th Street, Gibbon 8220, Philadelphia, PA 19107.
authors.forename: Julie K
authors.initials: JK
authors.lastname: Karp
mesh_terms: D055371:Acute Lung Injury; D000368:Aged; D005260:Female; D006801:Humans; D065227:Transfusion Reaction