title: Pre-LTP requires extracellular signal-regulated kinase in the ACC.
abstract: The extracellular signal-regulated kinase is an important protein kinase for cortical plasticity. Long-term potentiation in the anterior cingulate cortex is believed to play important roles in chronic pain, fear, and anxiety. Previous studies of extracellular signal-regulated kinase are mainly focused on postsynaptic form of long-term potentiation (post-long-term potentiation). Little is known about the relationship between extracellular signal-regulated kinase and presynaptic long-term potentiation (pre-long-term potentiation) in cortical synapses. In this study, we examined whether pre-long-term potentiation in the anterior cingulate cortex requires the activation of presynaptic extracellular signal-regulated kinase. We found that p42/p44 mitogen-activated protein kinase inhibitors, PD98059 and U0126, suppressed the induction of pre-long-term potentiation. By contrast, these inhibitors did not affect the maintenance of pre-long-term potentiation. Using pharmacological inhibitors, we found that pre-long-term potentiation recorded for 1 h did not require transcriptional or translational processes. Our results strongly indicate that the activation of presynaptic extracellular signal-regulated kinase is required for the induction of pre-long-term potentiation, and this involvement may explain the contribution of extracellular signal-regulated kinase to mood disorders.
authors.affiliation: Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi'an Jiaotong University, Shanxi, China Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada.
authors.forename: Manabu
authors.initials: M
authors.lastname: Yamanaka
authors.affiliation: Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi'an Jiaotong University, Shanxi, China Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Tian
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada.
authors.forename: Soroush
authors.initials: S
authors.lastname: Darvish-Ghane
authors.affiliation: Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi'an Jiaotong University, Shanxi, China Department of Physiology, Faculty of Medicine, University of Toronto, Ontario, Canada min.zhuo@utoronto.ca.
authors.forename: Min
authors.initials: M
authors.lastname: Zhuo
mesh_terms: D000818:Animals; D002070:Butadienes / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D005419:Flavonoids / Q000494:pharmacology; D018698:Glutamic Acid / Q000378:metabolism; D006179:Gyrus Cinguli / Q000187:drug effects / Q000201:enzymology* / Q000502:physiology*; D017774:Long-Term Potentiation / Q000187:drug effects; D008810:Mice, Inbred C57BL; D020929:Mitogen-Activated Protein Kinase Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D009570:Nitriles / Q000494:pharmacology; D014176:Protein Biosynthesis / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D002070:Butadienes; D005419:Flavonoids; D009570:Nitriles; D047428:Protein Kinase Inhibitors; C113580:U 0126; D018698:Glutamic Acid; D048049:Extracellular Signal-Regulated MAP Kinases; D020929:Mitogen-Activated Protein Kinase Kinases; C093973:2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
keywords: ERK; LTP; anterior cingulate cortex; mouse; presynaptic release