title: Determination of 50% endpoint titer using a simple formula.
abstract: Two commonly used methods for calculating 50% endpoint using serial dilutions are Spearman-Karber method and Reed and Muench method. To understand/apply the above formulas, moderate statistical/mathematical skills are necessary. In this paper, a simple formula/method for calculating 50% endpoints has been proposed. The formula yields essentially similar results as those of the Spearman-Karber method. The formula has been rigorously evaluated with several samples.
authors.affiliation: Muthannan Andavar Ramakrishnan, Division of Virology, Indian Veterinary Research Institute, Uttarakhand 263138, India.
authors.forename: Muthannan Andavar
authors.initials: MA
authors.lastname: Ramakrishnan
keywords: Endpoint dilution; Reed and Muench; Spearman-Karber; TCID50