title: Microbiota and the nitrogen cycle: Implications in the development and progression of CVD and CKD.
abstract: Chronic kidney disease (CKD) is associated with an increased risk of death from cardiovascular disease (CVD). One factor involved in CVD development is nitric oxide (NO), which acts as a powerful vasodilator. NO is produced via the nitrogen cycle, through the reduction of nitrate to nitrite with the process mainly occurring in the mouth by commensal microbiota. People with CKD have compromised microbiota (dysbiosis) with an increased abundance of potentially pathogenic and pro-inflammatory bacteria capable of producing uremic toxins that contribute to CKD development and reduce enzymatic NO production. However, to date, few studies have comprehensively documented the gut or saliva microbiota in the CKD population or investigated the role of NO in people with CKD. This review will discuss NO pathways that are linked to the progression of CKD and CVD and therapeutic options for targeting these pathways.
authors.affiliation: School of Human Movement and Nutrition Sciences, University of Queensland, St Lucia, Australia. Electronic address: d.briskey@uq.edu.au.
authors.forename: David
authors.initials: D
authors.lastname: Briskey
authors.affiliation: Clinical Biochemistry Laboratory, Central Queensland University, Rockhampton, Australia.
authors.forename: Patrick S
authors.initials: PS
authors.lastname: Tucker
authors.affiliation: Centre for Kidney Disease Research, School of Medicine, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia.
authors.forename: David W
authors.initials: DW
authors.lastname: Johnson
authors.affiliation: School of Human Movement and Nutrition Sciences, University of Queensland, St Lucia, Australia.
authors.forename: Jeff S
authors.initials: JS
authors.lastname: Coombes
mesh_terms: D000641:Ammonia / Q000378:metabolism; D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism* / Q000382:microbiology; D018450:Disease Progression; D064806:Dysbiosis / Q000150:complications / Q000378:metabolism; D006801:Humans; D064307:Microbiota / Q000502:physiology*; D009566:Nitrates / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis; D009573:Nitrites / Q000378:metabolism; D058458:Nitrogen Cycle / Q000187:drug effects / Q000502:physiology*; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000188:drug therapy / Q000378:metabolism* / Q000382:microbiology
chemical_list: D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D000641:Ammonia
keywords: Cardiovascular disease; Chronic kidney disease; Microbiota; Nitrate; Nitric oxide; Nitrite