title: Systemic lupus erythematosus and renal tubular acidosis associated with hyperthyroidism. Case Report.
abstract: A case of a 42-year-old female with hyperthyroidism was subsequently diagnosed to have systemic lupus erythematosus with distal RTA. The clinical examination on admission showed swelling of the knee joints and the urinalysis showed pH 6.5, pro 3+. Her blood routine results were as follows: white blood cells 1.85×109/L, platelets 100×109/L, erythrocyte 3.06×1012/L. The serum potassium was 3.11 mmol/L, 24 hour urinary electrolyte: K 68.87 mmol/24 H, antinuclear antibodies (ANA) 1:1 000, speckled pattern. The anti-double stranded DNA antibody (anti-dsDNA), anti SS-A(52) antibody and anti SS-A(60) antibody were positive. The light microscopy and immunofluorescence showed diffuse proliferative lupus nephritis. These data were compatible with the diagnosis of systemic lupus erythematosus. The diagnosis of hyperthyroidism and distal RTA is clear. This report showed that other autoimmune disease in the diagnosis of hyperthyroidism should not be ignored.
authors.affiliation: Department of Endocrinology, Institute of Endocrinology and Metabolism, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Datong
authors.initials: D
authors.lastname: Deng
authors.affiliation: Department of Endocrinology, Institute of Endocrinology and Metabolism, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Endocrinology, Institute of Endocrinology and Metabolism, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Tongjia
authors.initials: T
authors.lastname: Xia
authors.affiliation: Department of Endocrinology, Institute of Endocrinology and Metabolism, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Institute of Endocrinology and Metabolism, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Youmin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Institute of Endocrinology and Metabolism, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000141:Acidosis, Renal Tubular / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D000328:Adult; D004247:DNA / Q000276:immunology; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D007686:Kidney Tubules, Distal / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D008181:Lupus Nephritis / Q000150:complications / Q000473:pathology / Q000628:therapy
chemical_list: D004247:DNA