title: Donor Safety in Adult-Adult Living Donor Liver Transplantation: A Single-Center Experience of 356 Cases.
abstract: BACKGROUND As an important means to tackle the worldwide shortage of liver grafts, adult-adult living donor liver transplantation (A-ALDLT) is the most massive operation a healthy person could undergo, so donor safety is of prime importance. However, most previous research focused on recipients, while complications in donors have not been fully described or investigated. MATERIAL AND METHODS To investigate donor safety in terms of postoperative complications, the clinical data of 356 A-ALDLT donors in our center from January 2002 to September 2015 were retrospectively analyzed. These patients were divided into a pre-2008 group (before January 2008) and a post-2008 group (after January 2008). Donor safety was evaluated with regard to the type, frequency, and severity of postoperative complications. RESULTS There were no donor deaths in our center during this period. The overall complication rate was 23.0% (82/356). The proportion of Clavien I, II, III, and IV complications was 51.2% (42/82), 25.6% (21/82), 22.0% (18/82), and 1.2% (1/82), respectively. In all the donors, the incidence of Clavien I, II, III, and IV complications was 11.8% (42/356), 5.9% (21/356), 5.1% (18/356), and 0.3% (1/356), respectively. The overall complication rate in the post-2008 group was significantly lower than that in the pre-2008 group (18.1% (41/227) vs. 32.6% (42/129), P<0.01). Biliary complications were the most common, with an incidence of 8.4% (30/356). CONCLUSIONS The risk to A-ALDLT donors is controllable and acceptable with improvement in preoperative assessment and liver surgery.
authors.affiliation: Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Haipeng
authors.initials: H
authors.lastname: Meng
authors.affiliation: Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Jiayin
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Lunan
authors.initials: L
authors.lastname: Yan
mesh_terms: D000328:Adult; D005260:Female; D006498:Hepatectomy; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods / Q000592:standards*; D019520:Living Donors; D008297:Male; D061214:Patient Safety; D011183:Postoperative Complications / Q000209:etiology; D012189:Retrospective Studies