title: Glass formability in medium-sized molecular systems/pharmaceuticals. I. Thermodynamics vs. kinetics.
abstract: Scrutinizing critical thermodynamic and kinetic factors for glass formation and the glass stability of materials would benefit the screening of the glass formers for the industry of glassy materials. The present work aims at elucidating the factors that contribute to the glass formation by investigating medium-sized molecules of pharmaceuticals. Glass transition related thermodynamics and kinetics are performed on the pharmaceuticals using calorimetric, dielectric, and viscosity measurements. The characteristic thermodynamic and kinetic parameters of glass transition are found to reproduce the relations established for small-molecule glass formers. The systematic comparison of the thermodynamic and kinetic contributions to glass formation reveals that the melting-point viscosity is the crucial quantity for the glass formation. Of more interest is the finding of a rough correlation between the melting-point viscosity and the entropy of fusion normalized by the number of beads of the pharmaceuticals, suggesting the thermodynamics can partly manifest its contribution to glass formation via kinetics.
authors.affiliation: State Key Lab of Metastable Materials Science and Technology, and College of Materials Science and Engineering, Yanshan University, Qinhuangdao, Hebei 066004, China.
authors.forename: Wenkang
authors.initials: W
authors.lastname: Tu
authors.affiliation: State Key Lab of Metastable Materials Science and Technology, and College of Materials Science and Engineering, Yanshan University, Qinhuangdao, Hebei 066004, China.
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Lab of Metastable Materials Science and Technology, and College of Materials Science and Engineering, Yanshan University, Qinhuangdao, Hebei 066004, China.
authors.forename: Zeming
authors.initials: Z
authors.lastname: Chen
authors.affiliation: State Key Lab of Metastable Materials Science and Technology, and College of Materials Science and Engineering, Yanshan University, Qinhuangdao, Hebei 066004, China.
authors.forename: Ying Dan
authors.initials: YD
authors.lastname: Liu
authors.affiliation: CNR-IPCF, Sede Secondaria Pisa, Largo Pontecorvo 3, I-56127 Pisa, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Labardi
authors.affiliation: CNR-IPCF, Sede Secondaria Pisa, Largo Pontecorvo 3, I-56127 Pisa, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Capaccioli
authors.affiliation: Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Paluch
authors.affiliation: State Key Lab of Metastable Materials Science and Technology, and College of Materials Science and Engineering, Yanshan University, Qinhuangdao, Hebei 066004, China.
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Wang
mesh_terms: D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D005898:Glass / Q000737:chemistry*; D007700:Kinetics; D010316:Particle Size; D013816:Thermodynamics