title: Significance of oncogenes and tumor suppressor genes in AML prognosis.
abstract: Acute myeloid leukemia (AML) is a heterogeneous disorder among hematologic malignancies. Several genetic alterations occur in this disease, which cause proliferative progression, reducing differentiation and apoptosis in leukemic cells as well as increasing their survival. In the genetic study of AML, genetic translocations, gene overexpression, and mutations effective upon biology and pathogenesis of this disease have been recognized. Proto-oncogenes and tumor suppressor genes, which are important in normal development of myeloid cells, are involved in the regulation of cell cycle and apoptosis, undergo mutation in this type of leukemia, and are effective in prognosis of AML subtypes. This review deals with these genes, the assessment of which can be important in the diagnosis and prognosis of patients as well as therapeutic outcome.
authors.affiliation: Health research institute, Thalassemia & Hemoglobinopathy Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Maria
authors.initials: M
authors.lastname: Kavianpour
authors.affiliation: Health research institute, Thalassemia & Hemoglobinopathy Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Ahmadzadeh
authors.affiliation: Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
authors.forename: Saeid
authors.initials: S
authors.lastname: Shahrabi
authors.affiliation: Health research institute, Thalassemia & Hemoglobinopathy Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. najmaldinsaki@gmail.com.
authors.forename: Najmaldin
authors.initials: N
authors.lastname: Saki
mesh_terms: D017209:Apoptosis / Q000235:genetics; D005544:Forecasting; D015973:Gene Expression Regulation, Leukemic; D016147:Genes, Tumor Suppressor; D018816:Genes, cdc; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000502:physiology; D009857:Oncogenes; D011379:Prognosis
chemical_list: D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion
keywords: Acute myeloid leukemia; Oncogenes; Tumor suppressor genes