title: Sesamin Ameliorates High-Fat Diet-Induced Dyslipidemia and Kidney Injury by Reducing Oxidative Stress.
abstract: The study explored the protective effect of sesamin against lipid-induced renal injury and hyperlipidemia in a rat model. An animal model of hyperlipidemia was established in Sprague-Dawley rats. Fifty-five adult Sprague-Dawley rats were divided into five groups. The control group was fed a standard diet, while the other four groups were fed a high-fat diet for 5 weeks to induce hyperlipidemia. Three groups received oral sesamin in doses of 40, 80, or 160 mg/(kg·day). Seven weeks later, the blood lipids, renal function, antioxidant enzyme activities, and hyperoxide levels in kidney tissues were measured. The renal pathological changes and expression levels of collagen type IV (Col-IV) and α-smooth muscle actin (α-SMA) were analyzed. The administration of sesamin improved the serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, apolipoprotein-B, oxidized-low-density lipoprotein, and serum creatinine levels in hyperlipidemic rats, while it increased the high-density lipoprotein cholesterol and apolipoprotein-A levels. Sesamin reduced the excretion of 24-h urinary protein and urinary albumin and downregulated α-SMA and Col-IV expression. Moreover, sesamin ameliorated the superoxide dismutase activity and reduced malondialdehyde levels in kidney tissue. Sesamin could mediate lipid metabolism and ameliorate renal injury caused by lipid metabolism disorders in a rat model of hyperlipidemia.
authors.affiliation: Department of Nutrition and Food Safety, School of Public Health of Xi'an Jiao Tong University, Xi'an 710061, China. zhangrj@mail.xjtu.edu.cn.
authors.forename: Ruijuan
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Nutrition and Food Safety, School of Public Health of Xi'an Jiao Tong University, Xi'an 710061, China. yuyan@xjtu.edu.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Shaanxi Key laboratory of Degradable Biomedical Materials, Department of Food Science and Engineering, College of Chemical Engineering, Northwest University, Xi'an 710069, China. dengjianjun@nwu.edu.cn.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Deng
authors.affiliation: Department of Nutrition and Food Safety, School of Public Health of Xi'an Jiao Tong University, Xi'an 710061, China. zhangchao9277@163.com.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Nutrition and Food Safety, School of Public Health of Xi'an Jiao Tong University, Xi'an 710061, China. yyyyyy_214@163.com.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Nutrition and Food Safety, School of Public Health of Xi'an Jiao Tong University, Xi'an 710061, China. chengy@mail.xjtu.edu.cn.
authors.forename: Yue
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Nutrition and Food Safety, School of Public Health of Xi'an Jiao Tong University, Xi'an 710061, China. miniqiao@126.com.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Nutrition and Food Safety, School of Public Health of Xi'an Jiao Tong University, Xi'an 710061, China. hanbei@mail.xjtu.edu.cn.
authors.forename: Bei
authors.initials: B
authors.lastname: Han
authors.affiliation: Department of Nutrition and Food Safety, School of Public Health of Xi'an Jiao Tong University, Xi'an 710061, China. yanghx@xjtu.edu.cn.
authors.forename: Haixia
authors.initials: H
authors.lastname: Yang
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism; D000818:Animals; D024141:Collagen Type IV / Q000235:genetics / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects*; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D004149:Dioxoles / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D050171:Dyslipidemias / Q000209:etiology / Q000517:prevention & control*; D005786:Gene Expression Regulation / Q000187:drug effects; D007674:Kidney Diseases / Q000209:etiology / Q000517:prevention & control*; D017705:Lignans / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000199:Actins; D024141:Collagen Type IV; D004041:Dietary Fats; D004149:Dioxoles; D017705:Lignans; C498862:Acta2 protein, rat; C054125:sesamin
keywords: hyperlipidemia; lipid-induced kidney injury; oxidative stress; sesamin