title: Analysis of Olig2 and YKL-40 expression: a clinicopathological/immunohistochemical study for the distinction between subventricular zone II and III glioblastomas.
abstract: Glioblastomas (GBs) are the most common and lethal primary brain tumors in the adults. Glioblastomas originates either from astrocytes that have accumulated mutations and de-differentiated or from neural stem cells within the subventricular zone (SVZ) in close contact with the vasculature. Recently, several studies have hypothesized that gliomagenesis occurs in perivascular niches with highly invasive peripheral proliferating zones. The purpose of our study was to investigate the pathological and clinical significance of Olig2 and YKL40 immunoexpression in 152 GBs in relationship to the SVZ II and III. Olig2 expressions were successfully detected in 12 (15.58%) of 77 SVZ type II GBs and 16 (21.3%) of 75 SVZ type III GBs, respectively. YKL-40 expression was observed in 45 (58.4%) of 77 SVZ type II GBs and in 17 (22.6%) of 75 SVZ type III GBs, respectively. Stepwise multivariate Cox proportional hazards models were used, and the prognostic factors to significantly impact OS were: PFS < 54 weeks (HR: 5.86; CI: 3.02-11.33; p = 0.00); radiotherapy (HR: 0.34; CI: 0.18-0.60; p = 0.00); radio- and chemotherapy (HR: 0.05; CI: 0.03-0.10; p = 0.0), and YKL-40+ GBs (HR: 1.61; CI: 1.28-2.31; p = 0.01).
authors.affiliation: Kelvin Manuel Piña Batista, MD, MSc, MBA, PhD, Department of Neurosurgery, Hospital Universitario Central de Asturias, Av. de Las Segadas 22, 4a 33006 Oviedo, Spain, phone: +34 693 86 24 81, e-mail: pineappledr@gmail.com.
authors.forename: Kmp
authors.initials: K
authors.lastname: Batista
authors.forename: Bal
authors.initials: B
authors.lastname: Costa
authors.forename: Ica
authors.initials: I
authors.lastname: Pablo
authors.forename: I F
authors.initials: IF
authors.lastname: Vega
authors.forename: Jcg
authors.initials: J
authors.lastname: Morales
authors.forename: A V
authors.initials: AV
authors.lastname: Alvarez
authors.forename: A
authors.initials: A
authors.lastname: Meilán
authors.forename: A
authors.initials: A
authors.lastname: Astudillo
authors.forename: K Y
authors.initials: KY
authors.lastname: Alvarez
mesh_terms: D000328:Adult; D001253:Astrocytes / Q000378:metabolism; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D002454:Cell Differentiation / Q000235:genetics; D000071451:Chitinase-3-Like Protein 1 / Q000378:metabolism*; D005909:Glioblastoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D020547:Lateral Ventricles / Q000378:metabolism; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D000076104:Oligodendrocyte Transcription Factor 2; D014157:Transcription Factors / Q000378:metabolism; D055815:Young Adult
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D000071451:Chitinase-3-Like Protein 1; D009419:Nerve Tissue Proteins; D000076104:Oligodendrocyte Transcription Factor 2; D014157:Transcription Factors; C084533:CHI3L1 protein, human; C405708:OLIG2 protein, human