title: PRESS: PRotEin S-Sulfenylation server.
abstract: Transient S-sulfenylation of cysteine thiols mediated by reactive oxygen species plays a critical role in pathology, physiology and cell signaling. Therefore, discovery of new S-sulfenylated sites in proteins is of great importance towards understanding how protein function is regulated upon redox conditions.
  
  
  
  We developed PRESS (PRotEin S-Sulfenylation) web server, a server which can effectively predict the cysteine thiols of a protein that could undergo S-sulfenylation under redox conditions. We envisage that this server will boost and facilitate the discovery of new and currently unknown functions of proteins triggered upon redox conditions, signal regulation and transduction, thus uncovering the role of S-sulfenylation in human health and disease.
  
  
  
  The PRESS web server is freely available at http://press-sulfenylation.cse.uoi.gr/
  
  
  
  agtzakos@gmail.com or gtzortzi@cs.uoi.gr
  
  
  
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Department of Chemistry.
authors.forename: Marianna
authors.initials: M
authors.lastname: Sakka
authors.affiliation: Department of Computer Science and Engineering.
authors.forename: Grigorios
authors.initials: G
authors.lastname: Tzortzis
authors.affiliation: Laboratory of Biological Chemistry Faculty of Medicine, University of Ioannina, Ioannina, Greece.
authors.forename: Michalis D
authors.initials: MD
authors.lastname: Mantzaris
authors.affiliation: Department of Chemistry.
authors.forename: Nick
authors.initials: N
authors.lastname: Bekas
authors.affiliation: Department of Chemistry.
authors.forename: Tahsin F
authors.initials: TF
authors.lastname: Kellici
authors.affiliation: Department of Computer Science and Engineering.
authors.forename: Aristidis
authors.initials: A
authors.lastname: Likas
authors.affiliation: Laboratory of Biological Chemistry Faculty of Medicine, University of Ioannina, Ioannina, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Galaris
authors.affiliation: Department of Chemistry.
authors.forename: Ioannis P
authors.initials: IP
authors.lastname: Gerothanassis
authors.affiliation: Department of Chemistry.
authors.forename: Andreas G
authors.initials: AG
authors.lastname: Tzakos
mesh_terms: D003198:Computer Simulation; D003545:Cysteine; D006801:Humans; D010084:Oxidation-Reduction; D011499:Protein Processing, Post-Translational; D011506:Proteins; D020539:Sequence Analysis, Protein / Q000379:methods; D013438:Sulfhydryl Compounds; D013456:Sulfur Acids / Q000378:metabolism
chemical_list: D011506:Proteins; D013438:Sulfhydryl Compounds; D013456:Sulfur Acids; D003545:Cysteine