title: Analytic derivation of bacterial growth laws from a simple model of intracellular chemical dynamics.
abstract: Experiments have found that the growth rate and certain other macroscopic properties of bacterial cells in steady-state cultures depend upon the medium in a surprisingly simple manner; these dependencies are referred to as 'growth laws'. Here we construct a dynamical model of interacting intracellular populations to understand some of the growth laws. The model has only three population variables: an amino acid pool, a pool of enzymes that transport an external nutrient and produce the amino acids, and ribosomes that catalyze their own and the enzymes' production from the amino acids. We assume that the cell allocates its resources between the enzyme sector and the ribosomal sector to maximize its growth rate. We show that the empirical growth laws follow from this assumption and derive analytic expressions for the phenomenological parameters in terms of the more basic model parameters. Interestingly, the maximization of the growth rate of the cell as a whole implies that the cell allocates resources to the enzyme and ribosomal sectors in inverse proportion to their respective 'efficiencies'. The work introduces a mathematical scheme in which the cellular growth rate can be explicitly determined and shows that two large parameters, the number of amino acid residues per enzyme and per ribosome, are useful for making approximations.
authors.affiliation: Department of Physics and Astrophysics, University of Delhi, Delhi, 110007, India.
authors.forename: Parth Pratim
authors.initials: PP
authors.lastname: Pandey
authors.affiliation: Department of Physics and Astrophysics, University of Delhi, Delhi, 110007, India. jain@physics.du.ac.in.|The Simons Center for Systems Biology, Institute of Advanced Study, Princeton, NJ, 08540, USA. jain@physics.du.ac.in.|Santa Fe Institute, 1399, Hyde Park Road, Santa Fe, NM, 87501, USA. jain@physics.du.ac.in.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Jain
mesh_terms: D000465:Algorithms; D000596:Amino Acids / Q000737:chemistry; D001419:Bacteria / Q000254:growth & development*; D018407:Bacterial Physiological Phenomena; D002384:Catalysis; D004798:Enzymes / Q000502:physiology; D008962:Models, Theoretical; D009154:Mutation; D017711:Nonlinear Dynamics; D012270:Ribosomes / Q000502:physiology*
chemical_list: D000596:Amino Acids; D004798:Enzymes
keywords: Bacterial growth laws; Cellular economy; Chemical dynamics; Growth rate optimization; Mathematical modeling