title: Sevoflurane-induced pica in female rats.
abstract: We examined the effects of volatile anesthetics on pica, which can be used to assess nausea and vomiting in rats. We found that inhalation anesthesia with sevoflurane significantly induced pica in female but not male rats. Among the female rats, young rats (8 weeks old) were more susceptible to its induction than adult rats (20 weeks old) with ovariectomy or sham-surgery. Anti-emetic drugs that are used to prevent postoperative nausea and vomiting (PONV) inhibited the pica. These results suggest that sevoflurane-induced pica in young female rats has the potential to be an animal model of PONV in humans.
authors.affiliation: Department of Medical Science and Technology, Division of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: kouichi@sahs.med.osaka-u.ac.jp.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Department of Anesthesiology, Kaizuka City Hospital, 3-10-20 Hori, Kaizuka, Osaka 597-0015, Japan.
authors.forename: Emiri
authors.initials: E
authors.lastname: Yamamoto
authors.affiliation: Department of Medical Science and Technology, Division of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Sugimoto
authors.affiliation: Department of Medical Science and Technology, Division of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Sagakami
authors.affiliation: Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamatodani
mesh_terms: D018685:Anesthetics, Inhalation; D000818:Animals; D000932:Antiemetics / Q000494:pharmacology; D004435:Eating; D005260:Female; D007616:Kaolin; D008297:Male; D008738:Methyl Ethers; D010842:Pica / Q000139:chemically induced* / Q000188:drug therapy; D020250:Postoperative Nausea and Vomiting; D017208:Rats, Wistar; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D000932:Antiemetics; D008738:Methyl Ethers; D007616:Kaolin; D000077149:Sevoflurane
keywords: Anti-emetic drugs; Pica; Postoperative nausea and vomiting