title: Exploring Big Data in Hematological Malignancies: Challenges and Opportunities.
abstract: Secondary analysis of large datasets has become a useful alternative to address research questions outside the reach of clinical trials. It is increasingly utilized in hematology and oncology. In this review, we provided an overview of some examples of commonly used large datasets in the USA and described common research themes that can be pursued using such a methodology. We selected a sample of 14 articles on adult hematologic malignancies published in 2015 and highlighted their contributions as well as limitations.
authors.affiliation: Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
authors.forename: Gustavo F
authors.initials: GF
authors.lastname: Westin
authors.affiliation: Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
authors.forename: Ajoy L
authors.initials: AL
authors.lastname: Dias
authors.affiliation: Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. go.ronald@mayo.edu.
authors.forename: Ronald S
authors.initials: RS
authors.lastname: Go
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016208:Databases, Factual; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000191:economics / Q000473:pathology* / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006689:Hodgkin Disease / Q000175:diagnosis / Q000191:economics / Q000473:pathology / Q000628:therapy; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000191:economics / Q000473:pathology / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000191:economics / Q000473:pathology / Q000628:therapy; D009101:Multiple Myeloma / Q000175:diagnosis / Q000191:economics / Q000473:pathology / Q000628:therapy
keywords: Acute myeloid leukemia; Amyloidosis; Diffuse large B cell lymphoma; Hematopoietic stem cell transplantation; Hodgkin lymphoma; Multiple myeloma