title: Two Uncommon Paraneoplastic Neurological Syndromes in a Child With Hodgkin Lymphoma.
abstract: Paraneoplastic neurological syndromes (PNS) are rare, remote effects of cancer that are usually caused by an altered immune response to the tumor and not due to the tumor mass, metastasis, infection, ischemia, or metabolic derangements. PNSs can affect any area of the central, the peripheral, and the autonomic nervous systems. These are rare in lymphomas compared with solid tumors attributed to their presentation even in late stages and the absence of onconeural antibodies. We present a child with stage IIB Hodgkin lymphoma who presented with dual PNS, achalasia cardia, and Holmes Adie pupil occurring synchronously with the cancer.
authors.affiliation: Departments of *Pediatric Hemato-Oncology †Pediatric Ophthalmology ‡Pediatric Gastroenterology, Kanchi Kamakoti CHILDS Trust Hospital, The CHILDS Trust Medical Research Foundation, Chennai, Tamil Nadu, India.
authors.forename: Arathi
authors.initials: A
authors.lastname: Srinivasan
authors.forename: Gayathri
authors.initials: G
authors.lastname: Satish
authors.forename: Julius X
authors.initials: JX
authors.lastname: Scott
authors.forename: Ramprakash
authors.initials: R
authors.lastname: Madhavan
authors.forename: Malathi
authors.initials: M
authors.lastname: Sathiyasekaran
mesh_terms: D000270:Adie Syndrome / Q000209:etiology*; D002648:Child; D004931:Esophageal Achalasia / Q000209:etiology*; D019788:Fluorodeoxyglucose F18; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008297:Male; D020361:Paraneoplastic Syndromes, Nervous System / Q000209:etiology*; D049268:Positron-Emission Tomography
chemical_list: D019788:Fluorodeoxyglucose F18