title: T cell adhesion triggers an early signaling pole distal to the immune synapse.
abstract: The immunological synapse forms at the interface between a T cell and an antigen-presenting cell after foreign antigen recognition. The immunological synapse is considered to be the site where the signaling cascade leading to T lymphocyte activation is triggered. Here, we show that another signaling region can be detected before formation of the synapse at the opposite pole of the T cell. This structure appears during the first minute after the contact forms, is transient and contains all the classic components that have been previously described at the immunological synapse. Its formation is independent of antigen recognition but is driven by adhesion itself. It constitutes a reservoir of signaling molecules that are potentially ready to be sent to the immunological synapse through a microtubule-dependent pathway. The antisynapse can thus be considered as a pre-synapse that is triggered independently of antigen recognition.
authors.affiliation: INSERM, U1016, Institut Cochin, Infection, Immunity and Inflammation Department, 22 rue Méćhain, Paris 75014, France CNRS, UMR8104, Paris 75014, France Université Paris Descartes, Sorbonne Paris Cité, Paris 75014, France.
authors.forename: Chloé
authors.initials: C
authors.lastname: Guedj
authors.affiliation: INSERM, U1016, Institut Cochin, Infection, Immunity and Inflammation Department, 22 rue Méćhain, Paris 75014, France CNRS, UMR8104, Paris 75014, France Université Paris Descartes, Sorbonne Paris Cité, Paris 75014, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Abraham
authors.affiliation: INSERM, U1016, Institut Cochin, Infection, Immunity and Inflammation Department, 22 rue Méćhain, Paris 75014, France CNRS, UMR8104, Paris 75014, France Université Paris Descartes, Sorbonne Paris Cité, Paris 75014, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Jullié
authors.affiliation: INSERM, U1016, Institut Cochin, Infection, Immunity and Inflammation Department, 22 rue Méćhain, Paris 75014, France CNRS, UMR8104, Paris 75014, France Université Paris Descartes, Sorbonne Paris Cité, Paris 75014, France clotilde.randriamampita@inserm.fr.
authors.forename: Clotilde
authors.identifier: 0000-0001-8594-7831
authors.initials: C
authors.lastname: Randriamampita
mesh_terms: D000938:Antigen-Presenting Cells / Q000276:immunology; D002448:Cell Adhesion / Q000276:immunology*; D002450:Cell Communication / Q000235:genetics / Q000276:immunology; D006801:Humans; D054992:Immunological Synapses / Q000235:genetics*; D019169:Jurkat Cells / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D011948:Receptors, Antigen, T-Cell
keywords: Adhesion; Immunological synapse; T lymphocytes