title: Linear antimicrobial peptides with activity against herpes simplex virus 1 and Aichi virus.
abstract: Viruses are the major cause of disease and mortality worldwide. Nowadays there are treatments based on antivirals or prophylaxis with vaccines. However, the rising number of reports of viral resistance to current antivirals and the emergence of new types of virus has concerned the scientific community. In this scenario, the search for alternative treatments has led scientists to the discovery of antimicrobial peptides (AMPs) derived from many different sources. Since some of them have shown antiviral activities, here we challenged 10 synthetic peptides from different animal and plant sources against, herpes simplex virus 1 (HSV-1), and Aichi virus. Among them, the highlight was Pa-MAP from the polar fish Pleuronectes americanus, which caused around 90% of inhibition of the HSV with a selectivity index of 5 and a virucidal mechanism of action. Moreover, LL-37 from human neutrophils showed 96% of inhibition against the Aichi virus, showing a selectivity index of 3.4. The other evaluated peptides did not show significant antiviral activity. In conclusion, the present study demonstrated that Pa-MAP seems to be a reliable candidate for a possible alternative drug to treat HSV-1 infections. © 2016 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 108: 1-6, 2017.
authors.affiliation: Centro De Análises Proteômicas E Bioquímicas: Programa De Pós-Graduação Em Ciências Genômicas E Biotecnologia, Universidade Católica De Brasília, Distrito Federal, Brazil.
authors.forename: Liana Costa Pereira
authors.initials: LC
authors.lastname: Vilas Boas
authors.affiliation: Centro De Análises Proteômicas E Bioquímicas: Programa De Pós-Graduação Em Ciências Genômicas E Biotecnologia, Universidade Católica De Brasília, Distrito Federal, Brazil.
authors.forename: Lídia Maria Pinto
authors.initials: LM
authors.lastname: de Lima
authors.affiliation: Centro De Análises Proteômicas E Bioquímicas: Programa De Pós-Graduação Em Ciências Genômicas E Biotecnologia, Universidade Católica De Brasília, Distrito Federal, Brazil.|S-Inova Biotech, Pós-Graduação Em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil.
authors.forename: Ludovico
authors.initials: L
authors.lastname: Migliolo
authors.affiliation: Centro De Análises Proteômicas E Bioquímicas: Programa De Pós-Graduação Em Ciências Genômicas E Biotecnologia, Universidade Católica De Brasília, Distrito Federal, Brazil.
authors.forename: Gabriele Dos Santos
authors.initials: GD
authors.lastname: Mendes
authors.affiliation: Centro De Análises Proteômicas E Bioquímicas: Programa De Pós-Graduação Em Ciências Genômicas E Biotecnologia, Universidade Católica De Brasília, Distrito Federal, Brazil.
authors.forename: Maianne Gonçalves
authors.initials: MG
authors.lastname: de Jesus
authors.affiliation: Centro De Análises Proteômicas E Bioquímicas: Programa De Pós-Graduação Em Ciências Genômicas E Biotecnologia, Universidade Católica De Brasília, Distrito Federal, Brazil.|S-Inova Biotech, Pós-Graduação Em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil.
authors.forename: Octávio Luiz
authors.initials: OL
authors.lastname: Franco
authors.affiliation: Centro De Análises Proteômicas E Bioquímicas: Programa De Pós-Graduação Em Ciências Genômicas E Biotecnologia, Universidade Católica De Brasília, Distrito Federal, Brazil.
authors.forename: Paula Andréia
authors.initials: PA
authors.lastname: Silva
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D052699:Kobuvirus / Q000187:drug effects* / Q000254:growth & development; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D014709:Vero Cells
chemical_list: D000890:Anti-Infective Agents; D000998:Antiviral Agents; D010455:Peptides
keywords: Aichi virus; HSV-1; antiviral peptides; virucidal