title: Does thalassemia influence ovarian response? An analysis of 127 cycles involving pre-implantation genetic diagnosis of thalassemia in southern China.
abstract: To evaluate the impact of thalassemia carrier status on the response to controlled ovarian stimulation (COS) and outcome of intracytoplasmic sperm injection (ICSI). Seventy couples that both carried a mutation attributed to thalassemia (PGD group) and 57 couples in which only the father was a thalassemia carrier (CON group) were enrolled. All female subjects received long protocol GnRH agonist stimulation and received equivalent doses of recombinant follicle-stimulating hormone and the number of retrieved oocytes and utilisable embryos did not differ significantly. The endometrial thickness at human chorionic gonadotropin (hCG) administration day and the number of transferable embryos was lower in the PGD groups. However, pregnancy outcomes, including the clinical pregnancy rate and ongoing pregnancy rate, did not differ significantly between the two groups per cycle. Ovarian response to COS is not impaired by maternal thalassemia carrier status and embryo biopsy did not impair preimplantation embryo development or pregnancy outcomes.
authors.affiliation: a Reproductive Research Center , The First Affiliated Hospital of Sun Yat-Sen University , Guangzhou , China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: a Reproductive Research Center , The First Affiliated Hospital of Sun Yat-Sen University , Guangzhou , China.
authors.forename: Xi
authors.initials: X
authors.lastname: Yuan
authors.affiliation: a Reproductive Research Center , The First Affiliated Hospital of Sun Yat-Sen University , Guangzhou , China.
authors.forename: Canquan
authors.initials: C
authors.lastname: Zhou
mesh_terms: D000328:Adult; D002681:China; D006063:Chorionic Gonadotropin; D010064:Embryo Implantation / Q000235:genetics*; D004624:Embryo Transfer / Q000379:methods; D005191:Family Characteristics; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage; D006579:Heterozygote; D006728:Hormones / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008597:Menstrual Cycle / Q000235:genetics*; D008875:Middle Aged; D054315:Oocyte Retrieval / Q000379:methods; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods; D013789:Thalassemia / Q000235:genetics*; D055815:Young Adult
chemical_list: D006063:Chorionic Gonadotropin; D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone
keywords: Controlled ovarian stimulation; PGD; couple carrier; ovarian response; thalassemia