title: Biomimetic solution against dewetting in a highly hydrophobic nanopore.
abstract: A water molecule is the foundation of life and is the primary compound in every living system. While many of its properties are understood in a bulk solvent, its behavior in a small hydrophobic nanopore still raises fundamental questions. For instance, a wetting/dewetting transition in a hydrophobic solid-state or a polymer nanopore occurs stochastically and can only be prevented by external physical stimuli. Controlling these transitions would be a primary requirement to improve many applications. Some biological channels, such as gramicidin A (gA) proteins, show a high rate of water and ion diffusion in their central subnanochannel while their external surface is highly hydrophobic. The diameter of this channel is significantly smaller than the inner size of the lowest artificial nanopore in which water drying occurs (i.e. 1.4 nm). In this paper, we propose an innovative idea to generate nanopore wetting as a result of which the application of an external field is no longer required. In a nanopore, the drying or wetting of the inner walls occurs randomly (in experiments and in simulations). However, we have shown how the confinement of gA, in a dried hydrophobic nanopore, rapidly generates a stable wetting of the latter. We believe that this simple idea, based on biomimetism, could represent a real breakthrough that could help to improve and develop new nanoscale applications.
authors.affiliation: Laboratoire de Nanomédecine, Imagerie et Thérapeutique, EA 4662, Université Bourgogne Franche-Comté, Centre Hospitalier Universitaire de Besançon, 16 route de Gray, 25030 Besançon cedex, France. fabien.picaud@univ-fcomte.fr.
authors.forename: Fabien
authors.initials: F
authors.lastname: Picaud
authors.forename: Guillaume
authors.initials: G
authors.lastname: Paris
authors.forename: Tijani
authors.initials: T
authors.lastname: Gharbi
authors.forename: Sébastien
authors.initials: S
authors.lastname: Balme
authors.forename: Mathilde
authors.initials: M
authors.lastname: Lepoitevin
authors.forename: Vidhyadevi
authors.initials: V
authors.lastname: Tangaraj
authors.forename: Mikhael
authors.initials: M
authors.lastname: Bechelany
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Janot
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Balanzat
authors.forename: François
authors.initials: F
authors.lastname: Henn
mesh_terms: D032701:Biomimetics; D004058:Diffusion; D057927:Hydrophobic and Hydrophilic Interactions; D058608:Nanopores; D017155:Wettability