title: Diagnostic Accuracy of the Frontotemporal Dementia Consensus Criteria in the Late-Onset Frontal Lobe Syndrome.
abstract: We aimed to prospectively assess the diagnostic accuracy of the revised criteria for behavioural variant frontotemporal dementia (bvFTD) among subjects presenting with a frontal lobe syndrome in middle-late adulthood.
  
  
  
  Patients were included based on a predominant behavioural clinical presentation, a Frontal Behavioural Inventory (FBI) score of ≥11 and/or a Stereotypy Rating Inventory (SRI) score of ≥10. At baseline, the fulfilment of the international consensus criteria for behavioural variant FTD (FTDC) was systematically recorded. The 2-year follow-up consensus diagnosis was used as the gold standard to calculate sensitivity and specificity of the FTDC criteria for possible and probable bvFTD.
  
  
  
  Two-year follow-up data were available for 116 patients (85%). Two-year follow-up consensus diagnoses consisted of probable/definite bvFTD (n = 27), other dementia (n = 30), psychiatric disorders (n = 46) and other neurological disorders (n = 13). Sensitivity for possible bvFTD was 85% (95% CI 70-95%) at a specificity of 27% (95% CI 19-37%). Sensitivity for probable bvFTD was 85% (95% CI 69-95%), whereas their specificity was 82% (95% CI 73-89%).
  
  
  
  We found a good diagnostic accuracy for FTDC probable bvFTD. However, the specificity for FTDC possible bvFTD was low. Our results reflect the symptomatic overlap between bvFTD, other neurological conditions and psychiatric disorders, and the relevance of adding neuroimaging to the diagnostic process.
authors.affiliation: Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands.
authors.forename: Everard G B
authors.initials: EG
authors.lastname: Vijverberg
authors.forename: Annemiek
authors.initials: A
authors.lastname: Dols
authors.forename: Welmoed A
authors.initials: WA
authors.lastname: Krudop
authors.forename: Anne
authors.initials: A
authors.lastname: Peters
authors.forename: Cora J
authors.initials: CJ
authors.lastname: Kerssens
authors.forename: Bart N M
authors.initials: BN
authors.lastname: van Berckel
authors.forename: Mike P
authors.initials: MP
authors.lastname: Wattjes
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
authors.forename: Flora
authors.initials: F
authors.lastname: Gossink
authors.forename: Niels D
authors.initials: ND
authors.lastname: Prins
authors.forename: Max L
authors.initials: ML
authors.lastname: Stek
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.forename: Yolande A L
authors.initials: YA
authors.lastname: Pijnenburg
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005500:Follow-Up Studies; D057180:Frontotemporal Dementia / Q000175:diagnosis; D057174:Frontotemporal Lobar Degeneration / Q000175:diagnosis; D009483:Neuropsychological Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D003245:Consensus Statements as Topic