title: Eremophilane Sesquiterpenes from the Genus Ligularia.
abstract: Ligularia speices are widely used in Asian folk medicines for the treatment of various human diseases. Eremophilane-type sesquiterpenes are abundant and typical secondary metabolites found in this genus. Over 500 eremophilanes reported from members of Ligularia are reviewed in this article together with bioactivity data in an effort to highlight the development in this field.
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, P. R. China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, P. R. China. zxliao@seu.edu.cn.
authors.forename: Zhixin
authors.initials: Z
authors.lastname: Liao
authors.affiliation: Institute of Agro-Food Science and Technology, Shangdong Academy of Agricultural Sciences, 202 Gongyue North Road, Jinan, 250110, P. R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, P. R. China.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Jia
authors.affiliation: Institute of Agro-Food Science and Technology, Shangdong Academy of Agricultural Sciences, 202 Gongyue North Road, Jinan, 250110, P. R. China.
authors.forename: Jinyue
authors.initials: J
authors.lastname: Sun
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D002460:Cell Line; D056945:Hep G2 Cells; D006515:Hepatitis B virus / Q000187:drug effects; D006801:Humans; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D008070:Lipopolysaccharides; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C018286:eremophilane compounds; D009569:Nitric Oxide
keywords: Bioactivities; Chemical diversity; Compositae; Cytotoxicities; Eremophilane sesquiterpenes; Ligularia