title: Mechanism of fat taste perception: Association with diet and obesity.
abstract: Energy homeostasis plays a significant role in food consumption and body weight regulation with fat intake being an area of particular interest due to its palatability and high energy density. Increasing evidence from humans and animal studies indicate the existence of a taste modality responsive to fat via its breakdown product fatty acids. These studies implicate multiple candidate receptors and ion channels for fatty acid taste detection, indicating a complex peripheral physiology that is currently not well understood. Additionally, a limited number of studies suggest a reduced ability to detect fatty acids is associated with obesity and a diet high in fat reduces an individual's ability to detect fatty acids. To support this, genetic variants within candidate fatty acid receptors are also associated with obesity reduced ability to detect fatty acids. Understanding oral peripheral fatty acid transduction mechanisms and the association with fat consumption may provide the basis of novel approaches to control development of obesity.
authors.affiliation: School of Exercise and Nutrition Sciences, Deakin University, Burwood, VIC, Australia; CSIRO, Food & Nutrition, North Ryde, NSW, Australia.
authors.forename: Dongli
authors.initials: D
authors.lastname: Liu
authors.affiliation: CSIRO, Food & Nutrition, North Ryde, NSW, Australia.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Archer
authors.affiliation: CSIRO, Food & Nutrition, North Ryde, NSW, Australia.
authors.forename: Konsta
authors.initials: K
authors.lastname: Duesing
authors.affiliation: CSIRO, Food & Nutrition, North Ryde, NSW, Australia.
authors.forename: Garry
authors.initials: G
authors.lastname: Hannan
authors.affiliation: School of Exercise and Nutrition Sciences, Deakin University, Burwood, VIC, Australia. Electronic address: russell.keast@deakin.edu.au.
authors.forename: Russell
authors.initials: R
authors.lastname: Keast
mesh_terms: D000818:Animals; D018955:CD36 Antigens / Q000378:metabolism; D002450:Cell Communication; D051668:Delayed Rectifier Potassium Channels / Q000378:metabolism; D004032:Diet; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D009765:Obesity / Q000378:metabolism* / Q000473:pathology; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D055697:Taste Perception / Q000502:physiology*
chemical_list: D018955:CD36 Antigens; D051668:Delayed Rectifier Potassium Channels; D005227:Fatty Acids; D043562:Receptors, G-Protein-Coupled
keywords: Fat; Obesity; Taste perception