title: Models for Self-Assembly of Nanoscale Systems with Biomedical Applications.
abstract: Understanding the physicochemical basis and the different models of nanosystems is nowadays fundamental in a great number of scientific areas and industrial processes.
  
  
  
  Here, we focus on nanosystems created by self-assembly, molecular or inorganic. The organization of single units at these scales is a challenging matter in light of the inherently small dimensions involved, the sensitivity of the system to small perturbations, and the problem of scaling up such a process for widespread use and implementation.
  
  
  
  This review examines the different self-assembly routes used to create nanostructures in both the equilibrium and non-equilibrium/dynamic systems and discusses their limits and applications. The connection to biomedicine and pharmaceutical design has been emphasized.
authors.forename: Paula V
authors.initials: PV
authors.lastname: Messina
authors.forename: Ramon
authors.initials: R
authors.lastname: Rial
authors.affiliation: Soft Matter and Molecular Biophysics Group, Department of Applied Physics, University of Santiago de Compostela, Santiago de Compostela, 15782, Spain. juanm.ruso@usc.es.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Ruso
mesh_terms: D035843:Biomedical Research; D006801:Humans; D008956:Models, Chemical; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology; D013816:Thermodynamics