title: Clinicopathological Characteristics of Young Patients With Pancreatic Cancer: An Analysis of Data From Pancreatic Cancer Registry of Japan Pancreas Society.
abstract: The aim of this study was to determine the characteristics of patients with pancreatic ductal adenocarcinoma younger than 40 years.
  
  
  
  Data from the Japan Pancreas Society's nationwide Pancreatic Cancer Registry were analyzed retrospectively. Clinicopathological characteristics were compared in patients who were grouped according to age, namely, younger than 40 years versus 40 years and older.
  
  
  
  Of the 36 145 patients in the database, the younger group included 526 (1.5%) patients. A family history of pancreatic cancer was not more frequent in the younger group. The frequency of Union Internationale Contre le Cancer T4 and M1 were both significantly higher in younger patients, resulting in a higher percentage of patients with Union Internationale Contre le Cancer stage IV. Pancreatectomy was performed less frequently in the younger group, and R0 resection was also less frequent. The overall survival rate was significantly better in the older group, whereas in surgically resected patients, the overall survival and recurrence-free survival rates were not different between the 2 groups.
  
  
  
  Younger patients with pancreatic adenocarcinoma were more often diagnosed at advanced stages, and the overall survival rate was worse than that in older patients. Family genetic background and the prognoses of patients who underwent surgery were similar between the 2 groups.
authors.affiliation: From the *Japan Pancreas Society, Sendai; †Department of Surgery, Graduate School of Medicine, Osaka University, Osaka; ‡Second Department of Surgery, Wakayama Medical University, Wakayama; §Department of Surgery and ∥Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai; ¶Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka; #Department of Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki; **Department of Surgery, Kansai Medical University, Osaka; ††Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya; ‡‡Department of Surgery, Shiga University of Medical Science, Otsu; §§Department of Gastroenterology, IMS Sapporo Digestive Center General Hospital, Sapporo; ∥∥Department of Endoscopy, Nagoya University Hospital; and ¶¶Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya; ##Kyushu University Hospital Cancer Center, Fukuoka; ***Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo; †††Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto; and ‡‡‡Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Eguchi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yamaue
authors.forename: Michiaki
authors.initials: M
authors.lastname: Unno
authors.forename: Masamichi
authors.initials: M
authors.lastname: Mizuma
authors.forename: Shin
authors.initials: S
authors.lastname: Hamada
authors.forename: Hisato
authors.initials: H
authors.lastname: Igarashi
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Kuroki
authors.forename: Sohei
authors.initials: S
authors.lastname: Satoi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Masaji
authors.initials: M
authors.lastname: Tani
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanno
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hirooka
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fujii
authors.forename: Atsushi
authors.initials: A
authors.lastname: Masamune
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Mizumoto
authors.forename: Takao
authors.initials: T
authors.lastname: Itoi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Egawa
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Kodama
authors.forename: Masao
authors.initials: M
authors.lastname: Tanaka
authors.forename: Tooru
authors.initials: T
authors.lastname: Shimosegawa
mesh_terms: D000328:Adult; D021441:Carcinoma, Pancreatic Ductal; D006801:Humans; D007564:Japan; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms; D012042:Registries