title: Biodegradable PEG-Based Amphiphilic Block Copolymers for Tissue Engineering Applications.
abstract: Biodegradable tissue engineering scaffolds have great potential for delivering cells/therapeutics and supporting tissue formation. Polyesters, the most extensively investigated biodegradable synthetic polymers, are not ideally suited for diverse tissue engineering applications due to limitations associated with their hydrophobicity. This review discusses the design and applications of amphiphilic block copolymer scaffolds integrating hydrophilic poly(ethylene glycol) (PEG) blocks with hydrophobic polyesters. Specifically, we highlight how the addition of PEG results in striking changes to the physical properties (swelling, degradation, mechanical, handling) and biological performance (protein & cell adhesion) of the degradable synthetic scaffoldsin vitro. We then perform a critical review of how thesein vitrocharacteristics translate to the performance of biodegradable amphiphilic block copolymer-based scaffolds in the repair of a variety of tissuesin vivoincluding bone, cartilage, skin, and spinal cord/nerve. We conclude the review with recommendations for future optimizations in amphiphilic block copolymer design and the need for better-controlledin vivostudies to reveal the true benefits of the amphiphilic synthetic tissue scaffolds.
authors.affiliation: Department of Orthopedics and Physical Rehabilitation. University of Massachusetts Medical School. 55 Lake Ave North, Worcester, MA 01655, USA.
authors.forename: Artem B
authors.initials: AB
authors.lastname: Kutikov
authors.affiliation: Department of Orthopedics and Physical Rehabilitation. University of Massachusetts Medical School. 55 Lake Ave North, Worcester, MA 01655, USA; Department of Cell and Developmental Biology. University of Massachusetts Medical School. 55 Lake Ave North, Worcester, MA 01655, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Song
keywords: amphiphilic polymers; biodegradable; block copolymers; poly(ethylene glycol) (PEG); tissue engineering scaffolds