title: Long non-coding RNAs in normal and malignant hematopoiesis.
abstract: Long non-coding RNAs (lncRNAs) are defined as ncRNAs of more than 200 nt in length. They are involved in a large spectrum of biological processes, such as maintenance of genome integrity, genomic imprinting, cell differentiation, and development by means of mechanisms that remain to be fully elucidated. Besides their role in normal cellular physiology, accumulating evidence has linked lncRNA expression and functions to cancer development and progression. In this review, we summarize and discuss what is known about their expression and roles in hematopoiesis with a particular focus on their cell-type speciï¬city, functional interactions, and involvement in the pathobiology of hematological malignancies.
authors.affiliation: Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Hematology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Nobili
authors.affiliation: Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Hematology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Lionetti
authors.affiliation: Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Hematology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Neri
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics; D002454:Cell Differentiation; D019337:Hematologic Neoplasms / Q000235:genetics*; D006410:Hematopoiesis / Q000235:genetics*; D006801:Humans; D051379:Mice; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding
keywords: hematological malignancies; hematopoiesis; long non-coding RNAs; transcriptional regulation; translation regulation