title: The remarkable S. Harvey Mudd - A reminiscence.
abstract: Harvey Mudd was the father of methionine metabolic disorders. Beginning with his identification of the enzyme defect in homocystinuria, he co-discovered cobalamin C disorder as the first known human disorder of vitamin B12 metabolism, thereby extending our concept of homocystinuria as a key feature of related disorders rather than a single disease, and identified new disorders that produce hypermethioninemia. He had no equal in our understanding of how critical methionine metabolism is to human homeostasis.
authors.affiliation: Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States. Electronic address: harvey.levy@childrens.harvard.edu.
authors.forename: Harvey L
authors.initials: HL
authors.lastname: Levy
mesh_terms: D000592:Amino Acid Metabolism, Inborn Errors / Q000175:diagnosis*; D035843:Biomedical Research; D050938:Glycine N-Methyltransferase / Q000172:deficiency*; D049673:History, 20th Century; D049674:History, 21st Century; D006712:Homocystinuria / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008715:Methionine / Q000378:metabolism*; D014806:Vitamin B 12 Deficiency / Q000151:congenital* / Q000175:diagnosis
chemical_list: D008715:Methionine; D050938:Glycine N-Methyltransferase
keywords: Cobalamin C disorder; Cystathionine β-synthase; Harvey Mudd; Homocystinuria; Methionine metabolism