title: T-cell immune adaptor SKAP1 regulates the induction of collagen-induced arthritis in mice.
abstract: SKAP1 is an immune cell adaptor that couples the T-cell receptor with the 'inside-out' signalling pathway for LFA-1 mediated adhesion in T-cells. A connection of SKAP1 to the regulation of an autoimmune disorder has not previously been reported. In this study, we show that Skap1-deficient (skap1-/-) mice are highly resistant to the induction of collagen-induced arthritis (CIA), both in terms of incidence or severity. Skap1-/- T-cells were characterised by a selective reduction in the presence IL-17+ (Th17) in response to CII peptide and a marked reduction of joint infiltrating T-cells in Skap1-/- mice. SKAP1 therefore represents a novel connection to Th17 producing T-cells and is new potential target in the therapeutic intervention in autoimmune and inflammatory diseases.
authors.affiliation: Cell Signalling Section, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1Q, UK.
authors.forename: Xin
authors.initials: X
authors.lastname: Smith
authors.affiliation: Cell Signalling Section, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1Q, UK.
authors.forename: Alison
authors.initials: A
authors.lastname: Taylor
authors.affiliation: Cell Signalling Section, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1Q, UK. Electronic address: cer51@cam.ac.uk.
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Rudd
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology*; D002465:Cell Movement; D024043:Collagen Type II / Q000276:immunology; D004198:Disease Susceptibility; D020381:Interleukin-17 / Q000378:metabolism; D007596:Joints / Q000276:immunology*; D008213:Lymphocyte Activation; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism; D051379:Mice; D008811:Mice, Inbred DBA; D018345:Mice, Knockout; D010750:Phosphoproteins / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D058504:Th17 Cells / Q000276:immunology*; D008565:Membrane Proteins
chemical_list: D024043:Collagen Type II; D020381:Interleukin-17; D016169:Lymphocyte Function-Associated Antigen-1; D010750:Phosphoproteins; C514255:SKAP1 protein, mouse; D008565:Membrane Proteins
keywords: Adaptor; Murine autoimmune arthritis; SKAP-55; SKAP1; T-cells