title: A smart upconversion-based light-triggered polymer for synergetic chemo-photodynamic therapy and dual-modal MR/UCL imaging.
abstract: We have developed a novel nanocomposite to achieve effective therapy and live surveillance of tumor tissue. In this study, fullerene (C60) with iron oxide (Fe3O4) nanoparticles and upconversion nanophosphors (UCNPs) was loaded into N-succinyl-N'-4-(2-nitrobenzyloxy)-succinyl-chitosan micelles (SNSC) with good biocompatibility. In addition, hydrophobic anticancer drug docetaxel (DTX) was also loaded into the nanocomposites. The experiments conducted in vitro and in vivo demonstrated that C60/Fe3O4-UCNPs@DTX@SNSC can act synergistically to kill tumor cells by releasing chemotherapy drugs at specific target site as well as generating reactive oxygen using 980nm. In addition, it can also be used for non-invasive deep magnetic resonance and upconversion fluorescence dual-mode imaging. The results indicated that this system provided an efficient method to surmount the drawback of UV or visible light-responsive polymeric systems for controlled drug release and generated reactive oxygen in deep tissues and ultimately realized the integration of dual-modal imaging and treatment.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Du
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Han
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Singapore Institute of Technology, Singapore.
authors.forename: Kok Hwa
authors.initials: KH
authors.lastname: Lim
authors.affiliation: Singapore Institute of Technology, Singapore.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Xi
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
authors.forename: Xiangjie
authors.initials: X
authors.lastname: Su
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, China. Electronic address: yhchpaper@sina.com.
authors.forename: Hanchun
authors.initials: H
authors.lastname: Yao
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, China. Electronic address: zhj_paper@sina.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
mesh_terms: D045744:Cell Line, Tumor; D037741:Fullerenes; D006801:Humans; D053768:Metal Nanoparticles; D008823:Micelles; D010778:Photochemotherapy; D011108:Polymers
chemical_list: D037741:Fullerenes; D008823:Micelles; D011108:Polymers
keywords: Dual-mode imaging; Light-responsive systems; Smart; Treatment