title: Implications of MDSCs-targeting in lung cancer chemo-immunotherapeutics.
abstract: Despite advances in chemotherapy and immunotherapy, advanced lung cancer remains an incurable disease. Novel trends in anticancer therapeutics focus on harnessing the therapeutically-targeted tumor-related immune suppression. In this respect, myeloid-derived suppressor cells (MDSCs) have captured considerable attention in the last few years, as they are vividly implicated in tumor immune escape mechanisms. In this review, we specifically discuss the multifaceted roles of MDSCs in lung tumor microenvironment, encompassing lung tumor growth and progression via suppression of anti-tumor immunity, association with worse prognosis, and hampering the efficacy of lung cancer chemotherapy and immunotherapy. In addition, we also discuss that therapeutic manipulation of MDSCs-targeting, either alone or in combination with chemo- and/or immune-therapeutic regimens, may not only have tumor growth inhibition, anti-angiogenesis and anti-metastasis effects, but may also have the potential to enhance the efficacy of lung cancer chemotherapy and immunotherapy.
authors.affiliation: State Key Laboratory of Respiratory Disease, Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Heath, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, PR China; University of Chinese, Academy of Sciences, No. 19 Yuquan Road, Beijing 100049, PR China.
authors.forename: Dickson
authors.initials: D
authors.lastname: Adah
authors.affiliation: State Key Laboratory of Respiratory Disease, Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Heath, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, PR China; University of Chinese, Academy of Sciences, No. 19 Yuquan Road, Beijing 100049, PR China.
authors.forename: Muzammal
authors.initials: M
authors.lastname: Hussain
authors.affiliation: State Key Laboratory of Respiratory Disease, Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Heath, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, PR China.
authors.forename: Limei
authors.initials: L
authors.lastname: Qin
authors.affiliation: State Key Laboratory of Respiratory Disease, Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Heath, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Qin
authors.affiliation: State Key Laboratory of Respiratory Disease, Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Heath, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, PR China.
authors.forename: Jiancun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Respiratory Disease, Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Heath, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, PR China. Electronic address: chen_xiaoping@gibh.ac.cn.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D000072737:Myeloid-Derived Suppressor Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D010641:Phenotype; D015398:Signal Transduction / Q000187:drug effects; D019139:Tumor Escape / Q000187:drug effects*; D059016:Tumor Microenvironment
chemical_list: D000970:Antineoplastic Agents
keywords: Anticancer; Chemo-immunotherapy; Lung cancer; MDSCs; NSCLC; SCLC