title: Risk factors, topographic patterns and mechanism analysis of intracranial atherosclerotic stenosis ischemic stroke.
abstract: BACKGROUND
  The association between topographic patterns, risk factors and stroke mechanisms of ICAS in first-ever stroke remains unknown.
  
  
  METHODS
  A large sample sized retrospective study was performed on first-ever ICAS ischemic stroke using DWI and MRA.
  
  
  RESULTS
  Hypertension (60.92%), cigarette smoking (26.82%), MCA (76.65%) and multiple vessels (65.37%) stenosis, were the major factors favoring different mechanisms. Subcortical lesions were the most occurring topographic patterns (41.4%). The common mechanism was LBO (66.3%). Statistical analysis showed a significant relationship between lesion patterns and mechanisms (r = 0.384, P = 0.001). Single mechanism had the higher apoB/apoAI ratio (P = 0.005) and levels of plasma apoB (P = 0.007) compared with multiple mechanisms. The anterior circulation stroke were more multiple mechanisms as compared to the posterior circulation stroke (P = 0.001). LBO was more prevalent in posterior circulation stroke than in anterior circulation stroke (P = 0.001).
  
  
  CONCLUSIONS
  The topographic patterns of ischemic lesions is helpful in early identification of different mechanisms of ICAS. Monitoring apoB and apoB/apoA1 may help to predict the mechanism of stroke with ICAS. The prevalence of mechanisms differ between anterior and posterior circulation stroke with ICAS.
authors.affiliation: a 1 Department of Neurology , The Affiliated Hospital of Weifang Medical University , Weifang , China.
authors.forename: Yanqiang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: b 2 Department of Neurology , The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.
authors.forename: Zhengqi
authors.initials: Z
authors.lastname: Lu
authors.affiliation: c 3 Department of Neurology , The Affiliated Hospital of Medical College, Qingdao University , Qingdao , China.
authors.forename: Shaoyang
authors.initials: S
authors.lastname: Sun
authors.affiliation: b 2 Department of Neurology , The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.affiliation: b 2 Department of Neurology , The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.
authors.forename: Bingjun
authors.initials: B
authors.lastname: Zhang
authors.affiliation: d 4 Department of Radiology , The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Kang
authors.affiliation: b 2 Department of Neurology , The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.
authors.forename: Xueqiang
authors.initials: X
authors.lastname: Hu
authors.affiliation: b 2 Department of Neurology , The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Dai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology; D018810:Magnetic Resonance Angiography; D008297:Male; D008659:Metabolic Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology; D008875:Middle Aged; D020769:Posterior Cerebral Artery; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology
keywords: DWI; intracranial atherosclerotic stenosis; ischemic stroke; risk factors; stroke mechanisms; topographic lesion patterns