title: Combination of soya protein and polydextrose reduces energy intake and glycaemic response via modulation of gastric emptying rate, ghrelin and glucagon-like peptide-1 in Chinese.
abstract: The short-term effect of soya protein, polydextrose and their combination on energy intake (EI) was investigated in Chinese. In total, twenty-seven healthy, normotensive and lean Chinese men aged 21-40 years were given four different soyabean curd preloads with or without polydextrose. The study was a repeated-measure, randomised, cross-over design. The consumption of high-protein soyabean curd alone or in addition with polydextrose as a preload led to greater reduction in EI at a subsequent meal. A similar observation was also found after intake of low-protein soyabean curd with polydextrose. The gut hormone responses mirrored the reduction in food intake. It appears that incorporation of polydextrose either with low- or high-protein soyabean curd could be a potential strategy to reduce EI and assist with weight management. The popular consumption of soyabean curd in Chinese makes it an ideal vehicle for incorporation of polydextrose. This evidence-based dietary approach can serve as a guideline for developing functional foods for weight reduction and weight maintenance.
authors.affiliation: 1Clinical Nutrition Research Centre (CNRC),Singapore Institute for Clinical Sciences,14 Medical Drive,#07-02,Singapore 117599,Singapore.
authors.forename: Yean Yean
authors.initials: YY
authors.lastname: Soong
authors.affiliation: 1Clinical Nutrition Research Centre (CNRC),Singapore Institute for Clinical Sciences,14 Medical Drive,#07-02,Singapore 117599,Singapore.
authors.forename: Wen Xin
authors.initials: WX
authors.lastname: Lim
authors.affiliation: 1Clinical Nutrition Research Centre (CNRC),Singapore Institute for Clinical Sciences,14 Medical Drive,#07-02,Singapore 117599,Singapore.
authors.forename: Melvin Khee Shing
authors.initials: MK
authors.lastname: Leow
authors.affiliation: 1Clinical Nutrition Research Centre (CNRC),Singapore Institute for Clinical Sciences,14 Medical Drive,#07-02,Singapore 117599,Singapore.
authors.forename: Phei Ching
authors.initials: PC
authors.lastname: Siow
authors.affiliation: 2Singapore Institute for Clinical Sciences,Agency for Science, Technology and Research (A*STAR),30 Medical Drive,Singapore 117609,Singapore.
authors.forename: Ai Ling
authors.initials: AL
authors.lastname: Teh
authors.affiliation: 1Clinical Nutrition Research Centre (CNRC),Singapore Institute for Clinical Sciences,14 Medical Drive,#07-02,Singapore 117599,Singapore.
authors.forename: Christiani Jeyakumar
authors.initials: CJ
authors.lastname: Henry
mesh_terms: D000328:Adult; D001066:Appetite / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism*; D002681:China; D018592:Cross-Over Studies; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004044:Dietary Proteins / Q000494:pharmacology; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects*; D055951:Functional Food; D005746:Gastric Emptying / Q000187:drug effects*; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D054439:Ghrelin / Q000378:metabolism; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D005936:Glucans / Q000494:pharmacology*; D038321:Glycemic Index; D006801:Humans; D008297:Male; D062407:Meals; D009765:Obesity / Q000178:diet therapy / Q000378:metabolism; D030262:Soybean Proteins / Q000494:pharmacology*; D015431:Weight Loss; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D005768:Gastrointestinal Hormones; D054439:Ghrelin; D005936:Glucans; D030262:Soybean Proteins; D052216:Glucagon-Like Peptide 1; C033375:polydextrose
keywords: EI energy intake; Food intake; GER gastric emptying rate; GLP-1 plasma glucagon-like peptide-1; GR glycaemic response; Gastric emptying; Gut hormones; HP high protein; HPP high protein with polydextrose; IAUC incremental AUC; LP low protein; LPP low protein with polydextrose; Polydextrose; Soyabean curd; VAS visual analogue scales