title: Hollow periodic mesoporous organosilica nanospheres by a facile emulsion approach.
abstract: Periodic mesoporous organosilicas (PMOs) with homogeneously incorporated organic groups, highly ordered mesopores, and controllable morphology have attracted increasing attention. In this work, one-step emulsion approach for preparation of hollow periodic mesoporous organosilica (HPMO) nanospheres has been established. The method is intrinsically simple and does not require any sacrificial templates, corrosive and toxic etching agents. The obtained HPMO nanospheres have high surface area (∼950m(2)g(-1)), accessible ordered mesochannels (∼3.4nm), large pore volume (∼3.96cm(3)g(-1)), high condensation degree (77%), and diameter (∼560nm), hollow chamber size (∼400nm), and shell thickness (∼80nm). Furthermore, cytotoxicity show the cell viability is higher than 86% after incubating with the HPMO nanospheres at a concentration of up to 1200μgmL(-1) for 24h. The hemolysis of HPMO nanospheres is lower than 1.1% at concentrations ranging from 10 to 2000μgmL(-1). The lower hemolysis and cytotoxicity make the HPMO nanospheres great promise for future biomedical applications.
authors.affiliation: School of Optoelectronic Engineering, Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210023, PR China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Ma
authors.affiliation: Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210046, PR China.
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210046, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Dang
authors.affiliation: Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210046, PR China.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210046, PR China.
authors.forename: Zenzen
authors.initials: Z
authors.lastname: Tu
authors.affiliation: Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210046, PR China.
authors.forename: Lihui
authors.initials: L
authors.lastname: Yuwen
authors.affiliation: Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, PR China.
authors.forename: Guotao
authors.initials: G
authors.lastname: Chen
authors.affiliation: Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210046, PR China. Electronic address: iamxdsu@njupt.edu.cn.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Su
authors.affiliation: Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, PR China. Electronic address: zhaogangteng@163.com.
authors.forename: Zhaogang
authors.initials: Z
authors.lastname: Teng
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004655:Emulsions / Q000737:chemistry; D006461:Hemolysis; D006801:Humans; D054118:Nanospheres / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D004655:Emulsions; D017646:Organosilicon Compounds
keywords: Biocompatibility; Emulsion approach; Hollow structure; Mesoporous materials; Periodic mesoporous organosilica