title: Plasma Corin as a Predictor of Cardiovascular Events in Patients With Chronic Heart Failure.
abstract: The aim of this study was to determine the prognostic value of plasma corin in patients with chronic heart failure (CHF).
  
  
  
  In recent years, accumulating evidence has indicated that corin plays a critical role in regulating blood pressure and cardiac function.
  
  
  
  We enrolled 1,148 consecutive CHF patients in a prospective cohort study and explored the association between plasma corin levels and clinical prognosis using multivariate Cox regression analysis.
  
  
  
  Patients with low corin levels (<458 pg/ml) were more likely to be women and to be hypertensive. Low corin was found to be associated with an increase in New York Heart Association (NYHA) functional class and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, and a decrease in left ventricular ejection fraction (LVEF) and the estimated glomerular filtration rate (eGFR). Multivariate Cox regression analysis suggested that log corin was an independent predictor of major adverse cardiac event(s) (MACE) (hazard ratio: 0.62; 95% confidence interval: 0.39 to 0.95), together with age, diabetes, NYHA functional class, LVEF, eGFR, and log NT-proBNP. In addition, log corin was also a significant predictor for cardiovascular death (p = 0.041) and heart failure rehospitalization (p = 0.015) after adjustment for clinical variables and established biomarkers of adverse prognosis. The Kaplan-Meier survival curves showed that low corin was a significant predictor of MACE in patients with NT-proBNP levels above and below the median.
  
  
  
  Our study demonstrates that plasma corin is a valuable prognostic marker of MACE in patients with CHF, independent of established conventional risk factors.
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: zhou-xiang@suda.edu.cn.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Jian-Chang
authors.initials: JC
authors.lastname: Chen
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Du
authors.affiliation: Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Kong
authors.affiliation: Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, China.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Xu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000401:mortality*; D002908:Chronic Disease; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000097:blood*; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012697:Serine Endopeptidases / Q000097:blood*; D013318:Stroke Volume
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; C119812:CORIN protein, human; D012697:Serine Endopeptidases
keywords: chronic heart failure; corin; major adverse cardiac events