title: Implantation rates subsequent to the transfer of embryos produced at different phases during double stimulation of poor ovarian responders.
abstract: To compare the implantation capacity of embryos obtained at different phases of double stimulation (DS) of poor ovarian responders, 153 DS cycles were analysed retrospectively. As part of the DS protocol, antral follicles were stimulated continuously during both the follicular and luteal phases. Fresh embryos obtained in both phases were cryopreserved and transferred in the next artificial cycle. The mean number of oocytes retrieved, MII oocytes and zygotes with two pronuclei was significantly higher for collections during luteal-phase stimulation. Furthermore, the dose of exogenous gonadotropin administered was higher during the luteal phase. The rate of clinical pregnancy and embryo implantation increased progressively from pure follicular phase embryos to mixed embryos to pure luteal phase embryos. Embryos produced during the luteal phase resulted in higher implantation rates.
authors.affiliation: Center for Reproductive Medicine, Xiang-Ya Hospital, Central South University, 87th Xiangya Road, Changsha, Hunan, 410000, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Xiaoyue M
authors.initials: XM
authors.lastname: Guo
authors.affiliation: Center for Reproductive Medicine, Xiang-Ya Hospital, Central South University, 87th Xiangya Road, Changsha, Hunan, 410000, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D002996:Clomiphene / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004477:Ectogenesis / Q000187:drug effects; D004624:Embryo Transfer; D005240:Feasibility Studies; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D005498:Follicular Phase / Q000187:drug effects; D006062:Gonadotropins / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008183:Luteal Phase / Q000187:drug effects; D054315:Oocyte Retrieval; D065851:Ovarian Reserve / Q000187:drug effects; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D017329:Triptorelin Pamoate / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D005300:Fertility Agents, Female; D006062:Gonadotropins; D017329:Triptorelin Pamoate; D002996:Clomiphene; D005640:Follicle Stimulating Hormone