title: Continuous Optimal CPP Based on Minute-by-Minute Monitoring Data: A Study of a Pediatric Population.
abstract: This paper describes the use of minute-by-minute monitoring data to determine continuous optimal cerebral perfusion pressure (CPP) recommendations based on the autoregulatory status of pediatric patients with traumatic brain injury. Data from 79 children were retrospectively studied. Optimal CPP recommendations were obtained for the majority of the first 72 h of monitoring time. Actual CPP close to recommended CPP values was significantly associated with better outcome and was a significant independent predictor of better outcome when considering IMPACT model covariates in multivariate logistic regression.
authors.affiliation: Intensive Care Medicine, University Hospitals Leuven, Leuven, Belgium. Fabian.Guiza@med.kuleuven.be.
authors.forename: Fabian
authors.initials: F
authors.lastname: Güiza
authors.affiliation: Intensive Care Medicine, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Geert
authors.initials: G
authors.lastname: Meyfroidt
authors.affiliation: Paediatric Intensive Care and Neurology, Royal Hospital for Sick Children, Edinburgh, UK.
authors.forename: Tsz-Yan Milly
authors.initials: TY
authors.lastname: Lo
authors.affiliation: Child Life and Health, University of Edinburgh, Edinburgh, UK.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Jones
authors.affiliation: Intensive Care Medicine, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Greet
authors.initials: G
authors.lastname: Van den Berghe
authors.affiliation: Neurosurgery, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Bart
authors.initials: B
authors.lastname: Depreitere
mesh_terms: D062186:Arterial Pressure / Q000502:physiology*; D000070642:Brain Injuries, Traumatic / Q000401:mortality / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002648:Child; D006706:Homeostasis; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology*; D016015:Logistic Models; D008991:Monitoring, Physiologic; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D012815:Signal Processing, Computer-Assisted
keywords: Autoregulation; Cerebral perfusion pressure; Critical care; Pediatric head injury; Signal processing; Traumatic brain injury