title: Synthetic Study of Pactamycin: Enantioselective Construction of the Pactamycin Core with Five Contiguous Stereocenters.
abstract: A synthetic study of pactamycin is described. Enantioselective construction of the aminocyclopentitol core of pactamycin bearing five contiguous stereocenters was achieved based on an organocatalytic asymmetric aziridination of 2-cyclopentene-1-one, a regio- and diastereoselective 1,3-dipolar cycloaddition, and a rhodium-catalyzed C-H amination reaction.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1, Inohana, Chuo-ku, Chiba, 260-8675, Japan.
authors.forename: Mami
authors.initials: M
authors.lastname: Yamaguchi
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1, Inohana, Chuo-ku, Chiba, 260-8675, Japan.
authors.forename: Minami
authors.initials: M
authors.lastname: Hayashi
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1, Inohana, Chuo-ku, Chiba, 260-8675, Japan.
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Hamada
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1, Inohana, Chuo-ku, Chiba, 260-8675, Japan.|Molecular Chirality Research Center, Chiba University , 1-33, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Nemoto