title: Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress.
abstract: Mitochondrial RNR-2 (mt-RNR2, humanin) has been shown to play a role in protecting several types of cells and tissues from the effects of oxidative stress. Humanin (HN) functions through extracellular and intracellular pathways adjusting mitochondrial oxidative phosphorylation and ATP production. Addition of HN improved insulin sensitivity in animal models of diabetes mellitus but no clinical studies have been carried out to measure HN levels in humans associated with hyperglycemia. The plasma levels of HN in participants attending a diabetes complications screening clinic were measured. Clinical history and anthropometric data were obtained from all participants. Plasma levels of HN were measured by a commercial ELISA kit. All data were analyzed applying nonparametric statistics and general linear modeling to correct for age and gender. A significant decrease (P = 0.0001) in HN was observed in the impaired fasting glucose (IFG) group (n = 23; 204.84 ± 92.87 pg mL(-1)) compared to control (n = 58; 124.3 ± 83.91 pg mL(-1)) consistent with an adaptive cellular response by HN to a slight increase in BGL.
authors.affiliation: Department of Biochemistry, Freie Universität Berlin, Berlin, Germany School of Community Health and Centre for Research in Complex Systems, Charles Sturt University, Bathurst, Australia.
authors.forename: Annet
authors.initials: A
authors.lastname: Voigt
authors.affiliation: School of Community Health and Centre for Research in Complex Systems, Charles Sturt University, Bathurst, Australia Division of Cardiology, Australian School of Advanced Medicine, Macquarie University, Sydney, Australia hjelinek@csu.edu.au.
authors.forename: Herbert F
authors.initials: HF
authors.lastname: Jelinek
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005215:Fasting / Q000097:blood*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D015415:Biomarkers; D047908:Intracellular Signaling Peptides and Proteins; C427211:humanin; D005947:Glucose
keywords: Humanin; impaired fasting glucose; mitochondrial adaptation; mt‐RNR2; oxidative stress