title: Review of a non-epithelial tumour of the small bowel after c-kit revolution.
abstract: In this article, we reviewed the case of a patient who was object, in 1999, of a published case report of schwannoma of the jejunal wall. Recently, the patient has been referred to our institution for a mass of the stomach identified by upper gastrointestinal endoscopy. The patient underwent a wedge resection of the stomach and a histopathological diagnosis of GIST of the stomach, based on a positive immunohistochemical staining of c-kit and CD34, was made. In consideration of these findings, we performed immunohistochemistry for c-kit and for CD34 on the previous lesion of the jejunal wall, which resulted strongly positive for CD117 and negative for CD34. A new diagnosis of gastrointestinal stromal tumour (GIST) of jejunal wall with moderate risk of progression was made. The lesion was also classified, according to the AJCC Seventh Edition, as a pT3, pN0, Stage II, GIST. This case shows the importance of a reassessment of the diagnosis of mesenchymal neoplasm of the small intestine made before the development of anti-CD117 antibody for a correct prognostic stratification, a better therapeutic management and a close follow-up, if necessary.
  
  
  BACKGROUND
  Adjuvant therapy, c-kit, GIST Imatinib.
authors.forename: Enrico
authors.initials: E
authors.lastname: Fiori
authors.forename: Daniele
authors.initials: D
authors.lastname: Ferraro
authors.forename: Alessandro
authors.initials: A
authors.lastname: De Cesare
authors.forename: Giovanni
authors.initials: G
authors.lastname: Leone
authors.forename: Cecilia
authors.initials: C
authors.lastname: Barmann
authors.forename: Alberto
authors.initials: A
authors.lastname: Schillaci
authors.forename: Francesco
authors.initials: F
authors.lastname: Borrini
mesh_terms: D000368:Aged; D046152:Gastrointestinal Stromal Tumors / Q000737:chemistry / Q000175:diagnosis*; D006801:Humans; D007580:Jejunal Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D008297:Male; D016609:Neoplasms, Second Primary / Q000737:chemistry / Q000175:diagnosis*; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis
chemical_list: D019009:Proto-Oncogene Proteins c-kit