title: Videodermoscopy compared to reflectance confocal microscopy for the diagnosis of scabies.
abstract: BACKGROUND
  Reflectance confocal microscopy (RCM) and dermoscopy have recently been suggested for non-invasive diagnosis of scabies. However, there are large studies on diagnostic accuracy for scabies only with dermoscopy at low (10×) and high (100-1000×) magnification.
  
  
  OBJECTIVE
  Our study evaluated the diagnostic accuracy, for the diagnosis of scabies, of RCM and videodermoscopy at intermediate (20× and 70×) magnification, which is usually found in commercially available videodermoscopes.
  
  
  METHODS
  Patients with a presumptive diagnosis of scabies were prospectively enrolled during 20 months and examined by RCM and videodermoscopy at intermediate magnification. The specificity of RCM was considered 100% because RCM can identify the anatomical details of the parasites.
  
  
  RESULTS
  A total of 148 patients were enrolled. Videodermoscopy showed a higher sensitivity for scabies than RCM (95% vs. 92%) and a specificity of 97%.
  
  
  CONCLUSIONS
  Videodermoscopy at intermediate magnification, and RCM are both highly accurate for the diagnosis of scabies. If the two devices are available, it would be better to perform videodermoscopy first, that is more sensitive, and then RCM to confirm the diagnosis.
authors.affiliation: Dermatology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: E
authors.initials: E
authors.lastname: Cinotti
authors.affiliation: Dermatology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: B
authors.initials: B
authors.lastname: Labeille
authors.affiliation: Dermatology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: F
authors.initials: F
authors.lastname: Cambazard
authors.affiliation: Dermatology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: A C
authors.initials: AC
authors.lastname: Biron
authors.affiliation: Dermatology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: C
authors.initials: C
authors.lastname: Chol
authors.affiliation: Dermatology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: A
authors.initials: A
authors.lastname: Leclerq
authors.affiliation: Dermatology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: C
authors.initials: C
authors.lastname: Jaffelin
authors.affiliation: Dermatology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Perrot
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D046169:Dermoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D018613:Microscopy, Confocal / Q000379:methods*; D008875:Middle Aged; D012532:Scabies / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D055815:Young Adult