title: Pediatric Lyme Neuroborreliosis: Different clinical presentations of the same agent; Single center experience.
abstract: Lyme disease is a vector-associated infectious disease, caused by the agent, spirochete Borrelia burgdorferi. Neurologic findings are observed in approximately 12% of the cases and termed Lyme neuroborreliosis (LNB). Lyme neuroborreliosis may manifest with different clinical neurologic manifestations.
  
  
  
  The study was conducted at tertiary training and research hospital. From January 2014 to September 2015, a total of 75 patients diagnosed with encephalitis, ataxia, Guillain Barre Syndrome (GBS), facial paralysis, acute disseminated encephalomyelitis (ADEM), pseudotumorcerebri were evaluated for inclusion to the study. Among these patients whom investigations of B. burgdorferi antibody IgM and/or IgG ELISA and Western Blot (WB) were detected to be positive, were assessed. Epidemiologic data, tick bite histories, duration of symptoms, clinical findings, radiologic findings, treatment durations and prognosis were investigated.
  
  
  
  Totally 7 patients had been treated with the diagnosis of Lyme neuroborreliosis. The mean age was 9.14±4.91 years; duration of symptoms before admission was 8.0±4.50 days; and the duration of antibiotic use was 2.85±0.89 weeks. All patients had received ceftriaxone and intravenous immunoglobulin (IVIG); 3 patients had received plasmapheresis (42.9%) and one patient had received pulse corticosteroid therapy. While the patient with the diagnosis of encephalomyeloneuritis and atypical GBS had partially improved, the other patients were completely cured.
  
  
  
  In this article, we report pediatric LNB patients, B. burgdorferi should also be considered in patients with atypical or severe neurologic involvement or a history of tick bite; it is known that the prognosis is good with appropriate and early treatment.
authors.affiliation: Pediatric Neurology, Adana Numune Research and Training Hospital, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Celik
authors.affiliation: Pediatric Infection, Adana Numune Research and Training Hospital, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Celik
authors.affiliation: Pediatric Neurology, Adana Numune Research and Training Hospital, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kömür
authors.affiliation: Department of Pediatrics, Adana Numune Research and Training Hospital, Turkey.
authors.forename: Orkun
authors.initials: O
authors.lastname: Tolunay
authors.affiliation: Pediatric Intensive Care, Çukurova University Faculty of Medicine, Turkey.
authors.forename: Riza Dincer
authors.initials: RD
authors.lastname: Yildizdas
authors.affiliation: Pediatric Oncology, Adana Numune Research and Training Hospital, Turkey.
authors.forename: Begul
authors.initials: B
authors.lastname: Yagci-Kupeli
authors.affiliation: Department of Pediatrics, Adana Numune Research and Training Hospital, Turkey.
authors.forename: Fulya
authors.initials: F
authors.lastname: Kücük
authors.affiliation: Department of Pediatrics, Adana Numune Research and Training Hospital, Turkey.
authors.forename: İsmail
authors.initials: İ
authors.lastname: Eroglu
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology; D015153:Blotting, Western; D025065:Borrelia burgdorferi / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D020275:Guillain-Barre Syndrome; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D020852:Lyme Neuroborreliosis / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007075:Immunoglobulin M