title: Prognostic value of microRNAs in cervical carcinoma: a systematic review and meta-analysis.
abstract: This systematic review is written to investigate the outcome of cervical cancer. A comprehensive search of PubMed and EMBASE was performed to identify eligible studies. Nineteen studies from thirteen articles with a total of 1,310 participants were included in this meta-analysis. Overall survival (OS), disease-free survival (DFS), and recurrence-free survival (RFS) as a prognosis for cervical cancer were extracted and calculated, if available. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using STATA (version 12.0), resulting in the pooled HRs 0.70 (95% CI: 0.51-0.97) for OS, 1.02 (95% CI: 0.53-1.98) for DFS, and 0.56 (95% CI: 0.40-0.77) for RFS. The results indicated that cervical cancer patients with decreased microRNA expression were associated with shorter OS and RFS. It suggested that microRNAs might be promising markers for predicting the survival rate of cervical cancer.
authors.affiliation: Department of Gynecologic Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Shengkang
authors.initials: S
authors.lastname: Dai
authors.affiliation: Department of Gynecologic Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Gynecologic Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Long
authors.affiliation: Department of Gynecologic Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Yuehua
authors.initials: Y
authors.lastname: Lai
authors.affiliation: Department of Gynecologic Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Du
authors.affiliation: Department of Gynecologic Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Ding
authors.affiliation: Department of Gynecologic Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Desheng
authors.initials: D
authors.lastname: Yao
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000032:analysis*; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000401:mortality
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: cervical carcinoma; meta-analysis; microRNA; prognosis