title: [Adrenocortical carcinoma and pregnancy].
abstract: Adrenocortical carcinoma is a rare cancer with a poor but heterogeneous prognosis. These tumours are more frequently encountered in women, sometimes very young and may be diagnosed in women in their child bearing years or already pregnant. Several clinical data have indicated that the secretion and or proliferation of adrenocortical tumors may be affected by the hormonal context of pregnancy. In this review, we will examine the link between ACC and pregnancy in two main aspects. We will first consider the situation of a pregnant woman with a clinical suspicion of adrenocortical carcinoma: which diagnostic procedures will be useful and safe for the foetus? What are the therapeutic options? What is the prognosis if the diagnosis is confirmed? In a second part, we will examine the possible risk of mothering a child in a patient previously treated for an ACC. The data shown here were obtained from studies carried out in a tertiary reference medical centre in Paris (Hôpital Cochin) and from the European Network for the Study of Adrenal Tumor (ENS@T) database of adrenocortical carcinoma.
authors.affiliation: Service d'endocrinologie-nutrition, hôpital Ambroise-Paré, 9, avenue Charles-de-Gaulle, 92100 Boulogne, France; Inserm U1173, université Versailles-Saint-Quentin, 2, avenue de la Source de la Bièvre, 78180 Montigny-Le-Bretonneux, France. Electronic address: marie-laure.raffin-sanson@aphp.fr.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Raffin-Sanson
authors.affiliation: Department of Endocrinology, Cochin University Hospital, AP-HP, French Adrenal Cancer Network COMETE-Cancer, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; UMR 8104, institut Cochin, Paris, France.
authors.forename: Gwenaelle
authors.initials: G
authors.lastname: Abiven
authors.affiliation: Medizinische Klinik IV, Klinikum der Universität München, Munich, Allemagne.
authors.forename: Katrin
authors.initials: K
authors.lastname: Ritzel
authors.affiliation: Service d'endocrinologie-nutrition, hôpital Ambroise-Paré, 9, avenue Charles-de-Gaulle, 92100 Boulogne, France; Inserm U1173, université Versailles-Saint-Quentin, 2, avenue de la Source de la Bièvre, 78180 Montigny-Le-Bretonneux, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: de Corbière
authors.affiliation: Service d'endocrinologie-nutrition, hôpital Ambroise-Paré, 9, avenue Charles-de-Gaulle, 92100 Boulogne, France; Inserm U1173, université Versailles-Saint-Quentin, 2, avenue de la Source de la Bièvre, 78180 Montigny-Le-Bretonneux, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Cazabat
authors.affiliation: Service d'endocrinologie-nutrition, hôpital Ambroise-Paré, 9, avenue Charles-de-Gaulle, 92100 Boulogne, France; Inserm U1173, université Versailles-Saint-Quentin, 2, avenue de la Source de la Bièvre, 78180 Montigny-Le-Bretonneux, France.
authors.forename: Ramona
authors.initials: R
authors.lastname: Zaharia
authors.affiliation: Department of Endocrinology, Cochin University Hospital, AP-HP, French Adrenal Cancer Network COMETE-Cancer, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; UMR 8104, institut Cochin, Paris, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Groussin
authors.affiliation: Department of Endocrinology, Cochin University Hospital, AP-HP, French Adrenal Cancer Network COMETE-Cancer, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; UMR 8104, institut Cochin, Paris, France.
authors.forename: Rossella
authors.initials: R
authors.lastname: Libe
authors.affiliation: Department of Endocrinology, Cochin University Hospital, AP-HP, French Adrenal Cancer Network COMETE-Cancer, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; UMR 8104, institut Cochin, Paris, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Bertherat
authors.affiliation: Medizinische Klinik IV, Klinikum der Universität München, Munich, Allemagne.
authors.forename: Martin
authors.initials: M
authors.lastname: Fassnacht
authors.affiliation: Department of Endocrinology, Cochin University Hospital, AP-HP, French Adrenal Cancer Network COMETE-Cancer, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; UMR 8104, institut Cochin, Paris, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Bertagna
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000628:therapy; D018268:Adrenocortical Carcinoma / Q000175:diagnosis / Q000628:therapy; D003940:Diagnostic Techniques, Endocrine / Q000009:adverse effects; D005260:Female; D006801:Humans; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000628:therapy; D011296:Prenatal Diagnosis / Q000009:adverse effects / Q000379:methods; D011379:Prognosis
keywords: Adrenocortical carcinoma; Corticosurrénalome; Grossesse; Pregnancy; Prognosis; Pronostic