title: N-acetylcysteine eradicates Pseudomonas aeruginosa biofilms in bone cement.
abstract: Biofilm is an example of bacterial group behavior. We investigated the effect of N-acetylcysteine (NAC) alone and in combination with ciprofloxacin on Pseudomonas aeruginosa biofilm formation. Four groups (each contains six molds) of standardized bone cement molds were infected. NAC, ciprofloxacin each alone, and NAC/ciprofloxacin combination were evaluated in point of inhibiting and eradicating biofilm capacity using microbiological and electron microscopical evaluation techniques. Microbial counts and electron microscopical observations showed that the effect of NAC and ciprofloxacin combination on biofilm formation in bone cement is valuable. NAC enhances the beneficial effect of ciprofloxacin when used in combination with it in bone cement. SCANNING 38:766-770, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Histology and Embryology, Medical School, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Onger
authors.affiliation: Department of Orthopedics and Traumatology, Medical School, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Gocer
authors.affiliation: Department of Medical Microbiology, Medical School, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Emir
authors.affiliation: Department of Histology and Embryology, Medical School, Ondokuz Mayis University, Samsun, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Kaplan
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D001843:Bone Cements; D002939:Ciprofloxacin / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D001843:Bone Cements; D002939:Ciprofloxacin; D000111:Acetylcysteine
keywords: N-acetylcysteine; SEM; biofilm; bone sement; ciproflaxacin