title: Quantification of retinal layer thickness changes in acute macular neuroretinopathy.
abstract: To quantitatively evaluate retinal layer thickness changes in acute macular neuroretinopathy (AMN).
  
  
  
  AMN areas were identified using near-infrared reflectance (NIR) images. Intraretinal layer segmentation using Heidelberg software was performed. The inbuilt ETDRS -grid was moved onto the AMN lesion and the mean retinal layer thicknesses of the central grid were recorded and compared with the corresponding area of the fellow eye at initial presentation and during follow-up.
  
  
  
  Eleven patients were included (mean age 26±6 years). AMN lesions at baseline had a significantly thinner outer nuclear layer (ONL) (51±21 µm vs 73±17 µm, p=0.002). The other layers, including inner nuclear layer (37±8 µm vs 38±6 µm, p=0.9) and outer plexiform layer (OPL) (45±19 µm vs 33±16 µm, p=0.1) did not show significant differences between the study eyes and fellow eyes. Adjacent to NIR image lesions, areas of OPL thickening were identified (study eye: 50±14 µm vs fellow eye: 39±16 µm, p=0.005) with corresponding thinning of ONL (study eye: 52±16 µm vs fellow eye: 69±16 µm, p=0.002).
  
  
  
  AMN presents with characteristic quantitative retinal changes and the extent of the lesion may be more extensive than initially presumed from NIR image lesions.
authors.affiliation: Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Switzerland.|Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.|Bern Photographic Reading Center, Inselspital, Bern University Hospital, University of Bern, Switzerland.
authors.forename: Marion R
authors.initials: MR
authors.lastname: Munk
authors.affiliation: Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Switzerland.
authors.forename: Marco
authors.initials: M
authors.lastname: Beck
authors.affiliation: Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Switzerland.
authors.forename: Simone
authors.initials: S
authors.lastname: Kolb
authors.affiliation: Department of Ophthalmology, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark.
authors.forename: Michael
authors.initials: M
authors.lastname: Larsen
authors.affiliation: Department of Ophthalmology, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark.
authors.forename: Steffen
authors.initials: S
authors.lastname: Hamann
authors.affiliation: Department of Ophthalmology, Kantonspital St. Gallen, St. Gallen, Switzerland.
authors.forename: Christophe
authors.initials: C
authors.lastname: Valmaggia
authors.affiliation: Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Switzerland.|Bern Photographic Reading Center, Inselspital, Bern University Hospital, University of Bern, Switzerland.|Department of Clinical Research, Inselspital, Bern University Hospital, University of Bern, Switzerland.
authors.forename: Martin S
authors.initials: MS
authors.lastname: Zinkernagel
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D012160:Retina / Q000502:physiology*; D012164:Retinal Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity; D055815:Young Adult
keywords: Imaging; Macula