title: Interdisciplinary Parkinson's Disease Deep Brain Stimulation Screening and the Relationship to Unintended Hospitalizations and Quality of Life.
abstract: To investigate the impact of pre-operative deep brain stimulation (DBS) interdisciplinary assessments on post-operative hospitalizations and quality of life (QoL).
  
  
  
  DBS has been utilized successfully in Parkinson's disease (PD) for the treatment of tremor, rigidity, bradykinesia, off time, and motor fluctuations. Although DBS is becoming a more common management approach there are no standardized criteria for selection of DBS candidates, and sparse data exist to guide the use of interdisciplinary evaluations for DBS screening. We reviewed the outcomes of the use of an interdisciplinary model which utilized seven specialties to pre-operatively evaluate potential DBS candidates.
  
  
  
  The University of Florida (UF) INFORM database was queried for PD patients who had DBS implantations performed at UF between January 2011 and February 2013. Records were reviewed to identify unintended hospitalizations, falls, and infections. Minor and major concerns or reservations from each specialty were previously documented and quantified. Clinical outcomes were assessed through the use of the Parkinson disease quality of life questionnaire (PDQ-39), and the Unified Parkinson's Disease Rating Score (UPDRS) Part III.
  
  
  
  A total of 164 cases were evaluated for possible DBS candidacy. There were 133 subjects who were approved for DBS surgery (81%) following interdisciplinary screening. There were 28 cases (21%) who experienced an unintended hospitalization within the first 12 months following the DBS operation. The patients identified during interdisciplinary evaluation with major or minor concerns from any specialty service had more unintended hospitalizations (93%) when compared to those without concerns (7%). When the preoperative "concern" shifted from "major" to "minor" to "no concerns," the rate of hospitalization decreased from 89% to 33% to 3%. A strong relationship was uncovered between worsened PDQ-39 at 12 months and increased hospitalization.
  
  
  
  Unintended hospitalizations and worsened QOL scores correlated with the number and severity of concerns raised by interdisciplinary DBS evaluations. The data suggest that detailed screenings by interdisciplinary teams may be useful for more than just patient selection. These evaluations may help to stratify risk for post-operative hospitalization and QoL outcomes.
authors.affiliation: Department of Neurology, University of Florida College of Medicine, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States of America.
authors.forename: Masa-Aki
authors.initials: MA
authors.lastname: Higuchi
authors.affiliation: Department of Neurology, University of Florida College of Medicine, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States of America.
authors.forename: Daniel
authors.initials: D
authors.lastname: Martinez-Ramirez
authors.affiliation: Department of Neurology, University of Florida College of Medicine, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States of America.
authors.forename: Hokuto
authors.initials: H
authors.lastname: Morita
authors.affiliation: Department of Neurology, University of Florida College of Medicine, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States of America.
authors.forename: Dan
authors.initials: D
authors.lastname: Topiol
authors.affiliation: Department of Clinical and Health Psychology, University of Florida College of Public Health and Health Professions, Gainesville, Florida, United States of America.
authors.forename: Dawn
authors.initials: D
authors.lastname: Bowers
authors.affiliation: Department of Psychiatry, University of Florida College of Medicine, Gainesville, Florida, United States of America.
authors.forename: Herbert
authors.initials: H
authors.lastname: Ward
authors.affiliation: Rehabilitation Services, University Florida Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States of America.
authors.forename: Lisa
authors.initials: L
authors.lastname: Warren
authors.affiliation: Rehabilitation Services, University Florida Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States of America.
authors.forename: Meredith
authors.initials: M
authors.lastname: DeFranco
authors.affiliation: Department of Speech, Language, and Hearing Sciences, University of Florida College of Public Health and Health Professions, Gainesville, Florida, United States of America.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Hicks
authors.affiliation: Department of Speech, Language, and Hearing Sciences, University of Florida College of Public Health and Health Professions, Gainesville, Florida, United States of America.
authors.forename: Karen W
authors.initials: KW
authors.lastname: Hegland
authors.affiliation: Department of Speech, Language, and Hearing Sciences, University of Florida College of Public Health and Health Professions, Gainesville, Florida, United States of America.
authors.forename: Michelle S
authors.initials: MS
authors.lastname: Troche
authors.affiliation: Rehabilitation Services, University Florida Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States of America.
authors.forename: Shankar
authors.initials: S
authors.lastname: Kulkarni
authors.affiliation: Department of Neurology, University of Florida College of Medicine, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States of America.
authors.forename: Erin
authors.initials: E
authors.lastname: Hastings
authors.affiliation: Department of Neurosurgery, University of Florida College of Medicine, Gainesville, Florida, United States of America.
authors.forename: Kelly D
authors.initials: KD
authors.lastname: Foote
authors.affiliation: Department of Neurology, University of Florida College of Medicine, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States of America.|Department of Neurosurgery, University of Florida College of Medicine, Gainesville, Florida, United States of America.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Okun
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D011788:Quality of Life