title: One-pot fabricating Fe3O4/graphene nanocomposite with excellent biocompatibility and non-toxicity as a negative MR contrast agent.
abstract: We report a facile approach to synthesize water-dispersible nanocomposite with Fe3O4 nanoparticles (NPs) attached to graphene (G), which combines the growth of Fe3O4NPs and the reduction of graphene oxide (GO) in one single step. The unique hydrophilic surface structure of Fe3O4/G nanocomposite leads to it being colloidally stable, non-cytotoxic, well-dispersible and biocompatible in aqueous solution verified via bio-experiments. In vivo tests also prove that Fe3O4/G nanocomposite, which can be cleared from the body through the metabolic processes, is harmless to the living body. Most importantly, the Fe3O4/G nanocomposite showed T2relaxivity (123.04mM(-1)s(-1)) indicating its potential as a sensitive T2 contrast agent.
authors.affiliation: Key Laboratory of Automobile Materials, Ministry of Education and School of Materials Science and Engineering, Jilin University, Changchun 130022, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zan
authors.affiliation: Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Sun
authors.affiliation: Key Laboratory of Automobile Materials, Ministry of Education and School of Materials Science and Engineering, Jilin University, Changchun 130022, China. Electronic address: lijunzhao@jlu.edu.cn.
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors.forename: Zhongwen
authors.initials: Z
authors.lastname: Lv
authors.affiliation: Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun 130033, China. Electronic address: hyq2@sina.com.
authors.forename: Yuquan
authors.initials: Y
authors.lastname: He
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D048430:Cell Shape / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry*; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D057446:Hydrodynamics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008810:Mice, Inbred C57BL; D053761:Nanocomposites / Q000737:chemistry*; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D055672:Static Electricity; D013696:Temperature; D014018:Tissue Distribution / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide; D006108:Graphite
keywords: Excellent biocompatibility; Fe(3)O(4)/graphene nanocomposite; Negative MR contrast agent; Non-toxicity