title: PARK16 is associated with PD in the Malaysian population.
abstract: PARK16 was identified as a risk factor for Parkinson's disease in a Japanese cohort; however, subsequent studies in the other populations including the Chinese, European, Caucasian, and Chilean have shown a protective role instead. To investigate this locus in our Malaysian cohort, 1,144 individuals were screened for five SNPs in the PARK16 locus and logistic regression analysis showed that the A allele of the rs947211 SNP reduced the risk of developing PD via a recessive model (Odds ratio 0.57, P-value 0.0003). Pooled analysis with other Asian studies showed that A allele of the rs947211 SNP decreased the risk of developing PD via a recessive model (Odds ratio 0.71, P-value 0.0001). In addition, when meta-analysis was performed with other Asian population, three SNPs (rs823128, rs823156, and rs11240572) reduced risk of developing PD via a dominant model. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Faculty of Medicine, Department of Biomedical Science, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Aroma Agape
authors.initials: AA
authors.lastname: Gopalai
authors.affiliation: Faculty of Medicine, Department of Biomedical Science, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Azlina
authors.initials: A
authors.lastname: Ahmad-Annuar
authors.affiliation: Health Services Research, Singapore General Hospital, Singapore, Singapore.
authors.forename: Hui-Hua
authors.initials: HH
authors.lastname: Li
authors.affiliation: Department of Clinical Research, Singapore General Hospital, Singapore, Singapore.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Faculty of Medicine, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Shen-Yang
authors.initials: SY
authors.lastname: Lim
authors.affiliation: Faculty of Medicine, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Ai Huey
authors.initials: AH
authors.lastname: Tan
authors.affiliation: Island Hospital, Pulau Pinang, George Town, Malaysia.
authors.forename: Thien Thein
authors.initials: TT
authors.lastname: Lim
authors.affiliation: Department of Neurology, Hospital Pulau Pinang, Penang, Malaysia.
authors.forename: Gaik Bee
authors.initials: GB
authors.lastname: Eow
authors.affiliation: Department of Neurology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
authors.forename: Puvanarajah
authors.initials: P
authors.lastname: Santhi
authors.affiliation: Department of Neurology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Shanthi
authors.affiliation: Hospital University Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Mohamed Ibrahim
authors.initials: MI
authors.lastname: Norlinah
authors.affiliation: Department of Medicine, Hospital Sultanah Nur Zahirah, Kuala Terengganu, Malaysia.
authors.forename: Zariah Abdul
authors.initials: ZA
authors.lastname: Aziz
authors.affiliation: Faculty of Medicine, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Soo Kun
authors.initials: SK
authors.lastname: Lim
authors.affiliation: Faculty of Medicine, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Chong Tin
authors.initials: CT
authors.lastname: Tan
authors.affiliation: Department of Neurology, Singapore General Hospital, Singapore, Singapore.|National Neuroscience Institute and Duke-NUS Graduate Medical School, Singapore.
authors.forename: Eng-King
authors.initials: EK
authors.lastname: Tan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005006:Ethnicity; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors
keywords: Malaysia; PARK16; Parkinson's disease; genetics; meta-analysis