title: Antihyperglycemic effect of Persea duthieion blood glucose levels and body weight in alloxan induced diabetic rabbits.
abstract: The present study was designed to investigate the antihyperglycemic effect of Persea duthieion blood glucose concentration and body weight in alloxan induced diabetic hyperglycemic rabbits. The results illustrated significant antihyperglycemic activity of crude extract with 17.44% and 28.02% amelioration at 25 and 50mg/kg p.o. respectively after 24th day of drug treatment; equally supported by body weight recovery. Upon fractionation, most dominant antihyperglycemic effect was displayed by aqueous fraction with 22.12% and 34.43% effect followed by ethyl acetate fraction with 24.32% and 32.05% effect at 25 and 50mg/kg p.o. respectively after 24th day of drug treatment. The effect on blood glucose was also reflected on body weight of animals. In conclusion, our study documented marked antihyperglycemic activity of extract/fractions of P. duthiei.
authors.affiliation: Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
authors.forename: Khushbakht
authors.initials: K
authors.lastname: Sultan
authors.affiliation: Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zakir
authors.affiliation: Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Pakistan.
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.affiliation: Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
authors.forename: Ihsaan Ullah
authors.initials: IU
authors.lastname: Khan
authors.affiliation: Department of Zoology, Kohat University of Science & Technology, Kohat, Pakistan.
authors.forename: Sultan
authors.initials: S
authors.lastname: Ayaz
authors.affiliation: Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
authors.forename: Iqbal
authors.initials: I
authors.lastname: Khan
authors.affiliation: College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University Mardan, Pakistan.
authors.forename: Jafar
authors.initials: J
authors.lastname: Khan
authors.affiliation: Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
authors.forename: Murad Ali
authors.initials: MA
authors.lastname: Khan
mesh_terms: D000085:Acetates / Q000737:chemistry; D000496:Alloxan; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects*; D005591:Chemical Fractionation; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D027421:Persea / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D011817:Rabbits; D012997:Solvents / Q000737:chemistry; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D000085:Acetates; D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D000496:Alloxan; C007650:ethyl acetate