title: Biochemical Response to a Moderate Running Bout in Participants With or Without a History of Acute Knee Injury.
abstract: BACKGROUND
  Individuals with an acute knee-injury history are 4 times more likely to develop knee osteoarthritis than those without a prior knee injury, and it is unknown why. Individuals with an injury history may exhibit aberrant changes in tissue turnover after physical activity (eg, running), which could lead to osteoarthritis, but this has yet to be determined among young, physically active individuals.
  
  
  OBJECTIVE
  To determine collagen degradation and synthesis and inflammatory biomarker concentration levels before exercise and changes in response to an acute running bout in injured participants compared with healthy control participants.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  Research laboratory.
  
  
  METHODS
  A total of 22 physically active individuals between 18 and 25 years of age were recruited for the study: 11 injured participants (knee injury within 4 years of the study) who were medically cleared for physical activity and 11 matched healthy control participants.
  
  
  METHODS
  The independent variable was group (injured or control). Dependent variables were serum biomarker concentrations for cartilage oligomeric matrix protein, matrix metalloproteinase-13, proinflammatory marker interleukin-1β, c-terminal cross-linking telopeptide of type II collagen, and type II collagen synthesis marker. Each participant provided prerun and postrun blood samples for biomarker-concentration analysis.
  
  
  RESULTS
  No group differences existed in serum biomarker concentrations before exercise or in serum biomarker changes from pre-exercise to postexercise.
  
  
  CONCLUSIONS
  After an acute bout of moderate-intensity running, young, active individuals in a high-risk postinjury population had similar biochemical responses as matched healthy controls. However, the external generalizability of these findings to other exercises and populations has yet to be determined.
authors.affiliation: West Chester University of Pennsylvania.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Cattano
authors.affiliation: Division of Rheumatology, Tufts Medical Center, Boston, MA.
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Driban
authors.affiliation: Temple University, Philadelphia, PA.
authors.forename: Mary F
authors.initials: MF
authors.lastname: Barbe
authors.affiliation: Temple University, Philadelphia, PA.
authors.forename: Ryan T
authors.initials: RT
authors.lastname: Tierney
authors.affiliation: Temple University, Philadelphia, PA.
authors.forename: Mamta
authors.initials: M
authors.lastname: Amin
authors.affiliation: Temple University, Philadelphia, PA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Sitler
mesh_terms: D015415:Biomarkers / Q000097:blood; D064236:Cartilage Oligomeric Matrix Protein / Q000097:blood; D016022:Case-Control Studies; D015331:Cohort Studies; D024043:Collagen Type II / Q000097:blood; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D007718:Knee Injuries / Q000097:blood* / Q000503:physiopathology*; D008297:Male; D053509:Matrix Metalloproteinase 13 / Q000097:blood; D020370:Osteoarthritis, Knee / Q000209:etiology / Q000503:physiopathology; D012420:Running / Q000502:physiology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; D024043:Collagen Type II; D053583:Interleukin-1beta; D053509:Matrix Metalloproteinase 13; C507079:MMP13 protein, human; C577553:TSP5 protein, human
keywords: anterior cruciate ligament; biological markers; collagen; osteoarthritis; serum