title: Association between interleukin-10 gene polymorphisms and susceptibility to diabetic nephropathy in a Chinese population.
abstract: In this study, we investigated the association between the interleukin (IL)-10 -592C/A, -819C/T, and -1082G/A genetic variations and susceptibility to diabetic nephropathy in a Chinese population. The IL-10 -592C/A, -819C/T, and -1082G/A polymorphisms were genotyped in diabetic nephropathy patient and control samples by polymerase chain reaction-restriction fragment length polymorphism. The results were then statistically analyzed using SPSS 17.0. The results of the χ(2) test revealed a significant difference in the frequencies of the GG, GA, and AA genotypes of IL-10 -1082G/A between patients with diabetic nephropathy and control subjects (χ(2) = 10.03, P = 0.007). Unconditional logistic regression analysis revealed that the AA genotype of IL-10 -1082G/A significantly increased the susceptibility to diabetic nephropathy [adjusted odds ratio (OR) = 2.52, 95% confidence interval (CI) = 1.31-4.82] compared to the wild-type genotype. Moreover, the A allele of this polymorphism was associated with an increased risk of diabetic nephropathy compared to the G allele (adjusted OR = 1.51, 95%CI = 1.15-1.99). However, the IL-10 -819T/C and -592A/C genetic polymorphisms did not increase the risk of diabetic nephropathy. In conclusion, the IL-10 -1082G/A polymorphism was found to be correlated with the development of diabetic nephropathy.
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China.
authors.forename: D H
authors.initials: DH
authors.lastname: Ma
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China.
authors.forename: Q Y
authors.initials: QY
authors.lastname: Xu
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Endocrinology & Metabolism, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China.
authors.forename: Q Q
authors.initials: QQ
authors.lastname: Zhai
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China.
authors.forename: M H
authors.initials: MH
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D003928:Diabetic Nephropathies / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10