title: Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response.
abstract: Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome. Stress is known to influence the immune system and can exacerbate the sickness response. Although a role for psychological stress in the sickness response, particularly in combination with EBV-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase) has been established, and the role of physical stressors in these interactions remains unspecified. In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection. We hypothesize that a chronic physical stressor will exacerbate the sickness response following EBV-encoded dUTPase injection. To test this hypothesis mice receive daily injections of EBV-encoded dUTPase or vehicle and are subjected to 15 min of swim stress each day for 14 days or left unmanipulated. On the final evening of injections mice undergo behavioral testing. EBV-encoded dUTPase injection alone produces some sickness behaviors. The physical swimming stress does not alter the sickness response.
authors.affiliation: Departments of Neuroscience, The Ohio State University, Columbus, OH, USA.
authors.forename: Taryn G
authors.initials: TG
authors.lastname: Aubrecht
authors.affiliation: Departments of Neuroscience, The Ohio State University, Columbus, OH, USA.
authors.forename: Zachary M
authors.initials: ZM
authors.lastname: Weil
authors.affiliation: Departments of Neuroscience, The Ohio State University, Columbus, OH, USA.
authors.forename: Bachir
authors.initials: B
authors.lastname: Abi Salloum
authors.affiliation: Molecular Virology, Immunology & Medical Genetics, The Ohio State University, Columbus, OH, USA.
authors.forename: Maria Eugenia
authors.initials: ME
authors.lastname: Ariza
authors.affiliation: Molecular Virology, Immunology & Medical Genetics, The Ohio State University, Columbus, OH, USA.
authors.forename: Marshall
authors.initials: M
authors.lastname: Williams
authors.affiliation: Institute of Behavioral Medicine Research, Wexner Medical Center, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
authors.forename: Brenda
authors.initials: B
authors.lastname: Reader
authors.affiliation: Molecular Virology, Immunology & Medical Genetics, The Ohio State University, Columbus, OH, USA; Institute of Behavioral Medicine Research, Wexner Medical Center, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
authors.forename: Ronald
authors.initials: R
authors.lastname: Glaser
authors.affiliation: Institute of Behavioral Medicine Research, Wexner Medical Center, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, USA.
authors.forename: John
authors.initials: J
authors.lastname: Sheridan
authors.affiliation: Departments of Neuroscience, The Ohio State University, Columbus, OH, USA.
authors.forename: Randy J
authors.initials: RJ
authors.lastname: Nelson
keywords: Epstein-Barr Virus; Sickness Response; Swim Stress