title: Recent advances in research on lignans and neolignans.
abstract: Covering: 2009 to 2015Lignans and neolignans are a large group of natural products derived from the oxidative coupling of two C6-C3 units. Owing to their biological activities ranging from antioxidant, antitumor, anti-inflammatory to antiviral properties, they have been used for a long time both in ethnic as well as in conventional medicine. This review describes 564 of the latest examples of naturally occurring lignans and neolignans, and their glycosides in some cases, which have been isolated between 2009 and 2015. It comprises the data reported in more than 200 peer-reviewed articles and covers their source, isolation, structure elucidation and bioactivities (where available), and highlights the biosynthesis and total synthesis of some important ones.
authors.affiliation: Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, 44221 Dortmund, Germany. michael.spiteller@tu-dortmund.de and Department of Chemistry, Faculty of Science, University of Dschang, P. O. Box 67, Dschang, Cameroon.
authors.forename: Rémy Bertrand
authors.initials: RB
authors.lastname: Teponno
authors.affiliation: Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, 44221 Dortmund, Germany. michael.spiteller@tu-dortmund.de.
authors.forename: Souvik
authors.initials: S
authors.lastname: Kusari
authors.affiliation: Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, 44221 Dortmund, Germany. michael.spiteller@tu-dortmund.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Spiteller
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D006678:HIV / Q000187:drug effects; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D000998:Antiviral Agents; D001688:Biological Products; D006027:Glycosides; D017705:Lignans