title: Quantitative Issues in Response Measurement by PET.
abstract: Monitoring response to anticancer therapy requires a (semi)quantitative PET approach. In this review, several instrumentation and analysis issues that have an impact on quantification are discussed. These issues are divided into the following steps: data acquisition, image reconstruction, image analysis, and data analysis. Although the focus of this review is on FDG, most issues presented apply to all tracers (ie, to PET quantification in general).
authors.affiliation: Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: aa.lammertsma@vumc.nl.
authors.forename: Adriaan A
authors.initials: AA
authors.lastname: Lammertsma
authors.affiliation: Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Ronald
authors.initials: R
authors.lastname: Boellaard
authors.affiliation: Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Otto S
authors.initials: OS
authors.lastname: Hoekstra
keywords: FDG; PET; Quantification; Response monitoring; Tracer kinetic modeling