title: [Long-term efficacy of aspirin desensitization in aspirin-exacerbated respiratory disease. Review of two clinical cases].
abstract: The aspirin exacerbated respiratory disease (AERD) shows a prevalence of 7% among asthmatics and increases to 14% in patients with difficult to control asthma. Treatment includes the use of inhibitors of leukotriene receptor (), intranasal steroids, polypectomy, asthma management according to the severity and avoid taking nonsteroidal anti-inflammatory drugs (NSAIDs). In some patients it is necessary desensitization protocol to it.
  
  
  
  Two patients diagnosed with respiratory disease exacerbated by aspirin, with poor asthma control and need for multiple polypectomies, despite optimal pharmacological management, carrying out protocol desensitization to aspirin (AAS) successful, now after 4 years of having carried out, they have adequate asthma control without need for polypectomies with a maintenance dose of aspirin 150 mg/day.
authors.affiliation: Servicio de Alergia e Inmunología Clínica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, Instituto Mexicano del Seguro Social, México. jcesar_963@hotmail.com.
authors.forename: Julio César
authors.initials: JC
authors.lastname: Cambray-Gutiérrez
authors.forename: Ulises Noel
authors.initials: UN
authors.lastname: García-Ramírez
authors.forename: Leonel Gerardo
authors.initials: LG
authors.lastname: Del Rivero-Hernández
authors.forename: Sean Alejandro
authors.initials: SA
authors.lastname: Lozano-Martínez
authors.forename: Patricia
authors.initials: P
authors.lastname: López-Pérez
authors.forename: Aurora
authors.initials: A
authors.lastname: Chávez-García
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D055963:Asthma, Aspirin-Induced / Q000276:immunology / Q000628:therapy*; D003888:Desensitization, Immunologic / Q000379:methods*; D006801:Humans; D060046:Maintenance Chemotherapy; D009298:Nasal Polyps / Q000276:immunology / Q000601:surgery* / Q000628:therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin
keywords: aspirin exacerbated respiratory disease; desensitization