title: Sinusitis in patients undergoing allogeneic bone marrow transplantation - a review.
abstract: BACKGROUND
  Sinusitis is a common morbidity in general population, however little is known about its occurrence in severely immunocompromised patients undergoing allogeneic hematopoietic stem cell transplantation.
  
  
  OBJECTIVE
  The aim of the study was to analyze the literature concerning sinusitis in patients undergoing allogeneic bone marrow transplantation.
  
  
  METHODS
  An electronic database search was performed with the objective of identifying all original trials examining sinusitis in allogeneic hematopoietic stem cell transplant recipients. The search was limited to English-language publications.
  
  
  RESULTS
  Twenty five studies, published between 1985 and 2015 were identified, none of them being a randomized clinical trial. They reported on 31-955 patients, discussing different issues i.e. value of pretransplant sinonasal evaluation and its impact on post-transplant morbidity and mortality, treatment, risk factors analysis.
  
  
  CONCLUSIONS
  Results from analyzed studies yielded inconsistent results. Nevertheless, some recommendations for good practice could be made. First, it seems advisable to screen all patients undergoing allogeneic hematopoietic stem cell transplantation with Computed Tomography (CT) prior to procedure. Second, patients with symptoms of sinusitis should be treated before hematopoietic stem cell transplantation (HSCT), preferably with conservative medical approach. Third, patients who have undergone hematopoietic stem cell transplantation should be monitored closely for sinusitis, especially in the early period after transplantation.
authors.affiliation: The Medical University of Warsaw, Oncology and Internal Diseases, Department of Hematology, Warsaw, Poland.
authors.forename: Joanna Ewa
authors.initials: JE
authors.lastname: Drozd-Sokolowska
authors.affiliation: The Medical University of Warsaw, Department of Otorhinolaryngology, Warsaw, Poland. Electronic address: jacsokolowski@gmail.com.
authors.forename: Jacek
authors.initials: J
authors.lastname: Sokolowski
authors.affiliation: The Medical University of Warsaw, Oncology and Internal Diseases, Department of Hematology, Warsaw, Poland.
authors.forename: Wieslaw
authors.initials: W
authors.lastname: Wiktor-Jedrzejczak
authors.affiliation: The Medical University of Warsaw, Department of Otorhinolaryngology, Warsaw, Poland.
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Niemczyk
mesh_terms: D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D012307:Risk Factors; D012852:Sinusitis / Q000209:etiology*
keywords: Bone marrow transplantation; Hematopoietic stem cell transplantation; Sinusite; Sinusitis; Sinusitis treatment; Transplante de célula tronco hematopoiética; Transplante de medula óssea; Tratamento da sinusite