title: The Acute Effect of the Antioxidant Drug U-74389G on Red Blood Cell Distribution Width Levels During Hypoxia Reoxygenation Injury in Rats.
abstract: The AIM of this experimental study was to evaluate the effect of the antioxidant drug "U-74389G" in a rat model of hypoxia reoxygenation (HR) using the previously established protocol. Effects of treatment were evaluated by mean red blood cell distribution width (RDW) levels.
  
  
  
  40 rats of a mean weight of 231.875 g were employed in the study. RDW levels were determined at 60 min (groups A and C) and at 120 min (groups B and D) after starting the reoxygenation. Groups A and B received no drugs, whereas rats from groups C and D were administered with U-74389G.
  
  
  
  demonstrated that U-74389G administration significantly decreased the RDW levels by 4.96% + 2.27% (p = 0.0175). Reoxygenation time non-significantly decreased the RDW levels by 0.27% + 2.41% (p = 0.8889). Together, U-74389G administration and reoxygenation time non-significantly decreased the RDW levels by 2.54% + 1.39% (p = 0.0679).
  
  
  
  U-74389G administration particulary in concert without reperfusion declines the RDW levels even within the short - time context of 1.5 hours reperfusion.
authors.affiliation: Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania, Greece
authors.forename: Constantinos
authors.initials: C
authors.lastname: Tsompos
authors.affiliation: Department of Obstetrics & Gynecology, Aretaieion Hospital
authors.forename: Constantinos
authors.initials: C
authors.lastname: Panoulis
authors.affiliation: Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Toutouzas
authors.affiliation: Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
authors.forename: George
authors.initials: G
authors.lastname: Zografos
authors.affiliation: Exprerimental Research Center ELPEN Pharmaceuticals, Greece
authors.forename: Apostolos
authors.initials: A
authors.lastname: Papalois
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004909:Erythrocyte Indices / Q000187:drug effects*; D005260:Female; D000860:Hypoxia / Q000097:blood*; D010100:Oxygen / Q000097:blood / Q000378:metabolism; D011281:Pregnatrienes / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000097:blood*
chemical_list: D000975:Antioxidants; D011281:Pregnatrienes; C074965:U 74389F; D010100:Oxygen