title: Enantioselective Synthesis of Cyclobutylboronates via a Copper-Catalyzed Desymmetrization Approach.
abstract: The first catalytic enantioselective synthesis of cyclobutylboronates, by using a chiral copper(I) complex, is reported. A broad variety of cyclobutanes have been prepared with consistently high levels of diastereo- and enantiocontrol. Moreover, this method constitutes the first report of an enantioselective desymmetrization of meso-cyclobutenes to prepare chiral cyclobutanes.
authors.affiliation: Universidad Autonoma de Madrid, Madrid, Spain.
authors.forename: Manuel
authors.identifier: 0000-0001-7355-2795
authors.initials: M
authors.lastname: Guisán-Ceinos
authors.affiliation: Universidad Autonoma de Madrid, Madrid, Spain.
authors.forename: Alejandro
authors.identifier: 0000-0002-0097-2585
authors.initials: A
authors.lastname: Parra
authors.affiliation: Universidad Autonoma de Madrid, Madrid, Spain.
authors.forename: Víctor
authors.identifier: 0000-0002-7271-3574
authors.initials: V
authors.lastname: Martín-Heras
authors.affiliation: Universidad Autonoma de Madrid, Madrid, Spain. mariola.tortosa@uam.es.
authors.forename: Mariola
authors.identifier: 0000-0002-5107-0549
authors.initials: M
authors.lastname: Tortosa
keywords: asymmetric catalysis; boron; copper; cyclobutanes; cyclobutenes