title: Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation.
abstract: Here we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three separate cohorts totalling 279 lesions. We have identified a set of eight markers that distinguish naevi from melanoma. None of markers or parameters assessed differentiated benign from dysplastic naevi. Indeed, the naevi clustered tightly in terms of their immunostaining patterns whereas primary melanomas showed more diverse staining patterns. A small subset of histopathologically benign lesions had elevated levels of multiple markers associated with melanoma, suggesting that these represent naevi with an increased potential for transformation to melanoma.
authors.affiliation: The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Qld, Australia.
authors.forename: Carly
authors.initials: C
authors.lastname: Fox
authors.affiliation: IQ Pathology, Brisbane, Qld, Australia.
authors.forename: Duncan
authors.initials: D
authors.lastname: Lambie
authors.affiliation: Melanoma Institute Australia, Sydney, NSW, Australia.
authors.forename: James S
authors.initials: JS
authors.lastname: Wilmott
authors.affiliation: The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Qld, Australia.
authors.forename: Alex
authors.initials: A
authors.lastname: Pinder
authors.affiliation: The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Qld, Australia.
authors.forename: Sandra
authors.initials: S
authors.lastname: Pavey
authors.affiliation: The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Qld, Australia.
authors.forename: Kim-Anh
authors.initials: KA
authors.lastname: Lê Cao
authors.affiliation: Department of Pathology, Ege University, Izmir, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Akalin
authors.affiliation: Department of Dermatology, Ege University, Izmir, Turkey.
authors.forename: Isil Kilinc
authors.initials: IK
authors.lastname: Karaarslan
authors.affiliation: Department of Dermatology, Ege University, Izmir, Turkey.
authors.forename: Fezal
authors.initials: F
authors.lastname: Ozdemir
authors.affiliation: Melanoma Institute Australia, Sydney, NSW, Australia.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Scolyer
authors.affiliation: Dermatology Research Centre, Translational Research Institute, The University of Queensland School of Medicine, Brisbane, Qld, Australia.
authors.forename: Miko
authors.initials: M
authors.lastname: Yamada
authors.affiliation: Dermatology Research Centre, Translational Research Institute, The University of Queensland School of Medicine, Brisbane, Qld, Australia.
authors.forename: H Peter
authors.initials: HP
authors.lastname: Soyer
authors.affiliation: Dermatology Research Centre, Translational Research Institute, The University of Queensland School of Medicine, Brisbane, Qld, Australia.
authors.forename: Helmut
authors.initials: H
authors.lastname: Schaider
authors.affiliation: The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Qld, Australia.
authors.forename: Brian
authors.initials: B
authors.lastname: Gabrielli
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008545:Melanoma / Q000378:metabolism / Q000473:pathology*; D009508:Nevus, Pigmented / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D046888:Tissue Array Analysis
chemical_list: D015415:Biomarkers
keywords: markers; naevi; transformation