title: Cutaneous manifestations of lung cancer.
abstract: Skin findings can serve as a clue to internal disease. In this article, cutaneous manifestations of underlying lung malignancy are reviewed. Paraneoplastic dermatoses are rare, but when recognized early, can lead to early diagnosis of an underlying neoplasm. Malignancy-associated dermatoses comprise a broad group of hyperproliferative and inflammatory disorders, disorders caused by tumor production of hormonal or metabolic factors, autoimmune connective tissue diseases, among others. In this review, paraneoplastic syndromes associated with lung malignancy are discussed, including ectopic ACTH syndrome, bronchial carcinoid variant syndrome, secondary hypertrophic osteoarthropathy/digital clubbing, erythema gyratum repens, malignant acanthosis nigricans, sign of Leser-Trélat, tripe palms, hypertrichosis lanuginosa, acrokeratosis paraneoplastica, and dermatomyositis.
authors.affiliation: University of Louisville, Division of Dermatology, Louisville, KY. Electronic address: ceowen01@louisville.edu.
authors.forename: Cindy England
authors.initials: CE
authors.lastname: Owen
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000473:pathology; D000052:Acanthosis Nigricans / Q000209:etiology / Q000473:pathology; D003882:Dermatomyositis / Q000209:etiology / Q000473:pathology; D004890:Erythema / Q000209:etiology / Q000473:pathology; D006801:Humans; D006983:Hypertrichosis / Q000209:etiology / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000209:etiology / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000473:pathology; D013479:Superior Vena Cava Syndrome / Q000209:etiology / Q000473:pathology
keywords: Acrokeratosis paraneoplastica; Bronchial carcinoid variant syndrome; Ectopic ACTH syndrome; Hypertrophic osteoarthropathy; Lung cancer