title: Claes Hellerström and Cartesian diver microrespirometry.
abstract: Cartesian diver microrespirometry was introduced by Claes Hellerström at the Department of Histology/Medical Cell Biology at Uppsala University, Sweden, to determine rates of oxygen consumption in islets of Langerhans. The theory behind this method is touched upon and the main findings described. Glucose-stimulated beta cell respiration significantly contributes to increased ATP generation, which is a prerequisite for stimulated insulin secretion and synthesis. This has had major implications for understanding the beta cell stimulus-secretion coupling.
authors.affiliation: a Department of Medical Cell Biology , Uppsala University , Uppsala , Sweden.
authors.forename: Michael
authors.initials: M
authors.lastname: Welsh
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D000818:Animals; D001695:Biology / Q000266:history*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis; D049673:History, 20th Century; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000378:metabolism; D007515:Islets of Langerhans / Q000473:pathology / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption; D013548:Sweden; D014495:Universities
chemical_list: D007328:Insulin; D000255:Adenosine Triphosphate; D005947:Glucose; D010100:Oxygen
keywords: Cartesian diver; glucose; insulin secretion; islets of Langerhans; respiration