title: A Novel Collagen-Gelatin Scaffold for the Treatment of Deep Dermal Wounds-An Evaluation in a Minipig Model.
abstract: BACKGROUND
  Today, autologous skin transplantation is frequently used for full-thickness skin defects. There is still a high demand for new wound-healing products to replace autologous skin transplantation.
  
  
  OBJECTIVE
  In this context, the effect of a new collagen-gelatin scaffold on full-thickness skin defects was evaluated.
  
  
  METHODS
  Four full-thickness skin defects were created surgically on the dorsum of 6 Göttingen minipigs. Three wounds were randomly treated with a novel collagen-gelatin scaffold in different thicknesses, whereas the fourth wound was left untreated and served as a control wound. During the experimental period of 21 days, a close-up photographic documentation was performed. Afterwards, the areas of the initial wounds were excised and examined histologically.
  
  
  RESULTS
  The systematic evaluation of 24 wounds showed that treatment with the new collagen-gelatin scaffold led to an accelerated wound repair of 1.1 days. Compared to control wounds, it also demonstrated improved skin quality in regard to epidermal thickness.
  
  
  CONCLUSIONS
  The new collagen-gelatin scaffold supports and accelerates dermal wound repair compared to untreated control wounds. Nevertheless, wound treatment with the scaffold was only performed on the first day. In further studies, the impact of multiple scaffold applications on full-thickness skin defects should be investigated.
authors.affiliation: *Department of Plastic, Reconstructive, Hand and Burn Surgery, BG-Trauma Center, Eberhard Karls University Tuebingen, Germany; †Department of Plastic and Hand Surgery, Reconstructive and Aesthetic Surgery, HELIOS Klinikum Wuppertal GmbH, University Hospital Witten/Herdecke, Germany.
authors.forename: Manuel
authors.initials: M
authors.lastname: Held
authors.forename: Afshin
authors.initials: A
authors.lastname: Rahmanian-Schwarz
authors.forename: Jennifer
authors.initials: J
authors.lastname: Schiefer
authors.forename: Rebekka
authors.initials: R
authors.lastname: Rath
authors.forename: Jan-Ole
authors.initials: JO
authors.lastname: Werner
authors.forename: Shahab
authors.initials: S
authors.lastname: Rahmanian
authors.forename: Hans-Eberhard
authors.initials: HE
authors.lastname: Schaller
authors.forename: Wiebke
authors.initials: W
authors.lastname: Petersen
mesh_terms: D000818:Animals; D001458:Bandages; D003094:Collagen / Q000494:pharmacology*; D004195:Disease Models, Animal; D005780:Gelatin / Q000494:pharmacology*; D013552:Swine; D013556:Swine, Miniature; D054457:Tissue Scaffolds; D014945:Wound Healing / Q000502:physiology*
chemical_list: D005780:Gelatin; D003094:Collagen