title: Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation.
abstract: Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Although SOS/VOD progressively resolves within a few weeks in most patients, the most severe forms result in multi-organ dysfunction and are associated with a high mortality rate (>80%). Therefore, careful attention must be paid to allow an early detection of SOS/VOD, particularly as drugs have now proven to be effective and licensed for its treatment. Unfortunately, current criteria lack sensitivity and specificity, making early identification and severity assessment of SOS/VOD difficult. The aim of this work is to propose a new definition for diagnosis, and a severity-grading system for SOS/VOD in adult patients, on behalf of the European Society for Blood and Marrow Transplantation.
authors.affiliation: Hematology Department, Hôpital Saint Antoine, and Université Pierre & Marie Curie, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Mohty
authors.affiliation: Hematology Department, Hôpital Saint Antoine, and Université Pierre & Marie Curie, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Malard
authors.affiliation: Instituto Portugues de Oncologia, Lisbon, Portugal.
authors.forename: M
authors.initials: M
authors.lastname: Abecassis
authors.affiliation: Department of Haematology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: E
authors.initials: E
authors.lastname: Aerts
authors.affiliation: King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, Department of Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
authors.forename: A S
authors.initials: AS
authors.lastname: Alaskar
authors.affiliation: King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors.forename: M
authors.initials: M
authors.lastname: Aljurf
authors.affiliation: Sisli Florence Nightingale Hospital, HSCT Unit, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Arat
authors.affiliation: Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Bader
authors.affiliation: Department of Hematology, University of Liege, Liege, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Baron
authors.affiliation: Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
authors.forename: A
authors.initials: A
authors.lastname: Bazarbachi
authors.affiliation: Blood and Marrow Transplantation Program, Hematology Department, Institut Paoli-Calmettes, Marseille, France.
authors.forename: D
authors.initials: D
authors.lastname: Blaise
authors.affiliation: Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ciceri
authors.affiliation: Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Corbacioglu
authors.affiliation: Department of Hematology and Immunology, Hospital Robert Debre, Paris 7-Paris Diderot University, Paris, France.
authors.forename: J-H
authors.initials: JH
authors.lastname: Dalle
authors.affiliation: Department of Clinical Haematology, Central Manchester Foundation Trust, Manchester, UK.
authors.forename: F
authors.initials: F
authors.lastname: Dignan
authors.affiliation: HSCT division, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
authors.affiliation: Hematology Department, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France.
authors.forename: A
authors.initials: A
authors.lastname: Huynh
authors.affiliation: Department of Hematology and Stem Cell Transplantation, St Istvan and St Laszlo Hospital, Budapest 3 Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: T
authors.initials: T
authors.lastname: Masszi
authors.affiliation: Hematology Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon EST, Pierre Bénite, France.
authors.forename: M
authors.initials: M
authors.lastname: Michallet
authors.affiliation: Hematology and Bone Marrow Transplantation, Chaim Sheba Medical center, Tel-Hashomer, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Nagler
authors.affiliation: National Stem Cell Transplant Unit (Adults), Department of Haematology, St James's Hospital and Academic Department of Haematology, Trinity College Dublin, Dublin, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: NiChonghaile
authors.affiliation: Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Okamoto
authors.affiliation: Department of Haematology, King's College Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Pagliuca
authors.affiliation: Department of Pediatrics, St Anna Kinderspital, Vienna, Austria.
authors.forename: C
authors.identifier: http://orcid.org/0000-0003-0369-8515
authors.initials: C
authors.lastname: Peters
authors.affiliation: LDS Hospital, Salt Lake City, UT, USA.
authors.forename: F B
authors.initials: FB
authors.lastname: Petersen
authors.affiliation: Division of Hematologic Malignancy, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: P G
authors.initials: PG
authors.lastname: Richardson
authors.affiliation: Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Ruutu
authors.affiliation: Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, Tennessee.
authors.forename: B N
authors.initials: BN
authors.lastname: Savani
authors.affiliation: Section of Haematology and Coagulation, Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Wallhult
authors.affiliation: CHU de Lille, LIRIC INSERM U995, université de Lille2, France.
authors.forename: I
authors.initials: I
authors.lastname: Yakoub-Agha
authors.affiliation: Department of Hematology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
authors.forename: R F
authors.initials: RF
authors.lastname: Duarte
authors.affiliation: Josep Carreras Foundation & Leukemia Research Institute, Hematology Department, Hospital Clínic, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Carreras
mesh_terms: D000328:Adult; D015415:Biomarkers; D042241:Early Diagnosis; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006504:Hepatic Veno-Occlusive Disease / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006801:Humans; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers