title: The impact of chronic use of prostaglandin analogues on the biomechanical properties of the cornea in patients with primary open-angle glaucoma.
abstract: To determine the influence of prostaglandin analogues (PGAs) on corneal biomechanical properties in patients undergoing chronic treatment for primary open-angle glaucoma (POAG).
  
  
  
  Prospective, interventional case-control study. 70 eyes from 35 patients with POAG on chronic PGA therapy were recruited. One eye per patient underwent PGA cessation for 6 weeks while the contralateral eye continued to receive the treatment. Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOP) (IOPcc), central corneal thickness (CCT) and Goldmann tonometry (Haag-Streit AG, Koeniz, Switzerland) IOP (IOPGAT) were measured at baseline (visit 1), 6 weeks after PGA cessation (visit 2) and 6 weeks after PGAs reinitiation (visit 3) and were analysed using a linear mixed-effect model. The discrepancy between IOPcc and IOPGATwas defined as IOP bias (IOPcc-IOPGAT).
  
  
  
  Baseline characteristics were comparable between the two groups. In the study eyes, significant increases (p<0.0001) were detected at visit 2 in CH (9.0±1.8 vs 10.3±1.7 mm Hg), CRF (10.5±2.1 vs 11.7±2.1 mm Hg), CCT (541.8±43.2 vs 551.9±41.9 μm) and IOPGAT(15.4±3.0 vs 18.4±3.8 mm Hg). IOP bias in this group was significantly lowered at visit 2 (p<0.0001). These effects were reversed at visit 3. The control eyes did not demonstrate any significant changes over the study period.
  
  
  
  Topical PGAs induce reversible reduction in CH, CRF and CCT in patients with POAG. These changes contribute to underestimation of the IOP measured by Goldmann applanation tonometry and warrant caution when assessing response to treatment.
  
  
  
  NCT02388360, Results.
authors.affiliation: Department of Ophthalmology, University of Montreal, Montreal, Quebec, Canada.|Montreal Glaucoma Institute, Montreal, Quebec, Canada.
authors.forename: Roman
authors.initials: R
authors.lastname: Meda
authors.affiliation: Department of Ophthalmology, University of Montreal, Montreal, Quebec, Canada.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Paoloni
authors.affiliation: Department of Ophthalmology, University of Montreal, Montreal, Quebec, Canada.|Montreal Glaucoma Institute, Montreal, Quebec, Canada.|Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Harasymowycz
authors.affiliation: Department of Ophthalmology, University of Montreal, Montreal, Quebec, Canada.|Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec, Canada.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Brunette
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000009:adverse effects*; D001696:Biomechanical Phenomena; D016022:Case-Control Studies; D003315:Cornea / Q000187:drug effects* / Q000503:physiopathology; D063171:Corneal Pachymetry; D004548:Elasticity; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011465:Prostaglandins, Synthetic / Q000009:adverse effects*; D014065:Tonometry, Ocular
chemical_list: D000959:Antihypertensive Agents; D011465:Prostaglandins, Synthetic
keywords: Anterior chamber; Cornea; Glaucoma; Intraocular pressure