title: Tuning the reactivity of Sp1 zinc fingers with platinum complexes.
abstract: cis-DDP presents reactivity towards the transcription factor Sp1-F3, as opposed to previous observations for Sp1-F2. Replacing the ammine ligands with the chelating ethylenediamine increases the reactivity giving a unique dinuclear {Pt(en)}2-bis(cysteine)-bridged product, confirmed by study of the binding sequence ACPECP.
authors.affiliation: Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284-2006, USA. npfarrell@vcu.edu.
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Du
authors.forename: Raphael E F
authors.initials: RE
authors.lastname: de Paiva
authors.forename: Yun
authors.initials: Y
authors.lastname: Qu
authors.forename: Nicholas
authors.initials: N
authors.lastname: Farrell
mesh_terms: D000595:Amino Acid Sequence; D056831:Coordination Complexes / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010984:Platinum / Q000737:chemistry*; D011485:Protein Binding; D016329:Sp1 Transcription Factor / Q000737:chemistry* / Q000378:metabolism; D016335:Zinc Fingers
chemical_list: D056831:Coordination Complexes; D016329:Sp1 Transcription Factor; C108209:SP1 protein, human; D010984:Platinum