title: Magnetic hydrogel beads based on PVA/sodium alginate/laponite RD and studying their BSA adsorption.
abstract: In this study double physically crosslinked magnetic hydrogel beads were developed by a simple method including solution mixing of sodium alginate and poly(vinyl alcohol) (PVA) containing magnetic laponite RD (Rapid Dispersion). Sodium alginate and PVA were physically crosslinked by Ca(2+) and freezing-thawing cycles, respectively. Magnetic laponite RD nanoparticles were incorporated into the system to create magnetic response and strengthen the hydrogels. All hybrids double physically crosslinked hydrogel beads were stable under different pH values without any disintegration. Furthermore, adsorption of bovine serum albumin (BSA) on the hydrogel beads was investigated on the subject of pH, ion strength, initial BSA concentration, and temperature. Nanocomposite beads exhibited maximum adsorption capacity for BSA at pH=4.5. The experimental adsorption isotherm data were well followed Langmuir model and based on this model the maximum adsorption capacity was obtained 127.3mgg(-1) at 308K. Thermodynamic parameters revealed spontaneous and monolayer adsorption of BSA on magnetic nanocomposites beads.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Maragheh, P.O. Box 55181-83111, Maragheh, Iran. Electronic address: grmnia@maragheh.ac.ir.
authors.forename: Gholam Reza
authors.initials: GR
authors.lastname: Mahdavinia
authors.affiliation: Department of Materials Engineering, Faculty of Engineering, University of Maragheh, P.O. Box 55181-83111, Maragheh, Iran.
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Mousanezhad
authors.affiliation: Department of Chemistry, Faculty of Science, University of Maragheh, P.O. Box 55181-83111, Maragheh, Iran.
authors.forename: Hamed
authors.initials: H
authors.lastname: Hosseinzadeh
authors.affiliation: Department of Microbiology, Faculty of Science, University of Maragheh, P.O. Box 55181-83111, Maragheh, Iran.
authors.forename: Farshad
authors.initials: F
authors.lastname: Darvishi
authors.affiliation: Department of Chemical Engineering, University of Maragheh, 55181-83111, Maragheh, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Sabzi
mesh_terms: D000327:Adsorption; D000464:Alginates / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008280:Magnetics; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D017640:Silicates / Q000737:chemistry
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D020100:Hydrogels; D017640:Silicates; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D012710:Serum Albumin, Bovine; D020723:Glucuronic Acid; D011142:Polyvinyl Alcohol; C524813:laponite
keywords: BSA Adsorption; Laponite RD; Magnetic beads; Nanocomposite; Poly(vinyl alcohol); Sodium alginate