title: Effects of Tadalafil 5 mg Dosed Once Daily in Men with Premature Ejaculation.
abstract: OBJECTIVE
  In this study, we evaluated the effect of 5 mg tadalafil once daily in men with premature ejaculation (PE).
  
  
  METHODS
  Thirty married men with lifelong PE and 30 healthy men as control group were included in this study. All the patients received 5 mg tadalafil once a day for a month. The international index of erectile function questionnaire and intravaginal ejaculatory latency times (IELTs) and PE profile were recorded before and after treatment. Plasma samples were collected before and after treatment.
  
  
  RESULTS
  The mean baseline IELTs was 40.8 ± 8.1 s in the PE group and 196.5 ± 26.2 s in the control group. After treatment in the PE group, the mean IELTs values showed a statistically significant improvement from the baseline values. At the end of 4 weeks, in the PE group, the mean IELT values showed a statistically significant improvement from the baseline values. Baseline serum nitric oxide (NO) levels were 27.3 ± 1.7 in the PE group and in the 31.1 ± 1.4 healthy control groups. After treatment, NO levels were increased from baseline.
  
  
  CONCLUSIONS
  We consider that 5 mg tadalafil once daily is safety and effective for the treatment of PE.
authors.affiliation: Department of Urology, Derince Training and Research Hospital, Kocaeli, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Ozcan
authors.forename: Emre Can
authors.initials: EC
authors.lastname: Polat
authors.forename: Efe
authors.initials: E
authors.lastname: Onen
authors.forename: Ramazan
authors.initials: R
authors.lastname: Kocaaslan
authors.forename: Alper
authors.initials: A
authors.lastname: Otunctemur
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cekmen
authors.forename: Ceyla
authors.initials: C
authors.lastname: Eraldemir
authors.forename: Emin
authors.initials: E
authors.lastname: Ozbek
mesh_terms: D000328:Adult; D002243:Carbolines; D016022:Case-Control Studies; D004334:Drug Administration Schedule; D004542:Ejaculation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D061686:Premature Ejaculation / Q000188:drug therapy*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D000068581:Tadalafil / Q000008:administration & dosage*; D016896:Treatment Outcome; D064804:Urological Agents / Q000008:administration & dosage*
chemical_list: D002243:Carbolines; D064804:Urological Agents; D009569:Nitric Oxide; D000068581:Tadalafil