title: Approaches for the prevention of graft-versus-host disease following hematopoietic cell transplantation.
abstract: Allogeneic hematopoietic cell transplantation (HCT) is an important therapeutic option for malignant and non-malignant diseases, but the more widespread application of the therapy remains limited by the occurrence of graft versus host disease (GVHD). GVHD results from immune-mediated injury by donor immune cells against tissues in the HCT recipient, and can be characterized as acute or chronic depending on the time of onset and site of organ involvement. The majority of efforts have focused on GVHD prevention. Calcineurin inhibitors are the most widely used agents and are included in almost all regimens. Despite current prophylaxis strategies, 40-70% of patients remain at risk for developing GVHD. Herein, we review standard and emerging therapies used in GVHD management.
authors.affiliation: Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, United States; Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, United States.
authors.forename: Erin
authors.initials: E
authors.lastname: Gatza
authors.affiliation: Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, United States; Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, United States.
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Choi
keywords: GVHD; acute; calcineurin inhibitors; chronic; hematopoietic stem cell transplantation; prophylaxis; treatment