title: [XIGDUO - fixed combination of the active ingredients dapagliflozin and metformin].
abstract: Fixed dose combination of two different drugs in the same or related indications are successfully used in various medical fields including diabetology. This article deals with the combination therapy comprising metformin and dapagliflozin in a single preparation, molecules affecting different pathophysiological mechanisms of type 2 diabetes, particularly insulin resistance and increased glucose reabsorption in the kidney. Most patients with type 2 diabetes does not achieve target glycemic control when treated with single antidiabetics and need for proper control of diabetes combination of several different drugs. Using the fixed combination leads to improved patients adherence and utilization of the full therapeutic potential of selected drugs.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Edelsberger
mesh_terms: D001559:Benzhydryl Compounds / Q000008:administration & dosage*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004338:Drug Combinations; D005960:Glucosides / Q000008:administration & dosage*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008687:Metformin / Q000008:administration & dosage*; D051247:Sodium-Glucose Transport Proteins / Q000037:antagonists & inhibitors
chemical_list: D001559:Benzhydryl Compounds; D004338:Drug Combinations; D005960:Glucosides; D007004:Hypoglycemic Agents; D051247:Sodium-Glucose Transport Proteins; C529054:dapagliflozin; D008687:Metformin