title: Transfer Function Analysis of Dynamic Blood Flow Control in the Rat Kidney.
abstract: Renal blood flow is regulated by the myogenic response (MR) and tubuloglomerular feedback (TGF). Both mechanisms function to buffer not only steady pressure perturbations but also transient ones. In this study, we develop two models of renal autoregulation-a comprehensive model and a simplified model-and use them to analyze the individual contributions of MR and TGF in buffering transient pressure perturbations. Both models represent a single nephron of a rat kidney together with the associated vasculature. The comprehensive model includes detailed representation of the vascular properties and cellular processes. In contrast, the simplified model represents a minimal set of key processes. To assess the degree to which fluctuations in renal perfusion pressure at different frequencies are attenuated, we derive a transfer function for each model. The transfer functions of both models predict resonance at 45 and 180 mHz, which are associated with TGF and MR, respectively, effective autoregulation below [Formula: see text]100 mHz, and amplification of pressure perturbations above [Formula: see text]200 mHz. The predictions are in good agreement with experimental findings.
authors.affiliation: National Institute for Mathematical and Biological Synthesis, University of Tennessee, Knoxville, TN, USA. sgouralis@nimbios.org.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Sgouralis
authors.affiliation: Department of Mathematics, University of Tennessee, Knoxville, TN, USA.
authors.forename: Vasileios
authors.initials: V
authors.lastname: Maroulas
authors.affiliation: Department of Mathematics, Duke University, Durham, NC, USA.
authors.forename: Anita T
authors.initials: AT
authors.lastname: Layton
mesh_terms: D000818:Animals; D006439:Hemodynamics / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D055641:Mathematical Concepts; D008564:Membrane Potentials; D008954:Models, Biological; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D051381:Rats; D012079:Renal Circulation / Q000502:physiology*; D014655:Vascular Resistance
keywords: Autoregulation; Complex system; Dynamic control; Hemodynamics; Kidney; System identification; Transfer function