title: Synchronous pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma arising in the context of intraductal papillary neoplasms.
abstract: Field cancerization theory provides rationale for the development of multiple pancreatic ductal and biliary lesions in a single patient through the development and accumulation of multiple genetic changes. Genetic alterations result in the development of precursor lesions including intraductal papillary mucinous neoplasms of the pancreas (IPMN), intraductal papillary neoplasm of the bile duct (IPN-B), and their malignant counterparts, pancreatic adenocarcinoma and cholangiocarcinoma. Although IPMN are frequently encountered, IPN-B are uncommon and the synchronous occurrence of both lesions is rare. We present a case of synchronous pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma with histopathologic evidence of underlying precursor lesions, IPMN-P and IPN-B.
authors.affiliation: Department of Radiology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029.
authors.forename: Anmol
authors.initials: A
authors.lastname: Bansal
authors.affiliation: The Lillian and Henry Stratton-Hans Popper Department of Pathology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029.
authors.forename: Swan N
authors.initials: SN
authors.lastname: Thung
authors.affiliation: The Lillian and Henry Stratton-Hans Popper Department of Pathology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029.
authors.forename: Hongfa
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Surgery, RMTI Liver Surgery Program, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029.
authors.forename: Myron
authors.initials: M
authors.lastname: Schwartz
authors.affiliation: Department of Radiology, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029. Electronic address: sara.lewis@mountsinai.org.
authors.forename: Sara
authors.initials: S
authors.lastname: Lewis
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D000368:Aged; D001650:Bile Duct Neoplasms / Q000175:diagnosis*; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis*; D018281:Cholangiocarcinoma / Q000175:diagnosis*; D003937:Diagnosis, Differential; D019160:Endosonography / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*
keywords: Cholangiocarcinoma; Intraductal papillary mucinous neoplasm of pancreas; Intraductal papillary neoplasm of the bile duct; Pancreatic adenocarcinoma; Synchronous