title: HPV Update: Vaccination, Screening, and Associated Disease.
abstract: Human papillomavirus (HPV) infection is the causative agent in cervical cancer, and is associated with numerous other genital cancers, including vulvar, vaginal, and anal cancer. Primary prevention with HPV vaccination is safe and efficacious, and a recently approved HPV vaccine will provide even more extensive protection against several oncogenic HPV strains. Screening strategies for HPV are rapidly evolving, reflecting the essential role that HPV infection plays in cervical cancer. This article highlights new evidence regarding the efficacy of the recently approved 9-valent HPV (9vHPV) vaccine and the use of primary high-risk HPV testing in cervical cancer screening. We consider the utility of urinary HPV testing in routine clinical practice and review current guidelines regarding anal HPV screening.
authors.affiliation: Department of Medicine, Case Western Reserve University School of Medicine and Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH, 44106, USA. megan.mcnamara@va.gov.
authors.forename: Megan
authors.initials: M
authors.lastname: McNamara
authors.affiliation: Department of Medicine and Primary Care Women's Health, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Pelin
authors.initials: P
authors.lastname: Batur
authors.affiliation: Department of Medicine and Women's Health Clinical Research Center, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Judith M E
authors.initials: JME
authors.lastname: Walsh
authors.affiliation: Department of Medicine, University of Washington School of Medicine and VA Puget Sound Health Care System, Seattle, WA, USA.
authors.forename: Kay M
authors.initials: KM
authors.lastname: Johnson
mesh_terms: D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000187:drug effects / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D053918:Papillomavirus Vaccines / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D014611:Vaccination / Q000379:methods*
chemical_list: D053918:Papillomavirus Vaccines
keywords: HPV; cervical cancer; prevention; screening; vaccination