title: Die another day: Molecular mechanisms of effector-triggered immunity elicited by type III secreted effector proteins.
abstract: Bacterial pathogens inject type III secreted effector (T3SE) proteins into their hosts where they display dual roles depending on the host genotype. T3SEs promote bacterial virulence in susceptible hosts, and elicit immunity in resistant hosts. T3SEs are typically recognized when they modify a host target that is associated with a NOD-like receptor protein. We focus on the molecular mechanisms of T3SE recognition in plants. Plants guard multiple nodes of the immune signaling pathway, from recognition at the cell surface by receptor-like kinases to nuclear signaling. Some nodes are bacterial virulence targets, while other nodes are decoys that resemble true virulence targets.
authors.affiliation: Department of Plant and Microbial Biology, University of California, Berkeley, 800 Buchanan St., Albany, CA 94710, USA. Electronic address: karl.schreiber@berkeley.edu.
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Schreiber
authors.affiliation: Department of Plant and Microbial Biology, University of California, Berkeley, 800 Buchanan St., Albany, CA 94710, USA. Electronic address: mael.baudin@berkeley.edu.
authors.forename: Maël
authors.initials: M
authors.lastname: Baudin
authors.affiliation: Department of Plant and Microbial Biology, University of California, Berkeley, 800 Buchanan St., Albany, CA 94710, USA. Electronic address: jana.a.hassan@berkeley.edu.
authors.forename: Jana A
authors.initials: JA
authors.lastname: Hassan
authors.affiliation: Department of Plant and Microbial Biology, University of California, Berkeley, 800 Buchanan St., Albany, CA 94710, USA; Plant Gene Expression Center, United States Department of Agriculture, Albany, CA 94710, USA. Electronic address: jdlewis@berkeley.edu.
authors.forename: Jennifer D
authors.initials: JD
authors.lastname: Lewis
mesh_terms: D058947:Bacterial Secretion Systems / Q000378:metabolism*; D001665:Binding Sites; D060467:Disease Resistance; D057865:Plant Immunity; D011401:Promoter Regions, Genetic / Q000235:genetics; D014774:Virulence
chemical_list: D058947:Bacterial Secretion Systems
keywords: Effector-triggered-immunity; NOD-like receptor; Plant pathogenic bacteria; Type III secreted effector protein