title: Development of a floating drug delivery system with superior buoyancy in gastric fluid using hot-melt extrusion coupled with pressurized CO₂.
abstract: The present study aimed to develop a continuous single-step manufacturing platform to prepare a porous, low-density, and floating multi-particulate system (mini-tablet, 4 mm size). This process involves injecting inert, non-toxic pressurized CO₂gas (P-CO₂) in zone 4 of a 16-mm hot-melt extruder (HME) to continuously generate pores throughout the carrier matrix. Unlike conventional methods for preparing floating drug delivery systems, additional chemical excipients and additives are not needed in this approach to create minute openings on the surface of the matrices. The buoyancy efficiency of the prepared floating system (injection of P-CO₂) in terms of lag time (0 s) significantly improved (P < 0.05), compared to the formulation prepared by adding the excipient sodium bicarbonate (lag time 120 s). The main advantages of this novel manufacturing technique include: (i) no additional chemical excipients need to be incorporated in the formulation, (ii) few manufacturing steps are required, (iii) high buoyancy efficiency is attained, and (iv) the extrudate is free of toxic solvent residues. Floating mini-tablets containing acetaminophen (APAP) as a model drug within the matrix-forming carrier (Eudragit® RL PO) have been successfully processed via this combined technique (P-CO₂/HME). Desired controlled release profile of APAP from the polymer Eudragit® RL PO is attained in the optimized formulation, which remains buoyant on the surface of gastric fluids prior to gastric emptying time (average each 4 h).
authors.forename: B K
authors.initials: BK
authors.lastname: Almutairy
authors.forename: A S
authors.initials: AS
authors.lastname: Alshetaili
authors.forename: E A
authors.initials: EA
authors.lastname: Ashour
authors.forename: H
authors.initials: H
authors.lastname: Patil
authors.forename: R V
authors.initials: RV
authors.lastname: Tiwari
authors.forename: S M
authors.initials: SM
authors.lastname: Alshehri
authors.forename: M A
authors.initials: MA
authors.lastname: Repka
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000737:chemistry; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000737:chemistry; D001826:Body Fluids / Q000737:chemistry*; D002245:Carbon Dioxide; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D005746:Gastric Emptying; D011109:Polymethacrylic Acids; D016062:Porosity; D017693:Sodium Bicarbonate; D013270:Stomach; D013607:Tablets
chemical_list: D018712:Analgesics, Non-Narcotic; D004337:Drug Carriers; D011109:Polymethacrylic Acids; D013607:Tablets; D002245:Carbon Dioxide; C038300:methylmethacrylate-methacrylic acid copolymer; D000082:Acetaminophen; D017693:Sodium Bicarbonate