title: Antibodies to hepatitis B virus surface antigen and survival of hemodialysis patients - a prospective study.
abstract: Antibodies to hepatitis B virus (HBV) surface antigen (anti-HBs) may develop in response to HBV vaccination or infection. We investigated whether anti-HBs are an independent predictor of survival in hemodialysis (HD) patients.
  
  
  
  A 6-year prospective study was conducted in 532 HD patients. Survival analyses were performed using the Kaplan-Meier method and the Cox proportional hazard model.
  
  
  
  In HBV non-infected patients, age (P = 0.005), coronary artery disease (P = 0.002), and non-response to HBV vaccine (P = 0.008) were the independent risk factors of all-cause mortality. In HBV infected patients, the only independent predictor of all-cause mortality was coronary artery disease (P = 0.002).
  
  
  
  The ability to produce the protective anti-HBs titer in response to HBV vaccine is a positive predictor of survival in HBV non-infected HD patients.
authors.affiliation: a Department of Nephrology, Transplantology and Internal Diseases , Poznan University of Medical Sciences (PUMS) , Poznań , Poland.
authors.forename: Alicja E
authors.initials: AE
authors.lastname: Grzegorzewska
authors.affiliation: b Student Nephrology Research Group , PUMS , Poznań , Poland.
authors.forename: Monika K
authors.initials: MK
authors.lastname: Świderska
authors.affiliation: c Department of Biophysics , PUMS , Poznań , Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Warchoł
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000401:mortality* / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects*; D013534:Survival; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens
keywords: Age; HBV infection; HBV vaccination; anti-HBs titer; coronary artery disease; diabetic nephropathy; hemodialysis; hepatitis B virus; parathyroid hormone; survival probability