title: Vaccines: could asthma in young children be a preventable disease? ‬‬‬‬‬‬‬.
abstract: ‬The long battle with asthma is far from over in developed countries. Its incidence, prevalence, and severity have been increasing for decades. By reducing the risk for asthma, significant healthcare costs can be saved. The desire to create a vaccine that might prevent asthma in young children is attractive and widely considered one of the main goals in translational asthma research. Several vaccination strategies have been tested. These include allergen-specific immunotherapy, vaccination against infectious pathogens, and modification of cell and cytokine responses. The lack of success in the prevention of asthma in young children lies on the complexity of the disease, which involves many genetic, epigenetic, and environmental interactions. This review provides a summary of current literature and aims to address key questions how to develop vaccines to prevent asthma in young children. ‬‬‬‬‬‬‬‬‬‬‬‬‬‬.
authors.affiliation: Department of Pediatrics, Turku University Hospital, Turku, Finland.
authors.forename: Varpu
authors.initials: V
authors.lastname: Elenius
authors.affiliation: Department of Pediatrics, Turku University Hospital, Turku, Finland. tuomas.jartti@utu.fi.
authors.forename: Tuomas
authors.initials: T
authors.lastname: Jartti
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D003888:Desensitization, Immunologic / Q000379:methods*; D044127:Epigenesis, Genetic; D059647:Gene-Environment Interaction; D006801:Humans; D007223:Infant; D057170:Translational Research, Biomedical; D014611:Vaccination; D014612:Vaccines / Q000276:immunology*
chemical_list: D014612:Vaccines
keywords: allergy; asthma; bacteria; cytokine; immunomodulation; immunotherapy; prevention; rhinovirus; vaccine; virus