title: Double-Network Hydrogels Strongly Bondable to Bones by Spontaneous Osteogenesis Penetration.
abstract: On implanting hydroxyapatite-mineralized tough hydrogel into osteochondral defects of rabbits, osteogenesis spontaneously penetrates into the gel matrix owing to the semi-permeablility of the hydrogel. The gradient layer (around 40 μm thick) contributes quite strong bonding of the gel to bone. This is the first success in realizing the robust osteointegration of tough hydrogels, and the method is simple and feasible for practical use.
authors.affiliation: Faculty of Advanced Life Science, Hokkaido University, Sapporo, 060-0810, Japan.|Global Station for Soft Matter, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, 060-0810, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nonoyama
authors.affiliation: Department of Sports Medicine and Joint Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, 060-0810, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Wada
authors.affiliation: Graduate School of Life Science, Hokkaido University, Sapporo, 060-0810, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kiyama
authors.affiliation: Department of Sports Medicine and Joint Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, 060-0810, Japan.
authors.forename: Nobuto
authors.initials: N
authors.lastname: Kitamura
authors.affiliation: Graduate School of Life Science, Hokkaido University, Sapporo, 060-0810, Japan.
authors.forename: Md Tariful Islam
authors.initials: MT
authors.lastname: Mredha
authors.affiliation: Faculty of Fisheries Science, Hokkaido University, Hakodate, 041-8611, Japan.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Faculty of Advanced Life Science, Hokkaido University, Sapporo, 060-0810, Japan.|Global Station for Soft Matter, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, 060-0810, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kurokawa
authors.affiliation: Faculty of Advanced Life Science, Hokkaido University, Sapporo, 060-0810, Japan.|Global Station for Soft Matter, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, 060-0810, Japan.
authors.forename: Tasuku
authors.initials: T
authors.lastname: Nakajima
authors.affiliation: Faculty of Fisheries Science, Hokkaido University, Hakodate, 041-8611, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Takagi
authors.affiliation: Department of Sports Medicine and Joint Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, 060-0810, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Yasuda
authors.affiliation: Faculty of Advanced Life Science, Hokkaido University, Sapporo, 060-0810, Japan.|Global Station for Soft Matter, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, 060-0810, Japan.
authors.forename: Jian Ping
authors.initials: JP
authors.lastname: Gong
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D010012:Osteogenesis; D011817:Rabbits
chemical_list: D020100:Hydrogels; D017886:Durapatite
keywords: biomaterials; double-network hydrogels; hydroxyapatite; osteointegration; semi-permeability