title: Immunohistological Expression of p16INK4a is Commonly Present Both in Benign and Malignant Sweat Gland Neoplasias.
abstract: The expression of p16INK4a has been reported to be a significant marker for malignant transformation of epidermal tumors. However, little is known about sweat gland tumors. We examined the immunohistological expression of p16INK4a in benign and malignant sweat gland tumors. The ductal and acrosyringial portion of normal eccrine glands were positively stained with p16INK4a while it was negative in the normal epidermis. Moderate to strong expression of p16INK4a was found in 16 of 17 eccrine poromas, 4 of 5 hidradenomas, 3 of 3 syringocystadenoma papilliferums, 2 of 2 mixed tumors, and 3 of 3 syringomas. The p16INK4a expression was observed focally or diffusely in 4 of 4 porocarcinomas, 4 of 4 apocrine carcinomas and 12 of 17 extramammary Paget's diseases. We conclude that the p16INK4a expression is not a good marker for dictating malignant transformation of sweat gland tumors.
authors.forename: Jun
authors.initials: J
authors.lastname: Tsujita
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kaku
authors.forename: Toshio
authors.initials: T
authors.lastname: Ichiki
authors.forename: Ayaka
authors.initials: A
authors.lastname: Eto
authors.forename: Hiromi
authors.initials: H
authors.lastname: Maemura
authors.forename: Akiko
authors.initials: A
authors.lastname: Otsuka
authors.forename: Risa
authors.initials: R
authors.lastname: Nakaie
authors.forename: Noriko
authors.initials: N
authors.lastname: Kitagawa
authors.forename: Yuka
authors.initials: Y
authors.lastname: Morioka
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Matsuda
authors.forename: Maiko
authors.initials: M
authors.lastname: Yoshida
authors.forename: Masutaka
authors.initials: M
authors.lastname: Furue
mesh_terms: D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D013543:Sweat Gland Diseases / Q000378:metabolism* / Q000473:pathology; D013544:Sweat Gland Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16