title: Safety of Early Discharge After Primary Percutaneous Coronary Intervention.
abstract: In contrast to ST-elevation myocardial infarction treatment, there is no clear definition for when and which patient to discharge. Our study's main goal was to test the hypothesis that an early discharge strategy (within 48 to 56 hours) in patients with successful primary percutaneous coronary intervention (PPCI) is as safe as in patients who stay longer. The Early Discharge after Primary Percutaneous Coronary Intervention trial was designed in a prospective, randomized, multicenter fashion and registered with http://clinicaltrials.gov (NCT01860079). Of 900 patients with ST-elevation myocardial infarction, the study randomized 769 eligible patients to the early or the standard discharge group. The study's primary outcomes were all-cause mortality and readmission at 30 days. We considered assessment of functional status and health-related quality of life to be secondary outcomes. The early discharge group had significantly shorter length of hospital stay compared with the standard discharge group (45.99 ± 9.12 vs 114.87 ± 63.53 hours; p <0.0001). Neither all-cause mortality nor readmissions were different between the 2 study groups (p = 0.684 and p = 0.061, respectively). Quality-of-life measures were not statistically different between the 2 study groups. Our study reveals that discharge within 48 to 56 hours after successful PPCI is feasible, safe, and does not increase the 30-day readmission rate. Moreover, the patients perceived health status at 30 days did not differ with early discharge.
authors.affiliation: Cardiology Department, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: M Hulusi
authors.initials: MH
authors.lastname: Satılmısoglu
authors.affiliation: Cardiology Department, Acibadem University Medical Faculty, Istanbul, Turkey. Electronic address: sevket5@yahoo.com.
authors.forename: Sevket
authors.initials: S
authors.lastname: Gorgulu
authors.affiliation: Cardiology Department, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Hale Unal
authors.initials: HU
authors.lastname: Aksu
authors.affiliation: Cardiology Department, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Aksu
authors.affiliation: Cardiology Department, Dr. Siyami Ersek Chest and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Ertaş
authors.affiliation: Cardiology Department, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Tasbulak
authors.affiliation: Cardiology Department, Acibadem University Medical Faculty, Istanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Buturak
authors.affiliation: Cardiology Department, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ali Kemal
authors.initials: AK
authors.lastname: Kalkan
authors.affiliation: Cardiology Department, Acibadem University Medical Faculty, Istanbul, Turkey.
authors.forename: Aleks
authors.initials: A
authors.lastname: Degirmencioglu
authors.affiliation: Cardiology Department, Dr. Siyami Ersek Chest and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Bayram
authors.initials: B
authors.lastname: Koroglu
authors.affiliation: Cardiology Department, Dr. Siyami Ersek Chest and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Eyyup
authors.initials: E
authors.lastname: Tusun
authors.affiliation: Cardiology Department, Dr. Siyami Ersek Chest and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Murat
authors.affiliation: Cardiology Department, Dr. Siyami Ersek Chest and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Oz
mesh_terms: D002423:Cause of Death / Q000639:trends; D004562:Electrocardiography; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D007902:Length of Stay / Q000639:trends; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge / Q000639:trends*; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D000072657:ST Elevation Myocardial Infarction / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome