title: Doxorubicin-loaded mesoporous silica nanoparticle composite nanofibers for long-term adjustments of tumor apoptosis.
abstract: There is a high local recurrence (LR) rate in breast-conserving therapy (BCT) and enhancement of the local treatment is promising as a way to improve this. Thus we propose a drug delivery system using doxorubicin (DOX)-loaded mesoporous silica nanoparticle composite nanofibers which can release anti-tumor drugs in two phases-burst release in the early stage and sustained release at a later stage-to reduce the LR of BCT. In the present study, we designed a novel composite nanofibrous scaffold to realize the efficient release of drugs by loading both DOX and DOX-loaded mesoporous silica nanoparticles into an electrospun PLLA nanofibrous scaffold. In vitro results demonstrated that this kind of nanomaterial can release DOX in two phases, and the results of in vivo experiments showed that this hybrid nanomaterial significantly inhibited the tumor growth in a solid tumor model. Histopathological examination demonstrated that the apoptosis of tumor cells in the treated group over a 10 week period was significant. The anti-cancer effects were also accompanied with decreased expression of Bcl-2 and TNF-α, along with up-regulation of Bax, Fas and the activation of caspase-3 levels. The present study illustrates that the mesoporous silica nanoparticle composite nanofibrous scaffold could have anti-tumor properties and could be further developed as adjuvant therapeutic protocols for the treatment of cancer.
authors.affiliation: Department of Intensive Care Unit (ICU), Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Rd, Shanghai, 200233, People's Republic of China.
authors.forename: Ziming
authors.initials: Z
authors.lastname: Yuan
authors.forename: Yue
authors.initials: Y
authors.lastname: Pan
authors.forename: Ruoyu
authors.initials: R
authors.lastname: Cheng
authors.forename: Lulu
authors.initials: L
authors.lastname: Sheng
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Guoqing
authors.initials: G
authors.lastname: Pan
authors.forename: Qiming
authors.initials: Q
authors.lastname: Feng
authors.forename: Wenguo
authors.initials: W
authors.lastname: Cui
mesh_terms: D017209:Apoptosis; D004317:Doxorubicin; D006801:Humans; D057139:Nanofibers; D053758:Nanoparticles; D009369:Neoplasms; D016062:Porosity; D012822:Silicon Dioxide
chemical_list: D012822:Silicon Dioxide; D004317:Doxorubicin