title: Auditory Tones and Foot-Shock Recapitulate Spontaneous Sub-Threshold Activity in Basolateral Amygdala Principal Neurons and Interneurons.
abstract: In quiescent states such as anesthesia and slow wave sleep, cortical networks show slow rhythmic synchronized activity. In sensory cortices this rhythmic activity shows a stereotypical pattern that is recapitulated by stimulation of the appropriate sensory modality. The amygdala receives sensory input from a variety of sources, and in anesthetized animals, neurons in the basolateral amygdala (BLA) show slow rhythmic synchronized activity. Extracellular field potential recordings show that these oscillations are synchronized with sensory cortex and the thalamus, with both the thalamus and cortex leading the BLA. Using whole-cell recording in vivo we show that the membrane potential of principal neurons spontaneously oscillates between up- and down-states. Footshock and auditory stimulation delivered during down-states evokes an up-state that fully recapitulates those occurring spontaneously. These results suggest that neurons in the BLA receive convergent input from networks of cortical neurons with slow oscillatory activity and that somatosensory and auditory stimulation can trigger activity in these same networks.
authors.affiliation: Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.|Asia Pacific Centre for Neuromodulation, Queensland Brain Institute, Brisbane, Queensland, Australia.
authors.forename: François
authors.identifier: 0000-0001-5341-2197
authors.initials: F
authors.lastname: Windels
authors.affiliation: Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Shanzhi
authors.initials: S
authors.lastname: Yan
authors.affiliation: Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.|Asia Pacific Centre for Neuromodulation, Queensland Brain Institute, Brisbane, Queensland, Australia.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Stratton
authors.affiliation: Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Robert
authors.initials: R
authors.lastname: Sullivan
authors.affiliation: School of Biomedical Sciences, Charles Sturt University, Bathurst, New South Wales, Australia.
authors.forename: James W
authors.initials: JW
authors.lastname: Crane
authors.affiliation: Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.|Asia Pacific Centre for Neuromodulation, Queensland Brain Institute, Brisbane, Queensland, Australia.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Sah
mesh_terms: D000161:Acoustic Stimulation; D000758:Anesthesia; D000818:Animals; D001303:Auditory Cortex / Q000187:drug effects / Q000502:physiology; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology*; D066272:Basolateral Nuclear Complex / Q000187:drug effects / Q000502:physiology*; D004597:Electroshock; D005121:Extremities / Q000502:physiology*; D007395:Interneurons / Q000187:drug effects / Q000502:physiology*; D007530:Isoflurane / Q000494:pharmacology; D018408:Patch-Clamp Techniques; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D013788:Thalamus / Q000187:drug effects / Q000502:physiology; D014520:Urethane / Q000494:pharmacology
chemical_list: D014520:Urethane; D007530:Isoflurane