title: Prdm4 induction by the small molecule butein promotes white adipose tissue browning.
abstract: Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.
authors.affiliation: Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Korea.
authors.forename: No-Joon
authors.initials: NJ
authors.lastname: Song
authors.affiliation: Division of Life Sciences, Korea University, Seoul, Korea.
authors.forename: Seri
authors.initials: S
authors.lastname: Choi
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
authors.forename: Prashant
authors.initials: P
authors.lastname: Rajbhandari
authors.affiliation: Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Korea.
authors.forename: Seo-Hyuk
authors.initials: SH
authors.lastname: Chang
authors.affiliation: Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Korea.
authors.forename: Suji
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
authors.forename: Laurent
authors.initials: L
authors.lastname: Vergnes
authors.affiliation: Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Korea.
authors.forename: So-Mi
authors.initials: SM
authors.lastname: Kwon
authors.affiliation: Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Korea.
authors.forename: Jung-Hoon
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Department of Genetic Engineering, Sungkyunkwan University, Suwon, Korea.
authors.forename: Sukchan
authors.initials: S
authors.lastname: Lee
authors.affiliation: Natural Product Research Team, Gyeonggi Bio-Center, Gyeonggi Institute of Science and Technology Promotion, Suwon, Korea.
authors.forename: Jin-Mo
authors.identifier: 0000-0003-0218-810X
authors.initials: JM
authors.lastname: Ku
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.|Major of Functional Genomics, University of Science and Technology, Daejeon, Korea.
authors.forename: Jeong-Soo
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.|Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Reue
authors.affiliation: Division of Life Sciences, Korea University, Seoul, Korea.
authors.forename: Seung-Hoi
authors.initials: SH
authors.lastname: Koo
authors.affiliation: Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California, USA.|Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Tontonoz
authors.affiliation: Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Korea.
authors.forename: Kye Won
authors.initials: KW
authors.lastname: Park
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects* / Q000378:metabolism; D052436:Adipose Tissue, White / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D047188:Chalcones / Q000737:chemistry / Q000494:pharmacology*; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D014157:Transcription Factors / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D047188:Chalcones; D004268:DNA-Binding Proteins; C578289:PRDM4 protein, mouse; D014157:Transcription Factors; C040918:butein