title: Statins Reduce the Risk of Cirrhosis and Its Decompensation in Chronic Hepatitis B Patients: A Nationwide Cohort Study.
abstract: The protective effect of statins in cirrhosis and its decompensation in chronic hepatitis B (CHB) patients remains unknown.
  
  
  
  We conducted a population-based cohort study using data from the Taiwanese National Health Insurance Research Database from 1997 to 2009. A total of 298,761 CHB patients were identified. CHB patients using statins (n=6,543; defined as ≥28 cumulative defined daily doses (cDDD)) and a 1:1 ratio propensity score and inception point (the date of first use of statins)-matched non-statins (<28 cDDD) were followed up from the inception point until the development of cirrhosis or its decompensation or until withdrawal from insurance or December 2009.
  
  
  
  After adjustment for competing mortality, CHB patients using statins had a significantly lower cumulative incidence of cirrhosis (relative risk)=0.433; 95% confidence interval (CI)=0.344-0.515; modified log-rank test, P<0.001) and decompensated cirrhosis (relative risk=0.468; 95% CI=0.344-0.637; P<0.001) compared with patients not using statins. After adjustment for age, gender, comorbidity index, hypertension, diabetes, hyperlipidemia, hepatocellular carcinoma, obesity, non-alcoholic fatty liver disease, aspirin use, diabetes medication, CHB treatment, non-statin lipid-lowering drugs, and triglyceride lipid-lowering drugs using the Cox proportional hazard model, statins were still an independent protector against cirrhosis (adjusted hazard ratio (AHR)=0.512; 95% CI=0.413-0.634; P<0.001) and its decompensation (AHR=0.534; 95% CI=0.433-0.659; P<0.001). The AHRs for cirrhosis were 0.467 and 0.200, and the AHRs for decompensated cirrhosis were 0.611 and 0.231 with 91-365 and >365 cDDD of statins, respectively.
  
  
  
  CHB patients who receive statin therapy have a dose-dependent reduction in the risk of cirrhosis and its decompensation.
authors.affiliation: Liver Center, Cathay General Hospital Medical Center, Taipei, Taiwan.|School of Medicine, Taipei Medical University College of Medicine, Taipei, Taiwan.|Division of Gastroenterology, Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Yi-Wen
authors.initials: YW
authors.lastname: Huang
authors.affiliation: School of Medicine, Taipei Medical University College of Medicine, Taipei, Taiwan.|Division of Gastroenterology, Department of Internal Medicine, Cathay General Hospital Medical Center, Taipei, Taiwan.
authors.forename: Chia-Long
authors.initials: CL
authors.lastname: Lee
authors.affiliation: Liver Center, Cathay General Hospital Medical Center, Taipei, Taiwan.|School of Medicine, Fu-Jen Catholic University College of Medicine, Taipei, Taiwan.
authors.forename: Sien-Sing
authors.initials: SS
authors.lastname: Yang
authors.affiliation: Liver Center, Cathay General Hospital Medical Center, Taipei, Taiwan.
authors.forename: Szu-Chieh
authors.initials: SC
authors.lastname: Fu
authors.affiliation: Liver Center, Cathay General Hospital Medical Center, Taipei, Taiwan.|Institute of Health Policy and Management, National Taiwan University, Taipei, Taiwan.
authors.forename: Yun-Yi
authors.initials: YY
authors.lastname: Chen
authors.affiliation: Department of Medical Research, Cathay General Hospital Medical Center, Taipei, Taiwan.
authors.forename: Ting-Chuan
authors.initials: TC
authors.lastname: Wang
authors.affiliation: Liver Center, Cathay General Hospital Medical Center, Taipei, Taiwan.|School of Medicine, Fu-Jen Catholic University College of Medicine, Taipei, Taiwan.
authors.forename: Jui-Ting
authors.initials: JT
authors.lastname: Hu
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.|Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.|Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan.|Genomics Research Center, Academia Sinica, Nankang, Taiwan.
authors.forename: Ding-Shinn
authors.initials: DS
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D015897:Comorbidity; D018450:Disease Progression; D050171:Dyslipidemias / Q000188:drug therapy; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D015994:Incidence; D007345:Insurance Claim Review / Q000706:statistics & numerical data; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D065840:Protective Factors; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors