title: Utility of Cystatin C for Estimating Glomerular Filtration Rate in Patients With Muscular Dystrophy.
abstract: Emerging concerns regarding heart failure, arrhythmia, and sudden death in patients with muscular dystrophy are of significant clinical importance. On the other hand, little attention has been paid to renal dysfunction because these patients have low serum creatinine levels. Serum cystatin C, unaffected by muscle quantity, is a potentially superior marker for estimating renal function. Here, we present cases with muscular dystrophy in which estimated glomerular filtration rate (GFR) by cystatin C (eGFRcys) provided good agreement with simultaneously measured GFR by inulin renal clearance (differences less than 20%). Sudden death with acute heart failure occurred in a patient with underlying renal dysfunction and elevated BNP. Neurologists and cardiologists should evaluate renal function using GFR with cystatin C in patients with muscular dystrophy.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.
authors.forename: Koichi
authors.initials: K
authors.lastname: Kimura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Morita
authors.forename: Masao
authors.initials: M
authors.lastname: Daimon
authors.forename: Masaru
authors.initials: M
authors.lastname: Horio
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kawata
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakao
authors.forename: Megumi
authors.initials: M
authors.lastname: Hirokawa
authors.forename: Ruriko
authors.initials: R
authors.lastname: Kitao
authors.forename: Daisuke
authors.initials: D
authors.lastname: Watanabe
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Komori
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Nagata
authors.forename: Shin'ichi
authors.initials: S
authors.lastname: Takeda
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Komaki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Segawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakajima
authors.forename: Katsu
authors.initials: K
authors.lastname: Takenaka
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism*; D055316:Cystatin C / Q000378:metabolism*; D019468:Disease Management; D042241:Early Diagnosis; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009136:Muscular Dystrophies / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D051437:Renal Insufficiency / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D003404:Creatinine