title: Emergence of Serratia marcescens isolates possessing carbapenem-hydrolysing β-lactamase KPC-2 from China.
abstract: Eighty-three carbapenem-resistant Serratia marcescens isolates were recovered from Zhejiang Provincial People's Hospital, China. The minimum inhibitory concentrations of imipenem, meropenem, and ertapenem for all isolates were 2 to >128 μg/mL. Polymerase chain reaction indicated that 63 S. marcescens isolates produced Klebsiella pneumoniae carbapenemase (KPC)-2. Clone A (15 isolates) and clone B (41 isolates) were the two dominant clones and clone A strains were gradually replaced by clone B strains between 2011 and 2014. The results indicate that blaKPC-2-positive S. marcescens emerged in our hospital as the major mechanism of carbapenem resistance.
authors.affiliation: Centre of Laboratory Medicine, Zhejiang Provincial People's Hospital, Hangzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Lin
authors.affiliation: Centre of Laboratory Medicine, Zhejiang Provincial People's Hospital, Hangzhou, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
authors.forename: R
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Zhejiang Chinese Medical University, Hangzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Xu
authors.affiliation: Centre of Laboratory Medicine, Zhejiang Provincial People's Hospital, Hangzhou, China. Electronic address: lab_lhx@126.com.
authors.forename: H
authors.initials: H
authors.lastname: Lv
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D015780:Carbapenems / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D004269:DNA, Bacterial / Q000235:genetics; D000077727:Ertapenem; D005260:Female; D005838:Genotype; D006761:Hospitals; D006801:Humans; D006868:Hydrolysis; D015378:Imipenem / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058889:Molecular Typing; D016133:Polymerase Chain Reaction; D016868:Serratia Infections / Q000453:epidemiology* / Q000382:microbiology*; D012706:Serratia marcescens / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D013845:Thienamycins / Q000378:metabolism / Q000494:pharmacology; D055815:Young Adult; D001618:beta-Lactamases / Q000235:genetics*; D047090:beta-Lactams / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D004269:DNA, Bacterial; D013845:Thienamycins; D047090:beta-Lactams; D015378:Imipenem; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases; D000077731:Meropenem; D000077727:Ertapenem
keywords: Carbapenem; Carbapenemase; ERIC–PCR; KPC-2; Resistance; Serratia marcescens