title: [Para-phenylenediamine allergic contact dermatitis due to henna tattoos in a child and adolescent population].
abstract: BACKGROUND
  Henna tattoos are a very common practice in the adolescent population. Henna is very often admixed with para-phenylenediamine (PPDA) to improve the appearance of the tattoo. PPDA is a potent allergen, and is a frequent cause of allergic contact dermatitis (ACD).
  
  
  METHODS
  A study was conducted on the results of 726 consecutive children who had been patch tested in the University General Hospital Consortium of Valencia between 1980 and 2015.
  
  
  RESULTS
  Almost half (49.7%; (361 cases) of the children had one or more positive patch test findings, with 4.7% (34) being allergic to PPDA. Mean age of patients allergic to PPDA was 12.4 years, and 44.2% were male. There were 2 cases (5.9%) of atopic dermatitis. Of the positive reactions, 73.5% were considered to be current clinically relevant. The sensitisation origin was a Henna tattoo in 50% of cases.
  
  
  CONCLUSIONS
  PPDA sensitisation is relatively common in the child and adolescent population. The most frequent origin is the performing of Henna tattoos adulterated with PPDA. Adolescents are at the higher risk of developing ACD due to Henna tattoos. Henna tattooing should be strongly discouraged in children.
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España. Electronic address: josema.ortiz.salvador@gmail.com.
authors.forename: José María
authors.initials: JM
authors.lastname: Ortiz Salvador
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Altea
authors.initials: A
authors.lastname: Esteve Martínez
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Daniela
authors.initials: D
authors.lastname: Subiabre Ferrer
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Ana Mercedes
authors.initials: AM
authors.lastname: Victoria Martínez
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Jesús
authors.initials: J
authors.lastname: de la Cuadra Oyanguren
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Violeta
authors.initials: V
authors.lastname: Zaragoza Ninet
mesh_terms: D000293:Adolescent; D002648:Child; D004396:Coloring Agents / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D010655:Phenylenediamines / Q000009:adverse effects*; D015995:Prevalence; D013653:Tattooing / Q000009:adverse effects*
chemical_list: D004396:Coloring Agents; D010655:Phenylenediamines; C029728:4-phenylenediamine
keywords: Alergia cutánea; Allergic contact dermatitis; Black henna; Dermatitis alérgica de contacto; Henna negra; Para-phenylenediamine; Parafenilendiamina; Patch test; Pruebas epicutáneas; Skin allergy; Tatuajes temporales; Temporary tattoo