title: Identification of a Novel HIV-1 Circulating Recombinant Form (CRF85_BC) in Sichuan, China.
abstract: We report a novel HIV circulating recombinant form (CRF B/C) identified from 10 epidemiologically unlinked individuals in Sichuan province, China, all self-report infected by heterosexual behavior. Sequencing and analyzing the near-full-length genome of these strains revealed this recombinant form to be composed of subtype B (China and Thailand) and subtype C (China and India), with three subtype B segments inserted into the pol, vpu, and nef regions of the subtype C backbone. To our knowledge, this identified HIV-1 recombinant form differs from previously documented B/C forms in its distinct backbone, inserted fragment size, and breakpoints. In agreement with the current HIV nomenclature system, this novel recombinant form constitutes a novel CRF (CRF85_BC). Our present findings further enrich the diversity of the prevalent HIV-1 CRFs in China.
authors.affiliation: 1 Sichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and Prevention , Chengdu, Sichuan Province, People's Republic of China .
authors.forename: Ling
authors.initials: L
authors.lastname: Su
authors.affiliation: 1 Sichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and Prevention , Chengdu, Sichuan Province, People's Republic of China .
authors.forename: Dongbin
authors.initials: D
authors.lastname: Wei
authors.affiliation: 1 Sichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and Prevention , Chengdu, Sichuan Province, People's Republic of China .
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: 1 Sichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and Prevention , Chengdu, Sichuan Province, People's Republic of China .
authors.forename: Yali
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: 1 Sichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and Prevention , Chengdu, Sichuan Province, People's Republic of China .
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.affiliation: 1 Sichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and Prevention , Chengdu, Sichuan Province, People's Republic of China .
authors.forename: Dan
authors.initials: D
authors.lastname: Yuan
authors.affiliation: 1 Sichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and Prevention , Chengdu, Sichuan Province, People's Republic of China .
authors.forename: Liao
authors.initials: L
authors.lastname: Feng
authors.affiliation: 2 State Key Laboratory of Infectious Disease Prevention and Control (SKLID), Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention (China CDC), Beijing, People's Republic of China .
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Ruan
authors.affiliation: 1 Sichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and Prevention , Chengdu, Sichuan Province, People's Republic of China .
authors.forename: Guangmin
authors.initials: G
authors.lastname: Qin
authors.affiliation: 1 Sichuan Provincial Center for Disease Control and Prevention, Center for AIDS/STD Control and Prevention , Chengdu, Sichuan Province, People's Republic of China .
authors.forename: Shu
authors.initials: S
authors.lastname: Liang
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D019143:Evolution, Molecular; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D011995:Recombination, Genetic