title: Patterns of Care and Outcomes of Adjuvant Radiotherapy for Meningiomas: A Surveillance, Epidemiology, and End Results and Medicare Linked Analysis.
abstract: BACKGROUND
  The role of adjuvant stereotactic radiosurgery (SRS) and fractionated radiotherapy (XRT) are unknown in patients with resected meningiomas.
  
  
  OBJECTIVE
  To identify patterns of care and outcomes of adjuvant radiotherapy for meningiomas in the Linked Surveillance, Epidemiology, and End Results (SEER) Medicare data.
  
  
  METHODS
  A total of 1,964 patients older than 66 years included in the SEER-Medicare data, who were diagnosed with meningioma, and underwent craniotomy were included for analysis.
  
  
  RESULTS
  Patients were less likely to receive adjuvant therapy if they were older than 75 (OR 0.730, 95% CI 0.548-0.973), female sex (OR 0.731, 95% CI 0.547-0.978), or unmarried (OR 0.692, 95% CI 0.515-0.929). Patients were more likely to receive adjuvant treatment for Grade II/III tumors (OR 5.586, 95% CI 2.135-13.589), tumors over 5 cm (OR 1.850, 95% CI 1.332-2.567), or partial resection (OR 3.230, 95% CI 2.327-4.484). Yearly between 2000 and 2009, 10.65 - 19.77% of patients received adjuvant therapy. Although no survival benefit was seen with the addition of adjuvant therapy (p = 0.1236), the subgroup of patients receiving SRS had a decreased risk of death compared to those receiving surgery alone (aHR 0.544, 95% CI 0.318 - 0.929).
  
  
  CONCLUSIONS
  Utilization of adjuvant XRT and SRS remained stable between 2000 and 2010. Male sex, young age, marriage, partial resection, Grade II/III tumors, and large tumors predicted the use of adjuvant therapy. For all patients, SRS decreased the risk of death compared to craniotomy alone.
authors.affiliation: Radiation Oncology, University of Louisville.
authors.forename: Mark
authors.initials: M
authors.lastname: Amsbaugh
authors.affiliation: Department of Neurosurgery, University of Louisville.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Ugiliweneza
authors.affiliation: Neuroncology, University of Louisville.
authors.forename: Eric
authors.initials: E
authors.lastname: Burton
authors.affiliation: Department of Neurosurgery, Stanford University School of Medicine.
authors.forename: Stephen
authors.initials: S
authors.lastname: Skirboll
authors.affiliation: Radiation Oncology, University of Louisville.
authors.forename: Shiao
authors.initials: S
authors.lastname: Woo
authors.affiliation: Department of Neurosurgery, University of Louisville.
authors.forename: Max
authors.initials: M
authors.lastname: Boakye
keywords: adjuvant radiotherapy; meningioma; radiosurgery