title: Jackhammer oesophagus in a case of linitis plastica.
abstract: A 52-year-old Caucasian woman presented with progressive nausea and vomiting, weight loss, and burning epigastric and chest pain. Initial oesophagogastroduodenoscopy (OGD) with biopsies demonstrated gastritis in absence of Helicobacter pylori A gastric emptying study, CT scan with pancreatic protocol and a colonoscopy revealed no concerning findings. Calcium channel blockers and proton pump inhibitors offered little improvement. A high-resolution oesophageal impedance manometry was performed, which was significant for jackhammer oesophagus with maximum distal contractile index 11 052 mm Hg-s-cm. Another OGD was carried out for Botox injection to oesophagogastric junction. Repeat gastric biopsies reported gastric adenocarcinoma, further diagnosed as stage 4 linitis plastica with metastatic peritoneal carcinomatosis. To the best of our knowledge, this is the only case of linitis plastica associated with jackhammer oesophagus.
authors.affiliation: Department of Medicine, University of Florida, Gainesville, Florida, USA.
authors.forename: Naueen Akbar
authors.initials: NA
authors.lastname: Chaudhry
authors.affiliation: Division of Gastroenterology and Liver Diseases, Montefiore Hospital and Medical Center, Bronx, New York, USA.
authors.forename: Kamran
authors.initials: K
authors.lastname: Zahid
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of Florida, Gainesville, Florida, USA.
authors.forename: Roxana
authors.initials: R
authors.lastname: Coman
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of Florida, Gainesville, Florida, USA.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D002945:Cisplatin / Q000627:therapeutic use; D003113:Colonoscopy; D003937:Diagnosis, Differential; D000077143:Docetaxel; D004947:Esophagus / Q000000981:diagnostic imaging* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008039:Linitis Plastica / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000556:secondary*; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D043823:Taxoids / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil