title: Systemic oxidative DNA and RNA damage are not increased during early phases of psychosis: A case control study.
abstract: It has been suggested that patients with schizophrenia develop higher levels of oxidative stress, which may contribute to deteriorating mental illness. In order to examine oxidative stress in the early stages of severe mental illness, we examined the levels of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, perceived stress and recent life events in patients at ultra high-risk (UHR) of developing psychosis, in antipsychotic naïve patients with first-episode schizophrenia (FES), and in healthy controls. We included 41 UHR patients, 35 FES patients, and 29 healthy controls. There was no difference in the level of DNA/RNA oxidative damage between UHR patients and FES patients compared with healthy controls. We found no association between levels of DNA/RNA oxidative damage and perceived stress/life events. Based on the results, we suggest that DNA and RNA oxidative markers are not increased during the early stages of illness, but further longitudinal studies in first-episode psychosis should be carried out to examine whether DNA and RNA oxidative damage are potential markers of severe illness.
authors.affiliation: Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark; Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Center Glostrup, Copenhagen University Hospital, Denmark. Electronic address: dorte.nordholm@regionh.dk.
authors.forename: Dorte
authors.initials: D
authors.lastname: Nordholm
authors.affiliation: Laboratory of Clinical Pharmacology, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark.
authors.forename: Henrik Enghusen
authors.initials: HE
authors.lastname: Poulsen
authors.affiliation: Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark.
authors.forename: Carsten
authors.initials: C
authors.lastname: Hjorthøj
authors.affiliation: Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark; Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Center Glostrup, Copenhagen University Hospital, Denmark.
authors.forename: Lasse
authors.initials: L
authors.lastname: Randers
authors.affiliation: Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Center Glostrup, Copenhagen University Hospital, Denmark; Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Center Glostrup, Copenhagen University Hospital, Denmark.
authors.forename: Mette Ø
authors.initials: MØ
authors.lastname: Nielsen
authors.affiliation: Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Center Glostrup, Copenhagen University Hospital, Denmark; Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Center Glostrup, Copenhagen University Hospital, Denmark.
authors.forename: Sanne
authors.initials: S
authors.lastname: Wulff
authors.affiliation: Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark; Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Center Glostrup, Copenhagen University Hospital, Denmark.
authors.forename: Kristine
authors.initials: K
authors.lastname: Krakauer
authors.affiliation: Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Center Glostrup, Copenhagen University Hospital, Denmark; Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Center Glostrup, Copenhagen University Hospital, Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Nørbak-Emig
authors.affiliation: Laboratory of Clinical Pharmacology, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark.
authors.forename: Trine
authors.initials: T
authors.lastname: Henriksen
authors.affiliation: Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Center Glostrup, Copenhagen University Hospital, Denmark; Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Center Glostrup, Copenhagen University Hospital, Denmark.
authors.forename: Birte
authors.initials: B
authors.lastname: Glenthøj
authors.affiliation: Mental Health Center Copenhagen, Copenhagen University Hospital, Denmark.
authors.forename: Merete
authors.initials: M
authors.lastname: Nordentoft
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D004247:DNA / Q000652:urine*; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006151:Guanosine / Q000031:analogs & derivatives / Q000652:urine; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D012313:RNA / Q000652:urine*; D012307:Risk Factors; D012559:Schizophrenia / Q000652:urine*; D012565:Schizophrenic Psychology; D013315:Stress, Psychological / Q000523:psychology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006151:Guanosine; C046215:8-hydroxyguanosine; D012313:RNA; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D003849:Deoxyguanosine