title: Adiponectin Exerts Neurotrophic Effects on Dendritic Arborization, Spinogenesis, and Neurogenesis of the Dentate Gyrus of Male Mice.
abstract: The hippocampus, a brain region critical for learning, memory and emotional processing, maintains its capacity to undergo structural plasticity throughout life. Hippocampal structural plasticity can be modulated by a number of intrinsic and extrinsic factors. This study investigated the effects of adiponectin, an adipocyte-derived hormone, on dendritic growth, arborization, and spinogenesis in mature granule neurons of the hippocampal dentate gyrus generated during embryonic (early-born) or early postnatal (late-born) stages. We found that adiponectin deficiency reduced dendritic length, branching and spine density of granule neurons. The reduction was more evident in early-born granule neurons than in late-born granule neurons. Intracerebroventricular infusion of adiponectin for 1 week increased of dendritic spines and arbor complexity in late-born granule neurons. Moreover, adiponectin deficiency decreased the production of adult-born new granule neurons through suppressing neural progenitor cell proliferation and differentiation, whereas intracerebroventricular adiponectin infusion increased the proliferation of neural progenitor cells in adult dentate gyrus. These results suggest that adiponectin plays an important role in dendritic spine remodeling and neurogenesis in the dentate gyrus.
authors.affiliation: Department of Pharmacology, University of Texas Health Science Center at San Antonio, Texas 78229.
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, University of Texas Health Science Center at San Antonio, Texas 78229.
authors.forename: Xuezhen
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, University of Texas Health Science Center at San Antonio, Texas 78229.
authors.forename: Xin-Yun
authors.initials: XY
authors.lastname: Lu
mesh_terms: D052242:Adiponectin / Q000235:genetics* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics*; D049109:Cell Proliferation / Q000187:drug effects / Q000235:genetics*; D003712:Dendrites / Q000187:drug effects / Q000378:metabolism*; D049229:Dendritic Spines / Q000187:drug effects / Q000378:metabolism*; D018891:Dentate Gyrus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D058953:Neural Stem Cells / Q000187:drug effects / Q000378:metabolism; D055495:Neurogenesis / Q000187:drug effects / Q000235:genetics*
chemical_list: D052242:Adiponectin