title: [Correlations between Vessel Changes and the Histopathologic Subtypes of Lung Adenocarcinoma with Pure Ground-glass Nodule on Computed Tomography].
abstract: OBJECTIVE
  To investigate the correlations between vessel changes and the histopathologic subtypes of lung adenocarcinoma with pure ground-glass nodule (pGGN) on computed tomography (CT).
  
  
  METHODS
  Totally 107 patients (116 lesions) with lung adenocarcinomas with pGGN who had undergone curative resection were included. Vessel changes included vascular convergence and/or vessel dilation or distortion within the pGGN. According to the vessel appearances within the pGGN, all patients were categorized into two groups: no change group and change group. Pearson chi-square test was used to analyze the relationships between vessel changes and histopathologic subtypes. Mann-Whitney rank test and t-test were used to identify the relationship of vessels changes with pGGN density and diameter.
  
  
  RESULTS
  Among these 116 pGGNs, there were 21 without vessel changes and 4 with vessel changes in 25 preinvasive lesions; 14 without vessel changes and 15 with vessel changes in 29 minimally invasive adenocacinomas; 16 without vessel changes and 46 with vessel changes in 62 invasive lung adenocarcinomas. There were statistically significant differences of vessel changes (P=0.000) among histopathologic subtypes. The lesion diameter was significantly different between these two groups (P=0.000), while the lesion density showed no significant difference (P=0.826).
  
  
  CONCLUSIONS
  Vessel changes may indicate the invasiveness of lung adenocarcinoma with pGGNs and are related with the lesion diameter.
authors.affiliation: Department of Radiology,Chinese PLA General Hospital,Beijing 100853,China.
authors.forename: Yue-qing
authors.initials: YQ
authors.lastname: Yang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Lü
authors.affiliation: Department of Pathology,Chinese PLA General Hospital,Beijing 100853,China.
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Radiology,Chinese PLA General Hospital,Beijing 100853,China.
authors.forename: Xin
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of Radiology,Chinese PLA General Hospital,Beijing 100853,China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wu
authors.affiliation: Department of Radiology,Chinese PLA General Hospital,Beijing 100853,China.
authors.forename: Mei
authors.initials: M
authors.lastname: Jin
authors.affiliation: Department of Radiology,Chinese PLA General Hospital,Beijing 100853,China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Radiology,Chinese PLA General Hospital,Beijing 100853,China.
authors.forename: Shao-hong
authors.initials: SH
authors.lastname: Zhao
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D016009:Chi-Square Distribution; D006801:Humans; D008175:Lung Neoplasms / Q000145:classification / Q000473:pathology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed