title: The correlation between Ki-67 with other prognostic factors in breast cancer: A study in Iranian patients.
abstract: BACKGROUND
  Despite the fact that breast cancer (BC) is a major health issue, very few studies describe its characteristics in the Middle East.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the use and value of Ki-67 as a prognostic marker in BC and associations between Ki-67, clinical, and histopathological parameters were evaluated.
  
  
  METHODS
  In a retrospective study, 260 BC women and invasive ductal carcinoma were included to our study in Kermanshah city, Iran. Age, tumor size, lymph node involvement, histological grade, nuclear grade, and vascular invasion were other factors that determined in a lot of patients.
  
  
  RESULTS
  The mean age at diagnosis was 47.6 years (range, 24-84 years) with 100% female. Of 243 patients that tumor size was determined for them, 207 patients (85.2%) had tumor size ≥2 cm, and 36 patients (14.8%) had size <2 cm and also of 237 patients, 47 patients (19.8%), 140 (59.1%), and 50 (21.1%) had histological grades I, II, and III, respectively. There is significant correlation between Ki-67 with nuclear grade, human epidermal growth factor receptor 2 (HER2), and p53 (P < 0.05). Based on this result, more patients with Ki-67 ≥20% have higher nuclear grade, p53-positive, and HER2-positive. There was correlation between Ki-67 with type of tumor (P = 0.009).
  
  
  CONCLUSIONS
  The higher Ki-67 has a direct significant correlation with higher nuclear grade, p53-positive, and HER2-positive. Furthermore, triple negative patients have higher Ki-67 compared to other subtypes.
authors.affiliation: Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Seyed-Hamid
authors.initials: SH
authors.lastname: Madani
authors.affiliation: Department of Hematology and Medical Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Payandeh
authors.affiliation: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Sadeghi
authors.affiliation: Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Hajar
authors.initials: H
authors.lastname: Motamed
authors.affiliation: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Edris
authors.initials: E
authors.lastname: Sadeghi
keywords: Breast cancer; Ki-67; P53; histological grade