title: A far-red, photo- and bio-stable fluorescent marker selective to the endoplasmic reticulum and its application to tunicamycin-treated HeLa cells.
abstract: Herein, we developed an ER selective fluorescent ERp that exhibited a sharp fluorescence emission in the far-red region and high photo- and bio-stability in biological milieu. Its emission is insensitive to pH change and localized in the ER of the cells. Furthermore, it successfully demonstrated that the ER membrane is rapidly reorganized in the perinuclear region by an ER stress inducer, tunicamycin.
authors.affiliation: The School of East-West Medical Science, Kyung Hee University, Yongin, 446-701, Korea. kangch@khu.ac.kr.
authors.forename: Hye-Ri
authors.initials: HR
authors.lastname: Kim
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Woori
authors.initials: W
authors.lastname: Kim
authors.forename: Jae Hong
authors.initials: JH
authors.lastname: Lee
authors.forename: Myungkoo
authors.initials: M
authors.lastname: Suh
authors.forename: Amit
authors.initials: A
authors.lastname: Sharma
authors.forename: Chang Hoe
authors.initials: CH
authors.lastname: Kim
authors.forename: Chulhun
authors.initials: C
authors.lastname: Kang
authors.forename: Jong
authors.initials: J
authors.lastname: Seung Kim
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014415:Tunicamycin / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D014408:Biomarkers, Tumor; D005456:Fluorescent Dyes; D014415:Tunicamycin