title: Preparation of Synaptosomes from the Motor Cortex of Motor Skill Trained Mice.
abstract: Learning and memory are thought to occur due to changes in synaptic strength. Strengthening of synapses due to Long Term Potentiation mechanisms are mediated by increases in synaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) levels. Here we describe a protocol to isolate and quantify synaptic AMPAR subunit GluA1 levels from the motor cortex of mice which have undergone motor skill training.
authors.affiliation: Department of Developmental Neuroscience, University of Nebraska Medical Center, Omaha, USA.
authors.forename: Anand
authors.initials: A
authors.lastname: Suresh
authors.affiliation: Department of Developmental Neuroscience, University of Nebraska Medical Center, Omaha, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Dunaevsky