title: The MDM2 T309G polymorphism and risk of lung cancer: an updated meta-analysis of 10,186 cases and 14,155 controls.
abstract: BACKGROUND
  The aim of this paper was to assess the relationship between MDM2 (mouse double minute 2 homolog) T309G polymorphism and the risk and prognosis of lung cancer.
  
  
  METHODS
  We did a systematic review of relevant articles from EBSCO, EMBASE, Web of science, PubMed, springer link, science direct, weipu database and CNKI (Chinese National Knowledge Infrastructure) databases up to January 7, 2016.
  
  
  RESULTS
  Seventeen case-control studies and 5 cases prognosis were included. The results indicated that the MDM2 T309G polymorphism was associated with lung cancer risk. Subgroup analysis by ethnicity also showed that associations are significant in Asian. Five prognosis studies were also included. Patients with TT genotype had a higher survival rate at 20-months-follow-up compared with those who carried TG or GG genotype (TT vs. TG+GG: OR=0.34, 95% CI: 0.12-0.99, P<0.05).
  
  
  CONCLUSIONS
  MDM2 T309G polymorphism is associated with risk and prognosis of lung cancer. TT or T genotype may be associated with the reduced risk of lung cancer, especially in Asians. Meanwhile, TT genotype is also associated with the improved prognosis of the lung cancer.
authors.affiliation: Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, China - tianxiaodong301@163.com.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Tian
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Juntang
authors.initials: J
authors.lastname: Guo
authors.forename: Xi
authors.initials: X
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Liang
authors.forename: Naikang
authors.initials: N
authors.lastname: Zhou
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Hou
authors.forename: Yongfu
authors.initials: Y
authors.lastname: Ma
authors.forename: Hua
authors.initials: H
authors.lastname: Yu
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Ren
authors.forename: Kaijie
authors.initials: K
authors.lastname: Fan
authors.forename: Qing
authors.initials: Q
authors.lastname: Tian
mesh_terms: D016158:Genes, p53; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011379:Prognosis; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D017594:Publication Bias; D012306:Risk
chemical_list: C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2