title: Colochirosides A₁, A₂, A₃, and D, Four Novel Sulfated Triterpene Glycosides from the Sea Cucumber Colochirus robustus (Cucumariidae, Dendrochirotida).
abstract: Four new triterpene glycosides, colochirosides A₁ (1), A₂ (2), A₃ (3) and D (4), have been isolated from the sea cucumber Colochirus robustus (Cucumariidae, Dendrochirotida). Structures of the glycosides have been elucidated by 2D NMR spectroscopy and mass-spectrometry. Colochiroside D (4) has a new type of carbohydrate chain having the only sulfate group attached to C-6 of the third (glucose) monosaccharide residue. Cytotoxic activities of glycosides 1-4 against the ascite form of mouse Ehrlich carcinoma cells and hemolytic activity against mouse erythrocytes have been studied. Hemolytic activity of the glycosides was higher than cytotoxic. Glycosides 1, 3 and 4 demonstrated strong effects, whereas compound 2 showed only moderate activity.
authors.forename: Alexandra S
authors.initials: AS
authors.lastname: Silchenko
authors.forename: Anatoly I
authors.initials: AI
authors.lastname: Kalinovsky
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Avilov
authors.forename: Pelageya V
authors.initials: PV
authors.lastname: Andryjaschenko
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Dmitrenok
authors.forename: Vladimir I
authors.initials: VI
authors.lastname: Kalinin
authors.forename: Ekaterina A
authors.initials: EA
authors.lastname: Yurchenko
authors.forename: Igor Yu
authors.initials: IY
authors.lastname: Dolmatov
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006027:Glycosides / Q000737:chemistry*; D006461:Hemolysis / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D012616:Sea Cucumbers / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D014315:Triterpenes