title: Cutaneous cylindroma: it's all about MYB.
abstract: Cutaneous cylindroma is a rare benign tumour that occasionally turns into malignant cylindrocarcinoma. The cancer can be sporadic or emerge in the context of Brooke-Spiegler syndrome (BSS), an inheritable condition characterized by mutation of the gene CYLD, encoding a tumour suppressor protein that controls the activity of the transcription factor NF-kB. Sporadic cylindromas present histological features shared with adenoid cystic carcinoma (ACC), a head and neck cancer originating from salivary or other exocrine glands. Like ACCs, sporadic cylindromas express, although at lower frequency, the aberrant fusion transcript MYB-NFIB. In a paper recently published in the Journal of Pathology, the research teams led by Neil Rajan and Goran Stenman demonstrate that CYLD-defective cyclindromas in BSS patients are negative for the MYB-NFIB fusion. Only the wild-type MYB oncoprotein is activated in the majority of these tumours. RNA interference studies in cells derived from BSS patients indicate that ablating MYB expression results in a striking reduction of cylindroma cell proliferation, suggesting that MYB plays a pivotal role in the biology of this cancer. The take-home message of the study is that activation of MYB, in its wild-type form or fusion derivatives, is a common feature of spontaneous and hereditary cylindromas, constituting a potentially actionable therapeutic target. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
authors.affiliation: College of Health and Life Sciences, Brunel University, London, UK.|Institute of Environment, Health and Societies, Brunel University, London, UK.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Corda
authors.affiliation: College of Health and Life Sciences, Brunel University, London, UK.|Institute of Environment, Health and Societies, Brunel University, London, UK.
authors.forename: Arturo
authors.initials: A
authors.lastname: Sala
mesh_terms: D003528:Carcinoma, Adenoid Cystic / Q000235:genetics*; D006801:Humans; D016328:NF-kappa B; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics; D006113:United Kingdom
chemical_list: D016328:NF-kappa B
keywords: Brooke-Spiegler syndrome; CYLD; MYB; adenoid cystic carcinoma; cylindroma