title: Yes-Associated Protein in Hepatocellular Carcinoma is Associated with Tumor Differentiation and Patient Age at Diagnosis, but not Markers of HBV Infection.
abstract: BACKGROUND
  It was necessary to assess the relationship between Yes-associated protein (YAP) and some clinical features of hepatocellular carcinoma (HCC), especially hepatitis B virus (HBV) correlation factors as they relate to tumorigenesis.
  
  
  METHODS
  A tissue microarray including 84 HCC samples was retrospectively analyzed by immunohistochemistry.
  
  
  RESULTS
  This study showed that YAP expression was associated with HCC differentiation and the patient age at diagnosis of HCC. The mean age at diagnosis of YAP(+) HCC patients was 46.19 ± 9.45 years old, which is youn- ger than 51.40 ± 12.51 years old found for YAP(-) HCC patients (< 0.048). There was no significant correlation between YAP expression and HBV correlation factors (HBsAg, HBV DNA, and the duration of hepatitis B infec- tion).
  
  
  CONCLUSIONS
  YAP(+) HCC patients had a younger mean age at diagnosis and more poor-differentiation charac- teristics of HCC. However, there were no independent HBV correlation factors.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.forename: Zi-Man
authors.initials: ZM
authors.lastname: Zhu
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Liu
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: He
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Feng
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Jia-Hong
authors.initials: JH
authors.lastname: Dong
authors.forename: Hong-Yi
authors.initials: HY
authors.lastname: Zhang I
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000032:analysis*; D000328:Adult; D000367:Age Factors; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000209:etiology* / Q000473:pathology; D002454:Cell Differentiation; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D008113:Liver Neoplasms / Q000737:chemistry / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010750:Phosphoproteins / Q000032:analysis*; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human