title: [Renin and aldosterone determinations in hypertensive patients].
abstract: BACKGROUND
  The diagnostic algorithm of primary aldosteronism is burdened with uncertainties and, recently, it has been suggested that the sensitivity of the aldosterone/renin ratio used as a screening test - based on the suppression aldosterone - is low.
  
  
  OBJECTIVE
  The primary aim was to test the accuracy of aldosterone/renin ratio.
  
  
  METHODS
  In a retrospective analysis of 309 hypertensive patients supine and ambulatory aldosterone levels were independently examined.
  
  
  RESULTS
  Aldosterone/renin ratio was elevated in 99 patients of whom 31 exhibited elevated supine aldosterone, as well. In 34 cases supine aldosterone was increased without elevation of the aldosterone/renin ratio. However, only 3 of them had concomitant low renin levels indicating that primary aldosteronism could not be ruled out. Abnormally increased renin was found in 69 patients, but only 59% of them had increased aldosterone level.
  
  
  CONCLUSIONS
  Sensitivity of aldosterone/renin ratio is high (91%) if used only in justified cases.
authors.affiliation: I. Belgyógyászati Klinika, Pécsi Tudományegyetem Pécs, Ifjúság u. 13., 7624.
authors.forename: Tamás
authors.initials: T
authors.lastname: Hussein
authors.affiliation: I. Belgyógyászati Klinika, Pécsi Tudományegyetem Pécs, Ifjúság u. 13., 7624.
authors.forename: Emese
authors.initials: E
authors.lastname: Mezősi
authors.affiliation: I. Belgyógyászati Klinika, Pécsi Tudományegyetem Pécs, Ifjúság u. 13., 7624.
authors.forename: Beáta
authors.initials: B
authors.lastname: Bódis
authors.affiliation: I. Belgyógyászati Klinika, Pécsi Tudományegyetem Pécs, Ifjúság u. 13., 7624.
authors.forename: Orsolya
authors.initials: O
authors.lastname: Nemes
authors.affiliation: I. Belgyógyászati Klinika, Pécsi Tudományegyetem Pécs, Ifjúság u. 13., 7624.
authors.forename: Károly
authors.initials: K
authors.lastname: Rucz
authors.affiliation: I. Belgyógyászati Klinika, Pécsi Tudományegyetem Pécs, Ifjúság u. 13., 7624.
authors.forename: László
authors.initials: L
authors.lastname: Bajnok
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000450:Aldosterone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000175:diagnosis*; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012083:Renin / Q000097:blood*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016683:Supine Position; D016138:Walking
chemical_list: D015415:Biomarkers; D000450:Aldosterone; D012083:Renin
keywords: aldosteron/renin ratio; aldoszteron/renin hányados; diagnostic cut-off values; diagnosztikus határértékek; hyperaldosteronism; hyperaldosteronismus; primary aldosteronism; primer aldosteronismus; suppression aldosterone; szuppressziós aldoszteron