title: Time-dependency of mice lung recovery after a 4-week exposure to traffic or biomass air pollutants.
abstract: The time-dependency of lung recovery after 3 intranasal instillations per week during four weeks of distilled water (C groups) or particles (15μg) from traffic (U groups) or biomass burning (B groups) was observed in BALB/c mice. Lung mechanics [static elastance (Est), viscoelastic component of elastance (ΔE), lung resistive (ΔP1) and viscoelastic/inhomogeneous (ΔP2) pressures] and histology were analyzed 1 (C1, U1, B1), 2 (C2, U2, B2), 7 (C7, U7, B7) or 14 days (C14, U14, B14) after the last instillation. Est, ΔE, ΔP1 and ΔP2 were higher in U1 and B1 than in C1, returning to control values at day 2, except for ΔP1 that normalized after 7 days. Alveolar collapse, bronchoconstriction index and alveolar lesion were larger in U1 and B1 than in C1, however collapse returned to baseline at 7 days, while the others normalized in 2 days. A 4-week exposure to U and B induced lung impairment that resolved 7 days after the last exposure.
authors.affiliation: Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of do Rio de Janeiro, Brazil.
authors.forename: Flavia
authors.initials: F
authors.lastname: Mazzoli-Rocha
authors.affiliation: Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of do Rio de Janeiro, Brazil.
authors.forename: Vinícius Rosa
authors.initials: VR
authors.lastname: Oliveira
authors.affiliation: Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of do Rio de Janeiro, Brazil.
authors.forename: Bárbara Chaves
authors.initials: BC
authors.lastname: Barcellos
authors.affiliation: Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of do Rio de Janeiro, Brazil.
authors.forename: Dayse Kelly Molina
authors.initials: DK
authors.lastname: Moreira
authors.affiliation: Laboratory of Experimental Air Pollution, Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Paulo Hilário Nascimento
authors.initials: PH
authors.lastname: Saldiva
authors.affiliation: Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of do Rio de Janeiro, Brazil.
authors.forename: Débora Souza
authors.initials: DS
authors.lastname: Faffe
authors.affiliation: Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Federal University of do Rio de Janeiro, Brazil. Electronic address: wazin@biof.ufrj.br.
authors.forename: Walter Araújo
authors.initials: WA
authors.lastname: Zin
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001336:Automobiles; D060766:Drinking Water; D004548:Elasticity; D005260:Female; D008168:Lung / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology*; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D011312:Pressure; D011897:Random Allocation; D020127:Recovery of Function; D012129:Respiratory Function Tests; D031786:Saccharum; D012906:Smoke / Q000009:adverse effects; D013997:Time Factors; D014783:Viscosity
chemical_list: D000393:Air Pollutants; D060766:Drinking Water; D012906:Smoke
keywords: Air pollution; Lung mechanics; Lung morphometry; Particulate matter; Sugar cane burning