title: Laminin coatings on implant surfaces promote osseointegration: Fact or fiction?
abstract: To our knowledge from indexed literature, the role of laminins in the expression of osteogenic biomarkers and osseointegration enhancement has not been systematically reviewed. The aim of the present systematic review was to assess the role of laminin coatings on implant surfaces in promoting osseointegration. To address the focused question, "Do laminin coatings on implant surfaces influence osseointegration?", indexed databases were searched from 1965 up to and including November 2015 using various combination of the following keywords: "Bone to implant contact"; "implant"; "laminins"; and "osseointegration". Letters to the Editor, case-reports/case-series, historic reviews, and commentaries were excluded. The pattern of the present systematic review was customized to primarily summarize the pertinent data. Nine studies were included. Six studies were prospective and were performed in animals and 5 studies were in vitro. Results from 8 studies showed that laminin coatings enhanced new bone formation around implants and/or bone-to-implant contact. One study showed that laminin coated implants surfaces did not improve osseointegration. On experimental grounds, laminin coatings seem to enhance osteogenic biomarkers expression and/or osseointegration; however, from a clinical perspective, further randomized control trials are needed to assess the role of laminin coatings in promoting osseointegration around dental implants.
authors.affiliation: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, NY, USA. Electronic address: Fawad_Javed@urmc.rochester.edu.
authors.forename: Fawad
authors.initials: F
authors.lastname: Javed
authors.affiliation: Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Mohammad D
authors.initials: MD
authors.lastname: Al Amri
authors.affiliation: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, NY, USA.
authors.forename: Sergio Varela
authors.initials: SV
authors.lastname: Kellesarian
authors.affiliation: Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Mansour
authors.initials: M
authors.lastname: Al-Askar
authors.affiliation: Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh 11541, Saudi Arabia.
authors.forename: Abdulaziz A
authors.initials: AA
authors.lastname: Al-Kheraif
authors.affiliation: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, NY, USA; Department of Oral Surgery and Implant Dentistry, Dental School, Johann Wolfgang Goethe, University of Frankfurt, Frankfurt, Germany; Department of Periodontology, School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA.
authors.forename: Georgios E
authors.initials: GE
authors.lastname: Romanos
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D006801:Humans; D007797:Laminin / Q000737:chemistry* / Q000494:pharmacology; D016348:Osseointegration / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects; D011446:Prospective Studies; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D007797:Laminin; D014025:Titanium
keywords: Coated materials; Dental implants; Laminin; Osseointegration