title: Palladium-Catalyzed Oxidative N-Dealkylation/Carbonylation of Tertiary Amines with Alkynes to α,β-Alkynylamides.
abstract: The first highly effective Pd/C-catalyzed oxidative N-dealkylation/carbonylation of various aliphatic as well as cyclic tertiary amines with alkynes has been described. The selective sp(3) C-N bond activation of tertiary amines at the less steric side using O2 as a sole oxidant and a plausible reaction pathway for the reaction are discussed. The general and operationally simple methodology provides an alternative for the synthesis of a wide range of alk-2-ynamide derivatives under mild conditions. The present protocol is ecofriendly and practical, and it shows significant recyclability.
authors.affiliation: Department of Chemistry, Institute of Chemical Technology , Mumbai 400019, India.
authors.forename: Rajendra S
authors.initials: RS
authors.lastname: Mane
authors.affiliation: Department of Chemistry, Institute of Chemical Technology , Mumbai 400019, India.
authors.forename: Bhalchandra M
authors.initials: BM
authors.lastname: Bhanage