title: Properties and in vitro drug release of hyaluronic acid-hydroxyethyl cellulose hydrogels for transdermal delivery of isoliquiritigenin.
abstract: In the present study, the properties of hydrogel systems based on hyaluronic acid (HA)-hydroxyethyl cellulose (HEC) were investigated for effective transdermal delivery of isoliquiritigenin (ILTG). Hydrogels were synthesized by chemical cross-linking, and network structures were characterised using scanning electron microscopy (SEM) and surface area analyser. Texture properties and swelling of HA-HEC hydrogels were found to be closely linked to cross-linker concentration and swelling medium. Water in HA-HEC hydrogels was found to exist mostly in the form of free water. The viscoelasticity and the network stabilization of the hydrogels were analysed via rheological studies. The release kinetics of the hydrogel followed Fickian diffusion mechanism. In an in vitro skin penetration study, the system substantially improved the delivery of ILTG into the skin. These results indicate that the hydrogel system composed of HA and HEC has potential as a transdermal delivery system, with cross-linking density and the swelling medium influencing the properties.
authors.affiliation: Department of Fine Chemistry, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 01811, South Korea.
authors.forename: Bong Ju
authors.initials: BJ
authors.lastname: Kong
authors.affiliation: Department of Fine Chemistry, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 01811, South Korea.
authors.forename: Ayoung
authors.initials: A
authors.lastname: Kim
authors.affiliation: Department of Fine Chemistry, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 01811, South Korea. Electronic address: snpark@seoultech.ac.kr.
authors.forename: Soo Nam
authors.initials: SN
authors.lastname: Park
mesh_terms: D000279:Administration, Cutaneous; D002482:Cellulose / Q000737:chemistry; D047188:Chalcones / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006820:Hyaluronic Acid / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*
chemical_list: D047188:Chalcones; D020100:Hydrogels; D002482:Cellulose; D006820:Hyaluronic Acid; C040920:isoliquiritigenin
keywords: Divinyl sulfone (PubChem CID: 6496); Hyaluronic acid; Hyaluronic acid (PubChem CID: 24728612); Hydrogel; Hydroxyethyl cellulose (PubChem CID: 24846132); Isoliquiritigenin; Isoliquiritigenin (PubChem CID: 638278); Transdermal delivery system