title: Brain Radiation Information Data Exchange (BRIDE): integration of experimental data from low-dose ionising radiation research for pathway discovery.
abstract: BACKGROUND
  The underlying molecular processes representing stress responses to low-dose ionising radiation (LDIR) in mammals are just beginning to be understood. In particular, LDIR effects on the brain and their possible association with neurodegenerative disease are currently being explored using omics technologies.
  
  
  RESULTS
  We describe a light-weight approach for the storage, analysis and distribution of relevant LDIR omics datasets. The data integration platform, called BRIDE, contains information from the literature as well as experimental information from transcriptomics and proteomics studies. It deploys a hybrid, distributed solution using both local storage and cloud technology.
  
  
  CONCLUSIONS
  BRIDE can act as a knowledge broker for LDIR researchers, to facilitate molecular research on the systems biology of LDIR response in mammals. Its flexible design can capture a range of experimental information for genomics, epigenomics, transcriptomics, and proteomics. The data collection is available at: <bride.azurewebsites.net>.
authors.affiliation: Department of Genetics, Development & Molecular Biology, School of Biology, Aristotle University of Thessalonica, 54124, Thessalonica, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Karapiperis
authors.affiliation: Institute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764, Neuherberg, Germany.|Present address: Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark.
authors.forename: Stefan J
authors.initials: SJ
authors.lastname: Kempf
authors.affiliation: Radiobiology Unit, Belgian Nuclear Research Centre (SCK•CEN), B-2400, Mol, Belgium.
authors.forename: Roel
authors.initials: R
authors.lastname: Quintens
authors.affiliation: Institute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764, Neuherberg, Germany.
authors.forename: Omid
authors.initials: O
authors.lastname: Azimzadeh
authors.affiliation: School of Medicine, IISPV, "Rovira i Virgili" University, Sant Llorens 21, 43201, Reus, Spain.
authors.forename: Victoria Linares
authors.initials: VL
authors.lastname: Vidal
authors.affiliation: Laboratory of Radiation Biology & Biomedicine, Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile (ENEA) Centro Ricerche Casaccia, 00123, Rome, Italy.
authors.forename: Simonetta
authors.initials: S
authors.lastname: Pazzaglia
authors.affiliation: National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str. 53, Kyiv, 04050, Ukraine.
authors.forename: Dimitry
authors.initials: D
authors.lastname: Bazyka
authors.affiliation: Erasmus Medical Center, 3015GE, Rotterdam, The Netherlands.
authors.forename: Pier G
authors.initials: PG
authors.lastname: Mastroberardino
authors.affiliation: Department of Genetics, Development & Molecular Biology, School of Biology, Aristotle University of Thessalonica, 54124, Thessalonica, Greece.
authors.forename: Zacharias G
authors.initials: ZG
authors.lastname: Scouras
authors.affiliation: Institute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764, Neuherberg, Germany. soile.tapio@helmholtz-muenchen.de.
authors.forename: Soile
authors.initials: S
authors.lastname: Tapio
authors.affiliation: Radiobiology Unit, Belgian Nuclear Research Centre (SCK•CEN), B-2400, Mol, Belgium. abenotma@sckcen.be.
authors.forename: Mohammed Abderrafi
authors.initials: MA
authors.lastname: Benotmane
authors.affiliation: Department of Genetics, Development & Molecular Biology, School of Biology, Aristotle University of Thessalonica, 54124, Thessalonica, Greece. ouzounis@certh.gr.|Biological Process & Computation Laboratory (BCPL), Chemical Process & Energy Resources Institute (CPERI), Centre for Research & Technology Hellas (CERTH), Thessalonica, 57001, Greece. ouzounis@certh.gr.
authors.forename: Christos A
authors.initials: CA
authors.lastname: Ouzounis
mesh_terms: D001921:Brain / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D011839:Radiation, Ionizing; D012106:Research; D012984:Software
keywords: Brain research; Data integration; Low-dose ionising radiation; Omics technologies; Systems biology