title: Telomere Shortening in Middle-Aged Men with Sleep-disordered Breathing.
abstract: Sleep disorders may lead to stress-induced premature aging and telomere shortening.
  
  
  
  To determine whether obstructive sleep apnea syndrome causing intermittent hypoxemic episodes was associated with telomere shortening independently from the comorbidities associated with this syndrome.
  
  
  
  We conducted a cross-sectional study in 161prospectivelly enrolled, untreated, middle-aged men free of known comorbidities related or unrelated to sleep apnea. Each participant underwent full standard overnight polysomnography. Patients with apnea sleep syndrome were naive to treatment.
  
  
  
  In univariate analysis, we found that telomere shortening was associated with older age, apnea-hypopnea index, oxygen desaturation index, waist circumference, and fat mass. After adjustment for age, only apnea-hypopnea index and oxygen desaturation index were significantly related to telomere shortening. The mean telomere length ratio was 0.70 ± 0.37 in the participants without sleep apnea, compared with 0.61 ± 0.22 and 0.53 ± 0.16 in those with mild to moderate and severe sleep apnea, respectively (P = 0.01). In multivariate analysis, we found that oxygen desaturation index was the only factor independently associated with telomere length. Arterial stiffness assessed by carotid-femoral pulse wave velocity correlated negatively with telomere length.
  
  
  
  Intermittent hypoxemia due to obstructive sleep apnea syndrome is a major contributor to telomere shortening in middle-aged men. Oxidative stress may explain this finding.
authors.affiliation: 1 Département de Physiologie-Explorations Fonctionnelles, DHU-ATVB.|2 INSERM U955, Institut Mondor de Recherche Biomédicale.|3 Université Paris Est (UPEC), Faculté de Médecine, Créteil, France; and.
authors.forename: Laurent
authors.identifier: 0000-0002-2608-6696
authors.initials: L
authors.lastname: Boyer
authors.affiliation: 4 Service de Santé Publique.|3 Université Paris Est (UPEC), Faculté de Médecine, Créteil, France; and.|5 IMRB EA7376, Clinical Epidemiology and Aging (CEpiA), Créteil, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Audureau
authors.affiliation: 1 Département de Physiologie-Explorations Fonctionnelles, DHU-ATVB.
authors.forename: Laurent
authors.initials: L
authors.lastname: Margarit
authors.affiliation: 2 INSERM U955, Institut Mondor de Recherche Biomédicale.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Marcos
authors.affiliation: 2 INSERM U955, Institut Mondor de Recherche Biomédicale.
authors.forename: Emilie
authors.initials: E
authors.lastname: Bizard
authors.affiliation: 6 Centre d'Investigation Clinique 1430 et Plateforme de Ressources Biologiques, and.|2 INSERM U955, Institut Mondor de Recherche Biomédicale.
authors.forename: Philippe
authors.initials: P
authors.lastname: Le Corvoisier
authors.affiliation: 8 Service de Pharmacologie Clinique.|7 Unité de Recherche Clinique (URC-Mondor), APHP, Hôpital Henri Mondor, Créteil, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Macquin-Mavier
authors.affiliation: 1 Département de Physiologie-Explorations Fonctionnelles, DHU-ATVB.|2 INSERM U955, Institut Mondor de Recherche Biomédicale.|3 Université Paris Est (UPEC), Faculté de Médecine, Créteil, France; and.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Derumeaux
authors.affiliation: 9 Département de Cardiologie.
authors.forename: Thibaud
authors.initials: T
authors.lastname: Damy
authors.affiliation: 1 Département de Physiologie-Explorations Fonctionnelles, DHU-ATVB.
authors.forename: Xavier
authors.initials: X
authors.lastname: Drouot
authors.affiliation: 1 Département de Physiologie-Explorations Fonctionnelles, DHU-ATVB.
authors.forename: Ala
authors.initials: A
authors.lastname: Covali-Noroc
authors.affiliation: 2 INSERM U955, Institut Mondor de Recherche Biomédicale.|3 Université Paris Est (UPEC), Faculté de Médecine, Créteil, France; and.
authors.forename: Jorge
authors.initials: J
authors.lastname: Boczkowski
authors.affiliation: 7 Unité de Recherche Clinique (URC-Mondor), APHP, Hôpital Henri Mondor, Créteil, France.|2 INSERM U955, Institut Mondor de Recherche Biomédicale.|3 Université Paris Est (UPEC), Faculté de Médecine, Créteil, France; and.|5 IMRB EA7376, Clinical Epidemiology and Aging (CEpiA), Créteil, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Bastuji-Garin
authors.affiliation: 1 Département de Physiologie-Explorations Fonctionnelles, DHU-ATVB.|2 INSERM U955, Institut Mondor de Recherche Biomédicale.|3 Université Paris Est (UPEC), Faculté de Médecine, Créteil, France; and.
authors.forename: Serge
authors.initials: S
authors.lastname: Adnot
mesh_terms: D000328:Adult; D000375:Aging / Q000235:genetics*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005602:France; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D015999:Multivariate Analysis; D017286:Polysomnography; D011446:Prospective Studies; D063177:Pulse Wave Analysis; D012720:Severity of Illness Index; D012891:Sleep Apnea Syndromes / Q000235:genetics* / Q000503:physiopathology*; D059506:Telomere Shortening
keywords: aging; arterial stiffness; obstructive apnea sleep syndrome; telomere length