title: Blood Transfusion is an Independent Risk Factor for Postoperative Serious Infectious Complications After Pancreaticoduodenectomy.
abstract: Blood transfusionhas been considered as a risk factor for postoperative infection after major surgery. However, the relationship between perioperative blood transfusion and the development of serious infections after pancreaticoduodenectomy remains controversial. The purpose of this study was to analyze risk factors associated with postoperative serious infections following pancreaticoduodenectomy.
  
  
  
  We conducted a retrospective study of 212 patients who underwent pancreaticoduodenectomy during past 2 years and assessed the risk factors for serious infectious complications.
  
  
  
  Serious infections developed in 61 patients (29 %) including 47 cases of surgical site infection (SSI), 19 cases of bacteremia, and 13 cases of pneumonia. One patient died of severe septic shock. A multivariate logistic regression analysis of perioperative factors identified that pancreatic fistula (P < 0.01, OR = 9.763) and blood transfusion (P < 0.01, OR = 3.216) were significant risk factors for serious infections. After excluding 46 patients with pancreatic fistula, blood transfusion continued to be an independent risk factor for serious infections (P < 0.01, OR = 5.831).
  
  
  
  Blood transfusion was the strongest independent factor for serious infections after pancreaticoduodenectomy, which should be considered a quality indicator for the performance of pancreaticoduodenectomy.
authors.affiliation: General Surgery Department, Peking Union Medical College Hospital, Chinese Academy of Medical Science, No. 1 Shuaifu Garden, Dongcheng District, 100730, Beijing, China. liyangzhang25@hotmail.com.
authors.forename: Liyang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: General Surgery Department, Peking Union Medical College Hospital, Chinese Academy of Medical Science, No. 1 Shuaifu Garden, Dongcheng District, 100730, Beijing, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Liao
authors.affiliation: General Surgery Department, Peking Union Medical College Hospital, Chinese Academy of Medical Science, No. 1 Shuaifu Garden, Dongcheng District, 100730, Beijing, China.
authors.forename: Taiping
authors.initials: T
authors.lastname: Zhang
authors.affiliation: General Surgery Department, Peking Union Medical College Hospital, Chinese Academy of Medical Science, No. 1 Shuaifu Garden, Dongcheng District, 100730, Beijing, China.
authors.forename: Menghua
authors.initials: M
authors.lastname: Dai
authors.affiliation: General Surgery Department, Peking Union Medical College Hospital, Chinese Academy of Medical Science, No. 1 Shuaifu Garden, Dongcheng District, 100730, Beijing, China.
authors.forename: Yupei
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000453:epidemiology*; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010185:Pancreatic Fistula / Q000150:complications / Q000453:epidemiology*; D016577:Pancreaticoduodenectomy / Q000009:adverse effects*; D011014:Pneumonia / Q000453:epidemiology* / Q000382:microbiology; D012189:Retrospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000209:etiology; D055815:Young Adult