title: The IL4-VNTR P1 Allele, IL4-VNTR P2P2 Genotype, and IL4-VNTR_IL6-174CG P2P1-GG Genotype Are Associated with an Increased Risk of Brucellosis.
abstract: In this study, associations between IL-4, IL-6, and macrophage migration inhibitory factor (MIF) polymorphisms and susceptibility to brucellosis were investigated. Consecutive adult patients with no known treatment against brucellosis and who did not have any other autoimmune and/or chronic disorders, were included in this study (n = 120, Group I). Age and sex-matched controls who had no other autoimmune and/or chronic disorders were also included (n = 120, healthy volunteers, Group II). The IL4_P2P2 genotype, IL4_P1 allele, and IL4_variable number of tandem repeats (VNTR)_IL6-174CG compound genotype were found to be more frequent in the patient group than in control subjects. There were significant differences between the patients and controls with respect to the frequencies of the IL4_P2P2 genotype (77.5% versus 87.5%; p = 0.001; OR, 0.36; 95% confidence interval [CI], 0.21-0.62) and the IL4_P1 allele (12.1% versus 6.7%; p = 0.030; OR, 0.92; CI, 1.02-3.64). The IL4-VNTR_IL6-174CG compound genotype was also present at a significantly higher frequency in the patient group than in control subjects (11.7% versus 4.2%; p = 0.027, OR, 3.04; CI, 1.06-8.68). No statistically significant differences in the frequencies of the IL-6-174, MIF-173, IL-4_P1P1, and IL4_P2P1 genotypes were observed between patients and control subjects. The IL4_VNTR P1 allele, P2P2 genotypes, and IL4-VNTR_IL6-174CG P2P1-GG genotypes are common in southern Turkey, and carriers of these polymorphisms are susceptible to brucellosis.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Samsun Training and Research Hospital.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Gunal
authors.forename: Serbulent
authors.initials: S
authors.lastname: Yigit
authors.forename: Arzu Didem
authors.initials: AD
authors.lastname: Yalcın
authors.forename: Betul
authors.initials: B
authors.lastname: Celik
authors.forename: Sener
authors.initials: S
authors.lastname: Barut
authors.forename: Osman
authors.initials: O
authors.lastname: Demir
authors.forename: Omer
authors.initials: O
authors.lastname: Ates
authors.forename: Fazilet
authors.initials: F
authors.lastname: Duygu
authors.forename: Safak
authors.initials: S
authors.lastname: Kaya
authors.forename: Aydin
authors.initials: A
authors.lastname: Rustemoglu
authors.forename: Ozlem
authors.initials: O
authors.lastname: Sezer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002006:Brucellosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D019746:Intramolecular Oxidoreductases / Q000235:genetics; D008263:Macrophage Migration-Inhibitory Factors / Q000235:genetics; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D014421:Turkey; D055815:Young Adult
chemical_list: D015850:Interleukin-6; D008263:Macrophage Migration-Inhibitory Factors; D015847:Interleukin-4; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human