title: In Vivo Models of Muscle Angiogenesis.
abstract: Angiogenesis is an important determinant of tissue function, from delivery of oxygen and other substrates to removal of waste products, in health and disease (e.g., adaptive or pathological remodelling). The phenotype and functional responses of endothelial cells are conditioned by systemic humoral signals and local environmental factors, including the haemodynamic forces that act upon them. Here we describe some interventions that have been helpful in unraveling the integrative nature of the complex in vivo response, and quantitative assessment of angiogenesis in muscle.
authors.affiliation: School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, UK. s.egginton@leeds.ac.uk.
authors.forename: Stuart
authors.initials: S
authors.lastname: Egginton
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000502:physiology*; D018919:Neovascularization, Physiologic; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D033081:Shear Strength; D013314:Stress, Mechanical
chemical_list: D011224:Prazosin
keywords: Capillary growth; Electrical stimulation; Mice; Muscle strain; Rats; Shear stress; Skeletal muscle; VEGF