title: Association of Serum Uric Acid Levels in Psoriasis: A Systematic Review and Meta-Analysis.
abstract: High levels of serum uric acid (SUAC) are frequently detected in patients with psoriasis. However, the relationship between psoriasis and hyperuricemia remains unknown. Here we conducted a meta-analysis to identify the SUAC levels in subjects with psoriasis and to determine whether there is an associated risk between psoriasis and hyperuricemia.A comprehensive search of the literature from January 1980 to November 2014 across 7 databases (MEDLINE, Embase, Cochrane Central Register, and 4 Chinese databases) was conducted to determine whether there is an associated risk between psoriasis and hyperuricemia.Among the 170 identified reports, 14 observational studies were included in this meta-analysis. We found a significant higher SUAC level (MD 0.68, 95% CI 0.26-1.09; P = 0.002) in patients with psoriasis in Western Europe, but no significant differences were found between the East Asia and India subgroup (MD 1.22, 95% CI -0.13-2.56; P = 0.08) or the Middle East subgroup (MD 0.48, 95% CI -0.49-1.44; P = 0.33). Similar results were obtained from the meta-analysis of SUAC levels in subjects with severe psoriasis.Our meta-analysis showed that the correlation between psoriasis and hyperuricemia was either ethnicity- or region-dependent and that patients with psoriasis in Western Europe were more likely to have hyperuricemia.
authors.affiliation: From the Department of Dermatology (XL, XM, YW, FL, BL), Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Pharmacology and Experimental Therapeutics (XL, HW, RC), Boston University School of Medicine; and Department of Statistics (QY), Boston University School of Public Health, Boston, MA.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Xiao
authors.initials: X
authors.lastname: Miao
authors.forename: Hongshen
authors.initials: H
authors.lastname: Wang
authors.forename: Yifei
authors.initials: Y
authors.lastname: Wang
authors.forename: Fulun
authors.initials: F
authors.lastname: Li
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yang
authors.forename: Rutao
authors.initials: R
authors.lastname: Cui
authors.forename: Bin
authors.initials: B
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D005060:Europe; D005202:Asia, Eastern; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000209:etiology*; D007194:India; D008297:Male; D008875:Middle Aged; D064887:Observational Studies as Topic; D011565:Psoriasis / Q000097:blood* / Q000150:complications; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid