title: The Effect of HMG CoA Reductase Inhibitors on the Progression of Aortic Sclerosis: Review Article.
abstract: The risk factors and pathology for the development and progression of aortic stenosis are similar to those for arterial atherosclerosis. Statin therapy has been hypothesized to delay progression of aortic stenosis, but studies evaluating this hypothesis report conflicting results. We performed a systematic search and review of statin clinical trials of aortic stenosis progression to determine why there are apparent differences in trial results. We identified 137 reports related to clinical trials of statin therapy and aortic stenosis, 14 of which qualified for analysis. Eight of the nine observational studies reported benefit with statin therapy whereas all five randomized controlled trials (RCTs) reported no benefit. We conclude that there is insufficient evidence to recommend statin treatment for patients at risk of aortic stenosis. Treatment in early stages or studies with longer follow-up is required to conclusively evaluate this possibility.
authors.forename: Sarfaraz
authors.initials: S
authors.lastname: Memon
authors.forename: Harsha V
authors.initials: HV
authors.lastname: Ganga
authors.forename: Shihab
authors.initials: S
authors.lastname: Masrur
authors.forename: Paul D
authors.initials: PD
authors.lastname: Thompson
mesh_terms: D001024:Aortic Valve Stenosis / Q000188:drug therapy / Q000503:physiopathology; D002986:Clinical Trials as Topic; D018450:Disease Progression; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors