title: Brain Oxygen Relationship to Cerebral Perfusion Pressure Depends on Tip Location and Time Window: Can Brain O2 Be an Adjunctive Modality for Determining Optimal CPP?
abstract: Controversy exists regarding the brain tissue oxygen (PbtO2) monitor's optimal tip location and what it actually measures. Recent work [2] identified a "PbtO2 change point" (CPPbt), below which PbtO2 displays pressure-passive behavior, showing significant correlation with optimal cerebral perfusion pressure (CPPopt) as defined by the pressure reactivity index (PRx). This would further support the concept of CPPopt [1] as an individualized target. We endeavored to validate these findings and further explore the relationship between PbtO2 and suboptimal CPP. CPPopt can be determined 55 % of the time [1]. It is undetermined whether PbtO2 can be an adjunctive modality for determining CPPopt.
authors.affiliation: Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. sp3291@cumc.columbia.edu.
authors.forename: Soojin
authors.initials: S
authors.lastname: Park
authors.affiliation: Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
authors.forename: Marek
authors.initials: M
authors.lastname: Czosnyka
authors.affiliation: Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Smielewski
mesh_terms: D000328:Adult; D062186:Arterial Pressure; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D000070624:Brain Contusion / Q000000981:diagnostic imaging / Q000378:metabolism*; D000070625:Brain Injuries, Diffuse / Q000000981:diagnostic imaging / Q000378:metabolism*; D000070642:Brain Injuries, Traumatic / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D007427:Intracranial Pressure; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000378:metabolism*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Brain tissue oxygen monitoring; Optimal cerebral perfusion pressure; Physiologic monitoring