title: Pharmacological inhibition of PI3K class III enhances the production of pro- and anti-inflammatory cytokines in dendritic cells stimulated by TLR agonists.
authors.affiliation: Cátedra de Inmunología, Departamento de Biociencias (Facultad de Química) e Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Pittini
authors.affiliation: Cátedra de Inmunología, Departamento de Biociencias (Facultad de Química) e Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Casaravilla
authors.affiliation: Institute of Immunology and Infection Research Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
authors.forename: Judith E
authors.initials: JE
authors.lastname: Allen
authors.affiliation: Cátedra de Inmunología, Departamento de Biociencias (Facultad de Química) e Instituto de Química Biológica (Facultad de Ciencias), Universidad de la República, Montevideo, Uruguay. Electronic address: adiaz@fq.edu.uy.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Díaz
mesh_terms: D000730:Androstadienes / Q000494:pharmacology; D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology*; D002478:Cells, Cultured; D058534:Class I Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D058546:Class III Phosphatidylinositol 3-Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003713:Dendritic Cells / Q000502:physiology*; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D018664:Interleukin-12 / Q000378:metabolism; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D051058:Oncogene Protein v-akt / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D000077191:Wortmannin
chemical_list: D000730:Androstadienes; D008070:Lipopolysaccharides; D016753:Interleukin-10; D018664:Interleukin-12; D058534:Class I Phosphatidylinositol 3-Kinases; D058546:Class III Phosphatidylinositol 3-Kinases; D051058:Oncogene Protein v-akt; D038362:Glycogen Synthase Kinase 3; D000077191:Wortmannin
keywords: Dendritic cells; IL-10; PI3K; Vps34; Wortmannin