title: LC3-associated phagocytosis: a crucial mechanism for antifungal host defence against Aspergillus fumigatus.
abstract: LC3-associated phagocytosis (LAP) is a non-canonical autophagy pathway involved in the maturation of single-membrane phagosomes and subsequent killing of ingested pathogens by phagocytes. This pathway is initiated following recognition of pathogens by pattern recognition receptors and leads to the recruitment of LC3 into the phagosomal membrane. This form of phagocytosis is utilized for the antifungal host defence and is required for an efficient fungal killing. Here, we provide an overview of the LAP pathway and review the role of LAP in anti-Aspergillus host defence, as well as mechanisms induced by Aspergillus that modulate LAP to promote its survival in the host.
authors.affiliation: Department of Internal Medicine, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.|Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
authors.forename: Evelien G G
authors.initials: EG
authors.lastname: Sprenkeler
authors.affiliation: Department of Internal Medicine, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.|Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Gresnigt
authors.affiliation: Department of Internal Medicine, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.|Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
authors.forename: Frank L
authors.initials: FL
authors.lastname: van de Veerdonk
mesh_terms: D000818:Animals; D001228:Aspergillosis / Q000276:immunology / Q000382:microbiology*; D001232:Aspergillus fumigatus / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D007375:Interleukin-1 / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000502:physiology; D019255:NADPH Oxidases / Q000378:metabolism; D010587:Phagocytosis; D015398:Signal Transduction
chemical_list: D007375:Interleukin-1; C477012:MAP1LC3A protein, human; D008869:Microtubule-Associated Proteins; D019255:NADPH Oxidases