title: Prognostic significance of microRNA-10b overexpression in breast cancer: a meta-analysis.
abstract: Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-10b involvement in human breast cancer and analyze the predicting role of miR-10b for survival. We searched, Embase, and Wanfang databases to identify studies on the prognostic role of miR-10b expression in breast cancer. A total of 770 patients from 7 eligible studies were included in the analysis. Pooled risk ratios (RRs) with 95% confidence interval (95%CI) were calculated to estimate the effect. Our results showed that high miR-10b expression in patients with breast cancer was significantly associated with poor disease-free survival (DFS) (RR = 1.53; 95%CI = 1.06-2.21; P = 0.02). However, no significant association between miR-10b and overall survival was found in overall studies. Subgroup analysis indicated that high expression of miR-10b was significantly correlated with DFS in Asia (RR = 2.94; 95%CI = 1.71-5.05). The present meta-analysis demonstrated that high expression of miR-10b might predict poor survival in patients with breast cancer. Larger clinical studies are required to further evaluate the role of miR-10b in clinical practice.
authors.affiliation: Department of Breast and Thyroid Surgery, China-Japan Friendship Hospital, Beijing, China.
authors.forename: N
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Breast and Thyroid Surgery, China-Japan Friendship Hospital, Beijing, China.
authors.forename: P
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Breast and Thyroid Surgery, China-Japan Friendship Hospital, Beijing, China.
authors.forename: L P
authors.initials: LP
authors.lastname: Huang
authors.affiliation: Hospital of Renmin University of China, Beijing, China.
authors.forename: T Z
authors.initials: TZ
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C547183:MIRN10 microRNA, human; D035683:MicroRNAs