title: Systemic injection of the DAD1 antagonist SCH 23390 reduces saccharin seeking in rats.
abstract: Conditioned cues can elicit drug- and sucrose-seeking behaviors that have been shown to depend on dopamine (DA) D1 receptors. If DAD1 receptors are also involved in seeking behavior in general, blocking these receptors should reduce seeking behavior for a non-caloric, non-drug of abuse reinforcer such as saccharin. Forty-six male Long-Evans rats lever pressed for 0.3% saccharin solution 1 h/day for 10 days. A lever response also activated a tone plus a white stimulus light. This compound stimulus lasted for 5 s. After 1 day of forced abstinence, rats received systemic (0, 1, or 10 μg/kg IP; n = 15-16 per group) injections of SCH 23390 15 min prior to extinction testing. Systemic SCH 23390 reduced saccharin seeking evidenced by a significant reduction in active lever responding and a significant reduction in the number of active lever-contingent deliveries of the tone + light cue following pretreatment with 10 μg/kg SCH 23390. The slope of responding across the Test session in this group was also significantly steeper, indicating that SCH 23390 may have reduced the persistence of saccharin seeking. The results indicate that DAD1 receptors are involved in saccharin seeking and generalize the previously demonstrated anti-seeking effects of DAD1 antagonism to a non-caloric, non-drug of abuse reinforcer.
authors.affiliation: Department of Psychology, Doshisha University, Kyoto, Japan. Electronic address: kaoyama@mail.doshisha.ac.jp.
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Aoyama
authors.affiliation: Department of Psychology and Program in Behavioral Neuroscience, Western Washington University, Bellingham, WA, USA.
authors.forename: Jesse
authors.initials: J
authors.lastname: Barnes
authors.affiliation: Department of Psychology and Program in Behavioral Neuroscience, Western Washington University, Bellingham, WA, USA.
authors.forename: Jon
authors.initials: J
authors.lastname: Koerber
authors.affiliation: Department of Psychology and Program in Behavioral Neuroscience, Western Washington University, Bellingham, WA, USA.
authors.forename: Edwin
authors.initials: E
authors.lastname: Glueck
authors.affiliation: Department of Psychology and Program in Behavioral Neuroscience, Western Washington University, Bellingham, WA, USA.
authors.forename: Kylan
authors.initials: K
authors.lastname: Dorsey
authors.affiliation: Department of Psychology and Program in Behavioral Neuroscience, Western Washington University, Bellingham, WA, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Eaton
authors.affiliation: Department of Psychology and Program in Behavioral Neuroscience, Western Washington University, Bellingham, WA, USA.
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Grimm
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000008:administration & dosage* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D001552:Benzazepines / Q000008:administration & dosage* / Q000627:therapeutic use; D003216:Conditioning, Operant; D066249:Craving / Q000187:drug effects; D003463:Cues; D004305:Dose-Response Relationship, Drug; D005108:Extinction, Psychological / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D064306:Non-Nutritive Sweeteners / Q000008:administration & dosage; D050177:Overweight / Q000378:metabolism / Q000517:prevention & control*; D020318:Rats, Long-Evans; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012054:Reinforcement, Psychology; D015203:Reproducibility of Results; D012439:Saccharin / Q000008:administration & dosage
chemical_list: D001067:Appetite Depressants; D001552:Benzazepines; D064306:Non-Nutritive Sweeteners; D017447:Receptors, Dopamine D1; C534628:SCH 23390; D012439:Saccharin
keywords: Addiction; Craving; Dopamine; SCH 23390; Saccharin