title: Modulation of Immune Responses by Particulate Materials.
abstract: Many biomaterials that are in both preclinical and clinical use are particulate in nature and there is a growing appreciation that the physicochemical properties of materials have a significant impact on their efficacy. The ability of particulates to modulate adaptive immune responses has been recognized for the past century but it is only in recent decades that a mechanistic understanding of how particulates can regulate these responses has emerged. It is now clear that particulate characteristics including size, charge, shape and porosity can influence the scale and nature of both the innate and adaptive immune responses. The potential to tailor biomaterials in order to regulate the type of innate immune response induced, offers significant opportunities in terms of designing systems with increased immune-mediated efficacy.
authors.affiliation: Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, D02 PN40, Ireland.|Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) & Advanced Materials Bio-Engineering Research Centre (AMBER), Trinity College Dublin, Dublin 2, D02 PN40, Ireland.
authors.forename: Filipa
authors.initials: F
authors.lastname: Lebre
authors.affiliation: Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, D02 PN40, Ireland.
authors.forename: Claire H
authors.initials: CH
authors.lastname: Hearnden
authors.affiliation: Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin 2, D02 PN40, Ireland.|Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) & Advanced Materials Bio-Engineering Research Centre (AMBER), Trinity College Dublin, Dublin 2, D02 PN40, Ireland.
authors.forename: Ed C
authors.initials: EC
authors.lastname: Lavelle
mesh_terms: D003713:Dendritic Cells; D007113:Immunity, Innate
keywords: adjuvants; biomaterials; dendritic cells; immunity; macrophages; particulates