title: Differential effects of naloxone on rewarding electrical stimulation of the central nucleus of the amygdala and parabrachial complex in a place preference study.
abstract: The central nucleus of the amygdala (CeA) is considered to be involved in different affective, sensory, regulatory, and acquisition processes. This study analyzed whether electrical stimulation of the PB-CeA system induces preferences in a concurrent place preference (cPP) task, as observed after stimulation of the parabrachial-insular cortex (PB-IC) axis. It also examined whether the rewarding effects are naloxone-dependent. The results show that electrical stimulation of the CeA and external lateral parabrachial subnucleus (LPBe) induces consistent preference behaviors in a cPP task. However, subcutaneous administration of an opiate antagonist (naloxone; 4mg/ml/kg) blocked the rewarding effect of the parabrachial stimulation but not that of the amygdala stimulation. These results are interpreted in the context of multiple brain reward systems that appear to differ both anatomically and neurochemically, notably with respect to the opiate system.
authors.affiliation: Department of Psychobiology and Mind, Brain and Behavior Research Center (CIMCYC), Campus of Cartuja, University of Granada, Granada 18071, Spain. Electronic address: adrague@ugr.es.
authors.forename: Antonio D R
authors.initials: AD
authors.lastname: Agüera
authors.affiliation: Department of Psychobiology and Mind, Brain and Behavior Research Center (CIMCYC), Campus of Cartuja, University of Granada, Granada 18071, Spain. Electronic address: raquelgp@ugr.es.
authors.forename: Raquel
authors.initials: R
authors.lastname: García
authors.affiliation: Department of Psychobiology and Mind, Brain and Behavior Research Center (CIMCYC), Campus of Cartuja, University of Granada, Granada 18071, Spain. Electronic address: apuerto@ugr.es.
authors.forename: Amadeo
authors.initials: A
authors.lastname: Puerto
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001703:Biophysics; D066274:Central Amygdaloid Nucleus / Q000187:drug effects* / Q000502:physiology; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology; D004558:Electric Stimulation; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D065823:Parabrachial Nucleus / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012201:Reward; D012646:Self Administration
chemical_list: D009292:Narcotic Antagonists; D009270:Naloxone
keywords: Central amygdala nucleus; Naloxone; Parabrachial complex; Place pReferences; Rewarding electrical stimulation