title: Evaluation of factors associated with failure of tuberculosis treatment under DOTS in northern Islamic Republic of Iran.
abstract: Tuberculosis treatment failure remains a major health problem in many parts of the Islamic Republic of Iran. This study was conducted to identify the risk factors associated with failure of tuberculosis treatment under the DOTS strategy in two cities of Golestan province. A retrospective cohort study in 2012-2013 was conducted on 167 smearpositive tuberculosis patients monitored under DOTS. Demographic, clinical and treatment outcome factors and social determinants of health were recorded for each patient. Multivariate regression analysis found that the strongest predictors of tuberculosis treatment failure were: being infected with other diseases (OR 9.35; 95% CI: 3.01-29.1), male sex (OR 5.03; 95% CI: 1.58-16.1), Turkoman ethnicity (OR 11.0; 95% CI: 2.00-60.1), family history of tuberculosis (OR 0.21; 95% CI: 0.05-0.96) and household size (OR 1.21; 95% CI: 0.99-1.48). Recommendations include better follow-up for patients with other diseases and facilitating access to treatment, especially for Turkoman patients.
authors.affiliation: Department of Health Services Management, Tehran North Branch, Islamic Azad University, Tehran, Islamic Republic of Iran.
authors.forename: Kh Ali
authors.initials: KhA
authors.lastname: Mohammadzadeh
authors.affiliation: Department of Management, Tehran North Branch, Islamic Azad University, Tehran, Islamic Republic of Iran.
authors.forename: A
authors.initials: A
authors.lastname: Ghayoomi
authors.affiliation: Department of Health Services Management, Tehran North Branch, Islamic Azad University, Tehran, Islamic Republic of Iran.
authors.forename: D
authors.initials: D
authors.lastname: Maghsoudloo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D017211:Treatment Failure; D014376:Tuberculosis / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents