title: Anti-diabetic effect of citrus pectin in diabetic rats and potential mechanism via PI3K/Akt signaling pathway.
abstract: This study was performed to investigate the anti-diabetic effect of citrus pectin in type 2 diabetic rats and its potential mechanism of action. The results showed that fasting blood glucose levels were significantly decreased after 4 weeks of citrus pectin administration. Citrus pectin improved glucose tolerance, hepatic glycogen content and blood lipid levels (TG, TC, LDL-c and HDL-c) in diabetic rats. Citrus pectin also significantly reduced insulin resistance, which played an important role in the resulting anti-diabetic effect. Moreover, after the pectin treatment, phosphorylated Akt expression was upregulated and GSK3β expression was downregulated, indicating that the potential anti-diabetic mechanism of citrus pectin might occur through regulation of the PI3K/Akt signaling pathway. Together, these results suggested that citrus pectin could ameliorate type 2 diabetes and potentially be used as an adjuvant treatment.
authors.affiliation: Key Laboratory of Environment Correlative Dietology, Ministry of Education, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
authors.forename: Yanlong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Key Laboratory of Environment Correlative Dietology, Ministry of Education, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
authors.forename: Man
authors.initials: M
authors.lastname: Dong
authors.affiliation: Key Laboratory of Environment Correlative Dietology, Ministry of Education, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
authors.forename: Ziyu
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Key Laboratory of Environment Correlative Dietology, Ministry of Education, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: siyipan@aliyun.com.
authors.forename: Siyi
authors.initials: S
authors.lastname: Pan
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D015870:Gene Expression / Q000187:drug effects; D000071679:Glycogen Synthase Kinase 3 beta / Q000097:blood*; D006801:Humans; D051058:Oncogene Protein v-akt / Q000097:blood*; D010368:Pectins / Q000008:administration & dosage*; D019869:Phosphatidylinositol 3-Kinases / Q000097:blood; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D001786:Blood Glucose; C586814:citrus pectin; D010368:Pectins; D019869:Phosphatidylinositol 3-Kinases; D000071679:Glycogen Synthase Kinase 3 beta; C000605508:Gsk3b protein, rat; D051058:Oncogene Protein v-akt
keywords: Citrus pectin; Insulin signaling pathway; Type 2 diabetes