title: Retrospective evaluation of the administration of 25% human albumin to dogs with protein-losing enteropathy: 21 cases (2003-2013).
abstract: OBJECTIVE
  To describe the administration of 25% human serum albumin (HSA) to dogs diagnosed with idiopathic inflammatory bowel disease (IBD) and protein-losing enteropathy (PLE). The secondary objectives were to report any acute and delayed adverse events and the effect of corticosteroids on the development of these reactions.
  
  
  METHODS
  Retrospective study (2003-2013).
  
  
  METHODS
  Private referral hospital.
  
  
  METHODS
  Twenty-one client owned dogs diagnosed with PLE and idiopathic IBD that received ≥ 1 transfusion of 25% HSA. Dogs were included in the study if they had panhypoproteinemia, serum albumin concentration < 15.0 g/L [< 1.5 g/dL] or extravascular fluid accumulation, idiopathic IBD confirmed on histopathology, and complete medical records.
  
  
  METHODS
  None.
  
  
  RESULTS
  Two of the 21 patients (9.5%) developed signs consistent with an acute reaction; 1 of these dogs was euthanized due to the severity of the reaction. Two patients (9.5%) showed signs consistent with a delayed reaction; 1 of these dogs was euthanized 5 days after the reaction, though it is unclear whether the reaction and the euthanasia were related. Corticosteroid administration did not appear to affect the occurrence of adverse reactions.
  
  
  CONCLUSIONS
  This retrospective study demonstrated that the administration of 25% HSA to dogs with moderate to severe hypoalbuminemia from PLE was associated with occasional acute and delayed adverse events, some of which were severe or fatal.
authors.affiliation: Associated Veterinary Specialists, Bridgeton, MO, 63044.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Loyd
authors.affiliation: Associated Veterinary Specialists, Bridgeton, MO, 63044.
authors.forename: Christine G
authors.initials: CG
authors.lastname: Cocayne
authors.affiliation: Associated Veterinary Specialists, Bridgeton, MO, 63044.
authors.forename: Julie M
authors.initials: JM
authors.lastname: Cridland
authors.affiliation: Department of Evolution and Ecology, University of California, Davis, CA, 95616.
authors.forename: Wayne R
authors.initials: WR
authors.lastname: Hause
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000401:mortality; D004285:Dogs; D005260:Female; D006801:Humans; D008297:Male; D008499:Medical Records; D011504:Protein-Losing Enteropathies / Q000188:drug therapy / Q000662:veterinary*; D012189:Retrospective Studies; D012709:Serum Albumin / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D012709:Serum Albumin
keywords: complications; hypersensitivity; natural colloids