title: Caffeic acid ameliorates colitis in association with increased Akkermansia population in the gut microbiota of mice.
abstract: Emerging evidence shows that dietary agents and phytochemicals contribute to the prevention and treatment of ulcerative colitis (UC). We first reported the effects of dietary caffeic acid (CaA) on murine experimental colitis and on fecal microbiota. Colitis was induced in C57BL/6 mice by administration of 2.5% dextran sulfate sodium (DSS). Mice were fed a control diet or diet with CaA (1 mM). Our results showed that dietary CaA exerted anti-inflammatory effects in DSS colitis mice. Moreover, CaA could significantly suppress the secretion of IL-6, TNFα, and IFNγ and the colonic infiltration of CD3+ T cells, CD177+ neutrophils and F4/80+ macrophages via inhibition of the activation of NF-κB signaling pathway. Analysis of fecal microbiota showed that CaA could restore the reduction of richness and inhibit the increase of the ratio of Firmicute to Bacteroidetes in DSS colitis mice. And CaA could dramatically increase the proportion of the mucin-degrading bacterium Akkermansia in DSS colitis mice. Thus, CaA could ameliorate colonic pathology and inflammation in DSS colitis mice, and it might be associated with a proportional increase in Akkermansia.
authors.affiliation: Department of Hygiene Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Hygiene Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
authors.forename: Xinyue
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Hygiene Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Cao
authors.affiliation: Department of Hygiene Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Hygiene Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Hygiene Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Hygiene Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, P. R. China.
authors.forename: Shoulin
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Hygiene Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002109:Caffeic Acids / Q000494:pharmacology*; D003092:Colitis / Q000139:chemically induced / Q000378:metabolism / Q000382:microbiology / Q000517:prevention & control*; D003106:Colon / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D016207:Cytokines / Q000378:metabolism; D016264:Dextran Sulfate; D004195:Disease Models, Animal; D005243:Feces / Q000382:microbiology; D005260:Female; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D018836:Inflammation Mediators / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008810:Mice, Inbred C57BL; D020556:Neutrophil Infiltration / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D061327:Verrucomicrobia / Q000145:classification / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000893:Anti-Inflammatory Agents; D002109:Caffeic Acids; D016207:Cytokines; D018836:Inflammation Mediators; D016264:Dextran Sulfate; C040048:caffeic acid
keywords: Immune response; Immunity; Immunology and Microbiology Section; NF-κB pathway; caffeic acid; dextran sulfate sodium; fecal microbiota; ulcerative colitis