title: Uncharted Waters: Zebrafish Cancer Models Navigate a Course for Oncogene Discovery.
abstract: Over a decade has elapsed since the first genetically-engineered zebrafish cancer model was described. During this time remarkable progress has been made. Sophisticated genetic tools have been built to generate oncogene expressing cancers and characterize multiple models of solid and blood tumors. These models have led to unique insights into mechanisms of tumor initiation and progression. New drug targets have been identified, particularly through the functional analysis of cancer genomes. Now in the second decade, zebrafish cancer models are poised for even faster growth as they are used in high-throughput genetic analyses to elucidate key mechanisms underlying critical cancer phenotypes.
authors.affiliation: Program in Molecular Medicine and Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA. Craig.Ceol@umassmed.edu.
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Ceol
authors.affiliation: Departments of Surgery and Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA. yah9014@med.cornell.edu.
authors.forename: Yariv
authors.initials: Y
authors.lastname: Houvras
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes; D015027:Zebrafish
keywords: BRAF; Cancer; Ras; Transgenic; Zebrafish; p53