title: Clinical Use of Deferoxamine in Distraction Osteogenesis of Irradiated Bone.
abstract: The deleterious effects of radiotherapy, including hypovascularity and hypocellularity, have made distraction of irradiated bones challenging. Animal studies, however, have demonstrated adjunctive measures such as the administration of deferoxamine to significantly improve bone regeneration across irradiated distraction gaps. In this report, the authors demonstrate, for the first time, enhanced bone formation following deferoxamine application in a patient following distraction of a previously irradiated maxilla. Computed tomography imaging of the pterygomaxillary buttress on the side of administration revealed significantly increased bone area and density relative to the contralateral buttress. This is the first presentation of clinical deferoxamine use to promote bone formation following irradiated bone distraction and highlights the promise for this adjunctive measure to make outcomes after distraction of irradiated bone more reliable.
authors.affiliation: *Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, Stanford, CA †Plastic Surgery Section, University of Michigan, Ann Arbor, MI.
authors.forename: Arash
authors.initials: A
authors.lastname: Momeni
authors.forename: Scott
authors.initials: S
authors.lastname: Rapp
authors.forename: Alexis
authors.initials: A
authors.lastname: Donneys
authors.forename: Steven R
authors.initials: SR
authors.lastname: Buchman
authors.forename: Derrick C
authors.initials: DC
authors.lastname: Wan
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D003676:Deferoxamine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008437:Maxilla / Q000528:radiation effects / Q000601:surgery; D008439:Maxillary Diseases / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D019857:Osteogenesis, Distraction / Q000379:methods*; D011832:Radiation Injuries / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D019572:Retinal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D012175:Retinoblastoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D017262:Siderophores / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D017262:Siderophores; D003676:Deferoxamine