title: Antimicrobial peptides in marine invertebrate health and disease.
abstract: Aquaculture contributes more than one-third of the animal protein from marine sources worldwide. A significant proportion of aquaculture products are derived from marine protostomes that are commonly referred to as 'marine invertebrates'. Among them, penaeid shrimp (Ecdysozosoa, Arthropoda) and bivalve molluscs (Lophotrochozoa, Mollusca) are economically important. Mass rearing of arthropods and molluscs causes problems with pathogens in aquatic ecosystems that are exploited by humans. Remarkably, species of corals (Cnidaria) living in non-exploited ecosystems also suffer from devastating infectious diseases that display intriguing similarities with those affecting farmed animals. Infectious diseases affecting wild and farmed animals that are present in marine environments are predicted to increase in the future. This paper summarizes the role of the main pathogens and their interaction with host immunity, with a specific focus on antimicrobial peptides (AMPs) and pathogen resistance against AMPs. We provide a detailed review of penaeid shrimp AMPs and their role at the interface between the host and its resident/pathogenic microbiota. We also briefly describe the relevance of marine invertebrate AMPs in an applied context.This article is part of the themed issue 'Evolutionary ecology of arthropod antimicrobial peptides'.
authors.affiliation: CNRS, Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France Ifremer, Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France UPVD, Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France ddestoum@ifremer.fr.
authors.forename: Delphine
authors.initials: D
authors.lastname: Destoumieux-Garzón
authors.affiliation: Laboratory of Immunology Applied to Aquaculture, Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina, 88040-900 Florianópolis, Santa Catarina, Brazil.
authors.forename: Rafael Diego
authors.initials: RD
authors.lastname: Rosa
authors.affiliation: Laboratorio de Genética e Inmunología Molecular, Instituto de Biología, Pontificia Universidad Católica de Valparaíso, Avenida Universidad 330, 2373223 Valparaíso, Chile.
authors.forename: Paulina
authors.initials: P
authors.lastname: Schmitt
authors.affiliation: Laboratory of Immunology Applied to Aquaculture, Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina, 88040-900 Florianópolis, Santa Catarina, Brazil.
authors.forename: Cairé
authors.initials: C
authors.lastname: Barreto
authors.affiliation: Ifremer, UMR 241 EIO, LabexCorail, BP 7004, 98719 Taravao, Tahiti, French Polynesia.
authors.forename: Jeremie
authors.initials: J
authors.lastname: Vidal-Dupiol
authors.affiliation: CNRS, Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France Ifremer, Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France UPVD, Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Mitta
authors.affiliation: CNRS, Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France Ifremer, Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France UPVD, Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Gueguen
authors.affiliation: CNRS, Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France Ifremer, Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France UPVD, Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France Université de Montpellier, Interactions Hôtes-Pathogènes-Environnements (IHPE, UMR5244), Place Eugène Bataillon, 34090 Montpellier cedex, France.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Bachère
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000235:genetics* / Q000378:metabolism; D007448:Invertebrates / Q000235:genetics* / Q000382:microbiology* / Q000821:virology; D033561:Penaeidae / Q000235:genetics / Q000382:microbiology / Q000821:virology
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides
keywords: abiotic stress; immune suppression; invertebrate immunity; polymicrobial disease; resistance; vibrio