title: [Association of Insulin Resistance and β Cell Function with Lipid Metabolism in Middle-aged and Elderly Hui and Han Populations].
abstract: OBJECTIVE
  To explore the association of insulin resistance and β cell function with lipid metabolism in middle-aged and elderly Hui and Han populations.
  
  
  METHODS
  A total of 1000 subjects age over 40 years were recruited from five urban communities in Yinchuan and Wuzhong cities of Ningxia. The composition ratio between Hui and Han nationality was 1:2. A questionnaire-based survey was performed. Physical examinations were carried out to measure the height, body mass, waistline, and hipline. The levels of triglyceride (TG), total cholesterol (TC), blood uric acid (BUA), fasting blood glucose and insulin were measured. The boby mass index (BMI), waist-hip ratio (WHR), and secretion related index including insulin resistance index (IR), insulin sensitivity index (IAI), and beta cell function index (HBCI) were calculated.
  
  
  RESULTS
  The BMI, WHR, IAI, HBCI, and the prevalence rate of diabetes in Hui nationality were significantly higher than those in Han nationality (P<0.01). The levels of BUA, fasting blood glucose, TC, and IR in Han nationality were significantly lower than those in Hui nationality (P<0.01). In Hui populations, TG, BMI, WHR, and BUA were positively correlated with IR (r=0.234, r=0.193, r=0.143, and r=0.129, respectively; P<0.01) and were negatively correlated with IAI (r=-0.234, r=-0.193, r=-0.143, r=-0.129, respectively; P<0.01), whereas TC was negatively correlated with HBCI (r=-0.169, P<0.01). In Han populations, TC, TG, BMI, WHR, and BUA were positively correlated with IR (r=0.140, r=0.257, r=0.288, r=0.163, r=0.104, P<0.01) and negatively correlated with IAI (r=-0.140, r=-0.257, r=-0.288, r=-0.163, and r=-0.104, P<0.01), whereas BMI was negatively correlated with HBCI (r=-0.111, P<0.01). After the influential factors such as gender, nationality, and age were adjusted, the TC, TG, BMI, WHR, BUA levels were positively correlated with IR (r=0.109, r=0.256, r=0.253, r=0.139, and r=0.142, P<0.01) and negatively correlated with IAI (r=-0.109, r=-0.256, r=-0.253, r=-0.139, and r=-0.142, P<0.01). TC and BMI were negatively correlated with HBCI (r=-0.113, r=-0.086, P<0.01). TG and BMI were independently associated with IR and IAI (r=0.218, r=0.182, r=-0.218, r=-0.182), while TC and BMI were independently associated with HBCI (r=-0.113, r=-0.086).
  
  
  CONCLUSIONS
  The distributions of TC, TG, BMI, WHR, BUA, IR, IAI, and HBCI differ between Han and Hui populations. The development of insulin resistance is closely related with the increased levels of TC, TG, BMI, WHR, and BUA. However, the HBCI increases with the increased level of TC and BMI. TG and BMI may be related with insulin resistance. Also, TC and BMI may affect the secretion function of β cells.
authors.affiliation: Graduate School of Ningxia Medical University,Yinchuan 750004,China.
authors.forename: Shu-ya
authors.initials: SY
authors.lastname: Li
authors.affiliation: General Hospital of Ningxia Medical University,National Engineering Research Center for Beijing Biochip Technology,Sub-center in NingXia,Yinchuan 750004,China.
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Graduate School of Ningxia Medical University,Yinchuan 750004,China.
authors.forename: Tian-yu
authors.initials: TY
authors.lastname: Yao
authors.affiliation: Graduate School of Ningxia Medical University,Yinchuan 750004,China.
authors.forename: Yu-xuan
authors.initials: YX
authors.lastname: Cheng
authors.affiliation: Graduate School of Ningxia Medical University,Yinchuan 750004,China.
authors.forename: Ya-jie
authors.initials: YJ
authors.lastname: Fan
authors.affiliation: Graduate School of Ningxia Medical University,Yinchuan 750004,China.
authors.forename: Xu-ying
authors.initials: XY
authors.lastname: Liu
authors.affiliation: Graduate School of Ningxia Medical University,Yinchuan 750004,China.
authors.forename: Jin-ling
authors.initials: JL
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics,School of Public Health of Ningxia Medical University,Yinchuan 750004,China.
authors.forename: Lan
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Biostatistics,School of Public Health of Ningxia Medical University,Yinchuan 750004,China.
authors.forename: Zhi-zhong
authors.initials: ZZ
authors.lastname: Wang
authors.affiliation: Health Examination Center,General Hospital of Ningxia Medical University,Yinchuan 750004,China.
authors.forename: Yu-ying
authors.initials: YY
authors.lastname: Ma
authors.affiliation: Health Examination Center,General Hospital of Ningxia Medical University,Yinchuan 750004,China.
authors.forename: Xue-qin
authors.initials: XQ
authors.lastname: Hu
authors.affiliation: Health Examination Center,General Hospital of Ningxia Medical University,Yinchuan 750004,China.
authors.forename: Pan-pan
authors.initials: PP
authors.lastname: Wang
authors.affiliation: General Hospital of Ningxia Medical University,National Engineering Research Center for Beijing Biochip Technology,Sub-center in NingXia,Yinchuan 750004,China.
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Yu
authors.affiliation: General Hospital of Ningxia Medical University,National Engineering Research Center for Beijing Biochip Technology,Sub-center in NingXia,Yinchuan 750004,China.
authors.forename: Rong
authors.initials: R
authors.lastname: Ma
authors.affiliation: General Hospital of Ningxia Medical University,National Engineering Research Center for Beijing Biochip Technology,Sub-center in NingXia,Yinchuan 750004,China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Huang
mesh_terms: D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D005006:Ethnicity; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000166:cytology*; D050356:Lipid Metabolism; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D014527:Uric Acid; D002784:Cholesterol