title: The global burden of pulmonary hypertension in sickle cell disease: a systematic review and meta-analysis.
abstract: Elevated tricuspid regurgitant jet velocity (TRJV) is a surrogate measure of pulmonary hypertension (PH) in persons with sickle cell disease (SCD). We sought to estimate the burden of PH in people living with sickle cell disease based on TRJV. From 2000 to 2015, we searched electronic databases for eligible publications and included 29 studies (n = 5358 persons). We used random effects modeling to determine the pooled estimate of elevated TRJV. The overall pooled prevalence of elevated TRJV was 23.5 %(95 % CI 19.5-27.4) in persons with SCD. The pooled prevalence of elevated TRJV in children and adults with SCD was 20.7 % (95 % CI 15.7--25.6) and 24.4 % (95 % CI 18.4-30.4), respectively. TRJV is prevalent among adults and children with SCD. Our finding support international recommendations that call for screening for PH in SCD patients.
authors.affiliation: Department of Medicine, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria. babamaiyaki2000@yahoo.co.uk.
authors.forename: B M
authors.initials: BM
authors.lastname: Musa
authors.affiliation: Department of Hematology, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.
authors.forename: N A
authors.initials: NA
authors.lastname: Galadanci
authors.affiliation: Institute of Human Virology, University of Maryland, Baltimore, USA.
authors.forename: M
authors.initials: M
authors.lastname: Coker
authors.affiliation: Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine, Nashville, TN, USA.|Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: S
authors.initials: S
authors.lastname: Bussell
authors.affiliation: Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine, Nashville, TN, USA.|Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.|Departments of Family and Community Medicine, Meharry Medical College, Nashville, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Aliyu
mesh_terms: D000328:Adult; D017677:Age Distribution; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000503:physiopathology; D002648:Child; D015150:Echocardiography, Doppler; D016021:Epidemiologic Studies; D006801:Humans; D006976:Hypertension, Pulmonary / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D008955:Models, Cardiovascular; D015995:Prevalence; D014262:Tricuspid Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology
keywords: Africa; Meta-analysis; Pulmonary hypertension; Sickle cell disease; Tricuspid velocity