title: BODIPY-labeled Fluorescent Aptamer Sensors for Turn-on Sensing of Interferon-gamma and Adenine Compounds on Cells.
abstract: An on-cell aptamer sensor has the potential to reveal cell-cell communications by signalling molecules. We attempted to design new fluorescent aptamer sensors for the sensing of IFN-γ and adenine compounds on cells. BODIPY-labeled external quencher-free aptamer sensors have allowed a turn-on detection of the target molecule with improved off/on efficiency.
authors.affiliation: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo.
authors.forename: Akira
authors.initials: A
authors.lastname: Tsuchiya
authors.forename: Siti N
authors.initials: SN
authors.lastname: Hashim
authors.forename: Shoko
authors.initials: S
authors.lastname: Ise
authors.forename: Takafumi
authors.initials: T
authors.lastname: Furuhata
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Kawai
authors.forename: Rie
authors.initials: R
authors.lastname: Wakabayashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Goto
authors.forename: Noriho
authors.initials: N
authors.lastname: Kamiya
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Sando
mesh_terms: D000225:Adenine / Q000032:analysis* / Q000737:chemistry; D052157:Aptamers, Nucleotide / Q000737:chemistry*; D015374:Biosensing Techniques / Q000379:methods*; D001896:Boron Compounds / Q000737:chemistry*; D002478:Cells, Cultured; D005434:Flow Cytometry / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D052157:Aptamers, Nucleotide; D001896:Boron Compounds; D005456:Fluorescent Dyes; D007371:Interferon-gamma; D000225:Adenine