title: Physical, Chemical, and Biological Structures based on ROS-Sensitive Moieties that are Able to Respond to Oxidative Microenvironments.
abstract: Reactive oxygen species (ROS) (H2 O2 , OCl(-) , (•) OH, O2 (-) ) are a family of reactive molecules that are generated intracellularly and are engaged in many biological processes. In physiological concentrations, ROS act as signaling molecules to a number of metabolic pathways; however, in excess they can be harmful to living organisms. Overproduction of ROS has been related to many pathophysiological conditions and a number of studies have been reported in elucidating their mechanism in these conditions. With the aim of harnessing this role, a number of imaging tools and therapeutic compounds have been developed. Here these imaging and therapeutic tools are reviewed and particularly those structures with ROS-sensitivity based on their biomedical applications and their functional groups. There is also a brief discussion about the method of preparation as well as the mechanism of action.
authors.affiliation: Biosciences Building, Center for Research in Medical Devices, National University of Ireland, Galway, Galway, Ireland.
authors.forename: Christos
authors.initials: C
authors.lastname: Tapeinos
authors.affiliation: Biosciences Building, Center for Research in Medical Devices, National University of Ireland, Galway, Galway, Ireland.
authors.forename: Abhay
authors.initials: A
authors.lastname: Pandit
mesh_terms: D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000737:chemistry*
chemical_list: D017382:Reactive Oxygen Species
keywords: H2O2; ROS responsiveness; drug-delivery systems; imaging probes; theranostics