title: Neural circuits underlying mother's voice perception predict social communication abilities in children.
abstract: The human voice is a critical social cue, and listeners are extremely sensitive to the voices in their environment. One of the most salient voices in a child's life is mother's voice: Infants discriminate their mother's voice from the first days of life, and this stimulus is associated with guiding emotional and social function during development. Little is known regarding the functional circuits that are selectively engaged in children by biologically salient voices such as mother's voice or whether this brain activity is related to children's social communication abilities. We used functional MRI to measure brain activity in 24 healthy children (mean age, 10.2 y) while they attended to brief (<1 s) nonsense words produced by their biological mother and two female control voices and explored relationships between speech-evoked neural activity and social function. Compared to female control voices, mother's voice elicited greater activity in primary auditory regions in the midbrain and cortex; voice-selective superior temporal sulcus (STS); the amygdala, which is crucial for processing of affect; nucleus accumbens and orbitofrontal cortex of the reward circuit; anterior insula and cingulate of the salience network; and a subregion of fusiform gyrus associated with face perception. The strength of brain connectivity between voice-selective STS and reward, affective, salience, memory, and face-processing regions during mother's voice perception predicted social communication skills. Our findings provide a novel neurobiological template for investigation of typical social development as well as clinical disorders, such as autism, in which perception of biologically and socially salient voices may be impaired.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305; daa@stanford.edu menon@stanford.edu.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Abrams
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305;
authors.forename: Tianwen
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305;
authors.forename: Paola
authors.initials: P
authors.lastname: Odriozola
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305;
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Cheng
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305;
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Baker
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305;
authors.forename: Aarthi
authors.initials: A
authors.lastname: Padmanabhan
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305;
authors.forename: Srikanth
authors.initials: S
authors.lastname: Ryali
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305;
authors.forename: John
authors.initials: J
authors.lastname: Kochalka
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305;
authors.forename: Carl
authors.initials: C
authors.lastname: Feinstein
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305; Program in Neuroscience, Stanford University School of Medicine, Stanford, CA 94305; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 daa@stanford.edu menon@stanford.edu.
authors.forename: Vinod
authors.initials: V
authors.lastname: Menon
mesh_terms: D001307:Auditory Perception / Q000502:physiology*; D002648:Child; D003142:Communication; D004594:Electrophysiology; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D007223:Infant; D009035:Mothers; D009434:Neural Pathways / Q000502:physiology*; D012919:Social Behavior; D013067:Speech Perception / Q000502:physiology*; D014831:Voice
keywords: auditory; brain; children; reward; voice