title: Behavioural Variant Frontotemporal Dementia with Bilateral Insular Hypometabolism: A Case Report.
abstract: Fronto-Temporal Dementia (FTD) is a cluster of syndromes, characterized by progressive deterioration of cognition, language and/or behavioural changes associated with degeneration of the frontal and temporal lobes. A 53-year-old man was admitted with a history of gradually progressive behavioural disturbances, disinhibition, unprovoked anger outbursts, apathy, disorganised behaviour and impaired self-care. A clinical diagnosis of Fronto temporal Dementia (behavioural variant) was made. Extensive investigations found no abnormality except in FDG-PET scan of the brain which revealed hypo metabolism in bilateral anterior insular region. Insula is an important brain area implicated in emotional awareness and behaviour control. Hypo metabolism in insular region in the absence of any structural neuroimaging findings, in a case of behavioural variant of Fronto-temporal dementia suggest that, it might be one of the earliest neurobiological changes occurring in this disorder.
authors.affiliation: Senior Resident, Department of Psychiatry, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Ananya
authors.initials: A
authors.lastname: Mahapatra
authors.affiliation: Associate Professor, Department of Psychiatry, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Mamta
authors.initials: M
authors.lastname: Sood
authors.affiliation: Senior Resident, Department of Psychiatry, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Roshan
authors.initials: R
authors.lastname: Bhad
authors.affiliation: Professor, Department of Neurology, All India Institute of Medical Sciences , New Delhi, India .
authors.forename: Manjari
authors.initials: M
authors.lastname: Tripathi
keywords: FTD; Neuroimaging; Role of insula