title: Factors Predictive of Visual Outcome 1 Year After Intravitreal Aflibercept Injection for Typical Neovascular Age-Related Macular Degeneration.
abstract: Several factors have been reported to be associated with visual outcomes after intravitreal ranibizumab treatment for neovascular age-related macular degeneration (AMD). In the present study, we investigated the factors associated with visual outcomes after intravitreal aflibercept injection (IAI) for typical neovascular AMD.
  
  
  
  We retrospectively studied the visual changes in 47 eyes of 51 patients with typical neovascular AMD, who had been initially treated with 3 monthly IAI followed by as-needed IAI.
  
  
  
  Mean best-corrected visual acuity (BCVA) improved during the 12-month follow-up period in 40 eyes of 37 patients without reticular pseudodrusen (RPD) in both eyes, whereas it deteriorated in 11 eyes of 10 patients with RPD in either eye. Multiple regression analysis revealed that visual gain at 12 months after the first IAI positively correlated with worse baseline BCVA and thicker baseline subfoveal choroidal thickness (P = 0.018, P = 0.004, respectively), but not with absence of RPD (P = 0.13). Subfoveal choroidal thickness was significantly thinner in eyes with RPD compared with that in eyes without RPD (P = 0.003).
  
  
  
  Visual gain after IAI in eyes with typical neovascular AMD appears to be limited in patients with RPD, which may reflect the poor visual outcome after IAI in eyes with a thinner subfoveal choroid that is seen predominately in patients with RPD.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, University of Yamanashi , Yamanashi, Japan .
authors.forename: Wataru
authors.initials: W
authors.lastname: Kikushima
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, University of Yamanashi , Yamanashi, Japan .
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Sakurada
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, University of Yamanashi , Yamanashi, Japan .
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sugiyama
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, University of Yamanashi , Yamanashi, Japan .
authors.forename: Naohiko
authors.initials: N
authors.lastname: Tanabe
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, University of Yamanashi , Yamanashi, Japan .
authors.forename: Atsuki
authors.initials: A
authors.lastname: Kume
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, University of Yamanashi , Yamanashi, Japan .
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iijima
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D040262:Receptors, Vascular Endothelial Growth Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D057135:Wet Macular Degeneration / Q000188:drug therapy* / Q000473:pathology
chemical_list: D011993:Recombinant Fusion Proteins; C533178:aflibercept; D040262:Receptors, Vascular Endothelial Growth Factor