title: Regeneration of hair cells in the mammalian vestibular system.
abstract: Hair cells regenerate throughout the lifetime of non-mammalian vertebrates, allowing these animals to recover from hearing and balance deficits. Such regeneration does not occur efficiently in humans and other mammals. Thus, balance deficits become permanent and is a common sensory disorder all over the world. Since Forge and Warchol discovered the limited spontaneous regeneration of vestibular hair cells after gentamicininduced damage in mature mammals, significant efforts have been exerted to trace the origin of the limited vestibular regeneration in mammals after hair cell loss. Moreover, recently many strategies have been developed to promote the hair cell regeneration and subsequent functional recovery of the vestibular system, including manipulating the Wnt, Notch and Atoh1. This article provides an overview of the recent advances in hair cell regeneration in mammalian vestibular epithelia. Furthermore, this review highlights the current limitations of hair cell regeneration and provides the possible solutions to regenerate functional hair cells and to partially restore vestibular function.
authors.affiliation: Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China.|Key Laboratory of Hearing Medicine of the National Health and Family Planning Commission, Shanghai, 200031, China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Li
authors.affiliation: Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China.|Key Laboratory of Hearing Medicine of the National Health and Family Planning Commission, Shanghai, 200031, China.
authors.forename: Dan
authors.initials: D
authors.lastname: You
authors.affiliation: Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China.|Key Laboratory of Hearing Medicine of the National Health and Family Planning Commission, Shanghai, 200031, China.|Research Center, Affiliated Eye and ENT Hospital, Fudan University, Shanghai, 200031, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: MOE Key Laboratory of Developmental Genes and Human Disease, State Key Laboratory of Bioelectronics, Institute of Life Sciences, Southeast University, Nanjing, 210096, China. renjiec@seu.edu.cn.|Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. renjiec@seu.edu.cn.
authors.forename: Renjie
authors.initials: R
authors.lastname: Chai
authors.affiliation: Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China. hwli@shmu.edu.cn.|Key Laboratory of Hearing Medicine of the National Health and Family Planning Commission, Shanghai, 200031, China. hwli@shmu.edu.cn.|Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. hwli@shmu.edu.cn.
authors.forename: Huawei
authors.initials: H
authors.lastname: Li
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D049109:Cell Proliferation; D018069:Hair Cells, Vestibular / Q000502:physiology*; D006801:Humans; D051379:Mice; D004856:Postural Balance; D051881:Receptor, Notch1 / Q000235:genetics*; D012038:Regeneration; D060449:Wnt Signaling Pathway
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D051881:Receptor, Notch1; C500942:ATOH1 protein, human; C497761:NOTCH1 protein, human
keywords: Atoh1; Notch; Wnt; hair cell; regeneration; utricle