title: Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population.
abstract: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting 5-7% of reproductive age women worldwide. The aim of our study was to explore the PCOS-related single nucleotide polymorphism (SNP) associations between common genetic variants and PCOS risk in a Han Chinese women population.
  
  
  
  In this case-control study, 285 Chinese Han women aged 28.50±6.858 years with PCOS and 299 controls of a mean age of 32.66±7.018 years were compared. We selected recently published genome-wide association studies (GWAS) which identified several genetic loci in PCOS. All the SNPs were genotyped by Sequenom Mass-ARRAY technology. Associations between the gene and the risk of PCOS were tested using various genetic models by Statistical Package for the Social Sciences and Plink.
  
  
  
  We found that rs705702 in the RAB5B/SUOX was associated with PCOS (odds ratio=1.42; 95% confidence interval=1.08-1.87, p=0.011) and increased the PCOS risk. The genotypic model analysis also showed that rs705702 was associated with PCOS risk.
  
  
  
  Our results suggest that SNPs rs705702 in gene RAB5B/SUOX was associated with PCOS in Han Chinese women.
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.forename: Yi
authors.initials: Y
authors.lastname: Yuan
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.forename: Jingjie
authors.initials: J
authors.lastname: Li
authors.forename: Tian
authors.initials: T
authors.lastname: Feng
authors.forename: Yongri
authors.initials: Y
authors.lastname: Ouyang
authors.affiliation: Northwest University School of Life Sciences, Xi'an, China, Phone: +86-29-88302831 E-mail: tianbojin1973@163.com.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods*; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D050862:Oxidoreductases Acting on Sulfur Group Donors / Q000235:genetics; D011085:Polycystic Ovary Syndrome / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult; D020696:rab5 GTP-Binding Proteins / Q000235:genetics
chemical_list: D050862:Oxidoreductases Acting on Sulfur Group Donors; C503599:SUOX protein, human; C427755:RAB5C protein, human; D020696:rab5 GTP-Binding Proteins