title: Predictive Effect of Preoperative Anemia on Long-Term Survival Outcomes with Non-Muscle Invasive Bladder Cancer.
abstract: BACKGROUND
  Anemia is the most common hematologic abnormality in bladder cancer (BC) patients. We evaluated the impact of preoperative anemia on oncologic outcomes in BC undergoing transurethral resection of a bladder tumor (TURBT) for the first time diagnosis.
  
  
  METHODS
  We retrospectively evaluated the data collected from 639 patients who underwent TURBT between January 2006 and September 2014 in our department. Of these patients, 320 qualified for inclusion in the study. The primary efficacy endpoint was the effect of preoperative anemia status on cancer-specific and overall survival. Independent t-test and chi-square analyses were performed to assess the effects of anemia on oncologic outcomes. Survival was estimated by using the Kaplan-Meier test.
  
  
  RESULTS
  There were 118 (36.9%) and 202 (63.1%) patients in the anemia (Group-1) and non-anemia groups (Group-2), respectively. The median follow-up duration was 68 months. Anemia was associated with decreased overall survival (<0.001). Comparison between cancer-specific survival of two groups did not show any statistically significant difference (p=0.17).
  
  
  CONCLUSIONS
  Preoperative anemia status of BC patients according to World Health Organization classification is associated with decreased overall survival, but not with cancer-specific survival. We think that preoperative hemoglobin levels should be considered in patient counseling and decision-making for additional therapy.
authors.affiliation: 1Department of Urology, Tepecik Education and Research Hospital, Izmir, Turkey E-mail : drmuratakand@yahoo.com.
authors.forename: Orcun
authors.initials: O
authors.lastname: Celik
authors.forename: Murat
authors.initials: M
authors.lastname: Akand
authors.forename: Mehmet Zeynel
authors.initials: MZ
authors.lastname: Keskin
authors.forename: Rahmi Gokhan
authors.initials: RG
authors.lastname: Ekin
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yoldas
authors.forename: Yusuf Ozlem
authors.initials: YO
authors.lastname: Ilbey
mesh_terms: D000740:Anemia / Q000503:physiopathology*; D015653:Cystectomy / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D011300:Preoperative Care; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery