title: Paraneoplastic cerebellar degeneration as a marker of endometrial cancer recurrence.
abstract: An 84-year-old woman developed a cerebellar syndrome having undergone a total abdominal hysterectomy and bilateral salpingo-oophorectomy for endometrial cancer 1 year previously. She was found to be anti-Yo antibody positive and was diagnosed with paraneoplastic cerebellar degeneration (PCD). A subsequent positron emission tomography scan and lymph node biopsy identified recurrence of her endometrial cancer. This case illustrates how PCD can be an indicator of cancer recurrence, underlines the significance of PCD as a prompt to search for underlying malignancy, and highlights the difficulties PCD poses to the clinician in terms of diagnosis and management.
authors.affiliation: Department of General Medicine, Conquest Hospital, St Leonards-On-Sea, UK.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Lie
authors.affiliation: Department of General Medicine, Conquest Hospital, St Leonards-On-Sea, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Morley
authors.affiliation: Department of Neurology, Conquest Hospital, St Leonards-On-Sea, UK.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Chowdhury
mesh_terms: D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D020362:Paraneoplastic Cerebellar Degeneration / Q000209:etiology*; D011379:Prognosis; D021701:Sentinel Lymph Node Biopsy; D017211:Treatment Failure