title: Linking Nucleoporins, Mitosis, and Colon Cancer.
abstract: Suppression of a nuclear pore protein Nup358/RanBP2 is linked to mitotic cell death, but the clinical relevance of this link is unknown. In a recent issue of Cell, Vecchione et al. (2016) show that in approximately 10% of BRAF-like colorectal cancer (CC) patients, Nup358/RanBP2 is critical for survival. Treatment with vinorelbine, a microtubule-depolymerizing drug that inhibits mitosis, might be a potential treatment for these CCs.
authors.affiliation: Cell-Bionomics Research Unit, Innovative Integrated Bio-Research Core, Institute for Frontier Science Initiative, Bio-AFM Frontier Research Center, and Laboratory of Molecular Cellular Biology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. Electronic address: rwong@staff.kanazawa-u.ac.jp.
authors.forename: Richard W
authors.initials: RW
authors.lastname: Wong
authors.affiliation: Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: mdangelo@sbpdiscovery.org.
authors.forename: Maximiliano
authors.initials: M
authors.lastname: D'Angelo
mesh_terms: D003110:Colonic Neoplasms; D006801:Humans; D008870:Microtubules; D008938:Mitosis; D028861:Nuclear Pore Complex Proteins / Q000235:genetics*
chemical_list: D028861:Nuclear Pore Complex Proteins