title: Neoadjuvant chemotherapy for locally advanced cervical cancer.
abstract: Neoadjuvant chemotherapy followed by surgery (NCS) has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy (NAC) used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and this can reduce the number of high risk patients who require postoperative radiation therapy. Many randomized controlled trials (RCTs) have examined the long-term prognosis of NCS compared to primary surgery, but the utility of NCS remains uncertain. The advent of concurrent chemoradiotherapy (CCRT) has markedly improved the outcome of radiotherapy (RT), and CCRT is now used as a standard method in many cases of advanced bulky cervical cancer. NCS gives a better treatment outcome than radiation therapy alone, but it is important to verify that NCS gives a similar or better outcome compared to CCRT.
authors.affiliation: 1Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan;
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwata
authors.affiliation: 1Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan;
authors.forename: Azumi
authors.initials: A
authors.lastname: Miyauchi
authors.affiliation: 1Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan;
authors.forename: Yukako
authors.initials: Y
authors.lastname: Suga
authors.affiliation: 1Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan;
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishio
authors.affiliation: 1Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan;
authors.forename: Masaru
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: 1Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan;
authors.forename: Akiko
authors.initials: A
authors.lastname: Ohno
authors.affiliation: 1Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan;
authors.forename: Nobumaru
authors.initials: N
authors.lastname: Hirao
authors.affiliation: 1Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan;
authors.forename: Tohru
authors.initials: T
authors.lastname: Morisada
authors.affiliation: 1Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan;
authors.forename: Kyoko
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: 1Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan;
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ueyama
authors.affiliation: 2Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
authors.forename: Hidemichi
authors.initials: H
authors.lastname: Watari
authors.affiliation: 1Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan;
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aoki
keywords: Neoadjuvant chemotherapy (NAC); cervical cancer