title: Electrical stimulation of dog pudendal nerve regulates the excitatory pudendal-to-bladder reflex.
abstract: Pudendal nerve plays an important role in urine storage and voiding. Our hypothesis is that a neuroprosthetic device placed in the pudendal nerve trunk can modulate bladder function after suprasacral spinal cord injury. We had confirmed the inhibitory pudendal-to-bladder reflex by stimulating either the branch or the trunk of the pudendal nerve. This study explored the excitatory pudendal-to-bladder reflex in beagle dogs, with intact or injured spinal cord, by electrical stimulation of the pudendal nerve trunk. The optimal stimulation frequency was approximately 15-25 Hz. This excitatory effect was dependent to some extent on the bladder volume. We conclude that stimulation of the pudendal nerve trunk is a promising method to modulate bladder function.
authors.affiliation: Department of Urology, China Rehabilitation Research Center, Beijing, China; School of Rahabilitation Medicine, Capital Medical University, Beijing, China; Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China.
authors.forename: Yan-He
authors.initials: YH
authors.lastname: Ju
authors.affiliation: Department of Urology, China Rehabilitation Research Center, Beijing, China; School of Rahabilitation Medicine, Capital Medical University, Beijing, China; Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China.
authors.forename: Li-Min
authors.identifier: 0000-0002-7092-6576
authors.initials: LM
authors.lastname: Liao
keywords: electrical stimulation; nerve regeneration; neural regeneration; neurogenic bladder; neuromodulation; pudendal nerve; spinal cord injury; urodynamics; voiding reflex