title: In vivo recovery and early half-life of infused factor VIII in haemophilia A.
abstract: Between 1980 and 1994, 169 in vivo recovery studies were performed in one haemophilia centre on casually-recruited outpatients with severe haemophilia A, and 149 early-phase half-life studies were performed on patients scheduled for elective surgery. Average recoveries improved from 80% to 97% of the expected values over the study period. No relationship of recovery to level of product purification was seen. In the disappearance studies, plasma factor VIII levels fell to half the peak levels by 3.25h after infusion, on average.
authors.affiliation: Orthopaedic Hospital, University of Southern California, Los Angeles, California, USA.
authors.forename: C K
authors.initials: CK
authors.lastname: Kasper
keywords: factor VIII; haemophilia