title: Bioreactors and in situ product recovery techniques for acetone-butanol-ethanol fermentation.
abstract: The microbial fermentation process is one of the sustainable and environment-friendly ways to produce 1-butanol and other bio-based chemicals. The success of the fermentation process greatly relies on the choice of bioreactors and the separation methods. In this review, the history and the performance of bioreactors for the acetone-butanol-ethanol (ABE) fermentation is discussed. The subject is then focused on in situ product recovery (ISPR) techniques, particularly for the integrated extraction-gas stripping. The usefulness of this promising hybrid ISPR device is acknowledged by its incorporation with batch, fed-batch and continuous processes to improve the performance of ABE fermentation.
authors.affiliation: Department of Chemical Engineering, National Chung Hsing University, 145 Xingda Road, Taichung 40227, Taiwan.
authors.forename: Si-Yu
authors.initials: SY
authors.lastname: Li
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan.
authors.forename: Chung-Jen
authors.initials: CJ
authors.lastname: Chiang
authors.affiliation: Department of Chemical Engineering, National Chung Hsing University, 145 Xingda Road, Taichung 40227, Taiwan.
authors.forename: I-Ting
authors.initials: IT
authors.lastname: Tseng
authors.affiliation: Department of Chemical Engineering, National Chung Hsing University, 145 Xingda Road, Taichung 40227, Taiwan.
authors.forename: Chi-Ruei
authors.initials: CR
authors.lastname: He
authors.affiliation: Department of Chemical Engineering, Feng Chia University, Taichung 40724, Taiwan Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan Department of Medical Research, China Medical University Hospital, Taichung 40447, Taiwan ypchao@fcu.edu.tw.
authors.forename: Yun-Peng
authors.initials: YP
authors.lastname: Chao
mesh_terms: D020001:1-Butanol / Q000378:metabolism; D000096:Acetone / Q000378:metabolism*; D001419:Bacteria / Q000378:metabolism*; D019149:Bioreactors; D001709:Biotechnology / Q000379:methods; D000440:Butanols / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism*; D005285:Fermentation; D005947:Glucose / Q000378:metabolism
chemical_list: D000440:Butanols; D000096:Acetone; D000431:Ethanol; D020001:1-Butanol; D005947:Glucose
keywords: bioreactors; cell immobilization; in situ product recovery; the integrated extraction-gas stripping process