title: Engineering phosphopeptide-decorated magnetic nanoparticles as efficient photothermal agents for solid tumor therapy.
abstract: Due to the high therapeutic efficiency and minimum damage towards normal tissues, phototherapy has drawn a great deal of attention in recent decades. Herein, we reported the synthesis of novel phosphopeptide-decorated magnetic nanoparticles (peptide-Fe3O4 nanoparticles), and their usages in photothermal therapy against solid tumor. By using a classical coprecipitation method and a facile ligand exchange route, these peptide-Fe3O4 nanoparticles were prepared with inexpensive inhesion. Upon the irradiation of a near-infrared (NIR) light, these nanoagents exhibited great photothermal effect with high photo-stability. In vitro biocompatibility studies of these peptide-Fe3O4 nanoparticles indicated their low cytotoxicity, negligible hemolysis, and no effect on blood coagulation. As expected, 4T1 murine breast cancer cells could be effectively damaged by these light-mediated nanoagents. Significantly, animal experiments demonstrated that these nanoagents held great solid tumor ablation effect with the assistance of a NIR laser irradiation. Additional studies focused on the long-term toxicity of these nanoagents indicated their high bio-compatibility. Thus, these peptide-Fe3O4 nanoparticles could bring more opportunities to a new generation of photothermal agents in the field of biomedicine.
authors.affiliation: Department of Pathology, The Second Hospital of Jilin University, Changchun, China.
authors.forename: Man
authors.initials: M
authors.lastname: Wu
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, Changchun, China.
authors.forename: Qiaoyan
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, Changchun, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, Changchun, China.
authors.forename: Shujun
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, Changchun, China.
authors.forename: Xuehong
authors.initials: X
authors.lastname: Lu
authors.affiliation: Faw General Hospital (The Fourth Hospital of Jilin University), Changchun, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pathology, The Second Hospital of Jilin University, Changchun, China. Electronic address: gaohongwenjlu@163.com.
authors.forename: Hongwen
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, Changchun, China. Electronic address: pingluo1963@sina.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Luo
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D057005:Bioengineering; D002470:Cell Survival / Q000187:drug effects; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D010316:Particle Size; D010748:Phosphopeptides / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D010789:Phototherapy; D013499:Surface Properties; D014407:Tumor Cells, Cultured
chemical_list: D001672:Biocompatible Materials; D058185:Magnetite Nanoparticles; D010748:Phosphopeptides
keywords: Long-term toxicity; Magnetic nanoparticles; Photothermal therapy; Solid tumor