title: [The Analgesic Sparing Effect of Ketamine for Postoperative Pain Management after Pediatric Surgery on the Body Surface].
abstract: BACKGROUND
  It is reported that ketamine, a N-methyl-D-aspertate (NMDA) receptor antagonist, can provide analgesic effect improving postoperative pain management and decrease the supplementary analgesic requirement. We investigated the analgesic sparing effect of ketamine for postoperative pain in children undergoing surgery of body surface.
  
  
  METHODS
  Fifty eight patients (0-9 yrs) who had surgery of body surface were divided into two groups (ketamine : n = 27, Group K or control : n = 31, Group N). Postoperative analgesia extracted from charts was retrospectively evaluated by the times patients used analgesics until discharge after the operations. Chi-square and Mann-Whitney U tests were used for statistical analysis. Results : The ketamine group received an intrave- nous bolus of ketamine (1 mg - kg-1) before surgical skin incision. However, there were no significant differ- ences of usage (Group K vs Group N : 4/27 vs 7/31, P=0.45) and frequency of supplementary analgesic us- ages (P=0.85) among groups. In addition, there were also no significant demographic differences between the two groups. Conclusions : Our investigation suggests that the intravenous bolus of ketamine (1 mg - kg-1) before surgical skin incision does not decrease the supple- mentary analgesic requirements on postoperative pain management in pediatric surgery of the body surface.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Urabe
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Nakanuno
authors.forename: Kazuma
authors.initials: K
authors.lastname: Hayase
authors.forename: Shogo
authors.initials: S
authors.lastname: Sasada
authors.forename: Reimi
authors.initials: R
authors.lastname: Iwamitsu
authors.forename: Masaki
authors.initials: M
authors.lastname: Senami
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007649:Ketamine / Q000627:therapeutic use*; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D000700:Analgesics; D018691:Excitatory Amino Acid Antagonists; D007649:Ketamine