title: Delayed Graft Function in Kidney Transplantation: Risk Factors and Impact on Early Graft Function.
abstract: BACKGROUND
  Although kidney transplantations are routinely performed at many centers in Turkey, the incidence and risk factors associated with delayed graft function (DGF) here have not yet been well defined.
  
  
  OBJECTIVE
  The aim of this study is to evaluate the incidence and risk factors of DGF and its impact on early graft function.
  
  
  METHODS
  The medical charts of 154 adult patients who underwent deceased donor kidney transplantation between 2000 and 2014 in a single center were reviewed retrospectively.
  
  
  METHODS
  Delayed graft function-related risk factors for donors, recipients, and the transplant surgery itself were analyzed, and their relation with graft function was evaluated.
  
  
  METHODS
  The median recipient age was 39 years. The median cold ischemia time (CIT) was 840 minutes (14 hours). The incidence of DGF and acute rejection were 57.8% and 8.4%, respectively. Higher serum creatinine levels at 3, 6, and 12 months were observed in patients with DGF compared to other patients without DGF (P < .05). Patients with DGF had poor graft function (glomerular filtration rate ≤ 50) at 3 and 6 months (P < .05), but these correlations were not seen at 12 months (P = not significant).
  
  
  RESULTS
  This study showed that DGF was a common and serious problem associated with poor graft functions at 3, 6, and 12 months after transplantation. Extra effort to shorten CIT as an independent risk factor for DGF could have protective effect on graft functions.
authors.affiliation: Tepecik Training and Research Hospital, Department of Transplantation and General Surgery, Izmir, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Tugmen
authors.affiliation: Tepecik Training and Research Hospital, Department of Transplantation and General Surgery, Izmir, Turkey drismailsertege@yahoo.com.
authors.forename: Ismail
authors.initials: I
authors.lastname: Sert
authors.affiliation: Tepecik Training and Research Hospital, Department of Transplantation and General Surgery, Izmir, Turkey.
authors.forename: Eyup
authors.initials: E
authors.lastname: Kebabcı
authors.affiliation: Tepecik Training and Research Hospital, Department of Transplantation and General Surgery, Izmir, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Murat Dogan
authors.affiliation: Tepecik Training and Research Hospital, Department of Nephrology, Izmir, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tanrısev
authors.affiliation: Tepecik Training and Research Hospital, Department of Pediatric Nephrology, Izmir, Turkey.
authors.forename: Caner
authors.initials: C
authors.lastname: Alparslan
authors.affiliation: Katip Celebi University, School of Medicine, Department of Medical Biology, Izmir, Turkey Tepecik Training and Research Hospital, Department of Immunology, Izmir, Turkey.
authors.forename: Tulay
authors.initials: T
authors.lastname: Kılıcaslan Ayna
authors.affiliation: Tepecik Training and Research Hospital, Department of Transplantation and General Surgery, Izmir, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Olmez
authors.affiliation: Tepecik Training and Research Hospital, Department of Transplantation and General Surgery, Izmir, Turkey.
authors.forename: Cezmi
authors.initials: C
authors.lastname: Karaca
mesh_terms: D000208:Acute Disease; D000328:Adult; D000740:Anemia / Q000097:blood / Q000453:epidemiology*; D050377:Cold Ischemia / Q000706:statistics & numerical data*; D003404:Creatinine / Q000097:blood; D051799:Delayed Graft Function / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006084:Graft Rejection / Q000097:blood / Q000453:epidemiology* / Q000517:prevention & control; D006680:HLA Antigens; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology
chemical_list: D006680:HLA Antigens; D006454:Hemoglobins; D007166:Immunosuppressive Agents; D003404:Creatinine
keywords: cold ischemia time; delayed graft function; glomerular filtration rate; graft function; incidence; risk factors; serum creatinine