title: Insights into the use of gadolinium and gadolinium/boron-based agents in imaging-guided neutron capture therapy applications.
abstract: Gadolinium neutron capture therapy (Gd-NCT) is currently under development as an alternative approach for cancer therapy. All of the clinical experience to date with NCT is done with (10)B, known as boron neutron capture therapy (BNCT), a binary treatment combining neutron irradiation with the delivery of boron-containing compounds to tumors. Currently, the use of Gd for NCT has been getting more attention because of its highest neutron cross-section. Although Gd-NCT was first proposed many years ago, its development has suffered due to lack of appropriate tumor-selective Gd agents. This review aims to highlight the recent advances for the design, synthesis and biological testing of new Gd- and B-Gd-containing compounds with the task of finding the best systems able to improve the NCT clinical outcome.
authors.affiliation: Department of Chemistry, University of Torino, Torino, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Deagostino
authors.affiliation: Department of Physics, University of Pavia, Pavia, Italy.|Nuclear Physics National Institute (INFN), Unit of Pavia, Pavia, Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Protti
authors.affiliation: Department of Molecular Biotechnology & Health Sciences, University of Torino, Torino, Italy.
authors.forename: Diego
authors.initials: D
authors.lastname: Alberti
authors.affiliation: Department of Chemistry, University of Torino, Torino, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Boggio
authors.affiliation: Department of Physics, University of Pavia, Pavia, Italy.|Nuclear Physics National Institute (INFN), Unit of Pavia, Pavia, Italy.
authors.forename: Silva
authors.initials: S
authors.lastname: Bortolussi
authors.affiliation: Department of Physics, University of Pavia, Pavia, Italy.|Nuclear Physics National Institute (INFN), Unit of Pavia, Pavia, Italy.
authors.forename: Saverio
authors.initials: S
authors.lastname: Altieri
authors.affiliation: Department of Molecular Biotechnology & Health Sciences, University of Torino, Torino, Italy.
authors.forename: Simonetta Geninatti
authors.initials: SG
authors.lastname: Crich
mesh_terms: D001895:Boron / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005682:Gadolinium / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D017247:Neutron Capture Therapy / Q000379:methods*
chemical_list: D005682:Gadolinium; D001895:Boron
keywords: Gd contrast agents; MRI; boron neutron capture therapy; gadolinium neutron capture therapy; nanosized Gd agents; tumor treatment