title: Early effects of Roux-en-Y gastric bypass on peptides and hormones involved in the control of energy balance.
abstract: BACKGROUND
  Body weight varies depending on the prevailing direction of environmental pressures; however, physiological factors also play a significant role in the control of body weight. The aim of the present study was to assess the impact of Roux-en-Y gastric bypass (RYGB) on hormones and peptides involved in the control of energy balance and their possible implications in appetite/satiety.
  
  
  METHODS
  The sample included 39 individuals with extreme obesity (37 women and two men) who underwent RYGB. Anthropometric and biochemical markers were collected before surgery and 6 months after RYGB.
  
  
  RESULTS
  The BMI decreased from 44.3±6.4 to 31.7±5.7 kg/m (P<0.001) at the sixth month. Percentage of excess weight lost was 63.2±25.0%. Leptin and glucose levels decreased significantly 6 months after RYGB (P<0.001). Interestingly, a significant correlation was confirmed between the anorexigenic gut hormone peptide YY (PYY) and the central anorexigenic mediator α-melanocyte-stimulating hormone after 6 months of RYGB (r=0.35, P=0.004). In contrast, PYY concentrations were correlated negatively with BMI (r=-0.34, P=0.002).
  
  
  CONCLUSIONS
  In the present investigation, it was found that there is a relationship between α-melanocyte-stimulating hormone and PYY concentrations, and it supports the role of the PYY to POMC signal in appetite regulation after RYGB.
authors.affiliation: aPost Graduate Program of Nutrition, Universidade Federal de São Paulo - Escola Paulista de Medicina - UNIFESP-EPM, São Paulo, São Paulo bBariatric Surgery Service cBiochemistry Section, Hospital de Clínicas dDepartment of Nutrition eGraduation in Nutrition, Federal University of Paraná - UFPR, Curitiba, Paraná, Brazil fDepartment of Food Science and Nutrition, University of Minnesota - Twin Cities, Minneapolis, Minnesota, USA.
authors.forename: Bárbara Dal
authors.initials: BD
authors.lastname: Molin Netto
authors.forename: Carrie P
authors.initials: CP
authors.lastname: Earthman
authors.forename: Solange
authors.initials: S
authors.lastname: Cravo Bettini
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Grotti Clemente
authors.forename: Deborah Cristina
authors.initials: DC
authors.lastname: Landi Masquio
authors.forename: Gisele
authors.initials: G
authors.lastname: Farias
authors.forename: Katia
authors.initials: K
authors.lastname: Boritza
authors.forename: Larissa Gabrielle
authors.initials: LG
authors.lastname: da Silva
authors.forename: Maria Emilia
authors.initials: ME
authors.lastname: von der Heyde
authors.forename: Ana Raimunda
authors.initials: AR
authors.lastname: Dâmaso
mesh_terms: D000328:Adult; D001069:Appetite Regulation; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D004734:Energy Metabolism; D015390:Gastric Bypass; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000503:physiopathology / Q000523:psychology / Q000601:surgery*; D036361:Peptide Hormones / Q000097:blood*; D019894:Peptide YY / Q000097:blood; D013270:Stomach / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss; D055815:Young Adult; D000521:alpha-MSH / Q000097:blood
chemical_list: D001786:Blood Glucose; D020738:Leptin; D036361:Peptide Hormones; D019894:Peptide YY; D000521:alpha-MSH