title: A feasibility study for producing an egg matrix candidate reference material for the polyether ionophore salinomycin.
abstract: The aim of this work was to study the feasibility of producing an egg matrix candidate reference material for salinomycin. Preservation techniques investigated were freeze-drying and spray drying dehydration. Homogeneity and stability studies of the produced batches were conducted according to ISO Guides 34 and 35. The results showed that all produced batches were homogeneous and both freeze-drying and spray drying techniques were suitable for matrix dehydrating, ensuring the material stability. In order to preserve the material integrity, it must be transported within the temperature range of -20 up to 25°C. The results constitute an important step towards the development of an egg matrix reference material for salinomycin is possible.
authors.affiliation: National Institute for Quality Control in Health/Oswaldo Cruz Foundation (INCQS/FIOCRUZ), Av. Brasil 4365, Manguinhos, Rio de Janeiro, RJ, Brazil. Electronic address: rosana.ferreira@incqs.fiocruz.br.
authors.forename: Rosana Gomes
authors.initials: RG
authors.lastname: Ferreira
authors.affiliation: National Institute for Quality Control in Health/Oswaldo Cruz Foundation (INCQS/FIOCRUZ), Av. Brasil 4365, Manguinhos, Rio de Janeiro, RJ, Brazil.
authors.forename: Mychelle Alves
authors.initials: MA
authors.lastname: Monteiro
authors.affiliation: National Institute for Quality Control in Health/Oswaldo Cruz Foundation (INCQS/FIOCRUZ), Av. Brasil 4365, Manguinhos, Rio de Janeiro, RJ, Brazil.
authors.forename: Mararlene Ulberg
authors.initials: MU
authors.lastname: Pereira
authors.affiliation: National Institute for Quality Control in Health/Oswaldo Cruz Foundation (INCQS/FIOCRUZ), Av. Brasil 4365, Manguinhos, Rio de Janeiro, RJ, Brazil.
authors.forename: Rafaela Pinto
authors.initials: RP
authors.lastname: da Costa
authors.affiliation: National Institute for Quality Control in Health/Oswaldo Cruz Foundation (INCQS/FIOCRUZ), Av. Brasil 4365, Manguinhos, Rio de Janeiro, RJ, Brazil.
authors.forename: Bernardete Ferraz
authors.initials: BF
authors.lastname: Spisso
authors.affiliation: Chemistry School, Federal University of Rio de Janeiro (UFRJ), Av. Horácio Macedo 2030, Technology Centre, University City, Rio de Janeiro, RJ, Brazil.
authors.forename: Veronica
authors.initials: V
authors.lastname: Calado
mesh_terms: D000068:Accreditation; D000383:Agriculture / Q000592:standards*; D000818:Animals; D002645:Chickens; D004531:Eggs; D004986:Ether / Q000737:chemistry*; D005240:Feasibility Studies; D005612:Freeze Drying; D007476:Ionophores / Q000737:chemistry* / Q000494:pharmacology; D011714:Pyrans / Q000737:chemistry* / Q000494:pharmacology; D012015:Reference Standards; D000095662:Polyether Polyketides
chemical_list: D004986:Ether; D007476:Ionophores; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides
keywords: Coccidiostats; Egg; Polyether ionophore; Reference materials; Salinomycin; Veterinary drug residues