title: Digging for known genetic mutations underlying inherited bone and cartilage characteristics and disorders in the dog and cat.
abstract: Gene mapping projects for many traits in both dogs and cats have yielded new knowledge. Both researchers and the public alike have been fascinated by the inheritance of breed characteristic phenotypes and sporadic disorders. It has been proposed that selective breeding practices have on occasion generated alterations in structure that might be harmful. In this review, simply inherited disorders and characteristics affecting bone and cartilage for which a putative mutation is known are collected. A better understanding of the known inherited basis of skeletal conditions and disorders will assist veterinarians to improve their diagnoses and increase their effectiveness on advising clients on the prevention, management, prognosis and possible treatment of the conditions.
authors.forename: Bianca
authors.initials: B
authors.lastname: Haase
authors.forename: Hamutal
authors.initials: H
authors.lastname: Mazrier
authors.affiliation: Prof. Claire M. Wade, School of Life and Environmental Sciences, Faculty of Veterinary Science, University of Sydney, Regimental Drive, B19-301 RMC Gunn, Sydney, NSW 2006, Australia, Phone +61 29351 8097, Fax +61 29351 3957, E-mail: Claire.Wade@sydney.edu.au.
authors.forename: Claire M
authors.initials: CM
authors.lastname: Wade
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000235:genetics / Q000662:veterinary*; D002357:Cartilage Diseases / Q000235:genetics / Q000662:veterinary*; D002371:Cat Diseases / Q000235:genetics*; D002415:Cats; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs
keywords: Canine; bone; cartilage; feline; gene; genetic mutation; inherited disorders