title: SnAP-eX Reagents for the Synthesis of Exocyclic 3-Amino- and 3-Alkoxypyrrolidines and Piperidines from Aldehydes.
abstract: SnAP-eX (tin amine protocol, exocyclic heteroatoms) reagents allow the single-step transformation of aldehydes and ketones into 2,3-disubstituted pyrrolidines and piperidines containing exocyclic amine or alkoxy groups. These saturated N-heterocycles are of importance in modern drug discovery approaches and are prepared in moderate yields using an operationally simple protocol that is compatible with a range of functional groups and heterocyclic aldehydes.
authors.affiliation: Laboratorium für Organische Chemie, ETH Zürich , HCI F 315, Vladimir Prelog Weg 3, 8093 Zürich, Switzerland.
authors.forename: Michael U
authors.initials: MU
authors.lastname: Luescher
authors.affiliation: Laboratorium für Organische Chemie, ETH Zürich , HCI F 315, Vladimir Prelog Weg 3, 8093 Zürich, Switzerland.
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Bode