title: A Novel Association of the Suppressor of Cytokine Signaling 1 (SOCS1) Gene Polymorphisms in Ischemic Stroke Patients.
abstract: Ischemic stroke is a common neurological disease and a leading cause of permanent disability in many countries. Recent studies provide evidence on the role of the suppressor of the cytokine signaling 1 (SOCS1) gene in the development and progression of atherosclerotic lesions. However, few studies have assessed the association between single nucleotide polymorphisms (SNPs) on SOCS1 gene and ischemic stroke. Therefore, the present study aimed to investigate the role of SOCS1 polymorphism in ischemic stroke risk in a northern Chinese Han population. We examined 475 patients with ischemic stroke and 486 normal controls. Three SNPs (rs243327, rs243330, and rs33932899) of SOCS1 gene were determined for TaqMan genotyping assays. We also classified these case samples in depth by complications with hypertension or diabetes and by ischemic stroke subtypes. When adjusting models by multiple factor analysis by logistic regression, then calculated 10,000 permutations were performed for each model to correct the multiple test. Under additive model, the rs243327 was associated with ischemic stroke with hypertension (p = 0.047). Under heterozygous model, the rs33932899 and rs243330 were significantly associated with ischemic stroke subtypes by atherosclerosis (p = 0.038, p = 0.048, respectively). In summary, our data demonstrated for the first time that the polymorphisms of the SOCS1 gene are associated with the risk of ischemic stroke in a northern Chinese Han population, suggesting that SOCS1 gene polymorphisms may play an important role in the pathogenesis of ischemic stroke.
authors.affiliation: Department of Ultrasound, The 2nd Affiliated Hospital of Harbin Medical University, NO. 246, Xuefu Road, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Ultrasound, The 2nd Affiliated Hospital of Harbin Medical University, NO. 246, Xuefu Road, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
authors.forename: Nana
authors.initials: N
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, The 2nd Affiliated Hospital of Harbin Medical University, NO. 246, Xuefu Road, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
authors.forename: Ruyou
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Ultrasound, The 2nd Affiliated Hospital of Harbin Medical University, NO. 246, Xuefu Road, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Ultrasound, The 2nd Affiliated Hospital of Harbin Medical University, NO. 246, Xuefu Road, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Pathology, The 1st Hospital of Harbin, NO. 151, Diduan Road, Daoli District, Harbin, 150081, Heilongjiang, People's Republic of China.
authors.forename: Zongmin
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Ultrasound, The 2nd Affiliated Hospital of Harbin Medical University, NO. 246, Xuefu Road, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Ultrasound, The 2nd Affiliated Hospital of Harbin Medical University, NO. 246, Xuefu Road, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
authors.forename: Wenying
authors.initials: W
authors.lastname: Hou
authors.affiliation: Department of Bioinformatics, Harbin Medical University, NO. 194 Xuefu Road, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
authors.forename: Qianhui
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of Bioinformatics, Harbin Medical University, NO. 194 Xuefu Road, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China.
authors.forename: Hewei
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Ultrasound, The 2nd Affiliated Hospital of Harbin Medical University, NO. 246, Xuefu Road, Nangang District, Harbin, 150081, Heilongjiang, People's Republic of China. litaosun1971@sina.com.cn.
authors.forename: Litao
authors.identifier: http://orcid.org/0000-0003-4823-3957
authors.initials: L
authors.lastname: Sun
mesh_terms: D044466:Asian People; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D020521:Stroke / Q000235:genetics*; D000071222:Suppressor of Cytokine Signaling 1 Protein / Q000235:genetics*
chemical_list: C108944:SOCS1 protein, human; D000071222:Suppressor of Cytokine Signaling 1 Protein
keywords: Association studies; Genetics; Ischemic stroke; SNPs; SOCS1