title: A False-Negative Case of Primary Central Nervous System Lymphoma on 11C-Methionine PET and Intense 18F-FDG Uptake.
abstract: We report a case of a 44-year-old man with neurological symptoms and MRI findings, which were unable to differentiate between glioma and lymphoma. Metabolic characterization by means of PET imaging with F-FDG and C-methionine is proposed to determine the benign or tumor (high- and low-grade) origin of brain lesions. In this case, the MRI lesion corresponded with an inconclusive metabolic pattern of intense F-FDG uptake and no significant C-methionine uptake. Pathological study revealed a false-negative case of C-methionine due to lymphoma.
authors.affiliation: From the PET Unit, CETIR-ERESA, Barcelona, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: García-Garzon
authors.forename: Diego
authors.initials: D
authors.lastname: Villasboas-Rosciolesi
authors.forename: Miguel
authors.initials: M
authors.lastname: Baquero
authors.forename: Pere
authors.initials: P
authors.lastname: Bassa
authors.forename: Marina
authors.initials: M
authors.lastname: Soler
authors.forename: Eduard
authors.initials: E
authors.lastname: Riera
mesh_terms: D000328:Adult; D002250:Carbon Radioisotopes; D016543:Central Nervous System Neoplasms / Q000000981:diagnostic imaging*; D005188:False Negative Reactions; D019788:Fluorodeoxyglucose F18; D005910:Glioma / Q000000981:diagnostic imaging*; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D008715:Methionine; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D008715:Methionine