title: Positron emission tomography (18)F-fluorodeoxyglucose uptake and prognosis in patients with bone and soft tissue sarcoma: A meta-analysis.
abstract: OBJECTIVE
  To investigate the prognostic significance of (18)F-FDG PET imaging in patients with bone and soft tissue sarcoma, a meta-analysis was conducted.
  
  
  METHODS
  Comprehensive literature searches were performed in PubMed, Embase, Web of Science and Cochrane Library. Pooled hazard ratio (HR) values were calculated to assess the correlations of pre-chemotherapy SUV (SUV1), post-chemotherapy SUV (SUV2), SUV Ratio, total lesion glycolysis (TLG) and metabolic tumor volume (MTV) with event-free survival (EFS) and overall survival (OS).
  
  
  RESULTS
  Twenty-three studies with 1261 patients were identified. The combined HRs for EFS were 1.84 (95% CI: 1.54-2.20) for SUV1, 2.92 (95% CI: 2.15-3.97) for SUV2, 1.90 (95% CI: 1.43-2.52) for SUV Ratio, 3.01 (95% CI: 1.36-6.67) for TLG and 2.32 (95% CI: 1.44-3.75) for MTV. The pooled HRs for OS were 1.85 (95% CI: 1.49-2.30) for SUV1, 2.00 (95% CI: 1.39-2.88) for SUV2, 2.20 (95% CI: 1.18-4.10) for SUV Ratio, 6.19 (95% CI: 2.17-17.66) for TLG and 2.67 (95% CI: 1.52-4.68) for MTV. Besides, high SUV1 was found to be significantly associated with higher rate of metastasis (RR 5.55, 95% CI: 2.75-11.18) and local recurrence (RR 1.87 95% CI: 1.28-2.72).
  
  
  CONCLUSIONS
  (18)F-FDG PET parameters of SUV1, SUV2, SUV Ratio, TLG and MTV may have effective prognostic significance for patients with bone and soft tissue sarcoma. (18)F-FDG PET imaging may be a promising tool to help predict survival outcomes of these patients.
authors.affiliation: Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, PR China; Department of Cancer Center, West China Hospital, Sichuan University, Chengdu, PR China. Electronic address: yougale@outlook.com.
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Li
authors.affiliation: College of Computer Science, Sichuan Normal University, Chengdu, PR China.
authors.forename: Y-L
authors.initials: YL
authors.lastname: Dai
authors.affiliation: Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, PR China.
authors.forename: Y-S
authors.initials: YS
authors.lastname: Cheng
authors.affiliation: Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, PR China.
authors.forename: W-B
authors.initials: WB
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, PR China. Electronic address: tuchongqi@outlook.com.
authors.forename: C-Q
authors.initials: CQ
authors.lastname: Tu
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy; D018572:Disease-Free Survival; D019788:Fluorodeoxyglucose F18; D006801:Humans; D000072078:Positron Emission Tomography Computed Tomography; D049268:Positron-Emission Tomography; D011379:Prognosis; D016016:Proportional Hazards Models; D019275:Radiopharmaceuticals; D012509:Sarcoma / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy; D015996:Survival Rate; D047368:Tumor Burden
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: (18)F-FDG PET; Prognosis; Sarcoma; Survival