title: Rhodium-Catalyzed Asymmetric [2 + 2 + 2] Cycloaddition of α,ω-Diynes with Unsymmetrical 1,2-Disubstituted Alkenes.
abstract: It has been established that a cationic rhodium(I)/axially chiral biaryl bisphosphine complex catalyzes the asymmetric [2 + 2 + 2] cycloaddition of α,ω-diynes with electron-rich and unstrained unsymmetrical 1,2-disubstituted alkenes to give chiral multicyclic compounds with good yields and ee values. Interestingly, enantioselectivity highly depends on the structures of α,ω-diynes used presumably due to the presence of two distinct reaction pathways.
authors.affiliation: Department of Chemical Science and Engineering and ‡Department of Chemistry, Tokyo Institute of Technology , O-okayama, Meguro-ku, Tokyo 152-8550, Japan.
authors.forename: Yukimasa
authors.initials: Y
authors.lastname: Aida
authors.affiliation: Department of Chemical Science and Engineering and ‡Department of Chemistry, Tokyo Institute of Technology , O-okayama, Meguro-ku, Tokyo 152-8550, Japan.
authors.forename: Haruki
authors.initials: H
authors.lastname: Sugiyama
authors.affiliation: Department of Chemical Science and Engineering and ‡Department of Chemistry, Tokyo Institute of Technology , O-okayama, Meguro-ku, Tokyo 152-8550, Japan.
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Uekusa
authors.affiliation: Department of Chemical Science and Engineering and ‡Department of Chemistry, Tokyo Institute of Technology , O-okayama, Meguro-ku, Tokyo 152-8550, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Shibata
authors.affiliation: Department of Chemical Science and Engineering and ‡Department of Chemistry, Tokyo Institute of Technology , O-okayama, Meguro-ku, Tokyo 152-8550, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Tanaka