title: Time to reconsider Spitzoid neoplasms?
abstract: BACKGROUND
  Spitzoid neoplasms may pose significant diagnostic problems because in a fraction of them it is quite difficult or impossible to establish if they are benign or malignant lesions. An extraordinarily large number of studies have been made in attempts to solve this problem; regrettably, the histological criteria proposed and the various special sophisticated techniques employed have proven to be ineffective in making this distinction with confidence.
  
  
  OBJECTIVE
  To explore the possible causes for this diagnostic failure and an attempt to identify the source of this problem.
  
  
  METHODS
  A historical and technical analysis of the specialized literature is performed, critically evaluating the main points of this controversial topic.
  
  
  RESULTS
  The reasons for the diagnostic failure in Spitzoid neoplasms are not clear but could be the result of inappropriate conceptual representation. The analysis of available data and a rational review of old and new assumptions and concepts may suggest a different representation for Spitzoid neoplasms: Spitz nevus, atypical Spitz tumor and Spitzoid melanoma, rather than being three different tumors that are difficult or impossible to distinguish with assurance, could be viewed as one unique entity, Spitz tumor (ST). This tumor is a low-grade malignant neoplasm, in which the amount of intrinsic risk is variable, ranging from very low to high (ST1, ST2, ST3), and malignant potential could be estimated.
  
  
  CONCLUSIONS
  The proposed alternative representation of Spitzoid neoplasms as a unique tumor may help in overcoming the difficulty in diagnosis of these tumors.
authors.affiliation: Department of Anatomic Pathology, Dermatopathology Section, SM Annunziata Hospital, AUSL Toscana Centro, Florence, Italy.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Urso
keywords: Spitz nevus; Spitz tumors; Spitzoid melanoma; atypical Spitz tumor; melanoma