title: Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape.
abstract: Cancer, once thought to be caused largely by genetic alterations, is now considered to be a mixed genetic and epigenetic disease. The epigenetic landscape, which is dictated by covalent DNA and histone modifications, is profoundly altered in transformed cells. These abnormalities may arise from mutations in, or altered expression of, chromatin modifiers. Recent reports on the interplay between cellular signalling pathways and chromatin modifications add another layer of complexity to the already complex regulation of the epigenome. In this Review, we discuss these new studies and how the insights they provide can contribute to a better understanding of the molecular pathogenesis of neoplasia.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida 33136, USA.|Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA.
authors.forename: Fan
authors.initials: F
authors.lastname: Liu
authors.affiliation: Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/School of Medicine, Shanghai Jiao Tong University, Shanghai 200031, China.|State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Perna
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida 33136, USA.|Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA.|Department of Internal Medicine, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Nimer
mesh_terms: D002843:Chromatin / Q000378:metabolism; D044127:Epigenesis, Genetic; D006657:Histones / Q000378:metabolism; D006801:Humans; D009857:Oncogenes; D010766:Phosphorylation; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D002843:Chromatin; D006657:Histones; D014157:Transcription Factors