title: Molecular markers in oral lichen planus: A systematic review.
abstract: Oral lichen planus (OLP) is a chronic inflammatory mucosal disease that is usually detected in 0.5-2.2% of the human population. Among these, only 0.5-2.9% of the lesions progress to carcinoma. However, there are no prognostic markers available presently to recognize the increased risk in malignant transformation of the lesions. Selected markers for cell proliferation, adhesion, apoptosis and lymphocytic infiltration were analyzed by immunohistochemistry in addition to static cytometry for DNA content. The concept linking OLP and oral squamous cell carcinoma states that chronic inflammation results in crucial DNA damage, which further progresses to development of carcinoma. Even though in the past decade, enormous information has been accumulated on malignant potential of OLP, its transformation still remains unclear. Hence, the purpose of this article was to review cellular and molecular markers to understand the pathogenesis of OLP and its progression toward malignancy.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Yogita Dental College and Hospital, Khed, Maharashtra, India.
authors.forename: Shitalkumar
authors.initials: S
authors.lastname: Sagari
authors.affiliation: Department of Public Health Dentistry, Government Dental College and Hospital, Jaipur, Rajasthan, India.
authors.forename: Sudhanshu
authors.initials: S
authors.lastname: Sanadhya
authors.affiliation: Department of Prosthodontics, KLE VK Institute of Dental Sciences, Belgaum, Karnataka, India.
authors.forename: Mallikarjun
authors.initials: M
authors.lastname: Doddamani
authors.affiliation: Department of Oral Medicine and Radiology, Jodhpur Dental College General Hospital, Jodhpur, Rajasthan, India.
authors.forename: Rajan
authors.initials: R
authors.lastname: Rajput
keywords: DNA content; Desmocollin-1; E-cadherin; Ki-67; oral lichen planus