title: [Predictive and prognostic factors of preeclampsia: Interest of PlGF and sFLT-1].
abstract: Preeclampsia is characterized by the association of hypertension and a de novo proteinuria in the second half of pregnancy. Currently, obstetrical teams do not have any tool to detect during the first trimester of pregnancy, in low risk population, the patients likely to develop early and severe preeclampsia. On the other hand, there is no diagnostic/prognostic tool in case of strong suspicion of preeclampsia. The Placental Growth Factor (PIGF) and soluble receptor of the Vascular Endothelial Growth Factor (sFlt-1) are respectively two molecules pro- and anti-angiogenic released mainly by the placenta during pregnancy. Numerous experimental and clinical results suggest that an imbalance of pro/anti-angiogenic factors is involved in the pathophysiology of preeclampsia. We selected and analyzed the main studies that have evaluated the predictive, diagnostic and prognostic value of these two biomarkers for preeclampsia.
authors.affiliation: Département de gynécologie-obstétrique, centre hospitalier intercommunal de Créteil, Créteil, France; Fondation PremUP, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Vieillefosse
authors.affiliation: Fondation PremUP, Paris, France; Service d'endocrinologie, CHU Cochin, AP-HP, Paris, France; UMR-S 1139, Inserm, Paris, France; DHU Risques et grossesse, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Guibourdenche
authors.affiliation: UMR-S 1139, Inserm, Paris, France; PRES Sorbonne Paris Cité, université Paris Descartes, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Atallah
authors.affiliation: Département de gynécologie-obstétrique, centre hospitalier intercommunal de Créteil, Créteil, France; Fondation PremUP, Paris, France; CHI Créteil, université Paris Est Créteil, Créteil, France.
authors.forename: B
authors.initials: B
authors.lastname: Haddad
authors.affiliation: Fondation PremUP, Paris, France; UMR-S 1139, Inserm, Paris, France; PRES Sorbonne Paris Cité, université Paris Descartes, Paris, France.
authors.forename: T
authors.initials: T
authors.lastname: Fournier
authors.affiliation: Fondation PremUP, Paris, France; UMR-S 1139, Inserm, Paris, France; DHU Risques et grossesse, Paris, France; Département de gynécologie-obstétrique, maternité de Port-Royal, centre hospitalier universitaire Cochin Broca Hôtel Dieu, groupe hospitalier universitaire Ouest, Assistance publique-Hôpital de Paris, 53, avenue de l'Observatoire, 75014 Paris, France; PRES Sorbonne Paris Cité, université Paris Descartes, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Tsatsaris
authors.affiliation: Fondation PremUP, Paris, France; UMR-S 1139, Inserm, Paris, France; DHU Risques et grossesse, Paris, France; Département de gynécologie-obstétrique, maternité de Port-Royal, centre hospitalier universitaire Cochin Broca Hôtel Dieu, groupe hospitalier universitaire Ouest, Assistance publique-Hôpital de Paris, 53, avenue de l'Observatoire, 75014 Paris, France; PRES Sorbonne Paris Cité, université Paris Descartes, Paris, France. Electronic address: edouard.lecarpentier@wanadoo.fr.
authors.forename: E
authors.initials: E
authors.lastname: Lecarpentier
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D000072483:Placenta Growth Factor / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; C000608036:PGF protein, human; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1
keywords: Angiogenic factors; Biomarkers; Biomarqueurs; Facteurs angiogéniques; Grossesse; PlGF; Placental growth factor; Prediction; Preeclampsia; Prognosis; Prédiction; Prééclampsie; SFlt-1; sFLT-1