title: Down-regulation of miR-664 in cervical cancer is associated with lower overall survival.
abstract: The aim of our study was to explore the clinicopathologic and prognostic significance of microRNA-664 expression in human cervical cancer.
  
  
  
  qRT-PCR was used to determine the expression of miR-664 in cervical cancer tissues. The relationship between miR-664 expression levels in cervical cancer tissues and clinicopathological characteristics was estimated respectively. The survival curves of the patients were determined using the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were performed.
  
  
  
  The expression of miR-664 is downregulated in human cervical cancer tissues when compared to the corresponding noncancerous tissues (p < 0.01). Low miR-664 expression was significantly associated with lymphatic invasion (p = 0.000), distant metastasis (p < 0.000), FIGO stage (p = 0.001), and histological grade (p = 0.008). Kaplan-Meier analysis demonstrated that low levels of miR-664 expression were associated with poorer overall survival (p < 0.001). In the multivariate analysis, low miR-664 expression was an independent prognostic factor for OS (p = 0.005).
  
  
  
  MiR-664 may be a promising biomarker for the detection and prognosis evaluation of cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Rizhao People's Hospital, Rizhao, Shangdong, China. qinliop0@163.com.
authors.forename: Y-X
authors.initials: YX
authors.lastname: Zhang
authors.forename: L-L
authors.initials: LL
authors.lastname: Qin
authors.forename: S-Y
authors.initials: SY
authors.lastname: Yang
mesh_terms: D014408:Biomarkers, Tumor; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D002583:Uterine Cervical Neoplasms
chemical_list: D014408:Biomarkers, Tumor; C000590115:MIRN664 microRNA, human; D035683:MicroRNAs