title: Synthesis and biological evaluation of 3β-androsta-5,8(14),15-trien-17-one derivatives as potential anticancer agents.
abstract: A novel and operationally simple method for highly efficient synthesis of promising anti-cancer 3β-hydroxy-16-arylandrosta-5,8(14),15-trien-17-ones was reported. Compounds were tested for their cytotoxic activities against A549, SKOV3, MKN-45 and MDA-MB-435 cancer cell lines. The preliminary results showed that compounds 5e, g were the most active especially against cancer cell lines tested.
authors.affiliation: School of Chemistry and Chemical Engineering, Yangzhou University, 180 Siwangting Street, Yangzhou 225002, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, Yangzhou University, 180 Siwangting Street, Yangzhou 225002, PR China.
authors.forename: Jinliang
authors.initials: J
authors.lastname: Liu
authors.affiliation: School of Pharmacy, Taizhou Polytechnic College, Taizhou 225300, PR China.
authors.forename: Lizhong
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, Yangzhou University, 180 Siwangting Street, Yangzhou 225002, PR China.
authors.forename: Xushun
authors.initials: X
authors.lastname: Qing
authors.affiliation: School of Chemistry and Chemical Engineering, Yangzhou University, 180 Siwangting Street, Yangzhou 225002, PR China. Electronic address: wangcd@yzu.edu.cn.
authors.forename: Cunde
authors.initials: C
authors.lastname: Wang
mesh_terms: D000072283:A549 Cells; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents
keywords: 3β-Hydroxy-androsta-5,8(14),15-trien-17-one; Anticancer agent; Dehydroepiandrosterone; Suzuki coupling reaction; α,β-Unsaturated ketone