title: Acetohydrazone: A Transient Directing Group for Arylation of Unactivated C(sp(3))-H Bonds.
abstract: A straightforward and efficient method has been developed for the synthesis of 2-benzylbenzaldehyde derivatives from 2-methylbenzaldehyde and iodobenzene via a C(sp(3))-H activation process. In the course of the activation reaction, acetohydrazone is formed between 2-benzylbenzaldehyde and acetohydrazine as a transient directing group. As a new kind of transient directing group, acetohydrazone exhibits a remarkable directing effect to give corresponding products in good to excellent yields.
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology , Shanghai 200237, P. R. of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Ma
authors.affiliation: State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai 201203, P. R. of China.
authors.forename: Min
authors.initials: M
authors.lastname: Lei
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology , Shanghai 200237, P. R. of China.|State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai 201203, P. R. of China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Hu