title: Cutaneous angiosarcoma mimicking xanthoma: a challenging histopathologic diagnosis with important consequences.
abstract: Cutaneous angiosarcoma may show protean histopathologic features. Rare or uncommon variants include epithelioid, clear cell, granular cell, verrucous, pseudolymphomatous and signet-ring cell types. Perhaps the rarest type consists of cutaneous angiosarcoma with xanthomization of neoplastic cells. We report an extraordinary case with almost all neoplastic cells exhibiting a xanthomatous appearance that was studied both histopathologically and immunohistochemically. We discuss the histopathologic differential diagnosis of foamy cell angiosarcoma with other neoplasms that may show similar histopathology.
authors.affiliation: Department of Dermatology, Hospital Universitario de la Princesa, Universidad Autónoma, Madrid, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Llamas-Velasco
authors.affiliation: Dermatopathologie Friedrichshafen, Friedrichshafen, Germany.
authors.forename: Heinz
authors.initials: H
authors.lastname: Kutzner
authors.affiliation: Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Requena
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology; D014973:Xanthomatosis / Q000175:diagnosis* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
keywords: angiosarcoma; foamy cells; immunohistochemistry