title: Diagnostic measure to quantify loss of clinical components in multi-lead electrocardiogram.
abstract: In this Letter, a novel principal component (PC)-based diagnostic measure (PCDM) is proposed to quantify loss of clinical components in the multi-lead electrocardiogram (MECG) signals. The analysis of MECG shows that, the clinical components are captured in few PCs. The proposed diagnostic measure is defined as the sum of weighted percentage root mean square difference (PRD) between the PCs of original and processed MECG signals. The values of the weight depend on the clinical importance of PCs. The PCDM is tested over MECG enhancement and a novel MECG data reduction scheme. The proposed measure is compared with weighted diagnostic distortion, wavelet energy diagnostic distortion and PRD. The qualitative evaluation is performed using Spearman rank-order correlation coefficient (SROCC) and Pearson linear correlation coefficient. The simulation result demonstrates that the PCDM performs better to quantify loss of clinical components in MECG and shows a SROCC value of 0.9686 with subjective measure.
authors.affiliation: Department of Electronics and Electrical Engineering , Indian Institute of Technology Guwahati , Guwahati 781039 , India.
authors.forename: R K
authors.identifier: 0000-0003-2517-3103
authors.initials: RK
authors.lastname: Tripathy
authors.affiliation: Department of Electronics and Electrical Engineering , Indian Institute of Technology Guwahati , Guwahati 781039 , India.
authors.forename: L N
authors.initials: LN
authors.lastname: Sharma
authors.affiliation: Department of Electronics and Electrical Engineering , Indian Institute of Technology Guwahati , Guwahati 781039 , India.
authors.forename: S
authors.initials: S
authors.lastname: Dandapat
keywords: MECG data reduction scheme; MECG enhancement; MECG signals; Pearson linear correlation coefficient; Spearman rank-order correlation coefficient; clinical components; electrocardiography; medical signal processing; multilead electrocardiogram signals; principal component analysis; principal component-based diagnostic measure; wavelet energy diagnostic distortion; weighted diagnostic distortion; weighted percentage root mean square difference