title: The Protective Role of Thiourea on Leuciscus cephalus Exposed to Sublethal Doses of Pendigan 330EC (Pendimethalin) Herbicide.
abstract: The aim of the study was to investigate the protective role of thiourea on the physiological, hematological, biochemical and histopathological parameters of Leuciscus cephalus exposed to sublethal concentration of Pendigan 330 EC herbicide. The animals were divided in four experimental groups (control, animals subjected to 1 ‰ thiourea, animals subjected to 4 × 10(-4) mL/L herbicide and, respectively, animals subjected to 4 × 10(-4) mL/L herbicide and 1 ‰ thiourea). Exposure of European chub to herbicide administered in water for 2 weeks determined installation of pathological changes in the liver and gills tissues. Also, were observed a decrease in the number of white blood cells and oxygen consumption, breathing frequency, and an increase in the number of red blood cells and glycaemia values. Thiourea counteracts the toxic action, describing itself as normal liver parenchyma and normal gills in animals intoxicated with herbicide, without lesion, and a return to normal values of the studied markers.
authors.affiliation: Department of Ecology, Faculty of Science, University of Pitesti, 2 Targu Din Vale Street, 110040, Pitesti, Romania.
authors.forename: Alina
authors.initials: A
authors.lastname: Paunescu
authors.affiliation: Department of Ecology, Faculty of Science, University of Pitesti, 2 Targu Din Vale Street, 110040, Pitesti, Romania.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Zgurschi
authors.affiliation: Department of Ecology, Faculty of Science, University of Pitesti, 2 Targu Din Vale Street, 110040, Pitesti, Romania.
authors.forename: Liliana Cristina
authors.initials: LC
authors.lastname: Soare
authors.affiliation: Department of Ecology, Faculty of Science, University of Pitesti, 2 Targu Din Vale Street, 110040, Pitesti, Romania.
authors.forename: George Mihail
authors.initials: GM
authors.lastname: Man
authors.affiliation: Department of Ecology, Faculty of Science, University of Pitesti, 2 Targu Din Vale Street, 110040, Pitesti, Romania.
authors.forename: Gheorghita
authors.initials: G
authors.lastname: Brinzea
authors.affiliation: National Research and Development Institute for Chemistry and Petrochemistry - ICECHIM, 202 Spl. Independentei, Sect. 6, 060021, Bucharest, Romania.
authors.forename: Radu Claudiu
authors.initials: RC
authors.lastname: Fierascu
authors.affiliation: National Research and Development Institute for Chemistry and Petrochemistry - ICECHIM, 202 Spl. Independentei, Sect. 6, 060021, Bucharest, Romania. dumitriu.irina@yahoo.com.
authors.forename: Irina
authors.initials: I
authors.lastname: Fierascu
authors.affiliation: Department of Ecology, Faculty of Science, University of Pitesti, 2 Targu Din Vale Street, 110040, Pitesti, Romania.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Ponepal
mesh_terms: D000814:Aniline Compounds / Q000633:toxicity*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D003530:Cyprinidae / Q000502:physiology*; D005880:Gills / Q000473:pathology; D006540:Herbicides / Q000633:toxicity*; D008099:Liver / Q000737:chemistry; D020011:Protective Agents / Q000494:pharmacology*; D013890:Thiourea / Q000494:pharmacology*; D059551:Toxicity Tests, Subacute; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity*
chemical_list: D000814:Aniline Compounds; D015415:Biomarkers; D006540:Herbicides; D020011:Protective Agents; D014874:Water Pollutants, Chemical; D013890:Thiourea; C030856:pendimethalin
keywords: Gills histology; Glycaemia; Herbicide; Liver histology; Thiourea