title: Uterine Sarcoma: The Indian Scenario.
abstract: Uterine sarcomas are rare, highly malignant tumours comprising < 1 % of all gynaecologic malignancies. To evaluate clinical presentation, histolopathologic pattern and outcome of uterine sarcomas presenting to a tertiary referral centre over an 8 year period (2004-2012). All histologically proven uterine sarcomas were retrospectively analysed. Clinical presentation, histology, treatment and outcome were analysed. Mean age was 42 years. Predominant histopathology was endometrial stromal sarcoma (n = 13); 9 were low grade, carcinosarcoma (n = 8) and leiomyosarcoma (n = 2). Fourteen patients had Stage I disease, 3 Stage II, 4 Stage III and 2 were Stage IV at presentation. Patients with disease confined to uterus received no adjuvant treatment (61 %). Of these, 11 were endometrial stromal sarcoma (7 were low grade) and 3 were carcinosarcomas. Four patients received adjuvant EBRT following hysterectomy (17 %). Two patients who presented with metastases received palliative chemotherapy. Mean follow-up period was 46 months (0-86 months). Eleven patients (47 %) developed disease recurrence. Seven (30 %) had local recurrence, while 4 (17 %) developed pulmonary metastases. A total of eight patients died and all deaths were within 1 year of recurrence. The only prognostic factor that correlated with survival was the stage of disease at diagnosis.
authors.affiliation: Department of Surgical Oncology, GAAMCH, Kanchipuram, India.
authors.forename: S
authors.initials: S
authors.lastname: Sivakumari
authors.affiliation: Centre for Oncology, Department of Surgical Oncology, GRH, Chennai, India.
authors.forename: R
authors.initials: R
authors.lastname: Rajaraman
authors.affiliation: Centre for Oncology, Department of Surgical Oncology, GRH, Chennai, India.
authors.forename: S
authors.initials: S
authors.lastname: Subbiah
keywords: Carcinosarcoma; Endometrial stromal sarcoma; Gynaecologic cancers; Gynaecologic sarcoma; Leiomyosarcoma; Uterine sarcoma