title: Ionic liquid based polymeric liposomes: A stable and biocompatible soft platform for bioelectrochemistry.
abstract: Polymeric liposomes (denoted as ILs-polysomes) are a biocompatible and conductive nanomaterial, which was first utilised as the electrode material for immobilising and biosensing redox enzyme horseradish peroxide (HRP). The morphology and surface property of IL-polysomes was characterised and systematically compared with unpolymerised ionic liquid based liposomes (denoted as ILs-liposomes). Differing from IL-liposomes, IL-polysomes preserves their original morphology and bilayer membrane structure on glassy carbon (GC) electrodes due to the cross-linking of polymerised lipids, thus exhibiting excellent stability and specific biocompability. Because of the existence of imidazolium ionic liquid moieties on the outer surface, IL-polysomes displays a positive charge in aqueous solution, leading to oppositely charged HRP self-assembling onto the vesicles to form HRP/IL-polysomes/PVA/GC electrodes. Owing to the combined merits of ILs and liposomes, electron transfer between HRP-Fe(III)/Fe(II) redox couples of immobilised enzymes and GC electrodes can be achieved. Therefore, HRP/IL-polysomes/PVA/GC electrodes exhibited good electrocatalytic performance toward the electrocatalysis of H2O2. Accordingly, IL-polysomes could act as an efficient charged platform for the self-assembled redox enzymes to realise direct electrochemistry. IL-polysomes have a promising application in the fabrication of third-generation electrochemical biosensors.
authors.affiliation: College of Chemistry, Liaoning University, Shenyang 110036, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Tian
authors.affiliation: College of Chemistry, Shandong University, Jinan 250100, China.
authors.forename: Jiarui
authors.initials: J
authors.lastname: Xia
authors.affiliation: College of Chemistry and Life Science, Shenyang Normal University, Shenyang 110034, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Liaoning University, Shenyang 110036, China.
authors.forename: Junhui
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Liaoning University, Shenyang 110036, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: College of Chemistry, Liaoning University, Shenyang 110036, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Liaoning University, Shenyang 110036, China.
authors.forename: Lini
authors.initials: L
authors.lastname: Yang
authors.affiliation: College of Chemistry, Liaoning University, Shenyang 110036, China. Electronic address: zhangq@lnu.edu.cn.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Liaoning University, Shenyang 110036, China. Electronic address: lixinxia@lnu.edu.cn.
authors.forename: Lixin
authors.initials: L
authors.lastname: Xia
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D015374:Biosensing Techniques / Q000379:methods*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D004355:Drug Stability; D004563:Electrochemistry; D004566:Electrodes; D005898:Glass / Q000737:chemistry; D006735:Horseradish Peroxidase / Q000737:chemistry / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000032:analysis / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry*; D016014:Linear Models; D008081:Liposomes / Q000737:chemistry*; D055595:Mechanical Phenomena; D049329:Nanostructures / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D052578:Ionic Liquids; D008081:Liposomes; D011108:Polymers; D002244:Carbon; D011142:Polyvinyl Alcohol; D006861:Hydrogen Peroxide; D006735:Horseradish Peroxidase
keywords: Direct electrochemistry; Ionic liquid; Liposomes; Polymerisation; Redox enzyme