title: Ultrastable and Biofunctionalizable Gold Nanoparticles.
abstract: Gold nanoparticles provide an excellent platform for biological and material applications due to their unique physical and chemical properties. However, decreased colloidal stability and formation of irreversible aggregates while freeze-drying nanomaterials limit their use in real world applications. Here, we report a new generation of surface ligands based on a combination of short oligo (ethylene glycol) chains and zwitterions capable of providing nonfouling characteristics while maintaining colloidal stability and functionalization capabilities. Additionally, conjugation of these gold nanoparticles with avidin can help the development of a universal toolkit for further functionalization of nanomaterials.
authors.affiliation: Department of Chemistry, University of Massachusetts-Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
authors.forename: Akash
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Department of Chemistry, University of Massachusetts-Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Moyano
authors.affiliation: Department of Chemistry, University of Massachusetts-Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.|Biological Engineering Program, Faculty of Engineering, King Mongkut's University of Technology Thonburi , Bangmod, Bangkok 10140, Thailand.
authors.forename: Attasith
authors.initials: A
authors.lastname: Parnsubsakul
authors.affiliation: Department of Chemistry, University of Massachusetts-Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
authors.forename: Alexander
authors.initials: A
authors.lastname: Papadopoulos
authors.affiliation: Department of Chemistry, University of Massachusetts-Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Wang
authors.affiliation: Department of Chemistry, University of Massachusetts-Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
authors.forename: Ryan F
authors.initials: RF
authors.lastname: Landis
authors.affiliation: Department of Chemistry, University of Massachusetts-Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
authors.forename: Riddha
authors.initials: R
authors.lastname: Das
authors.affiliation: Department of Chemistry, University of Massachusetts-Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D019855:Ethylene Glycol / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D008024:Ligands; D053768:Metal Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000592:standards
chemical_list: D008024:Ligands; D006046:Gold; D019855:Ethylene Glycol
keywords: DLS; UV; biofluids; freeze-drying; gold nanoparticles; ion strength; stability; surface plasmon resonance