title: Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism.
abstract: Changes in profile of lipids and adipokines have been reported in patients with thyroid dysfunction. But the evidence is controversial. The present study aimed to explore the relationships between thyroid function and the profile of lipids and adipokines. A cross-sectional study was conducted in 197 newly diagnosed hypothyroid patients, 230 newly diagnosed hyperthyroid patients and 355 control subjects. Hypothyroid patients presented with significantly higher serum levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDLC), fasting insulin, resistin and leptin than control (p < 0.05). Hyperthyroid patients presented with significantly lower serum levels of high-density lipoprotein cholesterol, LDLC and leptin, as well as higher levels of fasting insulin, resistin, adiponectin and homeostasis model insulin resistance index (HOMA-IR) than control (p < 0.05). Nonlinear regression and multivariable linear regression models all showed significant associations of resistin or adiponectin with free thyroxine and association of leptin with thyroid-stimulating hormone (p < 0.001). Furthermore, significant correlation between resistin and HOMA-IR was observed in the patients (p < 0.001). Thus, thyroid dysfunction affects the profile of lipids and adipokines. Resistin may serve as a link between thyroid dysfunction and insulin resistance.
authors.affiliation: Department of Geriatrics, the First Affiliated Hospital, China Medical University, Shenyang, Liaoning, P. R. China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Program of Environmental Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P. R. China.
authors.forename: Xiafang
authors.initials: X
authors.lastname: Wu
authors.affiliation: Program of Environmental Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P. R. China.
authors.forename: Ruirui
authors.initials: R
authors.lastname: Wu
authors.affiliation: Department of Occupational and Environmental Health, College of Public Health, Dalian Medical University, Dalian, Liaoning, P. R. China.
authors.forename: Xiance
authors.initials: X
authors.lastname: Sun
authors.affiliation: Environment and Non-communicable Disease Research Center, School of Public Health, China Medical University, Shenyang, Liaoning, P. R. China.
authors.forename: Boyi
authors.initials: B
authors.lastname: Yang
authors.affiliation: Environment and Non-communicable Disease Research Center, School of Public Health, China Medical University, Shenyang, Liaoning, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Program of Environmental Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, P. R. China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Xu
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000473:pathology*; D007037:Hypothyroidism / Q000473:pathology*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D052243:Resistin / Q000378:metabolism*; D044967:Serum / Q000737:chemistry; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D054392:Adipokines; D008055:Lipids; C499624:RETN protein, human; D052243:Resistin; D013972:Thyrotropin; D013974:Thyroxine