title: Type-Specific Identification of Genital Human Papillomavirus Infection in Women with Cytological Abnormality.
abstract: OBJECTIVE
  To estimate the frequency of human papillomavirus (HPV) infection and the genotype distribution of HPV among women with a Pap smear showing atypical squamous cells of undetermined significance (ASC-US) attending the Program for the Detection and Control of Cervical Cancer in Bogotá, Colombia.
  
  
  METHODS
  Cervical samples from 200 women with an ASC-US Pap smear were analyzed for the presence of HPV DNA and genotype distribution using a commercial molecular technique (Linear Array®; Roche Molecular Systems, USA).
  
  
  RESULTS
  HPV infection was found in 140 women (70%). High-risk HPV types were present in 46.4% of the samples; 16.4% showed a low-risk HPV type, and 37.1% showed both. Of the positive samples, 42.9% were infected with a single viral genotype, whereas 57.1% exhibited multiple HPV infections. The most common HPV genotypes were HPV 16, 53, and 52 with a prevalence of 26.4, 16.4, and 13.6%, respectively.
  
  
  CONCLUSIONS
  The epidemiological characterization of HPV infections described in this study might guide actions for epidemiological surveillance to strengthen the program in Bogotá and to develop appropriate HPV vaccination programs.
authors.affiliation: Laboratorio de Salud Pública, Dirección de Epidemiología, Análisis y Gestión de Políticas de Salud Colectiva, Subsecretaria de Salud Pública, Secretaría Distrital de Salud, Bogotá, Colombia.
authors.forename: Hernán
authors.initials: H
authors.lastname: Vargas
authors.forename: Jenny P
authors.initials: JP
authors.lastname: Sánchez
authors.forename: Mónica L
authors.initials: ML
authors.lastname: Guerrero
authors.forename: Leider T
authors.initials: LT
authors.lastname: Ortiz
authors.forename: Dayanne M
authors.initials: DM
authors.lastname: Rodríguez
authors.forename: Jairo
authors.initials: J
authors.lastname: Amaya
authors.forename: Liliana P
authors.initials: LP
authors.lastname: Diaz
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Gómez
authors.forename: Carlos
authors.initials: C
authors.lastname: Golijow
mesh_terms: D000328:Adult; D065309:Atypical Squamous Cells of the Cervix / Q000473:pathology / Q000821:virology; D002584:Cervix Uteri / Q000473:pathology* / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test / Q000379:methods; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000473:pathology* / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology; D014626:Vaginal Smears / Q000379:methods; D055815:Young Adult
chemical_list: D004279:DNA, Viral