title: A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer's disease.
abstract: Alzheimer's disease (AD) is often characterized by vascular pathology, a procoagulant state, and chronic inflammation. The mechanisms behind these abnormalities in AD are not clear. Here, we review evidence for the role of the AD-associated peptide Aβ in promoting inflammation and thrombosis in AD via its interaction with the circulating proteins factor XII and fibrinogen.
authors.affiliation: Laboratory of Neurobiology and Genetics; The Rockefeller University; New York, NY 10065, USA.
authors.forename: Daria
authors.initials: D
authors.lastname: Zamolodchikov
authors.affiliation: Laboratory of Neurobiology and Genetics; The Rockefeller University; New York, NY 10065, USA. Electronic address: strickland@rockefeller.edu.
authors.forename: Sidney
authors.initials: S
authors.lastname: Strickland
mesh_terms: D000544:Alzheimer Disease / Q000097:blood* / Q000150:complications / Q000276:immunology* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000276:immunology*; D000818:Animals; D001777:Blood Coagulation; D005174:Factor XII / Q000276:immunology; D005340:Fibrinogen / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000150:complications / Q000276:immunology* / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; D005174:Factor XII; D005340:Fibrinogen
keywords: Alzheimer's disease; beta-amyloid; contact activation system; factor XII; fibrin(ogen)