title: Screening for type 2 diabetes mellitus in overweight and obese subjects made easy by the FINDRISC score.
abstract: To evaluate the use of the FINDRISC score in an overweight and obese population to predict glucose status.
  
  
  
  In 651 overweight/obese subjects (M/F: 193/458, age 43±13 y, BMI 38.2±6.1kg/m(2)) glucose status was tested using OGTT and HbA1c. Furthermore, the FINDRISC questionnaire and CT visceral fat (VAT) and subcutaneous fat (SAT) were examined.
  
  
  
  Exactly 50.4% were found to have prediabetes and 11.1% were newly diagnosed with type 2 diabetes (T2DM) (M/F=22.2/8.8%). Subjects without T2DM had a FINDRISC score of 11±3, those with pre-DM 13±4, and subjects with de novo T2DM 15±5. The aROC of the FINDRISC for detecting T2DM was 0.76 (95% CI 0.72-0.82), with 13 as cutoff point. The FINDRISC score correlated with VAT (r=0.34, p<0.001) and VAT/SAT ratio (r=0.39, p<0.001). The aROC of the FINDRISC to detect excess VAT was 0.79 (95%CI 0.72-0.84).
  
  
  
  In a large group of overweight and obese subjects, 50.4% were found to have pre-DM and 11.1% were newly diagnosed with T2DM. The FINDRISC score increased with worsening of glucose tolerance status and proved to be an independent predictor of T2DM status, as did HOMA-B, HOMA-S and VAT. The FINDRISC can also function as a good tool to predict visceral obesity.
authors.affiliation: University of Antwerp, Faculty of Medicine and Health Sciences, Antwerp, Belgium; Department of Endocrinology, Diabetology & Metabolism, Antwerp University Hospital, Edegem, Belgium.
authors.forename: A S
authors.initials: AS
authors.lastname: Meijnikman
authors.affiliation: University of Antwerp, Faculty of Medicine and Health Sciences, Antwerp, Belgium; Department of Endocrinology, Diabetology & Metabolism, Antwerp University Hospital, Edegem, Belgium.
authors.forename: C E M
authors.initials: CE
authors.lastname: De Block
authors.affiliation: University of Antwerp, Faculty of Medicine and Health Sciences, Antwerp, Belgium; Department of Endocrinology, Diabetology & Metabolism, Antwerp University Hospital, Edegem, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Verrijken
authors.affiliation: Department of Endocrinology, Diabetology & Metabolism, Antwerp University Hospital, Edegem, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Mertens
authors.affiliation: Department of Radiology, Antwerp University Hospital, Edegem, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Corthouts
authors.affiliation: University of Antwerp, Faculty of Medicine and Health Sciences, Antwerp, Belgium; Department of Endocrinology, Diabetology & Metabolism, Antwerp University Hospital, Edegem, Belgium. Electronic address: luc.van.gaal@uza.be.
authors.forename: L F
authors.initials: LF
authors.lastname: Van Gaal
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis*; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D050177:Overweight / Q000150:complications*; D050151:Subcutaneous Fat
keywords: Cardiovascular risk score; Diabetes risk score; Obesity; Screening; Type 2 diabetes mellitus; Visceral fat accumulation