title: Time interval between surgery and start of adjuvant radiotherapy in patients with soft tissue sarcoma: A retrospective analysis of 1131 cases from the French Sarcoma Group.
abstract: The aim of this study was to evaluate the impact of the time interval (TI) between surgery and adjuvant radiotherapy (RT) in soft tissue sarcoma (STS).
  
  
  
  Data from 1131 patients treated between 1990 and 2014 were retrospectively reviewed. Inclusion criteria were: limb or superficial trunk wall STS (R0 or R1 resection) and adjuvant RT. The impact of TI on 10-year local relapse-free survival (LRFS) and 10-year overall survival (OS) was analyzed using a Log-rank test and then Cox Model.
  
  
  
  The median TI was 82days (range, 18-346). With a median follow-up of 235months (range, 2-296months), the 10-year LRFS was 57.5% (±2%) and the 10-year OS was 64.2% (±2%). With a TI of 19-39days, 40-79days, 80-119days, and ⩾120days, 10-year LRFSs were 65.3%, 55.5%, 56.9% and 61.2% (p=0.465), and 10-year OSs were 72.8%, 60.7%, 66.4% and 62.1% (p=0.347), respectively. After adjustment for the factors significantly (p⩽0.05) associated with LRFS and OS, TI did not alter LRFS (p=0.182) either OS (p=0.335).
  
  
  
  In this retrospective STS database study, the TI between surgery and start of adjuvant RT did not seem to affect outcomes.
authors.affiliation: Department of Radiation Oncology, Centre Oscar Lambret, Lille, France. Electronic address: jacfourquet@gmail.com.
authors.forename: Jacques
authors.initials: J
authors.lastname: Fourquet
authors.affiliation: Department of Radiation Oncology, Centre Léon Bérard, Lyon, France.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Sunyach
authors.affiliation: Department of Radiation Oncology, Institut Bergonié, Bordeaux, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Vilotte
authors.affiliation: Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Le Péchoux
authors.affiliation: Department of Biopathology, Centre Léon Bérard, Lyon, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Ranchère-Vince
authors.affiliation: Department of Surgery, Institut Gustave Roussy, Villejuif, France; Department of Surgery, Institut Curie, Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Bonvalot
authors.affiliation: University of Bordeaux, INSERM U916, Department of Biopathology, Institut Bergonié, Bordeaux, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Coindre
authors.affiliation: Department of Pathology, Institut Gustave Roussy, Villejuif, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Terrier
authors.affiliation: Department of Surgery, Centre Léon Bérard, Lyon, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Meeus
authors.affiliation: Department of Radiation Oncology, Institut Curie, Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Helfre
authors.affiliation: Department of Radiation Oncology, Centre Georges-François Leclerc, Dijon, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Martin
authors.affiliation: Department of Radiation Oncology, Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Vogin
authors.affiliation: Department of Radiation Oncology, Centre Jean Perrin, Clermont-Ferrand, France.
authors.forename: Julian
authors.initials: J
authors.lastname: Biau
authors.affiliation: Department of Radiation Oncology, Centre François Baclesse, Caen, France.
authors.forename: William
authors.initials: W
authors.lastname: Kao
authors.affiliation: Department of Radiation Oncology, Centre Paul Strauss, Strasbourg, France.
authors.forename: Georges
authors.initials: G
authors.lastname: Noel
authors.affiliation: Department of Radiation Oncology, Institut Claudius Regaud, IUCT-Oncopole, Toulouse, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Ducassou
authors.affiliation: Department of Radiation Oncology, Institut du Cancer de Montpellier, France.
authors.forename: Carmen
authors.initials: C
authors.lastname: Llacer-Moscardo
authors.affiliation: Department of Surgery, Institut Bergonié, Bordeaux, France.
authors.forename: Eberhard
authors.initials: E
authors.lastname: Stoeckle
authors.affiliation: Department of Medical Oncology, Centre Oscar Lambret, Lille, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Penel
authors.affiliation: Department of Radiation Oncology, Institut Bergonié, Bordeaux, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Sargos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012509:Sarcoma / Q000532:radiotherapy* / Q000601:surgery; D013997:Time Factors; D055815:Young Adult
keywords: Postoperative radiotherapy; Soft tissue sarcoma; Time interval