title: Hormonal changes after localized prostate cancer treatment. Comparison between external beam radiation therapy and radical prostatectomy.
abstract: OBJECTIVE
  To determine the influence of radical prostatectomy (RP) and external beam radiation therapy (EBRT) on the hypothalamic pituitary axis of 120 men with clinically localized prostate cancer treated with RP or EBRT exclusively.
  
  
  METHODS
  120 patients with localized prostate cancer were enrolled. Ninety two patients underwent RP and 28 patients EBRT exclusively. We measured serum levels of luteinizing hormone, follicle stimulating hormone (FSH), total testosterone (T), free testosterone, and estradiol at baseline and at 3 and 12 months after treatment completion.
  
  
  RESULTS
  Patients undergoing RP were younger and presented a higher prostate volume (64.3 vs. 71.1 years, p<0.0001 and 55.1 vs. 36.5 g, p<0.0001; respectively). No differences regarding serum hormonal levels were found at baseline. Luteinizing hormone and FSH levels were significantly higher in those patients treated with EBRT at three months (luteinizing hormone 8,54 vs. 4,76 U/l, FSH 22,96 vs. 8,18 U/l, p<0,0001) while T and free testosterone levels were significantly lower (T 360,3 vs. 414,83ng/dl, p 0,039; free testosterone 5,94 vs. 7,5pg/ml, p 0,018). At 12 months FSH levels remained significantly higher in patients treated with EBRT compared to patients treated with RP (21,01 vs. 8,51 U/l, p<0,001) while T levels remained significantly lower (339,89 vs. 402,39ng/dl, p 0,03).
  
  
  CONCLUSIONS
  Prostate cancer treatment influences the hypothalamic pituitary axis. This influence seems to be more important when patients with prostate cancer are treated with EBRT rather than RP. More studies are needed to elucidate the role that prostate may play as an endocrine organ.
authors.affiliation: Servicio de Urología, Hospital Universitari Vall d'Hebrón, Universitat Autònoma de Barcelona, Barcelona, España. Electronic address: jplanas@vhebron.net.
authors.forename: J
authors.initials: J
authors.lastname: Planas
authors.affiliation: Servicio de Urología, Hospital Universitari Vall d'Hebrón, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: A
authors.initials: A
authors.lastname: Celma
authors.affiliation: Servicio de Urología, Hospital Universitari Vall d'Hebrón, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: Placer
authors.affiliation: Servicio de Radioterapia, Hospital Universitari Vall d'Hebrón, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: X
authors.initials: X
authors.lastname: Maldonado
authors.affiliation: Servicio de Urología, Hospital Universitari Vall d'Hebrón, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: E
authors.initials: E
authors.lastname: Trilla
authors.affiliation: Servicio de Urología, Hospital Universitari Vall d'Hebrón, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: C
authors.initials: C
authors.lastname: Salvador
authors.affiliation: Servicio de Urología, Hospital Universitari Vall d'Hebrón, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: D
authors.initials: D
authors.lastname: Lorente
authors.affiliation: Servicio de Urología, Hospital Universitari Vall d'Hebrón, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: L
authors.initials: L
authors.lastname: Regis
authors.affiliation: Servicio de Urología, Hospital Universitari Vall d'Hebrón, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: M
authors.initials: M
authors.lastname: Cuadras
authors.affiliation: Servicio de Oncología Médica, Hospital Universitari Vall d'Hebrón, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: Carles
authors.affiliation: Servicio de Urología, Hospital Universitari Vall d'Hebrón, Universitat Autònoma de Barcelona, Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: Morote
mesh_terms: D000368:Aged; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000097:blood / Q000532:radiotherapy* / Q000601:surgery*; D012189:Retrospective Studies; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Cáncer de próstata; Gonadotrophin; Gonadotropina; Prostate cancer; Prostatectomía radical; Radical prostatectomy; Radioterapia; Radiotherapy; Testosterona; Testosterone