title: "Reverse Tigroid" Pattern in Pachygyria: A Novel Finding.
abstract: Pachygyria is considered a subtype of lissencephaly which, in turn, is a spectrum of disorders caused by abnormal neuronal migration. Clinical presentation in this disorder may be varied including microcephaly, developmental delay, facial dysmorphism, seizures, and mental retardation. Magnetic resonance imaging (MRI) of brain identifies the exact nature and extent of the disease and helps in delineating further plan of management. A Tigroid pattern on axial MRI scan and leopard pattern on a sagittal plane has been classically reported in disorders of myelin formation such as metachromatic leukodystrophy and Pelizaeus-Merzbacher disease. We present here a case of pachygyria who presented to us with some atypical features including "tigroid-like stripes" and "leopard-like pattern" on MRI brain which has not been reported in the medical literature previously.
authors.affiliation: Department of Neurology, Bangur Institute of Neurosciences, IPGMER, Kolkata, West Bengal, India.
authors.forename: Ujjawal
authors.initials: U
authors.lastname: Roy
authors.affiliation: Department of Neurology, Bangur Institute of Neurosciences, IPGMER, Kolkata, West Bengal, India.
authors.forename: Alak
authors.initials: A
authors.lastname: Pandit
authors.affiliation: Department of Neurology, Bangur Institute of Neurosciences, IPGMER, Kolkata, West Bengal, India.
authors.forename: Urmila
authors.initials: U
authors.lastname: Das
authors.affiliation: Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Panwar
keywords: Lissencephaly; malformations of cortical development; metachromatic leukodystrophy