title: In patients with a tumour invading the phrenic nerve does prophylactic diaphragm plication improve postoperative lung function?
abstract: A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was 'In patients with tumours involving the phrenic nerve, does prophylactic diaphragm plication improve lung function following tumour resection?' Using the reported search, 258 papers were found of which 6 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Three case reports and one case series represent 37 patients in the literature along with two relevant animal studies. Patients treated with prophylactic plication at the time of injury or sacrifice of the phrenic nerve had reduced radiological evidence of diaphragm paralysis, lower reported shortness of breath and reduced requirement for ventilatory support. In patients with prophylactic diaphragm plication and a concurrent pulmonary resection, the predicted postoperative lung function correlated closely with the postoperative measured FEV1, FVC and gas transfer. The postoperative measured FEV1 was reported as 86-98%, the FVC 82-89% and gas transfer 97% of the predicted values. Two animal models investigate the mechanics of respiration, spirometry and gas exchange following diaphragmatic plication. A randomized control study in four dogs measured a 50% reduction in tidal volume and respiratory rate, a 40% decrease in arterial PO2 and a 43% increase in arterial CO2 when the phrenic nerve was crushed in animals with a pneumonectomy but without prophylactic diaphragm plication. A further randomized control animal study with 28 dogs found that plicating the diaphragm after unilateral phrenic nerve transection resulted in a significant increase in tidal volume and lung compliance and a significant decrease in respiratory frequency and the work of breathing. Prophylactic diaphragm plication may preserve lung function, reduce the risk of ventilator dependence and improve the mechanics of breathing in patients with phrenic nerve transection. If transection of the phrenic nerve occurs, and it is recognized intraoperatively, prophylactic diaphragm plication should be considered.
authors.affiliation: Department of Thoracic Surgery, Golden Jubilee National Hospital, Clydebank, Dunbartonshire, UK gwynbeattie@doctors.org.uk.
authors.forename: Gwyn W
authors.initials: GW
authors.lastname: Beattie
authors.affiliation: School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
authors.forename: William G
authors.initials: WG
authors.lastname: Dunn
authors.affiliation: Department of Thoracic Surgery, Golden Jubilee National Hospital, Clydebank, Dunbartonshire, UK.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Asif
mesh_terms: D003964:Diaphragm / Q000294:innervation / Q000601:surgery*; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010791:Phrenic Nerve / Q000473:pathology*; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D012129:Respiratory Function Tests; D012133:Respiratory Paralysis / Q000209:etiology / Q000517:prevention & control*; D019616:Thoracic Surgical Procedures / Q000009:adverse effects; D013934:Thymectomy; D013945:Thymoma / Q000473:pathology* / Q000601:surgery
keywords: Diaphragm; Humans; Neoplasms; Phrenic nerve; Thoracic surgery; Thoracic surgical procedures