title: Hematopoietic Stem Cell Niche in Health and Disease.
abstract: Regulation of stem cells in adult tissues is a key determinant of how well an organism can respond to the stresses of physiological challenge and disease. This is particularly true of the hematopoietic system, where demands on host defenses can call for an acute increase in cell production. Hematopoietic stem cells receive the regulatory signals for cell production in adult mammals in the bone marrow, a tissue with higher-order architectural and functional organization than previously appreciated. Here, we review the data defining particular structural components and heterologous cells in the bone marrow that participate in hematopoietic stem cell function. Further, we explore the case for stromal-hematopoietic cell interactions contributing to neoplastic myeloid disease. As the hematopoietic regulatory networks in the bone marrow are revealed, it is anticipated that strategies will emerge for how to enhance or inhibit production of specific blood cells. In that way, the control of hematopoiesis will enter the domain of therapies to modulate broad aspects of hematopoiesis, both normal and malignant.
authors.affiliation: Harvard Stem Cell Institute, Cambridge, Massachusetts 02138.|Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138.|Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114; email: dscadden@mgh.harvard.edu.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Hoggatt
authors.affiliation: Harvard Stem Cell Institute, Cambridge, Massachusetts 02138.|Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138.|Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114; email: dscadden@mgh.harvard.edu.
authors.forename: Youmna
authors.initials: Y
authors.lastname: Kfoury
authors.affiliation: Harvard Stem Cell Institute, Cambridge, Massachusetts 02138.|Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138.|Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114; email: dscadden@mgh.harvard.edu.
authors.forename: David T
authors.initials: DT
authors.lastname: Scadden
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology*; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D055153:Stem Cell Niche
keywords: bone marrow; hematopoiesis; hypoxia; leukemia; malignancy; mesenchymal cell