title: High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.
abstract: We investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011-June 2014 that had optimized clinical management and analyzed the relationship between E-test MICs for vancomycin, daptomycin, oxacillin, and linezolid and development of complicated bacteremia by using multivariate analysis. Complicated MSSA CRBSI occurred in 26 (31.3%) patients; MICs for vancomycin and daptomycin were higher in these patients (optimal cutoff values for predictive accuracy = 1.5 μg/mL and 0.5 μg/mL). High MICs for vancomycin (hazard ratio 2.4, 95% CI 1.2-5.5) and daptomycin (hazard ratio 2.4, 95% CI 1.1-5.9) were independent risk factors for development of complicated MSSA CRBSI. Our data suggest that patients with MSSA CRBSI caused by strains that have high MICs for vancomycin or daptomycin are at increased risk for complications.
authors.forename: Rafael
authors.initials: R
authors.lastname: San-Juan
authors.forename: Esther
authors.initials: E
authors.lastname: Viedma
authors.forename: Fernando
authors.initials: F
authors.lastname: Chaves
authors.forename: Antonio
authors.initials: A
authors.lastname: Lalueza
authors.forename: Jesús
authors.initials: J
authors.lastname: Fortún
authors.forename: Elena
authors.initials: E
authors.lastname: Loza
authors.forename: Miquel
authors.initials: M
authors.lastname: Pujol
authors.forename: Carmen
authors.initials: C
authors.lastname: Ardanuy
authors.forename: Isabel
authors.initials: I
authors.lastname: Morales
authors.forename: Marina
authors.initials: M
authors.lastname: de Cueto
authors.forename: Elena
authors.initials: E
authors.lastname: Resino-Foz
authors.forename: Alejandra
authors.initials: A
authors.lastname: Morales-Cartagena
authors.forename: Alicia
authors.initials: A
authors.lastname: Rico
authors.forename: María P
authors.initials: MP
authors.lastname: Romero
authors.forename: María Ángeles
authors.initials: MÁ
authors.lastname: Orellana
authors.forename: Francisco
authors.initials: F
authors.lastname: López-Medrano
authors.forename: Mario
authors.initials: M
authors.lastname: Fernández-Ruiz
authors.forename: José María
authors.initials: JM
authors.lastname: Aguado
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy* / Q000453:epidemiology; D055499:Catheter-Related Infections / Q000188:drug therapy* / Q000453:epidemiology; D015897:Comorbidity; D017576:Daptomycin / Q000494:pharmacology / Q000627:therapeutic use*; D019468:Disease Management; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000453:epidemiology; D016896:Treatment Outcome; D014640:Vancomycin / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D017576:Daptomycin
keywords: CRBI; MIC; MSSA; bacteria; catheter-related bloodstream infection; complicated bacteremia; daptomycin; methicillin-sensitive Staphylococcus aureus; septic thrombophlebitis; vancomycin