title: Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae.
abstract: The Zimbabwean medicinal plant Monadenium lugardae was evaluated as a potential source of new anticancer constituents. Four new tetracyclic triterpene (1-4) were isolated, accompanied by four previously known triterpenes (5-8). Against a panel of human tumor cell lines, lugardstatins 1 (1) and 2 (2) had good cancer cell growth inhibitory activity. All of the triterpene structures (1-8) were established by 1D and 2D NMR spectrometric and HR mass spectrometric analysis.
authors.affiliation: Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University , PO Box 871604, Tempe, Arizona 85287-1604, United States.
authors.forename: George R
authors.initials: GR
authors.lastname: Pettit
authors.affiliation: Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University , PO Box 871604, Tempe, Arizona 85287-1604, United States.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Ye
authors.affiliation: Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University , PO Box 871604, Tempe, Arizona 85287-1604, United States.
authors.forename: Delbert L
authors.initials: DL
authors.lastname: Herald
authors.affiliation: Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University , PO Box 871604, Tempe, Arizona 85287-1604, United States.
authors.forename: John C
authors.initials: JC
authors.lastname: Knight
authors.affiliation: Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University , PO Box 871604, Tempe, Arizona 85287-1604, United States.
authors.forename: Fiona
authors.initials: F
authors.lastname: Hogan
authors.affiliation: Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University , PO Box 871604, Tempe, Arizona 85287-1604, United States.
authors.forename: Noeleen
authors.initials: N
authors.lastname: Melody
authors.affiliation: Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University , PO Box 871604, Tempe, Arizona 85287-1604, United States.
authors.forename: Venugopal J R V
authors.initials: VJ
authors.lastname: Mukku
authors.affiliation: Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University , PO Box 871604, Tempe, Arizona 85287-1604, United States.
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Doubek
authors.affiliation: Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University , PO Box 871604, Tempe, Arizona 85287-1604, United States.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Chapuis
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D007941:Leukemia P388; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015030:Zimbabwe
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes