title: Investigation of the human FCRL1, 2, and 4 gene expressions in patients with rheumatoid arthritis.
abstract: The Fc receptor-like (FCRL) molecules have recently been shown to contribute to the pathogenesis of certain autoimmune disorders. In this study, we investigated the expression levels of FCRL1, 2 and 4 in blood mononuclear cells from rheumatoid arthritis patients using real-time PCR. The mRNA of these molecules was detected in 44.4 % (FCRL1), 53.3 % (FCRL2) and 31.1 % (FCRL4) of patients. Comparatively, 31.1 % (FCRL1), 51.1 % (FCRL2) and 26.6 % (FCRL4) of controls expressed these genes. Analysis of gene expressions in FCRL-positive patients demonstrated a lower FCRL4 gene expression in patients compared to controls (P < 0.001). In FCRL2-positive patients, a significant positive correlation between FCRL2 expression and the erythrocyte sedimentation rate (P < 0.001), anti-cyclic citrullinated peptide antibody (P = 0.033) level and disease activity score (DAS28, P = 0.016) was found. In conclusion, decreased FCRL4 expression and association of FCRL2 expression with inflammatory markers and disease activity suggested the contribution of these molecules to RA inflammatory processes.
authors.affiliation: Immunology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Khanzadeh
authors.affiliation: Rheumatology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Habibagahi
authors.affiliation: Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Hosseini
authors.affiliation: Immunology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. amirghz@sums.ac.ir.|Department of Immunology, Autoimmune Disease Research Center and Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. amirghz@sums.ac.ir.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Amirghofran
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000235:genetics*; D011961:Receptors, Fc / Q000235:genetics*; D055815:Young Adult
chemical_list: C551993:FCRL1 protein, human; C422179:FCRL2 protein, human; C423544:FCRL4 protein, human; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D011961:Receptors, Fc
keywords: Fc receptor-like molecules; Real-time PCR; Rheumatoid arthritis; mRNA