title: Effect of chronic fluoxetine treatment on audiogenic epilepsy, symptoms of anxiety and depression in rats of four lines.
abstract: Anxiety (Anx) and depression (Dp) levels were evaluated in rats of 4 lines: 2 of them (KM and "4") exhibited audiogenic seizures (AS), and 2 (Wistar and "0") had no AS. In KM rats (with AS), Anx and Dp levels were higher than in Wistars (without AS), while in "4" and "0" rats with the related genetic background but contrasting in AS severity, Anx and Dp indices were not different. Fluoxetine treatment exerted antidepressant effect in all rat lines irrespective of its effect on AS. Thus, phenotypic expression of AS is not directly associated with the mechanisms of Anx and Dp development.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, RAS, Moscow, Russia.
authors.forename: K Yu
authors.initials: KY
authors.lastname: Sarkissova
authors.affiliation: Moscow State University, Moscow, Russia.
authors.forename: I B
authors.initials: IB
authors.lastname: Fedotova
authors.affiliation: Moscow State University, Moscow, Russia.
authors.forename: N M
authors.initials: NM
authors.lastname: Surina
authors.affiliation: Moscow State University, Moscow, Russia.
authors.forename: G M
authors.initials: GM
authors.lastname: Nikolaev
authors.affiliation: Moscow State University, Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Perepelkina
authors.affiliation: Moscow State University, Moscow, Russia. ingapoletaeva@mail.ru.
authors.forename: I I
authors.initials: II
authors.lastname: Poletaeva
mesh_terms: D000818:Animals; D001007:Anxiety / Q000188:drug therapy / Q000503:physiopathology; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology; D020195:Epilepsy, Reflex / Q000188:drug therapy / Q000503:physiopathology; D005473:Fluoxetine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
chemical_list: D005473:Fluoxetine