title: [Prevalence of chronic kidney disease and its risk factors in subjects with different glucose metabolism status].
abstract: OBJECTIVE
  To investigate the prevalence of chronic kidney disease (CKD) in subjects with different glucose metabolism status.
  
  
  METHODS
  Between January, 2015 and October, 2015, a total of 934 subjects without a previous diagnosis of diabetes visiting the Department of Endocrinology or Health Examination Center underwent oral glucose tolerance test (OGTT), which identified 266 subjects with normal glucose tolerance (NGT group), 243 pre-diabetic subjects, and 425 patients with diabetes mellitus group. The baseline characteristics and laboratory test data of the subjects were collected. The diagnosis of CKD was established for an eGFR <60 mL/min/1.73 m(2) or a ACR≥30 mg/g, and the prevalence of CKD were compared among the 3 groups. Logistic regression model was used to analyze the OR value of the risk factors of CKD.
  
  
  RESULTS
  The prevalences of CKD in NGT, pre-diabetic and diabetic groups were 10.2%, 26.3% and 32.5%, respectively. Pairwise comparisons showed that the prevalence of CKD was significantly higher in pre-diabetic group (P<0.001, OR=3.17, 95% CI 1.94-5.17) and diabetic group (P<0.001, OR=4.27, 95% CI 2.72-6.65) than in NGT group, and was comparable between the pre-diabetic and diabetic groups (P=0.115, OR=1.35, 95% CI 0.95-1.91). Logistic regression analysis, after adjustment for age, gender, blood pressure, hypertension, blood lipids and uric acid, showed that pre-diabetes (OR=2.03, P=0.044) and diabetes mellitus (OR=2.22, P=0.016) were independently associated with CKD.
  
  
  CONCLUSIONS
  Glucose metabolism status has a significant independent impact on the incidence of CKD, suggesting the importance of early detection of pre-diabetes and timely interventions in pre-diabetic subjects in prevention CKD.
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.E-mail: qianrongxiao@hotmail.com.
authors.forename: Qian-Rong
authors.initials: QR
authors.lastname: Xiao
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Fan
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: De-Fu
authors.initials: DF
authors.lastname: Zhao
authors.forename: Heng
authors.initials: H
authors.lastname: Wan
authors.forename: Dao-Yan
authors.initials: DY
authors.lastname: Pan
authors.forename: Xu
authors.initials: X
authors.lastname: Lin
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
mesh_terms: D003920:Diabetes Mellitus / Q000453:epidemiology*; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D011236:Prediabetic State / Q000453:epidemiology*; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology*; D012307:Risk Factors
chemical_list: D005947:Glucose