title: Hybrid Mass Spectrometry: Towards Characterization of Protein Conformational States.
abstract: A current challenge in structural biology is to unravel the conformational states of protein complexes. Hybrid mass spectrometry (MS) has emerged as a key tool to study the structural dynamics of large protein complexes unattainable by traditional methods. Here, we discuss recent advances in hybrid MS allowing characterization of challenging biological systems.
authors.affiliation: Department of Chemistry, King's College London, London, UK.
authors.forename: Zainab
authors.initials: Z
authors.lastname: Ahdash
authors.affiliation: Department of Chemistry, King's College London, London, UK; Department of Chemistry, Imperial College London, London, UK.
authors.forename: Euan
authors.initials: E
authors.lastname: Pyle
authors.affiliation: Department of Chemistry, King's College London, London, UK. Electronic address: argyris.politis@kcl.ac.uk.
authors.forename: Argyris
authors.initials: A
authors.lastname: Politis
mesh_terms: D013058:Mass Spectrometry / Q000379:methods*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins
keywords: conformational states; hybrid approaches; integrative modelling; mass spectrometry; protein complexes