title: MicroRNA-125b promotes invasion and metastasis of gastric cancer by targeting STARD13 and NEU1.
abstract: MicroRNAs have been documented playing key roles in cancer development and progression. Here, we investigate the role of miR-125b in gastric cancer metastasis. We found that the expression of miR-125b was up-regulated in gastric cancer tissue specimens compared with their corresponding nontumorous tissues, and the up-regulated miR-125b level was significantly associated with TNM stage and lymph node-metastasis. Overexpression of miR-125b promoted gastric cancer cell migration and invasion in vitro and metastasis in vivo. STARD13 and NEU1 were identified as direct target genes of miR-125b by luciferase assays, and they were involved in the cell migration and invasion regulated by miR-125b in gastric cancer. Taken together, miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer.
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi Province, 710061, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Chang
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi Province, 710061, China.
authors.forename: Shicai
authors.initials: S
authors.lastname: He
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi Province, 710061, China.
authors.forename: Guanglin
authors.initials: G
authors.lastname: Qiu
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi Province, 710061, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi Province, 710061, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi Province, 710061, China.
authors.forename: Junsong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi Province, 710061, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Fan
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi Province, 710061, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi Province, 710061, China. chexiang@mail.xjtu.edu.cn.
authors.forename: Xiangming
authors.initials: X
authors.lastname: Che
mesh_terms: D000328:Adult; D000818:Animals; D045744:Cell Line, Tumor; D002465:Cell Movement; D005260:Female; D020690:GTPase-Activating Proteins; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D035683:MicroRNAs / Q000502:physiology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009439:Neuraminidase / Q000235:genetics*; D013274:Stomach Neoplasms / Q000473:pathology*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: D020690:GTPase-Activating Proteins; C531888:MIRN125 microRNA, human; D035683:MicroRNAs; C473607:STARD13 protein, human; D025521:Tumor Suppressor Proteins; C486385:NEU1 protein, human; D009439:Neuraminidase
keywords: Gastric cancer; Metastasis; MicroRNA-125b; NEU1; STARD13