title: Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance.
abstract: The daily production of billions of platelets must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Complex mechanisms control platelet production and clearance in physiological and pathological conditions. This review will focus on the mechanisms of platelet senescence with specific emphasis on the role of post-translational modifications in platelet life-span and thrombopoietin production downstream of the hepatic Ashwell-Morrell receptor.
authors.affiliation: Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115. Electronic address: khoffmeister@bwh.harvard.edu.
authors.forename: Karin M
authors.initials: KM
authors.lastname: Hoffmeister
authors.affiliation: Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.
authors.forename: Hervé
authors.initials: H
authors.lastname: Falet
mesh_terms: D000818:Animals; D037263:Asialoglycoprotein Receptor / Q000378:metabolism*; D001792:Blood Platelets / Q000166:cytology* / Q000378:metabolism / Q000473:pathology; D016922:Cellular Senescence; D006801:Humans; D011499:Protein Processing, Post-Translational; D019947:Receptors, Interleukin-6 / Q000378:metabolism; D015398:Signal Transduction; D013926:Thrombopoietin / Q000378:metabolism
chemical_list: D037263:Asialoglycoprotein Receptor; D019947:Receptors, Interleukin-6; D013926:Thrombopoietin
keywords: Ashwell Morell Receptor; JAK2; STAT3; glycans; platelet clearance; thrombopoietin