title: Evaluation of Plasmatic Concentration of Propofol 2.5µg/ml by TCI using Marsh Modified Model, during oocyte retrieval for IVF in Latin-American women (Venezuelans).
abstract: OBJECTIVE
  To evaluate efficacy of Propofol at Cp 2.5 µg/ ml administered by Target Controlled Infusion (TCI) using Marsh Modified Model, in pre-medicated with midazolam/ fentanil Latin-American women (Venezuelans) during oocyte retrieval for In Vitro Fertilization.
  
  
  METHODS
  Prospective, descriptive study included 72 women, 18-44 years old, ASA I-II, non obese, undergoing oocyte retrieval, pre-medicated with midazolam 0.04 mg/kg and fentanil 2µg/kg and received anesthesia based in Propofol at Cp 2.5µg/ml by Target Controlled Infusion using Marsh Modified Model. Demographic data, propofol doses, duration of procedure and recovery time was registered using descriptive statistic. Anesthesia efficacy was measured by Biespectral Analysis (BIS), Intra-Operative Movements Scale (0 to 5) graded, Postoperative Pain by Visual Analog Scale (VAS) and nausea/vomits incidence. ANOVA and Pearson Chi2 were used with an error of 0.05.
  
  
  RESULTS
  Age average was 33.04±6 years old, procedure average time 18.06±8min, Propofol total doses 146.64±53 mgs, Propofol infusion doses average 155.2±3µg/Kg/min. During procedure, 70.8% of patients had no movement, 22.2% movement Grade I and 6.9% Grade II. (Grade I-II movement did not interfere with procedure continuity). 70.8% achieved BIS 40-50 and 93.1% had BIS equal o less than 60. There was a statistic significant correlation between BIS 40-50 and no movements. Recovery post-anesthesia time was 25.2±8 min. 98.6% of patients reported excellent comfort.
  
  
  CONCLUSIONS
  With midazolam/fentanil pre-medication, Propofol at Cp 2.5µg/ml by TCI using Marsh Modified Model showed a 93% of effectiveness during oocyte retrieval in Latin-American women subjected to IVF, allowing an ultra- fast recovery time.
authors.affiliation: Clinica El Avila, Caracas, Venezuela.|Unifertes Fertility Center, Caracas, Venezuela.
authors.forename: Carlos
authors.initials: C
authors.lastname: Ramìrez-Paesano
authors.affiliation: Clinica El Avila, Caracas, Venezuela.|Unifertes Fertility Center, Caracas, Venezuela.
authors.forename: Isaac Benjamin
authors.initials: IB
authors.lastname: Fhima
authors.affiliation: Clinica El Avila, Caracas, Venezuela.|Unifertes Fertility Center, Caracas, Venezuela.
authors.forename: Randolfo
authors.initials: R
authors.lastname: Medina
authors.affiliation: Clinica El Avila, Caracas, Venezuela.|Unifertes Fertility Center, Caracas, Venezuela.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Urbina
authors.affiliation: Clinica El Avila, Caracas, Venezuela.|Unifertes Fertility Center, Caracas, Venezuela.
authors.forename: Carlos
authors.initials: C
authors.lastname: Martínez
authors.affiliation: Clinica El Avila, Caracas, Venezuela.|Unifertes Fertility Center, Caracas, Venezuela.
authors.forename: Jorge Lerner
authors.initials: JL
authors.lastname: Biber
keywords: In Vitro Fertilization (IVF); Latin American women; Propofol; Target Controlled Infusion (TCI); Total Intravenous Anesthesia (TIVA)