title: Hyperuricemia, Cardiovascular Disease, and Hypertension.
abstract: In recent years, there has been an increase in the prevalence of hyperuricemia, and the latter has attracted attention as an adult lifestyle-associated disease, together with hypertension, diabetes, and dyslipidemia. Although hyperuricemia is known to be an independent risk factor for hypertension, whether it is an independent risk factor for cardiovascular disease remains controversial. Recently, some small-scale interventional studies on antihyperuricemic medications showed that the latter improved angina symptoms and prevented cardiovascular disease. Here, we will mainly explain the cause of hyperuricemia and the associations between hyperuricemia, hypertension, and cardiovascular disease based on the latest published evidence.
authors.affiliation: Department of Cardiology, Toranomon Hospital, and Department of Cardiology, St. Luke's International Hospital, Tokyo, Japan.
authors.forename: Masanari
authors.initials: M
authors.lastname: Kuwabara
keywords: Cardiovascular disease; Hypertension; Risk factor; Uric acid; Uric acid transporter