title: Intrahepatic biliary cystadenoma-diagnosis and treatment options.
abstract: OBJECTIVE
  Liver cystadenomas are rare conditions accounting to approximately 5% of all cystic lesions. The aim of our study was to establish a new diagnostic and complex therapeutic approach.
  
  
  METHODS
  In all, 12 female patients primarily diagnosed with cystadenoma of the liver were evaluated. Enucleation of the cystadenoma was performed in six (54.5%) and liver resection in four (33.3%) patients. Due to the localization, complete enucleation or radical liver resection could not be performed in two patients.
  
  
  RESULTS
  In three patients, grade III-a complications were recorded after surgery. The 30-day mortality was 0%. The length of hospitalization was 27 (7-52) days. Malignant transformation occurred in two patients with incomplete removal of the cystadenoma. In both cases, carbohydrate antigen 19-9 serum levels were elevated during the follow-up period. The first patient died 28 months after primary surgery. The second patient failed to attend any further appointments. The remaining patients are in the good conditions, with no signs of recurrence.
  
  
  CONCLUSIONS
  The only possible treatment of cystadenomas is their radical surgical removal. Any other incomplete surgical treatment is insufficient and associated with a high risk of malignant transformation. For patients in whom R0 resection or complete enucleation cannot be performed for technical reasons, liver transplantation should be considered.
authors.affiliation: Department of Surgery, Charles University Prague Faculty of Medicine and Faculty Hospital Pilsen, Prague, Czech Republic. treska@fnplzen.cz.
authors.forename: Vladislav
authors.initials: V
authors.lastname: Treska
authors.forename: Jiri
authors.initials: J
authors.lastname: Ferda
authors.forename: Ondrej
authors.initials: O
authors.lastname: Daum
authors.forename: Vaclav
authors.initials: V
authors.lastname: Liska
authors.forename: Tomas
authors.initials: T
authors.lastname: Skalicky
authors.forename: Jan
authors.initials: J
authors.lastname: Bruha
mesh_terms: D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology / Q000601:surgery*; D003537:Cystadenoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D011184:Postoperative Period; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; C578959:carbohydrate antigen 199, human