title: Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor.
abstract: Two-dimensional MoS2 nanosheet has been extensively explored as a photothermal agent for tumor regression; however, its surface modification remains a great challenge. Herein, as an alternative to surface polyethylene glycol modification (PEGylation), a facile approach based on "thin-film" strategy has been proposed for the first time to produce soybean phospholipid-encapsulated MoS2 (SP-MoS2) nanosheets. By simply vacuum-treating MoS2 nanosheets/soybean phospholipid/chloroform dispersion in a rotary evaporator, SP-MoS2 nanosheet was successfully constructed. Owing to the steric hindrance of polymer chains, the surface-coated soybean phospholipid endowed MoS2 nanosheets with excellent colloidal stability. Without showing detectable in vitro and in vivo hemolysis, coagulation, and cyto-/histotoxicity, the constructed SP-MoS2 nanosheets showed good photothermal conversion performance and photothermal stability. SP-MoS2 nanosheet was shown to be a promising platform for in vitro and in vivo breast tumor photothermal therapy. The produced SP-MoS2 nanosheets featured low cost, simple fabrication, and good in vivo hemo-/histocompatibility and hold promising potential for future clinical tumor therapy.
authors.affiliation: Department of Breast-Thyroid Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai, People's Republic of China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: College of Science, University of Shanghai for Science and Technology, Shanghai, People's Republic of China; Shanghai Publishing and Printing College, Shanghai, People's Republic of China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Gong
authors.affiliation: Department of Breast-Thyroid Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai, People's Republic of China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Breast-Thyroid Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Breast-Thyroid Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai, People's Republic of China.
authors.forename: Huanhuan
authors.initials: H
authors.lastname: Yan
authors.affiliation: College of Science, University of Shanghai for Science and Technology, Shanghai, People's Republic of China.
authors.forename: Shige
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Breast-Thyroid Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D045744:Cell Line, Tumor; D002470:Cell Survival; D004220:Disulfides / Q000138:chemical synthesis*; D005260:Female; D006461:Hemolysis; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007150:Immunohistochemistry; D015674:Mammary Neoplasms, Animal / Q000473:pathology / Q000628:therapy*; D008422:Materials Testing; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008982:Molybdenum; D053758:Nanoparticles / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry*; D010789:Phototherapy / Q000379:methods*; D012074:Remission Induction; D013025:Glycine max / Q000737:chemistry*
chemical_list: D004220:Disulfides; D010743:Phospholipids; D008982:Molybdenum; C082964:molybdenum disulfide
keywords: MoS2 nanosheets; breast tumor; in vivo; photothermal regression; soybean phospholipid