title: Plasma oxidative stress level of IgA nephropathy in children and the effect of early intervention with angiotensin-converting enzyme inhibitors.
abstract: OBJECTIVE
  The purpose of this study was to investigate the change of the plasma oxidative stress level in children with IgA nephropathy (IgAN) and analyze its relativity to the clinical and pathological classification. To discuss the early effects of angiotensin-converting enzyme inhibitors (ACEIs) on the plasma oxidative stress level in children with IgA nephropathy.
  
  
  METHODS
  Thirty-eight children with IgAN were divided into groups according to their clinical features, pathologic grades, and treatments. Twenty healthy children were included in the control group.
  
  
  RESULTS
  The plasma level of advanced oxidation protein products (AOPPs), malonaldehyde (MDA), and superoxide dismutase (SOD) were detected. The plasma level of oxidative stress was significantly increased in the IgAN group, including a higher plasma level of AOPP and MDA and a lower plasma level of SOD. After treatment, the plasma level of oxidative stress was significantly decreased in the ACEI group.
  
  
  CONCLUSIONS
  The children with IgAN had an increase in the plasma level of oxidative stress, expressed as an increased plasma level of AOPP and MDA and a decreased plasma level of SOD. Oxidative stress was associated with the progression of IgAN in children. Early treatment with ACEI therapy can significantly reduce the plasma level of oxidative stress in children with IgAN.
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, P.R. China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Pei
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, P.R. China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, P.R. China.
authors.forename: Jingwei
authors.initials: J
authors.lastname: Ruan
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, P.R. China.
authors.forename: Liping
authors.initials: L
authors.lastname: Rong
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, P.R. China.
authors.forename: Mengjie
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Mo
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, P.R. China jiangxiaoyun2015@126.com.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D005922:Glomerulonephritis, IGA / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors
keywords: IgA nephropathy; angiotensin converting enzyme inhibitor; children; glomerulonephritis; oxidative stress