title: Effects of aqueous extract from Asparagus officinalis L. roots on hypothalamic-pituitary-gonadal axis hormone levels and the number of ovarian follicles in adult rats.
abstract: BACKGROUND
  Asparagus is a plant with high nutritional, pharmaceutical, and industrial values.
  
  
  OBJECTIVE
  The present study aimed to evaluate the effect of aqueous extract of asparagus roots on the hypothalamic-pituitary-gonadal axis hormones and oogenesis in female rats.
  
  
  METHODS
  In this experimental study, 40 adult female Wistar rats were divided into five groups, which consist 8 rats. Groups included control, sham and three experimental groups receiving different doses (100, 200, 400 mg/kg/bw) of aqueous extract of asparagus roots. All dosages were administered orally for 28 days. Blood samples were taken from rats to evaluate serum levels of Gonadotropin releasing hormone (GnRH), follicular stimulating hormone (FSH), Luteinal hormone (LH), estrogen, and progesterone hormones. The ovaries were removed, weighted, sectioned, and studied by light microscope.
  
  
  RESULTS
  Dose-dependent aqueous extract of asparagus roots significantly increased serum levels of GnRH, FSH, LH, estrogen, and progestin hormones compared to control and sham groups. Increase in number of ovarian follicles and corpus luteum in groups treated with asparagus root extract was also observed (p<0.05).
  
  
  CONCLUSIONS
  Asparagus roots extract stimulates secretion of hypothalamic- pituitary- gonadal axis hormones. This also positively affects oogenesis in female rats.
authors.affiliation: Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.
authors.forename: Hojatollah
authors.initials: H
authors.lastname: Karimi Jashni
authors.affiliation: Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Kargar Jahromi
authors.affiliation: Young Researchers and Elite Club, Kazerun Branch, Islamic Azad University, Kazerun, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Ghorbani Ranjbary
authors.affiliation: Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Kargar Jahromi
authors.affiliation: Young Researchers and Elite Club, Kazerun Branch, Islamic Azad University, Kazerun, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Khabbaz Kherameh
keywords: Asparagus officinalis; Hormones; Oogenesis; Ovary; Rat