title: [INDIVIDUAL EVALUATION OF LORETA ABNORMALITIES IN IDIOPATHIC GENERALIZED EPILEPSY].
abstract: BACKGROUND
  Contemporary neuroimaging methods disclosed structural and functional cerebral abnormalities in idiopathic generalized epilepsies (IGEs). However, individual electrical (EEG) abnormalities have not been evaluated yet in IGE patients.
  
  
  METHODS
  IGE patients were investigated in the drug-free condition and after 3-6 month of antiepileptic treatment. To estimate the reproducibility of qEEG variables a retrospective recruited cohort of IGE patients was investigated. 19-channel resting state EEG activity was recorded. For each patient a total of 2 minutes EEG activity was analyzed by LORETA (Low Resolution Electromagnetic Tomography). Raw LORETA values were Z-transformed and projected to a MRI template. Z-values outside within the [+3Z] to [-3Z] range were labelled as statistically abnormal.
  
  
  RESULTS
  1. In drug-free condition, 41-50% of IGE patients showed abnormal LORETA values. 2. Abnormal LORETA findings showed great inter-individual variability. 3. Most abnormal LORETA-findings were symmetrical. 4. Most maximum Z-values were localized to frontal or temporal cortex. 5. Succesfull treatment was mostly coupled with disappearence of LORETA-abnormality, persistent seizures were accompanied by persistent LORETA abnormality.
  
  
  CONCLUSIONS
  1. LORETA abnormalities detected in the untreated condition reflect seizure-generating property of the cortex in IGE patients. 2. Maximum LORETA-Z abnormalities were topographically congruent with structural abnormalities reported by other research groups. 3. LORETA might help to investigate drug effects at the whole-brain level.
authors.forename: Béla
authors.initials: B
authors.lastname: Clemens
authors.forename: Szilvia
authors.initials: S
authors.lastname: Puskás
authors.forename: Mónika
authors.initials: M
authors.lastname: Besenyei
authors.forename: István
authors.initials: I
authors.lastname: Kondákor
authors.forename: Katalin
authors.initials: K
authors.lastname: Hollódy
authors.forename: Andrós
authors.initials: A
authors.lastname: Fogarasi
authors.forename: Katalin
authors.initials: K
authors.lastname: Bense
authors.forename: Miklós
authors.initials: M
authors.lastname: Emri
authors.lastname: Opposits Gábor
authors.forename: Noémi Zsuzsanna
authors.initials: NZ
authors.lastname: Kovács
authors.forename: István
authors.initials: I
authors.lastname: Fekete
mesh_terms: D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000503:physiopathology*; D002648:Child; D004569:Electroencephalography; D055590:Electromagnetic Phenomena; D004829:Epilepsy, Generalized / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000002:abnormalities / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging / Q000379:methods*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013702:Temporal Lobe / Q000002:abnormalities / Q000503:physiopathology; D014054:Tomography; D055815:Young Adult