title: Catalytic asymmetric [3 + 3] annulation of cyclopropanes with mercaptoacetaldehyde.
abstract: A highly diastereo- and enantioselective [3 + 3] annulation of donor-acceptor cyclopropanes with mercaptoacetaldehyde has been developed. In the presence of a N,N'-dioxide-Sc(iii) complex as the catalyst, a number of aromatic substituted cyclopropyl ketones reacted with mercaptoacetaldehyde smoothly, providing the corresponding chiral tetrahydrothiopyranols in moderate yields with excellent ee (up to 99% ee) and dr values (up to >19 : 1).
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. lililin@scu.edu.cn xmfeng@scu.edu.cn.
authors.forename: Xuan
authors.initials: X
authors.lastname: Fu
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Yong
authors.initials: Y
authors.lastname: Xia
authors.forename: Pengfei
authors.initials: P
authors.lastname: Zhou
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng