title: Preparation and Adsorption Properties of Novel Porous Microspheres with Different Concentrations of Bilirubin.
abstract: BACKGROUND
  Plasma perfusion was widely used to clear toxic substances of plasma. Particle size and uniformity of adsorbent microspheres also affect the absorption rate.
  
  
  METHODS
  Conventional suspension polymerization was improved using a pre-dispersion homogenizer to obtain novel adsorbent microspheres, named ERM-0100. Microsphere-related characteristics and attributes were analysed.
  
  
  RESULTS
  The ERM-0100 microspheres efficiently adsorbed different bilirubin concentrations, with a maximum rate of 59.72 ± 1.08%. At high bilirubin concentrations, ERM-0100 exhibited similar adsorption rate with BRS350 and BS330 (p = 0.303, p = 1.000, relatively), and higher than HB-H-6 (p = 0.000). At different concentration, ERM-0100 showed good adsorption performance. The ERM-0100 had no significant adsorption for electrolyte; for TP and ALB, the loss rates of ERM-0100 were 15.65 ± 0.36 and 23.23 ± 1.11%, respectively. In addition, ERM-0100 showed good blood compatibility.
  
  
  CONCLUSIONS
  The ERM-0100 is a potential biomedical material for plasma perfusion for good effect, less costs and more safety. The microspheres may be coated to reduce its protein adsorption.
authors.affiliation: Biomedical Engineering Laboratory, Tianjin Research Institute of Liver Diseases, Tianjin, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Su
authors.forename: Yao
authors.initials: Y
authors.lastname: Rao
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Shen
authors.forename: Junna
authors.initials: J
authors.lastname: Zhu
authors.forename: Aiqing
authors.initials: A
authors.lastname: Ji
authors.forename: Guangrong
authors.initials: G
authors.lastname: Jin
authors.forename: Chenyang
authors.initials: C
authors.lastname: Dai
authors.forename: Wei
authors.initials: W
authors.lastname: Hou
authors.forename: Meili
authors.initials: M
authors.lastname: Yu
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
mesh_terms: D000327:Adsorption; D001663:Bilirubin / Q000302:isolation & purification*; D001672:Biocompatible Materials / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D008863:Microspheres; D010316:Particle Size; D010477:Perfusion / Q000379:methods* / Q000592:standards; D016062:Porosity; D011506:Proteins
chemical_list: D001672:Biocompatible Materials; D011506:Proteins; D001663:Bilirubin