title: Breast Cancer Subtypes in Patients Aged 70 Years and Older.
abstract: Recurrence and survival pattern in breast cancer (bc) patients (pts) ≥ 70 years subcategorized according to subtype and age are still an area of uncertainty. Tumor characteristics, patient demographics, therapies applied, and recurrence pattern were compared between luminal A (LA), luminal B (LB), Her2/neu overexpressing (Her+) and triple-negative (TN) bc subtypes and the age subcategories 70-74, 75-79, ≥80 years. Based on univariate Cox-regression-analyses distant-disease-free-survival (DDFS) differed significantly for bc subtypes (p = 0.0002), notably for Her+ vs. LA (p = 0.0014), TN vs. LA (p < 0.001), and TN vs. LB (p = 0.0086). Not age, but Her+ and TN represented prognostic factors for DDFS.
authors.affiliation: a Ludwig Boltzmann Institute for Applied Cancer Research (LBI-ACR VIEnna)-LB Cluster Translational Oncology, 3rd Medical Department-Centre for Oncology and Haematology, Kaiser Franz Josef-Spital , Vienna , Austria.|b Applied Cancer Research-Institution for Translational Research Vienna (ACR-ITR VIEnna)/CEADDP , Vienna , Austria.
authors.forename: Robert
authors.initials: R
authors.lastname: Königsberg
authors.affiliation: c Department of Obstetrics and Gynaecology , Medical University of Vienna , Vienna , Austria.
authors.forename: Georg
authors.initials: G
authors.lastname: Pfeiler
authors.affiliation: c Department of Obstetrics and Gynaecology , Medical University of Vienna , Vienna , Austria.
authors.forename: Nicole
authors.initials: N
authors.lastname: Hammerschmid
authors.affiliation: c Department of Obstetrics and Gynaecology , Medical University of Vienna , Vienna , Austria.
authors.forename: Oliver
authors.initials: O
authors.lastname: Holub
authors.affiliation: c Department of Obstetrics and Gynaecology , Medical University of Vienna , Vienna , Austria.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Glössmann
authors.affiliation: d Assign Data Management and Biostatistics GmbH, Assign Group , Innsbruck , Austria.
authors.forename: Julian
authors.initials: J
authors.lastname: Larcher-Senn
authors.affiliation: a Ludwig Boltzmann Institute for Applied Cancer Research (LBI-ACR VIEnna)-LB Cluster Translational Oncology, 3rd Medical Department-Centre for Oncology and Haematology, Kaiser Franz Josef-Spital , Vienna , Austria.|b Applied Cancer Research-Institution for Translational Research Vienna (ACR-ITR VIEnna)/CEADDP , Vienna , Austria.
authors.forename: Christian
authors.initials: C
authors.lastname: Dittrich
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor
keywords: Age categories; DDFS; Elderly patients; LRFS; adjuvant therapies; breast cancer subtypes