title: IgG4-Related Kidney Disease in a Patient With History of Breast Cancer: Findings on 18F-FDG PET/CT.
abstract: A 64-year-old African American woman with history of stage III breast carcinoma, 3 years after complete response to therapy, presents with progressive fatigue, increasing arthralgia, and unintentional weight loss of 15 lb in 3 months. An F-FDG PET demonstrated new diffuse FDG avidity of the renal parenchyma, new FDG-avid foci in pancreas and lungs, and new FDG-avid lymph nodes above and below the diaphragm. While a retroperitoneal lymph node biopsy was inconclusive, a kidney biopsy resulted in diagnosis of diffuse, severe, IgG4-related tubulointerstitial nephritis. Treatment with corticosteroid led to complete resolution of the symptoms and PET findings.
authors.affiliation: From the *Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY; †IRCCS SDN, Naples, Italy; and ‡Department of Pathology, Weill Cornell Medical College, New York, NY.
authors.forename: Simone
authors.initials: S
authors.lastname: Krebs
authors.forename: Serena
authors.initials: S
authors.lastname: Monti
authors.forename: Surya
authors.initials: S
authors.lastname: Seshan
authors.forename: Josef
authors.initials: J
authors.lastname: Fox
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Mannelli
mesh_terms: D001327:Autoimmune Diseases / Q000000981:diagnostic imaging* / Q000276:immunology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D002277:Carcinoma / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008875:Middle Aged; D009393:Nephritis / Q000000981:diagnostic imaging* / Q000276:immunology; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals
chemical_list: D007074:Immunoglobulin G; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18