title: Multidetector computed tomography shows reverse cardiac remodeling after double lung transplantation for pulmonary hypertension.
abstract: OBJECTIVE
  To use multidetector computed tomography (MDCT) to evaluate the structural changes in the right heart and pulmonary arteries that occur in patients with severe pulmonary hypertension treated by double lung transplantation.
  
  
  METHODS
  This was a retrospective study of 21 consecutive patients diagnosed with severe pulmonary hypertension who underwent double lung transplantation at our center between 2010 and 2014. We analyzed the last MDCT study done before lung transplantation and the first MDCT study done after lung transplantation. We recorded the following variables: diameter of the pulmonary artery trunk, ratio of the diameter of the pulmonary artery trunk to the diameter of the ascending aorta, diameter of the right ventricle, ratio of the diameter of the left ventricle to the diameter of the right ventricle, and eccentricity index. Statistical analysis consisted of the comparison of the means of the variables recorded.
  
  
  RESULTS
  In all cases analyzed, the MDCT study done a mean of 24±14 days after double lung transplantation showed a significant reduction in the size of the right heart chambers, with improved indices of ventricular interdependency index, and reduction in the size of the pulmonary artery trunk (p<0.001 for all the variables analyzed).
  
  
  CONCLUSIONS
  Patients with pulmonary hypertension treated by double lung transplantation present early reverse remodeling of the changes in the structures of the right heart and pulmonary arterial tree. MDCT is useful for detecting these changes.
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Universitario 12 de Octubre, Madrid, España. Electronic address: danimandich@gmail.com.
authors.forename: D
authors.initials: D
authors.lastname: Mandich Crovetto
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: S
authors.initials: S
authors.lastname: Alonso Charterina
authors.affiliation: Servicio de Cardiología, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: C
authors.initials: C
authors.lastname: Jiménez López-Guarch
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Pont Vilalta
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Pérez Núñez
authors.affiliation: Servicio de Neumología, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: A
authors.initials: A
authors.lastname: de Pablo Gafas
authors.affiliation: Servicio de Cardiología, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: P
authors.initials: P
authors.lastname: Escribano Subías
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000601:surgery*; D016040:Lung Transplantation / Q000379:methods; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D012189:Retrospective Studies; D020257:Ventricular Remodeling; D055815:Young Adult
keywords: Cardiac remodeling; Hipertensión pulmonar; Lung transplant; Multidetector computed tomography; Pulmonary hypertension; Remodelamiento cardíaco; Tomografía computarizada multidetector; Trasplante pulmonar