title: Stem cells and diabetic cardiomyopathy: from pathology to therapy.
abstract: The worldwide increase trend in the prevalence of diabetes has highlighted the need for increased research efforts into treatment options for both the disease itself and its associated complications. Diabetes has been widely recognized as a major risk factor for cardiovascular diseases, such as coronary heart disease and hypertension. Diabetic cardiomyopathy (DCM) is a main complication of diabetes, contributing to specific forms of heart failure independent from ischemia or hypertension. Without considerably effective approaches, a dire need exists to further explore the mechanisms and potential therapeutic strategies to prevent or reverse the progression of DCM. In the past decades, stem cell-based therapies have held promises to various diseases including DCM. The aim of the present review was to summarize the current literature with regard to the pathological changes of diabetic cardiomyopathy, endogenous stem cells in diabetes, and the exogenous stem cells transplantation for DCM. If the best use is made of the advantages of stem cells and their mechanism of action is explicitly explored, stem cell-based therapies could served as an important tool for the prevention and treatment of DCM patients.
authors.affiliation: Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
authors.forename: Mingfei
authors.initials: M
authors.lastname: Liu
authors.affiliation: Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
authors.forename: Han
authors.initials: H
authors.lastname: Chen
authors.affiliation: Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Intensive Care Unit, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
authors.forename: Zhaocai
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Dong
authors.affiliation: Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
authors.forename: Xinyang
authors.initials: X
authors.lastname: Hu
authors.affiliation: Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
authors.affiliation: Cardiovascular Key Lab of Zhejiang Province, Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China. Jian_an_wang@yahoo.com.
authors.forename: Jian'an
authors.initials: J
authors.lastname: Wang
mesh_terms: D058065:Diabetic Cardiomyopathies / Q000503:physiopathology* / Q000628:therapy*; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D007333:Insulin Resistance; D033581:Stem Cell Transplantation; D016896:Treatment Outcome
keywords: Cell therapy; Diabetic cardiomyopathy; Heart failure; Stem cell