title: [Effects of IAA/HRP on the proliferation and apoptosis of SACC-83 cells].
abstract: OBJECTIVE
  To study the effect of IAA/HRP on the proliferation and apoptosis of human SACC-83 cells in vitro,and its molecular mechanism.
  
  
  METHODS
  The rate of proliferation inhibition was determined by CCK-8 assay, the apoptosis-related gene Caspase-3 and Livinα mRNA and protein expression levels were measured by real-time PCR and Western blot.
  
  
  RESULTS
  IAA/HRP could inhibit proliferation of SACC-83, which depending on the time and dosage (P < 0.05); can-up-regulate the Caspase-3 mRNA and protein expression levels and reduction of the mRNA and protein of the Livina expression, (both P < 0.05).
  
  
  CONCLUSIONS
  IAA/HRP can inhibit the proliferation and induce the apoptosis of SACC-83 cells, which may due to its regulation of the expression of Caspase-3 and Livinα mRNA expression.
authors.forename: Jilian
authors.initials: J
authors.lastname: Lv
authors.forename: Ning
authors.initials: N
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: He
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D007210:Indoleacetic Acids / Q000494:pharmacology*; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C419866:BIRC7 protein, human; D007210:Indoleacetic Acids; D051034:Inhibitor of Apoptosis Proteins; D009363:Neoplasm Proteins; C030737:indoleacetic acid; C505407:CASP3 protein, human; D053148:Caspase 3