title: Cumulative Risk of Metabolic Syndrome Correlated with the Coexistence of (-1306C/T) and Altered Circulating MMP2 level.
abstract: BACKGROUND
  Interindividual genetic variations and environmental factors both play pivotal roles in the pathogenesis of metabolic syndrome (MetS). The rationale of this study conducted was to analyze the association of Matrix Metalloproteinase (MMP) gene variants, MMP-1 (-1607 1G/2G) and MMP-2 (-1306 C/T) with susceptibility to MetS and its effect on serum MMP level.
  
  
  METHODS
  Study involved 370 subjects with 1:1 distribution of cases and controls. Patients were recruited according to modified NCEP-ATP III criteria for MetS. Clinical, biochemical analysis, PCR-RFLP and ELISA methods were employed for genotyping and estimation of serum MMP level.
  
  
  RESULTS
  Significantly (p<0.001) higher Serum MMP-2 (39.13±19.96 ng/ml) was detected in cases as compared to controls. The MMP-2 (-1306 C/T) was significantly associated with the risk of MetS. The variant genotype TT was significantly associated with increased risk of MetS. (p=0.032; OR=2.31; 95%CI=1.07-4.97). No significant association of MMP-1(-1607 1G/2G) was found with risk of MetS.
  
  
  CONCLUSIONS
  Our study concluded that presence of MMP-2 (-1306 C/T) might be associated the risk of MetS. Serum MMP2 level was significantly higher in patients and correlated with clinical parameters of MetS. Clinical implication of the work may help to identify the individuals with high risk of MetS and further complications.
authors.affiliation: Department of Pharmacology and Therapeutics, King George's Medical University, Lucknow.
authors.forename: S S
authors.initials: SS
authors.lastname: Yadav
authors.affiliation: Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
authors.forename: R K
authors.initials: RK
authors.lastname: Mandal
authors.affiliation: Department of Biochemistry, MLN Medical College, Allahabad.
authors.forename: M K
authors.initials: MK
authors.lastname: Singh
authors.affiliation: Department of Pharmacology and Therapeutics, King George's Medical University, Lucknow.
authors.forename: P
authors.initials: P
authors.lastname: Dwivedi
authors.affiliation: Department of Cardiology King George's Medical University, Lucknow, India.
authors.forename: R
authors.initials: R
authors.lastname: Sethi
authors.affiliation: Department of Medicine King George's Medical University, Lucknow, India.
authors.forename: K
authors.initials: K
authors.lastname: Usman
authors.affiliation: Department of Pharmacology and Therapeutics, King George's Medical University, Lucknow.
authors.forename: S
authors.initials: S
authors.lastname: Khattri
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000097:blood / Q000235:genetics; D020778:Matrix Metalloproteinase 2 / Q000097:blood* / Q000235:genetics; D024821:Metabolic Syndrome / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D012306:Risk
chemical_list: C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1