title: Synthesis and Characterization of Compounds Related to Lisinopril.
abstract: Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class that is primarily used in the treatment of hypertension. During the scale-up of the lisinopril process, one unknown impurity was observed and is identified. The present work describes the origin, synthesis, characterization, and control of this impurity. This paper also describes the synthesis and characterization of three other impurities listed in the European Pharmacopoeia 8.4 (Impurity C, D, and F).
authors.affiliation: Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No:71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Telangana, 502329, India; Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, 500085, India.
authors.forename: Ambati V
authors.initials: AV
authors.lastname: Raghava Reddy
authors.affiliation: Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No:71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Telangana, 502329, India.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Garaga
authors.affiliation: Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No:71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Telangana, 502329, India.
authors.forename: Chandiran
authors.initials: C
authors.lastname: Takshinamoorthy
authors.affiliation: Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, 500085, India.
authors.forename: Andra
authors.initials: A
authors.lastname: Naidu
authors.affiliation: Affliated supervisor, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, 500085, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Dandala
keywords: Characterization; Impurities; Lisinopril; Origin; Related substances; Synthesis