title: Nonoverlapping Clinical and Mutational Patterns in Melanomas from the Female Genital Tract and Atypical Genital Nevi.
abstract: Genital melanomas (GM) are the second most common cancer of the female external genitalia and may be confused with atypical genital nevi (AGN), which exhibit atypical histological features but have benign behavior. In this study, we compared the clinical, histological, and molecular features of 19 GM and 25 AGN. We described chromosomal copy number aberrations and the mutational status of 50 oncogenes and tumor suppressor genes in both groups. Our study showed that a pigmented lesion occurring in mucosal tissue, particularly in postmenopausal women, was more likely to be a melanoma than a nevus. GM had high levels of chromosomal instability, with many copy number aberrations. Furthermore, we found a completely nonoverlapping pattern of oncogenic mutations when comparing GM and AGN. In GM, we report somatic mutations in KIT and TP53. Conversely, AGN had frequent BRAF V600E mutations, which were not seen in any of the GM. Our results show that GM and AGN have distinct clinical and molecular changes and that GM have a different mutational pattern compared with AGN.
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Oriol
authors.initials: O
authors.lastname: Yélamos
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Emily A
authors.initials: EA
authors.lastname: Merkel
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Lauren Meldi
authors.initials: LM
authors.lastname: Sholl
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Sapna M
authors.initials: SM
authors.lastname: Amin
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Christina Y
authors.initials: CY
authors.lastname: Lee
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Gerta E
authors.initials: GE
authors.lastname: Guitart
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Alexander T
authors.initials: AT
authors.lastname: Wenzel
authors.affiliation: Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Bunick
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Pedram
authors.initials: P
authors.lastname: Yazdan
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Jaehyuk
authors.initials: J
authors.lastname: Choi
authors.affiliation: Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. Electronic address: pgerami1@nm.org.
authors.forename: Pedram
authors.initials: P
authors.lastname: Gerami
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D004416:Dysplastic Nevus Syndrome / Q000235:genetics* / Q000473:pathology; D005260:Female; D005833:Genital Neoplasms, Female / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D020125:Mutation, Missense; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology