title: Curcumin Blocks Naproxen-Induced Gastric Antral Ulcerations through Inhibition of Lipid Peroxidation and Activation of Enzymatic Scavengers in Rats.
abstract: Curcumin is a polyphenol derived from the plant Curcuma longa, which is used for the treatment of diseases associated with oxidative stress and inflammation. The present study was undertaken to determine the protective effect of curcumin against naproxen-induced gastric antral ulcerations in rats. Different doses (10, 50, and 100 mg/kg) of curcumin or vehicle (curcumin, 0 mg/kg) were pretreated for 3 days by oral gavage, and then gastric mucosal lesions were caused by 80 mg/kg naproxen applied for 3 days. Curcumin significantly inhibited the naproxen-induced gastric antral ulcer area and lipid peroxidation in a dose-dependent manner. In addition, curcumin markedly increased activities of radical scavenging enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase in a dose-dependent manner. Specifically, 100 mg/kg curcumin completely protected the gastric mucosa against the loss in the enzyme, resulting in a drastic increase of activities of radical scavenging enzymes up to more than the level of untreated normal rats. Histological examination obviously showed that curcumin prevents naproxen-induced gastric antral ulceration as a result of direct protection of the gastric mucosa. These results suggest that curcumin blocks naproxen-induced gastric antral ulcerations through prevention of lipid peroxidation and activation of radical scavenging enzymes, and it may offer a potential remedy of gastric antral ulcerations.
authors.affiliation: Blue-Bio Industry RIC, Dong-Eui University, Busan 47340, Republic of Korea.
authors.forename: Jeong-Hwan
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Blue-Bio Industry RIC, Dong-Eui University, Busan 47340, Republic of Korea.
authors.forename: Soojung
authors.initials: S
authors.lastname: Jin
authors.affiliation: Blue-Bio Industry RIC, Dong-Eui University, Busan 47340, Republic of Korea.|Department of Life Science and Biotechnology, Dong-Eui University, Busan 47340, Republic of Korea.
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Kwon
authors.affiliation: Blue-Bio Industry RIC, Dong-Eui University, Busan 47340, Republic of Korea.|Department of Life Science and Biotechnology, Dong-Eui University, Busan 47340, Republic of Korea.
authors.forename: Byung Woo
authors.initials: BW
authors.lastname: Kim
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D003474:Curcumin / Q000008:administration & dosage* / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009288:Naproxen / Q000008:administration & dosage / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D009288:Naproxen; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D003474:Curcumin
keywords: Curcumin; gastric antral ulceration; lipid peroxidation; naproxen; oral gavage; radical scavenging enzymes