title: Associations of persistent organic pollutants in serum and adipose tissue with breast cancer prognostic markers.
abstract: This study aimed to evaluate associations between exposure to a group of persistent organic pollutants, measured in both adipose tissue and serum samples from breast cancer patients, and a set of tumor prognostic markers. The study population comprised 103 breast cancer patients recruited in Granada, Southern Spain. Data for tumor prognostic markers were retrieved from hospital clinical records and socio-demographic information was gathered by questionnaire. Persistent organic pollutants were quantified by gas chromatography with electron capture detection. Exposure levels were categorized in quartiles, and associations were evaluated using unconditional logistic regression. Adipose tissue HCB concentrations were associated positively with ER and PR expression (p-trends=0.044 and 0.005, respectively) and negatively with E-Cadherin and p53 expression (p-trends=0.012 and 0.027, respectively). PCB-180 adipose tissue concentrations were positively associated with HER2 expression (p-trend=0.036). Serum PCB-138 concentrations were positively associated with ER and PR expression (p-trends=0.052 and 0.042, respectively). The risk of p53 expression was higher among women in the lowest quartile of serum PCB-138 concentrations, but no significant trend was observed (p-trend=0.161). These findings indicate that human exposure to certain persistent organic pollutants might be related to breast cancer aggressiveness. We also highlight the influence on exposure assessment of the biological matrix selected, given that both serum and adipose tissue might yield relevant information on breast cancer prognosis.
authors.affiliation: Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Spain; Virgen de las Nieves University Hospital, Radiation Oncology Department, Oncology Unit, Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: jparrebola@ugr.es.
authors.forename: J P
authors.initials: JP
authors.lastname: Arrebola
authors.affiliation: Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Spain; University of Granada, Radiology and Physical Medicine Department, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Fernández-Rodríguez
authors.affiliation: Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Spain; University of Granada, Radiology and Physical Medicine Department, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Artacho-Cordón
authors.affiliation: Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Garde
authors.affiliation: Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Spain; Virgen de las Nieves University Hospital, Radiation Oncology Department, Oncology Unit, Granada, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Perez-Carrascosa
authors.affiliation: Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Spain; Virgen de las Nieves University Hospital, Radiation Oncology Department, Oncology Unit, Granada, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Linares
authors.affiliation: Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Spain; Virgen de las Nieves University Hospital, Radiation Oncology Department, Oncology Unit, Granada, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Tovar
authors.affiliation: Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Spain; Escuela Andaluza de Salud Pública, Granada, Spain.
authors.forename: B
authors.initials: B
authors.lastname: González-Alzaga
authors.affiliation: Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Spain; Virgen de las Nieves University Hospital, Radiation Oncology Department, Oncology Unit, Granada, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Expósito
authors.affiliation: Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Torne
authors.affiliation: Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain; University of Granada, Radiology and Physical Medicine Department, Spain.
authors.forename: M F
authors.initials: MF
authors.lastname: Fernández
authors.affiliation: Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain; University of Granada, Radiology and Physical Medicine Department, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Olea
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001943:Breast Neoplasms / Q000175:diagnosis*; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D010575:Pesticides / Q000097:blood / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000378:metabolism; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000097:blood / Q000378:metabolism; D011960:Receptors, Estrogen / Q000097:blood / Q000378:metabolism; D011980:Receptors, Progesterone / Q000097:blood / Q000378:metabolism
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D011078:Polychlorinated Biphenyls; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human
keywords: Adipose tissue; Breast cancer; Cancer prognosis markers; Persistent organic pollutants; Serum