title: [Hepatitis C during pregnancy, vertical transmission and new treatment possibilities].
abstract: Hepatitis C virus (HCV) infection has been recognised as a worldwide health problem. HCV is the most common cause of cirrhosis, hepatocellular carcinoma and liver transplantation. The HCV prevalence reported in pregnant women is similar to that found among the general population and does not appear to have an adverse effect on the course of pregnancy. The vertical transmission of HCV (HCV-VT) is a major route of HCV infection in children in the developed countries (>90%). The overall rate of mother-to-child transmission and chronification is about 3%-8%; however, this rate is higher for mothers who are co-infected with the human immunodeficiency virus (15-20%). In this review, we analyse the course of HCV infection during gestation, the risk factors associated with HCV-VT, the diagnostic methods/clinical monitoring recommended and the new possibilities of treatment in the era of direct-acting antiviral agents, which are essential to guide future public health efforts appropriately.
authors.affiliation: Unidad de Apoyo a la Investigación, Complejo Hospitalario Universitario de Granada e Instituto Biosanitario de Granada, ibs.GRANADA, Granada, España. Electronic address: jamunozgamez@gmail.com.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Muñoz-Gámez
authors.affiliation: Unidad de Gestión Clínica de Aparato Digestivo, Complejo Hospitalario Universitario de Granada, Departamento de Medicina de la Universidad de Granada, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, CIBERehd e Instituto Biosanitario de Granada, ibs.GRANADA, Granada, España.
authors.forename: Javier
authors.initials: J
authors.lastname: Salmerón
authors.affiliation: Unidad de Apoyo a la Investigación, Complejo Hospitalario Universitario de Granada e Instituto Biosanitario de Granada, ibs.GRANADA, Granada, España; Servicio de Pediatría, Complejo Hospitalario Universitario de Granada, Departamento de Pediatría de la Universidad de Granada y Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, CIBERehd, Granada, España.
authors.forename: Ángeles
authors.initials: Á
authors.lastname: Ruiz-Extremera
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D005060:Europe / Q000453:epidemiology; D005260:Female; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control / Q000706:statistics & numerical data; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D011295:Prenatal Care / Q000379:methods; D015995:Prevalence; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D000998:Antiviral Agents
keywords: Antivirales de acción directa; Direct-acting antiviral agents; Factores de riesgo; Gestación; Hepatitis C virus; Pregnancy; Risk factors; Transmisión vertical; Vertical transmission; Virus de la hepatitis C