title: Acquired equivalence and related memory processes in migraine without aura.
abstract: Introduction Interictal deficits of elementary visuo-cognitive functions are well documented in patients with migraine and are mostly explained in terms of neocortical hyperexcitability. It has been suggested that the basal ganglia and the hippocampi might also be affected in migraine. If so, a deterioration of learning and memory processes related to these structures is expected. Methods A visual learning paradigm thought to be capable of dissociating learning/memory processes mediated by the basal ganglia from processes mediated by the hippocampus (the Rutgers Acquired Equivalence Test) was applied to a group of patients with migraine without aura and to age- and sex-matched controls. Results Patients with migraine showed a significantly poorer performance in both main phases of the test and the deficit in the phase considered to be dependent on the hippocampi was especially marked. Conclusions These results can be interpreted as behavioural support for findings that have suggested the involvement of the basal ganglia and the hippocampi in migraine, but further research is needed to clarify these findings.
authors.affiliation: 1 University of Szeged, Faculty of Medicine, Department of Physiology, Szeged, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Öze
authors.affiliation: 1 University of Szeged, Faculty of Medicine, Department of Physiology, Szeged, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Nagy
authors.affiliation: 1 University of Szeged, Faculty of Medicine, Department of Physiology, Szeged, Hungary.
authors.forename: György
authors.initials: G
authors.lastname: Benedek
authors.affiliation: 1 University of Szeged, Faculty of Medicine, Department of Physiology, Szeged, Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Bodosi
authors.affiliation: 2 Nyírö Gyula Hospital, Laboratory for Perception and Cognition and Clinical Neuroscience, Budapest, Hungary.
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Kéri
authors.affiliation: 3 Bács-Kiskun County Hospital, Neurology and Stroke Department, Kecskemét, Hungary.
authors.forename: Éva
authors.initials: É
authors.lastname: Pálinkás
authors.affiliation: 3 Bács-Kiskun County Hospital, Neurology and Stroke Department, Kecskemét, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Bihari
authors.affiliation: 2 Nyírö Gyula Hospital, Laboratory for Perception and Cognition and Clinical Neuroscience, Budapest, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Braunitzer
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D020326:Migraine without Aura / Q000000981:diagnostic imaging* / Q000523:psychology*; D010775:Photic Stimulation / Q000379:methods*; D055815:Young Adult
keywords: Migraine; acquired equivalence; basal ganglia; hippocampus; learning