title: Serum high-density lipoprotein correlates with serum apolipoprotein M and A5 in obstructive sleep apnea hypopnea syndrome.
abstract: OBJECTIVE
  The purpose of this study was to investigate the correlation between serum levels of serum apolipoprotein M (ApoM), A5 (ApoA5), and high-density lipoprotein (HDL) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and study the effects of nasal continuous positive airway pressure treatment on these serum biomarkers.
  
  
  METHODS
  Thirty OSAHS patients and 15 non-OSAHS probands as control were selected for the study. Serum HDL, ApoM, and ApoA5 levels in two groups were detected; differences and association among them were analyzed. Patients with moderate and severe OSAHS underwent 3-month auto-continuous positive airway pressure treatment, and a comparative study was conducted to investigate the changes in blood lipids, serum ApoM, and ApoA5.
  
  
  RESULTS
  In comparison to the control group, the HDL, ApoM, and ApoA5 serum levels were lower (P < 0.05). HDL was positively correlated to ApoM and ApoA5 (P < 0.001), and ApoM was positively correlated to ApoA5 (r = 0.536, P < 0.001). HDL, ApoM, and ApoA5 were significantly increased in the patients of moderate and severe OSAHS after auto-continuous positive airway pressure treatment for 3 months (P < 0.05).
  
  
  CONCLUSIONS
  The HDL level was significantly lower in OSAHS patients. The decrease in serum ApoM and ApoA5 in OSAHS patients was correlated to the severity of OSAHS and HDL levels. Auto-continuous positive airway pressure treatment increased serum levels of ApoM, ApoA5, and HDL in OSAHS patients.
authors.affiliation: Department of Gerontology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
authors.forename: Shengyu
authors.initials: S
authors.lastname: Tan
authors.affiliation: Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
authors.forename: Xianling
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Gerontology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Gerontology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Cardiovascularology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
authors.forename: Shenghua
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. gaoyawensci@126.com.
authors.forename: Yawen
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000328:Adult; D000072040:Apolipoprotein A-V / Q000097:blood*; D000075243:Apolipoproteins M / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017286:Polysomnography; D012189:Retrospective Studies; D012307:Risk Factors; D012815:Signal Processing, Computer-Assisted; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000628:therapy; D013223:Statistics as Topic
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D000075243:Apolipoproteins M; D015415:Biomarkers; D008075:Lipoproteins, HDL
keywords: Apolipoprotein A5; Apolipoprotein M; High-density lipoprotein; Nasal continuous positive airway pressure treatment; Obstructive sleep apnea hypopnea syndrome