title: AMBULATORY BLOOD PRESSURE PATTERNS IN PATIENTS WITH RETINAL VEIN OCCLUSION.
abstract: OBJECTIVE
  Failure of blood pressure (BP) to dip during sleep (nondipper pattern) is associated with cardiovascular disease and stroke. The prevalence and degree of nondipping and masked hypertension in patients with retinal vein occlusion (RVO), which is associated with stroke, has not been previously examined.
  
  
  METHODS
  We measured clinic and 24-hour ambulatory BPs in 22 patients with RVO and 20 control participants without known eye disease matched by age and sex. Mean BP dipping, defined as the ratio of difference in mean awake and sleep systolic BPs to mean awake systolic BP, and masked and nocturnal hypertension were compared between groups.
  
  
  RESULTS
  Mean 24-hour ambulatory BP was 144/79 mmHg among those with RVO and 136/77 mmHg among controls. Patients with RVO had an almost 2-fold higher prevalence of nondipping pattern (80.8% [95% confidence interval, 52.8-94.1] vs. 50.4% [95% confidence interval, 26.1-74.5]; P = 0.008). Average sleep systolic BP dip in patients with RVO was 6.1% versus 11.9% in controls (P = 0.004). More patients with RVO had masked hypertension by ambulatory BPs than controls (71% vs. 50%), but this difference was not statistically significant.
  
  
  CONCLUSIONS
  Our data suggest an association between RVO and nondipper BP pattern. Ambulatory BP monitoring may be useful in the evaluation of patients with RVO by identifying those who may benefit from more aggressive BP control.
authors.affiliation: *Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland; †Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; ‡MD-MPH Program, UNC School of Medicine and Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; §Hypertension Research Program, Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; ¶Department of Ophthalmology, University of Kansas School of Medicine, Prairie Village, Kansas; **Duke Eye Center, Duke University Medical Center, Durham, North Carolina; and ††North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas.
authors.forename: Vishal N
authors.initials: VN
authors.lastname: Rao
authors.forename: J Niklas
authors.initials: JN
authors.lastname: Ulrich
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Viera
authors.forename: Anna
authors.initials: A
authors.lastname: Parlin
authors.forename: Sharon
authors.initials: S
authors.lastname: Fekrat
authors.forename: Sai H
authors.initials: SH
authors.lastname: Chavala
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D016022:Case-Control Studies; D002940:Circadian Rhythm / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012170:Retinal Vein Occlusion / Q000503:physiopathology*