title: Radon Exposure and the Definition of Low Doses-The Problem of Spatial Dose Distribution.
abstract: Investigating the health effects of low doses of ionizing radiation is considered to be one of the most important fields in radiological protection research. Although the definition of low dose given by a dose range seems to be clear, it leaves some open questions. For example, the time frame and the target volume in which absorbed dose is measured have to be defined. While dose rate is considered in the current system of radiological protection, the same cancer risk is associated with all exposures, resulting in a given amount of energy absorbed by a single target cell or distributed among all the target cells of a given organ. However, the biological effects and so the health consequences of these extreme exposure scenarios are unlikely to be the same. Due to the heterogeneous deposition of radon progeny within the lungs, heterogeneous radiation exposure becomes a practical issue in radiological protection. While the macroscopic dose is still within the low dose range, local tissue doses on the order of Grays can be reached in the most exposed parts of the bronchial airways. It can be concluded that progress in low dose research needs not only low dose but also high dose experiments where small parts of a biological sample receive doses on the order of Grays, while the average dose over the whole sample remains low. A narrow interpretation of low dose research might exclude investigations with high relevance to radiological protection. Therefore, studies important to radiological protection should be performed in the frame of low dose research even if the applied doses do not fit in the dose range used for the definition of low doses.
authors.affiliation: *Environmental Physics Department, Centre for Energy Research, Hungarian Academy of Sciences.
authors.forename: Balázs G
authors.initials: BG
authors.lastname: Madas
mesh_terms: D000396:Air Pollutants, Radioactive / Q000032:analysis*; D016902:Air Pollution, Indoor / Q000032:analysis*; D016477:Artifacts; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D011829:Radiation Dosage; D000069079:Radiation Exposure / Q000032:analysis*; D011834:Radiation Monitoring / Q000379:methods*; D011835:Radiation Protection / Q000379:methods; D011886:Radon / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D062211:Spatio-Temporal Analysis
chemical_list: D000396:Air Pollutants, Radioactive; D011886:Radon