title: Reporter Systems to Study Cancer Stem Cells.
abstract: Cancer stem cells have been identified in primary tumors, patient derived xenografts, and established cancer cell lines. The development of reporters has enabled investigators to rapidly enrich for these cells and more importantly track these cells in real time. Here we describe the current state of the reporter field and their use and limitations in multiple cancers.
authors.affiliation: Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NC 10, Cleveland, OH, 44195, USA.
authors.forename: Caner
authors.initials: C
authors.lastname: Saygin
authors.affiliation: Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NC 10, Cleveland, OH, 44195, USA.|Medicine Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Samour
authors.affiliation: Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NC 10, Cleveland, OH, 44195, USA.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Chumakova
authors.affiliation: Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NC 10, Cleveland, OH, 44195, USA.
authors.forename: Awad
authors.initials: A
authors.lastname: Jarrar
authors.affiliation: Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NC 10, Cleveland, OH, 44195, USA.|Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44195, USA.|Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH, 44195, USA.|Case Comprehensive Cancer Center, Cleveland, OH, 44106, USA.
authors.forename: Justin D
authors.initials: JD
authors.lastname: Lathia
authors.affiliation: Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NC 10, Cleveland, OH, 44195, USA. reizeso@ccf.org.|Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44195, USA. reizeso@ccf.org.|Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH, 44195, USA. reizeso@ccf.org.|Case Comprehensive Cancer Center, Cleveland, OH, 44106, USA. reizeso@ccf.org.
authors.forename: Ofer
authors.initials: O
authors.lastname: Reizes
mesh_terms: D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D017930:Genes, Reporter / Q000235:genetics*; D006801:Humans; D008967:Molecular Biology / Q000379:methods*; D000071317:Nanog Homeobox Protein / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000378:metabolism* / Q000473:pathology
chemical_list: D000071317:Nanog Homeobox Protein
keywords: Cancer stem cells; NANOG; Pluripotency transcription factor; Reporter; Tumor heterogeneity