title: [Influence of Acetylcysteine on Cytogenetic Effects of Etoposide in Mouse Oocytes].
abstract: The influence of N-acetylcysteine (ACC) on the cytogenetic effects of etoposide in F1 CBA x C57BL/6 mice was studied. Etoposide introduced intraperitoneally in doses of 10, 20, 40, and 60 mg/kg has a dose-dependent clastogenic activity and has an aneugenic effect with the induction of mainly hypohaploid oocytes. ACC significantly decreases the aneugenic and clastogenic activity of etoposide (20 mg/kg) in oocytes of 6-, 9-, and 12-week-old mice during triple introduction at a dose 200 mg/kg per os. The most pronounced anticlastogenic ACC activity (an 80% decrease) was registered in 9-week-old females; a 100% decrease in aneugenesis was detected in 6-week-old female mice.
authors.forename: K L
authors.initials: KL
authors.lastname: Pligina
authors.forename: A K
authors.initials: AK
authors.lastname: Zhanataev
authors.forename: A V
authors.initials: AV
authors.lastname: Kulakova
authors.forename: Z V
authors.initials: ZV
authors.lastname: Chaika
authors.forename: A D
authors.initials: AD
authors.lastname: Durnev
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage*; D000818:Animals; D002869:Chromosome Aberrations / Q000187:drug effects*; D005047:Etoposide / Q000633:toxicity; D005260:Female; D051379:Mice; D016296:Mutagenesis / Q000187:drug effects*; D009153:Mutagens / Q000633:toxicity; D009865:Oocytes / Q000187:drug effects* / Q000254:growth & development
chemical_list: D009153:Mutagens; D005047:Etoposide; D000111:Acetylcysteine