title: Fatal hepatocellular carcinoma presenting with oral metastasis in a patient with synchronic primary malignancies of prostate and liver.
abstract: Hepatocellular carcinoma (HCC) is the most frequent type of liver cancer and its occurrence in the oral cavity as a metastatic neoplasm is a rare event. We describe a fatal case of HCC with oral metastasis in a patient firstly diagnosed with prostatic and hepatic carcinomas. The histopathological examination revealed a hepatocyte-like tumour cells arranged in organoid structures as well as positivity to cytokeratin 8 and Hep Par 1. The present findings highlight the importance of a complete medical evaluation of the patient to identify possible oral repercussions of primary diseases.
authors.affiliation: Laboratory of Molecular Pathology, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Maria Fernanda Setúbal Destro
authors.initials: MFSD
authors.lastname: Rodrigues
authors.affiliation: Laboratory of Molecular Pathology, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Carina Magalhães
authors.initials: CM
authors.lastname: Esteves
authors.affiliation: Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Márcio Augusto
authors.initials: MA
authors.lastname: de Oliveira
authors.affiliation: Laboratory of Molecular Pathology, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Nathália Paiva
authors.initials: NP
authors.lastname: de Andrade
authors.affiliation: Laboratory of Surgical Pathology, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Bruno Tavares
authors.initials: BT
authors.lastname: Sedassari
authors.affiliation: General Pathology, Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Fernando Augusto
authors.initials: FA
authors.lastname: Soares
authors.affiliation: Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Fabio Daumas
authors.initials: FD
authors.lastname: Nunes
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000556:secondary*; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000556:secondary*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*
keywords: hepatocellular carcinoma; immunohistochemistry; oral metastasis