title: Should Pneumococcal Vaccines Eliminate Nasopharyngeal Colonization?
abstract: Streptococcus pneumoniae remains an important human pathogen. For more than 100 years, there have been vaccine efforts to prevent pneumococcal infection. The pneumococcal conjugate vaccines have significantly reduced invasive disease. However, these vaccines have changed pneumococcal ecology within the human nasopharynx. We suggest that elimination of the pneumococcus from the human nasopharynx can have consequences that should be considered as the next generation of pneumococcal vaccines is developed.
authors.affiliation: Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, Mississippi, USA lmcdaniel@umc.edu.
authors.forename: Larry S
authors.identifier: 0000-0002-1649-7563
authors.initials: LS
authors.lastname: McDaniel
authors.affiliation: Veterans Affairs Medical Center, Jackson, Mississippi, USA.
authors.forename: Edwin
authors.initials: E
authors.lastname: Swiatlo
mesh_terms: D002353:Carrier State / Q000382:microbiology / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D009305:Nasopharynx / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000382:microbiology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000502:physiology*; D018074:Vaccines, Conjugate
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate