title: Deciphering signaling networks in osteosarcoma pathobiology.
abstract: Osteosarcoma is the most frequent type of primary bone tumors among children and adolescents. During the past years, little progress has been made regarding prognosis of osteosarcoma patients, especially for those with metastatic disease. Genomic instability and gene alterations are common, but current data do not reveal a consistent and repeatable pattern of osteosarcoma development, thus paralleling the tumor's high heterogeneity. Critical signal transduction pathways have been implicated in osteosarcoma pathobiology and are being evaluated as therapeutic targets, including receptor activator for nuclear factor-κB (RANK), Wnt, Notch, phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin, and mechanotransduction pathways. Herein, we recapitulate and discuss recent advances in the context of molecular mechanisms and signaling networks that contribute to osteosarcoma progression and metastasis, towards patient-tailored and novel-targeted treatments.
authors.affiliation: Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Adamopoulos
authors.affiliation: Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
authors.forename: Antonios N
authors.initials: AN
authors.lastname: Gargalionis
authors.affiliation: Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
authors.forename: Efthimia K
authors.initials: EK
authors.lastname: Basdra
authors.affiliation: Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece papavas@med.uoa.gr.
authors.forename: Athanasios G
authors.initials: AG
authors.lastname: Papavassiliou
mesh_terms: D000818:Animals; D053263:Gene Regulatory Networks; D006801:Humans; D012516:Osteosarcoma / Q000473:pathology* / Q000503:physiopathology*; D015398:Signal Transduction
keywords: Osteosarcoma; activator protein-1; mammalian target of rapamycin; mechanotransduction; nuclear factor-κB; signal transduction