title: Damage limitation.
abstract: A spring-loaded mechanism can explain the activation process for a protein that has a crucial role in maintaining the genomic integrity of immature eggs cells.
authors.affiliation: Medical Research Council Toxicology Unit, Leicester University, Leicester, United Kingdom.
authors.forename: Ivano
authors.initials: I
authors.lastname: Amelio
authors.affiliation: Medical Research Council Toxicology Unit, Leicester University, Leicester, United Kingdom.|Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Gerry
authors.initials: G
authors.lastname: Melino
mesh_terms: D004249:DNA Damage; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins
keywords: DNA damage; E. coli; biophysics; cell biology; kinetically trapped state, p63; mouse; oocytes; p53 family proteins; quality control; spring-loaded activation; structural biology