title: A Review of Psoriasis, Therapies, and Suicide.
abstract: Many chronic medical disorders are associated with psychiatric morbidity. Yet the psychological burden of these disorders often goes unnoticed. In dermatology, psoriasis has a higher association with psychiatric illness, including depression and suicide risk, compared with many other conditions. Studies suggest that effective treatment of psoriasis results in the improvement of psychiatric morbidity, particularly depression and anxiety. New biologic treatments for psoriasis may offer help beyond clearing of the skin in these patients and may lead to a reduction of psychiatric morbidity. Although concerns have been raised regarding the potential link between interleukin-17R blockade in the treatment of psoriasis and suicide, current literature provides no evidence to support this association.
authors.affiliation: Skin Centre for Dermatology, Peterborough, ON, Canada Probity Medical Research, Waterloo, ON, Canada mgooderham@centrefordermatology.com.
authors.forename: Melinda
authors.initials: M
authors.lastname: Gooderham
authors.affiliation: Skin Centre for Dermatology, Peterborough, ON, Canada.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Gavino-Velasco
authors.affiliation: Skin Centre for Dermatology, Peterborough, ON, Canada.
authors.forename: Cole
authors.initials: C
authors.lastname: Clifford
authors.affiliation: Skin Centre for Dermatology, Peterborough, ON, Canada.
authors.forename: Alex
authors.initials: A
authors.lastname: MacPherson
authors.affiliation: Probity Medical Research, Waterloo, ON, Canada.
authors.forename: Flora
authors.initials: F
authors.lastname: Krasnoshtein
authors.affiliation: K. Papp Clinical Research, Waterloo, ON, Canada Probity Medical Research, Waterloo, ON, Canada.
authors.forename: Kim
authors.initials: K
authors.lastname: Papp
mesh_terms: D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007378:Interleukins / Q000037:antagonists & inhibitors*; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology / Q000523:psychology*; D013405:Suicide
chemical_list: D007155:Immunologic Factors; D007378:Interleukins
keywords: psoriasis; suicide