title: Programmable biomaterials for dynamic and responsive drug delivery.
abstract: Biomaterials are continually being designed that enable new methods for interacting dynamically with cell and tissues, in turn unlocking new capabilities in areas ranging from drug delivery to regenerative medicine. In this review, we explore some of the recent advances being made in regards to programming biomaterials for improved drug delivery, with a focus on cancer and infection. We begin by explaining several of the underlying concepts that are being used to design this new wave of drug delivery vehicles, followed by examining recent materials systems that are able to coordinate the temporal delivery of multiple therapeutics, dynamically respond to changing tissue environments, and reprogram their bioactivity over time.
authors.affiliation: Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
authors.forename: Anna
authors.initials: A
authors.lastname: Stejskalová
authors.affiliation: Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
authors.forename: Mehrdad T
authors.initials: MT
authors.lastname: Kiani
authors.affiliation: Department of Bioengineering, Imperial College London, London SW7 2AZ, UK b.almquist@imperial.ac.uk.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Almquist
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001672:Biocompatible Materials / Q000008:administration & dosage*; D003141:Communicable Diseases / Q000188:drug therapy*; D016503:Drug Delivery Systems / Q000379:methods*; D055808:Drug Discovery / Q000639:trends; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001672:Biocompatible Materials
keywords: Bionanoscience; bacteria; biomaterials; cancer; drug delivery; nanoparticles