title: CLIP-COSY: A Clean In-Phase Experiment for the Rapid Acquisition of COSY-type Correlations.
abstract: The COSY experiment is an essential homonuclear 2D NMR experiment for the assignment of resonances. Its multiplet line shape, however, is often overly complicated, potentially leads to signal intensity losses, and is responsible for long minimum overall acquisition times. Herein, we present CLIP-COSY, a COSY-type experiment yielding clean in-phase peaks. It can be recorded within a few minutes and benefits from enhanced signal intensities for most cross-peaks. In combination with non-uniform sampling, the experiment times can be further reduced, and the in-phase multiplets enable the application of modern homonuclear decoupling techniques in both dimensions. As antiphase cancelations are avoided, CLIP-COSY can also be applied to macromolecules and other samples with broadened lines.
authors.affiliation: Institut für Organische Chemie and Institut für Biologische, Grenzflächen 4-Magnetische Resonanz, Karlsruher Institut für Technologie (KIT), Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.
authors.forename: Martin R M
authors.initials: MR
authors.lastname: Koos
authors.affiliation: Institut für Organische Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747, Garching, Germany.
authors.forename: Grit
authors.initials: G
authors.lastname: Kummerlöwe
authors.affiliation: Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Technische Universität Darmstadt, Alarich-Weiss-Strasse 16, 64287, Darmstadt, Germany.
authors.forename: Lukas
authors.identifier: 0000-0002-3530-8000
authors.initials: L
authors.lastname: Kaltschnee
authors.affiliation: Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Technische Universität Darmstadt, Alarich-Weiss-Strasse 16, 64287, Darmstadt, Germany.
authors.forename: Christina M
authors.identifier: 0000-0001-7876-536X
authors.initials: CM
authors.lastname: Thiele
authors.affiliation: Institut für Organische Chemie and Institut für Biologische, Grenzflächen 4-Magnetische Resonanz, Karlsruher Institut für Technologie (KIT), Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany. Burkhard.Luy@kit.edu.
authors.forename: Burkhard
authors.identifier: 0000-0001-9580-6397
authors.initials: B
authors.lastname: Luy
keywords: COSY; NMR spectroscopy; analytical methods; perfect echo; rapid acquisition