title: Lycium barbarum Polysaccharide Mediated the Antidiabetic and Antinephritic Effects in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats via Regulation of NF-κB.
abstract: Lycium barbarum, extensively utilized as a medicinal plant in China for years, exhibits antitumor, immunoregulative, hepatoprotective, and neuroprotective properties. The present study aims to investigate the hyperglycemic and antidiabetic nephritic effects of polysaccharide which is separated from Lycium barbarum (LBPS) in high-fat diet-streptozotocin- (STZ-) induced rat models. The reduced bodyweight and enhanced blood glucose concentration in serum were observed in diabetic rats, and they were significantly normalized to the healthy level by 100 mg/kg of metformin (Met) and LBPS at doses of 100, 250, and 500 mg/kg. LBPS inhibited albuminuria and blood urea nitrogen concentration and serum levels of inflammatory factors including IL-2, IL-6, TNF-α, IFN-α, MCP-1, and ICAM-1 compared with diabetic rats, and it indicates the protection on renal damage. Furthermore, the activities of SOD and GSH-Px in serum were enhanced strikingly by LBPS which suggests its antioxidation effects. LBPS, compared with nontreated diabetic rats, inhibited the expression of phosphor-nuclear factors kappa B (NF-κB) and inhibitor kappa B alpha in kidney tissues. Collectively, LBPS possesses antidiabetic and antinephritic effects related to NF-κB-mediated antioxidant and antiinflammatory activities.
authors.affiliation: Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212001, China.
authors.forename: Mingzhao
authors.initials: M
authors.lastname: Du
authors.affiliation: Faculty of Medicine, Changchun Medical College, Changchun 130013, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Hu
authors.affiliation: Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212001, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Kou
authors.affiliation: Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212001, China.
authors.forename: Baohai
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212001, China.
authors.forename: Chaopu
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001786:Blood Glucose / Q000276:immunology; D016207:Cytokines / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*; D004041:Dietary Fats; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D008297:Male; D008687:Metformin / Q000008:administration & dosage; D016328:NF-kappa B / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012076:Renal Agents / Q000008:administration & dosage; D013311:Streptozocin; D016896:Treatment Outcome; D014508:Urea / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D001786:Blood Glucose; D016207:Cytokines; D004041:Dietary Fats; D004365:Drugs, Chinese Herbal; D016328:NF-kappa B; D012076:Renal Agents; C500223:lycium barbarum polysaccharide; D013311:Streptozocin; D014508:Urea; D008687:Metformin