title: The influence of family pattern abnormalities in the early stages of life on the course of inflammatory bowel diseases.
abstract: Crohn's disease (CD) and ulcerative colitis (UC) belong to the group of inflammatory bowel diseases (IBD), chronic immune mediated diseases of the gastrointestinal (GI) tract with significant negative impact on patients' quality of life. CD and UC are related with the development of chronic inflammatory lesions in the GI tract, causing digestive and absorption disorders. Typical symptoms of IBD are: abdominal pain, vomiting, diarrhea, rectal bleeding, and weight loss. In addition, IBD are often associated with the extraintestinal manifestations, including arthritis and dermatoses. While the cause of IBD is still not fully understood, the psychological aspects are regarded as possible trigger factors. Moreover, most recent studies suggest that family pattern abnormalities associated with stress at the early stages of life may strongly affect health balance. In this paper, the most relevant studies focusing on the association between early life stress and IBD, found in MEDLINE, Cochrane Library and EMBASE are discussed. Possible effects of the early life stress on IBD progression and response to undertaken therapies are analyzed.
authors.affiliation: Department of Gastroenterology, Medical University of Lodz, Łódź, Poland; Department of Biochemistry, Medical University of Lodz, Łódź, Poland. Electronic address: dr.mwlodarczyk@gmail.com.
authors.forename: Marcin
authors.initials: M
authors.lastname: Włodarczyk
authors.affiliation: Department of Gastroenterology, Medical University of Lodz, Łódź, Poland; Department of Biochemistry, Medical University of Lodz, Łódź, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Sobolewska-Włodarczyk
authors.affiliation: Department of Gastroenterology, Medical University of Lodz, Łódź, Poland.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Stec-Michalska
authors.affiliation: Department of Biochemistry, Medical University of Lodz, Łódź, Poland.
authors.forename: Jakub
authors.initials: J
authors.lastname: Fichna
authors.affiliation: Department of Gastroenterology, Medical University of Lodz, Łódź, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Wiśniewska-Jarosińska
mesh_terms: D000818:Animals; D018450:Disease Progression; D054541:Family Conflict / Q000523:psychology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D011788:Quality of Life; D013315:Stress, Psychological / Q000150:complications / Q000523:psychology*
keywords: Crohn's disease; Family pattern; Inflammatory bowel diseases; Ulcerative colitis