title: The Relieving Effects of BrainPower Advanced, a Dietary Supplement, in Older Adults with Subjective Memory Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial.
abstract: Subjective memory complaints (SMCs) are common in older adults that can often predict further cognitive impairment. No proven effective agents are available for SMCs. The effect of BrainPower Advanced, a dietary supplement consisting of herbal extracts, nutrients, and vitamins, was evaluated in 98 volunteers with SMCs, averaging 67 years of age (47-88), in a randomized, double-blind, placebo-controlled trial. Subjective hypomnesis/memory loss (SML) and attention/concentration deficits (SAD) were evaluated before and after 12-week supplementation of BrainPower Advanced capsules (n = 47) or placebo (n = 51), using a 5-point memory questionnaire (1 = no/slight, 5 = severe). Objective memory function was evaluated using 3 subtests of visual/audio memory, abstraction, and memory recall that gave a combined total score. The BrainPower Advanced group had more cases of severe SML (severity ⩾ 3) (44/47) and severe SAD (43/47) than the placebo group (39/51 and 37/51, < 0.05, < 0.05, resp.) before the treatment. BrainPower Advanced intervention, however, improved a greater proportion of the severe SML (29.5%)(13/44) (P < 0.01) and SAD (34.9%)(15/43)(P < 0.01) than placebo (5.1% (2/39) and 13.5% (5/37), resp.). Thus, 3-month BrainPower Advanced supplementation appears to be beneficial to older adults with SMCs.
authors.affiliation: Department of Community Health and Family Medicine, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Jingfen
authors.initials: J
authors.lastname: Zhu
authors.affiliation: School of Public Health, Shanghai University of TCM, Shanghai 201203, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Shi
authors.affiliation: Si-Tang Community Health Service Center of Shanghai, Shanghai 200431, China.
authors.forename: Su
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Emergency Medicine, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Dai
authors.affiliation: Department of Community Health and Family Medicine, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Shen
authors.affiliation: Department of Community Health and Family Medicine, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Southern California Kaiser Sunset, 4867 Sunset Boulevard, Los Angeles, CA 90027, USA.
authors.forename: Pingping
authors.initials: P
authors.lastname: Gu
authors.affiliation: Department of Research, DRM Resources, 1683 Sunflower Avenue, Costa Mesa, CA 92626, USA.
authors.forename: Mina
authors.initials: M
authors.lastname: Shariff
authors.affiliation: Department of Research, DRM Resources, 1683 Sunflower Avenue, Costa Mesa, CA 92626, USA.
authors.forename: Tuong
authors.initials: T
authors.lastname: Nguyen
authors.affiliation: Maryland Population Research Center, University of Maryland, College Park, MD 20742, USA.
authors.forename: Yeats
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Jianyu
authors.initials: J
authors.lastname: Rao
authors.affiliation: Imaging Institute of Rehabilitation and Development of Brain Function, North Sichuan Medical University, Nanchong Central Hospital, Nanchong 637000, China; Lotus Biotech.com LLC, John Hopkins University-MCC, 9601 Medical Center Drive, Rockville, MD 20850, USA.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Xing