title: Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China.
abstract: The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.
authors.affiliation: Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yu
authors.affiliation: The Center of Clinical Diagnosis Laboratory, 302 Hospital of PLA, Beijing, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Qu
authors.affiliation: Department of Laboratory Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Shan
authors.affiliation: Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Huang
authors.affiliation: Center of Medical Laboratory, the General Hospital of Ningxia Medical University, Yinchuan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
authors.affiliation: Department of Laboratory Medicine, The Traditional Chinese Medical Hospital of Guangdong, Guangzhou, Guangdong, China.
authors.forename: Cha
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Aiqing
authors.initials: A
authors.lastname: Li
authors.affiliation: Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Minhui
authors.initials: M
authors.lastname: Miao
authors.affiliation: Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: The Center of Clinical Diagnosis Laboratory, 302 Hospital of PLA, Beijing, China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Bao
authors.affiliation: Department of Laboratory Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
authors.forename: Yunmin
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
authors.forename: Kalyan D
authors.initials: KD
authors.lastname: Chavda
authors.affiliation: Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: Yi-Wei
authors.identifier: 0000-0003-4888-6771
authors.initials: YW
authors.lastname: Tang
authors.affiliation: Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
authors.forename: Barry N
authors.initials: BN
authors.lastname: Kreiswirth
authors.affiliation: Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China hong_du@126.com Chen11@njms.rutgers.edu.
authors.forename: Hong
authors.initials: H
authors.lastname: Du
authors.affiliation: Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA hong_du@126.com Chen11@njms.rutgers.edu.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D002681:China; D002876:Chromosomes, Bacterial / Q000235:genetics; D003091:Colistin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D006761:Hospitals; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D003091:Colistin