title: [Estrogen receptor alpha in obesity and diabetes].
abstract: Estradiol (E2) is an important hormone in reproductive physiology, cardiovascular, skeletal and in the central nervous system (CNS). In human and rodents, E2 and its receptors are involved in the control of energy and glucose metabolism in health and metabolic diseases. The estrogen receptor (ER) belongs to the superfamily of nuclear receptors (NR), which are transcription factors that regulate gene expression. Three ER, ER-alpha, ER-beta and the G protein-coupled ER (GPER; also called GPR30) in tissues are involved in glucose and lipid homeostasis. Also, it may have important implications for risk factors associated with metabolic syndrome (MS), insulin resistance (IR), obesity and type 2 diabetes (T2D).
authors.affiliation: Laboratorio de Investigación en Epidemiología Clínica y Molecular, Unidad Académica de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, México. mcruzl@yahoo.com.
authors.forename: José Ángel
authors.initials: JÁ
authors.lastname: Cahua-Pablo
authors.forename: Eugenia
authors.initials: E
authors.lastname: Flores-Alfaro
authors.forename: Miguel
authors.initials: M
authors.lastname: Cruz
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D047629:Estrogen Receptor beta / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D024821:Metabolic Syndrome / Q000209:etiology / Q000378:metabolism; D009765:Obesity / Q000209:etiology / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004958:Estradiol
keywords: Diabetes mellitus; Estradiol; Estrogens; Obesity