title: [Therapy of basal cell carcinoma].
abstract: Basal cell carcinoma (BCC) represents the most common malignant skin tumour in fair-skinned people. Despite low metastatic potential, BCC can cause decisive tissue destruction and disfigurement by invasive growth. In addition to clinical and histologic diagnosis modern imaging techniques as optical coherence tomography and confocal laser microscopy have been introduced. BCCs with aggressive growth pattern and/or increased risk of relapse are preferentially treated surgically. For superficial BCCs various topical treatments and photodynamic therapy are available. Inhibitors of the sonic hedgehog pathway have been approved for symptomatic treatment of metastatic BCC and locally advanced BCC inappropriate for surgery or radiotherapy. Detailed knowledge of the clinical spectrum of BCC and an appropriate choice of therapy are mandatory for the successful treatment of BCC.
authors.affiliation: Klinik für Dermatologie, Ruhr-Universität Bochum, Gudrunstr. 56, 44791, Bochum, Deutschland.|CentroDerm Klinik, Heinz-Fangman-Str. 57, 42287, Wuppertal, Deutschland.
authors.forename: L
authors.initials: L
authors.lastname: Schmitz
authors.affiliation: CentroDerm Klinik, Heinz-Fangman-Str. 57, 42287, Wuppertal, Deutschland. t.dirschka@centroderm.de.|Fakultät für Gesundheit, Universität Witten-Herdecke, Alfred-Herrhausen-Str. 50, 58445, Witten, Deutschland. t.dirschka@centroderm.de.
authors.forename: T
authors.initials: T
authors.lastname: Dirschka
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy / Q000379:methods*; D003131:Combined Modality Therapy / Q000379:methods; D062109:Dermatologic Surgical Procedures / Q000379:methods*; D019317:Evidence-Based Medicine; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D017319:Photosensitizing Agents
keywords: Micrographic surgery; Optical coherence tomography; Photodynamic therapy; Sonic hedgehog pathway; Treatment algorithm