title: Signal enhancement in ligand-receptor interactions using dynamic polymers at quartz crystal microbalance sensors.
abstract: The signal enhancement properties of QCM sensors based on dynamic, biotinylated poly(acrylic acid) brushes has been studied in interaction studies with an anti-biotin Fab fragment. The poly(acrylic acid) sensors showed a dramatic increase in signal response with more than ten times higher signal than the carboxyl-terminated self-assembled monolayer surface.
authors.affiliation: KTH - Royal Institute of Technology, Department of Chemistry, Teknikringen 30, S-10044 Stockholm, Sweden. ramstrom@kth.se and Attana AB, Björnnäsvägen 21, S-11419 Stockholm, Sweden.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Dunér
authors.affiliation: Attana AB, Björnnäsvägen 21, S-11419 Stockholm, Sweden and Uppsala University, Ångström Laboratory, Solid State Electronics, P.O. Box 534, S-75121 Uppsala, Sweden.
authors.forename: Henrik
authors.initials: H
authors.lastname: Anderson
authors.affiliation: Attana AB, Björnnäsvägen 21, S-11419 Stockholm, Sweden.
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Pei
authors.affiliation: Attana AB, Björnnäsvägen 21, S-11419 Stockholm, Sweden.
authors.forename: Björn
authors.initials: B
authors.lastname: Ingemarsson
authors.affiliation: Attana AB, Björnnäsvägen 21, S-11419 Stockholm, Sweden.
authors.forename: Teodor
authors.initials: T
authors.lastname: Aastrup
authors.affiliation: KTH - Royal Institute of Technology, Department of Chemistry, Teknikringen 30, S-10044 Stockholm, Sweden. ramstrom@kth.se.
authors.forename: Olof
authors.initials: O
authors.lastname: Ramström
mesh_terms: D015374:Biosensing Techniques; D001710:Biotin; D007140:Immunoglobulin Fab Fragments / Q000737:chemistry*; D008024:Ligands; D011108:Polymers; D058525:Quartz Crystal Microbalance Techniques
chemical_list: D007140:Immunoglobulin Fab Fragments; D008024:Ligands; D011108:Polymers; D001710:Biotin