title: Characterization of the gene encoding a fibrinogen-related protein expressed in Crassostrea gigas hemocytes.
abstract: Four exons of the CgFrep1 gene (3333 bp long) encode a putative fibrinogen-related protein (324 aa) bearing a single C-terminal FBG domain. Transcripts of the gene obtained from hemocytes of different Pacific oysters show prominent individual variation based on SNP and indels of tandem repeats resulted in polymorphism of N-terminus of the putative CgFrep1 polypeptide. The polypeptide chain bears N-terminal coiled-coil region potentially acting as inter-subunit interface in the protein oligomerization. It is suggested that CgFrep1 gene encodes the oligomeric lectin composed of at least two subunits.
authors.affiliation: Saint-Petersburg State University, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Skazina
authors.affiliation: Institute of Evolutionary Physiology and Biochemistry (IEPHB RAS), Saint-Petersburg, Russia. Electronic address: agorbushin@gmail.com.
authors.forename: A M
authors.initials: AM
authors.lastname: Gorbushin
mesh_terms: D000818:Animals; D049896:Crassostrea / Q000145:classification / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D006434:Hemocytes / Q000276:immunology; D037102:Lectins / Q000235:genetics* / Q000378:metabolism; D010802:Phylogeny; D017422:Sequence Analysis, DNA
chemical_list: D037102:Lectins
keywords: Hemocytes; Immune receptor molecules; Innate immunity; Mollusca