title: [Dynamic maternal measles antibody level in infants: a longitudinal study].
abstract: OBJECTIVE
  To understand the dynamic maternal measles antibody level in infants in Guangzhou.
  
  
  METHODS
  Women who delivered babies in a maternal and child health care hospital in Guangzhou and their infants who were never affected by measles were included in our study. All the serum samples collected from mothers and infants were tested by using enzyme linked immunosorbent assay(ELISA)for the quantitative measurement of measles IgG antibodies. A longitudinal sero-epidemiological study was conducted to investigate the duration of the presence of measles maternal antibodies in infants based on the measurement at different time points(0, 3, 5, 7 month).
  
  
  RESULTS
  A total of 689 mothers and their 691 infants(two pairs of twins)were included in the study. The concentration and the sero-positivity rate of measles antibody in mothers was 513.8 mIU/ml and 81.6% respectively. The concentration and the sero-positivity rate of measles antibody in infants was 732.8 mIU/ml and 87.3%, respectively. The measles antibody levels of newborns were positively associated with those of mothers(r=0.917 5, P<0.001), which declined rapidly at 3 months after birth and mostly turned to be negative at 7 months after birth. Measles antibody turned be negative at 3 months after birth in low, middle level groups, but remained to be positive in high level group at 5 months after birth.
  
  
  CONCLUSIONS
  The maternal measles antibody could rarely protect infants at age of 8 months even though mother had been vaccinated or acquired natural immunity. It is suggested to adjust the time of the first dose measles vaccination in infants and increase the measles antibody level of child bearing aged women to reduce the incidence of measles in infants.
authors.affiliation: Director Office, Liwan District Center for Disease Control and Prevention, Guangzhou 510176, China.
authors.forename: L
authors.initials: L
authors.lastname: Lu
authors.affiliation: Virology and Immunology Laboratory, Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Cao
authors.affiliation: Department of AIDS/STD Control and Prevention, Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.
authors.forename: Q Y
authors.initials: QY
authors.lastname: Yang
authors.affiliation: Department of Immunization Program, Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.
authors.forename: Q
authors.initials: Q
authors.lastname: He
authors.affiliation: Executive Office for Managing Action in Disease Control and Prevention, Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Dong
authors.affiliation: Virology and Immunology Laboratory, Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.
authors.forename: B
authors.initials: B
authors.lastname: Di
authors.affiliation: Department of Primary Public Health, Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.
authors.forename: C X
authors.initials: CX
authors.lastname: Fu
authors.affiliation: Director Office, Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.
authors.forename: M
authors.initials: M
authors.lastname: Wang
mesh_terms: D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology*; D002648:Child; D002681:China; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006761:Hospitals; D006801:Humans; D007112:Immunity, Maternally-Acquired / Q000276:immunology; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008431:Maternal-Fetal Exchange; D008457:Measles / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control*; D009035:Mothers / Q000706:statistics & numerical data; D011247:Pregnancy; D012698:Serologic Tests; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral