title: Soluble Toll-like receptor 4 is a potential serum biomarker in non-small cell lung cancer.
abstract: This study investigated the clinical significance of serum soluble Toll-like receptor 4 (sTLR4) in non-small cell lung cancer (NSCLC). A total of 54 NSCLC patients and 13 healthy volunteers were enrolled from January 2012 to December 2013. The patients with NSCLC were characterized by significantly higher serum levels of sTLR4 compared with those in healthy controls (P < 0.01). A positive correlation between serum sTLR4 and tumor stage was found in patients with stages I-III NSCLC. However, serum sTLR4 in patients with metastatic NSCLC was significantly decreased compared with those with stage III NSCLC (P < 0.05). Furthermore, low serum sTLR4 was identified as a prognostic marker for poor survival of early-stage NSCLC patients who received surgical resection. In conclusion, our present study identified sTLR4 as a potential serum biomarker of NSCLC.
authors.affiliation: Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, PR China.|National Clinical Research Center for Cancer, Tianjin, PR China.|Tianjin Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wei
authors.affiliation: Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, PR China.|National Clinical Research Center for Cancer, Tianjin, PR China.|Tianjin Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, PR China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, PR China.|National Clinical Research Center for Cancer, Tianjin, PR China.|Tianjin Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, PR China.|National Clinical Research Center for Cancer, Tianjin, PR China.|Tianjin Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, PR China.|National Clinical Research Center for Cancer, Tianjin, PR China.|Tianjin Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, PR China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Yu
authors.affiliation: Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, PR China.|National Clinical Research Center for Cancer, Tianjin, PR China.|Tianjin Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, PR China.
authors.forename: Lili
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, PR China.|Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, PR China.|National Clinical Research Center for Cancer, Tianjin, PR China.|Tianjin Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, PR China.
authors.forename: Xiubao
authors.initials: X
authors.lastname: Ren
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood*; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D024243:HMGB1 Protein / Q000097:blood; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D051197:Toll-Like Receptor 4 / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D024243:HMGB1 Protein; C585491:HMGB1 protein, human; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4
keywords: biomarker; high-mobility group box 1 (HMGB1); non-small cell lung cancer (NSCLC); soluble Toll-like receptor 4 (sTLR4)