title: Paneth Cell in Adenomas of the Distal Colorectum Is Inversely Associated with Synchronous Advanced Adenoma and Carcinoma.
abstract: Recent studies have linked appearance of Paneth cells in colorectal adenomas to adenoma burden and male gender. However, the clinical importance of Paneth cells' associations with synchronous advanced adenoma (AA) and colorectal carcinoma (CRC) is currently unclear. We performed a comprehensive case-control study using 1,900 colorectal adenomas including 785 from females, and 1,115 from males. We prospectively reviewed and recorded Paneth cell status in the colorectal adenomas consecutively collected between February 2014 and June 2015. Multivariable logistic regression analyses revealed that, in contrast to the adenomas without Paneth cells, the Paneth cell-containing adenomas at distal colorectum were inversely associated with presence of a synchronous AA or CRC (odds ratio [OR] 0.39, P = 0.046), whereas no statistical significance was reached for Paneth cell-containing proximal colorectal adenomas (P = 0.33). Synchronous AA and CRC were significantly associated with older age (60 + versus <60 years, OR 1.60, P = 0.002), male gender (OR 1.42, P = 0.021), and a history of AA or CRC (OR 2.31, P < 0.001). However, synchronous CRC was not associated with Paneth cell status, or a history of AA or CRC. Paneth cell presence in the adenomas of distal colorectum may be a negative indicator for synchronous AA and CRC, and seems to warrant further studies.
authors.affiliation: Department of Pathology, University Medical Center of Princeton, Plainsboro, New Jersey, USA.|Department of Pathology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
authors.forename: Megan
authors.initials: M
authors.lastname: Mahon
authors.affiliation: Department of Infectious Diseases, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Xianghua
authors.initials: X
authors.lastname: Yi
authors.affiliation: Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Biological Sciences, Rutgers University, Newark, NJ, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Gao
authors.affiliation: Department of Pathology, University Medical Center of Princeton, Plainsboro, New Jersey, USA.|Department of Pathology, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.|Department of Chemical Biology, Ernest Mario School of Pharmacy, Piscataway, New Jersey, USA.|Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey, USA.
authors.forename: Lanjing
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000453:epidemiology* / Q000473:pathology*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000473:pathology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019879:Paneth Cells / Q000502:physiology*; D011446:Prospective Studies