title: Impact of T cell activation, HIV replication and hepatitis C virus infection on neutrophil CD64 expression.
abstract: Overexpression of the Fc receptor CD64 on neutrophils is associated with innate immune response and bacterial infections. During HIV infection a large set of immune disorders including T-lymphocyte over-activation, microbial translocation, impairment of neutrophil functions, and immunodeficiency may interplay with neutrophil CD64 expression.
  
  
  
  Associations of neutrophil CD64 expression with CD8+T cell activation, CD4+T cells number, HIV, and HCV replications were investigated in HIV infected patients using a standardized method.
  
  
  
  Higher neutrophil CD64 expression was observed in HIV infected subjects compared to healthy controls (0.91 vs. 0.75, P < 0.001). Among 115 HIV infected patients, nine (8.8%) had a CD64 expression over the clinical threshold as calculated against bead standard (i.e., 1.5). HIV viremic patients were more likely to have an index above 1.5 (OR: 6.68, P values: 0.01). A trend for correlation between CD64 expression and CD8 T cell activation was observed (P values: 0.08). Blood CD4+T lymphocyte depletion and HCV replication did not affect neutrophil CD64 expression.
  
  
  
  HIV infection and HIV replication are associated with up-regulation of neutrophil CD64. CD64 overexpression above the clinical threshold was observed in a minor proportion of HIV infected individuals treated by antiretroviral therapy and may be a marker of neutrophil activation related to non-AIDS-linked comorbidities. © 2016 International Clinical Cytometry Society.
authors.affiliation: Infectious and Tropical Diseases Department, UMI 233, Gui De Chauliac, University Hospital of Montpellier, Montpellier, France.
authors.forename: D
authors.initials: D
authors.lastname: Morquin
authors.affiliation: Infectious and Tropical Diseases Department, UMI 233, Gui De Chauliac, University Hospital of Montpellier, Montpellier, France.|Department of Microbiology, Université Montpellier 1/Inserm UMR 1058, Lapeyronie, University Hospital of Montpellier, Montpellier, France.
authors.forename: E
authors.initials: E
authors.lastname: Tuaillon
authors.affiliation: Infectious and Tropical Diseases Department, UMI 233, Gui De Chauliac, University Hospital of Montpellier, Montpellier, France.
authors.forename: A
authors.initials: A
authors.lastname: Makinson
authors.affiliation: Department of Microbiology, Université Montpellier 1/Inserm UMR 1058, Lapeyronie, University Hospital of Montpellier, Montpellier, France.
authors.forename: S
authors.initials: S
authors.lastname: Bendriss
authors.affiliation: Infectious and Tropical Diseases Department, UMI 233, Gui De Chauliac, University Hospital of Montpellier, Montpellier, France.
authors.forename: V
authors.initials: V
authors.lastname: Le Moing
authors.affiliation: Infectious and Tropical Diseases Department, UMI 233, Gui De Chauliac, University Hospital of Montpellier, Montpellier, France.
authors.forename: J
authors.initials: J
authors.lastname: Reynes
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000821:virology; D060085:Coinfection; D005260:Female; D005786:Gene Expression Regulation; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000276:immunology; D016174:Hepacivirus / Q000187:drug effects / Q000276:immunology; D006526:Hepatitis C / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000821:virology; D006801:Humans; D008213:Lymphocyte Activation; D008212:Lymphocyte Depletion; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology* / Q000821:virology; D011446:Prospective Studies; D012367:RNA, Viral / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics; D017452:Receptors, IgG / Q000235:genetics* / Q000276:immunology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral; D017452:Receptors, IgG
keywords: hepatitis C virus; human immunodeficiency virus; inflammation; neutrophil CD64