title: A reversible B-A transition of DNA duplexes induced by synthetic cationic copolymers.
abstract: Although the B-form duplex is the canonical DNA structure, the A-form duplex plays critical roles in controlling gene expression. Here, reversible B-A transitions of DNA duplexes were induced by synthetic cationic and anionic polymers. Thermodynamic analysis demonstrated that the B-A transition was regulated by the dehydration of the DNA duplex caused by polymer binding.
authors.affiliation: Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.
authors.forename: Nonoka
authors.initials: N
authors.lastname: Yamaguchi
authors.forename: Yu-Ki
authors.initials: YK
authors.lastname: Zouzumi
authors.forename: Naohiko
authors.initials: N
authors.lastname: Shimada
authors.forename: Shu-Ichi
authors.initials: S
authors.lastname: Nakano
authors.forename: Naoki
authors.initials: N
authors.lastname: Sugimoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Maruyama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Miyoshi
mesh_terms: D002412:Cations / Q000138:chemical synthesis / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D002412:Cations; D011108:Polymers; D004247:DNA