title: von Willebrand factor antigen as a therapeutic target of portal hypertension in cirrhosis.
abstract: Increased thrombotic potential within the liver sinusoids due to local endothelial production of von Willebrand factor antigen macromolecules could represent an additional therapeutic target of portal hypertension in patients with cirrhosis. In this case, anti-inflammatory and antithrombotic drugs could modulate portal pressure by preventing the formation of intrahepatic platelet-induced microthrombi.
authors.affiliation: Georgios N Kalambokis, 1 Division of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece.
authors.forename: Georgios N
authors.initials: GN
authors.lastname: Kalambokis
authors.affiliation: Georgios N Kalambokis, 1 Division of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece.
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Baltayiannis
authors.affiliation: Georgios N Kalambokis, 1 Division of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Christodoulou
mesh_terms: D001792:Blood Platelets; D006503:Hepatic Veins; D006801:Humans; D006975:Hypertension, Portal; D008103:Liver Cirrhosis; D014841:von Willebrand Factor
chemical_list: D014841:von Willebrand Factor
keywords: Endothelial dysfunction; Portal hypertension; Treatment; von Willebrand factor antigen