title: Intracellular Redox Compartmentation and ROS-Related Communication in Regulation and Signaling.
abstract: Recent years have witnessed enormous progress in understanding redox signaling related to reactive oxygen species (ROS) in plants. The consensus view is that such signaling is intrinsic to many developmental processes and responses to the environment. ROS-related redox signaling is tightly wedded to compartmentation. Because membranes function as barriers, highly redox-active powerhouses such as chloroplasts, peroxisomes, and mitochondria may elicit specific signaling responses. However, transporter functions allow membranes also to act as bridges between compartments, and so regulated capacity to transmit redox changes across membranes influences the outcome of triggers produced at different locations. As well as ROS and other oxidizing species, antioxidants are key players that determine the extent of ROS accumulation at different sites and that may themselves act as signal transmitters. Like ROS, antioxidants can be transported across membranes. In addition, the intracellular distribution of antioxidative enzymes may be modulated to regulate or facilitate redox signaling appropriate to the conditions. Finally, there is substantial plasticity in organellar shape, with extensions such as stromules, peroxules, and matrixules playing potentially crucial roles in organelle-organelle communication. We provide an overview of the advances in subcellular compartmentation, identifying the gaps in our knowledge and discussing future developments in the area.
authors.affiliation: Institute of Plant Sciences Paris Saclay, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université Paris-Sud, Université Evry, Paris Diderot, Sorbonne Paris-Cité, Université Paris-Saclay, 91405 Orsay, France (G.N.); andCentre for Plant Sciences, School of Biology and Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom (C.H.F.) graham.noctor@u-psud.fr cfoyer@leeds.ac.uk.
authors.forename: Graham
authors.identifier: 0000-0003-1980-4554
authors.initials: G
authors.lastname: Noctor
authors.affiliation: Institute of Plant Sciences Paris Saclay, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université Paris-Sud, Université Evry, Paris Diderot, Sorbonne Paris-Cité, Université Paris-Saclay, 91405 Orsay, France (G.N.); andCentre for Plant Sciences, School of Biology and Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom (C.H.F.) graham.noctor@u-psud.fr cfoyer@leeds.ac.uk.
authors.forename: Christine H
authors.identifier: 0000-0001-5989-6989
authors.initials: CH
authors.lastname: Foyer
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D001692:Biological Transport; D002451:Cell Compartmentation; D002467:Cell Nucleus / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism; D010084:Oxidation-Reduction; D059828:Plant Cells / Q000378:metabolism*; D010944:Plants / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide