title: Neuroprotective effects of adalimumab on rats with experimental peripheral nerve injury: An electron microscopic and biochemical study.
abstract: BACKGROUND
  Adalimumab, a new-generation anti-inflammatory agent, exerts its effect through tumor necrosis factor α (TNF-α), secreted from immune response cells such as macrophages and lymphocytes. TNF-α has been shown to play an important role in the processes of apoptosis and demyelination, and blockage of its activity may improve neural healing. Investigated in the present study is the probable neuroprotective influence of adalimumab in rats using a peripheral nerve injury model with biochemical and electron microscopic methods.
  
  
  METHODS
  Forty adult Wistar albino rats were randomly divided into control, sciatic nerve trauma, low-dose adalimumab, and high-dose adalimumab groups. Six rats from each group were assigned biochemical microscopy, and 4 were assigned electron microscopy. Neural injury was induced with clip compression following dissection of sciatic nerves. Adalimumab was simultaneously injected. The rats were sacrificed after 2 weeks of adalimumab treatment.
  
  
  RESULTS
  Nerve tissue lipid peroxidation values were found to be significantly decreased in both the low- and high-dose adalimumab treatment groups, compared to the group subjected only to sciatic nerve trauma.
  
  
  CONCLUSIONS
  Results demonstrate that adalimumab is an effective neuroprotective agent for neural healing, particularly in the early phase.
authors.affiliation: Department of Neurosurgery, Bafra State Hospital, Samsun-Turkey.
authors.forename: Ersin
authors.initials: E
authors.lastname: Polat
authors.affiliation: Department of Neurosurgery, Ankara Numune Training and Research Hospital, Ankara-Turkey.
authors.forename: Ergün
authors.initials: E
authors.lastname: Dağlıoğlu
authors.affiliation: Department of Neurosurgery, Ankara Training and Research Hospital, Ankara-Turkey.
authors.forename: Güner
authors.initials: G
authors.lastname: Menekşe
authors.affiliation: Department of Neurosurgery, Ceyhan State Hospital, Adana-Turkey.
authors.forename: Mehmet Serdar
authors.initials: MS
authors.lastname: Dike
authors.affiliation: Department of Neurosurgery, Antalya Training and Research Hospital, Antalya-Turkey.
authors.forename: Çağatay
authors.initials: Ç
authors.lastname: Özdöl
authors.affiliation: Department of Neurosurgery, Antalya Training and Research Hospital, Antalya-Turkey.
authors.forename: Cezmi Çağrı
authors.initials: CÇ
authors.lastname: Türk
authors.affiliation: Department of Neurosurgery, Ankara Numune Training and Research Hospital, Ankara-Turkey.
authors.forename: Ali Erdem
authors.initials: AE
authors.lastname: Yıldırım
authors.affiliation: Department of Neurosurgery, Ankara Numune Training and Research Hospital, Ankara-Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Alagöz
authors.affiliation: Department of Neurosurgery, Ankara Numune Training and Research Hospital, Ankara-Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Dalgıç
authors.affiliation: Department of Neurosurgery, Ankara Numune Training and Research Hospital, Ankara-Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Belen
mesh_terms: D000068879:Adalimumab / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008854:Microscopy, Electron; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D059348:Peripheral Nerve Injuries / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000293:injuries* / Q000648:ultrastructure
chemical_list: D018696:Neuroprotective Agents; D000068879:Adalimumab