title: Drug-Resistant Tuberculosis: Challenges and Progress.
abstract: Antimicrobial resistance is a natural evolutionary process, which in the case of Mycobacterium tuberculosis is based on spontaneous chromosomal mutations, meaning that well-designed combination drug regimens provided under supervised therapy will prevent the emergence of drug-resistant strains. Unfortunately, limited resources, poverty, and neglect have led to the emergence of drug-resistant tuberculosis throughout the world. The international community has responded with financial and scientific support, leading to new rapid diagnostics, new drugs and regimens in advanced clinical development, and an increasingly sophisticated understanding of resistance mechanisms and their application to all aspects of TB control and treatment.
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Tufts University School of Medicine, 800 Washington Street, #257, Boston, MA 02111, USA. Electronic address: SKurz1@tuftsmedicalcenter.org.
authors.forename: Sebastian G
authors.initials: SG
authors.lastname: Kurz
authors.affiliation: Department of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Furin
authors.affiliation: Division of Infectious Diseases, Department of Medicine, MetroHealth Medical Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
authors.forename: Charles M
authors.initials: CM
authors.lastname: Bark
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000472:pathogenicity; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents
keywords: Antimicrobial resistance; Drug-resistant tuberculosis; Mycobacterium tuberculosis