title: New Directions in Medication-Facilitated Behavioral Treatment for Substance Use Disorders.
abstract: A promising approach to addressing substance use disorders is to integrate pharmacotherapy with a behavioral treatment with which synergy is possible. In this review, we focus on recent research suggesting that this approach may be effective for cocaine and cannabis use disorders, both of which currently lack efficacious medications. We summarize potential targets of pharmacotherapy of particular relevance to combined medication-behavioral treatment and examine preliminary evidence of clinical efficacy. Common to these promising medications is a hypothesized mechanism of action predicated on reversing drug-related neural adaptations, such as high reactivity to stress or drug cues, that might undermine fruitful engagement with behavioral treatment. We also review emerging medications, such as certain glutamatergic and serotonergic agents, which may be feasibly integrated with existing treatments. We conclude with an outline of future directions for research.
authors.affiliation: Division on Substance Abuse, Department of Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons at Columbia University Medical Center, New York, NY, USA. dakware@nyspi.columbia.edu.
authors.forename: Elias
authors.initials: E
authors.lastname: Dakwar
authors.affiliation: Division on Substance Abuse, Department of Psychiatry, New York State Psychiatric Institute, College of Physicians and Surgeons at Columbia University Medical Center, New York, NY, USA.
authors.forename: Edward V
authors.initials: EV
authors.lastname: Nunes
mesh_terms: D001521:Behavior Therapy / Q000379:methods*; D003131:Combined Modality Therapy; D006801:Humans; D011619:Psychotropic Drugs / Q000494:pharmacology*; D019966:Substance-Related Disorders / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D011619:Psychotropic Drugs
keywords: Addiction; Behavioral treatment; Cannabis; Cocaine; Combined treatment; Medication; Use disorder