title: Association between in vitro fertilization outcomes and inherited thrombophilias: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to determine whether in vitro fertilization (IVF) outcomes are associated with inherited thrombophilias.
  
  
  METHODS
  Several databases including PubMed, Embase, and Cochrane Library were retrieved up to 12 January 2016. The quality of the included studies was assessed by two authors. The associations of the following mutations in inherited thrombophilias and IVF outcomes were explored: factor V Leiden (FVL), prothrombin gene G20210A mutation (PGM), 5,10-methylentetrahydrofolate reductase (MTHFR) C677T, MTHFR (A1298C) and activated protein C resistance (APCR). The main outcome measures included CPR and implantation rate (IR). The relative risk (RR) and its 95 % confidence interval (CI) were calculated for effect index. Heterogeneity test was evaluated by Chi-square based on Q statistic and I (2) statistics.
  
  
  RESULTS
  A total of seven articles published between 2007 and 2015 with the ages of subjects between 30.9 and 36.2 were included. For subgroups analysis of CPR or IR, there were no significant differences in MTHFR (C377T), MTHFR (A1298C), FVL, PGM, and FVL/PGM mutation were found between the mutation group and control group (P > 0. 05).
  
  
  CONCLUSIONS
  IVF outcomes are not associated with FVL, PGM, MTHFR (C677T), MTHFR (A1298C), and APCR mutation in inherited thrombophilias.
authors.affiliation: Maternal and child health care hospital of Nantong City, No. 399 Century Avenue, Nantong, 226006, China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Tan
authors.affiliation: First Maternity and Infant Hospital of Shanghai City, Pudong, China.
authors.forename: Zhenbo
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Maternal and child health care hospital of Nantong City, No. 399 Century Avenue, Nantong, 226006, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Sao
authors.affiliation: Maternal and child health care hospital of Nantong City, No. 399 Century Avenue, Nantong, 226006, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Maternal and child health care hospital of Nantong City, No. 399 Century Avenue, Nantong, 226006, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Maternal and child health care hospital of Nantong City, No. 399 Century Avenue, Nantong, 226006, China.
authors.forename: Jiayi
authors.initials: J
authors.lastname: Ding
authors.affiliation: Maternal and child health care hospital of Nantong City, No. 399 Century Avenue, Nantong, 226006, China. weihongshiws@aliyun.com.
authors.forename: Weihong
authors.initials: W
authors.lastname: Shi
mesh_terms: D020016:Activated Protein C Resistance / Q000235:genetics; D000328:Adult; D010064:Embryo Implantation / Q000235:genetics*; D005165:Factor V / Q000235:genetics; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D019851:Thrombophilia / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: In vitro fertilization; Inherited thrombophilias; Meta-analysis