title: Discovery of a highly potent FLT3 kinase inhibitor for FLT3-ITD-positive AML.
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|University of Science and Technology of China, Hefei, China.
authors.forename: H
authors.initials: H
authors.lastname: Wu
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|University of Science and Technology of China, Hefei, China.
authors.forename: A
authors.initials: A
authors.lastname: Wang
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Qi
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei, China.
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei, China.
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|University of Science and Technology of China, Hefei, China.
authors.forename: K
authors.initials: K
authors.lastname: Yu
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei, China.
authors.forename: F
authors.initials: F
authors.lastname: Zou
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|University of Science and Technology of China, Hefei, China.
authors.forename: C
authors.initials: C
authors.lastname: Hu
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei, China.
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|University of Science and Technology of China, Hefei, China.
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|University of Science and Technology of China, Hefei, China.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|University of Science and Technology of China, Hefei, China.
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei, China.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei, China.
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.affiliation: CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei, China.|Hefei Cosource Medicine Technology Co. LTD., Hefei, China.
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Stone
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: I A
authors.initials: IA
authors.lastname: Galinsky
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Griffin
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Weinstock
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Christodoulou
authors.affiliation: Department of Hematology, The Second Hospital of Anhui Medical University, Hefei, China.|Hematology Research Center, Anhui Medical University, Hefei, China.
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Hematology, The Second Hospital of Anhui Medical University, Hefei, China.|Hematology Research Center, Anhui Medical University, Hefei, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Hematology, The Second Hospital of Anhui Medical University, Hefei, China.|Hematology Research Center, Anhui Medical University, Hefei, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhai
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: E L
authors.initials: EL
authors.lastname: Weisberg
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei, China.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.affiliation: High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China.|University of Science and Technology of China, Hefei, China.|CHMFL-HCMTC Target Therapy Joint Laboratory, Hefei, China.|Hefei Science Center, Chinese Academy of Sciences, Hefei, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D055808:Drug Discovery; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D047428:Protein Kinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D047428:Protein Kinase Inhibitors