title: Once-daily prolonged-release tacrolimus formulations for kidney transplantation: what the nephrologist needs to know.
abstract: Tacrolimus has long been the cornerstone of the immunosuppressive standard-of-care in kidney transplantation. Until recently, only an immediate-release formulation of tacrolimus was available in the clinic for twice-daily administration, a schedule that is known to hamper prescription adherence and contributes to the already significant tacrolimus interactions with other drugs and meals. In order to improve patient compliance, two once-daily prolonged-release formulations of tacrolimus have recently been developed and approved. Here we will analyze the main characteristics of these two prolonged-release formulations with the aim to provide practical clinical information for a fully aware drug prescription. Finally, the theoretical advantages of the prolonged-release formulations in terms of prescription adherence, blood level steadiness and drug efficacy and tolerability will be critically reviewed, in order to define the profile of renal recipients who may benefit most from the switch to once-daily tacrolimus.
authors.affiliation: Kidney and Pancreas Transplantation Unit, University Hospital of Parma, Parma, Italy. gpiotti@yahoo.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Piotti
authors.affiliation: Kidney and Pancreas Transplantation Unit, University Hospital of Parma, Parma, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Cremaschi
authors.affiliation: Kidney and Pancreas Transplantation Unit, University Hospital of Parma, Parma, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Maggiore
mesh_terms: D051544:Cytochrome P-450 CYP3A / Q000235:genetics; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D016030:Kidney Transplantation; D055118:Medication Adherence; D000072104:Nephrologists; D016559:Tacrolimus / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood
chemical_list: D003692:Delayed-Action Preparations; D007166:Immunosuppressive Agents; D051544:Cytochrome P-450 CYP3A; D016559:Tacrolimus
keywords: Extended-release; Immunosuppression; Kidney transplantation; Once-daily; Prolonged-release; Tacrolimus