title: Synthesis and characterization of smart N-isopropylacrylamide-based magnetic nanocomposites containing doxorubicin anti-cancer drug.
abstract: In the present study, magnetic and thermo/pH-sensitive (multiresponsive) nanocomposites based on N-isopropylacrylamide (NIPAAM) were synthesized and characterized. Nanocomposites were synthesized by free radical emulsion polymerization of NIPAAM as thermosensitive monomer and N,N-dimethyl-aminoethyl methacrylate (DMAEMA) as pH-sensitive monomer in the presence of methylene-bis-acrylamide as cross-linking agent. Doxorubicin, an anti-cancer drug, was loaded into these nanocomposites via equilibrium swelling method. Thermo/pH-sensitive cross-linked poly (NIPAAM-DMAEMA)-Fe3O4nanocomposites were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and vibrating sample magnetometer (VSM). The volume of the loaded drug and drug release amount was determined by UV measurements. The results showed that this thermo/pH-sensitive magnetic nanocomposite has a high drug-loading efficiency. Doxorubicin was released at 40 °C and pH 5.8 more than the 37 °C and pH 7.4.
authors.affiliation: a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz, Iran.|b Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Medical University of Tabriz , Tabriz, Iran.
authors.forename: Soheila
authors.initials: S
authors.lastname: Motaali
authors.affiliation: a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Pashaeiasl
authors.affiliation: a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz, Iran.|b Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Medical University of Tabriz , Tabriz, Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
authors.affiliation: a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz, Iran.|b Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Medical University of Tabriz , Tabriz, Iran.
authors.forename: Soodabeh
authors.initials: S
authors.lastname: Davaran
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers; D004339:Drug Compounding; D065546:Drug Liberation; D052203:Ferrosoferric Oxide / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D059346:Magnets; D008689:Methacrylates / Q000737:chemistry; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D058105:Polymerization; D013696:Temperature
chemical_list: D000178:Acrylamides; D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D008689:Methacrylates; D004317:Doxorubicin; C067295:N-isopropylacrylamide; C021221:N,N'-methylenebisacrylamide; C049840:2-(dimethylamino)ethyl methacrylate; D052203:Ferrosoferric Oxide
keywords: Doxorubicin; NIPAAM; multiresponsive; nanocomposites