title: Functionalized Benzimidazole Scaffolds: Privileged Heterocycle for Drug Design in Therapeutic Medicine.
abstract: Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of biologically active compounds which are therapeutically useful agents in drug discovery and medicinal research. They are structural isosteres of naturally occurring nucleotides, which allows them to interact with the biopolymers of living systems. Hence, there is a need to couple the latest information with the earlier documentations to understand the current status of the benzimidazole nucleus in medicinal chemistry research. This present work unveils the benzimidazole core as a multifunctional nucleus that serves as a resourceful tool of information for synthetic modifications of old existing candidates in order to tackle drug resistance bottlenecks in therapeutic medicine. This manuscript deals with the recent advances in the synthesis of benzimidazole derivatives, the widespread biological activities as well as pharmacokinetic reports. These present them as a toolbox for fighting infectious diseases and also make them excellent candidates for future drug design.
authors.affiliation: Department of Chemistry, Covenant University, CST, Canaanland, Ota, Ogun State, Nigeria.
authors.forename: Olayinka O
authors.initials: OO
authors.lastname: Ajani
authors.affiliation: Department of Chemistry, Covenant University, CST, Canaanland, Ota, Ogun State, Nigeria.
authors.forename: Damilola V
authors.initials: DV
authors.lastname: Aderohunmu
authors.affiliation: Department of Chemistry, University of the Western Cape, Bellville, Cape Town, South Africa.
authors.forename: Chinwe O
authors.initials: CO
authors.lastname: Ikpo
authors.affiliation: Department of Chemistry, Covenant University, CST, Canaanland, Ota, Ogun State, Nigeria.
authors.forename: Adebusayo E
authors.initials: AE
authors.lastname: Adedapo
authors.affiliation: Department of Chemistry, Covenant University, CST, Canaanland, Ota, Ogun State, Nigeria.
authors.forename: Ifedolapo O
authors.initials: IO
authors.lastname: Olanrewaju
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D004351:Drug Resistance / Q000187:drug effects; D006801:Humans; D062105:Molecular Docking Simulation; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D001562:Benzimidazoles
keywords: Antibacterial activity; Cycloaddition; Cytotoxic activity; HIV-1; Rational drug design