title: Dietary selenium intake and mortality in two population-based cohort studies of 133 957 Chinese men and women.
abstract: To investigate the potential influence of dietary Se intake on mortality among Chinese populations.
  
  
  
  We prospectively evaluated all-cause, CVD and cancer mortality risks associated with dietary Se intake in participants of the Shanghai Women's Health Study (SWHS) and the Shanghai Men's Health study (SMHS). Dietary Se intake was assessed by validated FFQ during in-person interviews. Cox proportional hazards models were used to calculate hazard ratios (HR) and 95 % CI.
  
  
  
  Urban city in China.
  
  
  
  Chinese adults (n 133 957).
  
  
  
  During an average follow-up of 13·90 years in the SWHS and 8·37 years in the SMHS, 5749 women and 4217 men died. The mean estimated dietary Se intake was 45·48 μg/d for women and 51·34 μg/d for men, respectively. Dietary Se intake was inversely associated with all-cause mortality and CVD mortality in both women and men, with respective HR for the highest compared with the lowest quintile being 0·79 (95 % CI 0·71, 0·88; P trend<0·0001) and 0·80 (95 % CI 0·66, 0·98; P trend=0·0268) for women, and 0·79 (95 % CI 0·70, 0·89; P trend=0·0001) and 0·66 (95 % CI 0·54, 0·82; P trend=0·0002) for men. No significant associations were observed for cancer mortality in both women and men. Results were similar in subgroup and sensitivity analyses.
  
  
  
  Dietary Se intake was inversely associated with all-cause and cardiovascular mortality in both sexes, but not cancer mortality.
authors.affiliation: 1School of Public Health,Fudan University,Shanghai,People's Republic of China.
authors.forename: Jiang-Wei
authors.initials: JW
authors.lastname: Sun
authors.affiliation: 3Division of Epidemiology,Department of Medicine,Vanderbilt Epidemiology Center,Vanderbilt-Ingram Cancer Center,Vanderbilt University School of Medicine,Nashville,TN,USA.
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.affiliation: 2Shanghai Cancer Institute,Renji Hospital,Shanghai Jiaotong University School of Medicine,No. 25 Lane 2200,Xie Tu Road,Shanghai 200032,People's Republic of China.
authors.forename: Hong-Lan
authors.initials: HL
authors.lastname: Li
authors.affiliation: 2Shanghai Cancer Institute,Renji Hospital,Shanghai Jiaotong University School of Medicine,No. 25 Lane 2200,Xie Tu Road,Shanghai 200032,People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: 2Shanghai Cancer Institute,Renji Hospital,Shanghai Jiaotong University School of Medicine,No. 25 Lane 2200,Xie Tu Road,Shanghai 200032,People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.affiliation: 2Shanghai Cancer Institute,Renji Hospital,Shanghai Jiaotong University School of Medicine,No. 25 Lane 2200,Xie Tu Road,Shanghai 200032,People's Republic of China.
authors.forename: Long-Gang
authors.initials: LG
authors.lastname: Zhao
authors.affiliation: 3Division of Epidemiology,Department of Medicine,Vanderbilt Epidemiology Center,Vanderbilt-Ingram Cancer Center,Vanderbilt University School of Medicine,Nashville,TN,USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: 2Shanghai Cancer Institute,Renji Hospital,Shanghai Jiaotong University School of Medicine,No. 25 Lane 2200,Xie Tu Road,Shanghai 200032,People's Republic of China.
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiang
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000401:mortality; D002681:China; D004032:Diet; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009026:Mortality; D009369:Neoplasms / Q000401:mortality; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D012643:Selenium / Q000008:administration & dosage*
chemical_list: D012643:Selenium
keywords: China; Dietary; Mortality; Prospective study; Selenium intake