title: Commentary on Folkman: "How Is Blood Vessel Growth Regulated in Normal and Neoplastic Tissue?".
abstract: Angiogenesis is a prerequisite for tumor growth and metastatic progression. The discovery of the first specific angiogenic cytokine, VEGF, in 1989 paved the way for the clinical approval of the first antiangiogenic tumor drug 15 years later. This brief commentary highlights and puts into historical perspective the 1985 G.H.A. Clowes Memorial Award Lecture delivered by Dr. Judah Folkman. Thirty years later, this award lecture is a lively testimony of the visionary mind of Dr. Folkman, whose legacy continues to inspire contemporary angiogenesis research. Cancer Res; 76(10); 2854-6. ©2016 AACRSee related article by Folkman J, Cancer Res 1986;46:467-73.
authors.affiliation: Division of Vascular Oncology and Metastasis (DKFZ-ZMBH Alliance), German Cancer Research Center, Heidelberg, Germany. Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany. German Cancer Consortium, Heidelberg, Germany. augustin@angiogenese.de.
authors.forename: Hellmut G
authors.initials: HG
authors.lastname: Augustin
mesh_terms: D020533:Angiogenesis Inhibitors; D006801:Humans; D009369:Neoplasms; D009389:Neovascularization, Pathologic
chemical_list: D020533:Angiogenesis Inhibitors