title: Refinement of screening for familial pancreatic cancer.
abstract: Surveillance programmes are recommended for individuals at risk (IAR) of familial pancreatic cancer (FPC) to detect early pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC). However, the age to begin screening and the optimal screening protocol remain to be determined.
  
  
  
  IAR from non-CDKN2A FPC families underwent annual screening by MRI with endoscopic ultrasonography (EUS) in board-approved prospective screening programmes at three tertiary referral centres. The diagnostic yield according to age and different screening protocols was analysed.
  
  
  
  253 IAR with a median age of 48 (25-81) years underwent screening with a median of 3 (1-11) screening visits during a median follow-up of 28 (1-152) months. 134 (53%) IAR revealed pancreatic lesions on imaging, mostly cystic (94%), on baseline or follow-up screening. Lesions were significantly more often identified in IAR above the age of 45 years (p<0.0001). In 21 IAR who underwent surgery, no significant lesions (PDAC, pancreatic intraepithelial neoplasia (PanIN) 3 lesions, high-grade intraductal papillary mucinous neoplasia (IPMN)) were detected before the age of 50 years. Potentially relevant lesions (multifocal PanIN2 lesions, low/moderate-grade branch-duct IPMNs) occurred also significantly more often after the age of 50 years (13 vs 2, p<0.0004). The diagnostic yield of potentially relevant lesions was not different between screening protocols using annual MRI with EUS (n=98) or annual MRI with EUS every 3rd year (n=198) and between IAR screened at intervals of 12 months (n=180) or IAR that decided to be screened at ≥24 months intervals (n=30).
  
  
  
  It appears safe to start screening for PDAC in IAR of non-CDKN2a FPC families at the age of 50 years. MRI-based screening supplemented by EUS at baseline and every 3rd year or when changes in MRI occur appears to be efficient.
authors.affiliation: Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany.
authors.forename: D K
authors.initials: DK
authors.lastname: Bartsch
authors.affiliation: Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany.
authors.forename: E P
authors.initials: EP
authors.lastname: Slater
authors.affiliation: Department of Medical Oncology, Ramon y Cajal University Hospital, IRYCIS, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Carrato
authors.affiliation: Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: I S
authors.initials: IS
authors.lastname: Ibrahim
authors.affiliation: Department of Medical Oncology, Ramon y Cajal University Hospital, IRYCIS, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Guillen-Ponce
authors.affiliation: Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: H F A
authors.initials: HF
authors.lastname: Vasen
authors.affiliation: Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Matthäi
authors.affiliation: Department of Medical Oncology, Ramon y Cajal University Hospital, IRYCIS, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Earl
authors.affiliation: Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany.
authors.forename: F S
authors.initials: FS
authors.lastname: Jendryschek
authors.affiliation: Department of Radiology, Philipps University Marburg, Marburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Figiel
authors.affiliation: Department of Gastroenterology and Endocrinology, Philipps University Marburg, Marburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Steinkamp
authors.affiliation: Department of Pathology, Philipps University Marburg, Marburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Ramaswamy
authors.affiliation: Department of Gastroenterology, Ramon y Cajal University Hospital, IRYCIS, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Vázquez-Sequeiros
authors.affiliation: Department of Radiology, Ramon y Cajal University Hospital, IRYCIS, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Muñoz-Beltran
authors.affiliation: Department of Pathology, Ramon y Cajal University Hospital, IRYCIS, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Montans
authors.affiliation: Department of Medical Oncology, Ramon y Cajal University Hospital, IRYCIS, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Mocci
authors.affiliation: Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: B A
authors.initials: BA
authors.lastname: Bonsing
authors.affiliation: Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Wasser
authors.affiliation: Department of Pathology, Consultation Centre for Pancreatic Tumors, Technical University Munich, Munich, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Klöppel
authors.affiliation: Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany Department of General Surgery, Klinikum Hanau GmbH, Hanau, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Langer
authors.affiliation: Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Fendrich
authors.affiliation: Department of Gastroenterology and Endocrinology, Philipps University Marburg, Marburg, Germany.
authors.forename: T M
authors.initials: TM
authors.lastname: Gress
mesh_terms: D017668:Age of Onset; D002277:Carcinoma / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D055088:Early Detection of Cancer / Q000379:methods*; D019160:Endosonography / Q000379:methods; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010179:Pancreas / Q000000981:diagnostic imaging / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D013997:Time Factors
keywords: FAMILY CANCER; PANCREATIC CANCER; SCREENING