title: [A Case of Advanced Colon Cancer with Long-Term and Re-Administration of Regorafenib].
abstract: A 54-year-old woman diagnosed with sigmoid colon cancer and multiple liver metastases underwent sigmoidectomy, partial hepatectomy, and RFA in September 2009. Because of postoperative liver and lung recurrence, 5 regimens with combinations of L-OHP/CPT-11 plus anti-VEGF antibody/anti-EGFR antibody was performed. Following these treatments, she underwent hepatic arterial infusion therapy with UFT/Krestin for progressive liver metastases. Starting in November 2014, regorafenib was administered, with an immediate decrease in tumor marker levels; tumor reduction demonstrated enhanced effect against liver metastases. After 8 months of administration, we stopped regorafenib and changed to TAS-102 due to diarrhea and eating disorders. However, TAS-102 was not effective; there were significant increases in tumor markers, liver function tests, and tumor size on computed tomography, and worsening of abdominal pain. After re-administration of regorafenib, a rapid decrease in tumor marker levels and improvement of liver dysfunction and abdominal pain were observed. Re-administration continued for 8 months until best supportive care was instituted. In cases with observed therapeutic effect of regorafenib, long-term or re-administration is possible, with extension of the prognosis depending on the adjustment, and without size reduction of metastatic tumors.
authors.affiliation: Dept. of Surgery, Hokkaido P. W. F. A. C. Asahikawa-Kosei General Hospital.
authors.forename: Tohru
authors.initials: T
authors.lastname: Funakoshi
authors.forename: Takuya
authors.initials: T
authors.lastname: Kato
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kuratani
authors.forename: Kenji
authors.initials: K
authors.lastname: Yamada
authors.forename: Sachiko
authors.initials: S
authors.lastname: Kenno
authors.forename: Taiichiro
authors.initials: T
authors.lastname: Shibaki
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Yanagida
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Inagaki
authors.forename: Sunao
authors.initials: S
authors.lastname: Ikeue
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Akabane
authors.forename: Shiro
authors.initials: S
authors.lastname: Nakano
mesh_terms: D003082:Colectomy; D017809:Fatal Outcome; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008875:Middle Aged; D010671:Phenylurea Compounds / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D012811:Sigmoid Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013997:Time Factors
chemical_list: D010671:Phenylurea Compounds; D011725:Pyridines; C559147:regorafenib