title: Anti-neutrophil cytoplasmic antibody negative crescentic paucimmune glomerulonephritis in a case of scleroderma with systemic lupus erythematosus overlap.
abstract: Renal Involvement in scleroderma is a known problem and the manifestations are well described. Renal involvement in systemic lupus erythematosus (SLE) is also well known. However, in scleroderma and SLE overlap syndrome, the renal findings may vary being a combination of features of immune complex mediated glomerulonephritis as well as thrombotic microangiopathy. We report a case in which the renal manifestation in such a situation was of a focal necrotising pauci-immune glomerulonephritis with crescents, anti-neutrophil cytoplasmic antibody negative. To the best of our knowledge, such manifestations have not been described before. Renal dysfunction in a normotensive setting in such a case should direct one towards evaluation for other causes and should prompt a kidney biopsy. This would be valuable in delineating the pathological process in the kidney and would help in guiding therapy.
authors.affiliation: Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India.
authors.forename: Rohit
authors.initials: R
authors.lastname: Tewari
authors.affiliation: Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India.
authors.forename: Sonia
authors.initials: S
authors.lastname: Badwal
authors.affiliation: Department of Medicine, Armed Forces Medical College, Pune, Maharashtra, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Medicine, Armed Forces Medical College, Pune, Maharashtra, India.
authors.forename: Shankar
authors.initials: S
authors.lastname: Subramaniam
authors.affiliation: Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India.
authors.forename: V S
authors.initials: VS
authors.lastname: Nijhawan
authors.affiliation: Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India.
authors.forename: V
authors.initials: V
authors.lastname: Srinivas
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic; D005260:Female; D005921:Glomerulonephritis; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008180:Lupus Erythematosus, Systemic; D012595:Scleroderma, Systemic
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic