title: Homing in on the Sweet Side of Immune Checkpoint Biology.
abstract: P-selectin glycoprotein ligand-1 (PSGL-1) and its glycostructural determinants facilitate responses to infection and cancer by promoting immune effector-cell trafficking into inflamed tissue. In this issue of Immunity, Tinoco et al. (2016) report homing-independent functions of PSGL-1 in immune checkpoint regulation and T cell effector activity, in models of chronic viral infection and melanoma.
authors.affiliation: Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Barthel
authors.affiliation: Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: tschatton@bwh.harvard.edu.
authors.forename: Tobias
authors.initials: T
authors.lastname: Schatton
mesh_terms: D059447:Cell Cycle Checkpoints; D002465:Cell Movement / Q000276:immunology; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry*; D019007:P-Selectin / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D008562:Membrane Glycoproteins; D019007:P-Selectin; C084882:P-selectin ligand protein