title: Antithyroid drug induced a granulocytosis: what still we need to learn?
abstract: Antithyroid drugs (ATDs) induced agranulocytosis is a rare but life threatening condition. We report a 29 years Filipino female diagnosed as having hyperthyroidism with normal base line blood counts, liver and renal profile. She was started on maximum 60 mg (20mg TID) oral dose of carbimazole since one month by her treating physician. Exactly after one month of treatment she presented to emergency room (ER) with fever, sore throat and generalized weakness for several days.
authors.affiliation: Department of Internal Medicine, Pulmonary Division, Sultan Bin Abdulaziz Humanitarian City, Riyadh, Saudi Arabia.
authors.forename: Liaqat Ali
authors.initials: LA
authors.lastname: Chaudhry
authors.affiliation: Department of Anesthesia & Intensive Care Unit, Sultan Bin Abdulaziz Humanitarian City, Riyadh, Saudi Arabia.
authors.forename: Khalid Fouad
authors.initials: KF
authors.lastname: Mauzen
authors.affiliation: Department of Medicine & Endocrinology, Dammam Medical Complex (MOH), Saudi Arabia.
authors.forename: Ebtesam
authors.initials: E
authors.lastname: Ba-Essa
authors.affiliation: Department of Endocrinology and Diabetes, Diabetes Treatment Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
authors.forename: Asirvatham Alwin
authors.initials: AA
authors.lastname: Robert
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced*; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002231:Carbimazole / Q000009:adverse effects*; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy
chemical_list: D013956:Antithyroid Agents; D002231:Carbimazole
keywords: ATD-antithyroid drugs; Hyperthyroidism; agranulocytosis; granulocyte colony stimulating factor