title: A longitudinal study of immunological status in Chinese haemophiliacs: importance of the heat viral inactivation of factor concentrates. I. Immunological associations with the consumption of factor concentrates.
abstract: Twenty-four of 117 cases of haemophilia A (20.5%) and none of 18 cases of haemophilia B reported in this study had an antibody to the human immuno-deficiency virus (HIV). Both groups of patients showed similar immunological alterations. HIV-seropositive haemophilia A patients had an increased CD8 cell count and a similarly decreased CD4/CD8 ratio as compared to HIV-seronegative haemophilia A patients. Multiple regression analysis for the association of CD4/CD8 ratio with HIV infection status and dosage of plasma products in haemophilia A and B patients, respectively, revealed that there was a significant negative association of ln(CD4/CD8) with dosage of factor VlII concentrates (P = 0.0435) and factor IX concentrates (P = O.O028), respectively. N o association occurred between CD4/CD8 ratio and HIV infection as well as dosage of other plasma products. These data indicate that the immunological abnormalities of our haemophilia A and B patients in their early years were primarily caused by various viral infections and/or a suppressive effect of allogeneic protein through infusion of factor concentrates and not caused simply by HIV infection.
authors.affiliation: National Taiwan University Hospital, college of Medicine, National Taiiwan University, Taipei, Taiwan, Republic of China.
authors.forename: S
authors.initials: S
authors.lastname: Ming-Ching
authors.affiliation: National Taiwan University Hospital, college of Medicine, National Taiiwan University, Taipei, Taiwan, Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Fuei-Yuen
authors.affiliation: National Taiwan University Hospital, college of Medicine, National Taiiwan University, Taipei, Taiwan, Republic of China.
authors.forename: K
authors.initials: K
authors.lastname: Yen-Ping
authors.affiliation: National Taiwan University Hospital, college of Medicine, National Taiiwan University, Taipei, Taiwan, Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Ron-Fon
keywords: CD4/CD8 ratio; Chinese haemophiliacs; Keywords:; consumption of factor concentrates.; human immunodeficiency virus infection; immunological association; immunological status