title: Role of Presepsin for the Assessment of Acute Cholangitis Severity.
abstract: BACKGROUND
  Presepsin is a new emerging inflammatory biomarker. The primary purpose of this study was to elucidate the predictive usability of presepsin for severity assessment in patients with acute cholangitis (AC).
  
  
  METHODS
  A total of 119 treatment-naive patients with AC (64 males, 55 females) were enrolled in this study. Patients were classified with Grade I (mild), Grade II (moderate), or Grade III (severe) AC based on severity assessment guidelines. Presepsin concentrations were measured on admission.
  
  
  RESULTS
  The median presepsin concentrations were 297 pg/mL (interquartile range (IQR) 234 - 386 pg/mL), 590 pg/mL (IQR 559 - 619 pg/mL), and 857 pg/mL (IQR 740 - 960 pg/mL) in patients with mild, moderate, and severe AC, respectively. Presepsin concentrations were significantly higher in patients with severe AC than in patients with moderate AC (p < 0.01), and in patients with moderate AC than in patients with mild AC (p < 0.01). With the receiver operating characteristic (ROC) analysis, the areas under the curves (AUCs) for presepsin to discriminate patients with moderate and severe AC were 0.935 (95% confidence interval (CI) 0.877 to 0.993, p < 0.001) and 0.942 (95% CI 0.885 to 0.998, p < 0.001), respectively.
  
  
  CONCLUSIONS
  Compared with other conventional biochemical indicators such as WBC, CRP, and PCT, presepsin may be a useful parameter for the severity assessment of AC.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Lin
authors.forename: Huidong
authors.initials: H
authors.lastname: Sun
authors.forename: Jiangong
authors.initials: J
authors.lastname: Li
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Zheng
authors.forename: Cunhua
authors.initials: C
authors.lastname: Shao
authors.forename: Yang Hong
authors.initials: YH
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Chang
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D002761:Cholangitis / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D012372:ROC Curve
chemical_list: D018950:Lipopolysaccharide Receptors; D010446:Peptide Fragments; C000594167:presepsin protein, human; D002097:C-Reactive Protein