title: [The relationship of vitamin D receptor gene and blood lead: a meta-analysis].
abstract: OBJECTIVE
  The correlation of vitamin D receptor (VDR) gene polymorphism and blood lead level had been in doult, which allowed us to write this article.
  
  
  METHODS
  Relevant studies about the blood lead and VDR B/b gene polymorphism which published from 1979-2015, were searched in multiple bibliographic databases, such as: CNKI, Wanfang Database, PUBMED. Of the ten references selceted, three were divided into two groups which were classified as different researches, so there were thirteen studies in the meta-analysis. According to the level of blood lead, the studies were analyzed by three groups: normal group, low dose grou and high dose group. The analysis was performed by stata 12.0 software.
  
  
  RESULTS
  The blood lead level of VDR B/b genotype was significantly difference in all the three groups (P<0.05) , but there were apparent heterogeneity between normal group and low dose group (P<0.05, I(2)=84.2%; P<0.05, I(2)=88.9%) , except the high dose group (P>0.05, I(2)=12.7%) ; after adjusted, all showed no heterogeneity, and the results were still the same.
  
  
  CONCLUSIONS
  The genotype of VDR may be correlated with blood lead, and the levels of blood lead varied with different genetypes.
authors.affiliation: Department of Epidemiology and Statistics, Hebei Medical University, Shijiazhuang 050017, China.
authors.forename: Q Y
authors.initials: QY
authors.lastname: Dong
authors.forename: C X
authors.initials: CX
authors.lastname: Zhao
authors.forename: F Z
authors.initials: FZ
authors.lastname: Chen
authors.forename: H X
authors.initials: HX
authors.lastname: Ji
authors.forename: X N
authors.initials: XN
authors.lastname: Zhang
authors.forename: H Y
authors.initials: HY
authors.lastname: Hao
authors.forename: Z M
authors.initials: ZM
authors.lastname: Li
authors.forename: J G
authors.initials: JG
authors.lastname: Li
authors.forename: J X
authors.initials: JX
authors.lastname: Yuan
mesh_terms: D005838:Genotype; D006801:Humans; D007854:Lead; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human; D007854:Lead