title: Efficiency of Ozone Therapy in a Rat Model of Experimental Uveitis.
abstract: OBJECTIVE
  To investigate efficiency of ozone therapy in uveitis.
  
  
  METHODS
  A total of 24 albino Wistar rats were randomly assigned to four groups (n = 6); (a) control group; (b) sham group; (c) infliximab treatment group; (d) ozone therapy group. Vitreous haze scores of all groups were evaluated. Vitreous cytokine levels (TNF-α, IL-1, IL-6) measured by ELISA and eyes were enucleated for histopathologic examination.
  
  
  RESULTS
  According to vitreous haze scores, there was statistically significant inflammation in Group (b) compared with Group (a), and there was less inflammation in infliximab and ozone groups compared with Group (b) (p < 0.05). Cytokine levels in infliximab and ozone groups were lower but not statistically significant when compared with Group (b) (p > 0.05). There was significantly less inflammation in histopathologic examination in treatment groups when compared with the sham group (p < 0.05).
  
  
  CONCLUSIONS
  Clinical and histopathologic examination results indicate that systemic application of ozone may be efficient in the treatment of uveitis.
authors.affiliation: a Department of Ophthalmology , Anıttepe Military Dispansery , Ankara , Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Kaya
authors.affiliation: b Department of Ophthalmology , GATA Haydarpasa Training Hospital , Istanbul , Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Sonmez
authors.affiliation: b Department of Ophthalmology , GATA Haydarpasa Training Hospital , Istanbul , Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Kar
authors.affiliation: c Department of Pathology , GATA Haydarpasa Training Hospital , Istanbul , Turkey.
authors.forename: Aptullah
authors.initials: A
authors.lastname: Haholu
authors.affiliation: b Department of Ophthalmology , GATA Haydarpasa Training Hospital , Istanbul , Turkey.
authors.forename: Yıldıray
authors.initials: Y
authors.lastname: Yildirim
authors.affiliation: d Department of Biochemistry , Erzincan Military Hospital , Erzincan , Turkey.
authors.forename: Tuba
authors.initials: T
authors.lastname: Müftüoğlu
authors.affiliation: b Department of Ophthalmology , GATA Haydarpasa Training Hospital , Istanbul , Turkey.
authors.forename: Melih Hamdi
authors.initials: MH
authors.lastname: Ünal
mesh_terms: D000818:Animals; D018501:Antirheumatic Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D000069285:Infliximab / Q000627:therapeutic use; D007375:Interleukin-1 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D010083:Oxidants, Photochemical / Q000627:therapeutic use*; D010126:Ozone / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014605:Uveitis / Q000188:drug therapy* / Q000378:metabolism; D014822:Vitreous Body / Q000378:metabolism
chemical_list: D018501:Antirheumatic Agents; D007375:Interleukin-1; D015850:Interleukin-6; D010083:Oxidants, Photochemical; D014409:Tumor Necrosis Factor-alpha; D010126:Ozone; D000069285:Infliximab
keywords: Experimental uveitis; IL-1; IL-6; TNF-α; ozone therapy