title: Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture).
abstract: DNA molecules are not completely stable, they are subject to chemical or photochemical damage and errors that occur during DNA replication resulting in mismatched base pairs. Through mechanistic studies Paul Modrich showed how replication errors are corrected by strand-directed mismatch repair in Escherichia coli and human cells.
authors.affiliation: Howard Hughes Medical Institute and Department of Biochemistry, Duke University, Medical Center, Durham, NC, 27710, USA. modrich@biochem.duke.edu.
authors.forename: Paul
authors.initials: P
authors.lastname: Modrich
mesh_terms: D004247:DNA / Q000378:metabolism; D004265:DNA Helicases / Q000378:metabolism; D019175:DNA Methylation; D053843:DNA Mismatch Repair / Q000502:physiology*; D004926:Escherichia coli / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000378:metabolism; D006801:Humans; D000070957:MutL Protein Homolog 1 / Q000378:metabolism; D000070956:MutL Proteins / Q000378:metabolism; D051719:MutS DNA Mismatch-Binding Protein / Q000378:metabolism
chemical_list: D029968:Escherichia coli Proteins; D004247:DNA; D000070957:MutL Protein Homolog 1; D000070956:MutL Proteins; D051719:MutS DNA Mismatch-Binding Protein; D004265:DNA Helicases
keywords: DNA repair; Nobel lecture; endonucleases; mismatch