title: Metabolic improvement of morbid obese patients following Roux-en-Y gastric bypass surgery: A prospective study in Mashhad, Iran.
abstract: OBJECTIVE
  Obesity is one of the greatest public health concerns worldwide. Weight loss surgeries have been increased in recent decades due to the world's epidemic of obesity. The aim of this prospective study is investigating metabolic factors of morbid obese patients following Roux-en-Y gastric bypass surgery.
  
  
  METHODS
  This was a nonrandomized prospective cohort study conducted from 2010 to 2013 on 60 consecutive patients who had body mass index (BMI) of more than 40 kg/m(2) and met the surgical indication criteria of bariatric surgery. Upon discharge, patients were followed in outpatient clinic of Qaem Hospital, Mashhad, Iran, each 3 months for 12 months. Measurement of anthropometric and metabolic indices was done in each postoperative visit.
  
  
  RESULTS
  Mean BMI reduction was 15.26 ± 3.45 kg/m(2) in the patients with an average value of 28.84 ± 3.94 (range from 22 to 40 kg/m(2)), which was significantly lower than the base value (p < 0.001). After a 12-month follow up, patients had lower low-density lipoprotein, triglycerides, and total cholesterol (p < 0.001 for all the variables), while achieving a greater high-density lipoprotein (p = 0.004). An improvement was seen in all of hypertensive patients after a 3-month follow up and blood pressure remained within normal limit in further follow ups. Complete remission was observed in all the patients with obstructive sleep apnea.
  
  
  CONCLUSIONS
  It appears reasonable that multidisciplinary treatment including surgical alternatives should be concerned for all morbidly obese patients, considering high rate of failure of conservative medical therapy in this setting.
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Sahar
authors.initials: S
authors.lastname: Fallahi-Shahabad
authors.affiliation: Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang, Beijing, China.|Institute of Genetics and Developmental Biology, International College University of Chinese Academy of Science (IC-UCAS), West Beichen Road, Chaoyang, China.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Mazidi
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Tavasoli
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Rezaie
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Rohani
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Simindokht
authors.initials: S
authors.lastname: Habibzadeh
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Emadodin
authors.initials: E
authors.lastname: Darchini-Maragheh
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Zohreh Sadat Sang
authors.initials: ZS
authors.lastname: Sefidi
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Safarian
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.|Cardiovascular Research Center, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Majid Ghayour
authors.initials: MG
authors.lastname: Mobarhan
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Rajabi
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Abdolreza
authors.initials: A
authors.lastname: Norouzy
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Seyed Mohammad Reza
authors.initials: SM
authors.lastname: Parizadeh
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Saeid
authors.initials: S
authors.lastname: Akhlaghi
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Tavalaie
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Firouzi
authors.affiliation: Biochemistry and Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran. NematyM@mums.ac.ir.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Nematy
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass; D006801:Humans; D007492:Iran; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000378:metabolism* / Q000601:surgery*; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000378:metabolism
chemical_list: D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol
keywords: Metabolic improvement; Obese patients; Roux-en-Y gastric bypass surgery