title: Metal-catalyzed cycloisomerization as a powerful tool in the synthesis of complex sesquiterpenoids.
abstract: Covering: up to 2015Sesquiterpenoids are consistently attracting the interest of the scientific community due to their promising clinical profile as therapeutic agents. Cycloisomerization of enynes and dienes is a powerful tool in the hands of organic chemists to access them. In the last 20 years the field has witnessed remarkable advances, especially by revealing the capability of platinum and gold complexes to initiate such reactions. Nowadays, cycloisomerizations continue to enrich our knowledge with atom-economical routes and impressive cascades to reach more complex molecules. The current review covers the basic mechanistic aspects of metal catalysis in cycloisomerization reactions and their progress to the synthesis of selected complex sesquiterpenoids.
authors.affiliation: Laboratory of Organic Synthesis, Pharmathen S.A., Greece.
authors.forename: Christos I
authors.initials: CI
authors.lastname: Stathakis
authors.affiliation: Laboratory of Organic Synthesis, Pharmathen S.A., Greece.
authors.forename: Petros L
authors.initials: PL
authors.lastname: Gkizis
authors.affiliation: Department of Chemistry, Laboratory of Organic Chemistry, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece. alzograf@chem.auth.gr.
authors.forename: Alexandros L
authors.initials: AL
authors.lastname: Zografos
mesh_terms: D003500:Cyclization; D006046:Gold / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D009944:Organoplatinum Compounds / Q000737:chemistry; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D009942:Organometallic Compounds; D009944:Organoplatinum Compounds; D012717:Sesquiterpenes; D006046:Gold