title: Synthesis and Biological Activity of New [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones.
abstract: A series of novel 2-(N-pyrrolidino, N-piperidino or N-morpholino)-7-phenyl(α-furoyl or α-thienyl)-[1,3]thiazolo[4,5-d]pyridazinones 10a-c, 14-16a,b was synthesized in 78-87% yields via the reaction of methyl 5-benzoyl(α-furoyl or α-thienyl)-2-aminosubstituted-thiazol-4-carboxylates 9a-c, 13a-e with hydrazine. These new compounds have been tested for their in vivo analgesic and anti-inflammatory activities. All compounds have been characterized by (1)H-NMR, (13)C-NMR spectroscopy, and liquid chromatography-mass spectrometry.
authors.affiliation: Institute of Pharmacology and Toxicology, Eugene Pottier 14, 03057 Kiev, Ukraine.
authors.forename: Anatoly
authors.initials: A
authors.lastname: Demchenko
authors.affiliation: Institute of Pharmacology and Toxicology, Eugene Pottier 14, 03057 Kiev, Ukraine.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Bobkova
authors.affiliation: Institute of Pharmacology and Toxicology, Eugene Pottier 14, 03057 Kiev, Ukraine.
authors.forename: Oleh
authors.initials: O
authors.lastname: Yadlovskiy
authors.affiliation: Institute of Pharmacology and Toxicology, Eugene Pottier 14, 03057 Kiev, Ukraine.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Buchtiarova
authors.affiliation: Institute of Pharmacology and Toxicology, Eugene Pottier 14, 03057 Kiev, Ukraine.
authors.forename: Sergey
authors.initials: S
authors.lastname: Demchenko
keywords: Analgesic activity; Anti-inflammatory activity; In vivo tests; [1,3]Thiazolo[4,5-d]pyridazinones; «Acetic acid cramps» model; «Hot plate» model