title: High Resolution X-ray-Induced Acoustic Tomography.
abstract: Absorption based CT imaging has been an invaluable tool in medical diagnosis, biology, and materials science. However, CT requires a large set of projection data and high radiation dose to achieve superior image quality. In this letter, we report a new imaging modality, X-ray Induced Acoustic Tomography (XACT), which takes advantages of high sensitivity to X-ray absorption and high ultrasonic resolution in a single modality. A single projection X-ray exposure is sufficient to generate acoustic signals in 3D space because the X-ray generated acoustic waves are of a spherical nature and propagate in all directions from their point of generation. We demonstrate the successful reconstruction of gold fiducial markers with a spatial resolution of about 350 μm. XACT reveals a new imaging mechanism and provides uncharted opportunities for structural determination with X-ray.
authors.affiliation: Department of Radiation Oncology, School of Medicine, Stanford University, Stanford, CA 94305, USA.|Center for Bioengineering and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, USA.
authors.forename: Liangzhong
authors.initials: L
authors.lastname: Xiang
authors.affiliation: Center for Bioengineering and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, USA.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Tang
authors.affiliation: Department of Radiation Oncology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
authors.forename: Moiz
authors.initials: M
authors.lastname: Ahmad
authors.affiliation: Department of Radiation Oncology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Xing
mesh_terms: D000162:Acoustics; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D014054:Tomography / Q000379:methods*; D014965:X-Rays