title: [A Case of Squamous Cell Carcinoma of the Esophagus with Achalasia -- Conversion from Chemoradiotherapy to Surgery].
abstract: The patient was a 67-year-old woman with achalasia and squamous cell carcinoma(SCC)of the esophagus. She presented with a difficulty in swallowing. The cancer was on the surface of the esophagus. The patient initially received systemic chemotherapy with 5-FU and cisplatin, and radiation therapy. The difficulty in swallowing persisted due to insufficiency of radiation treatment caused by achalasia. Therefore, we shifted the treatment plan from chemoradiotherapy to surgery. Endoscopic examination performed before surgery showed that there was no obvious cancer in the esophagus. We resected the esophagus routinely. On the specimen, no cancer cells were detected upon macroscopic and microscopic examinations; metastasis was not detected in the lymph node. Achalasia is a recognized risk factor for esophageal SCC. In the treatment of superficial SCC, no difference of therapeutic effect was observed between surgery and chemoradiation. However, for the treatment of certain cases of SCC with achalasia, including the treatment of achalasia itself, surgery can be the preferred option of treatment.
authors.affiliation: Dept. of Surgery, Nagahama City Hospital.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Morimoto
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yata
authors.forename: Marika
authors.initials: M
authors.lastname: Nio
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Yonenaga
authors.forename: Kouji
authors.initials: K
authors.lastname: Hanaki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mise
authors.forename: Shunnichi
authors.initials: S
authors.lastname: Higashide
authors.forename: Yuuji
authors.initials: Y
authors.lastname: Kanda
authors.forename: Hideki
authors.initials: H
authors.lastname: Noda
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000628:therapy*; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D004931:Esophageal Achalasia / Q000209:etiology / Q000628:therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D009367:Neoplasm Staging
chemical_list: D002945:Cisplatin; D005472:Fluorouracil