title: A randomized comparative study of topical versus intravenous tranexamic acid administration in enhanced recovery after surgery (ERAS) total knee replacement.
abstract: BACKGROUND
  The aim of this study was to compare the topical to IV tranexamic acid (TXA) administration of the same dose, given at the same time in patients who underwent TKR using an enhanced recovery after surgery (ERAS) regime.
  
  
  METHODS
  Ninety patients were randomized in control group, and IV and topical application groups received 1 g TXA.
  
  
  RESULTS
  Blood loss and transfusion requirements in control group were statistically higher compared to both TXA groups (p < 0.05). Length of stay was the same in all groups.
  
  
  CONCLUSIONS
  TXA reduced significantly the blood loss and the need for transfusion in ERAS primary unilateral TKR.
authors.affiliation: Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, Dragana, 68100 Alexandroupolis, Greece.
authors.forename: Georgios I
authors.initials: GI
authors.lastname: Drosos
authors.affiliation: Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, Dragana, 68100 Alexandroupolis, Greece.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Ververidis
authors.affiliation: Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, Dragana, 68100 Alexandroupolis, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Valkanis
authors.affiliation: Department of Medical Statistics, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, Dragana, 68100 Alexandroupolis, Greece.
authors.forename: Grigorios
authors.initials: G
authors.lastname: Tripsianis
authors.affiliation: Department of Anesthesia, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, Dragana, 68100 Alexandroupolis, Greece.
authors.forename: Eftihios
authors.initials: E
authors.lastname: Stavroulakis
authors.affiliation: Department of Anesthesia, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, Dragana, 68100 Alexandroupolis, Greece.
authors.forename: Theodosia
authors.initials: T
authors.lastname: Vogiatzaki
authors.affiliation: Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, Dragana, 68100 Alexandroupolis, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Kazakos
keywords: Blood loss; Total knee replacement; Tourniquet; Tranexamic acid; Transfusion