title: Baclofen-induced neurotoxicity in a patient with end-stage renal disease.
abstract: Baclofen, predominantly excreted by the kidneys is accumulated in patients with renal insufficiency leading to the central nervous system toxicity. Here the author reports a patient with end-stage renal disease on maintenance hemodialysis (HD) who developed drowsiness and became unresponsive within a day after taking single 10 mg dose of baclofen. Patient improved completely after two sessions of HD.
authors.affiliation: Department of Nephrology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.
authors.forename: Hemachandar
authors.initials: H
authors.lastname: Radhakrishnan
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000150:complications*; D001418:Baclofen / Q000009:adverse effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D006435:Renal Dialysis
chemical_list: D001418:Baclofen