title: The polyvinylpyrrolidone functionalized rGO/Bi2S3 nanocomposite as a near-infrared light-responsive nanovehicle for chemo-photothermal therapy of cancer.
abstract: Recently, a combination of chemotherapy with photothermal therapy (PTT) has received great attention for the construction of a near infrared (NIR)-controlled drug-delivery system for synergistic treatment of cancer, ultimately resulting in the enhancement of the therapeutic efficacy of anticancer drugs. Here, we developed a novel system for synergistic cancer therapy based on bismuth sulfide (Bi2S3) nanoparticle-decorated graphene functionalized with polyvinylpyrrolidone (PVP) (named PVP-rGO/Bi2S3). The as-prepared PVP-rGO/Bi2S3 nanocomposite has a high storage capacity for anticancer drugs (∼500% for doxorubicin (DOX)) and simultaneously has perfect photothermal conversion efficiency in the NIR region. The results of the in vitro accumulative drug release test manifests that the PVP-rGO/Bi2S3 nanocomposite could be applied as a dual pH- and NIR-responsive nanotherapeutic carrier for the controlled release of DOX from DOX-loaded PVP-rGO/Bi2S3 (PVP-rGO/Bi2S3@DOX). Moreover, the treatment of both cancer cells (including Hela, MCF-7, HepG2 and BEL-7402 cells) and BEL-7402 tumor-bearing mice with the PVP-rGO/Bi2S3@DOX complex followed by NIR laser irradiation produces significantly greater inhibition of cancer cell growth than the treatment with NIR irradiation alone or DOX alone, exhibiting a synergistic antitumor effect. Furthermore, due to the obvious NIR and X-ray absorption ability, the PVP-rGO/Bi2S3 nanocomposite could be employed as a dual-modal contrast agent for both photoacoustic tomography and X-ray computed tomography imaging. In addition to the good biocompatibility, the PVP-rGO/Bi2S3 nanocomposite paves a potential way for the fabrication of theranostic agents for dual-modal imaging-guided chemo-photothermal combined cancer therapy.
authors.affiliation: School of Materials Science & Engineering, Zhengzhou University, Zhengzhou 450002, China. dongbinbin@zzu.edu.cn and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. yanliang@ihep.ac.cn zjgu@ihep.ac.cn.
authors.forename: Ruixia
authors.initials: R
authors.lastname: Dou
authors.affiliation: School of Materials Science & Engineering, Zhengzhou University, Zhengzhou 450002, China. dongbinbin@zzu.edu.cn and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. yanliang@ihep.ac.cn zjgu@ihep.ac.cn.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Du
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. yanliang@ihep.ac.cn zjgu@ihep.ac.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Bao
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. yanliang@ihep.ac.cn zjgu@ihep.ac.cn.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Dong
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. yanliang@ihep.ac.cn zjgu@ihep.ac.cn.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Zheng
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. yanliang@ihep.ac.cn zjgu@ihep.ac.cn.
authors.forename: Miao
authors.initials: M
authors.lastname: Yu
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. yanliang@ihep.ac.cn zjgu@ihep.ac.cn.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Yin
authors.affiliation: School of Materials Science & Engineering, Zhengzhou University, Zhengzhou 450002, China. dongbinbin@zzu.edu.cn.
authors.forename: Binbin
authors.initials: B
authors.lastname: Dong
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. yanliang@ihep.ac.cn zjgu@ihep.ac.cn.
authors.forename: Liang
authors.initials: L
authors.lastname: Yan
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. yanliang@ihep.ac.cn zjgu@ihep.ac.cn.
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Gu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007259:Infrared Rays; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053761:Nanocomposites / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010789:Phototherapy; D011205:Povidone / Q000737:chemistry*
chemical_list: D004317:Doxorubicin; D011205:Povidone