title: BDNF Val66Met polymorphism and peripheral protein levels in pediatric bipolar disorder and attention-deficit/hyperactivity disorder.
abstract: Frontiers between pediatric bipolar disorder (PBD) and attention-deficit/hyperactivity disorder (ADHD) are not well defined. Few studies have addressed potentially different neurobiological factors between the two disorders. Brain-derived neurotrophic factor (BDNF) has been increasingly recognized for its etiologic and prognostic role in adult bipolar disorder (BD) studies. This study aimed to examine the BDNF gene polymorphism and potential alterations in BDNF serum levels in the pediatric ADHD patients with or without comorbid BD illness.
  
  
  
  We assessed the non-synonymous single-nucleotide polymorphism in the BDNF gene (rs6265/Val66Met) and its serum levels in children and adolescents with BD comorbid with ADHD (BD + ADHD) and ADHD alone. Children and adolescents were assessed for psychiatric diagnoses using the Kiddie-Sads-Present and Lifetime Version (K-SADS-PL).
  
  
  
  Using Analysis of covariance (ancova) we detected a significant group effect (patients with BD + ADHD had higher serum levels than those with ADHD - F80,3 = 8.73, P = 0.005).
  
  
  
  Although the Val66Met polymorphism at the BDNF gene does not seem to play a significant role in children and adolescents with BD or ADHD, BDNF serum levels deserve further attention in future research on neurobiological aspects of BD and ADHD.
authors.affiliation: Juvenile Bipolar Disorder Outpatient Program (Programa para Crianças e Adolescentes com Transtorno Bipolar - ProCAB), Child and Adolescent Psychiatry Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.|Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.
authors.forename: C P
authors.initials: CP
authors.lastname: Zeni
authors.affiliation: Juvenile Bipolar Disorder Outpatient Program (Programa para Crianças e Adolescentes com Transtorno Bipolar - ProCAB), Child and Adolescent Psychiatry Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Tramontina
authors.affiliation: Bipolar Disorder Unit, Molecular Psychiatry Unit, National Institute for Translational Medicine, CNPq, Porto Alegre, Brazil.
authors.forename: B W
authors.initials: BW
authors.lastname: Aguiar
authors.affiliation: Department of Genetics and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Salatino-Oliveira
authors.affiliation: Juvenile Bipolar Disorder Outpatient Program (Programa para Crianças e Adolescentes com Transtorno Bipolar - ProCAB), Child and Adolescent Psychiatry Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: G F
authors.initials: GF
authors.lastname: Pheula
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.
authors.forename: A
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.|Bipolar Disorder Unit, Molecular Psychiatry Unit, National Institute for Translational Medicine, CNPq, Porto Alegre, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Stertz
authors.affiliation: ADHD Outpatient Program (PRODAH), Child and Adolescent Psychiatry Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: C R
authors.initials: CR
authors.lastname: Moreira Maia
authors.affiliation: Department of Genetics and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Hutz
authors.affiliation: Bipolar Disorder Unit, Molecular Psychiatry Unit, National Institute for Translational Medicine, CNPq, Porto Alegre, Brazil.
authors.forename: F P
authors.initials: FP
authors.lastname: Kapczinski
authors.affiliation: Juvenile Bipolar Disorder Outpatient Program (Programa para Crianças e Adolescentes com Transtorno Bipolar - ProCAB), Child and Adolescent Psychiatry Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.|ADHD Outpatient Program (PRODAH), Child and Adolescent Psychiatry Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.|National Institute of Developmental Psychiatry for Children and Adolescents, Porto Alegre, Brazil.
authors.forename: L A
authors.initials: LA
authors.lastname: Rohde
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D001714:Bipolar Disorder / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: adolescents; attention-deficit/hyperactivity disorder; bipolar disorder; brain-derived neurotrophic factor; children