title: Specific immunotherapy for rhinitis and asthma with a subcutaneous hypoallergenic high-dose house dust mite extract: results of a 9-month therapy.
abstract: Effectiveness of a 9-month specific immunotherapy with a subcutaneous hypoallergenic high-dose house dust mite extract to reduce allergic symptoms as perceived by patients and physicians was assessed.
  
  
  
  An observational, retrospective, multicenter study was carried out in patients diagnosed with asthma and/or rhinitis caused by house dust mites having started specific immunotherapy with Acaroid(®). Primary end point was perceived effectiveness.
  
  
  
  A total of 409 patients were included. According to physician-completed visual analogue scale, a 58.1% clinical improvement was observed. Patient-completed visual analogue scale showed a 69.8% clinical improvement. The need for unscheduled/emergency healthcare, as an indication of poor quality of life, showed a significant reduction.
  
  
  
  Our results confirm in a real-world setting the findings from randomized clinical trials of high-dose house dust mites allergoid immunotherapy with a subcutaneous hypoallergenic high-dose house dust mite extract.
authors.affiliation: Unit of Allergy, University Hospital of La Plana in Vila-Real, Vila-Real, Castellon, Spain.
authors.forename: David
authors.initials: D
authors.lastname: El-Qutob
authors.affiliation: Clínica Dr. Lobatón, Cádiz, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Moreno
authors.affiliation: Medical Affairs Department, Merck S.L., Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Subtil-Rodríguez
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000627:therapeutic use*; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D002457:Cell Extracts / Q000627:therapeutic use*; D003888:Desensitization, Immunologic / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D039981:Pyroglyphidae; D016032:Randomized Controlled Trials as Topic; D065631:Rhinitis, Allergic / Q000276:immunology / Q000628:therapy*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D039741:Antigens, Dermatophagoides; D002457:Cell Extracts
keywords: asthma; house dust mite; quality of life; rhinitis; specific immunotherapy