title: Effect of non-invasive remote ischemic preconditioning on intra-renal perfusion in volunteers.
abstract: Remote ischemic preconditioning may attenuate renal injury and protect the kidney during subsequent inflammatory or ischemic stress. However, the mechanism of such a protection is not well understood. The aim of this study was to investigate the impact of remote ischemic preconditioning on renal resistivity index (RRI) in nine healthy volunteers. In six volunteers, four cycles of 4-min inflation of a blood pressure cuff were applied to one upper arm, followed by 4-min reperfusion with the cuff deflated. RRI was determined using Doppler echography during each cuff deflated period. Measures were also performed in three volunteers without preconditioning. The median value of RRI significantly decreased progressively from 0.59 [0.53-0.62] before the remote conditioning (baseline) to 0.49 [0.46-0.53] at the end of the experiment (p < 0.001) whereas there was no change in controls. In this study, for the first time, we have clearly shown in a small group of subjects that remote ischemic preconditioning can induce a significantly decrease in RRI through increased intra-renal perfusion.
authors.affiliation: Service de Réanimation Médicale, University of Poitiers, CHU-Poitiers, CIC 1402, 86021, Poitiers Cedex, France. r.robert@chu-poitiers.fr.
authors.forename: René
authors.initials: R
authors.lastname: Robert
authors.affiliation: Service de Réanimation Médicale, University of Poitiers, CHU-Poitiers, CIC 1402, 86021, Poitiers Cedex, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Vinet
authors.affiliation: Service de Réanimation Médicale, University of Poitiers, CHU-Poitiers, CIC 1402, 86021, Poitiers Cedex, France.
authors.forename: Angéline
authors.initials: A
authors.lastname: Jamet
authors.affiliation: Service de Réanimation Médicale, University of Poitiers, CHU-Poitiers, CIC 1402, 86021, Poitiers Cedex, France.
authors.forename: Rémi
authors.initials: R
authors.lastname: Coudroy
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D019194:Ischemic Preconditioning / Q000295:instrumentation / Q000379:methods*; D008297:Male; D012039:Regional Blood Flow; D012079:Renal Circulation; D013997:Time Factors; D014111:Tourniquets; D018608:Ultrasonography, Doppler; D034941:Upper Extremity / Q000098:blood supply*; D014655:Vascular Resistance
keywords: Doppler; Ischemia–reperfusion; Renal injury; Resistivity index