title: dbCPG: A web resource for cancer predisposition genes.
abstract: Cancer predisposition genes (CPGs) are genes in which inherited mutations confer highly or moderately increased risks of developing cancer. Identification of these genes and understanding the biological mechanisms that underlie them is crucial for the prevention, early diagnosis, and optimized management of cancer. Over the past decades, great efforts have been made to identify CPGs through multiple strategies. However, information on these CPGs and their molecular functions is scattered. To address this issue and provide a comprehensive resource for researchers, we developed the Cancer Predisposition Gene Database (dbCPG, Database URL: http://bioinfo.ahu.edu.cn:8080/dbCPG/index.jsp), the first literature-based gene resource for exploring human CPGs. It contains 827 human (724 protein-coding, 23 non-coding, and 80 unknown type genes), 637 rats, and 658 mouse CPGs. Furthermore, data mining was performed to gain insights into the understanding of the CPGs data, including functional annotation, gene prioritization, network analysis of prioritized genes and overlap analysis across multiple cancer types. A user-friendly web interface with multiple browse, search, and upload functions was also developed to facilitate access to the latest information on CPGs. Taken together, the dbCPG database provides a comprehensive data resource for further studies of cancer predisposition genes.
authors.affiliation: Institute of Health Sciences, School of Computer Science and Technology, Anhui University, Hefei, Anhui, 230601, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Wei
authors.affiliation: Institute of Health Sciences, School of Computer Science and Technology, Anhui University, Hefei, Anhui, 230601, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Yao
authors.affiliation: College of Electrical Engineering and Automation, Anhui University, Hefei, Anhui, 230601, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Yang
authors.affiliation: College of Electrical Engineering and Automation, Anhui University, Hefei, Anhui, 230601, China.|Co-Innovation Center for Information Support and Assurance Technology, Anhui University, Hefei, Anhui, 230601, China.
authors.forename: Chun-Hou
authors.initials: CH
authors.lastname: Zheng
authors.affiliation: School of Engineering, Faculty of Science, Health, Education and Engineering, University of Sunshine Coast, Maroochydore DC, Queensland, 4558, Australia.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Institute of Health Sciences, School of Computer Science and Technology, Anhui University, Hefei, Anhui, 230601, China.|Co-Innovation Center for Information Support and Assurance Technology, Anhui University, Hefei, Anhui, 230601, China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Xia
mesh_terms: D000818:Animals; D019295:Computational Biology; D057225:Data Mining; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D005823:Genetics; D006801:Humans; D020407:Internet; D051379:Mice; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D051381:Rats
keywords: cancer predisposition gene; database; functional annotation; gene prioritization; network module