title: Risks and benefits HIV preexposure prophylaxis with tenofovir/emtricitabine in an older male with comorbidities.
abstract: Renal toxicity in a 73-year-old male, using tenofovir/emtricitabine as preexposure prophylaxis, is described. Reduced renal reserve, a higher exposure to comedications and comorbidities can present a challenge when assessing the risks and benefits of tenofovir-based preexposure prophylaxis in the ageing population.
authors.affiliation: aChelsea & Westminster Hospital NHS Foundation Trust, London, UK bDepartment of Medical Sciences and Surgery, Section of Infectious Diseases, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy cImperial College Healthcare NHS Foundation Trust dMedical Research Council, Clinical Trials Unit eImperial College London, London UK.
authors.forename: Nicolò
authors.initials: N
authors.lastname: Girometti
authors.forename: Rachael
authors.initials: R
authors.lastname: Jones
authors.forename: Jeremy
authors.initials: J
authors.lastname: Levy
authors.forename: Sheena
authors.initials: S
authors.lastname: McCormack
authors.forename: Ann
authors.initials: A
authors.lastname: Sullivan
authors.forename: Tristan J
authors.initials: TJ
authors.lastname: Barber
mesh_terms: D000368:Aged; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects*; D018890:Chemoprevention / Q000009:adverse effects* / Q000379:methods; D015897:Comorbidity; D000068679:Emtricitabine / Q000008:administration & dosage / Q000009:adverse effects*; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D065129:Pre-Exposure Prophylaxis / Q000379:methods*; D018570:Risk Assessment; D000068698:Tenofovir / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D019380:Anti-HIV Agents; D000068698:Tenofovir; D000068679:Emtricitabine