title: Current situation and future usage of anticancer drug databases.
abstract: Cancer is a deadly disease with increasing incidence and mortality rates and affects the life quality of millions of people per year. The past 15 years have witnessed the rapid development of targeted therapy for cancer treatment, with numerous anticancer drugs, drug targets and related gene mutations been identified. The demand for better anticancer drugs and the advances in database technologies have propelled the development of databases related to anticancer drugs. These databases provide systematic collections of integrative information either directly on anticancer drugs or on a specific type of anticancer drugs with their own emphases on different aspects, such as drug-target interactions, the relationship between mutations in drug targets and drug resistance/sensitivity, drug-drug interactions, natural products with anticancer activity, anticancer peptides, synthetic lethality pairs and histone deacetylase inhibitors. We focus on a holistic view of the current situation and future usage of databases related to anticancer drugs and further discuss their strengths and weaknesses, in the hope of facilitating the discovery of new anticancer drugs with better clinical outcomes.
authors.affiliation: College of Mathematics, Tonghua Normal University, Tonghua, 134002, China. whz-98@126.com.
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Yin
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
authors.forename: Peiqi
authors.initials: P
authors.lastname: Wang
authors.affiliation: College of Life Sciences, Sichuan University, Chengdu, 610064, China.|State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China.
authors.forename: Chenyu
authors.initials: C
authors.lastname: Xiong
authors.affiliation: College of Life Sciences, Sichuan University, Chengdu, 610064, China.|State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China.
authors.forename: Lingyu
authors.initials: L
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
authors.forename: Sijia
authors.initials: S
authors.lastname: Li
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Li
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China. leilei_fu@163.com.
authors.forename: Leilei
authors.initials: L
authors.lastname: Fu
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D062313:Databases, Pharmaceutical; D055808:Drug Discovery; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents
keywords: Anticancer drugs; Databases; Drug discovery; Targeted therapy