title: Alternating Poly(ester-anhydride) by Insertion Polycondensation.
abstract: We report on a synthetic method where polyanhydride is used as starting material and the ester monomers are inserted through complete esterification, leading to an alternating ester-anhydride copolymer. The molar ratio of ricinoleic acid (RA) and sebacic acid (SA) was optimized until polysebacic acid is completely converted to carboxylic acid-terminated RA-SA and RA-SA-RA ester-dicarboxylic acids. These dimers and trimers were activated with acetic anhydride, polymerized under heat and vacuum to yield alternating RA-SA copolymer. The resulting alternating poly(ester-anhydride) have the RA at regular intervals. The regular occurrences of RA side chains prevent anhydride interchange, enhancing hydrolytic stability, which allows storage of the polymer at room temperature.
authors.affiliation: School of Pharmacy, Institute of Drug Research, Hebrew University of Jerusalem , Jerusalem 9112001, Israel.
authors.forename: Moran
authors.initials: M
authors.lastname: Haim-Zada
authors.affiliation: School of Pharmacy, Institute of Drug Research, Hebrew University of Jerusalem , Jerusalem 9112001, Israel.
authors.forename: Arijit
authors.initials: A
authors.lastname: Basu
authors.affiliation: Dexcel Pharma Technologies, Ltd , Or-Akiva 30600000, Israel.
authors.forename: Tal
authors.initials: T
authors.lastname: Hagigit
authors.affiliation: Dexcel Pharma Technologies, Ltd , Or-Akiva 30600000, Israel.
authors.forename: Ron
authors.initials: R
authors.lastname: Schlinger
authors.affiliation: TAMI- Institute for Research & Development, Ltd , Haifa Bay 26111, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Grishko
authors.affiliation: TAMI- Institute for Research & Development, Ltd , Haifa Bay 26111, Israel.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kraminsky
authors.affiliation: TAMI- Institute for Research & Development, Ltd , Haifa Bay 26111, Israel.
authors.forename: Ezra
authors.initials: E
authors.lastname: Hanuka
authors.affiliation: School of Pharmacy, Institute of Drug Research, Hebrew University of Jerusalem , Jerusalem 9112001, Israel.
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Domb
mesh_terms: D000812:Anhydrides / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D003652:Decanoic Acids / Q000737:chemistry*; D003998:Dicarboxylic Acids / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012277:Ricinoleic Acids / Q000737:chemistry*
chemical_list: D000812:Anhydrides; D001672:Biocompatible Materials; D003652:Decanoic Acids; D003998:Dicarboxylic Acids; D004952:Esters; D046911:Macromolecular Substances; D011108:Polymers; D012277:Ricinoleic Acids; C011107:sebacic acid; C030521:ricinoleic acid