title: Cyclin-Dependent Kinase Co-Ordinates Carbohydrate Metabolism and Cell Cycle in S. cerevisiae.
abstract: Cyclin-dependent kinases (CDKs) control cell division in eukaryotes by phosphorylating proteins involved in division. But successful proliferation requires co-ordination between division and cellular growth in mass. Previous proteomic studies suggested that metabolic proteins, as well as cell division proteins, could potentially be substrates of cyclin-dependent kinases. Here we focus on two metabolic enzymes of the yeast S. cerevisiae, neutral trehalase (Nth1) and glycogen phosphorylase (Gph1), and show that their activities are likely directly controlled by CDK activity, thus allowing co-ordinate regulation of carbohydrate metabolism with cell division processes. In this case, co-ordinate regulation may optimize the decision to undertake a final cell division as nutrients are being exhausted. Co-regulation of cell division processes and metabolic processes by CDK activity may be a general phenomenon important for co-ordinating the cell cycle with growth.
authors.affiliation: Department of Molecular Genetics & Microbiology, Stony Brook University, Stony Brook, NY 11794, USA.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
authors.affiliation: Department of Molecular Genetics & Microbiology, Stony Brook University, Stony Brook, NY 11794, USA; Graduate Program in Genetics, Stony Brook University, Stony Brook, NY 11794, USA.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Molecular Genetics & Microbiology, Stony Brook University, Stony Brook, NY 11794, USA.
authors.forename: Lucas
authors.initials: L
authors.lastname: Carey
authors.affiliation: Department of Molecular Genetics & Microbiology, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address: bfutcher@gmail.com.
authors.forename: Bruce
authors.initials: B
authors.lastname: Futcher
mesh_terms: D017489:CDC28 Protein Kinase, S cerevisiae / Q000235:genetics / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D002453:Cell Cycle; D004734:Energy Metabolism; D005838:Genotype; D006003:Glycogen / Q000378:metabolism; D024981:Glycogen Phosphorylase / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013997:Time Factors; D014198:Trehalase / Q000235:genetics / Q000378:metabolism; D014199:Trehalose / Q000378:metabolism
chemical_list: D029701:Saccharomyces cerevisiae Proteins; D006003:Glycogen; D014199:Trehalose; D024981:Glycogen Phosphorylase; D017489:CDC28 Protein Kinase, S cerevisiae; C000614366:NTH1 protein, S cerevisiae; D014198:Trehalase