title: Endostatin is higher and associated with pulmonary involvement in primary Sjögren's syndrome.
abstract: OBJECTIVE
  To investigate serum levels of endostatin in a well characterised cohort of patients with primary Sjögren's syndrome (pSS) and healthy controls (HC) and assess associations between these mediators and clinical parameters.
  
  
  METHODS
  All patients (n=144) were recruited from the Norwegian systemic connective tissue disease and vasculitis registry (NOSVAR) and fulfilled American-European classification criteria for pSS. Pulmonary involvement was based on clinical symptoms and abnormal findings on high-resolution computed tomography of the lungs. The controls were 100 healthy blood donors. Serum levels of endostatin was determined by enzyme immunoassay.
  
  
  RESULTS
  We found higher mean levels of serum endostatin in patients with pSS compared with the controls (p<0.001). The patients with interstitial lung disease (ILD) had higher levels compared with those without pulmonary involvement.
  
  
  CONCLUSIONS
  Our results indicate that endostatin is increased in patients with pSS and particularly in those with ILD.
authors.affiliation: Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway. opalm@ous-hf.no.
authors.forename: Øyvind
authors.initials: Ø
authors.lastname: Palm
authors.affiliation: Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet; and Institute of Clinical Medicine, University of Oslo, Norway.
authors.forename: Thor
authors.initials: T
authors.lastname: Ueland
authors.affiliation: Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Torhild
authors.initials: T
authors.lastname: Garen
authors.affiliation: Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet; and Institute of Clinical Medicine, University of Oslo, Norway.
authors.forename: Annika E
authors.initials: AE
authors.lastname: Michelsen
authors.affiliation: Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Silje
authors.initials: S
authors.lastname: Reiseter
authors.affiliation: Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet; Institute of Clinical Medicine, University of Oslo; and Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, Norway.
authors.forename: Pål
authors.initials: P
authors.lastname: Aukrust
authors.affiliation: Department of Radiology and Nuclear Medicine, Oslo University Hospital Rikshospitalet, Norway.
authors.forename: Trond Mogens
authors.initials: TM
authors.lastname: Aaløkken
authors.affiliation: Department of Rheumatology, Oslo University Hospital Rikshospitalet; and Institute of Clinical Medicine, University of Oslo, Norway.
authors.forename: Øyvind
authors.initials: Ø
authors.lastname: Molberg
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D043169:Endostatins / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009664:Norway; D012042:Registries; D012859:Sjogren's Syndrome / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D014057:Tomography, X-Ray Computed; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D043169:Endostatins