title: Neurotrophins and their Trk-receptors in the cerebellum of zebrafish.
abstract: Neurotrophins (NTs) and their specific Trk-receptors are key molecules involved in the regulation of survival, proliferation, and differentiation of central nervous system during development and adulthood in vertebrates. In the present survey, we studied the expression and localization of neurotrophins and their Trk-receptors in the cerebellum of teleost fish Danio rerio (zebrafish). Teleostean cerebellum is composed of a valvula, body and vestibulolateral lobe. Valvula and body show the same three-layer structure as cerebellar cortex in mammals. The expression of NTs and Trk-receptors in the whole brain of zebrafish has been studied by Western blotting analysis. By immunohistochemistry, the localization of NTs has been observed mainly in Purkinje cells; TrkA and TrkB-receptors in cells and fibers of granular and molecular layers. TrkC was faintly detected. The occurrence of NTs and Trk-receptors suggests that they could have a synergistic action in the cerebellum of zebrafish. J. Morphol. 277:725-736, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Gatta
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy.
authors.forename: Gennaro
authors.initials: G
authors.lastname: Altamura
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Avallone
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy.
authors.forename: Luciana
authors.initials: L
authors.lastname: Castaldo
authors.affiliation: Institute of Protein Biochemistry, CNR, Naples, Italy.
authors.forename: Annunziata
authors.initials: A
authors.lastname: Corteggio
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy.
authors.forename: Livia
authors.initials: L
authors.lastname: D'Angelo
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: de Girolamo
authors.affiliation: Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Lucini
mesh_terms: D000818:Animals; D015153:Blotting, Western; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D009414:Nerve Growth Factors / Q000378:metabolism*; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*; D015027:Zebrafish / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000378:metabolism*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D017475:Receptors, Nerve Growth Factor; D029961:Zebrafish Proteins
keywords: Brain; fish; neurotrophic factors; teleosts