title: Novel aspects of platelet factor XIII function.
abstract: Pools of factor XIII (FXIII) exist in the plasma and within the cytoplasm of hematopoietic cells, including platelets. The functions of the cellular form, FXIII-A, have been assumed to be intracellular in nature, as the protein lacks a signal sequence for its release. Mounting evidence now suggests that platelet FXIII-A modulates hemostasis by several different mechanisms. In this condensed review we discuss recent advances in our understanding of the novel intracellular and extracellular functions of platelet FXIII-A.
authors.affiliation: Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
authors.forename: Joanne L
authors.initials: JL
authors.lastname: Mitchell
authors.affiliation: Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK. Electronic address: n.j.mutch@abdn.ac.uk.
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Mutch
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D005176:Factor XIII / Q000378:metabolism*; D005337:Fibrin / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D015539:Platelet Activation; D000979:alpha-2-Antiplasmin / Q000378:metabolism
chemical_list: D000979:alpha-2-Antiplasmin; D005337:Fibrin; D005176:Factor XIII
keywords: factor XIII; fibrin; fibrinolysis; platelets; α(2)-antiplasmin