title: Toxic Effects of Bromothalonil and Flutolanil on Multiple Developmental Stages in Zebrafish.
abstract: In this study, we applied various developmental stages of zebrafish to address the potential environmental risk and aquatic toxicity of bromothalonil and flutolanil. This results demonstrated that the acute toxicity of bromothalonil to the three phases of zebrafish were 4.34 (embryo) < 3.27 (12 h old larvae) < 2.52 mg/L (adult fish) and that of flutolanil were 5.47 (embryo) < 4.09 (72 h old larvae) < 3.91 (12 h old larvae) < 2.70 mg/L (adult). Sublethal effects induced by both bromothalonil and flutolanil on zebrafish embryos were noted, including growth inhibition, abnormal spontaneous movement, slower heart rate, complete hatching failure, and morphological deformities. In addition, both bromothalonil and flutolanil could cause notochord deformation and short body length of larvae. This study provides a foundation for future investigation into the mechanism of bromothalonil and flutolanil toxicity in zebrafish.
authors.affiliation: College of Sciences, China Agricultural University, No. 2 Yuan Mingyuan West Road, Haidian District, Beijing, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: College of Sciences, China Agricultural University, No. 2 Yuan Mingyuan West Road, Haidian District, Beijing, People's Republic of China.
authors.forename: Suzhen
authors.initials: S
authors.lastname: Qi
authors.affiliation: College of Sciences, China Agricultural University, No. 2 Yuan Mingyuan West Road, Haidian District, Beijing, People's Republic of China.
authors.forename: Jiayi
authors.initials: J
authors.lastname: Chen
authors.affiliation: College of Sciences, China Agricultural University, No. 2 Yuan Mingyuan West Road, Haidian District, Beijing, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Sciences, China Agricultural University, No. 2 Yuan Mingyuan West Road, Haidian District, Beijing, People's Republic of China.
authors.forename: Miao
authors.initials: M
authors.lastname: Teng
authors.affiliation: College of Sciences, China Agricultural University, No. 2 Yuan Mingyuan West Road, Haidian District, Beijing, People's Republic of China. Wangchengju@cau.edu.cn.
authors.forename: Chengju
authors.initials: C
authors.lastname: Wang
mesh_terms: D000813:Anilides / Q000633:toxicity*; D000818:Animals; D004625:Embryo, Nonmammalian / Q000187:drug effects; D005659:Fungicides, Industrial / Q000633:toxicity*; D007814:Larva / Q000187:drug effects / Q000254:growth & development / Q000502:physiology; D009570:Nitriles / Q000633:toxicity*; D015027:Zebrafish / Q000196:embryology / Q000254:growth & development / Q000502:physiology*
chemical_list: D000813:Anilides; D005659:Fungicides, Industrial; D009570:Nitriles; C475882:flutolanil; C039411:1,2-dibromo-2,4-dicyanobutane
keywords: Bromothalonil; Flutolanil; Morphological deformities; Toxicity; Zebrafish