title: New Insight into Effects of β-Blockers on Arterial Functions.
abstract: The effects of β-blockers on arterial properties are not well investigated. In our recent study, we compared the effects of the two β-blockers celiprolol and bisoprolol on blood pressure, baroreflex sensitivity (BRS), flow-mediated vasodilatation, and vascular stiffness. We found that bisoprolol achieved a greater reduction in the pulse rate and improved BRS and vascular stiffness, whereas celiprolol reduced the central blood pressure level. In this review, the mechanisms of different types of β-blockers and their effects on arteries are discussed, and the appropriate use of β-blockers in hypertensive subjects will be proposed.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Eguchi
keywords: Ambulatory blood pressure; Bisoprolol; Celiprolol; Central blood pressure; Flow-mediated vasodilation; Home blood pressure; Pulse wave velocity; Urinary albumin excretion ratio