title: Impact of parathyroidectomy for primary hyperparathyroidism on quality of life: A case-control study using Short Form Health Survey 36.
abstract: Physical and mental complaints are common in patients with primary hyperparathyroidism (PHPT) and negatively impact quality of life (QOL). Subjective symptoms in current guidelines are not considered an indication for surgery. The purpose of this study was to assess the effect of parathyroidectomy on QOL in patients with PHPT.
  
  
  
  This multicenter case-control study investigated preoperative and postoperative QOL scores in patients operated for PHPT, measured with the Short Form Health Survey-36 (SF-36) questionnaire. Results were compared with patients undergoing a hemithyroidectomy, the control group.
  
  
  
  Fifty-two patients and 49 controls were included. Patients with PHPT had significantly lower QOL scores preoperatively and improved significantly after successful surgical treatment. Postoperatively, no differences were observed between the 2 groups.
  
  
  
  QOL was significantly lower in patients with untreated PHPT. Surgical treatment was associated with a significant increase in QOL. Decreased QOL should also be considered as an indicator for surgical treatment in patients with PHPT. © 2016 Wiley Periodicals, Inc. Head Neck 38:1213-1220, 2016.
authors.affiliation: Department of Surgery, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Roderick
authors.initials: R
authors.lastname: Dulfer
authors.affiliation: Department of Surgery, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Wanda
authors.initials: W
authors.lastname: Geilvoet
authors.affiliation: Department of Surgery, Groene Hart Ziekenhuis, Gouda, The Netherlands.
authors.forename: Annelien
authors.initials: A
authors.lastname: Morks
authors.affiliation: Department of Surgery, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Esther M M
authors.initials: EM
authors.lastname: van Lieshout
authors.affiliation: Department of Surgery, Reinier de Graaf Groep (RDGG) Hospital, Delft, The Netherlands (retired).
authors.forename: Casper P C
authors.initials: CP
authors.lastname: Smit
authors.affiliation: Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Els J M
authors.initials: EJ
authors.lastname: Nieveen van Dijkum
authors.affiliation: Department of Surgery, Flevoziekenhuis, Almere, The Netherlands.
authors.forename: Klaas
authors.initials: K
authors.lastname: In't Hof
authors.affiliation: Dutch Cancer Institute, Amsterdam, The Netherlands.
authors.forename: Frits
authors.initials: F
authors.lastname: van Dam
authors.affiliation: Department of Surgery, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Casper H J
authors.initials: CH
authors.lastname: van Eijck
authors.affiliation: Department of Surgery, Reinier de Graaf Groep (RDGG) Hospital, Delft, The Netherlands (retired).
authors.forename: Peter W
authors.initials: PW
authors.lastname: de Graaf
authors.affiliation: Department of Surgery, Reinier de Graaf Groep (RDGG) Hospital, Delft, The Netherlands (retired).
authors.forename: Tessa M
authors.initials: TM
authors.lastname: van Ginhoven
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000503:physiopathology / Q000523:psychology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016105:Parathyroidectomy / Q000379:methods* / Q000523:psychology; D017060:Patient Satisfaction; D011184:Postoperative Period; D057234:Preoperative Period; D011379:Prognosis; D011788:Quality of Life; D012016:Reference Values; D012720:Severity of Illness Index; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
keywords: humans; parathyroidectomy/methods; primary hyperparathyroidism; primary/surgery; quality of life