title: Effects of aluminum oxide (Al2O3) nanoparticles on ECG, myocardial inflammatory cytokines, redox state, and connexin 43 and lipid profile in rats: possible cardioprotective effect of gallic acid.
abstract: The objectives of present study were to examine the effects of aluminum oxide (Al2O3) nanoparticles on myocardial functions, electrical activities, morphology, inflammation, redox state, and myocardial expression of connexin 43 (Cx43) and the effect of gallic acid (GA) on these effects in a rat animal model. Forty male albino rats were divided into 4 equal groups: the control (normal) group; the Al2O3 group, rats received Al2O3 (30 mg·kg(-1), i.p.) daily for 14 days; the nano-alumina group, rats received nano-alumina (30 mg·kg(-1), i.p.) daily for 14 days; and the nano-alumina + GA group, rats received GA (100 mg·kg(-1) orally once daily) for 14 days before nano-alumina administration. The results showed disturbed ECG variables and significant increases in serum levels of LDH, creatine phosphokinase (CPK), CK-MB, triglycerides (TGs), cholesterol and LDL, nitric oxide (NO), and TNF-α and myocardial concentrations of NO, TNF-α, and malondialdehyde (MDA), with significant decreases in serum HDL and myocardial GSH, SOD, catalase (CAT), and Cx43 expression in the nano-alumina group. Pretreatment with GA improved significantly all parameters except serum and myocardial NO. We concluded that chronic administration of Al2O3 NPs caused myocardial dysfunctions, and pretreatment with GA ameliorates myocardial injury induced by nano-alumina, probably through its hypolipidaemic, anti-inflammatory, and antioxidant effects and upregulation of Cx43 in heart.
authors.affiliation: a Department of Physiology, Faculty of Medicine, Kafrelsheikh University, Egypt.
authors.forename: El-Hussainy M A
authors.initials: el-HM
authors.lastname: El-Hussainy
authors.affiliation: b Department of Physiology, Faculty of Medicine, Mansoura University, Egypt.
authors.forename: Abdelaziz M
authors.initials: AM
authors.lastname: Hussein
authors.affiliation: c Department of Pathology, Faculty of Medicine, Mansoura University, Egypt.
authors.forename: Azza
authors.initials: A
authors.lastname: Abdel-Aziz
authors.affiliation: d Department of Inorganic Chemistry, Faculty of Science, Kafrelsheikh University, Egypt.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: El-Mehasseb
mesh_terms: D000537:Aluminum Oxide / Q000633:toxicity*; D000818:Animals; D009202:Cardiomyopathies / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control; D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D018031:Connexin 43 / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D016207:Cytokines / Q000097:blood; D004562:Electrocardiography / Q000187:drug effects; D005707:Gallic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D053758:Nanoparticles / Q000633:toxicity*; D010084:Oxidation-Reduction / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002316:Cardiotonic Agents; D018031:Connexin 43; D016207:Cytokines; D018836:Inflammation Mediators; D008055:Lipids; D005707:Gallic Acid; D000537:Aluminum Oxide
keywords: Cx43; ECG; TNF-α; acide gallique; cardiac enzymes; dyslipidemia; dyslipémie; enzymes cardiaques; gallic acid; nano-alumina; nano-alumine; oxidative stress; stress oxydant