title: Dentate nucleus iron deposition is a potential biomarker for tremor-dominant Parkinson's disease.
abstract: Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder with variable clinicopathologic phenotypes and underlying neuropathologic mechanisms. Each clinical phenotype has a unique set of motor symptoms. Tremor is the most frequent initial motor symptom of PD and is the most difficult symptom to treat. The dentate nucleus (DN) is a deep iron-rich nucleus in the cerebellum and may be involved in PD tremor. In this study, we test the hypothesis that DN iron may be elevated in tremor-dominant PD patients using quantitative susceptibility mapping. Forty-three patients with PD [19 tremor dominant (TD)/24 akinetic rigidity (AR) dominant] and 48 healthy gender- and age-matched controls were recruited. Multi-echo gradient echo data were collected for each subject on a 3.0-T MR system. Inter-group susceptibility differences in the bilateral DN were investigated and correlations of clinical features with susceptibility were also examined. In contrast with the AR-dominant group, the TD group was found to have increased susceptibility in the bilateral DN when compared with healthy controls. In addition, susceptibility was positively correlated with tremor score in drug-naive PD patients. These findings indicate that iron load within the DN may make an important contribution to motor phenotypes in PD. Moreover, our results suggest that TD and AR-dominant phenotypes of PD can be differentiated on the basis of the susceptibility of the DN, at least at the group level. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Naying
authors.initials: N
authors.lastname: He
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Huang
authors.affiliation: Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Huawei
authors.initials: H
authors.lastname: Ling
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Langley
authors.affiliation: Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, USA.|Department of Radiology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Chunlei
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Ding
authors.affiliation: Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Hongmin
authors.initials: H
authors.lastname: Xu
authors.affiliation: MR Research, Ge Healthcare, Shanghai, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: MR Research, Ge Healthcare, Shanghai, China.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Shengdi
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Fuhua
authors.initials: F
authors.lastname: Yan
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002529:Cerebellar Nuclei / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D056324:Diffusion Tensor Imaging / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D057054:Molecular Imaging / Q000379:methods*; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D014202:Tremor / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology
chemical_list: D015415:Biomarkers
keywords: Parkinson's disease; akinetic rigidity-dominant phenotype; iron deposition; quantitative susceptibility mapping; tremor-dominant phenotype