title: Detection of small bleeds in the brain with electrical impedance tomography.
abstract: In this paper, we describe and assess feasibility of instrumentation and algorithms for detecting bleeding due to hemorrhagic strokes and traumatic brain injury using electrical impedance tomography, a novel biomedical diagnostic modality in which the body is probed noninvasively with generally imperceptible alternating currents applied in patterns to a set of electrodes placed in contact with the skin. We focus on the GENESIS instrument developed by GE Global Research and on the achievability of our goal to detect a bleed in the center of the head with a volume of several ml. Our main topic is compensation for the large changes in voltages that tend to occur when the electrodes are in contact with biological media, specifically either human subjects or with vegetable matter proxies which seem to exhibit the same 'drift' phenomenon. We show that these changes in voltages can be modeled by assuming that each electrode is attached to the body via a discrete complex impedance whose value is time-varying and describe how this discrete component value can be estimated and largely compensated-for. We compare this discrete model with changes in contact impedances estimated using the complete electrode model showing that the two models are roughly comparable in their ability to explain the data from a single human subject experiment with electrodes attached to the head. In a simulation study, we demonstrate that it is possible to detect a small bleed in the center of the head even in the case of large changes in electrode impedances, which can be treated as nuisance parameters.
authors.forename: Gregory
authors.initials: G
authors.lastname: Boverman
authors.forename: Tzu-Jen
authors.initials: TJ
authors.lastname: Kao
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Ashe
authors.forename: David M
authors.initials: DM
authors.lastname: Davenport
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Amm
mesh_terms: D000465:Algorithms; D019540:Area Under Curve; D001921:Brain / Q000000981:diagnostic imaging*; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging*; D029773:Citrullus; D003198:Computer Simulation; D017097:Electric Impedance; D004566:Electrodes; D005240:Feasibility Studies; D005782:Gels; D006801:Humans; D008962:Models, Theoretical; D009010:Monte Carlo Method; D012372:ROC Curve; D014054:Tomography / Q000295:instrumentation* / Q000379:methods*
chemical_list: D005782:Gels