title: Investigation of endocrine and immunological response in fat tissue to hyperbaric oxygen administration in rats.
abstract: Though HBO treatment is becoming more common, the mechanism of action is not fully known. The positive effects of HBO administration on the inflammatory response is thought to be a possible basic mechanism. As a result, we aimed to research whether endocrine and immunological response of fat tissue changes in rats given HBO treatment model. This research was carried out on Wistar albino rats, they were treated with hyperbaric oxygen therapy. Their fatty tissue were taken from the abdomen, gene expression of the cytokines and adipokines were analyzed with Real time PCR method. When the gene expression of hormones and cytokines by fat tissue was examined, the leptin, visfatin, TNF-α, IL-1β and IL-10 levels in the HBO treatment group were statistically significantly increased compared to the control group (p=0.0313, p=0.0156, p=0.0156, p=0.0156, p=0.0313). In conclusion, in our study we identified that HBO administration affected the endochrinological functions of fat tissue.
authors.affiliation: Çanakkale Onsekiz Mart University Medical Faculty, Department of İnternal Medicine Çanakkale Turkey hcrgrsy@hotmail.com.
authors.forename: H
authors.initials: H
authors.lastname: Şen
authors.affiliation: Çanakkale Onsekiz Mart University Medical Faculty, Department of İnternal Medicine Çanakkale Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Erbağ
authors.affiliation: Çanakkale Onsekiz Mart University Medical Faculty, Department of Physiology Çanakkale Turkey.
authors.forename: M A
authors.initials: MA
authors.lastname: Ovali
authors.affiliation: Çanakkale Onsekiz Mart University Medical Faculty, Department of Biophysics Çanakkale Turkey.
authors.forename: R Ö
authors.initials: RÖ
authors.lastname: Öztopuz
authors.affiliation: Çanakkale Onsekiz Mart University Medical Faculty, Department of Physiology Çanakkale Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Uzun
mesh_terms: D000273:Adipose Tissue / Q000276:immunology*; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004703:Endocrine System / Q000276:immunology*; D006728:Hormones / Q000378:metabolism; D006931:Hyperbaric Oxygenation; D017208:Rats, Wistar
chemical_list: D016207:Cytokines; D006728:Hormones