title: Evaluation of a disease state management guideline for urinary tract infection.
abstract: A urinary tract infection (UTI) disease state management guideline, including risk-based antimicrobial recommendations, Foley catheter management and transitions of care, was implemented. This study evaluated the outcomes associated with implementation of the guideline. A retrospective study was conducted between 1 July 2013 and 30 September 2013 (pre-implementation) and between 1 July 2014 and 30 September 2014 (post-implementation). Symptomatic patients treated for UTI within 24 h with an identified pathogen were included. Risk-based patient groups were community-acquired UTI, healthcare-associated UTI, or extended-spectrum β-lactamase (ESBL) history in prior 12 months. Recommended antimicrobials were ceftriaxone, cefepime ± vancomycin, or doripenem ± vancomycin, respectively. Given the low post-implementation guideline adherence, pre- and post-groups were combined to evaluate potential guideline value. Length of stay (LOS) decreased when guidelines were followed [5 (IQR 4-7) days vs. 6 (IQR 4-8) days; P = 0.03] or appropriate therapy (according to in vitro susceptibilities) was given [5 (IQR 4-7) days vs. 6 (IQR 4-9) days; P = 0.03]. Those receiving guideline-recommended antimicrobials were more likely to have appropriate therapy within 24 h (84.4% vs. 64.2%; P <0.001). On multivariate analysis, intensive care unit (ICU) admission and admission from home were associated with longer and shorter LOS, respectively. Despite less than anticipated adherence, these data suggest that the established disease state management guideline can improve outcomes in patients admitted with UTI.
authors.affiliation: Department of Pharmacy, Hartford Hospital, 80 Seymour St., Hartford, CT 06102, USA.
authors.forename: Monika T
authors.initials: MT
authors.lastname: Zmarlicka
authors.affiliation: Department of Pharmacy, Hartford Hospital, 80 Seymour St., Hartford, CT 06102, USA.
authors.forename: Sophia M
authors.initials: SM
authors.lastname: Cardwell
authors.affiliation: Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour St., Hartford, CT 06102, USA.
authors.forename: Jared L
authors.initials: JL
authors.lastname: Crandon
authors.affiliation: Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour St., Hartford, CT 06102, USA.
authors.forename: David P
authors.initials: DP
authors.lastname: Nicolau
authors.affiliation: Department of Medicine, Hartford Hospital, 80 Seymour St., Hartford, CT 06102, USA.
authors.forename: Mitchell H
authors.initials: MH
authors.lastname: McClure
authors.affiliation: Department of Pharmacy, Hartford Hospital, 80 Seymour St., Hartford, CT 06102, USA; University of Connecticut School of Pharmacy, 69 N. Eagleville Road, Storrs, CT 06269, USA. Electronic address: Michael.nailor@hhchealth.org.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Nailor
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000628:therapy; D003428:Cross Infection / Q000175:diagnosis / Q000628:therapy; D019468:Disease Management; D005260:Female; D019983:Guideline Adherence; D006302:Health Services Research; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D064872:Patient Care Bundles; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000175:diagnosis* / Q000628:therapy*
keywords: Antibiogram; Bundle; Urinary tract infection