title: Ablative non-sequential fractional ultrapulsed CO2laser pretreatment improves conventional photodynamic therapy with methyl aminolevulinate in a novel human in vitro 3D actinic keratosis skin model.
authors.affiliation: Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Aachen, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Huth
authors.affiliation: Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Aachen, Germany.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Marquardt
authors.affiliation: Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Aachen, Germany.
authors.forename: Philipp M
authors.initials: PM
authors.lastname: Amann
authors.affiliation: Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Aachen, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Leverkus
authors.affiliation: Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Aachen, Germany.
authors.forename: Laura
authors.initials: L
authors.lastname: Huth
authors.affiliation: Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Aachen, Germany.
authors.forename: Jens M
authors.initials: JM
authors.lastname: Baron
authors.affiliation: Department of Dermatology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Gerber
mesh_terms: D000622:Aminolevulinic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D006801:Humans; D055623:Keratosis, Actinic / Q000188:drug therapy*; D053685:Laser Therapy / Q000379:methods; D054020:Lasers, Gas / Q000627:therapeutic use*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*
chemical_list: D017319:Photosensitizing Agents; C475457:methyl 5-aminolevulinate; D000622:Aminolevulinic Acid
keywords:  3D actinic keratosis skin model; ablative fractional laser treatment; laser-assisted drug delivery; methyl aminolevulinate; photodynamic therapy