title: Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases.
abstract: Neurodegenerative diseases are becoming an ever-increasing problem in aging populations. Low levels of brain-derived neurotrophic factor (BDNF) have previously been associated with the pathogenesis of numerous neurodegenerative diseases. Recently, microRNAs (miRNAs) have been proposed as potential novel therapeutic targets for treating various diseases of the central nervous system (CNS), and interestingly, few studies have reported several miRNAs that downregulate the expression levels of BDNF. However, substantial challenges exist when attempting to translate these findings into practical anti-miRNA therapeutics, especially when the targets remain inside the CNS. Thus, in this review, we summarize the specific molecular mechanisms by which several miRNAs negatively modulate the expressions of BDNF, address the potential clinical difficulties that can be faced during the development of anti-miRNA-based therapeutics and propose strategies to overcome these challenges.
authors.affiliation: Yonsei University, College of Medicine, Seoul, Korea.
authors.forename: Hwa Jeong
authors.initials: HJ
authors.lastname: You
authors.affiliation: Yonsei University, College of Medicine, Seoul, Korea.
authors.forename: Jae Hyon
authors.initials: JH
authors.lastname: Park
authors.affiliation: European University of Madrid, Madrid, Spain.|Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
authors.forename: Helios
authors.initials: H
authors.lastname: Pareja-Galeano
authors.affiliation: European University of Madrid, Madrid, Spain.|Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lucia
authors.affiliation: Department of Pediatrics, Yonsei University College of Medicine, Yonsei-Ro 50, Seodaemun-Gu, C.P.O. Box 8044, Seoul, 120-752, Korea. shinji@yuhs.ac.
authors.forename: Jae Il
authors.initials: JI
authors.lastname: Shin
mesh_terms: D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics; D015316:Genetic Therapy; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy*; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D035683:MicroRNAs
keywords: Brain-derived neurotrophic factor; MicroRNA; Therapeutic