title: Studying Kinetochore Kinases.
abstract: Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions. Describing the mechanisms and dynamics of their localized activation and deactivation is therefore instrumental for understanding the spatiotemporal control of chromosome segregation.
authors.affiliation: Division of Cancer Research, School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK. a.saurin@dundee.ac.uk.
authors.forename: Adrian T
authors.initials: AT
authors.lastname: Saurin
authors.affiliation: Hubrecht Institute - KNAW (Royal Netherlands Academy of Arts and Sciences), 3584 CT, Utrecht, The Netherlands.|Cancer Genomics Netherlands, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands.
authors.forename: Geert J P L
authors.initials: GJ
authors.lastname: Kops
mesh_terms: D004789:Enzyme Activation; D018386:Kinetochores / Q000378:metabolism*; D008938:Mitosis; D057054:Molecular Imaging / Q000379:methods; D010766:Phosphorylation; D010770:Phosphotransferases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D021381:Protein Transport; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000378:metabolism; D059008:Time-Lapse Imaging
chemical_list: D047428:Protein Kinase Inhibitors; D010770:Phosphotransferases
keywords: Antibody; Kinase; Kinetochore; Phosphorylation; Signaling; Small molecule inhibitor; Spindle checkpoint