title: Effects of theta-rhythm transcranial alternating current stimulation (4.5 Hz-tACS) in patients with clozapine-resistant negative symptoms of schizophrenia: a case series.
abstract: Our aim was to assess the efficacy and safety of theta-rhythm transcranial Alternating Current Stimulation (4.5 Hz-tACS) in patients with clozapine-resistant symptoms of schizophrenia. In an open case series, 3 patients received 20 sessions of 4.5 Hz-tACS (20 min, 2 mA) applied over the dorsolateral prefrontal cortex. The patients exhibited a decrease of negative symptoms (-10 %), general symptoms (-18 %) and an improvement of insight into the illness (-25 %). 4.5 Hz-tACS might be a suitable alternative treatment for clozapine-resistant symptoms of schizophrenia.
authors.affiliation: Résidence ENNESRINE, Cab G12, 2036, La Soukra, Tunisia.
authors.forename: Lassaad
authors.initials: L
authors.lastname: Kallel
authors.affiliation: Centre Interdisciplinaire de Recherche en Réadaptation et en Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale, Medical School, Université Laval, Québec, QC, Canada.
authors.forename: Marine
authors.initials: M
authors.lastname: Mondino
authors.affiliation: Centre Interdisciplinaire de Recherche en Réadaptation et en Intégration Sociale, Centre de Recherche de l'Institut Universitaire en Santé Mentale, Medical School, Université Laval, Québec, QC, Canada. jerome.brunelin@ch-le-vinatier.fr.|INSERM U1028, CNRS UMR5292, Lyon University, University Lyon 1, Lyon Neuroscience Research Center, PSYR2 team: Psychiatric Disorders: from Resistance to Response Team, Centre Hospitalier Le Vinatier, 69678, Bron, France. jerome.brunelin@ch-le-vinatier.fr.
authors.forename: Jerome
authors.initials: J
authors.lastname: Brunelin
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D003024:Clozapine / Q000009:adverse effects; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000628:therapy*; D013826:Theta Rhythm / Q000502:physiology*; D065908:Transcranial Direct Current Stimulation / Q000379:methods*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine
keywords: DLPFC; Insight; Prefrontal cortex; Schizophrenia; tACS; tDCS