title: Effects of Enterococcus faecalis CECT 7121 on Cryptosporidium parvum infection in mice.
abstract: Cryptosporidium is an opportunistic protozoan parasite of humans and animals worldwide and causes diarrheal disease that is typically self-limiting in immunocompetent hosts but often life threatening to immunocompromised individuals. However, there is a lack of completely efficient therapy available. Probiotics have attracted the attention as potential antiparasite compounds against protozoa involved in intestinal infections. This study investigated the effects of administration of probiotic Enterococcus faecalis CECT 7121 on Cryptosporidium parvum infection in immunosuppressed mice. Effects on C. parvum infection at the intestinal mucosa were studied and scored at each portion of the gut. It was demonstrated that Ef CECT 7121 interfered with C. parvum infection when both probiotic and parasite were present in the same intestinal location suggesting that Ef CECT 7121 supplementation can alleviate the negative effects of C. parvum infection.
authors.affiliation: Centro de Estudios Microbiológicos y Parasitológicos (CUDEMyP), Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, La Plata, 1900, Argentina. valeriadelcoco@med.unlp.edu.ar.|Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. valeriadelcoco@med.unlp.edu.ar.
authors.forename: Valeria F
authors.initials: VF
authors.lastname: Del Coco
authors.affiliation: Centro de Estudios Microbiológicos y Parasitológicos (CUDEMyP), Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, La Plata, 1900, Argentina.
authors.forename: Mónica D
authors.initials: MD
authors.lastname: Sparo
authors.affiliation: Cátedra de Patología B, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina.
authors.forename: Alicia
authors.initials: A
authors.lastname: Sidoti
authors.affiliation: Environmental Microbial and Food Safety Laboratory, Beltsville Agricultural Research Center, United States Department of Agriculture, Beltsville, MD, USA.
authors.forename: Mónica
authors.initials: M
authors.lastname: Santín
authors.affiliation: Centro de Estudios Microbiológicos y Parasitológicos (CUDEMyP), Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, La Plata, 1900, Argentina.
authors.forename: Juan Angel
authors.initials: JA
authors.lastname: Basualdo
authors.affiliation: Centro de Estudios Microbiológicos y Parasitológicos (CUDEMyP), Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, La Plata, 1900, Argentina.|Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Buenos Aires, Argentina.
authors.forename: María Alejandra
authors.initials: MA
authors.lastname: Córdoba
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage; D003457:Cryptosporidiosis / Q000188:drug therapy* / Q000469:parasitology; D016785:Cryptosporidium parvum / Q000502:physiology*; D004195:Disease Models, Animal; D013293:Enterococcus faecalis / Q000502:physiology*; D006801:Humans; D016867:Immunocompromised Host; D007413:Intestinal Mucosa / Q000382:microbiology / Q000469:parasitology; D051379:Mice; D019936:Probiotics / Q000008:administration & dosage*
chemical_list: D000977:Antiparasitic Agents
keywords: Cryptosporidium; Enterococcus faecalis CECT7121; Immunosuppressed mice; Probiotics