title: The hnRNP family: insights into their role in health and disease.
abstract: Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies.
authors.affiliation: Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Parking P4, Building V, Room 1.30, Universiteitsplein 1, 2610, Antwerp, Belgium.|Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium.
authors.forename: Thomas
authors.initials: T
authors.lastname: Geuens
authors.affiliation: Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Parking P4, Building V, Room 1.30, Universiteitsplein 1, 2610, Antwerp, Belgium.|Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium.
authors.forename: Delphine
authors.initials: D
authors.lastname: Bouhy
authors.affiliation: Peripheral Neuropathy Group, VIB Molecular Genetics Department, University of Antwerp-CDE, Parking P4, Building V, Room 1.30, Universiteitsplein 1, 2610, Antwerp, Belgium. vincent.timmerman@molgen.vib-ua.be.|Neurogenetics Laboratory, Institute Born Bunge, University of Antwerp, Antwerp, Belgium. vincent.timmerman@molgen.vib-ua.be.
authors.forename: Vincent
authors.initials: V
authors.lastname: Timmerman
mesh_terms: D017398:Alternative Splicing / Q000235:genetics; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000473:pathology; D014176:Protein Biosynthesis; D020871:RNA Stability / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D016601:RNA-Binding Proteins; D014158:Transcription, Genetic
chemical_list: D034441:Heterogeneous-Nuclear Ribonucleoproteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins