title: Integrative literature review of the reported uses of serological tests in leprosy management.
abstract: An integrative literature review was conducted to synthesize available publications regarding the potential use of serological tests in leprosy programs. We searched the databases Literatura Latino-Americana e do Caribe em Ciências da Saúde, Índice Bibliográfico Espanhol em Ciências da Saúde, Acervo da Biblioteca da Organização Pan-Americana da Saúde, Medical Literature Analysis and Retrieval System Online, Hanseníase, National Library of Medicine, Scopus, Ovid, Cinahl, and Web of Science for articles investigating the use of serological tests for antibodies against phenolic glycolipid-I (PGL-I), ML0405, ML2331, leprosy IDRI diagnostic-1 (LID-1), and natural disaccharide octyl-leprosy IDRI diagnostic-1 (NDO-LID). From an initial pool of 3.514 articles, 40 full-length articles fulfilled our inclusion criteria. Based on these papers, we concluded that these antibodies can be used to assist in diagnosing leprosy, detecting neuritis, monitoring therapeutic efficacy, and monitoring household contacts or at-risk populations in leprosy-endemic areas. Thus, available data suggest that serological tests could contribute substantially to leprosy management.
authors.affiliation: Departamento de Enfermagem Básica, Faculdade de Enfermagem, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Angélica da Conceição Oliveira Coelho
authors.initials: Ada C
authors.lastname: Fabri
authors.affiliation: Programa de Pós-graduação em Enfermagem, Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Ana Paula Mendes
authors.initials: AP
authors.lastname: Carvalho
authors.affiliation: Programa de Pós-graduação em Enfermagem, Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Nayara Figueiredo
authors.initials: NF
authors.lastname: Vieira
authors.affiliation: Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Isabela de Caux
authors.initials: Ide C
authors.lastname: Bueno
authors.affiliation: Programa de Pós-graduação em Enfermagem, Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Rayssa Nogueira
authors.initials: RN
authors.lastname: Rodrigues
authors.affiliation: Faculdade de Enfermagem, Universidade Federal de Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Thayenne Barrozo Mota
authors.initials: TB
authors.lastname: Monteiro
authors.affiliation: Programa de Pós-graduação em Enfermagem, Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Correa-Oliveira
authors.affiliation: Infectious Disease Research Institute, Seattle, WA, USA.
authors.forename: Malcolm S
authors.initials: MS
authors.lastname: Duthie
authors.affiliation: Programa de Pós-graduação em Enfermagem, Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Francisco Carlos Félix
authors.initials: FC
authors.lastname: Lana
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000097:blood*; D006017:Glycolipids / Q000097:blood*; D006801:Humans; D007918:Leprosy / Q000175:diagnosis*; D009166:Mycobacterium leprae / Q000276:immunology*; D012698:Serologic Tests / Q000379:methods*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D006017:Glycolipids; C045169:phenolic glycolipid I, Mycobacterium leprae