title: The differential frequency of Lineage(-)CRTH2(-)CD45(+)NKp44(-)CD117(-)CD127(+)ILC subset in the inflamed terminal ileum of patients with Crohn's disease.
abstract: Deregulation of various components of the immune system has been reported in the inflamed gut of Crohn's disease (CD) patients. Innate lymphoid cells (ILCs) are novel innate effector lymphocytes which can rapidly respond to danger signals, from invading pathogens or tissue damage, to maintain homeostasis, especially along the mucosal surfaces. The purpose of this study is to compare composition of the intestinal ILCs subsets of CD patients with differential inflammatory conditions of the terminal ileum, which are marked by distinct histological appearances and mucosal profiles of cytokines. We observed alterations in the frequency of Lineage(-)CRTH2(-)CD45(+)NKp44(-)CD117(-)CD127(+)ILC subset in the inflamed terminal ileum.
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, P.O. Box 100214, Gainesville, FL 32610, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, P.O. Box 100214, Gainesville, FL 32610, USA.
authors.forename: Andria L
authors.initials: AL
authors.lastname: Doty
authors.affiliation: Department of Surgery, College of Medicine, University of Florida, P.O. Box 100286, Gainesville, FL 32610, USA.
authors.forename: Atif
authors.initials: A
authors.lastname: Iqbal
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, P.O. Box 100214, Gainesville, FL 32610, USA. Electronic address: Sarah.Glover@medicine.ufl.edu.
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Glover
mesh_terms: D000328:Adult; D019070:Cell Lineage; D003424:Crohn Disease / Q000276:immunology*; D006801:Humans; D007082:Ileum / Q000473:pathology*; D007113:Immunity, Innate; D016130:Immunophenotyping; D007249:Inflammation / Q000276:immunology*; D053699:Interleukin-7 Receptor alpha Subunit / Q000378:metabolism; D007413:Intestinal Mucosa / Q000276:immunology*; D017493:Leukocyte Common Antigens / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D055629:Natural Cytotoxicity Triggering Receptor 2 / Q000378:metabolism; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism; D011982:Receptors, Prostaglandin / Q000378:metabolism
chemical_list: D053699:Interleukin-7 Receptor alpha Subunit; C112837:NCR2 protein, human; D055629:Natural Cytotoxicity Triggering Receptor 2; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; D019009:Proto-Oncogene Proteins c-kit; D017493:Leukocyte Common Antigens; C036293:prostaglandin D2 receptor
keywords: CD; ILC frequency; Terminal ileum