title: Marine Biodiscovery Goes Deeper: Using In Vivo Bioassays Based on Model Organisms to Identify Biomedically Relevant Marine Metabolites.
abstract: Secondary metabolites from marine organisms are structurally diverse small molecules with high levels of bioactivity, and represent an underutilized resource for modern drug discovery. To facilitate the identification of drug-like marine metabolites, the significant potential of in vivo models of human disease - in particular those suitable for medium-throughput screening and bioassay-guided fractionation - should be explored in future marine biodiscovery efforts. Here, we explore the advantages of Caenorhabditis elegans, Drosophila, and zebrafish bioassays for marine biodiscovery, and review recent progress in using these in vivo models to identify bioactive marine metabolites.
authors.affiliation: Chemical Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.
authors.forename: Korbin H J
authors.initials: KH
authors.lastname: West
authors.affiliation: Chemical Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Crawford
mesh_terms: D000818:Animals; D059001:Aquatic Organisms; D001681:Biological Assay / Q000379:methods; D001688:Biological Products; D017173:Caenorhabditis elegans; D004330:Drosophila; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D008954:Models, Biological; D015027:Zebrafish
chemical_list: D001688:Biological Products