title: Fabrication, characterization, and in vitro evaluation of silver-containing arabinoxylan foams as antimicrobial wound dressing.
abstract: Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam's rheological, morphological, porous, and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 h. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity necessary to be a candidate material in wound dressing development. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2456-2465, 2016.
authors.affiliation: Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia, 23284.
authors.forename: Donald C
authors.initials: DC
authors.lastname: Aduba
authors.affiliation: Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, 23298.
authors.forename: Seon-Sook
authors.initials: SS
authors.lastname: An
authors.affiliation: Department of Biomedical Engineering, University of Memphis, Memphis, Tennessee, 38152.
authors.forename: Gretchen S
authors.initials: GS
authors.lastname: Selders
authors.affiliation: Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia, 23219.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Oral Biology, Augusta University, Augusta, Georgia, 30912.
authors.forename: W
authors.initials: W
authors.lastname: Andrew Yeudall
authors.affiliation: Department of Biomedical Engineering, University of Memphis, Memphis, Tennessee, 38152.
authors.forename: Gary L
authors.initials: GL
authors.lastname: Bowlin
authors.affiliation: Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, 23298.
authors.forename: Todd
authors.initials: T
authors.lastname: Kitten
authors.affiliation: Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia, 23219.|Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, 23298.|Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, 23298.
authors.forename: Hu
authors.initials: H
authors.lastname: Yang
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000517:prevention & control; D001458:Bandages; D001672:Biocompatible Materials / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry*; D005612:Freeze Drying; D006735:Horseradish Peroxidase / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D051379:Mice; D041681:NIH 3T3 Cells; D016062:Porosity; D012834:Silver / Q000008:administration & dosage* / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*; D014990:Xylans / Q000737:chemistry*; D003313:Zea mays / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D014990:Xylans; D012834:Silver; C085118:arabinoxylan; D006861:Hydrogen Peroxide; D006735:Horseradish Peroxidase
keywords: Kirby-Bauer disk diffusion susceptibility test; arabinoxylan; polysaccharide; silver dressing; wound healing