title: OC36 - Diagnostic approach of primary cilia dyskinesia: Greek experience.
abstract: Theme: Complex health care and chronic disease management.
  
  
  BACKGROUND
  Primary Cilia Dyskinesia (PCD) is a rare, genetically heterogeneous disease that causes chronic pulmonary inflammation and progressive loss of lung function due to the dysfunction of cilia.
  
  
  OBJECTIVE
  To present the Greek experience in development and implementation of standardized operational procedures (SOP) in diagnostic testing of PCD.
  
  
  METHODS
  After special training, SOP consisting of nasal NO (nNO) measurement, high speed videomicroscopy (HVM), transmission electron microscopy (TEM) and shipment of the sample for high resolution immunofluorescence (IF) microscopy in difficult cases, were applied.
  
  
  RESULTS
  From September 2014 until December 2015 197 tests were performed to 147 suspected patients. 17 patients were finally diagnosed with PCD.
  
  
  CONCLUSIONS
  PCD is a rare disease that can be diagnosed through SOP. Early diagnosis and appropriate treatment of PCD will reduce not only the morbidity and mortality to patients, but also the burden of healthcare costs.
authors.affiliation: 3rd Dept of Paediatrics, 'Attikon' Hospital, Greece.
authors.forename: Barbara
authors.initials: B
authors.lastname: Boutopoulou
authors.affiliation: 3rd Dept of Paediatrics, 'Attikon' Hospital, Greece.
authors.forename: Marios
authors.initials: M
authors.lastname: Papadopoulos
authors.affiliation: 3rd Dept of Paediatrics, 'Attikon' Hospital, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Douros
authors.affiliation: 3rd Dept of Paediatrics, 'Attikon' Hospital, Greece.
authors.forename: Iordanis
authors.initials: I
authors.lastname: Papadopoulos
authors.affiliation: 3rd Dept of Paediatrics, 'Attikon' Hospital, Greece.
authors.forename: Basilis
authors.initials: B
authors.lastname: Grammeniatis
authors.affiliation: 3rd Dept of Paediatrics, 'Attikon' Hospital, Greece.
authors.forename: Kostas
authors.initials: K
authors.lastname: Priftis
mesh_terms: D000368:Aged; D002923:Cilia / Q000473:pathology / Q000502:physiology; D002925:Ciliary Motility Disorders / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D006115:Greece; D017408:Guidelines as Topic; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000379:methods; D018715:Microscopy, Video / Q000379:methods; D008875:Middle Aged
keywords: Diagnostic approach; primary cilia dyskinesia.