title: Canine atopic dermatitis: breed risk in Australia and evidence for a susceptible clade.
abstract: BACKGROUND
  Genetic studies on canine atopic dermatitis (CAD) indicate that large populations from one geographical location are preferred for the identification of relevant susceptibility genes. Australian dogs are relatively isolated; studies on CAD in this population are limited.
  
  
  OBJECTIVE
  To identify breeds at risk in the Australian dog population and to compare with worldwide breed predisposition.
  
  
  METHODS
  Case records (n = 23,000) from University Veterinary Teaching Hospital (UVTH) dogs, including 722 with CAD.
  
  
  METHODS
  The breed proportion of CAD and odds risk (OR) were calculated. A systematic review of 13 previous studies (1971-2010) was performed and compared to the study results by implementing an atopic dermatitis (AD)-to-reference population ratio (ADRPR).
  
  
  RESULTS
  Eleven dog breeds with significant increased OR (≥1.0) were identified; all with breed CAD cases proportionally higher than their base hospital population. Gender risk in males from the pug dog breed (P = 0.007) was detected and the bichon frise breed had a similar trend (P = 0.05). Sixteen predisposed dog breeds were identified by systematic review. All breeds with significant increased OR in UVTH had ADRPR > 1.4; five (boxer, bulldog, Labrador retriever, pug, West Highland white terrier) were recognized as predisposed worldwide. One clade of breeds with common ancestry was highly represented in CAD cases worldwide and in Australia (81% of the significant OR cases).
  
  
  CONCLUSIONS
  The use of a large population from one geographical location and ADRPR provided an objective comparison between worldwide AD studies; it identified one common clade of susceptible breeds. Breed genetics and related clinical presentation may help CAD diagnosis and treatment.
authors.affiliation: Faculty of Veterinary Science B19, The University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: Hamutal
authors.initials: H
authors.lastname: Mazrier
authors.affiliation: Faculty of Veterinary Science B19, The University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Vogelnest
authors.affiliation: Faculty of Veterinary Science B19, The University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Thomson
authors.affiliation: Faculty of Veterinary Science B19, The University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: Rosanne M
authors.initials: RM
authors.lastname: Taylor
authors.affiliation: Faculty of Veterinary Science B19, The University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Williamson
mesh_terms: D000818:Animals; D001315:Australia / Q000453:epidemiology; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D004283:Dog Diseases / Q000453:epidemiology / Q000235:genetics*; D004285:Dogs; D020022:Genetic Predisposition to Disease; D016017:Odds Ratio; D012307:Risk Factors