title: [Retinal vessel diameter variation analysis in diabetic patients].
abstract: OBJECTIVE
  To explore the influence factors of retinal vascular changes in diabetes patients.
  
  
  METHODS
  Case control study. One hundred and fifty-five type 2 diabetes patients were divided into NDR group (n=80) and DR group (n=70) according to the presence of diabetic retinopathy. Fundus photographs were taken after pupil dilated, the diameter of retinal arterioles and venules were measured between 1.0 PD and 1.5 PD. To analyze the relationship between retinal artery diameter, vein diameter and hypertension, diabetes duration, and DR stage. With retinal artery and vein diameter as the dependent variable, DR stage, hypertension, diabetes duration, insulin using time and age as independent variables, using step method, multiple linear regression was undergoing.
  
  
  RESULTS
  The diameter of retinal vein in DR group and NDR group were (90.37+7.95) and (83.45±7.80) μm, the difference was statistically significant (t=5.446, P=0.000). Retinal vein diameter was positively correlated with DR stage and diabetes duration (r=0.377, 0.250; P=0.000, 0.002). DR stage (b=2.382, P=0.000) had a linear relationship with retinal vein diameter (R(2)=0.142, F=25.285). The regression equation was: retinal vein diameter =84.269+ 2.382 · DR stage. Retinal artery diameter was negatively correlated with DR stage, diabetes duration, and hypertension duration (r=-0.453, -0.343, -0.199. P=0.000, 0.000, 0.013). DR stage (b=-2.091, P=0.000) and age (b=-0.182, P=0.000) has a linear relationship with retinal artery diameter (R(2)=0.290, F=31.088). The regression equation was: retinal artery diameter =64.011-2.091·DR stage -0.182·age.
  
  
  CONCLUSIONS
  With DR developed, retinal vein diameter increases, retinal artery diameter decreases in diabetic patients. The duration of diabetes mellitus and hypertension were not related to the diameter of retinal artery and vein.
authors.affiliation: Department of Ophthalmology, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
authors.forename: Xizhe
authors.initials: X
authors.lastname: Wang
authors.forename: Dachuan
authors.initials: D
authors.lastname: Liu
mesh_terms: D000367:Age Factors; D001160:Arterioles / Q000473:pathology; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003930:Diabetic Retinopathy / Q000209:etiology / Q000473:pathology*; D005654:Fundus Oculi; D006801:Humans; D006973:Hypertension / Q000150:complications; D012161:Retinal Artery / Q000473:pathology; D012169:Retinal Vein / Q000473:pathology; D012171:Retinal Vessels / Q000473:pathology*; D013997:Time Factors; D014699:Venules / Q000473:pathology