title: The influence of positive selection and trans-species evolution on DPB diversity in the golden snub-nosed monkeys (Rhinopithecus roxellana).
abstract: Genetic variation plays a significant role in the adaptive potential of the endangered species. The variation at major histocompatibility complex (MHC) genes can offer valuable information on selective pressure related to natural selection and environmental adaptation, particularly the ability of a host to continuously resist evolving parasites. Thus, the genetic polymorphism on exon 2 of the MHC DPB1 gene in the golden snub-nosed monkeys (Rhinopithecus roxellana) was specifically analyzed. The results show that the 6 Rhro-DPB1 alleles identified from 87 individuals exhibit positive selection and trans-species polymorphism. The results also imply that although the populations of the species have experienced dramatic reduction and severe habitat fragmentation in recent Chinese history, balancing selection still maintains relatively consistent, with moderate DPB1 polymorphism. Thus, the study provides valuable information and evidence in developing effective strategies and tactics for genetic health and population size expansion of the species. It also offers strong genetic background for further studies on other primate species, particularly those in Rhinopithecus-a further endeavor that would result in fully understanding the MHC genetic information of the Asian colobines.
authors.affiliation: Shaanxi Key Laboratory for Animal Conservation, and College of Life Sciences, Northwest University, Xi'an, 710069, China.
authors.forename: Xiaoyue
authors.initials: X
authors.lastname: Song
authors.affiliation: Shaanxi Key Laboratory for Animal Conservation, and College of Life Sciences, Northwest University, Xi'an, 710069, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Shaanxi Key Laboratory for Animal Conservation, and College of Life Sciences, Northwest University, Xi'an, 710069, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Huang
authors.affiliation: Shaanxi Key Laboratory for Animal Conservation, and College of Life Sciences, Northwest University, Xi'an, 710069, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Chen
authors.affiliation: Shaanxi Key Laboratory for Animal Conservation, and College of Life Sciences, Northwest University, Xi'an, 710069, China.
authors.forename: Songtao
authors.initials: S
authors.lastname: Guo
authors.affiliation: Shaanxi Key Laboratory for Animal Conservation, and College of Life Sciences, Northwest University, Xi'an, 710069, China.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Qi
authors.affiliation: Shaanxi Key Laboratory for Animal Conservation, and College of Life Sciences, Northwest University, Xi'an, 710069, China.
authors.forename: Gang
authors.initials: G
authors.lastname: He
authors.affiliation: Shaanxi Key Laboratory for Animal Conservation, and College of Life Sciences, Northwest University, Xi'an, 710069, China.|The School of Anatomy, Physiology and Human Biology, University of Western Australia, Perth, Australia.
authors.forename: Ruliang
authors.initials: R
authors.lastname: Pan
authors.affiliation: Shaanxi Key Laboratory for Animal Conservation, and College of Life Sciences, Northwest University, Xi'an, 710069, China. baoguoli@nwu.edu.cn.|Xi'an Branch of Chinese Academy of Sciences, Xi'an, China. baoguoli@nwu.edu.cn.
authors.forename: Baoguo
authors.initials: B
authors.lastname: Li
mesh_terms: D000818:Animals; D002681:China; D016673:Colobinae / Q000235:genetics*; D005091:Exons; D005260:Female; D059868:HLA-DP beta-Chains / Q000235:genetics*; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D010802:Phylogeny; D011110:Polymorphism, Genetic; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen
keywords: Genetic diversity; MHC; Positive selection; Rhinopithecus roxellana; Trans-species polymorphism