title: Use of computed tomography assessed kidney length to predict split renal GFR in living kidney donors.
abstract: OBJECTIVE
  Screening of living kidney donors may require scintigraphy to split glomerular filtration rate (GFR). To determine the usefulness of computed tomography (CT) to split GFR, we compared scintigraphy-split GFR to CT-split GFR. We evaluated CT-split GFR as a screening test to detect scintigraphy-split GFR lower than 40 mL/min/1.73 m2/kidney.
  
  
  METHODS
  This was a monocentric retrospective study on 346 potential living donors who had GFR measurement, renal scintigraphy, and CT. We predicted GFR for each kidney by splitting GFR using the following formula: Volume-split GFR for a given kidney = measured GFR*[volume of this kidney/(volume of this kidney + volume of the opposite kidney)]. The same formula was used for length-split GFR. We compared length- and volume-split GFR to scintigraphy-split GFR at donation and with a 4-year follow-up.
  
  
  RESULTS
  A better correlation was observed between length-split GFR and scintigraphy-split GFR (r = 0.92) than between volume-split GFR and scintigraphy-split GFR (r = 0.89). A length-split GFR threshold of 45 mL/min/1.73 m2/kidney had a sensitivity of 100 % and a specificity of 75 % to detect scintigraphy-split GFR less than 40 mL/min/1.73 m2/kidney. Both techniques with their respective thresholds detected living donors with similar eGFR evolution during follow-up.
  
  
  CONCLUSIONS
  Length-split GFR can be used to detect patients requiring scintigraphy.
  
  
  CONCLUSIONS
  • Excellent correlation between kidney length and scintigraphy predicted GFR • Kidney length screening detects all donors with GFR lower than 40 mL/min/1.73 m2• Kidney length screening can replace scintigraphy screening.
authors.affiliation: AP-HP, Hôpital Necker-Enfants Malades, Renal Transplantation Department, Paris Descartes University, Paris, France. gaillard-francois@hotmail.fr.
authors.forename: François
authors.initials: F
authors.lastname: Gaillard
authors.affiliation: Linköping University, Linköping, Sweden.
authors.forename: Patrik
authors.initials: P
authors.lastname: Pavlov
authors.affiliation: AP-HP, Hôpital Necker-Enfants Malades, Radiology Department, Paris Descartes University, Paris, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Tissier
authors.affiliation: AP-HP, Hôpital Européen Georges Pompidou, Nuclear Medicine Department, Paris Descartes University, Paris, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Harache
authors.affiliation: AP-HP, Hôpital Européen Georges Pompidou, Physiology Department, Paris Descartes University, and INSERM, Unit 970, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Eladari
authors.affiliation: AP-HP, Hôpital Européen Georges Pompidou, Urology Department, Paris Descartes University, Paris, France.
authors.forename: Marc-Olivier
authors.initials: MO
authors.lastname: Timsit
authors.affiliation: AP-HP, Hôpital Necker-Enfants Malades, Renal Transplantation Department, Paris Descartes University, Paris, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Fournier
authors.affiliation: AP-HP, Hôpital Necker-Enfants Malades, Renal Transplantation Department, Paris Descartes University, Paris, France.
authors.forename: Carine
authors.initials: C
authors.lastname: Léon
authors.affiliation: AP-HP, Hôpital Européen Georges Pompidou, Nuclear Medicine Department, Paris Descartes University, Paris, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Hignette
authors.affiliation: AP-HP, Hôpital Européen Georges Pompidou, Physiology Department, Paris Descartes University, and INSERM, Unit 1151, Paris, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Friedlander
authors.affiliation: AP-HP, Hôpital Necker-Enfants Malades, Radiology Department, Paris Descartes University, Paris, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Correas
authors.affiliation: AP-HP, Hôpital Européen Georges Pompidou, Nuclear Medicine Department, Paris Descartes University, Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Weinmann
authors.affiliation: AP-HP, Hôpital Européen Georges Pompidou, Urology Department, Paris Descartes University, Paris, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Méjean
authors.affiliation: AP-HP, Hôpital Européen Georges Pompidou, Physiology Department, Paris Descartes University, INSERM, Unit umrs1138, and CNRS Unit erl8228, Paris, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Houillier
authors.affiliation: AP-HP, Hôpital Necker-Enfants Malades, Renal Transplantation Department, Paris Descartes University, Paris, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Legendre
authors.affiliation: AP-HP, Hôpital Européen Georges Pompidou, Physiology Department, Paris Descartes University, and INSERM, Unit 1151, Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Courbebaisse
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000502:physiology*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: CT; kidney; living donor; renal transplantation; split renal function/split GFR