title: Mean Platelet Volume as an Independent Predictive Marker for Pathologic Complete Response after Neoadjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer.
abstract: BACKGROUND
  The impact of mean platelet volume (MPV) on prognosis, diagnosis and response to therapy in cancer patients has been widely investigated. In the present study, we evaluated whether MPV at diagnosis has predictive value for pathologic complete response (pCR) after neoadjuvant chemotherapy in patients with locally advanced breast cancer (LABC).
  
  
  METHODS
  A total of 109 patients with LABC from Akdeniz University and Antalya Research and Training Hospital were evaluated retrospectively.
  
  
  RESULTS
  ROC curve analysis suggested that the optimum MPV cut-off point for LABC patients with pCR (+) was 8.15 (AUC:0.378, 95%CI [0.256- 0.499], p=0.077). The patients with MPV <8.15 had higher pCR rates (29.2% vs. 13.1%, p=0.038). After binary logistic regression analysis, MPV and estrogen receptor absence were independent predictors for pCR.
  
  
  CONCLUSIONS
  MPV has an independent predictive value for pCR after neoadjuvant chemotherapy in patients with LABC.
authors.affiliation: Department of Medical Oncology, Antalya Research and Training Hospital, Antalya, Turkey E-mail : drangelkarakurt@hotmail.com.
authors.forename: Hasan
authors.initials: H
authors.lastname: Mutlu
authors.forename: Melek Karakurt
authors.initials: MK
authors.lastname: Eryılmaz
authors.forename: Fatma Yalçcn
authors.initials: FY
authors.lastname: Musri
authors.forename: Seyda
authors.initials: S
authors.lastname: Gunduz
authors.forename: Derya Kıvrak
authors.initials: DK
authors.lastname: Salim
authors.forename: Hasan Senol
authors.initials: HS
authors.lastname: Coskun
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D063847:Mean Platelet Volume; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D012372:ROC Curve; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone