title: Beneficial effects of agomelatine in experimental model of sepsis-related acute kidney injury.
abstract: BACKGROUND
  Sepsis-related acute kidney injury (AKI) is a serious complication of sepsis. Problems persist regarding early diagnosis and treatment of AKI. The aim of the present study was to evaluate the efficacy of agomelatine, which is primarily known for its positive effects on depressive and anxiety disorders in sepsis-related AKI.
  
  
  METHODS
  Sepsis model was created with cecal ligation puncture (CLP). Rats were separated into 4 groups of 8 each: the control group, the sham-operated group, the CLP+saline group, and the CLP+agomelatine group. Agomelatine was administered intraperitoneally in doses of 20 mg/kg.
  
  
  RESULTS
  In the agomelatine group, reductions were observed in levels of tumor necrosis factor α (TNF-α), malondialdehyde (MDA), blood urea nitrogen (BUN), and creatinine, as well as in histological kidney scores, compared to the non-treated group. In addition, it was demonstrated that agomelatine treatment had positive effect on sepsis-induced morphological damage to renal and tubular tissues.
  
  
  CONCLUSIONS
  Agomelatine showed strong efficacy in sepsis-related AKI, demonstrated with histological and biochemical results in an experimental model. It is believed that antioxidant and pro-inflammatory effects of agomelatine are responsible for the improvement in kidneys.
authors.affiliation: Department of Emergency Medicine, Gaziosmanpaşa University Faculty of Medicine, Tokat-Turkey. drnursahbs@hotmail.com.
authors.forename: Nurşah
authors.initials: N
authors.lastname: Başol
authors.affiliation: Department of Physiology, İstanbul Bilim University Faculty of Medicine, İstanbul-Turkey.
authors.forename: Oytun
authors.initials: O
authors.lastname: Erbaş
authors.affiliation: Department of Histology and Embryology, Ege University Faculty of Medicine, İzmir-Turkey.
authors.forename: Türker
authors.initials: T
authors.lastname: Çavuşoğlu
authors.affiliation: Department of Biochemistry, Dumlupınar University Evliya Çelebi Training and Research Hospital, Kütahya-Turkey.
authors.forename: Ayfer
authors.initials: A
authors.lastname: Meral
authors.affiliation: Department of Histology and Embryology, İstanbul Bilim University Faculty of Medicine, İstanbul-Turkey.
authors.forename: Utku
authors.initials: U
authors.lastname: Ateş
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000627:therapeutic use*; D058186:Acute Kidney Injury / Q000150:complications / Q000188:drug therapy*; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D023421:Models, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D018805:Sepsis / Q000150:complications / Q000188:drug therapy*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D003404:Creatinine; D006993:Hypnotics and Sedatives; D008315:Malondialdehyde; D014409:Tumor Necrosis Factor-alpha; C084711:agomelatine; D009281:Naphthalenes