title: High prevalence of diffuse large B-cell lymphoma in occult hepatitis B virus-infected patients in the Tohoku district in Eastern Japan.
abstract: Occult hepatitis B virus (HBV) infection is a clinical challenge, but its relationship to clinicopathologic features and the risk of progression to malignant lymphoma (ML) are poorly defined. We estimated the prevalence of HBV infection of 1,358 patients with newly diagnosed ML. HBV infection was more prevalent in ML than in control patients. The occult HBV infection group had a higher median onset age, no liver or spleen involvement, and higher prevalence of diffuse large B-cell lymphoma than the other groups, indicating that occult HBV infection is a distinct clinicopathologic entity. J. Med. Virol. 88:2206-2210, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba, Japan. tajima@nirs.go.jp.|Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology (DNHMED), Yamagata University School of Medicine, Yamagata, Japan. tajima@nirs.go.jp.
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tajima
authors.affiliation: Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Takahashi
authors.affiliation: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ishizawa
authors.affiliation: Department of Hematology/Oncology, Internal Medicine, Iwate Medical University, Morioka, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Murai
authors.affiliation: Department of Hematology, Aomori Prefectural Central Hospital, Aomori, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Akagi
authors.affiliation: Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan.
authors.forename: Hideyoshi
authors.initials: H
authors.lastname: Noji
authors.affiliation: Division of Hematology, Department of Internal Medicine, Miyagi Cancer Center, Natori, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Sasaki
authors.affiliation: Department of Hematology, Iwate Prefectural Central Hospital, Morioka, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Wano
authors.affiliation: Department of Medical Oncology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
authors.forename: Jugoh
authors.initials: J
authors.lastname: Itoh
authors.affiliation: Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology (DNHMED), Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kato
authors.affiliation: Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Scichishima
authors.affiliation: Department of Hematology/Oncology, Internal Medicine, Iwate Medical University, Morioka, Japan.
authors.forename: Yoji
authors.initials: Y
authors.lastname: Ishida
authors.affiliation: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Harigae
authors.affiliation: Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sawada
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058345:Asymptomatic Infections / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000453:epidemiology; D006510:Hepatitis B Antibodies / Q000097:blood; D006515:Hepatitis B virus / Q000302:isolation & purification; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008223:Lymphoma / Q000150:complications* / Q000453:epidemiology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D006510:Hepatitis B Antibodies
keywords: clinicopathologic features; diffuse large B-cell lymphoma; hepatitis B virus; malignant lymphoma; occult HBV infection