title: Analysis of 4931 renal biopsy data in central China from 1994 to 2014.
abstract: The purpose of this study is to investigate the changing spectrum and clinicopathologic correlation of biopsy-proven renal diseases in central China. We retrospectively analyzed data of 4931 patients who underwent renal biopsy in ten hospitals between September 1994 and December 2014. Among them, 81.55% were primary glomerular diseases (GD), and 13.02% were secondary GD. IgA nephropathy (IgAN) was the most common primary GD (43.45%), followed by focal glomerulonephritis (16.79%), mesangial proliferative glomerulonephritis (MsPGN, 14.35%), and membranous nephropathy (MN, 13.28%). IgAN was leading primary GD in patients under 60 years old, while MN was the leading one over 60 years old. The most frequent secondary GD was lupus nephritis (LN) (47.35%). The prevalence of IgAN, MN and minimal change disease was found to increase significantly (p < 0.001, p < 0.001, and p < 0.01, respectively), while that of MsPGN, membranoproliferative glomerulonephritis and LN decreased significantly (p < 0.001, p < 0.001, and p < 0.05, respectively). The main indication for renal biopsy was proteinuria and hematuria (49.03%), followed by nephrotic syndrome (NS, 20.36%). IgAN was the most common cause in patients with proteinuria and hematuria, chronic-progressive kidney injury, hematuria and acute kidney injury; and MN was the leading cause of NS. Primary GD remained the predominant renal disease in central China. IgAN and LN were the most prevalent histopathologic lesions of primary and secondary GD, respectively. The spectrum of biopsy-proven renal disease had a great change in the past two decades. Proteinuria and hematuria was the main indication for renal biopsy.
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Xiu
authors.initials: X
authors.lastname: Xu
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ning
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Shang
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Menglan
authors.initials: M
authors.lastname: Li
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ku
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Yueqiang
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Dai
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Jufang
authors.initials: J
authors.lastname: Shao
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zeng
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Min
authors.initials: M
authors.lastname: Han
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: He
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yao
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Yongman
authors.initials: Y
authors.lastname: Lv
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Xiaocheng
authors.initials: X
authors.lastname: Liu
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Shuwang
authors.initials: S
authors.lastname: Ge
authors.affiliation: a Department of Nephrology , Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D005921:Glomerulonephritis / Q000453:epidemiology* / Q000473:pathology*; D006417:Hematuria / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000453:epidemiology / Q000473:pathology; D015995:Prevalence; D011507:Proteinuria / Q000453:epidemiology / Q000473:pathology; D012189:Retrospective Studies; D055815:Young Adult
keywords: Central China; clinical manifestation; epidemiology; renal biopsy; renal disease; renal pathology