title: Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals.
abstract: Alkylglycerols (AKGs), isolated or present in shark liver oil have anti-inflammatory properties. Complement 3 (C3) and 4 (C4) participate in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity. In a randomized, controlled, crossover study, 26 non-diabetes obese individuals were assigned two preparations with low (LAC, 10 mg AKGs) and high (HAC, 20 mg AKGs) AKG content. Intervention periods were of 3 weeks preceded by 2-week washout periods in which shark liver oil was avoided. Cholesterol, C3, C4, and vascular endothelial growth factor (VEGF) decreased in a linear trend (P < 0.01) from baseline (control) to LAC and HAC. Values after HAC were significantly lower (P < 0.05) versus both baseline and after LAC. No adverse effects were observed or reported. Data from this pilot study open a promising field for the study of the beneficial effects of AKGs on cardiovascular risk factors in obese individuals.
authors.affiliation: Endocrinology Department of Hospital del Mar, Barcelona, Spain.|PhD Research Program in Dietetics and Nutrition (EEES H0502), Barcelona University, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Parri
authors.affiliation: Cardiovascular Risk and Nutrition Research Group, IMIM-Research Institut Hospital del Mar, Barcelona, Spain. mfito@imim.es.|CIBER of Physyopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain. mfito@imim.es.|Parc de Recerca Biomèdica de Barcelona, Carrer Dr. Aiguader, 88, 08003, Barcelona, Spain. mfito@imim.es.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Fitó
authors.affiliation: Departamento de Producción y Caracterización de Nuevos alimentos, Instituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, Spain.
authors.forename: C F
authors.initials: CF
authors.lastname: Torres
authors.affiliation: Cardiovascular Risk and Nutrition Research Group, IMIM-Research Institut Hospital del Mar, Barcelona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Muñoz-Aguayo
authors.affiliation: Cardiovascular Risk and Nutrition Research Group, IMIM-Research Institut Hospital del Mar, Barcelona, Spain.|CIBER of Epidemiology and Public Health, Madrid, Spain.
authors.forename: H
authors.initials: H
authors.lastname: Schröder
authors.affiliation: Endocrinology Department of Hospital del Mar, Barcelona, Spain.
authors.forename: J F
authors.initials: JF
authors.lastname: Cano
authors.affiliation: Departamento de Producción y Caracterización de Nuevos alimentos, Instituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Vázquez
authors.affiliation: Departamento de Producción y Caracterización de Nuevos alimentos, Instituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, Spain.|IMDEA-Food Institute, CEI (UAM-CSIC), Madrid, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Reglero
authors.affiliation: CIBER of Physyopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain. maria.nuproas@gmail.com.|NUPROAS Handelsbolag, Nackă, Sweden. maria.nuproas@gmail.com.|NUPROAS Handelsbolag (NUPROAS HB), Spanish Office: P.O. Box 93, Cassà de la Selva, 17224, Girona, Spain. maria.nuproas@gmail.com.
authors.forename: María-Isabel
authors.initials: MI
authors.lastname: Covas
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000302:isolation & purification; D015415:Biomarkers / Q000097:blood; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage* / Q000302:isolation & purification; D005990:Glycerol / Q000008:administration & dosage* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000175:diagnosis / Q000178:diet therapy*; D010865:Pilot Projects; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors / Q000097:blood*; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D005395:Fish Oils; D042461:Vascular Endothelial Growth Factor A; D005990:Glycerol
keywords: Alkylglycerols; Complement 3; Complement 4; Inflammation; Obesity; Vascular endothelial growth factor