title: Transcending Psychosis: The Complexity of Comorbidity in Schizophrenia.
abstract: Schizophrenic illness encompasses diverse clinical phenomena and consists of unclear underlying pathogeneses. For the past century, the comorbidities in schizophrenia have drawn persistent interest and debate due to its high prevalence rate and a need for better management. However, its clinical and biological diversity continue to challenge both the practicing clinicians and researchers. Emerging clinical and research evidence in the past decade suggest a distinct biopsychosocial pathogenesis and unique clinical attributes in some comorbid disorders in patients with schizophrenia. In addition, current evidence also supports improved outcomes with specific assessment and treatment of these subgroup of schizophrenia. The recent changes in DSV-5 and shift in the NIMH focus towards the real world clinical practice and research provide increased impetus to explore the pathogeneses and treatment of schizophrenia with comorbid disorders.
authors.affiliation: Department of Clinical Medical Science, Seoul National University, Seoul, South Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Yum
authors.affiliation: Department of Psychiatry, New York Medical College, Franklin Delano Roosevelt VA Medical Center (116), 2094 Albany Post Road, Montrose, NY 10548, USA. Electronic address: Michael.hwang@va.gov.
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Hwang
authors.affiliation: Department of Psychiatry, St Louis University, St Louis, MO 63104, USA.
authors.forename: Henry A
authors.initials: HA
authors.lastname: Nasrallah
authors.affiliation: Predoctoral Program in Clinical Psychology, Long Island University, Brookville, NY 11548, USA.
authors.forename: Lewis A
authors.initials: LA
authors.lastname: Opler
mesh_terms: D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology*; D012559:Schizophrenia / Q000453:epidemiology*
keywords: Comorbid disorder; Diagnosis; Pathogenesis; Schizophrenia; Treatment