title: Comparison of diagnostic capability of macular ganglion cell complex and retinal nerve fiber layer among primary open angle glaucoma, ocular hypertension, and normal population using Fourier-domain optical coherence tomography and determining their functional correlation in Indian population.
abstract: BACKGROUND
  Analysis of diagnostic ability of macular ganglionic cell complex and retinal nerve fiber layer (RNFL) in glaucoma.
  
  
  OBJECTIVE
  To correlate functional and structural parameters and comparing predictive value of each of the structural parameters using Fourier-domain (FD) optical coherence tomography (OCT) among primary open angle glaucoma (POAG) and ocular hypertension (OHT) versus normal population.
  
  
  METHODS
  Single centric, cross-sectional study done in 234 eyes.
  
  
  METHODS
  Patients were enrolled in three groups: POAG, ocular hypertensive and normal (40 patients in each group). After comprehensive ophthalmological examination, patients underwent standard automated perimetry and FD-OCT scan in optic nerve head and ganglion cell mode. The relationship was assessed by correlating ganglion cell complex (GCC) parameters with mean deviation. Results were compared with RNFL parameters.
  
  
  METHODS
  Data were analyzed with SPSS, analysis of variance, t-test, Pearson's coefficient, and receiver operating curve.
  
  
  RESULTS
  All parameters showed strong correlation with visual field (P < 0.001). Inferior GCC had highest area under curve (AUC) for detecting glaucoma (0.827) in POAG from normal population. However, the difference was not statistically significant (P > 0.5) when compared with other parameters. None of the parameters showed significant diagnostic capability to detect OHT from normal population. In diagnosing early glaucoma from OHT and normal population, only inferior GCC had statistically significant AUC value (0.715).
  
  
  CONCLUSIONS
  In this study, GCC and RNFL parameters showed equal predictive capability in perimetric versus normal group. In early stage, inferior GCC was the best parameter. In OHT population, single day cross-sectional imaging was not valuable.
authors.affiliation: Department of Ophthalmology, Calcutta National Medical College, Kolkata, West Bengal, India.
authors.forename: Nabanita
authors.initials: N
authors.lastname: Barua
authors.affiliation: Department of Ophthalmology, Anand Hospital and Eye Centre, Jaipur, Rajasthan, India.
authors.forename: Chitra
authors.initials: C
authors.lastname: Sitaraman
authors.affiliation: Department of Ophthalmology, Anand Hospital and Eye Centre, Jaipur, Rajasthan, India.
authors.forename: Sonu
authors.initials: S
authors.lastname: Goel
authors.affiliation: Department of Ophthalmology, Calcutta National Medical College, Kolkata, West Bengal, India.
authors.forename: Chandana
authors.initials: C
authors.lastname: Chakraborti
authors.affiliation: Department of Ophthalmology, Anand Hospital and Eye Centre, Jaipur, Rajasthan, India.
authors.forename: Sonai
authors.initials: S
authors.lastname: Mukherjee
authors.affiliation: Department of Ophthalmology, Anand Hospital and Eye Centre, Jaipur, Rajasthan, India.
authors.forename: Hemandra
authors.initials: H
authors.lastname: Parashar
mesh_terms: D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000175:diagnosis* / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology; D012372:ROC Curve; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014794:Visual Fields / Q000502:physiology*