title: [Efficacy of periprostatic nerve block anesthesia for pain control in transrectal ultrasound- guided systematic prostate biopsy].
abstract: OBJECTIVE
  To evaluate the efficacy of periprostatic nerve block anesthesia (PPNB) for pain relief in transrectal ultrasound-guided systematic prostate biopsy (PBx).
  
  
  METHODS
  We reviewed the data of patients undergoing initial PBx at our center from November, 2013 to January, 2015. Only the patients with 12-core systemic PBx were included and 111 patients were eligible for this study, among whom 52 patients received PPNB and 59 did not. PPNB was achieved by an injection of 5 mL of 1% lidocaine at the angle between the seminal vesicle and base of the prostate on each side before biopsy. The DRE pain score, probe insert pain score, and biopsy pain score were assessed by visual analogue scale (VAS) immediately after the biopsy. The complications were recorded and evaluated immediately after and at 7 days after the biopsy.
  
  
  RESULTS
  The mean age, prostate volume, total prostate specific antigen (tPSA), free PSA (fPSA), and abnormal DRE were comparable between the 2 groups (P>0.05). Immediately after the biopsy, no difference was found between the 2 groups in DRE pain score (1.40±0.98 vs 1.39±0.91, P=0.102) or probe insert pain score (2.07±0.96 vs 2.03±0.90, P=0.960), but the biopsy pain score was significantly lower in PPNB group than in no PPNB group (2.54±1.42 vs 3.07±1.43, P=0.033). The incidence of the procedure-related complications was similar between the 2 groups (P>0.05).
  
  
  CONCLUSIONS
  PPNB can significantly lower the biopsy pain score in PBx without increasing the incidence of complications.
authors.affiliation: Department of Urology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.E-mail: xieyi_1976@hotmail.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xie
authors.forename: Fang-Jian
authors.initials: FJ
authors.lastname: Zhou
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Li
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Jiang
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Wu
authors.forename: Zi-Ke
authors.initials: ZK
authors.lastname: Qin
authors.forename: Hui
authors.initials: H
authors.lastname: Han
authors.forename: Zhuo-Wei
authors.initials: ZW
authors.lastname: Liu
mesh_terms: D001706:Biopsy; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D009407:Nerve Block; D010146:Pain / Q000517:prevention & control; D059408:Pain Management / Q000379:methods*; D010147:Pain Measurement; D011467:Prostate / Q000000981:diagnostic imaging*; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis; D014463:Ultrasonography
chemical_list: D008012:Lidocaine; D017430:Prostate-Specific Antigen