title: Changes in Liver Volume in Patients with Chronic Hepatitis C Undergoing Antiviral Therapy.
abstract: OBJECTIVE
  Liver volumetric analysis has not been used to detect hepatic remodelling during antiviral therapy before. We measured liver volume (LV) changes on volumetric magnetic resonance imaging during hepatitis C antiviral therapy.
  
  
  METHODS
  22 biopsy-staged patients (median [range] age 45(19-65) years; 9F, 13M) with chronic hepatitis C virus infection were studied. LV was measured at the beginning, end of treatment and 6 months post-treatment using 3D T1-weighted acquisition, normalised to patient weight. Liver outlines were drawn manually on 4 mm thick image slices and LV calculated. Inter-observer agreement was analysed. Patients were also assessed longitudinally using biochemical parameters and liver stiffness using Fibroscan™.
  
  
  RESULTS
  Sustained viral response (SVR) was achieved in 13 patients with a mean baseline LV/kg of 0.022 (SD 0.004) L/kg. At the end of treatment, the mean LV/kg was 0.025 (SD 0.004, P = 0.024 cf baseline LV/kg) and 0.026 (SD 0.004, P = 0.008 cf baseline LV/kg) 6 months post-treatment (P = 0.030 cf baseline, P = 0.004). Body weight-corrected end of treatment LV change was significantly higher in patients with SVR compared to patients not attaining SVR (P = 0.050). End of treatment LV change was correlated to initial ALT (R (2) = 0.479, P = 0.037), but not APRI, AST, viral load or liver stiffness measurements. There was a correlation of 0.89 between observers for measured slice thickness.
  
  
  CONCLUSIONS
  LV increased during anti-viral treatment, while the body weight-corrected LV increase persisted post-antiviral therapy and was larger in patients with SVR.
authors.affiliation: Hepatology Section, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London W2 1NY, United Kingdom; Robert Steiner MRI Unit, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London W12 ONN, United Kingdom.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Fitzpatrick
authors.affiliation: Hepatology Section, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London W2 1NY, United Kingdom.
authors.forename: Jin Un
authors.initials: JU
authors.lastname: Kim
authors.affiliation: Hepatology Section, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London W2 1NY, United Kingdom.
authors.forename: Jeremy F L
authors.initials: JF
authors.lastname: Cobbold
authors.affiliation: Hepatology Section, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London W2 1NY, United Kingdom.
authors.forename: Mark J W
authors.initials: MJ
authors.lastname: McPhail
authors.affiliation: Hepatology Section, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London W2 1NY, United Kingdom.
authors.forename: Mary M E
authors.initials: MM
authors.lastname: Crossey
authors.affiliation: Hepatology Section, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London W2 1NY, United Kingdom.
authors.forename: Aluel A
authors.initials: AA
authors.lastname: Bak-Bol
authors.affiliation: Hepatology Section, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London W2 1NY, United Kingdom.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Zaky
authors.affiliation: Hepatology Section, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London W2 1NY, United Kingdom.
authors.forename: Simon D
authors.initials: SD
authors.lastname: Taylor-Robinson
keywords: ALT, Alanine aminotransferase; APRI, Aspartate transaminase to platelet ratio index; AST, Aspartate transaminase; CHC, Chronic hepatitis C; CLD, Chronic liver disease; CT, Computed tomography; EASL, European Association for the Study of the Liver; HCC, Hepatocellular carcinoma; HCV, Hepatitis C virus; LV, Liver volume; MRI, Magnetic resonance imaging; NAFLD, Non-alcoholic fatty liver disease; NI, Necroinflammatory; SVR, Sustained viral response; hepatitis C virus; liver volume; magnetic resonance imaging; sustained viral response