title: Hypoxia as pathogenic factor affecting the eye tissues: The selective apoptotic damage of the conjunctiva and anterior epithelium of the cornea.
abstract: The effect of acute hypoxia on the occurrence of apoptosis in eye cells in rats placed in a pressure chamber was studied. Selective primary lesion of cells of the conjunctiva and the anterior corneal epithelium was found. A possible role of the simulated hypoxic conditions in the dry eye syndrome pathogenesis, which is accompanied by primary lesion of cells in the anterior eye surface tissues is discussed.
authors.affiliation: Medical Center "Medkvadrat,", Moscow, Russia.
authors.forename: S I
authors.initials: SI
authors.lastname: Akberova
authors.affiliation: Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia. yuliya.mark@gmail.com.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Markitantova
authors.affiliation: Moscow Regional Clinical Research Institute (MONIKI), Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Ryabtseva
authors.affiliation: Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia.
authors.forename: O G
authors.initials: OG
authors.lastname: Stroeva
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001562:Benzimidazoles; D003228:Conjunctiva / Q000473:pathology / Q000503:physiopathology*; D003315:Cornea / Q000473:pathology / Q000503:physiopathology*; D004249:DNA Damage / Q000502:physiology; D004195:Disease Models, Animal; D015352:Dry Eye Syndromes; D005456:Fluorescent Dyes; D000860:Hypoxia / Q000473:pathology / Q000503:physiopathology*; D020287:In Situ Nick-End Labeling; D008297:Male; D008856:Microscopy, Fluorescence; D011312:Pressure; D017208:Rats, Wistar; D012640:Seizures / Q000473:pathology / Q000503:physiopathology
chemical_list: D001562:Benzimidazoles; D005456:Fluorescent Dyes; C017807:bisbenzimide ethoxide trihydrochloride