title: Metagenomics, Metatranscriptomics, and Metabolomics Approaches for Microbiome Analysis.
abstract: Microbiomes are ubiquitous and are found in the ocean, the soil, and in/on other living organisms. Changes in the microbiome can impact the health of the environmental niche in which they reside. In order to learn more about these communities, different approaches based on data from multiple omics have been pursued. Metagenomics produces a taxonomical profile of the sample, metatranscriptomics helps us to obtain a functional profile, and metabolomics completes the picture by determining which byproducts are being released into the environment. Although each approach provides valuable information separately, we show that, when combined, they paint a more comprehensive picture. We conclude with a review of network-based approaches as applied to integrative studies, which we believe holds the key to in-depth understanding of microbiomes.
authors.affiliation: Bioinformatics Research Group (BioRG), School of Computing and Information Sciences, Florida International University, Miami, FL, USA.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Aguiar-Pulido
authors.affiliation: Bioinformatics Research Group (BioRG), School of Computing and Information Sciences, Florida International University, Miami, FL, USA.
authors.forename: Wenrui
authors.initials: W
authors.lastname: Huang
authors.affiliation: Chromatin Structure and Evolution Group (Chromevol), Department of Biological Sciences, Florida International University, Miami, FL, USA.
authors.forename: Victoria
authors.initials: V
authors.lastname: Suarez-Ulloa
authors.affiliation: Bioinformatics Research Group (BioRG), School of Computing and Information Sciences, Florida International University, Miami, FL, USA.; Department of Computer Science, Eckerd College, St. Petersburg, FL, USA.
authors.forename: Trevor
authors.initials: T
authors.lastname: Cickovski
authors.affiliation: Biomolecular Sciences Institute, Florida International University, Miami, FL, USA.; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.; Global Health Consortium, Florida International University, Miami, FL, USA.
authors.forename: Kalai
authors.initials: K
authors.lastname: Mathee
authors.affiliation: Bioinformatics Research Group (BioRG), School of Computing and Information Sciences, Florida International University, Miami, FL, USA.; Biomolecular Sciences Institute, Florida International University, Miami, FL, USA.
authors.forename: Giri
authors.initials: G
authors.lastname: Narasimhan
keywords: metabolomics; metagenomics; metatranscriptomics; microbiome; networks