title: Manipulation of the Host Cell Cytoskeleton by Chlamydia.
abstract: Chlamydiae are obligate intracellular pathogens. They undergo a biphasic developmental cycle differentiating between the infectious but metabolically quiescent elementary body and the vegetative, but non-infectious reticulate body. Chlamydia spends a significant portion of its development in the non-infectious stage, demanding an effective strategy of manipulating the host cells to ensure its intracellular survival and replication. A common target of all Chlamydia species studied so far is the host cell cytoskeleton, with past and recent findings revealing crucial roles in invasion, inclusion maintenance, nutrient acquisition, and egress. The molecular details of how Chlamydia co-opts the cytoskeleton is becoming clearer, with bacterial factors and their corresponding host cell targets identified.
authors.affiliation: School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
authors.forename: Ana T
authors.initials: AT
authors.lastname: Nogueira
authors.affiliation: School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA.
authors.forename: Antonio T
authors.initials: AT
authors.lastname: Pedrosa
authors.affiliation: School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA. rcarabeo@vetmed.wsu.edu.
authors.forename: Rey A
authors.initials: RA
authors.lastname: Carabeo
mesh_terms: D000818:Animals; D002689:Chlamydia / Q000472:pathogenicity*; D003599:Cytoskeleton / Q000378:metabolism* / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans