title: Meta-Analysis of the Association Between Whole and Refined Grain Consumption and Stroke Risk Based on Prospective Cohort Studies.
abstract: The association between whole and refined grain consumption and stroke risk remains unclear. A search using MEDLINE and EMBASE databases was performed through February 29, 2016. Seven prospective studies with a total of 446 451 subjects and 5892 stroke events were included. The summary relative risk (SRR) of stroke for the high versus low consumption was 0.95 (95% confidence interval [CI] = 0.83-1.14) for total grains, 0.92 (95% CI = 0.72-1.17) for whole grains, and 0.99 (95% CI = 0.84-1.16) for refined grains. Diets rich in whole grains were inversely associated with ischemic stroke risk (SRR = 0.75, 95% CI = 0.60-0.95). Our meta-analysis revealed that whole and refined grain consumption is not associated with total stroke risk; however, whole grain consumption is associated with reduced ischemic stroke risk.
authors.affiliation: 1 The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.|2 The Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Chen
authors.affiliation: 2 The Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Huang
authors.affiliation: 2 The Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.affiliation: 2 The Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.affiliation: 2 The Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: 1 The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Lan
mesh_terms: D004032:Diet; D002523:Edible Grain; D006801:Humans; D011446:Prospective Studies; D012306:Risk; D020521:Stroke / Q000453:epidemiology*
keywords: meta-analysis; refined grains; relative risk; stroke; whole grains