title: The therapeutic voyage of pyrazole and its analogs: A review.
abstract: Pyrazole, a five membered heteroaromatic ring with two nitrogen atoms is of immense significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic categories viz. antianxiety, anti-inflammatory, antipsychotic, anticancer, antiobesity, analgesic, antipyretic etc. has made it an indispensable anchor for design and development of new pharmacological agents. Owing to the development of novel and new pyrazole based therapeutic agents at a faster pace, there is a need to couple the latest information with previously available information to understand status of this moiety in medicinal chemistry research. The review herein highlights the therapeutic worth of pyrazole derivatives. Several therapeutically active pyrazole based derivatives developed by numerous scientists across the globe are reported here.
authors.affiliation: Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, 110062, India.
authors.forename: Mohemmed Faraz
authors.initials: MF
authors.lastname: Khan
authors.affiliation: Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, 110062, India.
authors.forename: Mohammad Mumtaz
authors.initials: MM
authors.lastname: Alam
authors.affiliation: Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, 110062, India.
authors.forename: Garima
authors.initials: G
authors.lastname: Verma
authors.affiliation: Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, 110062, India.
authors.forename: Wasim
authors.initials: W
authors.lastname: Akhtar
authors.affiliation: Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, 110062, India.
authors.forename: Mymoona
authors.initials: M
authors.lastname: Akhter
authors.affiliation: Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, 110062, India. Electronic address: shaqiq@gmail.com.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shaquiquzzaman
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D011720:Pyrazoles / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D011720:Pyrazoles
keywords: Analgesic; Anti-inflammatory; Anticancer; Antimicrobial; Antiviral; Heterocyclic; Pharmacological activity; Pyrazole