title: MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis.
abstract: The process of metabolic re-programing is linked to the activation of oncogenes and/or suppression of tumour suppressor genes, which are regulated by microRNAs (miRNAs). The interplay between oncogenic transformation-driven metabolic re-programming and modulation of aberrant miRNAs further established their critical role in the initiation, promotion and progression of cancer by creating a tumorigenesis-prone microenvironment, thus orchestrating processes of evasion to apoptosis, angiogenesis and invasion/migration, as well metastasis. Given the involvement of miRNAs in tumour development and their global deregulation, they may be perceived as biomarkers in cancer of therapeutic relevance.
authors.affiliation: Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona 60020, Italy. m.tomasetti@univpm.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Tomasetti
authors.affiliation: Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona 60020, Italy. m.amati@univpm.it.
authors.forename: Monica
authors.initials: M
authors.lastname: Amati
authors.affiliation: Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona 60020, Italy. l.santarelli@univpm.it.
authors.forename: Lory
authors.initials: L
authors.lastname: Santarelli
authors.affiliation: Mitochondria, Apoptosis and Cancer Research Group, School of Medical Science and Menzies Health Institute Queensland, Griffith University, Southport, QLD 4222, Australia. j.neuzil@griffith.edu.au.|Molecular Therapy Group, Institute of Biotechnology, Czech Academy of Sciences, Prague-West 25243, Czech Republic. j.neuzil@griffith.edu.au.
authors.forename: Jiri
authors.initials: J
authors.lastname: Neuzil
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D063646:Carcinogenesis / Q000235:genetics* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053858:Metabolic Networks and Pathways; D035683:MicroRNAs / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; D015513:Oncogene Proteins
keywords: metabolic reprogramming; miR-126 and cancer-stroma environment; miRNA regulating signaling pathways; miRNAs; tumorigenesis