title: Magnetic nanotherapeutics for dysregulated synaptic plasticity during neuroAIDS and drug abuse.
abstract: The human immunodeficiency virus (HIV) is a neurotropic virus. It induces neurotoxicity and subsequent brain pathologies in different brain cells. Addiction to recreational drugs remarkably affects the initiation of HIV infections and expedites the progression of acquired immunodeficiency syndrome (AIDS) associated neuropathogenesis. Symptoms of HIV-associated neurocognitive disorders (HAND) are noticed in many AIDS patients. At least 50 % of HIV diagnosed cases show one or other kind of neuropathological signs or symptoms during different stages of disease progression. In the same line, mild to severe neurological alterations are seen in at least 80 % autopsies of AIDS patients. Neurological illnesses weaken the connections between neurons causing significant altercations in synaptic plasticity. Synaptic plasticity alterations during HIV infection and recreational drug abuse are mediated by complex cellular phenomena involving changes in gene expression and subsequent loss of dendritic and spine morphology and physiology. New treatment strategies with ability to deliver drugs across blood-brain barrier (BBB) are being intensively investigated. In this context, magnetic nanoparticles (MNPs) based nanoformulations have shown significant potential for target specificity, drug delivery, drug release, and bioavailability of desired amount of drugs in non-invasive brain targeting. MNPs-based potential therapies to promote neuronal plasticity during HIV infection and recreational drug abuse are being developed.
authors.affiliation: Department of Immunology, Center for Personalized Nanomedicine/Institute of NeuroImmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.
authors.forename: Vidya
authors.initials: V
authors.lastname: Sagar
authors.affiliation: Department of Immunology, Center for Personalized Nanomedicine/Institute of NeuroImmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.
authors.forename: Venkata Subba Rao
authors.initials: VS
authors.lastname: Atluri
authors.affiliation: Department of Immunology, Center for Personalized Nanomedicine/Institute of NeuroImmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.
authors.forename: Sudheesh
authors.initials: S
authors.lastname: Pilakka-Kanthikeel
authors.affiliation: Department of Immunology, Center for Personalized Nanomedicine/Institute of NeuroImmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA. nairm@fiu.edu.
authors.forename: Madhavan
authors.initials: M
authors.lastname: Nair
mesh_terms: D015526:AIDS Dementia Complex / Q000503:physiopathology* / Q000628:therapy*; D000818:Animals; D065546:Drug Liberation; D006801:Humans; D058185:Magnetite Nanoparticles / Q000627:therapeutic use*; D009473:Neuronal Plasticity; D019966:Substance-Related Disorders / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D058185:Magnetite Nanoparticles
keywords: BDNF; Bath salt; Blood-brain barrier; Cocaine; HDAC2; HIV/AIDS; Magnetic nanoparticles; Methamphetamine; Morphine; Neuropathogenesis; Nicotine; Synaptic plasticity