title: [Anesthetic Management with Propofol Alone in a Patient with Hereditary Sensory and Autonomic Neuropathy].
abstract: Hereditary sensory and autonomic neuropathy (HSAN) is a rare peripheral nerve disorder associated with sensory dysfunction (pain, touch, and pressure) and various degrees of autonomic dysfunction. We administered general anesthesia for a 54-year-old woman with HSAN type II undergoing amputation of the left hallux. She had reduced sensation for pain, pressure, and temperature since birth and frequently injured her hands and legs. Before the operation, she did not report pain in the hallux. Only propofol was given for anesthesia without use of analgesia. Intraoperatively, her vital signs were stable. To evaluate the sympathetic nervous response to surgical stimulation, we measured the plasma catecholamine levels before tracheal intubation and just before and during surgery. Plasma catecholamine levels were normal at all time points, indicating no sympathetic responses to surgical stimulation. This case suggests that anesthesia for HSAN II patients can be safely managed with propofol alone.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Fujita
authors.forename: Ai
authors.initials: A
authors.lastname: Nakamoto
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Inoue
authors.forename: Yasue
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Motoko
authors.initials: M
authors.lastname: Shimizu
authors.forename: Arisa
authors.initials: A
authors.lastname: Hotta
authors.forename: Noriko
authors.initials: N
authors.lastname: Yoshikawa
authors.forename: Naoko
authors.initials: N
authors.lastname: Ohira
authors.forename: Shigeki
authors.initials: S
authors.lastname: Tatekawa
mesh_terms: D000758:Anesthesia / Q000379:methods*; D002395:Catecholamines / Q000097:blood; D005260:Female; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology*
chemical_list: D002395:Catecholamines; D015742:Propofol