title: Lack of Benefit of Early Intervention with Dietary Flax and Fish Oil and Soy Protein in Orthologous Rodent Models of Human Hereditary Polycystic Kidney Disease.
abstract: Rationale for dietary advice in polycystic kidney disease (PKD) is based in part on animal studies that have examined non-orthologous models with progressive development of cystic disease. Since no model completely mimics human PKD, the purpose of the current studies was to examine the effects of dietary soy protein (compared to casein) or oils enriched in omega-3 fatty acids (fish or flax oil compared to soy oil) on early disease progression in two orthologous models of PKD. The models studied were Pkd2WS25/- mice as a model of autosomal dominant PKD, and PCK rats as a model of autosomal recessive PKD. After 13 weeks of feeding, dietary fish (but not flax) oil resulted in larger kidneys and greater kidney water content in female Pkd2WS25/- compared to control mice. After 12 weeks of feeding male PCK compared to control rats, both fish and flax compared to soy oil resulted in enlarged kidneys and livers, greater kidney water content and higher kidney cyst area in diseased rats. Dietary soy protein compared to casein had no effects in Pkd2WS25/- compared to control mice. In PCK rats, kidney and liver histology were not improved, but lower proteinuria and higher urine pH suggest that soy protein could be beneficial in the long term. Therefore, in contrast to studies in non-orthologous models during the progressive development phase, these studies in orthologous PKD models do not support dietary advice to increase soy protein or oils enriched in omega-3 oils in early PKD.
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada.|Canadian Centre for Agri-Food Research in Health and Medicine, St Boniface Hospital Research Centre, Winnipeg, MB, Canada.|Department of Clinical Nutrition, Suzuka University of Medical Science, Suzuka, Mie, Japan.
authors.forename: Tamio
authors.initials: T
authors.lastname: Yamaguchi
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada.|Canadian Centre for Agri-Food Research in Health and Medicine, St Boniface Hospital Research Centre, Winnipeg, MB, Canada.
authors.forename: Jessay G
authors.initials: JG
authors.lastname: Devassy
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada.|Canadian Centre for Agri-Food Research in Health and Medicine, St Boniface Hospital Research Centre, Winnipeg, MB, Canada.
authors.forename: Md
authors.initials: M
authors.lastname: Monirujjaman
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada.|Canadian Centre for Agri-Food Research in Health and Medicine, St Boniface Hospital Research Centre, Winnipeg, MB, Canada.
authors.forename: Melissa
authors.initials: M
authors.lastname: Gabbs
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada.|Canadian Centre for Agri-Food Research in Health and Medicine, St Boniface Hospital Research Centre, Winnipeg, MB, Canada.|Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.
authors.forename: Harold M
authors.identifier: 0000-0002-6982-7239
authors.initials: HM
authors.lastname: Aukema
mesh_terms: D000818:Animals; D002364:Caseins / Q000008:administration & dosage* / Q000494:pharmacology; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000494:pharmacology; D004195:Disease Models, Animal; D061345:Early Medical Intervention; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology; D019597:Flax; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009154:Mutation; D009929:Organ Size / Q000187:drug effects; D007690:Polycystic Kidney Diseases / Q000178:diet therapy* / Q000235:genetics / Q000473:pathology; D051381:Rats; D050396:TRPP Cation Channels / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D002364:Caseins; D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D050396:TRPP Cation Channels