title: Association between selenium levels and oesophageal adenocarcinoma risk: evidence from a meta-analysis.
abstract: Quantification of the association between selenium and risk of oesophageal adenocarcinoma (OAC) is still conflicting. The purpose of this meta-analysis is to explore the relationship between selenium levels and OAC risk. PubMed and Web of Knowledge were searched for the related articles. Pooled relative risks (RRs) with 95% confidence intervals (CIs) from random effects models were calculated. Sensitivity analysis and publication bias were conducted. Dose-response relationship was assessed by restricted cubic spline and variance-weighted least squares regression analysis. Five articles involving 748 OAC cases were included in this meta-analysis. Pooled results suggest that higher selenium level was not significantly associated with the risk of OAC (summary RRs=1.08, 95% CIs=0.84-1.39, I(2)=0%). Besides, no significant association was found in case-control studies (summary RRs=1.13, 95% CIs=0.84-1.52, I(2)=0%) or cohort studies (summary RRs=0.99, 95% CIs=0.55-1.78, I(2)=32.6%). A linear dose-response relationship was attested that an increase in dietary selenium intake of 10 μg/day is marginally associated with 1% increase in the risk of developing OAC (summary RRs=1.01, 95% CIs=0.99-1.03), but not statistically significant. No publication bias was found. In conclusion, our analysis indicated that a higher selenium level was not significantly associated with the risk of OAC. The relevant further studies are warranted.
authors.affiliation: Department of Thoracic Surgery, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Hong
authors.affiliation: Department of Ultrasound, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Thoracic Surgery, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Mao
authors.affiliation: Department of Thoracic Surgery, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xiong
authors.affiliation: Department of Thoracic Surgery, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of CT, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China liangbhu@163.com yingdududu@yeah.net).
authors.forename: Liangbo
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Ultrasound, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China liangbhu@163.com yingdududu@yeah.net).
authors.forename: Ying
authors.initials: Y
authors.lastname: Du
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000378:metabolism*; D000368:Aged; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000209:etiology* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012643:Selenium / Q000378:metabolism*
chemical_list: D012643:Selenium
keywords: meta-analysis; oesophageal adenocarcinoma; selenium