title: Megalencephaly-capillary malformation polymicrogyria: A review and complex pediatric case report.
abstract: Megalencephaly-Capillary Malformation Polymicrogyria (M-CAP) is a rare genetic disorder characterized by a spectrum of anomalies including macrocephaly and neurovascular malformations. Although developmental delays have been identified, research is devoid of neuropsychological data. This case report presents the neuropsychological profile of a 7-year-old, identified with M-CAP. Neuropsychological evaluation was completed subsequent to medical diagnosis. Reports from both parents and teachers included cognitive regression; specifically in the recall of learned material, reading, and information sequencing. Direct testing revealed a WISC-IV GAI at <1stpercentile, a diverse range of scores across the battery, and a splinter skill strength of average to above on visual memory tests. Performance included below grade level reading and writing, reduced adaptive functioning, and reported executive dysfunction. Her strong visual memory skills were recommended as a medium to enhance learning. Neurocognitive deficits revealed diverse, multisystem and multifocal impairments. The neuropsychological evaluation also showed significant decline from the previous evaluation and prompted a neurologic consult and corrective surgical procedure.
authors.affiliation: a Department of Neurology , Virginia Commonwealth University , Richmond , Virginia , USA.
authors.forename: Ashlee R
authors.initials: AR
authors.lastname: Loughan
authors.affiliation: b Department of Psychology , University of South Carolina , Aiken , South Carolina , USA.
authors.forename: Murphy
authors.initials: M
authors.lastname: Harrell
authors.affiliation: c TIRR Memorial Hermann , Houston , Texas , USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Perna
authors.affiliation: b Department of Psychology , University of South Carolina , Aiken , South Carolina , USA.
authors.forename: Aislyn
authors.initials: A
authors.lastname: Allen
authors.affiliation: d Department of Radiology , Virginia Commonwealth University , Richmond , Virginia , USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Suddarth
mesh_terms: D000015:Abnormalities, Multiple / Q000523:psychology*; D001288:Attention / Q000502:physiology; D002648:Child; D005260:Female; D020786:Hemangioma, Cavernous, Central Nervous System / Q000523:psychology*; D006801:Humans; D058627:Megalencephaly / Q000523:psychology*; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D065706:Polymicrogyria / Q000523:psychology*; D011932:Reading; D017445:Skin Diseases, Vascular / Q000523:psychology*; D013684:Telangiectasis / Q000151:congenital* / Q000523:psychology; D014888:Wechsler Scales
keywords: Cognitive functioning; M-CAP; Megalencephaly; genetic