title: Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation.
abstract: Neuroplastin cell recognition molecules have been implicated in synaptic plasticity. Polymorphisms in the regulatory region of the human neuroplastin gene (NPTN) are correlated with cortical thickness and intellectual abilities in adolescents and in individuals with schizophrenia.
  
  
  
  We characterized behavioral and functional changes in inducible conditional neuroplastin-deficient mice.
  
  
  
  We demonstrate that neuroplastins are required for associative learning in conditioning paradigms, e.g., two-way active avoidance and fear conditioning. Retrograde amnesia of learned associative memories is elicited by inducible neuron-specific ablation of Nptn gene expression in adult mice, which shows that neuroplastins are indispensable for the availability of previously acquired associative memories. Using single-photon emission computed tomography imaging in awake mice, we identified brain structures activated during memory recall. Constitutive neuroplastin deficiency or Nptn gene ablation in adult mice causes substantial electrophysiologic deficits such as reduced long-term potentiation. In addition, neuroplastin-deficient mice reveal profound physiologic and behavioral deficits, some of which are related to depression and schizophrenia, which illustrate neuroplastin's essential functions.
  
  
  
  Neuroplastins are essential for learning and memory. Retrograde amnesia after an associative learning task can be induced by ablation of the neuroplastin gene. The inducible neuroplastin-deficient mouse model provides a new and unique means to analyze the molecular and cellular mechanisms underlying retrograde amnesia and memory.
authors.affiliation: Neurogenetics Special Laboratory, Leibniz Institute for Neurobiology, Magdeburg, Germany.
authors.forename: Soumee
authors.initials: S
authors.lastname: Bhattacharya
authors.affiliation: Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany; Special Laboratory Electron and Laserscanning Microscopy, Leibniz Institute for Neurobiology, Magdeburg, Germany.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Herrera-Molina
authors.affiliation: Laboratory of Biological Psychology, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Victor
authors.initials: V
authors.lastname: Sabanov
authors.affiliation: Laboratory of Biological Psychology, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Tariq
authors.initials: T
authors.lastname: Ahmed
authors.affiliation: Laboratory of Biological Psychology, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Emilia
authors.initials: E
authors.lastname: Iscru
authors.affiliation: Research Group Neuropharmacology, Leibniz Institute for Neurobiology, Magdeburg, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Stöber
authors.affiliation: Institute for Biochemistry and Cell Biology, Otto-von-Guericke University, Magdeburg, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Richter
authors.affiliation: Institute for Biochemistry and Cell Biology, Otto-von-Guericke University, Magdeburg, Germany.
authors.forename: Klaus-Dieter
authors.initials: KD
authors.lastname: Fischer
authors.affiliation: Special Laboratory Noninvasive Brain Imaging, Leibniz Institute for Neurobiology, Magdeburg, Germany; Helmholtz Center for Neurodegenerative Diseases, Magdeburg, Germany; Center for Behavioral Neurosciences and Medical Faculty, Otto von Guericke University, Magdeburg, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Angenstein
authors.affiliation: Department Systems Physiology, Leibniz Institute for Neurobiology, Magdeburg, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Goldschmidt
authors.affiliation: Special Laboratory for Molecular Biology Techniques, Leibniz Institute for Neurobiology, Magdeburg, Germany; School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, United Kingdom.
authors.forename: Philip W
authors.initials: PW
authors.lastname: Beesley
authors.affiliation: Affliation link is not provided.
authors.forename: Detlef
authors.initials: D
authors.lastname: Balschun
authors.affiliation: Special Laboratory for Molecular Biology Techniques, Leibniz Institute for Neurobiology, Magdeburg, Germany; Center for Behavioral Neurosciences and Medical Faculty, Otto von Guericke University, Magdeburg, Germany.
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Smalla
authors.affiliation: Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany; Helmholtz Center for Neurodegenerative Diseases, Magdeburg, Germany; Center for Behavioral Neurosciences and Medical Faculty, Otto von Guericke University, Magdeburg, Germany.
authors.forename: Eckart D
authors.initials: ED
authors.lastname: Gundelfinger
authors.affiliation: Neurogenetics Special Laboratory, Leibniz Institute for Neurobiology, Magdeburg, Germany. Electronic address: montag@lin-magdeburg.de.
authors.forename: Dirk
authors.initials: D
authors.lastname: Montag
mesh_terms: D000648:Amnesia, Retrograde / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D001245:Association Learning / Q000502:physiology*; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials; D005239:Fear / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout
chemical_list: D008562:Membrane Glycoproteins; C577174:neuroplastin protein, mouse
keywords: Associative memory; Knockout mouse model; Learning impairment; Neuroplastin; Retrograde amnesia; Synaptic plasticity