title: Effects of different recruitment maneuvers on bacterial translocation and ventilator- induced lung injury.
abstract: BACKGROUND
  Investigated in the present study were the effects of various recruitment maneuvers (RMs) using the same inflation pressure-time product on bacterial translocation from lung to blood, and ventilator-induced lung injury (VILI).
  
  
  METHODS
  Tracheotomy was performed on anesthetized rats, and ventilation was initiated using pressure-controlled mode. Subsequently, Pseudomonas aeruginosa was inoculated through the tracheotomy tube and ventilated for 30 minutes before rats were randomly separated into 4 groups. Group 1 underwent sustained inflation (SI), Group 2 underwent low-pressure SI, Group 3 underwent modified sigh, and Group 4 was a control group. Blood cultures were taken at baseline, 15 minutes after randomization (after each RM for the first hour), and finally at 75 minutes after the last RM. The rats were euthanized and the lungs were extirpated. The left lung was taken for measurement of wet:dry weight ratio, and the right lung was used for pathologic evaluation.
  
  
  RESULTS
  Positive blood cultures were found to be higher in Group 3 at early study periods. Total pathological scores were also higher in Group 3.
  
  
  CONCLUSIONS
  Higher severity of ventilator-induced lung injury occurred in the modified sigh group, evidenced by bacterial translocation and results of histopathological evaluation.
authors.affiliation: Department of Anesthesiology, İstanbul University İstanbul Faculty of Medicine, İstanbul-Turkey.
authors.forename: Perihan
authors.initials: P
authors.lastname: Ergin Özcan
authors.affiliation: Department of Anesthesiology, İstanbul University İstanbul Faculty of Medicine, İstanbul-Turkey.
authors.forename: Özkan İbrahim
authors.initials: Öİ
authors.lastname: Akıncı
authors.affiliation: Department of Anesthesiology, İstanbul University İstanbul Faculty of Medicine, İstanbul-Turkey.
authors.forename: İpek
authors.initials: İ
authors.lastname: Edipoğlu
authors.affiliation: Department of Anesthesiology, İstanbul University İstanbul Faculty of Medicine, İstanbul-Turkey.
authors.forename: Evren
authors.initials: E
authors.lastname: Şentürk
authors.affiliation: Department of Anesthesiology, İstanbul University İstanbul Faculty of Medicine, İstanbul-Turkey.
authors.forename: Sevil
authors.initials: S
authors.lastname: Baylan
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, İstanbul University İstanbul Faculty of Medicine, İstanbul-Turkey.
authors.forename: Atahan Arif
authors.initials: AA
authors.lastname: Cağatay
authors.affiliation: Department of Pathology, Marmara University Faculty of Medicine, İstanbul-Turkey.
authors.forename: Kemal H
authors.initials: KH
authors.lastname: Türköz
authors.affiliation: Department of Anesthesiology, İstanbul University İstanbul Faculty of Medicine, İstanbul-Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Esen
authors.affiliation: Department of Anesthesiology, İstanbul University İstanbul Faculty of Medicine, İstanbul-Turkey.
authors.forename: Lütfi
authors.initials: L
authors.lastname: Telci
authors.affiliation: Department of Anesthesiology, İstanbul University İstanbul Faculty of Medicine, İstanbul-Turkey.
authors.forename: Nahit
authors.initials: N
authors.lastname: Çakar
mesh_terms: D000818:Animals; D018988:Bacterial Translocation; D008297:Male; D023421:Models, Animal; D011175:Positive-Pressure Respiration / Q000009:adverse effects; D011550:Pseudomonas aeruginosa / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D055397:Ventilator-Induced Lung Injury / Q000517:prevention & control*