title: Methotrexate treatment for ectopic pregnancy after assisted reproductive technology: A case-control study.
abstract: OBJECTIVE
  Ectopic pregnancy (EP) occurs in 2% to 5.6% of pregnancies achieved by assisted reproductive technology (ART). EP treatment options include medical treatment by uses of methotrexate (MTX) systemic injection. The objective of this study was to compare MTX treatment effectiveness for EP occurring spontaneously or following ART.
  
  
  METHODS
  A case-control study performed in the department of obstetrics and gynecology at a tertiary health care center in France. Twenty EP achieved by ART (ART group) and 60 spontaneous EP (SEP group) received MTX treatment between January 2002 and May 2012. The main outcome measures were MTX treatment failure rates, number of MTX injections administered and recovery time.
  
  
  RESULTS
  MTX treatment failure rates observed in ART and SEP groups were similar (3/20 [15%] versus 10/60 [17%]: OR=0.88 [0.22-3.58]). Mean duration of recovery time in patients with successful MTX treatment did not differ between ART and SEP groups (33±14 days versus 28±13 days, P=0.39). A second MTX injection was required more frequently in ART group than in SEP group (10/20 [50%] versus 10/60 [17%]: OR=5 [1.65-15.15]).
  
  
  CONCLUSIONS
  It is concluded that MTX treatment is equally effective for spontaneous EP and EP achieved by ART, two injections of MTX being more frequently required in case of ART.
authors.affiliation: Service de gynécologie-obstétrique, hôpital de La Conception, 147, boulevard Baille, 13005 Marseille, France.
authors.forename: A
authors.initials: A
authors.lastname: Ohannessian
authors.affiliation: Service de gynécologie-obstétrique, hôpital de La Conception, 147, boulevard Baille, 13005 Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Crochet
authors.affiliation: Service de gynécologie-obstétrique, hôpital de La Conception, 147, boulevard Baille, 13005 Marseille, France.
authors.forename: B
authors.initials: B
authors.lastname: Courbiere
authors.affiliation: Service de gynécologie-obstétrique, hôpital de La Conception, 147, boulevard Baille, 13005 Marseille, France.
authors.forename: A
authors.initials: A
authors.lastname: Gnisci
authors.affiliation: Service de gynécologie-obstétrique, hôpital de La Conception, 147, boulevard Baille, 13005 Marseille, France. Electronic address: aubert.agostini@ap-hm.fr.
authors.forename: A
authors.initials: A
authors.lastname: Agostini
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005602:France; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000188:drug therapy*; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects*; D017211:Treatment Failure
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D008727:Methotrexate
keywords: Assistance médicale à la procréation; Assisted reproductive technology; Ectopic pregnancy; Fécondation in vitro; Grossesse extra-utérine; In vitro fertilization; Methotrexate