title: THE EFFECT OF MONOSIALOGANGLYOSIDE (GM-1) ADMINISTRATION IN SPINAL CORD INJURY.
abstract: OBJECTIVE
  To evaluate the effect of monosialoganglioside (GM-1) in spinal cord trauma patients seen in our service who have not been treated with methylprednisolone.
  
  
  METHODS
  Thirty patients with acute spinal cord trauma were randomly divided into two groups. In Group 1, patients received 200 mg GM-1 in the initial assessment and thereafter received 100 mg intravenous per day for 30 days and Group 2 (control) received saline. Patients were evaluated periodically (at 6 weeks, 6 months, one year and two years), using a standardized neurological assessment of the American Spinal Injury Association / International Spinal Cord Society.
  
  
  RESULTS
  The comparative statistical analysis of motor indices, sensitive indices for pain and touch according to the standardization of ASIA / ISCOS showed that the assessments at 6 weeks, 6 months and 2 years, GM-Group 1 patients had higher rates than the control group regarding sensitivity to pain and touch, with no statistically significant difference from the motor index.
  
  
  CONCLUSIONS
  The functional assessment showed improvement in the sensitive indices of patients treated with GM1 after post-traumatic spinal cord injury compared to patients who received placebo. Level of Evidence IV, Prospective Case Studies Series.
authors.affiliation: . Universidade de São Paulo, Faculdade de Medicina, Department of Orthopedics and Traumatology, São Paulo, SP, Brazil.
authors.forename: Tarcísio Eloy Pessoa
authors.initials: TE
authors.lastname: Barros
authors.affiliation: . Universidade de São Paulo, Faculdade de Medicina, Department of Orthopedics and Traumatology, São Paulo, SP, Brazil.
authors.forename: Fernando Flores De
authors.initials: FF
authors.lastname: Araujo
authors.affiliation: . Universidade de São Paulo, Faculdade de Medicina, Department of Orthopedics and Traumatology, São Paulo, SP, Brazil.
authors.forename: Lucas Da Paz
authors.initials: Lda P
authors.lastname: Higino
authors.affiliation: . Universidade de São Paulo, Faculdade de Medicina, Department of Orthopedics and Traumatology, São Paulo, SP, Brazil.
authors.forename: Raphael Martus
authors.initials: RM
authors.lastname: Marcon
authors.affiliation: . Universidade de São Paulo, Faculdade de Medicina, Department of Orthopedics and Traumatology, São Paulo, SP, Brazil.
authors.forename: Alexandre Fogaça
authors.initials: AF
authors.lastname: Cristante
keywords: G(M1) Ganglioside; Outcome assessment (Health care).; Spinal cord injuries