title: e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease.
abstract: Today a large number of studies are focused on clarifying the complexity and diversity of the pathogenetic mechanisms inducing Parkinson disease. We used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin that induces Parkinson disease, to evaluate the change of midbrain structure and the behavior of the anti-inflammatory factor e-cadherin, interleukin-6, tyrosine hydroxylase, phosphatase and tensin homolog, and caveolin-1. The results showed a strong expression of e-cadherin, variation of length and thickness of the heavy neurofilaments, increase of interleukin-6, and reduction of tyrosine hydroxylase known to be expression of dopamine cell loss, reduction of phosphatase and tensin homolog described to impair responses to dopamine, and reduction of caveolin-1 known to be expression of epithelial-mesenchymal transition and fibrosis. The possibility that the overexpression of the e-cadherin might be implicated in the anti-inflammatory reaction to MPTP treatment by influencing the behavior of the other analyzed molecules is discussed.
authors.affiliation: Department of Pharmaceutical Science, University of Perugia, 06100 Perugia, Italy.
authors.forename: Samuela
authors.initials: S
authors.lastname: Cataldi
authors.affiliation: Department of Pharmaceutical Science, University of Perugia, 06100 Perugia, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Codini
authors.affiliation: Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle ÉPINIÈRE, ICM, 75013 Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Hunot
authors.affiliation: Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle ÉPINIÈRE, ICM, 75013 Paris, France.
authors.forename: François-Pierre
authors.initials: FP
authors.lastname: Légeron
authors.affiliation: Institute of Pathologic Anatomy and Histology, University of Perugia, 06100 Perugia, Italy.
authors.forename: Ivana
authors.initials: I
authors.lastname: Ferri
authors.affiliation: Institute of Pathologic Anatomy and Histology, University of Perugia, 06100 Perugia, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Siccu
authors.affiliation: Institute of Pathologic Anatomy and Histology, University of Perugia, 06100 Perugia, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Sidoni
authors.affiliation: Department of Clinical and Biological Sciences, University of Udine, 33100 Udine, Italy.
authors.forename: Francesco Saverio
authors.initials: FS
authors.lastname: Ambesi-Impiombato
authors.affiliation: Department of Pharmaceutical Science, University of Perugia, 06100 Perugia, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Beccari
authors.affiliation: Department of Clinical and Biological Sciences, University of Udine, 33100 Udine, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Curcio
authors.affiliation: Department of Pharmaceutical Science, University of Perugia, 06100 Perugia, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Albi
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D008810:Mice, Inbred C57BL; D010300:Parkinson Disease / Q000209:etiology* / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D015820:Cadherins; D015850:Interleukin-6; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D014446:Tyrosine 3-Monooxygenase