title: Involvement of myeloperoxidase gene polymorphism 463G>A in development of cervical squamous cell carcinoma.
abstract: BACKGROUND
  The myeloperoxidase (MPO) -463G&gt;A (rs2333227) polymorphism has been linked with increased susceptibility to the development of various malignancies. However, the data on the association of the MPO -463G&gt;A transition with cervical cancer remain inconsistent.
  
  
  METHODS
  Using high resolution melting analysis we genotyped this polymorphism in women with cervical squamous cell carcinoma (SCC) (n = 476) and controls (n = 493) from a Polish Caucasian population. Logistic regression analysis was used to adjust for the effect of confounders such as age, parity, oral contraceptive use, tobacco smoking, and menopausal status, and revealed that the MPO -463G&gt;A single nucleotide polymorphism (SNP) was associated with an increased risk of SCC.
  
  
  RESULTS
  The adjusted odds ratio (OR) for patients with the A/A genotype versus G/G genotype was 0.718 (95% CI 0.531-0.972, p = 0.0316). Stratified analyses between the MPO -463G&gt;A polymorphism and SCC risks demonstrated a protective role of the MPO -463G&gt;A SNP in patients with a positive history of parity and negative history of tobacco smoking. In patients with a positive history of parity, the age-adjusted OR for the A/A versus G/G genotype was 0.667 (95% CI 0.479-0.929, p = 0.0164). The age-adjusted OR for patients with a negative history of tobacco smoking for the A/A versus G/G genotype was 0.491 (95% CI 0.313-0.770, p = 0.0019).
  
  
  CONCLUSIONS
  Our study demonstrated that the MPO -463G&gt;A SNP may protect from SCC in women from Polish Caucasian populations.
authors.affiliation: Department of Radiotherapy and Gynecological Oncology, Greater Poland Cancer Center, Poznań - Poland.|Department of Electroradiology, Poznań University of Medical Sciences, Poznań - Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Roszak
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, Poznań - Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Lutkowska
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, Poznań - Poland.
authors.forename: Margarita
authors.initials: M
authors.lastname: Lianeri
authors.affiliation: Department of Computer Science and Statistics, Poznań University of Medical Sciences, Poznań - Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Sowińska
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, Poznań - Poland.
authors.forename: Paweł P
authors.initials: PP
authors.lastname: Jagodziński
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006801:Humans; D008875:Middle Aged; D009195:Peroxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D002583:Uterine Cervical Neoplasms / Q000201:enzymology / Q000235:genetics*
chemical_list: D009195:Peroxidase