title: TheGRIN2BandGRIN2AGene Variants Are Associated With Continuous Performance Test Variables in ADHD.
abstract: Objective:To examine the association between variants of N-methyl-D-aspartate (NMDA) receptor subunit-encoding genes (GRIN2AandGRIN2B) and continuous performance test (CPT) variables in ADHD and healthy controls.Method:In all, 253 ADHD patients and 98 controls were recruited. The diagnosis, genotype, and diagnosis-genotype interaction effects for the CPT variables were examined.Results:Significant diagnosis effects were detected for all CPT variables. There were significant genotype and interaction effects on response time variability (RTV) by theGRIN2Bvariant. The C/C subgroup had higher RTV than the C/T + T/T subgroup in ADHD, but not in controls. There were significant genotype effects on omission errors by theGRIN2Avariant. The G/G subgroup had more omission errors than the G/A + A/A subgroup in ADHD patients, but not in controls.Conclusion:These results suggest that the genetic variants ofGRIN2BandGRIN2Aconfer an increased susceptibility to attentional impairment in ADHD patients.
authors.affiliation: Seoul National University College of Medicine, Chongno-gu, Republic of Korea.
authors.forename: Johanna Inhyang
authors.initials: JI
authors.lastname: Kim
authors.affiliation: Seoul National University College of Medicine, Chongno-gu, Republic of Korea.
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Kim
authors.affiliation: National Center for Mental Health, Kwangjin-ju, Republic of Korea.
authors.forename: Subin
authors.initials: S
authors.lastname: Park
authors.affiliation: Seoul National University College of Medicine, Chongno-gu, Republic of Korea.
authors.forename: Soon-Beom
authors.initials: SB
authors.lastname: Hong
authors.affiliation: Seoul National University College of Medicine, Chongno-gu, Republic of Korea.
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Lee
authors.affiliation: Seoul National University College of Medicine, Chongno-gu, Republic of Korea.
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Paek
authors.affiliation: Chung Ang University, Dongjak-gu, Seoul, Republic of Korea.
authors.forename: Doug Hyun
authors.initials: DH
authors.lastname: Han
authors.affiliation: Sahmyook University, Nowon-gu, Seoul, Republic of Korea.
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Cheong
authors.affiliation: Seoul National University College of Medicine, Chongno-gu, Republic of Korea.
authors.forename: Bung-Nyun
authors.initials: BN
authors.lastname: Kim
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D005838:Genotype; D006801:Humans; D011930:Reaction Time; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; C121001:NR2B NMDA receptor
keywords: attention-deficit/hyperactivity disorder; genetics; neurocognitive measures