title: Synthesis and Characterization of Novel Cu(II), Pd(II) and Pt(II) Complexes with 8-Ethyl-2-hydroxytricyclo(7.3.1.0(2,7))tridecan-13-one-thiosemicarbazone: Antimicrobial and in Vitro Antiproliferative Activity.
abstract: New Cu(II), Pd(II) and Pt(II) complexes, (Cu(L)(H₂O)₂(OAc)) (1), (Cu(HL)(H₂O)₂(SO₄)) (2), (Cu(L)(H₂O)₂(NO₃)) (3), (Cu(L)(H₂O)₂(ClO₄)) (4), (Cu(L)₂(H₂O)₂) (5), (Pd(L)(OAc))H₂O (6), and (Pt(L)₂) (7) were synthesized from 8-ethyl-2-hydroxytricyclo(7.3.1.0(2,7))tridecan-13-one thiosemicarbazone (HL). The ligand and its metal complexes were characterized by IR, ¹H-NMR, (13)C-NMR, UV-Vis, FAB, EPR, mass spectroscopy, elemental and thermal analysis, magnetic susceptibility measurements and molar electric conductivity. The free ligand and the metal complexes have been tested for their antimicrobial activity against E. coli, S. enteritidis, S. aureus, E. faecalis, C. albicans and cytotoxicity against the NCI-H1573 lung adenocarcinoma, SKBR-3 human breast, MCF-7 human breast, A375 human melanoma and HL-60 human promyelocytic leukemia cell lines. Copper complex 2 exhibited the best antiproliferative activities against MCF-7 human breast cancer cells. A significant inhibition of malignant HL-60 cell growth was observed for copper complex 2, palladium complex 6 and platinum complex 7, with IC50 values of 1.6 µM, 6.5 µM and 6.4 µM, respectively.
authors.affiliation: Inorganic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", 6 Traian Vuia Street, Bucharest 020956, Romania. elenaandmihaela@yahoo.com.
authors.forename: Elena
authors.initials: E
authors.lastname: Pahonțu
authors.affiliation: Organic Chemistry Department, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Street, Bucharest 050663, Romania. c.paraschivescu@gmail.com.
authors.forename: Codruța
authors.initials: C
authors.lastname: Paraschivescu
authors.affiliation: Organic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", 6 Traian Vuia Street, Bucharest 020956, Romania. ilies_diana@hotmail.com.
authors.forename: Diana-Carolina
authors.initials: DC
authors.lastname: Ilieș
authors.affiliation: Oncology and Molecular Endocrinology Research Center CHUL, Research Center and Universite Laval, CHUQ-CHUL, 2705 Boulevard Laurier, Quebec City, QC G1V 4G2, Canada. donald.poirier@crchul.ulaval.ca.
authors.forename: Donald
authors.initials: D
authors.lastname: Poirier
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy "Victor Babeş", Timişoara 300041, Romania. camelia.sass5@gmail.com.
authors.forename: Camelia
authors.initials: C
authors.lastname: Oprean
authors.affiliation: Functional Sciences Department, Faculty of Medicine, University of Medicine and Pharmacy "Victor Babeş", 2 Eftimie Murgu Square, Timişoara 300041, Romania. genostem@yahoo.com.
authors.forename: Virgil
authors.initials: V
authors.lastname: Păunescu
authors.affiliation: Coordination Chemistry Department, Moldova State University, 60 Mateevici Street, Chisinau 2009, Moldova. dociu1946@yahoo.com.
authors.forename: Aurelian
authors.initials: A
authors.lastname: Gulea
authors.affiliation: Inorganic Chemistry Department, Faculty of Chemistry, University of Bucharest, 23 Dumbrava Rosie Street, Bucharest 020462, Romania. t_rosu0101@yahoo.com.
authors.forename: Tudor
authors.initials: T
authors.lastname: Roșu
authors.affiliation: Clinic of Urology, Universitary Emergency Central Military Hospital, Clinical Departament 3, University of Medicine and Pharmacy "Carol Davila", 6 Traian Vuia Street, Bucharest 020956, Romania. ovi78doc@yahoo.com.
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Bratu
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects*; D056831:Coordination Complexes / Q000008:administration & dosage* / Q000737:chemistry; D003300:Copper / Q000008:administration & dosage / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects / Q000472:pathogenicity; D018922:HL-60 Cells; D006801:Humans; D007239:Infections / Q000188:drug therapy* / Q000382:microbiology; D061986:MCF-7 Cells; D009369:Neoplasms / Q000188:drug therapy*; D010165:Palladium / Q000008:administration & dosage / Q000737:chemistry; D010984:Platinum / Q000008:administration & dosage / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects / Q000472:pathogenicity
chemical_list: D056831:Coordination Complexes; D010984:Platinum; D010165:Palladium; D003300:Copper
keywords: A375 human melanoma cells; HL-60 leukemia cells; MCF-7; NCI-H1573 lung adenocarcinoma cells; SKBR-3 human breast cancer cells; antimicrobial activity; copper(II); palladium(II) and platinum(II) complexes