title: Donor lymphocyte infusion after allogeneic stem cell transplantation.
abstract: Allogeneic stem cell transplantation (allo-SCT) is considered the cornerstone in the treatment of several malignant and not malignant hematological diseases. However, relapse of hematological disease after allo-SCT is considered the most challenging point in the field. The risk can be reduced through optimal patients, donor and disease selection before allo-SCT, but harnessing donor immune system is an appealing way to treat or avoid disease relapse. Donor lymphocyte infusion (DLI) is a simple and effective therapy after allo-SCT. In this paper, the efficacy of DLI will be analyzed in different hematological diseases, focusing also on their therapeutic or pre-emptive use.
authors.affiliation: Programma Trapianto Humanitas Cancer Center, Istituto Clinico Humanitas, Rozzano, Italy. Electronic address: luca.castagna@humanitas.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Castagna
authors.affiliation: Programma Trapianto Humanitas Cancer Center, Istituto Clinico Humanitas, Rozzano, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Sarina
authors.affiliation: Programma Trapianto Humanitas Cancer Center, Istituto Clinico Humanitas, Rozzano, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Bramanti
authors.affiliation: ASST-Monza, Ospedale San Gerardo, Apheresis Unit, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Perseghin
authors.affiliation: Programma Trapianto Humanitas Cancer Center, Istituto Clinico Humanitas, Rozzano, Italy.
authors.forename: Jacopo
authors.initials: J
authors.lastname: Mariotti
authors.affiliation: Programma Trapianto Humanitas Cancer Center, Istituto Clinico Humanitas, Rozzano, Italy.
authors.forename: Lucio
authors.initials: L
authors.lastname: Morabito
mesh_terms: D064591:Allografts; D001782:Blood Donors; D046148:Donor Selection / Q000379:methods*; D006402:Hematologic Diseases / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D017710:Lymphocyte Transfusion / Q000379:methods*
keywords: Allogeneic transplantation; DLI; Hematological disease; Pre-emeptive; Relapse