title: Prenatal Exposure to Perfluorinated Compounds Affects Birth Weight Through GSTM1 Polymorphism.
abstract: The aim of this study was to investigate the effect of genetic polymorphisms on the association of prenatal exposure to perfluorinated compounds (PFCs) with birth weight.
  
  
  
  We analyzed the level of eight PFCs in cord blood and two genetic polymorphisms in maternal blood of 268 subjects.
  
  
  
  Concentrations of perfluorooctanoic acid, perfluorooctane sulfonate, perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) showed significant association with a decrease in birth weight (P < 0.05). In mothers with glutathione S-transferase M1 (GSTM1) null genotype, concentrations of PFNA, PFDA, and PFUnDA showed significantly negative association with birth weight (P < 0.05).
  
  
  
  Our findings indicated that GSTM1 polymorphism might affect the association between exposure to PFCs and birth weight, suggesting the effect of genetic susceptibility on the relationship between prenatal PFCs exposure and birth outcomes.
authors.affiliation: Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, South Korea (Ms Kwon, Drs Kim, Kulkarni, Park, Ha); Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, South Korea (Dr Park); Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, South Korea (Ms Kwon, Dr Kim); Department of Health, Environment & Safety, Eulji University, Seongnam, South Korea (Dr Kho); Cancer Policy Branch (Dr Kim), National Cancer Center, Goyang, South Korea; and Chicago Medical School (Mr Shin), Rosalind Franklin University of Medicine and Science, Lake County, Illinois.
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Kwon
authors.forename: Joon Soo
authors.initials: JS
authors.lastname: Shin
authors.forename: Byung Mi
authors.initials: BM
authors.lastname: Kim
authors.forename: Surabhi
authors.initials: S
authors.lastname: Shah-Kulkarni
authors.forename: Hyesook
authors.initials: H
authors.lastname: Park
authors.forename: Young Lim
authors.initials: YL
authors.lastname: Kho
authors.forename: Eun Ae
authors.initials: EA
authors.lastname: Park
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Kim
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Ha
mesh_terms: D001724:Birth Weight; D002210:Caprylates / Q000009:adverse effects*; D003652:Decanoic Acids / Q000009:adverse effects*; D005227:Fatty Acids / Q000009:adverse effects; D005260:Female; D005466:Fluorocarbons / Q000009:adverse effects*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000235:genetics*; D056910:Republic of Korea
chemical_list: D002210:Caprylates; D003652:Decanoic Acids; D005227:Fatty Acids; D005466:Fluorocarbons; D005982:Glutathione Transferase; C586085:perfluoroundecanoic acid; C036567:perfluorodecanoic acid; C023036:perfluorooctanoic acid