title: [Chemotherapy and Anticancer Immune Responses].
abstract: Chemotherapeutic agents are widely used for cancer treatment. However, conventional and maximum-tolerated dose chemotherapy is often associated with the risk of immune deterioration via the induction and recruitment of immunosuppressive cells. Therefore, certain chemotherapeutic agents with immunostimulatory effects, including the induction of immunogenic cancer cell death and inhibition of immunosuppressive cells, must be useful. The combination of chemotherapy and immunotherapy is a promising new modality for the treatment of cancer patients. In this manuscript, I outline the in vivo induction of antitumor T cell immunity after chemotherapy and its underlying mechanisms and introduce immunogenic chemotherapy and several combinations of chemotherapy and immunotherapy.
authors.affiliation: Dept. of Immunology, Shimane University Faculty of Medicine.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Harada
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000970:Antineoplastic Agents