title: The JAK inhibitor ruxolitinib impairs dendritic cell migration via off-target inhibition of ROCK.
authors.affiliation: Medical Clinic 3, Oncology, Hematology, Immunoncology and Rheumatology, University Clinic Bonn (UKB), Bonn, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Rudolph
authors.affiliation: Medical Clinic 3, Oncology, Hematology, Immunoncology and Rheumatology, University Clinic Bonn (UKB), Bonn, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Heine
authors.affiliation: Molecular Immunology & Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Quast
authors.affiliation: Molecular Immunology & Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Kolanus
authors.affiliation: Department of Internal Medicine I, University Hospital of Bonn, Bonn, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Trebicka
authors.affiliation: Medical Clinic 3, Oncology, Hematology, Immunoncology and Rheumatology, University Clinic Bonn (UKB), Bonn, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Brossart
authors.affiliation: Medical Clinic 3, Oncology, Hematology, Immunoncology and Rheumatology, University Clinic Bonn (UKB), Bonn, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Wolf
mesh_terms: D002465:Cell Movement / Q000187:drug effects*; D003713:Dendritic Cells / Q000473:pathology*; D006801:Humans; D009570:Nitriles; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D011743:Pyrimidines; D054460:rho-Associated Kinases / Q000037:antagonists & inhibitors*
chemical_list: D009570:Nitriles; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011743:Pyrimidines; C540383:ruxolitinib; D054460:rho-Associated Kinases