title: Intensity modulated radiation therapy with simultaneous integrated boost based dose escalation on neoadjuvant chemoradiation therapy for locally advanced distal esophageal adenocarcinoma.
abstract: OBJECTIVE
  To evaluate impact of radiation therapy dose escalation through intensity modulated radiation therapy with simultaneous integrated boost (IMRT-SIB).
  
  
  METHODS
  We retrospectively reviewed the patients who underwent four-dimensional-based IMRT-SIB-based neoadjuvant chemoradiation protocol. During the concurrent chemoradiation therapy, radiation therapy was through IMRT-SIB delivered in 28 consecutive daily fractions with total radiation doses of 56 Gy to tumor and 5040 Gy dose-painted to clinical tumor volume, with a regimen at the discretion of the treating medical oncologist. This was followed by surgical tumor resection. We analyzed pathological completion response (pCR) rates its relationship with overall survival and event-free survival.
  
  
  RESULTS
  Seventeen patients underwent dose escalation with the IMRT-SIB protocol between 2007 and 2014 and their records were available for analysis. Among the IMRT-SIB-treated patients, the toxicity appeared mild, the most common side effects were grade 1-3 esophagitis (46%) and pneumonitis (11.7%). There were no cardiac events. The Ro resection rate was 94% (n = 16), the pCR rate was 47% (n = 8), and the postoperative morbidity was zero. There was one mediastinal failure found, one patient had local failure at the anastomosis site, and the majority of failures were distant in the lung or bone. The 3-year disease-free survival and overall survival rates were 41% (n = 7) and 53% (n = 9), respectively.
  
  
  CONCLUSIONS
  The dose escalation through IMRT-SIB in the chemoradiation regimen seems responsible for down-staging the distal esophageal with well-tolerated complications.
authors.affiliation: Ming Zeng, Fernando N Aguila, Taral Patel, Mark Knapp, Xue-Qiang Zhu, Xi-Lin Chen, Phillip D Price, Department of Radiation Oncology, Mount Carmel Health System, Columbus, OH 43219, United States.
authors.forename: Ming
authors.initials: M
authors.lastname: Zeng
authors.affiliation: Ming Zeng, Fernando N Aguila, Taral Patel, Mark Knapp, Xue-Qiang Zhu, Xi-Lin Chen, Phillip D Price, Department of Radiation Oncology, Mount Carmel Health System, Columbus, OH 43219, United States.
authors.forename: Fernando N
authors.initials: FN
authors.lastname: Aguila
authors.affiliation: Ming Zeng, Fernando N Aguila, Taral Patel, Mark Knapp, Xue-Qiang Zhu, Xi-Lin Chen, Phillip D Price, Department of Radiation Oncology, Mount Carmel Health System, Columbus, OH 43219, United States.
authors.forename: Taral
authors.initials: T
authors.lastname: Patel
authors.affiliation: Ming Zeng, Fernando N Aguila, Taral Patel, Mark Knapp, Xue-Qiang Zhu, Xi-Lin Chen, Phillip D Price, Department of Radiation Oncology, Mount Carmel Health System, Columbus, OH 43219, United States.
authors.forename: Mark
authors.initials: M
authors.lastname: Knapp
authors.affiliation: Ming Zeng, Fernando N Aguila, Taral Patel, Mark Knapp, Xue-Qiang Zhu, Xi-Lin Chen, Phillip D Price, Department of Radiation Oncology, Mount Carmel Health System, Columbus, OH 43219, United States.
authors.forename: Xue-Qiang
authors.initials: XQ
authors.lastname: Zhu
authors.affiliation: Ming Zeng, Fernando N Aguila, Taral Patel, Mark Knapp, Xue-Qiang Zhu, Xi-Lin Chen, Phillip D Price, Department of Radiation Oncology, Mount Carmel Health System, Columbus, OH 43219, United States.
authors.forename: Xi-Lin
authors.initials: XL
authors.lastname: Chen
authors.affiliation: Ming Zeng, Fernando N Aguila, Taral Patel, Mark Knapp, Xue-Qiang Zhu, Xi-Lin Chen, Phillip D Price, Department of Radiation Oncology, Mount Carmel Health System, Columbus, OH 43219, United States.
authors.forename: Phillip D
authors.initials: PD
authors.lastname: Price
keywords: Dose escalation; Esophageal adenocarcinoma; Intensity modulated radiation therapy; Neoadjuvant chemoradiation; Resection rate; Simultaneous integrated boost