title: Aspartame intake is associated with greater glucose intolerance in individuals with obesity.
abstract: This study examined whether sucrose, fructose, aspartame, and saccharin influences the association between obesity and glucose tolerance in 2856 adults from the NHANES III survey. Aspartame intake significantly influenced the association between body mass index (BMI) and glucose tolerance (interaction: P = 0.004), wherein only those reporting aspartame intake had a steeper positive association between BMI and glucose tolerance than those reporting no aspartame intake. Therefore, consumption of aspartame is associated with greater obesity-related impairments in glucose tolerance.
authors.affiliation: School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3, Canada.|School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3, Canada.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Kuk
authors.affiliation: School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3, Canada.|School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3, Canada.
authors.forename: Ruth E
authors.initials: RE
authors.lastname: Brown
mesh_terms: D000328:Adult; D000368:Aged; D001218:Aspartame / Q000008:administration & dosage / Q000009:adverse effects*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D002149:Energy Intake; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects; D018149:Glucose Intolerance / Q000503:physiopathology*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D064306:Non-Nutritive Sweeteners / Q000008:administration & dosage / Q000009:adverse effects*; D009749:Nutrition Surveys; D009765:Obesity / Q000503:physiopathology*; D012439:Saccharin / Q000008:administration & dosage / Q000009:adverse effects; D013395:Sucrose / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D001786:Blood Glucose; D064306:Non-Nutritive Sweeteners; D005632:Fructose; D013395:Sucrose; D012439:Saccharin; D001218:Aspartame
keywords: NHANES; National Health and Nutrition Examination Survey (NHANES); body mass index; epidemiology; indice de masse corporelle; épidémiologie