title: The Protective Effect of Baicalin Against Lead-Induced Renal Oxidative Damage in Mice.
abstract: Lead (Pb) exposure is a global environmental problem that can deplete body antioxidant enzymes, causing damage to various macromolecules and ultimately cell death. Pb exposure could lead to serious renal damage. Baicalin, a traditional Chinese medicine, could protect against renal injury through inhibition of oxidative stress and apoptosis. This study was designed to investigate the protective efficacy of baicalin against Pb-induced nephrotoxicity in mice and to elucidate the potential mechanisms using animal experiment. The results revealed that baicalin decreased Pb-induced bodyweight loss, declined kidney coefficients, and ameliorated renal function and structure in a dose-dependent manner. Meanwhile, baicalin dose dependently increased Pb-induced activity of SOD and GSH-Px, while the content of MDA in the kidney was decreased. In addition, baicalin enhanced the Bcl-2/Bax ratio associated with apoptosis in the kidney. These data indicated that further investigation of the use of baicalin as a new natural chemopreventive agent against Pd poisoning is warranted.
authors.affiliation: College of Veterinary Medicine, Jilin University, Changchun, 130062, People's Republic of China.
authors.forename: Zecai
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, Jilin University, Changchun, 130062, People's Republic of China.
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Gao
authors.affiliation: College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, People's Republic of China.
authors.forename: Mengyao
authors.initials: M
authors.lastname: Guo
authors.affiliation: College of Veterinary Medicine, Jilin University, Changchun, 130062, People's Republic of China.
authors.forename: Haichao
authors.initials: H
authors.lastname: Jiang
authors.affiliation: College of Veterinary Medicine, Jilin University, Changchun, 130062, People's Republic of China. ygcao82@jlu.edu.cn.
authors.forename: Yongguo
authors.initials: Y
authors.lastname: Cao
authors.affiliation: College of Veterinary Medicine, Jilin University, Changchun, 130062, People's Republic of China. zhangns@jlu.edu.cn.
authors.forename: Naisheng
authors.initials: N
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D007854:Lead / Q000633:toxicity*; D008297:Male; D051379:Mice; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D005419:Flavonoids; D007854:Lead; C038044:baicalin
keywords: Apoptosis; Baicalin; Kidney; Lead; Oxidative stress