title: Cooperative organocatalysis of Mukaiyama-type aldol reactions by thioureas and nitro compounds.
abstract: A unique organocatalytic system for Mukaiyama-type aldol reactions based on the cooperative action of nitro compounds and thioureas has been identified. This system is compatible with a wide range of substrates and does not require low temperatures, inert atmospheres, or an aqueous workup. A catalytic mechanism based on nitro group-mediated silyl cation transfer has been proposed.
authors.affiliation: KAUST Catalysis Center and Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia. valentin.rodionov@kaust.edu.sa.
authors.forename: Konstantin V
authors.initials: KV
authors.lastname: Bukhryakov
authors.forename: Victor G
authors.initials: VG
authors.lastname: Desyatkin
authors.forename: Valentin O
authors.initials: VO
authors.lastname: Rodionov