title: Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice.
abstract: This study aimed to investigate the therapeutic effects of Angelica sinensis polysaccharide (ASP), an active component derived from a water extract of Angelica sinensis, in high-fat diet (HFD)-fed BALB/c mice. The potential mechanisms underlying the activity of this compound were also considered. Specifically, serum and hepatic biochemical parameters were evaluated, and key proteins involved in the lipid/glucose metabolism were analyzed. Long-term feeding with a HFD induced severe fatty liver and hyperglycemia. Histological examination clearly showed that ASP reduced lipid accumulation in the liver and attenuated hepatic steatosis in HFD-fed mice. In addition, ASP markedly alleviated serum and liver lipid disorders and fatty liver via the upregulation of PPARγ expression and the activation of adiponectin-SIRT1-AMPK signaling. Furthermore, ASP also significantly relieved severe oxidative stress, demonstrating that ASP might attenuate nonalcoholic fatty liver disease via a "two-hit" mechanism. In addition, ASP reduced blood glucose levels and ameliorated insulin resistance via the regulation of related metabolic enzymes and by activating the PI3K/Akt pathway in HFD-fed mice. Our findings revealed that ASP might be used as an alternative dietary supplement or health care product to ameliorate metabolic syndrome in populations that consistently consume HFDs.
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College of Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Kaiping
authors.initials: K
authors.lastname: Wang
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College of Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Cao
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College of Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Hanxiang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College of Huazhong University of Science and Technology, 430030, Wuhan, China.
authors.forename: Zhuohong
authors.initials: Z
authors.lastname: Tang
authors.affiliation: Department of Pharmacy, Renmin Hospital of Wuhan University, No. 99, Zhangzhidong Road, 430060, Wuhan, China.
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.affiliation: Union Hospital of Huazhong University of Science and Technology, Department of Pharmacy, No. 1227, Jiefang Road, 430030, Wuhan, China.
authors.forename: Jinglin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Union Hospital of Huazhong University of Science and Technology, Department of Pharmacy, No. 1227, Jiefang Road, 430030, Wuhan, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D029971:Angelica sinensis / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D059305:Diet, High-Fat; D050171:Dyslipidemias / Q000188:drug therapy; D005234:Fatty Liver / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D005765:Gastrointestinal Agents / Q000008:administration & dosage* / Q000302:isolation & purification; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis; D008099:Liver / Q000473:pathology; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification; D011134:Polysaccharides / Q000008:administration & dosage* / Q000302:isolation & purification; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D005765:Gastrointestinal Agents; D010936:Plant Extracts; D011134:Polysaccharides; D005947:Glucose