title: Prediction of medial tibiofemoral compartment joint space loss progression using volumetric cartilage measurements: Data from the FNIH OA biomarkers consortium.
abstract: OBJECTIVE
  Investigating the association between baseline cartilage volume measurements (and initial 24th month volume loss) with medial compartment Joint-Space-Loss (JSL) progression (>0.7 mm) during 24-48th months of study.
  
  
  METHODS
  Case and control cohorts (Biomarkers Consortium subset from the Osteoarthritis Initiative (OAI)) were defined as participants with (n=297) and without (n=303) medial JSL progression (during 24-48th months). Cartilage volume measurements (baseline and 24th month loss) were obtained at five knee plates (medial-tibial, lateral-tibial, medial-femoral, lateral-femoral and patellar), and standardized values were analysed. Multivariate logistic regression was used with adjustment for known confounders. Artificial-Neural-Network analysis was conducted by Multi-Layer-Perceptrons (MLPs) including baseline determinants, and baseline (1) and interval changes (2) in cartilage volumes.
  
  
  RESULTS
  Larger baseline lateral-femoral cartilage volume was predictive of medial JSL (OR: 1.29 (1.01-1.64)). Greater initial 24th month lateral-femoral cartilage volume-loss (OR: 0.48 (0.27-0.84)) had protective effect on medial JSL during 24-48th months of study. Baseline and interval changes in lateral-femoral cartilage volume, were the most important estimators for medial JSL progression (importance values: 0.191(0.177-0.204), 0.218(0.207-0.228)) in the ANN analyses.
  
  
  CONCLUSIONS
  Cartilage volumes (both at baseline and their change during the initial 24 months) in the lateral femoral plate were predictive of medial JSL progression.
  
  
  CONCLUSIONS
  • Baseline lateral femoral cartilage volume is directly associated with medial JSL progression. • 24-month lateral femoral cartilage loss is inversely associated with medial JSL progression. • Lateral femoral cartilage volume is most important in association with medial JSL progression.
authors.affiliation: Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline Street, JHOC 5165, Baltimore, MD, 21287, USA.
authors.forename: Nima
authors.initials: N
authors.lastname: Hafezi-Nejad
authors.affiliation: Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Guermazi
authors.affiliation: Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: Frank W
authors.initials: FW
authors.lastname: Roemer
authors.affiliation: Institute of Bone and Joint Research, Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital Sydney, Sydney, Australia.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hunter
authors.affiliation: Biomediq, Copenhagen, Denmark.
authors.forename: Erik B
authors.initials: EB
authors.lastname: Dam
authors.affiliation: Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Bashir
authors.initials: B
authors.lastname: Zikria
authors.affiliation: Division of Rheumatology and Clinical Immunology, University of Arizona, Tucson, AZ, USA.
authors.forename: C Kent
authors.initials: CK
authors.lastname: Kwoh
authors.affiliation: Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline Street, JHOC 5165, Baltimore, MD, 21287, USA. demehri2001@yahoo.com.
authors.forename: Shadpour
authors.initials: S
authors.lastname: Demehri
mesh_terms: D000368:Aged; D015415:Biomarkers; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000473:pathology*; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D005269:Femur / Q000473:pathology; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging; D016015:Logistic Models; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000473:pathology*; D010329:Patella / Q000473:pathology; D011237:Predictive Value of Tests; D013977:Tibia / Q000473:pathology
chemical_list: D015415:Biomarkers
keywords: Cartilage; Knee osteoarthritis; Logistic models; Magnetic resonance imaging; Neural networks