title: Cross-Modality Validation of Acetabular Surface Models Using 3-D Ultrasound Versus Magnetic Resonance Imaging in Normal and Dysplastic Infant Hips.
abstract: Current imaging diagnosis of developmental dysplasia of the hip (DDH) in infancy relies on 2-D ultrasound (US), which is highly operator-dependent. 3-D US offers more complete, and potentially more reliable, imaging of infant hip geometry. We sought to validate the fidelity of acetabular surface models obtained by 3-D US against those obtained concurrently by magnetic resonance imaging (MRI). 3-D US and MRI scans were performed on the same d in 20 infants with normal to severely dysplastic hips (mean age, 57 d; range 13-181 d). 3-D US was performed by two observers using a Philips VL13-5 probe. Coronal 3-D multi-echo data image combination (MEDIC) magnetic resonance (MR) images (1-mm slice thickness) were obtained, usually without sedation, in a 1.5 T Siemens unit. Acetabular surface models were generated for 40 hips from 3-D US and MRI using semi-automated tracing software, separately by three observers. For each hip, the 3-D US and MRI models were co-registered to overlap as closely as possible using Amira software, and the root mean square (RMS) distances between points on the models were computed. 3-D US scans took 3.2 s each. Inter-modality variability was visually minimal. Mean RMS distance between corresponding points on the acetabular surface at 3-D US and MRI was 0.4 ± 0.3 mm, with 95% confidence interval <1 mm. Mean RMS errors for inter-observer and intra-observer comparisons were significantly less for 3-D US than for MRI, while inter-scan and inter-modality comparisons showed no significant difference. Acetabular geometry was reproduced by 3-D US surface models within 1 mm of the corresponding 3-D MRI surface model, and the 3-D US models were more reliable. This validates the fidelity of 3-D US modeling and encourages future use of 3-D US in assessing infant acetabulum anatomy, which may be useful to detect and monitor treatment of hip dysplasia.
authors.affiliation: Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Chad
authors.initials: C
authors.lastname: Diederichs
authors.affiliation: Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Alana
authors.initials: A
authors.lastname: Heath
authors.affiliation: Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Abhilash R
authors.initials: AR
authors.lastname: Hareendranathan
authors.affiliation: Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Dornoosh
authors.initials: D
authors.lastname: Zonoobi
authors.affiliation: Department of Mechanical Engineering, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Gregor
authors.initials: G
authors.lastname: Kuntze
authors.affiliation: Division of Orthopaedic Surgery, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Sukhdeep
authors.initials: S
authors.lastname: Dulai
authors.affiliation: Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Myles G
authors.initials: MG
authors.lastname: Mabee
authors.affiliation: Department of Mechanical Engineering, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Janet L
authors.initials: JL
authors.lastname: Ronsky
authors.affiliation: Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada. Electronic address: jjaremko@ualberta.ca.
authors.forename: Jacob L
authors.initials: JL
authors.lastname: Jaremko
mesh_terms: D000077:Acetabulum / Q000000981:diagnostic imaging*; D006617:Hip Dislocation / Q000000981:diagnostic imaging*; D006621:Hip Joint / Q000000981:diagnostic imaging*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015203:Reproducibility of Results; D014463:Ultrasonography / Q000379:methods*
keywords: 3-D ultrasound; Developmental dysplasia of the hip; Magnetic resonance imaging; Pediatrics