title: Bioimage Informatics for Big Data.
abstract: Bioimage informatics is a field wherein high-throughput image informatics methods are used to solve challenging scientific problems related to biology and medicine. When the image datasets become larger and more complicated, many conventional image analysis approaches are no longer applicable. Here, we discuss two critical challenges of large-scale bioimage informatics applications, namely, data accessibility and adaptive data analysis. We highlight case studies to show that these challenges can be tackled based on distributed image computing as well as machine learning of image examples in a multidimensional environment.
authors.affiliation: Allen Institute for Brain Science, Seattle, WA, USA. hanchuanp@alleninstitute.org.
authors.forename: Hanchuan
authors.initials: H
authors.lastname: Peng
authors.affiliation: Department of Computer Science, Northern Illinois University, Dekalb, IL, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Allen Institute for Brain Science, Seattle, WA, USA.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: Department of Engineering, University Campus Bio-Medico of Rome, Rome, Italy.|Department of Electrical and Information Engineering, University of Cassino and L.M., Cassino, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bria
authors.affiliation: Allen Institute for Brain Science, Seattle, WA, USA.|Department of Computer Science, University of Georgia, Athens, GA, USA.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Li
authors.affiliation: Johns Hopkins University Applied Physics Laboratory, Laurel, MD, USA.
authors.forename: Dean Mark
authors.initials: DM
authors.lastname: Kleissas
authors.affiliation: Johns Hopkins University Applied Physics Laboratory, Laurel, MD, USA.
authors.forename: Nathan G
authors.initials: NG
authors.lastname: Drenkow
authors.affiliation: Allen Institute for Brain Science, Seattle, WA, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Long
authors.affiliation: Allen Institute for Brain Science, Seattle, WA, USA.
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Allen Institute for Brain Science, Seattle, WA, USA.|Department of Computer Science, University of Georgia, Athens, GA, USA.
authors.forename: Hanbo
authors.initials: H
authors.lastname: Chen
mesh_terms: D019295:Computational Biology / Q000379:methods / Q000706:statistics & numerical data*; D003627:Data Interpretation, Statistical; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods / Q000706:statistics & numerical data*; D000069550:Machine Learning; D008856:Microscopy, Fluorescence / Q000295:instrumentation / Q000379:methods; D057054:Molecular Imaging / Q000295:instrumentation / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000706:statistics & numerical data