title: Intraoperative radiation therapy as adjuvant treatment in locally advanced stage tumours involving the middle ear: a hypothesis-generating retrospective study.
abstract: The objective of this study was to evaluate the safety, effectiveness and functional outcomes of intraoperative radiotherapy (IORT) followed by intensity-modulated radiation therapy (IMRT) in locally advanced stage tumours involving the middle ear. Data on 13 consecutive patients treated for malignant tumor of external auditory canal involving the middle ear were retrospectively reviewed. Median follow-up was 33 months (range 6-133). Five (38%) patients were stage III and 8 (62%) were Stage IV according to the University of Pittsburgh staging system. Lateral temporal bone resection (LTBR) was performed in all cases. LTBR was associated with parotidectomy in 5 (38%) cases, and with neck dissection and parotidectomy in 6 (46%) cases. No patients had gross residual tumour. Surgical treatment was followed by IORT (12 Gy) and IMRT (50 Gy). Adjuvant chemotherapy was used in 4 (30%) cases. Preoperative and postoperative audiometric tests were performed to assess hearing loss. 5-year local-control (LC), 5-year distant-metastasis (DM), 5-year disease-free-survival (DFS) and 5-year overall-survival (OS) were calculated with Kaplan-Meyer method. Significant changes in bone conduction were reported after treatment. Partial flap necrosis was the only early complication observed in three (23%) cases, while meningeal fistula was seen in one (7.6%) case as a late complication. The 5-year LC-rate was 68%. The 5-year DM-rate was 90%. The 5-year DFS-rate was 61%. The 5-year OS-rate was 69%. IORT followed by IMRT for the treatment of advanced external auditory canal and middle ear tumours seems to be safe. No intraoperative death was reported. IORT may reduce the postoperative irradiation of remnant tissue obtaining the same full dose on the tumour bed. No complications of the residual external ear were observed. Detriment of neurosensory hearing may be expected. Future studies are required to confirm the benefit of this procedure in the ear.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Regina Elena National Cancer Institute, Rome, Italy;
authors.forename: G
authors.initials: G
authors.lastname: Cristalli
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Regina Elena National Cancer Institute, Rome, Italy;
authors.forename: G
authors.initials: G
authors.lastname: Mercante
authors.affiliation: Department of Radiotherapy, Regina Elena National Cancer Institute, Rome, Italy;
authors.forename: L
authors.initials: L
authors.lastname: Marucci
authors.affiliation: Laboratory of Medical Physics, Regina Elena National Cancer Institute, Rome, Italy;
authors.forename: A
authors.initials: A
authors.lastname: Soriani
authors.affiliation: Department of Neurosurgery, Regina Elena National Cancer Institute, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Telera
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Regina Elena National Cancer Institute, Rome, Italy;
authors.forename: G
authors.initials: G
authors.lastname: Spriano
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D004428:Ear Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D004432:Ear, Middle; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Ear tumours; Hearing loss; IORT; Intraoperative radiotherapy; Middle ear cancer; Toxicity