title: The use of CD47-modified biomaterials to mitigate the immune response.
abstract: Addressing the aberrant interactions between immune cells and biomaterials represents an unmet need in biomaterial research. Although progress has been made in the development of bioinert coatings, identifying and targeting relevant cellular and molecular pathways can provide additional therapeutic strategies to address this major healthcare concern. To that end, we describe the immune inhibitory motif, receptor-ligand pairing of signal regulatory protein alpha and its cognate ligand CD47 as a potential signaling pathway to enhance biocompatibility. The goals of this article are to detail the known roles of CD47-signal regulatory protein alpha signal transduction pathway and to describe how immobilized CD47 can be used to mitigate the immune response to biomaterials. Current applications of CD47-modified biomaterials will also be discussed herein.
authors.affiliation: Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Jillian E
authors.initials: JE
authors.lastname: Tengood
authors.affiliation: Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Levy
authors.affiliation: Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA 19104, USA stachelek@email.chop.edu.
authors.forename: Stanley J
authors.initials: SJ
authors.lastname: Stachelek
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D051928:CD47 Antigen / Q000378:metabolism*; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D015398:Signal Transduction
chemical_list: D001672:Biocompatible Materials; D051928:CD47 Antigen; D007155:Immunologic Factors
keywords: CD47; biomaterials; inflammation; signal regulatory protein alpha