title: Lipidomic Approaches towards Deciphering Glycolipids from Microalgae as a Reservoir of Bioactive Lipids.
abstract: In recent years, noteworthy research has been performed around lipids from microalgae. Among lipids, glycolipids (GLs) are quite abundant in microalgae and are considered an important source of fatty acids (FAs). GLs are rich in 16- and 18-carbon saturated and unsaturated fatty acids and often contain polyunsaturated fatty acids (PUFAs) like n-3 α-linolenic (ALA 18:3), eicosapentaenoic (EPA, 20:5) and docosahexaenoic (DHA, 22:6). GLs comprise three major classes: monogalactosyldiacyl glycerolipids (MGDGs), digalactosyl diacylglycerolipids (DGDGs) and sulfoquinovosyl diacylglycerolipids (SQDGs), whose composition in FA directly depends on the growth conditions. Some of these lipids are high value-added compounds with antitumoral, antimicrobial and anti-inflammatory activities and also with important nutritional significance. To fully explore GLs' bioactive properties it is necessary to fully characterize their structure and to understand the relation between the structure and their biological properties, which can be addressed using modern mass spectrometry (MS)-based lipidomic approaches. This review will focus on the up-to-date FA composition of GLs identified by MS-based lipidomics and their potential as phytochemicals.
authors.affiliation: Centro de Espectrometria de Massa, Departamento de Química &amp; QOPNA, Universidade de Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal. elisabetecosta@ua.pt.
authors.forename: Elisabete
authors.initials: E
authors.lastname: da Costa
authors.affiliation: Allmicroalgae-Natural Products S.A., Avenida das Forças Armadas, 125, 7º piso, 1600-079 Lisboa, Portugal. jglaranjeira2@gmail.com.
authors.forename: Joana
authors.initials: J
authors.lastname: Silva
authors.affiliation: Allmicroalgae-Natural Products S.A., Avenida das Forças Armadas, 125, 7º piso, 1600-079 Lisboa, Portugal. sofia.mendonca@allmicroalgae.com.
authors.forename: Sofia Hoffman
authors.initials: SH
authors.lastname: Mendonça
authors.affiliation: ALGAplus-Produção e Comercialização de Algas e Derivados, Lda., 3830-196 Ílhavo, Portugal. htabreu@algaplus.pt.
authors.forename: Maria Helena
authors.initials: MH
authors.lastname: Abreu
authors.affiliation: Centro de Espectrometria de Massa, Departamento de Química &amp; QOPNA, Universidade de Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal. mrd@ua.pt.
authors.forename: Maria Rosário
authors.initials: MR
authors.lastname: Domingues
mesh_terms: D000818:Animals; D006017:Glycolipids / Q000378:metabolism*; D050356:Lipid Metabolism; D058086:Microalgae / Q000378:metabolism*; D009792:Oceans and Seas
chemical_list: D006017:Glycolipids
keywords: bioprospection; fatty acids; glycolipids; lipidomic; mass spectrometry; microalgae