title: The role of insulin pump therapy for type 2 diabetes mellitus.
abstract: Many patients with type 2 diabetes fail to achieve adequate glucose control despite escalation of treatment and combinations of multiple therapies including insulin. Patients with long-standing type 2 diabetes often suffer from the combination of severe insulin deficiency in addition to insulin resistance, thereby requiring high doses of insulin delivered in multiple injections to attain adequate glycemic control. Insulin-pump therapy was first introduced in the 1970s as an approach to mimic physiological insulin delivery and attain normal glucose in patients with type 1 diabetes. The recent years have seen an increase in the use of this technology for patients with type 2 diabetes. This article summarizes the clinical studies evaluating insulin pump use in patients with type 2 diabetes and discusses the benefits and shortcomings of pump therapy in this population. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Pediatric Endocrine and Diabetes Unit, E. Wolfson Medical Center, Holon, Israel.|Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Zohar
authors.initials: Z
authors.lastname: Landau
authors.affiliation: Diabetes Unit, Department of Internal Medicine, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Itamar
authors.initials: I
authors.lastname: Raz
authors.affiliation: Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.|Diabetes Unit, Wolfson Medical Center, Holon, Israel.
authors.forename: Julio
authors.initials: J
authors.lastname: Wainstein
authors.affiliation: Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.|Diabetes Unit, Wolfson Medical Center, Holon, Israel.
authors.forename: Yosefa
authors.initials: Y
authors.lastname: Bar-Dayan
authors.affiliation: Diabetes Unit, Department of Internal Medicine, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Avivit
authors.initials: A
authors.lastname: Cahn
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage*; D007332:Insulin Infusion Systems / Q000706:statistics & numerical data*; D011379:Prognosis
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin
keywords: continuous subcutaneous insulin infusion; diabetes control; insulin pump; multiple daily injections; type 2 diabetes