title: MBL, P2X7, and SLC11A1 gene polymorphisms in patients with oropharyngeal tularemia.
abstract: CONCLUSIONS
  A significant association was found of oropharyngeal tularemia with SLC11A1 allele polymorphism (INT4 G/C) and MBL2 C + 4T (P/Q). These results indicate C allele and Q allele might be a risk factor for the development of oropharyngeal tularemia.
  
  
  OBJECTIVE
  This study aimed to investigate the relationship of SLC11A1, MBL, and P2X7gene polymorphism with oropharyngeal tularemia.
  
  
  METHODS
  The study included totally 120 patients who were diagnosed with oropharyngeal tularemia. Frequencies of polymorphisms in the following genes were analyzed both in the patient and control groups in the study: SLC11A1 (5'(GT)nAllele 2/3, Int4 G/C, 3' UTR, D543N G/A), MBL (MBL2 C + 4T (P/Q), and P2X7(-762 C/T and 1513 A/C).
  
  
  RESULTS
  Among all polymorphisms that were investigated in this study, SLC11A1 gene showed a significance in the distriburtion of polymorphism allelle frequency at the INT4 region. Frequency of C allele was 54 (28%) in patients with oropharyngeal tularemia, and 31 (13%) in the control group (p = 0.006 and OR = 1.96 (1.21-3.20)). An association was detected between MBL2 C + 4T (P/Q) gene polymorphism and oropharyngeal tularemia (p < 0.005 and OR = 0.30 (0.19-0.48)). No significant relation was found between P2X7(-762 C/T and 1513 A/C) gene polymorphism and oropharyngeal tularemia in this study (p > 0.05).
authors.affiliation: a Faculty of Medicine, Department of Otorhinolaryngology , Gaziosmanpasa University , Tokat , Turkey.
authors.forename: Battal Tahsin
authors.initials: BT
authors.lastname: Somuk
authors.affiliation: b Department of Otorhinolaryngology , Antalya Training and Research Hospital , Antalya , Turkey.
authors.forename: Sema
authors.initials: S
authors.lastname: Koc
authors.affiliation: c Faculty of Medicine, Medical Biology and Genetics , Gaziosmanpasa University , Tokat , Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Ates
authors.affiliation: a Faculty of Medicine, Department of Otorhinolaryngology , Gaziosmanpasa University , Tokat , Turkey.
authors.forename: Göksel
authors.initials: G
authors.lastname: Göktas
authors.affiliation: d Faculty of Medicine, Department of Otorhinolaryngology , Ahi-Evran University , Kirsehir , Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Soyalic
authors.affiliation: e Faculty of Medicine, Department of Otorhinolaryngology , Cumhuriyet University , Sivas , Turkey.
authors.forename: Ismail Onder
authors.initials: IO
authors.lastname: Uysal
authors.affiliation: a Faculty of Medicine, Department of Otorhinolaryngology , Gaziosmanpasa University , Tokat , Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Gurbuzler
authors.affiliation: a Faculty of Medicine, Department of Otorhinolaryngology , Gaziosmanpasa University , Tokat , Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Sapmaz
authors.affiliation: c Faculty of Medicine, Medical Biology and Genetics , Gaziosmanpasa University , Tokat , Turkey.
authors.forename: Saime
authors.initials: S
authors.lastname: Sezer
authors.affiliation: a Faculty of Medicine, Department of Otorhinolaryngology , Gaziosmanpasa University , Tokat , Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Eyibilen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D027682:Cation Transport Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D008875:Middle Aged; D010608:Pharyngeal Diseases / Q000235:genetics*; D011110:Polymorphism, Genetic; D058486:Receptors, Purinergic P2X7 / Q000235:genetics*; D014406:Tularemia / Q000235:genetics*; D055815:Young Adult; D000099173:Natural Resistance-associated Macrophage Protein 1
chemical_list: D027682:Cation Transport Proteins; D037601:Mannose-Binding Lectin; D058486:Receptors, Purinergic P2X7; D000099173:Natural Resistance-associated Macrophage Protein 1; C445619:MBL2 protein, human; C546468:P2RX7 protein, human
keywords: MBL genotypes; NRAMP1 (SLC11A1); P2X7; polymorphism; tularemia