title: Dengue Virus Transmission from Living Donor to Recipient in Liver Transplantation: A Case Report.
abstract: Many infections are transmitted from a donor to a recipient through organ transplantations. The transmission of dengue virus from a donor to a recipient in liver transplantation is a rare entity, and currently, there is no recommendation for screening this virus prior to transplantation. We report a case of transmission of dengue virus from donor to recipient after liver transplantation. The recipient had a history of multiple admissions for hepatic encephalopathy and ascites. He was admitted in the ICU for 15 days for chronic liver disease, ascites, and acute kidney injury before transplantation. The donor was admitted 1 day before transplantation. The donor spiked fever on postoperative day 2 followed by thrombocytopenia and elevated liver enzymes. The donor blood test was positive for dengue NS1 antigen. The recipient also had a similar clinical picture on postoperative day 5 and his blood test was also positive for dengue NS1 antigen. Hence, the diagnosis for posttransplant donor-derived allograft-related transmission of dengue infection was made. Both recipient and donor were treated with supportive measures and discharged after their full recovery on postoperative days 9 and 18, respectively. The effect of immunosuppression on dengue presentation is still unclear and there is lack of literature available. In our case, the recipient developed dengue fever similar to general population without showing any feature of severe graft dysfunction. We have concluded that dengue virus can also be transmitted from donor to recipient, and immunosuppression did not have any adverse effect on the evolution of dengue fever within the recipient. Delhi being a hyperendemic zone, screening for donors (especially in season time) for dengue virus seems to be the best preventive method to control donor-derived transmission of dengue to recipient.
authors.affiliation: Liver Transplantation and GI Surgery, Fortis Escort Liver and Digestive Diseases Institute, Okhla, New Delhi, India.
authors.forename: Raman K
authors.initials: RK
authors.lastname: Gupta
authors.affiliation: Liver Transplantation and GI Surgery, Fortis Escort Liver and Digestive Diseases Institute, Okhla, New Delhi, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Gupta
authors.affiliation: Liver Transplantation and GI Surgery, Fortis Escort Liver and Digestive Diseases Institute, Okhla, New Delhi, India.
authors.forename: Vishal K
authors.initials: VK
authors.lastname: Chorasiya
authors.affiliation: Critical Care Medicine, Fortis Escort Heart Institute, Okhla, New Delhi, India.
authors.forename: Pradyut
authors.initials: P
authors.lastname: Bag
authors.affiliation: Gastroenterology and Hepatology, Fortis Escort Liver and Digestive Diseases Institute, Okhla, New Delhi, India.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Shandil
authors.affiliation: Gastroenterology and Hepatology, Fortis Escort Liver and Digestive Diseases Institute, Okhla, New Delhi, India.
authors.forename: Vikram
authors.initials: V
authors.lastname: Bhatia
authors.affiliation: Gastroenterology and Hepatology, Fortis Escort Liver and Digestive Diseases Institute, Okhla, New Delhi, India.
authors.forename: Manav
authors.initials: M
authors.lastname: Wadhawan
authors.affiliation: Liver Transplantation and GI Surgery, Fortis Escort Liver and Digestive Diseases Institute, Okhla, New Delhi, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Vij
authors.affiliation: Gastroenterology and Hepatology, Fortis Escort Liver and Digestive Diseases Institute, Okhla, New Delhi, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
keywords: AKI, acute kidney injury; ICU, intensive care unit; LDLT, living donor liver transplantation; MELD, model for end-stage liver disease; NS 1 antigen, nonstructural protein 1 antigen; POD, postoperative day; PS for MP, peripheral smear for malaria parasite; SBP, spontaneous bacterial peritonitis; SGOT/SGPT, serum glutamic-oxaloacetic transaminase/serum glutamic-pyruvic transaminase; deg F, degree Fahrenheit; dengue; dengue fever; dengue transmission; living donor liver transplantation; transplantation-related transmission