title: Anti-inflammatory properties of lipoxin A4 protect against diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury.
abstract: Lipoxin A4 can alleviate cerebral ischemia/reperfusion injury by reducing the inflammatory reaction, but it is currently unclear whether it has a protective effect on diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury. In this study, we established rat models of diabetes mellitus using an intraperitoneal injection of streptozotocin. We then induced focal cerebral ischemia/reperfusion injury by occlusion of the middle cerebral artery for 2 hours and reperfusion for 24 hours. After administration of lipoxin A4 via the lateral ventricle, infarction volume was reduced, the expression levels of pro-inflammatory factors tumor necrosis factor alpha and nuclear factor-kappa B in the cerebral cortex were decreased, and neurological functioning was improved. These findings suggest that lipoxin A4 has strong neuroprotective effects in diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury and that the underlying mechanism is related to the anti-inflammatory action of lipoxin A4.
authors.affiliation: Department of Neurology, Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai, Guangdong Province, China.
authors.forename: Jiang-Quan
authors.identifier: 0000-0003-1532-1926
authors.initials: JQ
authors.lastname: Han
authors.affiliation: Department of Neurology, Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai, Guangdong Province, China.
authors.forename: Cheng-Ling
authors.initials: CL
authors.lastname: Liu
authors.affiliation: Department of Neurology, Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai, Guangdong Province, China.
authors.forename: Zheng-Yuan
authors.initials: ZY
authors.lastname: Wang
authors.affiliation: Department of Neurology, Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai, Guangdong Province, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Neurology, Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai, Guangdong Province, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Department of Neurology, Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai, Guangdong Province, China.
authors.forename: Ya-Dan
authors.initials: YD
authors.lastname: Fan
keywords: inflammatory response; nerve regeneration; neural regeneration; nuclear factor-kappa B; tumor necrosis factor alpha