title: The epidemiology of neuromuscular disorders: Age at onset and gender in the Netherlands.
abstract: Based on approximately eight years of data collection with the nationwide Computer Registry of All Myopathies and Polyneuropathies (CRAMP) in the Netherlands, recent epidemiologic information for thirty neuromuscular disorders is presented. This overview includes age and gender data for a number of neuromuscular disorders that are either relatively frequently seen in the neuromuscular clinic, or have a particular phenotype. Since 2004, over 20,000 individuals with a neuromuscular disorder were registered in CRAMP; 56% men and 44% women. The number per diagnosis varied from nine persons with Emery-Dreifuss muscular dystrophy to 2057 persons with amyotrophic lateral sclerosis. Proportions of men ranged from 38% with post-polio syndrome to 68% with progressive spinal muscular atrophy, excluding X-chromosome linked disorders. Inclusion body myositis showed the highest median age at diagnosis of 70 years. These data may be helpful in the diagnostic process in clinical practice and trial readiness.
authors.affiliation: Department of Neurology, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Johanna C W
authors.initials: JC
authors.lastname: Deenen
authors.affiliation: Department of Neurology, Erasmus University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
authors.forename: Pieter A
authors.initials: PA
authors.lastname: van Doorn
authors.affiliation: Department of Neurology, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands.
authors.forename: Catharina G
authors.initials: CG
authors.lastname: Faber
authors.affiliation: Department of Neurology, Academic Medical Centre, University of Amsterdam, Postbus 22660, 1100 DD Amsterdam, The Netherlands.
authors.forename: Anneke J
authors.initials: AJ
authors.lastname: van der Kooi
authors.affiliation: Department of Neurology, University Medical Center Groningen, University of Groningen, NL-9713 AV Groningen, The Netherlands.
authors.forename: Jan B M
authors.initials: JB
authors.lastname: Kuks
authors.affiliation: Department of Neurology, UMC Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.
authors.forename: Nicolette C
authors.initials: NC
authors.lastname: Notermans
authors.affiliation: Department of Neurology, St. Elisabeth Hospital, PO Box 90151, 5000 LC, Tilburg, The Netherlands.
authors.forename: Leo H
authors.initials: LH
authors.lastname: Visser
authors.affiliation: Department of Neurology, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: Corinne G C
authors.initials: CG
authors.lastname: Horlings
authors.affiliation: Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: Jan J G M
authors.initials: JJ
authors.lastname: Verschuuren
authors.affiliation: Department for Health Evidence, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: André L M
authors.initials: AL
authors.lastname: Verbeek
authors.affiliation: Department of Neurology, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: baziel.vanengelen@radboudumc.nl.
authors.forename: Baziel G M
authors.initials: BG
authors.lastname: van Engelen
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D009468:Neuromuscular Diseases / Q000453:epidemiology*; D012737:Sex Factors; D055815:Young Adult
keywords: Age; Epidemiology; Gender; Neuromuscular diseases; Neuromuscular disorders