title: [Anti-obesogenic effect of apple cider vinegar in rats subjected to a high fat diet].
abstract: OBJECTIVE
  The search of new anti-obesogenic treatments based on medicinal plants without or with minimal side effects is a challenge. In this context, the present study was conducted to evaluate the anti-obesogenic effect of apple cider vinegar (ACV) in Wistar rats subjected to a high fat diet.
  
  
  METHODS
  Eighteen male Wistar rats (140±5g) were divided into 3 three equal groups. A witness group submitted to standard laboratory diet and two groups subjected to a high fat diet (cafeteria diet); one receives a daily gavage of apple cider vinegar (7mL/kg/d) for 30 days. Throughout the experiment monitoring the nutritional assessment, anthropometric and biochemical parameters is achieved.
  
  
  RESULTS
  In the RCV vs RC group, we observed a highly significant decrease (P<0.001) in body weight and food intake. On the other hand, the VCP decreases very significantly different anthropometric parameters: BMI (P<0.01), chest circumference and abdominal circumference (P<0.001), decreases serum glucose levels (26.83%) and improves the serum lipid profile by reducing plasma levels of total cholesterol (34.29%), TG (51.06%), LDL-c (59.15%), VLDL (50%) and the total lipid (45.15%), and increasing HDL-c (39.39%), thus offering protection against oatherogenic risk (61.62%).
  
  
  CONCLUSIONS
  This preliminary study indicates that the metabolic disorders caused by high fat diet (cafeteria) are thwarted by taking apple cider vinegar which proves to have a satiating effect, antihyperlipidemic and hypoglycemic effects, and seems prevent the atherogenic risk.
authors.affiliation: Laboratoire de physiologie de la nutrition et de sécurité alimentaire, département de biologie, faculté des sciences de la nature et de la vie, université d'Oran 1 Ahmed Ben Bella, Oran, Algérie. Electronic address: hadjersoumia@gmail.com.
authors.forename: H
authors.initials: H
authors.lastname: Bouderbala
authors.affiliation: Laboratoire de physiologie de la nutrition et de sécurité alimentaire, département de biologie, faculté des sciences de la nature et de la vie, université d'Oran 1 Ahmed Ben Bella, Oran, Algérie.
authors.forename: H
authors.initials: H
authors.lastname: Kaddouri
authors.affiliation: Laboratoire de physiologie de la nutrition et de sécurité alimentaire, département de biologie, faculté des sciences de la nature et de la vie, université d'Oran 1 Ahmed Ben Bella, Oran, Algérie.
authors.forename: O
authors.initials: O
authors.lastname: Kheroua
authors.affiliation: Laboratoire de physiologie de la nutrition et de sécurité alimentaire, département de biologie, faculté des sciences de la nature et de la vie, université d'Oran 1 Ahmed Ben Bella, Oran, Algérie.
authors.forename: D
authors.initials: D
authors.lastname: Saidi
mesh_terms: D019342:Acetic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects*; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D008297:Male; D027845:Malus; D009765:Obesity / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D019342:Acetic Acid
keywords: Anthropometry; Anthropométrie; Antihyperlipidemic effect; Apple cider vinegar; Cardiovascular disease; Effet hypolipémiant; Maladies cardiovasculaires; Non-drug treatments; Obesity; Obésité; Traitements non médicamenteux; Vinaigre de cidre de pomme