title: Cell-specific synaptic plasticity induced by network oscillations.
abstract: Gamma rhythms are known to contribute to the process of memory encoding. However, little is known about the underlying mechanisms at the molecular, cellular and network levels. Using local field potential recording in awake behaving mice and concomitant field potential and whole-cell recordings in slice preparations we found that gamma rhythms lead to activity-dependent modification of hippocampal networks, including alterations in sharp wave-ripple complexes. Network plasticity, expressed as long-lasting increases in sharp wave-associated synaptic currents, exhibits enhanced excitatory synaptic strength in pyramidal cells that is induced postsynaptically and depends on metabotropic glutamate receptor-5 activation. In sharp contrast, alteration of inhibitory synaptic strength is independent of postsynaptic activation and less pronounced. Further, we found a cell type-specific, directionally biased synaptic plasticity of two major types of GABAergic cells, parvalbumin- and cholecystokinin-expressing interneurons. Thus, we propose that gamma frequency oscillations represent a network state that introduces long-lasting synaptic plasticity in a cell-specific manner.
authors.affiliation: Institute of Neurophysiology, Charité -Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Shota
authors.initials: S
authors.lastname: Zarnadze
authors.affiliation: Institute of Neurophysiology, Charité -Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Bäuerle
authors.affiliation: Institute of Neurophysiology, Charité -Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Julio
authors.initials: J
authors.lastname: Santos-Torres
authors.affiliation: Neuroscience Research Center, Charité -Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Böhm
authors.affiliation: Neuroscience Research Center, Charité -Universitätsmedizin Berlin, Berlin, Germany.|The NeuroCure Cluster of Excellence, Berlin, Germany.|Bernstein Center for Computational Neuroscience, Berlin, Germany.
authors.forename: Dietmar
authors.initials: D
authors.lastname: Schmitz
authors.affiliation: Institute of Neurophysiology, Charité -Universitätsmedizin Berlin, Berlin, Germany.|The NeuroCure Cluster of Excellence, Berlin, Germany.
authors.forename: Jörg Rp
authors.initials: JR
authors.lastname: Geiger
authors.affiliation: Institute of Neurophysiology, Charité -Universitätsmedizin Berlin, Berlin, Germany.|The NeuroCure Cluster of Excellence, Berlin, Germany.
authors.forename: Tamar
authors.initials: T
authors.lastname: Dugladze
authors.affiliation: Institute of Neurophysiology, Charité -Universitätsmedizin Berlin, Berlin, Germany.|Bernstein Center for Computational Neuroscience, Berlin, Germany.
authors.forename: Tengis
authors.identifier: 0000-0002-2209-375X
authors.initials: T
authors.lastname: Gloveli
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000235:genetics / Q000378:metabolism; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D059330:GABAergic Neurons / Q000166:cytology / Q000378:metabolism*; D065818:Gamma Rhythm / Q000502:physiology*; D015870:Gene Expression; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism; D007395:Interneurons / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009415:Nerve Net / Q000378:metabolism / Q000648:ultrastructure; D009473:Neuronal Plasticity / Q000502:physiology*; D009928:Organ Specificity; D010320:Parvalbumins / Q000235:genetics / Q000378:metabolism; D018408:Patch-Clamp Techniques; D017966:Pyramidal Cells / Q000166:cytology / Q000378:metabolism*; D064529:Receptor, Metabotropic Glutamate 5 / Q000235:genetics / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D010320:Parvalbumins; D064529:Receptor, Metabotropic Glutamate 5; D002766:Cholecystokinin
keywords: gamma rhythms; interneuron; mGluR5; mouse; neuroscience; patch-clamp methodology; sharp wave ripples; synaptic plasticity