title: NEURL rs6584555 and CAND2 rs4642101 contribute to postoperative atrial fibrillation: a prospective study among Chinese population.
abstract: Postoperative atrial fibrillation (POAF) is a serious, common complication after coronary artery bypass grafting (CABG) surgery. Recently, 5 novel loci were identified to be associated with atrial fibrillation susceptibility using a combination of genotyping, eQTL mapping, and functional validation. In current study, we aim to evaluated the positive findings for POAF susceptibility after CABG among Chinese population, using a population-based, two-stage, nested case-control study with 1,400 patients. NEURL rs12415501 and CAND2 rs4642101 were significantly associated with POAF susceptibility after CABG among Chinese population in both stages. When pooled together, the ORs for each additional copy of minor allele was 1.29 (95% CI: 1.13-1.48, P = 1.7×10-4) for NEURL rs12415501, and 1.21 (95% CI: 1.08-1.36, P = 9.8×10-4) for CAND2 rs4642101. Functional validation experiments found the AF risk allele of NEURL rs6584555 and CAND2 rs4642101 correlated with an increased expression of its corresponding genes (P<0.001). In this independently collected cardiac surgery cohort, we replicated the previous findings, and 2 novel loci are independently associated with POAF risk in patients who undergo CABG surgery in Chinese population.
authors.affiliation: Vasculocardiology Department, The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui, Lishui, Zhejiang, P.R. China.
authors.forename: Tiemin
authors.initials: T
authors.lastname: Wei
authors.affiliation: Department of Radiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui, Lishui, Zhejiang, P.R. China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Radiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui, Lishui, Zhejiang, P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.affiliation: Vasculocardiology Department, The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui, Lishui, Zhejiang, P.R. China.
authors.forename: Lingchun
authors.initials: L
authors.lastname: Lv
authors.affiliation: Vasculocardiology Department, The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui, Lishui, Zhejiang, P.R. China.
authors.forename: Chong
authors.initials: C
authors.lastname: Liu
authors.affiliation: Vasculocardiology Department, The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui, Lishui, Zhejiang, P.R. China.
authors.forename: Jiayi
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Cardiology, Sichuan Medical University, Sichuan, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000368:Aged; D044466:Asian People; D001281:Atrial Fibrillation / Q000150:complications / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D001026:Coronary Artery Bypass / Q000009:adverse effects; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011183:Postoperative Complications / Q000235:genetics; D011184:Postoperative Period; D011446:Prospective Studies; D012044:Regression Analysis; D014157:Transcription Factors / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
chemical_list: C485649:CAND2 protein, human; D009124:Muscle Proteins; D014157:Transcription Factors; C556508:NEURL1 protein, human; D044767:Ubiquitin-Protein Ligases
keywords: SNP; atrial fibrillation; coronary artery bypass graft surgery; susceptibility