title: Antitumor effect of arabinogalactan and platinum complex.
abstract: The article presents the results of investigation of antitumor properties of platinum-arabinogalactan complex. We showed the ability of the complex to inhibit the growth of Ehrlich ascites tumor cells. It is found that the distribution of the platinum-arabinogalactan complex is not specific only for tumor cells in mice. The complex was found in all tissues and organs examined (ascites cells, embryonic cells, kidney, and liver). The mechanism of action of the arabinogalactan-platinum complex may be similar to cisplatin as the complex is able to accumulate in tumor cells.
authors.affiliation: Institute of Chemistry and Chemical Technology, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, Russia.
authors.forename: A K
authors.initials: AK
authors.lastname: Starkov
authors.affiliation: Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk krai, 660022, Russia. tzamay@yandex.ru.|Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia. tzamay@yandex.ru.|Kirenskii Institute of Physics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia. tzamay@yandex.ru.
authors.forename: T N
authors.initials: TN
authors.lastname: Zamay
authors.affiliation: Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk krai, 660022, Russia.|Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Savchenko
authors.affiliation: Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk krai, 660022, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Ingevatkin
authors.affiliation: Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia.
authors.forename: N M
authors.initials: NM
authors.lastname: Titova
authors.affiliation: Voino-Yasenetskii State Medical University, Ministry of Health of the Russian Federation, ul. Partizana Zheleznyaka 1, Krasnoyarsk, Krasnoyarsk krai, 660022, Russia.|Kirenskii Institute of Physics, Siberian Branch, Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Kolovskaya
authors.affiliation: Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Luzan
authors.affiliation: Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia.
authors.forename: P P
authors.initials: PP
authors.lastname: Silkin
authors.affiliation: Institute of Chemistry and Chemical Technology, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, Russia.|Siberian Federal University, Svobodnyi pr. 79, Krasnoyarsk, 660041, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Kuznetsova
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*; D001201:Ascites / Q000188:drug therapy / Q000378:metabolism; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000378:metabolism; D002945:Cisplatin / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005685:Galactans / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008813:Mice, Inbred ICR; D008856:Microscopy, Fluorescence; D009368:Neoplasm Transplantation; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D005685:Galactans; D009944:Organoplatinum Compounds; D002945:Cisplatin