title: The Syntheses, Structures, Fluorescence Properties and Biological Activity of two Novel Zinc(II) Complexes Controlled by the Tripodal Imidazole Ligand.
abstract: Two new zinc complexes, namely Zn(L(1))ClCH2NO(1) and {Zn(L(2))CH2NO}n▪N(CH3)3▪ClO4(2) (L(1) = 3,5-di(1H-imidazol-1-yl)pyridine L(2) = 1,3,5-tris(1-imidazolyl) benzene), have been synthesized, and characterized by IR spectra, elemental analysis, and a single crystal X-ray diffraction. Fluorescence spectroscopy indicated that two complexes presented strong DNA binding affinity constants to fish sperm DNA (FS-DNA). Gel electrophoresis assay demonstrated the ability of the complex to cleave the HL-60 DNA. Apoptotic study showed the complex exhibited significant cancer cell(KB) inhibitory rate.
authors.affiliation: The key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, 110142, China. enjungao@163.com.
authors.forename: En-Jun
authors.initials: EJ
authors.lastname: Gao
authors.affiliation: The key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, 110142, China.
authors.forename: Shaozhong
authors.initials: S
authors.lastname: Zhang
authors.affiliation: The key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, 110142, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Meng
authors.affiliation: The key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, 110142, China.
authors.forename: Fu-Chen
authors.initials: FC
authors.lastname: Zhao
authors.affiliation: The key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, 110142, China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Ma
authors.affiliation: The key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, 110142, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Jin
authors.affiliation: The key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, 110142, China.
authors.forename: Si-Jia
authors.initials: SJ
authors.lastname: Liu
authors.affiliation: The key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, 110142, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ge
authors.affiliation: The key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, 110142, China.
authors.forename: Ya-Guang
authors.initials: YG
authors.lastname: Sun
authors.affiliation: The key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, 110142, China.
authors.forename: Wan-Zhong
authors.initials: WZ
authors.lastname: Zhang
authors.affiliation: The key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, 110142, China. mczhu@syuct.edu.cn.
authors.forename: Ming-Chang
authors.initials: MC
authors.lastname: Zhu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D007624:KB Cells; D008024:Ligands; D013050:Spectrometry, Fluorescence; D015032:Zinc / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D007093:Imidazoles; D008024:Ligands; D004247:DNA; D015032:Zinc
keywords: 1,3,5-tris(1-imidazolyl)benzene; 3,5-di(1H-imidazol-1-yl)pyridine; Cancer cell inhibition; Crystal structure