title: Stage I and II Stress Incontinence (SIC): High dosed vitamin D may improve effects of local estriol.
abstract: After the age of 55 almost every third woman suffers from conditions of the incapability to retain urine when the intra-abdominal pressure is raised by different causes. So called stress incontinence. It' s caused by a predisposition in the family, weakness of the tissue, physical strain, deficiency in the metabolism, especially an increasing local estrogen deficiency and a local and systemic vitamin D deficiency.
  
  
  METHODS
  We evaluated the data of 60 meno- and postmenopausal female patients with a stress incontinence (SIC). All had a SIC in spite of a former local estriol treatment with a treatment of OeKolp® forte (= 0.5 mg estriol/ov), 3 times a week, for 6 weeks and in spite of a regular pelvic floor exercise for 6 weeks in the morning and in the evening, according to the protocol. Thirty were in stage I SIC and 30 were in stage II SIC.
  
  
  METHODS
  We evaluated vitamin-D-levels in serum of our 60 postmenopausal women. Only 20% of this group had good vitamin D-levels. The medical intervention combined estriol (0.5 mg) together with high dosed vitamin D (12.500 I.U.) locally 3 times a week for a period of 6 weeks. The patients also had the instruction to continue their daily exercises in pelvic floor (morning and evening, due to their protocol). After six weeks of treatment the vitamin D level in serum was defined and correlated to the patients condition (symptomatic of stress incontinence, protocol of micturitions, Pad-test).
  
  
  RESULTS
  About one-third of women from our test assigned to be now capable of retaining urine. More than one-third of our patients cleared a profit of treatment. They reported mimimum regression about 25% of volume of incontinence. Therefore more than 2-third of our women being incapable of retaining urine improved their body conditions by using a combination of locally administered etriol and high dosed vitamin D.
  
  
  CONCLUSIONS
  Stress incontinence (being incapable of retaining urine when the intra-abdominal pressure arises) in lower and middle grade, improves their body conditions under a combination of local administered estriol and vitamin D. This small study is not representative. We need much bigger studies with much more dates and with a follow up.
authors.affiliation: Gynecologist, Endocrinology, Oncology, Umweltmedizinisches Therapiezentrum am Dom , München, Germany.
authors.forename: Claus
authors.initials: C
authors.lastname: Schulte-Uebbing
authors.affiliation: Arzt und Apotheker, Klösterl-Apotheke , München, Germany.
authors.forename: Siegfried
authors.initials: S
authors.lastname: Schlett
authors.affiliation: Ordinarius, Dep. Gynecology and Obstetrics, Int. University of Oradea , Oradea, Romania.
authors.forename: Doru
authors.initials: D
authors.lastname: Craiut
authors.affiliation: Ordinarius, Dep. Urology, Int. University of Oradea , Oradea, Romania.
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Bumbu
keywords: SIC; cholecalciferol; estriol; high dosed vaginal vitamin D; pelvic floor weakness; stress incontinence; vitamin D