title: Management of cardiovascular disease in patients with psoriasis.
abstract: BACKGROUND
  Patients with psoriasis have an increased incidence and prevalence of cardiovascular (CV) risk factors, and CV undertreatment in these patients is a well-established problem. The link between psoriasis and CV disease is present on a pathogenic level, as well as due to modifiable lifestyle factors such as smoking and alcohol abuse.
  
  
  METHODS
  In this manuscript we describe the evidence associating psoriasis with CV disease, as well as the pharmacological and non-pharmacological treatment of CV risk factors including the CV effects of anti-psoriatic therapy and vice versa.
  
  
  CONCLUSIONS
  Current guidelines recommend that patients with psoriasis are screened for CV risk factors, and recommend smoking cessation, reduced alcohol consumption, altering of lifestyle to move to a normal-weight body-mass index, exercising 3 times a week for 30 minutes, and monitoring and modifying cholesterol levels, respectively. While the current sum of evidence is not sufficient to recommend specific therapies for psoriasis solely based on their potential CV impact, some guidelines have suggested a 1.5 multiplication factor, in patients with severe psoriasis, to the Framingham risk score. Indeed, the importance of screening for CV risk factors and strict adherence to established primary and secondary preventive measures in these patients should be emphasized.
authors.affiliation: a Department of Dermato-Allergology, Herlev and Gentofte Hospital , University of Copenhagen , Hellerup , Denmark.
authors.forename: Alexander
authors.initials: A
authors.lastname: Egeberg
authors.affiliation: a Department of Dermato-Allergology, Herlev and Gentofte Hospital , University of Copenhagen , Hellerup , Denmark.
authors.forename: Lone
authors.initials: L
authors.lastname: Skov
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology / Q000628:therapy; D000437:Alcoholism / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy*; D019468:Disease Management; D006801:Humans; D011565:Psoriasis / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy*; D012307:Risk Factors; D040242:Risk Reduction Behavior
keywords: Cardiovascular disease; inflammation; psoriasis; therapy