title: Studies towards the synthesis of tedanolide C. Construction of the C13-epi C1-C15 fragment.
abstract: The preparation of an advanced intermediate on route towards the synthesis of tedanolide C is reported here. It is based on the coupling of two fragments of similar size and complexity, which in turn are prepared by highly stereoselective substrate-controlled titanium-mediated aldol reactions from chiral ketones.
authors.affiliation: Secció de Química Orgànica, Departament de Química Inorgànica i Orgànica, and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Carrer Martí i Franqués 1-11, 08028 Barcelona, Catalonia, Spain. pedro.romea@ub.edu felix.urpi@ub.edu.
authors.forename: Joana
authors.initials: J
authors.lastname: Zambrana
authors.forename: Pedro
authors.initials: P
authors.lastname: Romea
authors.forename: Fèlix
authors.initials: F
authors.lastname: Urpí
mesh_terms: D060326:Chemistry Techniques, Synthetic; D007659:Ketones / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D018942:Macrolides; C516408:tedanolide C