title: Solanum tuberosum and Lycopersicon esculentum Leaf Extracts and Single Metabolites Affect Development and Reproduction of Drosophila melanogaster.
abstract: Glycoalkaloids are secondary metabolites commonly found in Solanaceae plants. They have anti-bacterial, anti-fungal and insecticidal activities. In the present study we examine the effects of potato and tomato leaf extracts and their main components, the glycoalkaloids α-solanine, α-chaconine and α-tomatine, on development and reproduction of Drosophila melanogaster wild-type flies at different stages. Parental generation was exposed to five different concentrations of tested substances. The effects were examined also on the next, non-exposed generation. In the first (exposed) generation, addition of each extract reduced the number of organisms reaching the pupal and imaginal stages. Parent insects exposed to extracts and metabolites individually applied showed faster development. However, the effect was weaker in case of single metabolites than in case of exposure to extracts. An increase of developmental rate was also observed in the next, non-exposed generation. The imagoes of both generations exposed to extracts and pure metabolites showed some anomalies in body size and malformations, such as deformed wings and abdomens, smaller black abdominal zone. Our results further support the current idea that Solanaceae can be an impressive source of molecules, which could efficaciously be used in crop protection, as natural extract or in formulation of single pure metabolites in sustainable agriculture.
authors.affiliation: Department of Sciences, University of Basilicata, Potenza, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Ventrella
authors.affiliation: Electron and Confocal Microscope Laboratory, Adam Mickiewicz University, Poznań, Poland.|Department of Animal Physiology and Developmental Biology, Adam Mickiewicz University, Poznań, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Adamski
authors.affiliation: Department of Genetics, Adam Mickiewicz University, Poznań, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Chudzińska
authors.affiliation: Department of Genetics, Adam Mickiewicz University, Poznań, Poland.
authors.forename: Mariola
authors.initials: M
authors.lastname: Miądowicz-Kobielska
authors.affiliation: Department of Animal Physiology and Developmental Biology, Adam Mickiewicz University, Poznań, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Marciniak
authors.affiliation: Department of Molecular Biology and Genetics, Bülent Ecevit University, Zonguldak, Turkey.
authors.forename: Ender
authors.initials: E
authors.lastname: Büyükgüzel
authors.affiliation: Department of Biology, Faculty of Arts and Science, Bülent Ecevit University, Zonguldak, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Büyükgüzel
authors.affiliation: Bülent Ecevit University Ahmet Erdoğan Vocational School of Health Services, Zonguldak, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Erdem
authors.affiliation: Department of Sciences, University of Basilicata, Potenza, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Falabella
authors.affiliation: Department of European and Mediterranean Cultures, University of Basilicata, Matera, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Scrano
authors.affiliation: Department of Sciences, University of Basilicata, Potenza, Italy.
authors.forename: Sabino Aurelio
authors.initials: SA
authors.lastname: Bufo
mesh_terms: D000818:Animals; D049628:Body Size / Q000187:drug effects; D004331:Drosophila melanogaster / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D005260:Female; D018551:Solanum lycopersicum / Q000737:chemistry*; D008297:Male; D010572:Pest Control, Biological; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D012098:Reproduction / Q000187:drug effects*; D012992:Solanine / Q000031:analogs & derivatives / Q000494:pharmacology; D011198:Solanum tuberosum / Q000737:chemistry*; D014053:Tomatine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; C514919:alpha-solanine; C484751:alpha-tomatine; D012992:Solanine; C011860:alpha-chaconine; D014053:Tomatine