title: Image guided surgery in the management of head and neck cancer.
abstract: Complete resection of head and neck tumors relies on palpation and visual inspection. Achieving a negative margin in remote locations in the head and neck region, especially in close proximity to critical structures, is often difficult to achieve. Positive resection margins in head and neck cancer are at high risk to develop recurrent disease and associated with poor prognosis. Near-infrared fluorescence-guided optical imaging is an emerging technology with the potential to move the surgical field forward and facilitate surgeons to visualize tumors in real-time intra-operatively. In this review, our focus is to discuss the recent advances and the potential application of near infrared (NIR) fluorescent-guided surgery in the management of head and neck cancer.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center and Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. Electronic address: iqbal.56@osu.edu.
authors.forename: Hassan
authors.initials: H
authors.lastname: Iqbal
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center and Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. Electronic address: Quintin.Pan@osumc.edu.
authors.forename: Quintin
authors.initials: Q
authors.lastname: Pan
mesh_terms: D005453:Fluorescence; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D025321:Surgery, Computer-Assisted
keywords: Fluorescence molecular imaging; Head and neck neoplasm; Image guided surgery; Near infrared fluorescence; Sentinel lymph node; Squamous cell carcinoma