title: Current physico-biochemistry in steroid research and status of structural biology for steroid-converting enzymes.
authors.affiliation: Axe of Endocrinology and Nephrology, CHU research center and Faculty of Medicine, Laval University; Quebec, Canada. Electronic address: sxlin@crchul.ulaval.ca.
authors.forename: S X
authors.initials: SX
authors.lastname: Lin
authors.affiliation: Département de Biochimie, de Microbiologie et de Bio-Informatique, IBIS et PROTEO, Université Laval, Pavillon Charles-Eugène Marchand, Québec City, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Shi
authors.affiliation: School of Life Sciences, Fudan University, Shanghai 200438, PR China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Hu
authors.affiliation: Center of Excellence in Environmental Toxicology, Department of Systems, Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, United States.
authors.forename: T M
authors.initials: TM
authors.lastname: Penning
mesh_terms: D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007700:Kinetics; D010088:Oxidoreductases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D025941:Protein Interaction Mapping; D011944:Receptors, Androgen / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D011960:Receptors, Estrogen / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D013256:Steroids / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D004791:Enzyme Inhibitors; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D013256:Steroids; D010088:Oxidoreductases; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1; C021936:3-oxo-5 beta-steroid delta 4-dehydrogenase