title: The International Deep Brain Stimulation Registry and Database for Gilles de la Tourette Syndrome: How Does It Work?
abstract: Tourette Syndrome (TS) is a neuropsychiatric disease characterized by a combination of motor and vocal tics. Deep brain stimulation (DBS), already widely utilized for Parkinson's disease and other movement disorders, is an emerging therapy for select and severe cases of TS that are resistant to medication and behavioral therapy. Over the last two decades, DBS has been used experimentally to manage severe TS cases. The results of case reports and small case series have been variable but in general positive. The reported interventions have, however, been variable, and there remain non-standardized selection criteria, various brain targets, differences in hardware, as well as variability in the programming parameters utilized. DBS centers perform only a handful of TS DBS cases each year, making large-scale outcomes difficult to study and to interpret. These limitations, coupled with the variable effect of surgery, and the overall small numbers of TS patients with DBS worldwide, have delayed regulatory agency approval (e.g., FDA and equivalent agencies around the world). The Tourette Association of America, in response to the worldwide need for a more organized and collaborative effort, launched an international TS DBS registry and database. The main goal of the project has been to share data, uncover best practices, improve outcomes, and to provide critical information to regulatory agencies. The international registry and database has improved the communication and collaboration among TS DBS centers worldwide. In this paper we will review some of the key operation details for the international TS DBS database and registry.
authors.affiliation: Department of Neurology, University of Florida and Center for Movement Disorders and Neurorestoration Gainesville, FL, USA.
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authors.affiliation: Department of Neurology, University of Florida and Center for Movement Disorders and Neurorestoration Gainesville, FL, USA.
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authors.affiliation: Sobell Department of Motor Neuroscience, University College London Institute of Neurology London, UK.
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authors.affiliation: Sobell Department of Motor Neuroscience, University College London Institute of Neurology London, UK.
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authors.affiliation: Institut National de la Santé et de la Recherche Médicale U 1127, Centre National de la Recherche Scientifique UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinièreParis, France; Department of Neurosurgery, Assistance Publique - Hôpitaux de Paris, Hôpital de la Pitié-SalpêtrièreParis, France.
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keywords: Tourette syndrome; database; deep brain stimulation; registry; regulatory agencies; tics