title: Inherited combined deficiency of factors XI and XII with von Willebrand's disease.
abstract: Combined hereditary deficiency of factors XI (FXI) and XII (FXII) associated with the deficeincy of von Willebrand factor (vWF) in a single patient has not been reported so far in the literature. We report on two brothers of non-Jewish stock with defciency of FXI, FXII and vWF. The family studies disclosed FXI and FXII deficiency in the mother of propositi. A maternal niece had FXII deficiency. The father of propositi had vWF deficiency. This study suggests possible existence of a regulatory factor common to genes specifying FXI and FXII. Associated vWF deficiency is coincidental.
authors.affiliation: Institute of Hematology, University Clinical Center of Serbia, 11000 Beograd, ul.Koste Todorovica br 2, Yugoslavia.
authors.forename: M D
authors.initials: MD
authors.lastname: Čolović
authors.affiliation: Institute of Hematology, University Clinical Center of Serbia, 11000 Beograd, ul.Koste Todorovica br 2, Yugoslavia.
authors.forename: P
authors.initials: P
authors.lastname: Miljić
authors.affiliation: Institute of Hematology, University Clinical Center of Serbia, 11000 Beograd, ul.Koste Todorovica br 2, Yugoslavia.
authors.forename: R B
authors.initials: RB
authors.lastname: Čolović
authors.affiliation: Institute of Hematology, University Clinical Center of Serbia, 11000 Beograd, ul.Koste Todorovica br 2, Yugoslavia.
authors.forename: G
authors.initials: G
authors.lastname: Janković
keywords: FXI and FXII deficiency; combined factor deficiency; vWF