title: Fabrication of Dendrimer-Based Polyion Complex Submicrometer-Scaled Structures with Enhanced Stability under Physiological Conditions.
abstract: Submicrometer-scaled (subμ-) self-assembled materials have been developed based on polyion complex (PIC) formation, in particular for biomedical-applications. However, sufficient stability under physiological conditions is required for their practical use. In this study, PIC formation behavior is examined using a block aniomer, poly(ethylene glycol)-b-poly(aspartic acid), and homocatiomers, poly(l-lysine) (LPK) and dendritic poly(l-lysine) (DPK) with different generations, to elucidate the contribution of the dendritic architecture to stability enhancement. LPK-based PIC shows a subμ-vesicular structure only at 25 °C in the absence of NaCl; in contrast, DPK-based PIC forms a subμ-structure under physiological salt concentration and temperature conditions, even when the number of charges of a single molecule is much smaller than that of LPK. Moreover, the formation of subμ-vesicular and -spherical micellar structures is dependent on DPK generation. Thus, the molecular backbone architecture of the PIC component plays an important role not only in expanding the preparation conditions and enhancing stability, but also in controlling the self-assembled structures, mainly due to the spatially restricted structures of dendrimers.
authors.affiliation: Graduate School of Systems Life Sciences, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.
authors.forename: Kenshiro
authors.initials: K
authors.lastname: Naoyama
authors.affiliation: Graduate School of Systems Life Sciences, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.|Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.|Center for Future Chemistry, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mori
authors.affiliation: Graduate School of Systems Life Sciences, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.|Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.|Center for Future Chemistry, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.|Center for Molecular Systems, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.|Center for Advanced Medical Innovation, Kyushu University, 3-1-1 Maedashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Katayama
authors.affiliation: Graduate School of Systems Life Sciences, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.|Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.|Center for Molecular Systems, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kishimura
mesh_terms: D002627:Chemistry, Physical; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D007477:Ions / Q000138:chemical synthesis / Q000737:chemistry; D008823:Micelles; D015394:Molecular Structure; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D012965:Sodium Chloride / Q000737:chemistry; D013499:Surface Properties; D013696:Temperature
chemical_list: D050091:Dendrimers; D007477:Ions; D008823:Micelles; D011108:Polymers; D012965:Sodium Chloride
keywords: block copolymers; dendrimers; polyelectrolytes; self-organization; vesicles