title: The Intrinsic Fragility of DNA (Nobel Lecture).
abstract: Our cells contain common molecules, such as water or oxygen, that can damage DNA. In his studies Tomas Lindahl has shown how specific repair enzymes remove and replace damaged parts of DNA in a process of vital importance.
authors.affiliation: Cancer Research UK, Clare Hall Laboratories, Hertfordshire, EN6 3LD, UK. tomas.lindahl@crick.ac.uk.
authors.forename: Tomas
authors.initials: T
authors.lastname: Lindahl
mesh_terms: D000477:Alkylating Agents / Q000737:chemistry; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004249:DNA Damage; D045647:DNA Glycosylases / Q000378:metabolism; D019175:DNA Methylation; D004260:DNA Repair; D012436:S-Adenosylmethionine / Q000737:chemistry
chemical_list: D000477:Alkylating Agents; D012436:S-Adenosylmethionine; D004247:DNA; D045647:DNA Glycosylases
keywords: DNA repair; Nobel lecture; base mismatch; repair enzymes