title: Application of nanostructured drug delivery systems in immunotherapy of cancer: a review.
abstract: The cancer immunotherapy method uses the specificity of the immune system to provide a more effective than more conventional treatments, such as chemotherapy and radiotherapy. Immunotherapy has two main strategies (passive or active) to organize the immune system. Passive strategies use advantage of tumor-hyperpermeable cells, which have enhanced permeability and retention effects. Nanoparticles due to their better accumulation within tissues and cells of the immune system are well suitable for delivery of immune therapies such as vaccines or adjuvants. In this review, we explained application of nanotechnology in immunotherapy of cancer.
authors.affiliation: a Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences , Tabriz University of Medical Sciences , Tabriz , Iran.|b Student Research Committee , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Nahideh
authors.initials: N
authors.lastname: Asadi
authors.affiliation: a Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Soodabeh
authors.initials: S
authors.lastname: Davaran
authors.affiliation: c Chemical Injuries Research Center , Baqiyatallah University of Medical Sciences , Tehran , Iran.
authors.forename: Yunes
authors.initials: Y
authors.lastname: Panahi
authors.affiliation: d Laboratory of Biochemistry, Department of Biology, Faculty of Natural Sciences , University of Tabriz , Tabriz , Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Hasanzadeh
authors.affiliation: e Department of New Sciences and Technologies , University of Tehran , Tehran , Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Malakootikhah
authors.affiliation: f Department of Chemistry, Faculty of Science , University of Guilan , Rasht , Iran.
authors.forename: Hadi
authors.initials: H
authors.lastname: Fallah Moafi
authors.affiliation: a Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences , Tabriz University of Medical Sciences , Tabriz , Iran.|b Student Research Committee , Tabriz University of Medical Sciences , Tabriz , Iran.|c Chemical Injuries Research Center , Baqiyatallah University of Medical Sciences , Tehran , Iran.|g Drug Applied Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D053758:Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*
keywords: Cancer; EPR; chemotherapy; immunotherapy