title: Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis.
abstract: Periostin (POSTN) is a limiting factor in the metastatic colonization of disseminated tumour cells. However, the role of POSTN in regulating the immunosuppressive function of immature myeloid cells in tumour metastasis has not been documented. Here, we demonstrate that POSTN promotes the pulmonary accumulation of myeloid-derived suppressor cells (MDSCs) during the early stage of breast tumour metastasis. Postn deletion decreases neutrophil and monocytic cell populations in the bone marrow of mice and suppresses the accumulation of MDSCs to premetastatic sites. We also found that POSTN-deficient MDSCs display reduced activation of ERK, AKT and STAT3 and that POSTN deficiency decreases the immunosuppressive functions of MDSCs during tumour progression. Moreover, the pro-metastatic role of POSTN is largely limited to ER-negative breast cancer patients. Lysyl oxidase contributes to POSTN-promoted premetastatic niche formation and tumour metastasis. Our findings indicate that POSTN is essential for immunosuppressive premetastatic niche formation in the lungs during breast tumour metastasis and is a potential target for the prevention and treatment of breast tumour metastasis. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, People's Republic of China.|Engineering Research Centre of Molecular Diagnostics, Ministry of Education, School of Life Sciences, Xiamen University, People's Republic of China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, People's Republic of China.|Engineering Research Centre of Molecular Diagnostics, Ministry of Education, School of Life Sciences, Xiamen University, People's Republic of China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Xiong
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, People's Republic of China.|Medical College of Xiamen University, People's Republic of China.
authors.forename: Yubin
authors.initials: Y
authors.lastname: Mao
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, People's Republic of China.
authors.forename: Mimi
authors.initials: M
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, People's Republic of China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, People's Republic of China.
authors.forename: Xueliang
authors.initials: X
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, People's Republic of China.
authors.forename: Zhenling
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Medical College of Xiamen University, People's Republic of China.
authors.forename: Fan
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital of Xiamen University, People's Republic of China.
authors.forename: Zhengjie
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital of Xiamen University, People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, People's Republic of China.|Engineering Research Centre of Molecular Diagnostics, Ministry of Education, School of Life Sciences, Xiamen University, People's Republic of China.
authors.forename: Gaoliang
authors.initials: G
authors.lastname: Ouyang
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D007108:Immune Tolerance / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D000072737:Myeloid-Derived Suppressor Cells / Q000378:metabolism / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D015815:Cell Adhesion Molecules; C082838:Postn protein, mouse
keywords: breast cancer; metastasis; myeloid-derived suppressor cell; periostin; premetastatic niche