title: 'RE:fine drugs': an interactive dashboard to access drug repurposing opportunities.
abstract: The process of discovering new drugs has been extremely costly and slow in the last decades despite enormous investment in pharmaceutical research. Drug repurposing enables researchers to speed up the process of discovering other conditions that existing drugs can effectively treat, with low cost and fast FDA approval. Here, we introduce 'RE:fine Drugs', a freely available interactive website for integrated search and discovery of drug repurposing candidates from GWAS and PheWAS repurposing datasets constructed using previously reported methods in Nature Biotechnology. 'RE:fine Drugs' demonstrates the possibilities to identify and prioritize novelty of candidates for drug repurposing based on the theory of transitive Drug-Gene-Disease triads. This public website provides a starting point for research, industry, clinical and regulatory communities to accelerate the investigation and validation of new therapeutic use of old drugs.Database URL: http://drug-repurposing.nationwidechildrens.org.
authors.affiliation: Research Information Solutions and Innovation, The Research Institute at Nationwide Children's Hospital Columbus, OH 43205, USA.
authors.forename: Soheil
authors.initials: S
authors.lastname: Moosavinasab
authors.affiliation: Research Information Solutions and Innovation, The Research Institute at Nationwide Children's Hospital Columbus, OH 43205, USA.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Patterson
authors.affiliation: Research Information Solutions and Innovation, The Research Institute at Nationwide Children's Hospital Columbus, OH 43205, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Strouse
authors.affiliation: Division of Biomedical Statistics & Informatics, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Majid
authors.initials: M
authors.lastname: Rastegar-Mojarad
authors.affiliation: Department of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
authors.forename: Kelly
authors.initials: K
authors.lastname: Regan
authors.affiliation: Department of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
authors.forename: Philip R O
authors.initials: PR
authors.lastname: Payne
authors.affiliation: Research Information Solutions and Innovation, The Research Institute at Nationwide Children's Hospital Columbus, OH 43205, USA.
authors.forename: Yungui
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Research Information Solutions and Innovation, The Research Institute at Nationwide Children's Hospital Columbus, OH 43205, USA Simon.Lin@nationwidechildrens.org.
authors.forename: Simon M
authors.initials: SM
authors.lastname: Lin
mesh_terms: D019295:Computational Biology / Q000379:methods*; D062313:Databases, Pharmaceutical; D058492:Drug Repositioning; D004358:Drug Therapy; D006801:Humans; D014584:User-Computer Interface