title: Features of uropathogenic Escherichia coli able to invade a prostate cell line.
abstract: RWPE-1 normal prostate cells were tested as an experimental model for adhesion/invasion assays by genotypically and phenotypically characterized community uropathogenic strains of Escherichia coli (UPEC), a frequent cause of urinary tract infections (UTIs) and significant etiologic agent also in bacterial prostatitis. Adhesive ability and strong biofilm production was significantly associated with the bacterial invasive phenotype. Invasive strains derived mainly from male and pediatric patients. This study suggests that such a cell model could usefully integrate other available methods of urovirulence analysis, to deepen knowledge on the bacterial interaction with host cells.
authors.affiliation: Department of Public Health and Infectious Diseases, Microbiology Section, "Sapienza" University of Rome, Italy.
authors.forename: Catia
authors.initials: C
authors.lastname: Longhi
authors.affiliation: Department of Public Health and Infectious Diseases, Microbiology Section, "Sapienza" University of Rome, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Comanducci
authors.affiliation: Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine & Orthopedics, Unit of Histology and Medical Embryology, "Sapienza" University of Rome, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Riccioli
authors.affiliation: Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine & Orthopedics, Unit of Histology and Medical Embryology, "Sapienza" University of Rome, Italy.
authors.forename: Elio
authors.initials: E
authors.lastname: Ziparo
authors.affiliation: Department of Public Health and Infectious Diseases, Microbiology Section, "Sapienza" University of Rome, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Marazzato
authors.affiliation: Department of Public Health and Infectious Diseases, Microbiology Section, "Sapienza" University of Rome, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Aleandri
authors.affiliation: Department of Public Health and Infectious Diseases, Microbiology Section, "Sapienza" University of Rome, Italy.
authors.forename: Antonietta Lucia
authors.initials: AL
authors.lastname: Conte
authors.affiliation: Department of Public Health and Infectious Diseases, Microbiology Section, "Sapienza" University of Rome, Italy.
authors.forename: Maria Stefania
authors.initials: MS
authors.lastname: Lepanto
authors.affiliation: Department of Public Health and Infectious Diseases, Microbiology Section, "Sapienza" University of Rome, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Goldoni
authors.affiliation: Department of Public Health and Infectious Diseases, Microbiology Section, "Sapienza" University of Rome, Italy.
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Conte
mesh_terms: D000293:Adolescent; D000328:Adult; D001422:Bacterial Adhesion / Q000502:physiology; D002460:Cell Line; D004927:Escherichia coli Infections / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000166:cytology*; D014552:Urinary Tract Infections / Q000382:microbiology*; D056689:Uropathogenic Escherichia coli / Q000145:classification / Q000502:physiology*; D055815:Young Adult
keywords: UPEC; cell invasion; prostate; virulence genes