title: Severe Anemia and Helicobacter Pylori Infection in school age Children; A case reports.
abstract: BACKGROUND
  Iron-deficiency anemia is a widespread public health problem with major consequences for human health especially, children. However, in a fraction of patients an underlying cause is never found during routine investigation. Recent studies have suggested an association between Helicobacter pylori (H. Pylori) infection and iron-deficiency anemia.
  
  
  METHODS
  Here is reported four school aged children (two male, two female) with refractory severe iron-deficiency anemia associated H. Pylori gastritis. Mean age of the patients was 13.62 years old and they were admitted with chief complaints of abdominal, chest pain weakness, headache and respiratory distress. Mean hemoglobin level in patients was 6.2 g/dl with persistence to iron therapy. After the diagnosis and therapy of H. pylori infection, clinical complaints, hemoglobin level and iron profiles were being normal and they gained weight.
  
  
  CONCLUSIONS
  This study suggests screening of H. pylori infection and appropriate treatment in any case of refractory moderate to severe iron-deficiency anemia, especially with clinical manifestations of gastrointestinal tract in children.
authors.forename: Sh
authors.initials: Sh
authors.lastname: Gheibi
authors.forename: M
authors.initials: M
authors.lastname: Noroozi
authors.forename: S
authors.initials: S
authors.lastname: Hejazi
authors.forename: M
authors.initials: M
authors.lastname: Karamyyar
authors.forename: H
authors.initials: H
authors.lastname: Farrokh-Eslamlou
keywords: Helicobacter pylor; Iron deficiency; Severe Iron deficiency anemia