title: The Possible Role of Flavonoids in the Prevention of Diabetic Complications.
abstract: Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated with insulin resistance, impaired insulin signaling, β-cell dysfunction, abnormal glucose levels, altered lipid metabolism, sub-clinical inflammation and increased oxidative stress. These and other unknown mechanisms lead to micro- and macro-complications, such as neuropathy, retinopathy, nephropathy and cardiovascular disease. Based on several in vitro animal models and some human studies, flavonoids appear to play a role in many of the metabolic processes involved in type 2 diabetes mellitus. In this review, we seek to highlight the most recent papers focusing on the relationship between flavonoids and main diabetic complications.
authors.affiliation: Experimental Models in Clinical Pathology, INRCA-IRCCS National Institute, Ancona I-60127, Italy. r.testa@inrca.it.
authors.forename: Roberto
authors.initials: R
authors.lastname: Testa
authors.affiliation: Scientific Direction, INRCA-IRCCS National Institute, Ancona I-60127, Italy. a.bonfigli@inrca.it.
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Bonfigli
authors.affiliation: Department of Cardiovascular and Metabolic Diseases, IRCCS Multimedica, Sesto San Giovanni I-20099, Italy. stefano.genovese@multimedica.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Genovese
authors.affiliation: Insititut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), C/Rosselló, 149-153, 08036 Barcelona, Spain. vnigris@clinic.ub.es.
authors.forename: Valeria
authors.initials: V
authors.lastname: De Nigris
authors.affiliation: Department of Cardiovascular and Metabolic Diseases, IRCCS Multimedica, Sesto San Giovanni I-20099, Italy. aceriell@clinic.ub.es.|Insititut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), C/Rosselló, 149-153, 08036 Barcelona, Spain. aceriell@clinic.ub.es.|Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona 08036, Spain. aceriell@clinic.ub.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ceriello
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D048909:Diabetes Complications / Q000209:etiology / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D004032:Diet; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005419:Flavonoids; D007004:Hypoglycemic Agents
keywords: diabetic complications; flavonoids; type 2 diabetes mellitus