title: Superior mediastinal mature cystic teratoma with gastrointestinal adenocarcinoma transformation: Report of a case.
abstract: Presented herein is a case of mediastinal mature teratoma with adenocarcinomatous transformation predominantly composed of mucinous adenocarcinoma in a 25-year-old man. Disease progressed despite application of surgical removal, adjuvant radio- and chemotherapy. Further immunohistochemical stains indicated a gastrointestinal origin of the tumor. Consequently chemotherapy according to the FOLFIRI regimen was applied that resulted in good response. To our knowledge, this is the first report of a clinical remission from chemotherapy with the FOLFIRI regimen after comprehensive initial treatment with surgery, radio- and chemotherapy for a patient with teratoma with malignant transformation, highlighting the importance of choosing an appropriate chemotherapy regimen.
authors.affiliation: Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P.R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Lin
authors.affiliation: Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P.R. China.
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P.R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P.R. China.
authors.forename: Huijie
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P.R. China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Chang
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D002471:Cell Transformation, Neoplastic; D005770:Gastrointestinal Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology*; D013724:Teratoma / Q000473:pathology*
keywords: FOLFIRI chemotherapy regimen; germ cell tumors; teratoma with malignant transformation; whole exome sequencing