title: Vascular-targeted nanocarriers: design considerations and strategies for successful treatment of atherosclerosis and other vascular diseases.
abstract: Vascular-targeted nanocarriers are an attractive option for the treatment of a number of cardiovascular diseases, as they allow for more specific delivery and increased efficacy of many small molecule drugs. However, immune clearance, limited cellular uptake, and particle-cell dynamics in blood flow can hinder nanocarrier efficacy in many applications. This review aims to investigate successful strategies for the use of vascular-targeted nanocarriers in the treatment of cardiovascular diseases such as atherosclerosis. In particular, the review will highlight strategies employed for actively targeting the components of the atherosclerotic plaque, including endothelial cells, macrophages, and platelets and passive targeting via endothelial permeability, as well as design specifications (such as size, shape, and density) aimed at enhancing the ability of nanocarriers to reach the vascular wall. WIREs Nanomed Nanobiotechnol 2016, 8:909-926. doi: 10.1002/wnan.1414 For further resources related to this article, please visit the WIREs website.
authors.affiliation: Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Kelley
authors.affiliation: Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Hanieh
authors.initials: H
authors.lastname: Safari
authors.affiliation: Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Genesis
authors.initials: G
authors.lastname: Lopez-Cazares
authors.affiliation: Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA. lolaa@umich.edu.
authors.forename: Omolola
authors.initials: O
authors.lastname: Eniola-Adefeso
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy*; D004337:Drug Carriers / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D004337:Drug Carriers