title: Screening of a virtual mirror-image library of natural products.
abstract: We established a facile access to an unexplored mirror-image library of chiral natural product derivatives using d-protein technology. In this process, two chemical syntheses of mirror-image substances including a target protein and hit compound(s) allow the lead discovery from a virtual mirror-image library without the synthesis of numerous mirror-image compounds.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. soishi@pharm.kyoto-u.ac.jp nfujii@pharm.kyoto-u.ac.jp.
authors.forename: Taro
authors.initials: T
authors.lastname: Noguchi
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. soishi@pharm.kyoto-u.ac.jp nfujii@pharm.kyoto-u.ac.jp.
authors.forename: Shinya
authors.initials: S
authors.lastname: Oishi
authors.affiliation: RIKEN CSRS, Wako, Saitama 351-0198, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Honda
authors.affiliation: RIKEN CSRS, Wako, Saitama 351-0198, Japan.
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Kondoh
authors.affiliation: RIKEN CSRS, Wako, Saitama 351-0198, Japan.
authors.forename: Tamio
authors.initials: T
authors.lastname: Saito
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. soishi@pharm.kyoto-u.ac.jp nfujii@pharm.kyoto-u.ac.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ohno
authors.affiliation: RIKEN CSRS, Wako, Saitama 351-0198, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. soishi@pharm.kyoto-u.ac.jp nfujii@pharm.kyoto-u.ac.jp.
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Fujii
mesh_terms: D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D008958:Models, Molecular; D011487:Protein Conformation; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000494:pharmacology*; D013237:Stereoisomerism; D014584:User-Computer Interface
chemical_list: D001688:Biological Products; D054852:Small Molecule Libraries