title: The ins and outs of phosphosignalling in Plasmodium: Parasite regulation and host cell manipulation.
abstract: Signal transduction and kinomics have been rapidly expanding areas of investigation within the malaria research field. Here, we provide an overview of phosphosignalling pathways that operate in all stages of the Plasmodium life cycle. We review signalling pathways in the parasite itself, in the cells it invades, and in other cells of the vertebrate host with which it interacts. We also discuss the potential of these pathways as novel targets for antimalarial intervention.
authors.affiliation: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria 3800, Australia.
authors.forename: Teresa Gil
authors.initials: TG
authors.lastname: Carvalho
authors.affiliation: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria 3800, Australia.
authors.forename: Belinda
authors.initials: B
authors.lastname: Morahan
authors.affiliation: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria 3800, Australia.
authors.forename: Simona
authors.initials: S
authors.lastname: John von Freyend
authors.affiliation: Burnet Institute, Melbourne, Victoria 3004, Australia; The University of Melbourne, Department of Medicine, Melbourne, Victoria 3010, Australia; Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, Victoria 3010, Australia.
authors.forename: Philippe
authors.initials: P
authors.lastname: Boeuf
authors.affiliation: Vascular Immunology Unit, Department of Pathology, Sydney Medical School, University of Sydney, Camperdown, New South Wales 2050, Australia.
authors.forename: Georges
authors.initials: G
authors.lastname: Grau
authors.affiliation: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria 3800, Australia.
authors.forename: Jose
authors.initials: J
authors.lastname: Garcia-Bustos
authors.affiliation: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Victoria 3800, Australia. Electronic address: christian.doerig@monash.edu.
authors.forename: Christian
authors.initials: C
authors.lastname: Doerig
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions; D006801:Humans; D010766:Phosphorylation; D010961:Plasmodium / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D015800:Protozoan Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D015800:Protozoan Proteins
keywords: Malaria; Phosphorylation; Plasmodium; Protein kinase; Protein phosphatase; Signalling