title: [Food intolerances caused by enzyme defects and carbohydrate malassimiliations : Lactose intolerance and Co].
abstract: Apart from allergic conditions, carbohydrate malassimiliations (sugar metabolism disorders) are classified within the group of food intolerances. These dose-dependent, yet non-immunological reactions require gastroenterological or internal diagnosis following nutritional therapy. Intolerances to carbohydrates such as lactose (milk sugar) and fructose (fruit sugar) in addition to sugar alcohols (sorbitol, mannitol, lactitol etc.) have been gaining increasing attention in recent decades as they are the cause of a wide range of gastrointestinal symptoms. There are currently various options for both diagnosis and therapy that differ notably in terms of effort, costs, and efficiency. Nutritional change and patient education are the bases of therapy. Non-observance of the trigger will result in increasing complaints and possibly even more infections, e.g., diverticula, rectal disorders, bacterial miscolonization, bile acid malabsorption). For an optimal therapy, the following sugar metabolism disorders have to be differentiated: hypolactasia versus lactose maldigestion, fructose malabsorption versus fructose overload, combined lactose and fructose intolerance, and isolated adverse reactions against sorbitol.For the medical conditions listed above, a three- or four-stage treatment regimen is recommended. Extensive dietary restrictions with regard to the relevant sugar, except for lactose, should not be maintained over a longer period of time.
authors.affiliation: Allergologische Schwerpunktpraxis, Colonnaden 72, 20354, Hamburg, Deutschland. info@christianeschaefer.de.
authors.forename: Christiane
authors.initials: C
authors.lastname: Schäfer
mesh_terms: D002239:Carbohydrate Metabolism, Inborn Errors; D003937:Diagnosis, Differential; D004035:Diet Therapy / Q000379:methods*; D004798:Enzymes / Q000172:deficiency*; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D006801:Humans; D008286:Malabsorption Syndromes / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*
chemical_list: D004798:Enzymes
keywords: Carbohydrate malassimilation; Fructose malabsorption; Lactose intolerance; Sugar alcohols; Sugar metabolism disorders