title: Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: are they useful for predicting gestational diabetes mellitus during pregnancy?
abstract: OBJECTIVE
  We aimed to investigate whether the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) could be utilized to screen for gestational diabetes mellitus (GDM).
  
  
  METHODS
  NLR and PLR were assessed by retrospective analysis of 762 healthy and pregnant women with GDM. The patients were stratified into four groups, as follows: GDM (n=144), impaired glucose tolerance (n=76), only screen positive (n=238), and control (n=304).
  
  
  RESULTS
  The leukocyte, neutrophil, and lymphocyte counts were significantly higher in the study groups compared with the control group (P=0.001; P<0.01). There were no statistically significant differences between the groups with respect to the NLR and PLR (P>0.05).
  
  
  CONCLUSIONS
  We do not recommend that blood NLR and PLR can be used to screen for GDM. However, increase in the leukocyte count is an important marker for GDM as it provides evidence of subclinical inflammation.
authors.affiliation: Department of Obstetrics and Gynecology, Fatih Sultan Mehmet Research and Training Hospital, Istanbul, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Sargın
authors.affiliation: Department of Obstetrics and Gynecology, Fatih Sultan Mehmet Research and Training Hospital, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Yassa
authors.affiliation: Department of Obstetrics and Gynecology, Fatih Sultan Mehmet Research and Training Hospital, Istanbul, Turkey.
authors.forename: Bilge Dogan
authors.initials: BD
authors.lastname: Taymur
authors.affiliation: Department of Obstetrics and Gynecology, Fatih Sultan Mehmet Research and Training Hospital, Istanbul, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Celik
authors.affiliation: Department of Obstetrics and Gynecology, Fatih Sultan Mehmet Research and Training Hospital, Istanbul, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Ergun
authors.affiliation: Department of Obstetrics and Gynecology, Fatih Sultan Mehmet Research and Training Hospital, Istanbul, Turkey.
authors.forename: Niyazi
authors.initials: N
authors.lastname: Tug
keywords: inflammation; lymphocytes; neutrophils; platelets; pregnancy