title: Histopathological types in adult nephrotic syndrome.
abstract: In Bangladesh, there are very few studies about biopsy proven adult Nephrotic syndrome (NS) with histological types and their clinical findings. To determine the histological types of glomerulonephritis (GN) in adult NS and correlate them with the clinical presentations and biochemical parameters, we studied 100 biopsies in 87 patients who underwent ultrasonography- guided renal biopsy in Rangpur Medical College and Hospital from July 2010 to June 2012. The mean age of the patients was 32.8 ± 13.2 years; male was preponderance (72.4%) and most of the patients (67.8%) came from rural areas. Membranoproliferative GN (MPGN) was the most common underlying cause that was found in 32 (36.8%) patients followed by mesangial proliferative GN in 27 (31%) patients, membranous GN in 16 (18.4%) cases, minimal change disease in four (4.6%) patients, diffuse proliferative GN in four (4.6%) patients, focal segmental GN, and focal proliferative GN in two (2.4%) patients each. High proteinuria level was found in minimal change disease, which was 7.59 ± 0.24 g/24 h (mean ± standard deviation). The most common symptoms were oliguria (92%) and edema (86.2%) followed by hematuria (dark urine) (72.4%) and hypertension (35.6%). MPGN was the most common histological type of adult NS in Rangpur.
authors.affiliation: Department of Internal Medicine, Prime Medical College and Hospital, Rangpur, Bangladesh.
authors.forename: Md Ghulam
authors.initials: MG
authors.lastname: Yusuf
authors.affiliation: Department of Medicine, Rangpur Medical College, Rangpur, Bangladesh.
authors.forename: Bidhu Bhushan
authors.initials: BB
authors.lastname: Das
authors.affiliation: Department of Medicine, Rangpur Medical College, Rangpur, Bangladesh.
authors.forename: Amaresh Chandra
authors.initials: AC
authors.lastname: Shaha
authors.affiliation: Department of Medicine, Rangpur Medical College, Rangpur, Bangladesh.
authors.forename: Md Zakir
authors.initials: MZ
authors.lastname: Hossain
mesh_terms: D000328:Adult; D001459:Bangladesh / Q000453:epidemiology; D015331:Cohort Studies; D004487:Edema; D005260:Female; D006417:Hematuria; D006801:Humans; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000453:epidemiology* / Q000473:pathology* / Q000503:physiopathology*; D009846:Oliguria; D055815:Young Adult