title: Isolation, Structure Elucidation, Biosynthesis, and Synthesis of Antalid, a Secondary Metabolite from Polyangium species.
abstract: The isolation, structure elucidation, and synthesis of antalid (1), a novel secondary metabolite from Polyangium sp., is described herein. The structure elucidation of 1 was performed with the aid of mass spectrometry, high field NMR experiments, and crystal structure analysis. The absolute configuration of antalid was confirmed through the Mosher ester method and ultimately by total synthesis. In addition, the biosynthetic origin of this hybrid PKS-NRPS natural product was unraveled by the in silico analysis of its biosynthetic gene cluster.
authors.affiliation: Institute for Organic Chemistry, Leibniz Universität Hannover , Schneiderberg 1B, D-30167 Hannover, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Tautz
authors.affiliation: Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland University , Building E8.1, D-66123 Saarbrücken, Germany.
authors.forename: Judith
authors.initials: J
authors.lastname: Hoffmann
authors.affiliation: Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland University , Building E8.1, D-66123 Saarbrücken, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hoffmann
authors.affiliation: Helmholtz Centre for Infection Research (HZI) , Inhoffenstr. 7, D-38124 Braunschweig, Germany.
authors.forename: Heinrich
authors.initials: H
authors.lastname: Steinmetz
authors.affiliation: Helmholtz Centre for Infection Research (HZI) , Inhoffenstr. 7, D-38124 Braunschweig, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Washausen
authors.affiliation: Helmholtz Centre for Infection Research (HZI) , Inhoffenstr. 7, D-38124 Braunschweig, Germany.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Kunze
authors.affiliation: Institute for Inorganic Chemistry, Saarland University , Building B2.2, D-66123 Saarbrücken, Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Huch
authors.affiliation: Institute for Biostatistics, Leibniz Universität Hannover , Herrenhäuser Straße 2, D-30419 Hannover, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kitsche
authors.affiliation: Helmholtz Centre for Infection Research (HZI) , Inhoffenstr. 7, D-38124 Braunschweig, Germany.
authors.forename: Hans
authors.initials: H
authors.lastname: Reichenbach
authors.affiliation: Helmholtz Centre for Infection Research (HZI) , Inhoffenstr. 7, D-38124 Braunschweig, Germany.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Höfle
authors.affiliation: Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland University , Building E8.1, D-66123 Saarbrücken, Germany.
authors.forename: Rolf
authors.initials: R
authors.lastname: Müller
authors.affiliation: Institute for Organic Chemistry, Leibniz Universität Hannover , Schneiderberg 1B, D-30167 Hannover, Germany.|Helmholtz Centre for Infection Research (HZI) , Inhoffenstr. 7, D-38124 Braunschweig, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Kalesse