title: Acquired inhibitor to factor VIII: report of two unusual cases.
abstract: The present report describes two unusual cases of bleeding due to development of inhibitor against factor VIII. One of the patients was known to have severe haemophilia B (factor IX < 1%) and the other, a healthy male of 46 years, spontaneously started to bleed and was found to have developed inhibitors to factor VIII:C along with other autoantibodies. Development of inhibitors to coagulation factors is a serious clinical problem in de-veloped countries and is more so in developing countries where treatment options are often limited.
authors.affiliation: Dr J C Patel Haematology Department, 10th Floor, King Edward VII Memorial Hospital, Mumbai - 400 012, India,Institute of Immunohematology (ICMR), 13th Floor, KEM Hospital, Mumbai - 400 012, India.
authors.forename: A V
authors.initials: AV
authors.lastname: Pathare
authors.affiliation: Dr J C Patel Haematology Department, 10th Floor, King Edward VII Memorial Hospital, Mumbai - 400 012, India,Institute of Immunohematology (ICMR), 13th Floor, KEM Hospital, Mumbai - 400 012, India.
authors.forename: S
authors.initials: S
authors.lastname: Ghamande
authors.affiliation: Dr J C Patel Haematology Department, 10th Floor, King Edward VII Memorial Hospital, Mumbai - 400 012, India,Institute of Immunohematology (ICMR), 13th Floor, KEM Hospital, Mumbai - 400 012, India.
authors.forename: S
authors.initials: S
authors.lastname: Fernandes
authors.affiliation: Dr J C Patel Haematology Department, 10th Floor, King Edward VII Memorial Hospital, Mumbai - 400 012, India,Institute of Immunohematology (ICMR), 13th Floor, KEM Hospital, Mumbai - 400 012, India.
authors.forename: S
authors.initials: S
authors.lastname: Bhatia
authors.affiliation: Dr J C Patel Haematology Department, 10th Floor, King Edward VII Memorial Hospital, Mumbai - 400 012, India,Institute of Immunohematology (ICMR), 13th Floor, KEM Hospital, Mumbai - 400 012, India.
authors.forename: F
authors.initials: F
authors.lastname: Jijina
authors.affiliation: Dr J C Patel Haematology Department, 10th Floor, King Edward VII Memorial Hospital, Mumbai - 400 012, India,Institute of Immunohematology (ICMR), 13th Floor, KEM Hospital, Mumbai - 400 012, India.
authors.forename: S
authors.initials: S
authors.lastname: Shetty
authors.affiliation: Dr J C Patel Haematology Department, 10th Floor, King Edward VII Memorial Hospital, Mumbai - 400 012, India,Institute of Immunohematology (ICMR), 13th Floor, KEM Hospital, Mumbai - 400 012, India.
authors.forename: K
authors.initials: K
authors.lastname: Ghosh
authors.affiliation: Dr J C Patel Haematology Department, 10th Floor, King Edward VII Memorial Hospital, Mumbai - 400 012, India,Institute of Immunohematology (ICMR), 13th Floor, KEM Hospital, Mumbai - 400 012, India.
authors.forename: D
authors.initials: D
authors.lastname: Mohanty
keywords: acquired haemophilia; autoantibodies; factor VIII inhibitors