title: Male sex may be associated with higher metabolic risk in first-episode schizophrenia patients: A preliminary study.
abstract: BACKGROUND
  High incidence of metabolic syndrome has been evidenced in schizophrenia patients. However, gender-specific relationship with risk of metabolic disorders in first-episode schizophrenia has received poor systematic study.
  
  
  OBJECTIVE
  We aimed at exploring the impact of sex difference on the parameters of glucolipid metabolism in first-episode psychosis schizophrenia (FEP) patients.
  
  
  METHODS
  We performed a post hoc analysis of data from our previously performed clinical trial. A total of 60 FEP patients and 28 healthy sex- and age-matched volunteers were included. Blood glucose and lipid metabolic profiles, as well as schizophrenia-related clinical symptoms were assessed. The body mass index, level of blood insulin and the homeostasis model assessment-insulin resistance index (HOMA-IR) were measured.
  
  
  RESULTS
  The FEP patients demonstrated significant increases in blood insulin concentration, insulin resistance and blood triglyceride when compared with healthy controls. In FEP patients, there were no differences in psychopathology measurements between the genders. BMI and HOMA-IR were significantly greater in male vs female FEP patients. In addition, a more severe dyslipidemia was also observed in male FEP patients, including an increased triglyceride level, an augmented LDL content and a decreased HDL concentration. Multivariate linear regression analysis demonstrated that the gender was significantly correlated to HOMA-IR.
  
  
  CONCLUSIONS
  These preliminary results suggest that male FEP patients may be more predisposed to insulin resistance and dyslipidemia than female FEP patients. These results could contribute to the understanding of prevention and treatment of metabolic syndrome in FEP patients.
authors.affiliation: Center for Biological Psychiatry, Beijing HuiLongGuan Hospital, Changping District, Beijing, PR China.
authors.forename: Song
authors.initials: S
authors.lastname: Chen
authors.affiliation: Center for Biological Psychiatry, Beijing HuiLongGuan Hospital, Changping District, Beijing, PR China.
authors.forename: Dong
authors.initials: D
authors.lastname: Broqueres-You
authors.affiliation: Center for Biological Psychiatry, Beijing HuiLongGuan Hospital, Changping District, Beijing, PR China.
authors.forename: Guigang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Center for Biological Psychiatry, Beijing HuiLongGuan Hospital, Changping District, Beijing, PR China.
authors.forename: Zhiren
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Center for Biological Psychiatry, Beijing HuiLongGuan Hospital, Changping District, Beijing, PR China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Li
authors.affiliation: Center for Biological Psychiatry, Beijing HuiLongGuan Hospital, Changping District, Beijing, PR China. Electronic address: yangfd200@126.com.
authors.forename: Fude
authors.initials: F
authors.lastname: Yang
authors.affiliation: Center for Biological Psychiatry, Beijing HuiLongGuan Hospital, Changping District, Beijing, PR China. Electronic address: yltan21@126.com.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Tan
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D015897:Comorbidity; D050171:Dyslipidemias / Q000453:epidemiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D012559:Schizophrenia / Q000453:epidemiology / Q000378:metabolism*; D012737:Sex Factors; D055815:Young Adult
keywords: Dyslipidemia; First-episode schizophrenia; Insulin resistance; Male