title: Templated assembly of medium cyclic ethers via exo-trig nucleophilic cyclization of cyclopropenes.
abstract: A novel method for the assembly of medium heterocycles via an intramolecular nucleophilic addition to cyclopropenes generated in situ from the corresponding bromocyclopropanes is described. The exo-trig nucleophilic cyclizations were shown to proceed very efficiently and in a highly diastereoselective fashion affording cis-fused bicyclic products possessing 7 to 10-membered medium rings; starting from a diastereomeric mixtures of bromocyclopropanes.
authors.affiliation: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Dr., Lawrence, KS 66045-7582, USA. mrubin@ku.edu.
authors.forename: Bassam K
authors.initials: BK
authors.lastname: Alnasleh
authors.forename: Marina
authors.initials: M
authors.lastname: Rubina
authors.forename: Michael
authors.initials: M
authors.lastname: Rubin