title: [Hepatitis B virus genotypes and evolutionary markers in chronic HBsAG patients in Bujumbura].
abstract: BACKGROUND
  Hepatitis B virus infection (VHB) is a serious condition which can lead to serious complications, such as cirrhosis and hepato-cellular carcinoma (HCC). HBV genotypes greatly influence its evolution and the effectiveness of treatment. The aim was to evaluate the HBV genotypes and the evolutionary pathways of chronic HBsAG patients.
  
  
  METHODS
  A cross-sectional study was conducted at the University Hospital of Kamenge and at the Digestive and liver diseases Center "CEMADIF" between June 2013 and Mai 2014. Genotyping, quantitative assay of HBeAG and HBV DNA levels were determined in the CERBA Laboratory Cergy Pontoise, France. Fibrotest or Fibroscan were used to evaluate fibrosis.
  
  
  RESULTS
  In total 33 patients (52,4% were males, median age 38,1) were enrolled. According to evolutionary markers, 112 patients (78,3%) had negative HBeAG. As regards the viral load, 106 patients (74,2%) had viremia lower than 2000UI/ml and minimal fibrosis below 7 kPa according FibroScan. Of these, 13 patients had undetectable HBV DNA (<20UI/ml). The others 37 patients (26,8%) had a viral load higher than 2000UI/ml and, among them, 31 were HBeAg positive(>0,8UI/ml). It was possible to determine genotype in 51 patients who had a high enough viremia to technically enable dosing. These patients had genotype A.
  
  
  CONCLUSIONS
  HBV genotype-A is the most common in Bujumbura. It is associated with HBV inactive carries.
authors.affiliation: Centre Hospitalo-Universitaire de Kamenge, Bujumbura, Burundi; Centre des maladies digestives et du Foie, Bujumbura, Burundi.
authors.forename: Rénovat
authors.initials: R
authors.lastname: Ntagirabiri
authors.affiliation: Centre des maladies digestives et du Foie, Bujumbura, Burundi.
authors.forename: Belyse
authors.initials: B
authors.lastname: Munezero
authors.affiliation: Centre Hospitalo-Universitaire de Kamenge, Bujumbura, Burundi.
authors.forename: Caritas
authors.initials: C
authors.lastname: Nahimana
authors.affiliation: Centre Hospitalo-Universitaire de Kamenge, Bujumbura, Burundi.
authors.forename: Evariste
authors.initials: E
authors.lastname: Ndabaneze
mesh_terms: D000328:Adult; D002063:Burundi / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004279:DNA, Viral; D005260:Female; D005838:Genotype; D006514:Hepatitis B Surface Antigens / Q000235:genetics; D006513:Hepatitis B e Antigens / Q000235:genetics*; D006515:Hepatitis B virus / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D008297:Male; D019562:Viral Load; D014766:Viremia / Q000821:virology
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens
keywords: HBeAG; HBsAG; Hepatitis B Virus; Hepatitis B virus (HBV) genotype