title: Diffuse Large B-Cell Lymphoma of Maxilla - A Case Report of Late Relapse.
abstract: Diffuse Large B Cell Lymphomas (DLBCL) encompasses a heterogeneous group of tumors that together constitute the commonest of all Non Hodgkin Lymphoma (NHL) and the proclivity of DLBCL to oral cavity is unknown. They mostly arise from soft tissues as asymptomatic lesions, mostly without 'B' symptoms and involvement of jaw bones is uncommon. Most studies and case reports of oral DLBCL's are based on, manifestation of primary extra-nodal disease or a component of a disseminated disease process involving regional lymph nodes. Many investigators have proposed that patients with this cell type who maintain a complete response for 24 consecutive months are cured because late relapses seldom occur. With advances in treatment modalities, many patients with NHL become long-term survivors and the risk of relapses or second tumors are of growing concern. We present a case of DLBCL which relapsed after five years of initial lesion in a 41 year old female patient and presented as a nonspecific bilateral anterior maxillary radiolucency. DLBCL usually express pan-B markers with small percentage expressing T-cell markers. Few rare cases of DLBCL have shown CD3 expression, which is a most sensitive T-cell marker which was focally expressed in the present case.
authors.affiliation: Professor and Head of Deparment, Department of Oral and Maxillofacial Surgery, Meghana Institute of Dental Sciences , Nizamabad, Telangana, India .
authors.forename: Medikonda Suresh
authors.initials: MS
authors.lastname: Kumar
authors.affiliation: Professor, Department of Oral Maxillofacial Pathology and Microbiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre , Hyderabad, Telangana, India .
authors.forename: Ashalata
authors.initials: A
authors.lastname: Gannepalli
authors.affiliation: Post-graduate Student, Department of Oral Maxillofacial Pathology and Microbiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre , Hyderabad, Telangana, India .
authors.forename: Anuradha
authors.initials: A
authors.lastname: Chandragiri
authors.affiliation: Reader, Department of Oral and Maxillofacial Surgery, Meghana Institute of Dental Sciences , Nizamabad, Telangana, India .
authors.forename: Konda
authors.initials: K
authors.lastname: Amarnath
keywords: Immunohistochemistry; Intrabony; Non-Hodgkin’s lymphoma; Radiolucency; Swelling