title: Effect of Addition of Platelet-rich Plasma to Calcium Phosphosilicate Putty on Healing at 9 Months in Periodontal Intrabony Defects.
abstract: OBJECTIVE
  Combination of platelet-rich plasma (PRP) and bone substitutes for the surgical treatment of periodontal intrabony defects is based on a sound biologic rationale; however, the clinical results indicative of the synergistic effect of PRP remain ambiguous. The objective of the present study was to clinically and radiographically evaluate the use of calcium phosphosilicate (CPS) putty alone and in combination with PRP in the treatment of periodontal intrabony defects.
  
  
  METHODS
  The study was performed at an outpatient facility at a teaching dental institute in north India. A split-mouth design was employed to assess the clinical parameters and radiographic bone fill following the use of CPS putty with and without PRP in patients scheduled for surgical periodontal treatment of intrabony osseous defects. Each defect was randomized to receive treatment with open flap debridement, with CPS putty alone (Group PUT), or open flap debridement with CPS putty and PRP (Group PRp). Probing pocket depth (PPD), plaque index (PI), gingival index (GI), and clinical attachment levels (CALs) were recorded at the investigated sites utilizing custom-made reference guides for measurement reproducibility. Standardized periapical radiographs were also obtained to evaluate defect fill at the surgical sites.
  
  
  RESULTS
  Twenty patients each with at least two defects located in different quadrants were enrolled. The reduction in PPD from baseline to 1st, 3rd, 6th, and 9th month was found to be significant (p < 0.05). The percent reduction in PPD among PUT group was 57.18 ± 10.71% and among PRP group was 51.39 ± 12.60%. No statistically significant difference was observed in the percent reduction in PPD among two groups at 9 months (p = 0.48). Sites in both groups exhibited statistically significant reductions in PI and GI that were maintained throughout the study period. Similar results were seen while measuring CAL.
  
  
  CONCLUSIONS
  Calcium phosphosilicate Putty alone provides significant improvement in outcomes for the treatment of periodontal intraosseous defects. The addition of PRP to CPS putty does not seem to provide any additive benefit to treatment and the additional surgical time and trauma can be avoided.
authors.affiliation: Faculty, Department of Periodontology, Seema Dental College and Hospital, Rishikesh, Uttarakhand, c-488 SFS Flats, Sheikh Sarai Phase - I, New Delhi -110017, India Phone: +91-9873090671, e-mail: Shukla.sagrika@gmail.com.
authors.forename: Sagrika
authors.initials: S
authors.lastname: Shukla
authors.affiliation: Department of Dentistry and Oral and Maxillofacial Surgery All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
authors.forename: Ashi
authors.initials: A
authors.lastname: Chug
authors.affiliation: Private Practice, The Specialist Clinic, Saket, New Delhi, India.
authors.forename: Lanka
authors.initials: L
authors.lastname: Mahesh
authors.affiliation: Department of Periodontology, Faculty and Dental Sciences SGT Dental College and Hospital, SGT University, Gurgaon Haryana, India.
authors.forename: Harpreet Singh
authors.initials: HS
authors.lastname: Grover
mesh_terms: D000328:Adult; D018786:Bone Substitutes; D017610:Calcium Compounds; D005260:Female; D006801:Humans; D008297:Male; D053657:Platelet-Rich Plasma; D017640:Silicates; D014945:Wound Healing / Q000502:physiology*
chemical_list: D018786:Bone Substitutes; D017610:Calcium Compounds; D017640:Silicates; C031293:calcium silicate
keywords: Intrabony defects; Novabone® bone graft; Platelet-rich plasma (PRP); Regeneration.