title: Antibiotic-Resistant Infections and Treatment Challenges in the Immunocompromised Host.
abstract: This article reviews antibiotic resistance and treatment of bacterial infections in the growing number of patients who are immunocompromised: solid organ transplant recipients, the neutropenic host, and persons with human immunodeficiency virus and AIDS. Specific mechanisms of resistance in both gram-negative and gram-positive bacteria, as well as newer treatment options are addressed elsewhere, and are only briefly discussed in the context of the immunocompromised host.
authors.affiliation: Akron General Medical Center, 1 Akron General Way, Akron, OH 44302, USA; Northeast Ohio Medical University, 4209 St. Rt. 44, PO Box 95, Rootstown, Ohio 44272, USA. Electronic address: donald.dumford@akrongeneral.org.
authors.forename: Donald M
authors.initials: DM
authors.lastname: Dumford
authors.affiliation: Louis Stokes Cleveland Department of Veterans Affairs, 10701 East Blvd 111(W), Cleveland, OH 44106, USA; Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106, USA.
authors.forename: Marion
authors.initials: M
authors.lastname: Skalweit
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects / Q000472:pathogenicity; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D015658:HIV Infections; D006801:Humans; D016867:Immunocompromised Host; D066027:Transplant Recipients
chemical_list: D000900:Anti-Bacterial Agents
keywords: HIV/AIDS; Immunocompromise; Infection; MDRO; Organ transplant recipients