title: Peroxiredoxin 6 is a natural radioprotector.
abstract: After injection of 20 mg/kg peroxiredoxin 6 to male Kv:SHK mice 15 min before X-ray irradiation in the range of lethal doses (7-10 Gy), the mice remained alive for 30 days, whereas the mortality of the control animals was 100%. In the irradiated animals, peroxiredoxin 6 decreased the severity of radiation-induced leucopenia, granulocytopenia, and thrombocytopenia, increased the number of blood corpuscles, and prevented the mass death of epithelial cells and the destruction of the small intestine. Thus, peroxiredoxin 6 can be regarded as a prophylactic radioprotective agent.
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia. sharapov.mars@gmail.com.
authors.forename: M G
authors.initials: MG
authors.lastname: Sharapov
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, pr. Nauki 3, Pushchino, Moscow oblast, 142290, Russia.|Prokhorov Institute of General Physics, Russian Academy of Sciences, ul. Vavilova 38, Moscow, 119991, Russia.|Pushchino State Natural Science Institute, Pushchino, Moscow oblast, 142290, Russia.|Lobachevskii Nizhny Novgorod State University, Nizhny Novgorod, 603600, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Gudkov
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia.|Pushchino State Natural Science Institute, Pushchino, Moscow oblast, 142290, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Gordeeva
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, pr. Nauki 3, Pushchino, Moscow oblast, 142290, Russia.
authors.forename: O E
authors.initials: OE
authors.lastname: Karp
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, pr. Nauki 3, Pushchino, Moscow oblast, 142290, Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Ivanov
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, pr. Nauki 3, Pushchino, Moscow oblast, 142290, Russia.|Pushchino State Natural Science Institute, Pushchino, Moscow oblast, 142290, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Shelkovskaya
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, pr. Nauki 3, Pushchino, Moscow oblast, 142290, Russia.|Pushchino State Natural Science Institute, Pushchino, Moscow oblast, 142290, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Bruskov
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia.|Pushchino State Natural Science Institute, Pushchino, Moscow oblast, 142290, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Novoselov
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia.
authors.forename: E E
authors.initials: EE
authors.lastname: Fesenko
mesh_terms: D000818:Animals; D007275:Injections, Intravenous; D007421:Intestine, Small / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D008297:Male; D051379:Mice; D054465:Peroxiredoxin VI / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000473:pathology; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D012720:Severity of Illness Index; D016019:Survival Analysis; D014965:X-Rays
chemical_list: D011837:Radiation-Protective Agents; D054465:Peroxiredoxin VI