title: Injecting Hope--A Review of Breast Cancer Vaccines.
abstract: There is significant interest in investigating immunotherapeutic strategies to be used for the treatment of breast cancer patients. One form of immunotherapy under active investigation is the cancer vaccine. Vaccines are a form of active immune therapy designed to stimulate the immune system to recognize tumor cells as foreign. Vaccines include an antigen that serves as the target for the immune response, and an immunoadjuvant, which is a nonspecific stimulator of the immune response that promotes an environment conducive to immune stimulation. Vaccines are an appealing therapeutic strategy because they are specific and are associated with minimal toxicity. In addition, they stimulate the adaptive immune system, thereby producing a memory response allowing for sustained effect without repeated therapy. Currently, there are no US Food and Drug Administration-approved breast cancer vaccines; however, there are multiple vaccines and treatment strategies employing these vaccines that are being actively investigated in clinical trials.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Mittendorf
authors.forename: George E
authors.initials: GE
authors.lastname: Peoples
mesh_terms: D056704:Adaptive Immunity; D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D001943:Breast Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D019496:Cancer Vaccines / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D007167:Immunotherapy / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome; D019139:Tumor Escape; D059016:Tumor Microenvironment
chemical_list: D000276:Adjuvants, Immunologic; D019496:Cancer Vaccines