title: The Edinburgh Cognitive and Behavioural ALS Screen in a Chinese Amyotrophic Lateral Sclerosis Population.
abstract: The existing screening batteries assessing multiple neuropsychological functions are not specific to amyotrophic lateral sclerosis (ALS) patients and are limited to their physical dysfunctions, whereas category cognitive tests are too time-consuming to assess all the domains. The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) was recently developed as a fast and easy cognitive screening tool specifically designed for patients. The purpose of the study was to validate the effectiveness of the Chinese version in Chinese ALS populations.
  
  
  
  Eighty-four ALS patients and 84 age-, gender- and education-matched healthy controls were included in this cross-sectional study. All the participants took the ECAS, Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB). Primary caregivers of patients were interviewed for behavioural and psychiatric changes.
  
  
  
  Significant differences were noted in language (p = 0.01), fluency, executive function, ALS-specific functions, and ECAS total score (p<0.01) between ALS patients and controls. The cut-off value of the total ECAS score was 81.92. Cognitive impairment was observed in 35.71% of patients, and 27.38% exhibited behavioural abnormalities. The ECAS total score had a medium correlation with education year. Memory was more easily impaired in the lower education group, whereas verbal fluency and language function tended to be preserved in the higher education group. The average time of ECAS was only 18 minutes.
  
  
  
  The Chinese version of the ECAS is the first screening battery assessing multiple neuropsychological functions specially designed for the ALS population in China, which provides an effective and rapid tool to screen cognitive and behavioural impairments.
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Ye
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ji
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing, China.
authors.forename: Chengyu
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing, China.
authors.forename: Ji
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing, China.
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Fan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis* / Q000208:ethnology*; D044466:Asian People; D001519:Behavior; D017028:Caregivers; D016022:Case-Control Studies; D002681:China; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis; D003430:Cross-Sectional Studies; D056344:Executive Function; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D011594:Psychometrics / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity