title: Division of labor in the growth cone by DSCR1.
abstract: Local protein synthesis directs growth cone turning of nascent axons, but mechanisms governing this process within compact, largely autonomous microenvironments remain poorly understood. In this issue, Wang et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201510107) demonstrate that the calcineurin regulator Down syndrome critical region 1 protein modulates both basal neurite outgrowth and growth cone turning.
authors.affiliation: Department of Neuroscience, University of Wisconsin, Madison, WI 53706 Cell and Molecular Biology Training Program, University of Wisconsin, Madison, WI 53706.
authors.forename: Timothy S
authors.initials: TS
authors.lastname: Catlett
authors.affiliation: Department of Neuroscience, University of Wisconsin, Madison, WI 53706 Cell and Molecular Biology Training Program, University of Wisconsin, Madison, WI 53706 tmgomez@wisc.edu.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Gomez
mesh_terms: D019703:Calcineurin / Q000378:metabolism; D002478:Cells, Cultured; D004268:DNA-Binding Proteins; D020439:Growth Cones / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D009124:Muscle Proteins / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009124:Muscle Proteins; C108612:RCAN1 protein, human; D019703:Calcineurin