title: [ASSOCIATION BETWEEN FOUR SEROTONIC GENES POLYMORPHISM (5HTTL, 5HT1A, 5HT2A, AND MAOA) AND PERSONALITY TRAITS IN WRESTLERS AND CONTROL GROUP].
abstract: This study presents the data on the polymorphisms of the serotonin system genes (5-HTTL, 5-HT1A, 5-HT2A, and MAOA) in male and female wrestlers and in the control group. The population genetics analysis of the 5HTTL gene showed the highest frequency of the SS genotype 5-HTTLPR in sportsmen (p = 0.04), as well as the trend toward higher frequency of united genotypes of the locus of 5-HTTLPR VNTR and SNP rs25531--SASA (p = 0.06) in comparison with the control group. As for the polymorphisms for other genes 5-HT1A (rs6295), 5-HT2A (rs6311), and MAOA (VNTR), we found no significant differences between the groups tested. Using the NEO PI-R questionnaire we analyzed the possible correlations between the genotypes and the psychological traits in our samples. It was demonstrated that the athletic success in elite sportsmen was associated with lower openness to experience and higher conscientiousness. The interaction effect of the gender and 5-HT2A on the self-rating for openness to experience, interaction effect of the level of the sport success and 5-HT2A, and the interaction effect of the gender and 5-HT1A genotype on self-reported conscientiousness were observed as a trend.
authors.forename: P R
authors.initials: PR
authors.lastname: Butovskaya
authors.forename: O E
authors.initials: OE
authors.lastname: Lazebnij
authors.forename: D I
authors.initials: DI
authors.lastname: Fekhretdionva
authors.forename: V A
authors.initials: VA
authors.lastname: Vasil'ev
authors.forename: E A
authors.initials: EA
authors.lastname: Prosikova
authors.forename: V V
authors.initials: VV
authors.lastname: Lysenko
authors.forename: I G
authors.initials: IG
authors.lastname: Udina
authors.forename: M L
authors.initials: ML
authors.lastname: Butovskaya
mesh_terms: D056352:Athletes / Q000523:psychology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats; D008995:Monoamine Oxidase / Q000235:genetics*; D010551:Personality / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012737:Sex Factors; D014952:Wrestling / Q000523:psychology*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D044282:Receptor, Serotonin, 5-HT1A; D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human