title: Do Intron and Coding Sequences of Some Human-Mouse Orthologs Evolve as a Single Unit?
abstract: It has been previously suggested that both the coding and the associated non-coding sequences of some human-mouse orthologs could evolve as a single unit. This letter deals with the observation that between mouse and humans some orthologs change significantly their compositional features as an indication that the molecular evolution is a local process. Moreover, the data shown indicate that the coding and the intron sequences of these orthologs do not evolve independently but instead both undergo a concerted evolution, evolving as a single unit, from a compositional cluster in mouse to a different compositional cluster in human.
authors.affiliation: Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Universidad Autónoma de Madrid, c/Nicolás Cabrera 1, 28049, Madrid, Spain. mafuertes@cbm.csic.es.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Fuertes
authors.affiliation: Telefónica de España S.A., Gran Vía, 28, Madrid, Spain.
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Rodrigo
authors.affiliation: Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Universidad Autónoma de Madrid, c/Nicolás Cabrera 1, 28049, Madrid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Alonso
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence / Q000235:genetics; D005075:Biological Evolution; D019143:Evolution, Molecular; D005091:Exons; D015894:Genome, Human; D006801:Humans; D007438:Introns; D051379:Mice; D005810:Multigene Family; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
keywords: Co-evolution; Gene clustering; Molecular evolution; Triplet composon