title: Systemic inflammatory markers as prognostic factors in stage IIA colorectal cancer.
abstract: BACKGROUND
  The aim of this study was to evaluate systemic inflammatory markers as prognostic factors in patients with stage IIA colorectal cancer.
  
  
  METHODS
  Among the patients who underwent curative resection for colorectal cancer at Seoul National University Hospital between 2002 and 2010, 1,035 who were classified as postoperative pathologic stage IIA (T3N0M0) were included. Systemic inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI), and serum fibrinogen level, were retrospectively reviewed. The patients were divided into two groups according to the cut-off values of the systemic inflammatory markers after receiver operating characteristic (ROC) curve analysis. Survival analysis was performed to identify factors associated with disease-free survival (DFS) and overall survival (OS).
  
  
  RESULTS
  Age, American Society of Anesthesiologists (ASA) score, tumor location, number of harvested lymph nodes, venous invasion, perineural invasion, adjuvant treatment and PNI (HR = 1.534, 95%CI: 1.065-2.211, P = 0.022; HR = 1.915, 95%CI: 1.286-2.852, P = 0.001 for DFS and OS, respectively) were independent significant prognostic factors for both DFS and OS.
  
  
  CONCLUSIONS
  PNI can be a prognostic marker in stage IIA colorectal cancer. J. Surg. Oncol. 2016;114:216-221. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Byung Kwan
authors.initials: BK
authors.lastname: Park
authors.affiliation: Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.|Cancer Research Institute, Seoul National University, Seoul, Korea.|Colorectal Cancer Center, Seoul National University Cancer Hospital, Seoul, Korea.
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Park
authors.affiliation: Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Eon Chul
authors.initials: EC
authors.lastname: Han
authors.affiliation: Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Seung-Bum
authors.initials: SB
authors.lastname: Ryoo
authors.affiliation: Cancer Research Institute, Seoul National University, Seoul, Korea.|Colorectal Cancer Center, Seoul National University Cancer Hospital, Seoul, Korea.|Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Sae-Won
authors.initials: SW
authors.lastname: Han
authors.affiliation: Cancer Research Institute, Seoul National University, Seoul, Korea.|Colorectal Cancer Center, Seoul National University Cancer Hospital, Seoul, Korea.|Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Tae-You
authors.initials: TY
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Eui Kyu
authors.initials: EK
authors.lastname: Chie
authors.affiliation: Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.|Cancer Research Institute, Seoul National University, Seoul, Korea.|Colorectal Cancer Center, Seoul National University Cancer Hospital, Seoul, Korea.
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Jeong
authors.affiliation: Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.|Colorectal Cancer Center, Seoul National University Cancer Hospital, Seoul, Korea.
authors.forename: Kyu Joo
authors.initials: KJ
authors.lastname: Park
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000401:mortality*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015596:Nutrition Assessment; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers
keywords: colonic neoplasm; inflammation; prognostic nutritional index