title: Detecting and Managing Adverse Effects of Antipsychotic Medications: Current State of Play.
abstract: Antipsychotics are some of the most frequently prescribed medications not only for psychotic disorders and symptoms but also for a wide range of on-label and off-label indications. Because second-generation antipsychotics have largely replaced first-generation antipsychotics as first-line options due to their substantially decreased risk of extrapyramidal side effects, attention has shifted to other clinically concerning adverse events associated with antipsychotic therapy. The focus of this article is to update the nonextrapyramidal side effects associated with second-generation antipsychotics. Issues surrounding diagnosis and monitoring as well as clinical management are addressed.
authors.affiliation: Department of Psychiatry, Psychosocial Rehabilitation and Recovery Center, West Los Angeles Veterans Affairs Medical Center, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA; David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA. Electronic address: Donna.ames@va.gov.
authors.forename: Donna
authors.initials: D
authors.lastname: Ames
authors.affiliation: Pharmacy Service, Veterans Affairs Northern California Health Care System, 10535 Hospital Way, Mather, CA 95655, USA; Department of Pharmacy Practice, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211, USA.
authors.forename: Sian M
authors.initials: SM
authors.lastname: Carr-Lopez
authors.affiliation: Chapman University School of Pharmacy, 9401 Jeronimo Road, Irvine, CA 92618, USA.
authors.forename: Mary A
authors.initials: MA
authors.lastname: Gutierrez
authors.affiliation: Schizophrenia Treatment Unit, West Los Angeles VA Medical Center, Los Angeles, CA 90073, USA; Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Pierre
authors.affiliation: Department of Pharmacy, Veterans Affairs Northern California Healthcare System, 150 Muir Road, Martinez, CA 94553, USA; University of the Pacific School of Pharmacy, 3601 Pacific Avenue, Stockton, CA 95211, USA; University of Southern California School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA 90089, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Rosen
authors.affiliation: Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific 3601 Pacific Avenue, Stockton, CA 95211, USA; Department of Pharmacy, Veterans Affairs Long Beach Healthcare System, 5901 East 7th Street, Long Beach, CA 90822, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Shakib
authors.affiliation: Semel Institute for Neuroscience & Human Behavior, UCLA, 760 Westwood Plaza, Suite C8-193, Los Angeles, CA 90024, USA.
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Yudofsky
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D003704:Dementia / Q000150:complications / Q000188:drug therapy; D019468:Disease Management; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced / Q000150:complications; D006966:Hyperprolactinemia / Q000139:chemically induced / Q000150:complications / Q000453:epidemiology; D008133:Long QT Syndrome / Q000139:chemically induced / Q000150:complications; D010024:Osteoporosis / Q000139:chemically induced / Q000150:complications; D011618:Psychotic Disorders / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D012307:Risk Factors; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced / Q000150:complications / Q000453:epidemiology; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced / Q000150:complications / Q000453:epidemiology; D015430:Weight Gain
chemical_list: D014150:Antipsychotic Agents
keywords: Adverse effects; Antipsychotic medication; First-generation antipsychotics; Hyperlipidemia; Hyperprolactinemia; QT prolongation; Second-generation antipsychotics; Weight gain