title: Lysosomal Acid Lipase Activity Is Reduced Both in Cryptogenic Cirrhosis and in Cirrhosis of Known Etiology.
abstract: Liver cirrhosis is characterized by a severe acquired reduction of LAL-activity, the precise causes and consequences of which need to be further addressed. DBS-determined lysosomal enzyme activities seem to be affected by white blood cell and platelet counts, and the specificity of these tests can be reduced when applied to determined populations, such as cirrhotics.
authors.affiliation: Internal Medicine and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Vespasiani-Gentilucci
authors.affiliation: Internal Medicine and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Gallo
authors.affiliation: Unit of Neuromuscolar and Neurodegenerative Diseases, Children's Hospital and Research Institute "Bambino Gesù", Rome, Italy.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Piemonte
authors.affiliation: Virology Unit, University Campus Bio-Medico, Rome, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Riva
authors.affiliation: Internal Medicine and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.
authors.forename: Aldostefano
authors.initials: A
authors.lastname: Porcari
authors.affiliation: Internal Medicine and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.
authors.forename: Ferruccio
authors.initials: F
authors.lastname: Vorini
authors.affiliation: Unit of Neuromuscolar and Neurodegenerative Diseases, Children's Hospital and Research Institute "Bambino Gesù", Rome, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Tozzi
authors.affiliation: Virology Unit, University Campus Bio-Medico, Rome, Italy.
authors.forename: Livia
authors.initials: L
authors.lastname: Piccioni
authors.affiliation: Internal Medicine and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Galati
authors.affiliation: Internal Medicine and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: De Vincentis
authors.affiliation: Laboratory of Microscopic and Ultrastructural Anatomy, CIR, University Campus Bio-Medico, Rome, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Carotti
authors.affiliation: Laboratory of Microscopic and Ultrastructural Anatomy, CIR, University Campus Bio-Medico, Rome, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Morini
authors.affiliation: Unit of Neuromuscolar and Neurodegenerative Diseases, Children's Hospital and Research Institute "Bambino Gesù", Rome, Italy.
authors.forename: Jessica
authors.initials: J
authors.lastname: D'Amico
authors.affiliation: Clinical Pathology and Microbiology Laboratory, University Campus Bio-Medico, Rome, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Angeletti
authors.affiliation: Area of Geriatrics, University Campus Bio-Medico, Rome, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Pedone
authors.affiliation: Internal Medicine and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Picardi
mesh_terms: D000368:Aged; D015536:Down-Regulation; D059788:Dried Blood Spot Testing; D005260:Female; D020022:Genetic Predisposition to Disease; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D007958:Leukocyte Count; D008103:Liver Cirrhosis / Q000151:congenital* / Q000201:enzymology* / Q000209:etiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D002787:Sterol Esterase / Q000235:genetics* / Q000378:metabolism*
chemical_list: C503451:LIPA protein, human; D002787:Sterol Esterase