title: Increased concentrations of soluble B7-H3 and interleukin 36 in bronchoalveolar lavage fluid of Children with Mycoplasma pneumoniae pneumonia.
abstract: The purpose of this study is to explore the correlations of interleukin 36 (IL-36) and Soluble B7-H3 (sB7-H3) levels in bronchoalveolar lavage fluid (BALF) with clinical characteristics and laboratory findings.
  
  
  
  A total of 35 children with M. pneumnoiae pneumonia (MPP) and 15 control subjects were enrolled. BALF concentrations of sB7-H3 and IL-36 were detected using enzyme-linked immunosorbent assays and clinical profiles of children with MPP were obtained.
  
  
  
  Children with MPP had significantly higher levels of sB7-H3 and IL-36 compared to control subjects (both P < 0.05). Meanwhile, children with pleural effusion had significantly higher levels of sB7-H3 and IL-36 compared to children without pleural effusion (both P < 0.05). BALF concentration of sB7-H3 was strongly associated with concentration of IL-36 (r = 0.796, P < 0.0001) and sB7-H3 was correlated with duration of fever (r = 0.427, P = 0.11) and length of stay (r = 0.345, P = 0.043). Both concentrations of sB7-H3 and IL-36 were significantly decreased in convalescent phase after treatment (both P < 0.05).
  
  
  
  Both soluble B7-H3 and IL-36 may play an important role in pathogenesis of M. pneumoniae infection and sB7-H3 could be useful as a prognostic predictor or biomarker of MPP.
authors.affiliation: Department of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
authors.forename: Zhengrong
authors.initials: Z
authors.lastname: Chen
authors.affiliation: General surgery department, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
authors.forename: Xinxing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Clinical Immunology Laboratory, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
authors.forename: Guangbo
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
authors.forename: Huiming
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
authors.forename: Wujun
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China.
authors.forename: Canhong
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Department of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China. szdxjiwei@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Ji
authors.affiliation: Department of Respiratory Disease, Children's Hospital of Soochow University, Soochow University, Suzhou, China. yyd3060@163.com.
authors.forename: Yongdong
authors.initials: Y
authors.lastname: Yan
mesh_terms: D000293:Adolescent; D060887:B7 Antigens / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D007375:Interleukin-1 / Q000097:blood*; D008297:Male; D009177:Mycoplasma pneumoniae / Q000235:genetics / Q000302:isolation & purification*; D011019:Pneumonia, Mycoplasma / Q000097:blood* / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000382:microbiology
chemical_list: D060887:B7 Antigens; D015415:Biomarkers; C423237:CD276 protein, human; D007375:Interleukin-1; C572887:interleukin 36, human
keywords: B7-H3; Bronchoalveolar lavage fluid; Children; Interleukin 36; Mycoplasma pneumoniae pneumonia