title: A Surface-Confined Proton-Driven DNA Pump Using a Dynamic 3D DNA Scaffold.
abstract: A proton-driven molecular pump is devised using a surface-confined dynamic 3D DNA scaffold. A dynamic DNA tetrahedral nanostructure is designed by incorporating a pH-sensitive i-motif sequence in one edge, which serves as the scaffold to ensure highly ordered orientation and spatial isolation of this nanomachine on the macroscopic gold surface. It is found that the switching ability of this dynamic tetrahedron is fully maintained on the surface. Importantly, this proton-driven nanomachine can reversibly pump water and ferricynide in response to pH variation in solution.
authors.affiliation: Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.|Key Laboratory for Organic Electronics & Information Displays (KLOEID) and Institute of Advanced Materials (IAM), School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications, Nanjing, 210023, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhu
authors.affiliation: Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.|School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Pei
authors.affiliation: Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
authors.forename: Guangbao
authors.initials: G
authors.lastname: Yao
authors.affiliation: Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key Laboratory for Organic Electronics & Information Displays (KLOEID) and Institute of Advanced Materials (IAM), School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications, Nanjing, 210023, China.
authors.forename: Shao
authors.initials: S
authors.lastname: Su
authors.affiliation: Key Laboratory for Organic Electronics & Information Displays (KLOEID) and Institute of Advanced Materials (IAM), School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications, Nanjing, 210023, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chao
authors.affiliation: Key Laboratory for Organic Electronics & Information Displays (KLOEID) and Institute of Advanced Materials (IAM), School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications, Nanjing, 210023, China.
authors.forename: Lianhui
authors.initials: L
authors.lastname: Wang
authors.affiliation: Chemistry Department, King Saud University, Riyadh, 11451, Saudi Arabia.
authors.forename: Ali
authors.initials: A
authors.lastname: Aldalbahi
authors.affiliation: Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
authors.forename: Shiping
authors.initials: S
authors.lastname: Song
authors.affiliation: UCB Pharma, 208 Bath Road, Slough, SL1 3WE, UK.
authors.forename: Jiye
authors.initials: J
authors.lastname: Shi
authors.affiliation: Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.affiliation: Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
authors.forename: Chunhai
authors.initials: C
authors.lastname: Fan
authors.affiliation: Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zuo
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D005292:Ferricyanides / Q000378:metabolism; D006046:Gold; D006863:Hydrogen-Ion Concentration; D049329:Nanostructures / Q000737:chemistry; D011522:Protons; D012996:Solutions; D014867:Water / Q000378:metabolism
chemical_list: D005292:Ferricyanides; D011522:Protons; D012996:Solutions; D014867:Water; D006046:Gold; D004247:DNA
keywords: DNA nanostructures; dynamic nanodevices; nanopumps; reversible; surface-confined