title: [Clinical and bacteriological profile of neonatal bacterial infection at Laquintinie Hospital, Douala (Cameroon)].
abstract: BACKGROUND
  The World Health Organization has estimated that the global incidence of neonatal deaths was 2,8 million in 2015, of which 47,6% were due to infections. These infections can affect newborns babies ages 0-1 month through 3 months.
  
  
  METHODS
  This is a prospective study conducted from 1 March to 30 June 2015 in the Neonatology service of the Laquintinie Hospital at Douala. All symptomatic newborns with or without anamnestic criteria and all asymptomatic newborns, with at least an infectious risk and a positive blood culture or an abnormal blood count or positive C-reactive protein were included in the study.
  
  
  RESULTS
  Of the 310 newborns enrolled in the study, 300 were retained for neonatal infection, corresponding to a total incidence of 96.8%. We performed 104 cultures, of which 25 were positive, corresponding to an incidence of confirmed neonatal infection of 24%. The factors associated with infection were unexplained preterm birth < 35 weeks of amenorrhea (45,1%) and neonatal resuscitation (34,8%). Fever (56%) and neurological disorders (48.8%) were the most frequent clinical symptoms. Gram-negative bacteria were the most frequent germs (56%). Imipenem (95%) and amikacin (66.7%) were the most effective antibiotics. Outcome was favorable in 66,4% of cases and the overall mortality rate was 33,6%.
  
  
  CONCLUSIONS
  This study revealed a high prevalence of neonatal bacterial infection in this Hospital. Bacterial ecology was dominated by Gram-negative bacteria. It was recorded a significant resistance to the most widely used antibiotics and a fairly high mortality.
authors.affiliation: Institut Supérieure des Sciences de la Santé, Université des Montagnes, Bangangté, Cameroun.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Kemeze
authors.affiliation: Département de Pédiatrie, Hôpital Laquintinie de Douala, Cameroun.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Moudze
authors.affiliation: Service de Pédiatrie et sous Spécialités Pédiatriques, Hôpital Gynéco-Obstétrique et Pédiatrique de Yaoundé, Cameroun; Faculté de Médecine et des Sciences Biomédicales de Yaoundé, Cameroun.
authors.forename: Andreas
authors.initials: A
authors.lastname: Chiabi
authors.affiliation: Département de Pédiatrie, Hôpital Laquintinie de Douala, Cameroun.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Eposse
authors.affiliation: Département de Pédiatrie, Hôpital Laquintinie de Douala, Cameroun.
authors.forename: Alexis
authors.initials: A
authors.lastname: Kaya
authors.affiliation: Laboratoire d'Analyse Biomédical, Hôpital Laquintinie de Douala, Cameroun.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Mbangue
authors.affiliation: Institut Supérieure des Sciences de la Santé, Université des Montagnes, Bangangté, Cameroun.
authors.forename: Odette
authors.initials: O
authors.lastname: Guifo
authors.affiliation: Faculté de Médecine et des Sciences Biomédicales de Yaoundé, Cameroun.
authors.forename: Innocent
authors.initials: I
authors.lastname: Kago
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D002097:C-Reactive Protein / Q000378:metabolism; D002163:Cameroon / Q000453:epidemiology; D005260:Female; D005334:Fever / Q000453:epidemiology / Q000382:microbiology; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D008297:Male; D015995:Prevalence; D011446:Prospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D002097:C-Reactive Protein
keywords: Cameroon; Neonatal bacterial infection; bacterial ecology; clinical