title: Synthesis of Novel Symmetrical 1,4-Disubstituted 1,2,3-Bistriazole Derivatives via 'Click Chemistry' and Their Biological Evaluation.
abstract: A series of symmetric bis-1,2,3-triazole compounds 2-5(a-f) were synthesized as potential antioxidant agents via click chemistry. Their structures were confirmed by ¹H-NMR and (13)C-NMR. All of the synthesized compounds were subjected to antioxidant and antimicrobial assays. The antioxidant activity of these compounds (AChE inhibition, DPPH and SOD activities) was evaluated. Compound 2f was found to show the highest AChE inhibition activity of all compounds, while compound 3b showed a strong inhibitory effect on DPPH radical and compound 2a was the most effective of all compounds for SOD activity. All synthesized compounds were found to possess moderate antibacterial activity against the bacteria E. coli and Y.pseudotuberculosis.
authors.affiliation: Department of Chemistry, Karadeniz Technical University, Trabzon 61080, Turkey. esradugdu@gmail.com.
authors.forename: Esra
authors.initials: E
authors.lastname: Düğdü
authors.affiliation: Department of Chemistry, Karadeniz Technical University, Trabzon 61080, Turkey. dunluer@yahoo.com.
authors.forename: Dilek
authors.initials: D
authors.lastname: Ünlüer
authors.affiliation: Department of Chemistry, Karadeniz Technical University, Trabzon 61080, Turkey. fatih.celik@ktu.edu.tr.
authors.forename: Fatih
authors.initials: F
authors.lastname: Çelik
authors.affiliation: Department of Chemistry, Karadeniz Technical University, Trabzon 61080, Turkey. ksancak@ktu.edu.tr.
authors.forename: Kemal
authors.initials: K
authors.lastname: Sancak
authors.affiliation: Department of Biology, Recep Tayyip Erdoğan University, Rize 53100, Turkey. sengul.karaoglu@erdogan.edu.tr.
authors.forename: Şengül
authors.initials: Ş
authors.lastname: Alpay Karaoğlu
authors.affiliation: Faculty of Pharmacy, Karadeniz Technical University, Trabzon 61080, Turkey. arzuozenozel@ktu.edu.tr.
authors.forename: Arzu
authors.initials: A
authors.lastname: Özel
mesh_terms: D066241:Carbon-13 Magnetic Resonance Spectroscopy; D057930:Click Chemistry; D066244:Proton Magnetic Resonance Spectroscopy; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D014230:Triazoles
keywords: 1,2,3-triazole; 1,3-dipolar cycloaddition; antimicrobial activity; antioxidant activity