title: Graves' hyperthyroidism accompanied with acute hepatitis B virus infection: an extrahepatic manifestation?
abstract: BACKGROUND
  Although hepatitis B virus (HBV) primarily affects hepatocytes, it has also been shown to cause complications in the skin, joints, muscles, and kidneys. Thyroid dysfunction is uncommon in cases of acute HBV infection.
  
  
  METHODS
  In this report, we describe a case of a 46-year-old woman with incipient acute hepatitis B virus (HBV) infection who presented clinically with Graves' hyperthyroidism. She showed typical symptoms of hyperthyroidism, and laboratory tests revealed high levels of HBV DNA and alanine transaminase (ALT). The patient was not administered with antithyroid medicine or radioiodine, but she was given antiviral therapy and symptomatic treatment with propranolol. Follow-up studies showed that as the HBV DNA levels decreased, the thyroid function recovered.
  
  
  CONCLUSIONS
  Graves' disease maybe an extrahepatic manifestation of acute HBV infection. Antiviral therapy is likely to be beneficial for this condition as without severe thyrotoxicosis.
authors.affiliation: Department of Infectious Diseases, the First Affiliated Hospital, China Medical University, Shenyang, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.affiliation: Department of Infectious Diseases, the First Affiliated Hospital, China Medical University, Shenyang, China.
authors.forename: Baocheng
authors.initials: B
authors.lastname: Deng
authors.affiliation: Department of Infectious Diseases, the First Affiliated Hospital, China Medical University, Shenyang, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Infectious Diseases, the First Affiliated Hospital, China Medical University, Shenyang, China. weicuisy@163.com.
authors.forename: Pei
authors.initials: P
authors.lastname: Liu
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D006111:Graves Disease / Q000175:diagnosis* / Q000473:pathology*; D006509:Hepatitis B / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents
keywords: Antiviral; Extrahepatic manifestation; Graves’ hyperthyroidism; HBV infection