title: Prospective assessment of serum periostin as a biomarker for diagnosis and monitoring of eosinophilic oesophagitis.
abstract: Periostin is highly expressed in eosinophilic oesophagitis (EoE), but has not been extensively studied as a non-invasive biomarker.
  
  
  
  To assess whether serum periostin distinguished EoE from controls at baseline, had utility for monitoring treatment response, or was associated with IL-13 levels.
  
  
  
  This was a sub-analysis of a prospective cohort study of adults undergoing out-patient upper endoscopy. Incident cases of EoE were diagnosed per consensus guidelines. Controls were subjects with either GERD or dysphagia without EoE. EoE patients were treated with swallowed/topical steroids and had repeat endoscopy/biopsy. Serum periostin levels for cases and controls were compared at baseline, and pre/post-treatment levels were compared for cases. Serum IL-13 and tissue expression of periostin were also assessed.
  
  
  
  A total of 61 incident EoE cases and 87 controls were analysed. Despite a marked increase in tissue periostin expression in cases, the median baseline serum periostin level was only slightly higher in cases than controls (22.1 ng/mL vs. 20.7; P = 0.04); there was no change in post-treatment levels. There was also no difference in serum periostin for cases by histologic response or atopic status. There was a strong trend towards higher serum IL-13 levels in cases in the highest periostin quartile (57.1 pg/mL vs. 2.6; P = 0.07).
  
  
  
  Serum periostin levels were similar in cases and controls, and there were no changes post-treatment. Given elevated IL-13 levels in the EoE patients with the highest periostin levels, future studies could explore periostin as a biomarker in EoE, perhaps in the setting of anti-IL-13 therapy.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.|Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Dellon
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: L L
authors.initials: LL
authors.lastname: Higgins
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: R
authors.initials: R
authors.lastname: Beitia
authors.affiliation: Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: S
authors.initials: S
authors.lastname: Rusin
authors.affiliation: Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Woosley
authors.affiliation: Miraca Life Sciences Research Institute, Irving, TX, USA.
authors.forename: R
authors.initials: R
authors.lastname: Veerappan
authors.affiliation: Department of Genetics, University of Chapel Hill, Chapel Hill, NC, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Selitsky
authors.affiliation: Department of Genetics, University of Chapel Hill, Chapel Hill, NC, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Parker
authors.affiliation: Miraca Life Sciences Research Institute, Irving, TX, USA.|Dallas Veterans Affairs Medical Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Genta
authors.affiliation: Miraca Life Sciences Research Institute, Irving, TX, USA.
authors.forename: R H
authors.initials: RH
authors.lastname: Lash
authors.affiliation: Receptos, San Diego, CA, USA.
authors.forename: R
authors.initials: R
authors.lastname: Aranda
authors.affiliation: Receptos, San Diego, CA, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Peach
authors.affiliation: Receptos, San Diego, CA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Grimm
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D015815:Cell Adhesion Molecules / Q000097:blood*; D003680:Deglutition Disorders / Q000175:diagnosis; D004724:Endoscopy / Q000379:methods; D057765:Eosinophilic Esophagitis / Q000175:diagnosis*; D005260:Female; D006801:Humans; D018793:Interleukin-13 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D018793:Interleukin-13; C512835:POSTN protein, human