title: [Role of serum leptin in the severity of coronary artery disease in patients with stable angina].
abstract: OBJECTIVE
  Leptin is a plasmatic peptide hormone that has been related to cardiovascular homeostasis and atherosclerosis but much is still unknown about its relationship with coronary artery disease. The aim of this study was to evaluate the value of serum leptin in patients with stable angina and its relationship with the severity of coronary disease.
  
  
  METHODS
  204 patients, 152 with stable angina (coronary artery disease group) and 52 without coronary disease excluded by cardiac computerized tomography (control group) were included. The coronary artery disease group was divided into 2 subgroups according to severity of coronary disease (single or multivessel disease, 46 and 106 patients, respectively). Serum leptin levels were determined by Enzyme-Linked InmunoSorbent Assay.
  
  
  RESULTS
  Leptin levels were significantly higher in patients with multivessel disease and were independently associated with a greater severity of coronary artery disease when compared with controls (OR 1.14; 95%CI: 1.03-1.27; p=0.014) and with patients with single vessel disease (OR 1.12; 95%CI: 1.01-1.25; p=0.036). Serum leptin was tested as a diagnostic marker of multivessel disease with an area under the curve obtained from Receiver Operating Characteristics of 0.6764 (95%CI 0.5765-0.7657).
  
  
  CONCLUSIONS
  Serum leptin levels were associated in patients with stable angina with the severity of coronary artery disease, suggesting its value in the development of coronary disease and as a future therapeutic target.
authors.affiliation: Unidad de Gestión Clínica del Corazón, Hospital Clínico Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), Red de Investigación Cardiovascular (RIC), Málaga, España.
authors.forename: Miguel
authors.initials: M
authors.lastname: Jerez-Valero
authors.affiliation: Unidad de Gestión Clínica del Corazón, Hospital Clínico Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), Red de Investigación Cardiovascular (RIC), Málaga, España.
authors.forename: Ana
authors.initials: A
authors.lastname: Meliveo-García
authors.affiliation: Unidad de Gestión Clínica del Corazón, Hospital Clínico Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), Red de Investigación Cardiovascular (RIC), Málaga, España.
authors.forename: Laura
authors.initials: L
authors.lastname: Jordán-Martínez
authors.affiliation: Unidad de Gestión Clínica del Corazón, Hospital Clínico Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), Red de Investigación Cardiovascular (RIC), Málaga, España.
authors.forename: Fernando
authors.initials: F
authors.lastname: Carrasco-Chinchilla
authors.affiliation: Unidad de Gestión Clínica del Corazón, Hospital Clínico Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), Red de Investigación Cardiovascular (RIC), Málaga, España.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Moreno-Santos
authors.affiliation: Unidad de Gestión Clínica del Corazón, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Universidad de Sevilla (US), Red de Investigación Cardiovascular (RIC), Sevilla, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ordóñez
authors.affiliation: Servicio de Cardiología, Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBISAL), Universidad de Salamanca (USAL), Red de Investigación Cardiovascular (RIC), Salamanca, España.
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Sánchez-Fernández
authors.affiliation: Unidad de Gestión Clínica del Corazón, Hospital Universitario Puerta del Mar, Cádiz, Universidad de Cádiz (UCA), Red de Investigación Cardiovascular (RIC), Cádiz, España.
authors.forename: Rafael
authors.initials: R
authors.lastname: Vázquez
authors.affiliation: Unidad de Gestión Clínica del Corazón, Hospital Clínico Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), Red de Investigación Cardiovascular (RIC), Málaga, España.
authors.forename: José M
authors.initials: JM
authors.lastname: Hernández-García
authors.affiliation: Unidad de Gestión Clínica del Corazón, Hospital Clínico Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), Red de Investigación Cardiovascular (RIC), Málaga, España.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Gómez-Doblas
authors.affiliation: Unidad de Gestión Clínica del Corazón, Hospital Clínico Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), Red de Investigación Cardiovascular (RIC), Málaga, España. Electronic address: luismiguelpb1984@gmail.com.
authors.forename: Luis M
authors.initials: LM
authors.lastname: Pérez-Belmonte
authors.affiliation: Unidad de Gestión Clínica del Corazón, Hospital Clínico Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), Red de Investigación Cardiovascular (RIC), Málaga, España.
authors.forename: Eduardo
authors.initials: E
authors.lastname: de Teresa-Galván
authors.affiliation: Unidad de Gestión Clínica del Corazón, Hospital Clínico Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), Red de Investigación Cardiovascular (RIC), Málaga, España.
authors.forename: Manuel
authors.initials: M
authors.lastname: Jiménez-Navarro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060050:Angina, Stable / Q000097:blood / Q000150:complications*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D020738:Leptin
keywords: Angina estable; Coronary artery disease; Enfermedad arterial coronaria; Leptin; Leptina; Stable angina