title: Random-start controlled ovarian stimulation for emergency fertility preservation in a patient with myelodysplastic syndrome: a case report.
abstract: This study reports a case of a gonadotropin-releasing hormone agonist trigger in a young female with myelodysplastic syndrome (MDS) who underwent fertility preservation using random-start controlled ovarian stimulation. This method involves the stimulation of the ovary regardless of a patient's menstrual-cycle phase. A review of the related literature is also provided. A 17-year-old patient was diagnosed with MDS and required initiation of peripheral blood stem cell transplantation within a maximum of 3 weeks and was in the luteal phase of the menstrual cycle when the possibility of attempting preservation of fertility was presented to her. She opted for a random-start controlled ovarian stimulation with gonadotropins. With successful hemorrhagic prophylaxis, 17 oocytes were retrieved including 10 mature and 7 immature oocytes. Of the immature oocytes, 3 were successfully matured in vitro and a vitrification protocol was used to freeze the 13 mature oocytes.
authors.affiliation: Reproductive Medical Center, Peking University People's Hospital, Beijing, China.
authors.forename: H
authors.initials: H
authors.lastname: Cai
authors.affiliation: Reproductive Medical Center, Peking University People's Hospital, Beijing, China.
authors.forename: H
authors.initials: H
authors.lastname: Shen
mesh_terms: D000293:Adolescent; D015925:Cryopreservation / Q000379:methods; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology; D009190:Myelodysplastic Syndromes / Q000503:physiopathology*; D054315:Oocyte Retrieval / Q000379:methods; D009865:Oocytes / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods*; D015203:Reproducibility of Results; D016896:Treatment Outcome