title: Multidimensional aspects of pain in myotonic dystrophies.
abstract: To analyze the frequency and intensity of pain and its association with different characteristics of patients with myotonic dystrophy type 1 (DM1) and type 2 (DM2), 52 adult genetically confirmed DM1 and 44 DM2 patients completed the Brief Pain Inventory questionnaire (BPI). Frequency and average intensity of pain on numerical rating scale (0-10) were similar in DM1 and DM2 (88% vs. 86% and 4.6 ± 2.3 vs. 4.2 ± 1.8, respectively, p > 0.05). In DM1, average pain intensity showed strong association with longer duration of disease and inverse relation with cognition. In DM2, average pain intensity showed association with female gender and emotions. Average pain intensity correlated with Individualized Neuromuscular Quality of Life (INQoL) total score in both DM1 (rho = +0.30, p < 0.05) and DM2 patients (rho = +0.61, p < 0.01). In conclusion, the majority of DM1 and DM2 patients have mild to moderate pain. Our results open new opportunities for behavioral and cognitive interventions.
authors.affiliation: Mother and Child Health Care Institute, Belgrade, Serbia;
authors.forename: Marina
authors.initials: M
authors.lastname: Peric
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Stojan
authors.initials: S
authors.lastname: Peric
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Nada
authors.initials: N
authors.lastname: Rapajic
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Valerija
authors.initials: V
authors.lastname: Dobricic
authors.affiliation: Center for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Serbia.
authors.forename: Dusanka
authors.initials: D
authors.lastname: Savic-Pavicevic
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Ivana
authors.initials: I
authors.lastname: Nesic
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Svetlana
authors.initials: S
authors.lastname: Radojicic
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Ivana
authors.initials: I
authors.lastname: Novakovic
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Dragana
authors.initials: D
authors.lastname: Lavrnic
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Vidosava
authors.initials: V
authors.lastname: Rakocevic-Stojanovic
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000503:physiopathology*; D010147:Pain Measurement / Q000379:methods*; D011788:Quality of Life; D011795:Surveys and Questionnaires
keywords: myotonic dystrophy type 1; myotonic dystrophy type 2; pain; quality of life