title: Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration.
abstract: Neuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. N-acylethanolamides (NAEs), naturally occurring amides, are known for their pro-homeostatic effects. An increase in NAEs has been reported in vivo and in vitro in the aging brain and in brain injury. Treatment with NAEs may promote neuroprotection and exert anti-inflammatory actions via PPARα activation and/or by counteracting gliosis. This review aims to provide an overview of endogenous and exogenous properties of NAEs in neuroinflammation and to discuss their interaction with glial cells.
authors.affiliation: Instituto de Investigaciones Cardiológicas, Facultad de Medicina, Universidad de Buenos Aires - Consejo Nacional de Investigaciones Científicas y TécnicasBuenos Aires, Argentina; Centro de Investigaciones en Psicología y Psicopedagogía, Facultad de Psicología, Universidad Católica ArgentinaBuenos Aires, Argentina.
authors.forename: María I
authors.initials: MI
authors.lastname: Herrera
authors.affiliation: Instituto de Investigaciones Cardiológicas, Facultad de Medicina, Universidad de Buenos Aires - Consejo Nacional de Investigaciones Científicas y Técnicas Buenos Aires, Argentina.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Kölliker-Frers
authors.affiliation: Department of Nutrition and Biochemistry, Faculty of Sciences, Pontificia Universidad Javeriana Bogotá, Colombia.
authors.forename: George
authors.initials: G
authors.lastname: Barreto
authors.affiliation: Departament de Pedagogia i Psicologia, Facultat d'Educació, Psicologia i Treball Social, Universitat de Lleida Lleida, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Blanco
authors.affiliation: Instituto de Investigaciones Cardiológicas, Facultad de Medicina, Universidad de Buenos Aires - Consejo Nacional de Investigaciones Científicas y TécnicasBuenos Aires, Argentina; Facultad de Psicología, Universidad Católica ArgentinaBuenos Aires, Argentina; Departamento de Biología, Universidad Argentina John F. KennedyBuenos Aires, Argentina; Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de ChileSantiago, Chile.
authors.forename: Francisco
authors.initials: F
authors.lastname: Capani
keywords: N-acylethanolamides; PPARα; gliosis; neuroinflammation; neuroprotection