title: Drugs affecting glycosaminoglycan metabolism.
abstract: Glycosaminoglycans (GAGs) are charged polysaccharides ubiquitously present at the cell surface and in the extracellular matrix. GAGs are crucial for cellular homeostasis, and their metabolism is altered during pathological processes. However, little consideration has been given to the regulation of the GAG milieu through pharmacological interventions. In this review, we provide a classification of small molecules affecting GAG metabolism based on their mechanism of action. Furthermore, we present evidence to show that clinically approved drugs affect GAG metabolism and that this could contribute to their therapeutic benefit.
authors.affiliation: Glyconova Srl, Parco Scientifico Silvano Fumero, Via Ribes 5, 10010 Colleretto Giacosa (TO), Italy. Electronic address: giancarlo.ghiselli@gmail.com.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Ghiselli
authors.affiliation: Department of Experimental Medical Science, Biomedical Center C12, Lund University, Tornavägen 10, SE-221 84 Lund, Sweden.
authors.forename: Marco
authors.initials: M
authors.lastname: Maccarana
mesh_terms: D000818:Animals; D006025:Glycosaminoglycans / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D004364:Pharmaceutical Preparations; D000069437:Pharmacological Phenomena
chemical_list: D006025:Glycosaminoglycans; D004364:Pharmaceutical Preparations