title: An observational study of sequential protein-sparing, very low-calorie ketogenic diet (Oloproteic diet) and hypocaloric Mediterranean-like diet for the treatment of obesity.
abstract: The impact of a rehabilitative multi-step dietary program consisting in different diets has been scantily investigated. In an open-label study, 73 obese patients underwent a two-phase weight loss (WL) program: a 3-week protein-sparing, very low-calorie, ketogenic diet (<500 kcal/day; Oloproteic(®) Diet) and a 6-week hypocaloric (25-30 kcal/kg of ideal body weight/day), low glycemic index, Mediterranean-like diet (hypo-MD). Both phases improved visceral adiposity, liver enzymes, GH levels, blood pressure and glucose and lipid metabolism. However, the hypo-MD was responsible for a re-increase in blood lipids and glucose tolerance parameters. Changes in visceral adiposity and glucose control-related variables were more consistent in patients with metabolic syndrome. However, in these patients the hypo-MD did not result in a consistent re-increase in glucose control-related variables. A dietary program consisting in a ketogenic regimen followed by a balanced MD appeared to be feasible and efficacious in reducing cardiovascular risk, particularly in patients with metabolic syndrome.
authors.affiliation: a Clinical Nutrition Unit, A.O.R.N. "San Giuseppe Moscati" , Contrada Amoretta , Avellino , Italy ;
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Castaldo
authors.affiliation: b Ultrasonography Unit, A.O.R.N. "San Giuseppe Moscati" , Contrada Amoretta , Avellino , Italy ;
authors.forename: Luigi
authors.initials: L
authors.lastname: Monaco
authors.affiliation: a Clinical Nutrition Unit, A.O.R.N. "San Giuseppe Moscati" , Contrada Amoretta , Avellino , Italy ;
authors.forename: Laura
authors.initials: L
authors.lastname: Castaldo
authors.affiliation: a Clinical Nutrition Unit, A.O.R.N. "San Giuseppe Moscati" , Contrada Amoretta , Avellino , Italy ;
authors.forename: Giovanna
authors.initials: G
authors.lastname: Galdo
authors.affiliation: c Nutrition and Dietetics Service , Fondazione IRCCS Policlinico San Matteo , Viale Golgi , Pavia , Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Cereda
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D031204:Caloric Restriction; D002318:Cardiovascular Diseases / Q000097:blood / Q000517:prevention & control; D003404:Creatinine / Q000097:blood; D055423:Diet, Ketogenic; D038441:Diet, Mediterranean; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D038321:Glycemic Index; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000178:diet therapy; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy*; D011446:Prospective Studies; D014527:Uric Acid / Q000097:blood
chemical_list: D001786:Blood Glucose; D003404:Creatinine; D006442:Glycated Hemoglobin; D008055:Lipids; D014527:Uric Acid
keywords: Ketogenic diet; Mediterranean diet; obesity; weight loss