title: Antipsychotic-Induced Neuroleptic Malignant Syndrome After Cardiac Surgery.
abstract: We report a case of neuroleptic malignant syndrome (NMS) in a postoperative cardiac surgery patient after the administration of typical and atypical antipsychotics for the treatment of delirium. On postoperative day 8, the patient's temperature peaked at 40.6°C. Agitation, rigidity, elevation in creatine kinase, and leukocytosis were associated findings. NMS was suspected on postoperative day 10. All antipsychotics were discontinued; dantrolene infusions and fluid therapy were initiated. After 2 days of NMS treatment, the patient's symptoms resolved. The temporal relationship between discontinuation of all antipsychotics, initiation of dantrolene, and clinical improvement supports the diagnosis of antipsychotic-induced NMS.
authors.affiliation: From the *Department of Anesthesiology, Emory Center of Critical Care, Emory School of Medicine, Atlanta, Georgia; and †Pharmaceutical Services, Emory University Hospital Midtown, Atlanta, Georgia.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Moll
authors.forename: Ceressa T
authors.initials: CT
authors.lastname: Ward
authors.forename: Joel B
authors.initials: JB
authors.lastname: Zivot
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis* / Q000209:etiology*
chemical_list: D014150:Antipsychotic Agents