title: [Surgical Resection and Adjuvant Chemotherapy with FOLFOX6 for Primary Duodenal Adenocarcinoma and Nodal Metastasis Resulted in Complete Remission].
abstract: Primary duodenal adenocarcinoma is a rare disease, and cases with nodal metastases have a poor prognosis. A 46-year-old man complaining of bloody stool visited our hospital. Endoscopy, CT, and PET-CT showed adenocarcinoma in the 2nd portion of the duodenum. We performed radical resection (PpPD) and pathological findings showed T3N1M0 (Stage III). Chemotherapy consisting of FOLFOX6 was administered for 6 months after surgery. The patient was alive without recurrence 5 years later. This case suggests that adjuvant chemotherapy (FOLFOX regimen) following curative resection including lymph node removal is an effective treatment for cases with tumor involvement of the lymph nodes.
authors.affiliation: Section of Chemotherapy, JA Hiroshima General Hospital.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Imamura
authors.forename: Masaru
authors.initials: M
authors.lastname: Sasaki
authors.forename: Mohei
authors.initials: M
authors.lastname: Kouyama
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Tazaki
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Yuta
authors.initials: Y
authors.lastname: Kuroo
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakamitsu
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Daimaru
authors.forename: Yumi
authors.initials: Y
authors.lastname: Yabuta
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shirai
authors.forename: Kengo
authors.initials: K
authors.lastname: Uzuhashi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D004379:Duodenal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D011379:Prognosis; D012074:Remission Induction
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil