title: Novel bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution for Renilla luciferase.
abstract: Two series of novel coelenterazine analogues (alkynes and triazoles) with imidazopyrazinone C-6 extended substitution have been designed and synthesized successfully for the extension of bioluminescent substrates. After extensive evaluation, some compounds display excellent bioluminescence properties compared with DeepBlueC in cellulo, thus becoming potential molecules for bioluminescence techniques.
authors.affiliation: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China. mli@sdu.edu.cn.
authors.forename: Tianyu
authors.initials: T
authors.lastname: Jiang
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Yang
authors.forename: Xingye
authors.initials: X
authors.lastname: Yang
authors.forename: Mingliang
authors.initials: M
authors.lastname: Yuan
authors.forename: Tianchao
authors.initials: T
authors.lastname: Zhang
authors.forename: Huateng
authors.initials: H
authors.lastname: Zhang
authors.forename: Minyong
authors.initials: M
authors.lastname: Li
mesh_terms: D045744:Cell Line, Tumor; D057930:Click Chemistry; D006801:Humans; D007093:Imidazoles / Q000737:chemistry*; D049410:Luciferases, Renilla / Q000737:chemistry*; D008163:Luminescent Measurements; D011719:Pyrazines / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*
chemical_list: D007093:Imidazoles; D011719:Pyrazines; D011720:Pyrazoles; C026262:imidazopyrazole; C017144:coelenterazine; D049410:Luciferases, Renilla