title: Intranasal corticosteroid therapy in the treatment of obstructive sleep apnea: A meta-analysis of randomized controlled trials.
abstract: OBJECTIVE
  To assess the efficacy of intranasal corticosteroid therapy in the treatment of obstructive sleep apnea (OSA) based on current evidence.
  
  
  METHODS
  A number of medical literature data bases: PubMed, Cochrane Library, Scopus, and CINAHL, were searched comprehensively to identify randomized controlled trials (RCT) that reported on the efficacy of intranasal corticosteroid therapy for OSA. The selected studies were subjected to a meta-analysis and a risk-of-bias assessment.
  
  
  RESULTS
  Seven RCTs met our eligibility criteria, five of these were included in our meta-analysis. The results indicated that intranasal corticosteroid therapy has a better effect in decreasing the apnea-hypopnea index compared with those participants who received placebo (standard mean difference 0.95 [95% confidence interval, -1.42 to -0.47]) (n = 221, I(2) = 62%).
  
  
  CONCLUSIONS
  Our study results showed that patients who received intranasal corticosteroid therapy had a significant improvement in OSA. However, this evidence was limited by the potential risk of bias and heterogeneity of the selected RCTs.
authors.affiliation: Department of Family Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Hsien-Ta
authors.initials: HT
authors.lastname: Liu
authors.forename: Ying-Chin
authors.initials: YC
authors.lastname: Lin
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Kuan
authors.forename: Yao-Hsien
authors.initials: YH
authors.lastname: Huang
authors.forename: Wen-Hsuan
authors.initials: WH
authors.lastname: Hou
authors.forename: Tsan-Hon
authors.initials: TH
authors.lastname: Liou
authors.forename: Hung-Chou
authors.initials: HC
authors.lastname: Chen
mesh_terms: D000281:Administration, Intranasal; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D008297:Male; D016032:Randomized Controlled Trials as Topic; D020181:Sleep Apnea, Obstructive / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones