title: Major benzophenone concentrations and influence of food consumption among the general population in Korea, and the association with oxidative stress biomarker.
abstract: Benzophenones (BPs) have been used as sunscreen agents and as ultraviolet stabilizers in plastic surface coatings for food packaging. However, few studies have been performed to examine the level of human exposure to BPs and the potential sources of such exposure. We evaluated the exposure levels to six major BPs (BP-1, BP-2, BP-3, BP-4, BP-8, and 4-hydroxybenzophenone (4-OH-BP)) among the adult population in two cities in Korea, and investigated the potential dietary sources of the BPs. Urinary levels of malondialdehyde (MDA) as an oxidative stress biomarker as well as their association with the levels of BPs were also analyzed. Among the six BPs analyzed, 4-OH-BP, BP-1, BP-3, and BP-4 were detected in 77%, 49%, 27%, and 21% of the population, respectively. BP concentrations were relatively higher in younger (people in their 20s and 30s) cosmetic users and leaner women. Even after the adjustment of age, body mass index, and cosmetic use, the consumption of frozen storage food, instant noodles, and instant coffee was significantly correlated with urinary BPs, and these associations were sex-dependent. No significant correlation was observed between the levels of BPs and levels of MDA. The results of the present study will be useful for developing plans of public health management of BPs.
authors.affiliation: Department of Environmental Health, Graduate School of Yongin University, Yongin, 17092, Republic of Korea.
authors.forename: Bokyung
authors.initials: B
authors.lastname: Kim
authors.affiliation: Department of Environmental Health, Graduate School of Yongin University, Yongin, 17092, Republic of Korea; CRI Global Institute of Toxicology, Croen Research Inc., Suwon, 16614, Republic of Korea.
authors.forename: Bareum
authors.initials: B
authors.lastname: Kwon
authors.affiliation: Department of Environmental Health, Graduate School of Yongin University, Yongin, 17092, Republic of Korea; CRI Global Institute of Toxicology, Croen Research Inc., Suwon, 16614, Republic of Korea.
authors.forename: Sol
authors.initials: S
authors.lastname: Jang
authors.affiliation: Department of Environmental Health, Graduate School of Yongin University, Yongin, 17092, Republic of Korea.
authors.forename: Pan-Gyi
authors.initials: PG
authors.lastname: Kim
authors.affiliation: Department of Environmental Health, Graduate School of Yongin University, Yongin, 17092, Republic of Korea. Electronic address: kyungheeji@yongin.ac.kr.
authors.forename: Kyunghee
authors.initials: K
authors.lastname: Ji
mesh_terms: D000328:Adult; D001577:Benzophenones / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D004032:Diet; D004781:Environmental Exposure / Q000032:analysis; D005260:Female; D005502:Food; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D056910:Republic of Korea
chemical_list: D001577:Benzophenones; D015415:Biomarkers; C047723:benzophenone
keywords: Benzophenone; Food consumption; Malondialdehyde; Storage food