title: Human Adenovirus Associated with Severe Respiratory Infection, Oregon, USA, 2013-2014.
abstract: Several human adenoviruses (HAdVs) can cause respiratory infections, some severe. HAdV-B7, which can cause severe respiratory disease, has not been recently reported in the United States but is reemerging in Asia. During October 2013-July 2014, Oregon health authorities identified 198 persons with respiratory symptoms and an HAdV-positive respiratory tract specimen. Among 136 (69%) hospitalized persons, 31% were admitted to the intensive care unit and 18% required mechanical ventilation; 5 patients died. Molecular typing of 109 specimens showed that most (59%) were HAdV-B7, followed by HAdVs-C1, -C2, -C5 (26%); HAdVs-B3, -B21 (15%); and HAdV-E4 (1%). Molecular analysis of 7 HAdV-B7 isolates identified the virus as genome type d, a strain previously identified only among strains circulating in Asia. Patients with HAdV-B7 were significantly more likely than those without HAdV-B7 to be adults and to have longer hospital stays. HAdV-B7 might be reemerging in the United States, and clinicians should consider HAdV in persons with severe respiratory infection.
authors.forename: Magdalena Kendall
authors.initials: MK
authors.lastname: Scott
authors.forename: Christina
authors.initials: C
authors.lastname: Chommanard
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Lu
authors.forename: Dianna
authors.initials: D
authors.lastname: Appelgate
authors.forename: LaDonna
authors.initials: L
authors.lastname: Grenz
authors.forename: Eileen
authors.initials: E
authors.lastname: Schneider
authors.forename: Susan I
authors.initials: SI
authors.lastname: Gerber
authors.forename: Dean D
authors.initials: DD
authors.lastname: Erdman
authors.forename: Ann
authors.initials: A
authors.lastname: Thomas
mesh_terms: D000258:Adenovirus Infections, Human / Q000175:diagnosis / Q000453:epidemiology* / Q000266:history / Q000821:virology*; D000260:Adenoviruses, Human / Q000145:classification / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D049674:History, 21st Century; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009922:Oregon / Q000453:epidemiology; D010802:Phylogeny; D011159:Population Surveillance; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000266:history / Q000821:virology*; D012720:Severity of Illness Index; D063189:Symptom Assessment; D055815:Young Adult
keywords: Human adenovirus; Human adenovirus 7; Oregon; outbreak; pneumonia; respiratory infection; viruses