title: Ganciclovir ophthalmic gel treatment shortens the recovery time and prevents complications in the adenoviral eye infection.
abstract: The purpose of this study was to determine the effectiveness of ganciclovir ophthalmic gel (GOG) in the treatment of adenoviral eye infection (AEI) by looking at the effect of the drug on shortening recovery time, preventing transmission, reducing sequelae, and on complications such as corneal infiltrates and conjunctival pseudomembranes. 200 patients' examination records were evaluated retrospectively. Patients who were within the first 3 days of AEI were divided into two groups: Group 1 with 100 patients who used artificial tears as treatment, and Group 2 with 100 patients who used GOG plus artificial tears (GAT). All patients underwent an eye examination by the same ophthalmologist on the 1st, 5th, 10th, and 15th day after treatment. Using the examination records, variables were compared using SPSS 22.0. There was a statistically significant difference between Groups 1 and 2. Group 2 showed better and faster response to treatment. There was less transmission to the contralateral eye and environment, and less formation of corneal subepithelial infiltrate and conjunctival pseudomembrane in Group 2. Only three patients in Group 2 had corneal involvement. A comparison of each group pre-treatment and during treatment revealed improved signs and symptoms in Group 2 (p < 0.005). The study showed a trend toward more rapid improvement, less corneal and conjunctival involvement, and less transmission to the contralateral eye and environment in the GAT group. These results need to be confirmed by additional studies.
authors.affiliation: Section of Surgical Sciences, Department of Ophthalmology, Faculty of Medicine, Giresun University, Debboy, 28100, Giresun, Turkey. serkan_zen@hotmail.com.
authors.forename: Serkan
authors.initials: S
authors.lastname: Ozen
authors.affiliation: Section of Surgical Sciences, Department of Ophthalmology, Faculty of Medicine, Giresun University, Debboy, 28100, Giresun, Turkey.
authors.forename: Murat A
authors.initials: MA
authors.lastname: Ozer
mesh_terms: D000257:Adenoviridae Infections / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage*; D003228:Conjunctiva / Q000473:pathology; D003315:Cornea / Q000473:pathology; D015828:Eye Infections, Viral / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D015774:Ganciclovir / Q000008:administration & dosage*; D005782:Gels / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D000998:Antiviral Agents; D005782:Gels; D009883:Ophthalmic Solutions; D015774:Ganciclovir
keywords: Adenoviral eye infection; Artificial tear; Ganciclovir