title: Implementation of Molecular Surveillance After a Cluster of Fatal Toxoplasmosis at 2 Neighboring Transplant Centers.
abstract: After a cluster of fatal toxoplasmosis among stem cell transplant recipients at 2 hospitals, surveillance with polymerase chain reaction (PCR) (blood) was instituted. Rate of reactivation among seropositive recipients was 2.2 and 16%. Parasitemia was successfully managed with preemptive treatment. For seropositive recipients unable to take prophylaxis, toxoplasma PCR surveillance should be routinely performed.
authors.affiliation: Infectious Diseases Department of Medicine.
authors.forename: Flonza
authors.initials: F
authors.lastname: Isa
authors.affiliation: Infectious Diseases Department of Medicine.
authors.forename: Kohta
authors.initials: K
authors.lastname: Saito
authors.affiliation: Department of Infectious Disease Service.
authors.forename: Yao-Ting
authors.initials: YT
authors.lastname: Huang
authors.affiliation: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College.
authors.forename: Audrey
authors.initials: A
authors.lastname: Schuetz
authors.affiliation: Department of Clinical Laboratories, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: N Esther
authors.initials: NE
authors.lastname: Babady
authors.affiliation: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College.
authors.forename: Steven
authors.initials: S
authors.lastname: Salvatore
authors.affiliation: Department of Clinical Laboratories, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Melissa
authors.initials: M
authors.lastname: Pessin
authors.affiliation: Bone Marrow Transplant Service Department of Medicine.
authors.forename: Koen
authors.initials: K
authors.lastname: van Besien
authors.affiliation: Department of Medicine Department of Bone Marrow Transplant Service Department of Medicine.
authors.forename: Miguel-Angel
authors.initials: MA
authors.lastname: Perales
authors.affiliation: Department of Medicine Department of Bone Marrow Transplant Service Department of Medicine.
authors.forename: Sergio
authors.initials: S
authors.lastname: Giralt
authors.affiliation: Department of Medicine Department of Infection Control Department of Infectious Disease Service Department of Medicine.
authors.forename: Kent
authors.initials: K
authors.lastname: Sepkowitz
authors.affiliation: Department of Medicine Department of Infectious Disease Service Department of Medicine.
authors.forename: Genovefa A
authors.initials: GA
authors.lastname: Papanicolaou
authors.affiliation: Infectious Diseases Department of Medicine.
authors.forename: Rosemary
authors.initials: R
authors.lastname: Soave
authors.affiliation: Department of Medicine Department of Infection Control Department of Infectious Disease Service Department of Medicine.
authors.forename: Mini
authors.initials: M
authors.lastname: Kamboj
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D042241:Early Diagnosis; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009519:New York City / Q000453:epidemiology; D018512:Parasitemia; D016133:Polymerase Chain Reaction; D065129:Pre-Exposure Prophylaxis; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014122:Toxoplasma / Q000235:genetics / Q000302:isolation & purification*; D014123:Toxoplasmosis / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000469:parasitology; D066027:Transplant Recipients
keywords: CD34+ selected; T-cell depleted; reactivation; stem cell transplant; toxoplasmosis