title: The Structural Relationship between Iterative and Modular PKSs.
abstract: Recent work has characterized the architecture of a highly-reducing iterative polyketide synthase (PKS), the mycocerosic acid synthase (MAS) (Herbst et al., 2016). Beyond sharing a structural similarity with the mammalian fatty acid synthase (FAS), the authors argue that the MAS architecture is representative of some PKS modules.
authors.affiliation: Departments of Molecular Biosciences and Chemistry, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: adriankc@utexas.edu.
authors.forename: Adrian T
authors.initials: AT
authors.lastname: Keatinge-Clay
mesh_terms: D000217:Acyltransferases; D000818:Animals; D048630:Polyketide Synthases
chemical_list: D048630:Polyketide Synthases; D000217:Acyltransferases; C044110:mycocerosic acid synthase