title: Otoacoustic emissions in newborns with mild and moderate perinatal hypoxia.
abstract: Introduction Severe neonatal hypoxia (as evidenced by the Apgar value) is currently considered the only risk for hearing loss. Hypoxia is one of the most common causes of injury and cell death. The deprivation of oxygen in mild or moderate cases of hypoxia, although smaller, occurs and could cause damage to the auditory system. Objective To investigate the amplitude of otoacoustic emissions in neonates at term with mild to moderate hypoxia and no risk for hearing loss. Methods We evaluated 37 newborns, divided into two groups: a control group of 25 newborns without hypoxia and a study group of 12 newborns with mild to moderate hypoxia. TEOAE and DPOAE were investigated in both groups. Results The differences between groups were statistically significant in the amplitude of DPOAE at the frequencies of 1000, 2800, 4000 and 6000 Hz. In TEOAE, statistically significant differences were found in all tested frequency bands. OAE of the study group were lower than those in the control group. Conclusion Although the occurrence of mild and moderate neonatal hypoxia is not considered a risk factor for hearing loss, deprivation of minimum oxygen during neonatal hypoxia seems to interfere in the functioning of the outer hair cells and, consequently, alter the response level of otoacoustic emissions. Thus, hese children need longitudinal follow-up in order to identify the possible impact of these results on language acquisition and future academic performance.
authors.affiliation: Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, SP, Brasil.
authors.forename: Juliana Neves
authors.initials: JN
authors.lastname: Leite
authors.affiliation: Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, SP, Brasil.
authors.forename: Vinicius Souza
authors.initials: VS
authors.lastname: Silva
authors.affiliation: Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, SP, Brasil.
authors.forename: Byanka Cagnacci
authors.initials: BC
authors.lastname: Buzo
mesh_terms: D000704:Analysis of Variance; D001034:Apgar Score; D016022:Case-Control Studies; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D006198:Hair Cells, Auditory / Q000502:physiology; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D006801:Humans; D000860:Hypoxia / Q000150:complications* / Q000503:physiopathology*; D007231:Infant, Newborn; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D012016:Reference Values; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors