title: Cutaneous Markers of Systemic Disease in the Lower Extremity.
abstract: The skin of the lower extremity can be a helpful diagnostic tool for systemic disease. Diabetes, renal disease, genetic disorders, and even cancer can have cutaneous manifestations in the legs and feet; moreover, proper diagnosis can facilitate earlier treatment of these diseases and not only clear up the skin symptoms but also bring about resolution of the systemic disease causing them. Although not comprehensive, this article discusses many of these disorders presenting with integumentary manifestations in the lower extremities. Where appropriate, it also enumerates the treatments involved, both systemic and localized.
authors.affiliation: Private Practice, Impression Foot & Ankle, 5656 South Power Road, Suite 124, Gilbert, AZ 85295, USA. Electronic address: JosephVellaDPM@gmail.com.
authors.forename: Joseph
authors.initials: J
authors.lastname: Vella
mesh_terms: D002318:Cardiovascular Diseases / Q000150:complications; D048909:Diabetes Complications / Q000150:complications; D005533:Foot Dermatoses / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007674:Kidney Diseases / Q000150:complications; D007868:Leg Dermatoses / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D013959:Thyroid Diseases / Q000150:complications
keywords: Cutaneous manifestations; Lower extremity; Skin disorders; Systemic disease