title: Senegenin inhibits neuronal apoptosis after spinal cord contusion injury.
abstract: Senegenin has been shown to inhibit neuronal apoptosis, thereby exerting a neuroprotective effect. In the present study, we established a rat model of spinal cord contusion injury using the modified Allen's method. Three hours after injury, senegenin (30 mg/g) was injected into the tail vein for 3 consecutive days. Senegenin reduced the size of syringomyelic cavities, and it substantially reduced the number of apoptotic cells in the spinal cord. At the site of injury, Bax and Caspase-3 mRNA and protein levels were decreased by senegenin, while Bcl-2 mRNA and protein levels were increased. Nerve fiber density was increased in the spinal cord proximal to the brain, and hindlimb motor function and electrophysiological properties of rat hindlimb were improved. Taken together, our results suggest that senegenin exerts a neuroprotective effect by suppressing neuronal apoptosis at the site of spinal cord injury.
authors.affiliation: Department of Orthopedics, Nankai Hospital, Tianjin, China.
authors.forename: Shu-Quan
authors.initials: SQ
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, the Second Hospital of Jilin University, Changchun, Jilin Province, China.
authors.forename: Min-Fei
authors.initials: MF
authors.lastname: Wu
authors.affiliation: Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Gu
authors.affiliation: Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China.
authors.forename: Jia-Bei
authors.initials: JB
authors.lastname: Liu
authors.affiliation: Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China.
authors.forename: Qing-San
authors.initials: QS
authors.lastname: Zhu
authors.affiliation: Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China; Scientific Research Center, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, China.
authors.forename: Jin-Lan
authors.identifier: 0000-0002-8777-4783
authors.initials: JL
authors.lastname: Jiang
keywords: apoptosis; electrophysiology; motor function; nerve regeneration; neural regeneration; senegenin; spinal cord contusion; thinleaf milkwort root