title: Estimation of fiber orientations using neighborhood information.
abstract: Data from diffusion magnetic resonance imaging (dMRI) can be used to reconstruct fiber tracts, for example, in muscle and white matter. Estimation of fiber orientations (FOs) is a crucial step in the reconstruction process and these estimates can be corrupted by noise. In this paper, a new method called Fiber Orientation Reconstruction using Neighborhood Information (FORNI) is described and shown to reduce the effects of noise and improve FO estimation performance by incorporating spatial consistency. FORNI uses a fixed tensor basis to model the diffusion weighted signals, which has the advantage of providing an explicit relationship between the basis vectors and the FOs. FO spatial coherence is encouraged using weighted ℓ1-norm regularization terms, which contain the interaction of directional information between neighbor voxels. Data fidelity is encouraged using a squared error between the observed and reconstructed diffusion weighted signals. After appropriate weighting of these competing objectives, the resulting objective function is minimized using a block coordinate descent algorithm, and a straightforward parallelization strategy is used to speed up processing. Experiments were performed on a digital crossing phantom, ex vivo tongue dMRI data, and in vivo brain dMRI data for both qualitative and quantitative evaluation. The results demonstrate that FORNI improves the quality of FO estimation over other state of the art algorithms.
authors.affiliation: Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China. Electronic address: chuyang.ye@nlpr.ia.ac.cn.
authors.forename: Chuyang
authors.initials: C
authors.lastname: Ye
authors.affiliation: Department of Radiology, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Jiachen
authors.initials: J
authors.lastname: Zhuo
authors.affiliation: Department of Radiology, University of Maryland School of Medicine, Baltimore, MD, USA.
authors.forename: Rao P
authors.initials: RP
authors.lastname: Gullapalli
authors.affiliation: Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Prince
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology / Q000166:cytology / Q000000981:diagnostic imaging*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D014059:Tongue / Q000033:anatomy & histology / Q000166:cytology / Q000000981:diagnostic imaging*
keywords: Diffusion MRI; Fiber orientation estimation; Neighborhood information