title: The assignment of the configuration for α-hydroxy acid esters using a CEC strategy.
abstract: A simple and efficient (1)H NMR method for determining the absolute configuration of chiral α-hydroxy acid esters using a competing enantioselective conversion (CEC) strategy was developed. The α-hydroxy acid esters were acylated in the presence of Feng's chiral N,N'-dioxide-scandium(iii) complex, and the faster reaction was identified when one enantiomer of the chiral α-hydroxy acid ester was treated with both enantiomers of the ligand by NMR analysis of the reaction mixture without further purification. A mnemonic is presented to aid the assignment of the absolute configuration of the substrates.
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn.
authors.forename: Ruixue
authors.initials: R
authors.lastname: Peng
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Yuheng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wangbin
authors.initials: W
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng