title: Lessons from the Murine Models of West Nile Virus Infection.
abstract: West Nile virus (WNV), a mosquito-borne, single positive-stranded RNA virus, has been the leading cause of arboviral encephalitis in the U.S. and other parts of the world over the past decade. Up to 50 % of WNV convalescent patients were reported to have long-term neurological sequelae or chronic kidney diseases. However, there are neither antiviral drugs nor vaccines available for humans. The underlying mechanism of the long-term sequelae is not clearly understood either. Animal models have been an effective tool to investigate viral pathogenesis and host immunity in humans. Here, we will review several commonly used murine models of WNV infection.
authors.affiliation: Department of Microbiology & Immunology, University of Texas Medical Branch, Keiller 3.118B, Galveston, TX, 77555-0609, USA.
authors.forename: Brenna
authors.initials: B
authors.lastname: McGruder
authors.affiliation: Department of Immunology, National AIDS Research Institute, Pune, MH, 411026, India.
authors.forename: Vandana
authors.initials: V
authors.lastname: Saxena
authors.affiliation: Department of Microbiology & Immunology, University of Texas Medical Branch, Keiller 3.118B, Galveston, TX, 77555-0609, USA. ti1wang@utmb.edu.|Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA. ti1wang@utmb.edu.|Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX, 77555, USA. ti1wang@utmb.edu.
authors.forename: Tian
authors.initials: T
authors.lastname: Wang
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000209:etiology*; D009033:Culicidae / Q000821:virology; D004195:Disease Models, Animal; D006801:Humans; D007303:Insect Vectors / Q000821:virology; D051379:Mice; D051436:Renal Insufficiency, Chronic / Q000209:etiology*; D014901:West Nile Fever / Q000150:complications / Q000276:immunology* / Q000635:transmission; D014902:West Nile virus / Q000276:immunology / Q000472:pathogenicity*
keywords: Immunity; Infection; Mice; Pathogenesis; West Nile virus