title: Clinical manifestations and outcome of patients with human immunodeficiency virus infection at tertiary care teaching hospital.
abstract: BACKGROUND
  AIDS has become chronic illness which is well treated with antiretroviral therapy and management of opportunistic infections (OIs).
  
  
  OBJECTIVE
  The study clinical profile and outcome of human immunodeficiency virus (HIV) seropositive patients.
  
  
  METHODS
  This was retrospective observational study carried out over a period of 1 year (January 2011-December 2011). All HIV patients admitted in medicine ward, and ICU were enrolled. Statistical analysis was performed using SSPE statistical software trial version 11. The P< 0.05 was considered as statistically significant.
  
  
  RESULTS
  Of total 111 patients with a diagnosis of HIV/AIDS, 75 (67.56%) were male and 36 (32.43%) were female patients. A total 52 (46.84%) patients presented with respiratory manifestations, of them 23 (44.23%) had pulmonary tuberculosis (TB), 6 (11.53%) had tubercular effusion, and 3 (5.76%) had Pneumocystis jirovecii pneumonia. Respiratory manifestations including pulmonary TB were the most common presentation (P< 0.001). Total 27 (24.32%) patients were presented with the neurological manifestation of them 8 (29.62%) had a cerebro-vascular accident, 5 (18.51%) had cryptococcal meningitis, 4 (14.81%) had tubercular meningitis, and 1 (3.70%) had progressive multifocal leukoencephalopathy. Total 12 (38.70%) had acute gastroenteritis 6 (19.35%) had oral candidiasis, 8 (25%) had general tonic clonic seizure and 7 (21.87%) had pyrexia of unknown origin, 6 (18.75%) had septicemia, 6 (18.75%) had acute renal failure, and 6 (94.11%) had anemia. A total 11 (9.90%) patients succumbed.
  
  
  CONCLUSIONS
  Overall respiratory manifestations were the common presentation in a present cohort of HIV seropositive patients and TB was the most common OI and the cerebrovascular accident was the most common neurological manifestation.
authors.affiliation: Department of Medicine, Krishna Institute of Medical Sciences University, Karad, Satara, Maharashtra, India.
authors.forename: Virendra Chandrashekhar
authors.initials: VC
authors.lastname: Patil
authors.affiliation: Department of Microbiology, Krishna Institute of Medical Sciences University, Karad, Satara, Maharashtra, India.
authors.forename: Harsha V
authors.initials: HV
authors.lastname: Patil
keywords: Cryptococcal meningitis; Pneumocystis jirovecii; human immunodeficiency virus seropositive patients; opportunistic infections; progressive multifocal leucoencephalopathy; pulmonary tuberculosis