title: Nitro-Triarylmethyl Radical as Dual Oxygen and Superoxide Probe.
abstract: Superoxide radical is involved in numerous physiological and pathophysiological processes. Tetrathiatriarylmethyl (TAM) radicals are known to react with superoxide allowing measurement of superoxide production in biological media. We report the synthesis of a Nitro conjugated TAM radical showing a rate constant of 7 × 105M-1s-1which is two order of magnitude higher than other TAMs, allowing high sensitivity measurement of superoxide.
authors.affiliation: In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, 26506, USA. benoit.driesschaert@hsc.wvu.edu.|Department of Biochemistry, West Virginia University School of Medicine, 1 Medical Center Drive, P.O. Box 9142, Morgantown, WV, 26506, USA. benoit.driesschaert@hsc.wvu.edu.
authors.forename: Benoit
authors.initials: B
authors.lastname: Driesschaert
authors.affiliation: In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, 26506, USA.|Department of Biochemistry, West Virginia University School of Medicine, 1 Medical Center Drive, P.O. Box 9142, Morgantown, WV, 26506, USA.
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Bobko
authors.affiliation: In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, 26506, USA. valery.khramtsov@wvu.edu.|Department of Biochemistry, West Virginia University School of Medicine, 1 Medical Center Drive, P.O. Box 9142, Morgantown, WV, 26506, USA. valery.khramtsov@wvu.edu.
authors.forename: Valery V
authors.initials: VV
authors.lastname: Khramtsov
authors.affiliation: Davis Heart and Lung Research Institute, The Ohio State University/Wexner Medical Center, 460 West 12th Avenue, BRT 0390, Columbus, OH, 43210, USA. jay.zweier@osumc.edu.
authors.forename: Jay L
authors.initials: JL
authors.lastname: Zweier
mesh_terms: D055664:Electrochemical Techniques; D004578:Electron Spin Resonance Spectroscopy; D006863:Hydrogen-Ion Concentration; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry*; D010100:Oxygen / Q000032:analysis* / Q000737:chemistry; D012996:Solutions; D013481:Superoxides / Q000032:analysis* / Q000737:chemistry; D014320:Triphenylmethyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D014969:Xanthine Oxidase / Q000737:chemistry
chemical_list: D015335:Molecular Probes; D012996:Solutions; D014320:Triphenylmethyl Compounds; D014867:Water; D013481:Superoxides; D014969:Xanthine Oxidase; D010100:Oxygen
keywords: EPR; Oxygen; ROS; Superoxide; Trityl