title: Efficacy of the GemOx-R regimen leads to the identification of Oxaliplatin as a highly effective drug against Mantle Cell Lymphoma.
abstract: Mantle Cell Lymphoma (MCL) is an aggressive lymphoma subtype that accounts for 6-8% of non-Hodgkin lymphomas. The disease is mostly incurable and characterized by a continuous pattern of relapse. Major changes have recently been implemented in the management of MCL, but continuous relapses still mark this disease as a challenge for clinicians. We previously reported the efficacy of GemOx-R (Gemcitabine, Oxaliplatin and Rituximab) in patients with refractory and relapsing MCL. We present results for a larger series with longer follow-up and including high-risk frontline patients, showing an overall response rate of 83%. The efficacy of each component of GemOx-R was evaluated in a panel of MCL cell lines. Also, patient-derived primary cells were used in ex vivo experiments. The results show that oxaliplatin has a profound effect on cellular viability and is the most effective drug within this regimen. We further present synergistic efficacy of oxaliplatin combined with cytarabine in MCL cells. Interestingly, this synergistic effect was not seen when cisplatin and cytarabine were combined, indicating that among the platinum-derived agents oxaliplatin may be the preferred approach. Taken together our findings suggest that oxaliplatin alone or combined with cytarabine could constitute an alternative backbone for MCL regimens.
authors.affiliation: Cancer Cell Biology Group, Institut Universitari d'Investigació en Ciències de La Salut (IUNICS), Palma, Illes Balears, Spain.|Departament de Biologia Fonamental, Universitat de les Illes Balears, Palma, Illes Balears, Spain.|Institut de Investigació Sanitària de Palma (IdISPa), Palma, Illes Balears, Spain.
authors.forename: Antònia
authors.initials: A
authors.lastname: Obrador-Hevia
authors.affiliation: Cancer Cell Biology Group, Institut Universitari d'Investigació en Ciències de La Salut (IUNICS), Palma, Illes Balears, Spain.|Institut de Investigació Sanitària de Palma (IdISPa), Palma, Illes Balears, Spain.
authors.forename: Margalida
authors.initials: M
authors.lastname: Serra-Sitjar
authors.affiliation: MD Anderson Cancer Centre, Madrid, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Rodríguez
authors.affiliation: Cancer Cell Biology Group, Institut Universitari d'Investigació en Ciències de La Salut (IUNICS), Palma, Illes Balears, Spain.
authors.forename: Lamiae
authors.initials: L
authors.lastname: Belayachi
authors.affiliation: Institut de Investigació Sanitària de Palma (IdISPa), Palma, Illes Balears, Spain.|Service of Hematology, Son Espases University Hospital, Palma, Illes Balears, Spain.
authors.forename: Leyre
authors.initials: L
authors.lastname: Bento
authors.affiliation: Service of Hematology, Son Espases University Hospital, Palma, Illes Balears, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: García-Recio
authors.affiliation: Institut de Investigació Sanitària de Palma (IdISPa), Palma, Illes Balears, Spain.|Service of Hematology, Son Espases University Hospital, Palma, Illes Balears, Spain.
authors.forename: Jose María
authors.initials: JM
authors.lastname: Sánchez
authors.affiliation: Cancer Cell Biology Group, Institut Universitari d'Investigació en Ciències de La Salut (IUNICS), Palma, Illes Balears, Spain.|Departament de Biologia Fonamental, Universitat de les Illes Balears, Palma, Illes Balears, Spain.|Institut de Investigació Sanitària de Palma (IdISPa), Palma, Illes Balears, Spain.
authors.forename: Priam
authors.initials: P
authors.lastname: Villalonga
authors.affiliation: Institut de Investigació Sanitària de Palma (IdISPa), Palma, Illes Balears, Spain.|Service of Hematology, Son Espases University Hospital, Palma, Illes Balears, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gutiérrez
authors.affiliation: Cancer Cell Biology Group, Institut Universitari d'Investigació en Ciències de La Salut (IUNICS), Palma, Illes Balears, Spain.|Departament de Biologia Fonamental, Universitat de les Illes Balears, Palma, Illes Balears, Spain.|Institut de Investigació Sanitària de Palma (IdISPa), Palma, Illes Balears, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Fernández de Mattos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D004357:Drug Synergism; D005260:Female; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000077150:Oxaliplatin; D012008:Recurrence; D019233:Retreatment; D012189:Retrospective Studies; D000069283:Rituximab / Q000008:administration & dosage; D016879:Salvage Therapy; D016896:Treatment Outcome
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D003841:Deoxycytidine; D000069283:Rituximab
keywords: GemOx-R; cisplatin; cytarabine; mantle cell lymphoma; oxaliplatin