title: Lysine-specific histone demethylases in normal and malignant hematopoiesis.
abstract: The epigenetic control of gene expression is central to the development of the hematopoietic system and the execution of lineage-specific transcriptional programs. During the last 10 years, mounting evidence has implicated the family of lysine-specific histone demethylases as critical regulators of normal hematopoiesis, whereas their deregulation is found in a broad spectrum of hematopoietic malignancies. Here, we review recent findings on the role of these enzymes in normal and malignant hematopoiesis and highlight how aberrant epigenetic regulation facilitates hematopoietic cell transformation through subversion of cell fate and lineage commitment programs.
authors.affiliation: Cancer Epigenetics Laboratory, Department of Anatomy and Regenerative Biology, George Washington University, Washington DC, USA; George Washington University Cancer Center, School of Medicine and Health Sciences, George Washington University, Washington DC, USA. Electronic address: jandricovich@gwu.edu.
authors.forename: Jaclyn
authors.initials: J
authors.lastname: Andricovich
authors.affiliation: Cancer Epigenetics Laboratory, Department of Anatomy and Regenerative Biology, George Washington University, Washington DC, USA; Department of Physics, George Washington University, Washington DC, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Kai
authors.affiliation: Cancer Epigenetics Laboratory, Department of Anatomy and Regenerative Biology, George Washington University, Washington DC, USA; George Washington University Cancer Center, School of Medicine and Health Sciences, George Washington University, Washington DC, USA. Electronic address: atzatsos@gwu.edu.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Tzatsos
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000378:metabolism*; D006410:Hematopoiesis / Q000235:genetics*; D056466:Histone Demethylases / Q000235:genetics* / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D008745:Methylation; D015398:Signal Transduction
chemical_list: D006657:Histones; D056466:Histone Demethylases