title: Association of Sudden Sensorineural Hearing Loss With Vertebrobasilar Insufficiency.
abstract: Little is known about the association between sudden sensorineural hearing loss (SSNHL) and vertebrobasilar insufficiency (VBI).
  
  
  
  To explore the association between SSNHL and VBI.
  
  
  
  This investigation was a population-based, case-control study. Patients from January 1, 2000, to December 31, 2011, were retrospectively identified from the Taiwan National Health Insurance Research Database, which includes claims data on a random sample of 1 million people.
  
  
  
  Using propensity score matching on age and sex, patients were stratified at a 1:4 ratio into a study group comprising 5304 patients with a diagnosis of SSNHL and a control group comprising 21 216 patients. Those with a diagnosis of VBI before the index date (the date each patient was diagnosed as having SSNHL) in both groups were then identified. A conditional logistic regression model was used to estimate the adjusted odds ratios (ORs) and 95% CIs as a measure of the association between SSNHL and VBI.
  
  
  
  The study cohort comprised 26 520 patients. Their mean (SD) age was 51.3 (17.2) years, and 47.1% (12 500 of 26 520) were female. Vertebrobasilar insufficiency was diagnosed before the index date in 0.5% (26 of 5304) of patients with SSNHL and in 0.2% (38 of 21 216) of controls without SSNHL. After adjusting for comorbid medical disorders, patients with SSNHL were more likely than controls to have had VBI (OR, 1.76; 95% CI, 1.02-3.04). There were no significant differences in the prevalence of VBI among male patients with SSNHL vs male controls (OR, 1.72; 95% CI, 0.87-3.40) or among female patients with SSNHL vs female controls (OR, 1.86; 95% CI, 0.76-4.59).
  
  
  
  Patients with VBI appear to be at increased risk of developing SSNHL. Further research is needed to investigate the association among the severity of VBI, the risk of SSNHL, and the pattern of the audiometric curve.
authors.affiliation: Department of Otolaryngology, Taipei City Hospital, Taipei, Taiwan.
authors.forename: Yin-Hsuan
authors.initials: YH
authors.lastname: Hsu
authors.affiliation: Department of Teaching and Research, Taipei City Hospital, Taipei, Taiwan3Department of Public Health, Institute of Public Health, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Hsiao-Yun
authors.initials: HY
authors.lastname: Hu
authors.affiliation: Department of Otolaryngology, Taipei City Hospital, Taipei, Taiwan.
authors.forename: Yu-Chwen
authors.initials: YC
authors.lastname: Chiu
authors.affiliation: Department of Otolaryngology, College of Medicine, Taipei Medical University, Taipei, Taiwan5Department of Otolaryngology, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Fei-Peng
authors.initials: FP
authors.lastname: Lee
authors.affiliation: Department of Otolaryngology, Taipei City Hospital, Taipei, Taiwan4Department of Otolaryngology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Hung-Meng
authors.initials: HM
authors.lastname: Huang
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D003639:Hearing Loss, Sudden / Q000209:etiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013624:Taiwan; D014715:Vertebrobasilar Insufficiency / Q000150:complications*