title: Autophagy Determines the Path on the TRAIL to Death.
abstract: Macroautophagy facilitates degradation of cellular constituents and can positively or negatively affect cell death depending on the context. In this issue of Developmental Cell, Goodall and colleagues (2016) add to this complexity by showing that autophagy regulators can determine not only cell viability, but also the mechanism by which cells die.
authors.affiliation: Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
authors.forename: Jun-Ichi
authors.initials: JI
authors.lastname: Sakamaki
authors.affiliation: Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. Electronic address: k.ryan@beatson.gla.ac.uk.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Ryan
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D000071182:Autophagosomes / Q000378:metabolism; D001343:Autophagy / Q000187:drug effects*; D006801:Humans; D008954:Models, Biological; D009336:Necrosis; D015398:Signal Transduction; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000494:pharmacology*
chemical_list: D053221:TNF-Related Apoptosis-Inducing Ligand