title: Oxidative Stress Measurement and Prediction of Epileptic Seizure in Children and Adults With Severe Motor and Intellectual Disabilities.
abstract: BACKGROUND
  The medical care of severe motor and intellectual disabilities (SMID) depends on the empirical medical care. Epileptic seizure specific to SMID is difficult to suppress using anti-epileptic drugs, and its tendency to persist for long periods poses an issue. The present study was undertaken to evaluate the relationship between epileptic seizure in cases with SMID and oxidative stress in the living body by examining endogenous antioxidants, the degree of oxidation (reactive oxygen metabolites (d-ROMs)), and the biological antioxidant potential (BAP) as indicators.
  
  
  METHODS
  Target patients were 43 SMID epilepsy patients. Blood was sampled before breakfast and medication. As for the specimen, d-ROMs and BAP were measured using the free radical analyzer.
  
  
  RESULTS
  The present study did not reveal any correlation between endogenous antioxidants (albumin) and the frequency of epileptic seizures. On the other hand, d-ROMs were correlated with the frequency of epileptic seizure. In particular, strong correlations between the frequency of epileptic seizures and the d-ROMs/BAP ratio as well as the BAP/d-ROMs ratio were noted.
  
  
  CONCLUSIONS
  These results indicate that the use of d-ROMs and BAP as biomarkers can provide a tool for predicting the prognosis of epileptic seizures in patients with SMID.
authors.affiliation: Tokushima Bunri University, Graduate School of Pharmaceutical Sciences, Tokushima, Japan; Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People With Disabilities, Tokushima, Japan.
authors.forename: Masahito
authors.initials: M
authors.lastname: Morimoto
authors.affiliation: Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People With Disabilities, Tokushima, Japan.
authors.forename: Shigeko
authors.initials: S
authors.lastname: Satomura
authors.affiliation: Japanese Red Cross Tokushima Hinomine Rehabilitation Center for People With Disabilities, Tokushima, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hashimoto
authors.affiliation: Tokushima Bunri University, Graduate School of Pharmaceutical Sciences, Tokushima, Japan.
authors.forename: Etsuro
authors.initials: E
authors.lastname: Ito
authors.affiliation: Tokushima Bunri University, Graduate School of Pharmaceutical Sciences, Tokushima, Japan.
authors.forename: Shojiro
authors.initials: S
authors.lastname: Kyotani
keywords: Biomarker; Epilepsy; Motor and intellectual disabilities; Oxidative stress; Seizure; d-ROMs test