title: Renal manifestations of human brucellosis: First report of minimal change disease.
abstract: Human brucellosis is considered a great example of the complexity of clinical manifestations possibly affecting multiple organs or systems. Renal manifestations of human brucellosis have been documented in few case reports and one case series. Herein, we present a case of Nephrotic syndrome (NS) due to minimal change disease in the course of acute brucellosis. A 53-year-old male farmer was admitted to our department with acute brucellosis and NS. Renal biopsy revealed minimal change disease. Combined treatment with prednisone (1 mg/kg), rifampicin (600 mg/day), and doxycycline (200 mg/day) was initiated. Complete remission of NS was achieved at the end of the fourth week. One year later, the patient remained in complete remission of NS without any sign of relapse of brucellosis.
authors.affiliation: Department of Nephrology, General Hospital of Edessa, Edessa, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Sabanis
authors.affiliation: Department of Nephrology, General Hospital of Edessa, Edessa, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Gavriilaki
authors.affiliation: Department of Nephrology, General Hospital of Edessa, Edessa, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Paschou
authors.affiliation: Department of Nephrology, General Hospital of Edessa, Edessa, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Tsotsiou
authors.affiliation: Postgraduate Program, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Asterios
authors.initials: A
authors.lastname: Kalaitzoglou
authors.affiliation: Department of Nephrology, General Hospital of Edessa, Edessa, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Kavlakoudis
authors.affiliation: Department of Nephrology, General Hospital of Edessa, Edessa, Greece.
authors.forename: Sotirios
authors.initials: S
authors.lastname: Vasileiou
mesh_terms: D002006:Brucellosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009402:Nephrosis, Lipoid; D009404:Nephrotic Syndrome