title: [Predictive factors and prognostic consequences of perioperative complications of radical cystectomies for urothelial carcinoma in patients of 80 years or more].
abstract: OBJECTIVE
  To define the predictive factors and the prognostic consequences of perioperative complications occurrence while radical cystectomies for urothelial carcinoma treatment in patients older than 80 years.
  
  
  METHODS
  Retrospective analysis of clinical and biological preoperative data and outcome of eighty patients of 80 years or more, treated with radical cystectomy between 1990 and 2010 in one centre. Perioperative complications were graded according to the classification from Clavien-Dindo.
  
  
  RESULTS
  Twenty-eight patients (35%) had a single perioperative complication and nineteen (24%) had multiple (≥2) perioperative complications. Overall survival of patients with multiple perioperative complications was significantly lower than that of patients who had no complications (Log-rank P=0.0004). The occurrence of multiple perioperative complications was associated with Charlson and ASA scores, with pelvic irradiation and induction chemotherapy histories. However, in multivariate analysis, only the existence of respiratory comorbidity was an independent risk factor for the occurrence of multiple perioperative complications.
  
  
  CONCLUSIONS
  The occurrence of multiple perioperative complications was associated with reduced overall survival in elderly patients after radical cystectomy. The existence of respiratory comorbidity was the only independent risk factor for the occurrence of multiple perioperative complications.
  
  
  METHODS
  5.
authors.affiliation: Service d'urologie, hôpital Foch, université de Versailles-Saint-Quentin-en-Yvelines, 40, rue Worth, 92150 Suresnes, France.
authors.forename: T
authors.initials: T
authors.lastname: Chanu
authors.affiliation: Service d'urologie, hôpital Foch, université de Versailles-Saint-Quentin-en-Yvelines, 40, rue Worth, 92150 Suresnes, France. Electronic address: y.neuzillet@hopital-foch.org.
authors.forename: Y
authors.initials: Y
authors.lastname: Neuzillet
authors.affiliation: Service d'urologie, hôpital Foch, université de Versailles-Saint-Quentin-en-Yvelines, 40, rue Worth, 92150 Suresnes, France.
authors.forename: M
authors.initials: M
authors.lastname: Butreau
authors.affiliation: Service d'urologie, hôpital Foch, université de Versailles-Saint-Quentin-en-Yvelines, 40, rue Worth, 92150 Suresnes, France.
authors.forename: C
authors.initials: C
authors.lastname: Bach
authors.affiliation: Service d'urologie, hôpital Foch, université de Versailles-Saint-Quentin-en-Yvelines, 40, rue Worth, 92150 Suresnes, France.
authors.forename: M
authors.initials: M
authors.lastname: Rouanne
authors.affiliation: Service d'urologie, hôpital Foch, université de Versailles-Saint-Quentin-en-Yvelines, 40, rue Worth, 92150 Suresnes, France.
authors.forename: T
authors.initials: T
authors.lastname: Lebret
mesh_terms: D000369:Aged, 80 and over; D015653:Cystectomy; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000601:surgery*
keywords: Complications; Cystectomie; Cystectomy; Facteurs prédictifs; Gerontology; Gérontologie; Predictive factors; Prognosis; Pronostic