title: Environment-driven somatic mosaicism in brain disorders.
abstract: The identification of somatic mosaicism in the brain lends a new perspective to our understanding of the role of gene and environment interactions in psychiatric disease risk. Somatic mutations, such as retrotransposon insertions, that are precipitated by modern environmental factors may alter neuronal function and neurological traits, increasing the societal prevalence of mental disorders.
authors.affiliation: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
authors.forename: Tracy A
authors.initials: TA
authors.lastname: Bedrosian
authors.affiliation: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Linker
authors.affiliation: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA. gage@salk.edu.
authors.forename: Fred H
authors.initials: FH
authors.lastname: Gage
mesh_terms: D001927:Brain Diseases / Q000235:genetics*; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D009030:Mosaicism; D016254:Mutagenesis, Insertional; D009154:Mutation; D018626:Retroelements / Q000502:physiology*
chemical_list: D018626:Retroelements