title: Sickle cell anemia in Brazil: personal, medical and endodontic patterns.
abstract: Sickle cell anemia (SCA) is the most prevalent genetic disease worldwide. Recurrent vaso-occlusive infarcts predispose SCA patients to infections, which are the primary causes of morbidly and mortality. This study aimed to evaluate the relationship between SCA and endodontic diseases. Personal information, medical data (hematological indices, virologic testing, blood transfusions, medications received, splenectomy) and information on the need for endodontic treatment were obtained from SCA patients who were registered and followed up by the Fundação Hemominas, Minas Gerais, Brazil.These data were compared with the need for root canal treatment in SCA patients. One hundred eight patients comprised the studied population, and the rate of the need for endodontic therapy was 10.2%. Among the medical data, a significant difference was observed for eosinophil (p = 0.045) counts and atypical lymphocyte counts (p = 0.036) when the groups (with and without the need for endodontic treatment) were compared. Statistical relevance was observed when comparing the patients with and without the need for root canal therapy concerned eosinophil counts and atypical lymphocyte counts. The differences in statistical medical data, observed between the groups suggest that both parameters are naturally connected to the stimulation of the immune system that can occur in the presence of root canal infections and that can be harmful to SCA individuals.
authors.affiliation: Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Restorative Dentistry, Belo Horizonte, MG, Brazil.
authors.forename: Shirlene Barbosa Pimentel
authors.initials: SB
authors.lastname: Ferreira
authors.affiliation: Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Restorative Dentistry, Belo Horizonte, MG, Brazil.
authors.forename: Warley Luciano Fonseca
authors.initials: WL
authors.lastname: Tavares
authors.affiliation: Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Restorative Dentistry, Belo Horizonte, MG, Brazil.
authors.forename: Marco Aurélio Camargo da
authors.initials: MA
authors.lastname: Rosa
authors.affiliation: Fundação Universidade de Itaúna - FUI, School of Dentistry, Itaúna, MG, Brazil.
authors.forename: Luciana Carla Neves de
authors.initials: LC
authors.lastname: Brito
authors.affiliation: Universidade Federal de Minas Gerais - UFMG, Biological Sciences Institute, Department of Immunology and Biochemistry, Belo Horizonte, MG, Brazil.
authors.forename: Leda Quércia
authors.initials: LQ
authors.lastname: Vieira
authors.affiliation: Universidade Estadual de Minas Gerais - UNIMONTES, Montes Claros School of Dentistry, Montes Claros, MG, Brazil.
authors.forename: Hercílio
authors.initials: H
authors.lastname: Martelli
authors.affiliation: Universidade Federal de Minas Gerais - UFMG, School of Dentistry, Department of Restorative Dentistry, Belo Horizonte, MG, Brazil.
authors.forename: Antônio Paulino
authors.initials: AP
authors.lastname: Ribeiro
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D000986:Antisickling Agents / Q000627:therapeutic use; D001803:Blood Transfusion / Q000706:statistics & numerical data; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003788:Dental Pulp Diseases / Q000209:etiology* / Q000628:therapy; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D020380:Needs Assessment / Q000706:statistics & numerical data*; D012390:Root Canal Therapy / Q000706:statistics & numerical data*; D012698:Serologic Tests; D013156:Splenectomy; D014803:Vitamin B Complex / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000986:Antisickling Agents; D014803:Vitamin B Complex; D005492:Folic Acid; D006918:Hydroxyurea