title: Evidence-Based Management Guidelines on Peyronie's Disease.
abstract: Despite recent advances in our knowledge and treatment strategies in Peyronie's Disease (PD), much remained unknown about this disease.
  
  
  
  To provide a clinical framework and key guideline statements to assist clinicians in an evidence-based management of PD.
  
  
  
  A systematic literature search was conducted to identify published literature relevant to PD. The search included all relevant articles published up to June 2015, including preclinical studies and published guidelines. References used in the text were assessed according to their level of evidence, and guideline recommendations were graded based on the Oxford Centre for Evidence-Based Medicine Levels of Evidence. Owing to the paucity of larger series and randomized placebo-controlled trials with regard to surgical intervention, guideline statements are provided as clinical principle or expert opinion.
  
  
  
  This literature was discussed at a panel meeting, and selected articles with the highest evidence available were used to create consensus guideline statements for the Fourth International Consultation on Sexual Medicine guidelines on PD.
  
  
  
  In addition to existing Third International Consultation on Sexual Medicine guidelines on PD, seven new summary recommendations were created.
  
  
  
  A greater understanding of the scientific basis of PD is greatly needed to address our understanding of the pathophysiology, clinical epidemiology, psychosocial, and diagnostic assessment as well as treatment strategies.
authors.affiliation: Department of Urology, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD, Australia; AndroUrology Centre, St. Andrew's War Memorial Hospital, Brisbane, QLD, Australia. Electronic address: ericchg@hotmail.com.
authors.forename: Eric
authors.initials: E
authors.lastname: Chung
authors.affiliation: Institute of Urology, University College London Hospital, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Ralph
authors.affiliation: Department of Urology, Istanbul Faculty of Medicine, Istanbul, Turkey.
authors.forename: Ates
authors.initials: A
authors.lastname: Kagioglu
authors.affiliation: Institute of Urology, University College London Hospital, London, UK.
authors.forename: Guilio
authors.initials: G
authors.lastname: Garaffa
authors.affiliation: Urology Department, Hamad General Hospital, Doha, Qatar.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Shamsodini
authors.affiliation: James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors.forename: Trinity
authors.initials: T
authors.lastname: Bivalacqua
authors.affiliation: Instituto H. Ellis and Department of Urology, Ipiranga Hospital, Sao Paulo, Brazil.
authors.forename: Sidney
authors.initials: S
authors.lastname: Glina
authors.affiliation: Department of Urology, Cleveland Clinic Florida, Weston, FL, USA.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Hakim
authors.affiliation: Division of Urology, UMDNJ-Robert Wood Johnson Medical School, Newark, NJ, USA.
authors.forename: Hossein
authors.initials: H
authors.lastname: Sadeghi-Nejad
authors.affiliation: Department of Urology, Mayo Clinic, Jacksonville, FL, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Broderick
mesh_terms: D019317:Evidence-Based Medicine; D006801:Humans; D008297:Male; D010411:Penile Induration / Q000601:surgery / Q000628:therapy*; D017410:Practice Guidelines as Topic
keywords: Clinical Evidence; Management Guideline; Penile Surgery; Peyronie's Disease; Summary Recommendation; Treatment Outcomes