title: Vitamin D Repletion in Korean Postmenopausal Women with Osteoporosis.
abstract: OBJECTIVE
  Up to 71% of South Korean postmenopausal women have vitamin D deficiency {serum 25-hydroxyvitamin D [25(OH) D] level <50 nmol/L}. Data on vitamin D supplementation was collected during the screening phase of an efficacy/safety study of denosumab in Korean postmenopausal women with osteoporosis. This report describes the effect of vitamin D supplementation on repletion to 25(OH)D levels ≥50 nmol/L in Korean postmenopausal women with osteoporosis.
  
  
  METHODS
  Vitamin D levels of Korean postmenopausal women (60-90 years old) were measured by extracting 25(OH)D₂ and 25(OH)D₃ from serum samples via protein precipitation and using liquid chromatography with tandem mass spectrometry detection. Calibration curves were constructed from the mass chromatograms to obtain total vitamin D levels. Subjects with serum 25(OH)D levels <50 nmol/L were supplemented with 1000 IU of vitamin D tablets during the 2.5-month-long screening period. Dose, frequency, and duration were determined by the investigator. If repletion was achieved (≥50 nmol/L) on retest, subjects were eligible to be rescreened for study entry.
  
  
  RESULTS
  Of 371 subjects screened, 191 (52%) required vitamin D supplementation, and 88% (168 of 191) were successfully repleted. More than half of the subjects (58%) who were successfully repleted received doses of 2000 IU daily. The mean time to successful repletion was 31 days (standard deviation 8.4 days; range 11-48 days).
  
  
  CONCLUSIONS
  Supplementation with daily median doses of 2000 IU vitamin D successfully repleted 88% of Korean postmenopausal women with osteoporosis within 48 days to a serum vitamin D level of 50 nmol/L.
authors.affiliation: Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Yoon Sok
authors.initials: YS
authors.lastname: Chung
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Dong Jin
authors.initials: DJ
authors.lastname: Chung
authors.affiliation: Department of Endocrinology and Metabolism, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
authors.forename: Moo Il
authors.initials: MI
authors.lastname: Kang
authors.affiliation: Department of Endocrinology and Metabolism, Pusan National University Hospital, Busan, Korea.
authors.forename: In Ju
authors.initials: IJ
authors.lastname: Kim
authors.affiliation: Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Koh
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Yong Ki
authors.initials: YK
authors.lastname: Min
authors.affiliation: Department of Family Medicine, Cheil General Hospital, College of Medicine, Kwandong University, Seoul, Korea.
authors.forename: Han Jin
authors.initials: HJ
authors.lastname: Oh
authors.affiliation: Department of Orthopedic Surgery, Kyungpook National University Hospital, Daegu, Korea.
authors.forename: Il Hyung
authors.initials: IH
authors.lastname: Park
authors.affiliation: GlaxoSmithKline, Seoul, Korea, Korea.
authors.forename: Yil Seob
authors.initials: YS
authors.lastname: Lee
authors.affiliation: GlaxoSmithKline, Collegeville, PA, USA. barbara.g.kravitz@gsk.com.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kravitz
authors.affiliation: GlaxoSmithKline, Collegeville, PA, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Waterhouse
authors.affiliation: GlaxoSmithKline, Collegeville, PA, USA.
authors.forename: Lorraine A
authors.initials: LA
authors.lastname: Fitzpatrick
authors.affiliation: GlaxoSmithKline, Collegeville, PA, USA.
authors.forename: Antonio
authors.initials: A
authors.lastname: Nino
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications* / Q000188:drug therapy / Q000208:ethnology; D017698:Postmenopause / Q000097:blood; D056910:Republic of Korea; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000175:diagnosis / Q000188:drug therapy* / Q000208:ethnology
chemical_list: D050071:Bone Density Conservation Agents; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Korean; Vitamin D; osteoporosis; postmenopause