title: Effect of Polylysine on Scrapie Prion Protein Propagation in Spleen during Asymptomatic Stage of Experimental Prion Disease in Mice.
abstract: Prion diseases are incurable neurodegenerative disorders. Our previous study demonstrated that polylysine was effective in prolonging the incubation period in a rodent model and in alleviating the scrapie prion protein (PrP(Sc)) burden in the brain at the terminal stage of the disease. Here, we report that intraperitoneal administration of polylysine suppresses the accumulation of prions in the spleen during the early stages of the disease. This study supports the congruence of PrP(Sc) inhibition by polylysine in both the spleen and brain.
authors.affiliation: Sander-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, KY 40536-0230, USA.
authors.forename: William B
authors.initials: WB
authors.lastname: Titlow
authors.affiliation: Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan 15588, Republic of Korea.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Waqas
authors.affiliation: Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan 15588, Republic of Korea.
authors.forename: Jihyun
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
authors.forename: Jae Youl
authors.initials: JY
authors.lastname: Cho
authors.affiliation: Department of Life Science, Gachon University, Seongnam 13120, Republic of Korea.
authors.forename: Sang Yeol
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Institute of Pharmaceutical Technology, Hanyang University, Ansan 15588, Republic of Korea.
authors.forename: Dae-Hwan
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Sander-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, KY 40536-0230, USA.|Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan 15588, Republic of Korea.|Institute of Pharmaceutical Technology, Hanyang University, Ansan 15588, Republic of Korea.|Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY 40536-0298, USA.
authors.forename: Chongsuk
authors.initials: C
authors.lastname: Ryou
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D004195:Disease Models, Animal; D051379:Mice; D011107:Polylysine / Q000737:chemistry*; D018620:PrPSc Proteins / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D017096:Prion Diseases / Q000378:metabolism*; D013154:Spleen / Q000737:chemistry* / Q000378:metabolism
chemical_list: D018620:PrPSc Proteins; D011107:Polylysine
keywords: PrPSc; Prion; animal model; brain; polylysine; spleen