title: Neonatal Mortality, Vesicular Lesions and Lameness Associated with Senecavirus A in a U.S. Sow Farm.
abstract: A 300-sow farrow-to-finish swine operation in the United States experienced a sudden and severe increase in mortality in neonatal piglets with high morbidity followed by vesicular lesions on the snout and feet of adult females and males. Affected live piglets were submitted for diagnostic investigation. Samples tested polymerase chain reaction (PCR) negative for foot-and-mouth disease virus, porcine delta coronavirus, porcine epidemic diarrhoea virus, porcine rotavirus types A, B and C, transmissible gastroenteritis virus, and porcine reproductive and respiratory syndrome virus. Senecavirus A (SV-A) formerly known as Seneca Valley virus was detected by real-time reverse-transcription polymerase chain reaction (rRT-PCR) from serum, skin and faeces of piglets and from serum and faeces of sows. SV-A was isolated in cell culture from piglet samples. SV-A VP1 gene region sequencing from piglet tissues was also successful. A biosecurity and disease entry evaluation was conducted and identified potential biosecurity risks factors for the entry of new pathogens into the operation. This is the first case report in the United States associating SV-A with a clinical course of severe but transient neonatal morbidity and mortality followed by vesicular lesions in breeding stock animals. Veterinarians and animal caretakers must remain vigilant for vesicular foreign animal diseases and report suspicious clinical signs and lesions to state animal health authorities for diagnostic testing and further investigation.
authors.affiliation: Swine Medicine Education Center, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
authors.forename: P
authors.initials: P
authors.lastname: Canning
authors.affiliation: Swine Medicine Education Center, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Canon
authors.affiliation: Swine Medicine Education Center, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Bates
authors.affiliation: Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
authors.forename: K
authors.initials: K
authors.lastname: Gerardy
authors.affiliation: Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
authors.forename: D C L
authors.initials: DC
authors.lastname: Linhares
authors.affiliation: Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
authors.forename: P E
authors.initials: PE
authors.lastname: Piñeyro
authors.affiliation: Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Schwartz
authors.affiliation: Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Yoon
authors.affiliation: Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Rademacher
authors.affiliation: Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Holtkamp
authors.affiliation: Swine Medicine Education Center, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
authors.forename: L
authors.initials: L
authors.lastname: Karriker
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000072480:Farms; D005243:Feces / Q000821:virology*; D005260:Female; D007794:Lameness, Animal / Q000821:virology*; D008297:Male; D010849:Picornaviridae / Q000235:genetics; D010850:Picornaviridae Infections / Q000401:mortality / Q000662:veterinary*; D060888:Real-Time Polymerase Chain Reaction; D013552:Swine; D013553:Swine Diseases / Q000401:mortality / Q000821:virology*; D014481:United States
keywords: Seneca Valley virus; Senecavirus A; lameness; neonatal mortality; swine; vesicular disease