title: Alterations in antioxidant and oxidant status of children after on-pump surgery for cyanotic and acyanotic congenital heart diseases.
abstract: OBJECTIVE
  Oxidative stress refers to an imbalance between reactive oxidative species and antioxidants. In this case-controlled, prospective, observational study, we investigated the total oxidant status, total antioxidant status, oxidative stress index, and albumin and C-reactive protein levels of children with cyanotic and acyanotic congenital heart diseases who had undergone on-pump cardiac surgery.
  
  
  METHODS
  The study groups consisted of 60 patients with congenital heart disease, who were operated under cardiopulmonary bypass, and a control group of 30 healthy individuals. The patients were classified into two groups. Among them, one was a patient group that consisted of 30 patients with acyanotic congenital heart disease and the other group consisted of 30 patients with cyanotic congenital heart disease. In the patient groups, blood samples were collected before surgery and at one and 24 hours following surgery. In control groups, blood samples were collected once during hospital admission.
  
  
  RESULTS
  No statistically significant differences were found between the groups in terms of baseline total oxidant status, total antioxidant status, and oxidative stress index values. Regarding the postoperative first-hour and 24-hour total oxidant status and total antioxidant status levels as well as oxidative stress index values, there were no significant differences between the groups, except for an increase in total antioxidant status levels (p=0.002) 24 hours after surgery in cyanotic patients.
  
  
  CONCLUSIONS
  There was no difference between oxidative stress status of cyanotic and acyanotic congenital heart disease patients and healthy individuals. Oxidative stress status of cyanotic and acyanotic patients does not change after cardiac surgery under cardiopulmonary bypass.
authors.affiliation: 1Department of Pediatric Cardiovascular Surgery,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital,Istanbul,Turkey.
authors.forename: Firat H
authors.initials: FH
authors.lastname: Altin
authors.affiliation: 2Department of Biochemistry,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital,Istanbul,Turkey.
authors.forename: Hayriye A
authors.initials: HA
authors.lastname: Yildirim
authors.affiliation: 3Department of Pediatric Cardiology,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital,Istanbul,Turkey.
authors.forename: Ibrahim C
authors.initials: IC
authors.lastname: Tanidir
authors.affiliation: 1Department of Pediatric Cardiovascular Surgery,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital,Istanbul,Turkey.
authors.forename: Okan
authors.initials: O
authors.lastname: Yildiz
authors.affiliation: 4Department of Anesthesiology and Reanimation,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital,Istanbul,Turkey.
authors.forename: Meliha Z
authors.initials: MZ
authors.lastname: Kahraman
authors.affiliation: 3Department of Pediatric Cardiology,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital,Istanbul,Turkey.
authors.forename: Erkut
authors.initials: E
authors.lastname: Ozturk
authors.affiliation: 4Department of Anesthesiology and Reanimation,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital,Istanbul,Turkey.
authors.forename: Sinem B
authors.initials: SB
authors.lastname: Celebi
authors.affiliation: 1Department of Pediatric Cardiovascular Surgery,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital,Istanbul,Turkey.
authors.forename: Mugisha
authors.initials: M
authors.lastname: Kyaruzi
authors.affiliation: 1Department of Pediatric Cardiovascular Surgery,Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital,Istanbul,Turkey.
authors.forename: İhsan
authors.initials: İ
authors.lastname: Bakir
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002315:Cardiopulmonary Bypass / Q000379:methods*; D016022:Case-Control Studies; D002675:Child, Preschool; D003490:Cyanosis / Q000209:etiology / Q000378:metabolism* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000097:blood* / Q000150:complications / Q000601:surgery; D006801:Humans; D008297:Male; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D011184:Postoperative Period; D011379:Prognosis; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D000975:Antioxidants; D016877:Oxidants
keywords: Antioxidant; acyanotic; cardiopulmonary bypass; cyanotic; oxidant; oxidative stress