title: Adenosine Deaminase - a Novel Diagnostic and Prognostic Biomarker for Oral Squamous Cell Carcinoma.
abstract: BACKGROUND
  The number of patients with oral cancer in India is increasing gradually (especially in younger people). Although the diagnostic modalities and therapeutic management of oral cancer are improving, the treatment outcome and prognosis of oral cancer remain poor. The absence of definite early warning symptoms for most head and neck cancers suggests that sensitive and specific biomarkers are likely to be important in screening for high-risk patients.
  
  
  OBJECTIVE
  To analyze serum adenosine deaminase (ADA) levels in oral squamous cell carcinoma (OSCC) cases who reported to our institute.
  
  
  METHODS
  A prospective study was performed on 100 histopathologically proven cases of OSCC (study group) and 100 normal healthy individuals (control group). Independent sample and one sample t-tests and one way ANOVA followed by Tuckey's POST HOC test were conducted for analysis.
  
  
  RESULTS
  Statistically significant increase in serum ADA levels was observed in OSCC cases compared to the control group. Also serum ADA level increased significantly with the histopathological grade.
  
  
  CONCLUSIONS
  Serum ADA levels in OSCC may be a useful diagnostic and prognostic biomarkers in clinical practice and our findings suggest that a large-scale study is warranted to confirm clinical utility as a prognostic and diagnostic biomarker.
authors.affiliation: Oral Pathology and Microbiology, Dentistry, YCMM and RDFs Dental College and Hospital, Ahmednagar, India E-mail : drdeepak144@gmail.com.
authors.forename: Deepak Chandrakant
authors.initials: DC
authors.lastname: Kelgandre
authors.forename: Jigna
authors.initials: J
authors.lastname: Pathak
authors.forename: Shilpa
authors.initials: S
authors.lastname: Patel
authors.forename: Pramod
authors.initials: P
authors.lastname: Ingale
authors.forename: Niharika
authors.initials: N
authors.lastname: Swain
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000201:enzymology; D016022:Case-Control Studies; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000201:enzymology; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D014408:Biomarkers, Tumor; D000243:Adenosine Deaminase