title: Long Noncoding RNA-Sox2OT Knockdown Alleviates Diabetes Mellitus-Induced Retinal Ganglion Cell (RGC) injury.
abstract: Retinal ganglion cell (RGC) injury is one of the important pathological features of diabetes-induced retinal neurodegeneration. Increasing attention has been paid to find strategies for protecting against RGC injury. Long noncoding RNAs (lncRNAs) have emerged as the key regulators of many cell functions. Here, we show that Sox2OT expression is significantly down-regulated in the retinas of STZ-induced diabetic mice and in the RGCs upon high glucose or oxidative stress. SOX2OT knockdown protects RGCs against high glucose-induced injury in vitro. Moreover, Sox2OT knockdown plays a neuroprotective role in diabetes-related retinal neurodegeneration in vivo. Sox2OT knockdown could regulate oxidative stress response in RGCs and diabetic mouse retinas. Sox2OT knockdown plays an anti-oxidative role via regulating NRF2/HO-1 signaling activity. Taken together, Sox2OT knockdown may be a therapeutic strategy for the prevention and treatment of diabetes-induced retinal neurodegeneration.
authors.affiliation: Huai' an First People's Hospital, Nanjing Medical University, Huai an, Jiangsu, China. chaopengli1981@126.com.
authors.forename: Chao-Peng
authors.initials: CP
authors.lastname: Li
authors.affiliation: Huai' an First People's Hospital, Nanjing Medical University, Huai an, Jiangsu, China.
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Wang
authors.affiliation: Huai' an First People's Hospital, Nanjing Medical University, Huai an, Jiangsu, China.
authors.forename: Wen-Qi
authors.initials: WQ
authors.lastname: Wang
authors.affiliation: Huai' an First People's Hospital, Nanjing Medical University, Huai an, Jiangsu, China.
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Song
authors.affiliation: Huai' an First People's Hospital, Nanjing Medical University, Huai an, Jiangsu, China.
authors.forename: Xiu-Ming
authors.initials: XM
authors.lastname: Liu
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D003930:Diabetic Retinopathy / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D055785:Gene Knockdown Techniques; D005947:Glucose / Q000633:toxicity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000378:metabolism* / Q000473:pathology
chemical_list: D062085:RNA, Long Noncoding; C000610979:long non-coding RNA Sox2ot, human; D005947:Glucose
keywords: Diabetic retinopathy; Long noncoding RNA; NRF2/HO-1 signaling; Retinal ganglion cell (RGC)