title: Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis.
abstract: Abnormality of glutathione peroxidase (GPx) is involved in the etiology and pathogenesis of vitiligo. However, the results were controversial. Aim. The purpose of this meta-analysis is to compare the levels of GPx between vitiligo patients and healthy controls. Methods. Relevant published articles were searched according to eligibility criteria. A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% confidence interval (CI). Results. Twenty-three studies with a total of 1076 vitiligo patients and 770 healthy controls were included. The pooled meta-analysis showed that patients with vitiligo had equivalent levels of GPx with the healthy controls (SMD = -0.47, 95% CI: -1.03 to 0.08, and p = 0.095). Further subgroup analysis showed that the GPx levels of Asian patients or segmental vitiligo patients were, respectively, lower than those of healthy controls (Asian: SMD = -0.47, 95% CI: -1.08 to 0.14, and p = 0.001; segmental: SMD = -3.59, 95% CI: -6.38 to -0.80, and p = 0.012). Furthermore, the GPx levels in serum/plasma were significantly decreased in either stable or active vitiligo patients, comparing to healthy controls (stable: SMD = -2.01, 95% CI: -3.52 to -0.49, and p = 0.009; active: SMD = -2.34, 95% CI: -4.07 to -0.61, and p = 0.008). Conclusion. This meta-analysis showed a significant association between low GPx level and vitiligo.
authors.affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Bi-Huan
authors.initials: BH
authors.lastname: Xiao
authors.affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Meihui
authors.initials: M
authors.lastname: Shi
authors.affiliation: Department of General Surgery, Shandong Qianfoshan Hospital, Jinan 250014, China.
authors.forename: Hongqiang
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Dermatology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
authors.forename: Shaoshan
authors.initials: S
authors.lastname: Cui
authors.affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Yan
authors.identifier: 0000-0002-1043-3155
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Xing-Hua
authors.initials: XH
authors.lastname: Gao
authors.affiliation: Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Hong-Duo
authors.initials: HD
authors.lastname: Chen
mesh_terms: D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D039781:PubMed; D014820:Vitiligo / Q000097:blood* / Q000503:physiopathology
chemical_list: D005979:Glutathione Peroxidase