title: [Bioinformatics in Cancer Clinical Sequencing -- An Emerging Field of Cancer Personalized Medicine].
abstract: Thus far, bioinformatics has mostly been applied in basic science research. It was initially used to analyze protein sequences in unicellular organisms, aiding discoveries in basic biology. Following the completion of human genome sequencing, it has also facilitated numerous discoveries in basic medicine. Recently, several clinical applications of bioinformatics have been reported. Most relevantly, bioinformatics has been applied to clinical sequencing - an emerging field of personalized medicine, or precision medicine. In this review, I will introduce basic techniques of bioinformatics used in clinical sequencing, avoiding excessive technical details. I will also discuss future directions for data analysis using bioinformatics in the field of personalized medicine.
authors.affiliation: Dept. of Bioinformatics, National Cancer Center.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Kato
mesh_terms: D019295:Computational Biology / Q000379:methods*; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy*; D057285:Precision Medicine; D017422:Sequence Analysis, DNA