title: Enantiodivergent Combination of Natural Product Scaffolds Enabled by Catalytic Enantioselective Cycloaddition.
abstract: An efficient strategy has been established for the enantiodivergent synthesis of natural product inspired compounds embodying both tropane and pyrrolidine natural product fragments. This strategy includes the enantioselective kinetic resolution of racemic tropanes by means of a copper(I)-catalyzed [3+2] cycloaddition and allows the preparation of two enantiopure products in a one-pot reaction in high yield and with high diastereo- and enantioselectivity by using one chiral catalyst.
authors.affiliation: Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.affiliation: Technische Universität Dortmund, Fakultät Chemie und Chemische Biologie, Anorganische Chemie, Otto-Hahn-Strasse 6, 44221, Dortmund, Germany.
authors.forename: Christopher
authors.initials: C
authors.lastname: Golz
authors.affiliation: Technische Universität Dortmund, Fakultät Chemie und Chemische Biologie, Anorganische Chemie, Otto-Hahn-Strasse 6, 44221, Dortmund, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Strohmann
authors.affiliation: Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany. andrey.antonchick@mpi-dortmund.mpg.de.|Technische Universität Dortmund, Fakultät Chemie and Chemische Biologie, Chemische Biologie, Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany. andrey.antonchick@mpi-dortmund.mpg.de.
authors.forename: Andrey P
authors.initials: AP
authors.lastname: Antonchick
authors.affiliation: Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany. herbert.waldmann@mpi-dortmund.mpg.de.|Technische Universität Dortmund, Fakultät Chemie and Chemische Biologie, Chemische Biologie, Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany. herbert.waldmann@mpi-dortmund.mpg.de.
authors.forename: Herbert
authors.initials: H
authors.lastname: Waldmann
keywords: asymmetric catalysis; cycloaddition; enantiomers; kinetic resolution; tropane