title: New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.
abstract: A new rare casbane-type diterpenoid 1 and two new cembrane diterpenoids 2, 3 were isolated from an Okinawan soft coral, Lobophytum sp., together with four known cembrane diterpenoids 4-7. Their structures were elucidated by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS) and a molecular modeling study. The new isolates showed weak anti-bacterial activity, mild cytotoxicity against HCT116 cells, and anti-inflammatory effect in LPS/IFN-γ-stimulated RAW 264.7 macrophage cells.
authors.affiliation: Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-cho, Okinawa 903-2013, Japan. prodipkroy@gmail.com.
authors.forename: Prodip K
authors.initials: PK
authors.lastname: Roy
authors.affiliation: Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-cho, Okinawa 903-2013, Japan. 79earth.rararalune@gmail.com.
authors.forename: Runa
authors.initials: R
authors.lastname: Ashimine
authors.affiliation: Department of Bioresources Engineering, Okinawa National College of Technology, 905 Henoko, Nago-shi, Okinawa 905-2192, Japan. br111436@edu.okinawa-ct.ac.jp.
authors.forename: Haruna
authors.initials: H
authors.lastname: Miyazato
authors.affiliation: Department of Bioresources Engineering, Okinawa National College of Technology, 905 Henoko, Nago-shi, Okinawa 905-2192, Japan. taira@okinawa-ct.ac.jp.
authors.forename: Junsei
authors.initials: J
authors.lastname: Taira
authors.affiliation: Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-cho, Okinawa 903-2013, Japan. kueda@sci.u-ryukyu.ac.jp.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Ueda
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D049109:Cell Proliferation / Q000187:drug effects*; D004224:Diterpenes / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D045325:HCT116 Cells; D006801:Humans; D007239:Infections / Q000188:drug therapy / Q000382:microbiology; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008070:Lipopolysaccharides / Q000633:toxicity; D051379:Mice; D015394:Molecular Structure; D000067996:RAW 264.7 Cells / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D008070:Lipopolysaccharides
keywords: HCT 116 cells; anti-inflammatory; antibacterial; casbane; cembrane; cytotoxicity