title: Clinicopathological Features of Colorectal Cancer Patients Under the Age of 50: Recent Experience and Case-Control Study of Prognosis in a Japanese Cohort.
abstract: OBJECTIVE
  The incidence of colorectal cancer (CRC) in young people is increasing, indicating an urgent need for understanding young-onset CRC. This study serves to clarify the characteristics and prognosis of young CRC patients.
  
  
  METHODS
  Using a detailed database, various clinicopathological findings including symptoms, family history and prognosis of 70 young CRC patients under 50 years who underwent surgical resection between 2005 and 2011 were compared to 786 old CRC patients over 50 years. For the comparison of prognosis, a matched 1:4 case-control study adjusting for gender, tumor location, tumor differentiation type, and Union For International Cancer Control stage was conducted.
  
  
  RESULTS
  The young group had a higher proportion of rectal cancer (51.4 vs. 36.4%, p = 0.004) and a higher positive rate for the Amsterdam criteria II (7.1 vs. 1.9%, p = 0.02) than the old group. There was no significant difference in overall survival (OS) or cancer-specific survival (CSS) between the young and old groups (5-year OS: 84.7 vs. 76.9%, p = 0.18; 5-year CSS: 84.7 vs. 82.8%, p = 0.55).
  
  
  CONCLUSIONS
  This study may add a new perspective to understanding young-onset CRC. The prognosis of young CRC patients was equivalent to that of old CRC patients.
authors.affiliation: Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Nagai
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hata
authors.forename: Kazushige
authors.initials: K
authors.lastname: Kawai
authors.forename: Koji
authors.initials: K
authors.lastname: Murono
authors.forename: Koji
authors.initials: K
authors.lastname: Yasuda
authors.forename: Kensuke
authors.initials: K
authors.lastname: Otani
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Tomomichi
authors.initials: T
authors.lastname: Kiyomatsu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nozawa
authors.forename: Hironori
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Soichiro
authors.initials: S
authors.lastname: Ishihara
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies