title: The functional activity of hypothalamic signaling systems in rats with neonatal diabetes mellitus treated with metformin.
abstract: The effect of the two-month metformin treatment (200 mg/kg/day) of rats with the neonatal model of type 2 diabetes mellitus on the functional activity of hypothalamic signaling systems was studied. It was shown that metformin treatment restored the sensitivity of hypothalamic adenylyl cyclase signaling system to agonists of the type 4 melanocortin receptor and the type 2 dopamine receptor but did not influence significantly the functions of the insulin signaling system. These data suggest new targets and mechanisms of metformin action in the CNS, which may mediate its restoring effect on energy homeostasis impaired in diabetic pathology.
authors.affiliation: Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 44, St. Petersburg, 194223, Russia.
authors.forename: K V
authors.initials: KV
authors.lastname: Derkach
authors.affiliation: Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 44, St. Petersburg, 194223, Russia.
authors.forename: I B
authors.initials: IB
authors.lastname: Sukhov
authors.affiliation: Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 44, St. Petersburg, 194223, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Kuznetsova
authors.affiliation: Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 44, St. Petersburg, 194223, Russia.
authors.forename: D M
authors.initials: DM
authors.lastname: Buzanakov
authors.affiliation: Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 44, St. Petersburg, 194223, Russia. alex_shpakov@list.ru.
authors.forename: A O
authors.initials: AO
authors.lastname: Shpakov
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D021461:Animals, Outbred Strains; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D006728:Hormones / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D008687:Metformin / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D044105:Receptor, Melanocortin, Type 4 / Q000819:agonists / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000819:agonists / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: C000607792:DRD2 protein, rat; D006728:Hormones; D007004:Hypoglycemic Agents; D007328:Insulin; D012333:RNA, Messenger; D044105:Receptor, Melanocortin, Type 4; D017448:Receptors, Dopamine D2; C000613745:melanocortin receptor type 4, rat; D008687:Metformin; D000262:Adenylyl Cyclases