title: Voxel Based Morphometry in Optical Coherence Tomography: Validation & Core Findings.
abstract: Optical coherence tomography (OCT) of the human retina is now becoming established as an important modality for the detection and tracking of various ocular diseases. Voxel based morphometry (VBM) is a long standing neuroimaging analysis technique that allows for the exploration of the regional differences in the brain. There has been limited work done in developing registration based methods for OCT, which has hampered the advancement of VBM analyses in OCT based population studies. Following on from our recent development of an OCT registration method, we explore the potential benefits of VBM analysis in cohorts of healthy controls (HCs) and multiple sclerosis (MS) patients. Specifically, we validate the stability of VBM analysis in two pools of HCs showing no significant difference between the two populations. Additionally, we also present a retrospective study of age and sex matched HCs and relapsing remitting MS patients, demonstrating results consistent with the reported literature while providing insight into the retinal changes associated with this MS subtype.
authors.affiliation: Department of Electrical and Computer Engineering, Johns Hopkins University.
authors.forename: Bhavna J
authors.initials: BJ
authors.lastname: Antony
authors.affiliation: Penn Image Computing and Science Laboratory, The University of Pennsylvania.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Electrical and Computer Engineering, Johns Hopkins University.
authors.forename: Aaron
authors.initials: A
authors.lastname: Carass
authors.affiliation: Department of Math & Statistics, Portland State University.
authors.forename: Bruno M
authors.initials: BM
authors.lastname: Jedynak
authors.affiliation: Department of Neurology, Johns Hopkins School of Medicine.
authors.forename: Omar
authors.initials: O
authors.lastname: Al-Louzi
authors.affiliation: Wilmer Eye Institute, Johns Hopkins School of Medicine.
authors.forename: Sharon D
authors.initials: SD
authors.lastname: Solomon
authors.affiliation: Department of Neurology, Johns Hopkins School of Medicine.
authors.forename: Shiv
authors.initials: S
authors.lastname: Saidha
authors.affiliation: Department of Neurology, Johns Hopkins School of Medicine.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Calabresi
authors.affiliation: Department of Electrical and Computer Engineering, Johns Hopkins University.
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Prince
keywords: RAVENS; multiple sclerosis; normalized atlas; optical coherence tomography; registration; retina; voxel-based morphometry