title: MicroRNAs regulate signaling pathways in osteogenic differentiation of mesenchymal stem cells (Review).
abstract: Osteogenesis is a complex multi-step process involving the differentiation of mesenchymal stem cells (MSCs) into osteoblast progenitor cells, preosteoblasts, osteoblasts and osteocytes, and the crosstalk between multiple cell types for the formation and remodeling of bone. The signaling regulatory networks during osteogenesis include various components, including growth factors, transcription factors, micro (mi)RNAs and effectors, a number of which form feedback loops controlling the balance of osteogenic differentiation by positive or negative regulation. miRNAs have been found to be important regulators of osteogenic signaling pathways in multiple aspects and multiple signaling pathways. The present review focusses on the progress in elucidating the role of miRNA in the osteogenesis signaling networks of MSCs as a substitute for bone implantation the the field of bone tissue engineering. In particular, the review classifies which miRNAs promote or suppress the osteogenic process, and summarizes which signaling pathway these miRNAs are involved in. Improvements in knowledge of the characteristics of miRNAs in osteogenesis provide an important step for their application in translational investigations of bone tissue engineering and bone disease.
authors.affiliation: Hunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Peng
authors.affiliation: Hunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China.
authors.forename: Dan
authors.initials: D
authors.lastname: Gao
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha, Hunan 410083, P.R. China.
authors.forename: Chengde
authors.initials: C
authors.lastname: Gao
authors.affiliation: Hunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China.
authors.forename: Pingpin
authors.initials: P
authors.lastname: Wei
authors.affiliation: Hunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China.
authors.forename: Man
authors.initials: M
authors.lastname: Niu
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha, Hunan 410083, P.R. China.
authors.forename: Cijun
authors.initials: C
authors.lastname: Shuai
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics*; D010012:Osteogenesis / Q000235:genetics; D034622:RNA Interference; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs