title: Sporadic Cerebral Amyloid Angiopathy: Pathophysiology, Neuroimaging Features, and Clinical Implications.
abstract: Sporadic cerebral amyloid angiopathy is a small vessel disorder defined pathologically by progressive amyloid deposition in the walls of cortical and leptomeningeal vessels resulting from disruption of a complex balance between production, circulation, and clearance of amyloid-β peptide (Aβ) in the brain. Cerebral amyloid angiopathy is a major cause of lobar symptomatic intracerebral hemorrhage, transient focal neurologic episodes, and a key contributor to vascular cognitive impairment. The mechanisms and consequences of amyloid-β deposition at the pathological level and its neuroimaging manifestations, clinical consequences, and implications for patient care are addressed in this review.
authors.affiliation: Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, Massachusetts.
authors.forename: Gregoire
authors.initials: G
authors.lastname: Boulouis
authors.affiliation: Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, Massachusetts.
authors.forename: Andreas
authors.initials: A
authors.lastname: Charidimou
authors.affiliation: Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, Massachusetts.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Greenberg
mesh_terms: D016229:Amyloid beta-Peptides; D001921:Brain; D016657:Cerebral Amyloid Angiopathy / Q000000981:diagnostic imaging / Q000628:therapy; D002543:Cerebral Hemorrhage; D006801:Humans; D059906:Neuroimaging
chemical_list: D016229:Amyloid beta-Peptides