title: Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks.
abstract: Analysis of intravascular optical coherence tomography (IVOCT) data has potential for real-time in vivo plaque classification. We developed a processing pipeline on a three-dimensional local region of support for estimation of optical properties of atherosclerotic plaques from coronary artery, IVOCT pullbacks. Using realistic coronary artery disease phantoms, we determined insignificant differences in mean and standard deviation estimates between our pullback analyses and more conventional processing of stationary acquisitions with frame averaging. There was no effect of tissue depth or oblique imaging on pullback parameter estimates. The method's performance was assessed in comparison with observer-defined standards using clinical pullback data. Values (calcium [Formula: see text], lipid [Formula: see text], and fibrous [Formula: see text]) were consistent with previous measurements obtained by other means. Using optical parameters ([Formula: see text], [Formula: see text], [Formula: see text]), we achieved feature space separation of plaque types and classification accuracy of [Formula: see text]. Despite the rapid [Formula: see text] motion and varying incidence angle in pullbacks, the proposed computational pipeline appears to work as well as a more standard "stationary" approach.
authors.affiliation: Case Western Reserve University , Department of Electrical Engineering and Computer Science, Cleveland, Ohio 44106, United States.
authors.forename: Ronny
authors.initials: R
authors.lastname: Shalev
authors.affiliation: Case Western Reserve University , Department of Biomedical Engineering, Cleveland, Ohio 44106, United States.
authors.forename: Madhusudhana
authors.initials: M
authors.lastname: Gargesha
authors.affiliation: Case Western Reserve University , Department of Biomedical Engineering, Cleveland, Ohio 44106, United States.
authors.forename: David
authors.initials: D
authors.lastname: Prabhu
authors.affiliation: University Hospitals Case Medical Center , Harrington Heart and Vascular Institute, Imaging Core Laboratory, Cleveland, Ohio 44106, United States.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Case Western Reserve University , Department of Biomedical Engineering, Cleveland, Ohio 44106, United States.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Rollins
authors.affiliation: National Research Council , 75, de Mortagne, Boucherville, Quebec J4B 6Y4, Canada.
authors.forename: Guy
authors.initials: G
authors.lastname: Lamouche
authors.affiliation: National Research Council , 75, de Mortagne, Boucherville, Quebec J4B 6Y4, Canada.
authors.forename: Charles-Etienne
authors.initials: CE
authors.lastname: Bisaillon
authors.affiliation: University Hospitals Case Medical Center , Harrington Heart and Vascular Institute, Imaging Core Laboratory, Cleveland, Ohio 44106, United States.
authors.forename: Hiram G
authors.initials: HG
authors.lastname: Bezerra
authors.affiliation: Case Western Reserve University , Department of Electrical Engineering and Computer Science, Cleveland, Ohio 44106, United States.
authors.forename: Soumya
authors.initials: S
authors.lastname: Ray
authors.affiliation: Case Western Reserve University, Department of Biomedical Engineering, Cleveland, Ohio 44106, United States; Case Western Reserve University, Department of Radiology, Cleveland, Ohio 44106, United States.
authors.forename: David L
authors.initials: DL
authors.lastname: Wilson
keywords: optical coherence tomography; parameters