title: Powering up the molecular therapy of RNA interference by novel nanoparticles.
abstract: RNA interference technology has been widely applied in biomedical therapy in recent years. A type of small RNA molecule - siRNA could regulate the expression of disease related genes by breaking down the integrity of mRNA with high specificity. However, the low efficiency of siRNA delivery to its target seriously hampered the RNAi therapy. Compared with viral-based delivery systems, non-viral-based nanoparticles are more suitable for disease treatment due to reduced cellular toxicity, higher loading capacity, and better biocompatibility. This review article highlights several nanoparticle-based siRNA delivery systems, including liposomes, cationic solid lipid nanoparticles, reconstituted high density lipoprotein, polymeric nanoparticles, cationic cell penetrating peptides, and inorganic nanoparticles. The molecular mechanism of gene silencing, clinical examples, and the limitations of current technology related to nanomaterial sciences, are also discussed.
authors.affiliation: Institute of Food Safety and Nutrition, Jinan University, 601 West, Huangpu Road, Guangzhou, 510632, China. ttzhang89@hotmail.com and Department of Food Science and Technology, South China University of Technology, Guangzhou, 510640, China.
authors.forename: Wenzhen
authors.initials: W
authors.lastname: Liao
authors.affiliation: IHRC, Inc., 2 Ravinia Drive, Suite 1750, Atlanta, GA 30346, USA.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: Institute of Food Safety and Nutrition, Jinan University, 601 West, Huangpu Road, Guangzhou, 510632, China. ttzhang89@hotmail.com.
authors.forename: Tiantian
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Natural Sciences, Clayton State University, 2000 Clayton State Boulevard, Morrow, GA 30260, USA.
authors.forename: Micheal
authors.initials: M
authors.lastname: Kirberger
authors.affiliation: Department of Food and Bioproduct Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK S7N 5A8, Canada.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina 28081, USA.
authors.forename: Pei
authors.initials: P
authors.lastname: Wang
authors.affiliation: Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Food Science and Engineering, Jinan University, 601 West, Huangpu Road, Guangzhou, 510632, China. twyong@jnu.edu.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
mesh_terms: D016503:Drug Delivery Systems / Q000592:standards / Q000639:trends; D006801:Humans; D008081:Liposomes; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D008081:Liposomes; D034741:RNA, Small Interfering