title: [Study of cardiovascular morbidity in nurses exposed to cytostatic drugs: Multivaried approach analysis].
abstract: OBJECTIVE
  To investigate the relationship between cardiovascular morbidity and exposure to cytostatic drugs.
  
  
  METHODS
  A descriptive analytical study was conducted with 74 nurses exposed to cytostatic drugs in oncology and 215 unexposed. A medical questionnaire was applied. Exposure to cytostatic drugs was estimated by the exposure time and the index of cytostatic contact (ICC). The statistical tests used are: relative risk, odds ratio, multivariate analysis: descriptive (ACM) and predictive (AIC system).
  
  
  RESULTS
  It is a young population; the average age is 42±9.9years with a female predominance (81%). The average length was 18.4±11.11years. The average of the ICC ranged from 0.60 to 12.6 with a highly significant difference. For morbidity, there was no difference for most cardiovascular disease (RR, 1.03; 95% CI [0.59; 1.82]) outside of hypertension and venous thrombosis. ACM objectified separation between the terms and the comments of the two groups for HTA. The interpretation of results at alpha=0.05 showed an association with cardiovascular disease. The study of the association between cardiovascular morbidity and exposure to cytostatic objectified association with seniority and the ICC with a statistically significant difference (P=0.01).
  
  
  CONCLUSIONS
  Multivariate analysis helped to eliminate confounding factors and retain the ICC and length of exposure to cytostatic in the onset of cardiovascular morbidity.
authors.affiliation: Service médecine du travail, faculté de médecine, université Badji Mokhtar d'Annaba, 23000 Annaba, Algérie. Electronic address: nadia.tighabouaziz@gmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Tigha Bouaziz
authors.affiliation: Service médecine du travail, faculté de médecine, université Badji Mokhtar d'Annaba, 23000 Annaba, Algérie.
authors.forename: D
authors.initials: D
authors.lastname: Tourab
authors.affiliation: Service médecine du travail, faculté de médecine, université Badji Mokhtar d'Annaba, 23000 Annaba, Algérie.
authors.forename: A M
authors.initials: AM
authors.lastname: Nezzal
mesh_terms: D000328:Adult; D000462:Algeria / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000451:nursing*; D054697:Cytostatic Agents / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008495:Medical Oncology; D008875:Middle Aged; D009726:Nurses / Q000706:statistics & numerical data; D016273:Occupational Exposure / Q000009:adverse effects*; D012307:Risk Factors; D013997:Time Factors
chemical_list: D054697:Cytostatic Agents
keywords: ACM; AIC; Analyse des correspondances multiples; Cardiotoxicity; Cardiotoxicité; Cytostatics; Cytostatiques; Infirmier; Nurse; Système AIC