title: Use of antipsychotics and risk of myocardial infarction: a systematic review and meta-analysis.
abstract: There is emerging concern that antipsychotics may be associated with an increased risk of myocardial infarction (MI). A previous review identified five observational studies that did not provide an accurate estimate of the association between antipsychotic drug use and MI risk. More recent studies have produced variable results.
  
  
  
  We performed a systematic review and meta-analysis of observational studies to determine whether antipsychotic use affects the risk for MI. Our analysis included all observational studies that compared MI incidence among patients receiving antipsychotics vs. no treatment.
  
  
  
  Nine observational studies were included in the analysis. The odds for developing MI were 1.88-fold higher (odds ratio (OR) 1.88, 95% confidence interval (CI) 1.39, 2.54) in antipsychotic users compared with individuals who had not taken antipsychotics. Subgroup analyses found an OR of 2.48 (95% CI 1.66, 3.69) among patients with schizophrenia and an OR of 2.64 (95% CI 2.48, 2.81) among short term (<30 days) antipsychotic users.
  
  
  
  The findings of this meta-analysis support an increased risk of MI in antipsychotic drug users. The present systematic review expands previous knowledge by demonstrating an increased and more pronounced risk in short term users.
authors.affiliation: Department of Psychiatry, Hangzhou Seventh People's Hospital, Hangzhou, 310013, PR China.
authors.forename: Zheng-He
authors.initials: ZH
authors.lastname: Yu
authors.affiliation: Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
authors.forename: Hai-Yin
authors.initials: HY
authors.lastname: Jiang
authors.affiliation: Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shao
authors.affiliation: Mental Health Institute, the Second Xiangya Hospital, Central South University, Changsha, 410011.|Department of Child Psychiatry, Hangzhou Seventh People's Hospital, Hangzhou, 310013, PR China.
authors.forename: Yuan-Yue
authors.initials: YY
authors.lastname: Zhou
authors.affiliation: Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Shi
authors.affiliation: Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Ruan
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D006801:Humans; D009203:Myocardial Infarction / Q000139:chemically induced*
chemical_list: D014150:Antipsychotic Agents
keywords: antipsychotic agents; coronary disease; myocardial infarction