title: Susceptibility to human cancer: From the perspective of a pathologist.
abstract: The etiologies of human cancer can only be discerned when the genetic clustering of cancer occurs within a family or when cancer occurs endemically in a particular environment. The possible approaches to solving the nature/nurture problem, especially for human carcinogenesis, posit a fascinating challenge for pathologists. This perspective review presents some examples of how clues to human cancer etiologies and/or susceptibilities reside in the realm of pathology practice. These examples using various omics techniques including adductomics, which I would like to highlight in this article, show that the currently available concepts and methods in human pathology can open a path toward the brave new world of a post-genomic era of medicine for young pathologists, whether their original intention was toward the pursuit of diagnostic or investigative knowledge.
authors.affiliation: Department of Tumor Pathology, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sugimura
mesh_terms: D020022:Genetic Predisposition to Disease; D023281:Genomics; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D010336:Pathology / Q000639:trends*
keywords: adductome; adductomics; cancer susceptibility; exposome; gene-environmental interaction; genetic polymorphism; molecular epidemiology