title: Muscle regeneration after sepsis.
abstract: Severe critical illness is often complicated by intensive care unit-acquired weakness (ICU-AW), which is associated with increased ICU and post-ICU mortality, delayed weaning from mechanical ventilation and long-term functional disability. Several mechanisms have been implicated in the pathophysiology of ICU-AW, but muscle regeneration has not been investigated to any extent in this context, even though its involvement is suggested by the protracted functional consequences of ICU-AW. Recent data suggest that muscle regeneration could be impaired after sepsis, and that mesenchymal stem cell treatment could improve the post-injury muscle recovery.
authors.affiliation: Human Histopathology and Animal Models Unit, Infection and Epidemiology Department, Institut Pasteur, 75724 cedex15, Paris, France. adrien.bougle@aphp.fr.|Anesthesiology and Intensive Care, Institut de Cardiologie, Hôpitaux Universitaires La Pitié-Salpêtrière, Paris, 75013, France. adrien.bougle@aphp.fr.
authors.forename: Adrien
authors.initials: A
authors.lastname: Bouglé
authors.affiliation: Human Histopathology and Animal Models Unit, Infection and Epidemiology Department, Institut Pasteur, 75724 cedex15, Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Rocheteau
authors.affiliation: Human Histopathology and Animal Models Unit, Infection and Epidemiology Department, Institut Pasteur, 75724 cedex15, Paris, France.|Intensive Care, Hôpital Raymond Poincaré, Garches, 92380, France.|Versailles Saint Quentin University, Versailles, 78000, France.|TRIGGERSEP, F-CRIN Network, Versailles, 78000, France.
authors.forename: Tarek
authors.initials: T
authors.lastname: Sharshar
authors.affiliation: Human Histopathology and Animal Models Unit, Infection and Epidemiology Department, Institut Pasteur, 75724 cedex15, Paris, France.|TRIGGERSEP, F-CRIN Network, Versailles, 78000, France.|Neuropathology Laboratory, Centre Hospitalier Sainte Anne, Paris, 75014, France.|Paris Descartes University, Sorbonne Paris Cité, Paris, 75006, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Chrétien
mesh_terms: D016638:Critical Illness / Q000534:rehabilitation; D006801:Humans; D007362:Intensive Care Units / Q000458:organization & administration; D007902:Length of Stay; D018908:Muscle Weakness / Q000209:etiology; D009132:Muscles / Q000503:physiopathology*; D012038:Regeneration / Q000502:physiology*; D018805:Sepsis / Q000150:complications / Q000503:physiopathology*