title: Retrospective clinicopathological study of 129 cancerous and 18 precancerous lesions of the eyelids in North-Western Greece.
abstract: This study aimed to present precancerous and cancerous epithelial eyelid lesions, their histopathological features, and possible correlations with clinical parameters. The retrospective study included 147 formalin-fixed, paraffin-embedded samples. We studied precancerous and cancerous epithelial eyelid lesions. Preneoplastic tumors were represented by 12 actinic keratoses and 6 in situ squamous cell carcinomas (Bowen disease) and skin epithelial tumors by 119 basal and 10 squamous cell carcinomas. We recorded the clinicomorphological and histopathological features of the specimens and investigated possible correlations. In our study, the vast majority of pre-malignant and malignant tumors occurred in advanced age (mean age of occurrence: 70.18 years). The data analysis showed that inflammation in patients with basal cell carcinoma (BCC) positively correlated with advanced age (p < 0.01), tumor diameter (p < 0.05), and the appearance of ulceration (p < 0.001). A prevalence of female sex was noted in the BCC group. We also found that inflammation with or without the presence of ulceration was more commonly seen in carcinomatous lesions than in preneoplastic lesions (p < 0.05). Inflammation occurrence is present in high proportions in the tumors studied and correlates with some clinicopathological parameters such as the age of patients, the mean tumor diameter, and the presence of ulceration. The comparison between premalignant and malignant conditions showed that inflammation probability increases as we move toward the more aggressive tumor phenotypes.
authors.affiliation: Department of Pathology, University of Ioannina Medical School, 45110, Ioannina, Greece. ktzoutzos@yahoo.gr.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Tzoutzos
authors.affiliation: Department of Pathology, University of Ioannina Medical School, 45110, Ioannina, Greece.
authors.forename: Anna
authors.initials: A
authors.lastname: Batistatou
authors.affiliation: Department of Ophthalmology, University of Ioannina, Ioannina, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Kitsos
authors.affiliation: Department of Biological Applications and Technologies, University of Ioannina, Ioannina, Greece.
authors.forename: Roman
authors.initials: R
authors.lastname: Liasko
authors.affiliation: Department of Pathology, University of Ioannina Medical School, 45110, Ioannina, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Stefanou
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000453:epidemiology / Q000473:pathology*; D005142:Eyelid Neoplasms / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D055623:Keratosis, Actinic / Q000453:epidemiology / Q000473:pathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000453:epidemiology / Q000473:pathology*; D012189:Retrospective Studies; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000453:epidemiology / Q000473:pathology*
keywords: Actinic keratosis; Basal cell carcinoma; Eyelid; Histopathology; Squamous cell carcinoma