title: Regulation of Genome Architecture and Function by Polycomb Proteins.
abstract: Polycomb group (PcG) proteins dynamically define cellular identities through the epigenetic repression of key developmental regulatory genes. PcG proteins are recruited to specific regulatory elements to modify the chromatin surrounding them. In addition, they regulate the organization of their target genes in the 3D space of the nucleus, and this regulatory function of the 3D genome architecture is involved in cell differentiation and the maintenance of cellular memory. In this review we discuss recent advances in our understanding of how PcG proteins are recruited to chromatin to induce local and global changes in chromosome conformation and regulate their target genes.
authors.affiliation: Institute of Human Genetics, CNRS UPR1142 and University of Montpellier, 141 Rue de la Cardonille, 34396, Montpellier Cedex 5, France.
authors.forename: Marianne
authors.initials: M
authors.lastname: Entrevan
authors.affiliation: Institute of Human Genetics, CNRS UPR1142 and University of Montpellier, 141 Rue de la Cardonille, 34396, Montpellier Cedex 5, France. Electronic address: Bernd.Schuttengruber@igh.cnrs.fr.
authors.forename: Bernd
authors.initials: B
authors.lastname: Schuettengruber
authors.affiliation: Institute of Human Genetics, CNRS UPR1142 and University of Montpellier, 141 Rue de la Cardonille, 34396, Montpellier Cedex 5, France. Electronic address: Giacomo.Cavalli@igh.cnrs.fr.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Cavalli
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D044127:Epigenesis, Genetic; D016678:Genome; D006801:Humans; D008954:Models, Biological; D063146:Polycomb-Group Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D002843:Chromatin; D063146:Polycomb-Group Proteins
keywords: Polycomb group; chromatin organization; chromosome architecture; epigenetics; gene regulation