title: Adipokines and Insulin Resistance in Young Adult Survivors of Childhood Cancer.
abstract: We examined the association between adipokines (leptin, adiponectin, and resistin), radiotherapy, measurement of body fat, and insulin resistance among young adult survivors of childhood cancer (CCS). Materials and Methods. Seventy-six survivors were included (mean age 24.1 ± 3.5 years). Insulin resistance (IR) was calculated using the homeostasis model assessment (HOMA-IR). The serum levels of adipokines were assayed by immunoassays. Fat mass was evaluated by DXA. Results. Mean adiponectin level and mean body FAT were higher in the examined females than in males (10009 ± 6367 ng/mL versus 6433 ± 4136 ng/mL, p < 0.01; 35.98 ± 9.61% versus 22.7 ± 7.46%, p < 0.001). Among CCS, one of 75 patients met the criteria of insulin resistance, and in 14 patients there was impaired fasting glucose. The multiple regression model for females showed that leptin/adiponectin ratio (LA ratio) significantly affected HOMA-IR (increase of 0.024 per each unit of LA ratio; p < 0.05). Radiotherapy had no effect on serum adipokines and IR. Conclusion. The observed results support the hypothesis that adiponectin might be associated with insulin resistance and it can not be ruled out that changes in the mean level of adiponectin per FAT mass or leptin/adiponectin ratio may precede the occurrence of insulin resistance in the future.
authors.affiliation: Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, Poland.
authors.forename: Eryk
authors.initials: E
authors.lastname: Latoch
authors.affiliation: Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Muszynska-Roslan
authors.affiliation: Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Panas
authors.affiliation: Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Panasiuk
authors.affiliation: Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Sawicka-Zukowska
authors.affiliation: Department of Pediatric Laboratory Diagnostics, Medical University of Bialystok, 15-274 Bialystok, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Zelazowska-Rutkowska
authors.affiliation: Student's Scientific Society by the Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Zabrocka
authors.affiliation: Department of Pediatric Oncology and Hematology, Medical University of Bialystok, 15-274 Bialystok, Poland.
authors.forename: Maryna
authors.initials: M
authors.lastname: Krawczuk-Rybak