title: The Clinical Efficacy of Autologous Platelet-Rich Plasma Combined with Ultra-Pulsed Fractional CO2Laser Therapy for Facial Rejuvenation.
abstract: Ultra-pulsed fractional CO2laser is an efficient, precise, and safe therapeutic intervention for skin refreshing, although accompanied with prolonged edema and erythema. In recent years, autologous platelet-rich plasma (PRP) has been proven to promote wound and soft tissue healing and collagen regeneration. To investigate whether the combination of PRP and ultra-pulsed fractional CO2laser had a synergistic effect on therapy for facial rejuvenation. Totally, 13 facial aging females were treated with ultra-pulsed fractional CO2laser. One side of the face was randomly selected as experimental group and injected with PRP, the other side acted as the control group and was injected with physiological saline at the same dose. Comprehensive assessment of clinical efficacy was performed by satisfaction scores, dermatologists' double-blind evaluation and the VISIA skin analysis system. After treatment for 3 months, subjective scores of facial wrinkles, skin texture, and skin elasticity were higher than that in the control group. Similarly, improvement of skin wrinkles, texture, and tightness in the experimental group was better compared with the control group. Additionally, the total duration of erythema, edema, and crusting was decreased, in the experimental group compared with the control group. PRP combined with ultra-pulsed fractional CO2laser had a synergistic effect on facial rejuvenation, shortening duration of side effects, and promoting better therapeutic effect.
authors.affiliation: Department of Plastic Surgery, General Hospital of Shenyang Military Command , Shenyang, China .
authors.forename: Qiang
authors.initials: Q
authors.lastname: Hui
authors.affiliation: Department of Plastic Surgery, General Hospital of Shenyang Military Command , Shenyang, China .
authors.forename: Peng
authors.initials: P
authors.lastname: Chang
authors.affiliation: Department of Plastic Surgery, General Hospital of Shenyang Military Command , Shenyang, China .
authors.forename: Bingyu
authors.initials: B
authors.lastname: Guo
authors.affiliation: Department of Plastic Surgery, General Hospital of Shenyang Military Command , Shenyang, China .
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Plastic Surgery, General Hospital of Shenyang Military Command , Shenyang, China .
authors.forename: Kai
authors.initials: K
authors.lastname: Tao
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005145:Face / Q000528:radiation effects*; D005260:Female; D006801:Humans; D054020:Lasers, Gas / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D053657:Platelet-Rich Plasma / Q000378:metabolism*; D012060:Rejuvenation; D015595:Skin Aging / Q000528:radiation effects; D014182:Transplantation, Autologous; D016896:Treatment Outcome
keywords: adverse events; combination therapy; recovery time; synergistic effect