title: A new furanocoumarin from the fruits of Scaevola taccada and antifungal activity against Pythium insidiosum.
abstract: A new coumarin, scataccanol (1) and 10 known compounds were isolated from the fruits of Scaevola taccada (Gaertn.) Roxb. All compounds were evaluated for antifungal activity against Pythium insidiosum. Compounds 5 and 7 showed strong antifungal activity with minimum inhibitory concentration values of 5 and 10 μg/mL, respectively. Structural determination of all compounds was accomplished by 1D and 2D-NMR, IR and MS.
authors.affiliation: a Faculty of Science, Natural Products Research Unit, Department of Chemistry, Center of Excellence for Innovation in Chemistry , Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Jittra
authors.initials: J
authors.lastname: Suthiwong
authors.affiliation: b Faculty of Allied Health Science, Cellular and Molecular Immunology Research Unit (CMIRU), Department of Medical Technology , Naresuan University , Phitsanulok , Thailand.
authors.forename: Yordhathai
authors.initials: Y
authors.lastname: Thongsri
authors.affiliation: a Faculty of Science, Natural Products Research Unit, Department of Chemistry, Center of Excellence for Innovation in Chemistry , Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Chavi
authors.initials: C
authors.lastname: Yenjai
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D011564:Furocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011775:Pythium / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D011564:Furocoumarins
keywords: Pythium insidiosum; Scaevola taccada; antifungal; furanocoumarin; iridoid