title: Original Research: Different imiquimod creams resulting in differential effects for imiquimod-induced psoriatic mouse models.
abstract: Imiquimod (IMQ)-induced mouse psoriatic model is one of the useful models displaying most of psoriatic features. To compare the modeling efficacy of different IMQ creams, we induced the psoriatic models by topically applying two different brands of IMQ 5% creams to the shaved Balb/c mice skin and assessed the results. Balb/c female mice (n = 24) 8-12 weeks of age were randomly divided into experimental groups A (Likejie), B (Aldara), and control group C (Vaseline); Likejie, Aldara, or Vaseline was topically applied to the back skin for mice in groups A, B, and C, respectively, for six consecutive days. The total psoriasis area and severity index scores of groups A, B, and C were 3.25 ± 1.56, 9.81 ± 0.84, and 0, respectively; the Baker's scores were 2.93 ± 1.07, 6.47 ± 1.50, and 0, respectively; and the epidermis thickness was 49.79 ± 14.16, 85.62 ± 17.55, and 20.04 ± 3.68 µm, respectively. The differences between the three groups in dual were statistically significant (P < 0.005 for the groups in dual). Aldara group showed more characteristic alterations of psoriasiform lesions than that of Likejie both macroscopically and histopathologically. The results suggested that different brands of IMQ creams may result in differential efficacy when performing the IMQ-induced psoriasis mouse models.
authors.affiliation: Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510700, China luodq@mail.sysu.edu.cn.
authors.forename: Di-Qing
authors.initials: DQ
authors.lastname: Luo
authors.affiliation: Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510700, China.
authors.forename: Hui-Hui
authors.initials: HH
authors.lastname: Wu
authors.affiliation: Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510700, China.
authors.forename: Yu-Kun
authors.initials: YK
authors.lastname: Zhao
authors.affiliation: Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510700, China.
authors.forename: Juan-Hua
authors.initials: JH
authors.lastname: Liu
authors.affiliation: Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510700, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
mesh_terms: D000279:Administration, Cutaneous; D000634:Aminoquinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D000077271:Imiquimod; D051379:Mice; D008807:Mice, Inbred BALB C; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000187:drug effects / Q000473:pathology; D063465:Skin Cream; D016896:Treatment Outcome
chemical_list: D000634:Aminoquinolines; D003879:Dermatologic Agents; D000077271:Imiquimod
keywords: Baker’s score; Psoriasis; imiquimod; mouse model; psoriasis area and severity index