title: Haemophilia A and chronic hepatopathy caused by extrahepatic biliary atresia: two congenital diseases cured by orthotopic liver transplantation.
abstract: Since the publication of the first successful liver transplantation in a patient with severe haemophilia A by Lewis et al. in 1985, different authors have reported clinical cure of haemophilia A by orthotopic liver transplantation. In the published cases liver transplantation was performed due to end-stage chronic liver disease secondary to factor replacement therapy for haemophilia A or haemophilia B. Congenital biliary atresia is the most common cause of obstructive jaundice in the neonatal period and the most common indication for liver transplantation in childhood. In this article we report the first successful orthotopic liver transplantation performed in Spain, carried out in the youngest patient thus far described, a 5-year-old boy with haemophilia A and chronic liver disease secondary to congenital biliary atresia.
authors.affiliation: Haemophilia Unit, Haematology and Haemotherapy Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain,†Children's Hepatology Unit, Paediatric Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain,Paediatric Surgery Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Jiménez-Yuste
authors.affiliation: Haemophilia Unit, Haematology and Haemotherapy Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain,†Children's Hepatology Unit, Paediatric Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain,Paediatric Surgery Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Canales
authors.affiliation: Haemophilia Unit, Haematology and Haemotherapy Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain,†Children's Hepatology Unit, Paediatric Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain,Paediatric Surgery Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Jara
authors.affiliation: Haemophilia Unit, Haematology and Haemotherapy Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain,†Children's Hepatology Unit, Paediatric Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain,Paediatric Surgery Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: GÀmez
authors.affiliation: Haemophilia Unit, Haematology and Haemotherapy Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain,†Children's Hepatology Unit, Paediatric Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain,Paediatric Surgery Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Pinilla
authors.affiliation: Haemophilia Unit, Haematology and Haemotherapy Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain,†Children's Hepatology Unit, Paediatric Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain,Paediatric Surgery Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: HernÀndez-Navarro
authors.affiliation: Haemophilia Unit, Haematology and Haemotherapy Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain,†Children's Hepatology Unit, Paediatric Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain,Paediatric Surgery Department, 'La Paz' Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: MagallÓn
keywords: chronic liver disease; congenital biliary atresia; haemophilia; orthotopic liver transplantation