title: Molecular medicine - To be or not to be.
abstract: Molecular medicine is founded on the synergy between Chemistry, Physics, Biology and Medicine, with the ambitious goal of tackling diseases from a molecular perspective. This Review aims at retracing a personal outlook of the birth and development of molecular medicine, as well as at highlighting some of the most urgent challenges linked to aging and represented by incurable neurodegenerative diseases caused by protein misfolding. Furthermore, we emphasize the emerging role of the retromer dysfunctions and improper protein sorting in Alzheimer's disease and other important neurological disordered.
authors.affiliation: Istituto Pasteur - Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, 00185 Rome, Italy. Electronic address: maurizio.brunori@uniroma1.it.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Brunori
authors.affiliation: Istituto Pasteur - Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, 00185 Rome, Italy. Electronic address: stefano.gianni@uniroma1.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Gianni
mesh_terms: D000375:Aging / Q000473:pathology*; D006801:Humans; D062346:Molecular Medicine / Q000379:methods / Q000639:trends*; D019636:Neurodegenerative Diseases / Q000209:etiology*; D017510:Protein Folding / Q000187:drug effects; D021381:Protein Transport; D033921:Vesicular Transport Proteins / Q000378:metabolism
chemical_list: D033921:Vesicular Transport Proteins
keywords: Alzheimer's disease; Drug design; Hemoglobin; Prions; Protein misfolding diseases; Protein structure; Retromer