title: [Digital modeling for the individual mandibular 3D mesh scaffold based on 3D printing technology].
abstract: OBJECTIVE
  To investigate an ideal modeling method of designing 3D mesh scaffold substitutes based on tissue engineering to restore mandibular bone defects. By analyzing the theoretical model from titanium scaffolds fabricated by 3D printing, the feasibility and effectiveness of the proposed methodology were verified.
  
  
  METHODS
  Based on the CT scanned data of a subject, the Mimics 15.0 and Geomagic studio 12.0 reverse engineering software were adopted to generate surface model of mandibular bone and the defect area was separated from the 3D model of bone. Then prosthesis was designed via mirror algorithm, in which outer shape was used as the external shape of scaffold. Unigraphics software NX 8.5 was applied on Boolean calculation of subtraction between prosthesis and regular microstructure structure and ANSYS 14.0 software was used to design the inner construction of 3D mesh scaffolds. The topological structure and the geometrical parameters of 3D mesh titanium scaffolds were adjusted according to the aim of optimized structure and maximal strength with minimal weight. The 3D mesh scaffolds solid model through two kinds of computer-aided methods was input into 3D printing equipment to fabricate titanium scaffolds.
  
  
  RESULTS
  Individual scaffolds were designed successfully by two modeling methods. The finite element optimization made 10% decrease of the stress peak and volume decrease of 43%, and the porosity increased to 76.32%. This modeling method was validated by 3D printing titanium scaffold to be feasible and effective.
  
  
  CONCLUSIONS
  3D printing technology combined with finite element topology optimization to obtain the ideal mandibular 3D mesh scaffold is feasible and effective.
authors.affiliation: Department of Oral and Maxillofacial Surgery, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Rongzeng
authors.initials: R
authors.lastname: Yan
authors.affiliation: Department of Mechanics and Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Danmei
authors.initials: D
authors.lastname: Luo
authors.affiliation: School of Energy and Power Engineering, Beihang University, Beijing 100191, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Oral and Maxillofacial Surgery, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Runxin
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Mechanics and Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Qiguo
authors.initials: Q
authors.lastname: Rong
authors.affiliation: Department of Oral and Maxillofacial Surgery, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Min
authors.initials: M
authors.lastname: Hu
mesh_terms: D005240:Feasibility Studies; D006801:Humans; D008334:Mandible / Q000033:anatomy & histology*; D016062:Porosity; D066330:Printing, Three-Dimensional; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014025:Titanium
chemical_list: D014025:Titanium