title: Chiral Ferrocenyl P,N-Ligands for Palladium-Catalyzed Asymmetric Formal [3 + 2] Cycloaddition of Propargylic Esters with β-Ketoesters: Access to Functionalized Chiral 2,3-Dihydrofurans.
abstract: A highly enantioselective palladium-catalyzed [3 + 2] cycloaddition of propargylic esters with β-ketoesters has been realized by employing a newly developed chiral ferrocene/benzimidazole-based P,N-ligand. This protocol features a good tolerance of functional groups in both propargylic esters and β-ketoesters, thereby delivering a variety of highly functionalized chiral 2,3-dihydrofurans bearing an exocyclic double bond at the 3-position in good yields and with high enantioselectivities (up to 98% ee).
authors.affiliation: Biotechnology Research Center, Hunan Academy of Agricultural Sciences , Changsha 410125, China.|Collaborative Innovation Center for Field Weeds Control, Hunan Loudi 417000, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
authors.forename: Fu-Lin
authors.initials: FL
authors.lastname: Zhu
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
authors.forename: Zhen-Ting
authors.initials: ZT
authors.lastname: Liu
authors.affiliation: Biotechnology Research Center, Hunan Academy of Agricultural Sciences , Changsha 410125, China.|Collaborative Innovation Center for Field Weeds Control, Hunan Loudi 417000, China.
authors.forename: Xiao-Mao
authors.initials: XM
authors.lastname: Zhou
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
authors.forename: Xiang-Ping
authors.initials: XP
authors.lastname: Hu