title: Bowel Perforation Associated With Infliximab Use in a Pediatrics Patient.
abstract: Crohn's disease (CD) is an idiopathic inflammatory disease of the gastrointestinal tract and typically causes inflammation with granuloma formation. Biologic agents like infliximab (IFX) that target tumor necrosis factor alpha (TNF-α), have emerged as important medications for treating refractory CD. With increasing use, there also are reports of rare but potentially fatal complications associated with exposure to TNF-α, such as bowel perforation. We present a case report of spontaneous bowel perforation in a child with Crohn's while on IFX therapy, and a review of the current literature. The purpose of this report is to alert physicians to this rare association, especially in pediatric patients with intestinal strictures.
authors.forename: Aditya
authors.initials: A
authors.lastname: Joshi
authors.forename: Raza
authors.initials: R
authors.lastname: Bajwa
authors.forename: Nandita
authors.initials: N
authors.lastname: Bhattacharjee
authors.forename: Rajasekhar
authors.initials: R
authors.lastname: Bodicharla
mesh_terms: D002648:Child; D003424:Crohn Disease / Q000188:drug therapy*; D005765:Gastrointestinal Agents / Q000009:adverse effects*; D006801:Humans; D000069285:Infliximab / Q000009:adverse effects*; D007416:Intestinal Perforation / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D008297:Male
chemical_list: D005765:Gastrointestinal Agents; D000069285:Infliximab