title: Long non-coding RNAs as novel therapeutic targets in cancer.
abstract: Thanks to impressive technology advancements, pervasive expression of non-coding RNAs (ncRNAs) has been recently identified in the genome of numerous cancers. Long ncRNAs (lncRNAs) belong to a new class of ncRNAs including tens of thousands different species. A fraction of these molecules shows a striking cancer-enriched expression pattern, suggesting an essential role in tumor cells and, possibly, a utility in therapeutic terms. This review aims at summarizing current knowledge for the identification and validation of lncRNAs as therapeutics targets in tumors. Both in-silico and wet-biology resources are presented in relation to the many challenges that the scientific community still needs to address in terms of lncRNA identification, stratification, patient personalization, drug delivery and toxicity.
authors.affiliation: Division of Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy. Electronic address: giovanni.lavorgna@hsr.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lavorgna
authors.affiliation: Division of Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; Vita-Salute San Raffaele University, 20132 Milan, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Vago
authors.affiliation: Division of Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Sarmini
authors.affiliation: Division of Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; Vita-Salute San Raffaele University, 20132 Milan, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Montorsi
authors.affiliation: Division of Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; Vita-Salute San Raffaele University, 20132 Milan, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Salonia
authors.affiliation: San Raffaele Scientific Institute, Cellular Immunology Unit, Milan, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Bellone
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D064113:CRISPR-Cas Systems; D000072669:Gene Editing / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D062085:RNA, Long Noncoding / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D000067492:RNAi Therapeutics / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D062085:RNA, Long Noncoding; D034741:RNA, Small Interfering
keywords: Apoptosis; Bioinformatics; Cancer; Drug delivery; ncRNA