title: Presence of portal vein thrombosis in liver cirrhosis is strongly associated with low levels of ADAMTS-13: a pilot study.
abstract: Portal vein thrombosis (PVT) dramatically changes the prognosis of cirrhotic patients, especially those waiting for liver transplantation. However, the possible contribution to PVT of von Willebrand factor (VWF) and ADAMTS-13 is poorly documented. The aim of our study was to assess the presence of alterations of VWF and ADAMTS-13 serum levels in cirrhotic patients with PVT. Twenty-four patients with PVT (group PVT) and 60 without PVT (group without PVT) were enrolled. A comprehensive analysis of biochemical and hemostatic parameters was performed. ADAMTS-13 activity was significantly lower in group A (median 16.8 vs. 69.1 %, p = 0.0047). Group PVT, compared to group without PVT, showed a significantly higher VWF:act, (median 308.4 vs 203.3 %, p = 0.032), whereas no difference was observed for VWF:Ag, FVIII level and the presence of risk factors for venous thromboembolism. No correlation was found between the Child-Pugh score and ADAMTS-13 activity. In multivariable logistic regression analysis performed on data concerning both group PVT and without PVT, only the ADAMTS-13 activity (p = 0.007) was independently and inversely associated with PVT. In conclusion, ADAMTS-13 activity is independently associated with PVT in cirrhotic patients.
authors.affiliation: Department of Oncology and Haematology, Institute of Internal Medicine and Geriatrics, Center for Hemorrhagic and Thrombotic Diseases and Haemophilia Center, "A. Gemelli" Hospital, Catholic University School of Medicine, Largo A. Gemelli, 00168, Rome, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Lancellotti
authors.affiliation: Department of Oncology and Haematology, Institute of Internal Medicine and Geriatrics, Center for Hemorrhagic and Thrombotic Diseases and Haemophilia Center, "A. Gemelli" Hospital, Catholic University School of Medicine, Largo A. Gemelli, 00168, Rome, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Basso
authors.affiliation: Department of Oncology and Haematology, Institute of Internal Medicine and Geriatrics, Center for Hemorrhagic and Thrombotic Diseases and Haemophilia Center, "A. Gemelli" Hospital, Catholic University School of Medicine, Largo A. Gemelli, 00168, Rome, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Veca
authors.affiliation: Department of Oncology and Haematology, Institute of Internal Medicine and Geriatrics, Center for Hemorrhagic and Thrombotic Diseases and Haemophilia Center, "A. Gemelli" Hospital, Catholic University School of Medicine, Largo A. Gemelli, 00168, Rome, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Sacco
authors.affiliation: Department of Digestive, Endocrine and Metabolic System, Institute of Internal Medicine and Geriatrics, "A. Gemelli" Hospital, Catholic University School of Medicine, Rome, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Riccardi
authors.affiliation: Department of Digestive, Endocrine and Metabolic System, Institute of Internal Medicine and Geriatrics, "A. Gemelli" Hospital, Catholic University School of Medicine, Rome, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Pompili
authors.affiliation: Department of Oncology and Haematology, Institute of Internal Medicine and Geriatrics, Center for Hemorrhagic and Thrombotic Diseases and Haemophilia Center, "A. Gemelli" Hospital, Catholic University School of Medicine, Largo A. Gemelli, 00168, Rome, Italy. raimondo.decristofaro@unicatt.it.
authors.forename: Raimondo
authors.initials: R
authors.lastname: De Cristofaro
mesh_terms: D000071120:ADAMTS13 Protein / Q000032:analysis* / Q000097:blood; D000368:Aged; D001780:Blood Coagulation Tests / Q000706:statistics & numerical data; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008103:Liver Cirrhosis / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011169:Portal Vein / Q000503:physiopathology*; D012307:Risk Factors; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D014841:von Willebrand Factor; D000071120:ADAMTS13 Protein
keywords: ADAMTS-13; Cirrhosis; Portal vein thrombosis; von Willebrand factor