title: [Genetic isolates and inbreeding customs in three rural municipalities from Honduras].
abstract: BACKGROUND
  The isonymic method has been amply used to assess the approximate genetic structure of human communities. The objective of the study was to evaluate the magnitude of genetic isolation and inbreeding customs in 57 communities from three rural municipalities of Honduras using isonymy techniques.
  
  
  METHODS
  The list of 408 different surnames from 20712 voters registered in the national electoral organism, residing in the 57 Honduran communities, was used for this study. For each community, random (IR), non-random (IN), and total (IT) isonymy values were calculated in order to assess inbreeding coefficients FST, FIS and FIT.
  
  
  RESULTS
  High consanguinity due to isolation and to endogamous customs was unveiled in many communities. Significant deviation from the exogamous behavior typical of many human populations was observed in the three studied municipalities, when compared to other Honduran populations.
  
  
  CONCLUSIONS
  The studied communities present high consanguinity due to isolation, ethnic segregation and/or endogamous customs.
authors.affiliation: Facultad de Medicina, Universidad Católica de Honduras, Campus San Pedro y San Pablo, San Pedro Sula, Honduras. eherrera@unicah.edu.
authors.forename: Edwin Francisco
authors.initials: EF
authors.lastname: Herrera-Paz
mesh_terms: D003241:Consanguinity; D003430:Cross-Sectional Studies; D006721:Honduras; D006801:Humans; D007197:Indians, Central American; D009275:Names; D012424:Rural Population; D012934:Social Isolation
keywords: Consanguinity; Genetics; Names; South American Indians