title: [Gut microbiome and psyche: paradigm shift in the concept of brain-gut axis].
abstract: BACKGROUND
  The concept of the brain-gut axis describes the communication between the central and enteric nervous system. The exchange of information takes place in both directions. The great advances in molecular medicine in recent years led to the discovery of an enormous number of microorganisms in the intestine (gut microbiome), which greatly affect the function of the brain-gut axis.
  
  
  METHODS
  Overview
  
  
  CONCLUSIONS
  Numerous studies indicate that the dysfunction of the brain-gut axis could lead to both inflammatory and functional diseases of the gastrointestinal tract. Moreover, it was shown that a faulty composition of the gut microbiota in childhood influences the maturation of the central nervous system and thus may favor the development of mental disorders such as autism, depression, or other. An exact causal relationship between psyche and microbiome must be clarified by further studies in order to find new therapeutic options.
authors.affiliation: Klinik für Innere Medizin II Saalfeld, Thüringen-Kliniken, "Georgius Agricola" GmbH, Akademisches Lehrkrankenhaus der Universität Jena, Rainweg 68, 07318, Saalfeld, Deutschland. pkonturek@thueringen-kliniken.de.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Konturek
authors.affiliation: Klinik für Innere Medizin II Saalfeld, Thüringen-Kliniken, "Georgius Agricola" GmbH, Akademisches Lehrkrankenhaus der Universität Jena, Rainweg 68, 07318, Saalfeld, Deutschland.
authors.forename: Yurdagül
authors.initials: Y
authors.lastname: Zopf
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D002648:Child; D004644:Emotions / Q000502:physiology*; D017615:Enteric Nervous System / Q000503:physiopathology*; D005767:Gastrointestinal Diseases / Q000503:physiopathology*; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000294:innervation*; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology; D013315:Stress, Psychological / Q000503:physiopathology
keywords: brain-gut axis; gut microbiome; stress