title: Clinical implications of new mechanistic insights into atopic dermatitis.
abstract: The review will examine recent advances in our understanding of atopic dermatitis and how these mechanisms provide a framework for new approaches to the management of this common skin disease.
  
  
  
  The mechanisms by which epithelial skin barrier and immune responses contribute to the complex clinical phenotypes found in atopic dermatitis are being elucidated. Atopic dermatitis often precedes food allergy because reduced skin barrier function allows environmental food allergens to penetrate the skin leading to systemic allergen sensitization. There is increasing evidence that atopic dermatitis is a systemic disease. New treatments are focused on intervention in polarized immune responses leading to allergic diseases. This includes antagonism of IL-4 and IL-13 effects. Prevention strategies involve maintaining normal skin barrier function with emollients to prevent allergens and microbes from penetrating the skin.
  
  
  
  Recent work on the pathogenesis of atopic dermatitis has important implications for its clinical management, including the development of effective barrier creams and biologicals targeting specific polarized immune pathways resulting in skin inflammation.
authors.affiliation: Edelstein Family Chair of Pediatric Allergy-Immunology, National Jewish Health, Denver, Colorado, USA and Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The 2nd Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Donald Y M
authors.initials: DY
authors.lastname: Leung
mesh_terms: D000485:Allergens / Q000276:immunology*; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy*; D004643:Emollients / Q000008:administration & dosage / Q000627:therapeutic use*; D004781:Environmental Exposure / Q000517:prevention & control*; D019317:Evidence-Based Medicine; D059647:Gene-Environment Interaction; D006801:Humans; D010641:Phenotype; D063465:Skin Cream / Q000627:therapeutic use
chemical_list: D000485:Allergens; D004643:Emollients