title: The Predictors study: Development and baseline characteristics of the Predictors 3 cohort.
abstract: The Predictors study was designed to predict the length of time to major disease outcomes in Alzheimer's disease (AD) patients. Here, we describe the development of a new, Predictors 3, cohort.
  
  
  
  Patients with prevalent or incident AD and individuals at-risk for developing AD were selected from the North Manhattan community and followed annually with instruments comparable to those used in the original two Predictors cohorts.
  
  
  
  The original Predictors cohorts were clinic based and racially/ethnically homogenous (94% white, 6% black; 3% Hispanic). In contrast, the 274 elders in this cohort are community-based and ethnically diverse (39% white, 40% black, 21% other; 78% Hispanic). Confirming previous observations, psychotic features were associated with poorer function and mental status and extrapyramidal signs with poorer function.
  
  
  
  This new cohort will allow us to test observations made in our original clinic-based cohorts in patients that may be more representative of the general community.
authors.affiliation: Cognitive Neuroscience Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA. Electronic address: ys11@columbia.edu.
authors.forename: Yaakov
authors.initials: Y
authors.lastname: Stern
authors.affiliation: Cognitive Neuroscience Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
authors.forename: Yian
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Cognitive Neuroscience Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Cosentino
authors.affiliation: Cognitive Neuroscience Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
authors.forename: Martina
authors.initials: M
authors.lastname: Azar
authors.affiliation: Cognitive Neuroscience Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
authors.forename: Siobhan
authors.initials: S
authors.lastname: Lawless
authors.affiliation: Cognitive Neuroscience Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
authors.forename: Oksana
authors.initials: O
authors.lastname: Tatarina
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D015331:Cohort Studies; D003863:Depression / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D009519:New York City / Q000453:epidemiology; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D011795:Surveys and Questionnaires
keywords: ADL; Cognitive function; Extrapyramidal signs; MCI; Pharmacoeconomics; Prediction algorithms; Psychotic features