title: Correction of Motion Artifacts From Shuttle Mode Computed Tomography Acquisitions for Body Perfusion Imaging Applications.
abstract: OBJECTIVE
  The aim of this study was to investigate the feasibility of shuttle-mode computed tomography (CT) technology for body perfusion applications by quantitatively assessing and correcting motion artifacts.
  
  
  METHODS
  Noncontrast shuttle-mode CT scans (10 phases, 2 nonoverlapping bed locations) were acquired from 4 patients on a GE 750HD CT scanner. Shuttling effects were quantified using Euclidean distances (between-phase and between-bed locations) of corresponding fiducial points on the shuttle and reference phase scans (prior to shuttle mode). Motion correction with nonrigid registration was evaluated using sum-of-squares differences and distances between centers of segmented volumes of interest on shuttle and references images.
  
  
  RESULTS
  Fiducial point analysis showed an average shuttling motion of 0.85 ± 1.05 mm (between-bed) and 1.18 ± 1.46 mm (between-phase), respectively. The volume-of-interest analysis of the nonrigid registration results showed improved sum-of-squares differences from 2950 to 597, between-bed distance from 1.64 to 1.20 mm, and between-phase distance from 2.64 to 1.33 mm, respectively, averaged over all cases.
  
  
  CONCLUSIONS
  Shuttling effects introduced during shuttle-mode CT acquisitions can be computationally corrected for body perfusion applications.
authors.affiliation: From the *Department of Diagnostic Radiology, University of Texas M. D. Anderson Cancer Center, Houston TX; †GE Healthcare MICT Research, Waukesha, WI; and ‡Department of Imaging Physics, University of Texas M. D. Anderson Cancer Center, Houston TX.
authors.forename: Payel
authors.initials: P
authors.lastname: Ghosh
authors.forename: Adam G
authors.initials: AG
authors.lastname: Chandler
authors.forename: Emre
authors.initials: E
authors.lastname: Altinmakas
authors.forename: John
authors.initials: J
authors.lastname: Rong
authors.forename: Chaan S
authors.initials: CS
authors.lastname: Ng
mesh_terms: D059925:Anatomic Landmarks / Q000000981:diagnostic imaging; D016477:Artifacts; D000072226:Computed Tomography Angiography; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D009038:Motion; D056888:Patient Positioning; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D051598:Whole Body Imaging / Q000379:methods*