title: Systematic Evaluation of Drug-Loaded Hydrogels for Application in Osteosarcoma Treatment.
abstract: This is a literature review of studies focusing on the preparation of hydrogels for use as oncological drug delivery systems in the treatment of osteosarcoma (OS). The databases of the US National Library of Medicine National Institutes of Health, Embase, OVID, and Cochrane Library, and the references of retrieved studies, were traced from 1843 to December 21, 2015, without language restrictions. The obtained data were evaluated by complementary statistical methods. Potentially relevant studies were found and included in the analysis. OS-specific chemotherapeutic agents can be successfully embedded within the hydrogels and these drug-loaded hydrogels can be applied locally, rather than systemically, without organ tissue toxicity. Further, OS-specific drug-loaded hydrogels significantly increased tumor inhibition and decreased osteolysis and lung metastases. Drug-loaded hydrogels could be useful in the treatment of OS, although their development remains at the experimental phase. Following evaluation of their application in surgery and the completion of drug release kinetics studies, drug-loaded hydrogels could be tested on living mammals in large samples with the aim of applying these in clinical settings. In the future, development of such drug delivery systems and application of targeted approaches against osteosarcoma and other malignancies may render surgery, radiotherapy and chemotherapy unnecessary.
authors.forename: Seyit
authors.initials: S
authors.lastname: Ali Gumustas
authors.forename: Mehmet
authors.initials: M
authors.lastname: Isyar
authors.forename: Savas
authors.initials: S
authors.lastname: Topuk
authors.affiliation: Republic of Turkey, Ministry of Health, Department of Pharmacovigilance, Materiovigilance and Rational Use of Drugs, 59100, Tekirdag, Turkey. ibrahimyilmaz77@yahoo.com.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Yilmaz
authors.forename: Kadir
authors.initials: K
authors.lastname: Oznam
authors.forename: Tolga
authors.initials: T
authors.lastname: Onay
authors.forename: Onder
authors.initials: O
authors.lastname: Ofluoglu
authors.forename: Mahir
authors.initials: M
authors.lastname: Mahirogullari
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy*; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D012516:Osteosarcoma / Q000188:drug therapy*; D014481:United States
chemical_list: D000970:Antineoplastic Agents; D020100:Hydrogels