title: Hollow Structure Improved Anti-Cancer Immunity of Mesoporous Silica Nanospheres In Vivo.
abstract: Hollow and non-hollow mesoporous silica nanospheres are synthesized and used for cancer vaccine adjuvants. The hollow structure of mesoporous silica nanospheres significantly promote cellular uptake of a model cancer antigen by macrophage-like cells in vitro, improve anti-cancer immunity, CD4(+) and CD8(+) T cell populations in splenocytes of mice in vivo.
authors.affiliation: Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
authors.forename: Xiupeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.affiliation: Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
authors.forename: Atsuo
authors.initials: A
authors.lastname: Ito
authors.affiliation: Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Yoshiyuki
authors.affiliation: Health Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sogo
authors.affiliation: Biomedical Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Department of Resources and Environmental Engineering, Waseda University, Shinjuku-ku, Tokyo, 169-8555, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamazaki
authors.affiliation: School of Life Dentistry at Tokyo, The Nippon Dental University, Fujimi, Chiyoda-ku, Tokyo, 102-0071, Japan.
authors.forename: Tadao
authors.initials: T
authors.lastname: Ohno
authors.affiliation: Biomedical Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
authors.forename: Noriko M
authors.initials: NM
authors.lastname: Tsuji
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000737:chemistry*; D000818:Animals; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D051379:Mice; D064347:Microscopy, Electrochemical, Scanning; D046529:Microscopy, Electron, Transmission; D041681:NIH 3T3 Cells; D054118:Nanospheres / Q000009:adverse effects / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000276:Adjuvants, Immunologic; D019496:Cancer Vaccines; D012822:Silicon Dioxide
keywords: cancer immunoadjuvant; hollow structures; mesoporous silica nanospheres