title: Inverse correlation between longevity and developmental rate among wild C. elegans strains.
abstract: Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness in wild organisms remains inconclusive. Here, we determined the correlation between lifespan and fitness, developmental rate and brood size, by using 16 wild-derived C. elegans strains originated from various geographic areas. We found a negative correlation between lifespan and developmental rate. In contrast, we did not find such negative correlation between longevity and developmental rate among the individuals of C. elegans strains. These data imply that polymorphic genetic variants among wild isolates determine resource allocation to longevity and developmental rate.
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
authors.forename: Yujin
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
authors.forename: Wooseon
authors.initials: W
authors.lastname: Hwang
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
authors.forename: Juyoung
authors.initials: J
authors.lastname: Jung
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
authors.forename: Sangsoon
authors.initials: S
authors.lastname: Park
authors.affiliation: Asia Pacific Center for Theoretical Physics, Pohang, Gyeongbuk, South Korea.
authors.forename: Josephine Jill T
authors.initials: JJ
authors.lastname: Cabatbat
authors.affiliation: Asia Pacific Center for Theoretical Physics, Pohang, Gyeongbuk, South Korea.|Department of Physics, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
authors.forename: Pan-Jun
authors.initials: PJ
authors.lastname: Kim
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.|School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.|Information Technology Convergence Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
authors.forename: Seung-Jae V
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D008136:Longevity / Q000235:genetics*; D013045:Species Specificity
keywords: C. elegans; aging; development; fitness; lifespan; reproduction