title: A Randomized Controlled Study of Mineral Trioxide Aggregate and Super Ethoxybenzoic Acid as Root-end Filling Materials in Endodontic Microsurgery: Long-term Outcomes.
abstract: BACKGROUND
  The purpose of the present study was to evaluate the long-term clinical outcome of endodontic microsurgery when mineral trioxide aggregate (MTA) and super ethoxybenzoic acid (Super EBA; Harry J. Bosworth, Skokie, IL) were used as root-end filling materials. Additionally, this study aimed to compare the clinical outcome of endodontic microsurgery at the 1-year follow-up with that at the 4-year follow-up.
  
  
  METHODS
  Two hundred sixty teeth were randomly assigned to either the MTA or Super EBA group in equal numbers using the minimization method. Endodontic microsurgery was performed according to the Yonsei protocol. The previous study of 192 teeth examined at the 1-year follow-up revealed a success rate of 95.6% for MTA and 93.1% for Super EBA. Patients were recalled 4 years after surgery, and treated teeth were classified as successes or failures with Molven's criteria. The Pearson chi-square test and the McNemar test were conducted to analyze and compare the success rates.
  
  
  RESULTS
  A total of 182 teeth were examined at the 4-year follow-up. The success rate was 91.6% for MTA and 89.9% for Super EBA. Statistical analysis of the success rate did not show any significant difference between the 2 materials (P = .8). The overall success rate at the 4-year follow-up was 89.5%, which was slightly lower compared with 94.3% at the 1-year follow-up. However, there was no significant difference between the follow-up periods (P = .063).
  
  
  CONCLUSIONS
  This study identified no significant difference in the 4-year success rates of MTA and Super EBA as root-end filling materials in endodontic microsurgery. Additionally, compared with short-term outcomes, long-term follow-up outcomes were not significantly different.
authors.affiliation: Department of Conservative Dentistry, Gangnam Severance Dental Hospital, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Sunil
authors.initials: S
authors.lastname: Kim
authors.affiliation: Division of Constitutive and Regenerative Sciences Section of Restorative Dentistry, School of Dentistry, University of California, Los Angeles, Los Angeles, California.
authors.forename: Minju
authors.initials: M
authors.lastname: Song
authors.affiliation: Department of Conservative Dentistry, Gangnam Severance Dental Hospital, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Su-Jung
authors.initials: SJ
authors.lastname: Shin
authors.affiliation: Microscope Center, Department of Conservative Dentistry and Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, South Korea. Electronic address: andyendo@yuhs.ac.
authors.forename: Euiseong
authors.initials: E
authors.lastname: Kim
mesh_terms: D000328:Adult; D017607:Aluminum Compounds / Q000627:therapeutic use*; D017610:Calcium Compounds / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D062425:Hydroxybenzoate Ethers / Q000627:therapeutic use*; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D010087:Oxides / Q000627:therapeutic use*; D010485:Periapical Periodontitis / Q000601:surgery*; D012387:Root Canal Filling Materials / Q000627:therapeutic use*; D012390:Root Canal Therapy / Q000379:methods*; D017640:Silicates / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D062425:Hydroxybenzoate Ethers; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; C015199:ethoxybenzoic acid
keywords: Clinical outcome; endodontic microsurgery; mineral trioxide aggregate; randomized clinical trial; root-end filling material; success rate; super ethoxybenzoic acid