title: The In Vitro and In Vivo Wound Healing Properties of the Chinese Herbal Medicine "Jinchuang Ointment".
abstract: "Jinchuang ointment" is a traditional Chinese herbal medicine complex for treatment of incised wounds. For more than ten years, it has been used at China Medical University Hospital (Taichung, Taiwan) for the treatment of diabetic foot infections and decubitus ulcers. Three different cases are presented in this study. "Jinchuang" ointment is a mixture of natural product complexes from nine different components, making it difficult to analyze its exact chemical compositions. To further characterize the herbal ingredients used in this study, the contents of reference standards present in a subset of the ointment ingredients (dragon's blood, catechu, frankincense, and myrrh) were determined by HPLC. Two in vitro cell based assay platforms, wound healing and tube formation, were used to examine the biological activity of this medicine. Our results show that this herbal medicine possesses strong activities including stimulation of angiogenesis, cell proliferation, and cell migration, which provide the scientific basis for its clinically observed curative effects on nonhealing diabetic wounds.
authors.affiliation: Division of Chinese Medicine, China Medical University Beigang Hospital, Yulin 65152, Taiwan; Division of Chinese Medicine, An Nan Hospital, China Medical University, Tainan 70965, Taiwan; College of Chinese Medicine, China Medical University, Taichung 40421, Taiwan.
authors.forename: Tsung-Jung
authors.initials: TJ
authors.lastname: Ho
authors.affiliation: Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
authors.forename: Shinn-Jong
authors.initials: SJ
authors.lastname: Jiang
authors.affiliation: Department of Microbiology, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
authors.forename: Guang-Huey
authors.initials: GH
authors.lastname: Lin
authors.affiliation: Department of Plastic Surgery, China Medical University Beigang Hospital, Yulin 65152, Taiwan; School of Medicine, China Medical University, Taichung 40421, Taiwan; Department of Plastic Surgery, China Medical University Hospital, Taichung 40447, Taiwan.
authors.forename: Tzong Shiun
authors.initials: TS
authors.lastname: Li
authors.affiliation: Department of Public Health, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
authors.forename: Lih-Ming
authors.initials: LM
authors.lastname: Yiin
authors.affiliation: Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan.
authors.forename: Jai-Sing
authors.initials: JS
authors.lastname: Yang
authors.affiliation: Department of Microbiology, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
authors.forename: Ming-Chuan
authors.initials: MC
authors.lastname: Hsieh
authors.affiliation: Division of Chinese Medicine, China Medical University Beigang Hospital, Yulin 65152, Taiwan.
authors.forename: Chun-Chang
authors.initials: CC
authors.lastname: Wu
authors.affiliation: Graduate Institute of Chinese Medicine, China Medical University, Taichung 40421, Taiwan.
authors.forename: Jaung-Geng
authors.initials: JG
authors.lastname: Lin
authors.affiliation: Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
authors.forename: Hao-Ping
authors.initials: HP
authors.lastname: Chen