title: The Effects of Cigarette Smoke Condensate and Nicotine on Periodontal Tissue in a Periodontitis Model Mouse.
abstract: Cigarette smoking is a major lifestyle-related risk factor for periodontal diseases. However, the pathophysiological role of cigarette smoking in periodontal disease has yet to be fully elucidated. Here we report that the systemic administration of cigarette smoke condensate or nicotine, which is the major ingredient of cigarette smoke, augmented alveolar bone loss. Concomitantly, the number of osteoclasts in periodontal tissues increased and the expression of receptor activator of nuclear factor κB ligand was upregulated at the ligated side in mice with periodontitis. Nicotine also attenuated alveolar bone repair after ligature removal. These observations highlight the destruction of periodontal tissue by smoking and the unfavorable clinical course of periodontal disease in patients with a cigarette smoking habit. The present study demonstrates that periodontal disease models are useful for elucidating the pathogenesis of cigarette smoking-related periodontal diseases.
authors.affiliation: Division of Oral Biology and Disease Control, Department of Periodontology, Osaka University, Suita, Osaka, Japan.
authors.forename: Mikiko
authors.initials: M
authors.lastname: Kubota
authors.affiliation: Division of Oral Biology and Disease Control, Department of Periodontology, Osaka University, Suita, Osaka, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Yanagita
authors.affiliation: Division of Oral Biology and Disease Control, Department of Periodontology, Osaka University, Suita, Osaka, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Mori
authors.affiliation: Division of Oral Biology and Disease Control, Department of Periodontology, Osaka University, Suita, Osaka, Japan.
authors.forename: Shiori
authors.initials: S
authors.lastname: Hasegawa
authors.affiliation: Division of Oral Biology and Disease Control, Department of Periodontology, Osaka University, Suita, Osaka, Japan.
authors.forename: Motozo
authors.initials: M
authors.lastname: Yamashita
authors.affiliation: Division of Oral Biology and Disease Control, Department of Periodontology, Osaka University, Suita, Osaka, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamada
authors.affiliation: Division of Oral Biology and Disease Control, Department of Periodontology, Osaka University, Suita, Osaka, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kitamura
authors.affiliation: Division of Oral Biology and Disease Control, Department of Periodontology, Osaka University, Suita, Osaka, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Murakami
mesh_terms: D016301:Alveolar Bone Loss / Q000139:chemically induced*; D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D008810:Mice, Inbred C57BL; D009538:Nicotine / Q000009:adverse effects*; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects; D010510:Periodontal Diseases / Q000139:chemically induced* / Q000473:pathology; D010519:Periodontium / Q000187:drug effects / Q000473:pathology; D053245:RANK Ligand / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D012907:Smoking / Q000009:adverse effects*; D000071681:Tartrate-Resistant Acid Phosphatase / Q000378:metabolism; D055114:X-Ray Microtomography
chemical_list: D053245:RANK Ligand; C505689:Tnfsf11 protein, mouse; D009538:Nicotine; D000071681:Tartrate-Resistant Acid Phosphatase