title: New [(η(5)-C5H5)Ru(N-N)(PPh3)][PF6] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes.
abstract: Eight ruthenium(ii) compounds of the general formula [(η(5)-C5H5)Ru(N-N)(PPh3)][PF6] were rationally designed, exhibiting high cytotoxicity against HCT116 human colon cancer cells, with IC50 between 14.56 and 1.56 μM; importantly, compounds 5Ru and 6Ru are the first reported ruthenium glycoconjugates exploiting glucose transporters, widely overexpressed in cancer, for cellular uptake.
authors.affiliation: Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal. anacristinafernandes@tecnico.ulisboa.pt pedro.florindo@tecnico.ulisboa.pt.
authors.forename: Pedro R
authors.initials: PR
authors.lastname: Florindo
authors.affiliation: Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
authors.forename: Diane M
authors.initials: DM
authors.lastname: Pereira
authors.affiliation: Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
authors.forename: Pedro M
authors.initials: PM
authors.lastname: Borralho
authors.affiliation: Centro de Química e Bioquímica, DQB, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.
authors.forename: Paulo J
authors.initials: PJ
authors.lastname: Costa
authors.affiliation: Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal. anacristinafernandes@tecnico.ulisboa.pt pedro.florindo@tecnico.ulisboa.pt and Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.
authors.forename: M F M
authors.initials: MF
authors.lastname: Piedade
authors.affiliation: Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
authors.forename: Cecília M P
authors.initials: CM
authors.lastname: Rodrigues
authors.affiliation: Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal. anacristinafernandes@tecnico.ulisboa.pt pedro.florindo@tecnico.ulisboa.pt.
authors.forename: Ana C
authors.initials: AC
authors.lastname: Fernandes
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D001692:Biological Transport; D002241:Carbohydrates / Q000737:chemistry*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D056831:Coordination Complexes / Q000737:chemistry / Q000627:therapeutic use*; D045325:HCT116 Cells; D006801:Humans; D008958:Models, Molecular; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D017975:Ruthenium Compounds / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D002241:Carbohydrates; D056831:Coordination Complexes; D009004:Monosaccharide Transport Proteins; D017975:Ruthenium Compounds