title: Susac's syndrome: Leptomeningeal enhancement on 3D FLAIR MRI.
abstract: Contrast-enhanced (ce) fluid-attenuated inversion recovery magnetic resonance imaging (FLAIR MRI) has recently been shown to identify leptomeningeal pathology in multiple sclerosis.
  
  
  
  To demonstrate leptomeningeal enhancement on three-dimensional (3D) FLAIR in a case of Susac's syndrome.
  
  
  
  Leptomeningeal enhancement was correlated with clinical activity over 20 months and compared to retinal fluorescein angiography.
  
  
  
  The size, number, and location of leptomeningeal enhancement varied over time and generally correlated with symptom severity. The appearance was remarkably similar to that of retinal vasculopathy.
  
  
  
  Ce 3D FLAIR may aid in diagnosis and understanding of pathophysiology in Susac's syndrome and may serve as a biomarker for disease activity.
authors.affiliation: Institute of Diagnostic and Interventional Neuroradiology, Bern University Hospital, Bern, Switzerland renate.engisch@insel.ch.
authors.forename: Renate
authors.initials: R
authors.lastname: Engisch
authors.affiliation: Shields Healthcare, Brockton, MA, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Titelbaum
authors.affiliation: Department of Neurology, Bern University Hospital, Bern, Switzerland.
authors.forename: Lara
authors.initials: L
authors.lastname: Chilver-Stainer
authors.affiliation: Institute of Diagnostic and Interventional Neuroradiology, Bern University Hospital, Bern, Switzerland.
authors.forename: Frauke
authors.initials: F
authors.lastname: Kellner-Weldon
mesh_terms: D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage; D005451:Fluorescein Angiography; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008578:Meninges / Q000000981:diagnostic imaging* / Q000187:drug effects; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D013256:Steroids / Q000008:administration & dosage; D055955:Susac Syndrome / Q000000981:diagnostic imaging* / Q000188:drug therapy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D013256:Steroids
keywords: Susac’s syndrome; contrast-enhanced FLAIR; leptomeningeal pathology