title: Chronological clinical and pathological documentation of porcine ulcerative dermatitis.
abstract: BACKGROUND
  Porcine ulcerative dermatitis syndrome (PUDS) is a rare disease of breeding sows with an unknown pathogenesis.
  
  
  OBJECTIVE
  To describe the evolution of clinical and histopathological lesions over the course of the disease and to elucidate the pathogenesis.
  
  
  METHODS
  A 24-month-old, pluriparous, large white sow presented during gestation with ulcerations around the teats compatible with PUDS.
  
  
  RESULTS
  Clinical and histopathological lesions were monitored over the course of the disease (i.e. during and after the subsequent pregnancy). A clear gestation-dependent flare of the lesions was observed with partial resolution occurring postpartum. The histological pattern presented as a lymphocytic interface dermatitis.
  
  
  CONCLUSIONS
  The findings in this case report link gestation with the development of clinical signs and histological changes. Multiparity appears to enhance severity and may finally result in a self-perpetuating disease. Therefore, it seems advisable to cull breeding sows after they have developed PUDS.
authors.affiliation: Department of Clinical Veterinary Medicine, Clinic for Swine, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109A, 3012, Bern, Switzerland.
authors.forename: Friederike
authors.initials: F
authors.lastname: Zeeh
authors.affiliation: Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, PO Box 8466, 3001, Bern, Switzerland.|DermFocus, Vetsuisse Faculty, University of Bern, PO Box 8466, 3001, Bern, Switzerland.
authors.forename: Maja M
authors.initials: MM
authors.lastname: Suter
authors.affiliation: Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, PO Box 8466, 3001, Bern, Switzerland.|DermFocus, Vetsuisse Faculty, University of Bern, PO Box 8466, 3001, Bern, Switzerland.
authors.forename: Eliane
authors.initials: E
authors.lastname: Mueller
authors.affiliation: Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, PO Box 8466, 3001, Bern, Switzerland.|DermFocus, Vetsuisse Faculty, University of Bern, PO Box 8466, 3001, Bern, Switzerland.
authors.forename: Natalia
authors.initials: N
authors.lastname: Brünisholz
authors.affiliation: Department of Clinical Veterinary Medicine, Clinic for Swine, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109A, 3012, Bern, Switzerland.
authors.forename: Werner
authors.initials: W
authors.lastname: Zimmerman
authors.affiliation: Division of Clinical Dermatology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, PO Box 8466, 3001, Bern, Switzerland.
authors.forename: Meret
authors.initials: M
authors.lastname: Ricklin
authors.affiliation: Division of Clinical Dermatology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, PO Box 8466, 3001, Bern, Switzerland.
authors.forename: Silvia
authors.initials: S
authors.lastname: Rüfenacht
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, NC, 27607, USA.
authors.forename: Thierry
authors.initials: T
authors.lastname: Olivry
authors.affiliation: DermFocus, Vetsuisse Faculty, University of Bern, PO Box 8466, 3001, Bern, Switzerland.|Division of Clinical Dermatology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, PO Box 8466, 3001, Bern, Switzerland.
authors.forename: Petra J
authors.initials: PJ
authors.lastname: Roosje