title: A combination of soy isoflavones and cello-oligosaccharides changes equol/O-desmethylangolensin production ratio and attenuates bone fragility in ovariectomized mice.
abstract: We examined the cooperative effects of isoflavones and cello-oligosaccharides on daidzein metabolism and bone fragility in ovariectomized mice. Cello-oligosaccharides increased urinary equol and decreased O-desmethylangolensin. A combination of isoflavones and cello-oligosaccharides attenuated decreases in bone breaking force and stiffness caused by ovariectomy. Combination treatment with isofalvones and cello-oligosaccharides increases urinary equol/O-desmethylangolensin production ratio and prevents ovariectomy-induced abnormalities in bone strength.
authors.affiliation: a Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Shungo
authors.initials: S
authors.lastname: Fujii
authors.affiliation: a Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takahashi
authors.affiliation: a Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Inoue
authors.affiliation: b Faculty of Applied Bioscience, Department of Nutritional Science , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Katsumata
authors.affiliation: c Nippon Paper Industries Co., Ltd. , Tokyo , Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kikkawa
authors.affiliation: c Nippon Paper Industries Co., Ltd. , Tokyo , Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Machida
authors.affiliation: d Department of Food Function and Labeling , National Institute of Health and Nutrition , Tokyo , Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Ishimi
authors.affiliation: a Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Uehara
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D002475:Cellobiose / Q000008:administration & dosage*; D060754:Equol / Q000652:urine*; D005260:Female; D005269:Femur / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005526:Food, Formulated; D050723:Fractures, Bone / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D019833:Genistein / Q000652:urine; D007529:Isoflavones / Q000008:administration & dosage* / Q000652:urine; D051379:Mice; D010052:Ovariectomy; D013025:Glycine max / Q000737:chemistry
chemical_list: D007529:Isoflavones; D002475:Cellobiose; D060754:Equol; C004742:daidzein; D019833:Genistein; C050052:O-desmethylangolensin
keywords: O-desmethylangolensin; cello-oligosaccharides; equol; isoflavones; osteoporosis