title: [Efficacy of Ipragliflozin in Patients with Steroid-Induced Hyperglycemia during Cancer Chemotherapy].
abstract: Steroid is a key drug in cancer chemotherapy-induced emesis. However, it may sometimes cause inadequately controlled hyperglycemia. Ipragliflozin is a novel selective sodium-dependent glucose cotransporter 2 inhibitor of urinary glucose excretion. In this case, we controlled steroid-induced hyperglycemia by administering ipragliflozin. The case was a 47-year-old man who was diagnosed with Stage IV esophageal cancer (T3N2M1). He had type 2 diabetes. He was treated with cisplatin (70 mg/m2; day 1) and 5-FU (700 mg/m2; days 1-4) as radiochemotherapy. Intravenous infusion of dexamethasone (9.9 mg) was administered on day 1, followed by additional doses (6.6 mg) for 3 days, as one of the emetic therapies. He received intensive insulin therapy during the first course of chemotherapy, but had Grade 3 hyperglycemia regardless. For the next treatment course, we additionally administered ipragliflozin along with dexamethasone. As a result, the hyperglycemia subsided to Grade 2. These findings suggest that ipragliflozin suppresses steroid-induced hyperglycemia.
authors.affiliation: Dept. of Pharmacy, National Cancer Center Hospital East.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Horasawa
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Osame
authors.forename: Kenji
authors.initials: K
authors.lastname: Kawasumi
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Saito
authors.forename: Hideaki
authors.initials: H
authors.lastname: Bando
authors.forename: Ken
authors.initials: K
authors.lastname: Ohashi
mesh_terms: D000932:Antiemetics / Q000008:administration & dosage*; D001786:Blood Glucose / Q000032:analysis; D059248:Chemoradiotherapy; D003907:Dexamethasone / Q000009:adverse effects*; D004938:Esophageal Neoplasms / Q000473:pathology / Q000628:therapy*; D005960:Glucosides / Q000627:therapeutic use*; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013876:Thiophenes / Q000627:therapeutic use*
chemical_list: D000932:Antiemetics; D001786:Blood Glucose; D005960:Glucosides; D013876:Thiophenes; C572941:ipragliflozin; D003907:Dexamethasone