title: Micronucleus as biomarkers of cancer risk in anabolic androgenic steroids users.
abstract: The use of anabolic androgenic steroids (AAS) has grown among practitioners of recreational bodybuilding, with significant contributions of designer steroids, aiming muscle hypertrophy in healthy subjects. The abusive use of AAS in general is associated with adverse effects; one of the most worrisome is cancer development. The aim of this study was to evaluate the effectiveness of the cytokinesis block micronucleus (CBMN) test in human lymphocytes in identifying risk groups for cancer development in users of AAS. Blood was collected from 15 AAS users bodybuilders (G1), 20 non-users bodybuilders (G2) and 20 non-users sedentary (G3). MN analysis was performed on a minimum of 1000 binucleated lymphocytes. The occurrence of MN was significantly higher ( p < 0.05) in individuals of G1 compared to G2 and G3. The results indicate the sensitivity of CBMN in human lymphocytes in the identification of chromosomal damage in consequence of AAS.
authors.affiliation: Department of Biological Sciences, Feira de Santana State University, Bahia, Brazil.
authors.forename: L da Cunha Menezes
authors.initials: LD
authors.lastname: Souza
authors.affiliation: Department of Biological Sciences, Feira de Santana State University, Bahia, Brazil.
authors.forename: L A
authors.initials: LA
authors.lastname: da Cruz
authors.affiliation: Department of Biological Sciences, Feira de Santana State University, Bahia, Brazil.
authors.forename: E de Moraes Marcílio
authors.initials: EM
authors.lastname: Cerqueira
authors.affiliation: Department of Biological Sciences, Feira de Santana State University, Bahia, Brazil.
authors.forename: Jrc
authors.initials: J
authors.lastname: Meireles
mesh_terms: D000328:Adult; D045930:Anabolic Agents / Q000009:adverse effects*; D001938:Brazil; D006801:Humans; D008297:Male; D015162:Micronucleus Tests; D009369:Neoplasms / Q000139:chemically induced*; D012307:Risk Factors; D013256:Steroids / Q000009:adverse effects*; D014891:Weight Lifting; D055815:Young Adult
chemical_list: D045930:Anabolic Agents; D013256:Steroids
keywords: Anabolic androgenic steroids; designer steroids; lymphocytes; micronucleus