title: Unexpected Metabolic Reactions and Secondary Targets of Pesticide Action.
abstract: Pesticides provide a fascinating combination of substituents not present in other environmental chemicals, leading to unexpected metabolites and toxicological effects in pests, mammals, and other organisms. The parent compound and/or metabolites of some pesticides have multiple targets, requiring identification of the causal agents and their modes of action. This review considers a few of the author's observations in the past six decades, some solved and others still puzzling. It illustrates that a new substituent combination not only confers specific chemical and physical properties to a class of compounds but often yields metabolites with a surprising variety of biological activities. Examples considered include proinsecticides, procyclic phosphates, CYP inhibitors as synergists, thiocarbamate sulfoxides, promutagens, carcinogens, and hepatotoxins, and stress tolerance inducers in plants. Although the discoveries considered are based on pesticide toxicology, they are broadly applicable to environmental toxicology and xenobiotics in animals, plants, and microorganisms.
authors.affiliation: Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy, and Management, 114 Wellman Hall, University of California , Berkeley, California 94720-3112, United States.
authors.forename: John E
authors.initials: JE
authors.lastname: Casida
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D004785:Environmental Pollutants / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D015394:Molecular Structure; D010575:Pesticides / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D004785:Environmental Pollutants; D010575:Pesticides
keywords: environmental toxicology; metabolic reactions; pesticides; proinsecticides; xenobiotics