title: Designing exercise clinical trials for older adults with cancer: Recommendations from 2015 Cancer and Aging Research Group NCI U13 Meeting.
abstract: Cancer and its treatment can lead to a myriad of adverse events and negatively impact quality of life of older cancer patients and survivors. Unmet physical activity needs vary across the cancer continuum and remain an important yet understudied area of research in this population. Exercise interventions have been shown to be effective in treating both the physical and psychological declines associated with cancer and its treatment, with a potential to improve cancer-related outcomes. Despite the current evidence, exercise is clearly underutilized due to several barriers and knowledge gaps in existing trials that include appropriate population identification, design, and outcome measures selection. The benefits of regular exercise in both the primary and secondary prevention of chronic conditions are well established in the non-cancer population. In older cancer patients and survivors, further research is needed before exercise gains widespread acceptance. The Cancer and Aging Research Group convened experts in exercise, aging and cancer to evaluate current scientific evidence and knowledge gaps in geriatric exercise oncology. This report summarizes these findings and provides future research directions.
authors.affiliation: Medical College of Wisconsin, Froedtert Clinical Cancer Center, Department of Medicine, Division of Medical Oncology, Milwaukee, WI, USA. Electronic address: dkilari@mcw.edu.
authors.forename: Deepak
authors.initials: D
authors.lastname: Kilari
authors.affiliation: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Cancer Care in the Elderly Clinic, Department of Geriatrics, Mexico City, Mexico.
authors.forename: Enrique
authors.initials: E
authors.lastname: Soto-Perez-de-Celis
authors.affiliation: University of Rochester Medical Center, Wilmot Cancer Institute, Department of Medicine, Division of Medical Oncology, Rochester, NY, USA.
authors.forename: Supriya Gupta
authors.initials: SG
authors.lastname: Mohile
authors.affiliation: University Health Network and University of Toronto, Department of Medicine, Toronto, Ontario, Canada.
authors.forename: Shabbir M H
authors.initials: SM
authors.lastname: Alibhai
authors.affiliation: Yale School of Medicine, Yale Cancer Center, Department of Medicine, Division of Medical Oncology, New Haven, CT, USA.
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Presley
authors.affiliation: Washington University, Department of Medicine, Division of Medical Oncology, St. Louis, MO, USA.
authors.forename: Tanya M
authors.initials: TM
authors.lastname: Wildes
authors.affiliation: Wake Forrest School of Medicine, Department of Medicine, Section of Hematology and Oncology, Winston-Salem, NC, USA.
authors.forename: Heidi D
authors.initials: HD
authors.lastname: Klepin
authors.affiliation: University of Alabama at Birmingham Comprehensive Cancer Center, Division of Cancer Control and Prevention, Birmingham, AL, USA.
authors.forename: Wendy
authors.initials: W
authors.lastname: Demark-Wahnefried
authors.affiliation: Mayo Clinic, Department of Oncology, Division of Medical Oncology, Rochester, MN, USA.
authors.forename: Amina
authors.initials: A
authors.lastname: Jatoi
authors.affiliation: University of Rochester Medical Center, SCOREboard, Rochester, NY, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Harrison
authors.affiliation: Memorial Sloan-Kettering Cancer Center, Department of Medicine, Division of Medical Oncology, New York, NY, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Won
authors.affiliation: University of Rochester Medical Center, Wilmot Cancer Institute, Department of Surgery, Division of Cancer Control, Rochester, NY, USA.
authors.forename: Karen M
authors.initials: KM
authors.lastname: Mustian
mesh_terms: D000367:Age Factors; D000368:Aged; D015444:Exercise; D005853:Geriatrics / Q000379:methods / Q000639:trends; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D008495:Medical Oncology / Q000379:methods / Q000639:trends; D009369:Neoplasms / Q000523:psychology / Q000628:therapy*; D017063:Outcome Assessment, Health Care; D018579:Patient Selection; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012107:Research Design
keywords: Cancer; Exercise; Geriatric recommendations; Older patients