title: A Convenient Synthesis of 3,7'-Bisindole Derivatives.
abstract: An efficient and convenient method to synthesize highly functionalized 3,7'-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione derivatives in ethanol-based solvents at room temperature. This strategy provides an efficient, environmentally friendly approach for easy access to various novel 3,7'-bisindole derivatives in moderate to good yields.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. 15284404381@163.com.
authors.forename: Teng
authors.initials: T
authors.lastname: Liu
authors.affiliation: Guangdong Goodscend Pharm. Sci &amp;Tech. Co., Ltd., Shantou 650091, China. hyzhu@ynu.edu.cn.
authors.forename: Hong-You
authors.initials: HY
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. L983189022@163.com.
authors.forename: Da-Yun
authors.initials: DY
authors.lastname: Luo
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. yansj@ynu.edu.cn.
authors.forename: Sheng-Jiao
authors.initials: SJ
authors.lastname: Yan
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. linjun@ynu.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; D007097:Imines; D007211:Indoles; D009570:Nitriles; D012997:Solvents; C000591102:ketenimine; C030374:indole
keywords: 3,7′-bisindoles; Michael addition; condensation reaction; heterocyclic ketene aminals