title: Microarray data on altered transcriptional program of Phgdh-deficient mouse embryonic fibroblasts caused by ʟ-serine depletion.
abstract: Inherent ʟ-Ser deficiency culminates in intrauterine growth retardation, severe malformation of multiple organs particularly the central nervous system, and perinatal or early postnatal death in human and mouse. To uncover the molecular mechanisms underlying the growth-arrested phenotypes of l-Ser deficiency, we compared gene expression profiles of mouse embryonic fibroblasts deficient in 3-phosphoglycerate dehydrogenase (Phgdh), the first enzyme of de novo ʟ-Ser synthetic pathway, between ʟ-Ser-depleted and -supplemented conditions. The datasets (CEL and CHP files) from this study are publicly available on the Gene Expression Omnibus repository (accession number GEO: GSE55687).
authors.affiliation: Laboratory of Functional Genomics and Metabolism, Departments of Innovative Science and Technology for Bio-industry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan; International College of Arts and Sciences, Fukuoka Women׳s University, Fukuoka 813-8529, Japan.
authors.forename: Momoko
authors.initials: M
authors.lastname: Hamano
authors.affiliation: Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Sayano
authors.affiliation: Laboratory of Functional Genomics and Metabolism, Departments of Innovative Science and Technology for Bio-industry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Kusada
authors.affiliation: Corporate Sponsored Research Program "Food for Life", Organization for Interdisciplinary Research Projects, The University of Tokyo, Tokyo 113-8657, Japan.
authors.forename: Hisanori
authors.initials: H
authors.lastname: Kato
authors.affiliation: Laboratory of Functional Genomics and Metabolism, Departments of Innovative Science and Technology for Bio-industry, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan; Innovative Bio-Architecture Center, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Furuya
keywords: Inborn error; Microarray; Neu-Laxova syndrome; PHGDH; Serine