title: Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious.
abstract: Sepsis, an overwhelming inflammatory response syndrome secondary to infection, is one of the costliest and deadliest medical conditions worldwide. Neutrophils are classically considered to be essential players in the host defense against invading pathogens. However, several investigations have shown that impairment of neutrophil migration to the site of infection, also referred to as neutrophil paralysis, occurs during severe sepsis, resulting in an inability of the host to contain and eliminate the infection. On the other hand, the neutrophil antibacterial arsenal contributes to tissue damage and the development of organ dysfunction during sepsis. In this review, we provide an overview of the main events in which neutrophils play a beneficial or deleterious role in the outcome of sepsis.
authors.affiliation: Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo , Ribeirão Preto , Brazil.
authors.forename: Fabiane
authors.initials: F
authors.lastname: Sônego
authors.affiliation: Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo , Ribeirão Preto , Brazil.
authors.forename: Fernanda Vargas E Silva
authors.initials: FV
authors.lastname: Castanheira
authors.affiliation: Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo , Ribeirão Preto , Brazil.
authors.forename: Raphael Gomes
authors.initials: RG
authors.lastname: Ferreira
authors.affiliation: Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo , Ribeirão Preto , Brazil.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Kanashiro
authors.affiliation: Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo , Ribeirão Preto , Brazil.
authors.forename: Caio Abner Vitorino Gonçalves
authors.initials: CA
authors.lastname: Leite
authors.affiliation: Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo , Ribeirão Preto , Brazil.
authors.forename: Daniele Carvalho
authors.initials: DC
authors.lastname: Nascimento
authors.affiliation: Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo , Ribeirão Preto , Brazil.
authors.forename: David Fernando
authors.initials: DF
authors.lastname: Colón
authors.affiliation: Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo , Ribeirão Preto , Brazil.
authors.forename: Vanessa de Fátima
authors.initials: Vde F
authors.lastname: Borges
authors.affiliation: Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo , Ribeirão Preto , Brazil.
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Alves-Filho
authors.affiliation: Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo , Ribeirão Preto , Brazil.
authors.forename: Fernando Queiróz
authors.initials: FQ
authors.lastname: Cunha
keywords: chemotactic receptors; neutrophil migration; organ dysfunction; sepsis; toll-like receptors