title: Low-Dose Isotretinoin: An Option for Difficult-to-Treat Papulopustular Rosacea.
abstract: Rosacea is a chronic disease with a profound impact on quality of life. Although there are a range of treatments for its many manifestations, some cases are difficult to treat. Sbidian et al. show in this double-blind, randomized, placebo-controlled trial that low-dose isotretinoin can be effective in treating difficult-to-treat and frequently relapsing papulopustular rosacea.
authors.affiliation: Department of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands. Electronic address: e.j.van_zuuren@lumc.nl.
authors.forename: Esther J
authors.initials: EJ
authors.lastname: van Zuuren
authors.affiliation: Cochrane Bahrain, Awali, Bahrain.
authors.forename: Zbys
authors.initials: Z
authors.lastname: Fedorowicz
mesh_terms: D017322:Clinical Trials, Phase II as Topic; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008297:Male; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D018570:Risk Assessment; D012393:Rosacea / Q000175:diagnosis* / Q000188:drug therapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D007641:Keratolytic Agents; D015474:Isotretinoin