title: Lipid Nanoparticles to Deliver miRNA in Cancer.
abstract: MicroRNAs (miRNAs) are a class of post-transcriptional gene expression modulators. In the past two decades, over 1500 human miRNAs were discovered. These small non-coding RNAs regulate various biological processes, including cell growth, proliferation, differentiation, and cell death. Thus, miRNAs have been proposed as new therapeutical agents in different multifactorial diseases such as cancer. Since miRNAs therapies represent a great promise, many research studies have been focused on the development of delivery strategies to overcome miRNAs biopharmaceutical issues. Lipid delivery systems are undoubtedly the non-viral carriers most largely investigated due to their biocompatibility, biodegradability, easy production, low toxicity and immunogenicity, possibility to easily modify the carriers for targeting strategies. In this mini-review we provide a rapid and updated overview on the lipid delivery system currently used to deliver miRNAs, pointing out the progresses achieved in the optimization of these nanovectors, which led up to the first clinical trial.
authors.forename: Virginia
authors.initials: V
authors.lastname: Campani
authors.affiliation: Department of Pharmacy, University Federico II of Naples, Naples, Italy. gderosa@unina.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Rosa
authors.forename: Gabriella
authors.initials: G
authors.lastname: Misso
authors.forename: Mayra R
authors.initials: MR
authors.lastname: Zarone
authors.forename: Anna
authors.initials: A
authors.lastname: Grimaldi
mesh_terms: D049109:Cell Proliferation; D015870:Gene Expression; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D035683:MicroRNAs / Q000008:administration & dosage*; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D008055:Lipids; D035683:MicroRNAs