title: Long and short (timeframe) of endoplasmic reticulum stress-induced cell death.
abstract: A number of age-dependent degenerative diseases are caused by chronic endoplasmic reticulum (ER) stress in vital cells. In many cases, the afflicted cells suffer from ER stress since birth, but the death of irreplaceable cells occurs only late in life. Although our understanding of ER stress-induced cell death has advanced significantly, most of the known mechanisms involve pathways that signal within hours, and it remains unclear how these pathways regulate cell death that occurs only decades later. Here, I highlight the conceptual issues and suggest ways to make sense of the age-related effect of ER stress-induced cell death in degenerative diseases.
authors.affiliation: Department of Cell Biology, New York University School of Medicine, NY, USA. hyungdon.ryoo@nyumc.org.
authors.forename: Hyung Don
authors.initials: HD
authors.lastname: Ryoo
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D020169:Caspases / Q000378:metabolism; D016923:Cell Death / Q000502:physiology*; D016922:Cellular Senescence / Q000502:physiology; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D013997:Time Factors; D056811:Unfolded Protein Response
chemical_list: D020169:Caspases
keywords: 
  PERK
  ; ER stress; IRE1; apoptosis; caspase; cell death; degenerative disease; unfolded protein response