title: Scedosporium apiospermum and S. prolificans mixed disseminated infection in a lung transplant recipient: An unusual case of long-term survival with combined systemic and local antifungal therapy in intensive care unit.
abstract: Infections due Scedosporium spp. in lung transplant recipients are associated with disseminated disease with high mortality rates. The adjunctive local antifungal therapy may be a useful option when systemic treatment is insufficient and/or surgery is not feasible. We present a case of mixed disseminated infection due Scedosporium apiospermum and S. prolificans in a lung transplant recipient. Combined local and systemic antifungal therapy provided an unusual long-term survival in the intensive care unit.
authors.affiliation: Intensive Care Unit, Hospital Universitario Puerta de Hierro Majadahonda, Spain.
authors.forename: Bárbara
authors.initials: B
authors.lastname: Balandin
authors.affiliation: Department of Pneumology and Lung Transplant Unit, Hospital Universitario Puerta de Hierro Majadahonda, Spain.
authors.forename: Miriam
authors.initials: M
authors.lastname: Aguilar
authors.affiliation: Department of Microbiology, Hospital Universitario Puerta de Hierro Majadahonda, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Sánchez
authors.affiliation: Department of Mycology, Instituto de Salud Carlos III, Majadahonda, Spain.
authors.forename: Araceli
authors.initials: A
authors.lastname: Monzón
authors.affiliation: Department of Radiology, Hospital Universitario Puerta de Hierro Majadahonda, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Rivera
authors.affiliation: Department of Pathology, Hospital Universitario Puerta de Hierro Majadahonda, Spain.
authors.forename: Clara
authors.initials: C
authors.lastname: Salas
authors.affiliation: Intensive Care Unit, Hospital Universitario Puerta de Hierro Majadahonda, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Valdivia
authors.affiliation: Intensive Care Unit, Hospital Universitario Puerta de Hierro Majadahonda, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Alcántara
authors.affiliation: Intensive Care Unit, Hospital Universitario Puerta de Hierro Majadahonda, Spain.
authors.forename: Aris
authors.initials: A
authors.lastname: Pérez
authors.affiliation: Department of Pneumology and Lung Transplant Unit, Hospital Universitario Puerta de Hierro Majadahonda, Spain.
authors.forename: Piedad
authors.initials: P
authors.lastname: Ussetti
keywords: Disseminated infection; Local antifungal therapy; Long-term survival; Lung transplant recipient; Scedosporium spp; Synergy test