title: rs965513 polymorphism as a common risk marker is associated with papillary thyroid cancer.
abstract: Papillary thyroid cancer (PTC) is the most common type of thyroid cancer. With the rapid development of genome-wide association studies (GWAS), many genome variants associated with susceptibility to PTC have been identified, including the single nucleotide polymorphism rs965513 (9q22.33) near FOXE1. To evaluate the association between rs965513 and PTC in different ethnicities and countries, we conducted a meta-analysis using relatively large-scale samples from 23 studies (N = 163,136; 20,736 cases and 142,400 controls) by searching the PubMed and Google Scholar databases. Significant heterogeneity caused by different populations among the selected studies was observed. The A allele of rs965513 polymorphism was shown to be highly associated with risk of thyroid cancer, with odds ratios of 1.58 (95% CI 1.32-1.90) in all populations, 1.65 (95% CI 1.31-2.07)) in Caucasian populations and 1.49 in Asian populations. Compared to the dominant and recessive models, we observed the highest odds ratio (OR = 2.80, 95% CI 2.12-3.69) in the homozygous model. These results revealed that the rs965513 polymorphism is a risk factor for thyroid cancer.
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
authors.forename: Dehui
authors.initials: D
authors.lastname: Yan
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Ji
authors.affiliation: Department of Endemic Disease, the Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Endemic Disease, the Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China.
authors.forename: Meijun
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Endemic Disease, the Second Affiliated Hospital, Harbin Medical University, Harbin, 150086, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Qiao
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
authors.forename: Shaojun
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D014408:Biomarkers, Tumor / Q000235:genetics*; D002291:Carcinoma, Papillary / Q000453:epidemiology / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D051858:Forkhead Transcription Factors / Q000235:genetics*; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; C106894:FOXE1 protein, human; D051858:Forkhead Transcription Factors
keywords: FOXE1; genome-wide association studies; meta-analysis; rs965513; thyroid cancer