title: Apoptosis-Mediated Chemoprevention by Different Ratios of Fish Oil in Experimental Colon Carcinogenesis.
abstract: Apoptosis plays an important role in prevention of colon cancer. In the present study, different ratios of fish oil and corn oil increased Fas expression in both phases and a decrease in FasL expression only in post initiation phase. Treatment with fish oil activated the intrinsic apoptotic pathway by increasing Bax expression and Cyt c release and decreasing Bcl-2 levels in both phases. This suggests that intrinsic pathway is upregulated by fish oil; however, Fas-FasL activity may be involved in inhibition of reversal of immune surveillance in tumor cells.
authors.affiliation: a Department of Biochemistry , Panjab University , Chandigarh , India.
authors.forename: Gayatri
authors.initials: G
authors.lastname: Sharma
authors.affiliation: a Department of Biochemistry , Panjab University , Chandigarh , India.
authors.forename: Isha
authors.initials: I
authors.lastname: Rani
authors.affiliation: a Department of Biochemistry , Panjab University , Chandigarh , India.
authors.forename: Archana
authors.initials: A
authors.lastname: Bhatnagar
authors.affiliation: a Department of Biochemistry , Panjab University , Chandigarh , India.
authors.forename: Navneet
authors.initials: N
authors.lastname: Agnihotri
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D015415:Biomarkers; D063646:Carcinogenesis / Q000187:drug effects*; D018890:Chemoprevention; D003110:Colonic Neoplasms / Q000209:etiology* / Q000473:pathology* / Q000517:prevention & control; D003314:Corn Oil / Q000008:administration & dosage / Q000494:pharmacology; D004195:Disease Models, Animal; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology*; D015870:Gene Expression; D006801:Humans; D008297:Male; D051381:Rats
chemical_list: D016588:Anticarcinogenic Agents; D015415:Biomarkers; D005395:Fish Oils; D003314:Corn Oil
keywords: Cancer; Fish oil (FO); Polyunsaturated fatty acids (PUFA); n-3 Fatty acids