title: Influence of anatomical dominance and hypertension on coronary conduit arterial and microcirculatory flow patterns: a multiscale modeling study.
abstract: Coronary hemodynamics are known to be affected by intravascular and extravascular factors that vary regionally and transmurally between the perfusion territories of left and right coronary arteries. However, despite clinical evidence that left coronary arterial dominance portends greater cardiovascular risk, relatively little is known about the effects of left or right dominance on regional conduit arterial and microcirculatory blood flow patterns, particularly in the presence of systemic or pulmonary hypertension. We addressed this issue using a multiscale numerical model of the human coronary circulation situated in a closed-loop cardiovascular model. The coronary model represented left or right dominant anatomies and accounted for transmural and regional differences in vascular properties and extravascular compression. Regional coronary flow dynamics of the two anatomical variants were compared under normotensive conditions, raised systemic or pulmonary pressures with maintained flow demand, and after accounting for adaptations known to occur in acute and chronic hypertensive states. Key findings were that 1) right coronary arterial flow patterns were strongly influenced by dominance and systemic/pulmonary hypertension; 2) dominance had minor effects on left coronary arterial and all microvascular flow patterns (aside from mean circumflex flow); 3) although systemic hypertension favorably increased perfusion pressure, this benefit varied regionally and transmurally and was offset by increased left ventricular and septal flow demands; and 4) pulmonary hypertension had a substantial negative effect on right ventricular and septal flows, which was exacerbated by greater metabolic demands. These findings highlight the importance of interactions between coronary arterial dominance and hypertension in modulating coronary hemodynamics.
authors.affiliation: Heart Research, Clinical Sciences, Murdoch Childrens Research Institute, Parkville, Victoria, Australia; and Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia jonathan.mynard@mcri.edu.au.
authors.forename: Jonathan P
authors.identifier: 0000-0002-5692-2106
authors.initials: JP
authors.lastname: Mynard
authors.affiliation: Heart Research, Clinical Sciences, Murdoch Childrens Research Institute, Parkville, Victoria, Australia; and Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Smolich
mesh_terms: D000222:Adaptation, Physiological; D001783:Blood Flow Velocity; D003198:Computer Simulation; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D008833:Microcirculation; D008955:Models, Cardiovascular; D009716:Numerical Analysis, Computer-Assisted; D012039:Regional Blood Flow; D013997:Time Factors; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right
keywords: left coronary artery; pulmonary hypertension; right coronary artery; systemic hypertension