title: Genetic polymorphism of HLA-DQ confers susceptibility to hepatitis B virus-related hepatocellular carcinoma: a case-control study in Han population in China.
abstract: Several recent genome-wide studies showed that the genetic polymorphisms in the HLA-DQ region (rs9275572 and rs2856718) were related to chronic hepatitis B virus (HBV) infection and chronic hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC). We analyzed the two single-nucleotide polymorphisms for major HBV outcomes in Han Chinese. A total of 1291 samples were involved and peripheral blood samples were collected in this study. Matrix-assisted laser desorption/ionization time of flight mass spectrometry were used to genotype the single-nucleotide polymorphisms in the HLA-DQ region. Our study indicated the clear relationship between the HLA-DQ rs9275572 and HBV-related HCC after control for the effects of sex, drinking, and smoking. Health subjects with the HLA-DQ rs9275572 GA genotype would have a 0.641 (95 % CI 0.416, 0.985; P = 0.043) times lower odds of having HCC, and those with the AA genotype would have a 0.256 (95 % CI 0.106, 0.618; P = 0.002) times lower odds of having HCC, whereas the values of the other covariates were fixed. Whereas there was no significant difference found for the HLA-DQ rs2856718 AG and GG genotype. Our study suggested that HLA-DQ loci (rs9275572) were associated with HBV-related HCC as a protective factor in Han Chinese.
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shi Jiazhuang, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shi Jiazhuang, China.
authors.forename: Wenxuan
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shi Jiazhuang, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shi Jiazhuang, China.
authors.forename: Longmei
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shi Jiazhuang, China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shi Jiazhuang, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Yan
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shi Jiazhuang, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shi Jiazhuang, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shi Jiazhuang, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shi Jiazhuang, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Shi Jiazhuang, China. 13493139@qq.com.
authors.forename: Dianwu
authors.initials: D
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D006683:HLA-DQ Antigens
keywords: HLA-DQ; Hepatitis B virus; Hepatocellular carcinoma; Polymorphisms