title: Effect of high-fat diets on mood and learning performance in adolescent mice.
abstract: Recent studies point to dietary factors as important effectors in the brain and epidemiological studies suggest a direct relationship between mood and anxiety disorders, cognitive impairment and obesity. Nevertheless the link between the consumption of high-fat diets (HFD) and emotional disorders still remains unclear. This issue is of particular interest during adolescence, which is an important period for shaping learning and memory acquisition that can be particularly sensitive to the detrimental effects of HFD. Otherwise, major depressive disorder and anxiety crisis often emerge in adolescence. In the current study we have characterized in adolescent mice i) the onset of HFD-induced memory impairment using the novel location recognition (NLR) paradigm, and ii) the effect of HFD on depression- and anxiety-related behaviors by using the forced swimming and the elevated plus maze tests, respectively. Here we report that memory impairments induced by HFD were already perceptible after 4-weeks HFD whereas HFD induced already antidepressant-like effects after 48-h, that remained after long-term treatment (8 weeks). No effects in anxiety were found. These data indicate that the antidepressant-like effect of HFD is independent of memory deficits as it was already present after 48-h HFD, while no effects in memory were still observed at this time.
authors.affiliation: Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU-San Pablo, Campus de Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain.
authors.forename: Danila
authors.initials: D
authors.lastname: Del Rio
authors.affiliation: Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU-San Pablo, Campus de Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain.
authors.forename: Lidia
authors.initials: L
authors.lastname: Morales
authors.affiliation: Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU-San Pablo, Campus de Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain.
authors.forename: Mariano
authors.initials: M
authors.lastname: Ruiz-Gayo
authors.affiliation: Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU-San Pablo, Campus de Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain. Electronic address: nolmo@ceu.es.
authors.forename: Nuria
authors.initials: N
authors.lastname: Del Olmo
mesh_terms: D000339:Affect / Q000187:drug effects; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D003866:Depressive Disorder / Q000188:drug therapy / Q000209:etiology; D003975:Diazepam / Q000494:pharmacology; D059305:Diet, High-Fat / Q000009:adverse effects*; D005106:Exploratory Behavior / Q000187:drug effects; D007858:Learning / Q000187:drug effects; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy / Q000209:etiology; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D011897:Random Allocation; D021641:Recognition, Psychology / Q000187:drug effects; D065852:Spatial Memory / Q000187:drug effects; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D003975:Diazepam
keywords: Depression; Diazepam; Fluoxetine; High-fat diet; Learning; Memory