title: [Potentially toxic antibiotics concentrations after administration using impregnated dressing in a severe burned patient: A case report].
abstract: Severe burned patients present high risk of skins infections, frequently due to Pseudomonas aeruginosa. Impregnated dressings with amikacin or colistin could be a good alternative to obtain effective concentration directly at the infected site. Therapeutic drug monitoring for these antibiotics is currently recommended after an intravenous administration to obtain effective and non-toxic plasmatic concentrations. However, data are lacking about systemic exposition and risk of toxicity after an administration with impregnated dressings. We report the case of a severe burned patient with cutaneous infection treated with amikacin and colistin impregnated dressings, for which plasmatic pharmacokinetic profiles were performed.
authors.affiliation: Service de pharmacologie clinique et pharmacovigilance, laboratoire de pharmacologie clinique, hôpital de la Timone, CHU de la Timone, AP-HM, 13385 Marseille, France. Electronic address: julien.dupouey@ap-hm.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Dupouey
authors.affiliation: Service d'anesthésie et de réanimation, centre des brûlés interrégional Méditerranée, hôpital de la Conception, AP-HM, 13005 Marseille, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Wiramus
authors.affiliation: Service d'anesthésie et de réanimation, centre des brûlés interrégional Méditerranée, hôpital de la Conception, AP-HM, 13005 Marseille, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Albanese
authors.affiliation: Service de pharmacologie clinique et pharmacovigilance, laboratoire de pharmacologie clinique, hôpital de la Timone, CHU de la Timone, AP-HM, 13385 Marseille, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Guilhaumou
authors.affiliation: Service de pharmacologie clinique et pharmacovigilance, laboratoire de pharmacologie clinique, hôpital de la Timone, CHU de la Timone, AP-HM, 13385 Marseille, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Blin
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects* / Q000097:blood; D001458:Bandages; D002056:Burns / Q000150:complications*; D004305:Dose-Response Relationship, Drug; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D012772:Shock, Septic / Q000209:etiology; D014946:Wound Infection / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Aminoglycosid; Aminoglycosides; Brûlure; Burns; Colimycine; Colistin; Cutaneus infection; Infection cutanée; Suivi thérapeutique pharmacologique; Therapeutic drug monitoring