title: Endothelial dysfunction in human essential hypertension.
abstract: Although the endothelium has a number of important functions, the term endothelial dysfunction is commonly used to describe impairment in its vasodilatory capacity. It is increasingly recognized that this is related to hypertension, although whether it predates essential hypertension or is a consequence of it is still unknown. In this review, we explore the mechanisms of endothelial dysfunction in essential hypertension, its prognostic significance and methods of pharmacological reversal.
authors.affiliation: aInstitute of Cardiovascular and Medical Sciences, University of Glasgow bRenal Unit, Queen Elizabeth University Hospital, Glasgow, UK.
authors.forename: Ify
authors.initials: I
authors.lastname: Mordi
authors.forename: Natalie
authors.initials: N
authors.lastname: Mordi
authors.forename: Christian
authors.initials: C
authors.lastname: Delles
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Tzemos
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D065128:Endothelin Receptor Antagonists / Q000627:therapeutic use; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D000075222:Essential Hypertension; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D012084:Renin-Angiotensin System / Q000187:drug effects; D014664:Vasodilation
chemical_list: D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D004232:Diuretics; D065128:Endothelin Receptor Antagonists