title: Relatively speaking.
abstract: Protein X is a signalling molecule that stimulates apoptosis. Treatment of cells with Protein X results in five times higher levels of cell death than those seen in untreated cells (wild type), as measured by Caspase-positive cells. Based on previous work, the authors identify Protein Y as the putative receptor for Protein X and here try to test whether this is indeed the case. They claim that in a geneY mutant, where no receptor is expressed, treatment with Protein X no longer results in increased cell death, supporting the hypothesis that Protein Y is the receptor for signalling molecule X.
authors.affiliation: BMC Biology, BioMed Central, 236 Gray's Inn Road, London, WC1X 8HB, UK. BMCBiologyEditorial@biomedcentral.com.
authors.forename: Graham
authors.initials: G
authors.lastname: Bell
mesh_terms: D017209:Apoptosis; D020169:Caspases
chemical_list: D020169:Caspases