title: Non-invasive monitoring of pulmonary artery pressure from timing information by EIT: experimental evaluation during induced hypoxia.
abstract: Monitoring of pulmonary artery pressure (PAP) in pulmonary hypertensive patients is currently limited to invasive solutions. We investigate a novel non-invasive approach for continuous monitoring of PAP, based on electrical impedance tomography (EIT), a safe, low-cost and non-invasive imaging technology. EIT recordings were performed in three healthy subjects undergoing hypoxia-induced PAP variations. The pulmonary pulse arrival time (PAT), a timing parameter physiologically linked to the PAP, was automatically calculated from the EIT signals. Values were compared to systolic PAP values from Doppler echocardiography, and yielded strong correlation scores ([Formula: see text]) for all three subjects. Results suggest the feasibility of non-invasive, unsupervised monitoring of PAP.
authors.affiliation: Systems Division, Centre Suisse d'Electronique et de Microtechnique (CSEM), Neuchâtel, Switzerland. Signal Processing Laboratory (LTS5), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
authors.forename: Martin
authors.initials: M
authors.lastname: Proença
authors.forename: Fabian
authors.initials: F
authors.lastname: Braun
authors.forename: Josep
authors.initials: J
authors.lastname: Solà
authors.forename: Andy
authors.initials: A
authors.lastname: Adler
authors.forename: Mathieu
authors.initials: M
authors.lastname: Lemay
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Thiran
authors.forename: Stefano F
authors.initials: SF
authors.lastname: Rimoldi
mesh_terms: D000328:Adult; D000465:Algorithms; D000531:Altitude; D003935:Diagnostic Techniques, Cardiovascular; D017097:Electric Impedance; D005240:Feasibility Studies; D006801:Humans; D000860:Hypoxia / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D010363:Pattern Recognition, Automated / Q000379:methods; D011651:Pulmonary Artery / Q000000981:diagnostic imaging* / Q000502:physiology* / Q000503:physiopathology; D011674:Pulse; D016683:Supine Position; D014054:Tomography / Q000379:methods*