title: Treponema pallidum Strain Types and Association with Macrolide Resistance in Sydney, Australia: New TP0548 Gene Types Identified.
abstract: Strain typing of Treponema pallidum, using the three-target enhanced classification scheme, was performed with 191 samples obtained between 2004 and 2011 in Sydney, Australia. The most common strain type was 14d/g (92/191 samples [48%]). Two new TP0548 gene types were detected (m and n). Strain type was associated with macrolide resistance and possible acquisition outside Australia.
authors.affiliation: Kirketon Road Centre, South East Sydney Local Health District, Sydney, NSW, Australia The Kirby Institute, UNSW Australia, Sydney, NSW, Australia phillip.read@sesiahs.health.nsw.gov.au.
authors.forename: Phillip
authors.initials: P
authors.lastname: Read
authors.affiliation: Centre for Infectious Diseases and Microbiology-Public Health, Institute for Clinical Pathology and Medical Research, University of Sydney Western Clinical School, Westmead Hospital, Sydney, NSW, Australia.
authors.forename: Kaitlin A
authors.initials: KA
authors.lastname: Tagg
authors.affiliation: Centre for Infectious Diseases and Microbiology-Public Health, Institute for Clinical Pathology and Medical Research, University of Sydney Western Clinical School, Westmead Hospital, Sydney, NSW, Australia.
authors.forename: Neisha
authors.initials: N
authors.lastname: Jeoffreys
authors.affiliation: The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Guy
authors.affiliation: Centre for Infectious Diseases and Microbiology-Public Health, Institute for Clinical Pathology and Medical Research, University of Sydney Western Clinical School, Westmead Hospital, Sydney, NSW, Australia.
authors.forename: Gwendolyn L
authors.initials: GL
authors.lastname: Gilbert
authors.affiliation: The Kirby Institute, UNSW Australia, Sydney, NSW, Australia Sydney Sexual Health Centre, Sydney Hospital, Sydney, NSW, Australia.
authors.forename: Basil
authors.initials: B
authors.lastname: Donovan
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001315:Australia; D024881:Drug Resistance, Bacterial; D005260:Female; D005838:Genotype; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D058889:Molecular Typing; D013587:Syphilis / Q000382:microbiology*; D014210:Treponema pallidum / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides