title: Prevalence and risk factors for venous thromboembolic complications in the Swiss Inflammatory Bowel Disease Cohort.
abstract: OBJECTIVE
  Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is associated with the occurrence of venous thromboembolism (VTE) such as deep vein thrombosis (DVT) and pulmonary embolism (PE). We aimed to assess the prevalence and associated risk factors for VTE in a large national cohort of IBD patients.
  
  
  METHODS
  Data from patients of the Swiss IBD Cohort Study (SIBDCS) enrolled between 2006 and 2013 were analyzed.
  
  
  RESULTS
  A total of 2284 IBD patients were analyzed of which 1324 suffered from CD and 960 from UC. VTE prevalence was 3.9% (90/2284) overall and 3.4% (45/1324) in CD patients (whereof 2.4% suffered from DVT and 1.5% from PE) and 4.7% (45/960) in UC patients (whereof 3.2% suffered from DVT and 2.4% from PE). Median disease duration in CD patients with VTE was 12 years [IQR 8-23] compared to eight years [3-16] in CD patients without VTE (p = 0.001). Disease duration in UC patients with VTE was seven years [4-18] compared to six years [2-13] in UC patients without VTE (p = 0.051). Age at CD diagnosis ≥40 years (OR 1.851, p = 0.073) and disease duration >10 years (OR 1.771, p = 0.088) showed a trend to be associated with VTE. In UC patients, IBD-related surgery (OR 3.396, p = 0.004) and pancolitis (OR 1.927, p = 0.050) were significantly associated with VTE.
  
  
  CONCLUSIONS
  VTE are prevalent in CD and UC patients. Pancolitis and UC-related surgery are significantly associated with VTE in UC patients.
authors.affiliation: a Division of Angiology , Lausanne University Hospital , Lausanne , Switzerland ;
authors.forename: Adriano
authors.initials: A
authors.lastname: Alatri
authors.affiliation: b Division of Gastroenterology and Hepatology , Lausanne University Hospital , Lausanne , Switzerland ;
authors.forename: Alain
authors.initials: A
authors.lastname: Schoepfer
authors.affiliation: c Institute of Social and Preventive Medicine, University of Lausanne , Lausanne , Switzerland ;
authors.forename: Nicolas
authors.initials: N
authors.lastname: Fournier
authors.affiliation: a Division of Angiology , Lausanne University Hospital , Lausanne , Switzerland ;
authors.forename: Rolf Peter
authors.initials: RP
authors.lastname: Engelberger
authors.affiliation: d Institute of Social and Preventive Medicine, University of Bern , Bern , Switzerland ;
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Safroneeva
authors.affiliation: e Division of Gastroenterology and Hepatology , Stadtspital Triemli , Zurich , Switzerland ;|f Division of Gastroenterology and Hepatology , University Hospital , Zurich , Switzerland.
authors.forename: Stephan
authors.initials: S
authors.lastname: Vavricka
authors.affiliation: f Division of Gastroenterology and Hepatology , University Hospital , Zurich , Switzerland.
authors.forename: Luc
authors.initials: L
authors.lastname: Biedermann
authors.affiliation: a Division of Angiology , Lausanne University Hospital , Lausanne , Switzerland ;
authors.forename: Luca
authors.initials: L
authors.lastname: Calanca
authors.affiliation: a Division of Angiology , Lausanne University Hospital , Lausanne , Switzerland ;
authors.forename: Lucia
authors.initials: L
authors.lastname: Mazzolai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003092:Colitis / Q000601:surgery*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000601:surgery; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000453:epidemiology; D015995:Prevalence; D011655:Pulmonary Embolism / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D013557:Switzerland; D020246:Venous Thrombosis / Q000453:epidemiology*; D055815:Young Adult
keywords: Crohn's disease; thromboembolic complications; ulcerative colitis; venous thromboembolism