title: Tandem Catalysis Utilizing Olefin Metathesis Reactions.
abstract: Since olefin metathesis transformation has become a favored synthetic tool in organic synthesis, more and more distinct non-metathetical reactions of alkylidene ruthenium complexes have been developed. Depending on the conditions applied, the same olefin metathesis catalysts can efficiently promote isomerization reactions, hydrogenation of C=C double bonds, oxidation reactions, and many others. Importantly, these transformations can be carried out in tandem with olefin metathesis reactions. Through addition of one portion of a catalyst, a tandem process provides structurally advanced products from relatively simple substrates without the need for isolation of the intermediates. These aspects not only make tandem catalysis very attractive from a practical point of view, but also open new avenues in (retro)synthetic planning. However, in the literature, the term "tandem process" is sometimes used improperly to describe other types of multi-reaction sequences. In this Concept, a number of examples of tandem catalysis involving olefin metathesis are discussed with an emphasis on their synthetic value.
authors.affiliation: Institute of Organic Chemistry Polish Academy of Sciences, Kasprzaka 44/52, 01-224, Warsaw, Poland. grzesiek.zielinski88@gmail.com.
authors.forename: Grzegorz K
authors.initials: GK
authors.lastname: Zieliński
authors.affiliation: Institute of Organic Chemistry Polish Academy of Sciences, Kasprzaka 44/52, 01-224, Warsaw, Poland. karol.grela@gmail.com, karol.grela@gmail.com.|Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Żwirki i Wigury 101, 02-089, Warsaw, Poland. karol.grela@gmail.com, karol.grela@gmail.com.
authors.forename: Karol
authors.initials: K
authors.lastname: Grela
keywords: homogeneous catalysis; natural products; olefin metathesis; ruthenium; tandem processes