title: Acute-Phase Inflammatory Response to Single-Bout HIIT and Endurance Training: A Comparative Study.
abstract: OBJECTIVE
  This study compared acute and late effect of single-bout endurance training (ET) and high-intensity interval training (HIIT) on the plasma levels of four inflammatory cytokines and C-reactive protein and insulin-like growth factor 1.
  
  
  METHODS
  Cohort study with repeated-measures design.
  
  
  METHODS
  Seven healthy untrained volunteers completed a single bout of ET and HIIT on a cycle ergometer. ET and HIIT sessions were held in random order and at least 7 days apart. Blood was drawn before the interventions and 30 min and 2 days after the training sessions. Plasma samples were analyzed with ELISA for the interleukins (IL), IL-1β, IL-6, and IL-10, monocyte chemoattractant protein-1 (MCP-1), insulin growth factor 1 (IGF-1), and C-reactive protein (CRP). Statistical analysis was with Wilcoxon signed-rank tests.
  
  
  RESULTS
  ET led to both a significant acute and long-term inflammatory response with a significant decrease at 30 minutes after exercise in the IL-6/IL-10 ratio (-20%; p = 0.047) and a decrease of MCP-1 (-17.9%; p = 0.03).
  
  
  CONCLUSIONS
  This study demonstrates that ET affects the inflammatory response more adversely at 30 minutes after exercise compared to HIIT. However, this is compensated by a significant decrease in MCP-1 at two days associated with a reduced risk of atherosclerosis.
authors.affiliation: Department of Biotechnology, Institute for Biochemistry and Biotechnology, Technical University Braunschweig, 38126 Braunschweig, Germany; School of Community Health, Charles Sturt University, Albury, NSW 2640, Australia.
authors.forename: Felix
authors.initials: F
authors.lastname: Kaspar
authors.affiliation: School of Community Health, Charles Sturt University, Albury, NSW 2640, Australia; Australian School of Advanced Medicine, Macquarie University, Sydney, NSW 2109, Australia.
authors.forename: Herbert F
authors.initials: HF
authors.lastname: Jelinek
authors.affiliation: School of Community Health, Charles Sturt University, Albury, NSW 2640, Australia.
authors.forename: Steven
authors.initials: S
authors.lastname: Perkins
authors.affiliation: School of Medicine, University of Tasmania, Hobart, TAS 7001, Australia.
authors.forename: Hayder A
authors.initials: HA
authors.lastname: Al-Aubaidy
authors.affiliation: School of Community Health, Charles Sturt University, Albury, NSW 2640, Australia.
authors.forename: Bev
authors.initials: B
authors.lastname: deJong
authors.affiliation: School of Community Health, Charles Sturt University, Albury, NSW 2640, Australia.
authors.forename: Eugene
authors.initials: E
authors.lastname: Butkowski
mesh_terms: D000210:Acute-Phase Reaction / Q000276:immunology / Q000378:metabolism; D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005260:Female; D000072696:High-Intensity Interval Training; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism*; D016753:Interleukin-10 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D055815:Young Adult
chemical_list: D015850:Interleukin-6; D016753:Interleukin-10; D002097:C-Reactive Protein