title: Transporter and its engineering for secondary metabolites.
abstract: Secondary metabolites possess a lot of biological activities, and to achieve their functions, transmembrane transportation is crucial. Elucidation of their transport mechanisms in the cell is critical for discovering ways to improve the production. Here, we have summarized the recent progresses for representative secondary metabolite transporters and also the strategies for uncovering the transporter systems in plants and microbes. We have also discussed the transporter engineering strategies being utilized for improving the heterologous natural product production, which exhibits promising future under the guide of synthetic biology.
authors.affiliation: Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200032, China.
authors.forename: Huajun
authors.initials: H
authors.lastname: Lv
authors.affiliation: Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200032, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200032, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200032, China.
authors.forename: Sanjog
authors.initials: S
authors.lastname: Garyali
authors.affiliation: Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200032, China. yongwang@sibs.ac.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
mesh_terms: D001230:Aspergillus / Q000378:metabolism; D001688:Biological Products / Q000378:metabolism; D001692:Biological Transport; D004926:Escherichia coli / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism; D060847:Metabolic Engineering; D064209:Phytochemicals / Q000096:biosynthesis; D010944:Plants / Q000737:chemistry; D015202:Protein Engineering; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D064210:Secondary Metabolism / Q000502:physiology*; D048372:Streptomyces coelicolor / Q000378:metabolism; D058615:Synthetic Biology
chemical_list: D001688:Biological Products; D026901:Membrane Transport Proteins; D064209:Phytochemicals
keywords: Engineering; Heterologous expression; Secondary metabolites; Synthetic biology; Transporter