title: Renal impairment in multiple myeloma: A single center experience.
abstract: To determine the features of the different forms of kidney diseases associated with multiple myeloma (MM), we retrospectively studied 144 patients with kidney injury and MM at our institute from 1974 to 2014. The mean age of the patients was 60.1 years and the male:female ratio was 1.25. Renal disease was concomitant with the discovery of MM in 92% of cases. The mean follow-up of our patients was 2.1 years. Initial renal insufficiency was found in 131 (91%) patients. Cast nephropathy of the distal tubule was found in 110 (26%) patients, renal amyloidosis in 16 (11.1%), and light chain deposition disease in five (3.47%). Twelve (8.3%) patients had chronic glomerular nephropathy. Twenty-six patients reached end-stage renal failure within 13.4 months. Renal survival was 30.45 months. Predictive factors for improvement of renal function undergoing chemotherapy included serum creatinine <250 µmol/L, proteinuria <1 g/24 h, and the non-use of renal replacement therapy. Multiple pathogenic mechanisms can contribute to kidney injury in myeloma patients. Novel myeloma agents have shown considerable promise in reversing renal failure in some patients and improving outcomes.
authors.affiliation: Department of Medicine A (M8); Laboratory of Research in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital; Faculty of Medicine, University of Tunis El Manar, Tunisia.
authors.forename: Imen
authors.initials: I
authors.lastname: Gorsane
authors.affiliation: Department of Medicine A (M8), Charles Nicolle Hospital; Faculty of Medicine, University of Tunis El Manar; Laboratory of Kidney Pathology (LR00SP01), Charles Nicolle Hospital, Tunis, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Barbouch
authors.affiliation: Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Mayara
authors.affiliation: Department of Medicine A (M8), Charles Nicolle Hospital; Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.
authors.forename: K Ben
authors.initials: KB
authors.lastname: Abdelghani
authors.affiliation: Department of Medicine A (M8), Charles Nicolle Hospital; Faculty of Medicine, University of Tunis El Manar; Laboratory of Kidney Pathology (LR00SP01), Charles Nicolle Hospital, Tunis, Tunisia.
authors.forename: R
authors.initials: R
authors.lastname: Goucha
authors.affiliation: Department of Medicine A (M8), Charles Nicolle Hospital; Faculty of Medicine, University of Tunis El Manar; Laboratory of Kidney Pathology (LR00SP01), Charles Nicolle Hospital, Tunis, Tunisia.
authors.forename: F Ben
authors.initials: FB
authors.lastname: Hamida
authors.affiliation: Department of Medicine A (M8), Charles Nicolle Hospital; Faculty of Medicine, University of Tunis El Manar; Laboratory of Kidney Pathology (LR00SP01), Charles Nicolle Hospital, Tunis, Tunisia.
authors.forename: H
authors.initials: H
authors.lastname: Hedri
authors.affiliation: Department of Medicine A (M8); Laboratory of Research in Immunology of Renal Transplantation and Immunopathology (LR03SP01), Charles Nicolle Hospital; Faculty of Medicine, University of Tunis El Manar, Tunisia.
authors.forename: T Ben
authors.initials: TB
authors.lastname: Abdallah
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000453:epidemiology*; D051437:Renal Insufficiency / Q000150:complications* / Q000453:epidemiology*; D012189:Retrospective Studies