title: Report of the Cent Gardes HIV Vaccines Conference. Part 1: The antibody response; Fondation Mérieux Conference Center, Veyrier-du-Lac, France, 25-27 October 2015.
abstract: The 2015 Cent Gardes Conference on HIV vaccines took place on October 25-27 at the Merieux Foundation Conference Center in Veyrier du Lac, near Annecy, France. The meeting reviewed progress in the development of HIV vaccines and identified new directions of future research. The field has advanced incrementally over the past year but major progress will require additional information from new clinical trials. In this article, we review the presentations on humoral immune responses to HIV, and highlight the difficulty of eliciting broadly neutralizing antibodies by vaccination. Advances in cellular immunity for HIV prevention will be reviewed separately, in a following article.
authors.affiliation: French National Academy of Medicine, 16 rue Bonaparte, 75006 Paris, France. Electronic address: Marc.girard36@wanadoo.fr.
authors.forename: Marc P
authors.initials: MP
authors.lastname: Girard
authors.affiliation: Atomic Energy Commission (CEA) INSERM, Paris Sud University, UMR 1184, IDMIT Infrastructures, 92265 Fontenay aux Roses Cedex, France. Electronic address: Roger.le-grand@cea.fr.
authors.forename: Roger
authors.initials: R
authors.lastname: Le-Grand
authors.affiliation: Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon, France. Electronic address: Valentina.picot@fondation-merieux.org.
authors.forename: Valentina
authors.initials: V
authors.lastname: Picot
authors.affiliation: Fondation Mérieux, 17 rue Bourgelat, 69002 Lyon, France. Electronic address: Christophe.longuet@fondation-merieux.org.
authors.forename: Christophe
authors.initials: C
authors.lastname: Longuet
authors.affiliation: Sanofi, 640 Memorial Drive, Cambridge, MA 031 39, USA. Electronic address: Gary.nabel@sanofi.com.
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Nabel
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology; D000917:Antibody Formation; D003226:Congresses as Topic; D005602:France; D015483:HIV Antibodies / Q000276:immunology*; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D056724:Immunity, Humoral; D007116:Immunization, Passive
chemical_list: D016915:AIDS Vaccines; D057134:Antibodies, Neutralizing; D015483:HIV Antibodies
keywords: ADCC; B cell lineage; HIV; Mucosal immunity; Neutralizing antibodies; Passive immunization