title: Shigella Antimicrobial Drug Resistance Mechanisms, 2004-2014.
abstract: To determine antimicrobial drug resistance mechanisms of Shigella spp., we analyzed 344 isolates collected in Switzerland during 2004-2014. Overall, 78.5% of isolates were multidrug resistant; 10.5% were ciprofloxacin resistant; and 2% harbored mph(A), a plasmid-mediated gene that confers reduced susceptibility to azithromycin, a last-resort antimicrobial agent for shigellosis.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Nüesch-Inderbinen
authors.forename: Nicole
authors.initials: N
authors.lastname: Heini
authors.forename: Katrin
authors.initials: K
authors.lastname: Zurfluh
authors.forename: Denise
authors.initials: D
authors.lastname: Althaus
authors.forename: Herbert
authors.initials: H
authors.lastname: Hächler
authors.forename: Roger
authors.initials: R
authors.lastname: Stephan
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D004405:Dysentery, Bacillary / Q000188:drug therapy / Q000453:epidemiology* / Q000266:history / Q000382:microbiology*; D005798:Genes, Bacterial; D049674:History, 21st Century; D006801:Humans; D008826:Microbial Sensitivity Tests; D012760:Shigella / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D013557:Switzerland / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents
keywords: Shigella; antimicrobial resistance; antimicrobial treatment; azithromycin; bacteria; cephalosporins; ciprofloxacin; multidrug resistance; resistance genes