title: Improved Detection of Helicobacter pylori Infection and Premalignant Gastric Mucosa Using Conventional White Light Source Gastroscopy.
abstract: BACKGROUND
  The gold standard diagnosis of H. pylori related gastritis is evidence of bacteria on histopathological examination of gastric mucosa. Our aim was to study the correlation between gastric mucosal morphology and histopathological severity of H. pylori related gastritis.
  
  
  METHODS
  Division was made on morphological features into:Type 1, showing regular arrangement of red dots; Type 2, showing cleft-like appearance; Type 3, with a mosaic appearance; and Type 4, having a mosaic appearance with focal or diffuse hyperemia.
  
  
  RESULTS
  Types 1 and 2 gastric mucosal morphologies were statistically significant in predicting an H. pylori negative status (137/145, <0.01), while Types 3 and 4 were significant a positive status (139/155, <0.01). The sensitivity, specificity, positive and negative predictive values of Type 3 and 4 morphologies for predicting H. pylori positive were 94.6%, 89.5%, 89.7% and 94.5%, respectively, with a good correlation with inflammation grading (<0.01).
  
  
  CONCLUSIONS
  Our study suggests that gastric mucosal morphology can be reliably identified using conventional white light source gastroscopy with good correlation between findings and inflammation grading.
authors.affiliation: School of Surgery, Institute of Medicine, Suranaree University of Technology, 4Faculty of Public health, Vongchavalitkul University, Nakhon Ratchasima, Thailand E-mail : taweesak.t@sut.ac.th.
authors.forename: Likit
authors.initials: L
authors.lastname: Matrakool
authors.forename: Taweesak
authors.initials: T
authors.lastname: Tongtawee
authors.forename: Theeraya
authors.initials: T
authors.lastname: Bartpho
authors.forename: Chavaboon
authors.initials: C
authors.lastname: Dechsukhum
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Loyd
authors.forename: Soraya J
authors.initials: SJ
authors.lastname: Kaewpitoon
authors.forename: Natthawut
authors.initials: N
authors.lastname: Kaewpitoon
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology*; D005756:Gastritis / Q000175:diagnosis* / Q000382:microbiology; D005773:Gastroscopy / Q000379:methods*; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000382:microbiology; D008027:Light; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000382:microbiology; D011379:Prognosis; D055815:Young Adult