title: The correlation of inflammatory markers and plasma vaspin levels in patients with diabetic nephropathy.
abstract: Vaspin, a recently identified adipokine, is a visceral adipose tissue-derived serine protease inhibitor that may have insulin sensitizing effect on adipose tissue. Herein, we measured vaspin level in patients with different stages of diabetic nephropathy (DNP), and investigated the correlation of the vaspin level with other inflammatory parameters. 106 adult type 2 diabetic patients with no known chronic inflammatory disease were included and grouped according to the stage of DNP: Albuminuria <30 mg/day and estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73m(2) (Group-1); albuminuria 30-300 mg/day and eGFR >60 mL/min/1.73m(2) (Group-2); albuminuria >300 mL/min and eGFR <60 mL/min/1.73m(2) (Group-3). Demographic, clinical and laboratory data were recorded as well as vaspin, high sensitivity C-reactive protein (hsCRP), interleukin (IL)-1 and tumor necrosis factor (TNF)-α levels. There were 38, 35 and 33 patients in Group 1, 2 and 3, respectively. Groups were similar regarding age and gender. Vaspin level did not differ between groups. When all the groups were considered, vaspin was positively correlated with IL-6 level (r = 0.215, p = 0.041). No correlation of vaspin was found with IL-1, TNF-α and hsCRP levels (p = 0.580, r = 0.054; p = 0.463, r = 0.072; p = 0.812, r = 0.025, respectively). Vaspin levels of the patients with GFR ≥60 mL/min/1.73m(2) was less than that of patients with GFR <60 mL/min/1.73m(2) (p = 0.03). Age and IL-6 were found to be the major determinants of vaspin level with linear regression analysis. In patients with DNP, vaspin level does not change within the early stages of DNP; while it is higher in patients with decreased GFR, which may be related with increasing inflammation regardless of the stage of the kidney disease.
authors.affiliation: a Department of Nephrology , Haseki Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Serhat
authors.initials: S
authors.lastname: Karadag
authors.affiliation: b Department of Internal Medicine , Haseki Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Elif
authors.initials: E
authors.lastname: Sakci
authors.affiliation: a Department of Nephrology , Haseki Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Sami
authors.initials: S
authors.lastname: Uzun
authors.affiliation: a Department of Nephrology , Haseki Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Zeki
authors.initials: Z
authors.lastname: Aydin
authors.affiliation: a Department of Nephrology , Haseki Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Egemen
authors.initials: E
authors.lastname: Cebeci
authors.affiliation: a Department of Nephrology , Haseki Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Abdullah
authors.initials: A
authors.lastname: Sumnu
authors.affiliation: a Department of Nephrology , Haseki Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Oktay
authors.initials: O
authors.lastname: Ozkan
authors.affiliation: b Department of Internal Medicine , Haseki Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yamak
authors.affiliation: c Department of Biochemistry , Haseki Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Macit
authors.initials: M
authors.lastname: Koldas
authors.affiliation: a Department of Nephrology , Haseki Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Ahmet
authors.initials: A
authors.lastname: Behlul
authors.affiliation: d Deparment of Nephrology , Medical Faculty of Bezmialem Vakif University , Istanbul , Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Gursu
authors.affiliation: b Department of Internal Medicine , Haseki Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Esra
authors.initials: E
authors.lastname: Ataoglu
authors.affiliation: a Department of Nephrology , Haseki Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Savas
authors.initials: S
authors.lastname: Ozturk
mesh_terms: D054392:Adipokines / Q000097:blood*; D000367:Age Factors; D000419:Albuminuria / Q000652:urine; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003928:Diabetic Nephropathies / Q000097:blood* / Q000145:classification / Q000209:etiology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007333:Insulin Resistance; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015843:Serpins / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D054392:Adipokines; D015415:Biomarkers; C508600:IL6 protein, human; D007375:Interleukin-1; D015850:Interleukin-6; C507339:SERPINA12 protein, human; D015843:Serpins; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein
keywords: Diabetic nephropathy; glomerular filtration rate; inflammation; proteinuria; vaspin