title: Circadian disturbance and idiopathic central serous chorioretinopathy.
abstract: BACKGROUND
  This present retrospective case control study was designed to evaluate circadian disturbance in patients with chronic idiopathic central serous chorioretinopathy (ICSC).
  
  
  METHODS
  Between January 1st, 2012, and November 30th, 2014, 29 consecutive patients with chronic ICSC examined in a referral setting were compared with a gender-matched and age-matched control group of 29 patients. A history of pharmacologic medication (including corticosteroid treatment), sleep disturbance, irregular working hours, cardiovascular risk factors, and depressive anxiety disorders was noted.
  
  
  RESULTS
  The median age of the patients was 52, and in the control subjects it was 50. The male-female ratio for both groups was 4.8:1. Patients with chronic ISCS were more likely to be exposed to irregular working hours (p < 0.01, OR 9.3 [2.29-37.6]) and to present with overweight than the control subjects (p = 0.016). No significant differences were found for sleeping disturbances, pharmacological medication, cardiovascular risk factors, or depressive anxiety disorders.
  
  
  CONCLUSIONS
  In this preliminary study, the exposition of irregular working hours as a risk factor for chronic ICSC was identified, which had not been previously reported. If further studies confirm these findings, then employment with regular working hours could be recommended for chronic ICSC patients.
authors.affiliation: Service d'Ophtalmologie, Pôle tête et cou, Hôpital Robert Debré, Centre Hospitalo-Universitaire, 51092, Reims, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Setrouk
authors.affiliation: Service d'Ophtalmologie, Pôle tête et cou, Hôpital Robert Debré, Centre Hospitalo-Universitaire, 51092, Reims, France.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Hubault
authors.affiliation: Centre d'évaluation et de traitement de la Douleur, Pôle d'Anesthésie-Réanimation, Centre Hospitalo-Universitaire, 51092, Reims, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Vankemmel
authors.affiliation: Service d'Ophtalmologie, Pôle tête et cou, Hôpital Robert Debré, Centre Hospitalo-Universitaire, 51092, Reims, France.
authors.forename: Olivia
authors.initials: O
authors.lastname: Zambrowski
authors.affiliation: Pôle Thoracique / Cardiaque / Vasculaire, Centre Hospitalo-Universitaire, 51092, Reims, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Nazeyrollas
authors.affiliation: Service d'Endocrinologie, Maladies Métaboliques et de Médecine Interne, Pôle Digestif / Urologie / Néphrologie / Endocrinologie (D.U.N.E.), Centre Hospitalo-Universitaire, 51092, Reims, France.|Pôle Thoracique / Cardiaque / Vasculaire, Centre Hospitalo-Universitaire, 51092, Reims, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Delemer
authors.affiliation: Pôle Thoracique / Cardiaque / Vasculaire, Centre Hospitalo-Universitaire, 51092, Reims, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Durlach
authors.affiliation: Service d'Ophtalmologie, Pôle tête et cou, Hôpital Robert Debré, Centre Hospitalo-Universitaire, 51092, Reims, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Ducasse
authors.affiliation: Service d'Ophtalmologie, Pôle tête et cou, Hôpital Robert Debré, Centre Hospitalo-Universitaire, 51092, Reims, France. carndt@chu-reims.fr.
authors.forename: Carl
authors.initials: C
authors.lastname: Arndt
mesh_terms: D000328:Adult; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D021081:Chronobiology Disorders / Q000150:complications* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014792:Visual Acuity; D055815:Young Adult
keywords: Central serous chorioretinopathy; Circadian; Overweight; Working hours