title: Dermoscopic and Immunohistochemical Changes in Acquired Melanocytic Nevi following Narrow-Band Ultraviolet B Therapy.
abstract: BACKGROUND
  Acquired melanocytic nevi (AMN) have been reported to undergo morphological and dermoscopic changes following exposure to narrow-band ultraviolet B (NB-UVB) radiation.
  
  
  OBJECTIVE
  To study the morphological, dermoscopic and immunohistochemical changes in AMN following NB-UVB radiation.
  
  
  METHODS
  Suberythemogenic NB-UVB sessions were delivered to 40 patients with AMN. For each patient, a minimum of 2 nevi were selected. One nevus was surgically removed from each patient prior to sessions as control; for the other nevus, dermoscopic images were captured before and after NB-UVB sessions. The images were evaluated for changes. At the end, another nevus was surgically removed for immunohistochemical assessment of Ki-67 and melan-A.
  
  
  RESULTS
  Our study showed a statistically significant increase in the size of AMN following NB-UVB radiation. Benign dermoscopic changes were observed. Statistically significant positive correlations were found between some dermoscopic findings and the total cumulative dose of NB-UVB. Immunohistochemical analysis did not show any significant change in the exposed AMN.
  
  
  CONCLUSIONS
  AMN irradiated with repeated suberythemogenic doses of NB-UVB showed benign morphological and dermoscopic changes, and this was confirmed by our immunohistochemical study.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Hesham
authors.initials: H
authors.lastname: Zaher
authors.forename: Dalia
authors.initials: D
authors.lastname: Bassiouny
authors.forename: Rania
authors.initials: R
authors.lastname: Abdel Hay
authors.forename: Nesrin
authors.initials: N
authors.lastname: Samir
authors.forename: Nanees
authors.initials: N
authors.lastname: Ragab
authors.forename: Safinaz
authors.initials: S
authors.lastname: Sayed
mesh_terms: D000328:Adult; D046169:Dermoscopy / Q000379:methods*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D019394:Ki-67 Antigen / Q000378:metabolism*; D058965:MART-1 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000175:diagnosis* / Q000378:metabolism / Q000532:radiotherapy; D012720:Severity of Illness Index; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000532:radiotherapy; D014467:Ultraviolet Therapy / Q000379:methods*
chemical_list: D019394:Ki-67 Antigen; D058965:MART-1 Antigen