title: Interleukin 27 is up-regulated in patients with active inflammatory bowel disease.
abstract: The aim of the study was to characterize and quantify tissue gene and protein expression of IL-27 in ulcerative colitis (UC) and Crohn's disease (CD) patients. This is an observational and cross-sectional study. Fifty-four patients with IBD were studied: 27 active UC, 12 inactive UC, 10 active CD, and 5 inactive CD. All patients belonged to the Inflammatory Bowel Disease Clinic at the Instituto Nacional de Ciencias Médicas y Nutrición. We found that IL-27 gene expression was significantly higher in active UC versus inactive UC group (P = 0.015). The IL-27 mRNA expression was increased in patients with active CD compared with inactive CD disease (P = 0.035). The percentage of IL-27 immunoreactive cells was higher in active UC versus active CD patients and non-inflamed tissue controls. The IL-27 was significantly elevated in active UC and CD patients, and it was associated with disease severity.
authors.affiliation: Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Vasco de Quiroga #15, Col. Belisario Domínguez Sección XVI, 14080, Mexico City, Mexico.
authors.forename: Janette
authors.initials: J
authors.lastname: Furuzawa Carballeda
authors.affiliation: Department of Gastroenterology, Inflammatory Bowel Disease Clinic, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Vasco de Quiroga #15, Col. Belisario Domínguez Sección XVI, 14080, Mexico City, Mexico.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Fonseca Camarillo
authors.affiliation: Department of Gastroenterology, Inflammatory Bowel Disease Clinic, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Vasco de Quiroga #15, Col. Belisario Domínguez Sección XVI, 14080, Mexico City, Mexico. kazuofurusho@hotmail.com.
authors.forename: Jesús K
authors.initials: JK
authors.lastname: Yamamoto-Furusho
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000276:immunology*; D003106:Colon / Q000378:metabolism* / Q000473:pathology; D003424:Crohn Disease / Q000276:immunology*; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D064094:Interleukin-27 / Q000235:genetics / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis; D015854:Up-Regulation
chemical_list: D064094:Interleukin-27; D012333:RNA, Messenger
keywords: Expression; IBD; Immunoregulatory; Inflammation; Interleukin