title: Polycystic ovary syndrome (PCOS) and the risk of coronary heart disease (CHD): a meta-analysis.
abstract: Some studies reported a significant association between polycystic ovary syndrome (PCOS) and risk of cardiovascular disease (CVD). However, the results are controversial. A systematic search was conducted in the PubMed, Science Direct, EMBASE, and Cochrane Library databases. Five case-control studies and 5 cohort studies were selected, involving a total of 104392 subjects in this meta-analysis. PCOS was significantly associated with the increased risk of CVD (OR = 1.30; 95% CI 1.09 - 1.56; P = 0.004). In the subgroup analysis of study design, both case-control studies and prospective cohort studies showed significant results (OR = 1.79; 95% CI 1.16 - 2.77; P = 0.009; OR = 1.20; 95% CI 1.06 - 1.37; P = 0.005), while retrospective cohort studies did not show positive result (OR = 0.91; 95% CI 0.60 - 1.40; P = 0.68). In a further stratified analysis by type of CVD, a significant association was found between PCOS and coronary heart disease (CHD) (OR = 1.44; 95% CI 1.13 - 1.84; P = 0.004). However, no significant association was observed between PCOS and myocardial infarction (MI) (OR = 1.01; 95% CI 0.68 - 1.51; P = 0.95). In conclusion, this meta-analysis suggested that PCOS is significantly associated with increased CHD risk.
authors.affiliation: Department of Geriatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Luqian
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Geriatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Geriatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Huiling
authors.initials: H
authors.lastname: Lou
authors.affiliation: Department of Geriatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Department of Geriatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Geriatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Shaogang
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Geriatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
mesh_terms: D003327:Coronary Disease / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D012307:Risk Factors
keywords: PCOS; Pathology Section; association; cardiovascular disease; meta-analysis