title: Facial Emotion Processing in Aviremic HIV-infected Adults.
abstract: The emotional processing in human immunodeficiency virus-seropositive individuals (HIV+) has been scarcely studied. We included HIV+ individuals (n = 107) on antiretroviral therapy (≥2 years) who completed 6 facial processing tasks and neurocognitive testing. We compared HIV+ and healthy adult (HA) participants (n = 40) in overall performance of each facial processing task. Multiple logistic regressions were conducted to explore predictors of poorer accuracy in those measures in which HIV+ individuals performed poorer than HA participants. We separately explored the impact of neurocognitive status, antiretroviral regimen, and hepatitis C virus (HCV) coinfection on the tasks performance. We found similar performance in overall facial emotion discrimination, recognition, and recall between HIV+ and HA participants. The HIV+ group had poorer recognition of particular negative emotions. Lower WAIS-III Vocabulary scores and active HCV predicted poorer accuracy in recognition of particular emotions. Our results suggest that permanent damage of emotion-related brain systems might persist despite long-term effective antiretroviral therapy.
authors.affiliation: HIV Unit, Internal Medicine Service, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain alicia.gonzalez@idipaz.es.
authors.forename: A
authors.initials: A
authors.lastname: González-Baeza
authors.affiliation: Biological and Health Psychology Department, Universidad Autónoma de Madrid, Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Carvajal
authors.affiliation: Psychiatry Service, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Bayón
authors.affiliation: HIV Unit, Internal Medicine Service, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Pérez-Valero
authors.affiliation: HIV Unit, Internal Medicine Service, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Montes-Ramírez
authors.affiliation: HIV Unit, Internal Medicine Service, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Arribas
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D044966:Anti-Retroviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D003072:Cognition Disorders / Q000209:etiology* / Q000821:virology; D004644:Emotions / Q000187:drug effects / Q000502:physiology*; D005149:Facial Expression; D005260:Female; D006678:HIV / Q000235:genetics; D015658:HIV Infections / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000097:blood; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D008875:Middle Aged; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D011237:Predictive Value of Tests; D021641:Recognition, Psychology / Q000187:drug effects / Q000502:physiology
chemical_list: D044966:Anti-Retroviral Agents; D018950:Lipopolysaccharide Receptors
keywords: Emotional processing; HIV; Neurocognitive impairment