title: Prognostic value of FOXA1 in breast cancer: A systematic review and meta-analysis.
abstract: BACKGROUND
  Despite some published papers analyzing the prognostic role of forkhead-box A1 (FOXA1) in breast cancer, it has not yet been considered as an established prognostic factor in clinical practice. The present meta-analysis evaluated the prognostic value of FOXA1 in breast cancer.
  
  
  METHODS
  PubMed, Web of Science and Embase databases were searched for relevant published literature that evaluated the correlation between FOXA1 and breast cancer. Either a fixed or random effect model was applied to estimate the pooled hazard ratio (HR) for FOXA1 prognosis in breast cancer.
  
  
  RESULTS
  A total of nine articles comprising 6386 breast cancer patients met the inclusion criteria. Among these nine studies, five studies and four studies investigated the prognostic association with disease-free survival (DFS), and overall survival (OS), respectively. Meta-analysis results suggested that high FOXA1 expression was positively associated with DFS (pooled HR: 0.43, 95% CI: 0.23-0.81; P < 0.05) and OS (pooled HR: 0.39, 95% CI: 0.26-0.60; P < 0.05) in breast cancer patients. No publication bias was discovered by Begg's test in this meta-analysis.
  
  
  CONCLUSIONS
  The results from this meta-analysis indicated that elevated FOXA1 expression level was associated with better outcome in breast cancer.
authors.affiliation: Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 31009, China. Electronic address: 3100102375@zju.edu.cn.
authors.forename: Jiafeng
authors.initials: J
authors.lastname: Shou
authors.affiliation: Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 31009, China. Electronic address: 704960737@qq.com.
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Lai
authors.affiliation: Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 31009, China. Electronic address: xujingming0110@163.com.
authors.forename: Jinming
authors.initials: J
authors.lastname: Xu
authors.affiliation: Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 31009, China; Department of Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address: drhuangjian@zju.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics*; D018572:Disease-Free Survival; D005260:Female; D051541:Hepatocyte Nuclear Factor 3-alpha / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D014408:Biomarkers, Tumor; C496499:FOXA1 protein, human; D051541:Hepatocyte Nuclear Factor 3-alpha
keywords: Breast cancer; FOXA1; Prognosis