title: Radiation Associated Angiosarcoma: Case Series from a Community Cancer Center and Review of the Literature.
abstract: BACKGROUND
  Radiation associated angiosarcoma (RAAS) of the breast is a rare, but lethal complication of breast conserving surgery (BCS). Early recognition and knowledge of treatment modalities is imperative for successful treatment. We present the experience of a large community cancer center, with review of the literature.
  
  
  METHODS
  The Christiana Care Department of Pathology and the Helen F. Graham Cancer Center and Research Institute databases were queried from 2001-2011 and 2011-2015 respectively for soft tissue neoplasms of the breast. A total of 2,153 patients with diagnosis of malignant neoplasm of the breast not otherwise specified (NOS) were identified. There were seven cases of RAAS identified.
  
  
  RESULTS
  Seven patients with RAAS were identified. Average age at presentation was 70 years with a range of 58-87. Time from radiation therapy to diagnosis was 8.5 years with a range of 4.0 years to 14.9 years. Five of seven patients presented with skin lesions, all with varying clinical signs. Clinical lymphedema was not identified in any of these patients.
  
  
  CONCLUSIONS
  Radiation associated angiosarcoma of the breast is an aggressive tumor with poor prognosis. Larger studies are needed to evaluate adjuvant treatments; however the small number of cases makes this prohibitive. Genetic testing and potentially targeted therapies are emerging as options for treatment and prevention of this complicated disease process.
authors.forename: Ian N
authors.initials: IN
authors.lastname: Wilhelm
authors.forename: Emily J
authors.initials: EJ
authors.lastname: Penman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D005784:Gene Amplification; D006394:Hemangiosarcoma / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis* / Q000628:therapy; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics; D035583:Rare Diseases; D012189:Retrospective Studies
chemical_list: C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc