title: [Pathogens and clinical characteristics of bacterial infection in hematology department between 2010 and 2014].
abstract: OBJECTIVE
  To analyze the characteristics of distribution and drug resistance of bacterial infection in several different parts of hematology department inpatients of Anhui Provincial Hospital from January 2010 to December 2014, including patients who had received hematopoietic stem cell transplantation (HSCT).
  
  
  METHODS
  Anti-microbial susceptibility test was done by Kirby-Bauer method and automated systems and the data were analysed by WHONET 5.6 software.
  
  
  RESULTS
  A total of 3 312 copies of inspection samples were analyzed, including 2 716 (82%) blood samples and other 596 specimens (18%). 634 bacterial strains were isolated from 3 312 samples (19.14%) including 488 samples (76.97%) from blood culture. 427 (67.35%) bacterial strains were gram-negative, and the other 207 (32.65%) were gram-positive. Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa were most common gram-negative bacterial and the resistant rates to imipenem were 0.8%, 11.8% and 3.3%, respectively. Detection rates of Extended-spectrum beta-lactamases in Escherichia coli and Klebsiella pneumoniae were 83.9% and 75.0%, respectively. At the same time, Coagulase negative Staphylococcus, Streptococcus and Enterococcus were most common kinds of gram-positive bacteria. Methicillin-resistant coagulase negative staphylococcus accounted for 65.9% antibiotic resistance. No vancomycin and/or linezolid and/or tigecycline resistant strains of Staphylococcus spp. and Enterococcus spp. were found in those patients.
  
  
  CONCLUSIONS
  Patients with hematology diseases had a higher risk of bacterial infections, mainly caused by Gram-negative bacteria. There are different distributions of bacterial in different wards.
authors.affiliation: Department of Hematology, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: H W
authors.initials: HW
authors.lastname: Lu
authors.forename: H L
authors.initials: HL
authors.lastname: Liu
authors.forename: X Y
authors.initials: XY
authors.lastname: Zhu
authors.forename: B L
authors.initials: BL
authors.lastname: Tang
authors.forename: C C
authors.initials: CC
authors.lastname: Zheng
authors.forename: H Z
authors.initials: HZ
authors.lastname: Yang
authors.forename: L Q
authors.initials: LQ
authors.lastname: Geng
authors.forename: K Y
authors.initials: KY
authors.lastname: Ding
authors.forename: X B
authors.initials: XB
authors.lastname: Wang
authors.forename: Y S
authors.initials: YS
authors.lastname: Han
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: J S
authors.initials: JS
authors.lastname: Wu
authors.forename: W W
authors.initials: WW
authors.lastname: Zhu
authors.forename: X Y
authors.initials: XY
authors.lastname: Cai
authors.forename: Z M
authors.initials: ZM
authors.lastname: Sun
mesh_terms: D001424:Bacterial Infections / Q000453:epidemiology*; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006402:Hematologic Diseases / Q000453:epidemiology / Q000382:microbiology; D006405:Hematology; D018380:Hematopoietic Stem Cell Transplantation; D006748:Hospital Departments; D006801:Humans; D008826:Microbial Sensitivity Tests