title: Clinical isolates of uropathogenic Escherichia coli ST131 producing NDM-7 metallo-β-lactamase in China.
abstract: Here we report five cases of NDM-7-producing Escherichia coli from patients with bacteriuria in a teaching hospital in mainland China. Two isolates belonged to sequence type 131 (ST131), simultaneously carrying blaCTX-M-15, blaSHV-11, blaTEM-1 and qnrS1. The blaNDM-7 gene was located on a conjugative IncX3-type plasmid bearing blaTEM-1 and qnrS1. These findings indicate the spread of NDM-7 metallo-β-lactamase in a highly resistant and virulent E. coli sequence type in China.
authors.affiliation: Department of Clinical Microbiology, First Affiliated Hospital of Nanchang University, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang 330006, China.
authors.forename: Lian-Hui
authors.initials: LH
authors.lastname: Wang
authors.affiliation: Department of Clinical Microbiology, First Affiliated Hospital of Nanchang University, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang 330006, China.
authors.forename: Pan-Pan
authors.initials: PP
authors.lastname: Liu
authors.affiliation: Department of Clinical Microbiology, First Affiliated Hospital of Nanchang University, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang 330006, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Wei
authors.affiliation: Department of Clinical Microbiology, First Affiliated Hospital of Nanchang University, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang 330006, China. Electronic address: ly13767160474@sina.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Clinical Microbiology, First Affiliated Hospital of Nanchang University, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang 330006, China.
authors.forename: La-Gen
authors.initials: LG
authors.lastname: Wan
authors.affiliation: Department of Infection Disease, First Affiliated Hospital of Nanchang University, Nanchang University, Yong Wai Zheng Jie No. 17, Nanchang 330006, China.
authors.forename: Tian-Xin
authors.initials: TX
authors.lastname: Xiang
authors.affiliation: Institute of Immunotherapy and College of Basic Medicine, Jiangxi Academy of Medical Sciences, Nanchang University, Ba Yi Road No. 603, Nanchang 330006, China.
authors.forename: Yu-Juan
authors.initials: YJ
authors.lastname: Zhang
mesh_terms: D000368:Aged; D001437:Bacteriuria / Q000382:microbiology*; D002681:China; D004927:Escherichia coli Infections / Q000382:microbiology*; D005260:Female; D005838:Genotype; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D008875:Middle Aged; D058885:Multilocus Sequence Typing; D056689:Uropathogenic Escherichia coli / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D001618:beta-Lactamases; C552864:beta-lactamase NDM-1
keywords: Escherichia coli; MLST; Metallo-β-lactamase; Virulent