title: Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG.
abstract: Over the last few years, the ETS transcription factor ERG has emerged as a major regulator of endothelial function. Multiple studies have shown that ERG plays a crucial role in promoting angiogenesis and vascular stability during development and after birth. In the mature vasculature ERG also functions to maintain endothelial homeostasis, by transactivating genes involved in key endothelial functions, while repressing expression of pro-inflammatory genes. Its homeostatic role is lineage-specific, since ectopic expression of ERG in non-endothelial tissues such as prostate is detrimental and contributes to oncogenesis. This review summarises the main roles and pathways controlled by ERG in the vascular endothelium, its transcriptional targets and its functional partners and the emerging evidence on the pathways regulating ERG's activity and expression.
authors.affiliation: Vascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
authors.forename: Aarti V
authors.initials: AV
authors.lastname: Shah
authors.affiliation: Vascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
authors.forename: Graeme M
authors.initials: GM
authors.lastname: Birdsey
authors.affiliation: Vascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom. Electronic address: a.randi@imperial.ac.uk.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Randi
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology*; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D018919:Neovascularization, Physiologic / Q000235:genetics / Q000502:physiology*; D000071230:Transcriptional Regulator ERG / Q000235:genetics / Q000378:metabolism
chemical_list: C072312:ERG protein, human; D000071230:Transcriptional Regulator ERG
keywords: Angiogenesis; ETS transcription factors; Endothelial homeostasis; Gene transcription; Vascular development