title: HOX13 proteins: the molecular switcher in Hoxd bimodal regulation.
abstract: The striking correlation between the genomic arrangement of Hox genes and their temporal and spatial pattern of expression during embryonic development has been a source of fascination since its discovery. This correspondence has been used as a privileged example in the investigation of the connection between genomic architecture and function. In this issue of Genes & Development, Beccari and colleagues (pp. 1172-1186) make a big step forward in understanding Hox gene regulation during limb development by showing the pivotal role of HOXA13 and HOXD13 proteins in the transition from a proximal to a distal type of Hoxd transcriptional regulation.
authors.affiliation: Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas-Universidad de Cantabria, 39011 Santander, Spain.
authors.forename: Marian A
authors.initials: MA
authors.lastname: Ros
mesh_terms: D047108:Embryonic Development; D005121:Extremities / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
chemical_list: D018398:Homeodomain Proteins; D014157:Transcription Factors
keywords: ankle; polycomb; regulatory landscapes; topologically associating domains (TADs); vertebrate limbs; wrist