title: Transcriptional control of insulin-sensitive glucose carrier Glut4 expression in adipose tissue cells.
abstract: In search for new targets for obesity treatment, we have studied the effect of several transcription factors on the conversion of murine preadipocytes from the 3T3-L1 cell line into adipocytes. We have found that knockdown of Prep1 gene expression affects adipogenic differentiation and results in significant increase in the insulin-sensitive glucose carrier Glut4 gene expression.
authors.affiliation: Faculty of Fundamental Medicine, Moscow State University, Lomonosovskii pr. 31, korp. 5, Moscow, 119192, Russia. dpenkov@yahoo.com.
authors.forename: D N
authors.initials: DN
authors.lastname: Penkov
authors.affiliation: Faculty of Fundamental Medicine, Moscow State University, Lomonosovskii pr. 31, korp. 5, Moscow, 119192, Russia.
authors.forename: Zh A
authors.initials: ZhA
authors.lastname: Akopyan
authors.affiliation: Faculty of Fundamental Medicine, Moscow State University, Lomonosovskii pr. 31, korp. 5, Moscow, 119192, Russia.
authors.forename: T N
authors.initials: TN
authors.lastname: Kochegura
authors.affiliation: Faculty of Fundamental Medicine, Moscow State University, Lomonosovskii pr. 31, korp. 5, Moscow, 119192, Russia.
authors.forename: A D
authors.initials: AD
authors.lastname: Egorov
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D015153:Blotting, Western; D002454:Cell Differentiation / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D055785:Gene Knockdown Techniques; D051275:Glucose Transporter Type 4 / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D016133:Polymerase Chain Reaction; D013234:Stem Cells / Q000378:metabolism; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D051275:Glucose Transporter Type 4; D018398:Homeodomain Proteins; C491412:Pknox1 protein, mouse; C495693:Slc2a4 protein, mouse