title: Diabetes Mellitus has no Significant Influence on the Prevalence of Antenatal Asymptomatic Bacteriuria.
abstract: BACKGROUND
  Diabetes is a known risk factor for asymptomatic bacteriuria (ASB). However, the influence of diabetes on antenatal ASB was previously not addressed.
  
  
  OBJECTIVE
  The prevalence of ASB, effect of risk factors and type of isolates and susceptibility patterns were studied in diabetic pregnancy.
  
  
  METHODS
  A total of 311 pregnant women were recruited for this study of which 103 were diabetic and 208 non-diabetic. A clean catch midstream urine samples were collected and cultured. The isolates were identified and antibiotic sensitivity was studied. The data was analysed by Chi-square test.
  
  
  RESULTS
  The prevalence of ASB in diabetic pregnancy was 38.83% (40/10(3); 95% CI: 23.73 - 53.94) and in non-diabetic pregnancy was 37.98% (79/208; CI: 27.28- 48.68). The odds ratio was not significant 1.0225 (95% CU: 0.65 - 1.599; p=0.922) and associated factors such as age and gestational period had no effect. The major isolates were Escherichia coli (25.0%), Staphylococcus aureus (22.5%), Coagulase negative staphylococci (CONS) (20.00%), and Klebsiella pneumonia (20.00%) in diabetic pregnancy and CONS (31.7%), E.coli (24.0%) and K.pneumonia (16.5%) in non-diabetic pregnancy. The isolates of diabetic pregnancy showed highest susceptibility to nitrofurantoin (56.4%), gentamicin (38.5%) and cotrimoxazole (38.5%) whereas that of non-diabetic pregnancy to gentamicin (43.0%), azithromycin (32.9%) and norfloxacin (30.4). There was no significant (p<0.05) difference in the type and susceptibly of the isolates between diabetic and non-diabetic pregnancy.
  
  
  CONCLUSIONS
  Diabetes has no significant influence on the prevalence of ASB in diabetic pregnancy both in terms of isolates and antibiotic susceptibility pattern.
authors.affiliation: Postgraduate Scholar, Department of Microbiology, Kurnool Medical College , Kurnool, Andhra Pradesh, India .
authors.forename: Nissi Priya
authors.initials: NP
authors.lastname: Mekapogu
authors.affiliation: Professor and Head, Department of Microbiology, Kurnool Medical College , Kurnool, Andhra Pradesh, India .
authors.forename: Swarnalatha
authors.initials: S
authors.lastname: Gundela
authors.affiliation: Associate Professor, Department of Microbiology, Kurnool Medical College , Kurnool, Andhra Pradesh, India .
authors.forename: Renuka Devi
authors.initials: RD
authors.lastname: Avula
keywords: Escherichia coli; Gentamicin; Pregnancy