title: Clinicopathological Significance of Vimentin and Cytokeratin Protein in the Genesis of Squamous Cell Carcinoma of Cervix.
abstract: Cervical cancer is one of the commonest types of cancers worldwide especially in developing countries. Intermediate filaments protein family has shown a role in the diagnosis of various cancers, but a few studies are available about the vimentin and cytokeratin roles in the cervical cancer. This case control study aimed to interpret the expression of vimentin and cytokeratin proteins in the development and progression of cervical cancer and its correlation with clinicopathological features. The cytoplasmic expression of vimentin was observed in 40% of cases, but not in inflammatory lesions of cervix. It was noticed that vimentin expression was increasing significantly with high grade of the tumour. Cytokeratin expression was observed in 48.33% and it was noticed that the expression was 62.5% in well differentiated (G1), 45% in moderately differentiated (G2), and 41.66% in poorly differentiated carcinoma, yet statistically insignificant. The expression of vimentin and cytokeratin proteins was not significantly associated with age groups. The current findings concluded a possible role of vimentin in the development and progression of cervical cancer and vimentin marker will be useful in the diagnosis and grading of cervical cancer.
authors.affiliation: Department of Pathology, College of Medicine, Omdurman Islamic University, 382 Omdurman, Sudan.
authors.forename: Nazik Elmalaika O S
authors.initials: NE
authors.lastname: Husain
authors.affiliation: Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah 6666, Saudi Arabia; Department of Histopathology and Cytology, College of Medical Laboratories Science, University of Sciences and Technology, Omdurman, Sudan.
authors.forename: Ali Yousif
authors.initials: AY
authors.lastname: Babiker
authors.affiliation: Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah 6666, Saudi Arabia.
authors.forename: Aqel S
authors.initials: AS
authors.lastname: Albutti
authors.affiliation: Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah 6666, Saudi Arabia.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Alsahli
authors.affiliation: College of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
authors.forename: Salah M
authors.initials: SM
authors.lastname: Aly
authors.affiliation: Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah 6666, Saudi Arabia.
authors.forename: Arshad H
authors.initials: AH
authors.lastname: Rahmani