title: Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed).
abstract: Epilobium angustifolium is a medicinal plant used around the world in traditional medicine for the treatment of many disorders and ailments. Experimental studies have demonstrated that Epilobium extracts possess a broad range of pharmacological and therapeutic effects, including antioxidant, anti-proliferative, anti-inflammatory, antibacterial, and anti-aging properties. Flavonoids and ellagitannins, such as oenothein B, are among the compounds considered to be the primary biologically active components in Epilobium extracts. In this review, we focus on the biological properties and the potential clinical usefulness of oenothein B, flavonoids, and other polyphenols derived from E. angustifolium. Understanding the biochemical properties and therapeutic effects of polyphenols present in E. angustifolium extracts will benefit further development of therapeutic treatments from this plant. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Microbiology and Immunology, Montana State University, Bozeman, MT, 59717, USA.
authors.forename: Igor A
authors.initials: IA
authors.lastname: Schepetkin
authors.affiliation: Department of Microbiology and Immunology, Montana State University, Bozeman, MT, 59717, USA.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Ramstead
authors.affiliation: Department of Microbiology and Immunology, Montana State University, Bozeman, MT, 59717, USA.
authors.forename: Liliya N
authors.initials: LN
authors.lastname: Kirpotina
authors.affiliation: Department of Microbiology and Immunology, Montana State University, Bozeman, MT, 59717, USA.
authors.forename: Jovanka M
authors.initials: JM
authors.lastname: Voyich
authors.affiliation: Department of Microbiology and Immunology, Montana State University, Bozeman, MT, 59717, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Jutila
authors.affiliation: Department of Microbiology and Immunology, Montana State University, Bozeman, MT, 59717, USA.
authors.forename: Mark T
authors.initials: MT
authors.lastname: Quinn
mesh_terms: D031666:Epilobium / Q000737:chemistry*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D059808:Polyphenols / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D059808:Polyphenols
keywords: Epilobium angustifolium; ellagitannin; oenothein B; polyphenol