title: Splenic scintigraphy for further differentiation of unclear (68) Ga-DOTATOC-PET/CT findings: Strengths and limitations.
abstract: Splenic scintigraphy has been described to be a powerful tool in unclear (68 ) Ga-DOTATOC-PET/CT findings, allowing differentiation between somatostatin receptor (Sst)-positive tissue deriving from neuroendocrine tumour (NET) and functioning splenic tissue. However, our own experiences sometimes show a lack of identification on splenic scintigraphy, especially in small lesions, leading to uncertainties regarding the safe identification of NET or splenic tissue. Here, we report on 10 cases with (68) Ga-DOTATOC-PET/CT and (99m) Tc-heat-denaturated red blood cell (HDRBC) scintigraphy and we illustrate the strengths and limitations of (99m) Tc-HDRBC scintigraphy in this context.
authors.affiliation: Clinic of Nuclear Medicine, Jena University Hospital, Jena, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Werner
authors.affiliation: Clinic of Nuclear Medicine, Jena University Hospital, Jena, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Winkens
authors.affiliation: Clinic of Nuclear Medicine, Jena University Hospital, Jena, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Freesmeyer
mesh_terms: D002454:Cell Differentiation; D006801:Humans; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging*; D015282:Octreotide / Q000031:analogs & derivatives; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography; D011877:Radionuclide Imaging / Q000592:standards*; D013154:Spleen / Q000000981:diagnostic imaging*
chemical_list: C499142:Ga(III)-DOTATOC; D009942:Organometallic Compounds; D015282:Octreotide
keywords: 68Ga-DOTATOC-PET/CT; 99mTc-HDRBC Scintigraphy; Sst; spleen; splenic scintigraphy