title: Dose-Dependent Changes in Auditory Sensory Gating in the Prefrontal Cortex of the Cynomolgus Monkey.
abstract: BACKGROUND Sensory gating, often described as the ability to filter out irrelevant information that is repeated in close temporal proximity, is essential for the selection, processing, and storage of more salient information. This study aimed to test the effect of sensory gating under anesthesia in the prefrontal cortex (PFC) of monkeys following injection of bromocriptine, haloperidol, and phencyclidine (PCP). MATERIAL AND METHODS We used an auditory evoked potential that can be elicited by sound to examine sensory gating during treatment with haloperidol, bromocriptine, and PCP in the PFC in the cynomolgus monkey. Scalp electrodes were located in the bilateral PFC and bilateral temporal, bilateral parietal, and occipital lobes. Administration of bromocriptine (0.313 mg/kg, 0.625 mg/kg, and 1.25 mg/kg), haloperidol (0.001 mg/kg, 0.01 mg/kg, and 0.05 mg/kg), and the N-methyl-D-aspartic acid receptor antagonist PCP (0.3 mg/kg) influenced sensory gating. RESULTS We demonstrated the following: (1) Administration of mid-dose bromocriptine disrupted sensory gating (N100) in the right temporal lobe, while neither low-dose nor high-dose bromocriptine impaired gating. (2) Low-dose haloperidol impaired gating in the right prefrontal cortex. Mid-dose haloperidol disrupted sensory gating in left occipital lobe. High-dose haloperidol had no obvious effect on sensory gating. (3) Gating was impaired by PCP in the left parietal lobe. CONCLUSIONS Our studies showed that information processing was regulated by the dopaminergic system, which might play an important role in the PFC. The dopaminergic system influenced sensory gating in a dose- and region-dependent pattern, which might modulate the different stages that receive further processing due to novel information.
authors.affiliation: Second Department of Neurosurgery, First Affiliation Hospital of Kunming Medical University, Kunming, Yunnan, China (mainland).
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China (mainland).
authors.forename: Jinrong
authors.initials: J
authors.lastname: Ya
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China (mainland).
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China (mainland).
authors.forename: Chunmei
authors.initials: C
authors.lastname: Wen
authors.affiliation: Department of Neurosurgery, First Affiliation Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).
authors.forename: Suyue
authors.initials: S
authors.lastname: Zheng
authors.affiliation: , Hainan Jingang Biological Technology Co., Ltd., Haikou, Hainan, China (mainland).
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Tian
authors.affiliation: Department of Neurology, First Affiliation Hospital of Kunming Medical University, Kunming, Yunnan, China (mainland).
authors.forename: Hui
authors.initials: H
authors.lastname: Ren
authors.affiliation: Neuroscience Unit, Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland.
authors.forename: Synnöve
authors.initials: S
authors.lastname: Carlson
authors.affiliation: Second Department of Neurosurgery, First Affiliation Hospital of Kunming Medical University, Kunming, Yunnan, China (mainland).
authors.forename: Hualin
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Radiology, People's Hospital of Hainan, Haikou, Hainan, China (mainland).
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China (mainland).
authors.forename: Wang
authors.initials: W
authors.lastname: Jianhong
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001307:Auditory Perception / Q000502:physiology; D001971:Bromocriptine / Q000494:pharmacology; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008252:Macaca fascicularis; D010622:Phencyclidine / Q000494:pharmacology; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000502:physiology; D055139:Sensory Gating / Q000187:drug effects; D013702:Temporal Lobe / Q000187:drug effects
chemical_list: D001971:Bromocriptine; D010622:Phencyclidine; D006220:Haloperidol