title: Mitochondria-Power Players in Kidney Function?
abstract: A recent study has highlighted the relationship between mitochondrial ATP generation and protection against organ injury following ischaemia-reperfusion injury in the kidney. Kidneys are fuel-hungry organs and only second to the heart in mitochondrial number and oxygen consumption. This article speculates on why this might be so.
authors.affiliation: Mater Research Institute, The University of Queensland Translational Research Institute (TRI), 37 Kent Street Brisbane, 4101 Australia; Mater Clinical School, The University of Queensland, Brisbane, 4067 Australia; Department of Medicine, The University of Melbourne, Heidelberg, 3081 Australia. Electronic address: josephine.forbes@mater.uq.edu.au.
authors.forename: Josephine M
authors.initials: JM
authors.lastname: Forbes
mesh_terms: D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009536:Niacinamide / Q000378:metabolism; D010085:Oxidative Phosphorylation; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology; D010101:Oxygen Consumption / Q000235:genetics / Q000502:physiology; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000378:metabolism
chemical_list: D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D009536:Niacinamide
keywords: PGC1α; kidney injury; nephropathy; nicotinamide; oxidative phosphorylation