title: The Role of Tumor Associated Macrophages in the Tumor Microenvironment: Mechanism and Functions.
abstract: During tumor progression, several types of inflammatory cells are recruited into the tumor site, where they participate in tumor-associated inflammation, such as fibroblasts, granulocytes, lymphocytes and macrophages. Macrophages infiltrating into the tumor microenvironment are termed tumorassociated macrophages (TAMs). In response to multiple stimuli, macrophages undergo recruitment and polarization, and play an important role in further tumor development. In this article, we present a review of the mechanism of macrophage' recruitment, and the role that TAMs play in promoting immunosuppression, tumor progress and metastasis, as well as chemoresistance and future therapeutic strategies.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.forename: Qiaoming
authors.initials: Q
authors.lastname: Zhi
authors.forename: Binhua P
authors.initials: BP
authors.lastname: Zhou
authors.forename: Min
authors.initials: M
authors.lastname: Tao
authors.affiliation: National Cancer Institute (NCI), Frederick, MD 21702, USA. jingyi.liu@nih.gov.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China. liwei10@suda.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D000818:Animals; D006801:Humans; D007108:Immune Tolerance; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D008264:Macrophages / Q000276:immunology / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000276:immunology / Q000473:pathology; D009369:Neoplasms / Q000276:immunology / Q000473:pathology*; D059016:Tumor Microenvironment