title: Endovascular Hypothermia in Acute Ischemic Stroke: Pilot Study of Selective Intra-Arterial Cold Saline Infusion.
abstract: We conducted a pilot feasibility and safety study of selective brain cooling with intra-arterial infusion of cold saline combined with endovascular reperfusion for acute ischemic stroke.
  
  
  
  Patients with large-vessel occlusion within 8 hours after symptom onset were enrolled. All patients received intra-arterial recanalization combined with infusion of cold isotonic saline (4°C) in the ischemic territory through the angiographic catheter.
  
  
  
  Twenty-six patients underwent the procedure, which was technically successful in all. The temperature of ischemic cerebral tissue was decreased by at least 2°C during infusion of the cold solution, and systemic temperature was mildly reduced (maximum 0.3°C). No obvious complications related to intra-arterial hypothermia were observed.
  
  
  
  Selective brain cooling by intra-arterial infusion of cold saline combined with endovascular recanalization therapy in acute ischemic stroke seems feasible and safe.
authors.affiliation: From the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: From the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
authors.forename: Liqiang
authors.initials: L
authors.lastname: Liu
authors.affiliation: From the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
authors.forename: Hongqi
authors.initials: H
authors.lastname: Zhang
authors.affiliation: From the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
authors.forename: Xiaokun
authors.initials: X
authors.lastname: Geng
authors.affiliation: From the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
authors.forename: Liqun
authors.initials: L
authors.lastname: Jiao
authors.affiliation: From the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
authors.forename: Guilin
authors.initials: G
authors.lastname: Li
authors.affiliation: From the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Coutinho
authors.affiliation: From the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
authors.forename: Yuchuan
authors.initials: Y
authors.lastname: Ding
authors.affiliation: From the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
authors.forename: David S
authors.initials: DS
authors.lastname: Liebeskind
authors.affiliation: From the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.). jixm@ccmu.edu.cn.
authors.forename: Xunming
authors.initials: X
authors.lastname: Ji
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000188:drug therapy / Q000628:therapy*; D003080:Cold Temperature; D003131:Combined Modality Therapy; D057510:Endovascular Procedures; D005240:Feasibility Studies; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012965:Sodium Chloride / Q000008:administration & dosage / Q000627:therapeutic use*; D015912:Thrombolytic Therapy
chemical_list: D005343:Fibrinolytic Agents; D012965:Sodium Chloride
keywords: endovascular procedures; hypothermia; intra-arterial infusions; neuroprotection; reperfusion injury