title: Stability of remission rates in a 3-year follow-up of naturalistic treated depressed inpatients.
abstract: Remission is a common outcome of short-term trials and the main goal of acute and longterm treatment. The longitudinal stability of remission has rarely been investigated under naturalistic treatment conditions.
  
  
  
  Naturalistic multisite follow-up study. Three-year symptomatic long-term outcome of initially hospitalized tertiary care patients (N = 784) with major depressive episodes. Remission rates as well as the switch rates between remission and non-remission were reported.
  
  
  
  After one, two and three years 62 %, 59 % and 69 % of the observed patients met criteria for remission. During the follow-up 88 % of all patients achieved remission. 36 % of maintained remission from discharge to 3-years, 12 % of all patients never reached remission and 52 % percent showed a fluctuating course switching from remission to non-remission and vice versa. There was considerable transition between remission and non-remission. For example, from discharge to 1 year, from 1 to 2, and from 2 to 3 years 25 %, 21 % and 11 % lost remission.
  
  
  
  Cumulative outcome rates are encouraging. Absolute rates at predefined endpoints as well as the fluctuations between these outcomes reflect the variable and chronic nature of major depression.
authors.affiliation: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336, Munich, Germany. florian.seemueller@psychiatrie-gap.de.|Department of Psychiatry, Psychosomatic and Psychotherapy, kbo-Lech-Mangfall-Klinik, Garmisch-Patenkirchen, Germany. florian.seemueller@psychiatrie-gap.de.
authors.forename: Florian
authors.initials: F
authors.lastname: Seemüller
authors.affiliation: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Obermeier
authors.affiliation: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Schennach
authors.affiliation: Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Dresden, Technical University Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Bauer
authors.affiliation: Department of Psychiatry and Psychotherapy, Campus, Charité Mitte (CCM), Charitéplatz 1, 10117, Berlin, Germany.
authors.forename: Mazda
authors.initials: M
authors.lastname: Adli
authors.affiliation: Department of Psychiatry and Psychotherapy, Martin-Luther University Halle-Wittenberg, Julius-Kühn-Str.7, 06097, Halle, Germany.|Department of Psychiatry, Psychosomatic and Psychotherapy, Bezirkskrankenhaus Kempten, Robert-Weixlerstrasse 46, 87435, Kempten, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Brieger
authors.affiliation: Department of Psychiatry and Psychotherapy, kbo-Inn-Salzach-Klinikum, Gabersee 7, 83512, Wasserburg, Germany.
authors.forename: Gerd
authors.initials: G
authors.lastname: Laux
authors.affiliation: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336, Munich, Germany.|Department of Psychiatry and Psychotherapy, Vinzenz von Paul Hospital, Rottweil, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Riedel
authors.affiliation: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Falkai
authors.affiliation: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Möller
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007297:Inpatients / Q000706:statistics & numerical data*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge / Q000706:statistics & numerical data; D011446:Prospective Studies; D012074:Remission Induction; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents