title: Advances of Intracranial Electroencephalography in Localizing the Epileptogenic Zone.
abstract: Intracranial electroencephalography (iEEG) provides the best precision in estimating the location and boundary of an epileptogenic zone. Analysis of iEEG in the routine EEG frequency range (0.5-70 Hz) remains the basis in clinical practice. Low-voltage fast activity is the most commonly reported ictal onset pattern in neocortical epilepsy, and low-frequency high-amplitude repetitive spiking is the most commonly reported ictal onset pattern in mesial temporal lobe epilepsy. Recent studies using wideband EEG recording have demonstrated that examining higher (80-1000 Hz) and lower (0.016-0.5 Hz) EEG frequencies can provide additional diagnostic information and help to improve the surgical outcome. In addition, novel computational techniques of iEEG signal analysis have provided new insights into the epileptic network. Here, we review some of these recent advances. Although these sophisticated and advanced techniques of iEEG analysis show promise in localizing the epileptogenic zone, their utility needs to be further validated in larger studies.
authors.affiliation: Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jin
authors.affiliation: Regional Epilepsy Center at Harborview, University of Washington, Seattle, WA, USA.
authors.forename: Norman K
authors.initials: NK
authors.lastname: So
authors.affiliation: Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China. Shuangwang1977@gmail.com.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
mesh_terms: D001921:Brain / Q000503:physiopathology*; D058256:Brain Waves / Q000502:physiology*; D003198:Computer Simulation; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology*; D006801:Humans; D008954:Models, Biological
keywords: Epilepsy; Epileptogenic zone; Intracranial electroencephalography