title: The Reliability of Pharyngeal High Resolution Manometry with Impedance for Derivation of Measures of Swallowing Function in Healthy Volunteers.
abstract: Purpose. We evaluated the intra- and interrater agreement and test-retest reliability of analyst derivation of swallow function variables based on repeated high resolution manometry with impedance measurements. Methods. Five subjects swallowed 10 × 10 mL saline on two occasions one week apart producing a database of 100 swallows. Swallows were repeat-analysed by six observers using software. Swallow variables were indicative of contractility, intrabolus pressure, and flow timing. Results. The average intraclass correlation coefficients (ICC) for intra- and interrater comparisons of all variable means showed substantial to excellent agreement (intrarater ICC 0.85-1.00; mean interrater ICC 0.77-1.00). Test-retest results were less reliable. ICC for test-retest comparisons ranged from slight to excellent depending on the class of variable. Contractility variables differed most in terms of test-retest reliability. Amongst contractility variables, UES basal pressure showed excellent test-retest agreement (mean ICC 0.94), measures of UES postrelaxation contractile pressure showed moderate to substantial test-retest agreement (mean Interrater ICC 0.47-0.67), and test-retest agreement of pharyngeal contractile pressure ranged from slight to substantial (mean Interrater ICC 0.15-0.61). Conclusions. Test-retest reliability of HRIM measures depends on the class of variable. Measures of bolus distension pressure and flow timing appear to be more test-retest reliable than measures of contractility.
authors.affiliation: Department of Gastroenterology, Flinders Medical Centre and School of Medicine, Flinders University, Adelaide, SA 5042, Australia; Human Physiology, Medical Science and Technology, School of Medicine, Flinders University, Adelaide, SA 5042, Australia.
authors.forename: Taher I
authors.initials: TI
authors.lastname: Omari
authors.affiliation: Department of Anaesthesiology and Intensive Care, Örebro University Hospital and School of Medical Sciences, Örebro University, Örebro, Sweden.
authors.forename: Johanna
authors.initials: J
authors.lastname: Savilampi
authors.affiliation: Department of Gastroenterology, Flinders Medical Centre and School of Medicine, Flinders University, Adelaide, SA 5042, Australia.
authors.forename: Karmen
authors.initials: K
authors.lastname: Kokkinn
authors.affiliation: Department of Gastroenterology, Flinders Medical Centre and School of Medicine, Flinders University, Adelaide, SA 5042, Australia.
authors.forename: Mistyka
authors.initials: M
authors.lastname: Schar
authors.affiliation: Swallowing Rehabilitation Research Laboratory, The University of Canterbury Rose Centre for Stroke Recovery and Research, Christchurch, New Zealand.
authors.forename: Kristin
authors.initials: K
authors.lastname: Lamvik
authors.affiliation: Discipline of Speech Pathology & Audiology, Flinders University, Adelaide, SA 5042, Australia.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Doeltgen
authors.affiliation: Department of Gastroenterology, Flinders Medical Centre and School of Medicine, Flinders University, Adelaide, SA 5042, Australia.
authors.forename: Charles
authors.initials: C
authors.lastname: Cock