title: [Assessing resveratrol effect on ocular blood flow in experiment].
abstract: OBJECTIVE
  To study the effect of resveratrol on ocular blood flow in vivo in healthy rats and those that underwent retinal ischemia/reperfusion.
  
  
  METHODS
  The experimental study was performed on 40 Wistar rats (40 eyes). For ocular blood flow evaluation, color Doppler imaging (CDI), power Doppler (PD), and pulsed-wave spectral Doppler ultrasonography were performed using the Voluson E8 Expert ultrasonic diagnostic system (GE Healthcare). All rats were given resveratrol per os for 2 months of the study. Retinal ischemia/reperfusion injury was induced by a subconjunctival injection of endothelin-1. The control group included 10 intact animals.
  
  
  RESULTS
  Signs of ischemic damage of the anterior and posterior eye segments were less pronounced in rats that were given resveratrol during both pre-ischemic (30 days) and post-ischemic (30 days) periods of follow-up. There was also a statistically significant increase in the peak systolic and end diastolic velocity of blood flow as well as a decrease in the resistive index of retrobulbar arteries in those rats that underwent ischemia/reperfusion as compared to the controls.
  
  
  CONCLUSIONS
  Long-term resveratrol use (2 months) has proved effective in improving ocular blood flow in a rat model of retinal ischemia/reperfusion injury.
authors.affiliation: Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
authors.forename: V V
authors.initials: VV
authors.lastname: Neroev
authors.affiliation: Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
authors.forename: T N
authors.initials: TN
authors.lastname: Kiseleva
authors.affiliation: Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
authors.forename: A V
authors.initials: AV
authors.lastname: Chudin
authors.affiliation: Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
authors.forename: A I
authors.initials: AI
authors.lastname: Shchipanova
authors.affiliation: Moscow Helmholtz Research Institute of Eye Diseases, Ministry of Health of the Russian Federation, 14/19 Sadovaya-Chernogryazskaya St., Moscow, Russian Federation, 105062.
authors.forename: K A
authors.initials: KA
authors.lastname: Ramazanova
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D005123:Eye / Q000098:blood supply / Q000378:metabolism; D009880:Ophthalmic Artery / Q000187:drug effects / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D015427:Reperfusion Injury / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology; D000077185:Resveratrol; D012161:Retinal Artery / Q000187:drug effects / Q000503:physiopathology; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors; D013267:Stilbenes / Q000494:pharmacology*; D013995:Time; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color / Q000379:methods; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D020533:Angiogenesis Inhibitors; D000975:Antioxidants; D013267:Stilbenes; D014665:Vasodilator Agents; D012264:Ribonucleotide Reductases; D000077185:Resveratrol