title: [Anti-wrinkle creams with hyaluronic acid: how effective are they?].
abstract: BACKGROUND
  Anti-wrinkle creams containing hyaluronic-acid are often advertised as an efficacious option for the treatment of wrinkles and have even been presented as an option equal to some medical procedures in this regard. Evidence from conclusive and systematic research supporting those claims, however, is widely lacking.
  
  
  OBJECTIVE
  During this trial we examined whether the daily use of anti-wrinkle creams containing hyaluronic-acid has an influence on the depth of wrinkles as well as skin tightness and elasticity.
  
  
  METHODS
  We split up 20 patients into four groups, each of which were assigned an anti-wrinkle cream containing hyaluronic acid for daily use. Four different creams within different price ranges were chosen (Balea, Nivea, Lancôme, Chanel). Before and after the 3 month trial, wrinkle depth was assessed using the PRIMOS(pico) (GFMesstechnik, Teltow, Germany) and skin-tightness and elasticity were evaluated using the Cutometer MP580 (Courage+Khazaka, Cologne, Germany). Additionally, after the trial, questionnaire data on patient satisfaction with their individual product was collected.
  
  
  RESULTS
  The depth of perioral and orbital wrinkles decreased significantly in all groups, with depth reduction ranging between 10% and 20%. Skin-tightness increased significantly in all groups, rising by 13 to 30%. Minimal significant changes in skin-elasticity could only be shown in individual groups.
  
  
  CONCLUSIONS
  The regular use of hyaluronic-acid containing anti-wrinkle creams for over 3 months showed clear and positive effects on wrinkle-depth and skin-tightness. Due to the design of the study, however, no clear indication on the efficacy of hyaluronic acid could be shown.
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland.
authors.forename: Julian
authors.initials: J
authors.lastname: Poetschke
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland.
authors.forename: Hannah
authors.initials: H
authors.lastname: Schwaiger
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Steckmeier
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ruzicka
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland. gerd.gauglitz@med.uni-muenchen.de.
authors.forename: Gerd G
authors.initials: GG
authors.lastname: Gauglitz
mesh_terms: D000328:Adult; D003258:Consumer Behavior; D004548:Elasticity / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000191:economics; D008875:Middle Aged; D015595:Skin Aging / Q000187:drug effects*; D063465:Skin Cream / Q000008:administration & dosage* / Q000191:economics; D016896:Treatment Outcome
chemical_list: D006820:Hyaluronic Acid
keywords: PRIMOS; anti-wrinkle cream; cutometer; hyaluronic acid; wrinkles