title: The Flint Animal Cancer Center (FACC) Canine Tumour Cell Line Panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
abstract: Mammalian cell tissue culture has been a critical tool leading to our current understanding of cancer including many aspects of cellular transformation, growth and response to therapies. The current use of large panels of cell lines with associated phenotypic and genotypic information now allows for informatics approaches and in silico screens to rapidly test hypotheses based on simple as well as complex relationships. Current cell line panels with large amounts of associated drug sensitivity and genomics data are comprised of human cancer cell lines (i.e. NCI60 and GDSC). There is increased recognition of the contribution of canine cancer to comparative cancer research as a spontaneous large animal model with application in basic and translational studies. We have assembled a panel of canine cancer cell lines to facilitate studies in canine cancer and report here phenotypic and genotypic data associated with these cells.
authors.affiliation: Cell and Molecular Biology Program, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.|Flint Animal Cancer Center, Veterinary Medical Center, Colorado State University, Fort Collins, CO, USA.
authors.forename: J S
authors.identifier: http://orcid.org/0000-0002-7614-5447
authors.initials: JS
authors.lastname: Fowles
authors.affiliation: Cell and Molecular Biology Program, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.|Flint Animal Cancer Center, Veterinary Medical Center, Colorado State University, Fort Collins, CO, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Dailey
authors.affiliation: Cell and Molecular Biology Program, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.|Flint Animal Cancer Center, Veterinary Medical Center, Colorado State University, Fort Collins, CO, USA.|University of Colorado Comprehensive Cancer Center, University of Colorado, Denver, CO, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Gustafson
authors.affiliation: Cell and Molecular Biology Program, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.|Flint Animal Cancer Center, Veterinary Medical Center, Colorado State University, Fort Collins, CO, USA.|University of Colorado Comprehensive Cancer Center, University of Colorado, Denver, CO, USA.
authors.forename: D H
authors.initials: DH
authors.lastname: Thamm
authors.affiliation: Cell and Molecular Biology Program, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.|Flint Animal Cancer Center, Veterinary Medical Center, Colorado State University, Fort Collins, CO, USA.|University of Colorado Comprehensive Cancer Center, University of Colorado, Denver, CO, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Duval
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor / Q000187:drug effects / Q000473:pathology; D002470:Cell Survival; D055808:Drug Discovery / Q000379:methods / Q000458:organization & administration; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000662:veterinary*; D020411:Oligonucleotide Array Sequence Analysis; D057170:Translational Research, Biomedical; D014730:Veterinary Medicine / Q000458:organization & administration
chemical_list: D035683:MicroRNAs
keywords: canine cancer; cell line panel; comparative oncology; doxorubicin; drug sensitivity; gene expression; microRNA