title: Synthesis of α-Amidoketones from Vinyl Esters via a Catalytic/Thermal Cascade Reaction.
abstract: A straightforward, modular, and atom-efficient method is reported for the synthesis of α-amidoketones from vinyl esters via a cascade reaction including hydroformylation, condensation with a primary amine, and a rearrangement step giving water as the only byproduct. The reaction sequence can be performed in one pot or as a three-step procedure. The synthetic applicability is demonstrated by the preparation of different α-amidoketones in moderate to good yields.
authors.affiliation: Institut für Technische und Makromolekulare Chemie, RWTH Aachen University , Worringerweg 2, 52074 Aachen, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Holthusen
authors.affiliation: Institut für Technische und Makromolekulare Chemie, RWTH Aachen University , Worringerweg 2, 52074 Aachen, Germany.
authors.forename: Walter
authors.initials: W
authors.lastname: Leitner
authors.affiliation: Institut für Technische und Makromolekulare Chemie, RWTH Aachen University , Worringerweg 2, 52074 Aachen, Germany.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Franciò