title: Immune Cells in Cancer Therapy and Drug Delivery.
abstract: Recent studies indicate the critical role of tumour associated macrophages, tumour associated neutrophils, dendritic cells, T lymphocytes, and natural killer cells in tumourigenesis. These cells can have a significant impact on the tumour microenvironment via their production of cytokines and chemokines. Additionally, products secreted from all these cells have defined specific roles in regulating tumour cell proliferation, angiogenesis, and metastasis. They act in a protumour capacity in vivo as evidenced by the recent studies indicating that macrophages, T cells, and neutrophils may be manipulated to exhibit cytotoxic activity against tumours. Therefore therapy targeting these cells may be promising, or they may constitute drug or anticancer particles delivery systems to the tumours. Herein, we discussed all these possibilities that may be used in cancer treatment.
authors.affiliation: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 166, 02-787 Warsaw, Poland.
authors.forename: Ceren
authors.initials: C
authors.lastname: Eyileten
authors.affiliation: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 166, 02-787 Warsaw, Poland.
authors.forename: Kinga
authors.initials: K
authors.lastname: Majchrzak
authors.affiliation: Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 1a, 02-089 Warsaw, Poland; Cellis Sp. z o.o., Gen. Zajaczka 28, 01-510 Warsaw, Poland.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Pilch
authors.affiliation: Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 1a, 02-089 Warsaw, Poland; Cellis Sp. z o.o., Gen. Zajaczka 28, 01-510 Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Tonecka
authors.affiliation: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 166, 02-787 Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Mucha
authors.affiliation: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 166, 02-787 Warsaw, Poland; Cellis Sp. z o.o., Gen. Zajaczka 28, 01-510 Warsaw, Poland.
authors.forename: Bartlomiej
authors.initials: B
authors.lastname: Taciak
authors.affiliation: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 166, 02-787 Warsaw, Poland; Cellis Sp. z o.o., Gen. Zajaczka 28, 01-510 Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Ulewicz
authors.affiliation: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 166, 02-787 Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Witt
authors.affiliation: Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Boffi
authors.affiliation: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 166, 02-787 Warsaw, Poland; Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 1a, 02-089 Warsaw, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Krol
authors.affiliation: Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 1a, 02-089 Warsaw, Poland; Cellis Sp. z o.o., Gen. Zajaczka 28, 01-510 Warsaw, Poland.
authors.forename: Tomasz P
authors.initials: TP
authors.lastname: Rygiel
mesh_terms: D000818:Animals; D006801:Humans; D008264:Macrophages / Q000378:metabolism / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology; D013601:T-Lymphocytes / Q000378:metabolism / Q000502:physiology; D059016:Tumor Microenvironment / Q000276:immunology