title: Swollen Nuclei Signal from the Grave.
abstract: Eicosanoid signaling plays key pro-inflammatory roles during tissue damage. Now, Enyedi et al. show that swelling of nuclei in cell corpses activates eicosanoid signaling to recruit leukocytes to sites of tissue damage. The enhanced membrane tension in swollen nuclei directly promotes calcium-dependent translocation and activation of enzymes involved in eicosanoid biosynthesis.
authors.affiliation: Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
authors.forename: Wakam
authors.initials: W
authors.lastname: Chang
authors.affiliation: Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: ggg1@columbia.edu.
authors.forename: Gregg G
authors.initials: GG
authors.lastname: Gundersen
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism; D015777:Eicosanoids / Q000096:biosynthesis*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D050356:Lipid Metabolism; D015398:Signal Transduction
chemical_list: D015777:Eicosanoids