title: Traditional Chinese medicines in the management of cardiovascular diseases: a comprehensive systematic review.
abstract: The aim was to perform a systematic review of the efficacy of traditional Chinese medicines (TCM) in cardiovascular disease.
  
  
  
  Electronic databases were searched up to 11 November 2015 for all randomized-controlled trials evaluating the effect of TCM in hypertension, ischaemic stroke, heart failure, coronary heart disease and type 2 diabetes mellitus. Pooled odds ratios (ORs) were calculated using a fixed-effects model.
  
  
  
  Four hypertension studies were eligible for statistical analysis and included 133 patients receiving TCM and 130 control patients. There were significant reductions in systolic blood pressure in patients receiving TCM, comparable to results achieved with pharmaceutical medicines. An OR of 3.781 (95% confidence interval 2.392, 5.977; P = 0.000) was observed for the anti-hypertensive effect of TCM. Significant heterogeneity was present (P = 0.011), with a tendency towards publication bias that did not reach significance (P = 0.05275). Outcome measures for other cardiovascular diseases were inconsistent.
  
  
  
  Certain TCM compounds appear to have significant anti-hypertensive effects, and although some are associated in some studies with improved outcomes in coronary heart disease, heart failure and type 2 diabetes mellitus, the data are inconsistent and will require large-scale randomized-controlled trials to allow full evaluation of any potential therapeutic benefit in these areas.
authors.affiliation: Department of Clinical Pharmacology, Cardiovascular Division, King's College London, London, UK.
authors.forename: Kerry
authors.initials: K
authors.lastname: Layne
authors.affiliation: Department of Clinical Pharmacology, Cardiovascular Division, King's College London, London, UK.
authors.forename: Albert
authors.initials: A
authors.lastname: Ferro
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy*; D016208:Databases, Factual; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Traditional Chinese Medicine; cardiovascular disease; coronary heart disease; hypertension