title: Tanshinone IIA Protects Against Folic Acid-Induced Acute Kidney Injury.
abstract: Tanshinone IIA is a diterpene extracted from Salvia miltiorrhiza, a popular and safe herb medicine that has been widely used in China and other Asian countries. Previous studies have demonstrated the pleiotropic effects of Tanshinone IIA on many disease treatments via its antitoxicity, anti-inflammation, anti-oxidative stress, as well as antifibrosis activities. However, its effect on acute kidney injury (AKI) has not been fully investigated. Here, we show for the first time that systemic administration of Tanshinone IIA can lead to improved kidney function in folic acid-induced kidney injury mice. In the acute phase of AKI, Tanshinone IIA attenuated renal tubular epithelial injury, as determined by histologic changes and the detection of Neutrophil gelatinase-associated lipocalin (NGAL) in the kidney and urine. Additionally, Tanshinone IIA treatment resulted in elevated proliferating cell nuclear antigen (PCNA) expression and decreased inflammatory cells infiltration as well as chemokine expression, suggesting that Tanshinone IIA promoted renal repair following AKI and inhibited local inflammatory response in the injured kidney. This led to decreased long-term fibrosis in the injured kidney, characterized by less accumulation of fibronectin and collagen I in tubulointerstitium. Taken together, these results suggest that Tanshinone IIA may represent a potential approach for AKI treatment.
authors.affiliation: * Department of Nephrology, Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, P.R. China.
authors.forename: Chunming
authors.initials: C
authors.lastname: Jiang
authors.affiliation: * Department of Nephrology, Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.affiliation: * Department of Nephrology, Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, P.R. China.
authors.forename: Qiuyuan
authors.initials: Q
authors.lastname: Shao
authors.affiliation: † Department of Urology, Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, P.R. China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Yan
authors.affiliation: * Department of Nephrology, Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, P.R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jin
authors.affiliation: * Department of Nephrology, Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, P.R. China.
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.affiliation: ‡ Department of Cardiology, Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, P.R. China.
authors.forename: Biao
authors.initials: B
authors.lastname: Xu
mesh_terms: D045784:Abietanes / Q000008:administration & dosage*; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005492:Folic Acid; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D000071068:Lipocalin-2 / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008517:Phytotherapy; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics / Q000378:metabolism; D020011:Protective Agents / Q000008:administration & dosage*; D027561:Salvia miltiorrhiza / Q000737:chemistry*
chemical_list: D045784:Abietanes; D004365:Drugs, Chinese Herbal; D000071068:Lipocalin-2; D018809:Proliferating Cell Nuclear Antigen; D020011:Protective Agents; C021751:tanshinone; D005492:Folic Acid
keywords: Acute Kidney Injury; Apoptosis; Fibrosis; Inflammation; Tanshinone IIA