title: Are We Really Impacting Duration of Untreated Psychosis and Does It Matter?: Longitudinal Perspectives on Early Intervention from the Irish Public Health Services.
abstract: Although early intervention in psychosis is clinically intuitive and theoretically feasible, the reality is that over recent decades the evidence base to support it has not advanced as much as might have been anticipated. Material benefits of early intervention in established psychosis have not been universally demonstrated and much uncertainty continues to surround the field of treatment in the prodromal phase. Undoubtedly methodological differences between studies are relevant and better understanding of different treatment models and the effectiveness of their constituent parts may yield the most benefit, particularly from a public health perspective.
authors.affiliation: School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland; DETECT Early Intervention Services, St John of God Community Services Ltd, Avila House, Block 5, Blackrock Business Park, Blackrock, Co. Dublin, Ireland.
authors.forename: Mary
authors.initials: M
authors.lastname: Clarke
authors.affiliation: Cavan-Monaghan Mental Health Service, COPE Early Intervention Psychosis Service, St Davnet's Hospital, Monaghan, Co. Monaghan, Ireland; Cavan-Monaghan Community Rehabilitation Service, St. Davnet's Hospital, Monaghan, Co. Monaghan, Ireland.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: McDonough
authors.affiliation: DETECT Early Intervention Services, St John of God Community Services Ltd, Avila House, Block 5, Blackrock Business Park, Blackrock, Co. Dublin, Ireland.
authors.forename: Roisin
authors.initials: R
authors.lastname: Doyle
authors.affiliation: Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland; Jiangsu Key Laboratory of Translational Research & Therapy for Neuro-Psychiatric-Disorders, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China. Electronic address: jwadding@rcsi.ie.
authors.forename: John L
authors.initials: JL
authors.lastname: Waddington
mesh_terms: D003362:Cost-Benefit Analysis; D061345:Early Medical Intervention / Q000191:economics; D006801:Humans; D007494:Ireland; D062706:Prodromal Symptoms; D011618:Psychotic Disorders / Q000191:economics / Q000628:therapy*; D013997:Time Factors; D016896:Treatment Outcome
keywords: Duration of untreated psychosis; Early intervention; Outcome; Prodromal phase; Public health service