title: A Fomitopsis pinicola Jeseng Formulation Has an Antiobesity Effect and Protects against Hepatic Steatosis in Mice with High-Fat Diet-Induced Obesity.
abstract: This study investigated the antiobesity effect of an extract of the Fomitopsis pinicola Jeseng-containing formulation (FAVA), which is a combination of four natural components: Fomitopsis pinicola Jeseng; Acanthopanax senticosus; Viscum album coloratum; and Allium tuberosum. High-fat diet- (HFD-) fed male C57BL/6J mice were treated with FAVA (200 mg/kg/day) for 12 weeks to monitor the antiobesity effect and amelioration of nonalcoholic fatty liver diseases (NAFLD). Body and white adipose tissue (WAT) weights were reduced in FAVA-treated mice, and a histological examination showed an amelioration of fatty liver in FAVA-treated mice without decreasing food consumption. Additionally, FAVA reduced serum lipid profiles, leptin, and insulin levels compared with the HFD control group. The FAVA extract suppressed lipogenic mRNA expression levels from WAT concomitantly with the cholesterol biosynthesis level in the liver. These results demonstrate the inhibitory effects of FAVA on obesity and NAFLD in the diet-induced obese (DIO) mouse model. Therefore, FAVA may be an effective therapeutic candidate for treating obesity and fatty liver caused by a high-fat diet.
authors.affiliation: Pohang Center for Evaluation of Biomaterials, Pohang Technopark, Pohang 37668, Republic of Korea; Department of Life Science, Division of Integrative Biosciences and Biotechnology, POSTECH, Pohang 37673, Republic of Korea; R&D Center, NovMetaPharma Co., Ltd., Pohang 37668, Republic of Korea.
authors.forename: Hoe-Yune
authors.initials: HY
authors.lastname: Jung
authors.affiliation: School of Life Science, Handong Global University, Pohang 37554, Republic of Korea.
authors.forename: Yosep
authors.initials: Y
authors.lastname: Ji
authors.affiliation: Pohang Center for Evaluation of Biomaterials, Pohang Technopark, Pohang 37668, Republic of Korea.
authors.forename: Na-Ri
authors.initials: NR
authors.lastname: Kim
authors.affiliation: Pohang Center for Evaluation of Biomaterials, Pohang Technopark, Pohang 37668, Republic of Korea.
authors.forename: Do-Young
authors.initials: DY
authors.lastname: Kim
authors.affiliation: Department of Life Science, Division of Integrative Biosciences and Biotechnology, POSTECH, Pohang 37673, Republic of Korea.
authors.forename: Kyong-Tai
authors.initials: KT
authors.lastname: Kim
authors.affiliation: Pohang Center for Evaluation of Biomaterials, Pohang Technopark, Pohang 37668, Republic of Korea.
authors.forename: Bo-Hwa
authors.initials: BH
authors.lastname: Choi