title: Peri-implant defect regeneration in the diabetic pig: A preclinical study.
abstract: OBJECTIVE
  The study aims to establish a peri-implant dehiscence-type bone defect in a diabetic animal model of human bone repair and to quantify the influence of diabetes on peri-implant bone regeneration.
  
  
  METHODS
  Experimental diabetes was induced in three domestic pigs by streptozotocin. Three animals served as healthy controls. After 12 months four standardized peri-implant dehiscence bone defects were surgically created in the ramus mandibulae. The animals were sacrificed after 90 days. Samples were histologically analyzed to quantify new bone height (NBH), bone-to-implant-contact (BIC), area of newly formed bone (NFB), bone-density (BD), and bone mineralization (BM) in the prepared defect (-D) and in a local control region (-L).
  
  
  RESULTS
  After 90 days, diabetic animals revealed a significantly lower BIC (p = 0.037) and BD (p = 0.041) in the defect area (-D). NBH and BM-D differences within the groups were not significant (p > 0.05). Significant more NFB was measured in the healthy control group (p = 0.046). In the region of local bone BIC-L was significant less in the diabetic group (p = 0.028). In the local control region BD-L and BM-L was lower in the diabetic group compared to the healthy control animals (p > 0.05).
  
  
  CONCLUSIONS
  Histological evidence indicates impaired peri-implant defect regeneration in a diabetic animal model.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstrasse 11, 91054 Erlangen, Germany.
authors.forename: Cornelius
authors.initials: C
authors.lastname: von Wilmowsky
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstrasse 11, 91054 Erlangen, Germany.
authors.forename: Karl Andreas
authors.initials: KA
authors.lastname: Schlegel
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstrasse 11, 91054 Erlangen, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Baran
authors.affiliation: Department of Cranio-, Maxillofacial and Oral Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
authors.forename: Emeka
authors.initials: E
authors.lastname: Nkenke
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstrasse 11, 91054 Erlangen, Germany.
authors.forename: Friedrich Wilhelm
authors.initials: FW
authors.lastname: Neukam
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Glückstrasse 11, 91054 Erlangen, Germany. Electronic address: tobias_moest@uk-erlangen.de.
authors.forename: Tobias
authors.initials: T
authors.lastname: Moest
mesh_terms: D000818:Animals; D015519:Bone Density / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology*; D002113:Calcification, Physiologic / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000473:pathology / Q000503:physiopathology*; D008334:Mandible / Q000601:surgery*; D019930:Mandibular Prosthesis Implantation; D010012:Osteogenesis / Q000502:physiology; D013552:Swine; D014945:Wound Healing / Q000502:physiology
keywords: Bone regeneration; Diabetes; Implant; Osseointegration