title: Bisphenol A and Adiposity in an Inner-City Birth Cohort.
abstract: BACKGROUND
  Early-life exposure to the endocrine disruptor bisphenol A (BPA) may contribute to the development of obesity. Prospective evidence in humans on this topic is limited.
  
  
  OBJECTIVE
  We examined prenatal and early-childhood BPA exposures in relation to childhood measures of adiposity in the Columbia Center for Children's Environmental Health (CCCEH) New York City birth cohort.
  
  
  METHODS
  BPA concentrations were measured in prenatal (n = 375) and child ages 3 (n = 408) and 5 years (n = 518) spot urine samples. Childhood anthropometric and bioelectrical impedance outcomes included body mass index z-scores (BMIZ) at 5 and 7 years, and fat mass index (FMI), percent body fat (%BF), and waist circumference (WC) at 7 years. Associations were evaluated using multiple linear regression with continuous and tertile BPA concentrations.
  
  
  RESULTS
  Prenatal urinary BPA concentrations were positively associated with child age 7 FMI (β = 0.31 kg/m2; 95% CI: 0.01, 0.60, p = 0.04), %BF (β = 0.79; 95% CI: 0.03, 1.55, p = 0.04), and WC (β = 1.29 cm; 95% CI: 0.29, 2.30, p = 0.01), but not BMIZ, or change in BMIZ between ages 5 and 7 years (all p-values > 0.1). FMI results were sex-specific. Child urinary BPA concentrations were not associated with child anthropometric outcomes (all p-values > 0.05).
  
  
  CONCLUSIONS
  Analyses of the CCCEH longitudinal birth cohort found associations between prenatal urinary BPA concentrations and FMI, %BF, and WC. Our results suggest that prenatal BPA exposure may contribute to developmental origins of adiposity. These findings are consistent with several prior studies, raising concern about the pervasiveness of BPA.
  
  
  BACKGROUND
  Hoepner LA, Whyatt RM, Widen EM, Hassoun A, Oberfield SE, Mueller NT, Diaz D, Calafat AM, Perera FP, Rundle AG. 2016. Bisphenol A and adiposity in an inner-city birth cohort. Environ Health Perspect 124:1644-1650; http://dx.doi.org/10.1289/EHP205.
authors.affiliation: Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
authors.forename: Lori A
authors.initials: LA
authors.lastname: Hoepner
authors.forename: Robin M
authors.initials: RM
authors.lastname: Whyatt
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Widen
authors.forename: Abeer
authors.initials: A
authors.lastname: Hassoun
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Oberfield
authors.forename: Noel T
authors.initials: NT
authors.lastname: Mueller
authors.forename: Diurka
authors.initials: D
authors.lastname: Diaz
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Calafat
authors.forename: Frederica P
authors.initials: FP
authors.lastname: Perera
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Rundle