title: Comparison of statin eligibility according to the Adult Treatment Panel III, ACC/AHA blood cholesterol guideline, and presence of carotid plaque by ultrasound in Mexican mestizo patients with rheumatoid arthritis.
abstract: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death in rheumatoid arthritis (RA) patients. Guidelines of the American College of Cardiology and the American Heart Association (ACC/AHA) 2013 and the Adult Treatment Panel III (ATP-III) differ in their strategies to recommend initiation of statin therapy. The presence of carotid plaque (CP) by carotid ultrasound is an indication to begin statin therapy. We aimed to compare the recommendation to initiate statin therapy according to the ACC/AHA 2013 guidelines, ATP-III guidelines, and CP by carotid ultrasound. We then carried out an observational, cross-sectional study of 62 statin-naive Mexican mestizo RA patients, aged 40 to 75, who fulfilled the 1987 or 2010 ACR/European League Against Rheumatism (EULAR) classification criteria. CP was evaluated with B-mode ultrasound. Cohen's kappa (k) was used to assess agreement between ACC/AHA 2013 guidelines, ATP-III guidelines, and the presence of CP, considering a p < 0.05 as statistically significant. Agreement was classified as slight (0.01-0.20), fair (0.21-0.40), moderate (0.41-0.60), substantial (0.61-0.80), and an almost perfect agreement (0.81-1.00). Slight agreement (k = 0.096) was found when comparing statin recommendation between CP and ATP-III. Fair agreement (k = 0.242) was revealed between ACC/AHA 2013 and ATP-III. Comparison between ACC/AHA 2013 and CP showed moderate agreement (k = 0.438). ACC/AHA 2013 guidelines could be an adequate and cost-effective tool to evaluate the need of statin therapy in Mexican mestizo RA patients, with moderate agreement with the presence of CP by ultrasound.
authors.affiliation: Internal Medicine Department, University Hospital Dr. Jose Eleuterio Gonzalez UANL, Francisco I. Madero y Gonzalitos S/N, 64460, Monterrey, Nuevo Leon, Mexico. medint@hospitaluniversitario.org.
authors.forename: Dionicio A
authors.initials: DA
authors.lastname: Galarza-Delgado
authors.affiliation: Cardiology Division, Internal Medicine Department, University Hospital Dr. Jose Eleuterio Gonzalez UANL, Francisco I. Madero y Gonzalitos S/N, 64460, Monterrey, Nuevo Leon, Mexico.
authors.forename: Jose R
authors.initials: JR
authors.lastname: Azpiri-Lopez
authors.affiliation: Rheumatology Division, Internal Medicine Department, University Hospital Dr. Jose Eleuterio Gonzalez UANL, Francisco I. Madero y Gonzalitos S/N, 64460, Monterrey, Nuevo Leon, Mexico.
authors.forename: Iris J
authors.initials: IJ
authors.lastname: Colunga-Pedraza
authors.affiliation: Internal Medicine Department, University Hospital Dr. Jose Eleuterio Gonzalez UANL, Francisco I. Madero y Gonzalitos S/N, 64460, Monterrey, Nuevo Leon, Mexico.
authors.forename: Jesus A
authors.initials: JA
authors.lastname: Cardenas-de la Garza
authors.affiliation: Cardiology Division, Internal Medicine Department, University Hospital Dr. Jose Eleuterio Gonzalez UANL, Francisco I. Madero y Gonzalitos S/N, 64460, Monterrey, Nuevo Leon, Mexico.
authors.forename: Raymundo
authors.initials: R
authors.lastname: Vera-Pineda
authors.affiliation: Radiology Department, University Hospital Dr. Jose Eleuterio Gonzalez UANL, Francisco I. Madero y Gonzalitos S/N, 64460, Monterrey, Nuevo Leon, Mexico.
authors.forename: Judith I
authors.initials: JI
authors.lastname: Garcia-Colunga
authors.affiliation: Internal Medicine Department, University Hospital Dr. Jose Eleuterio Gonzalez UANL, Francisco I. Madero y Gonzalitos S/N, 64460, Monterrey, Nuevo Leon, Mexico.
authors.forename: Rosa I
authors.initials: RI
authors.lastname: Arvizu-Rivera
authors.affiliation: Cardiology Division, Internal Medicine Department, University Hospital Dr. Jose Eleuterio Gonzalez UANL, Francisco I. Madero y Gonzalitos S/N, 64460, Monterrey, Nuevo Leon, Mexico.
authors.forename: Adrian
authors.initials: A
authors.lastname: Martinez-Moreno
authors.affiliation: Endocrinology Division, Internal Medicine Department, University Hospital Dr. Jose Eleuterio Gonzalez UANL, Francisco I. Madero y Gonzalitos S/N, 64460, Monterrey, Nuevo Leon, Mexico.
authors.forename: Jesus Z
authors.initials: JZ
authors.lastname: Villarreal-Perez
authors.affiliation: Radiology Department, University Hospital Dr. Jose Eleuterio Gonzalez UANL, Francisco I. Madero y Gonzalitos S/N, 64460, Monterrey, Nuevo Leon, Mexico.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Elizondo-Riojas
authors.affiliation: Rheumatology Division, Internal Medicine Department, University Hospital Dr. Jose Eleuterio Gonzalez UANL, Francisco I. Madero y Gonzalitos S/N, 64460, Monterrey, Nuevo Leon, Mexico.
authors.forename: Mario A
authors.initials: MA
authors.lastname: Garza Elizondo
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications*; D050197:Atherosclerosis / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002340:Carotid Artery Diseases / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002784:Cholesterol / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D018570:Risk Assessment; D014463:Ultrasonography
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002784:Cholesterol
keywords: Cardiovascular risk; Carotid plaque; Dyslipidemia; Rheumatoid arthritis; Statins; Subclinical atherosclerosis