title: Formation of bioactive N-doped TiO2 on Ti with visible light-induced antibacterial activity using NaOH, hot water, and subsequent ammonia atmospheric heat treatment.
abstract: Titanium (Ti) treated with NaOH and hot water, and heated in an ammmonia (NH3) gas atmosphere for 1 or 3h exhibited in vitro apatite formation within 7days when soaked in simulated body fluid (SBF). Moreover, the treated Ti decomposed methylene blue and showed excellent bactericidal activity against Escherichia coli under visible light irradiation. The surface treatment resulted in the formation of a fine network of N-doped anatase-type titania (TiO2-xNx) on the Ti surface, which was responsible for both the apatite formation in SBF and the visible light-induced antibacterial activity. These preliminary results highlight the efficacy of our simple method for producing novel bioactive Ti with visible light-induced antibacterial activity, which could be applied to orthopaedic and dental implants without the risk of infection.
authors.affiliation: Graduate School of Biomedical Engineering, Tohoku University, Sendai 980-8579, Japan. Electronic address: m-kawa@ecei.tohoku.ac.jp.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kawashita
authors.affiliation: Graduate School of Biomedical Engineering, Tohoku University, Sendai 980-8579, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Endo
authors.affiliation: School of Science and Technology, Meiji University, Kawasaki 214-8571, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Kitakyushu 808-0196, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Miyazaki
authors.affiliation: Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Furuya
authors.affiliation: Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
authors.forename: Kotoe
authors.initials: K
authors.lastname: Yokota
authors.affiliation: Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Abiko
authors.affiliation: Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Kanetaka
authors.affiliation: Graduate School of Dentistry, Tohoku University, Sendai 980-8575, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Takahashi
mesh_terms: D000641:Ammonia / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001031:Apatites / Q000737:chemistry; D001272:Atmosphere; D002384:Catalysis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006358:Hot Temperature; D008027:Light; D008826:Microbial Sensitivity Tests; D009584:Nitrogen / Q000494:pharmacology*; D056951:Photoelectron Spectroscopy; D012972:Sodium Hydroxide / Q000494:pharmacology*; D013499:Surface Properties; D014025:Titanium / Q000494:pharmacology*; D014867:Water / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D001031:Apatites; D014867:Water; C009495:titanium dioxide; D012972:Sodium Hydroxide; D000641:Ammonia; D014025:Titanium; D009584:Nitrogen
keywords: Apatite; Nitrogen; Simulated body fluid; Titania; Titanium; Visible light-induced antibacterial activity