title: Pregnancy Incidence in Female Nasopharyngeal Carcinoma Survivors of Reproductive Age: A Population-Based Study.
abstract: This study evaluated the pregnancy incidence in female nasopharyngeal carcinoma (NPC) survivors of reproductive age.In a nationwide cohort, 2816 female patients 15 to 50 years of age from 1998 to 2010 were identified from the Taiwan National Health Insurance Research database. Comorbidities, complications during pregnancy, and delivery status were recorded. All patients were followed up until a diagnosis of pregnancy, withdrawal from the National Health Insurance system, or December 31, 2011.Overall, 155 patients (incidence rate [IR] = 9.50) were pregnant in the NPC group, whereas 251 patients (IR = 12.80) were pregnant in the non-NPC group. The cumulative incidence of pregnancy in the NPC group was lower than that in the non-NPC group (incidence rate ratio = 0.74, 95% CI = 0.61-0.91). The adjusted hazard ratio of pregnancy in the NPC group was 0.79 with 95% CI = 0.61-0.96, compared with the non-NPC group.The incidence of pregnancy is significantly lower among female NPC survivors of reproductive age than among those without NPC.
authors.affiliation: From the Department of Medical Imaging (B-CL); Department of Nuclear Medicine (R-FY), National Taiwan University Hospital; National Taiwan University College of Medicine (R-FY), Taipei; School of Medicine (C-LL), College of Medicine, China Medical University; Management Office for Health Data (C-LL), China Medical University Hospital; Graduate Institute of Clinical Medical Science and School of Medicine (J-AL, C-HK), College of Medicine, China Medical University; Department of Radiation Oncology (J-AL), China Medical University Hospital, Taichung; Department of Nuclear Medicine (M-CL), E-Da Hospital, I-Shou University, Kaohsiung; Department of Nuclear Medicine and PET Center (C-HK), China Medical University Hospital, Taichung, Taiwan.
authors.forename: Bo-Ching
authors.initials: BC
authors.lastname: Lee
authors.forename: Ruoh-Fang
authors.initials: RF
authors.lastname: Yen
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Lin
authors.forename: Ji-An
authors.initials: JA
authors.lastname: Liang
authors.forename: Ming-Chia
authors.initials: MC
authors.lastname: Lin
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Kao
mesh_terms: D000028:Abortion, Induced / Q000706:statistics & numerical data; D000328:Adult; D000367:Age Factors; D002277:Carcinoma; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000628:therapy*; D009790:Occupations / Q000706:statistics & numerical data; D011247:Pregnancy; D018873:Pregnancy Rate; D011271:Pregnancy, Ectopic / Q000453:epidemiology; D017741:Survivors / Q000706:statistics & numerical data*; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult