title: All Things in Moderation: Prevention of Intestinal Adenomas by DNA Hypomethylation.
abstract: DNA hypomethylation can prevent intestinal tumorigenesis, presumably by reducing epigenetic silencing of tumor-suppressor genes. A study in this issue by Sheaffer and colleagues challenges this notion by showing that severe DNA hypomethylation by tissue-specific Dnmt1 knockout can actually promote intestinal adenoma formation. Cancer Prev Res; 9(7); 509-11. ©2016 AACRSee related article by Sheaffer, et al., p. 534.
authors.affiliation: Van Andel Research Institute, Center for Epigenetics, Grand Rapids, Michigan.
authors.forename: Kwang-Ho
authors.initials: KH
authors.lastname: Lee
authors.affiliation: Van Andel Research Institute, Center for Epigenetics, Grand Rapids, Michigan. peter.laird@vai.org.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Laird
mesh_terms: D000236:Adenoma / Q000235:genetics*; D004247:DNA; D019175:DNA Methylation; D042822:Genomic Instability; D006801:Humans; D007414:Intestinal Neoplasms / Q000235:genetics*
chemical_list: D004247:DNA