title: Forget about thrombosis: Platelets and Alzheimer's disease, yet another sticky situation.
abstract: In this issue of Science Signaling, Donner et al define a highly interesting role for platelets in mediating the pathogenesis of Alzheimer's disease via a mechanism linked to integrin αIIbβ3 outside-in signaling and adenosine diphosphate release. These findings raise the intriguing prospect of harnessing antiplatelet drugs for disrupting the nexus between Aβ-induced activated platelets and Aβ fibril and aggregate formation.
authors.affiliation: Baker IDI Heart and Diabetes Institute, Department of Medicine and Immunology, Monash University, 3004 Melbourne, Victoria 3004, Australia.
authors.forename: James
authors.initials: J
authors.lastname: McFadyen
authors.affiliation: Baker IDI Heart and Diabetes Institute, Department of Medicine and Immunology, Monash University, 3004 Melbourne, Victoria 3004, Australia. karlheinz.peter@bakeridi.edu.au.
authors.forename: Karlheinz
authors.initials: K
authors.lastname: Peter
mesh_terms: D000544:Alzheimer Disease; D001792:Blood Platelets; D051152:Clusterin; D006801:Humans; D010974:Platelet Aggregation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D013927:Thrombosis
chemical_list: D051152:Clusterin; D019039:Platelet Glycoprotein GPIIb-IIIa Complex