title: Nanoscale Semiconductor Devices as New Biomaterials.
abstract: Research on nanoscale semiconductor devices will elicit a novel understanding of biological systems. First, we discuss why it is necessary to build interfaces between cells and semiconductor nanoelectronics. Second, we describe some recent molecular biophysics studies with nanowire field effect transistor sensors. Third, we present the use of nanowire transistors as electrical recording devices that can be integrated into synthetic tissues and targeted intra- or extracellularly to study single cells. Lastly, we discuss future directions and challenges in further developing this area of research, which will advance biology and medicine.
authors.affiliation: Department of Chemistry, James Franck Institute, and the Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637.
authors.forename: John
authors.initials: J
authors.lastname: Zimmerman
authors.affiliation: Biophysical Sciences, University of Chicago, Chicago, Illinois 60637; Medical Scientist Training Program, University of Chicago, Chicago, Illinois 60637.
authors.forename: Ramya
authors.initials: R
authors.lastname: Parameswaran
authors.affiliation: Department of Chemistry, James Franck Institute, and the Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637.
authors.forename: Bozhi
authors.initials: B
authors.lastname: Tian