title: Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis.
abstract: Finding robust brain substrates of mood disorders is an important target for research. The degree to which major depression (MDD) and bipolar disorder (BD) are associated with common and/or distinct patterns of volumetric changes is nevertheless unclear. Furthermore, the extant literature is heterogeneous with respect to the nature of these changes. We report a meta-analysis of voxel-based morphometry (VBM) studies in MDD and BD. We identified studies published up to January 2015 that compared grey matter in MDD (50 data sets including 4101 individuals) and BD (36 data sets including 2407 individuals) using whole-brain VBM. We used statistical maps from the studies included where available and reported peak coordinates otherwise. Group comparisons and conjunction analyses identified regions in which the disorders showed common and distinct patterns of volumetric alteration. Both disorders were associated with lower grey-matter volume relative to healthy individuals in a number of areas. Conjunction analysis showed smaller volumes in both disorders in clusters in the dorsomedial and ventromedial prefrontal cortex, including the anterior cingulate cortex and bilateral insula. Group comparisons indicated that findings of smaller grey-matter volumes relative to controls in the right dorsolateral prefrontal cortex and left hippocampus, along with cerebellar, temporal and parietal regions were more substantial in major depression. These results suggest that MDD and BD are characterised by both common and distinct patterns of grey-matter volume changes. This combination of differences and similarities has the potential to inform the development of diagnostic biomarkers for these conditions.
authors.affiliation: Department of Psychological Medicine, Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
authors.forename: T
authors.initials: T
authors.lastname: Wise
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.|Research Unit, FIDMAG Germanes Hospitalàries - CIBERSAM, Sant Boi de Llobregat, Barcelona, Spain.|Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Radua
authors.affiliation: Mental Health, Parc Taulí Sabadell-CIBERSAM, University Hospital, Sabadell, Barcelona, Spain.|Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Via
authors.affiliation: Mental Health, Parc Taulí Sabadell-CIBERSAM, University Hospital, Sabadell, Barcelona, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Cardoner
authors.affiliation: Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: O
authors.identifier: 0000-0002-1180-2629
authors.initials: O
authors.lastname: Abe
authors.affiliation: Department of Psychological Medicine, Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
authors.forename: T M
authors.initials: TM
authors.lastname: Adams
authors.affiliation: Department of Psychiatry, Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.
authors.forename: F
authors.initials: F
authors.lastname: Amico
authors.affiliation: Department of Psychiatry, The 1st Affiliated Hospital of Kunming Medical University, Kunming, PR China.
authors.forename: Y
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, London, UK.
authors.forename: J H
authors.initials: JH
authors.lastname: Cole
authors.affiliation: Department of Neuroscience, Medical School, Fundação do ABC, Santo André, SP, Brazil.|ABC Center of Studies on Mental Health, Santo André, SP, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: de Azevedo Marques Périco
authors.affiliation: PediMIND Program, Bradley Hospital, Department of Psychiatry, Brown University, East Providence, RI, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Dickstein
authors.affiliation: Academic Clinical Neurology, Department of Neuroscience, University of Sheffield, Sheffield, UK.
authors.forename: T F D
authors.initials: TFD
authors.lastname: Farrow
authors.affiliation: Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany.|Department of Psychiatry, University of Dublin, Trinity College, Dublin, Ireland.
authors.forename: T
authors.initials: T
authors.lastname: Frodl
authors.affiliation: Psychiatric Brain and Body Research Group Jena, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Wagner
authors.affiliation: Department of Psychology, Stanford University, Stanford, CA, USA.
authors.forename: I H
authors.initials: IH
authors.lastname: Gotlib
authors.affiliation: Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Gruber
authors.affiliation: Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea.
authors.forename: B J
authors.initials: BJ
authors.lastname: Ham
authors.affiliation: Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK.|Scottish Imaging Network-A Platform for Scientific Excellence (SINAPSE), Giffnock, UK.|Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
authors.forename: D E
authors.initials: DE
authors.lastname: Job
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.|Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kempton
authors.affiliation: Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Department of Psychology, Dutch Autism and ADHD Research Center, Brain and Cognition, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: P C M P
authors.initials: PCMP
authors.lastname: Koolschijn
authors.affiliation: CADE Clinic, Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
authors.forename: G S
authors.initials: GS
authors.lastname: Malhi
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.|Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Mataix-Cols
authors.affiliation: Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: McIntosh
authors.affiliation: Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
authors.forename: A C
authors.initials: AC
authors.lastname: Nugent
authors.affiliation: Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.|Department of Psychiatry, University of Cambridge, Cambridge, UK.
authors.forename: J T
authors.initials: JT
authors.lastname: O'Brien
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.|Department of Neuroscience, Medical School, University of Sheffield, Sheffield, UK.
authors.forename: S
authors.initials: S
authors.lastname: Pezzoli
authors.affiliation: Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA.
authors.forename: M L
authors.initials: ML
authors.lastname: Phillips
authors.affiliation: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick, NSW, Australia.|Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Australia.
authors.forename: P S
authors.initials: PS
authors.lastname: Sachdev
authors.affiliation: Janssen Research and Development, Titusville, NJ, USA.
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authors.affiliation: Department of Psychiatry and Behavioral Sciences, Center of Excellence on Mood Disorders, Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
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authors.initials: S
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authors.affiliation: The Patrick Wild Centre, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.
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authors.affiliation: Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.
authors.forename: A J
authors.initials: AJ
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authors.affiliation: NeuroImaging Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: van Tol
authors.affiliation: Department of Psychiatry, Leiden University Medical Center, Leiden University, Leiden, The Netherlands.|Leiden Institute for Brain and Cognition, Leiden, The Netherlands.
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authors.initials: NJA
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authors.affiliation: Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: D J
authors.initials: DJ
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authors.affiliation: Department of Psychological Medicine, Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
authors.forename: A H
authors.initials: AH
authors.lastname: Young
authors.affiliation: Department of Psychological Medicine, Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.|School of Psychology, University of East London, London, UK.
authors.forename: C H
authors.initials: CH
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authors.affiliation: Department of Psychological Medicine, Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Cleare
authors.affiliation: Department of Psychological Medicine, Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
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authors.initials: D
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mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D066128:Gray Matter / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D059906:Neuroimaging / Q000379:methods; D017397:Prefrontal Cortex / Q000503:physiopathology