title: [Deep brain stimulation can break vicious circle in obsessive-compulsive disorder].
abstract: Obsessive-compulsive disorder (OCD), characterized by repetitive intrusive thoughts and ritualized behaviors, is a highly debilitating disorder with an estimated lifetime prevalence of about 2 %. Approximately 10 % of these patients have severe symptoms despite having received all available treatments, thus considered treatment refractory. Deep brain stimulation (DBS), a reversible, safe and adaptive method widely used for movement disorders, enables specific targeting of deep brain structures of relevance in OCD. About 60% of the patients with treatment refractory OCD show ameliorated symptoms and improved quality of life with DBS. Taking ethical aspects into consideration DBS is a viable option for patients with treatment refractory OCD though further studies are needed to fully understand and individualize this treatment.
authors.affiliation: Stockholms läns - Psykiatri Nordväst Solna, Sweden Stockholms läns - Psykiatri Nordväst Solna, Sweden.
authors.forename: Long Long
authors.initials: LL
authors.lastname: Chen
authors.affiliation: Neurokirurgiska kliniken, Karolinska sjukhuset - Department of Clinical Neuroscience (CNS), K8 Stockholm, Sweden Neurokirurgiska kliniken, Karolinska sjukhuset - Department of Clinical Neuroscience (CNS), K8 Stockholm, Sweden.
authors.forename: Gaston
authors.initials: G
authors.lastname: Schechtmann
authors.affiliation: Neuroradiologiska kliniken - Department of Clinical Neuroscience (CNS), K8 Stockholm, Sweden Neuroradiologiska kliniken - Department of Clinical Neuroscience (CNS), K8 Stockholm, Sweden.
authors.forename: Patrik
authors.initials: P
authors.lastname: Ring
authors.affiliation: Psykiatri Sydväst - Stockholms läns landsting Stockholm, Sweden Psykiatri Sydväst - Stockholms läns landsting Stockholm, Sweden.
authors.forename: Diana
authors.initials: D
authors.lastname: Djurfeldt
mesh_terms: D003342:Corpus Striatum / Q000502:physiology; D046690:Deep Brain Stimulation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000502:physiology; D009771:Obsessive-Compulsive Disorder / Q000145:classification / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*