title: Epidemiology of endometriosis and its comorbidities.
abstract: Genetic profile, inflammation, hormonal activity, menstrual cyclicity, organochlorine burden, prostaglandin metabolism and immunological factors have been suggested to play a role in the establishment and development of endometriosis. From the epidemiological perspective, several risk factors have been studied to suggest or support the different aetiological hypotheses. Social class and family history apart, the factors most consistently associated with endometriosis are early age at menarche and long and heavy menstrual cycles. These menstrual characteristics (together with nulliparity) reflect increased exposure to menstruation. The other main risk factors are pigmentary traits and sun habits, alcohol intake, use of oral contraceptives, and environmental factors such as exposure to polychlorinated biphenyls and dioxin. All of these factors support a potential role of hormonal mileau and inflammation in the pathogenesis of endometriosis. There is a clear association between endometriosis and gastrointestinal and immunological diseases, ovarian cancer and other gynaecological cancers, and thyroid cancer.
authors.affiliation: Dipartimento Materno Infantile Clinica Ostetrico Ginecologica, Università di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Dipartimento di Scienze Cliniche e di Comunità, Universita' di Milano, Milan, Italy. Electronic address: fabio.parazzini@unimi.it.
authors.forename: F
authors.initials: F
authors.lastname: Parazzini
authors.affiliation: Dipartimento di Scienze Cliniche e di Comunità, Universita' di Milano, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Esposito
authors.affiliation: Dipartimento Materno Infantile Clinica Ostetrico Ginecologica, Università di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Tozzi
authors.affiliation: Dipartimento di Scienze Cliniche e di Comunità, Universita' di Milano, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Noli
authors.affiliation: Dipartimento di Scienze Cliniche e di Comunità, Universita' di Milano, Milan, Italy; UOC Ostetricia e Ginecologia IRCCS Multimedica Ospedale S. Giuseppe, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Bianchi
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015897:Comorbidity; D003267:Contraception; D004715:Endometriosis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000453:epidemiology*; D006801:Humans; D007154:Immune System Diseases / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D012959:Socioeconomic Factors; D055108:Sunbathing
keywords: Comorbidities; Endometriosis; Epidemiology; Risk factors