title: Endovascular thrombectomy in the setting of aortic dissection.
abstract: BACKGROUND
  Recent studies have validated the use of endovascular thrombectomy in large vessel ischemic stroke provided patients are selected appropriately. However, to our knowledge, there have been no previously reported cases of endovascular thrombectomy in patients with aortic dissection. We report three such cases, two with chronic aortic dissections (including one with a history of Marfan syndrome) and another with an acute type B dissection.
  
  
  METHODS
  Case studies and review of relevant literature.
  
  
  RESULTS
  Three patients with a history of aortic dissection presented with acute onset right middle cerebral artery syndromes, two of whom had chronic aortic dissections that were status-post graft repair, while a third had an acute type B aortic dissection that had been managed with a femoral-to-femoral bypass. None of the three were candidates for intravenous tissue plasminogen activator. All three were found to have proximal right M1 occlusions on non-invasive imaging and were taken for endovascular thrombectomy via transfemoral, transradial, and transbrachial approaches, respectively. All three had successful recanalization (with Thrombolysis In Cerebral Infarction (TICI) 2b, TICI 3, and TICI 2b flow, respectively) along with clinical improvement, and none had procedure-related complications.
  
  
  CONCLUSIONS
  These three cases suggest that endovascular thrombectomy is feasible and can be done safely and efficaciously in patients with aortic dissections and those with Marfan syndrome, although the risks and benefits should be considered as part of any decision-making process. Given that endovascular therapy for acute stroke is now in many situations part of standard care, further studies will be necessary to delineate more precise inclusion and exclusion criteria.
authors.affiliation: Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
authors.forename: Michael E
authors.identifier: http://orcid.org/0000-0002-9251-5049
authors.initials: ME
authors.lastname: Reznik
authors.affiliation: Department of Neurology, University of Toledo Medical Center, Toledo, Ohio, USA.
authors.forename: Aixa Damaris
authors.initials: AD
authors.lastname: Espinosa-Morales
authors.affiliation: Department of Neurology, University of Toledo Medical Center, Toledo, Ohio, USA.
authors.forename: Mouhammad A
authors.initials: MA
authors.lastname: Jumaa
authors.affiliation: Department of Neurology, University of Toledo Medical Center, Toledo, Ohio, USA.
authors.forename: Syed
authors.initials: S
authors.lastname: Zaidi
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Ducruet
authors.affiliation: Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.|Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
authors.forename: Ashutosh P
authors.initials: AP
authors.lastname: Jadhav
mesh_terms: D000368:Aged; D000784:Aortic Dissection / Q000000981:diagnostic imaging* / Q000601:surgery*; D001014:Aortic Aneurysm / Q000000981:diagnostic imaging* / Q000601:surgery*; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017131:Thrombectomy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D010959:Tissue Plasminogen Activator
keywords: Dissection; Intervention; Stroke; Thrombectomy