title: Nanomaterial-modulated autophagy: underlying mechanisms and functional consequences.
abstract: Autophagy is an essential lysosome-dependent process that controls the quality of the cytoplasm and maintains cellular homeostasis, and dysfunction of this protein degradation system is correlated with various disorders. A growing body of evidence suggests that nanomaterials (NMs) have autophagy-modulating effects, thus predicting a valuable and promising application potential of NMs in the diagnosis and treatment of autophagy-related diseases. NMs exhibit unique physical, chemical and biofunctional properties, which may endow NMs with capabilities to modulate autophagy via various mechanisms. The present review highlights the impacts of various NMs on autophagy and their functional consequences. The possible underlying mechanisms for NM-modulated autophagy are also discussed.
authors.affiliation: Center for Translational Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Center for Translational Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wei
authors.affiliation: Center for Translational Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
authors.forename: Song
authors.initials: S
authors.lastname: Li
authors.affiliation: Center for Translational Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Le
mesh_terms: D000818:Animals; D001343:Autophagy / Q000187:drug effects*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use*; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D059748:Proteolysis; D013499:Surface Properties
keywords: autophagy; autophagy-modulating effect; nanomaterials