title: Predictors of clinical outcomes after periodontal treatment of aggressive periodontitis: 12-month randomized trial.
abstract: Little is known about the factors that may be used in clinical practice to predict the therapeutic response of aggressive periodontitis patients. The aim of this study was to determine predictors of clinical outcomes after non-surgical treatment of aggressive periodontitis. A total of 24 patients (aged 13-26 years) received oral hygiene instructions, as well as subgingival scaling and root planing. Twelve subjects received systemic azithromycin at random. Clinical variables were assessed at baseline, 3, 6, 9, and 12 months. Baseline microbiological assessment was performed by checkerboard DNA-DNA hybridization. Multivariable models used generalized estimating equations. There were significant improvements in the entire sample in regard to pocket depth, clinical attachment level and bleeding on probing. Significant predictors of a reduction in mean pocket depth were: use of azithromycin, non-molar teeth, generalized disease and baseline pocket depth. Absence of plaque predicted a 0.22 mm higher attachment gain, whereas a baseline pocket depth ≥7 mm predicted a 1.36 mm higher attachment loss. Azithromycin, plaque, and baseline pocket depth were significant predictors of bleeding on probing. The concomitant presence of all three red complex species predicted a 0.78 mm higher attachment loss. It may be concluded that dental plaque, tooth type, disease extent, baseline pocket depth, and use of azithromycin were significant predictors of the clinical response to treatment for aggressive periodontitis in young individuals. Moreover, the presence of multiple periodontal pathogens may predict challenges in achieving a favorable outcome for aggressive periodontitis.
authors.affiliation: Universidade Federal do Rio Grande do Sul, Faculty of Dentistry, Periodontology, Porto Alegre, Brazil.
authors.forename: Alex Nogueira
authors.initials: AN
authors.lastname: Haas
authors.affiliation: Universidade Federal do Rio de Janeiro - UFRJ, Institute of Microbiology, Rio de Janeiro, RJ, Brazil.
authors.forename: Carina Maciel
authors.initials: CM
authors.lastname: Silva-Boghossian
authors.affiliation: Universidade Federal do Rio de Janeiro - UFRJ, Institute of Microbiology, Rio de Janeiro, RJ, Brazil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Colombo
authors.affiliation: Temple University, School of Dentistry, Department of Periodontology, Philadelphia, PA, USA.
authors.forename: Jasim
authors.initials: J
authors.lastname: Albandar
authors.affiliation: Universidade Federal do Rio Grande do Sul, Faculty of Dentistry, Periodontology, Porto Alegre, Brazil.
authors.forename: Rui Vicente
authors.initials: RV
authors.lastname: Oppermann
authors.affiliation: Universidade Federal do Rio Grande do Sul, Faculty of Dentistry, Periodontology, Porto Alegre, Brazil.
authors.forename: Cassiano Kuchenbecker
authors.initials: CK
authors.lastname: Rösing
authors.affiliation: Georgia Regents University, Departments of Periodontics and Oral Biology, Augusta, GA, USA.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Susin
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000628:therapy*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017963:Azithromycin / Q000627:therapeutic use; D003773:Dental Plaque / Q000382:microbiology; D012534:Dental Scaling / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009910:Oral Hygiene / Q000379:methods*; D010512:Periodontal Index; D010519:Periodontium / Q000382:microbiology; D016745:Root Planing / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin