title: Developmental cigarette smoke exposure II: Hippocampus proteome and metabolome profiles in adult offspring.
abstract: Exposure to cigarette smoke during development is linked to neurodevelopmental delays and cognitive impairment including impulsivity, attention deficit disorder, and lower IQ. Utilizing a murine experimental model of "active" inhalation exposure to cigarette smoke spanning the entirety of gestation and through human third trimester equivalent hippocampal development [gestation day 1 (GD1) through postnatal day 21 (PD21)], we examined hippocampus proteome and metabolome alterations present at a time during which developmental cigarette smoke exposure (CSE)-induced behavioral and cognitive impairments are evident in adult animals from this model system. At six month of age, carbohydrate metabolism and lipid content in the hippocampus of adult offspring remained impacted by prior exposure to cigarette smoke during the critical period of hippocampal ontogenesis indicating limited glycolysis. These findings indicate developmental CSE-induced systemic glucose availability may limit both organism growth and developmental trajectory, including the capacity for learning and memory.
authors.affiliation: Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA; Birth Defects Center, University of Louisville, Louisville, KY, USA. Electronic address: rachel.neal@louisville.edu.
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Neal
authors.affiliation: Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of Louisville, Louisville, KY, USA.
authors.forename: Rekha
authors.initials: R
authors.lastname: Jagadapillai
authors.affiliation: Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of Louisville, Louisville, KY, USA.
authors.forename: Cindy
authors.initials: C
authors.lastname: Webb
authors.affiliation: Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA.
authors.forename: Kendall
authors.initials: K
authors.lastname: Stocke
authors.affiliation: Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of Louisville, Louisville, KY, USA; Birth Defects Center, University of Louisville, Louisville, KY, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Greene
authors.affiliation: Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of Louisville, Louisville, KY, USA; Birth Defects Center, University of Louisville, Louisville, KY, USA.
authors.forename: M Michele
authors.initials: MM
authors.lastname: Pisano
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism / Q000187:drug effects; D005260:Female; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D018811:Maternal Exposure / Q000009:adverse effects; D008431:Maternal-Fetal Exchange; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D020543:Proteome / Q000187:drug effects*; D012906:Smoke / Q000009:adverse effects*; D062789:Tobacco Products; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D020543:Proteome; D012906:Smoke; D014028:Tobacco Smoke Pollution
keywords: Cigarette smoke; Developmental; Hippocampus; Metabolome; Murine; Proteome; Tobacco