title: A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients.
abstract: A new species of torque teno mini virus, named TTMV-222, was detected in gingival tissue from periodontitis patients using a viral metagenomics method. The 2803-nucleotide genome of TTMV-222 is closely related to TTMV1-CBD279, with 62.6% overall nucleotide similarity. Genetic analyses of the new virus genome revealed a classic genomic organization but a weak identity with known sequences. The prevalence of TTMV-222 in the periodontitis group (n = 150) was significantly higher than that in the healthy group (n = 150) (p = 0.032), suggesting that the new virus may be associated with inflammation in chronic periodontitis patients. However, this finding requires further investigation.
authors.affiliation: Department of Preventive Dentistry, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Preventive Dentistry, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Swine Infectious Disease, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
authors.forename: Tong-Ling
authors.initials: TL
authors.lastname: Shan
authors.affiliation: Blood Systems Research Institute, San Francisco, California, USA.|Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California, USA.
authors.forename: Xutao
authors.initials: X
authors.lastname: Deng
authors.affiliation: Blood Systems Research Institute, San Francisco, California, USA.|Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Delwart
authors.affiliation: Department of Preventive Dentistry, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, China.
authors.forename: Xi-Ping
authors.initials: XP
authors.lastname: Feng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D055113:Chronic Periodontitis / Q000821:virology*; D005260:Female; D016679:Genome, Viral; D005881:Gingiva / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D022783:Torque teno virus / Q000235:genetics* / Q000302:isolation & purification