title: Versatile molybdenum disulfide based antibacterial composites for in vitro enhanced sterilization and in vivo focal infection therapy.
abstract: Biologically, MoS2-based nanostructures have been intensely applied for the photothermal therapy of cancer, but rarely for antibacterial uses. In this contribution, a multifunctional chitosan (CS) functionalized magnetic MoS2 (abbreviated to CFM) was constructed to nonspecifically combat bacterial infection by integrating bacterial conjugation and enrichment, and NIR-triggered photothermal sterilization. Owing to the abundant introduced amino groups, the CFM complex offers a significantly enhanced conjugation efficiency without obvious specificity towards both Gram-positive and -negative bacteria compared to amino-free magnetic MoS2. The magnetic properties of CFM obtained from iron oxide facilitate the enrichment of a CFM-bacteria conjugate, improving the photothermal efficiency of CFM as a photothermal antibacterial agent. Specifically, after being trapped together with bacteria cells, CFM shows an enhanced in vitro photothermal sterilization ability. In vivo S. aureus-induced abscess treatment studies show faster healing when CFM is used as subcutaneous nano-localized heating sources with the assistance of an external magnet to concentrate the CFM-bacteria conjugate. This work establishes an innovative solution and a novel antimicrobial agent for combating bacterial infections without the use of antibiotics, which may open a new area of application and research for MoS2-based nanostructures.
authors.affiliation: College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, P. R. China. wanglong79@nwsuaf.edu.cn.
authors.forename: Wentao
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Faculty of Pharmacy, School of Medicine, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, P. R. China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Shi
authors.affiliation: College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, P. R. China. wanglong79@nwsuaf.edu.cn.
authors.forename: Yanru
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, P. R. China. wanglong79@nwsuaf.edu.cn.
authors.forename: Shaoxuan
authors.initials: S
authors.lastname: Yu
authors.affiliation: College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, P. R. China. wanglong79@nwsuaf.edu.cn.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Zhu
authors.affiliation: College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, P. R. China. wanglong79@nwsuaf.edu.cn.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, P. R. China. wanglong79@nwsuaf.edu.cn.
authors.forename: Daohong
authors.initials: D
authors.lastname: Zhang
authors.affiliation: College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, P. R. China. wanglong79@nwsuaf.edu.cn.
authors.forename: Baowei
authors.initials: B
authors.lastname: Yang
authors.affiliation: College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, P. R. China. wanglong79@nwsuaf.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, P. R. China. wanglong79@nwsuaf.edu.cn.
authors.forename: Jianlong
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004203:Disinfection; D004220:Disulfides / Q000494:pharmacology*; D005490:Focal Infection / Q000188:drug therapy*; D056945:Hep G2 Cells; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008982:Molybdenum / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D018675:Toxicity Tests
chemical_list: D000900:Anti-Bacterial Agents; D004220:Disulfides; D008982:Molybdenum; C082964:molybdenum disulfide