title: Impact of invasive ventilation on survival when non-invasive ventilation is ineffective in patients with Duchenne muscular dystrophy: A prospective cohort.
abstract: Many patients with DMD undergo tracheostomy. Tracheostomy is associated with certain complications, however its effect on prognosis is not known.
  
  
  
  The relationship between type of mechanical ventilation and survival at 12 years was evaluated in a prospective cohort of patients with Duchenne muscular dystrophy followed in a French reference center for Neuromuscular Diseases. Cox proportional-hazards regressions were used to estimate the hazard ratios associated with risk of switching from non-invasive to invasive ventilation, and with risk of death.
  
  
  
  One hundred and fifty patients were included. Initial use of invasive ventilation was associated with an episode of acute respiratory failure (p < 0.0001) and with a severe clinical status (p < 0.05). Risk of death was associated with swallowing disorders (2.51, IC [1.12-5.66], p < 0.03) and cardiac failure (p < 0.05) but not with type of mechanical ventilation.
  
  
  
  Switching to invasive ventilation is appropriate when non-invasive ventilation is ineffective.
authors.affiliation: CIC 1429, INSERM, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France; Université de Versailles Saint Quentin en Yvelines, INSERM U1179, France; Pôle de ventilation à domicile, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France. Electronic address: boussaid.gh@gmail.com.
authors.forename: Ghilas
authors.initials: G
authors.lastname: Boussaïd
authors.affiliation: Université de Versailles Saint Quentin en Yvelines, INSERM U1179, France; Pôle de ventilation à domicile, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France; Service d'Explorations Fonctionnelles Respiratoires, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lofaso
authors.affiliation: Université de Versailles Saint Quentin en Yvelines, INSERM U1179, France; Pôle de ventilation à domicile, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France; Service d'Explorations Fonctionnelles Respiratoires, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France.
authors.forename: Dante Brasil
authors.initials: DB
authors.lastname: Santos
authors.affiliation: CIC 1429, INSERM, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France; Pôle de ventilation à domicile, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Vaugier
authors.affiliation: CIC 1429, INSERM, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France; Pôle de ventilation à domicile, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Pottier
authors.affiliation: Université de Versailles Saint Quentin en Yvelines, INSERM U1179, France; Pôle de ventilation à domicile, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France; Service d'Explorations Fonctionnelles Respiratoires, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Prigent
authors.affiliation: CIC 1429, INSERM, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France; Université de Versailles Saint Quentin en Yvelines, EA 4047, France; Pôle de ventilation à domicile, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France; Service de Santé Publique, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bahrami
authors.affiliation: CIC 1429, INSERM, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France; Université de Versailles Saint Quentin en Yvelines, INSERM U1179, France; Pôle de ventilation à domicile, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France; Service de Santé Publique, AP-HP, Hôpital Raymond Poincaré, 92380, Garches, France.
authors.forename: David
authors.initials: D
authors.lastname: Orlikowski
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005602:France / Q000453:epidemiology; D006333:Heart Failure / Q000150:complications / Q000453:epidemiology / Q000401:mortality; D006801:Humans; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000150:complications / Q000453:epidemiology / Q000401:mortality / Q000628:therapy*; D063087:Noninvasive Ventilation / Q000009:adverse effects* / Q000379:methods; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000009:adverse effects* / Q000401:mortality; D012131:Respiratory Insufficiency / Q000150:complications / Q000453:epidemiology / Q000401:mortality; D016019:Survival Analysis; D014139:Tracheostomy / Q000009:adverse effects; D055815:Young Adult
keywords: Duchenne muscular dystrophy; Mechanical ventilation; Prospective cohort; Respiratory care