title: Gymnopeptides A and B, Cyclic Octadecapeptides from the Mushroom Gymnopus fusipes.
abstract: Mycochemical study of the mushroom Gymnopus fusipes led to the discovery of two new cyclopeptides. The two compounds, named as gymnopeptides A and B, are unprecedented highly N-methylated cyclic octadecapeptides. Detailed spectroscopic studies, Marfey's analysis, and a preliminary molecular modeling study suggested that both are natural cyclic β hairpins. The isolated compounds exhibited striking antiproliferative activity on several human cancer cell lines, with nanomolar IC50 values.
authors.forename: Attila
authors.initials: A
authors.lastname: Ványolós
authors.affiliation: Spectroscopic Research, Gedeon Richter Plc., Gyömrői út 19-21, 1103 Budapest, Hungary.
authors.forename: Miklós
authors.initials: M
authors.lastname: Dékány
authors.forename: Bernadett
authors.initials: B
authors.lastname: Kovács
authors.affiliation: Spectroscopic Research, Gedeon Richter Plc., Gyömrői út 19-21, 1103 Budapest, Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Krámos
authors.forename: Péter
authors.initials: P
authors.lastname: Bérdi
authors.forename: István
authors.initials: I
authors.lastname: Zupkó
authors.forename: Judit
authors.initials: J
authors.lastname: Hohmann
authors.affiliation: Spectroscopic Research, Gedeon Richter Plc., Gyömrői út 19-21, 1103 Budapest, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Béni
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D009842:Oligopeptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D009842:Oligopeptides; D010456:Peptides, Cyclic