title: Multi-polydioxanone (PDO) scaffold for forehead wrinkle correction: A pilot study.
abstract: BACKGROUND
  Forehead wrinkles are the result of contracture of the frontalis muscle and the skin aging process. Currently, hyaluronic acid filler and botulinum toxin are the main materials used for correction of these wrinkles. In addition, polydioxanone (PDO) thread has also been applied for this treatment.
  
  
  OBJECTIVE
  In order to evaluate the efficacy and safety of multi-PDO scaffold in animal and human skin, we tested PDO insertion in rat and mini-pig models and human volunteers with forehead wrinkles.
  
  
  METHODS
  A stent-shaped multi-PDO scaffold was inserted under the panniculus carnosus of rat dorsal skin and the subcutaneous layer of mini-pig dorsal skin and forehead wrinkles in three human volunteers.
  
  
  RESULTS
  Histological analysis at 12 weeks revealed evidence of de novo collagen synthesis, which was consistent with clinical results on photo evaluation.
  
  
  CONCLUSIONS
  Stent-shaped multi-PDO scaffolds may be another effective and safe treatment modality for reduction of forehead wrinkles.
authors.affiliation: a Medical Beauty Division, R&D Unit, AMOREPACIFIC Corp. Yongin-si , Gyeonggi-do , Korea.
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Ko
authors.affiliation: b EURO Plastic Surgery & Dermatology Clinic , Seoul , Korea.
authors.forename: Joon Yong
authors.initials: JY
authors.lastname: Choi
authors.affiliation: c NAVI Plastic Surgery Clinic , Seoul , Korea.
authors.forename: Hyoung Jin
authors.initials: HJ
authors.lastname: Moon
authors.affiliation: d AESTURA Corp . Seoul , Korea.
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Lee
authors.affiliation: a Medical Beauty Division, R&D Unit, AMOREPACIFIC Corp. Yongin-si , Gyeonggi-do , Korea.
authors.forename: Sue Im
authors.initials: SI
authors.lastname: Jang
authors.affiliation: a Medical Beauty Division, R&D Unit, AMOREPACIFIC Corp. Yongin-si , Gyeonggi-do , Korea.
authors.forename: Il-Hong
authors.initials: IH
authors.lastname: Bae
authors.affiliation: d AESTURA Corp . Seoul , Korea.
authors.forename: Jin Kyu
authors.initials: JK
authors.lastname: Choi
authors.affiliation: a Medical Beauty Division, R&D Unit, AMOREPACIFIC Corp. Yongin-si , Gyeonggi-do , Korea.
authors.forename: Hyuk
authors.initials: H
authors.lastname: Kim
authors.affiliation: a Medical Beauty Division, R&D Unit, AMOREPACIFIC Corp. Yongin-si , Gyeonggi-do , Korea.
authors.forename: Won-Seok
authors.initials: WS
authors.lastname: Park
authors.affiliation: e Departments of Dermatology , Chung-Ang University College of Medicine , Seoul , Korea.
authors.forename: Won Jong
authors.initials: WJ
authors.lastname: Oh
authors.affiliation: e Departments of Dermatology , Chung-Ang University College of Medicine , Seoul , Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Choi
authors.affiliation: e Departments of Dermatology , Chung-Ang University College of Medicine , Seoul , Korea.
authors.forename: Beom Joon
authors.initials: BJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D005546:Forehead / Q000601:surgery*; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D010865:Pilot Projects; D016687:Polydioxanone / Q000008:administration & dosage*; D013552:Swine
chemical_list: D001672:Biocompatible Materials; D016687:Polydioxanone
keywords: Forehead; multi-polydioxanone; scaffold; wrinkle