title: Quality Reporting of Multivariable Regression Models in Observational Studies: Review of a Representative Sample of Articles Published in Biomedical Journals.
abstract: Controlling for confounders is a crucial step in analytical observational studies, and multivariable models are widely used as statistical adjustment techniques. However, the validation of the assumptions of the multivariable regression models (MRMs) should be made clear in scientific reporting. The objective of this study is to review the quality of statistical reporting of the most commonly used MRMs (logistic, linear, and Cox regression) that were applied in analytical observational studies published between 2003 and 2014 by journals indexed in MEDLINE.Review of a representative sample of articles indexed in MEDLINE (n = 428) with observational design and use of MRMs (logistic, linear, and Cox regression). We assessed the quality of reporting about: model assumptions and goodness-of-fit, interactions, sensitivity analysis, crude and adjusted effect estimate, and specification of more than 1 adjusted model.The tests of underlying assumptions or goodness-of-fit of the MRMs used were described in 26.2% (95% CI: 22.0-30.3) of the articles and 18.5% (95% CI: 14.8-22.1) reported the interaction analysis. Reporting of all items assessed was higher in articles published in journals with a higher impact factor.A low percentage of articles indexed in MEDLINE that used multivariable techniques provided information demonstrating rigorous application of the model selected as an adjustment method. Given the importance of these methods to the final results and conclusions of observational studies, greater rigor is required in reporting the use of MRMs in the scientific literature.
authors.affiliation: From the Unitat de Suport a la Recerca-Lleida, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona (JR); Universitat International de Catalunya, Facultat de Medicina i Ciències de la Salut, Sant Cugat (JR, JMM-S); Department of Basic Medical Sciences, Universitat de Lleida, Lleida (CF); Oblikue Consulting (CF); Institut Universitari d'Investigació en Atenció Primària Jordi Gol, Barcelona (AR-L); and Tobacco Control Unit, Catalan Istitute of Oncology, Hospitalet de Llobregat (JMM-S), Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Real
authors.forename: Carles
authors.initials: C
authors.lastname: Forné
authors.forename: Albert
authors.initials: A
authors.lastname: Roso-Llorach
authors.forename: Jose M
authors.initials: JM
authors.lastname: Martínez-Sánchez
mesh_terms: D035843:Biomedical Research / Q000592:standards*; D015986:Confounding Factors, Epidemiologic; D006801:Humans; D055811:Journal Impact Factor; D016014:Linear Models; D016015:Logistic Models; D015999:Multivariate Analysis; D064887:Observational Studies as Topic / Q000592:standards*; D016016:Proportional Hazards Models; D012107:Research Design / Q000592:standards*