title: Comparing the Recurrence of Vulvovaginal Candidiasis in Patients Undergoing Prophylactic Treatment with Probiotic and Placebo During the 6 Months.
abstract: This is a randomized, double-blind, clinical/comparative trial study, involving the recurrence of vaginal candidiasis (VVC) after initial treatment with oral fluconazole in patients undergoing prophylactic management with a probiotic and placebo for 6 months. Fifty-nine VVC patients who were diagnosed based on their history, physical examination, and culture of vaginal discharge were initially treated by a single dose of 150 mg fluconazole. According to the table of random numbers, the sample was divided into two groups. The patients from one group took probiotics, while those from the other group took a placebo, with all of them being continuously monitored for 6 months. The patients complaining of vaginal candidiasis symptoms, such as burning, pruritus, and a vaginal (curd-like) discharge, were examined and the discharge was cultured for candida. The positive cultures were considered to be recurring for the patients in each group. Thirty-one cases from the placebo group and 28 cases from the probiotic group were carefully observed. In total, the 6-month recurrence in the control group was eleven (35.5 %) and in the research group was two (7.2 %). The results from Fisher's exact test for the value p = 0.01 and OR 0.14 95 % CI (0.028-0.7) showed significant recurrence in the placebo group. The findings demonstrated that taking probiotics withazole antifungal drugs could be highly effective in treating VVC, resulting in a lower recurrence rate as well.
authors.affiliation: Yazd Research and Clinical Center for OB\GYN, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Robab
authors.initials: R
authors.lastname: Davar
authors.affiliation: Yazd Research and Clinical Center for OB\GYN, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. fahimeh.nokhostin@yahoo.com.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Nokhostin
authors.affiliation: Yazd Research and Clinical Center for OB\GYN, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Eftekhar
authors.affiliation: Yazd Research and Clinical Center for OB\GYN, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Leili
authors.initials: L
authors.lastname: Sekhavat
authors.affiliation: Department of Biology, PNU Taft University, Yazd, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Bashiri Zadeh
authors.affiliation: Yazd Research and Clinical Center for OB\GYN, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Farimah
authors.initials: F
authors.lastname: Shamsi
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002181:Candidiasis, Vulvovaginal / Q000628:therapy*; D004311:Double-Blind Method; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D019936:Probiotics; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole
keywords: Probiotic; Recurrence; Vulvovaginal candidiasis