title: Mometasone furoate nasal spray for the treatment of asthma.
abstract: BACKGROUND
  Asthma is a common respiratory disease characterized by airway inflammation, bronchoconstriction and airway hyperresponsiveness and symptoms such as coughing, wheezing, shortness of breath and chest tightness. Allergic rhinitis is a common comorbidity in asthma and glucocorticoids are the key stone in the treatment of both diseases. Mometasone furoate is a potent synthetic steroid with a very high receptor affinity and a low bioavailability and shown to be superior compared to other inhaled corticosteroids. It is not clear whether the use of mometasone furoate nasal spray (MFNS) is associated with an improvement in asthma control.
  
  
  METHODS
  This current paper reviews the current knowledge on the effect of mometasone furoate nasal spray in the treatment of asthma and includes clinical trials in which both subjective and objective outcomes are assessed.
  
  
  CONCLUSIONS
  To date, only few clinical studies have investigated the effect of nasal steroids in the treatment of asthma. The studies investigating the effect of MFNS report contradicting results, although the most well-designed study to answer this question finds no improvement in asthma control. Thus, it seems unlikely that asthma guidelines will be influenced by the current knowledge on the effect of MFNS in the treatment of asthma.
authors.affiliation: a Respiratory Research Unit , Bispebjerg University Hospital , Copenhagen , Denmark.
authors.forename: Howraman
authors.initials: H
authors.lastname: Meteran
authors.affiliation: a Respiratory Research Unit , Bispebjerg University Hospital , Copenhagen , Denmark.
authors.forename: Vibeke
authors.initials: V
authors.lastname: Backer
mesh_terms: D000281:Administration, Intranasal; D018926:Anti-Allergic Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D000068656:Mometasone Furoate / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D059085:Nasal Sprays; D016896:Treatment Outcome
chemical_list: D018926:Anti-Allergic Agents; D005938:Glucocorticoids; D059085:Nasal Sprays; D000068656:Mometasone Furoate
keywords: Allergic rhinitis; asthma; mometasone furoate nasal spray; treatment