title: Antidepressant-like effects and mechanisms of flavonoids and related analogues.
abstract: Flavonoids, possessing a basic phenylbenzopyrone core, are important components of the human diet, and are found in many medicinal plants. Flavonoids include chalcones, flavanones and their derivatives. Synthetic and natural isolated flavonoids display an enormous number of biological activities such as antitumor, antiplatelet, anti-malarial, anti-inflammatory, antidepressant and anticonvulsant properties. This review article focuses on the antidepressant-like effect, structure-activity relationship and mechanism of action of total flavonoid extracts isolation from natural sources, flavonoid compounds and their related analogues.
authors.affiliation: Food and Pharmacy College, Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhejiang, Zhoushan, 316022, PR China. Electronic address: glp730@163.com.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Guan
authors.affiliation: Food and Pharmacy College, Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhejiang, Zhoushan, 316022, PR China.
authors.forename: Bing-Yu
authors.initials: BY
authors.lastname: Liu
mesh_terms: D000928:Antidepressive Agents / Q000737:chemistry*; D047188:Chalcones; D044950:Flavanones; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D010946:Plants, Medicinal / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000928:Antidepressive Agents; D047188:Chalcones; D044950:Flavanones; D005419:Flavonoids
keywords: Antidepressant-like effect; Chalcones; Flavanones; Flavonoids; Structure-activity relationship