title: Graft-versus-host Disease-associated Angiomatosis Treated With Topical Timolol Solution.
abstract: BACKGROUND
  Scleroderma-like graft-versus-host disease (GVHD) is an uncommon subtype of chronic GVHD. Vascular lesions rarely arise within areas of scleroderma-like changes and until recent- ly have not been considered to be related entities. Kaffenberg et al1 have grouped this heterogeneous collection of vascular lesions under the term GVHD-associated angiomatosis. Treatment modalities thus far have been mostly ineffective. Topical timolol solution has been used in the treatment of superficial infantile hemangiomas with good success. Here the authors report the first case of GVHD-associated angiomatosis treated with topical timolol solution.
  
  
  METHODS
  Timolol 0.5% solution was applied daily to 3 lesions on the lower extremities of their patient for 3 months.
  
  
  RESULTS
  All lesions decreased in friability and frequency of spontaneous hemorrhage. Le- sions remained stable in size throughout treatment duration, with no growth observed in any lesion. Granulation tissue surrounding all lesions was markedly reduced after the treatment period.
  
  
  CONCLUSIONS
  Topical timolol remains a promising therapeutic option in the treat- ment of GVHD-associated angiomatosis.
authors.affiliation: Department of Dermatology, St. Joseph Mercy Hospital.
authors.forename: Benjamin R
authors.initials: BR
authors.lastname: Bashline
authors.affiliation: Department of Dermatology, St. Joseph Mercy Hospital.
authors.forename: Michael
authors.initials: M
authors.lastname: Mortazie
authors.affiliation: Department of Pathology, St. Joseph Mercy Hospital, Ann Arbor, MI.
authors.forename: Brian
authors.initials: B
authors.lastname: Schapiro
authors.affiliation: Department of Dermatology, St. Joseph Mercy Hospital.
authors.forename: David
authors.initials: D
authors.lastname: Fivenson
mesh_terms: D000328:Adult; D000798:Angiomatosis / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications*; D006801:Humans; D007866:Leg; D017445:Skin Diseases, Vascular / Q000188:drug therapy*; D013999:Timolol / Q000008:administration & dosage*
chemical_list: D003879:Dermatologic Agents; D013999:Timolol