title: [Concomitant Drug Reaction with Eosinophilia and Systemic Symptom Syndrome from Ethambutol and Autoimmune Hepatitis from Isoniazid].
abstract: Anti-tuberculosis drugs can produce levels of hepatotoxicity ranging from mild elevation of aminotransferase to severe acute hepatitis. A few cases of drug-induced autoimmune hepatitis or the drug reaction with eosinophilia and systemic symptom (DRESS) syndrome by anti-tuberculosis medications have been reported. However, concomitant occurrence of these two disorders has not been reported. Here, we present a case of severe acute hepatitis with DRESS syndrome and autoimmune hepatitis resulting from primary standard anti-tuberculosis drugs. Both conditions were successfully treated with a systemic steroid regimen.
authors.affiliation: Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Joon Hyuk
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Nae Yun
authors.initials: NY
authors.lastname: Heo
authors.affiliation: Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Seung Ha
authors.initials: SH
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Chan Sun
authors.initials: CS
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Kyeong Min
authors.initials: KM
authors.lastname: Jo
authors.affiliation: Department of Pathology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Woo Gyeong
authors.initials: WG
authors.lastname: Kim
authors.affiliation: Department of Pathology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Kyung Han
authors.initials: KH
authors.lastname: Nam
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use; D003523:Cycloserine / Q000627:therapeutic use; D063926:Drug Hypersensitivity Syndrome / Q000209:etiology*; D004359:Drug Therapy, Combination; D004802:Eosinophilia / Q000209:etiology; D004977:Ethambutol / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D019693:Hepatitis, Autoimmune / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects / Q000627:therapeutic use*; D064704:Levofloxacin / Q000627:therapeutic use; D008099:Liver / Q000201:enzymology; D011515:Prothionamide / Q000627:therapeutic use; D012720:Severity of Illness Index; D014376:Tuberculosis / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D064704:Levofloxacin; D011515:Prothionamide; D004977:Ethambutol; D003523:Cycloserine; D000410:Alanine Transaminase; D007538:Isoniazid
keywords: Antitubercular agents; Drug hypersensitivity syndrome; Hepatitis, autoimmune