title: [Epidemiology of pertussis in adults and related factors in Tianjin, 2005-2014].
abstract: OBJECTIVE
  To understand the epidemiological characteristics of pertussis in adults and related factors in Tianjin.
  
  
  METHODS
  Descriptive epidemiological analysis was conducted by using the epidemiological data of pertussis in adults in Tianjin during 2005-2014. The transmission routes of family cluster cases were analyzed. ELISA was conducted to detect pertussis immunity levels in adults aged 18-83 years.
  
  
  RESULTS
  The pertussis cases in adults accounted for 28.57%(252/882)of the total cases in Tianjin , the annual incidence of pertussis in adults was 0.16/100 000. The highest incidence was 0.46/100 000 in 2013. The age specific proportion of the cases was highest in age group 21-30 years(36.12%, 91/252). Three household transmission routes of pertussis were identified, the major one was adult-to-infant(77.78%,98/126). The parents were the infection sources of 81.64% of infant cases(80/98). Of the 904 study subjects, the average positive rate of antibody against pertussis was 55.20%(95%CI: 51.96%-58.44%). There were significant differences in antibody positive rate among different age groups(P= 0.015), and which had the linear correlation with the reported annual incidence(r=0.98, P=0.003)and showed upward trend(χ(2)=11.79, P=0.001).
  
  
  CONCLUSIONS
  The study indicated that adults have become the population at high risk for pertussis and the major infection sources for infants in Tianjin. The positive rate of antibody against pertussis was low in adults. It is suggested to conduct pertussis vaccination in adults.
authors.affiliation: Expanded Program on Immunization Department, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
authors.forename: H T
authors.initials: HT
authors.lastname: Huang
authors.affiliation: Expanded Program on Immunization Department, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Gao
authors.affiliation: Pathogen Detection Department, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Expanded Program on Immunization Department, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
authors.forename: J
authors.initials: J
authors.lastname: Sun
authors.affiliation: Pathogen Detection Department, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
authors.forename: P
authors.initials: P
authors.lastname: Liu
authors.affiliation: Expanded Program on Immunization Department, Binghai New District Hangu Centers for Disease Control and Prevention, Tianjin 300480, China.
authors.forename: L J
authors.initials: LJ
authors.lastname: Wang
authors.affiliation: Program on Immunization Department, Hongqiao District Centers for Disease Control and Prevention, Tianjin 300132, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.affiliation: Program on Immunization Department, Beichen District Centers for Disease Control and Prevention, Tianjin 300400, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Expanded Program on Immunization Department, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000906:Antibodies; D001886:Bordetella pertussis; D002681:China / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015994:Incidence; D007223:Infant; D037342:Pertussis Toxin / Q000276:immunology; D010567:Pertussis Vaccine / Q000276:immunology*; D014611:Vaccination; D014917:Whooping Cough / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D000906:Antibodies; D010567:Pertussis Vaccine; D037342:Pertussis Toxin