title: Ruthenium-Catalyzed Enantioselective Hydrogenation of 1,8-Naphthyridine Derivatives.
abstract: The first asymmetric hydrogenation of 2,7-disubstituted 1,8-naphthyridines catalyzed by chiral cationic ruthenium diamine complexes has been developed. A wide range of 1,8-naphthyridine derivatives were effectively hydrogenated to give 1,2,3,4-tetrahydro-1,8-naphthyridines with up to 99% ee and full conversions. The method provides a practical and facile approach to the preparation of valuable chiral heterocyclic building blocks and useful motifs for a new kind of P,N-ligand.
authors.affiliation: CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (ICCAS) , Beijing 100190, P. R. China.
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Ma
authors.affiliation: CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (ICCAS) , Beijing 100190, P. R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.affiliation: CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (ICCAS) , Beijing 100190, P. R. China.
authors.forename: Youran
authors.initials: Y
authors.lastname: Liu
authors.affiliation: CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (ICCAS) , Beijing 100190, P. R. China.
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: He
authors.affiliation: CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (ICCAS) , Beijing 100190, P. R. China.|Collaborative Innovation Center of Chemical Science and Engineering, Tianjing 300072, P. R. China.
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Fan