title: Anterior lamina cribrosa surface position in idiopathic intracranial hypertension and glaucoma.
abstract: OBJECTIVE
  To compare the anterior lamina cribrosa (LC) surface position in patients with idiopathic intracranial hypertension (IIH), primary open-angle glaucoma (high-tension glaucoma [HTG] and normal-tension glaucoma [NTG]), and healthy controls using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT).
  
  
  METHODS
  This was a retrospective, cross-sectional observational study of 11 eyes with IIH, 20 eyes with HTG, 20 eyes with NTG, and 37 control eyes. Serial horizontal B-scans of the optic nerve head were obtained using EDI-OCT. The LC depth, defined as the distance from the Bruch membrane opening plane to the anterior LC surface, was manually measured on selected B-scans covering the central three-quarters of the optic nerve head in each eye.
  
  
  RESULTS
  Mean LC depth in patients with IIH (325.2 ± 92.1 µm) was significantly (p&lt;0.01) decreased compared to control subjects (387.8 ± 53.9 µm). In HTG, the mean LC depth (493.0 ± 115.2 µm) was significantly increased compared to NTG (376.6 ± 27.1 µm, p&lt;0.05) and control subjects (332.7 ± 53.1 µm, p&lt;0.001). The trans-LC pressure difference (TLPD) (intraocular pressure - cerebrospinal fluid pressure) was positively correlated with the LC depth (r = 0.96, p&lt;0.001) and inversely correlated with visual field perimetric mean deviation in patients with IIH (r = -0.88, p&lt;0.001).
  
  
  CONCLUSIONS
  The LC is positioned anteriorly in patients with IIH and posteriorly in glaucomatous eyes compared to normal controls. The positional changes of the LC could be a result of the TLPD between the intraocular and intracranial pressure compartments.
authors.affiliation: Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen - Denmark.
authors.forename: Jenni M
authors.initials: JM
authors.lastname: Villarruel
authors.affiliation: Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen - Denmark.
authors.forename: Xiao Q
authors.initials: XQ
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen - Denmark.
authors.forename: Daniella
authors.initials: D
authors.lastname: Bach-Holm
authors.affiliation: Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen - Denmark.
authors.forename: Steffen
authors.initials: S
authors.lastname: Hamann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications*; D064368:Healthy Volunteers; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D057066:Low Tension Glaucoma / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology*; D010211:Papilledema / Q000209:etiology; D011559:Pseudotumor Cerebri / Q000150:complications*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods; D014065:Tonometry, Ocular; D014792:Visual Acuity / Q000502:physiology; D014794:Visual Fields / Q000502:physiology