title: The synthesis and synergistic antifungal effects of chalcones against drug resistant Candida albicans.
abstract: To identify effective and low toxicity synergistic antifungal compounds, 24 derivatives of chalcone were synthesized to restore the effectiveness of fluconazole against fluconazole-resistant Candida albicans. The minimal inhibitory concentration (MIC80) and the fractional inhibitory concentration index (FICI) of the antifungal synergist fluconazole were measured against fluconazole-resistant Candida albicans. This was done via methods established by the clinical and laboratory standards institute (CLSI). Of the synthesized compounds, 2'-hydroxy-4'-methoxychalcone (8) exhibited the most potent in vitro (FICI=0.007) effects. The structure activity relationship of the compounds are then discussed.
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, China; School of Pharmacy, Weifang Medical University, Weifang, Shandong Province 261053, China.
authors.forename: Yuan-Hua
authors.initials: YH
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Huai-Huai
authors.initials: HH
authors.lastname: Dong
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Zhao
authors.affiliation: School of Pharmacy, Weifang Medical University, Weifang, Shandong Province 261053, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Weifang Medical University, Weifang, Shandong Province 261053, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yan
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, China. Electronic address: jiangyy@smmu.edu.cn.
authors.forename: Yuan-Ying
authors.initials: YY
authors.lastname: Jiang
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, China. Electronic address: ysjinsmmu@163.com.
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Jin
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D025141:Drug Resistance, Fungal / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D047188:Chalcones
keywords: Antifungal effect; Candida albicans; Chalcone; Fluconazole; Synergist