title: Ultra-high-pressure liquid chromatography tandem mass spectrometry method for the determination of 9 organophosphate flame retardants in water samples.
abstract: Few methods are available for comprehensive organophosphate flame retardants (PFRs) detection in water and wastewater. Gas chromatography has been employed previously, but this approach is less selective, not amenable for use with deuterated standards and can suffer unfavorable fragmentation. Ultra-high-pressure liquid chromatography tandem mass spectrometry (UHPLC-QqQ-MS/MS) has become the most promising platform, already applied successfully for analysis of selected PFRs in some environmental matrices like water and wastewater. However, the presence of some interferences from the dissolvent, the equipment and the used materials should be taken into account. The procedure involves: •The first determination of PFRs by UHPLC-QqQ-MS/MS using a trap column to distinguish the interferences coming from the instrument and mobile phases.•The optimization of the LC separation to distinguish all target compounds and their interferences.•This method coupled to a solid-phase extraction (SPE) improve the detection and quantification of PFRs.
authors.affiliation: Food and Environmental Safety Research Group (SAMA), Desertification Research Centre (CIDE-UV, GV, CSIC), Faculty of Pharmacy, University of Valencia, Burjassot, Valencia, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Lorenzo
authors.affiliation: Environmental Forensic and Landscape Chemistry Research Group, Desertification Research Centre-CIDE (Spanish Council for Scientific Research, University of Valencia, Generalitat Valenciana), Carretera Moncada- Náquera km 4.5 (Campus IVIA), 46113 Moncada, Valencia, Spain; Earth Surface Science, Institute for Biodiversity and Ecosystems Dynamics, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.
authors.forename: Julián
authors.initials: J
authors.lastname: Campo
authors.affiliation: Food and Environmental Safety Research Group (SAMA), Desertification Research Centre (CIDE-UV, GV, CSIC), Faculty of Pharmacy, University of Valencia, Burjassot, Valencia, Spain.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Picó
keywords: Analysis of organophosphate flame retardants in water by SPE and UHPLC–MS/MS using a trap column.; Interferences; LC–MS/MS; Organophosphate flame retardants; Trap column; Water; solid phase extraction