title: Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery.
abstract: Brain delivery is one of the major challenges in drug development because of the high number of patients suffering from neural diseases and the low efficiency of the treatments available. Although the blood-brain barrier (BBB) prevents most drugs from reaching their targets, molecular vectors - known as BBB shuttles - offer great promise to safely overcome this formidable obstacle. In recent years, peptide shuttles have received growing attention because of their lower cost, reduced immunogenicity, and higher chemical versatility than traditional Trojan horse antibodies and other proteins.
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain. meritxell.teixido@irbbarcelona.org ernest.giralt@irbbarcelona.org.
authors.forename: Benjamí
authors.initials: B
authors.lastname: Oller-Salvia
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain. meritxell.teixido@irbbarcelona.org ernest.giralt@irbbarcelona.org.
authors.forename: Macarena
authors.initials: M
authors.lastname: Sánchez-Navarro
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain. meritxell.teixido@irbbarcelona.org ernest.giralt@irbbarcelona.org and Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain.
authors.forename: Ernest
authors.initials: E
authors.lastname: Giralt
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain. meritxell.teixido@irbbarcelona.org ernest.giralt@irbbarcelona.org.
authors.forename: Meritxell
authors.initials: M
authors.lastname: Teixidó
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D016503:Drug Delivery Systems; D006801:Humans; D008954:Models, Biological; D010455:Peptides / Q000737:chemistry / Q000378:metabolism
chemical_list: C531860:Angiopep-2; D010455:Peptides