title: Reduced serologic sensitivity to influenza A virus illness among inactivated influenza vaccinees.
abstract: We compared ≥4-fold increases in antibody titers by hemagglutination inhibition assay to RT-PCR results among 42 adults with PCR-confirmed influenza A virus illnesses. Serologic sensitivity was higher among unvaccinated (69%, 95% confidence interval [CI]=48-90%) than vaccinated healthcare personnel (38%, 95% CI=29-46%) in a 2010-11 prospective cohort.
authors.affiliation: Influenza Division/NCIRD/CDC, Atlanta, GA 30333, United States. Electronic address: isq8@cdc.gov.
authors.forename: Mark G
authors.initials: MG
authors.lastname: Thompson
authors.affiliation: Division of Pediatric Infectious Diseases, Baylor Scott & White Health, Texas A&M HSC COM, Temple, TX 76508, United States.
authors.forename: Manjusha J
authors.initials: MJ
authors.lastname: Gaglani
authors.affiliation: The Center for Health Research, Kaiser Permanente Northwest, Portland, OR 97227, United States.
authors.forename: Allison L
authors.initials: AL
authors.lastname: Naleway
authors.affiliation: Influenza Division/NCIRD/CDC, Atlanta, GA 30333, United States.
authors.forename: Samuel H
authors.initials: SH
authors.lastname: Dowell
authors.affiliation: Influenza Division/NCIRD/CDC, Atlanta, GA 30333, United States.
authors.forename: Sarah
authors.initials: S
authors.lastname: Spencer
authors.affiliation: Abt Associates, Cambridge, MA 02138, United States.
authors.forename: Sarah
authors.initials: S
authors.lastname: Ball
authors.affiliation: Influenza Division/NCIRD/CDC, Atlanta, GA 30333, United States.
authors.forename: Min
authors.initials: M
authors.lastname: Levine
authors.affiliation: Influenza Division/NCIRD/CDC, Atlanta, GA 30333, United States.
authors.forename: Alicia
authors.initials: A
authors.lastname: Fry
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D006282:Health Personnel; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus; D007252:Influenza Vaccines / Q000627:therapeutic use*; D007251:Influenza, Human / Q000517:prevention & control*; D016014:Linear Models; D008297:Male; D011446:Prospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D015164:Vaccines, Inactivated / Q000627:therapeutic use
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated
keywords: Antibody; Hemagglutinin inhibition; Immunogenicity; Influenza; Influenza vaccine; Seroconversion; Vaccine failure