title: Microsurgical removal of craniopharyngioma: endoscopic and transcranial techniques for complication avoidance.
abstract: Craniopharyngioma remains a challenging entity for neurosurgeons because of its midline, deep seated location and intimate relationship with critical neurovascular structures. Although gross total resection is ideal, the need to reduce surgical morbidity and preserve quality of life has led to a number of neurosurgical approaches which have attained this goal. Here we discuss the commonly used approaches for surgical resection and highlight technical considerations to reduce the potential of complications. We also discuss the mutually exclusive underlying genetic lesions in different histopathological subtypes that will likely lead to future treatment options for these tumors.
authors.affiliation: Division of Neurosurgery, The Hospital for Sick Children, Suite 1503, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.|Department of Surgery, University of Toronto, Toronto, ON, Canada.
authors.forename: Saira
authors.initials: S
authors.lastname: Alli
authors.affiliation: Division of Neurosurgery, The Hospital for Sick Children, Suite 1503, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.|Department of Surgery, University of Toronto, Toronto, ON, Canada.
authors.forename: Semra
authors.initials: S
authors.lastname: Isik
authors.affiliation: Division of Neurosurgery, The Hospital for Sick Children, Suite 1503, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. james.rutka@sickkids.ca.|Department of Surgery, University of Toronto, Toronto, ON, Canada. james.rutka@sickkids.ca.
authors.forename: James T
authors.initials: JT
authors.lastname: Rutka
mesh_terms: D003397:Craniopharyngioma / Q000601:surgery*; D006801:Humans; D007431:Intraoperative Complications; D008866:Microsurgery / Q000009:adverse effects / Q000379:methods*; D038361:Neuronavigation; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000379:methods*; D010911:Pituitary Neoplasms / Q000601:surgery*; D011183:Postoperative Complications
keywords: Approaches; Craniopharyngioma; Endoscopic; Surgery; Transcranial