title: Iodine nutrition status and thyroid disorders: a cross-sectional study from the Xinjiang Autonomous Region of China.
abstract: Iodine nutritional status and its influence on thyroid function have been thoroughly investigated in many places in China, but little is known about Xinjiang province, where multiple minorities are living in a special geographical location and have different lifestyles compared with people from other parts of China. The aim of this study was to evaluate iodine status and thyroid disorders in two major ethnic groups living in the Xinjiang region of China.
  
  
  
  A total of 2253 residents over the age of 18 years who had lived in Xinjiang for more than 3 years were enrolled. Urinary iodine concentration (UIC), serum thyroid hormone concentrations and thyroid autoantibodies were measured, and thyroid ultrasonography was performed.
  
  
  
  The median UIC was 130.7 μg/l in adults. Among the subjects, those with deficient UIC levels were 34.4%. The prevalence of overt hyper- and hypothyroidism in the iodine-deficient group was higher than in the iodine-sufficient group (1.3% vs 0%, χ2=3.891, P=0.049; 4.8% vs 2.8%, χ2=8.715, P=0.003, respectively), and subclinical hypothyroidism was more frequent in the iodine-deficient group than in the iodine-excess group (19.6% vs 12.5%, χ2=4.529, P=0.033).
  
  
  
  One-third of the population is still iodine deficient in Xinjiang. Uyghur females are more susceptible to hypothyroidism and thyroid autoimmune diseases. Thyroid disorders, especially hyper/hypothyroidism and subclinical hypothyroidism, are more likely to be prevalent in an iodine-deficient population.
authors.affiliation: Department of Endocrinology, People's Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Endocrinology, People's Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, China.
authors.forename: J
authors.initials: J
authors.lastname: Zynat
authors.affiliation: Department of Endocrinology, People's Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, People's Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, China.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, People's Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, China.
authors.forename: R
authors.initials: R
authors.lastname: Osiman
authors.affiliation: Department of Endocrinology, People's Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology, People's Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, China.
authors.forename: A
authors.initials: A
authors.lastname: Tuhuti
authors.affiliation: Department of Endocrinology, People's Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, China.
authors.forename: M
authors.initials: M
authors.lastname: Abdunaimu
authors.affiliation: Department of Endocrinology, People's Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, China.
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, People's Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, China.
authors.forename: X
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of Endocrinology, People's Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, China.
authors.forename: S
authors.initials: S
authors.lastname: Xing
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007455:Iodine / Q000172:deficiency* / Q000652:urine; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D015995:Prevalence; D013959:Thyroid Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000652:urine; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D055815:Young Adult
chemical_list: D013972:Thyrotropin; D007455:Iodine