title: Recommendations for Addressing Harm-Benefit Analysis and Implementation in Ethical Evaluation - Report from the AALAS-FELASA Working Group on Harm-Benefit Analysis - Part 2.
abstract: International regulations and guidelines strongly suggest that the use of animal models in scientific research should be initiated only after the authority responsible for the review of animal studies has concluded a well-thought-out harm-benefit analysis (HBA) and deemed the project to be appropriate. The AALAS-FELASA working group on HBA has performed a literature review and based on this review, proposed a method for HBA. Examples of the working group's approach are included in this report.
authors.affiliation: Chief, Comparative Medicine Branch, NIEHS/NIH, Research Triangle Park, NC, USA kathy.laber@nih.gov.
authors.forename: Kathy
authors.initials: K
authors.lastname: Laber
authors.affiliation: AAALAC International, Frederick, MD, USA.
authors.forename: Christian E
authors.initials: CE
authors.lastname: Newcomer
authors.affiliation: Chief Veterinary Officer, Sanofi, Marcy l'Etoile, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Decelle
authors.affiliation: Department of Laboratory Animal Science, GlaxoSmithKline, Research Triangle, Park, NC, USA.
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Everitt
authors.affiliation: AAALAC International, Pamplona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Guillen
authors.affiliation: University of Bergen, Department of Clinical Medicine, Bergen, Norway.
authors.forename: Aurora
authors.initials: A
authors.lastname: Brønstad
mesh_terms: D032761:Animal Experimentation / Q000941:ethics*; D000827:Animal Welfare / Q000592:standards*; D000818:Animals; D000830:Animals, Laboratory; D017408:Guidelines as Topic / Q000592:standards*; D006801:Humans; D018570:Risk Assessment; D012307:Risk Factors
keywords: ethical review; harm–benefit