title: Seizures associated with low-dose tramadol for chronic pain treatment.
abstract: The management of cancer pain still poses a major challenge for clinicians. Tramadol is a centrally acting synthetic opioid analgesic. Its well-known side effects include nausea, vomiting, and dizziness; seizures are a rare side effect. Some reports have found that tramadol triggers seizure activity at high doses, whereas a few preclinical studies have found that this seizure activity is not dose-related. We herein present a case involving a patient with laryngeal cancer who developed seizures while on low-dose oral tramadol.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
authors.forename: Serbülent Gökhan
authors.initials: SG
authors.lastname: Beyaz
authors.affiliation: Department of Anesthesiology, Sakarya University Training and Research Hospital, Sakarya, Turkey.
authors.forename: Tuğba
authors.initials: T
authors.lastname: Sonbahar
authors.affiliation: Department of Anesthesiology, Sakarya University Training and Research Hospital, Sakarya, Turkey.
authors.forename: Fikret
authors.initials: F
authors.lastname: Bayar
authors.affiliation: Department of Anesthesiology and Pain Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
authors.forename: Ali Fuat
authors.initials: AF
authors.lastname: Erdem
keywords: Cancer; low dose; pain; seizures; tramadol