title: A tryptophan-containing fluorescent intramolecular complex as a designer peptidic proton sensor.
abstract: Pyrene and tryptophan groups judiciously placed on a novel molecular scaffold, namely, bispidine exhibited fluorescence due to the formation of an unprecedented emissive intramolecular complex in polar solvents. Upon protonation, the emission signal from the pyrene unit enhances at the expense of the emission signal from the complex. The probe demonstrates good sensitivity, excellent selectivity, and adequate reversibility towards proton sensing. The present design based on the bispidine scaffold opens up newer opportunities for the design of novel bispidine-peptide sensors.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India. haridasv@chemistry.iitd.ac.in sipandey@chemistry.iitd.ac.in.
authors.forename: V
authors.initials: V
authors.lastname: Haridas
authors.affiliation: Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India. haridasv@chemistry.iitd.ac.in sipandey@chemistry.iitd.ac.in.
authors.forename: Anita
authors.initials: A
authors.lastname: Yadav
authors.affiliation: Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India. haridasv@chemistry.iitd.ac.in sipandey@chemistry.iitd.ac.in.
authors.forename: Sakshi
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India. haridasv@chemistry.iitd.ac.in sipandey@chemistry.iitd.ac.in.
authors.forename: Siddharth
authors.initials: S
authors.lastname: Pandey
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry; D011522:Protons; D011721:Pyrenes / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014364:Tryptophan / Q000737:chemistry*
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D005456:Fluorescent Dyes; D010455:Peptides; D011522:Protons; D011721:Pyrenes; C495809:bispidine; D014364:Tryptophan; C030984:pyrene