title: A small synthetic molecule functions as a chloride-bicarbonate dual-transporter and induces chloride secretion in cells.
abstract: A C2 symmetric small molecule composed of l-phenylalanine and isophthalamide was found to function as a Cl(-)/HCO3(-) dual transporter and self-assemble into chloride channels. In Ussing-chamber based short-circuit current measurements, this molecule elicited chloride-dependent short-circuit current (Isc) increase in both Calu-3 cell and CFBE41o-cell (with F508del mutant CFTR) monolayers.
authors.affiliation: Morningside Laboratory for Chemical Biology, Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. yangdan@hku.hk.
authors.forename: Peng-Yun
authors.initials: PY
authors.lastname: Liu
authors.affiliation: Morningside Laboratory for Chemical Biology, Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. yangdan@hku.hk.
authors.forename: Shing-To
authors.initials: ST
authors.lastname: Li
authors.affiliation: Morningside Laboratory for Chemical Biology, Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. yangdan@hku.hk.
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Shen
authors.affiliation: School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, P. R. China. whko@cuhk.edu.hk yao2068@cuhk.edu.hk.
authors.forename: Wing-Hung
authors.initials: WH
authors.lastname: Ko
authors.affiliation: School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, P. R. China. whko@cuhk.edu.hk yao2068@cuhk.edu.hk.
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Yao
authors.affiliation: Morningside Laboratory for Chemical Biology, Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. yangdan@hku.hk.
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
mesh_terms: D001639:Bicarbonates / Q000378:metabolism*; D001692:Biological Transport; D002478:Cells, Cultured; D018118:Chloride Channels / Q000737:chemistry*; D002712:Chlorides / Q000378:metabolism*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009154:Mutation
chemical_list: D001639:Bicarbonates; C505032:CFTR protein, human; D018118:Chloride Channels; D002712:Chlorides; D019005:Cystic Fibrosis Transmembrane Conductance Regulator