title: Liposome production by microfluidics: potential and limiting factors.
abstract: This paper provides an analysis of microfluidic techniques for the production of nanoscale lipid-based vesicular systems. In particular we focus on the key issues associated with the microfluidic production of liposomes. These include, but are not limited to, the role of lipid formulation, lipid concentration, residual amount of solvent, production method (including microchannel architecture), and drug loading in determining liposome characteristics. Furthermore, we propose microfluidic architectures for the mass production of liposomes with a view to potential industrial translation of this technology.
authors.affiliation: Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, University of Oxford, Oxford, United Kingdom.|Mechatronics and Bioengineering Science research groups, Faculty of Engineering and the Environment, University of Southampton, Southampton, United Kingdom.
authors.forename: Dario
authors.initials: D
authors.lastname: Carugo
authors.affiliation: Department of Life Science and Biotechnology, University of Ferrara, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Bottaro
authors.affiliation: Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, University of Oxford, Oxford, United Kingdom.
authors.forename: Joshua
authors.initials: J
authors.lastname: Owen
authors.affiliation: Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, University of Oxford, Oxford, United Kingdom.
authors.forename: Eleanor
authors.initials: E
authors.lastname: Stride
authors.affiliation: Department of Life Science and Biotechnology, University of Ferrara, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Nastruzzi
mesh_terms: D016503:Drug Delivery Systems; D008081:Liposomes / Q000378:metabolism*; D044085:Microfluidics / Q000379:methods*; D010316:Particle Size; D012997:Solvents
chemical_list: D008081:Liposomes; D012997:Solvents