title: Synthesis and characterization of Zinc (II)-loaded Zeolite/Graphene oxide nanocomposite as a new drug carrier.
abstract: Current research has focused on the preparation of Zinc-clinoptilolite/Graphene Oxide (Zn-Clin/GO) hybrid nanostructure and investigating its biocompatibility for the first time. As prepared samples were characterized by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Thermo gravimetric analysis (TGA) and Fourier transform infrared (FT-IR). In order to use it as a drug carrier two important factors were investigated: cytocompatibility of nanocomposites and their drug loading capacity. The results showed that the prepared nanocomposite is cytocompatible and its high loading capacity and slow release performance for Doxorubicin (DOX), as a cancer drug, proved that it can be used as a drug carrier. At last in-vitro toxicity of DOX loaded nanocomposite was compared with pure DOX.
authors.affiliation: Inorganic Chemistry Department, Faculty of Chemistry, University of Tabriz, C.P. 51664 Tabriz, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Khatamian
authors.affiliation: Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran; Inorganic Chemistry Department, Faculty of Chemistry, University of Tabriz, C.P. 51664 Tabriz, Iran. Electronic address: baharakdivband@yahoo.com.
authors.forename: B
authors.initials: B
authors.lastname: Divband
authors.affiliation: Inorganic Chemistry Department, Faculty of Chemistry, University of Tabriz, C.P. 51664 Tabriz, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Farahmand-Zahed
mesh_terms: D000072283:A549 Cells; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry* / Q000633:toxicity; D010087:Oxides / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction; D017641:Zeolites / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D010087:Oxides; D017641:Zeolites; D006108:Graphite; D004317:Doxorubicin; D015032:Zinc
keywords: Biocompatibility; Clinoptilolite; Doxorubicin; Drug carrier system; In vitro cytotoxicity