title: Herpes Simplex Virus Type 2 Seroprevalence and Ultrasound-Diagnosed Uterine Fibroids in a Large Population of Young African-American Women.
abstract: For decades reproductive tract infections (RTIs) have been hypothesized to play a role in uterine fibroid development. The few previous studies conducted used self-reported history of RTIs and had inconsistent findings. We investigated this hypothesis further using serological analysis, an immunological measure of past exposure. We focused on herpes simplex virus type 2 (HSV-2) because prior published data have suggested a possible association with fibroids, and serology for HSV-2 is much more sensitive than self-report. We used cross-sectional enrollment data from African-American women enrolled in a prospective study of fibroid incidence and growth (recruited 2010-2012) in the Detroit, Michigan, area. The women were aged 23-34 years and were screened for fibroids using a standardized ultrasound examination at their enrollment. Age- and multivariable-adjusted logistic regression models were used to estimate odds ratios. Of 1,696 participants, 1,658 had blood samples and HSV-2 serology results; 22% of participants with serology results had fibroids. There was no significant association between HSV-2 seropositivity and the presence of fibroids (multivariable-adjusted odds ratio = 0.94, 95% confidence interval: 0.73, 1.20), nor were there any associations with size of the largest fibroid, number of fibroids, or total fibroid volume. Our data provide no evidence for an influence of HSV-2 exposure on fibroid risk in young African-American women. Further study of other serologically measured RTIs is warranted.
authors.forename: Kristen R
authors.initials: KR
authors.lastname: Moore
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Smith
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Cole
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Schoenbach
authors.forename: Katherine
authors.initials: K
authors.lastname: Schlusser
authors.forename: Charlotte A
authors.initials: CA
authors.lastname: Gaydos
authors.forename: Donna D
authors.initials: DD
authors.lastname: Baird
mesh_terms: D000328:Adult; D001741:Black or African American; D000428:Alcohol Drinking / Q000208:ethnology; D000914:Antibodies, Viral / Q000097:blood; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006561:Herpes Simplex / Q000208:ethnology*; D018258:Herpesvirus 2, Human; D006801:Humans; D007889:Leiomyoma / Q000000981:diagnostic imaging / Q000208:ethnology*; D008824:Michigan / Q000453:epidemiology; D016017:Odds Ratio; D011446:Prospective Studies; D015203:Reproducibility of Results; D016036:Seroepidemiologic Studies; D012725:Sexual Behavior / Q000208:ethnology
chemical_list: D000914:Antibodies, Viral
keywords: herpes simplex virus type 2; seroprevalence; uterine fibroids