title: High Plasma Pentraxin 3 Levels in Diabetic Polyneuropathy Patients with Nociceptive Pain.
abstract: Diabetic polyneuropathy is the most common neurologic complication of diabetes mellitus. Underlying mechanisms of diabetic polyneuropathy are related to various metabolic and inflammatory pathways. Pentraxin 3 (PTX3) is an acute phase protein that is produced locally at the inflammatory sites by several cell types. Thioredoxin binding protein 2 (TBP2) is a thioredoxin regulator involved in intracellular energy pathways and cell growth. We measured the plasma levels of PTX3 and TBP2 in type 2 diabetic patients (n = 27) with pain complaints and compared their levels with those of healthy age- and sex-matched subjects (n = 24). Moreover, the diabetic patients were divided into two groups using the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) pain scale: patients with nociceptive pain that is caused by tissue damage and patients with neuropathic pain that is caused by nerve damage. Patients with LANSS scores of < 12 were considered to have nocicceptive pain (n = 15), while patients with LANSS scores of ≥ 12 were considered to have neuropathic pain (n = 12). We found that PTX3 levels were significantly higher in diabetic patients compared to controls (p = 0.03), but there was no significant difference in the TBP2 levels. Importantly, patients with nociceptive pain had significantly higher PTX3 levels compared to patients with neuropathic pain (p < 0.05). Thus, plasma PTX3 levels can be helpful for discrimination of nociceptive pain from neuropathic pain in diabetic patients. We propose that PTX3 may contribute to the onset of nociceptive pain.
authors.affiliation: Department of Neurology, Uskudar University, NPIstanbul Neuropsychiatry Hospital.
authors.forename: Celal
authors.initials: C
authors.lastname: Salcini
authors.forename: Belkis
authors.initials: B
authors.lastname: Atasever-Arslan
authors.forename: Gulin
authors.initials: G
authors.lastname: Sunter
authors.forename: Hazal
authors.initials: H
authors.lastname: Gur
authors.forename: Fatma Busra
authors.initials: FB
authors.lastname: Isik
authors.forename: Cemil Can
authors.initials: CC
authors.lastname: Saylan
authors.forename: Ayse Destina
authors.initials: AD
authors.lastname: Yalcin
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003929:Diabetic Neuropathies / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D059226:Nociceptive Pain / Q000097:blood* / Q000503:physiopathology; D010147:Pain Measurement; D000683:Serum Amyloid P-Component / Q000032:analysis* / Q000378:metabolism; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins