title: Transcription factor Oct-1 stimulates the release of Mts1/S100A4 protein by the cancer cells.
abstract: The effect of the transcription factor Oct-1 (POU2F1) on the expression of the tumor cell marker metastasin (Mts1/S100A4) was studied. Comparative analysis of various tumor lines showed no clear correlation between the expression level of Mts1/S100A4 and the content of Oct-1. However, at stable transfection of tumor cells with Oct-1A, Oct-1L, and Oct-1X isoforms we detected an elevated level of Oct-1, which stimulated Mts1/S100A4 secretion. These findings extend our understanding of the molecular mechanisms of the tumorigenic effect of Oct-1.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia. tanjnij86@mail.ru.
authors.forename: T N
authors.initials: TN
authors.lastname: Portseva
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Brechalov
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Dukhanina
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Stepchenko
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Pankratova
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia.
authors.forename: S G
authors.initials: SG
authors.lastname: Georgieva
mesh_terms: D026481:Blotting, Far-Western; D045744:Cell Line, Tumor; D003470:Culture Media; D005260:Female; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D050811:Octamer Transcription Factor-1 / Q000378:metabolism*; D020033:Protein Isoforms; D000071999:S100 Calcium-Binding Protein A4 / Q000378:metabolism*
chemical_list: D003470:Culture Media; D050811:Octamer Transcription Factor-1; C494165:POU2F1 protein, human; D020033:Protein Isoforms; D000071999:S100 Calcium-Binding Protein A4; C077591:S100A4 protein, human