title: Effects of hypervolemia by protein and glucose supplementation during aerobic training on thermal and arterial pressure regulations in hypertensive older men.
abstract: In Japan, the incidence of heat illness in older people has rapidly increased during midsummer in the last decade, and we suggested that whey-protein+carbohydrate supplementation during aerobic training would increased plasma volume (PV) to enhance thermoregulatory adaptation in older men (J Appl Physiol 107: 725-733, 2009); however, >60% of people age 65 and older suffer from hypertension, and the symptoms may be worsened by hypervolemia. To examine this, we randomly divided 21 older men (∼69 yr) with ∼160 mmHg for systolic and ∼90 mmHg for diastolic blood pressure at rest into two groups: Glc (n = 11) consuming glucose alone (25 g) and Pro-Glc (n = 10) consuming whey protein (10 g) + glucose (15 g), immediately after cycling exercise at 60-75% of peak aerobic capacity (V̇o2 peak) for 60 min/day, 3 days/wk, for 8 wk. Before and after training, we measured PV (dye dilution), baroreflex sensitivity (BRS) of heart rate (Valsalva maneuver), and carotid arterial compliance (CAC) from carotid arterial diameter (ultrasound imaging) responses to pulsatile arterial pressure change (photoplethysmography) at rest. Additionally, we measured esophageal temperature (Tes) and forearm skin blood flow (plethysmography) during exercise at 60% pretraining V̇o2 peakfor 20 min in a warm environment. We found that the forearm skin vascular conductance response to increased Teswas enhanced in Pro-Glc with increased PV, but this was not found in Glc; however, despite the increased PV, arterial blood pressures rather decreased with increased CAC and BRS in Pro-Glc. Thus, the prescription was applicable to older men with hypertension to prevent heat illness during exercise.
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto Japan.
authors.forename: Yufuko
authors.initials: Y
authors.lastname: Kataoka
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto Japan.|Institute for Biomedical Sciences, Shinshu University, Matsumoto Japan.
authors.forename: Yoshi-Ichiro
authors.initials: YI
authors.lastname: Kamijo
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Ogawa
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Sumiyoshi
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Nakae
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Ikegawa
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Manabe
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto Japan.|Institute for Biomedical Sciences, Shinshu University, Matsumoto Japan.|Jukunentaiikudaigaku Research Center, Matsumoto Japan; and.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Morikawa
authors.affiliation: Food Science Research Laboratories, Meiji Company, Odawara, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Nagata
authors.affiliation: Food Science Research Laboratories, Meiji Company, Odawara, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takasugi
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto Japan.|Institute for Biomedical Sciences, Shinshu University, Matsumoto Japan.
authors.forename: Shizue
authors.initials: S
authors.lastname: Masuki
authors.affiliation: Department of Sports Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto Japan; nosehir@shinshu-u.ac.jp.|Institute for Biomedical Sciences, Shinshu University, Matsumoto Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nose
mesh_terms: D000284:Administration, Oral; D000368:Aged; D062186:Arterial Pressure / Q000187:drug effects*; D017704:Baroreflex / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D004044:Dietary Proteins / Q000008:administration & dosage*; D019587:Dietary Supplements; D005081:Exercise Therapy / Q000379:methods*; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D010953:Plasma Volume / Q000187:drug effects*
chemical_list: D004044:Dietary Proteins; D005947:Glucose
keywords: aerobic training; hypertension; older men; supplement; thermoregulation