title: The potential role of epigenetic modulations in BPPV maneuver exercises.
abstract: Benign paroxysmal positional vertigo (BPPV) is one of the most common complaints encountered in clinics and is strongly correlated with advanced age or, possibly, degeneration. Redistribution exercises are the most effective approaches to treat BPPV, and canalith repositioning procedure (CRP) cure most BPPV cases. However, the mechanisms through which the treatment modulates systemic molecules in BPPV patients remain largely unknown. In this study, we report that the miR-34a and Sirtuin 1 (SIRT1) genes correlated with the treatment effects of CRP in BPPV subjects. We found that miR-34a expression was largely inhibited and SIRT1 expression was significantly reversed after BPPV maneuver treatment. We also confirmed that the PPAR-γ, PGC-1 and FoxO gene expressions were decreased immediately after canalith repositioning procedure (CRP) for BPPV, and were largely increased after a complete cure of BPPV. Moreover, we observed that after a complete recovery of BPPV, the ROS concentrations, pro-inflammatory cytokine concentrations and p53 expression levels were attenuated. We conclude that BPPV treatment might involve some epigenetic regulations through the mediation of miR-34a, SIRT1 functions and repression of redox status.
authors.affiliation: Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Kun-Ling
authors.initials: KL
authors.lastname: Tsai
authors.affiliation: Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital; Taipei, Taiwan.|Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Chia-To
authors.initials: CT
authors.lastname: Wang
authors.affiliation: Department of Sports Sciences, University of Taipei, Taipei, Taiwan.
authors.forename: Chia-Hua
authors.initials: CH
authors.lastname: Kuo
authors.affiliation: Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Department of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital, Taichung, Taiwan.|Department of Physical Medicine and Rehabilitation, School of Medicine National Yang-Ming University, Taipei, Taiwan.
authors.forename: Yuan-Yang
authors.initials: YY
authors.lastname: Cheng
authors.affiliation: Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Hsin-I
authors.initials: HI
authors.lastname: Ma
authors.affiliation: Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Ching-Hsia
authors.initials: CH
authors.lastname: Hung
authors.affiliation: Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Yi-Ju
authors.initials: YJ
authors.lastname: Tsai
authors.affiliation: Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital; Taipei, Taiwan.|Department of Physical Medicine and Rehabilitation, School of Medicine National Yang-Ming University, Taipei, Taiwan.
authors.forename: Chung-Lan
authors.initials: CL
authors.lastname: Kao
mesh_terms: D000367:Age Factors; D000368:Aged; D065635:Benign Paroxysmal Positional Vertigo / Q000097:blood / Q000235:genetics* / Q000628:therapy*; D016207:Cytokines / Q000378:metabolism; D044127:Epigenesis, Genetic; D005081:Exercise Therapy; D000071161:Forkhead Box Protein O1 / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D010037:Otolithic Membrane / Q000503:physiopathology; D047495:PPAR gamma / Q000378:metabolism; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D012665:Semicircular Canals / Q000503:physiopathology; D056564:Sirtuin 1 / Q000378:metabolism*; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D016207:Cytokines; C085126:FOXO1 protein, human; D000071161:Forkhead Box Protein O1; C522425:MIRN34 microRNA, human; D035683:MicroRNAs; D047495:PPAR gamma; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D017382:Reactive Oxygen Species; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Gerotarget; Sirtuin 1; benign paroxysmal positional vertigo; maneuver exercises; microRNA