title: Adult Born Olfactory Bulb Dopaminergic Interneurons: Molecular Determinants and Experience-Dependent Plasticity.
abstract: The olfactory bulb (OB) is a highly plastic brain region involved in the early processing of olfactory information. A remarkably feature of the OB circuits in rodents is the constitutive integration of new neurons that takes place during adulthood. Newborn cells in the adult OB are mostly inhibitory interneurons belonging to chemically, morphologically and functionally heterogeneous types. Although there is general agreement that adult neurogenesis in the OB plays a key role in sensory information processing and olfaction-related plasticity, the contribution of each interneuron subtype to such functions is far to be elucidated. Here, we focus on the dopaminergic (DA) interneurons: we highlight recent findings about their morphological features and then describe the molecular factors required for the specification/differentiation and maintenance of the DA phenotype in adult born neurons. We also discuss dynamic changes of the DA interneuron population related to age, environmental stimuli and lesions, and their possible functional implications.
authors.affiliation: Department of Life Sciences and Systems Biology, University of TurinTorino, Italy; Neuroscience Institute Cavalieri Ottolenghi, University of TurinOrbassano, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Bonzano
authors.affiliation: Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia Genova, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Bovetti
authors.affiliation: Department of Life Sciences and Systems Biology, University of Turin Torino, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Gendusa
authors.affiliation: Department of Life Sciences and Systems Biology, University of TurinTorino, Italy; Neuroscience Institute Cavalieri Ottolenghi, University of TurinOrbassano, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Peretto
authors.affiliation: Department of Life Sciences and Systems Biology, University of TurinTorino, Italy; Neuroscience Institute Cavalieri Ottolenghi, University of TurinOrbassano, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: De Marchis
keywords: COUP-TFI; adult neurogenesis; dopaminergic neurons; juxtaglomerular neurons; odor deprivation; odor enrichment; olfactory bulb; tyrosine hydroxylase