title: Cocktail Therapy of 177Lu-PSMA-617 and 177Lu-EDTMP in Patients With mCRPC: A Proof-of-Principle Application.
abstract: Prostate cancer is the second most common primary tumor affecting men worldwide. Among them, 10-20% develop castration resistant prostate cancer (CRPC). Ga-PSMA-PET/CT is an important theranostic agent for the evaluation of CRPC to assess the feasibility of treatment with Lu-PSMA-617 which is a novel therapeutic agent. Interestingly, in certain cases, we have observed non-PSMA-avid lesions despite raised sPSA levels. In this regard, we present a case of cocktail therapy applied using Lu-PSMA-617 and Lu-EDTMP therapy in a 38-year-old male CRPC patient with both soft tissue and extensive skeletal metastases.
authors.affiliation: From the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Chandrasekhar
authors.initials: C
authors.lastname: Bal
authors.forename: Madhav Prasad
authors.initials: MP
authors.lastname: Yadav
authors.forename: Sanjana
authors.initials: S
authors.lastname: Ballal
mesh_terms: D000328:Adult; D004151:Dipeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D004492:Edetic Acid / Q000031:analogs & derivatives; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006573:Heterocyclic Compounds, 1-Ring / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009842:Oligopeptides; D009942:Organometallic Compounds / Q000627:therapeutic use*; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D000072078:Positron Emission Tomography Computed Tomography; D017430:Prostate-Specific Antigen; D064129:Prostatic Neoplasms, Castration-Resistant / Q000000981:diagnostic imaging / Q000188:drug therapy*; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D004151:Dipeptides; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006573:Heterocyclic Compounds, 1-Ring; D009842:Oligopeptides; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; C000602389:PSMA-617; D019275:Radiopharmaceuticals; C000718244:gallium 68 PSMA-11; C119503:lutetium ethylenediaminetetramethylene phosphonic acid; D004492:Edetic Acid; D017430:Prostate-Specific Antigen