title: Atypical Inflammasomes.
abstract: Pattern recognition receptors, including members of the NLR and PYHIN families, are essential for recognition of both pathogen- and host-derived danger signals. A number of molecules in these families are capable of forming multiprotein complexes termed inflammasomes that result in the activation of caspase-1. In addition to NLRP1, NLRP3, NLRC4, and AIM2, which form well-described inflammasome complexes, IFI16, NLRP6, NLRP7, NLRP12, and NLRC5 have also been proposed to form inflammasomes under specific conditions. The structure and function of these atypical inflammasomes will be highlighted here.
authors.affiliation: Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Janowski
authors.affiliation: Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, USA. fayyaz-sutterwala@uiowa.edu.|Inflammation Program, Department of Internal Medicine, University of Iowa Carver College of Medicine, 2501 Crosspark Road, D156 MTF, Iowa City, IA, 52241, USA. fayyaz-sutterwala@uiowa.edu.|Veterans Affairs Medical Center, Iowa City, IA, USA. fayyaz-sutterwala@uiowa.edu.
authors.forename: Fayyaz S
authors.initials: FS
authors.lastname: Sutterwala
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000737:chemistry* / Q000378:metabolism; D051192:Receptors, Pattern Recognition / Q000378:metabolism*
chemical_list: D058847:Inflammasomes; D051192:Receptors, Pattern Recognition
keywords: Caspase-1; Inflammasome; NLR