title: Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty.
abstract: Girls with precocious puberty have high luteinizing hormone (LH) levels and advanced bone age. Obese children enter puberty at earlier ages than do non-obese children. We analyzed the effects of obesity on LH secretion during gonadotropin-releasing hormone (GnRH) tests in girls with precocious puberty.
  
  
  
  A total of 981 subjects with idiopathic precocious puberty who had undergone a GnRH stimulation testing between 2008 and 2014 were included in the study. Subjects were divided into three groups based on body mass index (BMI). Auxological data and gonadotropin levels after the GnRH stimulation test were compared.
  
  
  
  In Tanner stage 2 girls, peak stimulated LH levels on GnRH test were 11.9±7.5, 10.4±6.4, and 9.1±6.1 IU/L among normal-weight, overweight, and obese subjects, respectively (p=0.035 for all comparisons). In Tanner stage 3 girls, peak stimulated LH levels were 14.9±10.9, 12.8±7.9, and 9.6±6.0 IU/L, respectively (p=0.022 for all comparisons). However, in Tanner stage 4 girls, peak stimulated LH levels were not significantly different among normal, overweight, and obese children. On multivariate analysis, BMI standard deviation score was significantly and negatively associated with peak LH (β=-1.178, p=0.001).
  
  
  
  In girls with central precocious puberty, increased BMI was associated with slightly lower peak stimulated LH levels at early pubertal stages (Tanner stages 2 and 3). This association was not valid in Tanner stage 4 girls.
authors.forename: Hae Sang
authors.initials: HS
authors.lastname: Lee
authors.forename: Jong Seo
authors.initials: JS
authors.lastname: Yoon
authors.affiliation: Ajou University School of Medicine, Ajou University Hospital, Department of Pediatrics, Suwon, Korea, Phone: 82-31-219-5166 E-mail: pedhwang@ajou.ac.kr.
authors.forename: Jin Soon
authors.initials: JS
authors.lastname: Hwang
mesh_terms: D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D003940:Diagnostic Techniques, Endocrine; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood* / Q000378:metabolism; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood* / Q000378:metabolism; D050177:Overweight; D011629:Puberty, Precocious / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism; D013997:Time Factors
chemical_list: D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone