title: Association between IL-6 Gene (-174 & -572 G/C) Polymorphisms and Endometrial Adenocarcinoma Risk.
abstract: We aimed to evaluate the association of IL-6 gene polymorphisms at positions of -174 and -572 and predisposition of endometrial adenocarcinoma (EAC) in a Chinese population. EAC patients have remarkably higher frequency of IL-6 -174 CC genotype [odds ratio (OR) =1.56, 95 % confidence interval (CI) =1.07-2.23; P = 0.03], IL-6 -572 CC genotype (OR =1.93, 95%CI =1.17-3.15; P = 0.01) and IL-6 -174 C allele (OR =1.22, 95 % CI =1.03-1.46; P = 0.04) compared with healthy controls. When stratified with FIGO stage, patients with III-IV EAC have a significantly higher frequency of IL-6 -174 CC genotype (OR =1.66, 95% CI =1.06-2.58; P = 0.02) than healthy controls. The CC genotype of IL-6 gene polymorphisms at positions of -174 and -572 may denote potential high risk of EAC.
authors.affiliation: Department of laboratory medicine, Henan Province Chinese Medicine Hospital, Zhenzhou, 450002, People's Republic of China.
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Wang
authors.affiliation: Department of laboratory medicine, Henan Province Chinese Medicine Hospital, Zhenzhou, 450002, People's Republic of China.
authors.forename: Jin-Jun
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: Department of laboratory medicine, Henan Province Chinese Medicine Hospital, Zhenzhou, 450002, People's Republic of China.
authors.forename: Xiang-Yu
authors.initials: XY
authors.lastname: Zheng
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai Ninth People's Hospital & School of Medicine, Shanghai Jiaotong University, Shanghai, 200011, People's Republic of China. LIUJianh68@126.com.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Liu
authors.affiliation: Department of laboratory medicine, Henan Province Chinese Medicine Hospital, Zhenzhou, 450002, People's Republic of China. liyw71@126.com.
authors.forename: Yong-Wei
authors.initials: YW
authors.lastname: Li
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6
keywords: Endometrial adenocarcinoma; Gene polymorphism; Interleukin-6