title: Ridge preservation of extraction sockets with chronic pathology using Bio-Oss®Collagen with or without collagen membrane: an experimental study in dogs.
abstract: OBJECTIVE
  This study aimed to evaluate the dynamics of newly bone formation and dimensional change in diseased extraction sockets using Bio-Oss®Collagen with or without a collagen membrane.
  
  
  METHODS
  In six beagle dogs, right and left 3rd and 4th mandibular premolars were hemisected and the distal roots were removed. Combined endodontic-periodontic lesions were induced in all sites using black silk, collagen sponge, endodontic files, and application of Porphyromonas gingivalis. After 4 months, among 4 premolars, three teeth were randomly selected per dog and allocated to the following experimental groups: Control group (no treatment but debridement), Test 1 group (only Bio-Oss®Collagen graft), and Test 2 group (Bio-Oss®Collagen graft with a collagen membrane). After 7 months from the baseline, the beagle dogs were sacrificed for histomorphometric and Micro-CT analysis.
  
  
  RESULTS
  The vertical distance between buccal and lingual crests in the Control group (2.22 ± 0.26 mm) and Test 2 group (1.80 ± 0.16 mm) was significantly different. The socket of the Test 2 group (27.04 ± 5.25%) was occupied by a greater quantity of bone graft compared to the Test 1 group (18.49 ± 2.11%).
  
  
  CONCLUSIONS
  Ridge preservation in diseased extraction sockets could compensate for buccal bone resorption by contact osteogenesis surrounding the bone graft particles at the bucco-coronal area during socket healing, and the application of a collagen membrane at the entrance of the socket is useful for preserving graft material at the coronal part of the socket.
authors.affiliation: Department of Periodontology and Dental Research Institute, Translational Research Laboratory for Tissue Engineering (TTE), School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Jung-Ju
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: Department of Oral Surgery, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Schwarz
authors.affiliation: Department of Periodontology and Dental Research Institute, Translational Research Laboratory for Tissue Engineering (TTE), School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Song
authors.affiliation: Geistlich Pharma Korea, Seoul, Korea.
authors.forename: YoonMi
authors.initials: Y
authors.lastname: Choi
authors.affiliation: Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Kyung-Rim
authors.initials: KR
authors.lastname: Kang
authors.affiliation: Department of Periodontology and Dental Research Institute, Translational Research Laboratory for Tissue Engineering (TTE), School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Ki-Tae
authors.initials: KT
authors.lastname: Koo
mesh_terms: D000818:Animals; D016866:Bacteroidaceae Infections / Q000503:physiopathology*; D001861:Bone Regeneration; D018786:Bone Substitutes; D002908:Chronic Disease; D003094:Collagen; D004195:Disease Models, Animal; D004285:Dogs; D007249:Inflammation; D008567:Membranes, Artificial; D008903:Minerals; D016966:Porphyromonas gingivalis; D014081:Tooth Extraction; D020390:Tooth Socket / Q000166:cytology / Q000000981:diagnostic imaging / Q000382:microbiology / Q000502:physiology*; D014945:Wound Healing; D055114:X-Ray Microtomography
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen
keywords: Bio-Gide; Bio-Oss; chronic disease; osteogenesis; socket graft; tooth socket