title: Relationship between betatrophin levels and metabolic parameters in patients with polycystic ovary syndrome.
abstract: To evaluate the status of serum betatrophin levels and potential relations between metabolic parameters and betatrophin levels in patients with polycystic ovary syndrome. We included patients newly diagnosed with PCOS in our study. Fifty-seven female patients (30 patients with PCOS and 27 healthy control subjects) were enrolled in this study. Serum betatrophin levels were measured using a betatrophin enzyme-linked immunosorbent assay kit. Insulin resistance was calculated using the homeostasis model of the assessment-insulin resistance index formula. The betatrophin level was 1538,85 ng/L in the patient group and 2440,46 ng/L in the control group, and the difference was statistically significant (p=0.003). A significantly negative correlation was found between betatrophin level and insulin, HOMA-IR, and BMI. Betatrophin levels in patients with PCOS are lower than those without PCOS and inversely related to insulin resistance.
authors.affiliation: Canakkale Onsekiz Mart University School of Medicine Department of General Medicine Canakkale Turkey gokhanerbag@hotmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Erbag
authors.affiliation: Canakkale Onsekiz Mart University School of Medicine Department of Endocrinology and Metabolism Canakkale Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Eroglu
authors.affiliation: Canakkale Onsekiz Mart University School of Medicine Department of Clinical Biochemistry Canakkale Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Turkon
authors.affiliation: Canakkale Onsekiz Mart University School of Medicine Department of General Medicine Canakkale Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Sen
authors.affiliation: Canakkale Onsekiz Mart University School of Medicine Department of General Medicine Canakkale Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Binnetoglu
authors.affiliation: Canakkale Onsekiz Mart University School of Medicine Department of Radiology Canakkale Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Aylanc
authors.affiliation: Canakkale Onsekiz Mart University School of Medicine Department of Endocrinology and Metabolism Canakkale Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Asik
mesh_terms: D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D006801:Humans; D036361:Peptide Hormones / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000378:metabolism*; D012044:Regression Analysis; D055815:Young Adult
chemical_list: C576683:ANGPTL8 protein, human; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D036361:Peptide Hormones