title: Insights into the role of neuronal glucokinase.
abstract: Glucokinase is a key component of the neuronal glucose-sensing mechanism and is expressed in brain regions that control a range of homeostatic processes. In this review, we detail recently identified roles for neuronal glucokinase in glucose homeostasis and counterregulatory responses to hypoglycemia and in regulating appetite. We describe clinical implications from these advances in our knowledge, especially for developing novel treatments for diabetes and obesity. Further research required to extend our knowledge and help our efforts to tackle the diabetes and obesity epidemics is suggested.
authors.affiliation: Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, United Kingdom.
authors.forename: Ivan
authors.initials: I
authors.lastname: De Backer
authors.affiliation: Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, United Kingdom.
authors.forename: Sufyan S
authors.initials: SS
authors.lastname: Hussain
authors.affiliation: Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, United Kingdom s.bloom@imperial.ac.uk.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Bloom
authors.affiliation: Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, United Kingdom.
authors.forename: James V
authors.initials: JV
authors.lastname: Gardiner
mesh_terms: D000818:Animals; D001066:Appetite / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism*; D005941:Glucokinase / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007003:Hypoglycemia / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*
chemical_list: D005941:Glucokinase; D005947:Glucose
keywords: appetite; counterregulatory response; glucokinase; glucose homeostasis; glucose sensing; neuronal