title: Development of a primary cutaneous CD30(+) anaplastic large-cell T-cell lymphoma during treatment of multiple sclerosis with fingolimod.
abstract: The appearance of solid tumors und lymphomas during treatment with fingolimod was observed in studies and has been described in case reports.
  
  
  
  To report a case of primary cutaneous CD30(+) anaplastic large-cell T-cell lymphoma during treatment of multiple sclerosis (MS) with fingolimod.
  
  
  
  Case study.
  
  
  
  Our patient developed a lymphoma a few weeks after initialization of therapy with fingolimod; 5 weeks after discontinuation of treatment the lesions resolved.
  
  
  
  Causality of fingolimod is indicated by the fact that the skin lesions appeared after commencement of treatment and resolved after discontinuation of therapy. This case serves as a reminder of the potential side effects of fingolimod.
authors.affiliation: Department of Dermatology and Venereology, Harzklinikum Dorothea Christiane Erxleben, Quedlinburg, Germany dpapathem@live.com.
authors.forename: Despoina
authors.initials: D
authors.lastname: Papathemeli
authors.affiliation: Department of Dermatology and Venereology, Harzklinikum Dorothea Christiane Erxleben, Quedlinburg, Germany.
authors.forename: Ronald
authors.initials: R
authors.lastname: Gräfe
authors.affiliation: Department of Pathology, Harzklinikum Dorothea Christiane Erxleben, Quedlinburg, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Hildebrandt
authors.affiliation: Department of Neurology, University of Rostock, Rostock, Germany.
authors.forename: Uwe K
authors.initials: UK
authors.lastname: Zettl
authors.affiliation: Department of Dermatology and Venereology, Harzklinikum Dorothea Christiane Erxleben, Quedlinburg, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Ulrich
mesh_terms: D005260:Female; D000068876:Fingolimod Hydrochloride / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D017730:Ki-1 Antigen; D017728:Lymphoma, Large-Cell, Anaplastic / Q000139:chemically induced*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000139:chemically induced*
chemical_list: D007166:Immunosuppressive Agents; D017730:Ki-1 Antigen; D000068876:Fingolimod Hydrochloride
keywords: Fingolimod; adverse side effects; lymphoma; multiple sclerosis; primary cutaneous CD30(+) anaplastic large-cell T-cell lymphoma; skin