title: Biomimetic fiber mesh scaffolds based on gelatin and hydroxyapatite nano-rods: Designing intrinsic skills to attain bone reparation abilities.
abstract: Intrinsic material skills have a deep effect on the mechanical and biological performance of bone substitutes, as well as on its associated biodegradation properties. In this work we have manipulated the preparation of collagenous derived fiber mesh frameworks to display a specific composition, morphology, open macroporosity, surface roughness and permeability characteristics. Next, the effect of the induced physicochemical attributes on the scaffold's mechanical behavior, bone bonding potential and biodegradability were evaluated. It was found that the scaffold microstructure, their inherent surface roughness, and the compression strength of the gelatin scaffolds can be modulated by the effect of the cross-linking agent and, essentially, by mimicking the nano-scale size of hydroxyapatite in natural bone. A clear effect of bioactive hydroxyapatite nano-rods on the scaffolds skills can be appreciated and it is greater than the effect of the cross-linking agent, offering a huge perspective for the upcoming progress of bone implant technology.
authors.affiliation: Department of Chemistry,Universidad Nacional del Sur, INQUISUR - CONICET, 8000 Bahía Blanca, Argentina.
authors.forename: Javier
authors.initials: J
authors.lastname: Sartuqui
authors.affiliation: Department of Chemistry,Universidad Nacional del Sur, INQUISUR - CONICET, 8000 Bahía Blanca, Argentina.
authors.forename: A Noel
authors.initials: AN
authors.lastname: Gravina
authors.affiliation: Soft Matter and Molecular Biophysics Group, Department of Applied Physics, University of Santiago de Compostela, Santiago de Compostela E-15782, Spain.
authors.forename: Ramón
authors.initials: R
authors.lastname: Rial
authors.affiliation: Department of Chemistry,Universidad Nacional del Sur, INQUISUR - CONICET, 8000 Bahía Blanca, Argentina.
authors.forename: Luciano A
authors.initials: LA
authors.lastname: Benedini
authors.affiliation: Laboratory for Innovation and Analysis of Bio-Performance, École Polytechnique de Montréal, C.P. 5079, Succursale Centre-Ville Montréal, Quebec H3C 3A7, Canada.
authors.forename: L'Hocine
authors.initials: L
authors.lastname: Yahia
authors.affiliation: Soft Matter and Molecular Biophysics Group, Department of Applied Physics, University of Santiago de Compostela, Santiago de Compostela E-15782, Spain.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Ruso
authors.affiliation: Department of Chemistry,Universidad Nacional del Sur, INQUISUR - CONICET, 8000 Bahía Blanca, Argentina. Electronic address: pmessina@uns.edu.ar.
authors.forename: Paula V
authors.initials: PV
authors.lastname: Messina
mesh_terms: D032701:Biomimetics / Q000379:methods*; D017886:Durapatite / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry; D013634:Tannins / Q000737:chemistry; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D013634:Tannins; D005780:Gelatin; D017886:Durapatite
keywords: Gelatin; Hydroxyapatite; Macroporosity; Scaffolds; Tannic acid; Tissue engineering