title: High prevalence of luminal B breast cancer intrinsic subtype in Colombian women.
abstract: Breast cancer is the most frequent malignancy in women worldwide. Distinct intrinsic subtypes of breast cancer have different prognoses, and their relative prevalence varies significantly among ethnic groups. Little is known about the prevalence of breast cancer intrinsic subtypes and their association with clinicopathological data and genetic ancestry in Latin Americans. Immunohistochemistry surrogates from the 2013 St. Gallen International Expert Consensus were used to classify breast cancers in 301 patients from Colombia into intrinsic subtypes. We analyzed the distribution of subtypes by clinicopathological variables. Genetic ancestry was estimated from a panel of 80 ancestry informative markers. Luminal B breast cancer subtype was the most prevalent in our population (37.2%) followed by luminal A (26.3%), non-basal triple negative (NBTN) (11.6%), basal like (9%), human epidermal growth factor receptor 2 (HER2) enriched (8.6%) and unknown (7.3%). We found statistical significant differences in distribution between Colombian region (P = 0.007), age at diagnosis (P = 0.0139), grade (P < 0.001) and recurrence (P < 0.001) according to intrinsic subtype. Patients diagnosed with HER2-enriched, basal-like and NBTN breast cancer had the highest African ancestry. Future studies analyzing the molecular profiles of breast cancer in Colombian women will help us understand the molecular basis of this subtype distribution and compare the molecular characteristics of the different intrinsic subtypes in Colombian patients.
authors.affiliation: Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá 110411001, Colombia.|Programa de Doctorado en Ciencias Biologicas, Pontificia Universidad Javeriana, Bogota 110231, Colombia.
authors.forename: Silvia Juliana
authors.initials: SJ
authors.lastname: Serrano-Gomez
authors.affiliation: Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá 110411001, Colombia.
authors.forename: Maria Carolina
authors.initials: MC
authors.lastname: Sanabria-Salas
authors.affiliation: Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá 110411001, Colombia.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Hernández-Suarez
authors.affiliation: Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá 110411001, Colombia.
authors.forename: Oscar
authors.initials: O
authors.lastname: García
authors.affiliation: Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá 110411001, Colombia.
authors.forename: Camilo
authors.initials: C
authors.lastname: Silva
authors.affiliation: Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá 110411001, Colombia.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Romero
authors.affiliation: Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá 110411001, Colombia.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Mejía
authors.affiliation: Department of Genetics, LSUHSC, New Orleans, LA 70112, USA.|Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA 70112, USA.
authors.forename: Lucio
authors.initials: L
authors.lastname: Miele
authors.affiliation: Department of Medicine, Institute of Human Genetics, University of California San Francisco, San Francisco, CA 94158, USA and.
authors.forename: Laura
authors.initials: L
authors.lastname: Fejerman
authors.affiliation: Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA 70112, USA.|Department of Pediatrics, LSUHSC, New Orleans, LA 70112, USA.
authors.forename: Jovanny
authors.initials: J
authors.lastname: Zabaleta
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D044383:Black People / Q000235:genetics; D001943:Breast Neoplasms / Q000145:classification / Q000453:epidemiology* / Q000235:genetics; D003105:Colombia / Q000453:epidemiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000145:classification / Q000453:epidemiology* / Q000235:genetics; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics; D011960:Receptors, Estrogen / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human