title: The inflammasome: an emerging therapeutic oncotarget for cancer prevention.
abstract: Deregulated inflammation is considered to be one of the hallmarks of cancer initiation and development regulation. Emerging evidence indicates that the inflammasome plays a central role in regulating immune cells and cytokines related to cancer. The inflammasome is a multimeric complex consisting of Nod-like receptors (NLRs) and responds to a variety of endogenous (damage-associated molecular patterns) and exogenous (pathogen-associated molecular patterns) stimuli. Several lines of evidence suggests that in cancer the inflammasome is positively associated with characteristics such as elevated levels of IL-1β and IL-18, activation of NF-κB signaling, enhanced mitochondrial oxidative stress, and activation of autophagic process. A number of NLRs, such as NLRP3 and NLRC4 are also highlighted in carcinogenesis and closely correlate to chemoresponse and prognosis. Although conflicting evidence suggested the duplex role of inflammasome in cancer development, the phenomenon might be attributed to NLRs difference, cell and tissue type, cancer stage, and specific experimental conditions. Given the promising role of inflammasome in mediating cancer development, precise elucidation of its signaling network and pathological significance may lead to novel therapeutic options for malignancy therapy and prevention.
authors.affiliation: Department of Mammary Disease, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Zhiyu
authors.affiliation: Department of Breast Oncology, Sun Yat-sen Univeristy Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.
authors.forename: Neng
authors.initials: N
authors.lastname: Wang
authors.affiliation: Institute of Clinical Pharmacology, Guangzhou, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Pharmacy College, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.affiliation: College of Basic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Mammary Disease, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Pengxi
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Mammary Disease, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Ou
authors.affiliation: Department of Mammary Disease, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Shaowen
authors.initials: S
authors.lastname: Zhong
authors.affiliation: Research Laboratory, Oral Medicine Department, University of Seville, Seville, Spain.
authors.forename: Mario D
authors.initials: MD
authors.lastname: Cordero
authors.affiliation: Department of Mammary Disease, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D020170:Caspase 1 / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism*; D007249:Inflammation; D020382:Interleukin-18 / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D008024:Ligands; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000517:prevention & control*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D016896:Treatment Outcome
chemical_list: D002352:Carrier Proteins; D016207:Cytokines; D058847:Inflammasomes; D020382:Interleukin-18; D053583:Interleukin-1beta; D008024:Ligands; D016328:NF-kappa B; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D017382:Reactive Oxygen Species; D020170:Caspase 1
keywords: IL-1β/IL-18; cancer prevention; inflammasome; inflammation; nod-like receptors