title: [Efficacy of sodium hydroxide at 2.5 %, chlorhexidine gluconate at 0.5 % and calcium hydroxide against Candida albicans].
abstract: BACKGROUND
  Endodontic flora is dominated in the apical part of the channels by strict anaerobic and some facultative anaerobic bacteria but also by Candida yeasts, especially Candida albicans species that are involved in the maintenance and persistence of endodontic infections. Their elimination of the canal system in practice by chemo-mechanical methods of disinfection is not always guaranteed. Thus, this in vitro study was performed to determine the sensitivity of C. albicans with sodium hypochlorite (NaOCl) dosed at 2.5 %, the chlorhexidine digluconate 0.5 % and calcium hydroxide used in inter-session medication.
  
  
  METHODS
  The diffusion method was used initially to test the sensitivity of C. albicans strains with the above products. Then a dilution technique has allowed us to determine the minimum inhibitory concentration of these active products on C. albicans.
  
  
  RESULTS
  Strains from infected pulp teeth of patients showed a sensitivity of C. albicans to sodium hypochlorite to a minimum inhibitory concentration less than 70μg/mL and 30μg/mL for chlorhexidine.
  
  
  CONCLUSIONS
  This study demonstrated a sensitivity of C. albicans to sodium hypochlorite and chlorhexidine.
authors.affiliation: Département d'odontologie, université Cheikh Anta Diop-Dakar BP 5005 Dakar, Sénégal. Electronic address: diouma.ndiaye@ucad.edu.
authors.forename: D
authors.initials: D
authors.lastname: Ndiaye
authors.affiliation: Laboratoire de parasitologie et de mycologie, CHU Le Dantec, BP 16477, Dakar, Sénégal.
authors.forename: K
authors.initials: K
authors.lastname: Diongue
authors.affiliation: Département d'odontologie, université Cheikh Anta Diop-Dakar BP 5005 Dakar, Sénégal.
authors.forename: K
authors.initials: K
authors.lastname: Bane
authors.affiliation: Département d'odontologie, université Cheikh Anta Diop-Dakar BP 5005 Dakar, Sénégal.
authors.forename: A
authors.initials: A
authors.lastname: Seck
authors.affiliation: Département d'odontologie, université Cheikh Anta Diop-Dakar BP 5005 Dakar, Sénégal.
authors.forename: S O
authors.initials: SO
authors.lastname: Niang
authors.affiliation: Département d'odontologie, université Cheikh Anta Diop-Dakar BP 5005 Dakar, Sénégal.
authors.forename: F
authors.initials: F
authors.lastname: Lèye Benoist
authors.affiliation: Laboratoire de parasitologie et de mycologie, CHU Le Dantec, BP 16477, Dakar, Sénégal.
authors.forename: D
authors.initials: D
authors.lastname: Ndiaye
authors.affiliation: Département d'odontologie, université Cheikh Anta Diop-Dakar BP 5005 Dakar, Sénégal.
authors.forename: B
authors.initials: B
authors.lastname: Touré
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D002126:Calcium Hydroxide / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004202:Disinfectants / Q000494:pharmacology*; D004338:Drug Combinations; D006801:Humans; D008826:Microbial Sensitivity Tests; D009061:Mouth Mucosa / Q000382:microbiology; D012972:Sodium Hydroxide / Q000494:pharmacology*
chemical_list: D000891:Anti-Infective Agents, Local; D004202:Disinfectants; D004338:Drug Combinations; D012972:Sodium Hydroxide; C010882:chlorhexidine gluconate; D002126:Calcium Hydroxide; D002710:Chlorhexidine
keywords: Candida albicans; Chlorhexidine gluconate; Concentration minimale inhibitrice; Disinfection; Désinfection; Gluconate de chlorhexidine; Hypochlorite de sodium; Minimum inhibitory concentration; Sodium hypochlorite