title: Genetically diverse CC-founder mouse strains replicate the human influenza gene expression signature.
abstract: Influenza A viruses (IAV) are zoonotic pathogens that pose a major threat to human and animal health. Influenza virus disease severity is influenced by viral virulence factors as well as individual differences in host response. We analyzed gene expression changes in the blood of infected mice using a previously defined set of signature genes that was derived from changes in the blood transcriptome of IAV-infected human volunteers. We found that the human signature was reproduced well in the founder strains of the Collaborative Cross (CC) mice, thus demonstrating the relevance and importance of mouse experimental model systems for studying human influenza disease.
authors.affiliation: University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.
authors.forename: Husni
authors.initials: H
authors.lastname: Elbahesh
authors.affiliation: University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.|Department of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig,Germany.|University of Veterinary Medicine Hannover, Hannover, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Schughart
mesh_terms: D000818:Animals; D001769:Blood / Q000821:virology; D005260:Female; D018703:Founder Effect; D020869:Gene Expression Profiling / Q000379:methods*; D015967:Gene Expression Regulation, Viral; D006801:Humans; D009980:Influenza A virus / Q000145:classification / Q000235:genetics*; D007251:Influenza, Human / Q000097:blood / Q000821:virology*; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D009976:Orthomyxoviridae Infections / Q000097:blood / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D014764:Viral Proteins