title: Ultrasound-Assisted Solvent-Free Parallel Synthesis of 3-Arylcoumarins Using N-Acylbenzotriazoles.
abstract: An ultrasound-assisted one-pot acylation/cyclization reaction between N-acylbenzotriazoles and 2-hydroxybenzaldehydes has been developed for the synthesis of substituted 3-arylcoumarins. Using ultrasound not only allows rapid and clean conversion but also simplifies experimental setup and parallel workup leading to rapid generation of 3-arylcoumarin libraries under mild, solvent-free, and chromatography-free conditions.
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University , Chiang Mai 50200, Thailand.
authors.forename: Sirawit
authors.initials: S
authors.lastname: Wet-Osot
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University , Chiang Mai 50200, Thailand.
authors.forename: Chuthamat
authors.initials: C
authors.lastname: Duangkamol
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University , Chiang Mai 50200, Thailand.
authors.forename: Wong
authors.initials: W
authors.lastname: Phakhodee
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University , Chiang Mai 50200, Thailand.
authors.forename: Mookda
authors.initials: M
authors.lastname: Pattarawarapan
mesh_terms: D000215:Acylation; D003374:Coumarins / Q000138:chemical synthesis*; D003500:Cyclization; D012997:Solvents; D014230:Triazoles / Q000737:chemistry*; D014465:Ultrasonics
chemical_list: D003374:Coumarins; D012997:Solvents; D014230:Triazoles; C012771:benzotriazole
keywords: 2-hydroxybenzaldehydes; N-acylbenzotriazoles; coumarins; solvent-free; ultrasound