title: [ANALYSIS OF THE POSTOPERATIVE COURSE OF COMPLEX CONGENITAL HEART DISEASES SIMULTANEOUS CORRECTION WITH AN OPEN STERNOTOMY IN CHILDREN DURING THE FIRST MONTHS OF LIFE].
abstract: In children during the first months of life delayed sternum closure is one of the few techniques increasing cardiac output after simultaneous correction of complex congenital heart defects (CHD). The aim of study was evaluating mortality, predictors of adverse outcome and frequency noncardial complications at of delayed sternum closure after correction of CHD.
  
  
  METHODS
  Study design: a prospective, uncontrolled, cohort. 22 children were studied 6 children died. Anesthesia was carried out on the basis ofpropofol (3 mg/kg/h) and fentanyl (5 pg/kg/h) infusion with sevoflurane inhalation in a dose of 1-1.5 WT, including during perfusion. Cardiopulmonary bypass (IR) was carried out by the "Stockert S50" using oxygenators ("Medtronic"). After IR in all cases the use of arterio--venous modified ultrafiltration. Sternum closure was performed on average 2.7 ± 1.4 days after surgery.
  
  
  RESULTS
  The odds ratio (OR) of death development at the mean arterial pressure (MAP) < 35 Hg was 3.7, the OR for the risk of death development if SVO₂ < 40% was 0.94. OR for risk of death when blood lactate level > 10 mmol/l during the first three days ofpostoperative intensive care was 2.1.
  
  
  CONCLUSIONS
  The technique of delayed sternum closure is an acceptable method of maintaining cardiac output in children during the first months of life with CHD in the postoperative period. High blood lactate level (> 10 mmol/l) and especially its further growth and the MAP < 35 mm Hg can be predictors of adverse outcomes of surgical interventions with an open sternotomy.
authors.forename: I M
authors.initials: IM
authors.lastname: Habibullin
authors.forename: P I
authors.initials: PI
authors.lastname: Mironov
authors.forename: D V
authors.initials: DV
authors.lastname: Onegov
authors.forename: R I
authors.initials: RI
authors.lastname: Zaripova
authors.forename: I E
authors.initials: IE
authors.lastname: Nikolaeva
mesh_terms: D002303:Cardiac Output, Low / Q000401:mortality / Q000517:prevention & control; D006348:Cardiac Surgical Procedures / Q000379:methods* / Q000401:mortality; D015331:Cohort Studies; D006330:Heart Defects, Congenital / Q000601:surgery*; D006440:Hemofiltration; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011182:Postoperative Care / Q000379:methods*; D011183:Postoperative Complications / Q000401:mortality / Q000517:prevention & control; D011446:Prospective Studies; D012121:Respiration, Artificial; D013249:Sternum / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome