title: Vitamins A, C, and E May Reduce Intestinal 210Po Levels after Ingestion.
abstract: Damage to the gut mucosa is a probable contributory cause of death from ingested Po. Therefore, medical products are needed that can prevent, mitigate, and/or repair gastrointestinal (GI) damage caused by high-LET radiation emitted by Po. The present studies investigated the capacity of a diet highly enriched with vitamins A, C, and E (vitamin ACE) to protect against intestinal mucosal damage indicated by functional reductions in nutrient transport caused by orally ingested Po. Mice were gavaged with 0 or 18.5 kBq Po-citrate and fed a control or vitamin ACE-enriched diet (the latter beginning either 96 h before or immediately after gavage). Mouse intestines significantly retained Po on day 8 post-gavage. The concentration of Po in intestinal tissues was significantly (p<0.05) lower in all vitamin ACE groups compared to control. There were borderline significant Po-induced reductions in intestinal absorption of D-fructose. The combination of vitamins A, C, and E may reduce Po incorporation in the intestines when given before, or enhance decorporation when provided after, Po gavage.
authors.affiliation: *Department of Radiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ; †Department of Preventive Medicine and Community Health; ‡Department of Pharmacology, Physiology, and Neuroscience; §Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences Stellenbosch University, Tygerberg, South Africa.
authors.forename: Francis W
authors.initials: FW
authors.lastname: Kemp
authors.forename: Frank
authors.initials: F
authors.lastname: Portugal
authors.forename: John M
authors.initials: JM
authors.lastname: Akudugu
authors.forename: Prasad V S V
authors.initials: PV
authors.lastname: Neti
authors.forename: Ronaldo P
authors.initials: RP
authors.lastname: Ferraris
authors.forename: Roger W
authors.initials: RW
authors.lastname: Howell
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage*; D019587:Dietary Supplements; D004307:Dose-Response Relationship, Radiation; D004435:Eating / Q000502:physiology; D007408:Intestinal Absorption / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D011059:Polonium / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000379:methods; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D014801:Vitamin A / Q000008:administration & dosage*; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D011837:Radiation-Protective Agents; D014801:Vitamin A; D014810:Vitamin E; D011059:Polonium; D001205:Ascorbic Acid