title: The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis.
abstract: Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n = 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) = -0.55 pg/mL; 95% confidence interval (CI), -1.02 to -0.09], TNFα (WMD = -0.64 pg/mL; 95% CI, -1.21 to -0.06), IL8 (MD = -0.49 pg/mL; 95% CI, -0.89 to -0.09), and IL2 (WMD = 1.03 pg/mL; 95% CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD = -0.15; 95% CI, -0.56 to 0.25) or IL10 (WMD = 0.41; 95% CI, -0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population. Cancer Epidemiol Biomarkers Prev; 25(7); 1009-17. ©2016 AACR.
authors.affiliation: Norwegian Knowledge Centre for the Health Services in the Norwegian Institute of Public Health, Oslo, Norway. menesesjose77@gmail.com.
authors.forename: Jose F
authors.initials: JF
authors.lastname: Meneses-Echávez
authors.affiliation: Centro de Estudios en Medición de la Actividad Física (CEMA), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Correa-Bautista
authors.affiliation: Department of Nursing, University of Granada, Granada, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: González-Jiménez
authors.affiliation: Department of Nursing, University of Granada, Granada, Spain.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Schmidt Río-Valle
authors.affiliation: Sydney Medical School, University of Sydney, Sydney, Australia. Centre for Education and Workforce Development, Sydney Local Health District, Sydney, Australia.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Elkins
authors.affiliation: Hubert Department of Global Health, Emory University, Rollins School of Public Health, Atlanta, Georgia. Exercise is Medicine Global Research and Collaboration Center, Atlanta, Georgia.
authors.forename: Felipe
authors.initials: F
authors.lastname: Lobelo
authors.affiliation: Centro de Estudios en Medición de la Actividad Física (CEMA), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
authors.forename: Robinson
authors.initials: R
authors.lastname: Ramírez-Vélez
mesh_terms: D001943:Breast Neoplasms / Q000097:blood* / Q000401:mortality / Q000628:therapy; D002097:C-Reactive Protein / Q000032:analysis; D000073116:Cancer Survivors; D004797:Enzyme-Linked Immunosorbent Assay; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008875:Middle Aged; D064797:Physical Conditioning, Human / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D012044:Regression Analysis
chemical_list: C508609:IL10 protein, human; C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D016753:Interleukin-10; D002097:C-Reactive Protein