title: Choroidal and Retinal Thickness in Children With Different Refractive Status Measured by Swept-Source Optical Coherence Tomography.
abstract: To investigate the choroidal and retinal thickness in myopic, emmetropic, and hyperopic Chinese children by swept-source longer-wavelength optical coherence tomography.
  
  
  
  Cross-sectional study.
  
  
  
  Two-hundred and seventy-six schoolchildren aged 7-13 years underwent comprehensive ophthalmic examinations, including cycloplegic refraction, and swept-source optical coherence tomography measurements. The thickness of the choroid, retina, ganglion cell layer, and nerve fiber layer were compared among children of different refractive status. The topographic variation and factors related to the thickness of the choroid and retinal layers were analyzed.
  
  
  
  Compared to emmetropic subjects, those with myopia had a significantly thinner choroid in all regions (P < .01), and hyperopic subjects had a thicker choroid in most regions (P < .05). The myopic retinas were thinner than those of emmetropic or hyperopic subjects in the superior parafoveal and all 4 perifoveal subfields (P < .05), but no other subfields differed significantly among different refractive groups (P > .05). The axial length and refractive diopters were independently related to central foveal choroidal thickness (R(2) = 0.17, P < .01), while age and intraocular pressure were independently associated with central fovea retinal (R(2) = 0.15, P < .01) and ganglion cell layer thicknesses (R(2) = 0.10, P < .01) after adjustment for other systematic and ocular factors. Central foveal choroidal and retinal thickness were unrelated in children of different refractive status (P > .05).
  
  
  
  Choroidal thickness, but not retinal thickness, correlated closely with axial length and refractive diopters in Chinese children. Choroid thinning occurs before retina thinning early in myopic progression.
authors.affiliation: Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Peiyao
authors.initials: P
authors.lastname: Jin
authors.affiliation: Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Haidong
authors.initials: H
authors.lastname: Zou
authors.affiliation: Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.
authors.forename: Jiali
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida.
authors.forename: Ta Chen
authors.initials: TC
authors.lastname: Chang
authors.affiliation: Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Lu
authors.affiliation: Jiading Center for Disease Prevention and Control, Shanghai, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Jiading Center for Disease Prevention and Control, Shanghai, China.
authors.forename: Sifei
authors.initials: S
authors.lastname: Sun
authors.affiliation: Jiading Center for Disease Prevention and Control, Shanghai, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yan
authors.affiliation: Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.
authors.forename: Jiangnan
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.
authors.forename: Mingjin
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China; Department of Maternal and Child Health, School of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai, China. Electronic address: xianhezi@163.com.
authors.forename: Xiangui
authors.initials: X
authors.lastname: He
mesh_terms: D000293:Adolescent; D058452:Axial Length, Eye / Q000033:anatomy & histology / Q000473:pathology; D002648:Child; D002829:Choroid / Q000033:anatomy & histology / Q000473:pathology*; D003430:Cross-Sectional Studies; D058453:Emmetropia / Q000502:physiology*; D005260:Female; D006801:Humans; D006956:Hyperopia / Q000473:pathology*; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D009216:Myopia / Q000473:pathology*; D012160:Retina / Q000033:anatomy & histology / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods