title: Stimuli-responsive magnetic nanoparticles for tumor-targeted bimodal imaging and photodynamic/hyperthermia combination therapy.
abstract: Despite magnetic nanoparticles having shown great potential in cancer treatment, tremendous challenges related to diagnostic sensitivity and treatment efficacy for clinical application remain. Herein, we designed optimized multifunctional magnetite nanoparticles (AHP@MNPs), composed of Fe3O4 nanoparticles and photosensitizer conjugated hyaluronic acid (AHP), to achieve enhanced tumor diagnosis and therapy. Fe3O4 nanoparticles (MNPs) were synthesized by a facile hydrolysis method. MNPs have higher biocompatibility, controllable particle sizes, and desirable magnetic properties. The fabricated AHP@MNPs have enhanced water solubility (average size: 108.13 ± 1.08 nm), heat generation properties, and singlet oxygen generation properties upon magnetic and laser irradiation. The AHP@MNPs can target tumors via CD44 receptor-mediated endocytosis, which have enhanced tumor therapeutic effects through photodynamic/hyperthermia-combined treatment without any drugs. We successfully detected tumors implanted in mice via magnetic resonance imaging and optical imaging. Furthermore, we demonstrated the photodynamic/hyperthermia-combined therapeutic efficacy of AHP@MNPs with synergistically enhanced efficacy against cancer.
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43 Jibong ro, Wonmi-gu, Bucheon-si, Gyeonggi do 420-743, Republic of Korea. kna6997@catholic.ac.kr.
authors.forename: Kyoung Sub
authors.initials: KS
authors.lastname: Kim
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43 Jibong ro, Wonmi-gu, Bucheon-si, Gyeonggi do 420-743, Republic of Korea. kna6997@catholic.ac.kr.
authors.forename: Jiyoung
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43 Jibong ro, Wonmi-gu, Bucheon-si, Gyeonggi do 420-743, Republic of Korea. kna6997@catholic.ac.kr.
authors.forename: Joo Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan. osakatets@waseda.jp.
authors.forename: Shofu
authors.initials: S
authors.lastname: Matsuda
authors.affiliation: Research Organization for Nano & Life Innovation, Waseda University, 513 Waseda-tsurumaki-cho, Shinjuku-ku, Tokyo, 162-0041, Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Hideshima
authors.affiliation: CUK-WASEDA Center for Nanotech Research, The Catholic University of Korea, 43 Jibong ro, Wonmi-gu, Bucheon-si, Gyeonggi do 420-743, Republic of Korea.
authors.forename: Yasurou
authors.initials: Y
authors.lastname: Mori
authors.affiliation: Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan. osakatets@waseda.jp and Research Organization for Nano & Life Innovation, Waseda University, 513 Waseda-tsurumaki-cho, Shinjuku-ku, Tokyo, 162-0041, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Osaka
authors.affiliation: Department of Biotechnology, The Catholic University of Korea, 43 Jibong ro, Wonmi-gu, Bucheon-si, Gyeonggi do 420-743, Republic of Korea. kna6997@catholic.ac.kr.
authors.forename: Kun
authors.initials: K
authors.lastname: Na
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006820:Hyaluronic Acid / Q000494:pharmacology; D006979:Hyperthermia, Induced; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D041681:NIH 3T3 Cells; D009374:Neoplasms, Experimental / Q000628:therapy*; D010316:Particle Size; D010778:Photochemotherapy
chemical_list: D058185:Magnetite Nanoparticles; D006820:Hyaluronic Acid