title: The Use of Breast Magnetic Resonance Imaging Parameters to Identify Possible Signaling Pathways of a Serum Biomarker, HE4.
abstract: OBJECTIVE
  This study aimed to investigate the relationship between breast magnetic resonance imaging (MRI) parameters; clinical features such as age, tumor diameter, N, T, and TNM stages; and serum human epididymis protein 4 (HE4) levels in patients with breast carcinoma and use this as a means of estimating possible signaling pathways of the biomarker, HE4.
  
  
  METHODS
  Thirty-seven patients with breast cancer were evaluated by breast MRI and serum HE4 levels before therapy. Correlations between parameters including age, tumor diameter T and N, dynamic curve type, enhancement ratio (ER), slope washin (S-WI), time to peak (TTP), slope washout (S-WO), and the serum level of HE4 were investigated statistically. Human epididymis protein 4 levels of early and advanced stage of disease were also compared statistically.
  
  
  RESULTS
  Breast MRI parameters showed correlation to serum HE4 levels and correlations were statistically significant. Of these MRI parameters, S-WI had higher correlation coefficient than the others. Human epididymis protein 4 levels were not statistically different in early and advanced stage of disease.
  
  
  CONCLUSIONS
  High correlation with MRI parameters related to neoangiogenesis may indicate signaling pathway of HE4.
authors.affiliation: From the *Department of Radiology, Istanbul Medipol University, School of Medicine, Istanbul; Departments of †Radiology, and ‡General Surgery, Atatürk University, School of Medicine; §Department of Pharmaceutical Toxicology, Atatürk University, School of Pharmacy; ∥Department of Radiation Oncology; and ¶Department of Medical Education, Atatürk University, School of Medicine, Erzurum, Turkey.
authors.forename: Afak
authors.initials: A
authors.lastname: Durur-Karakaya
authors.forename: Irmak
authors.initials: I
authors.lastname: Durur-Subasi
authors.forename: Adem
authors.initials: A
authors.lastname: Karaman
authors.forename: Mufide Nuran
authors.initials: MN
authors.lastname: Akcay
authors.forename: Saziye Sezin
authors.initials: SS
authors.lastname: Palabiyik
authors.forename: Burak
authors.initials: B
authors.lastname: Erdemci
authors.forename: Fatih
authors.initials: F
authors.lastname: Alper
authors.forename: Hamit
authors.initials: H
authors.lastname: Acemoglu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009367:Neoplasm Staging; D011506:Proteins / Q000378:metabolism*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015398:Signal Transduction; D013223:Statistics as Topic; D000081102:WAP Four-Disulfide Core Domain Protein 2
chemical_list: D014408:Biomarkers, Tumor; D011506:Proteins; D000081102:WAP Four-Disulfide Core Domain Protein 2; C569698:WFDC2 protein, human