title: CRISPR/Cas9: Implications for Modeling and Therapy of Neurodegenerative Diseases.
abstract: CRISPR/Cas9 is now used widely to genetically modify the genomes of various species. The ability of CRISPR/Cas9 to delete DNA sequences and correct DNA mutations opens up a new avenue to treat genetic diseases that are caused by DNA mutations. In this review, we describe the advantages of using CRISPR/Cas9 to engineer genomic DNAs in animal embryos, as well as in specific regions or cell types in the brain. We also discuss how to apply CRISPR/Cas9 to establish animal models of neurodegenerative diseases, such as Parkinson's and Huntington's disease (HD), and to treat these disorders that are caused by genetic mutations.
authors.affiliation: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences Beijing, China.
authors.forename: Weili
authors.initials: W
authors.lastname: Yang
authors.affiliation: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences Beijing, China.
authors.forename: Zhuchi
authors.initials: Z
authors.lastname: Tu
authors.affiliation: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences Beijing, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Institute of Genetics and Developmental Biology, Chinese Academy of SciencesBeijing, China; Department of Human Genetics, Emory University School of MedicineAtlanta, GA, USA.
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Li
keywords: CRISPR/Cas9; animal models; neurodegenerative diseases