title: A novel way for detection of antiparkinsonism drug entacapone via electrodeposition of silver nanoparticles/functionalized multi-walled carbon nanotubes as an amperometric sensor.
abstract: Silver (Ag) nanoparticles were electrochemically deposited on the film of a metformin functionalized multi-walled carbon nanotube modified glassy carbon electrode (Met-MWCNT/GCE), which fabricated an Ag@Met-MWCNT nanocomposite sensor (Ag@Met-MWCNT/GCE) to detect entacapone (ENT). The Ag@Met-MWCNT nanocomposite was characterized by field emission scanning electrochemical microscopy (FESEM), X-ray diffraction (XRD) analysis, FT-IR and electrochemical tests. The modified electrode showed a large electrocatalytic activity for reduction of ENT. This improved activity indicates that Met@MWCNT plays a crucial role in the dispersion and stabilization of Ag nanoparticles on GCE. Under the optimized conditions the linear range for the detection of the ENT was obtained to be 0.05 to 70.0μM with a low detection limit of 15.3nM. The proposed sensor can effectively analyse ENT concentration in pharmaceutical formulations and human urine samples, avoiding interference, and is a promising ENT sensor due to good sensitivity, stability and low cost.
authors.affiliation: Department of Chemistry, Faculty of Science, Hakim Sabzevari University, P.O. Box 397, Sabzevar, Iran. Electronic address: m.baghayeri@hsu.ac.ir.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Baghayeri
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Maliheh Barazandeh
authors.initials: MB
authors.lastname: Tehrani
authors.affiliation: Department of Chemistry, Faculty of Science, Hakim Sabzevari University, P.O. Box 397, Sabzevar, Iran.
authors.forename: Amirhassan
authors.initials: A
authors.lastname: Amiri
authors.affiliation: Department of Chemistry, Faculty of Science, Hakim Sabzevari University, P.O. Box 397, Sabzevar, Iran.
authors.forename: Behrooz
authors.initials: B
authors.lastname: Maleki
authors.affiliation: Department of Chemistry, Faculty of Science, Hakim Sabzevari University, P.O. Box 397, Sabzevar, Iran.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Farhadi
mesh_terms: D000978:Antiparkinson Agents / Q000032:analysis* / Q000652:urine; D015374:Biosensing Techniques; D002244:Carbon / Q000737:chemistry; D002396:Catechols / Q000032:analysis* / Q000652:urine; D055664:Electrochemical Techniques; D004566:Electrodes; D006801:Humans; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009570:Nitriles / Q000032:analysis* / Q000652:urine; D010084:Oxidation-Reduction; D012834:Silver / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D000978:Antiparkinson Agents; D002396:Catechols; D037742:Nanotubes, Carbon; D009570:Nitriles; D012834:Silver; C071192:entacapone; D002244:Carbon
keywords: Electrodeposition; Entacapone; Metformin; Sensor; Silver nanoparticles