title: Multifocal primary cutaneous extranodal NK/T lymphoma nasal type.
abstract: Nasal type extranodal NK/T-cell lymphoma is a distinct entity according to the World Health Organization classification. Although 60% to 90% of patients with this disease present with a destructive mass in the midline facial tissues, it may also primarily or secondarily involve extranasal sites, like the skin. We report the case of a 77-year-old patient that came to our department with erythematous plaques of the right leg and eczematous lesions of the trunk. These lesions were biopsied and the patient was diagnosed with extranodal NK/T-cell lymphoma, nasal type. He was treated with multi-agent systemic chemotherapy but died 5 months after diagnosis. This case highlights the rarity and variability of cutaneous features of this disease and its aggressive course and poor prognosis.
authors.affiliation: Hospital de Santa Maria, Lisboa, Portugal.
authors.forename: Pedro de
authors.initials: Pd
authors.lastname: Vasconcelos
authors.affiliation: Hospital de Santa Maria, Lisboa, Portugal.
authors.forename: Cristina
authors.initials: C
authors.lastname: Ferreira
authors.affiliation: Hospital de Santa Maria, Lisboa, Portugal.
authors.forename: Luís
authors.initials: L
authors.lastname: Soares-Almeida
authors.affiliation: Hospital de Santa Maria, Lisboa, Portugal.
authors.forename: Paulo
authors.initials: P
authors.lastname: Filipe
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy / Q000473:pathology*; D009669:Nose Neoplasms / Q000188:drug therapy / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone