title: Modeling Meropenem Treatment, Alone and in Combination with Daptomycin, for KPC-Producing Klebsiella pneumoniae Strains with Unusually Low Carbapenem MICs.
abstract: Klebsiella pneumoniae strains producing K. pneumoniae carbapenemase (KPC) cause serious infections in debilitated and immunocompromised patients and are associated with prolonged hospital stays and increased mortality rates. Daptomycin is a lipopeptide used against Staphylococcus aureus infection and considered inactive against Gram-negative bacteria. We investigated the effectiveness of a daptomycin-meropenem combination by synergy kill curve and a pharmacokinetic/pharmacodynamic model. The combination may represent a novel therapeutic strategy against infections caused by KPC-producing K. pneumoniae strains.
authors.affiliation: Houston Methodist Research Institute, Houston, Texas, USA Servicio Antimicrobianos, INEI-ANLIS Dr Carlos Malbrán, Buenos Aires, Argentina.
authors.forename: P
authors.initials: P
authors.lastname: Gagetti
authors.affiliation: Servicio Antimicrobianos, INEI-ANLIS Dr Carlos Malbrán, Buenos Aires, Argentina.
authors.forename: F
authors.initials: F
authors.lastname: Pasteran
authors.affiliation: Houston Methodist Research Institute, Houston, Texas, USA.
authors.forename: M P
authors.initials: MP
authors.lastname: Martinez
authors.affiliation: Houston Methodist Research Institute, Houston, Texas, USA.
authors.forename: M
authors.initials: M
authors.lastname: Fatouraei
authors.affiliation: Houston Methodist Research Institute, Houston, Texas, USA.
authors.forename: J
authors.initials: J
authors.lastname: Gu
authors.affiliation: Houston Methodist Research Institute, Houston, Texas, USA.
authors.forename: R
authors.initials: R
authors.lastname: Fernandez
authors.affiliation: Houston Methodist Research Institute, Houston, Texas, USA.
authors.forename: L
authors.initials: L
authors.lastname: Paz
authors.affiliation: School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors.forename: W E
authors.initials: WE
authors.lastname: Rose
authors.affiliation: Servicio Antimicrobianos, INEI-ANLIS Dr Carlos Malbrán, Buenos Aires, Argentina acorso@anlis.gov.ar aerosato@HoustonMethodist.org.
authors.forename: A
authors.initials: A
authors.lastname: Corso
authors.affiliation: Houston Methodist Research Institute, Houston, Texas, USA acorso@anlis.gov.ar aerosato@HoustonMethodist.org.
authors.forename: A E
authors.initials: AE
authors.lastname: Rosato
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015780:Carbapenems / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology; D013845:Thienamycins / Q000494:pharmacology*; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D015780:Carbapenems; D013845:Thienamycins; D001618:beta-Lactamases; C063912:carbapenemase; D000077731:Meropenem; D017576:Daptomycin