title: [Serial Pathological Changes Between Pre- and Post-pulmonary Artery Banding in a 21-trisomy Patient with Ventricular Septal Defect].
abstract: Although many patients with a ventricular septa defect undergo primary intra-cardiac repair surgery, some patients require 2-stage repair with pulmonary artery banding. Patients with 21-trisomy, who exhibit fragility of the pulmonary vasculature and respiratory systems, may be candidates for this approach. Herein, we report the case of a 21-trisomy patient with ventricular septal defect associated with pulmonary hypertension. She underwent pulmonary artery banding at 4 months of age, and a subsequent radical operation at 27 months. Serial pathological findings between pre- and post-pulmonary artery banding revealed that changes of pulmonary vasculature and respiratory systems were reversible. Her Heath-Edwards grade changed from 0 from II and index of pulmonary vasculature disease changed from 1.1 to 1.0. In conclusion, pulmonary artery banding in a case with pulmonary hypertension prevented the lung from becoming irreversible pathological changes.
authors.affiliation: Division of Cardiovascular Surgery, Jichi Medical University, Shimotsuke, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Sato
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Misawa
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kawada
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Maekawa
mesh_terms: D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications; D008168:Lung / Q000473:pathology; D011651:Pulmonary Artery / Q000601:surgery*