title: Prevalence and genotype distribution of human papillomavirus: implications for cancer screening and vaccination in Henan province, China.
abstract: BACKGROUND
  To provide information for cervical cancer screening and vaccination in Henan province, China, the distribution of human papillomavirus (HPV) was analyzed.
  
  
  METHODS
  The HPV genotypes were detected using gene array and flow-through hybridization.
  
  
  RESULTS
  Overall, 38.1% (1,536/4,033) of the women were human papillomavirus deoxyribonucleic acid (HPV DNA) positive. The prevalence of high-risk HPV types was 32.4%. HPV 16 was the most prevalent genotype (8.9%), followed by HPV 52 (5.8%) and HPV 58 (4.4%).
  
  
  CONCLUSIONS
  The data support close surveillance of women for cervical cancer screening, and HPV prophylactic vaccines including HPV16, HPV 52, and HPV 58 might offer greater protection in this area.
authors.affiliation: Clinical Laboratory, Key Clinical Laboratory of Henan Province, Zhengzhou University, Zhengzhou, China.
authors.forename: Jun-Wei
authors.initials: JW
authors.lastname: Zhao
authors.affiliation: Department of pathology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Xu
authors.affiliation: Key Laboratory of Medical Immunology, Henan University, Zhengzhou, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yan
authors.affiliation: Clinical Laboratory, Key Clinical Laboratory of Henan Province, Zhengzhou University, Zhengzhou, China.
authors.forename: Xiao-Xu
authors.initials: XX
authors.lastname: Sun
authors.affiliation: Clinical Laboratory, Key Clinical Laboratory of Henan Province, Zhengzhou University, Zhengzhou, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Shi
authors.affiliation: Clinical Laboratory, Key Clinical Laboratory of Henan Province, Zhengzhou University, Zhengzhou, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Ming
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002584:Cervix Uteri / Q000821:virology*; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D014626:Vaginal Smears; D055815:Young Adult
chemical_list: D004279:DNA, Viral