title: Glucose-sensitive polymer nanoparticles for self-regulated drug delivery.
abstract: Glucose-sensitive drug delivery systems, which can continuously and automatically regulate drug release based on the concentration of glucose, have attracted much interest in recent years. Self-regulated drug delivery platforms have potential application in diabetes treatment to reduce the intervention and improve the quality of life for patients. At present, there are three types of glucose-sensitive drug delivery systems based on glucose oxidase (GOD), concanavalin A (Con A), and phenylboronic acid (PBA) respectively. This review covers the recent advances in GOD-, Con A-, or PBA-mediated glucose-sensitive nanoscale drug delivery systems, and provides their major challenges and opportunities.
authors.affiliation: Laboratory of Building Energy-Saving Technology Engineering, College of Material Science and Engineering, Jilin Jianzhu University, Changchun 130118, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. jxding@ciac.ac.cn.
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Xiao
authors.affiliation: Laboratory of Building Energy-Saving Technology Engineering, College of Material Science and Engineering, Jilin Jianzhu University, Changchun 130118, P. R. China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Laboratory of Building Energy-Saving Technology Engineering, College of Material Science and Engineering, Jilin Jianzhu University, Changchun 130118, P. R. China.
authors.forename: Guangqing
authors.initials: G
authors.lastname: Gai
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. jxding@ciac.ac.cn.
authors.forename: Jianxun
authors.initials: J
authors.lastname: Ding
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism
chemical_list: D004337:Drug Carriers; D011108:Polymers; D005947:Glucose