title: Progression of aortic regurgitation after subpulmonic infundibular ventricular septal defect repair.
abstract: In patients with subpulmonic infundibular ventricular septal defect (VSD), postoperative progression of aortic regurgitation (AR) sometimes occurs despite early operation before the development of AR. The present study was aimed to identify the occurrence rate and predictors of late AR progression after VSD repair alone.
  
  
  
  We retrospectively investigated 91 consecutive patients who underwent subpulmonic infundibular VSD repair alone and were followed up with echocardiography for >3 years postoperatively. The clinical backgrounds and chronological changes in postoperative AR were evaluated.
  
  
  
  The median follow-up period after VSD repair was 13.4 years. Among 91 patients, 7 patients showed postoperative AR progression (AR progression group) and 84 patients did not (No AR progression group). No patient in AR progression group revealed more than moderate AR preoperatively. The incidence of postoperative VSD leakage was significantly higher in AR progression group than No AR progression group (43.0% vs 2.4%, respectively; p<0.01). No significant differences were present in sex, age, preoperative AR severity, VSD diameter or rate of cusp herniation. All patients in AR progression group showed deformity of the right coronary cusp or leaflet, resulting in AR progression.
  
  
  
  Among patients with subpulmonic infundibular VSD, the incidence of late AR progression after VSD repair alone was unexpectedly high (7.7%). Postoperative VSD leakage may be a significant risk factor for late AR progression. Long-term follow-up of postoperative AR is needed even for patients who undergo VSD repair alone.
authors.affiliation: Department of Cardiology, Tenri Hospital, Tenri, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Amano
authors.affiliation: Department of Cardiology, Tenri Hospital, Tenri, Japan.
authors.forename: Chisato
authors.initials: C
authors.lastname: Izumi
authors.affiliation: Department of Cardiology, Tenri Hospital, Tenri, Japan.
authors.forename: Sari
authors.initials: S
authors.lastname: Imamura
authors.affiliation: Department of Cardiology, Tenri Hospital, Tenri, Japan.
authors.forename: Naoaki
authors.initials: N
authors.lastname: Onishi
authors.affiliation: Department of Cardiology, Tenri Hospital, Tenri, Japan.
authors.forename: Yodo
authors.initials: Y
authors.lastname: Tamaki
authors.affiliation: Department of Cardiology, Tenri Hospital, Tenri, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Enomoto
authors.affiliation: Department of Cardiology, Tenri Hospital, Tenri, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Miyake
authors.affiliation: Department of Cardiology, Tenri Hospital, Tenri, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tamura
authors.affiliation: Department of Cardiology, Tenri Hospital, Tenri, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kondo
authors.affiliation: Department of Cardiology, Tenri Hospital, Tenri, Japan.
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Kaitani
authors.affiliation: Department of Cardiovascular Surgery, Tenri Hospital, Tenri, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamanaka
authors.affiliation: Department of Cardiology, Tenri Hospital, Tenri, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nakagawa
mesh_terms: D000293:Adolescent; D000328:Adult; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D018618:Echocardiography, Doppler, Color; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult