title: Indocyanine Green-Loaded Polydopamine-Reduced Graphene Oxide Nanocomposites with Amplifying Photoacoustic and Photothermal Effects for Cancer Theranostics.
abstract: Photoacoustic (PA) imaging and photothermal therapy (PTT) as light-induced theranostic platforms have been attracted much attention in recent years. However, the development of highly efficient and integrated phototheranostic nanoagents for amplifying PA imaging and PTT treatments poses great challenges. Here, we report a novel phototheranostic nanoagent using indocyanine green-loaded polydopamine-reduced graphene oxide nanocomposites (ICG-PDA-rGO) with amplifying PA and PTT effects for cancer theranostics. The results demonstrate that the PDA layer coating on the surface of rGO could effectively absorb a large number of ICG molecules, quench ICG's fluorescence, and enhance the PDA-rGO's optical absorption at 780 nm. The obtained ICG-PDA-rGO exhibits stronger PTT effect and higher PA contrast than that of pure GO and PDA-rGO. After PA imaging-guided PTT treatments, the tumors in 4T1 breast subcutaneous and orthotopic mice models are suppressed completely and no treatment-induced toxicity being observed. It illustrates that the ICG-PDA-rGO nanocomposites constitute a new class of theranostic nanomedicine for amplifying PA imaging and PTT treatments.
authors.affiliation: 1. Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P.R. China;; 2. Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China.
authors.forename: Dehong
authors.initials: D
authors.lastname: Hu
authors.affiliation: 1. Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P.R. China;
authors.forename: Jingnan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: 3. Paul-Drude Institut, Leibniz-Institut im Forschungsverbund, Hausvogteiplatz 5-7, 10117, Berlin, Germany.
authors.forename: Guanhui
authors.initials: G
authors.lastname: Gao
authors.affiliation: 1. Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P.R. China;; 2. Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China.
authors.forename: Zonghai
authors.initials: Z
authors.lastname: Sheng
authors.affiliation: 1. Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P.R. China;
authors.forename: Haodong
authors.initials: H
authors.lastname: Cui
authors.affiliation: 1. Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P.R. China;
authors.forename: Lintao
authors.initials: L
authors.lastname: Cai
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D004396:Coloring Agents / Q000008:administration & dosage*; D004195:Disease Models, Animal; D006108:Graphite / Q000008:administration & dosage*; D006979:Hyperthermia, Induced; D007208:Indocyanine Green / Q000008:administration & dosage; D007211:Indoles / Q000008:administration & dosage*; D008807:Mice, Inbred BALB C; D053761:Nanocomposites / Q000008:administration & dosage*; D010087:Oxides / Q000008:administration & dosage; D061088:Photoacoustic Techniques; D010789:Phototherapy; D011108:Polymers / Q000008:administration & dosage*; D000068936:Theranostic Nanomedicine / Q000379:methods; D016896:Treatment Outcome
chemical_list: D004396:Coloring Agents; D007211:Indoles; D010087:Oxides; D011108:Polymers; C568283:polydopamine; D006108:Graphite; D007208:Indocyanine Green
keywords: Indocyanine green; Photoacoustic imaging; Photothermal therapy.; Reduced graphene oxide; Theranostics