title: Challenges of diagnosing and managing the adolescent with heavy menstrual bleeding.
abstract: Unpredictable, prolonged or heavy menstrual bleeding (HMB) may be expected for many adolescents soon after menarche. A decade of clinical experience and research has now established firmly that bleeding disorders (BD) are common in adolescents with HMB. Despite these advances, many questions remain, and several aspects of the diagnosis and management of BDs in adolescents are not supported by rigorous clinical trials. In this overview, four major areas will be discussed. First, we will discuss the frequency of BDs in young women with HMB. Up to 20% of older females with HMB are thought to have an underlying BD. Estimates from retrospective studies in adolescents suggest a prevalence that varies anywhere from 10 to 62%. Prospective studies with uniform hemostatic evaluation are needed to answer this question definitively. Second, we will review existing tools that help screen and diagnose adolescents with HMB with an underlying BD. Although identification of an underlying BD in older women with HMB is relatively straight forward, uncertainties remain for adolescents. Heavy menstrual bleeding in this age group may have different pathophysiological underpinnings than those in older women and may often be disregarded as anovulatory. There is an urgent need to develop novel tools, and evaluate existing diagnostic strategies in adolescents. Third, we will discuss the optimal medical management of HMB in young adolescents. As direct evidence is largely lacking, these areas are also subject to extrapolation from older women. Lastly, an important area- prediction, and management of future bleeding in those adolescents who are diagnosed with a mild BD-will be discussed. Throughout, areas of controversy and opportunities for further research are highlighted.
authors.affiliation: Department of Pediatrics, The University of Texas Southwestern Medical Center, United States; Division of Hematology/Oncology, The University of Texas Southwestern Medical Center, United States; The Carman Ann Adams Department of Pediatrics, Division of Hematology/Oncology, Wayne State University School of Medicine, Detroit, MI, United States. Electronic address: Ayesha.zia@utsouthwestern.edu.
authors.forename: Ayesha
authors.initials: A
authors.lastname: Zia
authors.affiliation: Department of Pediatrics, The University of Texas Southwestern Medical Center, United States; Division of Hematology/Oncology, The University of Texas Southwestern Medical Center, United States; The Carman Ann Adams Department of Pediatrics, Division of Hematology/Oncology, Wayne State University School of Medicine, Detroit, MI, United States.
authors.forename: Madhvi
authors.initials: M
authors.lastname: Rajpurkar
mesh_terms: D000293:Adolescent; D001778:Blood Coagulation Disorders / Q000150:complications / Q000175:diagnosis; D003276:Contraceptives, Oral / Q000627:therapeutic use; D005260:Female; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D008595:Menorrhagia / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology / Q000601:surgery
chemical_list: D003276:Contraceptives, Oral; D006728:Hormones
keywords: Abnormal uterine bleeding; Adolescents; Bleeding disorders; Comprehensive care; Heavy menstrual bleeding