title: Tension-Time Integrals and Genetic Cardiomyopathy: The Force Is with You.
abstract: Hundreds of different mutations in genes encoding a few dozen sarcomeric proteins cause two reciprocal human disease phenotypes, hypertrophic or dilated cardiomyopathy. How molecular dysfunction evokes different patterns of cardiac remodeling is unclear. Davis et al. describe a biophysical metric of cardiomyocyte function, the force-time integral, which predicts disease phenotype.
authors.affiliation: Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: gdorn@wustl.edu.
authors.forename: Gerald W
authors.initials: GW
authors.lastname: Dorn
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D006321:Heart; D006801:Humans; D009154:Mutation; D010641:Phenotype