title: Factors associated with non-adherence to the treatment of vivax malaria in a rural community from the Brazilian Amazon Basin.
abstract: INTRODUCTION We investigated the association between demographic and behavioral factors and non-adherence to antimalarial therapy. METHODS A demographic questionnaire and 5-item self-reported questionnaire regarding non-adherence were completed by 135 patients after treatment for Plasmodium vivax. RESULTS Treatment interruption, but not demographic factors, was significantly associated with non-adherence to therapy. The likelihood of non-adherence was 5.16 times higher when the patients felt better than when they felt worse. The relative risk of parasitic resurgence was 3.04 times higher in non-adherent patients. CONCLUSIONS Treatment interruption is significantly associated with treatment adherence.
authors.affiliation: Faculdade de Farmácia, Universidade Federal do Pará, Belém, Pará, Brazil.
authors.forename: Eduardo Dias
authors.initials: ED
authors.lastname: Almeida
authors.affiliation: Faculdade de Farmácia, Universidade Federal do Pará, Belém, Pará, Brazil.
authors.forename: José Luiz Fernandes
authors.initials: JL
authors.lastname: Vieira
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000627:therapeutic use*; D001938:Brazil; D002738:Chloroquine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016780:Malaria, Vivax / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011319:Primaquine / Q000627:therapeutic use*; D011446:Prospective Studies; D012424:Rural Population; D011795:Surveys and Questionnaires; D055815:Young Adult; D016903:Drug Monitoring
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D011319:Primaquine