title: [Pathophysiology of preeclampsia].
abstract: Preeclampsia is a hypertensive disease of pregnancy due to abnormal utero-placental circulation. Hypoperfusion of the placenta and hypoxia/reoxygenation of the intervillous space are responsible of placental dysfunction. Trophoblastic factors are released in the maternal circulation and are responsible of the maternal endothelial dysfunction that characterize preeclampsia. Among those factors, the PlGF/sFlt-1 couple plays a major pathophysiologic role.
authors.affiliation: Assistance publique-Hôpitaux de Paris, centre hospitalier universitaire Cochin Broca-Hôtel-Dieu, université Paris-Descartes, 75014 Paris, France; Inserm, UMR-S 1139, 75006 Paris, France; DHU risques et grossesse, 75014 Paris, France; Fondation PremUP, 75014 Paris, France.
authors.forename: Edouard
authors.initials: E
authors.lastname: Lecarpentier
authors.affiliation: Inserm, UMR-S 1139, 75006 Paris, France; DHU risques et grossesse, 75014 Paris, France; Fondation PremUP, 75014 Paris, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Fournier
authors.affiliation: Assistance publique-Hôpitaux de Paris, centre hospitalier universitaire Cochin Broca-Hôtel-Dieu, université Paris-Descartes, 75014 Paris, France; Inserm, UMR-S 1139, 75006 Paris, France; DHU risques et grossesse, 75014 Paris, France; Fondation PremUP, 75014 Paris, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Guibourdenche
authors.affiliation: Assistance publique-Hôpitaux de Paris, centre hospitalier universitaire Cochin Broca-Hôtel-Dieu, université Paris-Descartes, 75014 Paris, France; Inserm, UMR-S 1139, 75006 Paris, France; DHU risques et grossesse, 75014 Paris, France; Fondation PremUP, 75014 Paris, France. Electronic address: vassilis.tsatsaris@cch.aphp.fr.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Tsatsaris
mesh_terms: D005260:Female; D006801:Humans; D010920:Placenta / Q000503:physiopathology; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D014599:Uterus / Q000098:blood supply