title: Host responses to a strontium releasing high boron glass using a rabbit bilateral femoral defect model.
abstract: Borate glasses have shown promising potential as bioactive materials. With recent research demonstrating that glass properties may be modulated by appropriate compositional design. This may provide for indication specific material characteristics and controlled release of therapeutic inorganic ions (i.e., strontium); controlling such release is critical in order to harness the therapeutic potential. Within this sub-chronic pilot study, a rabbit long-bone model was utilized to explore the safety and efficacy of a high borate glass (LB102: 70B2O3-20SrO-6Na2O-4La2O3) particulate (90 - 710 μm) for bone regeneration. Six bilateral full-thickness defects (Ø = 3.5 mm; L = 8 mm) were created in three white New Zealand rabbits. Longitudinal non-decalcified sections of each defect site were produced and stained with Goldner's Trichrome. Histopathological examination revealed that LB102 demonstrated osteoconductive and osseointegrative properties with greater new bone being formed within and surrounding LB102 particles, when compared to the sham control. The inflammatory cell infiltration was observed to be slightly higher in the control when compared to LB102 defect sites, while no significant difference in fibrosis and neovascularization was determined, indicating that healing was occurring in a normal fashion. These data further suggest the possible utility of high borate glasses with appropriate compositional design for medical applications, such as bone augmentation. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1818-1827, 2017.
authors.affiliation: Department of Biological Sciences, Cork Institute of Technology, Cork, Ireland.
authors.forename: Kathleen
authors.initials: K
authors.lastname: O'Connell
authors.affiliation: Department of Applied Oral Sciences, Dalhousie University, Halifax, NS, Canada.
authors.forename: Caitlin
authors.initials: C
authors.lastname: Pierlot
authors.affiliation: Department of Biological Sciences, Cork Institute of Technology, Cork, Ireland.
authors.forename: Helen
authors.initials: H
authors.lastname: O'Shea
authors.affiliation: Orthopedics and Biomaterials Lab, AccelLAB Inc., Boisbriand, QC, Canada.
authors.forename: Diane
authors.initials: D
authors.lastname: Beaudry
authors.affiliation: Orthopedics and Biomaterials Lab, AccelLAB Inc., Boisbriand, QC, Canada.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Chagnon
authors.affiliation: Orthopedics and Biomaterials Lab, AccelLAB Inc., Boisbriand, QC, Canada.
authors.forename: Michel
authors.initials: M
authors.lastname: Assad
authors.affiliation: Department of Applied Oral Sciences, Dalhousie University, Halifax, NS, Canada.|School of Biomedical Engineering, Dalhousie University, Halifax, NS, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Boyd
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D001895:Boron / Q000737:chemistry*; D005264:Femoral Fractures / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D005269:Femur / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D017102:Fracture Healing / Q000187:drug effects*; D005898:Glass / Q000737:chemistry*; D011817:Rabbits; D013324:Strontium / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D001895:Boron; D013324:Strontium
keywords: animal model; biocompatibility/hard tissue; borate glass; strontium