title: Mechanisms of Cellular Membrane Reorganization to Support Hepatitis C Virus Replication.
abstract: Like all positive-sense RNA viruses, hepatitis C virus (HCV) induces host membrane alterations for its replication termed the membranous web (MW). Assembling replication factors at a membranous structure might facilitate the processes necessary for genome replication and packaging and shield viral components from host innate immune defenses. The biogenesis of the HCV MW is a complex process involving a concerted effort of HCV nonstructural proteins with a growing list of host factors. Although a comprehensive understanding of MW formation is still missing, a number of important viral and host determinants have been identified. This review will summarize the recent studies that have led to our current knowledge of the role of viral and host factors in the biogenesis of the MWs and discuss how HCV uses this specialized membrane structure for its replication.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA. wanghon@med.umich.edu.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA. andrewwt@med.umich.edu.|Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. andrewwt@med.umich.edu.|Medicine Service, Ann Arbor Veterans Administration Health System, Ann Arbor, MI 48105, USA. andrewwt@med.umich.edu.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Tai
mesh_terms: D002462:Cell Membrane / Q000378:metabolism* / Q000821:virology*; D016174:Hepacivirus / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D001678:Organelle Biogenesis; D014779:Virus Replication
keywords: RNA virus; double membrane vesicle; phosphatidylinositol 4-kinase; phosphatidylinositol 4-phosphate; viral replication