title: Transitional Progenitors during Vertebrate Retinogenesis.
abstract: The retina is a delicate neural tissue responsible for light signal capturing, modulating, and passing to mid-brain. The brain then translated the signals into three-dimensional vision. The mature retina is composed of more than 50 subtypes of cells, all of which are developed from a pool of early multipotent retinal progenitors, which pass through sequential statuses of oligopotent, bipotent, and unipotent progenitors, and finally become terminally differentiated retinal cells. A transitional progenitor model is proposed here to describe how intrinsic developmental programs, along with environmental cues, control the step-by-step differentiation during retinogenesis. The model could elegantly explain many current findings as well as predict roles of intrinsic factors during retinal development.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 South Xianlie Road, Guangzhou, Gongdong, 510060, China. kxjin@yahoo.com.
authors.forename: Kangxin
authors.initials: K
authors.lastname: Jin
authors.forename: Mengqing
authors.initials: M
authors.lastname: Xiang
mesh_terms: D000818:Animals; D008954:Models, Biological; D038081:Organogenesis; D012160:Retina / Q000166:cytology* / Q000196:embryology*; D013234:Stem Cells / Q000166:cytology*; D013269:Stochastic Processes; D014714:Vertebrates / Q000196:embryology*
keywords: Cell fate; Development; Differentiation; Intrinsic program; Multipotent; Progenitor; Retina; Retinogenesis; Stochastic mechanism; Transcription factor