title: Follicular dendritic cell tumour/sarcoma: a commonly misdiagnosed tumour in the thorax.
abstract: OBJECTIVE
  Follicular dendritic cell sarcoma is a rare tumour reported to occur occasionally in association with the hyaline-vascular type of Castleman's disease (HVCD). Most cases arise in lymph nodes, although extranodal presentation is described.
  
  
  RESULTS
  Clinical, radiological and histological characteristics, including diagnosis on pre-resection material, were assessed in seven intrathoracic cases from five males and two females with a median age of 38 years. Clinical symptoms were related to mass location, six cases presenting within central and/or posterior mediastinal compartments and one within the lungs. Positron emission tomography-computed tomography demonstrated marked fluoro-deoxy-glucose avidity and the prominent vessels traversing the lesions. Four of six cases (67%) were misdiagnosed initially. HVCD was present in three cases. Two cases with high mitotic rates recurred after resection. All were positive for at least one of the follicular dendritic cell markers (CD21, CD35 and CD23). Six of seven cases (86%) show cyclin D1 expression ranging from 5% to 90%.
  
  
  CONCLUSIONS
  Follicular dendritic cell sarcoma is often misdiagnosed on biopsy and pathologists need to be aware of the tumour to request the relevant immunohistochemistry, especially in masses presenting in the central/posterior mediastinum with high vascularity and standardized uptake values. Background HVCD appears more common than previously thought.
authors.affiliation: Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Viola
authors.affiliation: Department of Histopathology, Royal Marsden Foundation Trust, London, UK.
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Vroobel
authors.affiliation: Department of Imaging, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
authors.forename: Anand
authors.initials: A
authors.lastname: Devaraj
authors.affiliation: Department of Thoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
authors.forename: Simon
authors.initials: S
authors.lastname: Jordan
authors.affiliation: Department of Thoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
authors.forename: George
authors.initials: G
authors.lastname: Ladas
authors.affiliation: Department of Thoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Dusmet
authors.affiliation: Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust, London, UK.|National Heart and Lung Institute, Imperial College, London, UK.
authors.forename: Angeles
authors.initials: A
authors.lastname: Montero
authors.affiliation: Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust, London, UK.|National Heart and Lung Institute, Imperial College, London, UK.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Rice
authors.affiliation: Department of Histopathology, Royal Marsden Foundation Trust, London, UK.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Wotherspoon
authors.affiliation: Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust, London, UK. a.nicholson@rbht.nhs.uk.|National Heart and Lung Institute, Imperial College, London, UK. a.nicholson@rbht.nhs.uk.
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Nicholson
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D054740:Dendritic Cell Sarcoma, Follicular / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008875:Middle Aged; D013909:Thorax; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor
keywords: follicular dendritic cell tumour/sarcoma; immunohistochemistry; lung; mediastinum