title: Macular Retinal Ganglion Cell Layer Thickness Is Not Reduced in Patients with Obstructive Sleep Apnea.
abstract: OBJECTIVE
  To evaluate macular ganglion cell layer (GCL) and ganglion cell-inner plexiform layer (GCIPL) thicknesses in patients with obstructive sleep apnea (OSA) syndrome.
  
  
  METHODS
  73 OSA patients and 67 age-matched controls were consecutively and prospectively enrolled. All participants underwent at least one reliable standard automated perimetry (SAP) and were imaged with spectral-domain optical coherence tomography (OCT) using two different devices. The OCT parameters were compared between groups, and Pearson correlations between main indices of SAP and OCT parameters were calculated.
  
  
  RESULTS
  The pattern standard deviation of SAP was higher in the OSA group (p = 0.001). Mean GCIPL thickness was 82.99 ± 10.30 and 80.78 ± 12.15 µm in the control and OSA groups, respectively (p = 0.25), and GCL thickness was 44.93 ± 11.42 µm in the control group and 48.81 ± 10.85 µm in OSA individuals (p = 0.47). Pearson correlations between the GCIPL-GCL measurements and the main indices of SAP were not significant.
  
  
  CONCLUSIONS
  Neither GCIPL nor GCL thickness were reduced in OSA subjects compared with healthy individuals. Retinal sensitivity evaluated with SAP was however decreased in OSA patients.
authors.affiliation: Department of Ophthalmology, IIS-Aragx00F3;n, Miguel Servet University Hospital, Zaragoza, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Ferrandez
authors.forename: Antonio
authors.initials: A
authors.lastname: Ferreras
authors.forename: Pilar
authors.initials: P
authors.lastname: Calvo
authors.forename: Beatriz
authors.initials: B
authors.lastname: Abadia
authors.forename: Ana B
authors.initials: AB
authors.lastname: Pajarin
authors.forename: Jose M
authors.initials: JM
authors.lastname: Marin
authors.forename: Michele
authors.initials: M
authors.lastname: Iester
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D011446:Prospective Studies; D012164:Retinal Diseases / Q000175:diagnosis / Q000209:etiology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000503:physiopathology; D041623:Tomography, Optical Coherence / Q000379:methods*