title: Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro.
abstract: A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl(-) transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus in vitro.
authors.affiliation: Department of Chemistry, The University of Texas, Austin, TX 78712-1224, USA. sessler@cm.utexas.edu.
authors.forename: Andrew I
authors.initials: AI
authors.lastname: Share
authors.forename: Khushali
authors.initials: K
authors.lastname: Patel
authors.forename: Cristina
authors.initials: C
authors.lastname: Nativi
authors.forename: Eun J
authors.initials: EJ
authors.lastname: Cho
authors.forename: Oscar
authors.initials: O
authors.lastname: Francesconi
authors.forename: Nathalie
authors.initials: N
authors.lastname: Busschaert
authors.forename: Philip A
authors.initials: PA
authors.lastname: Gale
authors.forename: Stefano
authors.initials: S
authors.lastname: Roelens
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Sessler
mesh_terms: D027321:Anion Transport Proteins / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D008081:Liposomes; D055624:Methicillin-Resistant Staphylococcus aureus / Q000254:growth & development / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D027321:Anion Transport Proteins; D000900:Anti-Bacterial Agents; D002712:Chlorides; D008081:Liposomes