title: Study of the tetraspanin 18 association with schizophrenia in a Han Chinese population.
abstract: A genome-wide association study of Han Chinese samples identified three single-nucleotide polymorphisms in the tetraspanin 18 (TSPAN18) gene to be associated with schizophrenia. However, the replication of the TSPAN18 association was inconsistent across studies. To explore the possible reason for poor replication, we conducted a case-control study to validate the TSPAN18 finding in an independent Chinese sample. The frequency of rs11038167 minor allele (A) was significantly higher only in female patients with thought disorder. Our result suggested that the TSPAN18 gene may be involved in the development of psychotic symptoms and contribute to clinical heterogeneity of schizophrenia.
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing, 100073, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wu
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing, 100073, PR China.
authors.forename: Fengping
authors.initials: F
authors.lastname: Chen
authors.affiliation: Division of Health Research, University of the Highlands & Islands, Centre for Health Science, Old Perth Road, Inverness IV2 3JH, UK.
authors.forename: Jun
authors.initials: J
authors.lastname: Wei
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing, 100073, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing, 100073, PR China. Electronic address: xuqi@pumc.edu.cn.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011618:Psychotic Disorders / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*; D012737:Sex Factors; D059470:Tetraspanins / Q000235:genetics*
chemical_list: C556852:TSPAN18 protein, human; D059470:Tetraspanins
keywords: Heterogeneity; Schizophrenia; Tetraspanin 18