title: Hyperpolarization of Nitrogen-15 Schiff Bases by Reversible Exchange Catalysis with para-Hydrogen.
abstract: NMR with thermal polarization requires relatively concentrated samples, particularly for nuclei with low abundance and low gyromagnetic ratios, such as (15) N. We expand the substrate scope of SABRE, a recently introduced hyperpolarization method, to allow access to (15) N-enriched Schiff bases. These substrates show fractional (15) N polarization levels of up to 2 % while having only minimal (1) H enhancements.
authors.affiliation: Department of Chemistry, Duke University, French Family Science Center, 124 Science Drive, Durham, NC, 27708, USA.
authors.forename: Angus W J
authors.initials: AW
authors.lastname: Logan
authors.affiliation: Department of Chemistry, Duke University, French Family Science Center, 124 Science Drive, Durham, NC, 27708, USA. steven.malcolmson@duke.edu.
authors.forename: Thomas
authors.initials: T
authors.lastname: Theis
authors.affiliation: Department of Chemistry, Duke University, French Family Science Center, 124 Science Drive, Durham, NC, 27708, USA.
authors.forename: Johannes F P
authors.initials: JF
authors.lastname: Colell
authors.affiliation: Department of Chemistry, Duke University, French Family Science Center, 124 Science Drive, Durham, NC, 27708, USA.|Department of Physics, Duke University, French Family Science Center, 124 Science Drive, Durham, NC, 27708, USA.|Department of Radiology, Duke University, French Family Science Center, 124 Science Drive, Durham, NC, 27708, USA.
authors.forename: Warren S
authors.initials: WS
authors.lastname: Warren
authors.affiliation: Department of Chemistry, Duke University, French Family Science Center, 124 Science Drive, Durham, NC, 27708, USA. thomas.theis@duke.edu.
authors.forename: Steven J
authors.identifier: http://orcid.org/0000-0003-3229-0949
authors.initials: SJ
authors.lastname: Malcolmson
keywords: NMR spectroscopy; amino acids; homogeneous catalysis; imaging agents; iridium