title: Establishing a clinical service for the treatment of osteoid osteoma using magnetic resonance-guided focused ultrasound: overview and guidelines.
abstract: Recent studies have demonstrated the effectiveness of magnetic resonance-guided focused ultrasound (MRgFUS) in the treatment of osteoid osteoma (OO), a painful, benign bone tumor. As MRgFUS is a noninvasive and radiation-free treatment, it stands to replace the current standard of care, percutaneous radiofrequency, or laser thermal ablation. Within an institution, creation of a clinical OO MRgFUS treatment program would not only provide cutting edge medical treatment at the current time but would also establish the foundation for an MRgFUS clinical service to introduce treatments currently under development into clinical practice in the future. The purpose of this document is to provide information to facilitate creation of a clinical service for MRgFUS treatment of OO by providing (1) recommendations for the multi-disciplinary management of patients and (2) guidelines regarding current best practices for MRgFUS treatment. This paper will discuss establishment of a multi-disciplinary clinic, patient accrual, inclusion/exclusion criteria, diagnosis, preoperative imaging, patient preparation, anesthesia, treatment planning, targeting and treatment execution, complication avoidance, and patient follow-up to assure safety and effectiveness.
authors.affiliation: The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8 Canada.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Temple
authors.affiliation: The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8 Canada.
authors.forename: Adam C
authors.initials: AC
authors.lastname: Waspe
authors.affiliation: The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8 Canada.
authors.forename: Joao G
authors.initials: JG
authors.lastname: Amaral
authors.affiliation: Sapienza University of Rome, Piazalle Aldo Moro, 5, Rome, 00185 Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Napoli
authors.affiliation: University MRI Image Guided Therapy Center, 3848 Fau Blvd., Suite 200, Boca Raton, FL 33431 USA.
authors.forename: Suzanne
authors.initials: S
authors.lastname: LeBlang
authors.affiliation: Stanford University Medical Center, 1201 Welch Road, Room P267, Stanford, CA 94305 USA.
authors.forename: Pejman
authors.initials: P
authors.lastname: Ghanouni
authors.affiliation: UCSF School of Medicine, 513 Parnassus Ave., San Francisco, CA 94143-0410 USA.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Bucknor
authors.affiliation: The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8 Canada.
authors.forename: Fiona
authors.initials: F
authors.lastname: Campbell
authors.affiliation: The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8 Canada.
authors.forename: James M
authors.initials: JM
authors.lastname: Drake
keywords: Ablation; Bone; Clinical; Focused ultrasound; Guideline; Osteoid osteoma; Review; Therapy