title: Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect.
abstract: In this article, liposome-based coatings aiming to control drug release from therapeutic soft contact lenses (SCLs) materials are analyzed. A PHEMA based hydrogel material loaded with levofloxacin is used as model system for this research. The coatings are formed by polyelectrolyte layers containing liposomes of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and DMPC + cholesterol (DMPC + CHOL). The effect of friction and temperature on the drug release is investigated. The aim of the friction tests is to simulate the blinking of the eyelid in order to verify if the SCLs materials coated with liposomes are able to keep their properties, in particular the drug release ability. It was observed that under the study conditions, friction did not affect significantly the drug release from the liposome coated PHEMA material. In contrast, increasing the temperature of release leads to an increase of the drug diffusion rate through the hydrogel. This phenomenon is recorded both in the control and in the coated samples. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1799-1807, 2017.
authors.affiliation: Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, University of Lisbon, 1049-001, Lisboa, Portugal.|Mechanical Engineering Department and IDMEC, Instituto Superior Técnico, University of Lisbon, 1049-001, Lisboa, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Paradiso
authors.affiliation: Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, University of Lisbon, 1049-001, Lisboa, Portugal.|Mechanical Engineering Department and IDMEC, Instituto Superior Técnico, University of Lisbon, 1049-001, Lisboa, Portugal.
authors.forename: R
authors.initials: R
authors.lastname: Colaço
authors.affiliation: Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, University of Lisbon, 1049-001, Lisboa, Portugal.
authors.forename: J L G
authors.initials: JLG
authors.lastname: Mata
authors.affiliation: NMI - Natural and Medical Sciences Institute at the University of Tuebingen, 72770, Reutlingen, Germany.|Reutlingen University, D-72762, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Krastev
authors.affiliation: Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, University of Lisbon, 1049-001, Lisboa, Portugal.
authors.forename: B
authors.initials: B
authors.lastname: Saramago
authors.affiliation: Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, University of Lisbon, 1049-001, Lisboa, Portugal.|Centro de Investigação Interdisciplinar Egas Moniz, Instituto Superior de Ciências da Saúde Egas Moniz, Quinta da Granja, Monte de Caparica, 2829-511, Caparica, Portugal.
authors.forename: A P
authors.initials: AP
authors.lastname: Serro
mesh_terms: D001767:Blinking; D002784:Cholesterol / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003263:Contact Lenses, Hydrophilic; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006358:Hot Temperature; D006801:Humans; D008081:Liposomes
chemical_list: D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D008081:Liposomes; D002784:Cholesterol; D004134:Dimyristoylphosphatidylcholine
keywords: drug release; eyelid; friction; liposomes; soft contact lenses