title: Clinical prognostic factors in adults with astrocytoma: Historic cohort.
abstract: OBJECTIVE
  To explore the clinical prognostic factors for adults affected with astrocytoma.
  
  
  METHODS
  Using a historic cohort, we selected 155 clinical files from patients with astrocytoma using simple randomization. The main outcome variable was overall survival time. To identify clinical prognostic factors, we used bivariate analysis, Kaplan Meier, the log rank test and the Cox regression models. The number of lost years lived with disability (DALY) based on prevalence, was calculated.
  
  
  RESULTS
  The mean age at diagnosis was 45.7 years. Analysis according to tumour stage, including grades II, III and IV, also showed a younger age of presentation. Kaplan-Meier survival estimates showed that tumour grade, Karnofsky status (KPS) ≥70, resection type, chemotherapy, radiotherapy, alcohol consumption, familial history of cancer and clinical presentation were significantly associated with survival time. Using a proportional hazard model, age, grade IV, resection, chemotherapy+radiotherapy and KPS were identified as prognostic factors.The amount of life lost due to premature death in this population was 28 years.
  
  
  CONCLUSIONS
  In our study, astrocytoma was diagnosed in young adults. The overall survival was 15 months, 9% (n=14) of patients presented a survival of 2 years, and 3% of patients survived 3 years. On average the number of years lost due to premature death and disability was 28.53 years.
authors.affiliation: Dirección de Investigación, Instituto Nacional de Cancerologia, San Fernando 22, Sección XVI, CP 14080 Tlalpan, CDMX, Mexico. Electronic address: taliaw@gmail.com.
authors.forename: Talia
authors.initials: T
authors.lastname: Wegman-Ostrosky
authors.affiliation: Dirección de Investigación, Instituto Nacional de Cancerologia, San Fernando 22, Sección XVI, CP 14080 Tlalpan, CDMX, Mexico. Electronic address: nrn231002@yahoo.com.mx.
authors.forename: Nancy
authors.initials: N
authors.lastname: Reynoso-Noverón
authors.affiliation: Subdirección de Neurocirugía, Instituto Nacional de Neurología y Neurocirugía, Insurgentes Sur # 3877, CP 14269 Tlalpan, CDMX, Mexico. Electronic address: soniamejia@neurocirugia-innn.com.
authors.forename: Sonia I
authors.initials: SI
authors.lastname: Mejía-Pérez
authors.affiliation: Subdirección de Neurocirugía, Instituto Nacional de Neurología y Neurocirugía, Insurgentes Sur # 3877, CP 14269 Tlalpan, CDMX, Mexico. Electronic address: thaesa@gmail.com.
authors.forename: Thalía E
authors.initials: TE
authors.lastname: Sánchez-Correa
authors.affiliation: Dirección de Investigación, Instituto Nacional de Cancerologia, San Fernando 22, Sección XVI, CP 14080 Tlalpan, CDMX, Mexico. Electronic address: rosamag2@hotmail.com.
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Alvarez-Gómez
authors.affiliation: Dirección de Investigación, Instituto Nacional de Cancerologia, San Fernando 22, Sección XVI, CP 14080 Tlalpan, CDMX, Mexico. Electronic address: vidals02@yahoo.com.
authors.forename: Silvia
authors.initials: S
authors.lastname: Vidal-Millán
authors.affiliation: Departamento Neuro-oncologia, Instituto Nacional de Cancerologia San Fernando 22, Sección XVI, CP 14080 Tlalpan, CDMX, Mexico. Electronic address: bernardocacho@doctor.com.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Cacho-Díaz
authors.affiliation: Dirección Centro de Investigaciones Biomedicas, Cetro Médico de Occidente, IMSS, Sierra mojada 800, 44340 Guadalajara, Jalisco, Mexico. Electronic address: josancomx@yahoo.com.mx.
authors.forename: José
authors.initials: J
authors.lastname: Sánchez-Corona
authors.affiliation: Dirección de Investigación, Instituto Nacional de Cancerologia, San Fernando 22, Sección XVI, CP 14080 Tlalpan, CDMX, Mexico. Electronic address: herreram@biomedicas.unam.mx.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Herrera-Montalvo
authors.affiliation: Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Insurgentes Sur # 3877, CP 14269 Tlalpan, CDMX, Mexico. Electronic address: coronav@unam.mx.
authors.forename: Teresa
authors.initials: T
authors.lastname: Corona-Vázquez
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000453:epidemiology* / Q000401:mortality; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000401:mortality; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged
keywords: Astrocytoma; Cohort study; Glioblastoma; Life lost due to premature death; Primary brain tumour; Prognosis