title: Re-irradiation using proton beam therapy combined with weekly intra-arterial chemotherapy for recurrent oral cancer.
abstract: OBJECTIVE
  The purpose of this study was to clarify the efficacy and toxicities of re-irradiation using proton beam therapy combined with weekly intra-arterial chemotherapy for recurrent oral cancer.
  
  
  METHODS
  Between October 2009 and July 2014, 34 patients who had recurrent oral cancer were treated by proton beam therapy combined with intra-arterial infusion chemotherapy at the Southern Tohoku Proton Therapy Center, Japan.
  
  
  RESULTS
  For all patients, the median follow-up was 25 months (range, 3-77 months). After treatment, 22 patients (65%) achieved a complete response, and 12 patients (35%) achieved a partial response at the primary tumor site. One-year and 2-year overall survival (OS) rates were 62% and 42%, respectively. One-year and 2-year LC rates were 77% and 60%, respectively. No treatment-related deaths were observed during the treatment and follow-up periods.
  
  
  CONCLUSIONS
  Re-irradiation using proton beam therapy combined with weekly intra-arterial chemotherapy improved OS and local control rates compared with other treatment modalities and could become a new treatment modality for patients with recurrent oral cancer.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.|Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Hayashi
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Mitsudo
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
authors.forename: Kanako
authors.initials: K
authors.lastname: Kimura
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamaguchi
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ono
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Azami
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Kanako
authors.initials: K
authors.lastname: Takayama
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Hirose
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Yabuuchi
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
authors.forename: Motohisa
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
authors.forename: Yoshiomi
authors.initials: Y
authors.lastname: Hatayama
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kikuchi
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Wada
authors.affiliation: Department of Radiology, Ise Red Cross Hospital, Ise, Japan.
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Fuwa
authors.affiliation: Department of Radiation Oncology, Southern Tohoku Proton Therapy Center, Koriyama, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Hareyama
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Iwai
authors.initials: I
authors.lastname: Tohnai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000532:radiotherapy*; D061766:Proton Therapy / Q000009:adverse effects / Q000379:methods*; D000069475:Re-Irradiation / Q000009:adverse effects / Q000379:methods; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D002945:Cisplatin
keywords: head and neck cancer; intra-arterial chemotherapy; oral cancer; proton beam therapy; re-irradiation