title: Is current clinical practice modified about intraoperative breast irradiation?
abstract: After the results obtained in the two randomized clinical trial, the ELIOT trial and the TARGIT-A trial, a heated debate is going on concerning the question of applying intraoperative radiotherapy (IORT) instead of postoperative whole breast irradiation (WBI) after breast conservative treatment. Currently, many centers are applying the IORT following the strict selection criteria dictated by the working groups American Society for Radiation Oncology (ASTRO) and Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) and monitoring the oncological outcome together with radiation toxicity on breast tissue. The clinical experience of the Geneva University Hospital regarding the use of the Intrabeam system is evaluated and compared with current evidences.
authors.affiliation: 1Plastic and Reconstructive Surgery, SS. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy;
authors.forename: Michela
authors.initials: M
authors.lastname: Massa
authors.affiliation: 2Plastic and Reconstructive Surgery, IRCCS AOU San Martino-IST, National Institute of Cancer Research, L.go Rosanna Benzi 10, 16132, Genoa, Italy;
authors.forename: Simonetta
authors.initials: S
authors.lastname: Franchelli
authors.affiliation: 1Plastic and Reconstructive Surgery, SS. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy;
authors.forename: Renzo
authors.initials: R
authors.lastname: Panizza
authors.affiliation: 3Diagnostic Mammography Department, IRCCS AOU San Martino-IST, National Institute of Cancer Research, L.go Rosanna Benzi 10, 16132, Genoa, Italy.
authors.forename: Tiberio
authors.initials: T
authors.lastname: Massa
keywords: Breast cancer; intraoperative radiotherapy (IORT); radiation toxicity