title: Taxanes in the Treatment of Advanced Gastric Cancer.
abstract: Although rapid advances in treatment options have improved the prognosis of advanced gastric cancer (AGC), it remains a major public health problem and the second leading cause of cancer-related deaths in the world. Taxanes (paclitaxel and docetaxel) are microtubule stabilizing agents that inhibit the process of cell division, and have shown antitumor activity in the treatment of AGC as a single or combination chemotherapy. Accordingly, this review focuses on the efficacy and tolerability of taxanes in the first- or second-line chemotherapy setting for AGC.
authors.affiliation: Department of Oncology/Hematology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine, Kyungpook National University Cancer Research Institute, 807 Hogukno, buk-gu, Daegu 41404, Korea. bwkang@knu.ac.kr.
authors.forename: Byung Woog
authors.initials: BW
authors.lastname: Kang
authors.affiliation: Department of Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41494, Korea. kok007@hanmail.net.
authors.forename: Oh-Kyoung
authors.initials: OK
authors.lastname: Kwon
authors.affiliation: Department of Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41494, Korea. hychung@knu.ac.kr.
authors.forename: Ho Young
authors.initials: HY
authors.lastname: Chung
authors.affiliation: Department of Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41494, Korea. wyu@knu.ac.kr.
authors.forename: Wansik
authors.initials: W
authors.lastname: Yu
authors.affiliation: Department of Oncology/Hematology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine, Kyungpook National University Cancer Research Institute, 807 Hogukno, buk-gu, Daegu 41404, Korea. jkk21c@knu.ac.kr.
authors.forename: Jong Gwang
authors.initials: JG
authors.lastname: Kim
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D000077143:Docetaxel; D006801:Humans; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D043823:Taxoids / Q000627:therapeutic use*
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel
keywords: chemotherapy; docetaxel; gastric cancer; paclitaxel; taxanes