title: Synthesis of novel fused quinazolinone derivatives.
abstract: A four-step synthetic route was developed for the synthesis of novel fused quinazolinones, quinazolino[3,4-a]quinazolinones, and isoinodolo[2,1-a]quinazolino[1,2-c]quinazolineones. Reaction of isatoic anhydride and different amines gave various 2-aminobenzamides. Then, reaction of 2-aminobenzamides with 2-nitrobenzaldehyde followed by the reduction of nitro group afforded 2-(2-aminophenyl)-3-aryl-2,3-dihydroquinazolin-4(1H)-one derivatives. Finally, reaction of the latter compounds with aromatic aldehydes or 2-formylbenzoic acid led to the formation of the corresponding products.
authors.affiliation: Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mahdavi
authors.affiliation: School of Chemistry, College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Lotfi
authors.affiliation: Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.|Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mina
authors.initials: M
authors.lastname: Saeedi
authors.affiliation: School of Chemistry, College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Kianmehr
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran. shafieea@tums.ac.ir.
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D015394:Molecular Structure; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D052999:Quinazolinones
keywords: Cyclization; Heterocycles; Isatoic anhydride; Isoinodolo[2, 1-a]quinazolino[1, 2-c]quinazolineones; Quinazolino[3, 4-a]quinazolinones; Quinazolinone