title: Potential Effects of Nonsteroidal Anti-Inflammatory Drugs in the Prevention and Treatment of Type 2 Diabetes Mellitus.
abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of heterogeneous drugs largely known for their anti-inflammatory, antipyretic, and analgesic effects, which are met by means of the inhibition of the cyclooxygenase (COX) enzymes. Even when their use in patients with diabetes mellitus is limited due to relevant adverse events, some pharmacological and metabolic effects of NSAIDs have been further studied to be potentially beneficial in the prevention and/or treatment of diabetic subjects. Effects on endogenous glucose production, peripheral insulin resistance, pancreatic islet, and systemic inflammation and the insulin clearance have been reported. In this article, we overview the scientific literature of the last 5 years regarding the potential effects of NSAID treatment on diabetes prevention/treatment. The selected papers showed information in both humans and animal models. Furthermore, we included papers that suggest new areas for further investigation, and we discussed our own suggestions on this matter.
authors.affiliation: 1 Department of Pharmacology, School of Medicine, Instituto Universitario CEMIC, Buenos Aires, Argentina.
authors.forename: Pamela Natalia
authors.initials: PN
authors.lastname: Bellucci
authors.affiliation: 1 Department of Pharmacology, School of Medicine, Instituto Universitario CEMIC, Buenos Aires, Argentina.
authors.forename: María Florencia
authors.initials: MF
authors.lastname: González Bagnes
authors.affiliation: 2 Second Chair of Pharmacology - Department of Pharmacology and Toxicology, School of Medicine, Universidad de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Di Girolamo
authors.affiliation: 1 Department of Pharmacology, School of Medicine, Instituto Universitario CEMIC, Buenos Aires, Argentina.
authors.forename: Claudio Daniel
authors.initials: CD
authors.lastname: González
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis / Q000517:prevention & control*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000188:drug therapy; D007333:Insulin Resistance / Q000502:physiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001786:Blood Glucose; D052246:Cyclooxygenase 2 Inhibitors
keywords: COX inhibition; NSAIDs; diabetes; inflammation; salsalate