title: Coping with the metabolic stress of leaving home.
abstract: Detachment from extracellular matrix causes metabolic defects that transformed cells must overcome in order to survive and proliferate outside of their normal niche. A recent report from Jiang et al. published in Nature describes how cancer cells grown in suspension utilize reductive carboxylation of glutamine to transfer reducing power from the cytosol to mitochondria to detoxify reactive oxygen species and promote anchorage-independent growth and survival.
authors.affiliation: Department of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Coloff
authors.affiliation: Department of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Joan S
authors.initials: JS
authors.lastname: Brugge
mesh_terms: D000223:Adaptation, Psychological; D006706:Homeostasis; D008928:Mitochondria; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species; D013312:Stress, Physiological
chemical_list: D017382:Reactive Oxygen Species