title: Design, synthesis and antifungal activity of novel furancarboxamide derivatives.
abstract: Twenty-seven novel furancarboxamide derivatives with a diphenyl ether moiety were synthesized and evaluated for their antifungal activity against Rhizoctonia solani, Botrytis cirerea, Valsa mali and Sphaceloma ampelimum. Antifungal bioassay results indicated that most compounds had good or excellent fungicidal activities for R. solani and S. ampelimum at 20 mg L(-1). Among synthesized compounds, compound 18e showed a greater inhibitory effect against S. ampelimum, with half maximal effective concentration (EC50) values of 0.020 mg L(-1). This strong activity rivals currently used commercial fungicides, such as Boscalid and Carbendazim, and has great potential as a lead compound for future development of novel fungicides.
authors.affiliation: Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wen
authors.affiliation: Key Laboratory of Bio-Resource and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610064, China. Electronic address: jinhong@scu.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Jin
authors.affiliation: Key Laboratory of Bio-Resource and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610064, China. Electronic address: taoke@scu.edu.cn.
authors.forename: Ke
authors.initials: K
authors.lastname: Tao
authors.affiliation: Key Laboratory of Bio-Resource and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610064, China.
authors.forename: Taiping
authors.initials: T
authors.lastname: Hou
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D005663:Furans / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D005663:Furans
keywords: Antifungal activity; Diphenyl ether; Furancarboxamides; Synthesis