title: Investigation of apoptotic events at molecular level induced by SERS guided targeted theranostic nanoprobe.
abstract: Herein, we have examined distinctive structural and functional variations of cellular components during apoptotic cell death induced by a targeted theranostic nanoprobe, MMP-SQ@GNR@LAH-DOX, which acted as a SERS "on/off" probe in the presence of a MMP protease and executed synergistic photothermal chemotherapy, as reflected by the SERS fingerprinting, corresponding to the phosphodiester backbone of DNA.
authors.affiliation: CSIR-National Institute for Interdisciplinary Science & Technology (NIIST), Chemical Science & Technology Division (CSTD), Organic chemistry section, Industrial Estate, Thiruvananthapuram 695019, Kerala, India. kkmaiti@niist.res.in and Academy of Scientific and Innovative Research (AcSIR) - CSIR-NIIST, Thiruvananthapuram, India.
authors.forename: Nisha
authors.initials: N
authors.lastname: Narayanan
authors.affiliation: Biophotonics and Imaging Laboratory, Bio Medical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram 695012, Kerala, India.
authors.forename: Lakshmi V
authors.initials: LV
authors.lastname: Nair
authors.affiliation: CSIR-National Institute for Interdisciplinary Science & Technology (NIIST), Chemical Science & Technology Division (CSTD), Organic chemistry section, Industrial Estate, Thiruvananthapuram 695019, Kerala, India. kkmaiti@niist.res.in and Academy of Scientific and Innovative Research (AcSIR) - CSIR-NIIST, Thiruvananthapuram, India.
authors.forename: Varsha
authors.initials: V
authors.lastname: Karunakaran
authors.affiliation: CSIR-National Institute for Interdisciplinary Science & Technology (NIIST), Chemical Science & Technology Division (CSTD), Organic chemistry section, Industrial Estate, Thiruvananthapuram 695019, Kerala, India. kkmaiti@niist.res.in.
authors.forename: Manu M
authors.initials: MM
authors.lastname: Joseph
authors.affiliation: CSIR-National Institute for Interdisciplinary Science & Technology (NIIST), Chemical Science & Technology Division (CSTD), Organic chemistry section, Industrial Estate, Thiruvananthapuram 695019, Kerala, India. kkmaiti@niist.res.in and Academy of Scientific and Innovative Research (AcSIR) - CSIR-NIIST, Thiruvananthapuram, India.
authors.forename: Jyothi B
authors.initials: JB
authors.lastname: Nair
authors.affiliation: CSIR-National Institute for Interdisciplinary Science & Technology (NIIST), Chemical Science & Technology Division (CSTD), Organic chemistry section, Industrial Estate, Thiruvananthapuram 695019, Kerala, India. kkmaiti@niist.res.in.
authors.forename: Ramya A
authors.initials: RA
authors.lastname: N
authors.affiliation: Biophotonics and Imaging Laboratory, Bio Medical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram 695012, Kerala, India.
authors.forename: Ramapurath S
authors.initials: RS
authors.lastname: Jayasree
authors.affiliation: CSIR-National Institute for Interdisciplinary Science & Technology (NIIST), Chemical Science & Technology Division (CSTD), Organic chemistry section, Industrial Estate, Thiruvananthapuram 695019, Kerala, India. kkmaiti@niist.res.in and Academy of Scientific and Innovative Research (AcSIR) - CSIR-NIIST, Thiruvananthapuram, India.
authors.forename: Kaustabh Kumar
authors.initials: KK
authors.lastname: Maiti