title: Association between the IL7R T244I polymorphism and multiple sclerosis risk: a meta analysis.
abstract: The aim of this study was to explore the association between the IL7R T244I polymorphism (rs6897932) and susceptibility of multiple sclerosis (MS). A comprehensive literature search for relevant studies was conducted on Google scholar, PubMed, the Chinese National Knowledge Infrastructure (CNKI) and the Chinese Biomedical Literature Database (CBM). This meta-analysis was performed using the STATA 11.0 software and the pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated. Seventeen case-control studies were included in this meta-analysis. In total, 17 articles provided data for 15,270 cases and 17,971 controls. The results showed significant association between the IL7R T244I polymorphism and susceptibility to MS (OR = 1.125, 95 % CI: 1.016-1.245, p = 0.024 for C vs. T; OR = 1.176, 95 % CI: 1.078-1.282, p < 0.001 for CC + CT vs. TT; OR = 1.243, 95 % CI: 1.088-1.421, p = 0.001 for CC vs. TT). Stratified analysis of ethnicities also showed significant association in Europeans. However, no association was found in Asians. This study suggested that the IL7R C allele was associated with an increased risk of MS and larger-scale studies of populations are needed to explore the roles played by the IL7R T244I polymorphism during the pathogenesis of MS.
authors.affiliation: School of Integrated Traditional and Western Medicine, Anhui College of Chinese Traditional Medicine, Hefei, China.
authors.forename: Song
authors.initials: S
authors.lastname: Wu
authors.affiliation: School of Integrated Traditional and Western Medicine, Anhui College of Chinese Traditional Medicine, Hefei, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: School of Integrated Traditional and Western Medicine, Anhui College of Chinese Traditional Medicine, Hefei, China.
authors.forename: Ji-Min
authors.initials: JM
authors.lastname: Zhu
authors.affiliation: School of Integrated Traditional and Western Medicine, Anhui College of Chinese Traditional Medicine, Hefei, China.
authors.forename: Ming-Rui
authors.initials: MR
authors.lastname: Wang
authors.affiliation: School of Integrated Traditional and Western Medicine, Anhui College of Chinese Traditional Medicine, Hefei, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Gynaecology and Obstetrics, First Affiliated Hospital of Anhui Medical University, Hefei, 230032, Anhui, China. chinasunmeiguo@126.com.
authors.forename: Mei-Guo
authors.initials: MG
authors.lastname: Sun
mesh_terms: D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015851:Interleukin-7 / Q000235:genetics*; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: C508605:IL7 protein, human; D015851:Interleukin-7
keywords: IL7R; MS; Meta-analysis; Polymorphism