title: Review - Lichen-Associated Bacteria as a Hot Spot of Chemodiversity: Focus on Uncialamycin, a Promising Compound for Future Medicinal Applications.
abstract: This review presents the state of knowledge on the medicinal potential of bacteria associated with lichens. In fact, besides the classical symbiotic partners (photobiont and mycobiont) forming the lichen thallus, associated bacteria have been recently described as a third partner. Various studies demonstrated the diversity of these communities with a predominance of Alphaproteobacteria. Bacterial groups more relevant for secondary metabolite synthesis have also been revealed. This article summarizes studies reporting the abilities of these communities to produce metabolites with relevant bioactivities. The biotechnological interest of these bacteria for drug discovery is highlighted regarding the production of compounds with therapeutic potential. Special focus is given to the synthesis of the most promising compound, uncialamycin, a potent enediyne isolated from a Streptomyces sp. associated with Cladonia uncialis.
authors.affiliation: UMR CNRS 6226, Institut des Sciences Chimiques de Rennes, Equipe PNSCM "Produits naturels - Synthèses - Chimie Médicinale", UFR Sciences Pharmaceutiques et Biologiques, Univ. Rennes 1, Université Européenne de Bretagne, Rennes, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Parrot
authors.affiliation: UMR CNRS 6226, Institut des Sciences Chimiques de Rennes, Equipe PNSCM "Produits naturels - Synthèses - Chimie Médicinale", UFR Sciences Pharmaceutiques et Biologiques, Univ. Rennes 1, Université Européenne de Bretagne, Rennes, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Legrave
authors.affiliation: UMR CNRS 6226, Institut des Sciences Chimiques de Rennes, Equipe PNSCM "Produits naturels - Synthèses - Chimie Médicinale", UFR Sciences Pharmaceutiques et Biologiques, Univ. Rennes 1, Université Européenne de Bretagne, Rennes, France.
authors.forename: David
authors.initials: D
authors.lastname: Delmail
authors.affiliation: Institut für Pflanzenwissenschaften, Karl-Franzens-Universität, Graz, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Grube
authors.affiliation: Sorbonne Universités, UPMC Univ. Paris 06, CNRS, Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Observatoire Océanologique, F-66650 Banyuls/Mer, France.
authors.forename: Marcelino
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: UMR CNRS 6226, Institut des Sciences Chimiques de Rennes, Equipe PNSCM "Produits naturels - Synthèses - Chimie Médicinale", UFR Sciences Pharmaceutiques et Biologiques, Univ. Rennes 1, Université Européenne de Bretagne, Rennes, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Tomasi
mesh_terms: D020561:Alphaproteobacteria / Q000737:chemistry* / Q000302:isolation & purification; D000880:Anthraquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D055808:Drug Discovery; D008011:Lichens / Q000382:microbiology*; D013302:Streptomyces / Q000737:chemistry
chemical_list: D000880:Anthraquinones; C512009:uncialamycin