title: Polymorphisms Associated with Increased Cardiovascular Risk in the General Population do not Predict Acute Events in Hemodialysis Patients.
abstract: BACKGROUND
  Cardiovascular diseases are the leading cause of morbidity and mortality in hemodialysis patients (HP). The aim of the study was to analyze a series of polymorphisms (known to be associated with increased cardiovascular risk in the general population) in HP, in order to better understand the mechanisms of cardiovascular disease and to find new prevention strategies.
  
  
  METHODS
  102 hemodialysis patients were investigated for polymorphisms associated with increased cardiovascular risk in unselected population (FV Leiden R506Q; FV H1299R; FII G20210A; PAI-1 var 4G/5G; GpIIIA T1565C; FXIII var G/T; β-FIBRINOGENO var G/A; ACE I/D; AGT var M/T; ATR-1A1166C; APOE T112C; APOE T158C; MTHFR C677T; MTHFR A1298C; CBS 844ins68).
  
  
  RESULTS
  No difference was observed in the prevalence of the analysed polymorphisms between HP and Caucasian unselected population, with the exception of FV H1299R, PAI-1 (4G/5G), and Factor XIII V34L, which were significantly higher in HP. However none of the genetic factors analysed was associated in HP with the cardiovascular events (non-fatal and fatal) recorded at the time of recruitment or during the eighteen months -follow up.
  
  
  CONCLUSIONS
  In HP, the traditional genetic risk factors for cardiovascular disease are not able to predict acute cardiac events, peripheral vascular events, and cerebral vascular events recorded during a follow up period of eighteen months.
authors.forename: Roberta
authors.initials: R
authors.lastname: Rolla
authors.forename: Andreana
authors.initials: A
authors.lastname: De Mauri
authors.forename: Matteo
authors.initials: M
authors.lastname: Vidali
authors.forename: Ambra
authors.initials: A
authors.lastname: Valsesia
authors.forename: Doriana
authors.initials: D
authors.lastname: Chiarinotti
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bellomo
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology*; D005165:Factor V / Q000235:genetics; D005176:Factor XIII / Q000235:genetics; D005260:Female; D006801:Humans; D039661:Integrin beta3 / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011516:Prothrombin / Q000235:genetics; D006435:Renal Dialysis
chemical_list: D039661:Integrin beta3; D005165:Factor V; D011516:Prothrombin; D005176:Factor XIII