title: Hypromellose succinate-crosslinked chitosan hydrogel films for potential wound dressing.
abstract: The objective of this study was to develop novel hydrogel films based on carboxyl-modified hypromellose-crosslinked chitosan for potential wound dressing. Hypromellose (HPMC) was grafted with succinic acid to yield hypromellose succinate (HPMCS), and then the reinforced hydrogel films of HPMCS-crosslinked chitosan (HPMCS-CS) were prepared through amide bond formation using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N- hydroxysuccinimide (NHS) as a catalyst. Compared to that of blend film, mechanical properties of HPMCS-CS hydrogel films were significantly enhanced both in dry and swollen state. To assess the applicability of HPMCS-CS hydrogel films as wound dressing, the swelling behavior, water vapor transmission rate (WVTR), oxygen permeability, biocompatibility (cytotoxicity and hemolysis), in vitro drug release and bactericidal properties were analyzed. The results indicated that HPMCS-CS hydrogel films with good biocompatibility possess high swelling ratio, proper WVTR, and oxygen permeability, which might accelerate tissue regeneration. Meanwhile, gentamycin sulfate release from drug-loaded HPMCS-CS hydrogel films were sustained, which would help to protect wound from infection.
authors.affiliation: Engineering Research Center for Biomedical Materials, School of Life Science, Anhui University, 111 Jiulong Road, Hefei, Anhui Province, 230601, PR China; College of Chemistry and Bio-Engineering, Yichun University, Yichun 336000, PR China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: School of Pharmaceutical Science, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu Province, 214122, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Engineering Research Center for Biomedical Materials, School of Life Science, Anhui University, 111 Jiulong Road, Hefei, Anhui Province, 230601, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Engineering Research Center for Biomedical Materials, School of Life Science, Anhui University, 111 Jiulong Road, Hefei, Anhui Province, 230601, PR China; School of Pharmaceutical Science, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu Province, 214122, PR China. Electronic address: tangrp99@iccas.ac.cn.
authors.forename: Rupei
authors.initials: R
authors.lastname: Tang
authors.affiliation: School of Pharmaceutical Science, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu Province, 214122, PR China.
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Engineering Research Center for Biomedical Materials, School of Life Science, Anhui University, 111 Jiulong Road, Hefei, Anhui Province, 230601, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D001458:Bandages / Q000382:microbiology; D049109:Cell Proliferation / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D065546:Drug Liberation; D004926:Escherichia coli / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D020100:Hydrogels / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D065347:Hypromellose Derivatives / Q000737:chemistry*; D055595:Mechanical Phenomena; D051379:Mice; D041681:NIH 3T3 Cells; D010100:Oxygen / Q000737:chemistry; D010539:Permeability; D013211:Staphylococcus aureus / Q000187:drug effects; D013227:Steam; D013387:Succinic Anhydrides / Q000737:chemistry; D014945:Wound Healing
chemical_list: D020100:Hydrogels; D013227:Steam; D013387:Succinic Anhydrides; D065347:Hypromellose Derivatives; C031801:succinic anhydride; D048271:Chitosan; D010100:Oxygen
keywords: Chitosan; Hydrogel; Wound dressing