title: Risk and survival outcomes of radiation-induced CNS tumors.
abstract: Patients treated with cranial radiation are at risk of developing secondary CNS tumors. Understanding the incidence, treatment, and long-term outcomes of radiation-induced CNS tumors plays a role in clinical decision-making and patient education. Additionally, as meningiomas and pituitary tumors have been detected at increasing rates across all ages and may potentially be treated with radiation, it is important to know and communicate the risk of secondary tumors in children and adults. After conducting an extensive literature search, we identified publications that report incidence and long-term outcomes of radiation-induced CNS tumors. We reviewed 14 studies in children, which reported that radiation confers a 7- to 10-fold increase in subsequent CNS tumors, with a 20-year cumulative incidence ranging from 1.03 to 28.9 %. The latency period for secondary tumors ranged from 5.5 to 30 years, with gliomas developing in 5-10 years and meningiomas developing around 15 years after radiation. We also reviewed seven studies in adults, where the two strongest studies showed no increased risk while the remaining studies found a higher risk compared to the general population. The latency period for secondary CNS tumors in adults ranged from 5 to 34 years. Treatment and long-term outcomes of radiation-induced CNS tumors have been documented in four case series, which did not conclusively demonstrate that secondary CNS tumors fared worse than primary CNS tumors. Radiation-induced CNS tumors remain a rare occurrence that should not by itself impede radiation treatment. Additional investigation is needed on the risk of radiation-induced tumors in adults and the long-term outcomes of these tumors.
authors.affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Jessica W
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Stich Radiation Oncology, Weill Cornell Medical College/New York-Presbyterian Hospital, 525 E. 68th Street at York Avenue, New York, NY, 10065, USA. gaw9008@med.cornell.edu.|Department of Neurosurgery, Weill Cornell Medical College/New York-Presbyterian Hospital, 525 East 68th Street, New York, NY, 10065, USA. gaw9008@med.cornell.edu.
authors.forename: A Gabriella
authors.initials: AG
authors.lastname: Wernicke
mesh_terms: D016543:Central Nervous System Neoplasms / Q000453:epidemiology*; D016371:Cranial Irradiation / Q000009:adverse effects; D018572:Disease-Free Survival; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Brain tumor; CNS tumor; Radiation-induced tumor; Secondary tumor