title: De novo degenerative lumbar scoliosis: a systematic review of prognostic factors for curve progression.
abstract: To identify prognostic factors for curve progression in de novo degenerative lumbar scoliosis (DNDLS) by performing a systematic review of the literature.
  
  
  
  Studies were selected for inclusion following a systematic search in the bibliographic databases PubMed and EMBASE prior to September 2015 and hand searches of the reference lists of retrieved articles. Two authors independently assessed methodological quality. Data were extracted and presented according to a best evidence synthesis.
  
  
  
  The literature search generated a total of 2696 references. After removing duplicates and articles that did not meet inclusion criteria, 12 studies were included. Due to the lack of statistical analyses, pooling of data was not possible. Strong evidence indicates that increasing intervertebral disk degeneration, lateral vertebral translation ≥6 mm, and an intercrest line through L5 (rather than L4) are associated with DNDLS curve progression. Moderate evidence suggests that apical vertebral rotation Grade II or III is associated with curve progression. For the majority of other prognostic factors, we found limited, conflicting, or inconclusive evidence. Osteoporosis, a coronal Cobb angle <30°, lumbar lordosis, lateral osteophytes difference of ≥5 mm, and degenerative spondylolisthesis have not been shown to be risk factors. Clinical risk factors for progression were not identified.
  
  
  
  This review shows strong evidence that increased intervertebral disk degeneration, an intercrest line through L5, and apical lateral vertebral translation ≥6 mm are associated with DNDLS curve progression. Moderate evidence was found for apical vertebral rotation (Grade II/III) as a risk factor for curve progression. These results, however, may not be directly applicable to the individual patient.
authors.affiliation: Department of Orthopaedic Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
authors.forename: Sayf S A
authors.initials: SS
authors.lastname: Faraj
authors.affiliation: Department of Orthopaedic Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
authors.forename: Roderick M
authors.initials: RM
authors.lastname: Holewijn
authors.affiliation: Department of Orthopaedic Surgery, Sint Maartenskliniek, Nijmegen, The Netherlands.
authors.forename: Miranda L
authors.initials: ML
authors.lastname: van Hooff
authors.affiliation: Department of Orthopaedic Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.|Department of Orthopaedic Surgery, Sint Maartenskliniek, Nijmegen, The Netherlands.
authors.forename: Marinus
authors.initials: M
authors.lastname: de Kleuver
authors.affiliation: Spine Unit, Hospital Vall d'Hebron, Barcelona, Spain.
authors.forename: Ferran
authors.initials: F
authors.lastname: Pellisé
authors.affiliation: Department of Orthopaedic Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. t.haanstra@vumc.nl.
authors.forename: Tsjitske M
authors.initials: TM
authors.lastname: Haanstra
mesh_terms: D018450:Disease Progression; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000000981:diagnostic imaging* / Q000453:epidemiology; D008141:Lordosis; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D054850:Osteophyte / Q000000981:diagnostic imaging / Q000453:epidemiology; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000453:epidemiology; D011379:Prognosis; D012307:Risk Factors; D012399:Rotation; D012600:Scoliosis / Q000000981:diagnostic imaging* / Q000453:epidemiology; D013168:Spondylolisthesis / Q000000981:diagnostic imaging / Q000453:epidemiology
keywords: Adult’s scoliosis; Curve progression; De novo degenerative lumbar scoliosis; Prognostic factors; Systematic review