title: Endometriosis Affects Oocyte Morphology in Intracytoplasmic Sperm Injection Cycles?
abstract: OBJECTIVE
  To identify associations between presence of endometriosis and oocyte defects, embryo developmental potential, and cycle outcomes.
  
  
  METHODS
  This study looked into the impact of endometriosis on oocyte and embryo quality, and blastocyst formation probability. Endometriosis was also correlated with cycle characteristics. In order to avoid age-related bias, in the first analysis only patients aged 36 years or younger were included, and the cycles were split into endometriosis infertility cycles (n=431; 3172 oocytes) and other cycles (n=2510; 24480 oocytes).
  
  
  RESULTS
  The number of retrieved oocytes (10.6±21.2 vs. 14.6±21.1, P<0.001), oocyte yield (68.1±20.0% vs. 70.6±19.6%, P=0.015), and embryos obtained (6.1±4.43 vs. 7.8±5.12, P<0.001) were lower among patients with endometriosis. Implantation rates (28.1%±38.9% vs. 33.9±42.7, P<0.001) were lower among patients with endometriosis, but fertilization, pregnancy, miscarriage and cycle cancelation rates were not different. There was a significant increase in the incidence of extra-cytoplasmic, but not intra-cytoplasmic, oocyte defects among patients with endometriosis. The quality of embryos (45.3% vs. 47.3%, P=0.037) collected from patients with endometriosis was lower, but blastocyst formation rates were unaltered.
  
  
  CONCLUSIONS
  A possible explanation for the lower implantation rates seen in patients with endometriosis is the poorer quality of the oocytes and embryos observed in this group of patients.
authors.affiliation: Fertility - Medical Group - São Paulo - Brasil.
authors.forename: Edson
authors.initials: E
authors.lastname: Borges
authors.affiliation: Fertility - Medical Group - São Paulo - Brasil.|Disciplina de Urologia, Área de Reprodução Humana, Depto de Cirurgia, Universidade Federal de São Paulo.
authors.forename: Daniela P A F
authors.initials: DP
authors.lastname: Braga
authors.affiliation: Instituto Sapientiae - Centro de Estudos e Pesquisa em Reprodução Assistida.
authors.forename: Amanda S
authors.initials: AS
authors.lastname: Setti
authors.affiliation: Fertility - Medical Group - São Paulo - Brasil.
authors.forename: Livia S
authors.initials: LS
authors.lastname: Vingris
authors.affiliation: Fertility - Medical Group - São Paulo - Brasil.
authors.forename: Rita Cassia S
authors.initials: RC
authors.lastname: Figueira
authors.affiliation: Fertility - Medical Group - São Paulo - Brasil.
authors.forename: Assumpto
authors.initials: A
authors.lastname: Iaconelli
keywords: Embryos; Endometriosis; ICSI; Implantation; Oocytes