title: Asynchronous Detected Disappearance of the Pro-nuclei by Time-Lapse X Embryonic Development.
abstract: OBJECTIVE
  To investigate whether pro-nuclei disappearance synchronicity would have something to do with blastomere cleavage time up to D3 (timeline) and if it would be associated with the appearance of embryo abnormalities.
  
  
  METHODS
  The sample of the present study was designed with 100 embryos (n = 100). With the aid of an embryonic analysis equipment: Time-Lapse, we studied embryonic morphokinetics from the zygote stage to D3.
  
  
  RESULTS
  When there was no pronuclei synchronous disappearance, 30.8% underwent normal cleavage, whereas when there was pronuclei synchronous disappearance, 44.8% had normal cleavage. When there was no pronuclei synchronous disappearance, 46.2% had some type of abnormality, whereas when there was pronuclei synchronous disappearance, 56.3% had some kind of abnormality.
  
  
  CONCLUSIONS
  Although the statistical results were not significant, we believe that with a larger sample size we could state with higher reliability, that the pro-nuclei synchronous disappearance analysis may, in the near future, indicate higher embryo quality.
authors.affiliation: Embryolife Instituto de Medicina Reprodutiva, São José dos Campos/SP.
authors.forename: Guilherme Rios Franco
authors.initials: GR
authors.lastname: Rosário
authors.affiliation: Embryolife Instituto de Medicina Reprodutiva, São José dos Campos/SP.
authors.forename: Antônio Carlos Costa
authors.initials: AC
authors.lastname: Franco
authors.affiliation: Embryolife Instituto de Medicina Reprodutiva, São José dos Campos/SP.
authors.forename: Adriana Valério da
authors.initials: AV
authors.lastname: Silva
keywords: Abnormalities; Cleavage; Embryo; In vitro fertilization; Time-Lapse