title: Intravitreal Bevacizumab for Treatment of Central Serous Chorioretinopathy.
abstract: OBJECTIVE
  To compare the outcomes of treatment with intravitreal bevacizumab (IVB) versus observation in central serous chorioretinopathy (CSCR).
  
  
  METHODS
  In a retrospective comparative study, records of 45 patients with CSCR were reviewed. Twenty-two patients received IVB (1.25 mg/0.05 ml) while 23 subjects were observed. All subjects underwent measurement of best corrected visual acuity (BCVA) and intraocular pressure (IOP), dilated fundus examination and optical coherence tomography (OCT) imaging at baseline and follow up visits. Outcome measures included central macular thickness (CMT) and BCVA in logarithm of minimum angle of resolution (logMAR) notations.
  
  
  RESULTS
  Mean age was 44.1 ± 9.3 (range: 24 to 64) years and mean follow-up period was 10.4 ± 11.2 (range: 3 to 43; median: 6) months. All patients demonstrated resolution of neurosensory detachment and improvement in visual acuity. At final visit, there was no significant difference in mean CMT between the IVB and observation groups (275 vs 284 μm, P> 0.05). Mean baseline logMAR visual acuity was 0.38 ± 0.24 in the IVB group which improved to 0.24 ± 0.31 at final follow-up (P = 0.011); mean baseline logMAR visual acuity was 0.42 ± 0.28 in the observation group and improved to 0.12 ± 0.18 (P = 0.001). Visual improvement was more marked in the observation group (0.30 vs 0.14 logMAR, P< 0.05) and mean final visual acuity was also significantly better (P = 0.05).
  
  
  CONCLUSIONS
  There was no significant difference between IVB injection and observation in terms of anatomical outcomes of treatment for CSCR. In terms of visual outcomes, observation was superior to IVB injection.
authors.affiliation: Department of Ophthalmology, Ümraniye Training and Research Hospital, Istanbul, Turkey.
authors.forename: Cihan
authors.initials: C
authors.lastname: Ünlü
authors.affiliation: Department of Ophthalmology, Ümraniye Training and Research Hospital, Istanbul, Turkey.
authors.forename: Gurkan
authors.initials: G
authors.lastname: Erdogan
authors.affiliation: Department of Ophthalmology, Ümraniye Training and Research Hospital, Istanbul, Turkey.
authors.forename: Tugba
authors.initials: T
authors.lastname: Aydogan
authors.affiliation: Department of Ophthalmology, Ümraniye Training and Research Hospital, Istanbul, Turkey.
authors.forename: Betul Ilkay
authors.initials: BI
authors.lastname: Sezgin Akcay
authors.affiliation: Department of Ophthalmology, Ümraniye Training and Research Hospital, Istanbul, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Kardes
authors.affiliation: Department of Ophthalmology, Ümraniye Training and Research Hospital, Istanbul, Turkey.
authors.forename: Gulunay Akcali
authors.initials: GA
authors.lastname: Kiray
authors.affiliation: Department of Ophthalmology, Ümraniye Training and Research Hospital, Istanbul, Turkey.
authors.forename: Tahir Kansu
authors.initials: TK
authors.lastname: Bozkurt
keywords: Central Serous Chorioretinopathy; Intravitreal Bevacizumab (Avastin); Macular Thickness; Observation