title: Gestational dexamethasone alters fetal neuroendocrine axis.
abstract: This study tested whether the maternal transport of dexamethasone (DEXA) may affect the development of the neuroendocrine system. DEXA (0.2mg/kg b.w., subcutaneous injection) was administered to pregnant rats from gestation day (GD) 1-20. In the DEXA-treated group, a decrease in maternal serum thyroxine (T4), triiodothyronine (T3), and increase in thyrotropin (TSH) levels (hypothyroid status) were observed at GDs 15 & 20 with respect to control group. The reverse pattern (hyperthyroid status) was observed in their fetuses at embryonic days (EDs) 15 & 20. Although the maternal body weight was diminished, the weight of the thyroid gland was increased at studied GDs as compared to the control group. The fetal growth retardation, hyperleptinemia, hyperinsulinism, and cytokines distortions (transforming growth factor-beta; TGF-β, tumor necrosis factor-alpha; TNF-α, and interferon-γ; IFN-γ) were noticed at examined EDs if compared to the control group. Alternatively, the maternofetal thyroid dysfunctions due to the maternal DEXA administration attenuated the levels of fetal cerebral norepinephrine (NE) and epinephrine (E), and elevated the levels of dopamine (DA) and 5-hydroxytryptamine (5-HT) at considered days. These alterations were age-dependent and might damage the nerve transmission. Finally, maternal DEXA might act as neuroendocrine disruptor causing dyshormonogenesis and fetal cerebral dysfunction.
authors.affiliation: Division of Anatomy and Embryology, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt. Electronic address: ahmedragab08@gmail.com.
authors.forename: R G
authors.initials: RG
authors.lastname: Ahmed
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016207:Cytokines / Q000819:agonists / Q000097:blood; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D052244:Endocrine Disruptors / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D005317:Fetal Growth Retardation / Q000097:blood / Q000139:chemically induced / Q000276:immunology / Q000473:pathology; D006946:Hyperinsulinism / Q000139:chemically induced / Q000196:embryology / Q000276:immunology / Q000473:pathology; D007037:Hypothyroidism / Q000139:chemically induced* / Q000196:embryology / Q000276:immunology / Q000473:pathology; D007279:Injections, Subcutaneous; D020738:Leptin / Q000819:agonists / Q000097:blood; D008431:Maternal-Fetal Exchange; D009490:Neurosecretory Systems / Q000187:drug effects* / Q000196:embryology; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000187:drug effects / Q000196:embryology / Q000276:immunology / Q000473:pathology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D052244:Endocrine Disruptors; D020738:Leptin; D014284:Triiodothyronine; D003907:Dexamethasone; D013972:Thyrotropin; D013974:Thyroxine
keywords: Cerebrum; Dexamethasone; Fetus; Pregnant rats; Thyroid