title: Percutaneous computed tomography-guided cryoablation for recurrent retroperitoneal soft tissue sarcoma: a study of safety and efficacy.
abstract: OBJECTIVE
  To evaluate the use of computed tomography image-guided percutaneous cryoablation for recurrent retroperitoneal soft tissue sarcomas (RPSs).
  
  
  RESULTS
  Adverse events were limited to grades 1 and 2, included fever (n = 19), local pain (n = 11), emesis (n = 10), frostbite (n = 6), and nerve injury (n = 1). Fever was more frequent in the large tumor group (15.8%) than in small tumor group (1.9%) (P = 0.008). Median PFS and OS were 37.0 ± 7.7 months (range, 4-39 months) and 43.0 ± 5.9 months (range, 6-54 months), respectively. PFS and OS were significantly longer in the small tumor group than in the large tumor group (P = 0.011 and P = 0.015, respectively), but the response rate (82.7% vs. 72.8%, P = 0.240) did not differ significantly. On univariate analysis, tumor size, tumor invasion grade, and distant metastasis were significant prognostic factors for PFS and OS. On multivariate analysis, a tumor size ≥10 cm was an independent negative prognostic factor for PFS and OS after cryoablation (HR: 3.98, 95% CI: 1.27-12.50, P = 0.018 and HR: 4.33, 95% CI: 1.41-13.26, P = 0.010, respectively).
  
  
  METHODS
  Data from 72 patients with recurrent RPSs who underwent percutaneous cryoablation were reviewed retrospectively. The prognostic factors for progression-free survival (PFS), overall survival (OS), and efficacy based on mRECIST criteria were analysis. Adverse events were compared according to tumor size (<10 and ≥10 cm).
  
  
  CONCLUSIONS
  Minimally invasive percutaneous cryoablation was safe and efficacious for recurrent RPSs.
authors.affiliation: Department of Interventional Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Wenzhe
authors.initials: W
authors.lastname: Fan
authors.affiliation: Fuda Cancer Hospital, Guangzhou, China.|Fuda Institute of Cryosurgery for Cancer, Guangzhou, China.
authors.forename: Lizhi
authors.initials: L
authors.lastname: Niu
authors.affiliation: Department of Interventional Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Interventional Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Yingqiang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Interventional Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Xuehua
authors.initials: X
authors.lastname: Yao
authors.affiliation: Department of Interventional Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Tan
authors.affiliation: Department of Interventional Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.|Department of Medical Imaging, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Jianyong
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Interventional Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Jiaping
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003452:Cryosurgery / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005354:Fibrosarcoma / Q000000981:diagnostic imaging / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D007890:Leiomyosarcoma / Q000000981:diagnostic imaging / Q000628:therapy; D008080:Liposarcoma / Q000000981:diagnostic imaging / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D061214:Patient Safety; D011379:Prognosis; D012186:Retroperitoneal Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D012509:Sarcoma / Q000000981:diagnostic imaging / Q000628:therapy*; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: computer tomography; cryoablation; response rate; retroperitoneal sarcoma; survival