title: Synthesis, characterization and bioactivities of N,O-carbonylated chitosan.
abstract: N,O-Carbonylated chitosan derivative (NTCS) was synthesized via oxidation and substitution reaction, respectively. The carboxyethylation of the polysaccharide was identified by Fourier transform infrared (FTIR), (1)H nuclear magnetic resonance (NMR), X-ray diffraction analysis (XRD), Zeta potential measurement and Thermogravimetric analysis (TGA). It is revealed that compared with chitosan (CS), NTCS exhibited an excellent solubility in distilled water, high in vitro bile acid binding capacity, as well as a low viscosity. The in vitro bile acid binding capacity reached 17.21mg/g, which was 4.5-fold higher than that of CS. The results suggest that NTCS may be useful as a potential functional food supplement in food industry or a key ingredient in the pharmaceutical industry. These findings provide important supports for developing new food additive, and expand the scope of application of CS in the food industry.
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Lihu Road 1800, Wuxi, 214122 Jiangsu, People's Republic of China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Lihu Road 1800, Wuxi, 214122 Jiangsu, People's Republic of China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Lihu Road 1800, Wuxi, 214122 Jiangsu, People's Republic of China. Electronic address: yuelin@jiangnan.edu.cn.
authors.forename: Lin
authors.initials: L
authors.lastname: Yue
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Lihu Road 1800, Wuxi, 214122 Jiangsu, People's Republic of China.
authors.forename: Qixing
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Lihu Road 1800, Wuxi, 214122 Jiangsu, People's Republic of China. Electronic address: xiaws@jiangnan.edu.cn.
authors.forename: Wenshui
authors.initials: W
authors.lastname: Xia
mesh_terms: D001647:Bile Acids and Salts / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D005503:Food Additives / Q000737:chemistry*; D019649:Food Industry
chemical_list: D001647:Bile Acids and Salts; D005503:Food Additives; D048271:Chitosan
keywords: Bioactivity; Characterization; Chemical modification