title: Telocytes (interstitial Cajal-like cells) in human Fallopian tubes.
abstract: BACKGROUND
  Telocytes represent a relatively newly discovered population of cells found within the various tissues and organs, including Fallopian tubes. It is presumed that telocytes could serve as a sensor of hormone levels or regulate activity of muscle peristaltic movement.
  
  
  METHODS
  Tissue sections from anatomically different parts of Fallopian tubes of 48 women (age 48.8±9.1) were stained for the expression of five different antigens: c-kit (CD117), CD34, vimentin, podoplanin (D2-40) and Dog-1.
  
  
  RESULTS
  Telocytes form a network associated with the smooth muscle cells. From the mentioned antibodies, only anti-c-kit (CD117) seems to be relatively selective specific to the telocytes, others react also with numerous other cells and tissue structures. Our results when using antibodies against podoplanin and Dog-1 are in dissonance with recent literature - with regards to our results, they are not suitable for detection of telocytes.
  
  
  CONCLUSIONS
  Methods of immunohistochemistry are suitable for identification of telocytes in Fallopian tubes. C-kit (CD117) antigens are useful for routine identification of telocytes in histological sections. This antigen can be combined with CD34 or vimentin in cases of double staining immunohistochemistry.
authors.forename: L
authors.initials: L
authors.lastname: Urban
authors.forename: M
authors.initials: M
authors.lastname: Miko
authors.forename: M
authors.initials: M
authors.lastname: Kajanova
authors.forename: S
authors.initials: S
authors.lastname: Bozikova
authors.forename: H
authors.initials: H
authors.lastname: Mrazova
authors.forename: I
authors.initials: I
authors.lastname: Varga
mesh_terms: D000328:Adult; D000075369:Anoctamin-1; D018952:Antigens, CD34 / Q000378:metabolism; D018118:Chloride Channels / Q000378:metabolism; D005187:Fallopian Tubes / Q000166:cytology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000378:metabolism; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D000067170:Telocytes / Q000166:cytology* / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism; D000098853:Podoplanin
chemical_list: D000075369:Anoctamin-1; D018952:Antigens, CD34; D018118:Chloride Channels; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D019009:Proto-Oncogene Proteins c-kit; D014746:Vimentin; C476213:ANO1 protein, human; C117468:PDPN protein, human; D000098853:Podoplanin
keywords: human Fallopian tubes; interstitial Cajal-like cells; muscle peristaltic movement; telocytes; tissue structures.