title: Creating biomaterials with spatially organized functionality.
abstract: Biomaterials for tissue engineering provide scaffolds to support cells and guide tissue regeneration. Despite significant advances in biomaterials design and fabrication techniques, engineered tissue constructs remain functionally inferior to native tissues. This is largely due to the inability to recreate the complex and dynamic hierarchical organization of the extracellular matrix components, which is intimately linked to a tissue's biological function. This review discusses current state-of-the-art strategies to control the spatial presentation of physical and biochemical cues within a biomaterial to recapitulate native tissue organization and function.
authors.affiliation: Department of Materials Science and Engineering, Lehigh University, Bethlehem, PA 18015, USA Bioengineering Program, Lehigh University, Bethlehem, PA 18015, USA lesley.chow@lehigh.edu.
authors.forename: Lesley W
authors.initials: LW
authors.lastname: Chow
authors.affiliation: Bioengineering Program, Lehigh University, Bethlehem, PA 18015, USA.
authors.forename: Jacob F
authors.initials: JF
authors.lastname: Fischer
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D055598:Chemical Phenomena; D048091:Guided Tissue Regeneration / Q000379:methods; D006801:Humans; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials
keywords: Biomaterials; biomedical; extracellular matrix; regenerative medicine; tissue engineering; translational