title: Impact of Neutrophil to Lymphocyte Ratio (NLR) Index and Its Periprocedural Change (NLRΔ) for Percutaneous Coronary Intervention in Patients With Chronic Total Occlusion.
abstract: We assessed the association between neutrophil to lymphocyte ratio (NLR) and chronic coronary total occlusion (CTO), as well as clinical prognosis of percutaneous coronary intervention (PCI). Patients referred for elective coronary angiography for stable angina pectoris were enrolled, including a CTO (n = 160) and a non-CTO group (n = 160). Neutrophil to lymphocyte ratio on admission and post-PCI was measured, and NLRΔwas defined as the change between the 2 values. Subgroup analysis was performed based on the value of NLRΔ(≥0.5 vs <0.5). Clinical characteristics, angiographic data, and follow-up data were recorded. Compared with the non-CTO group, the total white blood cell count, neutrophil counts, and NLR were significantly higher in the CTO group. In the NLRΔ≥ 0.5 subgroup, the incidence of severe dissection, slow coronary flow, in-stent restenosis (ISR), and major adverse cardiac events (MACEs) was obviously higher. In multivariate analysis, NLRΔwas independently and positively associated with higher risks of ISR and MACE. The NLR could be a potential predictor of CTO, and NLRΔis independently associated with the adverse clinical outcomes in patients who underwent PCI.
authors.affiliation: 1 Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China.
authors.forename: Chenguang
authors.initials: C
authors.lastname: Li
authors.affiliation: 1 Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.affiliation: 2 Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shen
authors.affiliation: 1 Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China.
authors.forename: Rende
authors.initials: R
authors.lastname: Xu
authors.affiliation: 1 Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China.
authors.forename: Zhangwei
authors.initials: Z
authors.lastname: Chen
authors.affiliation: 1 Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Dai
authors.affiliation: 1 Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Lu
authors.affiliation: 1 Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China.
authors.forename: Shufu
authors.initials: S
authors.lastname: Chang
authors.affiliation: 1 Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China.
authors.forename: Juying
authors.initials: J
authors.lastname: Qian
authors.affiliation: 1 Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China.
authors.forename: Xiangfei
authors.initials: X
authors.lastname: Wang
authors.affiliation: 1 Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China.
authors.forename: Junbo
authors.initials: J
authors.lastname: Ge
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000150:complications / Q000188:drug therapy*; D054059:Coronary Occlusion / Q000150:complications / Q000188:drug therapy*; D017558:Elective Surgical Procedures / Q000379:methods; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils / Q000187:drug effects*; D062645:Percutaneous Coronary Intervention / Q000379:methods
keywords: coronary chronic total occlusion; in-stent restenosis; major adverse cardiac events; neutrophil to lymphocyte ratio