title: Photoresponsive surface molecularly imprinted polymer on ZnO nanorods for uric acid detection in physiological fluids.
abstract: A photoresponsive surface molecularly imprinted polymer for uric acid in physiological fluids was fabricated through a facile and effective method using bio-safe and biocompatible ZnO nanorods as a support. The strategy was carried out by introducing double bonds on the surface of the ZnO nanorods with 3-methacryloxypropyltrimethoxysilane. The surface molecularly imprinted polymer on ZnO nanorods was then prepared by surface polymerization using uric acid as template, water-soluble 5-[(4-(methacryloyloxy)phenyl)diazenyl]isophthalic acid as functional monomer, and triethanolamine trimethacryl ester as cross-linker. The surface molecularly imprinted polymer on ZnO nanorods showed good photoresponsive properties, high recognition ability, and fast binding kinetics toward uric acid, with a dissociation constant of 3.22×10(-5)M in aqueous NaH2PO4 buffer at pH=7.0 and a maximal adsorption capacity of 1.45μmolg(-1). Upon alternate irradiation at 365 and 440nm, the surface molecularly imprinted polymer on ZnO nanorods can quantitatively uptake and release uric acid.
authors.affiliation: The Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China; Department of Science and Environmental Studies, The Hong Kong Institute of Education, Hong Kong.
authors.forename: Qian
authors.initials: Q
authors.lastname: Tang
authors.affiliation: The Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
authors.forename: Zai-Yong
authors.initials: ZY
authors.lastname: Li
authors.affiliation: The Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
authors.forename: Yu-Bo
authors.initials: YB
authors.lastname: Wei
authors.affiliation: The Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Yang
authors.affiliation: The Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
authors.forename: Lan-Tao
authors.initials: LT
authors.lastname: Liu
authors.affiliation: The Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China. Electronic address: gongcbtq@swu.edu.cn.
authors.forename: Cheng-Bin
authors.initials: CB
authors.lastname: Gong
authors.affiliation: The Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
authors.forename: Xue-Bing
authors.initials: XB
authors.lastname: Ma
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Hong Kong.
authors.forename: Michael Hon-Wah
authors.initials: MH
authors.lastname: Lam
authors.affiliation: Department of Science and Environmental Studies, The Hong Kong Institute of Education, Hong Kong. Electronic address: cfchow@ied.edu.hk.
authors.forename: Cheuk-Fai
authors.initials: CF
authors.lastname: Chow
mesh_terms: D000327:Adsorption; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry; D054802:Molecular Imprinting; D043942:Nanotubes / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D014527:Uric Acid / Q000032:analysis*; D014867:Water / Q000737:chemistry; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: C542237:3-methacryloxypropyltrimethoxysilane; D008689:Methacrylates; D011108:Polymers; D012821:Silanes; D014867:Water; D014527:Uric Acid; D015034:Zinc Oxide
keywords: Azobenzene; Photoresponsive surface molecularly imprinted polymer; Uric acid; ZnO nanorods