title: The antioxidant activity of some curcuminoids and chalcones.
abstract: The antioxidant properties of the synthetic compound (C1)-(C8), which comprised 7 curcuminoids and a chalcone, were evaluated by two complementary assays, DPPH and β-carotene/linoleic acid. It was found that, in general, the free radical scavenging ability of (C1)-(C8) was concentration-dependent. Compounds (C1) and (C4), which contained (4-OH) phenolic groups, were found to be highly potent antioxidants with higher antioxidant values than BHT suggesting that synthetic curcuminoids are more potent antioxidants than standard antioxidants like BHT. Using β-carotene-linoleic acid assay, only the water-soluble 2, 4,6-trihydroxyphenolic chalcone (C5) showed 85.2 % inhibition of the formation of conjugated dienes reflecting on its potent antioxidant activity.
authors.affiliation: Department of Chemistry, Faculty of Science, Karadeniz Technical University, 61080, Trabzon, Turkey.
authors.forename: Münevver
authors.initials: M
authors.lastname: Sökmen
authors.affiliation: Biomedical Research Centre, Sheffield Hallam University, Sheffield, S1 1WB, UK. m.a.khan@shu.ac.uk.
authors.forename: M
authors.initials: M
authors.lastname: Akram Khan
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D047188:Chalcones / Q000138:chemical synthesis* / Q000494:pharmacology; D003474:Curcumin / Q000138:chemical synthesis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects
chemical_list: D000975:Antioxidants; D047188:Chalcones; D016166:Free Radical Scavengers; D003474:Curcumin
keywords: 2,4,6-trihydroxyphenolic chalcone; Antioxidant activity; Ascorbic acid; Curcuminoids; Diphenylpicrylhydrazyl radical