title: A new irregular monoterpene acetate along with eight known compounds with antifungal potential from the aerial parts of Artemisia incisa Pamp (Asteraceae).
abstract: A new compound named as santolinylol-3-acetate (4-(2-hydroxypropan-2-yl)-2-methylhexa-1,5-dien-3-yl acetate) (3), along with seven known compounds; linoleic acid (1), benzoic acid (2), santolinylol (4), ethyl-(E)-p-hydroxy cinnamate (5), scopoletin (6), esculetin (7) isofraxidin (8) and eupatorin (9), were isolated from the aerial parts (ethanolic extract) of endangered species: Artemisia incisa Pamp (Asteraceae). The compounds' structures were determined through modern spectroscopic techniques, and comparison of data (physicochemical constants) with the literature. The relative stereochemistry of santolinylol-3-acetate (3) was determined by comparing its data of NOESY, and specific rotation with its diol analogue; santolinylol (4), isolated from the same plant; A. incisa. The results of the antifungal activity showed that coumarins are as whole less active compounds. Compounds 3 (25 and 300 μg/mL), and 4 (12.5 and 300 μg/mL), showed good activities against Candida albicans, and Aspergillus flavus, respectively, which justifies A. incisa as a traditional medicine for curing the said fungal infections.
authors.affiliation: a Phytopharmaceutical and Nutraceutical Research Laboratories (PNRL), Institute of Chemical Sciences , University of Peshawar , Peshawar , Pakistan.
authors.forename: Mamoon Ur
authors.initials: MU
authors.lastname: Rashid
authors.affiliation: b Institute of Chemical Sciences , University of Swat , Swat , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Alamzeb
authors.affiliation: c Department of Chemistry , Moin Ud Din University Nehrain Sharif , Azad Kashmir , Pakistan.
authors.forename: Saqib
authors.initials: S
authors.lastname: Ali
authors.affiliation: d Department of Agriculture Chemistry , The Agriculture University Peshawar , Peshawar , Pakistan.
authors.forename: Zafar Ali
authors.initials: ZA
authors.lastname: Shah
authors.affiliation: e Department of Plant Pathology , The Agriculture University Peshawar , Peshawar , Pakistan.
authors.forename: Ishrat
authors.initials: I
authors.lastname: Naz
authors.affiliation: a Phytopharmaceutical and Nutraceutical Research Laboratories (PNRL), Institute of Chemical Sciences , University of Peshawar , Peshawar , Pakistan.
authors.forename: Ashfaq Ahmad
authors.initials: AA
authors.lastname: Khan
authors.affiliation: f Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS) , University of Strathclyde , Glasgow , Scotland, UK.
authors.forename: Dima
authors.initials: D
authors.lastname: Semaan
authors.affiliation: a Phytopharmaceutical and Nutraceutical Research Laboratories (PNRL), Institute of Chemical Sciences , University of Peshawar , Peshawar , Pakistan.
authors.forename: Mohammad Rafiullah
authors.initials: MR
authors.lastname: Khan
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019306:Artemisia / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D039821:Monoterpenes
keywords: Aspergillus flavus; Candida albicans; Irregular monoterpene; Santolinylol-3-aceate