title: Association of Common Variants in MMPs with Periodontitis Risk.
abstract: Background. Matrix metalloproteinases (MMPs) are considered to play an important role during tissue remodeling and extracellular matrix degradation. And functional polymorphisms in MMPs genes have been reported to be associated with the increased risk of periodontitis. Recently, many studies have investigated the association between MMPs polymorphisms and periodontitis risk. However, the results remain inconclusive. In order to quantify the influence of MMPs polymorphisms on the susceptibility to periodontitis, we performed a meta-analysis and systematic review. Results. Overall, this comprehensive meta-analysis included a total of 17 related studies, including 2399 cases and 2002 healthy control subjects. Our results revealed that although studies of the association between MMP-8 -799 C/T variant and the susceptibility to periodontitis have not yielded consistent results, MMP-1 (-1607 1G/2G, -519 A/G, and -422 A/T), MMP-2 (-1575 G/A, -1306 C/T, -790 T/G, and -735 C/T), MMP-3 (-1171 5A/6A), MMP-8 (-381 A/G and +17 C/G), MMP-9 (-1562 C/T and +279 R/Q), and MMP-12 (-357 Asn/Ser), as well as MMP-13 (-77 A/G, 11A/12A) SNPs are not related to periodontitis risk. Conclusions. No association of these common MMPs variants with the susceptibility to periodontitis was found; however, further larger-scale and multiethnic genetic studies on this topic are expected to be conducted to validate our results.
authors.affiliation: Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences and College of Stomatology, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Wenyang
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Forensic Medicine, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences and College of Stomatology, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Singh
authors.affiliation: Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences and College of Stomatology, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Deepal Haresh
authors.initials: DH
authors.lastname: Ajmera
authors.affiliation: Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences and College of Stomatology, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Jinlin
authors.initials: J
authors.lastname: Song
authors.affiliation: Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences and College of Stomatology, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Ping
authors.identifier: 0000-0002-5017-8355
authors.initials: P
authors.lastname: Ji
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D020782:Matrix Metalloproteinases / Q000235:genetics*; D010518:Periodontitis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D020782:Matrix Metalloproteinases