title: In Vitro Activity of Tigecycline Against Orientia tsutsugamushi.
abstract: Scrub typhus is a zoonosis caused by Orientia tsutsugamushi (O. tsutsugamushi) occurring mainly in autumn in Korea. The need of new antibiotics has arisen with a report on strains resistant to antibiotics and chronic infection. This study aims to identify susceptibility of tigecycline in-vitro as a new therapeutic option for O. tsutsugamushi. Antibacterial activity of tigecycline against the O. tsutsugamushi was compared with doxycycline using flow cytometry assay. The inhibitory concentration 50 (IC₅₀) was 3.59×10⁻³ μg/mL in doxycycline-treated group. Whereas in 0.71×10⁻³ μg/mL tigecycline-treated group. These findings indicate that tigecycline may be a therapeutic option for the treatment of scrub typhus.
authors.affiliation: Translation Research Center, Inha University School of Medicine, Incheon, Korea.
authors.forename: Sun Myoung
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
authors.forename: Hae Yoon
authors.initials: HY
authors.lastname: Kwon
authors.affiliation: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
authors.forename: Jae Hyoung
authors.initials: JH
authors.lastname: Im
authors.affiliation: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
authors.forename: Ji Hyeon
authors.initials: JH
authors.lastname: Baek
authors.affiliation: Department of Social & Preventive Medicine, Inha University School of Medicine, Incheon, Korea.
authors.forename: Seung Sik
authors.initials: SS
authors.lastname: Hwang
authors.affiliation: Department of Microbiology, Inha University School of Medicine, Incheon, Korea.
authors.forename: Jae Seung
authors.initials: JS
authors.lastname: Kang
authors.affiliation: Department of Internal Medicine, Hanmaeum Hospital, Jeju, Korea.
authors.forename: Moon Hyun
authors.initials: MH
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea. ljinsoo@inha.ac.kr.
authors.forename: Jin Soo
authors.initials: JS
authors.lastname: Lee
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D012285:Orientia tsutsugamushi / Q000187:drug effects* / Q000502:physiology; D012612:Scrub Typhus / Q000188:drug therapy; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline
keywords: IC₅₀; Orientia tsutsugamushi; scrub typhus; tigecycline