title: [Efficacy and safety of long pulse 1064 nm Nd:YAG laser for treatment of onychomycosis of the toenails].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of long pulse 1064 nm Nd:YAG laser therapy in the treatment of onychomycosis of the toenails.
  
  
  METHODS
  A total of 104 patients with onychomycosis (461 toenails) were divided by age into ≥60 years group and <60 years group, and each group was further divided into subgroups according to Scoring Clinical Index of Onychomycosis (SCIO) scoring and the location of the compromised toenails. All the toenails were treated with 10 to12 sessions of long pulse 1064 nm Nd:YAG laser therapy at the interval of 1 week. All the patients were followed up for 48 weeks after the initial treatment to assess the clinical efficacy and adverse reactions.
  
  
  RESULTS
  The overall clinical response rate in these patients was 72.5% by the end of the 48-week follow-up. In patients aged <60 years, the clinical response rate and mycological cure rate were significantly higher than the rates in patients aged ≥60 years (P<0.05). No significant differences were observed in the response rates between different SCIO subgroups (P>0.05); the 2nd to 4th toenails showed better outcomes after the therapy than the 1st and 5th toenails (P<0.05). No adverse reactions related with the therapy were recorded in these patients.
  
  
  CONCLUSIONS
  Long pulse 1064 nm Nd:YAG laser is an effective and safe approach for treatment of onychomycosis of the toenails.
authors.affiliation: Department of Dermatology and Venerology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.E-mail: 460081758@qq.com.
authors.forename: Ye-Mei
authors.initials: YM
authors.lastname: Yang
authors.forename: Si-Tong
authors.initials: ST
authors.lastname: Zhou
authors.forename: Yong-Xuan
authors.initials: YX
authors.lastname: Hu
authors.forename: Zu-Hao
authors.initials: ZH
authors.lastname: Mao
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wu
authors.forename: Xue
authors.initials: X
authors.lastname: Han
authors.forename: Kang-Xing
authors.initials: KX
authors.lastname: Liu
authors.forename: Shi-Yun
authors.initials: SY
authors.lastname: Hunag
authors.forename: Yan-Qing
authors.initials: YQ
authors.lastname: Hu
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Xian-Yi
authors.initials: XY
authors.lastname: Zhou
mesh_terms: D006801:Humans; D053844:Lasers, Solid-State; D008875:Middle Aged; D009262:Nails / Q000382:microbiology*; D014009:Onychomycosis / Q000628:therapy*; D016896:Treatment Outcome