title: Synthesis and Antibacterial Activity of 3-(Substituted)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one.
abstract: A series of novel 3-(substituted)-2-(substituted quinazolinylamino)quinazolin-4(3H)-ones were synthesized by the reaction of 3-(substituted)-2-hydrazino-quinazoline-4(3H)-ones with 2-phenyl-3,1-benzoxazin-4-one. The starting materials 3-(substituted)-2-hydrazino-quinazolin-4(3H)-ones were synthesized from various primary amines by a multistep synthesis. All the title compounds were tested for their antibacterial activity using ciprofloxacin as reference standard. Compounds 3-(4-fluorophenyl)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one (9a) and 3-(4-chlorophenyl)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one (9h) emerged as the most active compounds of the series. These compounds have shown most potent antibacterial activity against the tested organisms of Proteus vulgaris and Bacillus subtilis having zone of inhibition values of 1.1 cm and 1.4 cm for compound 9a 1.2 cm and 1.0 cm for compound 9h, respectively.
authors.affiliation: Department of Pharmaceutical Chemistry and Phytochemistry, Nethaji Institute of Pharmaceutical Sciences, Somidi, Kazipet, Warangal, Telangana 506003, India.
authors.forename: Ramgopal
authors.initials: R
authors.lastname: Appani
authors.affiliation: Department of Pharmaceutical Chemistry and Phytochemistry, Nethaji Institute of Pharmaceutical Sciences, Somidi, Kazipet, Warangal, Telangana 506003, India.
authors.forename: Baburao
authors.initials: B
authors.lastname: Bhukya
authors.affiliation: Department of Pharmaceutical Chemistry, Chaitanya Institute of Pharmaceutical Sciences, Rampur, Warangal, Telangana 506151, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Gangarapu