title: Biogenesis of antibiotics-viewing its history and glimpses of the future.
abstract: This review aims at comparing some historical data with the current situation in the study of biogenesis of natural compounds, antibiotics in the first place. Biogenesis of tetracyclines and cycloheximide and related compounds serves as example. Examples of molecular biological and bioinformatics methods used in the study of antibiotic biogenesis are described both in terms of its historical aspects and the current knowledge.
authors.affiliation: Institute of Microbiology v.v.i, Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20, Prague 4, Czech Republic. spizek@biomed.cas.cz.
authors.forename: J
authors.initials: J
authors.lastname: Spížek
authors.affiliation: Institute of Microbiology v.v.i, Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20, Prague 4, Czech Republic.
authors.forename: K
authors.initials: K
authors.lastname: Sigler
authors.affiliation: Institute of Microbiology v.v.i, Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20, Prague 4, Czech Republic.
authors.forename: T
authors.initials: T
authors.lastname: Řezanka
authors.affiliation: Research Institute for Scientists Emeriti (RISE), Drew University, Madison, NJ, USA.
authors.forename: A
authors.initials: A
authors.lastname: Demain
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000378:metabolism; D019295:Computational Biology; D055808:Drug Discovery / Q000266:history; D049673:History, 20th Century; D049674:History, 21st Century; D053858:Metabolic Networks and Pathways / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents