title: Glomeruloid hemangioma and POEMS syndrome.
abstract: POEMS syndrome is a paraneoplastic manifestation associated with hematopoietic disorders such as multiple myeloma and Castleman disease. POEMS is an acronym for the main clinical features of the syndrome, namely, Polyneuropathy, Organomegaly, Endocrinopathy, M protein, and Skin abnormalities. Glomeruloid hemangiomas are considered to be a specific clinical marker of POEMS syndrome. However, while they are not pathognomonic, their presence should raise suspicion of this syndrome or alert clinicians to its possible future development, as these lesions can appear years before the onset of the syndrome. We report the cases of 2 women with plasma cell dyscrasias and sudden onset of lesions with a vascular appearance and histologic findings consistent with glomeruloid hemangioma. Recognition of this vascular tumor is important for the early diagnosis of POEMS syndrome.
authors.affiliation: Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España. Electronic address: ignaciohdezaragues@gmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Hernández Aragüés
authors.affiliation: Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: A
authors.initials: A
authors.lastname: Pulido Pérez
authors.affiliation: Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: C
authors.initials: C
authors.lastname: Ciudad Blanco
authors.affiliation: Servicio de Anatomía Patológica, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: V
authors.initials: V
authors.lastname: Parra Blanco
authors.affiliation: Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: R
authors.initials: R
authors.lastname: Suárez Fernández
mesh_terms: D000369:Aged, 80 and over; D046169:Dermoscopy; D005260:Female; D006391:Hemangioma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis; D016878:POEMS Syndrome / Q000209:etiology* / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000473:pathology; D010954:Plasmacytoma / Q000150:complications* / Q000000981:diagnostic imaging; D000072078:Positron Emission Tomography Computed Tomography; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology
keywords: Glomeruloid hemangioma; Hemangioma glomeruloide; Paraneoplastic syndrome; Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin abnormalities syndrome; Síndrome de Polineuropatía, Organomegalia, Endocrinopatía, M proteína, Skin abnormalities; Síndrome paraneoplásico