title: Biodegradable Magnesium (Mg) Implantation Does Not Impose Related Metabolic Disorders in Rats with Chronic Renal Failure.
abstract: Mg and its alloys have been considered as one of the most promising biodegradable medical devices, but it was still unclear whether hypermagnesemia involved health risks would occur in persons with kidney disease due to their deteriorated kidney function for Mg ions excretion from their body. In this study, we established a chronic renal failure (CRF) model in rats induced by adenine administration prior to Mg implantation, aiming to predict if CRF patients are suitable for the use of Mg implants. The results showed that Mg levels in serum, urine, feces and internal organs had no significant changes after Mg implantation for both normal and CRF rats. Biochemical indices detection and histopathological analysis in kidney, liver and heart tissue confirmed that Mg implants did not induce any extra damage in animals even with renal failure. Our study indicates that Mg based orthopaedic medical device may be considered for use in CRF patients without biosafety concerns.
authors.affiliation: Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, P.R. China.|Center for Translational Medicine Research and Development, Institute of Biomedical and Health Engineering, Chinese Academy of Sciences, Shenzhen 518055, P.R. China.
authors.forename: Jiali
authors.initials: J
authors.lastname: Wang
authors.affiliation: Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, P.R. China.
authors.forename: Jiankun
authors.initials: J
authors.lastname: Xu
authors.affiliation: Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, P.R. China.
authors.forename: Waiching
authors.initials: W
authors.lastname: Liu
authors.affiliation: Guangdong Innovation Team for Biodegradable Magnesium and Medical Implants, E-ande Dongguan 523660, P.R. China.
authors.forename: Yangde
authors.initials: Y
authors.lastname: Li
authors.affiliation: Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, P.R. China.|Center for Translational Medicine Research and Development, Institute of Biomedical and Health Engineering, Chinese Academy of Sciences, Shenzhen 518055, P.R. China.|Guangdong Innovation Team for Biodegradable Magnesium and Medical Implants, E-ande Dongguan 523660, P.R. China.
authors.forename: Ling
authors.initials: L
authors.lastname: Qin
mesh_terms: D020341:Absorbable Implants; D000225:Adenine / Q000009:adverse effects*; D000818:Animals; D004195:Disease Models, Animal; D007668:Kidney / Q000737:chemistry; D007676:Kidney Failure, Chronic / Q000097:blood / Q000139:chemically induced / Q000473:pathology* / Q000652:urine*; D008099:Liver / Q000737:chemistry; D008274:Magnesium / Q000008:administration & dosage* / Q000097:blood / Q000652:urine; D008297:Male; D009206:Myocardium / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008274:Magnesium; D000225:Adenine