title: Long-term immunogenicity and safety of an inactivated hepatitis A vaccine in haemophilic patients.
abstract: As a consequence of recent outbreaks of HAV infection by blood products, 91 patients, haemophiliacs and subjects with bleeding disorders (10 of whom were also anti-HIV positive) susceptible to HAV infection received a formalin-inactivated hepatitis A vaccine (HAVRIX 720 Elisa Units, SmithKline Beecham). Subcutaneous injections were given in the deltoid region at 0, 1 and 6 months. The seroconversion rates and litres, expressed in GMT IU/1, were determined at 1, 2, 6, 7, 12, 18 and 24 months. No adverse reactions to the vaccine were observed. The highest percentage of responders observed was 98.7% in anti-HIV negative and 71.4% in anti-HIV positive patients. The anti-HAV GMT titres were higher in anti-HIV negative than in anti-HIV positive patients. The inactivated hepatitis A vaccine is safe, clinically well tolerated, and provides long-term protection against HAV infection.
authors.affiliation: Department of Internal Medicine and Infectious Diseases, Coagulation ServiceHaemophilia Center, University of Bari, ItalyHaemostasis and Thrombosis Laboratory, University of Bari, Italy Pietro Dentico, M.D., Professor of Tropical Diseases, University of Bari, Clinica Malattie Infettive Policlinico, 70124 Bari, Italy.*Nicola Ciavarella, M.D., Director, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Francesco A. Scaraggi, M.D., Specialist in Haematology, Haemostasis and Thrombosis Laboratory, Universiti Hospital Policlinico, Bari, Italy.Mario Schiavoni, M.D., Consultant, Blood Coagulation Service and Haemaphilia Centre, University Hospital Policlinico, Bari, Italy.Anna Volpe, B.Sc., Laboratory Technician, Internal Medicine, Bari, Italy.Antonio Fasano, M.D., Researcher, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Antonia Perricci, M.D., Specialist in Internal Medicine and Researcher in Haematology, University of Bari, Italy.Rosalba Buongiorno, M.D., Specialist in Infectious Diseases, University Hospital Policlinico, Bari, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Dentico
authors.affiliation: Department of Internal Medicine and Infectious Diseases, Coagulation ServiceHaemophilia Center, University of Bari, ItalyHaemostasis and Thrombosis Laboratory, University of Bari, Italy Pietro Dentico, M.D., Professor of Tropical Diseases, University of Bari, Clinica Malattie Infettive Policlinico, 70124 Bari, Italy.*Nicola Ciavarella, M.D., Director, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Francesco A. Scaraggi, M.D., Specialist in Haematology, Haemostasis and Thrombosis Laboratory, Universiti Hospital Policlinico, Bari, Italy.Mario Schiavoni, M.D., Consultant, Blood Coagulation Service and Haemaphilia Centre, University Hospital Policlinico, Bari, Italy.Anna Volpe, B.Sc., Laboratory Technician, Internal Medicine, Bari, Italy.Antonio Fasano, M.D., Researcher, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Antonia Perricci, M.D., Specialist in Internal Medicine and Researcher in Haematology, University of Bari, Italy.Rosalba Buongiorno, M.D., Specialist in Infectious Diseases, University Hospital Policlinico, Bari, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Ciavarella
authors.affiliation: Department of Internal Medicine and Infectious Diseases, Coagulation ServiceHaemophilia Center, University of Bari, ItalyHaemostasis and Thrombosis Laboratory, University of Bari, Italy Pietro Dentico, M.D., Professor of Tropical Diseases, University of Bari, Clinica Malattie Infettive Policlinico, 70124 Bari, Italy.*Nicola Ciavarella, M.D., Director, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Francesco A. Scaraggi, M.D., Specialist in Haematology, Haemostasis and Thrombosis Laboratory, Universiti Hospital Policlinico, Bari, Italy.Mario Schiavoni, M.D., Consultant, Blood Coagulation Service and Haemaphilia Centre, University Hospital Policlinico, Bari, Italy.Anna Volpe, B.Sc., Laboratory Technician, Internal Medicine, Bari, Italy.Antonio Fasano, M.D., Researcher, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Antonia Perricci, M.D., Specialist in Internal Medicine and Researcher in Haematology, University of Bari, Italy.Rosalba Buongiorno, M.D., Specialist in Infectious Diseases, University Hospital Policlinico, Bari, Italy.
authors.forename: F A
authors.initials: FA
authors.lastname: Scaraggi
authors.affiliation: Department of Internal Medicine and Infectious Diseases, Coagulation ServiceHaemophilia Center, University of Bari, ItalyHaemostasis and Thrombosis Laboratory, University of Bari, Italy Pietro Dentico, M.D., Professor of Tropical Diseases, University of Bari, Clinica Malattie Infettive Policlinico, 70124 Bari, Italy.*Nicola Ciavarella, M.D., Director, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Francesco A. Scaraggi, M.D., Specialist in Haematology, Haemostasis and Thrombosis Laboratory, Universiti Hospital Policlinico, Bari, Italy.Mario Schiavoni, M.D., Consultant, Blood Coagulation Service and Haemaphilia Centre, University Hospital Policlinico, Bari, Italy.Anna Volpe, B.Sc., Laboratory Technician, Internal Medicine, Bari, Italy.Antonio Fasano, M.D., Researcher, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Antonia Perricci, M.D., Specialist in Internal Medicine and Researcher in Haematology, University of Bari, Italy.Rosalba Buongiorno, M.D., Specialist in Infectious Diseases, University Hospital Policlinico, Bari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Schiavoni
authors.affiliation: Department of Internal Medicine and Infectious Diseases, Coagulation ServiceHaemophilia Center, University of Bari, ItalyHaemostasis and Thrombosis Laboratory, University of Bari, Italy Pietro Dentico, M.D., Professor of Tropical Diseases, University of Bari, Clinica Malattie Infettive Policlinico, 70124 Bari, Italy.*Nicola Ciavarella, M.D., Director, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Francesco A. Scaraggi, M.D., Specialist in Haematology, Haemostasis and Thrombosis Laboratory, Universiti Hospital Policlinico, Bari, Italy.Mario Schiavoni, M.D., Consultant, Blood Coagulation Service and Haemaphilia Centre, University Hospital Policlinico, Bari, Italy.Anna Volpe, B.Sc., Laboratory Technician, Internal Medicine, Bari, Italy.Antonio Fasano, M.D., Researcher, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Antonia Perricci, M.D., Specialist in Internal Medicine and Researcher in Haematology, University of Bari, Italy.Rosalba Buongiorno, M.D., Specialist in Infectious Diseases, University Hospital Policlinico, Bari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Volpe
authors.affiliation: Department of Internal Medicine and Infectious Diseases, Coagulation ServiceHaemophilia Center, University of Bari, ItalyHaemostasis and Thrombosis Laboratory, University of Bari, Italy Pietro Dentico, M.D., Professor of Tropical Diseases, University of Bari, Clinica Malattie Infettive Policlinico, 70124 Bari, Italy.*Nicola Ciavarella, M.D., Director, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Francesco A. Scaraggi, M.D., Specialist in Haematology, Haemostasis and Thrombosis Laboratory, Universiti Hospital Policlinico, Bari, Italy.Mario Schiavoni, M.D., Consultant, Blood Coagulation Service and Haemaphilia Centre, University Hospital Policlinico, Bari, Italy.Anna Volpe, B.Sc., Laboratory Technician, Internal Medicine, Bari, Italy.Antonio Fasano, M.D., Researcher, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Antonia Perricci, M.D., Specialist in Internal Medicine and Researcher in Haematology, University of Bari, Italy.Rosalba Buongiorno, M.D., Specialist in Infectious Diseases, University Hospital Policlinico, Bari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Fasano
authors.affiliation: Department of Internal Medicine and Infectious Diseases, Coagulation ServiceHaemophilia Center, University of Bari, ItalyHaemostasis and Thrombosis Laboratory, University of Bari, Italy Pietro Dentico, M.D., Professor of Tropical Diseases, University of Bari, Clinica Malattie Infettive Policlinico, 70124 Bari, Italy.*Nicola Ciavarella, M.D., Director, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Francesco A. Scaraggi, M.D., Specialist in Haematology, Haemostasis and Thrombosis Laboratory, Universiti Hospital Policlinico, Bari, Italy.Mario Schiavoni, M.D., Consultant, Blood Coagulation Service and Haemaphilia Centre, University Hospital Policlinico, Bari, Italy.Anna Volpe, B.Sc., Laboratory Technician, Internal Medicine, Bari, Italy.Antonio Fasano, M.D., Researcher, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Antonia Perricci, M.D., Specialist in Internal Medicine and Researcher in Haematology, University of Bari, Italy.Rosalba Buongiorno, M.D., Specialist in Infectious Diseases, University Hospital Policlinico, Bari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Perricci
authors.affiliation: Department of Internal Medicine and Infectious Diseases, Coagulation ServiceHaemophilia Center, University of Bari, ItalyHaemostasis and Thrombosis Laboratory, University of Bari, Italy Pietro Dentico, M.D., Professor of Tropical Diseases, University of Bari, Clinica Malattie Infettive Policlinico, 70124 Bari, Italy.*Nicola Ciavarella, M.D., Director, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Francesco A. Scaraggi, M.D., Specialist in Haematology, Haemostasis and Thrombosis Laboratory, Universiti Hospital Policlinico, Bari, Italy.Mario Schiavoni, M.D., Consultant, Blood Coagulation Service and Haemaphilia Centre, University Hospital Policlinico, Bari, Italy.Anna Volpe, B.Sc., Laboratory Technician, Internal Medicine, Bari, Italy.Antonio Fasano, M.D., Researcher, Blood Coagulation Service and Haemophilia Centre, University Hospital Policlinico, Bari, Italy.Antonia Perricci, M.D., Specialist in Internal Medicine and Researcher in Haematology, University of Bari, Italy.Rosalba Buongiorno, M.D., Specialist in Infectious Diseases, University Hospital Policlinico, Bari, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Buongiorno
keywords: HAV; HAV vaccine; HIV; haemophiliacs; inactivated vaccine; vaccine