title: A Cu-catalyzed four-component cascade reaction to construct β-ester-γ-amino ketones.
abstract: Herein, a novel Cu-catalyzed four-component cascade reaction, which encompasses styrenes, diazo compounds, amines, and tert-butyl hydroperoxide (TBHP), was developed for the synthesis of β-ester-γ-amino ketones. Mechanistically, this transformation was initiated by the interception of an electrophilic Cu-based carbene with nucleophilic α-aminoalkyl radicals, followed by a radical cascade process and an ionic Kornblum-DeLaMare reaction. The methodology was also distinguished by its wide substrate scope, easily available starting materials, and operational simplicity.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Renai Road, 215123 Suzhou, China. wanxb@suda.edu.cn.
authors.forename: Jiayue
authors.initials: J
authors.lastname: Ling
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yudong
authors.initials: Y
authors.lastname: Xu
authors.forename: Hanghang
authors.initials: H
authors.lastname: Wang
authors.forename: Yuanzheng
authors.initials: Y
authors.lastname: Lv
authors.forename: Meishan
authors.initials: M
authors.lastname: Ji
authors.forename: Liang
authors.initials: L
authors.lastname: Ma
authors.forename: Meihua
authors.initials: M
authors.lastname: Ma
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Wan