title: The progress of early growth response factor 1 and leukemia.
abstract: Early growth response gene-1 (EGR1) widely exists in the cell nucleus of such as, zebrafish, mice, chimpanzees and humans, an it also can be observed in the cytoplasm of some tumors. EGR1 was named just after its brief and rapid expression of different stimuli. Accumulating studies have extensively demonstrated that the widespread dysregulation of EGR1 is involved in hematological malignancies such as human acute myeloid leukemia (AML), chronic myelogenous leukemia, chronic lymphocytic leukemia, multiple myeloma, and B cell lymphoma. With the deep research on EGR1, its expression, function and regulatory mechanism has been gradually elucidated, and provides more possibilities for treatment strategies of patients with leukemia. Herein, we summarize the roles of EGR1 in its biological function and relationship with leukemia.
authors.affiliation: Key Laboratory for Modern Medicine and Technology of Shandong Province, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Ji'nan, Shandong, China; School of Medicine and Life Sciences, Ji'nan University, Ji'nan, Shandong, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Tian
authors.affiliation: Key Laboratory for Modern Medicine and Technology of Shandong Province, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Ji'nan, Shandong, China; School of Medicine and Life Sciences, Ji'nan University, Ji'nan, Shandong, China.
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Li
authors.affiliation: Key Laboratory for Modern Medicine and Technology of Shandong Province, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Ji'nan, Shandong, China; School of Medicine and Life Sciences, Ji'nan University, Ji'nan, Shandong, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Han
authors.affiliation: Graduate School of Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Graduate School of Bengbu Medical College, Bengbu, Anhui, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Song
authors.affiliation: Key Laboratory for Modern Medicine and Technology of Shandong Province, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Ji'nan, Shandong, China; School of Medicine and Life Sciences, Ji'nan University, Ji'nan, Shandong, China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Jiang
keywords: Early growth response gene-1 (EGR1); acute myeloid leukemia; tumor