title: Quality of life, functioning and cognition in bipolar disorder and major depression: A latent profile analysis.
abstract: This study aimed to identify profiles of functioning and quality of life (QOL) in depression (MDD), bipolar disorder (BD) and healthy adults, as well as the clinical, demographic and cognitive variables associated with each of these profiles. Participants completed the WHODAS 2.0 and WHOQOL-BREF, which were submitted to latent profile analysis. The four cluster solution provided the best fit for our data. Cluster 1 consisted mostly of healthy adults, and had the highest functioning and QOL. Clusters 2 contained older patients with subclinical depressive symptoms and psychiatric comorbidities, whose impairments in QOL and functioning were associated with mood symptoms and several cognitive abilities. Patients with MDD, BDI or BDII with mild to moderate depression, such as those in cluster 3, may benefit more significantly from interventions in cognitive flexibility, inhibition, planning, and sustained attention. Lastly, patients with mood disorders and clinically significant levels of depression, as well as a history of suicide attempts, like those in cluster 4, may benefit from interventions aimed at working memory, inhibitory control, and cognitive flexibility; that is, the three core executive functions. These findings should be further investigated, and used to guide treatments for patients with mood disorders and different patterns of functional impairment.
authors.affiliation: Department of Psychology, Pontifical Catholic University of Rio Grande do Sul, Brazil.
authors.forename: Charles
authors.initials: C
authors.lastname: Cotrena
authors.affiliation: Department of Psychology, Pontifical Catholic University of Rio Grande do Sul, Brazil. Electronic address: lauradbranco@gmail.com.
authors.forename: Laura Damiani
authors.initials: LD
authors.lastname: Branco
authors.affiliation: Department of Psychology, Pontifical Catholic University of Rio Grande do Sul, Brazil.
authors.forename: Renata
authors.initials: R
authors.lastname: Kochhann
authors.affiliation: Program for the Study and Research of Mood Disorders (PROPESTH), São Pedro Psychiatric Hospital, Brazil.
authors.forename: Flávio Milman
authors.initials: FM
authors.lastname: Shansis
authors.affiliation: Department of Psychology, Pontifical Catholic University of Rio Grande do Sul, Brazil. Electronic address: rochele.fonseca@gmail.com.
authors.forename: Rochele Paz
authors.initials: RP
authors.lastname: Fonseca
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001288:Attention / Q000502:physiology; D001714:Bipolar Disorder / Q000503:physiopathology / Q000523:psychology*; D016022:Case-Control Studies; D016000:Cluster Analysis; D003071:Cognition; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000503:physiopathology / Q000523:psychology*; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D013406:Suicide, Attempted / Q000523:psychology; D055815:Young Adult
keywords: Attention; Decision-making; Disability evaluation; Executive functions; Inhibition; Mood disorders; Quality of life