title: Micro and Nano Material Carriers for Immunomodulation.
abstract: Modulation of the immune system through the use of micro and nano carriers offers opportunities in transplant tolerance, autoimmunity, infectious disease, and cancer. In particular, polymeric, lipid, and inorganic materials have been used as carriers of proteins, nucleic acids, and small drug molecules to direct the immune system toward either suppressive or stimulatory states. Current technologies have focused on the use of particulates or scaffolds, the modulation of materials properties, and the delivery of biologics or small drug molecules to achieve a desired response. Discussed are relevant immunology concepts, the types of biomaterial carriers used for immunomodulation highlighting their benefits and drawbacks, the material properties influencing immune responses, and recent examples in the field of transplant tolerance.
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL.
authors.forename: E
authors.initials: E
authors.lastname: Bracho-Sanchez
authors.affiliation: Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL.
authors.forename: C Q
authors.initials: CQ
authors.lastname: Xia
authors.affiliation: Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL.
authors.forename: M J
authors.initials: MJ
authors.lastname: Clare-Salzler
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL.|Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL.
authors.forename: B G
authors.initials: BG
authors.lastname: Keselowsky
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D056747:Immunomodulation / Q000187:drug effects*; D014612:Vaccines / Q000008:administration & dosage*
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D014612:Vaccines
keywords: basic (laboratory) research/science; bioengineering; immune regulation; immunobiology; immunosuppression/immune modulation; vaccine