title: Obesity in association with Sleep Apnea Syndrome as predictor for coronary-vascular comorbidities.
abstract: OBJECTIVE
  Sleep apnea syndrome (SAS) is a common disorder with growing awareness. We sought to evaluate if the presence of obesity in patients with SAS is associated with a high risk for development of coronary-vascular comorbidities.
  
  
  METHODS
  We performed a retrospective study that included 1370 patients (30.3% female and 69.7% male) diagnosed with SAS from May 2005 to May 2012. The collected data included body mass index (BMI), waist/ hip ratio, abdominal, neck, hip circumference and Epworth Sleepiness Scale. The positive diagnostic of SAS was based on apnea-hypopnea index (AHI) provided by polysomnography, and patient comorbidities were obtained from the sleep laboratory records.
  
  
  RESULTS
  From the total of 1370 patients, 989 (72%) had grade I to III obesity, 305 (22%) were overweight and only 76 (6%) had a normal weight. Cardiovascular comorbidities were presented in 60.6% of patients, with coronary disease ranking first (34.2%) followed by heart failure (22.6%) and stroke (3.8%). The predictors for cardiovascular comorbidities were coronary disease (OR 2.1, 95% Cl 1.20-3.39, p = 0.0063), heart failure (OR 3.44, 95% Cl 1.60-7.74, p < 0.001) but not stroke (OR 2.3 95% Cl 0.57-13.84, p = 0.357). Analyzing the polysomnography parameters we found a strong correlation for AHI (p < 0.0001), oxygen desaturation index (p < 0.0001) and mean average oxyhaemoglobin saturation (p < 0.0001).
  
  
  CONCLUSIONS
  Overweight and obese patients with SAS have a poor outcome, being at high risk of developing other comorbidities like coronary disease and heart failure.
authors.forename: Roxana
authors.initials: R
authors.lastname: Pleavă
authors.forename: Dan
authors.initials: D
authors.lastname: Gaiţă
authors.forename: Carmen
authors.initials: C
authors.lastname: Ardeleanu
authors.forename: Stefan
authors.initials: S
authors.lastname: Frentz
authors.forename: Mihai
authors.initials: M
authors.lastname: Udrescu
authors.forename: Letiţia
authors.initials: L
authors.lastname: Udrescu
authors.forename: Rodica
authors.initials: R
authors.lastname: Dan
authors.forename: Daniela
authors.initials: D
authors.lastname: Reisz
authors.forename: Stefan
authors.initials: S
authors.lastname: Mihăicuţă
mesh_terms: D000328:Adult; D000886:Anthropometry; D015992:Body Mass Index; D003327:Coronary Disease / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D015994:Incidence; D008297:Male; D009765:Obesity / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D050177:Overweight / Q000150:complications; D017286:Polysomnography; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012383:Romania / Q000453:epidemiology; D064346:Sagittal Abdominal Diameter; D012680:Sensitivity and Specificity; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology; D020521:Stroke / Q000209:etiology; D055105:Waist Circumference; D049629:Waist-Hip Ratio