title: Ethylene glycol promoted catalyst-free pseudo three-component green synthesis of bis(coumarin)s and bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s.
abstract: An ethylene glycol promoted catalyst-free practically efficient and sustainable approach has been developed for the synthesis of several benzylidene-bis-(4-hydroxycoumarin)s and 4,[Formula: see text]-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s by the pseudo three-component reaction of an aldehyde with 4-hydroxycoumarin and 3-methyl-1-phenylpyrazol-5-one, respectively. Inexpensive, non-toxic, and easily available ethylene glycol used as the reaction solvent and promoter renders an efficient protocol in terms of catalyst-free reaction conditions, short reaction time, high yield, practical utility, and green approach.
authors.affiliation: Department of Chemistry, Deogiri College, Station Road, Aurangabad, MS, 431 005, India.
authors.forename: Sushama S
authors.initials: SS
authors.lastname: Kauthale
authors.affiliation: Department of Chemistry, Shri Muktanand College, Gangapur, MS, 431 109, India.
authors.forename: Sunil U
authors.initials: SU
authors.lastname: Tekale
authors.affiliation: Department of Chemistry, Deogiri College, Station Road, Aurangabad, MS, 431 005, India.
authors.forename: Kavita M
authors.initials: KM
authors.lastname: Jadhav
authors.affiliation: Department of Chemistry, Deogiri College, Station Road, Aurangabad, MS, 431 005, India. rppawar@yahoo.com.
authors.forename: Rajendra P
authors.initials: RP
authors.lastname: Pawar
mesh_terms: D002384:Catalysis; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D019855:Ethylene Glycol / Q000737:chemistry*; D055772:Green Chemistry Technology / Q000379:methods; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003374:Coumarins; D011720:Pyrazoles; C031280:pyrazole; D019855:Ethylene Glycol
keywords: Biscoumarins; Bispyrazoles; Catalyst-free; Green chemistry; MCRs