title: Personalised treatment for cognitive dysfunction in individuals with schizophrenia spectrum disorders.
abstract: Cognitive deficits are a well-recognised issue for individuals diagnosed with schizophrenia spectrum disorders. Despite positive group findings for the use of cognitive remediation (CR) interventions, there are substantial individual differences in response to treatment. In addition, the aggregate CR literature reports low moderate effect sizes for cognitive and functional outcomes. Based on personalised medicine theory, this paper uses extant CR literature to examine the individual characteristics determined to predict treatment response. These characteristics, which fall into the broad categories of cognitive, psychological, and biological can be used as tailoring variables to personalise CR to an individual's unique profile. Personalisation through the use of these tailoring variables has the potential to improve the delivery of CR to maximise treatment outcomes.
authors.affiliation: a Department of Psychiatry , Columbia University , New York , USA.
authors.forename: Alice
authors.initials: A
authors.lastname: Medalia
authors.affiliation: b Department of Psychology , Long Island University , Brooklyn , USA.
authors.forename: Alice M
authors.initials: AM
authors.lastname: Saperstein
authors.affiliation: a Department of Psychiatry , Columbia University , New York , USA.|b Department of Psychology , Long Island University , Brooklyn , USA.
authors.forename: Marie C
authors.initials: MC
authors.lastname: Hansen
authors.affiliation: a Department of Psychiatry , Columbia University , New York , USA.
authors.forename: Seonjoo
authors.initials: S
authors.lastname: Lee
mesh_terms: D001288:Attention; D015928:Cognitive Behavioral Therapy; D060825:Cognitive Dysfunction / Q000209:etiology / Q000628:therapy*; D006801:Humans; D009042:Motivation; D057285:Precision Medicine / Q000379:methods*; D012559:Schizophrenia / Q000150:complications* / Q000235:genetics; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
keywords: Cognitive remediation; neurocognition; personalised treatment; schizophrenia