title: Association between variants in nicotinic acetylcholine receptor genes and smoking cessation in a Chinese rural population.
abstract: Genetic studies have revealed a significant association between variants in nicotinic acetylcholine receptor (CHRN) genes and smoking cessation, but the results are inconsistent. In this study, we aimed to examine the relationship between single nucleotide polymorphisms (SNPs) in seven CHRN genes and smoking cessation in a Chinese rural population.
  
  
  
  Participants were recruited from 17 villages of 3 counties in Shandong, China. DNA was extracted from the blood samples. Thirty-two SNPs in seven CHRN genes were genotyped. Logistic regression was used to explore the relationship between single SNP and smoking cessation. Pearson's χ(2) test was performed to test the association between haplotype and smoking cessation.
  
  
  
  Rs578776 (in CHRNA3), rs660652 (in CHRNA3), and rs588765 (in CHRNA5) were significantly related to smoking cessation. Two haplotypes were associated with smoking cessation.
  
  
  
  This study confirmed the association between CHRN genes and smoking cessation in the Chinese rural population.
  
  
  
  Our findings provide confirmatory support to the role of CHRN genes to the etiology of smoking cessation in the Chinese rural population. (Am J Addict 2016;25:297-300).
authors.affiliation: Department of Epidemiology, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Suyun
authors.initials: S
authors.lastname: Li
authors.affiliation: Hebei Center for Disease Control and Prevention, Hebei, P. R. China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Pan
authors.affiliation: Department of Epidemiology, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Huijie
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Epidemiology, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Epidemiology, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Department of Epidemiology, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Mingkui
authors.initials: M
authors.lastname: Han
authors.affiliation: Department of Epidemiology, Shandong University, Jinan, Shandong, P. R. China.
authors.forename: Chongqi
authors.initials: C
authors.lastname: Jia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China; D003430:Cross-Sectional Studies; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011978:Receptors, Nicotinic / Q000235:genetics*; D012423:Rural Health; D012907:Smoking / Q000235:genetics*; D016540:Smoking Cessation; D055815:Young Adult
chemical_list: D005819:Genetic Markers; D011978:Receptors, Nicotinic