title: Effect of chronic intraperitoneal aminoguanidine on memory and expression of Bcl-2 family genes in diabetic rats.
abstract: Long-term hyperglycemia associates with memory defects via hippocampal cells damaging. The aim of the present study was to examine the effect of 1 month of i.p. injections of AG on passive avoidance learning (PAL) and hippocampal apoptosis in rat. Eighty male rats were divided into 10 groups: control, nondiabetics and STZ-induced diabetics treated with AG (50, 100, 200, and 400 mg/kg, i.p.). PAL and the Bcl-2 family gene expressions were determined. Diabetes resulted in memory and Bcl-2 family gene expression deficits. AG (50 and 100 mg/kg) significantly improved the learning and Bcl-2, Bcl-xl, Bax, and Bak impairment in diabetic rats. However, negative effects were indicated by higher doses of the drug (200 and 400 mg/kg). Present study suggests that 1 month of i.p. injections of lower doses of AG, may improve the impaired cognitive tasks in STZ-induced diabetic rats possibly by modulating Bcl-2 family gene expressions.
authors.affiliation: a Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Alipour
authors.affiliation: a Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Adineh
authors.affiliation: a Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Mosatafavi
authors.affiliation: a Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Azam
authors.initials: A
authors.lastname: Aminabadi
authors.affiliation: b Department of Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Hananeh
authors.initials: H
authors.lastname: Monirinasab
authors.affiliation: a Department of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Jafari
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation; D006146:Guanidines / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D006146:Guanidines; D019253:Proto-Oncogene Proteins c-bcl-2; C004479:pimagedine
keywords: Bcl-2 family genes; aminoguanidine; apprentissage d’évitement passif; diabetes mellitus; diabète sucré; famille des gènes Bcl-2; passive avoidance learning; rats