title: Pleiotropic effect of thyroid hormones on gene expression in fish as exemplified from the blue bream Ballerus ballerus (Cyprinidae): Results of transcriptomic analysis.
abstract: A pronounced pleiotropic effect of thyroid hormones on the regulation of gene expression in fish in postembryogenesis was demonstrated for the first time using larvae and juveniles of the blue bream Ballerus ballerus as an example. Genome-wide transcriptome sequencing (RNA-seq) identified 1212 differentially expressed genes in the brain and liver of fish kept in triiodothyronine solution (0.25 ng/mL). Our data show that the regulation of gene expression by thyroid hormones is widespread in nature: it involves not only the structural genes but also the regulatory genes. A significant number of genes under the control of thyroid hormones are involved in the determination of morphological traits.
authors.affiliation: National Research Center Kurchatov Institute, pl. Akademika Kurchatova 1, Moscow, 123182, Russia. rastorgueff@gmail.com.
authors.forename: S M
authors.initials: SM
authors.lastname: Rastorguev
authors.affiliation: National Research Center Kurchatov Institute, pl. Akademika Kurchatova 1, Moscow, 123182, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Nedoluzhko
authors.affiliation: Institute of Bioengineering, Federal Research Center "Fundamentals of Biotechnology,", Russian Academy of Sciences, Leninskii pr. 33-2, Moscow, 119071, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Levina
authors.affiliation: Institute of Bioengineering, Federal Research Center "Fundamentals of Biotechnology,", Russian Academy of Sciences, Leninskii pr. 33-2, Moscow, 119071, Russia.
authors.forename: E B
authors.initials: EB
authors.lastname: Prokhorchuk
authors.affiliation: National Research Center Kurchatov Institute, pl. Akademika Kurchatova 1, Moscow, 123182, Russia.|Institute of Bioengineering, Federal Research Center "Fundamentals of Biotechnology,", Russian Academy of Sciences, Leninskii pr. 33-2, Moscow, 119071, Russia.
authors.forename: K G
authors.initials: KG
authors.lastname: Skryabin
authors.affiliation: Institute of Bioengineering, Federal Research Center "Fundamentals of Biotechnology,", Russian Academy of Sciences, Leninskii pr. 33-2, Moscow, 119071, Russia.
authors.forename: B A
authors.initials: BA
authors.lastname: Levin
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism; D003530:Cyprinidae / Q000254:growth & development* / Q000378:metabolism*; D029941:Fish Proteins / Q000378:metabolism; D015870:Gene Expression / Q000502:physiology*; D020869:Gene Expression Profiling; D063990:Gene Ontology; D007814:Larva; D008099:Liver / Q000254:growth & development / Q000378:metabolism; D013963:Thyroid Hormones / Q000008:administration & dosage / Q000378:metabolism*; D059467:Transcriptome / Q000502:physiology; D014284:Triiodothyronine / Q000008:administration & dosage
chemical_list: D029941:Fish Proteins; D013963:Thyroid Hormones; D014284:Triiodothyronine