title: 8-Hydroxyquinolines in medicinal chemistry: A structural perspective.
abstract: 8-Hydroxyquinolines are heterocyclic compounds characterized by a moderate metal-binding affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades as they are privileged structures for the design of new drug candidates that exert a host of biological effects on various targets. The study of biological activities such as neuroprotection, anticancer, antibacterial, antifungal activity has been further promoted by the synthetic versatility of 8-hydroxyquinoline, which allows the generation of a large number of derivatives. These include numerous multifunctional analogues having the metal-binding motif of 8-hydroxyquinoline. In this review, we have summarized 8-hydroxyquinolines, 8-hydroxyquinoline-like compounds, 8-hydroxyquinoline-loaded nanoparticle systems with respect to their biological activities, interaction with metal ions and mechanisms of action.
authors.affiliation: Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria, 6, 95125 Catania, Italy; Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici, C.I.R.C.M.S.B., Unità di Ricerca di Catania, 95125 Catania, Italy. Electronic address: oliveri.valentina22@gmail.com.
authors.forename: Valentina
authors.initials: V
authors.lastname: Oliveri
authors.affiliation: Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria, 6, 95125 Catania, Italy; Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici, C.I.R.C.M.S.B., Unità di Ricerca di Catania, 95125 Catania, Italy.
authors.forename: Graziella
authors.initials: G
authors.lastname: Vecchio
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D056831:Coordination Complexes; D006912:Hydroxyquinolines / Q000737:chemistry / Q000494:pharmacology*; D008670:Metals; D013329:Structure-Activity Relationship
chemical_list: D056831:Coordination Complexes; D006912:Hydroxyquinolines; D008670:Metals
keywords: Alzheimer; Anticancer; Clioquinol; Glycoconjugate; Metal complexes; Nanoparticle; Nitroxoline; PBT2