title: Chemotherapy-related cognitive impairment in older patients with cancer.
abstract: Chemotherapy-related cognitive impairment (CRCI) can occur during or after chemotherapy and represents a concern for many patients with cancer. Among older patients with cancer, in whom there is little clinical trial evidence examining side effects like CRCI, many unanswered questions remain regarding risk for and resulting adverse outcomes from CRCI. Given the rising incidence of cancer with age, CRCI is of particular concern for older patients with cancer who receive treatment. Therefore, research related to CRCI in older patients with cancers is a high priority. In this manuscript, we discuss current gaps in research highlighting the lack of clinical studies of CRCI in older adults, the complex mechanisms of CRCI, and the challenges in measuring cognitive impairment in older patients with cancer. Although we focus on CRCI, we also discuss cognitive impairment related to cancer itself and other treatment modalities. We highlight several research priorities to improve the study of CRCI in older patients with cancer.
authors.affiliation: James P Wilmot Cancer Institute, University of Rochester, United States. Electronic address: kahpoh_loh@urmc.rochester.edu.
authors.forename: Kah Poh
authors.initials: KP
authors.lastname: Loh
authors.affiliation: James P Wilmot Cancer Institute, University of Rochester, United States.
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Janelsins
authors.affiliation: James P Wilmot Cancer Institute, University of Rochester, United States.
authors.forename: Supriya G
authors.initials: SG
authors.lastname: Mohile
authors.affiliation: University of Texas Health Science Center at Houston, United States.
authors.forename: Holly M
authors.initials: HM
authors.lastname: Holmes
authors.affiliation: The Ottawa Hospital Cancer Centre, Canada.
authors.forename: Tina
authors.initials: T
authors.lastname: Hsu
authors.affiliation: Harvard Medical School, Beth Israel Deaconess Medical Center, United States; Hebrew Senior Life, United States.
authors.forename: Sharon K
authors.initials: SK
authors.lastname: Inouye
authors.affiliation: University of Texas MD Anderson Cancer Center, United States.
authors.forename: Meghan S
authors.initials: MS
authors.lastname: Karuturi
authors.affiliation: Duke University Medical Center, United States.
authors.forename: Gretchen G
authors.initials: GG
authors.lastname: Kimmick
authors.affiliation: Memorial Sloan Kettering Cancer Center, United States.
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Lichtman
authors.affiliation: James P Wilmot Cancer Institute, University of Rochester, United States.
authors.forename: Allison
authors.initials: A
authors.lastname: Magnuson
authors.forename: Mary I
authors.initials: MI
authors.lastname: Whitehead
authors.affiliation: Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, United States.
authors.forename: Melisa L
authors.initials: ML
authors.lastname: Wong
authors.affiliation: Memorial Sloan Kettering Cancer Center, United States.
authors.forename: Tim A
authors.initials: TA
authors.lastname: Ahles
mesh_terms: D000367:Age Factors; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003071:Cognition / Q000187:drug effects*; D060825:Cognitive Dysfunction / Q000139:chemically induced* / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D000073216:Mental Status and Dementia Tests; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy*; D015995:Prevalence; D016032:Randomized Controlled Trials as Topic; D012106:Research / Q000592:standards*
chemical_list: D000970:Antineoplastic Agents
keywords: Cancer treatment; Chemotherapy; Cognitive impairment; Older patients; Research gaps