title: Long-term outcomes of simultaneous guided bone regeneration using native and cross-linked collagen membranes after 8 years.
abstract: OBJECTIVE
  To assess the clinical outcomes of simultaneous guided bone regeneration using native (CM) and cross-linked (VN) collagen membranes at 8 years.
  
  
  METHODS
  A total of n = 19 patients (19 implants) were available for the analysis. Each subject had received a simultaneous grafting of dehiscence-type defects using a natural bone mineral (NBM) and a random allocation to either CM and VN membranes (submerged healing of 4 months). Clinical parameters (e.g., bleeding on probing - BOP, probing pocket depth - PD, mucosal recession - MR, clinical attachment level - CAL) were recorded at 8 years after prosthesis installation.
  
  
  RESULTS
  At 8 years, CM and VN groups revealed comparable median BOP, PD, MR and CAL values at both vestibular and oral aspects. From 4 to 8 years (n = 14 patients), median CAL at the vestibular aspect improved in both groups; however, these changes were significantly higher at CM-treated sites (CM: 0.7 mm vs. VN: 0.5 mm).
  
  
  CONCLUSIONS
  The clinical long-term outcomes at 8 years were comparable in both VN and CM groups.
authors.affiliation: Department of Oral Surgery, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Schwarz
authors.affiliation: Department of Oral Surgery, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Schmucker
authors.affiliation: Department of Oral Surgery, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Becker
mesh_terms: D000328:Adult; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology*; D015921:Dental Implants; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010512:Periodontal Index; D013529:Surgical Wound Dehiscence / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; D015921:Dental Implants; D008567:Membranes, Artificial; D003094:Collagen
keywords: Bone regeneration; Bone substitutes; Clinical assessment; Clinical research; Clinical trials; Diagnosis; Guided tissue regeneration