title: Trends in ectopic pregnancy, hydatidiform mole and miscarriage in the largest obstetrics and gynaecology hospital in China from 2003 to 2013.
abstract: BACKGROUND
  Ectopic pregnancies, miscarriages and hydatidiform moles are the major types of pathological pregnancies in the early gestations of pregnancy and constitute an important public health problem. The trends and incidences of these pathological pregnancies may vary by ethnicity and geographical regions. This has not been fully investigated in the Chinese population. In this study we retrospectively report the trends of pathological pregnancies in Chinese population.
  
  
  METHODS
  Data on 22,511 women with ectopic pregnancy, hydatidiform mole and miscarriage were collected from the largest obstetrics and gynaecology hospital in China from 2003 to 2013. Data included age at diagnosis and the annual number of women with diagnosed ectopic pregnancy, hydatidiform mole and miscarriage.
  
  
  RESULTS
  The total number of ectopic pregnancy, hydatidiform mole and miscarriage was increased 3.5folds in 2013 compared to 2003. Ectopic pregnancy is the leading pathological pregnancy and miscarriage is increasing at a greater rate among the pathological pregnancies. The median age of women with hydatidiform mole at diagnosis significantly increased from 25.5 years to 29 years (p = 0.002), however the median age for other pathological pregnancies was not different between 2003 and 2013. The number of women with hydatidiform mole at diagnosis who were over 40 years old has increased. The mean maternal age is increased from 28.1 years old in 2003 to 29.4 years old in 2013 in this hospital.
  
  
  CONCLUSIONS
  We speculate that the increased maternal age may contribute to the increase in these pathological pregnancies between 2003 and 2013 in China.
authors.affiliation: Department of Gynaecology, The Hospital of Obstetrics & Gynaecology, Fudan University, 419 Fangxie Road, Shanghai, China.|Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 419 Fangxie Road, Shanghai, China.
authors.forename: Xue-Lian
authors.initials: XL
authors.lastname: Li
authors.affiliation: Department of Gynaecology, The Hospital of Obstetrics & Gynaecology, Fudan University, 419 Fangxie Road, Shanghai, China.|Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 419 Fangxie Road, Shanghai, China.
authors.forename: Dan-Feng
authors.initials: DF
authors.lastname: Du
authors.affiliation: Department of Gynaecology, The Hospital of Obstetrics & Gynaecology, Fudan University, 419 Fangxie Road, Shanghai, China.|Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 419 Fangxie Road, Shanghai, China.
authors.forename: Shang-Jie
authors.initials: SJ
authors.lastname: Chen
authors.affiliation: Department of Gynaecology, The Hospital of Obstetrics & Gynaecology, Fudan University, 419 Fangxie Road, Shanghai, China.|Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 419 Fangxie Road, Shanghai, China.
authors.forename: Sai-Hua
authors.initials: SH
authors.lastname: Zheng
authors.affiliation: Section of Epidemiology & Biostatistics, School of Population Health, The University of Auckland, Auckland, New Zealand.
authors.forename: Arier C
authors.initials: AC
authors.lastname: Lee
authors.affiliation: Department of Gynaecology, The Hospital of Obstetrics & Gynaecology, Fudan University, 419 Fangxie Road, Shanghai, China. q.chen@auckland.ac.nz.|Department of Obstetrics & Gynaecology, The University of Auckland, New Zealand. 85 Park Road, Grafton, Auckland, New Zealand. q.chen@auckland.ac.nz.
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000328:Adult; D000367:Age Factors; D002681:China / Q000453:epidemiology; D005260:Female; D006761:Hospitals; D006801:Humans; D006828:Hydatidiform Mole / Q000453:epidemiology*; D015994:Incidence; D008423:Maternal Age; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000453:epidemiology*; D012189:Retrospective Studies
keywords: China; Ectopic pregnancy; Hydatidiform mole; Maternal age; Miscarriage