title: Molecular Shape and the Hydrophobic Effect.
abstract: This review focuses on papers published since 2000 on the topic of the properties of solutes in water. More specifically, it evaluates the state of the art of our understanding of the complex relationship between the shape of a hydrophobe and the hydrophobic effect. To highlight this, we present a selection of references covering both empirical and molecular dynamics studies of small (molecular-scale) solutes. These include empirical studies of small molecules, synthetic hosts, crystalline monolayers, and proteins, as well as in silico investigations of entities such as idealized hard and soft spheres, small solutes, hydrophobic plates, artificial concavity, molecular hosts, carbon nanotubes and spheres, and proteins.
authors.affiliation: Department of Chemistry, Tulane University, New Orleans, Louisiana 70118; email: bgibb@tulane.edu.
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Hillyer
authors.affiliation: Department of Chemistry, Tulane University, New Orleans, Louisiana 70118; email: bgibb@tulane.edu.
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Gibb
mesh_terms: D000818:Animals; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D056004:Molecular Dynamics Simulation; D037742:Nanotubes, Carbon / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D013816:Thermodynamics; D014867:Water / Q000737:chemistry*
chemical_list: D037742:Nanotubes, Carbon; D011506:Proteins; D014867:Water
keywords: hydration; hydrophobic effect; noncovalent interactions; supramolecular chemistry; water