title: Enzyme-responsive polymer hydrogels for therapeutic delivery.
abstract: Enzymes play a central role in a spectrum of fundamental physiological processes and their altered expression level has been associated with many diseases and pathological disorders. Enzymes therefore can be exploited as a pristine biological trigger to tune material responses and to achieve controlled release of biomolecules at desired sites. This mini-review highlights enzyme-responsive polymer hydrogels for therapeutic delivery applications developed within the last five years, focusing on protease- and glycosidase-based catalyzed reactions. Strategies employed to produce responsive materials are described. Successful applications for controlled drug delivery are highlighted, and finally, future opportunities and challenges are presented.
authors.affiliation: School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW 2006, Australia rona.chandrawati@sydney.edu.au.
authors.forename: Rona
authors.initials: R
authors.lastname: Chandrawati
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D016503:Drug Delivery Systems / Q000379:methods*; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism*; D006026:Glycoside Hydrolases / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage* / Q000737:chemistry*; D010447:Peptide Hydrolases / Q000737:chemistry / Q000378:metabolism; D011108:Polymers
chemical_list: D001672:Biocompatible Materials; D004798:Enzymes; D020100:Hydrogels; D011108:Polymers; D006026:Glycoside Hydrolases; D010447:Peptide Hydrolases
keywords: Biomaterials; drug delivery; enzyme-responsive; glycosidase; hydrogels; protease