title: Dynamic finite-element model for efficient modelling of electric currents in electroporated tissue.
abstract: In silico experiments (numerical simulations) are a valuable tool for non-invasive research of the influences of tissue properties, electrode placement and electric pulse delivery scenarios in the process of electroporation. The work described in this article was aimed at introducing time dependent effects into a finite element model developed specifically for electroporation. Reference measurements were made ex vivo on beef liver samples and experimental data were used both as an initial condition for simulation (applied pulse voltage) and as a reference value for numerical model calibration (measured pulse current). The developed numerical model is able to predict the time evolution of an electric pulse current within a 5% error over a broad range of applied pulse voltages, pulse durations and pulse repetition frequencies. Given the good agreement of the current flowing between the electrodes, we are confident that the results of our numerical model can be used both for detailed in silico research of electroporation mechanisms (giving researchers insight into time domain effects) and better treatment planning algorithms, which predict the outcome of treatment based on both spatial and temporal distributions of applied electric pulses.
authors.affiliation: C3M d.o.o., Technology park 21, SI-1000 Ljubljana, Slovenia.
authors.forename: J
authors.initials: J
authors.lastname: Langus
authors.affiliation: University of Ljubljana, Faculty of Electrical Engineering, Laboratory of Biocybernetics, Tržaška 25, 1000 Ljubljana, Slovenia.
authors.forename: M
authors.initials: M
authors.lastname: Kranjc
authors.affiliation: University of Ljubljana, Faculty of Electrical Engineering, Laboratory of Biocybernetics, Tržaška 25, 1000 Ljubljana, Slovenia.
authors.forename: B
authors.initials: B
authors.lastname: Kos
authors.affiliation: C3M d.o.o., Technology park 21, SI-1000 Ljubljana, Slovenia.
authors.forename: T
authors.initials: T
authors.lastname: Šuštar
authors.affiliation: University of Ljubljana, Faculty of Electrical Engineering, Laboratory of Biocybernetics, Tržaška 25, 1000 Ljubljana, Slovenia.
authors.forename: D
authors.initials: D
authors.lastname: Miklavčič
mesh_terms: D000818:Animals; D002417:Cattle; D003198:Computer Simulation; D004553:Electric Conductivity; D053672:Electrochemotherapy; D018274:Electroporation / Q000379:methods*; D020342:Finite Element Analysis; D008099:Liver / Q000502:physiology*; D008954:Models, Biological