title: A Novel Approach to the Nutrigenetics and Nutrigenomics of Obesity and Weight Management.
abstract: Nutrigenetics and nutrigenomics, as well as diet and exercise, play an important role in the development and treatment of obesity and its comorbidities. If an individual's susceptibility to becoming obese and their responsiveness to weight loss interventions are to be understood, then it needs to be addressed at a molecular and metabolic level, including genetic interaction. This review proposes a three-pillar approach to more fully comprehend the complexity of diet-gene interactions in obesity. Peroxisomal proliferating-activated receptor gamma (PPARG) and mitochondrial uncoupling protein-1 (UCP-1) are explored in detail. Illustrating how an understanding of nutritional biochemistry, nutrigenomics, and nutrigenetics may be the key to understanding differences observed in the obese phenotype that vary both within and across populations.
authors.affiliation: Manuka Science, 17 Roeland Square, Drury Lane, Cape Town, South Africa. yael@manukascience.co.za.|Department of Nutritional Sciences, School of Health Related Professions, Rutgers School of Dental Medicine, Newark, NJ, USA. yael@manukascience.co.za.
authors.forename: Yael T
authors.initials: YT
authors.lastname: Joffe
authors.affiliation: School of Human Movement Studies, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Christine A
authors.initials: CA
authors.lastname: Houghton
mesh_terms: D001835:Body Weight / Q000235:genetics*; D004032:Diet; D006801:Humans; D054647:Nutrigenomics / Q000379:methods*; D009747:Nutritional Physiological Phenomena; D009765:Obesity / Q000235:genetics* / Q000517:prevention & control*
keywords: Nutrigenetics; Nutrigenomics; Nutritional biochemistry; Obesity; PPARG; UCP-1; Weight loss