title: Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women.
abstract: Emerging evidence suggests positive associations between serum anti-Müllerian hormone (AMH), a marker of ovarian function, and breast cancer risk. Body size at young ages may influence AMH levels, but few studies have examined this. Also, no studies have examined the relation of AMH levels with breast density, a strong predictor of breast cancer risk.
  
  
  
  We examined associations of early life body fatness, AMH concentrations, and breast density among 172 women in the Dietary Intervention Study in Children (DISC). Height and weight were measured at baseline (ages 8-10) and throughout adolescence. Serum AMH concentrations and breast density were assessed at ages 25-29 at the DISC 2006 Follow-up visit. We used linear mixed effects models to quantify associations of AMH (dependent variable) with quartiles of age-specific youth body mass index (BMI) Z-scores (independent variable). We assessed cross-sectional associations of breast density (dependent variable) with AMH concentration (independent variable).
  
  
  
  Neither early life BMI nor current adult BMI was associated with AMH concentrations. There were no associations between AMH and percent or absolute dense breast volume. In contrast, women with higher AMH concentrations had significantly lower absolute nondense breast volume (Ptrend < 0.01).
  
  
  
  We found no evidence that current or early life BMI influences AMH concentrations in later life. Women with higher concentrations of AMH had similar percent and absolute dense breast volume, but lower nondense volume.
  
  
  
  These results suggest that AMH may be associated with lower absolute nondense breast volume; however, future prospective studies are needed to establish temporality. Cancer Epidemiol Biomarkers Prev; 25(7); 1151-7. ©2016 AACR.
authors.affiliation: Slone Epidemiology Center at Boston University, Boston, Massachusetts. kab15@bu.edu.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Bertrand
authors.affiliation: Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Baer
authors.affiliation: Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
authors.forename: E John
authors.initials: EJ
authors.lastname: Orav
authors.affiliation: Dangeard Group, Aix-en-Provence, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Klifa
authors.affiliation: Ansh Labs Inc., Webster, Texas.
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Radiology, University of California, San Francisco, California.
authors.forename: Nola M
authors.initials: NM
authors.lastname: Hylton
authors.affiliation: Kaiser Permanente Center for Health Research, Portland, Oregon.
authors.forename: Erin S
authors.initials: ES
authors.lastname: LeBlanc
authors.affiliation: College of Public Health, University of Iowa, Iowa City, Iowa.
authors.forename: Linda G
authors.initials: LG
authors.lastname: Snetselaar
authors.affiliation: Department of Preventive Medicine, Northwestern University, Chicago, Illinois.
authors.forename: Linda
authors.initials: L
authors.lastname: Van Horn
authors.affiliation: Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
authors.forename: Joanne F
authors.initials: JF
authors.lastname: Dorgan
mesh_terms: D000273:Adipose Tissue; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D015992:Body Mass Index; D000071060:Breast Density; D001943:Breast Neoplasms / Q000209:etiology; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D012307:Risk Factors; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D054304:Anti-Mullerian Hormone