title: In vitro and in vivo brain-targeting chemo-photothermal therapy using graphene oxide conjugated with transferrin for Gliomas.
abstract: Current therapies for treating malignant glioma exhibit low therapeutic efficiency because of strong systemic side effects and poor transport across the blood brain barrier (BBB). Herein, we combined targeted chemo-photothermal glioma therapy with a novel multifunctional drug delivery system to overcome these issues. Drug carrier transferrin-conjugated PEGylated nanoscale graphene oxide (TPG) was successfully synthesized and characterized. When loaded on the proposed TPG-based drug delivery (TPGD) system, the anticancer drug doxorubicin could pass through the BBB and improve drug accumulation both in vitro and in vivo. TPGD was found to perform dual functions in chemotherapy and photothermal therapy. Targeted TPGD combination therapy showed higher rates of glioma cell death and prolonged survival of glioma-bearing rats compared with single doxorubicin or PGD therapy. In conclusion, we developed a potential nanoscale drug delivery system for combined therapy of glioma that can effectively decrease side effects and improve therapeutic effects.
authors.affiliation: SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.
authors.forename: Haixin
authors.initials: H
authors.lastname: Dong
authors.affiliation: SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Jin
authors.affiliation: SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Liu
authors.affiliation: SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.
authors.forename: Honglian
authors.initials: H
authors.lastname: Xiong
authors.affiliation: SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Qiu
authors.affiliation: SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou, 510631, China. ann@scnu.edu.cn.
authors.forename: Zhouyi
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001692:Biological Transport; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000628:therapy*; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D005910:Glioma / Q000628:therapy*; D006108:Graphite / Q000737:chemistry; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D049329:Nanostructures / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D051381:Rats; D014168:Transferrin / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D014168:Transferrin; D011092:Polyethylene Glycols; D006108:Graphite; D004317:Doxorubicin
keywords: Blood brain barrier; Brain glioma; Brain-targeting drug delivery; Chemo-photothermal therapy; Drug penetration; Graphene oxide