title: Lycopene Improves Diet-Mediated Recuperation in Rat Model of Nonalcoholic Fatty Liver Disease.
abstract: The aim of the present study was to evaluate the synergic effect of lycopene (LYC) treatment with a dietary control in a nonalcoholic fatty liver disease (NAFLD) model induced with a high-fat diet (HFD). Sprague-Dawley rats were fed during 4 weeks with a normal diet (ND·4w) or an HFD (HFD·4w) to produce an NAFLD model. Then, rats from the ND·4w group continued during 4 weeks with the same diet (ND·8w), and rats from HFD were fed during 4 weeks with an ND (HFD·4w+ND·4w) or an ND plus LYC (HFD·4w+ND+LYC·4w). LYC (20 mg/kg) was administered daily by gavage. ND and ND+LYC diets partially reverted the following alterations due to HFD: liver weight, serum low-density lipoproteins (LDL), hepatic total cholesterol (TC), and catalytic activity of hepatic superoxide dismutase, catalase, and glutathione peroxidase, as well as macroscopic and microscopic images of livers. A higher recuperation to reach normality was obtained with ND+LYC in: liver weight, hepatic TC, serum LDL, and, in some instances, macroscopic and microscopic images of livers. Failures to recovery with both NDs were observed for malondialdehyde level and serum aspartate aminotransferase activity. Taken together, the results from this study suggest the potentially protective role of LYC against NAFLD; however, more clinical trials are needed to support this idea.
authors.affiliation: 1 School of Natural Sciences, Autonomous University of Queretaro , Queretaro, Mexico .
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Piña-Zentella
authors.affiliation: 1 School of Natural Sciences, Autonomous University of Queretaro , Queretaro, Mexico .
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Rosado
authors.affiliation: 2 Department of Histopathology, School of Medicine, Autonomous University of Queretaro , Queretaro, Mexico .
authors.forename: Marco A
authors.initials: MA
authors.lastname: Gallegos-Corona
authors.affiliation: 3 Research and Graduate Studies in the Department of Food Science, School of Chemistry, Autonomous University of Queretaro , Queretaro, Mexico .
authors.forename: Luis Alberto
authors.initials: LA
authors.lastname: Madrigal-Pérez
authors.affiliation: 1 School of Natural Sciences, Autonomous University of Queretaro , Queretaro, Mexico .
authors.forename: Olga P
authors.initials: OP
authors.lastname: García
authors.affiliation: 3 Research and Graduate Studies in the Department of Food Science, School of Chemistry, Autonomous University of Queretaro , Queretaro, Mexico .
authors.forename: Minerva
authors.initials: M
authors.lastname: Ramos-Gomez
mesh_terms: D000818:Animals; D002338:Carotenoids / Q000008:administration & dosage*; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D000077276:Lycopene; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease / Q000188:drug therapy* / Q000201:enzymology; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002338:Carotenoids; D008315:Malondialdehyde; D002784:Cholesterol; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000077276:Lycopene
keywords: carotenoid; hepatoprotection; oxidative stress