title: [Severe Japanese Spotted Fever Complicated by Acute Respiratory Failure in Kobe City].
abstract: We report herein on a case of severe Japanese spotted fever complicated by acute respiratory failure in Kobe City. A 70-year-old female presenting with general malaise and systematic erythema was admitted to our hospital in June, 2013. From her history and physical examination, she was found to be suffering from scleroderma and mild interstitial pneumonia. From admission, the patient was noted to have a fever of 39 degrees C accompanied by relative bradycardia. Physical examination revealed a black eschar on her right leg, making us suspect rickettsial infection since Kobe City is not an area predisposed to Japanese spotted fever. Three days after admission, her condition worsened and treatment with minocycline and levofloxacin was initiated in accordance with the treatment protocol for Japanese spotted fever. The following day, the patient developed acute respiratory distress syndrome (ARDS) and was put on a respirator. She gradually recovered with the antibiotic treatment and was discharged from the hospital 23 days after admission. The diagnosis of Japanese spotted fever was confirmed by conducting a polymerase chain reaction test on the eschar. Japanese spotted fever is noted to occur in any place other than Kobe City. Late diagnoses may result in aggravated cases of Japanese spotted fever, with the possibility of developing ARDS as a complication.
authors.forename: Junji
authors.initials: J
authors.lastname: Takiguchi
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Okimura
authors.forename: Mariko
authors.initials: M
authors.lastname: Ishii
authors.forename: Kayoko
authors.initials: K
authors.lastname: Okamura
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Shinya
authors.initials: S
authors.lastname: Inamoto
authors.forename: Shuji
authors.initials: S
authors.lastname: Ando
mesh_terms: D000208:Acute Disease; D000368:Aged; D005260:Female; D006801:Humans; D007564:Japan; D012131:Respiratory Insufficiency / Q000209:etiology*; D012282:Rickettsia Infections / Q000150:complications* / Q000453:epidemiology