title: Putative Physiopathological Explanation for the "Sock Sign" in Bone Scans.
abstract: Four patients were referred to our department to undergo a bone scan for suspected reflex sympathetic dystrophy in the upper limbs. After TC-HMDP injection in the foot, they developed a "sock sign," defined by highly increased uptake in the injected lower limb. The sock sign has been previously described in only 1 case in the literature and attributed to intra-arterial injection. Our images suggest that the sock sign might instead be the consequence of tracer extravasation at the injection site.
authors.affiliation: From the Nuclear Medicine Department, University Hospital of Bordeaux, Bordeaux, France.
authors.forename: Carole
authors.initials: C
authors.lastname: de Vaugelade
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Pinaquy
authors.forename: Philippe
authors.initials: P
authors.lastname: Fernandez
authors.forename: Laurence
authors.initials: L
authors.lastname: Bordenave
authors.forename: Elif
authors.initials: E
authors.lastname: Hindie
authors.forename: Paolo
authors.initials: P
authors.lastname: Zanotti-Fregonara
mesh_terms: D001842:Bone and Bones / Q000000981:diagnostic imaging*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000000981:diagnostic imaging*; D005528:Foot / Q000000981:diagnostic imaging*; D006801:Humans; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D035002:Lower Extremity; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012019:Reflex Sympathetic Dystrophy / Q000000981:diagnostic imaging*; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives
chemical_list: D019275:Radiopharmaceuticals; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013669:Technetium Tc 99m Medronate