title: SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer.
abstract: SOX7 as a tumor suppressor belongs to the SOX F gene subfamily and is associated with a variety of human cancers, including breast cancer, but the mechanisms involved are largely unclear. In the current study, we investigated the interactions between SOX7 and AXIN2 in their co-regulation on the Wnt/β-catenin signal pathway, using clinical specimens and microarray gene expression data from the GEO database, for their roles in breast cancer. We compared the expression levels of SOX7 and other co-expressed genes in the Wnt/β-catenin pathway and found that the expression of SOX7, SOX17 and SOX18 was all reduced significantly in the breast cancer tissues compared to normal controls. AXIN2 had the highest co-relativity with SOX7 in the Wnt/β-catenin signaling pathway. Clinicopathological analysis demonstrated that the down-regulated SOX7 was significantly correlated with advanced stages and poorly differentiated breast cancers. Consistent with bioinformatics predictions, SOX7 was correlated positively with AXIN2 and negatively with β-catenin, suggesting that SOX7 and AXIN2 might play important roles as co-regulators through the Wnt-β-catenin pathway in the breast tissue to affect the carcinogenesis process. Our results also showed Smad7 as the target of SOX7 and AXIN2 in controlling breast cancer progression through the Wnt/β-catenin signaling pathway.
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.|Collage of Pharmacy, Harbin Medical University, Harbin, 150081, China.|HMU-UCFM Centre for Infection and Genomics, Harbin, 150081, China.|Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, T2N 4N1, Canada.
authors.forename: Huidi
authors.initials: H
authors.lastname: Liu
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.
authors.forename: Emilio
authors.initials: E
authors.lastname: Mastriani
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.
authors.forename: Zi-Qiao
authors.initials: ZQ
authors.lastname: Yan
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.
authors.forename: Si-Yuan
authors.initials: SY
authors.lastname: Yin
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.
authors.forename: Qing-Hai
authors.initials: QH
authors.lastname: Li
authors.affiliation: Pathology Department, The First Hospital of Qiqihaer City, Qiqihaer, 161006, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Liu
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Bao
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Zhou
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.|Collage of Pharmacy, Harbin Medical University, Harbin, 150081, China.
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Kou
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.|Collage of Pharmacy, Harbin Medical University, Harbin, 150081, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Li
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.|Collage of Pharmacy, Harbin Medical University, Harbin, 150081, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.
authors.forename: Jianrui
authors.initials: J
authors.lastname: Liu
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.|Collage of Pharmacy, Harbin Medical University, Harbin, 150081, China.
authors.forename: Yongfang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.|Collage of Pharmacy, Harbin Medical University, Harbin, 150081, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yin
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.|Collage of Pharmacy, Harbin Medical University, Harbin, 150081, China.
authors.forename: Li
authors.initials: L
authors.lastname: Qiu
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.|Collage of Pharmacy, Harbin Medical University, Harbin, 150081, China.
authors.forename: Liling
authors.initials: L
authors.lastname: Gong
authors.affiliation: Genomics Research Centre, Harbin Medical University, Harbin, 150081, China.|HMU-UCFM Centre for Infection and Genomics, Harbin, 150081, China.|Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, T2N 4N1, Canada.
authors.forename: Shu-Lin
authors.initials: SL
authors.lastname: Liu
mesh_terms: D060466:Axin Protein / Q000378:metabolism*; D001943:Breast Neoplasms / Q000473:pathology*; D063646:Carcinogenesis; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D046228:Microarray Analysis; D055760:SOXF Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: C491761:AXIN2 protein, human; D060466:Axin Protein; C495270:CTNNB1 protein, human; C484456:SOX7 protein, human; D055760:SOXF Transcription Factors; D051153:Wnt Proteins; D051176:beta Catenin