title: A novel diarylheptanoid-bearing sesquiterpene moiety from the rhizomes of Alpinia officinarum.
abstract: A new diarylheptanoid analogue-bearing sesquiterpene moiety, named Alpinisin A, was isolated from the rhizomes of Alpinia officinarum Hance. The new structure was determined by various spectroscopic techniques (1)H-nuclear magnetic resonance ((1)H NMR), (13)C-attached proton test ((13)C-APT), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), (1)H-(1)H correlation spectroscopy ((1)H-(1)HCOSY), nuclear overhauser effect spectroscopy (NOESY) and high resolution electrospray ionization mass spectrometry (HR-ESI-MS). The compound was tested for cytotoxic activity in vitro against human tumour cell lines (gastric carcinoma cell -7901 (SGC-7901), Michigan Cancer Foundation-7 (MCF-7) and Caski), which showed significant inhibitory effects with IC50 levels of 11.42, 15.14 and 14.78 μM, respectively. The novel chemical structure characterised with a diarylheptanoid linked to a chain-like sesquiterpenoid should be highlighted.
authors.affiliation: a School of Pharmacy , Hainan Medical University , Haikou , P.R. China.
authors.forename: Na
authors.initials: N
authors.lastname: Wei
authors.affiliation: a School of Pharmacy , Hainan Medical University , Haikou , P.R. China.|b School of Public Health , Central South University , Changsha , P.R. China.
authors.forename: Zhonglin
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: c School of Pharmacy , Heilongjiang University of Chinese Medicine , Harbin , P.R. China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wei
authors.affiliation: a School of Pharmacy , Hainan Medical University , Haikou , P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a School of Pharmacy , Hainan Medical University , Haikou , P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
authors.affiliation: a School of Pharmacy , Hainan Medical University , Haikou , P.R. China.
authors.forename: Junqing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: b School of Public Health , Central South University , Changsha , P.R. China.
authors.forename: Lixiang
authors.initials: L
authors.lastname: Wu
authors.affiliation: a School of Pharmacy , Hainan Medical University , Haikou , P.R. China.
authors.forename: Shuiping
authors.initials: S
authors.lastname: Dai
authors.affiliation: a School of Pharmacy , Hainan Medical University , Haikou , P.R. China.
authors.forename: Youbin
authors.initials: Y
authors.lastname: Li
mesh_terms: D032429:Alpinia / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D036381:Diarylheptanoids / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000032:analysis; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D036381:Diarylheptanoids; D010936:Plant Extracts; D012717:Sesquiterpenes
keywords: Alpinia officinarum Hance; Alpinisin A; cytotoxicity activity