title: Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for colon cancer.
abstract: The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in a number of cancers. We investigated the colon cancer risk profile of D-Loop SNPs in a case-control study. The frequent alleles of nucleotides 73G/A, 146T/C, 195T/C, 324C/G, 16261C/T, and 16304T/C as well as the minor allele of 309C/C insert were significantly associated with an increased risk for colon cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for colon cancer risk evaluation.
authors.affiliation: a Department of Gastroenterology and Hepatology , The Fourth Hospital of Hebei Medical University , Shijiazhuang , PR China and.
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Guo
authors.affiliation: a Department of Gastroenterology and Hepatology , The Fourth Hospital of Hebei Medical University , Shijiazhuang , PR China and.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Zhao
authors.affiliation: a Department of Gastroenterology and Hepatology , The Fourth Hospital of Hebei Medical University , Shijiazhuang , PR China and.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Fan
authors.affiliation: b Department of General Surgery , The Fourth Hospital of Hebei Medical University , Shijiazhuang , PR China.
authors.forename: Yanming
authors.initials: Y
authors.lastname: Du
authors.affiliation: a Department of Gastroenterology and Hepatology , The Fourth Hospital of Hebei Medical University , Shijiazhuang , PR China and.
authors.forename: Yufei
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: b Department of General Surgery , The Fourth Hospital of Hebei Medical University , Shijiazhuang , PR China.
authors.forename: Guiying
authors.initials: G
authors.lastname: Wang
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000209:etiology / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D054629:Genome, Mitochondrial / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D004272:DNA, Mitochondrial
keywords: Colon cancer; D-Loop; SNPs; mtDNA