title: Bacterial Outer Membrane Vesicles as a Delivery System for Virulence Regulation.
abstract: Outer membrane vesicles (OMVs) are spherical nanostructures that are ubiquitously shed from gram-negative bacteria both in vitro and in vivo. Recent findings revealed that OMVs, which contain diverse components derived from the parent bacterium, play an important role in communication with neighboring bacteria and the environment. Furthermore, nanoscale proteoliposomes decorated with pathogen-associated molecules attract considerable attention as a non-replicative carrier for vaccines and drug materials. This review introduces recent advances in OMV biogenesis and discusses the roles of OMVs in the context of bacterial communication and virulence regulation. It also describes the remarkable accomplishments in OMV engineering for diverse therapeutic applications.
authors.affiliation: Department of Molecular Science and Technology, Department of Applied Chemistry and Biological Engineering, Ajou University, Suwon 16499, Republic of Korea.
authors.forename: Hyunjin
authors.initials: H
authors.lastname: Yoon
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry* / Q000627:therapeutic use; D021961:Cell Membrane Structures / Q000378:metabolism* / Q000648:ultrastructure; D006090:Gram-Negative Bacteria / Q000737:chemistry / Q000378:metabolism* / Q000472:pathogenicity; D056265:Microbial Interactions; D012475:Salmonella / Q000166:cytology / Q000502:physiology; D014774:Virulence; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D037521:Virulence Factors
keywords: Outer membrane vesicle; biogenesis; pathogen; virulence