title: Comparison between Early-Onset and Late-Onset Alzheimer's Disease Patients with Amnestic Presentation: CSF and (18)F-FDG PET Study.
abstract: OBJECTIVE
  To investigate the differences in brain glucose consumption between patients with early onset of Alzheimer's disease (EOAD, aged ≤65 years) and patients with late onset of Alzheimer's disease (LOAD, aged >65 years).
  
  
  METHODS
  Differences in brain glucose consumption between the groups have been evaluated by means of Statistical Parametric Mapping version 8, with the use of age, sex, Mini-Mental State Examination and cerebrospinal fluid values of AΒ1-42, phosphorylated Tau and total Tau as covariates in the comparison between EOAD and LOAD.
  
  
  RESULTS
  As compared to LOAD, EOAD patients showed a significant decrease in glucose consumption in a wide portion of the left parietal lobe (BA7, BA31 and BA40). No significant differences were obtained when subtracting the EOAD from the LOAD group.
  
  
  CONCLUSIONS
  The results of our study show that patients with EOAD show a different metabolic pattern as compared to those with LOAD that mainly involves the left parietal lobe.
authors.affiliation: Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Agostino
authors.initials: A
authors.lastname: Chiaravalloti
authors.affiliation: Department of Non-Invasive Brain Stimulation Unit, Department of Behavioural and Clinical Neurology, Rome, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Koch
authors.affiliation: Department of System Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Sofia
authors.initials: S
authors.lastname: Toniolo
authors.affiliation: Department of System Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Lorena
authors.initials: L
authors.lastname: Belli
authors.affiliation: Department of System Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Francesco Di
authors.initials: FD
authors.lastname: Lorenzo
authors.affiliation: Department of Non-Invasive Brain Stimulation Unit, Department of Behavioural and Clinical Neurology, Rome, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Gaudenzi
authors.affiliation: Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy; Department of IRCCS Neuromed, Pozzilli, Italy.
authors.forename: Orazio
authors.initials: O
authors.lastname: Schillaci
authors.affiliation: Department of Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Bozzali
authors.affiliation: Department of System Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sancesario
authors.affiliation: Department of System Medicine, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Martorana
keywords: Alzheimer's disease; Cerebrospinal fluid biomarkers; Early onset; Late onset; Precuneus