title: [Local Control of Advanced Breast Cancer with Mohs Paste and Systemic Therapy].
abstract: Unresectable locally advanced breast cancer results in a decline in patient quality of life because of the presence of bleeding, exudates, and strong odor. The clinical application of supportive care using Mohs paste for improving quality of life has become widespread. We report 2 cases of locally advanced breast cancer treated with systemic therapy and chemosurgery. Case 1 was a Japanese woman in her fifties who had a locally advanced left breast cancer. She had continuous bleeding and exudates, and received Mohs chemosurgery and endocrine therapy. One month later, the surface healed and dried up. The bleeding, exudates, and strong odor disappeared almost completely. Case 2 was a Japanese woman in her forties who had a locally advanced left breast cancer with massive exudates and oozing blood. She underwent Mohs chemosurgery 20 times, but the exudates and bleeding were not controlled. According to pathological findings, we confirmed her breast cancer to be of the triple negative subtype. After 2 courses of therapy with 5-fluorouracil, epirubicin, and cyclophosphamide, the tumor immediately decreased in diameter by 65%. The bleeding, exudates, and strong odor disappeared. Although Mohs chemosurgery is useful for local control of locally advanced breast cancer, this alone is insufficient to treat the disease. Early introduction of systemic therapy is considered essential in breast cancer treatment.
authors.affiliation: Dept. of Surgery, Saiseikai Yokohama-shi Tobu Hospital.
authors.forename: Shin
authors.initials: S
authors.lastname: Nishiya
authors.forename: Masakazu
authors.initials: M
authors.lastname: Doi
authors.forename: Akiko
authors.initials: A
authors.lastname: Oikawa
authors.forename: Asako
authors.initials: A
authors.lastname: Kawaura
authors.forename: Kouki
authors.initials: K
authors.lastname: Mihara
authors.forename: Shigeshi
authors.initials: S
authors.lastname: Ono
authors.forename: Kan
authors.initials: K
authors.lastname: Handa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Shintaro
authors.initials: S
authors.lastname: Shibutani
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Egawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nagashima
mesh_terms: D001943:Breast Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009824:Ointments / Q000008:administration & dosage; D011788:Quality of Life; D012883:Skin Ulcer / Q000188:drug therapy* / Q000209:etiology
chemical_list: D009824:Ointments