title: Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats.
abstract: This study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation. Rats were divided into 5 groups as (1) Healthy control, (2) Carrageenan control, (3) Carrageenan +Indomethacin 20mg/kg, orally, (4) Carrageenan +AC7954 (U-II receptor agonist, intraperitoneally) 30mg/kg and (5) Carrageenan +SB657510 (UTR antagonist, intraperitoneally) 30mg/kg. 1h after drug administration, carrageenan was injected. At the 3rd hour after carrageenan injection, agonist produced no effect while antagonist 63% anti-inflammatory effect respectively. UTR and UT-II expression increased in carrageenan induced paw tissue. Antagonist administration prevented the decrease in an antioxidant system and also capable to decrease TNF-α and IL-6 mRNA expressions. This study showed the role of urotensin II receptors in the physiopathogenesis of acute inflammatory response that underlying many diseases accompanied by inflammation.
authors.affiliation: Department of Pharmacology, Ataturk University Faculty of Medicine, 25240 Erzurum, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Cadirci
authors.affiliation: Department of Pharmacology, Ataturk University Faculty of Medicine, 25240 Erzurum, Turkey. Electronic address: hzekai@gmail.com.
authors.forename: Zekai
authors.initials: Z
authors.lastname: Halici
authors.affiliation: Department of Pharmacology, Kafkas University Faculty of Medicine, 36240 Kars, Turkey.
authors.forename: Muhammed
authors.initials: M
authors.lastname: Yayla
authors.affiliation: Department of Histology and Embryology, Ataturk University Faculty of Medicine, 25240 Erzurum, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Toktay
authors.affiliation: Department of Biochemistry, Ataturk University Faculty of Pharmacy, 25240 Erzurum, Turkey.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Bayir
authors.affiliation: Department of Pharmacology and Toxicology, Ataturk University Faculty of Veterinary Medicine, 25240 Erzurum, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Karakus
authors.affiliation: Department of Pharmacology, RTE University Faculty of Medicine, 53240 Rize, Turkey.
authors.forename: Atilla
authors.initials: A
authors.lastname: Topcu
authors.affiliation: Department of Histology and Embryology, 19 Mart University, Faculty of Medicine, 25240 Çanakkale, Turkey.
authors.forename: Basak
authors.initials: B
authors.lastname: Buyuk
authors.affiliation: Department of Pharmacology, Ataturk University Faculty of Medicine, 25240 Erzurum, Turkey.
authors.forename: Abdulmecit
authors.initials: A
authors.lastname: Albayrak
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D002351:Carrageenan / Q000633:toxicity; D002839:Chromans / Q000008:administration & dosage; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D015850:Interleukin-6 / Q000235:genetics; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D014579:Urotensins / Q000235:genetics / Q000378:metabolism*
chemical_list: C468786:3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one; D000893:Anti-Inflammatory Agents; D002839:Chromans; D015850:Interleukin-6; D043562:Receptors, G-Protein-Coupled; D014409:Tumor Necrosis Factor-alpha; D014579:Urotensins; C473142:Uts2r protein, rat; D002351:Carrageenan; C029677:urotensin II; D007213:Indomethacin
keywords: Inflammation; Rats; SB657510; TNF-Alpha; Urotensin II