title: Enhanced Lineage-Specific Differentiation Efficiency of Human Induced Pluripotent Stem Cells by Engineering Colony Dimensionality Using Electrospun Scaffolds.
abstract: Electrospun scaffolds with varied stiffness promote distinct colony morphology of human induced pluripotent stem cells, which affects their subsequent differentiation. On soft scaffolds, induced pluripotent stem cells develop 3D colonies due to the pliability of the electrospun fibrous networks, leading to greater differentiation tendency to ectodermal lineage.
authors.affiliation: Department of Bioengineering, University of California-Riverside, Materials Science & Engineering Building 331, 900 University Avenue, Riverside, CA, 92521, USA.
authors.forename: Maricela
authors.initials: M
authors.lastname: Maldonado
authors.affiliation: Department of Bioengineering, University of California-Riverside, Materials Science & Engineering Building 331, 900 University Avenue, Riverside, CA, 92521, USA.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Ico
authors.affiliation: Department of Bioengineering, University of California-Riverside, Materials Science & Engineering Building 331, 900 University Avenue, Riverside, CA, 92521, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Low
authors.affiliation: Department of Bioengineering, University of California-Riverside, Materials Science & Engineering Building 331, 900 University Avenue, Riverside, CA, 92521, USA.
authors.forename: Rebeccah J
authors.initials: RJ
authors.lastname: Luu
authors.affiliation: Department of Bioengineering, University of California-Riverside, Materials Science & Engineering Building 331, 900 University Avenue, Riverside, CA, 92521, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Nam
mesh_terms: D002454:Cell Differentiation; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism*; D054457:Tissue Scaffolds / Q000737:chemistry*
keywords: differentiation; electrospun scaffolds; induced pluripotent stem cells; mechanical stem cell niche