title: Bone metastasis: the importance of the neighbourhood.
abstract: During the past decade preclinical studies have defined many of the mechanisms used by tumours to hijack the skeleton and promote bone metastasis. This has led to the development and widespread clinical use of bone-targeted drugs to prevent skeletal-related events. This understanding has also identified a critical dependency between colonizing tumour cells and the cells of bone. This is particularly important when tumour cells first arrive in bone, adapt to their new microenvironment and enter a long-lived dormant state. In this Review, we discuss the role of different bone cell types in supporting disseminated tumour cell dormancy and reactivation, and highlight the new opportunities this provides for targeting the bone microenvironment to control dormancy and bone metastasis.
authors.affiliation: Division of Bone Biology, Garvan Institute of Medical Research, 384 Victoria Street, Sydney, New South Wales 2010, Australia.|St Vincent's Clinical School, University of New South Wales Medicine, Sydney, New South Wales 2052, Australia.|School of Biotechnology and Biomolecular Sciences, University of New South Wales Australia, Sydney, New South Wales 2052, Australia.
authors.forename: Peter I
authors.initials: PI
authors.lastname: Croucher
authors.affiliation: Division of Bone Biology, Garvan Institute of Medical Research, 384 Victoria Street, Sydney, New South Wales 2010, Australia.|St Vincent's Clinical School, University of New South Wales Medicine, Sydney, New South Wales 2052, Australia.
authors.forename: Michelle M
authors.initials: MM
authors.lastname: McDonald
authors.affiliation: St Vincent's Institute of Medical Research, 9 Princes Street, Fitzroy, Melbourne, Victoria 3065, Australia.|Department of Medicine, University of Melbourne, St Vincent's Hospital, Melbourne, Victoria 3065, Australia.
authors.forename: T John
authors.initials: TJ
authors.lastname: Martin
mesh_terms: D001859:Bone Neoplasms / Q000556:secondary* / Q000628:therapy; D016723:Bone Remodeling; D006801:Humans; D059016:Tumor Microenvironment