title: Do vaccinations affect the clinical course of systemic necrotising vasculitis? A prospective observational web-based study.
abstract: OBJECTIVE
  To estimate the impact of vaccinations, infections and traumatic life events on the disease activity of a web-based cohort of systemic necrotising vasculitis (SNV) patients.
  
  
  METHODS
  Adults diagnosed with SNV self-reported vaccinations, infectious episodes and traumatic life events every 3 months during follow-up on a secure dedicated website. Participants reported information on disease activity assessed with 3 scores: the French version of the Medical Outcome Study Short Form-36 (SF-36), the visual numerical scale for Patient Global Assessment (PGA) and the modified Disease Extent Index (mDEI).
  
  
  RESULTS
  Between December 2005 and October 2008, 145 participants (mean ± SD age 53±13 years; 57% males) were included. Mean follow-up was 445±325 days. SNVs were distributed as follows: 46% granulomatosis with polyangiitis (Wegener's), 22% eosinophilic granulomatosis with polyangiitis (Churg-Strauss), 18% polyarteritis nodosa and 8% microscopic polyangiitis. During follow-up, 94 vaccinations, 57 acute infectious episodes and 274 traumatic life events were reported. In univariate and multivariate analyses, only traumatic life events were significantly associated with decreased SF-36 mental and physical component scores. No significant SF-36, PGA and mDEI scores variations were reported during the 3 months following acute infectious episode or vaccine administration.
  
  
  CONCLUSIONS
  No significant clinical impact of vaccinations on SNV activity was found in this prospective observational study.
authors.affiliation: Univ. Paris-Descartes, Sorbonne Paris Cité, Médecine; Assistance Publique-Hôpitaux de Paris, Dept. of Infectious Diseases, Hôpital Cochin; Inserm CIC 1417; Sorbonne Univ., UPMC Univ. Paris 06, Inst.Pierre-Louis d'Épidémiologie-Santé Publ., Paris, France.
authors.forename: Solen
authors.initials: S
authors.lastname: Kernéis
authors.affiliation: Sorbonne Universités, UPMC Université Paris 06, INSERM, Institut Pierre-Louis d'Épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Turbelin
authors.affiliation: Dept. of Medicine, Div. of Rheumatology, Mount Sinai Hospital, Univ. of Toronto, Canada; and Assistance Publique-Hôpitaux de Paris, Dept.of Internal Medicine, Centre de Référence Maladies Rares-Vascularités et Sclérodermie, Hôpital Cochin, Paris, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Pagnoux
authors.affiliation: Université Paris-Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris; and Assistance Publique-Hôpitaux de Paris, Department of Infectious Diseases, CIC Cochin Pasteur, Hôpital Cochin, Paris; and Inserm CIC 1417, Paris, France.
authors.forename: Odile
authors.initials: O
authors.lastname: Launay
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Department of Internal Medicine, Hôpital Saint-Louis, Paris, France.
authors.forename: Alfred D
authors.initials: AD
authors.lastname: Mahr
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Department of Internal Medicine, Centre de Référence Maladies Rares-Vascularités et Sclérodermie, Hôpital Cochin, Paris, France.
authors.forename: Loïc
authors.initials: L
authors.lastname: Guillevin
authors.affiliation: Sorbonne Universités, UPMC Université Paris 06, INSERM, Institut Pierre-Louis d'Épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Boëlle
authors.affiliation: Sorbonne Univ., UPMC Univ. Paris 06, Inst. Pierre-Louis d'Épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris; Univ. Versailles Saint-Quentin-en-Yvelines; Hôp. de Paris, Dept.of Int. Medicine, Hôp. Ambroise-Paré, Boulogne-Billancourt, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hanslik
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications; D020407:Internet; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D056647:Systemic Vasculitis / Q000150:complications*; D014611:Vaccination