title: Clinical Evaluation of Human Umbilical Cord Mesenchymal Stem Cell Transplantation After Angioplasty for Diabetic Foot.
abstract: Aims:The multilineage differentiation potential of human umbilical cord mesenchymal stem cells (HUCMSCs) holds therapeutic promise for non-healing ulcers and tissue regeneration. The present study evaluated the effects of HUCMSC transplantation after angioplasty for treatment of diabetic foot.Methods:Included in the study were 53 patients (72 limbs) with severe symptoms of Fontaine II-IV diabetic foot accompanied by varying degrees of lower extremity arterial disease. The patients were randomly apportioned to a control group (25 patients; 38 limbs) or an experimental group (28 patients; 34 limbs). Patients of both groups received interventional treatment with angioplasty; those in the experimental group also received HUCMSCs by endovascular infusion and injection around the foot ulcer.Results:Within the 3-month follow-up, relative to patients in the control group, those in the experimental group experienced significantly greater and more stable improvements in skin temperature, ankle-brachial pressure index, transcutaneous oxygen tension, and claudication distance. Notably, 3 months after treatment a significant increase in neovessels, accompanied by complete or gradual ulcer healing, was shown in the experimental group. In addition, no serious complications or adverse reactions were associated with the treatment.Conclusion:Therefore, our results indicate that HUCMSC transplantation after angioplasty is a safe and effective clinical therapy for severe diabetic foot.
authors.affiliation: Department of Radiology, Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
authors.forename: H L
authors.initials: HL
authors.lastname: Qin
authors.affiliation: Department of Radiology, Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
authors.forename: X H
authors.initials: XH
authors.lastname: Zhu
authors.affiliation: Department of Ultrasound in Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: B
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
authors.forename: W Y
authors.initials: WY
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D064591:Allografts; D017130:Angioplasty; D017719:Diabetic Foot / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells; D008875:Middle Aged; D014470:Umbilical Cord