title: [Expressions of short palate, lung and nasal epithelium clone 1 in different human tissues].
abstract: OBJECTIVE
  To examine the expression patterns of short palate, lung and nasal epithelium clone 1 (SPLUNC1) gene in human tissues.
  
  
  METHODS
  In situ hybridization was used to detect the expression of SPLUNC1 gene in 37 different human tissues.
  
  
  RESULTS
  We found that SPLUNC1 gene was not expressed in squamous epithelial cells of the palate, epidermis, esophagus, or the esophagus-cardia junction, metaplastic squamous cells in the nasopharynx, trachea, or uterus cervix, or tumor cells of esophageal squamous cell carcinoma or lung squamous cell carcinoma. SPLUNC1 gene was not expressed in the single layer columnar epithelia cells in the stomach, gallbladder, jejunum, colon, endometrium, or uterus cervix. SPLUNC1 expression was detected mainly in pseudostratified columnar epithelial cells in the nasopharynx, trachea and bronchi, and was gradually down-regulated from the upper to lower end of the respiratory tract, but was not detected in the lung tissues. SPLUNC1 expression was detected not only in the duct and serous gland cells in the parotid and submandibular glands, but also in cells of submucosal serous glands in the nasopharynx and lung, but not in the cells of the mucosal glands. The parietal cells of the gastric submucosa and epithelial cells of the lobula and ducts of the mammary glands expressed SPLUNC1. The adenocarcinoma cells in the lung, stomach, colon, mammary gland, uterus endometrium and cervix showed strong expressions of SPLUNC1 gene.
  
  
  CONCLUSIONS
  SPLUNC1 expression is highly cell-specific in association with the cell functions.
authors.affiliation: Department of Pathology, 3Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.E-mail: shuangw@126.com.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.forename: Wen-Lu
authors.initials: WL
authors.lastname: Li
authors.forename: Li-Chun
authors.initials: LC
authors.lastname: Lü
authors.forename: Kai-Tai
authors.initials: KT
authors.lastname: Yao
mesh_terms: D004847:Epithelial Cells / Q000378:metabolism; D015870:Gene Expression; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009928:Organ Specificity; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C485599:BPIFA1 protein, human; D006023:Glycoproteins; D010750:Phosphoproteins