title: Numerical and ex vivo studies of a bioprobe developed for laser-induced thermotherapy (LITT) in contact with liver tissue.
abstract: This work is based on the production of a bioprobe that is compatible with magnetic resonance imaging (MRI) for laser-induced thermotherapy (LITT) in liver cancer laser therapy. This probe is made of an alumina tube (3-mm diameter) in which an optical fibre is centred and fixed. A shooting window (20mm) is created using a mechanical rectifier. The device is then consolidated by the injection of a transparent and heat-resistant resin. Through numerical modelling, the thermal power damping of the laser source is evaluated as well as the propagation of the heat in the ex vivo liver tissue according to different heating scenarios. These analyses allow for an estimation of the irradiated volume. Ex vivo tests were performed on bovine liver to confirm the adequacy of the bioprobe for LITT and of the irradiated volumes predicted by the numerical model. There was a difference of 8% between the simulations and ex vivo experiments. The pulsed mode heating scenario was the most effective under the experimental conditions.
authors.affiliation: Laboratoire de Génie Civil et géo-Environnement (LGCgE-EA 4515), Equipe Biomatériaux Artois, Université d'Artois, Béthune, France.
authors.forename: T
authors.initials: T
authors.lastname: Chartier
authors.affiliation: Laboratoire de Génie Civil et géo-Environnement (LGCgE-EA 4515), Equipe Biomatériaux Artois, Université d'Artois, Béthune, France.
authors.forename: O
authors.initials: O
authors.lastname: Carpentier
authors.affiliation: Laboratoire de Génie Civil et géo-Environnement (LGCgE-EA 4515), Equipe Biomatériaux Artois, Université d'Artois, Béthune, France.
authors.forename: B
authors.initials: B
authors.lastname: Genestie
authors.affiliation: Laboratoire des Matériaux Céramiques et Procédés Associés (LMCPA), Université de Valenciennes et du Hainaut Cambrésis F-59600 Maubeuge, France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Hornez
authors.affiliation: Laboratoire de Génie Civil et géo-Environnement (LGCgE-EA 4515), Equipe Biomatériaux Artois, Université d'Artois, Béthune, France. Electronic address: francine.monchau@univ-artois.fr.
authors.forename: F
authors.initials: F
authors.lastname: Monchau
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D002417:Cattle; D006979:Hyperthermia, Induced; D007834:Lasers; D008099:Liver / Q000166:cytology / Q000528:radiation effects*; D008954:Models, Biological
keywords: Heat distribution; Laser diffusing bioprobe; Laser-induced interstitial thermotherapy (LITT); Numerical modelling