title: Oocyte Quality in Patients with Increased FSH Levels.
abstract: OBJECTIVE
  The present study consists of quality comparison among oocytes retrieved from women under 37 years old showing increased levels of FSH (prone to premature ovarian insufficiency) and women at the same age with normal hormone levels.
  
  
  METHODS
  Oocyte quality was accessed according to Lucinda L. Veeck parameters (1986) and the statistical analyses were carried out using Chisquared, SPSS for Windows 13.0 (SPSS, Inc., Chicago, IL). All pvalues were twotailed, and 95% confidence intervals (CIs) were calculated. A P value <0.05 was considered statistically significant.
  
  
  RESULTS
  Eight morphologic changes variables were considered in the study and two of them showed statistically significant differences between cases and controls: granular cytoplasm (P=0.002) and presence of vacuoles (P=0.025), both more frequent among the study group patients.
  
  
  CONCLUSIONS
  As a conclusion, patients with increased FSH levels presented oocytes with worst quality variables than controls. This can be an indicative of ovarian aging and can impact negatively on oocyte development into viable embryos.
authors.affiliation: Instituto Ideia Fértil de Saúde Reprodutiva - Faculdade de Medicina do ABC.
authors.forename: Monise
authors.initials: M
authors.lastname: Santos
authors.affiliation: Instituto Ideia Fértil de Saúde Reprodutiva - Faculdade de Medicina do ABC.
authors.forename: Emerson Barchi
authors.initials: EB
authors.lastname: Cordts
authors.affiliation: Instituto Ideia Fértil de Saúde Reprodutiva - Faculdade de Medicina do ABC.
authors.forename: Bianca
authors.initials: B
authors.lastname: Bianco
authors.affiliation: Instituto Ideia Fértil de Saúde Reprodutiva - Faculdade de Medicina do ABC.
authors.forename: Caio Parente
authors.initials: CP
authors.lastname: Barbosa
authors.affiliation: Instituto Ideia Fértil de Saúde Reprodutiva - Faculdade de Medicina do ABC.
authors.forename: Denise Maria
authors.initials: DM
authors.lastname: Christofolini
keywords: FSH levels; Oocyte quality; Ovarian aging; Premature Ovarian Insufficiency