title: Effect of Morinda citrifolia (Noni) Fruit Juice on High Fat Diet Induced Dyslipidemia in Rats.
abstract: BACKGROUND
  The medicinal value of Morinda citrifolia L. (commonly known as Noni) has been explored in ancient folk remedies with a wide range of therapeutic utility, including antibacterial, antiviral, antifungal, antitumour, analgesic, hypotensive, anti-inflammatory and immune enhancing effects.
  
  
  OBJECTIVE
  The present study was designed to evaluate the effects of Noni fruit juice on serum lipid profile in high fat diet induced murine model of dyslipidemia.
  
  
  METHODS
  Hyperlipidemia was induced by feeding a cholesterol rich high fat diet for 45 days in wistar albino rats of either sex (n=8). Noni fruit juice administered at 50mg/kg/day and 100mg/kg/day, per oral, was compared with the standard drug Atorvastatin (10mg/kg/day, oral) fed for the latter 30 days. The blood samples were then sent for complete blood lipid profile, after 30 days of treatment. The data presented as mean ± SEM was analyzed using one-way ANOVA followed by Tukey's post-hoc test. The p <0.05 was considered as statistically significant.
  
  
  RESULTS
  The Noni fruit juice treated group showed a significant decrease in the total cholesterol, triglycerides and very low density lipoprotein - Cholesterol at both the doses when compared to the disease control (p<0.05). However, the decrease in the TC (102.75±9.79 mg/dL) and LDL-C (47.87±7.47 mg/dL) levels observed with the noni fruit juice at the 50mg/kg dose employed, failed to show a statistical significance when compared to atorvastatin.
  
  
  CONCLUSIONS
  The present study provides evidence for the hypolipidemic activity of Noni fruit juice in high fat diet induced hyperlipidemia in rats.
authors.affiliation: Post Graduate Student, Department of Pharmacology, Kasturba Medical College , Mangalore, Manipal University, Mangalore, Karnataka, India .
authors.forename: Ahsan
authors.initials: A
authors.lastname: Shoeb
authors.affiliation: Professor, Department of Pharmacology, Kasturba Medical College , Mangalore, Manipal University, Mangalore, Karnataka, India .
authors.forename: M C
authors.initials: MC
authors.lastname: Alwar
authors.affiliation: Associate Professor, Department of Pharmacology, Kasturba Medical College , Mangalore, Manipal University, Mangalore, Karnataka, India .
authors.forename: Preethi J
authors.initials: PJ
authors.lastname: Shenoy
authors.affiliation: Post Graduate Student, Department of Pharmacology, Kasturba Medical College , Mangalore, Manipal University, Mangalore, Karnataka, India .
authors.forename: P
authors.initials: P
authors.lastname: Gokul
keywords: High density lipoprotein; Hypolipidemic activity; Low density lipoprotein; Noni fruit; Plasma lipids; Total cholesterol; Very Low density lipoprotein