title: [Effects of IL10-592 locus of AA genotype on the incidence of aGVHD and survival after HLA-matched unrelated allogeneic hematopoietic stem cell transplantation].
abstract: OBJECTIVE
  To explore the impact of IL10-592 (rs1800872) single nucleic acid polymorphism (SNP) on the prognosis of HLA matched unrelated hematopoietic stem cell transplantation (HSCT).
  
  
  METHODS
  The polymorphism of IL10-592 in 104 recipient-donor pairs and 100 healthy volunteers was analyzed with sequence based typing (SBT).
  
  
  RESULTS
  When the genotype of IL10-592 in donors and recipients matched, AA/AA genotype had higher incidence of Ⅲ-Ⅳ aGVHD than AC/AC or CC/CC genotype (47.1%, 3.7%, 0, P=0.002). When the genotype of IL10-592 in donors and recipients mismatched, recipients with AC genotype or donors with AA genotype, there was significant different incidence of Ⅲ-ⅣaGVHD among donors or recipients with different genotype (P=0.046, P=0.041). The recipients with AA genotype had higher incidence of Ⅲ-Ⅳ aGVHD than AC or CC genotype (27.8% vs 10.2%, 11.1%; P=0.072), and higher incidence of intestinal aGVHD (22.2% vs 5.1%,11.1%; P=0.040) , lower incidence of 2-year overall survival (OS: 48.2% vs 75.1%, 85.7%; P=0.002), lower incidence of 2 year disease free survival (DFS: 48.5% vs 66.3%, 76.2%; P=0.045). Patients had higher incidence of Ⅲ-Ⅳ aGVHD with donors of AA genotype than with donors of AC or CC genotype (26.5% vs 8.9%, 0; P= 0.024), and higher incidence of intestinal aGVHD (20.4% vs 4.4%, 0; P=0.026). In multivariate analysis, the genotype of IL10-592AA in recipients and donors had increased risk of Ⅲ-Ⅳ aGVHD (OR=3.3, P= 0.049; OR=3.9, P=0.043). There were no statistical differences on the incidence of cGVHD and relapse.
  
  
  CONCLUSIONS
  In HLA-10/10 matched unrelated HSCT, the presence of IL10-592 AA genotype in recipients and/or donors is an adverse factor for Ⅲ-ⅣaGVHD, worse OS and 2-year DFS.
authors.affiliation: The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou 215006, China.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Yang
authors.forename: Q C
authors.initials: QC
authors.lastname: Qiu
authors.forename: Z X
authors.initials: ZX
authors.lastname: Ding
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Pan
authors.forename: Q Q
authors.initials: QQ
authors.lastname: Zhao
authors.forename: J
authors.initials: J
authors.lastname: He
mesh_terms: D018572:Disease-Free Survival; D005838:Genotype; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000235:genetics*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015994:Incidence; D016753:Interleukin-10 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011379:Prognosis; D014184:Transplantation, Homologous
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10