title: [INSULIN-LIKE GROWTH FACTOR-1: THE INFLUENCE ON THE LIVER FUNCTION AND RELATIONSHIPS WITH RESISTIN IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE AND ITS COMBINATION WITH TYPE 2 DIABETES MELLITUS].
abstract: The study was designed to assess the relationship between the level of plasma concentration of insulin-like growth factor-1 (IGF-1) and indices of the functional state of the liver and the level of resistin in patients with non-alcoholic fatty liver disease (NAFLD) and its combination with diabetes mellitus (DM) 2 types depending on the trophological status.
  
  
  METHODS
  It were examined 90 patients with non-alcoholic fatty liver disease and its combination with type 2 diabetes mellitus--with normal body weight and obesity, as well as 20 healthy individuals. The study was carried out using the following methods: clinical, laboratory and instrumental (including liver biopsy).
  
  
  RESULTS
  It was found an inverse relationship between the level of IGF-1, and the level of AST, ALT, AST/ALT, total and conjugated bilirubin, alkaline phosphatase in groups of patients with comorbid disorder and also an inverse relationship between the level of IGF-1 and resistin. There was established the significant decrease of plasma level of IGF-1, significant increase of plasma level of resistin and also impairment of liver function indices in all groups in comparison with the controls, and most pronounced changes in patients with comorbid disorders and obesity.
  
  
  CONCLUSIONS
  The established relationships suggests that the decrease of IGF-1 may represent the presence of syndromes of cytolysis and cholestasis in patients with NAFLD, type 2 DM and obesity. In order to determination the disorder of the reparative function of the liver is recommended to determine the level of IGF-1 in patients with combination of NAFLD and type 2 DM. Patients with the level of IGF-1 (< 143.9 ± 4.92 ng/ml) should refer to the risk of progression of liver function disorders. The inverse correlation between resistin levels and the level of IGF-1 in plasma confirms the existing relationship between their productions.
authors.forename: L V
authors.initials: LV
authors.lastname: Zhuravlyova
authors.forename: E V
authors.initials: EV
authors.lastname: Ogneva
authors.forename: A K
authors.initials: AK
authors.lastname: Zhuravlyova
mesh_terms: D000328:Adult; D048909:Diabetes Complications / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000150:complications; D052243:Resistin / Q000097:blood*
chemical_list: C583557:IGF1 protein, human; C499624:RETN protein, human; D052243:Resistin; D007334:Insulin-Like Growth Factor I