title: Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.
abstract: With the emergence of multidrug-resistant bacterial strains, there is a dire need for new drug targets for antibacterial drug discovery and development. Filamentous temperature sensitive protein Z (FtsZ), is a GTP-dependent prokaryotic cell division protein, sharing less than 10% sequence identity with the eukaryotic cell division protein, tubulin. FtsZ forms a dynamic Z-ring in the middle of the cell, leading to septation and subsequent cell division. Inhibition of the Z-ring blocks cell division, thus making FtsZ a highly attractive target. Various groups have been working on natural products and synthetic small molecules as inhibitors of FtsZ. This review summarizes the recent advances in the development of FtsZ inhibitors, focusing on those in the last 5years, but also includes significant findings in previous years.
authors.affiliation: Department of Chemistry, Stony Brook University, Stony Brook, NY, USA.
authors.forename: Krupanandan
authors.initials: K
authors.lastname: Haranahalli
authors.affiliation: Department of Chemistry, Stony Brook University, Stony Brook, NY, USA.
authors.forename: Simon
authors.initials: S
authors.lastname: Tong
authors.affiliation: Department of Chemistry, Stony Brook University, Stony Brook, NY, USA; Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, NY, USA. Electronic address: iwao.ojima@stonybrook.edu.
authors.forename: Iwao
authors.initials: I
authors.lastname: Ojima
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000737:chemistry / Q000166:cytology / Q000187:drug effects*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D003598:Cytoskeletal Proteins / Q000037:antagonists & inhibitors*; D055808:Drug Discovery; D006801:Humans; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; C071525:FtsZ protein, Bacteria
keywords: Antibacterial agent; Cell division; FtsZ; Inhibitor; Multidrug resistance; Septation; Z-ring protofilament