title: Can Chronic Pain Be Prevented?
abstract: All chronic pain begins at some discrete point in time. Significant strides in the understanding of mechanisms and risk factors associated with the transition from a new, or acute, pain experience to a chronic pain condition have been made over the past 20 years. These insights provide the hope of one day being able to modify or even halt this pathophysiologic progression. This article reviews some of the current knowledge of this transition as well as the evidence currently available to best prevent and treat it using persistent surgical pain as a model.
authors.affiliation: Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Penn Pain Medicine Center, 1840 South Street, Philadelphia, PA 19146, USA. Electronic address: Ignacio.badiola@uphs.upenn.edu.
authors.forename: Ignacio J
authors.initials: IJ
authors.lastname: Badiola
mesh_terms: D059787:Acute Pain / Q000150:complications*; D000588:Amines / Q000627:therapeutic use; D000765:Anesthesia, Conduction; D059350:Chronic Pain / Q000517:prevention & control*; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D044127:Epigenesis, Genetic; D000077206:Gabapentin; D006801:Humans; D007649:Ketamine / Q000627:therapeutic use; D010149:Postoperative Pain / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*; D000069583:Pregabalin / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use
chemical_list: D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D007649:Ketamine; D000077206:Gabapentin
keywords: Acute to chronic pain transition; Chronic pain; Genetics of chronic pain; Multimodal analgesia; Persistent postsurgical pain