title: PreSurgMapp: a MATLAB Toolbox for Presurgical Mapping of Eloquent Functional Areas Based on Task-Related and Resting-State Functional MRI.
abstract: The main goal of brain tumor surgery is to maximize tumor resection while minimizing the risk of irreversible postoperative functional sequelae. Eloquent functional areas should be delineated preoperatively, particularly for patients with tumors near eloquent areas. Functional magnetic resonance imaging (fMRI) is a noninvasive technique that demonstrates great promise for presurgical planning. However, specialized data processing toolkits for presurgical planning remain lacking. Based on several functions in open-source software such as Statistical Parametric Mapping (SPM), Resting-State fMRI Data Analysis Toolkit (REST), Data Processing Assistant for Resting-State fMRI (DPARSF) and Multiple Independent Component Analysis (MICA), here, we introduce an open-source MATLAB toolbox named PreSurgMapp. This toolbox can reveal eloquent areas using comprehensive methods and various complementary fMRI modalities. For example, PreSurgMapp supports both model-based (general linear model, GLM, and seed correlation) and data-driven (independent component analysis, ICA) methods and processes both task-based and resting-state fMRI data. PreSurgMapp is designed for highly automatic and individualized functional mapping with a user-friendly graphical user interface (GUI) for time-saving pipeline processing. For example, sensorimotor and language-related components can be automatically identified without human input interference using an effective, accurate component identification algorithm using discriminability index. All the results generated can be further evaluated and compared by neuro-radiologists or neurosurgeons. This software has substantial value for clinical neuro-radiology and neuro-oncology, including application to patients with low- and high-grade brain tumors and those with epilepsy foci in the dominant language hemisphere who are planning to undergo a temporal lobectomy.
authors.affiliation: Center for Cognition and Brain Disorders, Hangzhou Normal University, 58 Haishu Road, Hangzhou, 311121, People's Republic of China.|School of Education Science, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, People's Republic of China.|Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, 310015, People's Republic of China.
authors.forename: Huiyuan
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310014, People's Republic of China.
authors.forename: Zhongxiang
authors.initials: Z
authors.lastname: Ding
authors.affiliation: Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310014, People's Republic of China.
authors.forename: Dewang
authors.initials: D
authors.lastname: Mao
authors.affiliation: Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310014, People's Republic of China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310014, People's Republic of China.
authors.forename: Fangmei
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Department of Neurosurgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310014, People's Republic of China.
authors.forename: Shuda
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310014, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310014, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lou
authors.affiliation: Department of Neurosurgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, 310014, People's Republic of China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Radiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, 310015, People's Republic of China.
authors.forename: Le
authors.initials: L
authors.lastname: Qi
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, 310015, People's Republic of China.
authors.forename: Wusi
authors.initials: W
authors.lastname: Qiu
authors.affiliation: Center for Cognition and Brain Disorders, Hangzhou Normal University, 58 Haishu Road, Hangzhou, 311121, People's Republic of China. hanzhang@hznu.edu.cn.|Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, 310015, People's Republic of China. hanzhang@hznu.edu.cn.
authors.forename: Han
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Center for Cognition and Brain Disorders, Hangzhou Normal University, 58 Haishu Road, Hangzhou, 311121, People's Republic of China.|Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, 310015, People's Republic of China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Zang
mesh_terms: D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011300:Preoperative Care; D012815:Signal Processing, Computer-Assisted; D012984:Software
keywords: Brain tumor; Eloquent functional areas; Functional magnetic resonance imaging (fMRI); Preoperative mapping; Presurgical planning; Resting state; Toolbox