title: Aerobic Copper-Mediated Domino Three-Component Approach to 2-Aminobenzothiazole Derivatives.
abstract: An unprecedented three-component reaction involving a 2,2'-diaminodiaryl disulfide, copper cyanide, and an electrophile is described. This transformation is based on an oxidative copper-mediated S-cyanation as a key step and involves a cyanation/cyclization/acylation domino sequence enabling a rapid and efficient synthesis of diversely substituted 2-aminobenzothiazole derivatives. Notably, this reaction proceeds via an original mechanism involving an intermolecular migration of the acyl group.
authors.affiliation: Laboratoire d'Innovation Thérapeutique (UMR 7200), Faculté de Pharmacie, Université de Strasbourg, CNRS , 74 Route du Rhin, 67401 Illkirch, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Castanheiro
authors.affiliation: Laboratoire d'Innovation Thérapeutique (UMR 7200), Faculté de Pharmacie, Université de Strasbourg, CNRS , 74 Route du Rhin, 67401 Illkirch, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Suffert
authors.affiliation: Laboratoire d'Innovation Thérapeutique (UMR 7200), Faculté de Pharmacie, Université de Strasbourg, CNRS , 74 Route du Rhin, 67401 Illkirch, France.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Gulea
authors.affiliation: Laboratoire d'Innovation Thérapeutique (UMR 7200), Faculté de Pharmacie, Université de Strasbourg, CNRS , 74 Route du Rhin, 67401 Illkirch, France.
authors.forename: Morgan
authors.initials: M
authors.lastname: Donnard