title: Seroprevalence of total antibodies to hepatitis A virus in haemophiliacs in the West of Scotland.
abstract: Serum samples taken from 73 patients with haemophilia A were tested for the presence of total antibody against hepatitis A (antiHAV) by radiommunoassay. 29 (39.7%) were antiHAV positive and 44 (60.3%) were antiHAV negative. These figures are comparable with local prevalence figures for immunity (40.3%) and susceptibility (59.7%) to HAV in adults. 30 patients were subsequently exposed to Scottish National Blood Transfusion Service High-Purity Factor VIII (SNBTS HPVIII). They were re-tested for the presence of antiHAV at a median of 5 months after exposure. Of these, 25 (83.3%) were antiHAV negative and five (16.7%) were antiHAV positive. All five of these antiHAV-positive patients were positive on samples taken prior to exposure. No cases of seroconversion to hepatitis A occurred.
authors.affiliation: Career Registrar, University Department of Haematology, Western Infirmary, Dumbarton Road, Glasgow G11 6NT.Clinical Scientist, Department of Virology, Runchill Hospital, Glasgow.Co-Director, Haemophilia Unit, Royal Infirmary, Glasgow.Co-Director, Haemophilia Unit, Royal Infirmary, Glasgow.
authors.forename: P
authors.initials: P
authors.lastname: Clark
authors.affiliation: Career Registrar, University Department of Haematology, Western Infirmary, Dumbarton Road, Glasgow G11 6NT.Clinical Scientist, Department of Virology, Runchill Hospital, Glasgow.Co-Director, Haemophilia Unit, Royal Infirmary, Glasgow.Co-Director, Haemophilia Unit, Royal Infirmary, Glasgow.
authors.forename: S O
authors.initials: SO
authors.lastname: Cameron
authors.affiliation: Career Registrar, University Department of Haematology, Western Infirmary, Dumbarton Road, Glasgow G11 6NT.Clinical Scientist, Department of Virology, Runchill Hospital, Glasgow.Co-Director, Haemophilia Unit, Royal Infirmary, Glasgow.Co-Director, Haemophilia Unit, Royal Infirmary, Glasgow.
authors.forename: I D
authors.initials: ID
authors.lastname: Walker
authors.affiliation: Career Registrar, University Department of Haematology, Western Infirmary, Dumbarton Road, Glasgow G11 6NT.Clinical Scientist, Department of Virology, Runchill Hospital, Glasgow.Co-Director, Haemophilia Unit, Royal Infirmary, Glasgow.Co-Director, Haemophilia Unit, Royal Infirmary, Glasgow.
authors.forename: G D
authors.initials: GD
authors.lastname: Lowe
keywords: Hepatitis A; haemophilia