title: Quinine unbound concentration is the best marker for therapeutic drug monitoring.
abstract: Quinine monitoring should be based on unbound concentration due to variable unbound fraction in malaria patients.
authors.affiliation: Pharmacokinetics and toxicology laboratory, federative institute of biology, Purpan university hospital, 31000 Toulouse, France.
authors.forename: Carlos
authors.initials: C
authors.lastname: de Pablos-Martinez
authors.affiliation: Infectious diseases department, Purpan university hospital, 31000 Toulouse, France.
authors.forename: Lydie
authors.initials: L
authors.lastname: Porte
authors.affiliation: Pharmacokinetics and toxicology laboratory, federative institute of biology, Purpan university hospital, 31000 Toulouse, France.
authors.forename: François
authors.initials: F
authors.lastname: Fraissinet
authors.affiliation: Parasitology laboratory, federative institute of biology, Purpan university hospital, 31000 Toulouse, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Berry
authors.affiliation: Pharmacokinetics and toxicology laboratory, federative institute of biology, Purpan university hospital, 31000 Toulouse, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Séraissol
authors.affiliation: Pharmacokinetics and toxicology laboratory, federative institute of biology, Purpan university hospital, 31000 Toulouse, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Lavit
authors.affiliation: EA4553 pharmacology and pharmacogenetic laboratory, university institute of cancer (Oncopôle), 31000 Toulouse, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Chatelut
authors.affiliation: UMR1331-TOXALIM, Toulouse veterinary school, 31000 Toulouse, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Concordet
authors.affiliation: Pharmacokinetics and toxicology laboratory, federative institute of biology, Purpan university hospital, 31000 Toulouse, France; EA4553 pharmacology and pharmacogenetic laboratory, university institute of cancer (Oncopôle), 31000 Toulouse, France. Electronic address: gandia.p@chu-toulouse.fr.
authors.forename: Peggy
authors.initials: P
authors.lastname: Gandia
mesh_terms: D000962:Antimalarials / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D016903:Drug Monitoring; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D011485:Protein Binding; D011803:Quinine / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000962:Antimalarials; D011803:Quinine
keywords: Fraction libre; Quinine; Suivi pharmacologique thérapeutique; Therapeutic drug monitoring; Unbound fraction