title: Comparative B-mode and Doppler renal ultrasonography with histopathological findings in dogs positive for canine visceral leishmaniasis.
abstract: Morphological parameters and renal flow were assessed and measured in six clinically healthy dogs with negative serological and parasitological examinations for canine visceral leishmaniasis (CVL) and six dogs with CVL-positive serological and parasitological tests and asymptomatic condition of the disease. Kidney length and diameter were measured and compared with the aorta/kidney ratio. Alterations in flow were measured using the flow velocity (cm/s) and resistance index (RI). Renal function was assessed by serum biochemical examination (urea, creatine, total proteins, albumin, and globulin) and urinalysis. CVL-positive animals presented heterogeneous kidney echotexture, reduced vascular flow, hypoperfusion, lesser visualization of the arcuate arteries, high RI values (1.06 ± 0.28 for the right kidney and 1.10 ± 0.30 for the left kidney), reduced diastolic flow, and high systolic peak. They also presented positive creatine/RI correlation and between the renal artery vascular flow and kidney diameter. Histopathological analysis of CVL-positive animals was compatible and confirmed hemodynamic changes observed by Doppler ultrasound. The findings in the present study showed that Doppler ultrasonography is a valid method to assess and detect alterations in flow in renal pathological processes with kidney vascular damage, as in the case of leishmaniasis, and can help in the diagnosis of animals with this infection. Microsc. Res. Tech. 79:637-645, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Animal Science Post-Graduate Program, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil.
authors.forename: Pollyana Irene
authors.initials: PI
authors.lastname: Baltazar
authors.affiliation: Animal Science Post-Graduate Program, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil.
authors.forename: Laecio
authors.initials: L
authors.lastname: Da Silva Moura
authors.affiliation: Animal Science Post-Graduate Program, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil.
authors.forename: Gerson Tavares
authors.initials: GT
authors.lastname: Pessoa
authors.affiliation: Graduate of Veterinary Medicine, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil.
authors.forename: Renan Paraguassu
authors.initials: RP
authors.lastname: De Sá Rodrigues
authors.affiliation: Graduate of Veterinary Medicine, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil.
authors.forename: Marina Pinto
authors.initials: MP
authors.lastname: Sanches
authors.affiliation: Animal Science Post-Graduate Program, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil.
authors.forename: Anaemilia
authors.initials: A
authors.lastname: Das Neves Diniz
authors.affiliation: Animal Science Post-Graduate Program, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil.
authors.forename: Francisco
authors.initials: F
authors.lastname: Das Chagas Araújo Sousa
authors.affiliation: Health Department Clinics, State University of Maranhão, Campus Paulo VI, São Luís, Maranhão, 65055-310, Brazil.
authors.forename: Porfírio Candanedo
authors.initials: PC
authors.lastname: Guerra
authors.affiliation: Department of Morphophysiology, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil.
authors.forename: Willams Costa
authors.initials: WC
authors.lastname: Neves
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, 32610.
authors.forename: Robson Fortes
authors.initials: RF
authors.lastname: Giglio
authors.affiliation: Surgery Post-Graduate Program, Federal University of Ceará, Avenida Da Universidade, Fortaleza, Ceará, 60020-181, Brazil.
authors.forename: Jacyara
authors.initials: J
authors.lastname: De Jesus Rosa Pereira Alves
authors.affiliation: Department of Morphology and Animal Physiology, Federal University of Pernambuco, Recife, Pernambuco, 52171-900, Brazil.
authors.forename: Francisco
authors.initials: F
authors.lastname: De Assis Leite Souza
authors.affiliation: Department of Clinical and Veterinary Surgery, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, 30161-970, Brazil.
authors.forename: Juliana Fortes Vilarinho
authors.initials: JF
authors.lastname: Braga
authors.affiliation: Department of Morphophysiology, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil.
authors.forename: Flávio Ribeiro
authors.initials: FR
authors.lastname: Alves
mesh_terms: D000818:Animals; D004285:Dogs; D007668:Kidney / Q000000981:diagnostic imaging* / Q000473:pathology*; D007898:Leishmaniasis, Visceral / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D018608:Ultrasonography, Doppler / Q000379:methods
keywords: CVL; renal failure; renal ultrasound