title: [Cardiac sarcoidosis: Diagnosis and therapeutic challenges].
abstract: Sarcoidosis is a granulomatous disorder of unknown cause characterized by non-caseating granuloma in young adults. Cardiac involvement is rare and range from 2 to 75% depending on diagnostic criteria. Cardiac involvement in sarcoidosis may be asymptomatic or may manifest as rhythm/conduction troubles or congestive heart failure. The diagnosis and treatment of cardiac sarcoidosis may be challenging. However, advances have come in recent years from the use of cardiac MRI and18FDG-TEP scanner, as well as from the stratification of the risk of ventricular tachycardia/fibrillation. Due to the rarity of the disease, there is no reliable prospective large study to guide therapeutic strategy for cardiac sarcoidosis. Corticosteroids are probably efficacious, in particular in case of atrio-ventricular block or moderate heart failure. Immunosuppressive drugs have not been largely studied but methotrexate could be helpful. In refractory forms, TNF-α antagonists have been used with success.
authors.affiliation: Service de médecine interne, institut E3M, groupe hospitalier Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France; Université Paris VI Pierre-et-Marie-Curie, Sorbonne universités, 75013 Paris, France. Electronic address: fleur.cohen@psl.aphp.fr.
authors.forename: F
authors.initials: F
authors.lastname: Cohen Aubart
authors.affiliation: Service de pneumologie, hôpital Avicenne, AP-HP, université Paris XIII, 93000 Bobigny, France.
authors.forename: H
authors.initials: H
authors.lastname: Nunes
authors.affiliation: Service de médecine interne, institut E3M, groupe hospitalier Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France; Université Paris VI Pierre-et-Marie-Curie, Sorbonne universités, 75013 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Mathian
authors.affiliation: Service de médecine interne, institut E3M, groupe hospitalier Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France; Université Paris VI Pierre-et-Marie-Curie, Sorbonne universités, 75013 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Haroche
authors.affiliation: Service de médecine interne, institut E3M, groupe hospitalier Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France.
authors.forename: M
authors.initials: M
authors.lastname: Hié
authors.affiliation: Service de médecine interne, institut E3M, groupe hospitalier Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France; Université Paris VI Pierre-et-Marie-Curie, Sorbonne universités, 75013 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Le-Thi Huong Boutin
authors.affiliation: Université Paris VI Pierre-et-Marie-Curie, Sorbonne universités, 75013 Paris, France; Service de radiologie, groupe hospitalier Pitié-Salpêtrière, AP-HP, 75651 Paris cedex 13, France.
authors.forename: P
authors.initials: P
authors.lastname: Cluzel
authors.affiliation: Service de médecine nucléaire, hôpital Avicenne, AP-HP, 93000 Bobigny, France.
authors.forename: M
authors.initials: M
authors.lastname: Soussan
authors.affiliation: Service de cardiologie, unité de rythmologie, groupe hospitalier Pitié-Salpêtrière, AP-HP, 75651 Paris cedex 13, France.
authors.forename: X
authors.initials: X
authors.lastname: Waintraub
authors.affiliation: Université Paris VI Pierre-et-Marie-Curie, Sorbonne universités, 75013 Paris, France; Service d'anatomo-pathologie, groupe hospitalier Pitié-Salpêtrière, AP-HP, 75651 Paris cedex 13, France.
authors.forename: P
authors.initials: P
authors.lastname: Fouret
authors.affiliation: Service de pneumologie, hôpital Avicenne, AP-HP, université Paris XIII, 93000 Bobigny, France.
authors.forename: D
authors.initials: D
authors.lastname: Valeyre
authors.affiliation: Service de médecine interne, institut E3M, groupe hospitalier Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France; Université Paris VI Pierre-et-Marie-Curie, Sorbonne universités, 75013 Paris, France.
authors.forename: Z
authors.initials: Z
authors.lastname: Amoura
mesh_terms: D000328:Adult; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D003937:Diagnosis, Differential; D006801:Humans; D015995:Prevalence; D012507:Sarcoidosis / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D055815:Young Adult
keywords: Corticosteroids; Corticostéroïdes; Cœur; Heart; Rhythm and conduction troubles; Sarcoidosis; Sarcoïdose; Troubles du rythme