title: Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus.
abstract: Preclinical development of and research on potential Middle East respiratory syndrome coronavirus (MERS-CoV) medical countermeasures remain preliminary; advancements are needed before most countermeasures are ready to be tested in human clinical trials. Research priorities include standardization of animal models and virus stocks for studying disease pathogenesis and efficacy of medical countermeasures; development of MERS-CoV diagnostics; improved access to nonhuman primates to support preclinical research; studies to better understand and control MERS-CoV disease, including vaccination studies in camels; and development of a standardized clinical trial protocol. Partnering with clinical trial networks in affected countries to evaluate safety and efficacy of investigational therapeutics will strengthen efforts to identify successful medical countermeasures.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Uyeki
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Erlandson
authors.forename: George
authors.initials: G
authors.lastname: Korch
authors.forename: Michael
authors.initials: M
authors.lastname: O'Hara
authors.forename: Michael
authors.initials: M
authors.lastname: Wathen
authors.forename: Jean
authors.initials: J
authors.lastname: Hu-Primmer
authors.forename: Sally
authors.initials: S
authors.lastname: Hojvat
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Stemmy
authors.forename: Armen
authors.initials: A
authors.lastname: Donabedian
mesh_terms: D000818:Animals; D002162:Camelus; D018352:Coronavirus Infections / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D004195:Disease Models, Animal; D006801:Humans; D065207:Middle East Respiratory Syndrome Coronavirus; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D014765:Viral Vaccines
keywords: MERS-CoV; Middle East respiratory syndrome coronavirus; animal models; antibodies; antivirals; diagnostics; medical countermeasures; monoclonal; non-human primates; nonhuman primates; polyclonal; respiratory infections; therapeutics; vaccines; viruses