title: Evidence supporting the conceptual framework of cancer chemoprevention in canines.
abstract: As with human beings, dogs suffer from the consequences of cancer. We investigated the potential of a formulation comprised of resveratrol, ellagic acid, genistein, curcumin and quercetin to modulate biomarkers indicative of disease prevention. Dog biscuits were evaluated for palatability and ability to deliver the chemopreventive agents. The extent of endogenous DNA damage in peripheral blood lymphocytes from dogs given the dietary supplement or placebo showed no change. However, H2O2-inducible DNA damage was significantly decreased after consumption of the supplement. The expression of 11 of 84 genes related to oxidative stress was altered. Hematological parameters remained in the reference range. The concept of chemoprevention for the explicit benefit of the canine is compelling since dogs are an important part of our culture. Our results establish a proof-of-principle and provide a framework for improving the health and well-being of "man's best friend".
authors.affiliation: Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA.
authors.forename: Tamara P
authors.initials: TP
authors.lastname: Kondratyuk
authors.affiliation: Department of Pharmacy Practice, The Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA.
authors.forename: Julie Ann Luiz
authors.initials: JA
authors.lastname: Adrian
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois, 833 S. Wood Street, Chicago, IL 60612, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Wright
authors.affiliation: Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA.
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Park
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois, 833 S. Wood Street, Chicago, IL 60612, USA.
authors.forename: Richard B
authors.initials: RB
authors.lastname: van Breemen
authors.affiliation: Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA.
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Morris
authors.affiliation: Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Pezzuto
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000494:pharmacology; D018890:Chemoprevention; D003474:Curcumin / Q000008:administration & dosage / Q000494:pharmacology; D004249:DNA Damage / Q000187:drug effects*; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D004610:Ellagic Acid / Q000008:administration & dosage / Q000494:pharmacology; D005526:Food, Formulated; D019833:Genistein / Q000008:administration & dosage / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000009:adverse effects; D009369:Neoplasms / Q000517:prevention & control / Q000662:veterinary*; D018384:Oxidative Stress; D011794:Quercetin / Q000008:administration & dosage / Q000494:pharmacology; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology; D016896:Treatment Outcome
chemical_list: D013267:Stilbenes; D004610:Ellagic Acid; D011794:Quercetin; D006861:Hydrogen Peroxide; D019833:Genistein; D003474:Curcumin; D000077185:Resveratrol