title: Catalytic Chemo- and Regioselective Coupling of 1,3-Dicarbonyls with N-Heterocyclic Nucleophiles.
abstract: The development of a decarboxylative palladium-catalyzed coupling of 1,3-dicarbonyl compounds with indole, pyrrole, imidazole, and pyrazole nucleophiles via an allylic linker under neutral conditions is disclosed. This process enables the installation of an all-carbon quaternary center and new C-C and C-N bonds in a single operation. Despite the weakly acidic nature of N-heterocycles, the reactions proceed with good efficiency and complete regio- and chemoselectivity.
authors.affiliation: Department of Chemistry, Lancaster University , Lancaster LA1 4YB, United Kingdom.
authors.forename: Miles
authors.initials: M
authors.lastname: Kenny
authors.affiliation: Department of Chemistry, Lancaster University , Lancaster LA1 4YB, United Kingdom.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Kitson
authors.affiliation: Department of Chemistry, Lancaster University , Lancaster LA1 4YB, United Kingdom.
authors.forename: Vilius
authors.initials: V
authors.lastname: Franckevičius