title: Virulence and Experimental Treatment of Trichoderma longibrachiatum, a Fungus Refractory to Treatment.
abstract: Different inocula of Trichoderma longibrachiatum were tested in a murine model, and only the highest one (1 × 10(7) CFU/animal) killed all of the mice at day 15 postinfection, with spleen and liver the most affected organs. The efficacies of amphotericin B deoxycholate, liposomal amphotericin B, voriconazole, and micafungin were evaluated in the same model, with very poor results. Our study demonstrated the low virulence but high resistance to antifungal compounds of this fungus.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: Katihuska
authors.initials: K
authors.lastname: Paredes
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain javier.capilla@urv.cat.
authors.forename: Javier
authors.initials: J
authors.lastname: Capilla
authors.affiliation: Unitat d'Anatomia Patològica, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Mayayo
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D003840:Deoxycholic Acid / Q000627:therapeutic use; D004338:Drug Combinations; D054714:Echinocandins / Q000627:therapeutic use; D055666:Lipopeptides / Q000627:therapeutic use; D008099:Liver / Q000382:microbiology; D008297:Male; D000077551:Micafungin; D051379:Mice; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology; D013154:Spleen / Q000382:microbiology; D014242:Trichoderma / Q000187:drug effects* / Q000472:pathogenicity*; D014774:Virulence / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D054714:Echinocandins; D055666:Lipopeptides; C068538:liposomal amphotericin B; D003840:Deoxycholic Acid; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination; D000077551:Micafungin