title: Protective effects of dexmedetomidine on brain function of glioma patients undergoing craniotomy resection and its underlying mechanism.
abstract: BACKGROUND
  To explore the protective effects of dexmedetomidine on brain of glioma patients undergoing craniotomy resection and its underlying mechanism.
  
  
  METHODS
  60 cases of patients undergoing craniotomy resection of glioma were randomly divided into group C (n=30) and D (n=30). D group patients received dexmedetomidine vein pump injection at a dose of 1μg/kg 10min before anesthesia induction, with a maintain dose of 0.4μg/(kg/h). Group C patients received saline instead. Mean arterial pressure (MAP) and heart rate (heart rate, HR) were compared between the two groups of patients before anesthesia induction (T1), before tracheal intubation (T2), immediately after tracheal intubation (T3), 1min after tracheal intubation (T4), 3min after tracheal intubation (T5), 5min after tracheal intubation (T6). Expression levels of serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), superoxide dismutase (SOD), malondialdehyde (MDA), neuron-specific enolase of Enzyme (NSE) and S100β were compared between the two groups of patients before surgery, immediately post-surgery and 24h post-surgery.
  
  
  RESULTS
  No significant differences of MAP and HR between the two groups were found at T1, T2, T5 and T6 (P>0.05); The levels of MAP and HR in group C were significantly higher than those in group D at T3 and T4 (P<0.05). No significant differences of preoperative expression levels of serum TNF-α, IL-6, NSE, S100β, SOD and MDA were found between the two groups (P>0.05); Serum levels of TNF-α, IL-6, NSE, S100β and MDA were significantly reduced, whereas SOD was significantly increased in group D compared with those in group C at surgery time and 24h post-surgery (P<0.05).
  
  
  CONCLUSIONS
  Dexmedetomidine can significantly stabilize hemodynamics, reduce inflammation, and inhibit free radical generation, thus plays an important role on brain protection in patients undergoing craniotomy resection of glioma.
authors.affiliation: Department of Anesthesiology, Yongchuan Hospital, Chongqing Medical University, China.
authors.forename: Xiahong
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Anesthesiology, Yongchuan Hospital, Chongqing Medical University, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Department of Anesthesiology, Yongchuan Hospital, Chongqing Medical University, China. Electronic address: hougang_mazui@foxmail.com.
authors.forename: Hougang
authors.initials: H
authors.lastname: Huang
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000097:blood* / Q000601:surgery*; D003399:Craniotomy / Q000379:methods*; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005910:Glioma / Q000097:blood* / Q000601:surgery*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D017063:Outcome Assessment, Health Care
chemical_list: D006993:Hypnotics and Sedatives; D018696:Neuroprotective Agents; D020927:Dexmedetomidine
keywords: Brain protection; Dexmedetomidine; Glioma