title: "Hockey Stick" may Strike Back: Hepatocellular Carcinoma on Noncirrhotic Liver as a Late Toxicity of Lombo-Aortic Radiotherapy for Seminoma. A Review Triggered by an Unusual Case.
abstract: Most patients with testicular seminoma have been treated with a curative intent for decades. Second cancers after radiotherapy for testicular seminoma before 1990 are a growing issue, and are related to previous generation of dose planning and delineating strategies. Among those cancers, hepatocellular carcinoma is an extremely rare occurrence, especially when affecting patients with healthy, noncirrhotic liver. Here, we describe such a case in a patient of our institution, and subsequently review the relevant literature and large epidemiologic studies. Understanding those late and serious toxicity features may help cancer care teams to screen and treat those patients appropriately.
authors.affiliation: Department of Oncology, University Hospital of Strasbourg, Strasbourg, France.
authors.forename: Clement
authors.initials: C
authors.lastname: Korenbaum
authors.affiliation: Department of Oncology, University Hospital of Strasbourg, Strasbourg, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Barthelemy
authors.affiliation: Department of Oncology, University Hospital of Strasbourg, Strasbourg, France; Department of Radiotherapy, Paul Strauss Cancer Center, Strasbourg, France.
authors.forename: Alina
authors.initials: A
authors.lastname: Onea
authors.affiliation: Department of Radiotherapy, Paul Strauss Cancer Center, Strasbourg, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Salze
authors.affiliation: Department of Oncology, University Hospital of Strasbourg, Strasbourg, France.
authors.forename: Jean-Emmanuel
authors.initials: JE
authors.lastname: Kurtz
keywords: CT, computed tomography; NASH, nonalcoholic steato-hepatitis; SEER, Surveillance, Epidemiology and End Results; TGCT, testicular germ cell tumor; US, ultrasound; hepatocellular carcinoma; noncirrhotic liver; radiation-induced cancer; seminoma