title: Role of human papillomavirus and tumor suppressor genes in oral cancer.
abstract: The incidence of oral cancer remains high and is associated with many deaths in both Western and Asian countries. Several risk factors for the development of oral cancer are now well known, including smoking, drinking and consumption of smokeless tobacco products. Genetic predisposition to oral cancer has been found in certain cases, but its components are not yet entirely clear. In accordance with the multi-step theory of carcinogenesis, the natural history of oral cancer seems to gradually evolve through transitional precursor lesions from normal epithelium to a full-blown metastatic phenotype. A number of genomic lesions accompany this transformation and a wealth of related results has appeared in recent literature and is being summarized here. Furthermore, several key genes have been implicated, especially well-known tumor suppressors such as the cyclin-dependent kinase inhibitors, TP53 and RB1 and oncogenes such as the cyclin family, epidermal growth factor receptor and RAS. Viral infections, particularly oncogenic human papillomavirus subtypes and Epstein-Barr virus, can have a tumorigenic effect on oral epithelia and their role is discussed, along with potential therapeutic interventions. A brief explanatory theoretical model of oral carcinogenesis is provided and potential avenues for further research are highlighted.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Navodaya Dental College, Raichur, Karnataka, India.
authors.forename: Vardendra
authors.initials: V
authors.lastname: Manvikar
authors.affiliation: General Dentist, Sri Jagannatha Vittala Dental Clinic, Raichur, Karnataka, India.
authors.forename: Rama
authors.initials: R
authors.lastname: Kulkarni
authors.affiliation: Department of Oral Pathology, Navodaya Dental College and Hospital, Raichur, Karnataka, India.
authors.forename: Anila
authors.initials: A
authors.lastname: Koneru
authors.affiliation: Department of Oral Pathology, Navodaya Dental College and Hospital, Raichur, Karnataka, India.
authors.forename: M
authors.initials: M
authors.lastname: Vanishree
keywords: Epstein–Barr virus; human papillomavirus; oncogenes; oral cancer; tumor suppressor genes