title: The Geriatric Nutritional Risk Index Predicts Survival in Elderly Esophageal Squamous Cell Carcinoma Patients with Radiotherapy.
abstract: The impact of nutritional status on survival among elderly esophageal squamous cell carcinoma (ESCC) patients undergoing radiotherapy is unclear. In this study, we aimed at validating the performance of the geriatric nutritional risk index (GNRI) in predicting overall survival time in elderly ESCC patients with radiotherapy. A retrospective cohort study was conducted on 239 ESCC patients aged 60 and over admitted consecutively from January 2008 to November 2014 in the Department of Radiotherapy, Henan Tumor Hospital (Affiliated Tumor Hospital of Zhengzhou University), Zhengzhou, Henan, China. All patients were subjected to nutritional screening using GNRI, and were followed for the occurrence of lymphatic node metastasis, radiation complication and mortality. The Kaplan-Meier method with Log-rank test was used to estimate survival curves. Univariable Cox regression analysis was used to identify variables associated with overall survival time. Among the 239 patients, 184 patients (76.9%) took no nutritional risk, 32 patients (13.4%) took moderate risk of malnutrition, and 23 patients (9.7%) took a high risk of malnutrition. Univariable Cox regression showed that both high nutritional risk group and moderate nutritional risk group were significantly less likely to survive than no nutritional risk patients (hazard ratio (HR) = 1.688, 95% confidence interval (CI) = 1.019-2.798 for moderate risk group, and HR = 2.699, 95% CI = 1.512-4.819 for high risk group, respectively). The GNRI is an independent prognostic factor for overall survival time in elderly ESCC patients with radiotherapy. A GNRI ≤98 can be suggested as an indicator of surviving less.
authors.affiliation: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.|Department of radiotherapy, Henan Tumor Hospital, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Yacong
authors.identifier: 0000-0001-7306-9971
authors.initials: Y
authors.lastname: Bo
authors.affiliation: Department of radiotherapy, Henan Tumor Hospital, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Kunlun
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of radiotherapy, Henan Tumor Hospital, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
authors.forename: Jie
authors.initials: J
authors.lastname: You
authors.affiliation: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
authors.forename: Han
authors.initials: H
authors.lastname: Cui
authors.affiliation: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
authors.forename: Quanjun
authors.identifier: 0000-0002-0808-3758
authors.initials: Q
authors.lastname: Lu
authors.affiliation: Department of radiotherapy, Henan Tumor Hospital, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yuan
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000473:pathology / Q000532:radiotherapy; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000453:epidemiology*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D015596:Nutrition Assessment; D012306:Risk; D016019:Survival Analysis