title: Androgen receptor CAG polymorphism and sporadic and early-onset prostate cancer among Mexican men.
abstract: A short CAG repeat length in the gene encoding for the androgen receptor (AR) has been associated with prostate cancer (PC) risk and aggressiveness. In Latino men, information on this association is scarce. Hence, the aim of this study was to evaluate this association in Mexican males. Using fragment analysis by capillary electrophoresis, we determined the number of CAG repeats-(CAG)n-in AR gene from 158 incident PC cases and 326 age-matched healthy controls (±5 years), residing in Mexico City, Mexico. According to Gleason scale and age at diagnosis, cases were classified as high (⩾7) and low grade (<7), as well as early onset (<60 years) or late onset PC (⩾60 years). At diagnosis, 78% of cases were classified as high-grade and 26.6% as early onset. Men with sporadic (no family history of PC) and early-onset PC presented shorter CAG repeat length than controls (18.6±2.2 vs 19.5±2.5; P=0.02). Lower number of CAG repeats (CAG)⩽19 were associated with a greater risk for early-onset PC (odds ratio: 2.31; 95% confidence interval: 1.14-4.69). CAG repeat length could increase the risk for sporadic and early-onset PC. The best cutoff point for identifying at-risk subjects was (CAG)19. However, further studies are necessary to replicate our findings in subjects with a family history of PC and also to evaluate the association between CAG repeats length and disease progression.
authors.affiliation: Departamento de Toxicología. Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Mexico DF, México.
authors.forename: Rocío
authors.initials: R
authors.lastname: Gómez
authors.affiliation: Instituto Nacional de Salud Pública, Centro de Investigación en Salud Poblacional, Cuernavaca, México.
authors.forename: Luisa
authors.initials: L
authors.lastname: Torres-Sánchez
authors.affiliation: Departamento de Toxicología. Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Mexico DF, México.
authors.forename: Rafael
authors.initials: R
authors.lastname: Camacho-Mejorado
authors.affiliation: Instituto Nacional de Salud Pública, Centro de Investigación en Enfermedades Infecciosas, Cuernavaca, México.
authors.forename: Ana I
authors.initials: AI
authors.lastname: Burguete-García
authors.affiliation: Instituto Nacional de Salud Pública, Centro de Investigación en Salud Poblacional, Cuernavaca, México.
authors.forename: Ruth Argelia
authors.initials: RA
authors.lastname: Vázquez-Salas
authors.affiliation: Instituto Nacional de Salud Pública, Centro de Investigación en Enfermedades Infecciosas, Cuernavaca, México.|Instituto Nacional de Rehabilitación 'Luis Guillermo Ibarra', Laboratorio de Líquido Sinovial, Mexico DF, México.
authors.forename: Gabriela A
authors.initials: GA
authors.lastname: Martínez-Nava
authors.affiliation: Laboratorio BIMODI (Biología Molecular Diagnóstica), Santiago de Querétaro, México.
authors.forename: Carla
authors.initials: C
authors.lastname: Santana
authors.affiliation: Laboratorio BIMODI (Biología Molecular Diagnóstica), Santiago de Querétaro, México.
authors.forename: Gino
authors.initials: G
authors.lastname: Noris
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D060787:Neoplasm Grading; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011159:Population Surveillance; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology; D011944:Receptors, Androgen / Q000235:genetics*; D012306:Risk; D019680:Trinucleotide Repeat Expansion; D018911:Trinucleotide Repeats
chemical_list: D011944:Receptors, Androgen