title: The effect of preoperative neutrophil, platelet and lymphocyte counts on local recurrence and survival in early-stage tongue cancer.
abstract: The aim of this study was to investigate the predictive value of preoperative neutrophil, platelet and lymphocyte counts in local recurrence and survival in the patients operated for early-stage squamous cell carcinoma (SCC) of the tongue. 57 patients who underwent surgery for early-stage (stage 1-2) SCC of the tongue were enrolled in the study. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and neutrophil × PLR value (N × PLR) were used as outcome measures. Local recurrence was detected in 11 (19.3 %) patients during follow-up period. Mortality was seen in 7 (12.3 %) patients. 37 (64.9 %) patients had stage 1 and 20 (35.1 %) patients had stage 2 tumor. NLR, PLR and N × PLR cutoff values were determined as 2.26, 146,855 and 689,912, respectively, by receiver operating characteristic analysis. The relationship between NLR, PLR, N × PLR and local recurrence was statistically significant according to these cutoff values (p values 0.021, 0.020, 0.017, respectively). We suggest that NLR, PLR and N × PLR may be used to predict local recurrence, while their use in overall and disease-free survival is limited. Further studies involving large patient groups are required.
authors.affiliation: Department of Otorhinolaryngology, Ege University, Bornova, Izmir, Turkey.
authors.forename: Kerem
authors.initials: K
authors.lastname: Ozturk
authors.affiliation: Department of Otorhinolaryngology, Ege University, Bornova, Izmir, Turkey.
authors.forename: N Serdar
authors.initials: NS
authors.lastname: Akyildiz
authors.affiliation: Department of Otorhinolaryngology, Ege University, Bornova, Izmir, Turkey. mustafauslu85@hotmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Uslu
authors.affiliation: Department of Otorhinolaryngology, Ege University, Bornova, Izmir, Turkey.
authors.forename: Sercan
authors.initials: S
authors.lastname: Gode
authors.affiliation: Department of Otorhinolaryngology, Ege University, Bornova, Izmir, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Uluoz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001772:Blood Cell Count; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000401:mortality / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology; D055815:Young Adult
keywords: Neutrophil to lymphocyte ratio; Oral tongue cancer; Platelet to lymphocyte ratio; Squamous cell carcinoma; Tongue carcinoma