title: The pharmacokinetics of factor VIII and factor IX: methodology, pitfalls and applications.
abstract: This article reviews the pharmacokinetics of exogenous factor VIII and factor IX in patients with haemophilia. It focuses on the methodology (and inherent pitfalls) of pharmacokinetic studies, then summarizes available pharmacokinetic data and finally discusses some applications of pharmacokinetics for optimization of prophylactic treatment of haemophilia and for comparison of coagulation factor concentrates.
authors.affiliation: Hospital Pharmacy and Department for Coagulation Disorders, Malmö University Hospital, Malmö, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Björkman
authors.affiliation: Hospital Pharmacy and Department for Coagulation Disorders, Malmö University Hospital, Malmö, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Carlsson
keywords: comparative studies; dosing; factor IX; factor VIII; methodological aspects; pharmacokinetics.