title: A Catalytic Peterson-like Synthesis of Alkenyl Nitriles.
abstract: A heterogeneous fluoride catalyst was found to enable the straightforward formation of alkenyl nitriles from the reaction of aldehydes and simple or substituted acetonitriles, in the presence of commercially available silazanes and in solvent-free conditions. The protocol afforded the products in good to excellent yields with selectivity values dependent on the nature of the substrates. It represents an alternative to classic approaches using stoichiometric strong bases, and the catalyst can be easily recovered and reused for consecutive cycles.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Perugia , Via del Liceo, 1 - 06123 Perugia, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Lanari
authors.affiliation: Laboratory of Green Synthetic Organic Chemistry, CEMIN - Dipartimento di Chimica, Biologia e Biotecnologie, Università di Perugia , Via Elce di Sotto, 8 - 06123 Perugia, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Alonzi
authors.affiliation: Laboratory of Green Synthetic Organic Chemistry, CEMIN - Dipartimento di Chimica, Biologia e Biotecnologie, Università di Perugia , Via Elce di Sotto, 8 - 06123 Perugia, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Ferlin
authors.affiliation: Laboratory of Green Synthetic Organic Chemistry, CEMIN - Dipartimento di Chimica, Biologia e Biotecnologie, Università di Perugia , Via Elce di Sotto, 8 - 06123 Perugia, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Santoro
authors.affiliation: Laboratory of Green Synthetic Organic Chemistry, CEMIN - Dipartimento di Chimica, Biologia e Biotecnologie, Università di Perugia , Via Elce di Sotto, 8 - 06123 Perugia, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Vaccaro