title: Overview of C3 Glomerulopathy.
abstract: C3 glomerulopathy is an umbrella term, which includes several rare forms of glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A common histological feature noted in all these GN is dominant C3 deposition in the glomerulus. In this review, we will provide an overview of the complement system as well as mediators, with an introduction to pharmaceutical agents that can alter the pathway.
authors.affiliation: University of Illinois College of Medicine , Peoria, IL , USA.
authors.forename: Vimal
authors.initials: V
authors.lastname: Master Sankar Raj
authors.affiliation: University of Illinois College of Medicine , Peoria, IL , USA.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gordillo
authors.affiliation: University of Illinois College of Medicine, Peoria, IL, USA; Associate Medical Director, Research and Development, Abbvie, Chicago, IL, USA.
authors.forename: Deepa H
authors.initials: DH
authors.lastname: Chand
keywords: C3 glomerulopathies; atypical HUS; children; complement C3; kidney disease