title: RECIST 1.1-Update and clarification: From the RECIST committee.
abstract: The Response Evaluation Criteria in Solid Tumours (RECIST) were developed and published in 2000, based on the original World Health Organisation guidelines first published in 1981. In 2009, revisions were made (RECIST 1.1) incorporating major changes, including a reduction in the number of lesions to be assessed, a new measurement method to classify lymph nodes as pathologic or normal, the clarification of the requirement to confirm a complete response or partial response and new methodologies for more appropriate measurement of disease progression. The purpose of this paper was to summarise the questions posed and the clarifications provided as an update to the 2009 publication.
authors.affiliation: Department of Radiology, Columbia University Medical Center, New York, NY, USA; New York Presbyterian Hospital, New York, NY, USA. Electronic address: LSchwartz@columbia.edu.
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Schwartz
authors.affiliation: EORTC HQ, Brussels, Belgium.
authors.forename: Saskia
authors.initials: S
authors.lastname: Litière
authors.affiliation: Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: de Vries
authors.affiliation: Clinical Trials Imaging Consulting, NJ, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Ford
authors.affiliation: Department of Medical Imaging, East Surrey Hospital, Redhill, Surrey, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: Gwyther
authors.affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
authors.forename: Sumithra
authors.initials: S
authors.lastname: Mandrekar
authors.affiliation: Clinical Trials Branch, Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, USA.
authors.forename: Lalitha
authors.initials: L
authors.lastname: Shankar
authors.affiliation: EORTC HQ, Brussels, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: Bogaerts
authors.affiliation: Early Clinical Trials Development Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, USA.
authors.forename: Alice
authors.initials: A
authors.lastname: Chen
authors.affiliation: Canadian Cancer Trials Group, Queen's University, Kingston, Canada.
authors.forename: Janet
authors.initials: J
authors.lastname: Dancey
authors.affiliation: Exploratory Clinical & Translational Research, Bristol-Myers Squibb, Princeton, NJ, USA.
authors.forename: Wendy
authors.initials: W
authors.lastname: Hayes
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: F Stephen
authors.initials: FS
authors.lastname: Hodi
authors.affiliation: Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Otto S
authors.initials: OS
authors.lastname: Hoekstra
authors.affiliation: National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
authors.forename: Erich P
authors.initials: EP
authors.lastname: Huang
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Nancy
authors.initials: N
authors.lastname: Lin
authors.affiliation: EORTC HQ, Brussels, Belgium.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Laboratoires Servier, Paris, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Therasse
authors.affiliation: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical and Graduate Colleges, New York, NY, USA; Ludwig Institute for Cancer Research, New York, NY, USA.
authors.forename: Jedd D
authors.initials: JD
authors.lastname: Wolchok
authors.affiliation: Canadian Cancer Trials Group, Queen's University, Kingston, Canada.
authors.forename: Lesley
authors.initials: L
authors.lastname: Seymour
mesh_terms: D026683:Advisory Committees; D018450:Disease Progression; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D066066:Response Evaluation Criteria in Solid Tumors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Clarifications; RECIST; Tumour response