title: MicroRNA 486-3P as a stability marker in acute coronary syndrome.
abstract: Easily accessible biomarkers are needed to diagnose cardiovascular disease precisely-particularly, to distinguish between disease subtypes that are encountered in clinical practice. Per the hypothesis that plasma miRNA is valuable for this purpose, we performed complete transcriptional profiling of an miRNA discovery-set in 14 samples: three patients with ST-elevated acute myocardial infarction (STEMI) at baseline and after three months of follow-up, four with stable ischaemic heart disease (stable-IHD) and four healthy age-matched volunteers. Our aim was to determine whether we could distinguish patients with unstable plaques from stable patients following a STEMI event. After analysing miRNA profiles, we conducted a validation study comparing three-month STEMI (n=40) with stable-IHD (n=35), which confirmed that miR-486-3P differentiates patients with three-month STEMI from those with stable-IHD (P=0.019).
authors.affiliation: Department of Dermatology, Bispebjerg Hospital, Bispebjerg, Denmark weitianling@gmail.com.
authors.forename: Tianling
authors.initials: T
authors.lastname: Wei
authors.affiliation: Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.
authors.forename: Lasse
authors.initials: L
authors.lastname: Folkersen
authors.affiliation: Atherosclerosis Research Unit, Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Ewa
authors.initials: E
authors.lastname: Ehrenborg
authors.affiliation: Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Gabrielsen
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000235:genetics / Q000473:pathology; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000235:genetics / Q000473:pathology; D012333:RNA, Messenger / Q000097:blood; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C560945:MIRN486 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger
keywords: coronary artery disease; diagnosis biomarker; microRNA