title: Using metabolomics to dissect host-parasite interactions.
abstract: Protozoan parasites have evolved diverse growth and metabolic strategies for surviving and proliferating within different extracellular and intracellular niches in their mammalian hosts. Metabolomic approaches, including high coverage metabolite profiling and (13)C/(2)H-stable isotope labeling, are increasingly being used to identify parasite metabolic pathways that are important for survival and replication in vivo. These approaches are highlighting new links between parasite carbon metabolism and the ability of different parasite stages to colonize specific niches or host cell types. They have also revealed novel metabolic regulatory mechanisms that are important for homeostasis and survival in potentially nutrient variable environments. These studies highlight the importance of parasite and host metabolism as determinants of host-parasite interactions.
authors.affiliation: Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Kloehn
authors.affiliation: Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Blume
authors.affiliation: Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: S A
authors.initials: SA
authors.lastname: Cobbold
authors.affiliation: Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: E C
authors.initials: EC
authors.lastname: Saunders
authors.affiliation: Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: M J
authors.initials: MJ
authors.lastname: Dagley
authors.affiliation: Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia. Electronic address: malcolmm@unimelb.edu.au.
authors.forename: M J
authors.initials: MJ
authors.lastname: McConville
mesh_terms: D000818:Animals; D006019:Glycolysis / Q000502:physiology; D058507:Host Specificity / Q000502:physiology; D006790:Host-Parasite Interactions / Q000502:physiology*; D007891:Leishmania / Q000378:metabolism*; D008018:Life Cycle Stages / Q000502:physiology; D053858:Metabolic Networks and Pathways; D055432:Metabolomics; D010963:Plasmodium falciparum / Q000378:metabolism*; D014122:Toxoplasma / Q000378:metabolism*; D014346:Trypanosoma brucei brucei / Q000378:metabolism*