title: Single dose intravenous dexmedetomidine prolongs spinal anesthesia with hyperbaric bupivacaine.
abstract: BACKGROUND
  Spinal block, a known technique to obtain anaesthesia for infraumblical surgeries. Now physician have advantage of using adjuvant to prolong the effect of intrathecal block, which can be given either intravenously or intrathecally, dexmedetomidine is one of them. We studied effect of intravenous dexmedetomidine for prolongation of duration of intrathecal block of 0.5% bupivacaine block.
  
  
  OBJECTIVE
  To evaluate the effect of intravenous dexmedetomidine on sensory regression, hemodynamic profile, level of sedation and postoperative analgesia.
  
  
  METHODS
  60 patients of ASA grade I and II posted for elective infraumblical surgeries were included in the study and randomly allocated into two groups. Group D recieved intrathecal 0.5% bupivacaine heavy, followed by infusion of intravenous dexmedetomidine 0.5mic/kg over 10 min, patients in group C received intrathecal 0.5% bupivacaine heavy 3ml followed by infusion of same volume of normal saline as placebo.
  
  
  RESULTS
  Two segment regression of sensory block was achieved at 139.0 ± 13.797 in group D whereas in group C it was only 96.67 ± 7.649min, the total duration of analgesia achieved in both study groups was 234.67 ± 7.649min and 164.17 ± 6.170min respectively in group D and group C. The time at which first analgesic was given to the patients when VAS >3 achieved that is in group D at 234.67 ± 7.649min and in group C at 164.17 ± 6.170min. Inj diclofenac sodium 75mg intramuscular was used as rescue analgesic.
authors.affiliation: Department of Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Kubre
authors.affiliation: Department of Anaesthesiology and Critical Care, N.S.C.B. Medical College, Jabalpur, Madhya Pradesh, India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Sethi
authors.affiliation: Department of Anaesthesiology and Critical Care, N.S.C.B. Medical College, Jabalpur, Madhya Pradesh, India.
authors.forename: Mamta
authors.initials: M
authors.lastname: Mahobia
authors.affiliation: Department of Anaesthesiology, S.M.S. Medical College, Jaipur, Rajasthan, India.
authors.forename: Deeksha
authors.initials: D
authors.lastname: Bindal
authors.affiliation: Department of Anaesthesiology and Critical Care, N.S.C.B. Medical College, Jabalpur, Madhya Pradesh, India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Narang
authors.affiliation: Department of Critical Care and Emergency Medicine, Sir Ganga Ram Hospital, New Delhi, India.
authors.forename: Anudeep
authors.initials: A
authors.lastname: Saxena
keywords: Intravenous dexmedetomidine; postoperative analgesia; sensory regression; spinal block