title: Lack of an Association between Neutrophil-to-Lymphocyte Ratio and PSA Failure of Prostate Cancer Patients Who Underwent Radical Prostatectomy.
abstract: Introduction. The neutrophil-to-lymphocyte ratio (NLR), which can be easily calculated from routine complete blood counts of the peripheral blood, has been suggested to serve as a prognostic factor for some solid malignancies. In the present study, we aimed to determine the relationship between NLR in prostate cancer patients undergoing radical prostatectomy (RP) and their prognosis. Materials and Methods. We assessed NLR in 73 men (patients) who received RP for their prostate cancer. We also performed immunohistochemistry for CD8 and CD66b in a separate set of RP specimens. Results. The median NLR in the 73 patients was 1.85. There were no significant correlations of NLR with tumor grade (p = 0.834), pathological T stage (p = 0.082), lymph node metastasis (p = 0.062), or resection margin status (p = 0.772). Based on the area under the receiver operator characteristic curve (AUROC) to predict biochemical recurrence after RP, potential NLR cut-off point was determined to be 2.88 or 3.88. However, both of these cut-off points did not precisely predict the prognosis. There were no statistically significant differences in the number of CD66b-positive neutrophils or CD8-positive lymphocytes between stromal tissues adjacent to cancer glands and stromal tissues away from cancer glands and between different grades or stages of tumors. Conclusions. There was no association between NLR and biochemical failure after prostatectomy.
authors.affiliation: Departments of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama 2320024, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Maeda
authors.affiliation: Departments of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama 2320024, Japan; Department of Urology, Yokohama City University, Graduate School of Medicine, Yokohama 2360004, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawahara
authors.affiliation: Departments of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama 2320024, Japan.
authors.forename: Mitsuyuki
authors.initials: M
authors.lastname: Koizumi
authors.affiliation: Departments of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama 2320024, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ito
authors.affiliation: Departments of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama 2320024, Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kumano
authors.affiliation: Departments of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama 2320024, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Ohtaka
authors.affiliation: Departments of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama 2320024, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Kondo
authors.affiliation: Departments of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama 2320024, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Mochizuki
authors.affiliation: Departments of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama 2320024, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hattori
authors.affiliation: Departments of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama 2320024, Japan.
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Teranishi
authors.affiliation: Departments of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama 2320024, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yumura
authors.affiliation: Departments of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama 2320024, Japan.
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Miyoshi
authors.affiliation: Department of Urology, Yokohama City University, Graduate School of Medicine, Yokohama 2360004, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yao
authors.affiliation: Departments of Pathology and Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyamoto
authors.affiliation: Departments of Urology and Renal Transportation, Yokohama City University Medical Center, Yokohama 2320024, Japan.
authors.forename: Hiroji
authors.initials: H
authors.lastname: Uemura
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001772:Blood Cell Count / Q000706:statistics & numerical data; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007962:Leukocytes / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D015995:Prevalence; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy / Q000706:statistics & numerical data*; D011471:Prostatic Neoplasms / Q000098:blood supply / Q000473:pathology* / Q000601:surgery*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen