title: Use of a platelet-rich fibrin membrane to repair traumatic tympanic membrane perforations: a comparative study.
abstract: OBJECTIVE
  (1) To evaluate the effects of a platelet-rich fibrin (PRF) membrane in the repair of traumatic tympanic membrane (TM) perforations; and (2) to compare the use of a PRF membrane with the paper patch technique with regard to recovery rates, healing time, and correction of the mean air-bone gap.
  
  
  METHODS
  A randomized, prospective analysis was performed for 60 patients who were treated for traumatic TM perforations using one of the two methods. Closure rate, speed of healing, and hearing gain were compared between the PRF (Group 1) and paper patch (Group 2) groups.
  
  
  RESULTS
  Closure was obtained in 28 (93%) perforations in Group 1 and 25 (83%) perforations in Group 2 (p > 0.05). On day 10, full closure of the TM was observed in 24 (80%) patients in Group 1 and 16 (53%) patients in Group 2 (p < 0.05). The improvement in the mean air-bone gap was 14.1 dB in Group 1 and 12.4 dB in Group 2 on post-operative day 45 (p < 0.05).
  
  
  CONCLUSIONS
  In comparison with the paper patch method, PRF, a new method, provided more rapid healing with more successful audiological results, and with no requirement for a second procedure.
authors.affiliation: a Department of ENT , Antalya Education and Research Hospital , Antalya , Turkey ;
authors.forename: Özer Erdem
authors.initials: ÖE
authors.lastname: Gür
authors.affiliation: a Department of ENT , Antalya Education and Research Hospital , Antalya , Turkey ;
authors.forename: Nuray
authors.initials: N
authors.lastname: Ensari
authors.affiliation: a Department of ENT , Antalya Education and Research Hospital , Antalya , Turkey ;
authors.forename: Mehmet Türker
authors.initials: MT
authors.lastname: Öztürk
authors.affiliation: b Department of ENT , Antalya Medical Park Hospital , Antalya , Turkey ;
authors.forename: Osman Fatih
authors.initials: OF
authors.lastname: Boztepe
authors.affiliation: c Department of ENT , Bahçeşehir University, Faculty of Medicine, Medical Park Hospital , Ankara , Turkey.
authors.forename: Taylan
authors.initials: T
authors.lastname: Gün
authors.affiliation: a Department of ENT , Antalya Education and Research Hospital , Antalya , Turkey ;
authors.forename: Ömer Tarık
authors.initials: ÖT
authors.lastname: Selçuk
authors.affiliation: a Department of ENT , Antalya Education and Research Hospital , Antalya , Turkey ;
authors.forename: Levent
authors.initials: L
authors.lastname: Renda
mesh_terms: D000328:Adult; D001299:Audiometry; D001792:Blood Platelets; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D011446:Prospective Studies; D018058:Tympanic Membrane Perforation / Q000628:therapy*
chemical_list: D008567:Membranes, Artificial; D005337:Fibrin
keywords: Wound healing; ear drum perforation; fibrin membrane; thrombocyte concentrates