title: Imidazo[1,2-a]Pyridine-3-Carboxamides Are Active Antimicrobial Agents against Mycobacterium avium Infection In Vivo.
abstract: A panel of six imidazo[1,2-a]pyridine-3-carboxamides (IAPs) were shown to have low-micromolar activity against Mycobacterium avium strains. Compound ND-10885 (compound 2) showed significant activity in the lung, spleen, and liver in a mouse M. avium infection model. A combined regimen consisting of ND-10885 (compound 2) and rifampin was additive in its anti-M. avium activity in the lung. Our data indicate that IAPs represent a new class of antibiotics that are active against M. avium and could potentially serve as an effective addition to a combined treatment regimen.
authors.affiliation: Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana, USA.
authors.forename: Garrett C
authors.initials: GC
authors.lastname: Moraski
authors.affiliation: Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA.
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Cho
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA.
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Cramer
authors.affiliation: Discovery Chemistry, Eli Lilly and Company, Indianapolis, Indiana, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Godfrey
authors.affiliation: Discovery Chemistry, Eli Lilly and Company, Indianapolis, Indiana, USA.
authors.forename: Thierry
authors.initials: T
authors.lastname: Masquelin
authors.affiliation: Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA.
authors.forename: Scott G
authors.initials: SG
authors.lastname: Franzblau
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
authors.forename: Marvin J
authors.initials: MJ
authors.lastname: Miller
authors.affiliation: Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA schorey.1@nd.edu.
authors.forename: Jeffery
authors.initials: J
authors.lastname: Schorey
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D051379:Mice; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects* / Q000472:pathogenicity*; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy* / Q000382:microbiology; D011725:Pyridines / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D007093:Imidazoles; D011725:Pyridines; C023666:pyridine