title: An Eigen-Binding Site Based Method for the Analysis of Anti-EGFR Drug Resistance in Lung Cancer Treatment.
abstract: We explore the drug resistance mechanism in non-small cell lung cancer treatment by characterizing the drug-binding site of a protein mutant based on local surface and energy features. These features are transformed to an eigen-binding site space and used for drug resistance level prediction and analysis.
authors.forename: Lichun
authors.initials: L
authors.lastname: Ma
authors.forename: Debby D
authors.initials: DD
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Zou
authors.forename: Hong
authors.initials: H
authors.lastname: Yan
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000378:metabolism / Q000627:therapeutic use; D001665:Binding Sites / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D056004:Molecular Dynamics Simulation; D009154:Mutation / Q000235:genetics; D011485:Protein Binding / Q000235:genetics; D047428:Protein Kinase Inhibitors / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D066246:ErbB Receptors