title: Synthesis and anti-proliferative activity of fluoro-substituted chalcones.
abstract: A series of novel fluoro-substituted chalcone derivatives have been synthesized. All synthesized compounds were characterized by (1)H nuclear magnetic resonance (NMR), (13)C NMR, and elemental analysis. Their anti-proliferative activities were evaluated against five cancer cells lines, namely, A549, A498, HeLa, A375, and HepG2 using the MTT method. Most of the compounds showed moderate to high activity with IC50 values in the range of 0.029-0.729μM. Of all the synthesized compounds, 10 and 19 exhibited the most potent anti-proliferative activities against cancer cells, and 10 was identified as the most promising compound.
authors.affiliation: Tercan Vocational High School, Erzincan University, Erzincan 24800, Turkey; Department of Chemistry, Faculty of Science, Ataturk University, Erzurum 25240, Turkey. Electronic address: sburmaoglu@erzincan.edu.tr.
authors.forename: Serdar
authors.initials: S
authors.lastname: Burmaoglu
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mersin University, Mersin 33169, Turkey. Electronic address: oztekinalgul@mersin.edu.tr.
authors.forename: Oztekin
authors.initials: O
authors.lastname: Algul
authors.affiliation: Department of Chemistry, Faculty of Science, Ataturk University, Erzurum 25240, Turkey.
authors.forename: Derya Aktas
authors.initials: DA
authors.lastname: Anıl
authors.affiliation: Department of Chemistry, Faculty of Science, Ataturk University, Erzurum 25240, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Gobek
authors.affiliation: Department of Medical Biology, Medical Faculty, Mustafa Kemal University, Antakya-Hatay 31100, Turkey.
authors.forename: Gulay Gulbol
authors.initials: GG
authors.lastname: Duran
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mersin University, Mersin 33169, Turkey.
authors.forename: Ronak Haj
authors.initials: RH
authors.lastname: Ersan
authors.affiliation: Department of Medical Microbiology, Medical Faculty, Mustafa Kemal University, Antakya-Hatay 31100, Turkey.
authors.forename: Nizami
authors.initials: N
authors.lastname: Duran
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002599:Chalcone / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002599:Chalcone
keywords: Anti-proliferative activity; Chalcone; Claisen–Schmidt condensation; Organofluorine; Synthesis