title: An Intracranial Electroencephalography (iEEG) Brain Function Mapping Tool with an Application to Epilepsy Surgery Evaluation.
abstract: OBJECTIVE
  Before epilepsy surgeries, intracranial electroencephalography (iEEG) is often employed in function mapping and epileptogenic foci localization. Although the implanted electrodes provide crucial information for epileptogenic zone resection, a convenient clinical tool for electrode position registration and Brain Function Mapping (BFM) visualization is still lacking. In this study, we developed a BFM Tool, which facilitates electrode position registration and BFM visualization, with an application to epilepsy surgeries.
  
  
  METHODS
  The BFM Tool mainly utilizes electrode location registration and function mapping based on pre-defined brain models from other software. In addition, the electrode node and mapping properties, such as the node size/color, edge color/thickness, mapping method, can be adjusted easily using the setting panel. Moreover, users may manually import/export location and connectivity data to generate figures for further application. The role of this software is demonstrated by a clinical study of language area localization.
  
  
  RESULTS
  The BFM Tool helps clinical doctors and researchers visualize implanted electrodes and brain functions in an easy, quick and flexible manner.
  
  
  CONCLUSIONS
  Our tool provides convenient electrode registration, easy brain function visualization, and has good performance. It is clinical-oriented and is easy to deploy and use. The BFM tool is suitable for epilepsy and other clinical iEEG applications.
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal UniversityBeijing, China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal UniversityBeijing, China.
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Electrical and Control Engineering, North China University of Technology Beijing, China.
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal UniversityBeijing, China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal UniversityBeijing, China.
authors.forename: Jianbin
authors.initials: J
authors.lastname: Wen
authors.affiliation: Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal UniversityBeijing, China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal UniversityBeijing, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Li
keywords: data visualization; electrode registration; epilepsy; function mapping; intracranial EEG