title: Relation between Liver Transaminases and Dyslipidaemia among 2-10 y.o. Northern Mexican Children.
abstract: The increase in overweight and obese children may be linked to increased rates of liver damage and dyslipidaemia. This study aimed to explore the associations of liver biomarkers with overweight/obesity and dyslipidaemia in Mexican children.
  
  
  
  The study was a population-based cross-sectional nutritional survey carried out in the State of Nuevo León, Mexico. The study included a 414 subjects aged between 2 and 10 years old (47.8% girls) who took part in the State Survey of Nutrition and Health-Nuevo León 2011/2012. Associations between alanine aminotransferase (ALT) and aspartate aminotransferase (AST), ALT/AST ratio, and major components of serum lipid profile were assessed.
  
  
  
  Children with high ALT (defined as ≥P75) showed higher prevalence of dyslipidaemia than their counterparts, with high prevalence of high TChol (P = 0.053), non-HDL-chol, TG, and low HDL-chol. Children with an AST/ALT ≥T3 ratio were 0.43-times (95% CI: 0.25-0.74) and 0.27-times (95% CI: 0.17-0.44) low likely to be overweight/obese and to have dyslipidaemia than those with an AST/ALT <T1 ratio, respectively. The risk of high TChol, LDL-chol, non-HDL-chol and TG, and low HDL-chol levels also decreased in AST/ALT ratio groups.
  
  
  
  Our results pose the need for further investigation on whether AST/ALT may be useful as screening test in the assessment of children with cardiometabolic risk.
authors.affiliation: Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, E-07122, Palma de Mallorca, Spain.|CIBEROBN (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, E-28029, Madrid, Spain.
authors.forename: Maria Del Mar
authors.initials: Mdel M
authors.lastname: Bibiloni
authors.affiliation: Faculty of Public Health Nutrition, Autonomous University of Nuevo León, 64460, Monterrey, Mexico.
authors.forename: Rogelio
authors.initials: R
authors.lastname: Salas
authors.affiliation: Faculty of Public Health Nutrition, Autonomous University of Nuevo León, 64460, Monterrey, Mexico.
authors.forename: Georgina M
authors.initials: GM
authors.lastname: Nuñez
authors.affiliation: Department of Health of the State of Nuevo León, 64000, Monterrey, Mexico.
authors.forename: Jesús Z
authors.initials: JZ
authors.lastname: Villarreal
authors.affiliation: Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, E-07122, Palma de Mallorca, Spain.|CIBEROBN (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, E-28029, Madrid, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Sureda
authors.affiliation: Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, E-07122, Palma de Mallorca, Spain.|CIBEROBN (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, E-28029, Madrid, Spain.
authors.forename: Josep A
authors.identifier: 0000-0002-6940-0761
authors.initials: JA
authors.lastname: Tur
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood / Q000201:enzymology* / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008800:Mexico; D009765:Obesity / Q000201:enzymology / Q000378:metabolism; D050177:Overweight / Q000201:enzymology / Q000378:metabolism
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase