title: Fabrication and characterization of SrAl2O4: Eu(2+)Dy(3+)/CS-PCL electrospun nanocomposite scaffold for retinal tissue regeneration.
abstract: Millions of people around the world become blind due to losing a part of the retina cells. In tissue engineering field one way to address this issue is to develop a retina tissue by scaffolds based on structure and signals received These scaffolds can play an essential role in repair and reformation of the damaged retina tissue. Here, SrAl2O4: Eu(2+), Dy(3+) nanophosphor were prepared by sol-gel method and then coated with PEG to become biocompatible. Next 10%, 30% and 50% concentration of the coated nanophosphors were dispersed in CS-PCL copolymer and electrospuned to form SrAl2O4: Eu(2+), Dy(3+)/CS-PCL scaffolds. The aforementioned photo -luminescence-scaffolds were studied for their optical, mechanical and morphological characteristics finally the effect of these scaffolds on the mice RPCs cells' proliferation and differentiation was observed. The 30% nanophosphor dispersion scaffold while providing adequate mechanical flexibility and integrity, and exhibiting superior proliferation rates and acceptable differentiation into retinal neural cells (particularly photo receptors retinal) is suggested as a promising choice in retinal tissue repair.
authors.affiliation: Department of Biomedical Engineering, Amirkabir University of Technology (AUT), Tehran, Iran.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Sepahvandi
authors.affiliation: Department of Biomedical Engineering, Amirkabir University of Technology (AUT), Tehran, Iran. Electronic address: eskandarim@aut.ac.ir.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Eskandari
authors.affiliation: Department of Biomedical Engineering, Amirkabir University of Technology (AUT), Tehran, Iran.
authors.forename: Fathollah
authors.initials: F
authors.lastname: Moztarzadeh
mesh_terms: D017607:Aluminum Compounds / Q000138:chemical synthesis / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D048271:Chitosan / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D051379:Mice; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D020419:Photoreceptor Cells, Vertebrate / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D012038:Regeneration / Q000187:drug effects; D012160:Retina / Q000502:physiology*; D013324:Strontium / Q000737:chemistry; D013718:Tensile Strength; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D017607:Aluminum Compounds; D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone; D048271:Chitosan; D013324:Strontium
keywords: Electrospinning; Nanophosphor; Photoluminescence; Retina; Scaffold