title: Ischemic postconditioning protects against ischemic brain injury by up-regulation of acid-sensing ion channel 2a.
abstract: Ischemic postconditioning renders brain tissue tolerant to brain ischemia, thereby alleviating ischemic brain injury. However, the exact mechanism of action is still unclear. In this study, a rat model of global brain ischemia was subjected to ischemic postconditioning treatment using the vessel occlusion method. After 2 hours of ischemia, the bilateral common carotid arteries were blocked immediately for 10 seconds and then perfused for 10 seconds. This procedure was repeated six times. Ischemic postconditioning was found to mitigate hippocampal CA1 neuronal damage in rats with brain ischemia, and up-regulate acid-sensing ion channel 2a expression at the mRNA and protein level. These findings suggest that ischemic postconditioning up-regulates acid-sensing ion channel 2a expression in the rat hippocampus after global brain ischemia, which promotes neuronal tolerance to ischemic brain injury.
authors.affiliation: Department of Neurosurgery, General Hospital of Tibet Military Area Command, Lasa, China.
authors.forename: Wang-Sheng
authors.initials: WS
authors.lastname: Duanmu
authors.affiliation: Department of Neurosurgery, Southwest Hospital of Third Military Medical University, Chongqing, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Neurosurgery, Southwest Hospital of Third Military Medical University, Chongqing, China.
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Southwest Hospital of Third Military Medical University, Chongqing, China.
authors.forename: Hong-Fei
authors.initials: HF
authors.lastname: Ge
authors.affiliation: Department of Neurosurgery, Southwest Hospital of Third Military Medical University, Chongqing, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Hu
authors.affiliation: Department of Neurosurgery, Southwest Hospital of Third Military Medical University, Chongqing, China.
authors.forename: Hua
authors.identifier: 0000-0002-3605-7354
authors.initials: H
authors.lastname: Feng
keywords: acid-sensing ion channels; brain injury; gene expression; ischemic brain injury; ischemic postconditioning; ischemic tolerance; molecular mechanism; nerve regeneration; neural regeneration; neuronal density; neuroprotection; protein expression