title: Post-transcriptional Regulation of Immunological Responses through Riboclustering.
abstract: Immunological programing of immune cells varies in response to changing environmental signals. This process is facilitated by modifiers that regulate the translational fate of mRNAs encoding various immune mediators, including cytokines and chemokines, which in turn determine the rapid activation, tolerance, and plasticity of the immune system. RNA-binding proteins (RBPs) recruited by the specific sequence elements in mRNA transcripts are one such modifiers. These RBPs form RBP-RNA complexes known as "riboclusters." These riboclusters serve as RNA sorting machinery, where depending upon the composition of the ribocluster, translation, degradation, or storage of mRNA is controlled. Recent findings suggest that this regulation of mRNA homeostasis is critical for controlling the immune response. Here, we present the current knowledge of the ribocluster-mediated post-transcriptional regulation of immune mediators and highlight recent findings regarding their implications for the pathogenesis of acute or chronic inflammatory diseases.
authors.affiliation: Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad , Hyderabad , India.
authors.forename: Koelina
authors.initials: K
authors.lastname: Ganguly
authors.affiliation: Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad , Hyderabad , India.
authors.forename: Jeevan
authors.initials: J
authors.lastname: Giddaluru
authors.affiliation: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University , New York, NY , USA.
authors.forename: Avery
authors.initials: A
authors.lastname: August
authors.affiliation: Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad , Hyderabad , India.
authors.forename: Nooruddin
authors.initials: N
authors.lastname: Khan
keywords: T cell maturation; inflammation; mRNA stability; polysomes; stress granules; thymic and peripheral tolerance