title: Immunoisolation to prevent tissue graft rejection: Current knowledge and future use.
abstract: This review focuses on the concept of immunoisolation and how this method has evolved over the last few decades. The concept of immunoisolation came out of the need to protect allogeneic transplant tissue from the host immune system and avoid systemic side effects of immunosuppression. The latter remains a significant hurdle in clinical translation of using tissue transplants for restoring endocrine function in diabetes, growth hormone deficiency, and other conditions. Herein, we review the most significant works studying the use of hydrogels, specifically alginate and poly (ethylene glycol), and membranes for immunoisolation and discuss how this approach can be applied in reproductive biology.
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Anu
authors.initials: A
authors.lastname: David
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: James
authors.initials: J
authors.lastname: Day
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA shikanov@umich.edu.
authors.forename: Ariella
authors.initials: A
authors.lastname: Shikanov
mesh_terms: D000464:Alginates; D000818:Animals; D003921:Diabetes Mellitus, Experimental; D020723:Glucuronic Acid; D006084:Graft Rejection / Q000276:immunology*; D006603:Hexuronic Acids; D006801:Humans; D020100:Hydrogels; D051379:Mice; D014184:Transplantation, Homologous / Q000295:instrumentation / Q000379:methods*
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D020100:Hydrogels; D020723:Glucuronic Acid
keywords: Immunoisolation; TheraCyte; alginate; poly (ethylene glycol); premature ovarian failure