title: Increased Intracranial Pressure in a Boy with Gorham-Stout Disease.
abstract: Gorham-Stout disease (GSD), also known as vanishing bone disease, is a rare disorder, which most commonly presents in children and young adults and is characterized by an excessive proliferation of lymphangiomatous tissue within the bones. This lymphangiomatous proliferation often affects the cranium and, due to the proximate location to the dura surrounding cerebrospinal fluid (CSF) spaces, can result in CSF leaks manifesting as intracranial hypotension with clinical symptoms to include orthostatic headache, nausea, and vertigo. We present the case of a boy with GSD and a known history of migraine headaches who presented with persistent headaches due to increased intracranial pressure. Although migraine had initially been suspected, he was eventually diagnosed with intracranial hypertension after developing ophthalmoplegia and papilledema. We describe the first known instance of successful medical treatment of increased intracranial pressure in a patient with GSD.
authors.affiliation: Departments of Pediatrics, San Antonio Military Medical Center, JBSA, Fort Sam Houston, Tex., USA.
authors.forename: Manisha K
authors.initials: MK
authors.lastname: Patel
authors.affiliation: Departments of Ophthalmology, San Antonio Military Medical Center, JBSA, Fort Sam Houston, Tex., USA.
authors.forename: Brent R
authors.initials: BR
authors.lastname: Mittelstaedt
authors.affiliation: Departments of Ophthalmology, San Antonio Military Medical Center, JBSA, Fort Sam Houston, Tex., USA.
authors.forename: Frank E
authors.initials: FE
authors.lastname: Valentin
authors.affiliation: Departments of Radiology, San Antonio Military Medical Center, JBSA, Fort Sam Houston, Tex., USA.
authors.forename: Linda P
authors.initials: LP
authors.lastname: Thomas
authors.affiliation: Departments of Radiology, San Antonio Military Medical Center, JBSA, Fort Sam Houston, Tex., USA.
authors.forename: Christian L
authors.initials: CL
authors.lastname: Carlson
authors.affiliation: Departments of Pediatrics, San Antonio Military Medical Center, JBSA, Fort Sam Houston, Tex., USA; Division of Pediatric Neurology, San Antonio Military Medical Center, JBSA, Fort Sam Houston, Tex., USA.
authors.forename: Brian M
authors.initials: BM
authors.lastname: Faux
authors.affiliation: Departments of Pediatrics, San Antonio Military Medical Center, JBSA, Fort Sam Houston, Tex., USA; Division of Pediatric Neurology, San Antonio Military Medical Center, JBSA, Fort Sam Houston, Tex., USA.
authors.forename: David T
authors.initials: DT
authors.lastname: Hsieh
keywords: Gorham-Stout disease; Headache; Intracranial hypertension; Migraine