title: Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application.
abstract: The aim of this study was to construct redox- and pH-responsive degradable manganese dioxide (MnO2) nanosheets for cancer theranostic application. The small MnO2 nanosheets were synthesized, and then functionalized by hyaluronic acid (HA), demonstrating excellent stability and tumor-targeting ability. Cisplatin (cis-diamminedichloroplatinum [CDDP]) was absorbed by the nanosheets through a physical action, which was designed as MnO2/HA/CDDP. The prepared MnO2/HA/CDDP formulation was able to efficiently deliver CDDP to tumor cells in vitro and in vivo, resulting in improved therapeutic efficiency. Subsequently, they were triggered by lower pH and higher level of reduced glutathione to generate Mn(2+), enabling magnetic resonance imaging. The smart multifunctional system combining efficient magnetic resonance imaging and chemotherapy has the potential to be used as a tumor-targeting theranostic nanomedicine.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Hao
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China; School of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Bingxiang
authors.initials: B
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Dong
authors.initials: D
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Dehui
authors.initials: D
authors.lastname: Meng
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Shi
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Hongling
authors.initials: H
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000072283:A549 Cells; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D002945:Cisplatin / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D004705:Endocytosis / Q000187:drug effects; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D042541:Intracellular Space / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D017895:Manganese Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy*; D010084:Oxidation-Reduction; D010087:Oxides / Q000138:chemical synthesis / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D017895:Manganese Compounds; D010087:Oxides; D006820:Hyaluronic Acid; D002945:Cisplatin; C016552:manganese dioxide
keywords: hyaluronic acid; magnetic resonance imaging; manganese dioxide nanosheets; theranostic application