title: The Clinical Significance of the Insulin-Like Growth Factor-1 Receptor Polymorphism in Non-Small-Cell Lung Cancer with Epidermal Growth Factor Receptor Mutation.
abstract: The insulin-like growth factor 1 (IGF1) signaling pathway mediates multiple cancer cell biological processes. IGF1 receptor (IGF1R) expression has been used as a reporter of the clinical significance of non-small-cell lung carcinoma (NSCLC). However, the association between IGF1R genetic variants and the clinical utility of NSCLC positive for epidermal growth factor receptor (EGFR) mutation is not clear. The current study investigated the association between the IGF1R genetic variants, the occurrence of EGFR mutations, and clinicopathological characteristics in NSCLC patients. A total of 452 participants, including 362 adenocarcinoma lung cancer and 90 squamous cell carcinoma lung cancer patients, were selected for analysis of IGF1R genetic variants (rs7166348, rs2229765, and rs8038415) using real-time polymerase chain reaction (PCR)genotyping. The results indicated that GA + AA genotypes of IGF1R rs2229765 were significantly associated with EGFR mutation in female lung adenocarcinoma patients (odds ratio (OR) = 0.39, 95% confidence interval (CI) = 0.17-0.87). Moreover, The GA + AA genotype IGF1R rs2229765 was significantly associated with EGFR L858R mutation (p = 0.02) but not with the exon 19 in-frame deletion. Furthermore, among patients without EGFR mutation, those who have at least one polymorphic A allele of IGF1R rs7166348 have an increased incidence of lymph node metastasis when compared with those patients homozygous for GG (OR, 2.75; 95% CI, 1.20-2.31). Our results showed that IGF1R genetic variants are related to EGFR mutation in female lung adenocarcinoma patients and may be a predictive factor for tumor lymph node metastasis in Taiwanese patients with NSCLC.
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. liou.dj@msa.hinet.net.|Department of Chest Medicine, Cheng-Ching General Hospital, Taichung 402, Taiwan. liou.dj@msa.hinet.net.
authors.forename: Tu-Chen
authors.initials: TC
authors.lastname: Liu
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. 170780@cch.org.tw.|Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan. 170780@cch.org.tw.
authors.forename: Ming-Ju
authors.initials: MJ
authors.lastname: Hsieh
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA. oldyei@gmail.com.
authors.forename: Ming-Che
authors.initials: MC
authors.lastname: Liu
authors.affiliation: School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan. wlchiang@csmu.edu.tw.
authors.forename: Whei-Ling
authors.initials: WL
authors.lastname: Chiang
authors.affiliation: School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. his885889@gmail.com.|Division of Chest, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan. his885889@gmail.com.
authors.forename: Thomas Chang-Yao
authors.initials: TC
authors.lastname: Tsao
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. ysf@csmu.edu.tw.|Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan. ysf@csmu.edu.tw.
authors.forename: Shun-Fa
authors.initials: SF
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D017526:Receptor, IGF Type 1; D017451:Receptors, Somatomedin / Q000235:genetics*; D017384:Sequence Deletion; D012727:Sex Characteristics; D013624:Taiwan
chemical_list: C000597236:IGF1R protein, human; D017451:Receptors, Somatomedin; C512478:EGFR protein, human; D066246:ErbB Receptors; D017526:Receptor, IGF Type 1
keywords: epidermal growth factor receptor; genetic variants; insulin-like growth factor 1 receptor; non-small-cell lung carcinoma