title: Low-Level Laser for Mitigation of Low Salivary Flow Rate in Head and Neck Cancer Patients Undergoing Radiochemotherapy: A Prospective Longitudinal Study.
abstract: OBJECTIVE
  The present study aimed to assess the impact of low-level laser (LLL) on low salivary flow rate in patients undergoing radiochemotherapy (RT-CT) for head and neck cancer.
  
  
  BACKGROUND
  LLL has shown efficiency in preventing hyposalivation in patients under different pathological conditions, including those undergoing RT-CT.
  
  
  METHODS
  During all RT-CT, 17 patients received laser therapy and 10 received clinical care only. An Indium-Gallium-Aluminum-Phosphorus diode laser was punctually used for intraoral (660 nm, 40 mW, 10 J/cm(2), illuminated area 0.04 cm(2), 10 sec) and extraoral irradiation (780 nm, 15 mW, 3.8 J/cm(2), illuminated area 0.04 cm(2), 10 sec), three times a week and on alternate days, for a total of 21 sessions. Unstimulated salivary flow rate was assessed before the first RT session (N0), at the 15th RT session (N15), at the last RT session (Nf), and at 30 (N30) and 90 days after the end of the oncologic treatment (N90).
  
  
  RESULTS
  At N15, Nf, and N30, patients treated with LLL showed significantly higher averages of salivary flow rate when compared with patients receiving clinical care only.
  
  
  CONCLUSIONS
  LLL seems to be an efficient tool for mitigation of salivary hypofunction in patients undergoing RT for head and neck cancer.
authors.affiliation: Division of Radiotherapy, Department of Imaging Diagnosis, Universidade Federal de São Paulo/Escola Paulista de Medicina/Hospital São Paulo - UNIFESP/EPM/HSP , São Paulo/SP, Brazil .
authors.forename: Fernanda Aurora Stabile
authors.initials: FA
authors.lastname: Gonnelli
authors.affiliation: Division of Radiotherapy, Department of Imaging Diagnosis, Universidade Federal de São Paulo/Escola Paulista de Medicina/Hospital São Paulo - UNIFESP/EPM/HSP , São Paulo/SP, Brazil .
authors.forename: Luiz Felipe
authors.initials: LF
authors.lastname: Palma
authors.affiliation: Division of Radiotherapy, Department of Imaging Diagnosis, Universidade Federal de São Paulo/Escola Paulista de Medicina/Hospital São Paulo - UNIFESP/EPM/HSP , São Paulo/SP, Brazil .
authors.forename: Adelmo José
authors.initials: AJ
authors.lastname: Giordani
authors.affiliation: Division of Radiotherapy, Department of Imaging Diagnosis, Universidade Federal de São Paulo/Escola Paulista de Medicina/Hospital São Paulo - UNIFESP/EPM/HSP , São Paulo/SP, Brazil .
authors.forename: Aline Lima Silva
authors.initials: AL
authors.lastname: Deboni
authors.affiliation: Division of Radiotherapy, Department of Imaging Diagnosis, Universidade Federal de São Paulo/Escola Paulista de Medicina/Hospital São Paulo - UNIFESP/EPM/HSP , São Paulo/SP, Brazil .
authors.forename: Rodrigo Souza
authors.initials: RS
authors.lastname: Dias
authors.affiliation: Division of Radiotherapy, Department of Imaging Diagnosis, Universidade Federal de São Paulo/Escola Paulista de Medicina/Hospital São Paulo - UNIFESP/EPM/HSP , São Paulo/SP, Brazil .
authors.forename: Roberto Araújo
authors.initials: RA
authors.lastname: Segreto
authors.affiliation: Division of Radiotherapy, Department of Imaging Diagnosis, Universidade Federal de São Paulo/Escola Paulista de Medicina/Hospital São Paulo - UNIFESP/EPM/HSP , São Paulo/SP, Brazil .
authors.forename: Helena Regina Comodo
authors.initials: HR
authors.lastname: Segreto
mesh_terms: D000328:Adult; D000368:Aged; D059248:Chemoradiotherapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000628:therapy*; D006801:Humans; D054023:Lasers, Semiconductor; D008137:Longitudinal Studies; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D014987:Xerostomia / Q000209:etiology* / Q000532:radiotherapy*