title: Measuring the Hydrodynamic Size of Nanoparticles Using Fluctuation Correlation Spectroscopy.
abstract: Fluctuation correlation spectroscopy (FCS) is a well-established analytical technique traditionally used to monitor molecular diffusion in dilute solutions, the dynamics of chemical reactions, and molecular processes inside living cells. In this review, we present the recent use of FCS for measuring the size of colloidal nanoparticles in solution. We review the theoretical basis and experimental implementation of this technique and its advantages and limitations. In particular, we show examples of the use of FCS to measure the size of gold nanoparticles, monitor the rotational dynamics of gold nanorods, and investigate the formation of protein coronas on nanoparticles.
authors.affiliation: Department of Chemistry, Rice University, Houston, Texas 77005; email: slink@rice.edu.
authors.forename: Sergio
authors.initials: S
authors.lastname: Dominguez-Medina
authors.affiliation: Department of Chemistry, Rice University, Houston, Texas 77005; email: slink@rice.edu.
authors.forename: Sishan
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Rice University, Houston, Texas 77005; email: slink@rice.edu.
authors.forename: Jan
authors.initials: J
authors.lastname: Blankenburg
authors.affiliation: Department of Chemistry, Rice University, Houston, Texas 77005; email: slink@rice.edu.
authors.forename: Pattanawit
authors.initials: P
authors.lastname: Swanglap
authors.affiliation: Department of Chemistry, Rice University, Houston, Texas 77005; email: slink@rice.edu.|Department of Electrical and Computer Engineering, Rice University, Houston, Texas 77005.|Laboratory for Nanophotonics, Rice University, Houston, Texas 77005.|Smalley-Curl Institute, Rice University, Houston, Texas 77005.
authors.forename: Christy F
authors.initials: CF
authors.lastname: Landes
authors.affiliation: Department of Chemistry, Rice University, Houston, Texas 77005; email: slink@rice.edu.|Department of Electrical and Computer Engineering, Rice University, Houston, Texas 77005.|Laboratory for Nanophotonics, Rice University, Houston, Texas 77005.|Smalley-Curl Institute, Rice University, Houston, Texas 77005.
authors.forename: Stephan
authors.initials: S
authors.lastname: Link
keywords: colloids; nanobio interactions; nanoparticle characterization; translational and rotational diffusion