title: Non-genomic oestrogen receptor signal in B lymphocytes: An approach towards therapeutic interventions for infection, autoimmunity and cancer.
abstract: The non-genomic membrane bound oestrogen receptor (mER) regulates intracellular signals through receptor-ligand interactions. The mER, along with G-protein coupled oestrogen receptor GPR 30 (GPER), induces diverse cell signalling pathways in murine lymphocytes. The mER isoform ER-alpha46 has recently been demonstrated in human B and T lymphocytes as an analogue receptor for chemokine CCL18, the signalling events of which are not clearly understood. Ligand-induced mER and GPER signalling events are shared with BCR, CD19 mediated intracellular signalling through phospholipase C, PIP2/IP3/PI3 mediated activation of Akt, MAP kinase, and mTOR. Oestrogen has the ability to induce CD40-mediated activation of B cells. The complete signalling pathways of mER, GPR30 and their interaction with other signals are targeted areas for novel drug development in B cells during infection, autoimmunity and cancer. Therefore, an in depth investigation is critical for determining shared signal outputs during B cell activation. Here, we focus on the mode of action of membrane bound ER in B cells as therapeutic checkpoints.
authors.affiliation: Microbiology, Immunology, Saint James School of Medicine, Albert Lake Drive, The Quarter, AI-2640, P.O. Box 318, British West Indies, Anguilla.
authors.forename: Karsen
authors.initials: K
authors.lastname: Seto
authors.affiliation: Microbiology, Immunology, Saint James School of Medicine, Albert Lake Drive, The Quarter, AI-2640, P.O. Box 318, British West Indies, Anguilla.
authors.forename: Minh
authors.initials: M
authors.lastname: Hoang
authors.affiliation: Microbiology, Immunology, Saint James School of Medicine, Albert Lake Drive, The Quarter, AI-2640, P.O. Box 318, British West Indies, Anguilla.
authors.forename: Thaddeus
authors.initials: T
authors.lastname: Santos
authors.affiliation: Biological Sciences, Trident Technical College, North Charleston, SC, USA.
authors.forename: Mausumi
authors.initials: M
authors.lastname: Bandyopadhyay
authors.affiliation: Cell Biology, Medical University of South Carolina, Charleston, SC, USA; Molecular Pharmacology and Physiology, University of South Florida, Tampa, USA.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Kindy
authors.affiliation: Microbiology, Immunology, Saint James School of Medicine, Albert Lake Drive, The Quarter, AI-2640, P.O. Box 318, British West Indies, Anguilla; Biochemistry, Saint James School of Medicine, Albert Lake Drive, The Quarter, AI-2640, P.O. Box 318, British West Indies, Anguilla. Electronic address: sdasgupta@mail.sjsm.org.
authors.forename: Subhajit
authors.initials: S
authors.lastname: Dasgupta
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D019742:Chemokines, CC / Q000235:genetics / Q000276:immunology; D047628:Estrogen Receptor alpha / Q000235:genetics / Q000276:immunology; D004967:Estrogens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007239:Infections / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D051379:Mice; D009363:Neoplasm Proteins / Q000235:genetics / Q000276:immunology*; D009369:Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D011960:Receptors, Estrogen / Q000235:genetics / Q000276:immunology*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*
chemical_list: C111792:CCL18 protein, human; D019742:Chemokines, CC; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D004967:Estrogens; C109584:GPER1 protein, human; D009363:Neoplasm Proteins; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled
keywords: B lymphocytes; Cytoplasmic signalling pathway; Membrane receptor; Non-genomic signal; Oestrogen receptor