title: Polycystic Ovary Syndrome in Adolescents.
abstract: Polycystic ovary syndrome (PCOS) is a familial heterogeneous disorder affecting 6% to 10% of reproductive-age women. The use of criteria developed for adult women is problematic for the adolescent girl because the clinical features associated with PCOS are normal pubertal events. The recent consensus statement on PCOS in adolescents stated that hyperandrogenism and oligomenorrhea need to persist for at least 2 years to consider the diagnosis of PCOS. Although insulin resistance, hyperinsulinism, and obesity are often associated with PCOS, these features are not considered valid diagnostic criteria. Recent genomewide association studies implicate genetic loci involved in the hypothalamic-pituitary-ovarian axis.
authors.affiliation: Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.
authors.forename: Selma Feldman
authors.initials: SF
authors.lastname: Witchel
authors.affiliation: Division of Pediatric Endocrinology, Diabetes & Metabolism, Columbia University Medical Center, 622 West 168th Street, PH5E-522, New York, NY 10032, USA.
authors.forename: Hailey
authors.initials: H
authors.lastname: Roumimper
authors.affiliation: Columbia University Medical Center, Columbia University, 622 West 168th Street, PH5E-522, New York, NY 10032, USA. Electronic address: seo8@columbia.edu.
authors.forename: Sharon
authors.initials: S
authors.lastname: Oberfield
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications*; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications; D009839:Oligomenorrhea / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*
keywords: Adolescent; Hyperandrogenism; Irregular menses; Metabolic syndrome; Polycystic ovary syndrome