title: Identification and analytical characterization of four synthetic cannabinoids ADB-BICA, NNL-1, NNL-2, and PPA(N)-2201.
abstract: Since the first appearance as psychotropic drugs in illegal markets in 2008, the spread of synthetic cannabinoids is becoming a serious problem in many countries. This paper reports on the analytical properties and structure elucidation of four cannabimimetic derivatives in seized material: 1-benzyl-N-(1-carbamoyl-2,2-dimethylpropan-1-yl)-1H-indole-3-carboxamide (ADB-BICA, 1), N-(1-carbamoylpropan-1-yl)-1-(5-fluoropentyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide (NNL-1, 2), (4-benzylpiperazin-1-yl)(1-(5-fluoropentyl)-1H-indol-3-yl)methanone (NNL-2, 3), and N-(1-carbamoyl-2-phenylethyl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide (PPA(N)-2201, 4). The identifications were based on liquid chromatography-quadrupole-time-of-flight-mass spectrometry (LC-QTOF-MS), gas chromatography-mass spectrometry (GC-MS), Fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance (NMR) spectroscopy. No chemical or pharmacological data about compounds 1-3 have appeared until now, making this the first report on these compounds. The GC-MS data of 4 has been reported, but this study added the LC-MS, FT-IR, and NMR data for additional characterization. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Qian
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Hua
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Cuimei
authors.initials: C
authors.lastname: Liu
mesh_terms: D002186:Cannabinoids / Q000032:analysis*; D002853:Chromatography, Liquid / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D013287:Illicit Drugs / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods; D011619:Psychotropic Drugs / Q000032:analysis*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods
chemical_list: D002186:Cannabinoids; D013287:Illicit Drugs; D011619:Psychotropic Drugs
keywords: ADB-BICA; NNL-1; NNL-2; PPA(N)-2201; new psychoactive substance; synthetic cannabinoids