title: The Hamster Buccal Pouch Model of Oral Carcinogenesis.
abstract: The hamster buccal pouch (HBP) carcinogenesis model is one of the most well-characterized animal tumor models used as a prelude to investigate multistage oral carcinogenesis and to assess the efficacy of chemointervention. Hamster buccal pouch carcinomas induced by 7,12-dimethylbenz[a]anthracene (DMBA) show extensive similarities to human oral squamous cell carcinomas. The HBP model offers a number of advantages including a simple and predictable tumor induction procedure, easy accessibility for examination and follow-up of lesions, and reproducibility. This model can be used to test both chemopreventive and chemotherapeutic agents.
authors.affiliation: Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India. s_nagini@yahoo.com.
authors.forename: Siddavaram
authors.initials: S
authors.lastname: Nagini
authors.affiliation: Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India.
authors.forename: Jaganathan
authors.initials: J
authors.lastname: Kowshik
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced*; D006224:Cricetinae; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000139:chemically induced*; D015203:Reproducibility of Results
chemical_list: D015127:9,10-Dimethyl-1,2-benzanthracene
keywords: Carcinogenesis; Chemointervention; DMBA; Hamster; Oral cancer