title: Schizophrenia as a mimic of behavioral variant frontotemporal dementia.
abstract: Recently, the diagnostic criteria for the behavioral variant of frontotemporal dementia were revised. Although these criteria offer a relatively high sensitivity, their specificity is yet unknown. We describe a 54-year-old woman fulfilling criteria for both late-onset schizophrenia and probable behavioral variant frontotemporal dementia. Following an initial presentation with psychosis, she developed progressive apathy, compulsiveness, and executive dysfunction. Moreover, bilateral frontotemporal hypometabolism was seen on [(18)F]fludeoxyglucose-positron emission tomography. A post-mortem diagnosis of schizophrenia was established, given the clinical picture combined with the pathological exclusion of a neurodegenerative cause. Our case suggests that patients with other brain disorders may meet the current diagnostic criteria for probable frontotemporal dementia. Further clinicopathological validation of these criteria is needed to determine their exact specificity.
authors.affiliation: a Department of Old Age Psychiatry , GGZ InGeest , Amsterdam , The Netherlands.
authors.forename: Cora J
authors.initials: CJ
authors.lastname: Kerssens
authors.affiliation: b Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam , VU University Medical Center , Amsterdam , the Netherlands.
authors.forename: Welmoed A
authors.initials: WA
authors.lastname: Krudop
authors.affiliation: c Alzheimer Center, Neuroscience Campus Amsterdam , VU University Medical Center , Amsterdam , the Netherlands.
authors.forename: Niels D
authors.initials: ND
authors.lastname: Prins
authors.affiliation: d Department of Nuclear medicine and PET Research, Neuroscience Campus Amsterdam , VU University Medical Center , Amsterdam , the Netherlands.
authors.forename: Bart N M
authors.initials: BN
authors.lastname: van Berckel
authors.affiliation: e Department of Neuropathology, Neuroscience Campus Amsterdam , VU University Medical Center , Amsterdam , the Netherlands.
authors.forename: Annemieke
authors.initials: A
authors.lastname: Rozemuller
authors.affiliation: f Memory and Aging Center, Departments of Neurology and Pathology , University of California , San Francisco , CA , USA.
authors.forename: William W
authors.initials: WW
authors.lastname: Seeley
authors.affiliation: b Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam , VU University Medical Center , Amsterdam , the Netherlands.
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.affiliation: a Department of Old Age Psychiatry , GGZ InGeest , Amsterdam , The Netherlands.
authors.forename: Max L
authors.initials: ML
authors.lastname: Stek
authors.affiliation: b Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam , VU University Medical Center , Amsterdam , the Netherlands.
authors.forename: Yolande A L
authors.initials: YA
authors.lastname: Pijnenburg
mesh_terms: D003933:Diagnosis; D003937:Diagnosis, Differential; D005260:Female; D057180:Frontotemporal Dementia / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D012559:Schizophrenia / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology
keywords: FTDC criteria; Frontotemporal dementia; imaging; neuropathology; schizophrenia