title: Physical and emotional well-being of survivors of childhood and young adult allo-SCT - A Danish national cohort study.
abstract: The aim of this investigation was to examine, within a population-based study of a national cohort comprising Danish survivors of allo-SCT (n = 148), the long-term effects of allo-SCT in children and young adults. Physical and emotional well-being was assessed using the Short Form 36 (SF-36) and the HADS. Allo-SCT-related data were obtained from the participants' medical records. The study includes 148 patients, with an 89% response rate (n = 132). For comparison purposes, norm data from Danish (1994, n = 6000), Swedish (2006, n = 285), and British (2001, n = 1792) population samples were used. Factors negatively influencing the SF-36 subscales included female gender; TBI; stem cells derived from PB; older age at time of questioning; and living alone. Factors significantly (p < 0.05) influencing HADS were transplantation with stem cells derived from PB and being underweight at time of questioning (median values were within normal range). Overall scores of allo-SCT patients were similar to norm data. In conclusion, this national cohort study shows that patients treated with SCT in early life (<25) and whose survival period extended beyond 10 yr (mean) from SCT, showed similar levels of anxiety, depression, and physical and emotional well-being to those of the normal population.
authors.affiliation: Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Josef Nathan
authors.initials: JN
authors.lastname: Jensen
authors.affiliation: Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Frederik
authors.initials: F
authors.lastname: Gøtzsche
authors.affiliation: Department of Pediatrics and Adolescent Medicine, BMT unit 4072, University Hospital of Copenhagen, Copenhagen, Denmark.
authors.forename: Carsten
authors.initials: C
authors.lastname: Heilmann
authors.affiliation: Department of Hematology, University Hospital of Copenhagen, Copenhagen, Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Sengeløv
authors.affiliation: The University Hospitals Center for Nursing and Care Research (UCSF), Department 7331, University Hospital of Copenhagen, Copenhagen, Denmark.
authors.forename: Lis
authors.initials: L
authors.lastname: Adamsen
authors.affiliation: Department of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Karl Bang
authors.initials: KB
authors.lastname: Christensen
authors.affiliation: Department of Pediatrics and Adolescent Medicine, University Hospital of Copenhagen, Copenhagen, Denmark.
authors.forename: Hanne Baekgaard
authors.initials: HB
authors.lastname: Larsen
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003718:Denmark / Q000453:epidemiology; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006305:Health Status Indicators; D018380:Hematopoietic Stem Cell Transplantation / Q000523:psychology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008603:Mental Health; D011788:Quality of Life / Q000523:psychology; D017741:Survivors / Q000523:psychology; D014184:Transplantation, Homologous; D055815:Young Adult
keywords: adolescents; depression; graft-vs.-host disease; hematopoietic stem cell transplantation; pediatric; quality-of-life