title: A Fast Strategy for Determination of Vitamin B₉ in Food and Pharmaceutical Samples Using an Ionic Liquid-Modified Nanostructure Voltammetric Sensor.
abstract: Vitamin B₉ or folic acid is an important food supplement with wide clinical applications. Due to its importance and its side effects in pregnant women, fast determination of this vitamin is very important. In this study we present a new fast and sensitive voltammetric sensor for the analysis of trace levels of vitamin B₉ using a carbon paste electrode (CPE) modified with 1,3-dipropylimidazolium bromide (1,3-DIBr) as a binder and ZnO/CNTs nanocomposite as a mediator. The electro-oxidation signal of vitamin B₉ at the surface of the 1,3-DIBr/ZnO/CNTs/CPE electrode appeared at 800 mV, which was about 95 mV less positive compared to the corresponding unmodified CPE. The oxidation current of vitamin B₉ by square wave voltammetry (SWV) increased linearly with its concentration in the range of 0.08-650 μM. The detection limit for vitamin B₉ was 0.05 μM. Finally, the utility of the new 1,3-DIBr/ZnO/CNTs/CPE electrode was tested in the determination of vitamin B₉ in food and pharmaceutical samples.
authors.affiliation: The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari 4815733971, Iran. khaleghi.ft@gmail.com.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Khaleghi
authors.affiliation: Young Researchers and Elite Club, Ayatollah Amoli Branch, Islamic Azad University, Mazandaran 46351-43358, Iran. ab.elyasi.ir@gmail.com.
authors.forename: Abolfazl Elyasi
authors.initials: AE
authors.lastname: Irai
authors.affiliation: Department of Physics, Science and Research Branch, Islamic Azad University, Mazandaran 1477893855, Iran. r00sadeghi@gmail.com.
authors.forename: Roya
authors.initials: R
authors.lastname: Sadeghi
authors.affiliation: Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India. vinodfcy@iitr.ac.in.|Department of Applied Chemistry, University of Johannesburg, Johannesburg 3204/6, South Africa. vinodfcy@iitr.ac.in.
authors.forename: Vinod Kumar
authors.initials: VK
authors.lastname: Gupta
authors.affiliation: Key Laboratory of Applied Chemistry, Jiangxi Agricultural University, Nanchang 330045, China. wenyangping1980@gmail.com.
authors.forename: Yangping
authors.initials: Y
authors.lastname: Wen
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D055664:Electrochemical Techniques; D004566:Electrodes; D005492:Folic Acid / Q000032:analysis* / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D057230:Limit of Detection; D049329:Nanostructures / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry; D015034:Zinc Oxide / Q000737:chemistry
chemical_list: D052578:Ionic Liquids; D037742:Nanotubes, Carbon; D005492:Folic Acid; D015034:Zinc Oxide
keywords: ZnO/CNTs; ionic liquids; modified electrode; vitamin B9