title: Recent Progress in Aptamer-Based Functional Probes for Bioanalysis and Biomedicine.
abstract: Nucleic acid aptamers are short synthetic DNA or RNA sequences that can bind to a wide range of targets with high affinity and specificity. In recent years, aptamers have attracted increasing research interest due to their unique features of high binding affinity and specificity, small size, excellent chemical stability, easy chemical synthesis, facile modification, and minimal immunogenicity. These properties make aptamers ideal recognition ligands for bioanalysis, disease diagnosis, and cancer therapy. This review highlights the recent progress in aptamer selection and the latest applications of aptamer-based functional probes in the fields of bioanalysis and biomedicine.
authors.affiliation: College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
authors.forename: Leiji
authors.initials: L
authors.lastname: Zhou
authors.affiliation: College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China. cyyang@xmu.edu.cn.
authors.forename: Chaoyong
authors.identifier: http://orcid.org/0000-0002-2374-5342
authors.initials: C
authors.lastname: Yang
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D008024:Ligands
chemical_list: D052157:Aptamers, Nucleotide; D008024:Ligands
keywords: SELEX; aptamers; biosensors; nanotheranostics; nucleic acids; targeting