title: A Multidisciplinary Assessment of Remote Myocardial Fibrosis After Reperfused Myocardial Infarction in Swine and Patients.
abstract: In extensive nonreperfused myocardial infarction (MI), remote fibrosis has been documented. Early reperfusion by primary angioplasty represents the gold standard method to minimize the extension of the infarction. We aimed to ascertain whether fibrosis also affects remote regions in reperfused MI in swine and patients. Swine were subjected to a transient occlusion of the left anterior descending artery followed by 1-week or 1-month reperfusion. Collagen content in the remote area macroscopically, microscopically, by magnetic resonance microimaging, and at the molecular level was similar to controls. In patients with previous MI, samples from autopsies displayed a significant increase in collagen content only in the infarct region. In patients with previous MI submitted to cardiac magnetic resonance-T1 mapping, the extracellular volume fraction in remote segments was similar to that for controls. In all scenarios, the remote region did not show a significant increase of collagen content in comparison with controls.
authors.affiliation: Cardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
authors.forename: Arantxa
authors.initials: A
authors.lastname: Hervas
authors.affiliation: Pathology Department, School of Medicine, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain. amparo.ruiz-sauri@uv.es.
authors.forename: Amparo
authors.initials: A
authors.lastname: Ruiz-Sauri
authors.affiliation: Cardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Gavara
authors.affiliation: ERESA, Valencia, Spain.
authors.forename: Jose V
authors.initials: JV
authors.lastname: Monmeneu
authors.affiliation: Cardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: de Dios
authors.affiliation: Cardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
authors.forename: Cesar
authors.initials: C
authors.lastname: Rios-Navarro
authors.affiliation: Cardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
authors.forename: Nerea
authors.initials: N
authors.lastname: Perez-Sole
authors.affiliation: CBIT, Polytechnic University of Valencia, Valencia, Spain.
authors.forename: Itziar
authors.initials: I
authors.lastname: Perez
authors.affiliation: Laboratory of Metabolomics, University of Valencia, INCLIVA, Valencia, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Monleon
authors.affiliation: Laboratory of Metabolomics, University of Valencia, INCLIVA, Valencia, Spain.|UCIM, University of Valencia, Valencia, Spain.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Morales
authors.affiliation: Cardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
authors.forename: Gema
authors.initials: G
authors.lastname: Minana
authors.affiliation: Cardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
authors.forename: Julio
authors.initials: J
authors.lastname: Nunez
authors.affiliation: Cardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
authors.forename: Clara
authors.initials: C
authors.lastname: Bonanad
authors.affiliation: SCSIE, Universidad de Valencia, Valencia, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Diaz
authors.affiliation: Physiology Department, School of Medicine, University of Valencia, Valencia, Spain.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Vila
authors.affiliation: Cardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Chorro
authors.affiliation: Cardiology Department, Hospital Clinico Universitario, INCLIVA, University of Valencia, Blasco Ibanez 17, 46010, Valencia, Spain. vicente.bodi@uv.es.
authors.forename: Vicente
authors.initials: V
authors.lastname: Bodi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001344:Autopsy; D016022:Case-Control Studies; D003094:Collagen / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005355:Fibrosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D058628:Myofibroblasts / Q000378:metabolism / Q000473:pathology; D062645:Percutaneous Coronary Intervention; D034421:Sus scrofa; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D003094:Collagen
keywords: Myocardial infarction; Remote fibrosis; Reperfusion; Swine model