title: Benefits and medium-term outcome of the Sorin Pericarbon Freedom stentless aortic prosthesis in cases of acute bacterial endocarditis.
abstract: The aim of this study is to evaluate the ease of use and the advantages of Sorin Pericarbon Freedom (SPF) stentless valve in cases of acute bacterial endocarditis and to check the intermediate-term results after the implant of SPF with respect to resistance to infection, valve deterioration and durability.
  
  
  
  Between June 2003 and February 2015, 26 patients with active aortic valve bacterial endocarditis underwent aortic valve replacement with SPF pericardial stentless aortic prosthesis. The mean age was 57 ± 18 years; 73% of the patients were in preoperative NYHA class III and VI. Mean Logistic EuroSCORE was 14.2 ± 12.7. Endocarditis occurred in 18 patients with native valves, and in 9 patients with prosthetic valves (4 mechanical aortic valve prostheses; 5 aortic bioprostheses). Aortic root abscesses were observed in 16 cases (61.5%). Surgery was emergent in 3 cases (11.5%). Redo surgery was performed in 9 cases (35%). Cumulative follow-up was 126.8 patient-years (mean 4.9 ± 3.3 years).
  
  
  
  Operative hospital mortality was 0% for all patients. Residual mean prosthetic gradient at discharge was 9.4 ± 3.6 mmHg. Neither residual aortic incompetence nor residual abscess cavity was observed at discharge. Mean ejection fraction at discharge was 54 ± 8% (Min; Max: 35%; 65%). A total of 4 patients died at follow-up, all for non-cardiac causes. One patient was lost to follow-up. Two patients (8%) underwent non-valve-related reoperation with 0% mortality. Residual mean gradient at follow-up was 7.2 ± 2.1 mmHg. Three patients (17%) presented with mild/moderate aortic incompetence and 89% of patients were in NYHA Class I-II at follow-up. At 9 years, actuarial freedom from valve-related reoperation and from structural valve deterioration was 100%.
  
  
  
  The SPF aortic prosthesis is a true pericardial stentless prosthesis suitable for the treatment of acute bacterial endocarditis. Intermediate-time results in terms of freedom from reoperation, structural valve deterioration and resistance to infections are satisfactory. Haemodynamic performances are excellent since a complete exclusion of aortic root abscesses is achieved without any reduction of the aortic annular diameter, usually due to marsupialization or patch closure of the infected cavities.
authors.affiliation: Department of Cardiac Surgery, Cardiology and Anesthesiology Hesperia Hospital, Modena, Italy guglielmostefanelli@gmail.com stefanelli.guglielmo@gmail.com.
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Stefanelli
authors.affiliation: Department of Cardiac Surgery, Cardiology and Anesthesiology Hesperia Hospital, Modena, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Pirro
authors.affiliation: Department of Cardiac Surgery, Cardiology and Anesthesiology Hesperia Hospital, Modena, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Meli
authors.affiliation: Department of Cardiac Surgery, Cardiology and Anesthesiology Hesperia Hospital, Modena, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Trevisan
authors.affiliation: Department of Cardiac Surgery, Cardiology and Anesthesiology Hesperia Hospital, Modena, Italy.
authors.forename: Mariassunta
authors.initials: M
authors.lastname: Telesca
authors.affiliation: Department of Cardiac Surgery, Cardiology and Anesthesiology Hesperia Hospital, Modena, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Campisano
authors.affiliation: Department of Infectious Diseases, University Hospitals, Modena, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Mussini
authors.affiliation: Department of Cardiology, University Hospitals, Modena, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Barbieri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001021:Aortic Valve / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D001705:Bioprosthesis; D002417:Cattle; D004697:Endocarditis, Bacterial / Q000150:complications / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D012086:Reoperation; D055815:Young Adult
keywords: Acute bacterial endocarditis; Aortic valve replacement; Stentless aortic valve prosthesis