title: To not be hot when TRPV1 is not.
abstract: Induction of hyperthermia emerged as a major side effect impeding the development of antagonists of the transient receptor potential vanilloid-1 (TRPV1) nociceptor. New ligands are now exploiting the complicated pharmacology of TRPV1 to avoid hyperthermia while insights continue to grow regarding the mechanistic basis for the action of TRPV1 ligands on thermoregulation.
authors.affiliation: Laboratory of Cancer Biology and Genetics; Center for Cancer Research; National Cancer Institute ; Bethesda, MD, USA.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Blumberg
keywords: TRPV1; TRPV1, transient receptor potential vanilloid-1; antagonist; capsaicin; drug development; pain; thermoregulation; vanilloid