title: Management of unilocular or multilocular cysts more than 5 centimeters in postmenopausal women.
abstract: OBJECTIVE
  To evaluate the malignancy potential of large unilocular and multilocular ovarian cysts in postmenopausal women and to discuss their appropriate management.
  
  
  METHODS
  This retrospective study included 204 postmenopausal patients who underwent surgery for simple adnexal cysts or cysts with isolated septal structures at the Gynecology and Obstetrics Clinic of Bakirkoy Dr Sadi Konuk Training and Research Hospital. Data obtained from patient and computer records included patient age, follow-up period, ultrasonography reports, surgery information, histopathological evaluation results, and cancer antigen-125 (CA-125) levels at diagnosis and during follow-up. The Kruskal-Wallis test was used to compare three or more groups. The Chi-square test or Fisher's exact test was used to compare qualitative parameters, while relationships between parameters were analyzed by using Spearman's correlation analysis.
  
  
  RESULTS
  A total of 236 cysts were identified in 204 postmenopausal women who underwent surgery. The cysts were categorized as having unilocular cyst morphology or complex structures without morphological abnormalities other than septa in 182 (77.1%) and 54 cases (22.9%), respectively. The mean cyst diameter was 6.6±3.1cm (range, 2.7-30cm) with diameters ≥5cm in 176 cysts (75%). The median cyst volume was 88.5 cm(3) (range, 10-2636; interquartile range: 81) and the mean morphology index was 1.2 (range, 1-6), with 16 cysts (6.8%) ≥5. No malignancy or borderline histology was observed in any patient.
  
  
  CONCLUSIONS
  Among postmenopausal women, cysts that are unilocular or contain isolated septa, have a low-risk of malignancy even when they are larger than 5cm. Rather than undergoing emergency surgery, these patients may be followed up conservatively with intermittent transvaginal ultrasonography.
authors.affiliation: Department of Obstetrics and Gynecology, Bakirkoy Dr Sadi Konuk Teaching and Research Hospital, Istanbul, Turkey. Electronic address: guraslanhakan@gmail.com.
authors.forename: Hakan
authors.initials: H
authors.lastname: Guraslan
authors.affiliation: Department of Obstetrics and Gynecology, Bakirkoy Dr Sadi Konuk Teaching and Research Hospital, Istanbul, Turkey.
authors.forename: Keziban
authors.initials: K
authors.lastname: Dogan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018394:CA-125 Antigen; D003537:Cystadenoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D010048:Ovarian Cysts / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D017698:Postmenopause; D012189:Retrospective Studies; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D018394:CA-125 Antigen
keywords: Histopathology; Ovarian cyst; Postmenopause; Ultrasonography