title: Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits.
abstract: Carbon monoxide poisoning is one of the important emergency situations manifested by primarily acute and chronic anoxic central nervous system (CNS) injuries and other organ damages. Current descriptions and therapeutic approaches have been focused on the anoxic pathophysiology. However, this point of view incompletely explains some of the outcomes and needs to be investigated extensively. Considering this, we propose that reactive oxygen species (ROS) including especially nitric oxide (NO) are likely to be a key concept to understand the emergency related to CO poisoning and to discover new therapeutic modalities in CO toxicity. If we consider the hypothesis that ROS is involved greatly in acute and chronic toxic effects of CO on CNS and some other vital organs such as heart, it follows that the antioxidant and anti-NO therapies might give the clinicians more opportunities to prevent deep CNS injury. In support of this, we review the subject in essence and summarize clinical and experimental studies that support a key role of ROS in the explanation of pathophysiology of CO toxicity as well as new treatment modalities after CO poisoning.
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey. Electronic address: sumeyyaak@gmail.com.
authors.forename: Sumeyya
authors.initials: S
authors.lastname: Akyol
authors.affiliation: Department of Child Development, School of Health, Turgut Ozal University, Ankara, Turkey.
authors.forename: Sevda
authors.initials: S
authors.lastname: Yuksel
authors.affiliation: Ankara Regional Office of Council of Forensic Medicine, Morgue Department, Ankara, Turkey.
authors.forename: Sultan
authors.initials: S
authors.lastname: Pehlivan
authors.affiliation: Department of Biochemistry Laboratory, Corum Training and Research Hospital, Corum, Turkey.
authors.forename: Haci Kemal
authors.initials: HK
authors.lastname: Erdemli
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Gulec
authors.affiliation: Department of Biochemistry & Molecular Medicine, University of California, Davis, California, United States.
authors.forename: Bahattin
authors.initials: B
authors.lastname: Adam
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Akyol
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry*; D001921:Brain / Q000378:metabolism; D002248:Carbon Monoxide / Q000737:chemistry; D002249:Carbon Monoxide Poisoning / Q000517:prevention & control*; D002490:Central Nervous System / Q000293:injuries*; D006801:Humans; D019271:Hypoxanthine / Q000737:chemistry; D000860:Hypoxia; D017551:Microdialysis; D008962:Models, Theoretical; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D051381:Rats; D017382:Reactive Oxygen Species / Q000737:chemistry; D015427:Reperfusion Injury; D013481:Superoxides / Q000737:chemistry; D014527:Uric Acid / Q000737:chemistry; D014969:Xanthine Oxidase / Q000737:chemistry
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D013481:Superoxides; D014527:Uric Acid; D019271:Hypoxanthine; D009569:Nitric Oxide; D002248:Carbon Monoxide; D014969:Xanthine Oxidase; D010100:Oxygen
keywords: Anoxia; Antioxidant therapy; Carbon monoxide poisoning; Injury; Nitric oxide; Reactive oxygen species