title: Commentary: Mitochondrial DNA damage and loss in diabetes.
abstract: This commentary discusses damage and loss of mitochondrial DNA (mtDNA) in type 2 diabetes mellitus from both the clinical and experimental perspectives. Increasingly, an array of studies in experimental models and patients suggests that the cellular stresses of insulin resistance in type 2 diabetes damage mtDNA, leading to loss of mitochondrial genetic content. As such, mtDNA is emerging as both a valuable monitoring tool and translational preventive target for metabolic disease. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Departments of Biology, The University of Texas Rio Grande Valley, Edinburg, TX, USA. robert.gilkerson@utrgv.edu.|Clinical Laboratory Sciences, The University of Texas Rio Grande Valley, Edinburg, TX, USA. robert.gilkerson@utrgv.edu.
authors.forename: Robert
authors.initials: R
authors.lastname: Gilkerson
mesh_terms: D004249:DNA Damage; D004272:DNA, Mitochondrial / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000473:pathology*; D006801:Humans
chemical_list: D004272:DNA, Mitochondrial