title: Cardiovascular Risk in Growth Hormone Deficiency: Beneficial Effects of Growth Hormone Replacement Therapy.
abstract: Growth hormone deficiency (GHD) in adulthood is associated with an increased risk of developing adverse cardiovascular events and with reduced life expectancy. Cardiovascular and metabolic abnormalities have so far been evaluated only in a small number of children with GHD and adolescents. In this article we review these abnormalities and their underlying mechanisms and discuss the beneficial effect of growth hormone treatment in subjects with GHD.
authors.affiliation: Pediatric Endocrine Unit, Hospital de Clinicas Caracas, Avenida Panteon, San Bernardino, Caracas, Venezuela. Electronic address: lanesroberto@gmail.com.
authors.forename: Roberto
authors.initials: R
authors.lastname: Lanes
mesh_terms: D000293:Adolescent; D002318:Cardiovascular Diseases / Q000150:complications*; D002319:Cardiovascular System / Q000503:physiopathology; D002648:Child; D020249:Hormone Replacement Therapy; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D008659:Metabolic Diseases / Q000150:complications; D012307:Risk Factors
chemical_list: D019382:Human Growth Hormone
keywords: Cardiac mass and function; Cardiovascular risk; Carotid intima-media thickness; Endothelial dysfunction; Growth hormone deficiency; Lipoprotein abnormalities; Vascular reactivity; Visceral adiposity