title: Deep brain stimulation for the treatment of hyperkinetic movement disorders.
abstract: Deep brain stimulation effectiveness is well recognized for different movement disorders including Parkinson's disease, dystonia and essential tremor, however several other diseases in this field may benefit from the technique although experience is sparse and evidences of benefit and risks are not established.
  
  
  
  In this review, we explored available evidence for effectiveness and safety of DBS in selected hyperkinetic movement disorders, including tardive dyskinesia, Huntington's disease, neuroacanthocytosis, myoclonus-dystonia, Tourette syndrome, orthostatic and Holmes' tremor. Expert commentary: The data referenced and discussed showed potential effectiveness for DBS in these disabling and refractory diseases. On the other hand, these disorders are quite complex and multifaceted, often composed of different movement disorders, as well as other motor and non-motor symptoms. Therefore, the possible contribution of DBS in improving patients' quality of life should be weighted in a strictly individual basis, keeping in mind the progressive nature of most of these disorders, as well as risk/benefit ratio.
authors.affiliation: a Neurology Unit , Campus Bio-Medico University of Rome , Rome , Italy.|b Nuffield Department of Clinical Neurosciences , University of Oxford , Oxford , UK.|c Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology , University of Oxford , Oxford , UK.|d Sobell Department of Motor Neuroscience and Movement Disorders, Unit of Functional Neurosurgery , University College London , London , UK.
authors.forename: Lazzaro
authors.initials: L
authors.lastname: di Biase
authors.affiliation: e Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital , University Health Network , Toronto , Canada.
authors.forename: Renato Puppi
authors.initials: RP
authors.lastname: Munhoz
mesh_terms: D046690:Deep Brain Stimulation; D020821:Dystonic Disorders; D006801:Humans; D006948:Hyperkinesis; D009069:Movement Disorders / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D011788:Quality of Life
keywords: Deep brain stimulation; Huntington’s disease; Tourette syndrome and orthostatic tremor; hyperkinetic movement disorders; myoclonus-dystonia syndrome; neuroacanthocytosis; tardive dyskinesia