title: Formation of C(sp(3) )-C(sp(3) ) Bonds through Nickel-Catalyzed Decarboxylative Olefin Hydroalkylation Reactions.
abstract: Olefins and carboxylic acids are among the most important feedstock compounds. They are commonly found in natural products and drug molecules. We report a new reaction of nickel-catalyzed decarboxylative olefin hydroalkylation, which provides a novel practical strategy for the construction of C(sp(3) )-C(sp(3) ) bonds. This reaction can tolerate a variety of synthetically relevant functional groups and shows good chemo- and regioselectivity. It enables cross-coupling of complex organic molecules containing olefin groups and carboxylic acid groups in a convergent fashion.
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale, iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, University of Science and Technology of China, Hefei, 230026, China.|Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Lu
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale, iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Xiao
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing, 100084, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale, iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, University of Science and Technology of China, Hefei, 230026, China. fuyao@ustc.edu.cn.
authors.forename: Yao
authors.initials: Y
authors.lastname: Fu
keywords: C−C bond formation; catalysis; decarboxylative cross-coupling; nickel; olefin hydroalkylation