title: Lnc-CC3 increases metastasis in cervical cancer by increasing Slug expression.
abstract: Although screening has reduced mortality rates, metastasis still results in poor survival and prognosis in cervical cancer patients. We compared cervical cancer ESTs libraries with other ESTs libraries to identify candidate genes and cloned a novel cervical cancer-associated lncRNA, lnc-CC3. Overexpression of lnc-CC3 promoted migration and invasion by SiHa cervical cancer cells in vitro and in vivo, increased Slug expression, and reduced the expression of the epithelial cell marker E-cadherin. Conversely, lnc-CC3 knockdown altered SiHa cell morphology and increased the expression of E-cadherin, thereby suppressing migration and invasion. These results suggest lnc-CC3 may be a useful marker of metastasis in cervical cancer.
authors.affiliation: Cancer Research Institute, Central South University, Changsha 410078, China.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha 410078, China.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China.
authors.forename: Binyuan
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Cancer Research Institute, Central South University, Changsha 410078, China.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha 410078, China.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China.
authors.forename: Ruili
authors.initials: R
authors.lastname: Sun
authors.affiliation: Cancer Research Institute, Central South University, Changsha 410078, China.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha 410078, China.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Fang
authors.affiliation: Cancer Research Institute, Central South University, Changsha 410078, China.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha 410078, China.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China.
authors.forename: Changfei
authors.initials: C
authors.lastname: Qin
authors.affiliation: Cancer Research Institute, Central South University, Changsha 410078, China.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha 410078, China.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Pan
authors.affiliation: Cancer Research Institute, Central South University, Changsha 410078, China.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha 410078, China.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China.
authors.forename: Li
authors.initials: L
authors.lastname: Peng
authors.affiliation: Cancer Research Institute, Central South University, Changsha 410078, China.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha 410078, China.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China.
authors.forename: Yuehui
authors.initials: Y
authors.lastname: Li
authors.affiliation: Cancer Research Institute, Central South University, Changsha 410078, China.|Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Changsha 410078, China.|Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China.
authors.forename: Guancheng
authors.initials: G
authors.lastname: Li
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000502:physiology; D002465:Cell Movement / Q000235:genetics*; D002478:Cells, Cultured; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006367:HeLa Cells; D056945:Hep G2 Cells; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D062085:RNA, Long Noncoding / Q000502:physiology*; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding
keywords: Slug; cervical cancer; lnc-CC3; long noncoding RNA (lncRNA); tumor metastasis