title: Outcomes of Renal Allograft Recipients With Hepatitis C.
abstract: BACKGROUND
  Studies on the effect of hepatitis C virus (HCV) infection showed decreased graft survival compared to HCV-negative matched patients. It was also identified as an independent risk factor for graft loss and mortality in kidney transplantation patients.
  
  
  OBJECTIVE
  This study was designed to evaluate the 10-year graft and patient outcomes of renal allograft recipients with HCV infection at the National Kidney and Transplant Institute.
  
  
  METHODS
  This is a retrospective study of patients who underwent renal transplantation with HCV infection and a group who were HCV-negative in the same post-transplantation period. Data were gathered from the in-patient and out-patient clinic records.
  
  
  RESULTS
  Patient survival was significantly lower in the HCV-positive than in the HCV-negative group. The mean duration of patient survival was 154.95 (+4.95) months (12 years and 10 months) in HCV-negative patients compared to 141 (+6.52) months (11 years and 9 months) in the HCV-positive group (P = .05). Graft survival did not differ significantly between HCV-positive and HCV-negative recipients (P = .734). The mean duration of graft survival was 137 (+7.68) months (11 years and 5 months) in HCV-negative patients compared to 130 (+6.84) months (10 years and 10 months) in HCV-positive patients. Short- and long-term outcomes including biopsy-proven acute rejection, transplant glomerulopathy, chronic allograft nephropathy, renal function, and proteinuria were similar in both groups.
  
  
  CONCLUSIONS
  Rejection, glomerulopathy, and renal function were similar in both groups. HCV progression was also observed in patients with detectable HCV-RNA 6 months before transplantation.
authors.affiliation: Department of Adult Nephrology, National Kidney and Transplant Institute, Quezon City, Philippines.
authors.forename: R
authors.initials: R
authors.lastname: Carpio
authors.affiliation: Department of Adult Nephrology, National Kidney and Transplant Institute, Quezon City, Philippines.
authors.forename: G E
authors.initials: GE
authors.lastname: Pamugas
authors.affiliation: Department of Adult Nephrology, National Kidney and Transplant Institute, Quezon City, Philippines. Electronic address: dr.radanguilan@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Danguilan
authors.affiliation: Department of Internal Medicine, National Kidney and Transplant Institute, Quezon City, Philippines.
authors.forename: E
authors.initials: E
authors.lastname: Que
mesh_terms: D000328:Adult; D064591:Allografts; D015331:Cohort Studies; D005260:Female; D006085:Graft Survival; D019698:Hepatitis C, Chronic / Q000401:mortality*; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality*; D008297:Male; D010679:Philippines / Q000453:epidemiology; D012367:RNA, Viral / Q000097:blood; D012189:Retrospective Studies
chemical_list: D012367:RNA, Viral