title: Reply.
authors.affiliation: Genentech Research and Early Development, South San Francisco, California.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Keir
authors.affiliation: Genentech Research and Early Development, South San Francisco, California.
authors.forename: Gaik W
authors.initials: GW
authors.lastname: Tew
authors.affiliation: Genentech Research and Early Development, South San Francisco, California.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Hackney