title: Aberrant structural and functional connectivity in the salience network and central executive network circuit in schizophrenia.
abstract: Consistent structural and functional abnormities have been detected in the salience network (SN) and the central-executive network (CEN) in schizophrenia. SN, known for its critical role in switching CEN and default-mode network (DMN) during cognitively demanding tasks, is proved to show aberrant regulation on the interaction between DMN and CEN in schizophrenia. However, it has not been elucidated whether there is a direct alteration of structural and functional connectivity between SN and CEN. 22 schizophrenia patients and 21 healthy controls were recruited for functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) in present study. The results show that schizophrenia patients had lower fractional anisotropy (FA) in right inferior long fasciculus (ILF), left inferior fronto-occipital fasciculus (IFOF) and callosal body than healthy controls. Significantly reduced functional connectivity was also found between right fronto-insular cortex (rFIC) and right posterior parietal cortex (rPPC). FA in right ILF was positively correlated with the functional connectivity of rFIC-rPPC. Therefore, we proposed a disruption of structural and functional connectivity and a positive anatomo-functional relationship in SN-CEN circuit, which might account for a core feature of schizophrenia.
authors.affiliation: Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022,China.
authors.forename: Xingui
authors.initials: X
authors.lastname: Chen
authors.affiliation: Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China.
authors.forename: Xiaoxuan
authors.initials: X
authors.lastname: He
authors.affiliation: Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022,China. Electronic address: wangkai1964@126.com.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.affiliation: Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China; Anhui Computer Application Institute of Traditional Chinese Medicine, Hefei, Anhui 230038, China. Electronic address: bqiu@ustc.edu.cn.
authors.forename: Bensheng
authors.initials: B
authors.lastname: Qiu
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D056324:Diffusion Tensor Imaging; D005260:Female; D006179:Gyrus Cinguli / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D010296:Parietal Lobe / Q000473:pathology / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000473:pathology / Q000503:physiopathology; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology*
keywords: Central executive network (CEN); Fractional anisotropy (FA); Functional connectivity; Salience network (SN); Schizophrenia