title: The Effects of Ferulic Acid Against Oxidative Stress and Inflammation in Formaldehyde-Induced Hepatotoxicity.
abstract: This study was designed to elucidate the protective effects of ferulic acid (FA) on formaldehyde-induced hepatotoxicity by measuring some routine biochemical parameters, cytokine levels, and oxidative stress-related parameters in addition to YKL-40 in male Wistar albino rats. Tissue superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities, and tissue malondialdehyde (MDA) levels were measured. Also, serum YKL-40, TNF-α, IL-6, IL-1β, IL-8, total protein, albumin, total bilirubin concentrations, and AST, ALT, ALP, and LDH activities were measured. Histological specimens were examined in light microscopy. Formaldehyde significantly increased tissue MDA, and serum cytokine levels and also decreased activities of antioxidant enzymes. FA treatment decreased MDA and cytokine levels and increased activities of antioxidant enzymes. FA also alleviated degeneration due to formaldehyde toxicity. We suggested that FA can be used as a promising hepatoprotective agent against formaldehyde toxicity because of the obvious beneficial effects on oxidative stress parameters.
authors.affiliation: Department of Biochemistry, Medical Faculty, Namik Kemal University, Namik Kemal Mahallesi Kampus Caddesi No:1, 59100, Tekirdag, Turkey. drfgerin@yahoo.com.
authors.forename: Fethullah
authors.initials: F
authors.lastname: Gerin
authors.affiliation: Department of Biochemistry, Medical Faculty, Namik Kemal University, Namik Kemal Mahallesi Kampus Caddesi No:1, 59100, Tekirdag, Turkey.
authors.forename: Hayriye
authors.initials: H
authors.lastname: Erman
authors.affiliation: Department of Histology and Embryology, Medical Faculty, Namik Kemal University, Namik Kemal Mahallesi Kampus Caddesi No:1, 59100, Tekirdag, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Erboga
authors.affiliation: Department of Physiology, Medical Faculty, Namik Kemal University, Namik Kemal Mahallesi Kampus Caddesi No:1, 59100, Tekirdag, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Sener
authors.affiliation: Department of Biochemistry, Medical Faculty, Namik Kemal University, Namik Kemal Mahallesi Kampus Caddesi No:1, 59100, Tekirdag, Turkey.
authors.forename: Ahsen
authors.initials: A
authors.lastname: Yilmaz
authors.affiliation: Department of Biochemistry, Medical Faculty, Namik Kemal University, Namik Kemal Mahallesi Kampus Caddesi No:1, 59100, Tekirdag, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Seyhan
authors.affiliation: Department of Biochemistry, Medical Faculty, Namik Kemal University, Namik Kemal Mahallesi Kampus Caddesi No:1, 59100, Tekirdag, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gurel
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D003373:Coumaric Acids / Q000494:pharmacology* / Q000627:therapeutic use; D016207:Cytokines / Q000097:blood; D005557:Formaldehyde / Q000009:adverse effects; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D018384:Oxidative Stress / Q000187:drug effects*; D010088:Oxidoreductases / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012130:Respiratory Hypersensitivity / Q000188:drug therapy
chemical_list: D003373:Coumaric Acids; D016207:Cytokines; D020011:Protective Agents; D005557:Formaldehyde; D008315:Malondialdehyde; C004999:ferulic acid; D010088:Oxidoreductases
keywords: YKL-40 protein; antioxidants; ferulic acid; formaldehyde; lipid peroxidation