title: ACTH Regulation of Adrenal SR-B1.
abstract: The adrenal gland is one of the prominent sites for steroid hormone synthesis. Lipoprotein-derived cholesterol esters (CEs) delivered via SR-B1 constitute the dominant source of cholesterol for steroidogenesis, particularly in rodents. Adrenocorticotropic hormone (ACTH) stimulates steroidogenesis through downstream actions on multiple components involved in steroidogenesis. Both acute and chronic ACTH treatments can modulate SR-B1 function, including its transcription, posttranscriptional stability, phosphorylation and dimerization status, as well as the interaction with other protein partners, all of which result in changes in the ability of SR-B1 to mediate HDL-CE uptake and the supply of cholesterol for conversion to steroids. Here, we provide a review of the recent findings on the regulation of adrenal SR-B1 function by ACTH.
authors.affiliation: The Division of Endocrinology, Stanford University, Stanford, CA, USA; Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Shen
authors.affiliation: The Division of Endocrinology, Stanford University, Stanford, CA, USA; Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
authors.forename: Salman
authors.initials: S
authors.lastname: Azhar
authors.affiliation: The Division of Endocrinology, Stanford University, Stanford, CA, USA; Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
authors.forename: Fredric B
authors.initials: FB
authors.lastname: Kraemer
keywords: ACTH; SR-B1; adrenal; cholesterol