title: Short-term changes of intraocular pressure and ocular perfusion pressure after intravitreal injection of bevacizumab or ranibizumab.
abstract: BACKGROUND
  The aim of this study was to investigate the effect of intravitreal anti-vascular endothothelial growth factor (VEGF) injection on intraocular pressure (IOP) and mean ocular perfusion pressure (MOPP).
  
  
  METHODS
  MOPP results were obtained by measuring mean arterial pressure (MAP) and IOP just before the injection, immediately after the injection, at 30 min, 1 day, and 1 week after injection from 65 eyes of 42 patients.
  
  
  RESULTS
  Pre-injection mean IOP was 16.66 ± 3.50 mmHg, and mean IOP was 43.81 ± 9.69 mmHg immediately after the injection, 17.57 ± 4.44 mmHg at 30 min, 15.00 ± 4.21 mmHg at 1 day, and 15.90 ± 3.63 mmHg at 1 week after the injection. Pre-injection mean MOPP was 46.39 ± 5.78 mmHg, and mean MOPP was 25.14 ± 8.79 mmHg immediately after the injection, 45.87 ± 6.31 mmHg at 30 min, 46.93 ± 6.25 mmHg at 1 day, and 46.50 ± 4.94 mmHg at 1 week after the injection.
  
  
  CONCLUSIONS
  The instant increase in IOP by intravitreal anti-VEGF injection led to a transient decrease in MOPP. Based on this finding, the instant increase in IOP after intravitreal anti-VEGF injection does not significantly impair retinal blood flow.
authors.affiliation: Department of Ophthalmology, School of Medicine, Eulji University, Daejeon, Korea.
authors.forename: Jong Wook
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, School of Medicine, Eulji University, Daejeon, Korea.
authors.forename: Hoon
authors.initials: H
authors.lastname: Park
authors.affiliation: Department of Ophthalmology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, Korea.
authors.forename: Jeong Han
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Department of Ophthalmology, School of Medicine, Eulji University, Daejeon, Korea.
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, Korea.
authors.forename: Sang Woong
authors.initials: SW
authors.lastname: Moon
authors.affiliation: Department of Ophthalmology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, Korea.
authors.forename: Ja Heon
authors.initials: JH
authors.lastname: Kang
authors.affiliation: Department of Ophthalmology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, #892 Dongnam-ro, Gangdong-gu, Seoul, Korea. eyedockim@naver.com.
authors.forename: Young Gyun
authors.initials: YG
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D000068258:Bevacizumab / Q000008:administration & dosage / Q000009:adverse effects; D001794:Blood Pressure / Q000502:physiology*; D001916:Brachial Artery / Q000502:physiology; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D058449:Intravitreal Injections / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000503:physiopathology; D011446:Prospective Studies; D000069579:Ranibizumab / Q000008:administration & dosage / Q000009:adverse effects; D012164:Retinal Diseases / Q000188:drug therapy; D055815:Young Adult
chemical_list: D020533:Angiogenesis Inhibitors; D000068258:Bevacizumab; D000069579:Ranibizumab
keywords: Intraocular pressure; Intravitreal injection; Mean ocular perfusion pressure