title: Hydroxylation-independent HIF-1α stabilization through PKA: A new paradigm for hypoxia signaling.
abstract: In this issue of Science Signaling, Bullen et al demonstrate that protein kinase A (PKA) phosphorylates and stimulates the transcriptional activity of hypoxia-inducible transcription factor-1α (HIF-1α). This finding may have implications in diseases processes that occur at the interface of hypoxia and inflammation, where HIF-1α stabilization can function to dampen hypoxia-driven inflammation.
authors.affiliation: Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA. Mucosal Inflammation Program, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
authors.forename: Eóin N
authors.initials: EN
authors.lastname: McNamee
authors.affiliation: Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA. Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Vohwinkel
authors.affiliation: Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA. Mucosal Inflammation Program, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA. holger.eltzschig@ucdenver.edu.
authors.forename: Holger K
authors.initials: HK
authors.lastname: Eltzschig
mesh_terms: D017868:Cyclic AMP-Dependent Protein Kinases; D006801:Humans; D006900:Hydroxylation; D000860:Hypoxia; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D010766:Phosphorylation
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D017868:Cyclic AMP-Dependent Protein Kinases