title: Prenatal Screening for Thrombophilias: Indications and Controversies, an Update.
abstract: Pregnancy is associated with increased clotting potential and decreased fibrinolysis. Women with thrombophilias have an increased risk of venous thromboembolism during pregnancy. At least 50% of cases of venous thromboembolism in pregnant women are associated with an inherited or acquired thrombophilia. Acquired thrombophilias have also been linked with adverse pregnancy outcomes such as recurrent pregnancy loss, intrauterine fetal demise, early onset severe preeclampsia, placental abruption, and fetal growth restriction. This article addresses indications for thrombophilia testing, the appropriate laboratory tests, and timing of testing to ensure reliability of results.
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of South Florida Morsani College of Medicine, 2 Tampa General Circle, 6th Floor, Tampa, FL 33606, USA. Electronic address: alouisjacques@health.usf.edu.
authors.forename: Adetola F
authors.initials: AF
authors.lastname: Louis-Jacques
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of South Florida Morsani College of Medicine, 2 Tampa General Circle, 6th Floor, Tampa, FL 33606, USA.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Maggio
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of South Florida Morsani College of Medicine, 2 Tampa General Circle, 6th Floor, Tampa, FL 33606, USA.
authors.forename: Stephanie T
authors.initials: ST
authors.lastname: Romero
mesh_terms: D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis* / Q000235:genetics; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D019851:Thrombophilia / Q000150:complications / Q000175:diagnosis* / Q000235:genetics
keywords: Acquired thrombophilias; Adverse pregnancy outcomes; Inherited thrombophilias; Pregnancy; Thrombophilia; Venous thromboembolism