title: A Concise Route to the Strongylophorines.
abstract: An efficient eight-step semisynthesis of strongylophorine-2 from the abundant building block isocupressic acid is reported. The route represents the first synthetic entry into this class of natural products and provides access to six additional family members. A novel iron(III)-mediated rearrangement-cyclization cascade and a directed photochemical sp(3) C-H δ-lactonization are the key transformations that enable concise assembly of these bioactive polycyclic meroterpenoids.
authors.affiliation: Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark.
authors.forename: Wanwan
authors.initials: W
authors.lastname: Yu
authors.affiliation: Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark.
authors.forename: Per
authors.initials: P
authors.lastname: Hjerrild
authors.affiliation: Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark.
authors.forename: Jacob
authors.initials: J
authors.lastname: Overgaard
authors.affiliation: Department of Chemistry, Aarhus University, Langelandsgade 140, 8000, Aarhus C, Denmark. thpou@chem.au.dk.
authors.forename: Thomas B
authors.identifier: 0000-0002-0763-9996
authors.initials: TB
authors.lastname: Poulsen
keywords: C−H activation; cascade reactions; cyclization; natural products; semisynthesis