title: Pyristriatins A and B: Pyridino-Cyathane Antibiotics from the Basidiomycete Cyathus cf. striatus.
abstract: Two novel pyridino-cyathane diterpenoids, pyristriatins A and B (1 and 2), together with striatin C (3) were isolated from cultures of Cyathus cf. striatus, a basidiomycete that was found during a field trip in northern Thailand. The pyristriatins showed antimicrobial effects against Gram-positive bacteria and fungi. The isolation, structure elucidation, relative configuration, and biological and cytotoxic activity are described. Their structures were assigned by HRMS and NMR spectroscopy. We also describe the first 2D NMR assignment of striatin C. Pyristriatins A and B are the first cyathane natural products featuring a pyridine ring.
authors.affiliation: Department of Microbial Drugs, Helmholtz Centre for Infection Research; and German Centre for Infection Research (DZIF) , partner site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Richter
authors.affiliation: Department of Microbial Drugs, Helmholtz Centre for Infection Research; and German Centre for Infection Research (DZIF) , partner site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany.|Department of Chemistry, Faculty of Science, Aswan University , Aswan 81528, Egypt.
authors.forename: Soleiman E
authors.initials: SE
authors.lastname: Helaly
authors.affiliation: Institute of Excellence in Fungal Research and School of Science, Mae Fah Luang University , Chiang Rai 57100, Thailand.
authors.forename: Benjarong
authors.initials: B
authors.lastname: Thongbai
authors.affiliation: Institute of Excellence in Fungal Research and School of Science, Mae Fah Luang University , Chiang Rai 57100, Thailand.
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Hyde
authors.affiliation: Department of Microbial Drugs, Helmholtz Centre for Infection Research; and German Centre for Infection Research (DZIF) , partner site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
authors.forename: Marc
authors.initials: M
authors.lastname: Stadler
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D055365:Cyathus / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008264:Macrophages; D015394:Molecular Structure; D013785:Thailand
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; C497675:cyathane; C000618918:pyristriatin A; C000618892:pyristriatin B