title: Microbial transformation of the anti-diabetic agent corosolic acid by Cunninghamella echinulata.
abstract: The pentacyclic triterpenoid corosolic acid was metabolized by Cunninghamella echinulata CGMCC 3.2000 to its C-24 aldehyde group metabolite and five other hydroxylated metabolites: madasiatic acid (2), 2α, 3β, 7β-trihydroxyurs-12-en-28-oic acid (3), 2α, 3β, 15α-trihydroxyurs-12-en-28-oic acid (4), 2α, 3β, 6β, 7β-tetrahydroxyurs-12-en-28-oic acid (5), 2α, 3β, 7β, 15α-tetrahydroxyurs-12-en-28-oic acid (6), and 2α, 3β,7β-trihydroxy-24-al-urs-12-en-28-oic acid (7); compounds 3, 5, and 7 were new compounds. The α-glucosidase inhibitory effects of the metabolites were also evaluated.
authors.affiliation: a Navy Medical Research Institute , Shanghai 200433 , China.
authors.forename: Xu
authors.initials: X
authors.lastname: Feng
authors.affiliation: b State Key Laboratory of Bioreactor Engineering , East China University of Science and Technology , Shanghai 200207 , China.
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Lu
authors.affiliation: a Navy Medical Research Institute , Shanghai 200433 , China.|c Shanghai Ocean University , Shanghai 201306 , China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: a Navy Medical Research Institute , Shanghai 200433 , China.
authors.forename: Dai-Ping
authors.initials: DP
authors.lastname: Li
authors.affiliation: a Navy Medical Research Institute , Shanghai 200433 , China.
authors.forename: Ying-Xin
authors.initials: YX
authors.lastname: Zou
authors.affiliation: a Navy Medical Research Institute , Shanghai 200433 , China.
authors.forename: Yi-Qun
authors.initials: YQ
authors.lastname: Fang
authors.affiliation: a Navy Medical Research Institute , Shanghai 200433 , China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Chu
mesh_terms: D001711:Biotransformation; D020093:Cunninghamella / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000188:drug therapy; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D000520:alpha-Glucosidases / Q000187:drug effects / Q000378:metabolism
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D014315:Triterpenes; C113861:corosolic acid; D000520:alpha-Glucosidases
keywords: Cunninghamella echinulata; Triterpenoid; anti-diabetic; biotransformation; corosolic acid