title: Charting a course through the CEAs: diagnosis and management of medullary thyroid cancer.
abstract: Medullary thyroid cancer (MTC) is an uncommon thyroid cancer that requires a high index of suspicion to facilitate diagnosis of early-stage disease amenable to surgical cure. The challenges of diagnosis, as well as management in the setting of persistent disease, are explored in the context of a case presenting with the incidental finding of elevated carcinoembryonic antigen (CEA) and an (18) F-fluorodeoxyglucose positron emission tomography ((18) F-FDG-PET)-positive thyroid incidentaloma detected following treatment of colorectal cancer. Strategies to individualize prognosis, and emerging PET-based imaging modalities, particularly the potential role of (18) F-DOPA-PET in staging, are reviewed.
authors.affiliation: Department of Endocrinology, John Hunter Hospital, Newcastle, Australia.|School of Medicine and Public Health, University of Newcastle, Newcastle, Australia.
authors.forename: Christopher W
authors.identifier: 0000-0002-9652-6562
authors.initials: CW
authors.lastname: Rowe
authors.affiliation: School of Medicine and Public Health, University of Newcastle, Newcastle, Australia.|Department of Surgery, John Hunter Hospital, Newcastle, Australia.
authors.forename: Cino
authors.initials: C
authors.lastname: Bendinelli
authors.affiliation: Department of Endocrinology, John Hunter Hospital, Newcastle, Australia.
authors.forename: Shaun
authors.initials: S
authors.lastname: McGrath
mesh_terms: D002272:Carcinoembryonic Antigen / Q000032:analysis*; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis* / Q000628:therapy*; D019468:Disease Management; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods; D057285:Precision Medicine / Q000379:methods; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D002272:Carcinoembryonic Antigen