title: A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents.
abstract: A sulfonamide 1-tosyl-1-H-benzo(d)imidazol-2-amine (TBZA) and three new complexes of Co(II), Cu(II), and Zn(II) have been synthesized. The compounds have been characterized by elemental analyses, FTIR,1H, and13C-NMR spectroscopy. The structure of the TBZA, and its Co(II) and Cu(II) complexes, was determined by X-ray diffraction methods. TBZA and its Co(II) complex crystallize in the triclinic P-1 space group, while the Cu(II) complex crystallizes in the monoclinic P21/c space group. Antifungal activity was screened against eight pathogenic yeasts: Candida albicans (DMic 972576), Candida krusei (DMic 951705), Candida glabrata (DMic 982882), Candida tropicalis (DMic 982884), Candida dubliniensis (DMic 93695), Candida guilliermondii (DMic 021150), Cryptococcus neoformans (ATCC 24067), and Cryptococcus gattii (ATCC MYA-4561). Results on the inhibition of various human (h) CAs, hCA I, II, IV, VII, IX, and XII, and pathogenic beta and gamma CAs are also reported.
authors.affiliation: a INTEQUI (CONICET, CCT-San Luis), Área de Química General e Inorgánica, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis , San Luis , Argentina.
authors.forename: Jorge R A
authors.initials: JR
authors.lastname: Diaz
authors.affiliation: b INQUISAL (CONICET, CCT-San Luis), Departamento de Química, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis , San Luis , Argentina.
authors.forename: Martín
authors.initials: M
authors.lastname: Fernández Baldo
authors.affiliation: c LANADI - IFLP (CONICET, CCT-La Plata), Departamento de Física, Facultad de Ciencias Exactas, Universidad Nacional de La Plata , La Plata , Argentina.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Echeverría
authors.affiliation: d Instituto de Matemática Aplicada San Luis (IMASL-CONICET), Universidad Nacional de San Luis , San Luis , Argentina.
authors.forename: Héctor
authors.initials: H
authors.lastname: Baldoni
authors.affiliation: e Neurofarba Department, University of Florence , Sesto Fiorentino (Firenze) , Italy , and.
authors.forename: Daniela
authors.initials: D
authors.lastname: Vullo
authors.affiliation: f CEQUINOR (CONICET, CCT-La Plata), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de la Plata , La Plata , Argentina.
authors.forename: Delia B
authors.initials: DB
authors.lastname: Soria
authors.affiliation: e Neurofarba Department, University of Florence , Sesto Fiorentino (Firenze) , Italy , and.
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
authors.affiliation: a INTEQUI (CONICET, CCT-San Luis), Área de Química General e Inorgánica, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis , San Luis , Argentina.
authors.forename: Gerardo E
authors.initials: GE
authors.lastname: Camí
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002256:Carbonic Anhydrases / Q000378:metabolism*; D003035:Cobalt / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D003454:Cryptococcus / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D002257:Carbonic Anhydrase Inhibitors; D009942:Organometallic Compounds; D013449:Sulfonamides; D003035:Cobalt; D003300:Copper; D002256:Carbonic Anhydrases; D015032:Zinc
keywords: Antifungal; carbonic anhydrase; metal complex; sulfonamide; thermal stability