title: Clinical significance of long noncoding RNA SPRY4-IT1 in melanoma patients.
abstract: Long noncoding RNA SPRY4-IT1 has been reported to promote melanoma cell growth and invasion, and to block apoptosis. The purpose of this study was to investigate the clinical significance of SPRY4-IT1 in patients with malignant melanoma. The relative expression levels of SPRY4-IT1 were measured in plasma samples from 70 patients and 79 healthy controls by quantitative reverse transcriptase polymerase chain reaction. SPRY4-IT1 expression is high in melanoma patients but low in healthy controls, and is closely associated with tumor site and tumor stage. Elevated SPRY4-IT1 significantly reduces overall survival rates of patients and is considered as an independent prognostic factor in patients with melanoma. The prognostic nomogram shows a good prediction of the probability of 5-year overall survival of patients with melanoma (c-index: 0.72). The calibration curve for the probability of survival presents good agreement between actual outcomes and predictive consequences. In summary, SPRY4-IT1 may be a potential prognostic marker and a potential therapeutic target.
authors.affiliation: Department of Dermatology The People's Hospital of Chizhou China.
authors.forename: Teng
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Dermatology The First Affiliated Hospital Anhui Medical University Hefei China.
authors.forename: Song-Ke
authors.initials: SK
authors.lastname: Shen
authors.affiliation: Department of Dermatology Wanbei Coal-Electricity Group General Hospital Suzhou China.
authors.forename: Jian-Gui
authors.initials: JG
authors.lastname: Xiong
authors.affiliation: Department of Dermatology The People's Hospital of Chizhou China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Dermatology The People's Hospital of Chizhou China.
authors.forename: Han-Qi
authors.initials: HQ
authors.lastname: Zhang
authors.affiliation: Department of Infection No. 2 People's Hospital of Fuyang China.
authors.forename: Hai-Jun
authors.initials: HJ
authors.lastname: Liu
authors.affiliation: Department of Dermatology The People's Hospital of Chizhou China.
authors.forename: Zheng-Gen
authors.initials: ZG
authors.lastname: Lu
keywords: SPRY4‐IT1; long noncoding RNA; melanoma; overall survival