title: Dexamethasone Is One of the Factors Minimizing the Inner Ear Damage from Electrode Insertion in Cochlear Implantation.
abstract: The aim of this study was to investigate the efficacy of preoperative and intraoperative steroid administration for inner ear protection in cochlear implantation (CI). Nineteen subjects who underwent CI were included in the study, and 10 subjects were enrolled as controls (steroid-administered group, n = 19; control group, n = 10). Dexamethasone (dexamethasone sodium phosphate, 5 mg/ml) was systemically administered preoperatively (1 ml) and topically applied during CI (0.5 ml). The extent of hearing preservation (HP) after CI and the change in the bithermal caloric response were evaluated. Hearing level was calculated using mean thresholds [(250 Hz + 500 Hz + 1,000 Hz + 2,000 Hz)/4]. Preoperative hearing thresholds were similar in the steroid-administered and control groups (100.92 ± 12.60 vs. 103.29 ± 14.39 dB, p = 0.650). The mean thresholds significantly increased in both groups after surgery (108.46 ± 14.08 dB, p = 0.006, for the steroid-administered group; 117.50 ± 6.34 dB, p = 0.027, for the control group), and the difference between the groups was also significant (p = 0.027). The postoperative shift in the hearing thresholds at frequencies of 500 and 1,000 Hz was significant in the steroid-administered group and that at the frequencies of 500, 1,000 and 2,000 Hz was significant in the control group. However, the extent of the shift in hearing threshold levels at each frequency was not significantly different between the groups. Preservation of hearing thresholds was compared between the groups, and there were significantly more subjects with complete and partial HP in the steroid-administered group than in the control group (p = 0.008). The preoperative caloric response was maintained after CI in the steroid-administered group. This study suggests that the perioperative use of a steroid could minimize the inner ear damage after CI.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Kyungpook National University College of Medicine, Daegu, South Korea.
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Cho
authors.forename: Kyu-Yup
authors.initials: KY
authors.lastname: Lee
authors.forename: Hongsoo
authors.initials: H
authors.lastname: Choi
authors.forename: Jeong Hun
authors.initials: JH
authors.lastname: Jang
authors.forename: Sang Heun
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D001301:Audiometry, Pure-Tone; D002150:Caloric Tests; D016022:Case-Control Studies; D019929:Cochlear Implantation / Q000379:methods*; D015331:Cohort Studies; D003638:Deafness / Q000534:rehabilitation*; D003907:Dexamethasone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007758:Ear, Inner; D004567:Electrodes, Implanted; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D011184:Postoperative Period; D011300:Preoperative Care / Q000379:methods; D014717:Vertigo / Q000517:prevention & control*
chemical_list: D005938:Glucocorticoids; C004180:dexamethasone 21-phosphate; D003907:Dexamethasone