title: Update on the surgical management of ovarian neoplasms in children and adolescents: analysis on 32 cases.
abstract: This study analyzes updated clinical, diagnostic, and surgical directions for the treatment of ovarian neoplasms in children and adolescents, comparing them with a retrospective analysis of 32 cases treated in two Pediatric Surgery University Institutions. From January 2005 to December 2015, 32 pediatric patients were surgically treated for 32 ovarian tumors: 28 (87.5%) benign and 4 (12.5%) malignant neoplastic lesions. Median age at surgery was 11.2 years (12.8 years in patients with benign neoplasms, 7.25 years in patients with malignant ones). All patients with malignant and 25% of patients with benign ovarian lesions had elevated serum level of tumors markers. The surgical approach was laparotomic in 62.5% and laparoscopic in 37.5%; 81.2% surgeries were performed in elective surgery and 18.8% in emergency. Intraoperative frozen section analysis was performed in 18.75% of patients. The most frequent surgery (96.8%) was unilateral oophorectomy. After a median follow-up of 76 months (range 6-132 months), 31/32 patients are alive and disease-free. In case of malignant tumors, fertility-sparing surgery with accurate staging must be performed. Laparoscopic multiport is the gold standard approach for benign pediatric ovarian neoplasms, but the use of laparoscopy in full respect of oncological principles also for early stage malignant tumors is currently increased.
authors.affiliation: a Chair of Pediatric Surgery, Adolescent and Young Adult Endocrine Surgery Division, Department of Surgical, Medical, Molecular Pathology and of the Critical Area, Universita degli Studi di Pisa , Pisa , Italy and.
authors.forename: Claudio
authors.initials: C
authors.lastname: Spinelli
authors.affiliation: a Chair of Pediatric Surgery, Adolescent and Young Adult Endocrine Surgery Division, Department of Surgical, Medical, Molecular Pathology and of the Critical Area, Universita degli Studi di Pisa , Pisa , Italy and.
authors.forename: Silvia
authors.initials: S
authors.lastname: Strambi
authors.affiliation: a Chair of Pediatric Surgery, Adolescent and Young Adult Endocrine Surgery Division, Department of Surgical, Medical, Molecular Pathology and of the Critical Area, Universita degli Studi di Pisa , Pisa , Italy and.
authors.forename: Concetta
authors.initials: C
authors.lastname: Liloia
authors.affiliation: b Department of Pediatric Surgery , Universita degli Studi di Firenze , Firenze , Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Bertocchini
authors.affiliation: b Department of Pediatric Surgery , Universita degli Studi di Firenze , Firenze , Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Messineo
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D010051:Ovarian Neoplasms / Q000601:surgery*; D016896:Treatment Outcome
keywords: Fertility-sparing surgery; ovarian torsion; ovarian tumor; pediatric ovarian neoplasm