title: Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites.
abstract: The apicomplexan parasites that cause malaria and babesiosis invade and proliferate within erythrocytes. To assess the potential for common antiparasitic treatments, we measured the sensitivities of multiple species of Plasmodium and Babesia parasites to the chemically diverse collection of antimalarial compounds in the Malaria Box library. We observed that these parasites share sensitivities to a large fraction of the same inhibitors and we identified compounds with strong babesiacidal activity.
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
authors.forename: Aditya S
authors.initials: AS
authors.lastname: Paul
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
authors.forename: Cristina K
authors.initials: CK
authors.lastname: Moreira
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
authors.forename: Brendan
authors.initials: B
authors.lastname: Elsworth
authors.affiliation: Department of Infectious Diseases and Pathology, University of Florida, Gainesville, Florida, USA Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Allred
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA mduraisi@hsph.harvard.edu.
authors.forename: Manoj T
authors.initials: MT
authors.lastname: Duraisingh
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D001403:Babesia / Q000187:drug effects / Q000472:pathogenicity; D001404:Babesiosis / Q000469:parasitology*; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology*; D010271:Parasites / Q000187:drug effects* / Q000472:pathogenicity*; D010961:Plasmodium / Q000187:drug effects / Q000472:pathogenicity
chemical_list: D000962:Antimalarials