title: Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation-Novel Paradigm and Therapeutic Potential.
abstract: There are limitations in the current classification of danger-associated molecular patterns (DAMP) receptors. To overcome these limitations, we propose a new paradigm by using endogenous metabolites lysophospholipids (LPLs) as a prototype. By utilizing a data mining method we pioneered, we made the following findings: (1) endogenous metabolites such as LPLs at basal level have physiological functions; (2) under sterile inflammation, expression of some LPLs is elevated. These LPLs act as conditional DAMPs or anti-inflammatory homeostasis-associated molecular pattern molecules (HAMPs) for regulating the progression of inflammation or inhibition of inflammation, respectively; (3) receptors for conditional DAMPs and HAMPs are differentially expressed in human and mouse tissues; and (4) complex signaling mechanism exists between pro-inflammatory mediators and classical DAMPs that regulate the expression of conditional DAMPs and HAMPs. This novel insight will facilitate identification of novel conditional DAMPs and HAMPs, thus promote development of new therapeutic targets to treat inflammatory disorders.
authors.affiliation: Department of Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, China.|Centers for Metabolic Disease Research, Cardiovascular Research & Thrombosis Research, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 1059, Philadelphia, PA, 19140, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Centers for Metabolic Disease Research, Cardiovascular Research & Thrombosis Research, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 1059, Philadelphia, PA, 19140, USA.
authors.forename: Ya-Feng
authors.initials: YF
authors.lastname: Li
authors.affiliation: Centers for Metabolic Disease Research, Cardiovascular Research & Thrombosis Research, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 1059, Philadelphia, PA, 19140, USA.
authors.forename: Gayani
authors.initials: G
authors.lastname: Nanayakkara
authors.affiliation: Centers for Metabolic Disease Research, Cardiovascular Research & Thrombosis Research, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 1059, Philadelphia, PA, 19140, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Department of Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liang
authors.affiliation: Centers for Metabolic Disease Research, Cardiovascular Research & Thrombosis Research, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 1059, Philadelphia, PA, 19140, USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: Cole
authors.affiliation: Centers for Metabolic Disease Research, Cardiovascular Research & Thrombosis Research, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 1059, Philadelphia, PA, 19140, USA.
authors.forename: William Y
authors.initials: WY
authors.lastname: Yang
authors.affiliation: Centers for Metabolic Disease Research, Cardiovascular Research & Thrombosis Research, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 1059, Philadelphia, PA, 19140, USA.
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Li
authors.affiliation: Centers for Metabolic Disease Research, Cardiovascular Research & Thrombosis Research, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 1059, Philadelphia, PA, 19140, USA.
authors.forename: Ramon
authors.initials: R
authors.lastname: Cueto
authors.affiliation: Centers for Metabolic Disease Research, Cardiovascular Research & Thrombosis Research, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 1059, Philadelphia, PA, 19140, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Yu
authors.affiliation: Centers for Metabolic Disease Research, Cardiovascular Research & Thrombosis Research, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 1059, Philadelphia, PA, 19140, USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Centers for Metabolic Disease Research, Cardiovascular Research & Thrombosis Research, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, 3500 North Broad Street, MERB 1059, Philadelphia, PA, 19140, USA. xfyang@temple.edu.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Yang
mesh_terms: D000818:Animals; D019295:Computational Biology; D057225:Data Mining; D030541:Databases, Genetic; D004195:Disease Models, Animal; D020869:Gene Expression Profiling / Q000379:methods; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism*; D008246:Lysophospholipids / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D011485:Protein Binding; D049312:Receptors, Lysophospholipid / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008246:Lysophospholipids; D049312:Receptors, Lysophospholipid
keywords: Atherosclerosis; Danger-associated molecular pattern molecules receptor; Homeostasis-associated molecular pattern molecules receptor; Lysophospholipid receptor; Rheumatoid arthritis