title: Combined treatment with sitagliptin and vitamin D in a patient with latent autoimmune diabetes in adults.
abstract: Latent autoimmune diabetes in adults (LADA) is a relatively new type of diabetes with a clinical phenotype of type 2 diabetes (T2D) and an immunological milieu characterized by high titers of islet autoantibodies, resembling the immunological profile of type 1 diabetes (T1D). Herein, we report a case of a young male, diagnosed with LADA based on both clinical presentation and positive anti-glutamic acid decarboxylase antibodies (GAD-abs), which were normalized after combined treatment with a dipeptidyl peptidase-4 inhibitor (DPP-4) (sitagliptin) and cholecalciferol.
  
  
  CONCLUSIONS
  Anti-glutamic acid decarboxylase antibodies (GAD-abs) titers in young patients being previously diagnosed as type 2 diabetes (T2D) may help establish the diagnosis of latent autoimmune diabetes in adults (LADA).Sitagliptin administration in patients with LADA might prolong the insulin-free period.Vitamin D administration in patients with LADA might have a protective effect on the progression of the disease.
authors.affiliation: Diabetes Center of 1st Department of Internal Medicine, AHEPA University Hospital , Thessaloniki , Greece.
authors.forename: E
authors.initials: E
authors.lastname: Rapti
authors.affiliation: Diabetes Center of 1st Department of Internal Medicine, AHEPA University Hospital , Thessaloniki , Greece.
authors.forename: S
authors.initials: S
authors.lastname: Karras
authors.affiliation: Diabetes Center of 1st Department of Internal Medicine, AHEPA University Hospital , Thessaloniki , Greece.
authors.forename: M
authors.initials: M
authors.lastname: Grammatiki
authors.affiliation: Diabetes Center of 1st Department of Internal Medicine, AHEPA University Hospital , Thessaloniki , Greece.
authors.forename: A
authors.initials: A
authors.lastname: Mousiolis
authors.affiliation: Diabetes Center of 1st Department of Internal Medicine, AHEPA University Hospital , Thessaloniki , Greece.
authors.forename: X
authors.initials: X
authors.lastname: Tsekmekidou
authors.affiliation: Diabetes Center of 1st Department of Internal Medicine, AHEPA University Hospital , Thessaloniki , Greece.
authors.forename: E
authors.initials: E
authors.lastname: Potolidis
authors.affiliation: Diabetes Center of 1st Department of Internal Medicine, AHEPA University Hospital , Thessaloniki , Greece.
authors.forename: P
authors.initials: P
authors.lastname: Zebekakis
authors.affiliation: 1st Department of Internal Medicine, AHEPA University Hospital , Thessaloniki , Greece.
authors.forename: M
authors.initials: M
authors.lastname: Daniilidis
authors.affiliation: Diabetes Center of 1st Department of Internal Medicine, AHEPA University Hospital , Thessaloniki , Greece.
authors.forename: K
authors.initials: K
authors.lastname: Kotsa