title: Developmental Origins of Health and Disease in swine: implications for animal production and biomedical research.
abstract: The concept of Developmental Origins of Health and Disease (DOHaD) addresses, from a large set of epidemiological evidences in human beings and translational studies in animal models, both the importance of genetic predisposition and the determinant role of maternal nutrition during pregnancy on adult morphomics and homeostasis. Compelling evidences suggest that both overnutrition and undernutrition may modify the intrauterine environment of the conceptus and may alter the expression of its genome and therefore its phenotype during prenatal and postnatal life. In fact, the DOHaD concept is an extreme shift in the vision of the factors conditioning adult phenotype and supposes a drastic change from a gene-centric perspective, only modified by lifestyle and nutritional strategies during juvenile development and adulthood, to a more holistic approach in which environmental, parental, and prenatal conditions are strongly determining postnatal development and homeostasis. The implications of DOHaD are profound in all the mammalian species and the present review summarizes current knowledge on causes and consequences of DOHaD in pigs, both for meat production and as a well-recognized model for biomedicine research.
authors.affiliation: Comparative Physiology Lab-RA, SGIT-INIA, Madrid, Spain; Department of Veterinary Medicine, University of Sassari, Sassari, Italy. Electronic address: bulnes@inia.es.
authors.forename: A
authors.initials: A
authors.lastname: Gonzalez-Bulnes
authors.affiliation: Comparative Physiology Lab-RA, SGIT-INIA, Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Astiz
authors.affiliation: Department of Animal Genetics, SGIT-INIA, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Ovilo
authors.affiliation: Faculty of Veterinary, UCM, Madrid, Spain.
authors.forename: C J
authors.initials: CJ
authors.lastname: Lopez-Bote
authors.affiliation: Comparative Physiology Lab-RA, SGIT-INIA, Madrid, Spain; INRA, UMR1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France.
authors.forename: L
authors.initials: L
authors.lastname: Torres-Rovira
authors.affiliation: Faculty of Veterinary, UCM, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Barbero
authors.affiliation: Faculty of Veterinary, UCM, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Ayuso
authors.affiliation: Department of Animal Genetics, SGIT-INIA, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Garcia-Contreras
authors.affiliation: Faculty of Veterinary, UCM, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Vazquez-Gomez
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D005260:Female; D020022:Genetic Predisposition to Disease; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013552:Swine; D013553:Swine Diseases / Q000235:genetics / Q000517:prevention & control*
keywords: Conceptus; Pregnancy; Prenatal programming; Swine