title: Epigallocatechin-3-gallate ameliorates radiation-induced acute skin damage in breast cancer patients undergoing adjuvant radiotherapy.
abstract: There are few effective treatment options for radiation-induced dermatitis in breast cancer patients. We conducted a single-arm trial to tested the hypothesis that topical epigallocatechin-3-gallate (EGCG) is effective against radiation-induced dermatitis in breast cancer patients undergoing radiotherapy. Forty-nine patients participated in this study. The patients underwent mastectomy followed by adjuvant radiotherapy. Topical EGCG was applied daily, starting when grade I dermatitis appeared and ending two weeks after radiotherapy. The maximum dermatitis observed during the EGCG treatment was as follows: Grade 1 toxicity, 71.4% (35 patients); grade 2 toxicity, 28.6% (14 patients); there were no patients with grade 3 or 4 toxicity. The majority of the radiation-induced dermatitis was observed 1 week after the end of radiotherapy. EGCG reduced the pain in 85.7% of patients, burning-feeling in 89.8%, itching in 87.8%, pulling in 71.4%, and tenderness in 79.6%. These findings suggest topical EGCG may be an effective treatment for radiation-induced dermatitis and has acceptable toxicity.
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan, Shandong, China.
authors.forename: Wanqi
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Radiation Oncology, Jinan Fourth People's Hospital, Jinan, Shandong, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jia
authors.affiliation: Shandong Key Laboratory of Radiation Oncology, Jinan, Shandong, China.
authors.forename: Guanxuan
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan, Shandong, China.
authors.forename: Hanxi
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Radiology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan, Shandong, China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan, Shandong, China.
authors.forename: Xiangjiao
authors.initials: X
authors.lastname: Meng
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan, Shandong, China.
authors.forename: Xianguang
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan, Shandong, China.
authors.forename: Ligang
authors.initials: L
authors.lastname: Xing
authors.affiliation: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan, Shandong, China.|Shandong Key Laboratory of Radiation Oncology, Jinan, Shandong, China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Yu
authors.affiliation: Shandong Key Laboratory of Radiation Oncology, Jinan, Shandong, China.
authors.forename: Meizhu
authors.initials: M
authors.lastname: Zheng
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D001940:Breast / Q000528:radiation effects; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D002392:Catechin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D059408:Pain Management / Q000379:methods; D011446:Prospective Studies; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011855:Radiodermatitis / Q000188:drug therapy*; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D011837:Radiation-Protective Agents; D002392:Catechin; C045651:epigallocatechin gallate
keywords: breast neoplasms; dermatitis; epigallocatechin-3-gallate; radiation