title: Anti-inflammatory and anti-oxidative effects of alpha-lipoic acid in experimentally induced acute otitis media.
abstract: OBJECTIVE
  To investigate the anti-inflammatory, anti-oxidative and tissue protective effects, as well as the potential therapeutic role, of alpha-lipoic acid in experimentally induced acute otitis media.
  
  
  METHODS
  Twenty-five guinea pigs were assigned to one of five groups: a control (non-otitis) group, and otitis-induced groups treated with saline, penicillin G, alpha-lipoic acid, or alpha-lipoic acid plus penicillin G. Tissue samples were histologically analysed, and oxidative parameters in tissue samples were measured and compared between groups.
  
  
  RESULTS
  The epithelial integrity was better preserved, and histological signs of inflammation and secretory metaplasia were decreased, in all groups compared to the saline treated otitis group. In the alpha-lipoic acid plus penicillin G treated otitis group, epithelial integrity was well preserved and histological findings of inflammation were significantly decreased compared to the saline, penicillin G and alpha-lipoic acid treated otitis groups. The most favourable oxidative parameters were observed in the control group, followed by the alpha-lipoic acid plus penicillin G treated otitis group.
  
  
  CONCLUSIONS
  Alpha-lipoic acid, with its antioxidant, anti-inflammatory and tissue protective properties, may decrease the clinical sequelae and morbidity associated with acute otitis media.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery,Ataturk University Medical Faculty,Erzurum,Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Tatar
authors.affiliation: Department of Otolaryngology,Head and Neck Surgery,Ordu University Medical Faculty,Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Korkmaz
authors.affiliation: Department of Pharmacology,Ataturk University Medical Faculty,Erzurum,Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Yayla
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery,Ataturk University Medical Faculty,Erzurum,Turkey.
authors.forename: M S
authors.initials: MS
authors.lastname: Gozeler
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery,Ataturk University Medical Faculty,Erzurum,Turkey.
authors.forename: V
authors.initials: V
authors.lastname: Mutlu
authors.affiliation: Department of Pharmacology,Ataturk University Medical Faculty,Erzurum,Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Halici
authors.affiliation: Department of Microbiology,Ataturk University Medical Faculty,Erzurum,Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Uslu
authors.affiliation: Department of Otolaryngology,Head and Neck Surgery,Ordu University Medical Faculty,Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Korkmaz
authors.affiliation: Department of Embryology and Histology,Ataturk University Medical Faculty,Erzurum,Turkey.
authors.forename: J
authors.initials: J
authors.lastname: Selli
mesh_terms: D000208:Acute Disease; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D008315:Malondialdehyde / Q000378:metabolism; D009092:Mucous Membrane / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010033:Otitis Media; D010400:Penicillin G / Q000494:pharmacology*; D011008:Pneumococcal Infections; D013296:Streptococcus pneumoniae; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism; D008063:Thioctic Acid / Q000494:pharmacology*; D014432:Tympanic Membrane / Q000187:drug effects* / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D008315:Malondialdehyde; D008063:Thioctic Acid; D013482:Superoxide Dismutase; D005978:Glutathione; D010400:Penicillin G
keywords: Alpha-Lipoic Acid; Guinea Pig; Inflammation; Otitis Media; Reactive Oxygen Species