title: [Immunomorphology of oral lichen planus].
abstract: The article is devoted to immunohistochemical study of reticular and erosive forms of oral lichen planus. Morphological examination of the reticular form revealed the increased number of Langerhans cells (CD1a), mast cells (CD25) and T lymphocytes (CD4, CD8, CD16) in the oral epithelium. Activation of these cells leads to the secretion of TNF-α and destruction of basal keratinocytes, which manifests as a focal reduction of intercellular protein expression of E-cadherin. Destruction of basal keratinocytes in a reticular form of oral lichen planus is accompanied by a significant decrease in proliferative activity of the basal cell layer (21.7±10.2%) compared with normal mucosa (33.6±7.0%), p=0.0045. In erosive form along with the above changes IgG and C3d complement's elements are revealed, which confirms the activation of immune complex mechanisms in the erosion area.
authors.affiliation: Central Research Institute of Dentistry and Maxillofacial Surgery, Ministry of Health of Russian Federation, Moscow, Russia.
authors.forename: O F
authors.initials: OF
authors.lastname: Rabinovich
authors.affiliation: Peoples' Friendship University of Russia, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Ivina
authors.affiliation: Central Research Institute of Dentistry and Maxillofacial Surgery, Ministry of Health of Russian Federation, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Guseva
authors.affiliation: Peoples' Friendship University of Russia, Moscow, Russia.
authors.forename: I I
authors.initials: II
authors.lastname: Babichenko
mesh_terms: D015820:Cadherins / Q000276:immunology; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000473:pathology; D007801:Langerhans Cells / Q000276:immunology / Q000473:pathology; D017676:Lichen Planus, Oral / Q000276:immunology* / Q000473:pathology*; D008297:Male; D008407:Mast Cells / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D015820:Cadherins; D014409:Tumor Necrosis Factor-alpha