title: Can targeting glutamate receptors with long-term heat acclimation improve outcomes following hypoxic injury?
abstract: Long-term heat acclimation appears to improve tolerance to hypoxic insults in various tissues, including brain, providing a promising avenue to improve functional outcomes following cerebrovascular events. Glutamate discharge is implicated in dysfunction following hypoxic stress and thus, targeting glutamate receptors with heat acclimation could improve cognitive outcomes following hypoxic injury.
authors.affiliation: Department of Human Physiology; University of Oregon ; Eugene, OR USA.
authors.forename: Brett R
authors.initials: BR
authors.lastname: Ely
authors.affiliation: Department of Human Physiology; University of Oregon ; Eugene, OR USA.
authors.forename: Vienna E
authors.initials: VE
authors.lastname: Brunt
authors.affiliation: Department of Human Physiology; University of Oregon ; Eugene, OR USA.
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Minson
keywords: NMDA; brain; concussion; cross-tolerance; stroke