title: Nanoparticles and direct immunosuppression.
abstract: Targeting the immune system with nanomaterials is an intensely active area of research. Specifically, the capability to induce immunosuppression is a promising complement for drug delivery and regenerative medicine therapies. Many novel strategies for immunosuppression rely on nanoparticles as delivery vehicles for small-molecule immunosuppressive compounds. As a consequence, efforts in understanding the mechanisms in which nanoparticles directly interact with the immune system have been overshadowed. The immunological activity of nanoparticles is dependent on the physiochemical properties of the nanoparticles and its subsequent cellular internalization. As the underlying factors for these reactions are elucidated, more nanoparticles may be engineered and evaluated for inducing immunosuppression and complementing immunosuppressive drugs. This review will briefly summarize the state-of-the-art and developments in understanding how nanoparticles induce immunosuppressive responses, compare the inherent properties of nanomaterials which induce these immunological reactions, and comment on the potential for using nanomaterials to modulate and control the immune system.
authors.affiliation: Joint Department of Biomedical Engineering, North Carolina State University and University of North Carolina, Chapel Hill, Raleigh, NC 27695, USA.
authors.forename: Terrika A
authors.initials: TA
authors.lastname: Ngobili
authors.affiliation: Joint Department of Biomedical Engineering, North Carolina State University and University of North Carolina, Chapel Hill, Raleigh, NC 27695, USA Department of Electrical & Computer Engineering, North Carolina State University, Raleigh, NC 27695, USA mdaniel6@ncsu.edu.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Daniele
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000378:metabolism*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D053758:Nanoparticles / Q000378:metabolism*
chemical_list: D004337:Drug Carriers; D007166:Immunosuppressive Agents
keywords: Nanoparticles; anti-inflammatory; bionanoscience; immunosuppression; immunotoxicity; nanotoxicology