title: Early and Thorough Wound Debridement Is Crucial for Treatment of Patients With Thermal Burns and para-Chloronitrobenzene Poisoning.
abstract: para-Chloronitrobenzene (p-CNB) is one of the important chemicals with high liposolubility and oxidizing properties. Heated p-CNB liquid can cause thermal injury by absorption over skin and wound and even methemoglobinemia by conversion of hemoglobin into methemoglobin. Severe methemoglobinemia is a life-threatening condition that demands immediate treatment. It is very rare for individuals to be injured by heated p-CNB, but they should be carefully attended to because of the peculiarities of this kind of injury. In the past 10 years, we received 5 patients who were injured by heated p-CNB. In addition to the intravenous administration of methylene blue, prompt and thorough wound management played a crucial role in the treatment of these critically ill patients, indicating the potential value of sufficient information for the clinical practitioners. The purpose of this article is to report our experience in the management of patients with thermal burns and p-CNB poisoning.
authors.affiliation: Zhejiang Quhua Hospital, Quzhou, China.
authors.forename: Yuanhai
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
authors.forename: Xingang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Zhejiang Quhua Hospital, Quzhou, China.
authors.forename: Liangfang
authors.initials: L
authors.lastname: Ni
authors.affiliation: Zhejiang Quhua Hospital, Quzhou, China.
authors.forename: Chunjiang
authors.initials: C
authors.lastname: Ye
authors.affiliation: Zhejiang Quhua Hospital, Quzhou, China.
authors.forename: Jianfen
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
authors.forename: Chunmao
authors.initials: C
authors.lastname: Han
authors.affiliation: Second Affiliated Hospital of Zhejiang University, Hangzhou, China yuch1969@gmail.com.
authors.forename: Chaoheng
authors.initials: C
authors.lastname: Yu
mesh_terms: D000328:Adult; D002057:Burns, Chemical / Q000150:complications / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D016638:Critical Illness / Q000628:therapy; D003646:Debridement / Q000379:methods*; D019468:Disease Management; D061345:Early Medical Intervention / Q000379:methods; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008708:Methemoglobinemia / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008751:Methylene Blue / Q000008:administration & dosage*; D008875:Middle Aged; D009578:Nitrobenzenes / Q000009:adverse effects / Q000378:metabolism; D012883:Skin Ulcer / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D004791:Enzyme Inhibitors; D009578:Nitrobenzenes; C032785:2-chloronitrobenzene; D008751:Methylene Blue
keywords: chemical burns; methemoglobinemia; para-chloronitrobenzene; wound debridement