title: Serum Chemerin Levels Are Associated with Abdominal Visceral Fat in Type 2 Diabetes.
abstract: Chemerin is a recently identified adipokine suggested to play a role in obesity and its metabolic complications. The relationship between visceral obesity and serum chemerin levels in type 2 diabetes (T2DM) is unknown and may differ from that of subjects without diabetes. Therefore, we evaluated whether serum chemerin was associated with visceral abdominal obesity in patients with T2DM. A total of 218 Korean patients with T2DM were enrolled and metabolic parameters, abdominal visceral and subcutaneous fat areas, and serum chemerin levels were measured. Serum chemerin level showed positive correlation with fasting insulin, HOMA-IR, serum triglyceride, serum creatinine, urine albumin/creatinine ratio, high-sensitivity C-reactive protein (hsCRP), fibrinogen, abdominal visceral fat area, visceral to subcutaneous fat area ratio, and negatively correlation with high density lipoprotein cholesterol and creatinine clearance (CCr) after adjusting for age, gender and body mass index. Multiple linear stepwise regression analysis showed that abdominal visceral fat area (β = 0.001, P < 0.001), serum triglyceride (β = 0.001, P < 0.001), CCr (β = -0.003, P = 0.001), hsCRP (β = 0.157, P = 0.001), fibrinogen (β = 0.001, P < 0.001) and BMI (β = 0.02, P = 0.008) independently affected log transformed serum chemerin levels. Higher serum chemerin level was associated with higher level of abdominal visceral fat area, serum triglyceride, hsCRP and fibrinogen and lower level of CCr in patients with T2DM. Serum chemerin may be used as a biomarker of visceral adiposity and chemerin may play a role in inflammation, decreased renal function, and increased cardiovascular risk in T2DM.
authors.affiliation: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea .
authors.forename: Juyoung
authors.identifier: 0000-0002-3764-178X
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea .
authors.forename: So Hun
authors.identifier: 0000-0002-2554-3664
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Biomedical Sciences, College of Medicine, Inha University, Incheon, Korea .
authors.forename: Young Ju
authors.identifier: 0000-0002-6816-8067
authors.initials: YJ
authors.lastname: Suh
authors.affiliation: Center for Clinical Research, Inha University School of Medicine, Incheon, Korea .
authors.forename: Hyun Ae
authors.identifier: 0000-0002-0163-0376
authors.initials: HA
authors.lastname: Lim
authors.affiliation: Center for Clinical Research, Inha University School of Medicine, Incheon, Korea .
authors.forename: Heekyoung
authors.identifier: 0000-0002-1355-5705
authors.initials: H
authors.lastname: Shin
authors.affiliation: Department of Radiology, Inha University School of Medicine, Incheon, Korea .
authors.forename: Soon Gu
authors.identifier: 0000-0002-6635-4595
authors.initials: SG
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea .
authors.forename: Chei Won
authors.initials: CW
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea .
authors.forename: Seung Youn
authors.identifier: 0000-0001-6797-6858
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Center for Clinical Research, Inha University School of Medicine, Incheon, Korea .
authors.forename: Dae Hyung
authors.identifier: 0000-0002-0284-0519
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea .
authors.forename: Seongbin
authors.identifier: 0000-0002-8189-395X
authors.initials: S
authors.lastname: Hong
authors.affiliation: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea .
authors.forename: Yong Seong
authors.identifier: 0000-0001-7579-2530
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea .
authors.forename: Moon-Suk
authors.identifier: 0000-0003-1756-8498
authors.initials: MS
authors.lastname: Nam
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D018925:Chemokines / Q000097:blood*; D003404:Creatinine / Q000097:blood / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D050152:Intra-Abdominal Fat / Q000473:pathology*; D016014:Linear Models; D054834:Lipocalins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D018925:Chemokines; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D054834:Lipocalins; C478630:RARRES2 protein, human; D014280:Triglycerides; D002097:C-Reactive Protein; D003404:Creatinine
keywords: Abdominal Visceral Fat; Chemerin; Type 2 Diabetes Mellitus