title: Fabrication of Silica-Coated Hollow Carbon Nanospheres Encapsulating Fe3O4 Cluster for Magnetical and MR Imaging Guided NIR Light Triggering Hyperthermia and Ultrasound Imaging.
abstract: Iron oxide nanoparticles (IONPs)-carbon (C) hybrid zero-dimensional nanostructures normally can be categorized into core-shell and yolk-shell architectures. Although IONP-C is a promising theranostic nanoagent, the in vivo study has surprisingly been less described. In addition, little effort has strived toward the fabrication of yolk-shell compared to the core-shell structures. In this context, we synthesized a yolk-shell type of the silica-coated hollow carbon nanospheres encapsulating IONPs cluster, which can be dispersed in aqueous solution for systemic studies in vivo, via the preparation involving the mixed micellization, polymerization/hollowing, sol-gel (hydration-condensation), and pyrolysis processes. Through a surface modification of the polyethylenimine followed by the sol-gel process, the silica shell coating was able to escape from condensing and sintering courses resulting in aggregation, due to the annealing. Not limited to the well-known functionalities in magnetical targeting and magnetic resonance (MR) imaging for IONP-C hybrid structures, we expanded this yolk-shell NPs as a near-infrared (NIR) light-responsive echogenic nanoagent giving an enhanced ultrasound imaging. Overall, we fabricated the NIR sensitive yolk-shell IONP-C to activate ultrasound imaging and photothermal ablation under magnetically and MR imaging guided therapy.
authors.affiliation: Department of Chemistry and Advanced Optoelectronic Technology Center, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Yun-Kai
authors.initials: YK
authors.lastname: Huang
authors.affiliation: Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital , Kaohsiung 833, Taiwan.
authors.forename: Chia-Hao
authors.initials: CH
authors.lastname: Su
authors.affiliation: Department of Chemistry and Advanced Optoelectronic Technology Center, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Jiu-Jeng
authors.initials: JJ
authors.lastname: Chen
authors.affiliation: Department of Chemistry and Advanced Optoelectronic Technology Center, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Chun-Ting
authors.initials: CT
authors.lastname: Chang
authors.affiliation: Department of Chemistry and Advanced Optoelectronic Technology Center, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Yu-Hsin
authors.initials: YH
authors.lastname: Tsai
authors.affiliation: Department of Chemistry and Advanced Optoelectronic Technology Center, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Sheng-Fu
authors.initials: SF
authors.lastname: Syu
authors.affiliation: Department of Chemistry and Advanced Optoelectronic Technology Center, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Tsu-Ting
authors.initials: TT
authors.lastname: Tseng
authors.affiliation: Department of Chemistry and Advanced Optoelectronic Technology Center, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Chen-Sheng
authors.initials: CS
authors.lastname: Yeh
mesh_terms: D002244:Carbon / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D005334:Fever; D007259:Infrared Rays; D008279:Magnetic Resonance Imaging / Q000379:methods*; D054118:Nanospheres / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D014463:Ultrasonography / Q000379:methods*
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D002244:Carbon; D012822:Silicon Dioxide
keywords: carbon; magnetism; near-infrared; ultrasound; yolk−shell