title: Cardiovascular risk after androgen deprivation therapy for prostate cancer: an Asian perspective.
abstract: Androgen deprivation therapy (ADT) plays an important role in managing prostate cancer. However, ADT may result in major cardiovascular events and potentially lead to fatal consequences. Cardiovascular disease is the leading cause of mortality and it is a very important health condition to look into. Asians and Caucasians differ both physiologically and genetically, and they may have display different cardiovascular profiles. In this article, we reviewed the literature focusing on the cardiovascular risk after ADT for prostate cancer in the Asian population. We would discuss about the pathogenesis of ADT leading to cardiovascular events, summarize the findings concerning cardiac and stroke risks after ADT, compare between the different modalities of ADT and also provide genetic basics which are unique to Asians. We hope this article would provide more insights into the cardiovascular risk after ADT for prostate cancer in an Asian perspective.
authors.affiliation: SH Ho Urology Centre, Division of Urology, Department of Surgery, 4/F LCW Clinical Science Building, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China.
authors.forename: Jeremy Yuen Chun
authors.initials: JY
authors.lastname: Teoh
authors.affiliation: SH Ho Urology Centre, Division of Urology, Department of Surgery, 4/F LCW Clinical Science Building, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China. ngcf@surgery.cuhk.edu.hk.
authors.forename: Chi-Fai
authors.initials: CF
authors.lastname: Ng
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use*; D044466:Asian People / Q000235:genetics; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000208:ethnology*; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000628:therapy*; D018570:Risk Assessment; D020521:Stroke / Q000208:ethnology*; D044465:White People / Q000235:genetics
chemical_list: D000726:Androgen Antagonists; D007987:Gonadotropin-Releasing Hormone
keywords: Androgen deprivation therapy; Asian; Cardiovascular; Myocardial infarction; Prostate cancer; Stroke