title: Primary Cutaneous Lymphomas in Children and Adolescents.
abstract: Primary cutaneous lymphomas are rare in children and mostly represented by mycosis fungoides and CD30(+) lymphoproliferative disorders. Most pediatric cutaneous lymphomas have similar clinical/pathological features as their adult counterparts, particularly the T-cell subtypes. With regard to outcome, adult cutaneous mature T-cell lymphomas have a tendency to progression, while this appears to be relatively infrequent in children. The outcome of cutaneous B-cell lymphomas depends on subtype, with the B-lymphoblastic entity being associated with similar outcomes to precursor B acute lymphoblastic leukemia, while there are insufficient data on other entities. The diagnosis and treatment of these patients require a close collaboration between experienced pediatric pathologists, dermatologists, and oncologists. Prospective collection of longitudinal clinical and biological data from children with these rare lymphomas is needed to better understand their biological and clinical behavior and to ultimately discover the best therapeutic strategies.
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, Hospital for Sick Children, Ontario, Toronto, Canada.
authors.forename: Francesco
authors.initials: F
authors.lastname: Ceppi
authors.affiliation: Division of Dermatology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Elena
authors.initials: E
authors.lastname: Pope
authors.affiliation: Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario.
authors.forename: Bo
authors.initials: B
authors.lastname: Ngan
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, Hospital for Sick Children, Ontario, Toronto, Canada. oussama.abla@sickkids.ca.
authors.forename: Oussama
authors.initials: O
authors.lastname: Abla
mesh_terms: D000293:Adolescent; D002648:Child; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D017731:Lymphomatoid Papulosis / Q000628:therapy; D009182:Mycosis Fungoides / Q000628:therapy*; D011446:Prospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*
keywords: cutaneous NHL; management; pediatric; treatment