title: Spatio-temporal expression of Sox genes in murine palatogenesis.
abstract: Members of the Sox gene family play critical roles in many biological processes including organogenesis. We carried out comparative in situ hybridisation analysis of seventeen Sox genes (Sox1-14, 17, 18 and 21) during murine palatogenesis from initiation to fusion of the palatal shelves above the dorsal side of the tongue. At palatal shelf initiation (E12.5), the localized expression of six Sox genes (Sox2, 5, 6, 9, 12 and 13) was observed in the shelves, whereas Sox4 and Sox11 showed ubiquitious expression. During the down-growth of palatal shelves (E13.5), Sox4, Sox5, and Sox9 exhibited restricted expression to the interior side of the palatal shelves facing the tongue. Following elevation of the palatal shelves (E14.5), Sox2, Sox11 and Sox21 expression was present in the midline epithelial seam. We thus identify dynamic spatio-temporal expression of Sox gene family during the process of palatogenesis.
authors.affiliation: Division of Oral Anatomy, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan; Division of Oral and Maxillofacial Surgery, Department of Health Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Momoko
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: Division of Oral Anatomy, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan; Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, Guy's Hospital, London Bridge, London, SE1 9RT, UK; Oral Life Science, Research Center for Advanced Oral Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Katsushige
authors.initials: K
authors.lastname: Kawasaki
authors.affiliation: Division of Oral Anatomy, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan; Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, Guy's Hospital, London Bridge, London, SE1 9RT, UK.
authors.forename: Maiko
authors.initials: M
authors.lastname: Kawasaki
authors.affiliation: Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, Guy's Hospital, London Bridge, London, SE1 9RT, UK.
authors.forename: Thantrira
authors.initials: T
authors.lastname: Portaveetus
authors.affiliation: Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, Guy's Hospital, London Bridge, London, SE1 9RT, UK.
authors.forename: Shelly
authors.initials: S
authors.lastname: Oommen
authors.affiliation: Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, Guy's Hospital, London Bridge, London, SE1 9RT, UK.
authors.forename: James
authors.initials: J
authors.lastname: Blackburn
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Health Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nagai
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Health Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kitamura
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Health Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nishikawa
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Health Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Kodama
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Health Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Ritsuo
authors.initials: R
authors.lastname: Takagi
authors.affiliation: Division of Oral Anatomy, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Takeyasu
authors.initials: T
authors.lastname: Maeda
authors.affiliation: Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, Guy's Hospital, London Bridge, London, SE1 9RT, UK.
authors.forename: Paul T
authors.initials: PT
authors.lastname: Sharpe
authors.affiliation: Division of Oral Anatomy, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan; Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, Guy's Hospital, London Bridge, London, SE1 9RT, UK. Electronic address: atsushiohazama@dent.niigata-u.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ohazama
mesh_terms: D000818:Animals; D004847:Epithelial Cells / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D051379:Mice; D005810:Multigene Family / Q000235:genetics; D038081:Organogenesis / Q000235:genetics*; D010159:Palate / Q000254:growth & development / Q000378:metabolism*; D055747:SOX Transcription Factors / Q000096:biosynthesis; D055748:SOXB1 Transcription Factors / Q000096:biosynthesis*; D055749:SOXB2 Transcription Factors / Q000096:biosynthesis*; D055751:SOXC Transcription Factors / Q000096:biosynthesis*
chemical_list: D055747:SOX Transcription Factors; D055748:SOXB1 Transcription Factors; D055749:SOXB2 Transcription Factors; D055751:SOXC Transcription Factors; C490793:Sox11 protein, mouse; C527783:Sox2 protein, mouse; C484489:Sox21 protein, mouse
keywords: In situ hybridisation; Palatal development; Sox