title: Intestinal-type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment.
abstract: Sinonasal intestinal-type adenocarcinomas (ITACs) are epithelial tumors of the nasal cavity and the paranasal sinuses, often related to professional exposure to organic dust, mainly wood or leather. It is a rare cancer. If resectable, surgery is the treatment of choice. Postoperative radiotherapy is often indicated to increase local control. Systemic treatment (chemotherapy, targeted agents, or immunotherapy) of irresectable ITACs and/or metastasized disease is less standardized.
  
  
  
  Articles on ITAC histopathology, molecular profile, and current treatment options of this specific tumor were identified and reviewed, using the electronic databases Pubmed, Medline, Cochrane, and Web of Science.
  
  
  
  This article reviews what is currently known on the histopathology, tumorigenesis, molecular characteristics, and standardized treatment options of ITAC.
  
  
  
  More translational research is needed to identify druggable targets that may lead to a personalized treatment plan in order to improve long-term outcome in patients with locally advanced and/or metastasized ITAC. © 2016 Wiley Periodicals, Inc. Head Neck 38: First-1570, 2016.
authors.affiliation: Division of Medical Oncology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands. ann.hoeben@mumc.nl.
authors.forename: Ann
authors.initials: A
authors.lastname: Hoeben
authors.affiliation: Division of Medical Oncology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Linda
authors.initials: L
authors.lastname: van de Winkel
authors.affiliation: Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Frank
authors.initials: F
authors.lastname: Hoebers
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Kross
authors.affiliation: Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Chantal
authors.initials: C
authors.lastname: Driessen
authors.affiliation: Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: Pieter
authors.initials: P
authors.lastname: Slootweg
authors.affiliation: Division of Medical Oncology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Vivianne C G
authors.initials: VC
authors.lastname: Tjan-Heijnen
authors.affiliation: Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Carla
authors.initials: C
authors.lastname: van Herpen
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000473:pathology / Q000628:therapy; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm; D004391:Dust; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009154:Mutation; D009669:Nose Neoplasms / Q000209:etiology / Q000473:pathology / Q000628:therapy; D010255:Paranasal Sinus Neoplasms / Q000209:etiology / Q000473:pathology / Q000628:therapy; D011379:Prognosis
chemical_list: D004273:DNA, Neoplasm; D004391:Dust
keywords: gene expression; intestinal-type adenocarcinoma; pathology; sinonasal adenocarcinoma; treatment