title: Roles of RNA-binding Proteins and Post-transcriptional Regulation in Driving Male Germ Cell Development in the Mouse.
abstract: Tissue development and homeostasis are dependent on highly regulated gene expression programs in which cell-specific combinations of regulatory factors determine which genes are expressed and the post-transcriptional fate of the resulting RNA transcripts. Post-transcriptional regulation of gene expression by RNA-binding proteins has critical roles in tissue development-allowing individual genes to generate multiple RNA and protein products, and the timing, location, and abundance of protein synthesis to be finely controlled. Extensive post-transcriptional regulation occurs during mammalian gametogenesis, including high levels of alternative mRNA expression, stage-specific expression of mRNA variants, broad translational repression, and stage-specific activation of mRNA translation. In this chapter, an overview of the roles of RNA-binding proteins and the importance of post-transcriptional regulation in male germ cell development in the mouse is presented.
authors.affiliation: Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH, 44106, USA. ddl33@case.edu.
authors.forename: Donny D
authors.initials: DD
authors.lastname: Licatalosi
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000166:cytology*; D006801:Humans; D008297:Male; D008540:Meiosis; D051379:Mice; D014176:Protein Biosynthesis; D012313:RNA / Q000235:genetics* / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000502:physiology*; D012708:Sertoli Cells / Q000502:physiology; D013045:Species Specificity; D013091:Spermatogenesis / Q000502:physiology*; D013737:Testis / Q000196:embryology
chemical_list: D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D012313:RNA
keywords: Alternative mRNA processing; Gametogenesis; Polyadenylation; Post-transcriptional regulation; RNA-binding proteins; Splicing; Translational control