title: Autoinflammation and HLA-B27: Beyond Antigen Presentation.
abstract: HLA-B27 associated disorders comprise a group of inflammatory conditions which have in common an association with the HLA class I molecule, HLA-B27. Given this association, these diseases are classically considered disorders of adaptive immunity. However, mounting data are challenging this assumption and confirming that innate immunity plays a more prominent role in pathogenesis than previously suspected. In this review, the concept of autoinflammation is discussed and evidence is presented from human and animal models to support a key role for innate immunity in HLA-B27 associated disorders.
authors.affiliation: a Department of Medicine, Division of Arthritis & Rheumatic Diseases , Oregon Health & Science University , Portland , Oregon , USA.
authors.forename: Cailin H
authors.initials: CH
authors.lastname: Sibley
mesh_terms: D017951:Antigen Presentation / Q000276:immunology*; D015796:HLA-B27 Antigen / Q000097:blood*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D025241:Spondylarthritis / Q000276:immunology*; D014606:Uveitis, Anterior / Q000276:immunology*
chemical_list: D015796:HLA-B27 Antigen
keywords: Autoinflammation; HLA-B27; IL-1; innate; spondyloarthritis