title: Association of Serum Uric Acid With Cardiometabolic Risk Factors and Metabolic Syndrome in Iranian Adolescents: the CASPIAN-III Study.
abstract: BACKGROUND
  There is controversial evidence on association of serum acid uric (SUA) with cardiometabolic risk factors and metabolic syndrome in adults. This study aimed to investigate the associations of SUA levels, components of metabolic syndrome, and other cardiometabolic risk factors, in a nationally representative sample of Iranian adolescents.
  
  
  METHODS
  This study included 132 participants who met the criteria of metabolic syndrome and 235 participants without metabolic syndrome. The participants were grouped according to the tertiles of SUA. Metabolic syndrome was defined according to the Adult Treatment Panel III criteria modified for children and adolescents. The relationship between SUA and cardiometabolic risk factors and metabolic syndrome was assessed by multivariable logistic regression analysis.
  
  
  RESULTS
  The mean age of the participants was 15.21 ± 2.35 years, with no significant difference between the boys and the girls. The participants whose SUA was categorized in the 2nd tertile and those falling into the 3rd tertile had significantly higher systolic blood pressure (P < .001) as compared with the lower tertile(s). A similar trend was documented for the overall high blood pressure. Metabolic syndrome was associated with the 2nd and 3rd tertiles of SUA as compared to the lower tertile(s), in the adjusted model (P < .001), with the risk increasing by at least 2 times.
  
  
  CONCLUSIONS
  Our study showed that those adolescents with metabolic syndrome had higher SUA levels. Its association with some components of metabolic syndrome supports that SUA might be an additional component of metabolic syndrome even during adolescence.
authors.forename: Saeid
authors.initials: S
authors.lastname: Safiri
authors.forename: Mostafa
authors.initials: M
authors.lastname: Qorbani
authors.forename: Ramin
authors.initials: R
authors.lastname: Heshmat
authors.forename: Ramin
authors.initials: R
authors.lastname: Tajbakhsh
authors.forename: Amir
authors.initials: A
authors.lastname: Eslami Shahr Babaki
authors.forename: Shirin
authors.initials: S
authors.lastname: Djalalinia
authors.forename: Mohammad Esmaeil
authors.initials: ME
authors.lastname: Motlagh
authors.forename: Mohammad Hasan
authors.initials: MH
authors.lastname: Tajadini
authors.forename: Hamid
authors.initials: H
authors.lastname: Asayesh
authors.forename: Omid
authors.initials: O
authors.lastname: Safari
authors.affiliation: Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. kelishadi@med.mui.ac.ir.
authors.forename: Roya
authors.initials: R
authors.lastname: Kelishadi
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology; D050356:Lipid Metabolism / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D063766:Pediatric Obesity / Q000097:blood / Q000150:complications; D012307:Risk Factors; D012959:Socioeconomic Factors; D014527:Uric Acid / Q000378:metabolism*
chemical_list: D014527:Uric Acid