title: Late recurrence of breast carcinoma metastasis to the hypopharynx: a case report.
abstract: BACKGROUND
  We report a rare case of a patient with a hypopharyngeal metastasis from breast cancer.
  
  
  METHODS
  Isolated breast cancer metastasis to the hypopharynx has been previously reported in only one autopsy case. Herein, we report a 56-year-old woman with metastases to the hypopharynx almost 24 years after receiving a mastectomy and chemotherapy to treat primary breast carcinoma. We believe that she is the first patient to be treated for metastatic breast carcinoma to the hypopharynx. The hypopharyngeal tumor reduced in size after administration of an oral aromatase inhibitor. The patient has remained alive with a preserved larynx for three years.
  
  
  CONCLUSIONS
  Breast cancer metastasis to the hypopharynx is an extremely rare event.
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Shizuoka, 431-3192 Japan.
authors.forename: Chisako
authors.initials: C
authors.lastname: Izumi
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Shizuoka, 431-3192 Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Misawa
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Shizuoka, 431-3192 Japan.
authors.forename: Shiori
authors.initials: S
authors.lastname: Endo
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Shizuoka, 431-3192 Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sugiyama
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Shizuoka, 431-3192 Japan.
authors.forename: Daiki
authors.initials: D
authors.lastname: Mochizuki
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Shizuoka, 431-3192 Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Imai
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Shizuoka, 431-3192 Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Mima
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Shizuoka, 431-3192 Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Misawa
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Shizuoka, 431-3192 Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamatodani
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Shizuoka, 431-3192 Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mineta
keywords: Aromatase inhibitor; Breast carcinoma metastasis; E-cadherin; Hypopharynx; VEGFR2