title: The Regulation of GluN2A by Endogenous and Exogenous Regulators in the Central Nervous System.
abstract: The NMDA receptor is the most widely studied ionotropic glutamate receptor, and it is central to many physiological and pathophysiological processes in the central nervous system. GluN2A is one of the two main types of GluN2 NMDA receptor subunits in the forebrain. The proper activity of GluN2A is important to brain function, as the abnormal regulation of GluN2A may induce some neuropsychiatric disorders. This review will examine the regulation of GluN2A by endogenous and exogenous regulators in the central nervous system.
authors.affiliation: Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, People's Republic of China.|Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, People's Republic of China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, People's Republic of China.
authors.forename: Liying
authors.initials: L
authors.lastname: Zhan
authors.affiliation: North China Pharmaceutical Group New Drug Research and Development Co., Ltd, Shijiazhuang, 050015, People's Republic of China.
authors.forename: Xiaokun
authors.initials: X
authors.lastname: Cheng
authors.affiliation: Department of Pathophysiology, Hebei Medical University, Shijiazhuang, 050017, People's Republic of China.
authors.forename: Linan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Nursing, Hebei Medical University, Shijiazhuang, 050017, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, 050018, People's Republic of China. yjs0622@163.com.|Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, People's Republic of China. yjs0622@163.com.|State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang, 050018, People's Republic of China. yjs0622@163.com.
authors.forename: Zibin
authors.initials: Z
authors.lastname: Gao
mesh_terms: D000818:Animals; D001519:Behavior; D002490:Central Nervous System / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate
keywords: Endogenous regulators; Exogenous regulators; GluN2A; Regulation