title: Ethnicity is an independent predictor of IVF-ICSI outcome: a study of 5,549 cycles in Spain and India.
abstract: OBJECTIVE
  To determine the role of ethnicity on IVF/ICSI outcomes between Indian and white Caucasian women.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  White Caucasian and Indian women undergoing IVF/ICSI treatment cycles. Total 5549 self, non-donor, fresh IVF cycles conducted from January 2014 to March 2015, out of which, 4227 were white Caucasian and 1322 were Indian. Data were collected on baseline characteristics, IVF cycle parameters and outcomes. Ongoing pregnancy rate (OPR) was measured as main outcome.
  
  
  RESULTS
  Indian women differed significantly from white Caucasian women in baseline characteristics like age (30.6 ± 0.2 versus 37.6 ± 0.1 years; p < 0.001), BMI (22.3 ± 0.2 versus 26.6 ± 1.0 kg/m2; p < 0.05), duration of infertility (6.9 ± 3.0 versus 2.5 ± 0.1 years; p < 0.001) and antral follicle count (AFC) (8.9 ± 0.4 versus 7.5 ± 0.2; p < 0.001). Indian women had lower implantation rate (30.1% versus 39.6%: p < 0.001) and OPR (35.1% versus 41.7%: p < 0.001) compared with white Caucasian women. Regression analysis proved independent effect of ethnicity on OPR (OR 0.944; 95% CI 0.928-0.961: p < 0.001) Conclusions: OPR was significantly lower among Indian ethnic group following IVF/ICSI suggest that ethnicity, like age, is a major and an independent predictor of IVF outcome.
authors.affiliation: a Department of Reproductive Medicine , NIF (Nova IVI Fertility) Clinic , Ahmedabad , India and.
authors.forename: Azadeh P
authors.initials: AP
authors.lastname: Patel
authors.affiliation: a Department of Reproductive Medicine , NIF (Nova IVI Fertility) Clinic , Ahmedabad , India and.
authors.forename: Jayesh A
authors.initials: JA
authors.lastname: Patel
authors.affiliation: b Department of Reproductive Medicine , IVI (Instituto Valenciano de Infertilidad) , Madrid , Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Cruz
authors.affiliation: a Department of Reproductive Medicine , NIF (Nova IVI Fertility) Clinic , Ahmedabad , India and.
authors.forename: Arati
authors.initials: A
authors.lastname: Gupte-Shah
authors.affiliation: b Department of Reproductive Medicine , IVI (Instituto Valenciano de Infertilidad) , Madrid , Spain.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Garcia Velasco
authors.affiliation: a Department of Reproductive Medicine , NIF (Nova IVI Fertility) Clinic , Ahmedabad , India and.
authors.forename: Manish R
authors.initials: MR
authors.lastname: Banker
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D006801:Humans; D007194:India / Q000208:ethnology; D007247:Infertility, Female / Q000208:ethnology*; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D011247:Pregnancy; D012189:Retrospective Studies; D013030:Spain / Q000208:ethnology; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data; D044465:White People / Q000208:ethnology
keywords: Ethnicity; ICSI; Indian; in vitro fertilization; white caucasian