title: E3 Ubiquitin ligase RNF126 regulates the progression of tongue cancer.
abstract: This study aims to analyze the role of RNF126 in the oncogenesis of tongue cancer. The cell proliferation and viability of human tongue cancer cells, SCC25 and SCC9 cells, were determined by cell counting and MTT assay, respectively. The effect of RNF126 on regulating AKT signaling pathway was analyzed through western blotting. The transplantation tumor model of nude mice was used to evaluate the tumorigenecity of RNF126. Knockdown of RNF126 inhibited the proliferation and viability of SCC9 and SCC25 cells. Inhibition of RNF126 also decreased the activity of AKT1 as well as its downstream molecules. Furthermore, RNF126 regulated the tumor volume on mice model. These data suggested that RNF126 might be related to the progression of tongue cancer through regulating AKT signaling pathway.
authors.affiliation: Department of Endodontics, College of Stomatology, Dalian Medical University, Dalian, 116044, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Wang
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430072, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Endodontics, College of Stomatology, Dalian Medical University, Dalian, 116044, China.
authors.forename: Yuehan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Endodontics, College of Stomatology, Dalian Medical University, Dalian, 116044, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Niu
authors.affiliation: Department of Endodontics, College of Stomatology, Dalian Medical University, Dalian, 116044, China.
authors.forename: Guowu
authors.initials: G
authors.lastname: Ma
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430072, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yin
authors.affiliation: Department of Endodontics, College of Stomatology, Dalian Medical University, Dalian, 116044, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Shi
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D004195:Disease Models, Animal; D018450:Disease Progression; D055785:Gene Knockdown Techniques; D064593:Heterografts; D006801:Humans; D008297:Male; D051379:Mice; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D015398:Signal Transduction; D014062:Tongue Neoplasms / Q000378:metabolism* / Q000473:pathology*; D047368:Tumor Burden; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C578829:RNF126 protein, human; D044767:Ubiquitin-Protein Ligases; D051057:Proto-Oncogene Proteins c-akt
keywords: Cell proliferation; E3 ubiquitin ligase; RNF126; tongue cancer; tumor burden