title: Enteric glial cells have specific immunosuppressive properties.
abstract: Enteric glial cells (EGC) have trophic and neuroregulatory functions in the enteric nervous system, but whether they exert a direct effect on immune cells is unknown. Here, we used co-cultures to show that human EGC can inhibit the proliferation of activated T lymphocytes. Interestingly, EGC from Crohn's patients were effective at one EGC for two T cells whereas EGC from control patients required a ratio of 1:1. These data suggest that EGC contribute to local immune homeostasis in the gastrointestinal wall. They also raise the possibility that EGC have particular immunosuppressive properties in inflammatory bowel diseases such as Crohn's disease.
authors.affiliation: INSERM, UMR 913, Nantes F-44035, France; Université de Nantes, Faculté de Médecine, Nantes F-44035, France; CHU de Nantes, Institut des Maladies de l'Appareil Digestif, IMAD, Nantes F-44093, France.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Kermarrec
authors.affiliation: INSERM, UMR 913, Nantes F-44035, France; Université de Nantes, Faculté de Médecine, Nantes F-44035, France; CHU de Nantes, Institut des Maladies de l'Appareil Digestif, IMAD, Nantes F-44093, France.
authors.forename: Tony
authors.initials: T
authors.lastname: Durand
authors.affiliation: INSERM, UMR 913, Nantes F-44035, France; Université de Nantes, Faculté de Médecine, Nantes F-44035, France; CHU de Nantes, Institut des Maladies de l'Appareil Digestif, IMAD, Nantes F-44093, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Neunlist
authors.affiliation: INSERM, UMR 913, Nantes F-44035, France; Université de Nantes, Faculté de Médecine, Nantes F-44035, France; CHU de Nantes, Institut des Maladies de l'Appareil Digestif, IMAD, Nantes F-44093, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Naveilhan
authors.affiliation: INSERM, UMR 913, Nantes F-44035, France; Université de Nantes, Faculté de Médecine, Nantes F-44035, France; CHU de Nantes, Institut des Maladies de l'Appareil Digestif, IMAD, Nantes F-44093, France. Electronic address: isabelle.neveu@univ-nantes.fr.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Neveu
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects* / Q000502:physiology; D002478:Cells, Cultured; D018920:Coculture Techniques; D003424:Crohn Disease / Q000473:pathology; D017077:Culture Media, Conditioned / Q000494:pharmacology; D017615:Enteric Nervous System / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007414:Intestinal Neoplasms / Q000473:pathology; D008213:Lymphocyte Activation / Q000502:physiology; D009457:Neuroglia / Q000737:chemistry / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology*
chemical_list: D015703:Antigens, CD; D017077:Culture Media, Conditioned; D005904:Glial Fibrillary Acidic Protein; D007166:Immunosuppressive Agents
keywords: Enteric glial cells; Immunoregulation; Inflammatory bowel diseases; T cell