title: The Role of Cell-Penetrating Peptide and Transferrin on Enhanced Delivery of Drug to Brain.
abstract: The challenge of effectively delivering therapeutic agents to brain has led to an entire field of active research devoted to overcome the blood brain barrier (BBB) and efficiently deliver drugs to brain. This review focusses on exploring the facets of a novel platform designed for the delivery of drugs to brain. The platform was constructed based on the hypothesis that a combination of receptor-targeting agent, like transferrin protein, and a cell-penetrating peptide (CPP) will enhance the delivery of associated therapeutic cargo across the BBB. The combination of these two agents in a delivery vehicle has shown significantly improved (p < 0.05) translocation of small molecules and genes into brain as compared to the vehicle with only receptor-targeting agents. The comprehensive details of the uptake mechanisms and properties of various CPPs are illustrated here. The application of this technology, in conjunction with nanotechnology, can potentially open new horizons for the treatment of central nervous system disorders.
authors.affiliation: Department of Pharmaceutical Sciences, College of Health Professions, North Dakota State University, Fargo, ND 58105, USA. gitanjali.sharma@ndsu.edu.
authors.forename: Gitanjali
authors.initials: G
authors.lastname: Sharma
authors.affiliation: Department of Pharmaceutical Sciences, College of Health Professions, North Dakota State University, Fargo, ND 58105, USA. sushant.lakkadwala@ndsu.edu.
authors.forename: Sushant
authors.initials: S
authors.lastname: Lakkadwala
authors.affiliation: Department of Neuroscience, Tufts University School of Medicine, 136 Harrison avenue, Boston, MA 02111, USA. amit.modgil@tufts.edu.
authors.forename: Amit
authors.initials: A
authors.lastname: Modgil
authors.affiliation: Department of Pharmaceutical Sciences, College of Health Professions, North Dakota State University, Fargo, ND 58105, USA. jagdish.singh@ndsu.edu.
authors.forename: Jagdish
authors.initials: J
authors.lastname: Singh
mesh_terms: D001812:Blood-Brain Barrier / Q000737:chemistry; D002463:Cell Membrane Permeability; D057846:Cell-Penetrating Peptides / Q000737:chemistry / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems / Q000379:methods*; D011990:Receptors, Transferrin / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism*
chemical_list: D057846:Cell-Penetrating Peptides; D011990:Receptors, Transferrin; D014168:Transferrin
keywords: blood brain barrier (BBB); cell-penetrating peptide (CPPs); functionalization; liposomes; transferrin