title: Review of Cohort Studies for Mood Disorders.
abstract: This paper aimed to review currently available cohort studies of subjects with mood disorders such as major depressive disorder (MDD) and bipolar disorder (BD). Using the PubMed and KoreaMed databases, we reviewed eight major cohort studies. Most studies recruited participants with MDD and BD separately, so direct comparison of factors associated with diagnostic changes was difficult. Regular and frequent follow-up evaluations utilizing objective mood ratings and standardized evaluation methods in a naturalistic fashion are necessary to determine detailed clinical courses of mood disorders. Further, biological samples should also be collected to incorporate clinical findings in the development of new diagnostic and therapeutic approaches. An innovative cohort study that can serve as a platform for translational research for treatment and prevention of mood disorders is critical in determining clinical, psychosocial, neurobiological and genetic factors associated with long-term courses and consequences of mood disorders in Korean patients.
authors.affiliation: Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Health Sciences & Technology, Department of Clinical Research Design and Evaluation, and Department of Medical Device Management and Research, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Seoul, Republic of Korea.; Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Hong Jin
authors.initials: HJ
authors.lastname: Jeon
authors.affiliation: Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Baek
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Ahn
authors.affiliation: Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Se Joo
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Seoul National University Bundang Hospital, College of Medicine, Seoul National University, Seoul, Republic of Korea.
authors.forename: Tae Hyun
authors.initials: TH
authors.lastname: Ha
authors.affiliation: Department of Psychiatry, Gyeongsang National University College of Medicine, Jinju, Republic of Korea.
authors.forename: Boseok
authors.initials: B
authors.lastname: Cha
authors.affiliation: Department of Psychiatry, Pusan National University School of Medicine, Busan, Republic of Korea.
authors.forename: Eunsoo
authors.initials: E
authors.lastname: Moon
authors.affiliation: Department of Psychiatry, Chonnam National University College of Medicine, Gwangju, Republic of Korea.
authors.forename: Hee-Ju
authors.initials: HJ
authors.lastname: Kang
authors.affiliation: Department of Psychiatry, Seoul National Hospital, Seoul, Republic of Korea.
authors.forename: Vin
authors.initials: V
authors.lastname: Ryu
authors.affiliation: Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Chul-Hyun
authors.initials: CH
authors.lastname: Cho
authors.affiliation: Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Jung-Yoon
authors.initials: JY
authors.lastname: Heo
authors.affiliation: Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Kiwon
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Heon-Jeong
authors.initials: HJ
authors.lastname: Lee
keywords: Bipolar disorder; Cohort study; Major depressive disorder; Mood disorder; Review