title: Treatment of severe refractory erythema nodosum leprosum with tumor necrosis factor inhibitor Etanercept.
abstract: Erythema nodosum leprosum (ENL) is a common complication of lepromatous leprosy. Some patients unresponsive to conventional, first-line therapeutics develop recurrent, recalcitrant ENL. Here, we report a case of severe refractory ENL that was successfully treated with Etanercept. Biologics may be considered as therapeutic alternatives in management of severe, recalcitrant ENL.
authors.affiliation: Department of Dermatology, Venereology, and Leprology, ESI-Postgraduate Institute of Medical Sciences and Research, New Delhi, India.
authors.forename: Sundeep
authors.initials: S
authors.lastname: Chowdhry
authors.affiliation: Department of Dermatology, Venereology, and Leprology, ESI-Postgraduate Institute of Medical Sciences and Research, New Delhi, India. Electronic address: drakhilesh89@gmail.com.
authors.forename: Akhilesh
authors.initials: A
authors.lastname: Shukla
authors.affiliation: Department of Dermatology, Venereology, and Leprology, ESI-Postgraduate Institute of Medical Sciences and Research, New Delhi, India.
authors.forename: Paschal
authors.initials: P
authors.lastname: D'souza
authors.affiliation: Department of Dermatology, Venereology, and Leprology, ESI-Postgraduate Institute of Medical Sciences and Research, New Delhi, India.
authors.forename: Tapan
authors.initials: T
authors.lastname: Dhali
authors.affiliation: Department of Dermatology, Venereology, and Leprology, ESI-Postgraduate Institute of Medical Sciences and Research, New Delhi, India.
authors.forename: Prashansa
authors.initials: P
authors.lastname: Jaiswal
mesh_terms: D004893:Erythema Nodosum / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D000068800:Etanercept / Q000008:administration & dosage*; D006801:Humans; D007918:Leprosy / Q000150:complications*; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D014409:Tumor Necrosis Factor-alpha; D000068800:Etanercept
keywords: Biologics; Erythema nodosum leprosum; Etanercept; Leprosy; Treatment