title: Effect of ultra-fast mild hypothermia using total liquid ventilation on hemodynamics and respiratory mechanics.
abstract: Ultra-fast cooling for mild therapeutic hypothermia (MTH) has several potential applications, including prevention of post-cardiac arrest syndrome. Ultra-fast MTH by total liquid ventilation (TLV) entails the sudden filling of the lungs with a cold perfluorocarbon liquid and its subsequent use to perform TLV. The present physiological study was aimed at assessing whether pulmonary and systemic hemodynamics as well as lung mechanics are significantly altered during this procedure. Pulmonary and systemic arterial pressures, cardiac output as well as airway resistance and respiratory system compliance were measured during ultra-fast MTH by TLV followed by rewarming and normothermia in six healthy juvenile lambs. Results show that none of the studied variables were altered upon varying the perfluorocarbon temperature from 12 to 41 °C. It is concluded that ultra-fast MTH by TLV does not have any deleterious effect on hemodynamics or lung mechanics in healthy juvenile lambs.
authors.affiliation: Department of Pediatrics, Université de Sherbrooke, J1H 5N4, QC, Canada.
authors.forename: Michaël
authors.initials: M
authors.lastname: Sage
authors.affiliation: Department of Mechanical Engineering, Université de Sherbrooke, J1K 2R1, QC, Canada.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Nadeau
authors.affiliation: Inserm, U955, Equipe 3, Créteil, 94000, France; Université Paris Est, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France.
authors.forename: Matthias
authors.initials: M
authors.lastname: Kohlhauer
authors.affiliation: Department of Pediatrics, Université de Sherbrooke, J1H 5N4, QC, Canada. Electronic address: jean-paul.praud@usherbrooke.ca.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Praud
authors.affiliation: Inserm, U955, Equipe 3, Créteil, 94000, France; Université Paris Est, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: Tissier
authors.affiliation: Department of Mechanical Engineering, Université de Sherbrooke, J1K 2R1, QC, Canada.
authors.forename: Raymond
authors.initials: R
authors.lastname: Robert
authors.affiliation: Department of Pediatrics, Université de Sherbrooke, J1H 5N4, QC, Canada; Hôpital d'enfant Armand Trousseau, Groupe Hospitalier Universitaire Est Parisien, Université Pierre et Marie Curie, Paris 6, Paris, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Walti
authors.affiliation: Department of Mechanical Engineering, Université de Sherbrooke, J1K 2R1, QC, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Micheau
mesh_terms: D000818:Animals; D005466:Fluorocarbons / Q000494:pharmacology; D006439:Hemodynamics / Q000502:physiology*; D007036:Hypothermia, Induced / Q000379:methods*; D021061:Liquid Ventilation / Q000379:methods*; D015656:Respiratory Mechanics / Q000502:physiology*; D012756:Sheep; D034561:Sheep, Domestic
chemical_list: D005466:Fluorocarbons
keywords: Airway resistance; Cardiac output; Pulmonary arterial pressure; Respiratory system compliance; Systemic arterial pressure