title: Arterial Spin Labeling and Blood Oxygen Level-Dependent MRI Cerebrovascular Reactivity in Cerebrovascular Disease: A Systematic Review and Meta-Analysis.
abstract: The cerebrovascular reactivity (CVR) results of blood oxygen level-dependent (BOLD) and arterial spin labeling (ASL) MRI studies performed in patients with cerebrovascular disease (steno-occlusive vascular disease or stroke) were systematically reviewed.
  
  
  
  Thirty-one articles were included. Twenty-three (74.2%) studies used BOLD MRI to evaluate the CVR, 4 (12.9%) studies used ASL MRI and 4 (12.9%) studies used both BOLD and ASL MRI. Thirteen studies (3 significant) found a lower BOLD CVR, 2 studies found a similar CVR and 3 studies found a higher CVR in the ipsilateral compared to the contralateral hemisphere. Nine (5 significant) out of 10 studies found a lower BOLD CVR in the ipsilateral hemispheres of patients compared to controls. Six studies (2 significant) found a lower ASL CVR in the ipsilateral compared to the contralateral hemispheres. Three out of 5 studies found a significant lower ASL CVR in the ipsilateral hemispheres of patients compared to controls.
  
  
  
  This review brings support for a reduced BOLD and ASL CVR in the ipsilateral hemisphere of patients with cerebrovascular disease. We suggest that future studies will be performed in a uniform way so reference values can be established and could be used to guide treatment decisions in patients with cerebrovascular disease.
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Diederik P J
authors.initials: DP
authors.lastname: Smeeing
authors.forename: Jeroen
authors.initials: J
authors.lastname: Hendrikse
authors.forename: Esben T
authors.initials: ET
authors.lastname: Petersen
authors.forename: Manus J
authors.initials: MJ
authors.lastname: Donahue
authors.forename: Jill B
authors.initials: JB
authors.lastname: de Vis
mesh_terms: D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D016009:Chi-Square Distribution; D004734:Energy Metabolism; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D055420:Perfusion Imaging / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D013113:Spin Labels; D014664:Vasodilation
chemical_list: D015415:Biomarkers; D013113:Spin Labels; D010100:Oxygen