title: Small clonal B-cell population in the bone marrow as a possible tool in the diagnosis of occult primary parotid lymphoma.
abstract: METHODS
  An 82-years old Hispanic woman with a past medical history significant for pulmonary thromboembolism on oral anticoagulation, rheumatoid arthritis, and hypertension developed a new onset thrombocytopenia.
  
  
  RESULTS
  Small clonal B-cells populations (SCBP) also known as monoclonal B-cell lymphocytosis was found as part of the workup for an idiopathic thrombocytopenia and lead ultimately to the diagnosis of parotid primary follicular lymphoma coexisting with Warthin tumor involving the bone marrow in a small extent and oncocytic papilloma located in the maxillary sinus.
  
  
  RESULTS
  Patient was treated with Rituximab monotherapy with improvement on her platelet count.
  
  
  CONCLUSIONS
  Although it is unclear the role of this clonal cells, they may work as a possible diagnostic tool for occult lymphomas. Further prospective studies are needed to confirm this possible association.
authors.affiliation: Department of Pathology. Fundación Santa Fe de Bogotá, Bogotá, Colombia.
authors.forename: Martha
authors.initials: M
authors.lastname: Romero
authors.affiliation: Division of Hemato-Oncology. Clínica Rey David, Cali, Colombia.
authors.forename: Guido R
authors.initials: GR
authors.lastname: González-Fontal
authors.affiliation: Hematology. Fundación Santa Fe de Bogotá, Bogotá, Colombia.
authors.forename: Mónica
authors.initials: M
authors.lastname: Duarte
authors.affiliation: Department of Pathology. Fundación Santa Fe de Bogotá, Bogotá, Colombia.
authors.forename: Carlos
authors.initials: C
authors.lastname: Saavedra
authors.affiliation: Division of Infectious Diseases, University of Colorado Denver, USA.
authors.forename: Andrés F
authors.initials: AF
authors.lastname: Henao-Martínez
mesh_terms: D000369:Aged, 80 and over; D001402:B-Lymphocytes / Q000473:pathology*; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000473:pathology*; D002999:Clone Cells / Q000473:pathology; D005260:Female; D006801:Humans; D008218:Lymphocytosis / Q000000981:diagnostic imaging / Q000473:pathology*; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000473:pathology*; D009382:Neoplasms, Unknown Primary / Q000000981:diagnostic imaging / Q000473:pathology*; D010307:Parotid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D000072078:Positron Emission Tomography Computed Tomography; D013921:Thrombocytopenia / Q000000981:diagnostic imaging / Q000473:pathology*
keywords: B-lymphocytes; bone marrow; diagnosis; lymphoma; parotid gland