title: Bladder Preservation Therapy: A Review of the Literature and Future Directions.
abstract: Trimodal bladder preservation therapy (ie, transurethral resection followed by chemoradiotherapy) may be an acceptable treatment alternative to radical cystectomy with urinary diversion in the carefully selected patient with muscle invasive bladder cancer. Although no head-to-head randomized controlled trials have been performed, large retrospective cohort reviews and observational data analyses suggest comparable oncologic outcomes in select patients with the additional benefit of maximizing quality of life and maintaining the patient's native bladder. In this review, we discuss the evolution and clinical outcomes of bladder preservation therapy, highlighting its role in the contemporary management of muscle invasive bladder cancer.
authors.affiliation: Department of Urology, Einstein Healthcare Network, Philadelphia, PA. Electronic address: dbcahn@gmail.com.
authors.forename: David B
authors.initials: DB
authors.lastname: Cahn
authors.affiliation: Department of Surgical Oncology, Division of Urologic Oncology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA.
authors.forename: Benjamin T
authors.initials: BT
authors.lastname: Ristau
authors.affiliation: Department of Urology, Einstein Healthcare Network, Philadelphia, PA.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Ghiraldi
authors.affiliation: Department of Radiation Oncology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Churilla
authors.affiliation: Department of Hematology/Oncology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Geynisman
authors.affiliation: Department of Radiation Oncology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Horwitz
authors.affiliation: Department of Urology, Einstein Healthcare Network, Philadelphia, PA; Department of Surgical Oncology, Division of Urologic Oncology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Uzzo
authors.affiliation: Department of Surgical Oncology, Division of Urologic Oncology, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA.
authors.forename: Marc C
authors.initials: MC
authors.lastname: Smaldone
mesh_terms: D059248:Chemoradiotherapy / Q000639:trends; D015653:Cystectomy / Q000639:trends; D005544:Forecasting; D006801:Humans; D059351:Organ Sparing Treatments / Q000639:trends; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000628:therapy*