title: Simple animal models for amyotrophic lateral sclerosis drug discovery.
abstract: BACKGROUND
  Simple animal models have enabled great progress in uncovering the disease mechanisms of amyotrophic lateral sclerosis (ALS) and are helping in the selection of therapeutic compounds through chemical genetic approaches.
  
  
  METHODS
  Within this article, the authors provide a concise overview of simple model organisms, C. elegans, Drosophila and zebrafish, which have been employed to study ALS and discuss their value to ALS drug discovery. In particular, the authors focus on innovative chemical screens that have established simple organisms as important models for ALS drug discovery.
  
  
  CONCLUSIONS
  There are several advantages of using simple animal model organisms to accelerate drug discovery for ALS. It is the authors' particular belief that the amenability of simple animal models to various genetic manipulations, the availability of a wide range of transgenic strains for labelling motoneurons and other cell types, combined with live imaging and chemical screens should allow for new detailed studies elucidating early pathological processes in ALS and subsequent drug and target discovery.
authors.affiliation: a INRS-Institut Armand-Frappier , Laval , Canada.
authors.forename: Shunmoogum A
authors.initials: SA
authors.lastname: Patten
authors.affiliation: b Department of Neuroscience , FRQS Groupe de recherche sur le système nerveux central and CRCHUM, University of Montréal , Montréal , Canada.
authors.forename: J Alex
authors.initials: JA
authors.lastname: Parker
authors.affiliation: c Department of Medicine & Physiology , University of Toronto , Toronto , Canada.|d Zebrafish Centre for Advanced Drug Discovery , St. Michael's Hospital , Toronto , Canada.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Wen
authors.affiliation: b Department of Neuroscience , FRQS Groupe de recherche sur le système nerveux central and CRCHUM, University of Montréal , Montréal , Canada.|d Zebrafish Centre for Advanced Drug Discovery , St. Michael's Hospital , Toronto , Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Drapeau
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy* / Q000235:genetics; D000818:Animals; D030801:Animals, Genetically Modified; D017173:Caenorhabditis elegans; D004195:Disease Models, Animal; D004330:Drosophila; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D058990:Molecular Targeted Therapy; D015027:Zebrafish
keywords: Amyotrophic lateral sclerosis; C. elegans; Drosophila; chemical genetics; drug discovery; zebrafish