title: Entangled in a membranous web: ER and lipid droplet reorganization during hepatitis C virus infection.
abstract: Hepatitis C virus (HCV) is a major cause of liver disease worldwide. To establish and maintain chronic infection, HCV extensively rearranges cellular organelles to generate distinct compartments for viral RNA replication and virion assembly. Here, we review our current knowledge of how HCV proliferates and remodels ER-derived membranes while preserving and expanding associated lipid droplets during viral infection. Unraveling the molecular mechanisms responsible for HCV-induced membrane reorganization will enhance our understanding of the HCV life-cycle, the associated liver pathology, and the biology of the ER:lipid droplet interface in general.
authors.affiliation: Gladstone Institutes, University of California San Francisco, 1650 Owens Street, San Francisco, CA 94941, United States.
authors.forename: Nathan L
authors.initials: NL
authors.lastname: Meyers
authors.affiliation: Gladstone Institutes, University of California San Francisco, 1650 Owens Street, San Francisco, CA 94941, United States.
authors.forename: Krystal A
authors.initials: KA
authors.lastname: Fontaine
authors.affiliation: Gladstone Institutes, University of California San Francisco, 1650 Owens Street, San Francisco, CA 94941, United States.
authors.forename: G Renuka
authors.initials: GR
authors.lastname: Kumar
authors.affiliation: Gladstone Institutes, University of California San Francisco, 1650 Owens Street, San Francisco, CA 94941, United States. Electronic address: Mott@gladstone.ucsf.edu.
authors.forename: Melanie
authors.initials: M
authors.lastname: Ott
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D016174:Hepacivirus / Q000502:physiology*; D006526:Hepatitis C / Q000378:metabolism* / Q000821:virology*; D006801:Humans; D066292:Lipid Droplets / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism; D014779:Virus Replication
chemical_list: D012367:RNA, Viral