title: Novel anionic polymer as a carrier for CNS delivery of anti-Alzheimer drug.
abstract: Natural and plant-based polymers could be used for control release of drugs and also helps in targeting drug to the site of action. The main objective of present work was to check the feasibility of plant-based, namely, mango gum polymeric nanoparticles (NPs) as a carrier for central nervous system (CNS) delivery using model drug donepezil (DZP). The NPs were prepared by modified ionic gelation method and emulsion cross-linking method. Zeta sizer results showed that the diameter of NPs was about 90-130 nm. The polymeric DZP-loaded NPs were almost spherical in shape, as revealed by transmission electron microscopy (TEM). On increasing concentration of NPs suspension from 50 μg/ml to 5000 μg/ml there was no significant increase in % hemolysis. In vivo studies showed that brain targeting was achieved. So on the basis of above results, the extracted water soluble fraction of mango gum is a suitable candidate for brain delivery in the form of nanoformulations.
authors.affiliation: a Department of Pharmaceutics , JSS College of Pharmacy, Off Campus J.S.S. University , Mysore, Udhagamandalam, Tamil Nadu , India.
authors.forename: Satya Lavanya
authors.initials: SL
authors.lastname: Jakki
authors.affiliation: a Department of Pharmaceutics , JSS College of Pharmacy, Off Campus J.S.S. University , Mysore, Udhagamandalam, Tamil Nadu , India.
authors.forename: Yasam Venkata
authors.initials: YV
authors.lastname: Ramesh
authors.affiliation: a Department of Pharmaceutics , JSS College of Pharmacy, Off Campus J.S.S. University , Mysore, Udhagamandalam, Tamil Nadu , India.
authors.forename: K
authors.initials: K
authors.lastname: Gowthamarajan
authors.affiliation: a Department of Pharmaceutics , JSS College of Pharmacy, Off Campus J.S.S. University , Mysore, Udhagamandalam, Tamil Nadu , India.
authors.forename: V
authors.initials: V
authors.lastname: Senthil
authors.affiliation: b Scientific Writer, Novartis Healthcare Pvt. Ltd , Hyderabad, Andhra Pradesh , India.
authors.forename: Kunal
authors.initials: K
authors.lastname: Jain
authors.affiliation: c Scientific Writer, Indegene Lifesystems Pvt. Ltd , Bengaluru , Karnataka , India , and.
authors.forename: Sumeet
authors.initials: S
authors.lastname: Sood
authors.affiliation: d Head (R&D), United Biotech Pvt. Ltd , Baddi, Himachal Pradesh , India.
authors.forename: Deepa
authors.initials: D
authors.lastname: Pathak
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D000838:Anions / Q000737:chemistry*; D045744:Cell Line, Tumor; D002490:Central Nervous System / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000008:administration & dosage* / Q000737:chemistry*; D000077265:Donepezil; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D004655:Emulsions / Q000008:administration & dosage / Q000737:chemistry; D005782:Gels / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D007189:Indans / Q000008:administration & dosage / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D010316:Particle Size; D010880:Piperidines / Q000008:administration & dosage / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000838:Anions; D002491:Central Nervous System Agents; D004337:Drug Carriers; D004655:Emulsions; D005782:Gels; D007189:Indans; D010880:Piperidines; D011108:Polymers; D000077265:Donepezil
keywords: Biodistribution studies; cytotoxicity; donepezil; plant polymer; targeted delivery