title: Mixed Carcinoma as an Independent Prognostic Factor in Submucosal Invasive Gastric Carcinoma.
abstract: Mixed carcinoma shows a mixture of glandular and signet ring/poorly cohesive cellular histological components and the prognostic significance of each component is not fully understood. This study aimed to investigate the significance of the poorly cohesive cellular histological component as a risk factor for lymph node metastasis and to examine the diagnostic reliability of endoscopic biopsy. Clinicopathologic characteristics of 202 patients who underwent submucosal invasive gastric carcinoma resection with lymph node dissection in 2005-2012 were reviewed. Mixed carcinoma accounted for 27.2% (56/202) of cases. The overall prevalence of lymph node metastasis was 17.3% (35/202). Lymphatic invasion (P < 0.001), family history of carcinoma (P = 0.025), tumor size (P = 0.004), Lauren classification (P = 0.042), and presence of any poorly cohesive cellular histological component (P = 0.021) positively correlated with the lymph node metastasis rate on univariate analysis. Multivariate analyses revealed lymphatic invasion, family history of any carcinoma, and the presence of any poorly cohesive cellular histological component to be significant and independent factors related to lymph node metastasis. Review of preoperative biopsy slides showed that preoperative biopsy demonstrated a sensitivity of 63.6% and a specificity of 100% in detecting the presence of the poorly cohesive cellular histological component, compared with gastrectomy specimens. The presence of any poorly cohesive cellular histological component was an independent risk factor associated with lymph node metastasis in submucosal invasive gastric carcinoma. Endoscopic biopsy had limited value in predicting the presence and proportion of the poorly cohesive cellular histologic component due to the heterogeneity of mixed carcinoma.
authors.affiliation: Department of Pathology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea .
authors.forename: Hyung Kyu
authors.identifier: 0000-0002-5972-3516
authors.initials: HK
authors.lastname: Park
authors.affiliation: Department of Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea .
authors.forename: Kyung-Yung
authors.identifier: 0000-0002-5288-8772
authors.initials: KY
authors.lastname: Lee
authors.affiliation: Department of Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea .
authors.forename: Moon-Won
authors.identifier: 0000-0003-0346-9042
authors.initials: MW
authors.lastname: Yoo
authors.affiliation: Department of Pathology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea .
authors.forename: Tae Sook
authors.identifier: 0000-0002-3602-9257
authors.initials: TS
authors.lastname: Hwang
authors.affiliation: Department of Pathology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea .
authors.forename: Hye Seung
authors.identifier: 0000-0002-3591-9995
authors.initials: HS
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000473:pathology*; D005773:Gastroscopy; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000473:pathology*
keywords: Biopsy; Early Gastric Cancer; Gastrointestinal Endoscopy; Lymph Node Metastasis; Mixed Carcinoma