title: Slippery signaling: Palmitoylation-dependent control of neuronal kinase localization and activity.
abstract: Modification of proteins with the lipid palmitate, a process called palmitoylation, is important for the normal function of neuronal cells. However, most attention has focused on how palmitoylation regulates the targeting and trafficking of neurotransmitter receptors and non-enzymatic scaffold proteins. In this review we discuss recent studies that suggest that palmitoylation also plays additional roles in neurons by controlling the localization, interactions and perhaps even the activity of protein kinases that play key roles in physiological neuronal regulation and in neuropathological processes.
authors.affiliation: a Shriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair) and.
authors.forename: Audrey
authors.initials: A
authors.lastname: Montersino
authors.affiliation: a Shriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair) and.|b Department of Anatomy and Cell Biology , Temple University School of Medicine , Philadelphia , PA , USA.
authors.forename: Gareth M
authors.initials: GM
authors.lastname: Thomas
mesh_terms: D000818:Animals; D006801:Humans; D054878:Lipoylation; D009474:Neurons / Q000201:enzymology*; D011494:Protein Kinases / Q000378:metabolism*; D021381:Protein Transport; D015398:Signal Transduction
chemical_list: D011494:Protein Kinases
keywords: Glutamate receptor; acylation; palmitoylation; phosphorylation; signaling