title: A Lack of Correlation between Brain-Derived Neurotrophic Factor Serum Level and Verbal Memory Performance in Healthy Polish Population.
abstract: Brain derived neurotrophic factor (BDNF) is considered to be connected with memory and learning through the processes of long term synaptic potentiation and synaptic plasticity. The aim of the study was to examine the relationship between precursor BDNF (proBNDF) and mature BDNF (mBDNF) serum levels and performance on Rey Auditory-Verbal Learning Test (RAVLT) in 150 healthy volunteers. In addition, we have verified the relationships between serum concentration of both forms of BDNF and RAVLT with sociodemographic and lifestyle factors.We found no strong evidence for the correlation of proBDNF and mBDNF serum levels with performance on RAVLT in healthy Polish population in early and middle adulthood. We observed the mBDNF serum concentration to be higher in women compared with men. Moreover, we revealed higher mBDNF level to be connected with lower body mass index (BMI). In turn, the results of RAVLT correlated with sociodemographic and lifestyle factors, such as: age, education, gender, BMI and smoking.
authors.affiliation: Institute of Psychology, Kazimierz Wielki University Bydgoszcz, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Wilkosc
authors.affiliation: Department of Psychiatry Nursing, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University Torun, Poland.
authors.forename: Anita
authors.initials: A
authors.lastname: Markowska
authors.affiliation: Institute of Psychology, Kazimierz Wielki University Bydgoszcz, Poland.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Zajac-Lamparska
authors.affiliation: Psychiatry Genetics Unit, Poznan University of Medical Sciences Poznan, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Skibinska
authors.affiliation: Department of Psychiatry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University Torun, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Szalkowska
authors.affiliation: Department of Psychiatry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University Torun, Poland.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Araszkiewicz
mesh_terms: D000293:Adolescent; D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D015992:Body Mass Index; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D012737:Sex Factors; D012959:Socioeconomic Factors; D014706:Verbal Learning / Q000502:physiology*; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: Rey Auditory-Verbal Learning Test (RAVLT); healthy population; serum mBDNF; serum proBDNF; verbal memory