title: Towards a Multifunctional Electrochemical Sensing and Niosome Generation Lab-on-Chip Platform Based on a Plug-and-Play Concept.
abstract: In this paper, we present a new modular lab on a chip design for multimodal neurotransmitter (NT) sensing and niosome generation based on a plug-and-play concept. This architecture is a first step toward an automated platform for an automated modulation of neurotransmitter concentration to understand and/or treat neurodegenerative diseases. A modular approach has been adopted in order to handle measurement or drug delivery or both measurement and drug delivery simultaneously. The system is composed of three fully independent modules: three-channel peristaltic micropumping system, a three-channel potentiostat and a multi-unit microfluidic system composed of pseudo-Y and cross-shape channels containing a miniature electrode array. The system was wirelessly controlled by a computer interface. The system is compact, with all the microfluidic and sensing components packaged in a 5 cm × 4 cm × 4 cm box. Applied to serotonin, a linear calibration curve down to 0.125 mM, with a limit of detection of 31 μ M was collected at unfunctionalized electrodes. Added sensitivity and selectivity was achieved by incorporating functionalized electrodes for dopamine sensing. Electrode functionalization was achieved with gold nanoparticles and using DNA and o-phenylene diamine polymer. The as-configured platform is demonstrated as a central component toward an "intelligent" drug delivery system based on a feedback loop to monitor drug delivery.
authors.affiliation: Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. adnane.kara.1@ulaval.ca.|Department of Chemistry, Faculty of Sciences and Engineering, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. adnane.kara.1@ulaval.ca.
authors.forename: Adnane
authors.initials: A
authors.lastname: Kara
authors.affiliation: Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. camille.rouillard.1@ulaval.ca.|Department of Chemistry, Faculty of Sciences and Engineering, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. camille.rouillard.1@ulaval.ca.|Ophthalmology Department, Faculty of Medecine, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. camille.rouillard.1@ulaval.ca.
authors.forename: Camille
authors.initials: C
authors.lastname: Rouillard
authors.affiliation: Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. jessy.mathault.1@ulaval.ca.
authors.forename: Jessy
authors.initials: J
authors.lastname: Mathault
authors.affiliation: Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. martin.boisvert.4@ulaval.ca.|Department of Chemistry, Faculty of Sciences and Engineering, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. martin.boisvert.4@ulaval.ca.
authors.forename: Martin
authors.initials: M
authors.lastname: Boisvert
authors.affiliation: Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. frederic.tessier.1@ulaval.ca.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Tessier
authors.affiliation: Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. hamza.landari.1@ulaval.ca.
authors.forename: Hamza
authors.initials: H
authors.lastname: Landari
authors.affiliation: Research Center of CHU de Quebec, (Centre Hospitalier Universitaire)-Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. Imene.Melki@crchudequebec.ulaval.ca.
authors.forename: Imene
authors.initials: I
authors.lastname: Melki
authors.affiliation: Centre de Recherche du Centre Hospitalier Universitaire de Qu&#233;bec (CR-CHUQ), Axe M&#233;decine R&#233;g&#233;n&#233;ratrice, Qu&#233;bec City, QC G1L 3L5, Canada. myriam.laprise-pelletier.1@ulaval.ca.|Centre de Recherche sur les Mat&#233;riaux Avanc&#233;s (CERMA), Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. myriam.laprise-pelletier.1@ulaval.ca.|D&#233;partement de G&#233;nie des Mines, de la M&#233;tallurgie et des Mat&#233;riaux, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. myriam.laprise-pelletier.1@ulaval.ca.
authors.forename: Myriam
authors.initials: M
authors.lastname: Laprise-Pelletier
authors.affiliation: Ophthalmology Department, Faculty of Medecine, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. Elodie.Boisselier@fmed.ulaval.ca.
authors.forename: Elodie
authors.initials: E
authors.lastname: Boisselier
authors.affiliation: Centre de Recherche du Centre Hospitalier Universitaire de Qu&#233;bec (CR-CHUQ), Axe M&#233;decine R&#233;g&#233;n&#233;ratrice, Qu&#233;bec City, QC G1L 3L5, Canada. Marc-Andre.Fortin@gmn.ulaval.ca.|Centre de Recherche sur les Mat&#233;riaux Avanc&#233;s (CERMA), Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. Marc-Andre.Fortin@gmn.ulaval.ca.|D&#233;partement de G&#233;nie des Mines, de la M&#233;tallurgie et des Mat&#233;riaux, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. Marc-Andre.Fortin@gmn.ulaval.ca.
authors.forename: Marc-André
authors.initials: MA
authors.lastname: Fortin
authors.affiliation: Research Center of CHU de Quebec, (Centre Hospitalier Universitaire)-Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. Eric.Boilard@crchudequebec.ulaval.ca.
authors.forename: Eric
authors.initials: E
authors.lastname: Boilard
authors.affiliation: Department of Chemistry, Faculty of Sciences and Engineering, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. Jesse.Greener@chm.ulaval.ca.
authors.forename: Jesse
authors.initials: J
authors.lastname: Greener
authors.affiliation: Electrical and Computer Engineering Deptartment, Faculty of Sciences and Engineering, Universit&#233; Laval, Qu&#233;bec City, QC G1V 0A6, Canada. amine.miled@gel.ulaval.ca.
authors.forename: Amine
authors.initials: A
authors.lastname: Miled
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D055664:Electrochemical Techniques / Q000379:methods; D004566:Electrodes; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D044085:Microfluidics / Q000379:methods*; D059015:Wireless Technology
chemical_list: D006046:Gold
keywords: lab-on-chip; modular microfluidics; system integration