title: On-demand drug release of ICG-liposomal wedelolactone combined photothermal therapy for tumor.
abstract: In the study, a new photoresponsive nano drug delivery system was developed by encapsulating indocyanine green into liposomes (ICG-liposomal wedelolactone), which could improve the water solubility and bioavailability of wedelolactone. The hyperthermia, produced by ICG under near-infrared (NIR) light irradiation, promoted wedelolactone release rapidly from the carriers. The release amount of ICG-liposomal wedelolactone under NIR irradiation reached up to 96.74% over 8h, achieving the drug of on-demand release. Moreover, the growth of HepG2 cells was obviously inhibited by ICG-liposomal wedelolactone under NIR, and the early apoptotic rate of HepG2 cells was 33.74%. The tumor inhibition rate was 81% in the mice bearing tumor treated with the drug system. The results proved that ICG-liposomal wedelolactone, as a novel drug delivery system to co-delivery chemotherapeutic agents and photothermal agents, achieved synergetic effect of chemotherapy and photothermotherapy, which will have an enormous potential in future cancer therapy.
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, P.R. China.
authors.forename: Xuwu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, P.R. China.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, P.R. China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, P.R. China.
authors.forename: Bingshuo
authors.initials: B
authors.lastname: Ji
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, P.R. China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, P.R. China.
authors.forename: Meili
authors.initials: M
authors.lastname: Wang
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, P.R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Dai
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, P.R. China; State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, P.R. China. Electronic address: dwgao@ysu.edu.cn.
authors.forename: Dawei
authors.initials: D
authors.lastname: Gao
mesh_terms: D000818:Animals; D065546:Drug Liberation; D006801:Humans; D006979:Hyperthermia, Induced; D007208:Indocyanine Green / Q000008:administration & dosage*; D008081:Liposomes; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D008081:Liposomes; D007208:Indocyanine Green
keywords: Indocyanine green; Liposomes; On-demand release; Photothermal therapy; Wedelolactone