title: Capsaicin-Coated Silver Nanoparticles Inhibit Amyloid Fibril Formation of Serum Albumin.
abstract: We have synthesized capsaicin-coated silver nanoparticles (AgNPs(Cap)) and have tested their anti-amyloid activity, considering serum albumin (BSA) as a model protein. We found that amyloid formation of BSA was strongly suppressed in the presence of AgNPs(Cap). However, isolated capsaicin and uncapped control nanoparticles did not show such an inhibition effect. Bioinformatics analysis reveals CH-π and H-bonding interactions between capsaicin and BSA in the formation of the protein-ligand complex. These results suggest the significance of surface functionalization of nanoparticles with capsaicin, which probably allows capsaicin to effectively interact with the key residues of the amyloidogenic core of BSA.
authors.affiliation: Center for Biologically Inspired Systems Science, Department of Biology, Indian Institute of Technology Jodhpur , Old Residency Road, Jodhpur, Rajasthan, India 342011.
authors.forename: Bibin G
authors.initials: BG
authors.lastname: Anand
authors.affiliation: Center for Biologically Inspired Systems Science, Department of Biology, Indian Institute of Technology Jodhpur , Old Residency Road, Jodhpur, Rajasthan, India 342011.
authors.forename: Kriti
authors.initials: K
authors.lastname: Dubey
authors.affiliation: Center for Biologically Inspired Systems Science, Department of Biology, Indian Institute of Technology Jodhpur , Old Residency Road, Jodhpur, Rajasthan, India 342011.
authors.forename: Dolat Singh
authors.initials: DS
authors.lastname: Shekhawat
authors.affiliation: Center for Biologically Inspired Systems Science, Department of Biology, Indian Institute of Technology Jodhpur , Old Residency Road, Jodhpur, Rajasthan, India 342011.
authors.forename: Karunakar
authors.initials: K
authors.lastname: Kar
mesh_terms: D000682:Amyloid / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D000982:Antipruritics / Q000494:pharmacology; D002211:Capsaicin / Q000494:pharmacology*; D002417:Cattle; D053768:Metal Nanoparticles / Q000737:chemistry*; D008958:Models, Molecular; D010316:Particle Size; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D012834:Silver / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000682:Amyloid; D000982:Antipruritics; D012710:Serum Albumin, Bovine; D012834:Silver; D002211:Capsaicin