title: Genomic resources and draft assemblies of the human and porcine varieties of scabies mites, Sarcoptes scabiei var. hominis and var. suis.
abstract: The scabies mite, Sarcoptes scabiei, is a parasitic arachnid and cause of the infectious skin disease scabies in humans and mange in other animal species. Scabies infections are a major health problem, particularly in remote Indigenous communities in Australia, where secondary group A streptococcal and Staphylococcus aureus infections of scabies sores are thought to drive the high rate of rheumatic heart disease and chronic kidney disease.
  
  
  
  We sequenced the genome of two samples of Sarcoptes scabiei var. hominis obtained from unrelated patients with crusted scabies located in different parts of northern Australia using the Illumina HiSeq. We also sequenced samples of Sarcoptes scabiei var. suis from a pig model. Because of the small size of the scabies mite, these data are derived from pools of thousands of mites and are metagenomic, including host and microbiome DNA. We performed cleaning and de novo assembly and present Sarcoptes scabiei var. hominis and var. suis draft reference genomes. We have constructed a preliminary annotation of this reference comprising 13,226 putative coding sequences based on sequence similarity to known proteins.
  
  
  
  We have developed extensive genomic resources for the scabies mite, including reference genomes and a preliminary annotation.
authors.affiliation: Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.|Department of Medical Biology, University of Melbourne, Melbourne, VIC, 3010, Australia.
authors.forename: Ehtesham
authors.initials: E
authors.lastname: Mofiz
authors.affiliation: Menzies School of Health Research, Charles Darwin University, Casuarina, NT, 0811, Australia.
authors.forename: Deborah C
authors.initials: DC
authors.lastname: Holt
authors.affiliation: Victorian Life Sciences Computation Initiative, University of Melbourne, Melbourne, VIC, 3010, Australia.
authors.forename: Torsten
authors.initials: T
authors.lastname: Seemann
authors.affiliation: Menzies School of Health Research, Charles Darwin University, Casuarina, NT, 0811, Australia.
authors.forename: Bart J
authors.initials: BJ
authors.lastname: Currie
authors.affiliation: QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD, 4006, Australia.
authors.forename: Katja
authors.initials: K
authors.lastname: Fischer
authors.affiliation: Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. papenfuss@wehi.edu.au.|Department of Medical Biology, University of Melbourne, Melbourne, VIC, 3010, Australia. papenfuss@wehi.edu.au.|Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, 3010, Australia. papenfuss@wehi.edu.au.|Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia. papenfuss@wehi.edu.au.
authors.forename: Anthony T
authors.initials: AT
authors.lastname: Papenfuss
mesh_terms: D000818:Animals; D001315:Australia; D016678:Genome; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D056186:Metagenomics / Q000379:methods; D064307:Microbiota; D012520:Sarcoptes scabiei / Q000145:classification* / Q000235:genetics; D012532:Scabies / Q000662:veterinary*; D017422:Sequence Analysis, DNA / Q000379:methods*; D013552:Swine / Q000382:microbiology / Q000469:parasitology; D013553:Swine Diseases / Q000469:parasitology
keywords: Indigenous Australian health; Sarcoptes scabiei var. hominis; Sarcoptes scabiei var. suis; Scabies mite