title: Clinical importance of bilateral disease in patients with papillary thyroid cancer.
abstract: A cancer-related factor that is not included in papillary thyroid cancer (PTC) prognostic scoring systems is bilaterality. While it may seem that bilaterality should be considered during the management of PTC, its clinical importance has been debated. This controversy exists because the extent of surgery for PTC has not been found to affect survival in low-risk individuals, despite their potential for PTC bilaterality. We sought to determine if PTC bilaterality is a cancer prognosticator based upon its association with known clinical and pathological PTC prognosticators, and MACIS scores. In this article we discuss our findings and their potential clinical implications.
authors.affiliation: From the Department of Surgery, St. Paul's Hospital and University of British Columbia, Vancouver, BC (Moore, Melck, Wiseman); the Michael Smith Genome Sciences Centre, British Columbia Cancer Research Centre, Vancouver, BC (Kasaian, Jones); and the Department of Medical Genetics, University of British Columbia, Vancouver, BC (Jones).
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Moore
authors.affiliation: From the Department of Surgery, St. Paul's Hospital and University of British Columbia, Vancouver, BC (Moore, Melck, Wiseman); the Michael Smith Genome Sciences Centre, British Columbia Cancer Research Centre, Vancouver, BC (Kasaian, Jones); and the Department of Medical Genetics, University of British Columbia, Vancouver, BC (Jones).
authors.forename: Katayoon
authors.initials: K
authors.lastname: Kasaian
authors.affiliation: From the Department of Surgery, St. Paul's Hospital and University of British Columbia, Vancouver, BC (Moore, Melck, Wiseman); the Michael Smith Genome Sciences Centre, British Columbia Cancer Research Centre, Vancouver, BC (Kasaian, Jones); and the Department of Medical Genetics, University of British Columbia, Vancouver, BC (Jones).
authors.forename: Steven
authors.initials: S
authors.lastname: Jones
authors.affiliation: From the Department of Surgery, St. Paul's Hospital and University of British Columbia, Vancouver, BC (Moore, Melck, Wiseman); the Michael Smith Genome Sciences Centre, British Columbia Cancer Research Centre, Vancouver, BC (Kasaian, Jones); and the Department of Medical Genetics, University of British Columbia, Vancouver, BC (Jones).
authors.forename: Adrienne
authors.initials: A
authors.lastname: Melck
authors.affiliation: From the Department of Surgery, St. Paul's Hospital and University of British Columbia, Vancouver, BC (Moore, Melck, Wiseman); the Michael Smith Genome Sciences Centre, British Columbia Cancer Research Centre, Vancouver, BC (Kasaian, Jones); and the Department of Medical Genetics, University of British Columbia, Vancouver, BC (Jones).
authors.forename: Sam M
authors.initials: SM
authors.lastname: Wiseman
mesh_terms: D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D002291:Carcinoma, Papillary; D006801:Humans; D011379:Prognosis; D012189:Retrospective Studies; D000077273:Thyroid Cancer, Papillary; D013961:Thyroid Gland / Q000473:pathology* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy