title: Clinical and Anterior Segment Anatomical Features in Primary Angle Closure Subgroups Based on Configurations of Iris Root Insertion.
abstract: OBJECTIVE
  To compare the clinical and anterior segment anatomical features in primary angle closure sub-groups based on configurations of iris root insertion.
  
  
  METHODS
  Primary angle closure patients were imaged using anterior segment optical coherence tomography. Anterior chamber depth, iris curvature, iris thickness (IT) at the scleral spur and 500, 750, and 1,500 µm from the scleral spur (IT0, IT500, IT750, and IT1500), lens vault, iris area, angle opening distance (AOD500), angle recess area (ARA750), and trabecular iris space area (TISA750) were measured. Iris root insertion was categorized into a non-basal insertion group (NBG) and basal insertion group (BG).
  
  
  RESULTS
  In total, 43 eyes of 39 participants belonged to the NBG and 89 eyes of 53 participants to the BG. The mean age of participants was greater in the NBG than the BG (62.7 ± 5.7 vs. 59.8 ± 7.3 years, p = 0.043), and the baseline intraocular pressure was higher in the BG than the NBG (16.4 ± 4.4 vs. 14.9 ± 3.3 mmHg, p = 0.037). The BG showed a greater IT0 (0.265 ± 0.04 vs. 0.214 ± 0.03 mm, p < 0.001) and iris area (1.59 ± 0.24 vs. 1.52 ± 0.27 mm(2), p = 0.045), lower ARA750 (0.112 ± 0.08 vs. 0.154 ± 0.08 mm(2), p = 0.017) and AOD500 (0.165 ± 0.07 vs. 0.202 ± 0.08 mm, p = 0.014) compared to the NBG.
  
  
  CONCLUSIONS
  The BG had a narrower anterior chamber angle, thicker peripheral iris, and higher pretreatment intraocular pressure.
authors.affiliation: Department of Ophthalmology, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Ji Wook
authors.initials: JW
authors.lastname: Hong
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Sung-Cheol
authors.initials: SC
authors.lastname: Yun
authors.affiliation: Department of Ophthalmology, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Kyung Rim
authors.initials: KR
authors.lastname: Sung
authors.affiliation: Department of Ophthalmology, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jong Eun
authors.initials: JE
authors.lastname: Lee
mesh_terms: D000869:Anterior Eye Segment / Q000000981:diagnostic imaging*; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D032801:Iridectomy / Q000379:methods*; D007498:Iris / Q000000981:diagnostic imaging / Q000601:surgery*; D007908:Lens, Crystalline / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: Anterior segment optical coherence tomography; Anterior segment parameters; Iris root insertion; Primary angle closure