title: Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report.
abstract: Antipsychotic drug treatment can potentially lead to adverse events such as leukopenia and neutropenia. Although these events are rare, they represent serious and life-threatening hematological side effects.
  
  
  
  We present a case study of a patient with schizoaffective disorder in a 50-year-old woman. We report a case of paliperidone extended-release (ER)-induced leukopenia and neutropenia in a female patient with schizoaffective disorder. Initiating lithium carbonate treatment and decreasing the dose of valproic acid improved the observed leukopenia and neutropenia. This treatment did not influence psychotic symptoms.
  
  
  
  The combination of paliperidone ER and valproic acid induces increased paliperidone ER plasma levels. Lithium carbonate was successfully used to treat paliperidone ER-induced leukopenia and neutropenia.
authors.affiliation: Department of Psychiatry, Tenri Hospital, Tenri, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Matsuura
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
authors.forename: Sohei
authors.initials: S
authors.lastname: Kimoto
authors.affiliation: Department of Psychiatry, Tenri Hospital, Tenri, Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Harada
authors.affiliation: Department of Psychiatry, Tenri Hospital, Tenri, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Naemura
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan. muro@naramed-u.ac.jp.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamamuro
authors.affiliation: Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Kishimoto
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced / Q000188:drug therapy*; D016651:Lithium Carbonate / Q000627:therapeutic use*; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy*; D000068882:Paliperidone Palmitate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations; D016651:Lithium Carbonate; D000068882:Paliperidone Palmitate
keywords: Leukopenia; Lithium carbonate; Neutropenia; Paliperidone extended-release; Schizoaffective disorder; Schizophrenia; Valproic acid