title: Diffusion-weighted imaging in pediatric body magnetic resonance imaging.
abstract: Diffusion-weighted MRI is being increasingly used in pediatric body imaging. Its role is still emerging. It is used for detection of tumors and abscesses, differentiation of benign and malignant tumors, and detection of inflamed bowel segments in inflammatory bowel disease in children. It holds great promise in the assessment of therapy response in body tumors, with apparent diffusion coefficient (ADC) value as a potential biomarker. Significant overlap of ADC values of benign and malignant processes and less reproducibility of ADC measurements are hampering its widespread use in clinical practice. With standardization of the technique, diffusion-weighted imaging (DWI) is likely to be used more frequently in clinical practice. We discuss the principles and technique of DWI, selection of b value, qualitative and quantitative assessment, and current status of DWI in evaluation of disease processes in the pediatric body.
authors.affiliation: Department of Diagnostic Imaging, The Hospital for Sick Children, Department of Medical Imaging, University of Toronto, 555 University Ave., Toronto, ON, M5G 1X8, Canada. drgovindchavhan@yahoo.com.
authors.forename: Govind B
authors.initials: GB
authors.lastname: Chavhan
authors.affiliation: Department of Diagnostic Imaging, The Hospital for Sick Children, Department of Medical Imaging, University of Toronto, 555 University Ave., Toronto, ON, M5G 1X8, Canada.
authors.forename: Pablo
authors.initials: P
authors.lastname: Caro-Dominguez
mesh_terms: D000038:Abscess / Q000000981:diagnostic imaging*; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D041981:Gastrointestinal Tract / Q000000981:diagnostic imaging; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000000981:diagnostic imaging*; D008107:Liver Diseases / Q000000981:diagnostic imaging*; D009369:Neoplasms / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014564:Urogenital Abnormalities / Q000000981:diagnostic imaging*; D051598:Whole Body Imaging / Q000379:methods
keywords: Abdomen; Children; Diffusion-weighted imaging; Magnetic resonance imaging; b value