title: Quantitative Nonlinear Contrast-Enhanced Ultrasound of the Breast.
abstract: OBJECTIVE
  Breast cancer is the most frequent type of cancer among women (25% of all cancers). The angiogenic process that fuels the growth of tumors is a potential early indicator for differentiating between malignant and benign tumors. Recently, the use of microbubble-based contrast agents combined with ultrasound has allowed the development of contrast agent-specific imaging modes that provide visualization of tumor neovascularity.
  
  
  CONCLUSIONS
  Contrast-enhanced Doppler, harmonic, and subharmonic imaging are some of the imaging modes that have been investigated for visualizing and quantifying the vascularity in breast tumors.
authors.affiliation: 1 Department of Radiology, Thomas Jefferson University, 7 Main, Ste 763J, 132 S 10th St, Philadelphia, PA 19107.|2 Department of Electrical and Computer Engineering, Drexel University, Philadelphia, PA.
authors.forename: Anush
authors.initials: A
authors.lastname: Sridharan
authors.affiliation: 1 Department of Radiology, Thomas Jefferson University, 7 Main, Ste 763J, 132 S 10th St, Philadelphia, PA 19107.
authors.forename: John R
authors.initials: JR
authors.lastname: Eisenbrey
authors.affiliation: 1 Department of Radiology, Thomas Jefferson University, 7 Main, Ste 763J, 132 S 10th St, Philadelphia, PA 19107.
authors.forename: Jaydev K
authors.initials: JK
authors.lastname: Dave
authors.affiliation: 1 Department of Radiology, Thomas Jefferson University, 7 Main, Ste 763J, 132 S 10th St, Philadelphia, PA 19107.
authors.forename: Flemming
authors.initials: F
authors.lastname: Forsberg
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D005260:Female; D006801:Humans; D045423:Microbubbles; D016217:Ultrasonography, Mammary / Q000379:methods*
chemical_list: D003287:Contrast Media
keywords: breast; microbubble contrast agent; subharmonic imaging; ultrasound