title: Short-term Gains with Long-term Consequences: The Evolving Story of Sepsis Survivorship.
abstract: Sepsis is an acute, life-threatening condition that afflicts millions of patients annually. Advances in care and heightened awareness have led to substantial declines in short-term mortality. An expanding body of literature describes the long-term impact of sepsis, revealing long-term cognitive and functional impairments, sustained inflammation and immune dysfunction, increased healthcare resource use, reduced health-related quality of life, and increased mortality. The evidence challenges the notion that sepsis is an acute, transient illness, revealing rather that sepsis is an acute illness with lingering consequences. This article provides a state-of-the-art review of the emerging literature of the long-term consequences of sepsis.
authors.affiliation: Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Jason H
authors.initials: JH
authors.lastname: Maley
authors.affiliation: Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address: mark.mikkelsen@uphs.upenn.edu.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Mikkelsen
mesh_terms: D006801:Humans; D011788:Quality of Life; D018805:Sepsis; D015996:Survival Rate
keywords: Cognitive impairment; Critical care; Hospital readmission; Infection; Physical impairment; Sepsis