title: Norovirus Infection and Histo-blood Group Antigens in Children Hospitalized with Diarrhea in Lulong and Chenzhou in China.
abstract: Norovirus (NoV) is a pathogen that commonly causes viral diarrhea in children. Studies indicate that NoV recognizes human histo-blood group antigens (HBGAs) as cell attachment factors. In order to explore the correlation between of NoV infection and HBGAs, a cross-sectional study was conducted in children less than five years old who were hospitalized with diarrhea in two areas of China between November 2014 and February 2015. Of the paired stool and saliva samples taken from 424 children, NoV was detected in 24 (6%) children, with viral genotypes GII.3 (n=5), GII.4 (n=14), GII.12 (n=1), and GII.17 (n=4). All of the individuals having NoV infection were either secretors (Lea-b+/Lex-y+) or partial secretors (Lea+b+/Lex+y+) except one GII.3 infection of a non-secretor (Lea+b-/Lex+y-). These results suggest that secretor positive is associated with NoV infection, although non-secretors are not absolutely protected from NoV infection.
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing 102206, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.
authors.forename: Xiao Man
authors.initials: XM
authors.lastname: Sun
authors.affiliation: Center for Disease Control and Prevention of Lulong County, Lulong 066400, Hebei, China.
authors.forename: Xiao Feng3
authors.initials: XF
authors.lastname: Yan
authors.affiliation: Chenzhou No.1 People's Hospital, Chenzhou 423000, Hunan, China.
authors.forename: Zhi Gang
authors.initials: ZG
authors.lastname: He
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing 102206, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.
authors.forename: Jing Xin
authors.initials: JX
authors.lastname: Li
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing 102206, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.
authors.forename: Ni Jun
authors.initials: NJ
authors.lastname: Guo
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing 102206, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.
authors.forename: Zi Qian
authors.initials: ZQ
authors.lastname: Xu
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing 102206, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Jin
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing 102206, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.
authors.forename: Dan Di
authors.initials: DD
authors.lastname: Li
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing 102206, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.
authors.forename: Yong Kang
authors.initials: YK
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing 102206, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.
authors.forename: Guang Cheng
authors.initials: GC
authors.lastname: Xie
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing 102206, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.
authors.forename: Li Li
authors.initials: LL
authors.lastname: Pang
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing 102206, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing 102206, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.affiliation: Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing 102206, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China.
authors.forename: Zhao Jun
authors.initials: ZJ
authors.lastname: Duan
mesh_terms: D001789:Blood Group Antigens / Q000235:genetics*; D017250:Caliciviridae Infections / Q000097:blood* / Q000150:complications* / Q000821:virology; D002675:Child, Preschool; D002681:China; D003430:Cross-Sectional Studies; D003967:Diarrhea / Q000097:blood* / Q000209:etiology* / Q000821:virology; D005243:Feces / Q000821:virology; D005759:Gastroenteritis / Q000097:blood* / Q000821:virology; D005838:Genotype; D006801:Humans; D007223:Infant; D029322:Norovirus / Q000502:physiology*
chemical_list: D001789:Blood Group Antigens