title: [Consortium for detection and management of lung damage induced by bleomycin].
abstract: Bleomycin is a cytotoxic antibiotic and a component of chemotherapy regimens of germ cell tumors and lymphoma. Bleomycin lung injuries occur in 10% of patients, and lead to severe interstitial pneumonia in 3% of patients. Pulmonary toxicity is related to endothelial cells injury induce by free radicals and inflammatory cytokines. Diagnosis of bleomycin-induced lung toxicity is based on the combination of clinical and radiological features, and requires to rule out differential diagnoses including pneumocystis. "Bleomycin-induced pneumonitis" is the most frequent pattern; eosinophilic pneumonitis and organizing pneumonia are rarer. Occurrence of bleomycin lung toxicity requires an immediate and often permanent discontinuation. Treatment is based on steroid. Regular clinical and pulmonary function tests monitoring are mandatory for early detection of bleomycin-induced lung toxicity.
authors.affiliation: CHU de Reims, service des maladies respiratoires et allergiques, 45, rue Cognacq-Jay, 51100 Reims, France.
authors.forename: Josette
authors.initials: J
authors.lastname: Biya
authors.affiliation: Gustave-Roussy, département d'anesthésie-réanimation, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
authors.forename: Annabelle
authors.initials: A
authors.lastname: Stoclin
authors.affiliation: CHU de Reims, service des maladies respiratoires et allergiques, 45, rue Cognacq-Jay, 51100 Reims, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Dury
authors.affiliation: Centre chirurgical Marie-Lannelongue, service de chirurgie thoracique et vasculaire, 133, avenue de la Résistance, 92350 Le Plessis-Robinson, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Le Pavec
authors.affiliation: Gustave-Roussy, département de médecine oncologique, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Mir
authors.affiliation: Gustave-Roussy, département de médecine oncologique, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Lazarovici
authors.affiliation: Gustave-Roussy, département de médecine oncologique, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Fermé
authors.affiliation: Université Paris Descartes, UFR des sciences pharmaceutiques et biologiques, 75270 Paris cedex 06, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Annereau
authors.affiliation: Gustave-Roussy, département d'anesthésie-réanimation, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Ekpe
authors.affiliation: Gustave-Roussy, département des innovations thérapeutiques et des essais précoces, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Massard
authors.affiliation: Gustave-Roussy, département de médecine oncologique, 114, rue Édouard-Vaillant, 94800 Villejuif, France; Université Paris Descartes, UFR des sciences pharmaceutiques et biologiques, 75270 Paris cedex 06, France; Gustave-Roussy, département des innovations thérapeutiques et des essais précoces, 114, rue Édouard-Vaillant, 94800 Villejuif, France. Electronic address: jean-marie.michot@gustaveroussy.fr.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Michot
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects*; D004730:Endothelium, Vascular / Q000187:drug effects; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D011014:Pneumonia / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D011657:Pulmonary Eosinophilia / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D012307:Risk Factors; D028761:Withholding Treatment
chemical_list: D000305:Adrenal Cortex Hormones; D000903:Antibiotics, Antineoplastic; D001761:Bleomycin
keywords: Bleomycin; Bléomycine; Interstitial lung disease; Lung toxicity; Pneumopathie infiltrante diffuse; Toxicité pulmonaire