title: Hemolysis in Preterm Neonates.
abstract: Hemolysis can be an important cause of hyperbilirubinemia in premature and term neonates. It can result from genetic abnormalities intrinsic to or factors exogenous to normal to red blood cells (RBCs). Hemolysis can lead to a relatively rapid increase in total serum/plasma bilirubin, hyperbilirubinemia that is somewhat slow to fall with phototherapy, or hyperbilirubinemia that is likely to rebound after phototherapy. Laboratory methods for diagnosing hemolysis are more difficult to apply, or less conclusive, in preterm infants. Transfusion of donor RBCs can present a bilirubin load that must be metabolized. Genetic causes can be identified by next-generation sequencing panels.
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, Primary Children's Hospital, University of Utah School of Medicine, Chipeta Way, Salt Lake City, UT 84108, USA; Women and Newborn's Clinical Program, Division of Neonatology, Department of Pediatrics, Intermountain Healthcare, University of Utah School of Medicine, Chipeta Way, Salt Lake City, UT 84108, USA. Electronic address: robert.christensen@hsc.utah.edu.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Christensen
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, Primary Children's Hospital, University of Utah School of Medicine, Chipeta Way, Salt Lake City, UT 84108, USA.
authors.forename: Hassan M
authors.initials: HM
authors.lastname: Yaish
mesh_terms: D001663:Bilirubin / Q000378:metabolism*; D001803:Blood Transfusion; D016923:Cell Death; D004912:Erythrocytes; D006461:Hemolysis; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000378:metabolism* / Q000628:therapy; D007231:Infant, Newborn; D007234:Infant, Premature; D010789:Phototherapy
chemical_list: D001663:Bilirubin
keywords: Anemia; Bilirubin; End-tidal carbon monoxide; Haptoglobin; Next-generation DNA sequencing; Prematurity