title: Targeting adipose tissue in the treatment of obesity-associated diabetes.
abstract: Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM). Although several US-approved treatments for obesity and T2DM exist, these are limited by adverse effects and a lack of effective long-term glucose control. In this Review, we provide an overview of the role of adipose tissue in metabolic homeostasis and assess emerging novel therapeutic strategies targeting adipose tissue, including adipokine-based strategies, promotion of white adipose tissue beiging as well as reduction of inflammation and fibrosis.
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Kusminski
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
authors.forename: Perry E
authors.initials: PE
authors.lastname: Bickel
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center.
authors.forename: Philipp E
authors.initials: PE
authors.lastname: Scherer
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy*; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology