title: Toll-Like Receptor 3 is Associated With the Risk of HCV Infection and HBV-Related Diseases.
abstract: There are inconsistent data on the association of risk of hepatitis virus infection and hepatitis virus-related diseases with the toll-like receptor 3 (TLR3) gene.Several common polymorphism sites were targeted to assess the risk of HBV infection, HCV infection, and HBV-related diseases.Meta-analysis combining data for 3547 cases and 2797 controls from 8 studies was performed in this study. Pooled ORs were calculated to measure the risk of hepatitis virus infection and hepatitis virus-related diseases. Fixed-effects pooled ORs were calculated using the Mantel-Haenszel method.The TLR3 gene was associated with a significantly increased risk of HBV-related diseases among 1355 patients and 1130 controls ([pooled OR, [95%CI]: 1.30, [1.15-1.48] for dominant; 1.77, [1.35-2.31] for recessive; 1.28 [1.16-1.41] for allele frequency). Subgroup analyses by a polymorphism site indicated an increased risk of HCV infection in relation to the TT/CT genotypes of rs3775291 (1.50 [1.11-2.01]), and a decreased risk ascribed to the T allele (0.20 [0.16-0.25]). We also noted an association between rs3775291 and significantly increased risk of HBV-related diseases (2.23 [1.55-3.21]). No significant inter-study heterogeneity or publication bias was detected in the analyses.These data suggest a likely effect on the risk to infect HCV and develop HBV-related diseases for the TLR3 gene. Large-scale studies with racially diverse populations are required to validate these findings.
authors.affiliation: From the Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China (PLG, JYH, SL, XTZ); Department of Pharmacology, General Hospital of Beijing Military Region, Beijing, China (LXS); Center of Basic Medical Sciences, Navy General Hospital of PLA Beijing, China (HA); and Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China (JYH, SL).
authors.forename: Pei-Liang
authors.initials: PL
authors.lastname: Geng
authors.forename: Li-Xue
authors.initials: LX
authors.lastname: Song
authors.forename: Huaijie
authors.initials: H
authors.lastname: An
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Huang
authors.forename: Sheng
authors.initials: S
authors.lastname: Li
authors.forename: Xian-Tao
authors.initials: XT
authors.lastname: Zeng
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D005838:Genotype; D006509:Hepatitis B / Q000235:genetics*; D006526:Hepatitis C / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D051196:Toll-Like Receptor 3 / Q000235:genetics*
chemical_list: C495344:TLR3 protein, human; D051196:Toll-Like Receptor 3