title: Systematic Review of Prevalence and Predictors of Frailty in Individuals with Human Immunodeficiency Virus.
abstract: To describe the prevalence and predictors of frailty in individuals with the human immunodeficiency virus (HIV) using systematic review methodology.
  
  
  
  Review.
  
  
  
  Community.
  
  
  
  Older adults with HIV.
  
  
  
  Medline, CINAHL, EMBASE, PsychInfo, and PubMed were searched for original observational studies with populations including individuals with HIV in which frailty was assessed using the frailty phenotype or a variant thereof. Studies were examined for frailty prevalence and predictors of the syndrome in those with HIV.
  
  
  
  Thirteen of 322 citations were included for full review. All demonstrated the presence of frailty in individuals with HIV, with prevalence ranging from 5% to 28.6% depending on population studied. HIV was a risk factor for frailty. Predictors of frailty included older age, comorbidities, diagnosis of acquired immunodeficiency syndrome, and low current CD4(+) cell count.
  
  
  
  HIV appears to be an independent risk factor for frailty, with frailty occurring in individuals with HIV at rates comparable with older individuals without HIV. Heterogeneity in study populations and frailty assessment measures hamper accurate description of the problem. Future longitudinal work with standardized methodology is needed to describe prevalence accurately and confirm predictors.
authors.affiliation: Department of Academic Geriatrics, Brighton and Sussex Medical School, Brighton, UK.
authors.forename: Tom J
authors.initials: TJ
authors.lastname: Levett
authors.affiliation: Department of HIV and Sexual Health, Royal Sussex County Hospital, Brighton, UK.
authors.forename: Fiona V
authors.initials: FV
authors.lastname: Cresswell
authors.affiliation: Postgraduate Medical Education, Brighton and Sussex Medical School, Brighton, UK.
authors.forename: Muzaffar A
authors.initials: MA
authors.lastname: Malik
authors.affiliation: Department of Medicine, Brighton and Sussex Medical School, Brighton, UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Fisher
authors.affiliation: Department of Academic Geriatrics, Brighton and Sussex Medical School, Brighton, UK.
authors.forename: Juliet
authors.initials: J
authors.lastname: Wright
mesh_terms: D000368:Aged; D016330:Frail Elderly; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D015995:Prevalence; D012307:Risk Factors
keywords: HIV; aging; frailty; prevalence