title: A Sensitive and Automatic White Matter Fiber Tracts Model for Longitudinal Analysis of Diffusion Tensor Images in Multiple Sclerosis.
abstract: Diffusion tensor imaging (DTI) is a sensitive tool for the assessment of microstructural alterations in brain white matter (WM). We propose a new processing technique to detect, local and global longitudinal changes of diffusivity metrics, in homologous regions along WM fiber-bundles. To this end, a reliable and automatic processing pipeline was developed in three steps: 1) co-registration and diffusion metrics computation, 2) tractography, bundle extraction and processing, and 3) longitudinal fiber-bundle analysis. The last step was based on an original Gaussian mixture model providing a fine analysis of fiber-bundle cross-sections, and allowing a sensitive detection of longitudinal changes along fibers. This method was tested on simulated and clinical data. High levels of F-Measure were obtained on simulated data. Experiments on cortico-spinal tract and inferior fronto-occipital fasciculi of five patients with Multiple Sclerosis (MS) included in a weekly follow-up protocol highlighted the greater sensitivity of this fiber scale approach to detect small longitudinal alterations.
authors.affiliation: CREATIS CNRS UMR5220 & INSERM U1044, Université de Lyon, Université Claude Bernard-Lyon 1, INSA-Lyon, Villeurbanne, France.
authors.forename: Claudio
authors.initials: C
authors.lastname: Stamile
authors.affiliation: CREATIS CNRS UMR5220 & INSERM U1044, Université de Lyon, Université Claude Bernard-Lyon 1, INSA-Lyon, Villeurbanne, France.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Kocevar
authors.affiliation: CREATIS CNRS UMR5220 & INSERM U1044, Université de Lyon, Université Claude Bernard-Lyon 1, INSA-Lyon, Villeurbanne, France.|Service de Radiologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, France.
authors.forename: François
authors.initials: F
authors.lastname: Cotton
authors.affiliation: CREATIS CNRS UMR5220 & INSERM U1044, Université de Lyon, Université Claude Bernard-Lyon 1, INSA-Lyon, Villeurbanne, France.|Service de Neurologie A, Hôpital Neurologique, Hospices Civils de Lyon, Bron, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Durand-Dubief
authors.affiliation: CREATIS CNRS UMR5220 & INSERM U1044, Université de Lyon, Université Claude Bernard-Lyon 1, INSA-Lyon, Villeurbanne, France.
authors.forename: Salem
authors.initials: S
authors.lastname: Hannoun
authors.affiliation: CREATIS CNRS UMR5220 & INSERM U1044, Université de Lyon, Université Claude Bernard-Lyon 1, INSA-Lyon, Villeurbanne, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Frindel
authors.affiliation: Center for Neurological Imaging, Departments of Radiology and Neurology, Brigham and Women's Hospital, Boston, MA, United States of America.
authors.forename: Charles R G
authors.initials: CR
authors.lastname: Guttmann
authors.affiliation: CREATIS CNRS UMR5220 & INSERM U1044, Université de Lyon, Université Claude Bernard-Lyon 1, INSA-Lyon, Villeurbanne, France.
authors.forename: David
authors.initials: D
authors.lastname: Rousseau
authors.affiliation: CREATIS CNRS UMR5220 & INSERM U1044, Université de Lyon, Université Claude Bernard-Lyon 1, INSA-Lyon, Villeurbanne, France.|CERMEP - Imagerie du Vivant, Université de Lyon, Bron, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Sappey-Marinier
mesh_terms: D000293:Adolescent; D000328:Adult; D057205:Automation, Laboratory; D001931:Brain Mapping; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging* / Q000473:pathology; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology*; D055815:Young Adult