title: The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) - Mechanisms and Opportunities.
abstract: Early T-Cell precursor acute lymphoblastic leukemia (ETP-ALL) is a relatively newly identified subset of T-lineage ALL. There are conflicting results regarding prognosis, and the genetic basis of this condition is variable. Here, we summarize the current status of the field and discuss the role of mutations in the Polycomb Repressive Complex 2 frequently identified in ETP-ALL patients.
authors.affiliation: Department of Pediatrics, Center for Cancer and Blood Disorders, Children's Hospital Colorado, University of Colorado Denver , Aurora, CO , USA.
authors.forename: Kathrin M
authors.initials: KM
authors.lastname: Bernt
authors.affiliation: Department of Pediatrics, Center for Childhood Cancer Research, The Children's Hospital of Philadelphia , Philadelphia, PA , USA.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Hunger
authors.affiliation: Department of Pediatrics, Center for Cancer and Blood Disorders, Children's Hospital Colorado, University of Colorado Denver , Aurora, CO , USA.
authors.forename: Tobias
authors.initials: T
authors.lastname: Neff
keywords: Hox genes; JAK/STAT signaling pathway; epigenetics; leukemia; lymphoid; polycomb repressive complex