title: Comparison of Amplitude-Integrated EEG and Conventional EEG in a Cohort of Premature Infants.
abstract: OBJECTIVE
  To compare amplitude-integrated EEG (aEEG) and conventional EEG (EEG) activity in premature neonates.
  
  
  METHODS
  Biweekly aEEG and EEG were simultaneously recorded in a cohort of infants born less than 34 weeks gestation. aEEG recordings were visually assessed for lower and upper border amplitude and bandwidth. EEG recordings were compressed for visual evaluation of continuity and assessed using a signal processing software for interburst intervals (IBI) and frequencies' amplitude. Ten-minute segments of aEEG and EEG indices were compared using regression analysis.
  
  
  RESULTS
  A total of 189 recordings from 67 infants were made, from which 1697 aEEG/EEG pairs of 10-minute segments were assessed. Good concordance was found for visual assessment of continuity between the 2 methods. EEG IBI, alpha and theta frequencies' amplitudes were negatively correlated to the aEEG lower border while conceptional age (CA) was positively correlated to aEEG lower border ( P < .001). IBI and all frequencies' amplitude were positively correlated to the upper aEEG border ( P ≤ .001). CA was negatively correlated to aEEG span while IBI, alpha, beta, and theta frequencies' amplitude were positively correlated to the aEEG span.
  
  
  CONCLUSIONS
  Important information is retained and integrated in the transformation of premature neonatal EEG to aEEG.
  
  
  CONCLUSIONS
  aEEG recordings in high-risk premature neonates reflect reliably EEG background information related to continuity and amplitude.
authors.affiliation: 1 Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.|2 Neonatal Department, Soroka Medical Center, Beer Sheva, Israel.
authors.forename: Irina
authors.initials: I
authors.lastname: Meledin
authors.affiliation: 1 Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.|3 Clinical Research Center, Soroka Medical Center, Beer Sheva, Israel.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Abu Tailakh
authors.affiliation: 4 S. Gilat Medical Research & Equipment Ltd, Karkur, Israel.
authors.forename: Shlomo
authors.initials: S
authors.lastname: Gilat
authors.affiliation: 5 Academic College of Tel-Aviv Yaffo, Tel Aviv, Israel.
authors.forename: Hagai
authors.initials: H
authors.lastname: Yogev
authors.affiliation: 1 Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.|2 Neonatal Department, Soroka Medical Center, Beer Sheva, Israel.
authors.forename: Agneta
authors.initials: A
authors.lastname: Golan
authors.affiliation: 1 Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.|3 Clinical Research Center, Soroka Medical Center, Beer Sheva, Israel.
authors.forename: Victor
authors.initials: V
authors.lastname: Novack
authors.affiliation: 1 Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.|2 Neonatal Department, Soroka Medical Center, Beer Sheva, Israel.
authors.forename: Eilon
authors.initials: E
authors.lastname: Shany
mesh_terms: D000465:Algorithms; D001921:Brain / Q000503:physiopathology*; D015331:Cohort Studies; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018511:Systems Integration
keywords: Amplitude-integrated electroencephalography; conventional electroencephalography; medical devices comparison; prematurity