title: Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing.
abstract: Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro.
authors.affiliation: Materials Science and Engineering Program, La Jolla, CA 92093, USA. rlal@ucsd.edu.
authors.forename: Alexander H
authors.initials: AH
authors.lastname: Mo
authors.affiliation: Dept. of Bioengineering, La Jolla, CA 92093, USA. plandon@ucsd.edu and Dept. of Mechanical and Aerospace Engineering & Institute of Engineering in Medicine, La Jolla, CA 92093, USA.
authors.forename: Preston B
authors.initials: PB
authors.lastname: Landon
authors.affiliation: Dept. of Mechanical and Aerospace Engineering & Institute of Engineering in Medicine, La Jolla, CA 92093, USA and Departamento de Física, Universidad de Sonora, Hermosillo, Sonora, México.
authors.forename: Karla Santacruz
authors.initials: KS
authors.lastname: Gomez
authors.affiliation: Materials Science and Engineering Program, La Jolla, CA 92093, USA. rlal@ucsd.edu and Dept. of Bioengineering, La Jolla, CA 92093, USA. plandon@ucsd.edu.
authors.forename: Heemin
authors.initials: H
authors.lastname: Kang
authors.affiliation: Materials Science and Engineering Program, La Jolla, CA 92093, USA. rlal@ucsd.edu.
authors.forename: Joon
authors.initials: J
authors.lastname: Lee
authors.affiliation: Dept. of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Dept. of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Woraphong
authors.initials: W
authors.lastname: Janetanakit
authors.affiliation: Dept. of Bioengineering, La Jolla, CA 92093, USA. plandon@ucsd.edu.
authors.forename: Vrinda
authors.initials: V
authors.lastname: Sant
authors.affiliation: Dept. of Bioengineering, La Jolla, CA 92093, USA. plandon@ucsd.edu.
authors.forename: Tianyu
authors.initials: T
authors.lastname: Lu
authors.affiliation: Dept. of Bioengineering, La Jolla, CA 92093, USA. plandon@ucsd.edu.
authors.forename: David A
authors.initials: DA
authors.lastname: Colburn
authors.affiliation: Dept. of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Akkiraju
authors.affiliation: Dept. of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Samuel
authors.initials: S
authors.lastname: Dossou
authors.affiliation: Dept. of Bioengineering, La Jolla, CA 92093, USA. plandon@ucsd.edu.
authors.forename: Yue
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors.forename: Kuo-Fen
authors.initials: KF
authors.lastname: Lee
authors.affiliation: Materials Science and Engineering Program, La Jolla, CA 92093, USA. rlal@ucsd.edu and Dept. of Bioengineering, La Jolla, CA 92093, USA. plandon@ucsd.edu and Dept. of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Shyni
authors.initials: S
authors.lastname: Varghese
authors.affiliation: Dept. of Mechanical and Aerospace Engineering & Institute of Engineering in Medicine, La Jolla, CA 92093, USA.
authors.forename: Gennadi
authors.initials: G
authors.lastname: Glinsky
authors.affiliation: Materials Science and Engineering Program, La Jolla, CA 92093, USA. rlal@ucsd.edu and Dept. of Bioengineering, La Jolla, CA 92093, USA. plandon@ucsd.edu and Dept. of Mechanical and Aerospace Engineering & Institute of Engineering in Medicine, La Jolla, CA 92093, USA.
authors.forename: Ratnesh
authors.initials: R
authors.lastname: Lal
mesh_terms: D045744:Cell Line, Tumor; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011137:Polystyrenes; D012822:Silicon Dioxide / Q000737:chemistry*; D013059:Spectrum Analysis, Raman
chemical_list: D011137:Polystyrenes; D006046:Gold; D012822:Silicon Dioxide