title: Investigation of the Levels of Serum Amyloid A, YKL-40, and Pentraxin-3 in Patients with Familial Mediterranean Fever.
abstract: BACKGROUND
  Familial Mediterranean Fever (FMF) is an autosomal recessive form of recurrent episodes of fever and an autoinflammatory disease characterized by inflammation of the serous membranes. The clinical diagnosis is supported by the laboratory findings. This study investigated the relationship of Serum Amyloid A (SAA), YKL-40, and Pentraxin-3 (PTX-3) with the FMF disease.
  
  
  METHODS
  About 50 patients with FMF were enrolled in this study. Patients were divided into three groups according to disease severity score (mild, moderate, and severe). Thirty-seven healthy individuals were included as the control group. Serum SAA, YKL-40, and PTX-3 concentrations were measured using an ELISA kit.
  
  
  RESULTS
  Serum SAA and YKL-40 levels of FMF patients were significantly higher than in the control (P < 0.001). PTX-3 levels were found to be higher in patients even though there was no significant difference (P = 0.113). Whereas the positive predictive value was 71.9% for cut-off point of SAA, the positive predictive value was 83.3% for cut-off point of YKL-40. Whereas a significant correlation was detected in SAA and PTX-3 with YKL-40 (respectively; P = 0.036, P < 0.001), there was no correlation between the PTX-3 with SAA (P = 0.219).
  
  
  CONCLUSIONS
  YKL-40 can be used together with SAA to support the diagnosis of FMF and to monitor the severity of the disease. In this study, YKL-40 levels were examined for the first time in FMF patients and further studies are necessary using larger patient samples.
authors.affiliation: Department of Biochemistry, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey. dr_sefaciftci46@hotmail.com.
authors.forename: Sefa
authors.initials: S
authors.lastname: Ciftci
authors.affiliation: Department of Biochemistry, Turgut Ozal University Faculty of Medicine, Ankara, Turkey.
authors.forename: Huseyin Tugrul
authors.initials: HT
authors.lastname: Celik
authors.affiliation: Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Atukeren
authors.affiliation: Department of Pediatrics, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Nurdan
authors.initials: N
authors.lastname: Ciftci
authors.affiliation: Department of Internal Medicine, Sutcu Imam University Faculty of Medicine, Kahramanmaras, Turkey.
authors.forename: Mustafa Saygin
authors.initials: MS
authors.lastname: Deniz
authors.affiliation: Department of Nephrology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Coskun Yavuz
authors.affiliation: Department of Biochemistry, Turgut Ozal University Faculty of Medicine, Ankara, Turkey.
authors.forename: Fatmanur
authors.initials: F
authors.lastname: Hacievliyagil Kazanci
authors.affiliation: Department of Biochemistry, Turgut Ozal University Faculty of Medicine, Ankara, Turkey.
authors.forename: Sümeyye
authors.initials: S
authors.lastname: Gök
authors.affiliation: Department of Biochemistry, Turgut Ozal University Faculty of Medicine, Ankara, Turkey.
authors.forename: Hilmi
authors.initials: H
authors.lastname: Demirin
authors.affiliation: Department of Biochemistry, Turgut Ozal University Faculty of Medicine, Ankara, Turkey.
authors.forename: Muhammet Ramazan
authors.initials: MR
authors.lastname: Yigitoglu
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D000071451:Chitinase-3-Like Protein 1 / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D010505:Familial Mediterranean Fever / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000071451:Chitinase-3-Like Protein 1; D000685:Serum Amyloid A Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins; C084533:CHI3L1 protein, human
keywords: Familial Mediterranean Fever; PTX-3; Serum Amyloid A; YKL-40; inflammation