title: Therapeutic effect of tyndallized Lactobacillus rhamnosus IDCC 3201 on atopic dermatitis mediated by down-regulation of immunoglobulin E in NC/Nga mice.
abstract: The therapeutic effect of oral administration of Lactobacillus rhamnosus IDCC 3201 tyndallizate (RHT3201) on atopic dermatitis (AD)-like skin lesions in NC/Nga mice were investigated. After induction of dermatitis in NC/Nga mice with house-dust mite extract, each group was fed RHT3201 with 1 × 10(8) , 1 × 10(9) , or 1 × 10(10) cells orally once a day for 8 weeks. Dermatitis scores and frequency of scratching were improved by oral feeding with RHT3201. In contrast to the control group, RHT3201-fed mice showed significantly down-regulated mast cell numbers and serum immunoglobulin E (IgE) concentrations had significantly less IL4 in their axillary lymph node cells. The therapeutic effect of RHT3201 was found to be dose-dependent. These findings indicate that RHT3201 has potential for treating AD.
authors.affiliation: Research Laboratories, Ildong Pharmaceutical, 20, Samsung 1-ro 1-gil, Hwaseong 18449.|Department of Biotechnology and Bioengineering, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
authors.forename: Seung-Hun
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Research Laboratories, Ildong Pharmaceutical, 20, Samsung 1-ro 1-gil, Hwaseong 18449.
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Yoon
authors.affiliation: Research Laboratories, Ildong Pharmaceutical, 20, Samsung 1-ro 1-gil, Hwaseong 18449.
authors.forename: Young-Hoo
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Research Laboratories, Ildong Pharmaceutical, 20, Samsung 1-ro 1-gil, Hwaseong 18449.
authors.forename: Dong-Gu
authors.initials: DG
authors.lastname: Jeong
authors.affiliation: Research Laboratories, Ildong Pharmaceutical, 20, Samsung 1-ro 1-gil, Hwaseong 18449.
authors.forename: Soobong
authors.initials: S
authors.lastname: Park
authors.affiliation: Research Laboratories, Ildong Pharmaceutical, 20, Samsung 1-ro 1-gil, Hwaseong 18449.
authors.forename: Dae-Jung
authors.initials: DJ
authors.lastname: Kang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001706:Biopsy; D016207:Cytokines / Q000097:blood / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D004195:Disease Models, Animal; D005260:Female; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D007167:Immunotherapy; D052201:Lacticaseibacillus rhamnosus / Q000276:immunology* / Q000648:ultrastructure; D008198:Lymph Nodes / Q000276:immunology / Q000378:metabolism; D051379:Mice; D010641:Phenotype; D019936:Probiotics / Q000008:administration & dosage*
chemical_list: D016207:Cytokines; D007073:Immunoglobulin E
keywords: Lactobacillus rhamnosus; atopic dermatitis; immunoglobulin E; tyndallization