title: Genetic polymorphisms in TNIP1 increase the risk of gastric carcinoma.
abstract: The distribution and levels of TNIP1 in malignant and normal gastric mucosa are different, but it is not known whether TNIP1 polymorphisms are related to gastric carcinogenesis. To assess the association between four TNIP1 SNPs (rs3792792, rs4958881, rs7708392, rs10036748) and carcinogenesis, we used Sequenom Mass-ARRAY technology to determine the genotypes of 302 gastric carcinoma patients and 300 healthy controls in a Northwest Chinese Han population. These data were then compared using the Chi-square test/Fisher's exact test, genetic model analysis, and haplotype analysis. Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate the correlation. We observed that patients with the "G" allele of rs7708392 and the "C" allele of rs10036748 showed an increased risk of gastric carcinoma (OR= 1.335, 95%CI: 1.021-1.745, P= 0.035; OR= 1.358, 95%CI: 1.039-1.774, P= 0.025, respectively). Conversely, the haplotype "CT" of TNIP1 (rs7708392-rs10036748) may act as a genetic protective factor for gastric carcinoma (adjusted OR= 0.731, 95%CI: 0.552-0.970, P= 0.030). Our results are the first to suggest that genetic variation in TNIP1 gene is associated with gastric carcinoma, though, this finding must be confirmed in other populations with larger sample size.
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China.|Department of Surgery, Xi'an Chest Hospital, Xi'an TB&Thoracic Tumor Hospital, Xi'an 710100, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Medical Oncology, Graduate School of Inner Mongolia Medical University, Hohhot 010000, China.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Pediatric Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China.
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Na
authors.affiliation: Department of Medical, Xi'an Chest Hospital, Xi'an TB&Thoracic Tumor Hospital, Xi'an 710100, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Medical, Xi'an Chest Hospital, Xi'an TB&Thoracic Tumor Hospital, Xi'an 710100, China.
authors.forename: Sizhe
authors.initials: S
authors.lastname: Cao
authors.affiliation: Second Department of General Surgery, Shaanxi Province People's Hospital, Xi'an 710001, China.
authors.forename: Xianglong
authors.initials: X
authors.lastname: Duan
authors.affiliation: Department of Biochemistry, School of Life Sciences, Northwest University, Xi'an 710069, China.
authors.forename: Xiyang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry, School of Life Sciences, Northwest University, Xi'an 710069, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Biochemistry, School of Life Sciences, Northwest University, Xi'an 710069, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Department of General Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002277:Carcinoma / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C117046:TNIP1 protein, human
keywords: TNF-α-induced protein 3-interacting protein 1 (TNIP1); case-control study; gastric carcinoma; single nucleotide polymorphisms (SNPs)