title: Diagnostic and Prognostic Value of miR-1287 in Colorectal Cancer.
abstract: BACKGROUND
  MicroRNAs are non-coding RNAs that regulate the gene expression at post-transcriptional level. This futuristic study characterized the contribution of miR-1287 to the colorectal cancer (CRC) tumorigenesis.
  
  
  METHODS
  The real-time reverse transcription-polymerase chain reaction was used to examine miR-1287 expression levels, prospectively in 40 pairs of CRC tissue samples and adjacent noncancerous tissues (>2 cm from cancer tissue).
  
  
  RESULTS
  No significant relationship was found between miR-1287 expression levels and clinicopathological features. Showing significant changes overall, MiR-1287 was significantly upregulated in the group of CRC samples compared with matched noncancerous tissue samples. A receiver operating characteristic (ROC) curve also showed ROC area (AROC) of 34 % with 1.0 and 0.02 sensitivity and specificity, respectively. Expression of miR-1287, with a value of 0.34, P value = 1.98, and P > 0.05, revealed that this microRNA has a low sensitivity and specificity to be regarded as a tumor marker.
  
  
  CONCLUSIONS
  With regard to recent increased rate of CRC in the world, the present study may be a contribution, though very small, in the diagnosis and consequently in the treatment of CRC patients.
authors.affiliation: Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
authors.forename: Alavieh
authors.initials: A
authors.lastname: Fateh
authors.affiliation: Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran. pourfeizi@eastp.ir.
authors.forename: Mohammad Ali Hosseinpour
authors.initials: MA
authors.lastname: Feizi
authors.affiliation: Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Safaralizadeh
authors.affiliation: Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Azarbarzin
authors.affiliation: Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
authors.forename: Reyhaneh
authors.initials: R
authors.lastname: Ravanbakhsh
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor; C586026:MIRN1287 microRNA, human; D035683:MicroRNAs
keywords: Colorectal cancer; Tumor marker; miR-1287; microRNA