title: Perinatal outcome in women with prolonged premature rupture of membranes at term undergoing labor induction.
abstract: We aimed to evaluate perinatal outcome in women with prolonged (>24 h) premature rupture of membranes (PROM) undergoing induction of labor (IoL).
  
  
  
  We retrospectively assessed all women presenting with term (≥37 weeks) PROM and Bishop-score <7 in a tertiary hospital (2012-14). Women without spontaneous onset of labor <24 h from PROM underwent Prostaglandin E2 (PGE2) IoL and were compared to women with low Bishop-score who developed spontaneous onset of labor <24 h. Women with IoL at <24 h from PROM, women presenting in active labor at admission or women who did not attempt vaginal delivery were excluded.
  
  
  
  Among 15,563 deliveries 1,171 (8.2 %) admitted with term PROM. Of them, 625 (53 %) were eligible; 155 (24.8 %) in the induction group and 470 (75.2 %) served as comparison group. No significant difference was found between the groups regarding maternal age, parity and obstetrical complications. Women in the induction group were at increased risk for Cesarean section (CS) (OR 8.27, CI 1.30-52.36, p = 0.025) and especially CS due to labor dystocia (2.97, 1.20-7.36, p = 0.018). The rate of neonatal complications was comparable between the groups.
  
  
  
  Women undergoing IoL for prolonged term PROM were at increased risk for CS compared to those with spontaneous onset of labor. However, neonatal outcome was comparable between the groups.
authors.affiliation: Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Rabin Medical Center, 49100, Petach Tikva, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Eran
authors.initials: E
authors.lastname: Ashwal
authors.affiliation: Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Rabin Medical Center, 49100, Petach Tikva, Israel. eyalkrispin@gmail.com.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. eyalkrispin@gmail.com.
authors.forename: Eyal
authors.initials: E
authors.lastname: Krispin
authors.affiliation: Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Rabin Medical Center, 49100, Petach Tikva, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Amir
authors.initials: A
authors.lastname: Aviram
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Ella
authors.initials: E
authors.lastname: Aleyraz
authors.affiliation: Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Rabin Medical Center, 49100, Petach Tikva, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Rinat
authors.initials: R
authors.lastname: Gabby-Benziv
authors.affiliation: Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Rabin Medical Center, 49100, Petach Tikva, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Arnon
authors.initials: A
authors.lastname: Wiznitzer
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Yariv
authors.initials: Y
authors.lastname: Yogev
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Liran
authors.initials: L
authors.lastname: Hiersch
mesh_terms: D000328:Adult; D002585:Cesarean Section; D015331:Cohort Studies; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology* / Q000503:physiopathology*; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007751:Labor, Induced / Q000706:statistics & numerical data*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Cesarean section; Induction of labor; Outcome; Premature rupture of membranes