title: Marine Depsipeptides as Promising Pharmacotherapeutic Agents.
abstract: Depsipeptides are a group of biologically active peptides that have at least one of the amide bonds replaced by an ester bond. These peptides sometimes present additional chemical modifications, including unusual amino acid residues in their structures. Depsipeptides are known to exhibit a large array of bioactivities, such as anticancer, antiproliferative, antimicrobial, antiviral and antiplasmodial properties. They are commonly found in marine organisms: bacteria, tunicates, mollusks, sponges, and others. Herein, we summarize the latest insights about marine depsipeptides, their mechanisms of action and potential as therapeutic agents.
authors.affiliation: Laboratory of Immunopathology, Butantan Institute, São Paulo-SP, Brazil.
authors.forename: Marisa
authors.initials: M
authors.lastname: Rangel
authors.forename: Carlos José Correia
authors.initials: CJ
authors.lastname: de Santana
authors.forename: Andréia
authors.initials: A
authors.lastname: Pinheiro
authors.forename: Lilian
authors.initials: L
authors.lastname: Dos Anjos
authors.forename: Tania
authors.initials: T
authors.lastname: Barth
authors.forename: Osmindo Rodrigues
authors.initials: OR
authors.lastname: Pires
authors.forename: Wagner
authors.initials: W
authors.lastname: Fontes
authors.affiliation: Laboratory of Toxinology, Department of Physiological Sciences/IB, University of Brasília, Brasília-DF, Brazil, 70910-900.
authors.forename: Mariana S
authors.initials: MS
authors.lastname: Castro
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D059001:Aquatic Organisms / Q000737:chemistry*; D002986:Clinical Trials as Topic; D047630:Depsipeptides / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006801:Humans; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic