title: [French shift workers seen at health centres have an increased risk of lipid disorders].
abstract: OBJECTIVE
  To describe cardiovascular risk factors and metabolic disturbances in a French population including shift workers and study whether possible changes were noticeable after non-shift to shift work transition within the last five years.
  
  
  METHODS
  The study population included 4764 attendees of two health examinations (5 years apart), between January 1996 and October 2008, in 11 health examination centres. Clinical, biological and metabolic factors together with their changes over a five-year period were compared between attendees who kept a non-shift daytime job, those who kept working shift and those who switched from non-shift daytime to shift work over the last 5 years.
  
  
  RESULTS
  At baseline, working shift was, independently of lifestyle or BMI, significantly related to more elevated plasma triglycerides (β=0.04, P=0.05) and rate of hypertriglyceridemia (β=0.27, P=0.01), lower plasma HDL-C levels (β=-2.03, P=0.006) and less hypertension (β=-0.25, P=0.01) compared to non-shift daytime work. In men, a slightly more elevated yet non significant proportion of hypertriglyceridemia was observed with the transition from non-shift daytime to shift work within the last 5 years in comparison to men who kept a non-shift daytime job (13.9% vs. 11.0% P=0.17).
  
  
  CONCLUSIONS
  Our results are in agreement with previous studies showing a deleterious effect of shift work on lipid metabolism. In our population, triglycerides and HDL-C levels were the main parameters negatively influenced by shift work. Consequently, a regular biological monitoring together with the promotion of healthy behaviours should be provided to shift workers before negative consequences of working shift become noticeable.
authors.affiliation: Institut inter-régional pour la santé, 45, rue de la Parmentière, BP 122, 37521 La-Riche cedex, France. Electronic address: nane.copin@uc-irsa.fr.
authors.forename: Nane
authors.initials: N
authors.lastname: Copin
authors.affiliation: Institut inter-régional pour la santé, 45, rue de la Parmentière, BP 122, 37521 La-Riche cedex, France.
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Gusto
authors.affiliation: Institut inter-régional pour la santé, 45, rue de la Parmentière, BP 122, 37521 La-Riche cedex, France.
authors.forename: Sylviane
authors.initials: S
authors.lastname: Vol
authors.affiliation: Institut inter-régional pour la santé, 45, rue de la Parmentière, BP 122, 37521 La-Riche cedex, France.
authors.forename: Sloane
authors.initials: S
authors.lastname: Rollier
authors.affiliation: Institut inter-régional pour la santé, 45, rue de la Parmentière, BP 122, 37521 La-Riche cedex, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lantieri
authors.affiliation: Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail, 27/31, avenue du Général-Leclerc, 94701 Maisons-Alfort cedex, France; CHRU université François-Rabelais, 10, boulevard Tonnellé, 37132 Tours cedex 01, France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Lasfargues
authors.affiliation: Institut inter-régional pour la santé, 45, rue de la Parmentière, BP 122, 37521 La-Riche cedex, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Tichet
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D050171:Dyslipidemias / Q000453:epidemiology*; D005260:Female; D005602:France; D006282:Health Personnel; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology*; D018570:Risk Assessment; D014940:Work Schedule Tolerance