title: Diabetes impairs spatial learning and memory and hippocampal neurogenesis via BDNF in rats with transient global ischemia.
abstract: Diabetic conditions worsen the prognosis of stroke. The molecular mechanism underlying the impairment of post-stroke recovery is not very clear. Here, we establish a rat model resembling human cerebral infarction with or without diabetes to determine how diabetes impairs cognitive recovery. Our data show that diabetes inhibits hippocampal BDNF expression and impairs the survival and differentiation of the newborn neural cells in rats with ischemia. Consequently, the rats of diabetic ischemia have a significantly lower score in spatial learning and memory in the Morris water maze test than the non-diabetic ischemia model rats. On the other hand, treatment with BDNF effectively improves hippocampal neurogenesis and the spatial learning and memory in rat with diabetic ischemia. All together, our data suggest that diabetes impaired spatial learning and memory and hippocampal neurogenesis in rats with ischemia by inhibition of the BDNF expression in the hippocampus.
authors.affiliation: Department of Neurology, First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230031, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Han
authors.affiliation: Medical center, Center for reproductive medicine and prenatal diagnosis, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, China. Electronic address: wlm@ustc.edu.cn.
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Wu
authors.affiliation: Medical Department, First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230031, China.
authors.forename: Ming-Xiang
authors.initials: MX
authors.lastname: Han
authors.affiliation: Department of Neurology, First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230031, China.
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Yang
authors.affiliation: Department of Neurology, First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230031, China.
authors.forename: Yan-Xin
authors.initials: YX
authors.lastname: Wang
authors.affiliation: Medical Department, First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230031, China.
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Fang
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D019208:Brain-Derived Neurotrophic Factor / Q000008:administration & dosage / Q000378:metabolism*; D001973:Bromodeoxyuridine; D049109:Cell Proliferation / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D004195:Disease Models, Animal; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D002546:Ischemic Attack, Transient / Q000150:complications*; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000209:etiology* / Q000473:pathology*; D055495:Neurogenesis / Q000187:drug effects / Q000502:physiology*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D065853:Spatial Learning / Q000187:drug effects / Q000502:physiology*; D013311:Streptozocin / Q000633:toxicity; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D000903:Antibiotics, Antineoplastic; D019208:Brain-Derived Neurotrophic Factor; D005904:Glial Fibrillary Acidic Protein; D013311:Streptozocin; D010751:Phosphopyruvate Hydratase; D001973:Bromodeoxyuridine
keywords: BDNF; Diabetes; Hippocampus; Neurogenesis; Spatial learning and memory; Transient global cerebral ischemia