title: Bone Mineral Density Is Negatively Associated With Arterial Stiffness in Men With Hypertension.
abstract: Hypertension (HTN) and osteoporosis are associated with the development and progress of atherosclerosis. However, little research has been conducted to examine the relationship between arterial stiffness and bone mineral density (BMD) in men with HTN. This cross-sectional study recruited 355 men with HTN and 353 control patients without HTN. Brachial-ankle pulse wave velocity (baPWV) and BMD measurements were performed. BMD was decreased and baPWV was elevated in patients with HTN compared with control patients (femoral neck [FN] BMD in the HTN and control groups were 0.662±0.195 g/cm2and 0.713±0.204 g/cm2, respectively [P=.001], and baPWV in the HTN and control groups were 1403.3±156.8 cm/s and 1354.8±136.0 cm/s, respectively [P<.001]). Multiple linear regression analysis demonstrated that FN BMD was negatively associated with increased baPWV in HTN. Reduced FN BMD may be an independent factor for baPWV in patients with HTN.
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Li
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Hui
authors.initials: H
authors.lastname: He
authors.affiliation: Harbin Medical University (Da Qing), Harbin, Heilongjiang, China.
authors.forename: Yi-Lin
authors.initials: YL
authors.lastname: Zhao
authors.affiliation: Department of Geriatrics, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Departments of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Liu
authors.affiliation: Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX.
authors.forename: Tiemin
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Intensive Care Unit, The Third Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Kai-Jiang
authors.initials: KJ
authors.lastname: Yu
authors.affiliation: Department of Intensive Care Unit, The Third Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China. ruitaowang@126.com.
authors.forename: Rui-Tao
authors.initials: RT
authors.lastname: Wang
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D015519:Bone Density; D003430:Cross-Sectional Studies; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness