title: Tri-modal microscope for head and neck tissue identification.
abstract: A novel tri-modal microscope combining optical coherence tomography (OCT), spectrally encoded confocal microscopy (SECM) and fluorescence imaging is presented. This system aims at providing a tool for rapid identification of head and neck tissues during thyroid surgery. The development of a dual-wavelength polygon-based swept laser allows for synchronized, co-registered and simultaneous imaging with all three modalities. Further ameliorations towards miniaturization include a custom lens for optimal compromise between orthogonal imaging geometries as well as a double-clad fiber coupler for increased throughput. Image quality and co-registration is demonstrated on freshly excised swine head and neck tissue samples to illustrate the complementarity of the techniques for identifying signature cellular and structural features.
authors.affiliation: COPL, Department of Engineering Physics, Ecole Polytechnique Montreal, Montreal, Canada; Montreal University Health Center, Montreal, Canada.
authors.forename: Etienne
authors.initials: E
authors.lastname: De Montigny
authors.affiliation: COPL, Department of Engineering Physics, Ecole Polytechnique Montreal, Montreal, Canada.
authors.forename: Nadir
authors.initials: N
authors.lastname: Goulamhoussen
authors.affiliation: COPL, Department of Engineering Physics, Ecole Polytechnique Montreal, Montreal, Canada; Montreal University Health Center, Montreal, Canada.
authors.forename: Wendy-Julie
authors.initials: WJ
authors.lastname: Madore
authors.affiliation: COPL, Department of Engineering Physics, Ecole Polytechnique Montreal, Montreal, Canada.
authors.forename: Mathias
authors.initials: M
authors.lastname: Strupler
authors.affiliation: Montreal University Health Center, Montreal, Canada.
authors.forename: Olguta Ecaterina
authors.initials: OE
authors.lastname: Gologan
authors.affiliation: Montreal University Health Center, Montreal, Canada.
authors.forename: Tareck
authors.initials: T
authors.lastname: Ayad
authors.affiliation: COPL, Department of Engineering Physics, Ecole Polytechnique Montreal, Montreal, Canada.
authors.forename: Caroline
authors.initials: C
authors.lastname: Boudoux
keywords: (110.2350) Fiber optics imaging; (110.4500) Optical coherence tomography; (120.3890) Medical optics instrumentation; (170.1790) Confocal microscopy; (170.2520) Fluorescence microscopy; (170.4940) Otolaryngology