title: TRPV1-FAAH-COX: The Couples Game in Pain Treatment.
abstract: Pain is a complex sensation involving the perception and transduction of diverse environmental pain stimuli with cognitive and emotional processing by the central nervous system. It can manifest as acute or chronic pain. Pain is controlled by a series of enzymes and receptors, implicated in a variety of interconnected mechanisms and pathways. In fact, several studies have shown the cannabinoid receptor 1 and the transient receptor potential vanilloid channel 1 to be new players in modulating the sophisticated pain transduction system at the central level. At the peripheral level, the perception of pain involves cyclooxygenases and fatty acid amide hydrolase, as recent studies demonstrate. This Minireview describes the physiological aspects of the receptors and enzymes mentioned above and focuses on the consideration of dual mechanisms as a new therapeutic approach in the treatment of pain.
authors.affiliation: Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, Edificio Polifunzionale, 87036, Arcavacata, Rende, Italy.
authors.forename: Francesca
authors.identifier: 0000-0001-6846-5582
authors.initials: F
authors.lastname: Aiello
authors.affiliation: Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, Edificio Polifunzionale, 87036, Arcavacata, Rende, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Carullo
authors.affiliation: Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, Edificio Polifunzionale, 87036, Arcavacata, Rende, Italy.
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Badolato
authors.affiliation: Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, Polo Scientifico S. Miniato, 53100, Siena, Italy. antonella.brizzi@unisi.it.
authors.forename: Antonella
authors.identifier: 0000-0002-2310-9899
authors.initials: A
authors.lastname: Brizzi
mesh_terms: D000581:Amidohydrolases / Q000378:metabolism*; D000818:Animals; D006801:Humans; D010146:Pain / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D050916:TRPV Cation Channels / Q000378:metabolism*; D000099252:Fatty Acid Amide Hydrolases
chemical_list: D000581:Amidohydrolases; D011451:Prostaglandin-Endoperoxide Synthases; D050916:TRPV Cation Channels; D000099252:Fatty Acid Amide Hydrolases
keywords: drug discovery; dual inhibitors; enzymes; pain treatment; receptors