title: Novel Cadmium Zinc Telluride Devices for Myocardial Perfusion Imaging-Technological Aspects and Clinical Applications.
abstract: Myocardial perfusion imaging plays an important role in the assessment of patients with known or suspected coronary artery disease and is well established for diagnosis and for prognostic evaluation in these patients. The dedicated cardiac SPECT cameras with solid-state cadmium zinc telluride (CZT) detectors were first introduced a decade ago. A large body of evidence is building up, showing the superiority of the new technology compared with conventional gamma cameras. Not only the CZT detectors, but also new collimator geometries, the ability to perform focused imaging optimized for the heart and advances in data processing algorithms all contribute to the significantly improved sensitivity up to 8-10 times, as well as improved energy resolution and improved reconstructed spatial resolution compared with conventional technology. In this article, we provide an overview of the physical characteristics of the CZT cameras, as well as a review of the literature published so far, including validation studies in comparison with conventional myocardial perfusion imaging and with invasive coronary angiography, significant reduction in radiation dose, and new imaging protocols enabled by the new technology.
authors.affiliation: Institute of Nuclear Medicine, University College London and UCL Hospital, NHS Foundation Trust, London, UK; Department of Nuclear Medicine, Chaim Sheba Medical Center, Tel-Hashomer, Israel. Electronic address: simona.ben-haim@sheba.health.gov.il.
authors.forename: Simona
authors.initials: S
authors.lastname: Ben-Haim
authors.affiliation: Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, Israel; B. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: John
authors.initials: J
authors.lastname: Kennedy
authors.affiliation: Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, Israel; B. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Zohar
authors.initials: Z
authors.lastname: Keidar
mesh_terms: D002104:Cadmium; D006801:Humans; D055414:Myocardial Perfusion Imaging / Q000295:instrumentation / Q000379:methods*; D011829:Radiation Dosage; D013691:Tellurium; D015899:Tomography, Emission-Computed, Single-Photon; D015032:Zinc
chemical_list: C474490:CdZnTe; D002104:Cadmium; D015032:Zinc; D013691:Tellurium