title: Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration.
abstract: Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by the short in vivo half-lives and the narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. In this research, a nanoscale controlled release system (degradable protein nanocapsule) is established via in situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes can be achieved with growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 nanocapsules.
authors.affiliation: Department of Surgery, Bethune School of Medics , Shijiazhuang 050000, China.|Department of Orthopaedic Surgery, Changzheng Hospital, Second Military Medical University , Shanghai 200003, China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Tian
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Du
authors.forename: Jing
authors.initials: J
authors.lastname: Wen
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Scott R
authors.initials: SR
authors.lastname: Montgomery
authors.forename: Trevor P
authors.initials: TP
authors.lastname: Scott
authors.forename: Bayan
authors.initials: B
authors.lastname: Aghdasi
authors.forename: Chengjie
authors.initials: C
authors.lastname: Xiong
authors.forename: Akinobu
authors.initials: A
authors.lastname: Suzuki
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Hayashi
authors.forename: Monchai
authors.initials: M
authors.lastname: Ruangchainikom
authors.forename: Kevin
authors.initials: K
authors.lastname: Phan
authors.forename: Gil
authors.initials: G
authors.lastname: Weintraub
authors.forename: Alobaidaan
authors.initials: A
authors.lastname: Raed
authors.affiliation: Research Service, VA Greater Los Angeles Healthcare System , North Hills, California 91343, United States.
authors.forename: Samuel S
authors.initials: SS
authors.lastname: Murray
authors.affiliation: Division of Orthopaedic Surgery, Department of Surgery, University of Nevada School of Medicine , Las Vegas, Nevada 89102, United States.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Daubs
authors.affiliation: Department of Material Science, Tianjin University , Tianjin 300072, China.
authors.forename: Xianjin
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Material Science, Tianjin University , Tianjin 300072, China.
authors.forename: Xu-Bo
authors.initials: XB
authors.lastname: Yuan
authors.affiliation: Department of Orthopaedic Surgery, University of Southern California , Los Angeles, California 90033, United States.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Wang
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Lu
mesh_terms: D001861:Bone Regeneration; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D011108:Polymers
chemical_list: D003692:Delayed-Action Preparations; D053769:Nanocapsules; D011108:Polymers
keywords: bone regeneration; controlled release; degradable polymer; inflammation; protein nanocapsule