title: Stromal Cell-Derived Factor-1 Alpha Is Decreased in Women With Migraine With Aura.
abstract: BACKGROUND
  Endothelial dysfunction may contribute to the pathophysiology of migraine with aura. Stromal cell-derived factor-1 alpha (SDF-1α) is involved in the maintenance of endothelial integrity via mobilization of vascular stem cells.
  
  
  OBJECTIVE
  We sought to determine whether SDF-1α levels are decreased in women with MA.
  
  
  METHODS
  In this post hoc analysis of a case-cohort study, levels of SDF-1α were determined by enzyme-linked immunosorbent assay. Endothelial function was assessed using peripheral arterial tonometry. Arterial stiffness was assessed by fingertip tonometry derived and heart-rate-adjusted augmentation index (AI).
  
  
  RESULTS
  Twenty-eight women with MA and 27 age-matched healthy women were included in this study. Levels of SDF-1α were significantly lower in women with MA compared to age- and risk factor-matched healthy women (1763 ± 281 vs 2013 ± 263 pg/mL, P = 0.006). SDF-1α levels were positively correlated with AI in healthy women (r = 0.49, P = 0.009), but not in women with MA (r = 0.05, P = 0.78). SDF-1α levels were negatively correlated with CD144-positive endothelial microparticles (EMP; r = -0.31, P = .02), and activated CD62E-positive EMP (r = -0.35, P = .01).
  
  
  CONCLUSIONS
  Levels of SDF-1α are decreased in women with MA and are associated with EMPs as a surrogate marker of endothelial dysfunction. This might contribute to the pathophysiology and vascular risk in MA, but evidence from larger prospective studies is warranted.
authors.affiliation: Center for Stroke Research Berlin, Charité - Universitätsmedizin, Berlin, Germany. thomas.liman@charite.de.|Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. thomas.liman@charite.de.|Department of Neurology, Charité - Universitätsmedizin, Berlin, Germany. thomas.liman@charite.de.
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Liman
authors.affiliation: Center for Stroke Research Berlin, Charité - Universitätsmedizin, Berlin, Germany.|Department of Neurology, Charité - Universitätsmedizin, Berlin, Germany.
authors.forename: Lars
authors.initials: L
authors.lastname: Neeb
authors.affiliation: Center for Stroke Research Berlin, Charité - Universitätsmedizin, Berlin, Germany.
authors.forename: Jana
authors.initials: J
authors.lastname: Rosinski
authors.affiliation: Department of Neurology, Charité - Universitätsmedizin, Berlin, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Reuter
authors.affiliation: Center for Stroke Research Berlin, Charité - Universitätsmedizin, Berlin, Germany.|Department of Neurology, Charité - Universitätsmedizin, Berlin, Germany.|German Center for Neurodegenerative Disease (DZNE), Charité - Universitätsmedizin, Berlin, Germany.|Excellence Cluster Neurocure, Charité - Universitätsmedizin, Berlin, Germany.|German Center for Cardiovascular Research (DZHK), Berlin, Germany.|Berlin Institute of Health (BIH), Berlin, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Endres
mesh_terms: D000328:Adult; D001158:Arteries / Q000503:physiopathology; D015415:Biomarkers / Q000378:metabolism; D054377:Chemokine CXCL12 / Q000378:metabolism*; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005385:Fingers / Q000098:blood supply / Q000503:physiopathology; D006801:Humans; D008365:Manometry; D020325:Migraine with Aura / Q000378:metabolism*; D059289:Vascular Stiffness / Q000502:physiology
chemical_list: D015415:Biomarkers; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12
keywords: endothelial dysfunction; migraine; stroke risk; stromal cell-derived factor-1 alpha