title: Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting.
abstract: Historical and current concepts of in vitro fibrillogenesis are considered in the light of disorders in which amyloid is deposited at anatomic sites remote from the site of synthesis of the corresponding precursor protein. These clinical conditions set constraints on the interpretation of information derived from in vitro fibrillogenesis studies. They suggest that in addition to kinetic and thermodynamic factors identified in vitro, fibrillogenesis in vivo is determined by site specific factors most of which have yet to be identified.
authors.affiliation: Department of Pathology and Molecular Medicine, Queen's University Kingston, ON, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Kisilevsky
authors.affiliation: Unit of Biochemistry, Department of Molecular Medicine, University of Pavia Pavia, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Raimondi
authors.affiliation: Unit of Biochemistry, Department of Molecular Medicine, University of PaviaPavia, Italy; Wolfson Drug Discovery Unit, Division of Medicine, Centre for Amyloidosis and Acute Phase Proteins, University College LondonLondon, UK.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Bellotti
keywords: historical perspectives; in-vivo/in-vitro comparisons; site specific amyloid tissue deposition