title: Increased blood flow and vasculature in solar lentigo.
abstract: Solar lentigo (SL) is a hallmark of ultraviolet (UV)-induced photoaged skin and growing evidence implicates blood vessels in UV-associated pigmentation. In this study, we investigated whether the vasculatures are modified in SL. Twenty-five women with facial SL were enrolled and colorimetric and blood flow studies were performed. There was a significant increase in erythema which was associated with increased blood flow in the lesional skin compared with perilesional normal skin. Immunohistochemical studies with 24 facial SL biopsies consistently revealed a significant increase in vessel density accompanied by increased levels of vascular endothelial growth factor expression. CD68 immunoreactivity was significantly higher in lesional skin suggesting increased macrophage infiltration in SL. In conclusion, SL is characterized by increased blood flow and vasculature. These findings suggest the possible influence of the characteristics of vasculature on development of SL.
authors.affiliation: Shiseido Global Innovation Center, Yokohama, Japan.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Hasegawa
authors.affiliation: Shiseido Global Innovation Center, Yokohama, Japan.
authors.forename: Rumiko
authors.initials: R
authors.lastname: Fujiwara
authors.affiliation: Shiseido Global Innovation Center, Yokohama, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Sato
authors.affiliation: Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Ji-Youn
authors.initials: JY
authors.lastname: Park
authors.affiliation: Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Sang Jin
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.|Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Korea.
authors.forename: Misun
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Ajou University School of Medicine, Suwon, Korea. hykang@ajou.ac.kr.|Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Korea. hykang@ajou.ac.kr.
authors.forename: Hee Young
authors.initials: HY
authors.lastname: Kang
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001706:Biopsy; D001783:Blood Flow Velocity; D003124:Colorimetry; D020405:Dermis / Q000098:blood supply* / Q000503:physiopathology; D004890:Erythema / Q000503:physiopathology; D005145:Face; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007911:Lentigo / Q000209:etiology / Q000503:physiopathology*; D008875:Middle Aged; D012189:Retrospective Studies; D015595:Skin Aging / Q000473:pathology* / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D042461:Vascular Endothelial Growth Factor A; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C467484:VEGFA protein, human
keywords: blood vessel; hyperpigmentation; lentigo; macrophage; vascular endothelial growth factor