title: Sleep-wake profiles predict longitudinal changes in manic symptoms and memory in young people with mood disorders.
abstract: Mood disorders are characterized by disabling symptoms and cognitive difficulties which may vary in intensity throughout the course of the illness. Sleep-wake cycles and circadian rhythms influence emotional regulation and cognitive functions. However, the relationships between the sleep-wake disturbances experienced commonly by people with mood disorders and the longitudinal changes in their clinical and cognitive profile are not well characterized. This study investigated associations between initial sleep-wake patterns and longitudinal changes in mood symptoms and cognitive functions in 50 young people (aged 13-33 years) with depression or bipolar disorder. Data were based on actigraphy monitoring conducted over approximately 2 weeks and clinical and neuropsychological assessment. As part of a longitudinal cohort study, these assessments were repeated after a mean follow-up interval of 18.9 months. No significant differences in longitudinal clinical changes were found between the participants with depression and those with bipolar disorder. Lower sleep efficiency was predictive of longitudinal worsening in manic symptoms (P = 0.007). Shorter total sleep time (P = 0.043) and poorer circadian rhythmicity (P = 0.045) were predictive of worsening in verbal memory. These findings suggest that some sleep-wake and circadian disturbances in young people with mood disorders may be associated with less favourable longitudinal outcomes, notably for subsequent manic symptoms and memory difficulties.
authors.affiliation: Clinical Research Unit, Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.
authors.forename: Rébecca
authors.initials: R
authors.lastname: Robillard
authors.affiliation: Clinical Research Unit, Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Hermens
authors.affiliation: Clinical Research Unit, Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.
authors.forename: Rico S C
authors.initials: RS
authors.lastname: Lee
authors.affiliation: Clinical Research Unit, Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Jones
authors.affiliation: Clinical Research Unit, Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.
authors.forename: Joanne S
authors.initials: JS
authors.lastname: Carpenter
authors.affiliation: Clinical Research Unit, Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.
authors.forename: Django
authors.initials: D
authors.lastname: White
authors.affiliation: Clinical Research Unit, Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Naismith
authors.affiliation: Clinical Research Unit, Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.
authors.forename: James
authors.initials: J
authors.lastname: Southan
authors.affiliation: Clinical Research Unit, Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.
authors.forename: Bradley
authors.initials: B
authors.lastname: Whitwell
authors.affiliation: Clinical Research Unit, Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Scott
authors.affiliation: Clinical Research Unit, Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia. ian.hickie@sydney.edu.au.
authors.forename: Ian B
authors.initials: IB
authors.lastname: Hickie
mesh_terms: D056044:Actigraphy; D000293:Adolescent; D000328:Adult; D000339:Affect; D001714:Bipolar Disorder / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D002940:Circadian Rhythm / Q000502:physiology; D003071:Cognition / Q000502:physiology; D003866:Depressive Disorder / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007802:Language; D008137:Longitudinal Studies; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000150:complications / Q000503:physiopathology / Q000523:psychology; D013997:Time Factors; D014851:Wakefulness / Q000502:physiology*; D055815:Young Adult
keywords: affective disorders; cognition; neuropsychology