title: The effect of cyclin-dependent kinases inhibitor treatment on experimental herpes simplex encephalitis mice.
abstract: Herpes simplex encephalitis(HSE) is the most common and serious viral encephalitis in humans. There is a lack of effective medication to date for HSE. A better understanding of the mediators of tissue damage is essential for finding new targets for therapeutic intervention. In this project, we explored the effect of cyclin-dependent kinases inhibitor olomoucine treatment on experimental HSE mice. The following results were obtained: (1) olomoucine increased survival in HSE mice; (2) olomoucine inhibited microglial activation and reduced HSV-1-induced cytokines release; (3) olomoucine prevented neural cells apoptosis and attenuated brain tissue pathological changes following HSV-1 infection; (4) olomoucine reduced brain edema and improved neurological function in HSE. Overall, olomoucine can induce a blunted inflammatory response, maintain the blood vessel wall intact, improve neurological function and increase survival in HSE mice.
authors.affiliation: Department of Neurology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, China. Electronic address: zhouyu131@gmail.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Zeng
authors.affiliation: Department of Neurology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, China.
authors.forename: Jing-Xia
authors.initials: JX
authors.lastname: Guan
authors.affiliation: Department of Neurology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, China.
authors.forename: Zu-Neng
authors.initials: ZN
authors.lastname: Lu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000821:virology*; D001929:Brain Edema / Q000201:enzymology / Q000517:prevention & control; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D020803:Encephalitis, Herpes Simplex / Q000201:enzymology* / Q000473:pathology; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D005260:Female; D018259:Herpesvirus 1, Human / Q000472:pathogenicity; D053208:Kaplan-Meier Estimate; D007701:Kinetin / Q000008:administration & dosage*; D051379:Mice; D008807:Mice, Inbred BALB C; D017628:Microglia / Q000187:drug effects / Q000201:enzymology; D014759:Viral Envelope Proteins / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D014759:Viral Envelope Proteins; C039447:glycoprotein D, Human herpesvirus 1; C090046:olomoucine; D018844:Cyclin-Dependent Kinases; D007701:Kinetin
keywords: Cyclin-dependent kinases; Herpes simplex encephalitis; Inflammation; Microglia