title: Antimycobacterial activity of new N(1)-[1-[1-aryl-3-[4-(1H-imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives.
abstract: N(1)-[1-[1-aryl-3-[4-(1H-imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives were design, synthesized and tested for their in vitro antimycobacterial activity. The new compounds showed a moderate antimycobacterial activity against the tested strain of Mycobacterium tuberculosis H37Ra and a significant antimycobacterial activity against several mycobacteria other than tuberculosis strains.
authors.affiliation: Department of Chemistry and Pharmaceutical Sciences, Piazzale Europa 1, University of Trieste, 34127 Trieste, Italy. Electronic address: dzampieri@units.it.
authors.forename: Daniele
authors.initials: D
authors.lastname: Zampieri
authors.affiliation: Department of Chemistry and Pharmaceutical Sciences, Piazzale Europa 1, University of Trieste, 34127 Trieste, Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Mamolo
authors.affiliation: Department of Chemistry and Pharmaceutical Sciences, Piazzale Europa 1, University of Trieste, 34127 Trieste, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Vio
authors.affiliation: Department of Life Sciences, Via Valerio 28/1, University of Trieste, 34127 Trieste, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Romano
authors.affiliation: ICGEB, International Centre for Genetic Engeneering and Biootechnology, Padriciano 99, 34149 Trieste, Italy.
authors.forename: Nataša
authors.initials: N
authors.lastname: Skoko
authors.affiliation: ICGEB, International Centre for Genetic Engeneering and Biootechnology, Padriciano 99, 34149 Trieste, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Baralle
authors.affiliation: Department of Life and Enviromental Sciences, Via Porcell 4, University of Cagliari, 09124 Cagliari, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Pau
authors.affiliation: Department of Life and Enviromental Sciences, Via Porcell 4, University of Cagliari, 09124 Cagliari, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: De Logu
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000187:drug effects*; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007093:Imidazoles; D011725:Pyridines
keywords: Antimycobacterial activity; Mycobacteria other than tuberculosis (MOTT); Pyridine-2-carboxamidrazone derivatives