title: [Pharmacokinetic Study on Brucine in Different Administration Methods of Liposome in Rats].
abstract: OBJECTIVE
  To compare the pharmacokinetic differences of brucine in rats after different administration methods of brucine liposome.
  
  
  METHODS
  To determine brucine in rat plasma at different points in time by HPLC after oral administration, intramuscular injection, subcutaneous injection and intravenous injection of brucine liposome, respectively. The pharmacokinetic parameters were calculated and analyzed by DAS 3.0.
  
  
  RESULTS
  Compared with other groups, AUC(0 --> t) of subcutaneous injection were higher, C(max) were lower and MRT(0 --> 1), were significantly improved. The pharmacokinetics parameters and absolute bioavailability of brucine show that bioavailability in rats after different administration methods of brucine liposome is subcutaneous injection > intramuscular injection > oral administration.
authors.forename: Ruo-xuan
authors.initials: RX
authors.lastname: Liu
authors.forename: Li-ming
authors.initials: LM
authors.lastname: Li
authors.forename: Fei
authors.initials: F
authors.lastname: Wu
authors.forename: A-rong
authors.initials: AR
authors.lastname: Li
authors.forename: Xia-wen
authors.initials: XW
authors.lastname: Liu
authors.forename: Jie-wen
authors.initials: JW
authors.lastname: Guo
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008081:Liposomes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013331:Strychnine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D008081:Liposomes; C083806:brucine; D013331:Strychnine