title: Recent advances in dynamic m6A RNA modification.
abstract: The identification of m(6)A demethylases and high-throughput sequencing analysis of methylated transcriptome corroborated m(6)A RNA epigenetic modification as a dynamic regulation process, and reignited its investigation in the past few years. Many basic concepts of cytogenetics have been revolutionized by the growing understanding of the fundamental role of m(6)A in RNA splicing, degradation and translation. In this review, we summarize typical features of methylated transcriptome in mammals, and highlight the 'writers', 'erasers' and 'readers' of m(6)A RNA modification. Moreover, we emphasize recent advances of biological functions of m(6)A and conceive the possible roles of m(6)A in the regulation of immune response and related diseases.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Guangchao
authors.initials: G
authors.lastname: Cao
authors.affiliation: Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA.
authors.forename: Hua-Bing
authors.identifier: http://orcid.org/0000-0003-3573-6803
authors.initials: HB
authors.lastname: Li
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, People's Republic of China The First Affiliated Hospital, Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou 510632, People's Republic of China zhinan.yin@yale.edu.
authors.forename: Zhinan
authors.initials: Z
authors.lastname: Yin
authors.affiliation: Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA richard.flavell@yale.edu.
authors.forename: Richard A
authors.identifier: http://orcid.org/0000-0003-4461-0778
authors.initials: RA
authors.lastname: Flavell
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D006801:Humans; D007109:Immunity; D008745:Methylation; D012313:RNA / Q000378:metabolism*; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D012313:RNA; D000241:Adenosine
keywords: m6A; mRNA; methylation