title: Data set of interactomes and metabolic pathways of proteins differentially expressed in brains with Alzheimer׳s disease.
abstract: Alzheimer׳s disease is one of the main causes of dementia in the elderly and its frequency is on the rise worldwide. It is considered the result of complex interactions between genetic and environmental factors, being many of them unknown. Therefore, there is a dire necessity for the identification of novel molecular players for the understanding of this disease. In this data article we determined the protein expression profiles of whole protein extracts from cortex regions of brains from patients with Alzheimer׳s disease in comparison to a normal brain. We identified 721 iTRAQ-labeled polypeptides with more than 95% in confidence. We analyzed all proteins that changed in their expression level and located them in the KEGG metabolic pathways, as well as in the mitochondrial complexes of the electron transport chain and ATP synthase. In addition, we analyzed the over- and sub-expressed polypeptides through IPA software, specifically Core I and Biomarkers I modules. Data in this article is related to the research article "Identification of proteins that are differentially expressed in brains with Alzheimer's disease using iTRAQ labeling and tandem mass spectrometry" (Minjarez et al., 2016) [1].
authors.affiliation: Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Gustavo A. Madero, C.P. 07360 Ciudad de México, México; Departamento de Biología Celular y Molecular, Centro Universitario de Ciencias Biológicas y Agropecuarias (CUCBA), Universidad de Guadalajara, Camino Ramón Padilla Sánchez No. 2100, Nextipac, Zapopan, Jalisco, México.
authors.forename: Benito
authors.initials: B
authors.lastname: Minjarez
authors.affiliation: Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Gustavo A. Madero, C.P. 07360 Ciudad de México, México.
authors.forename: Karla Grisel
authors.initials: KG
authors.lastname: Calderón-González
authors.affiliation: Unidad de Proteómica, Centro de Investigación Príncipe Felipe, C/Rambla del Saler 16, 46012 Valencia, España; Secció de Proteómica, Servei Central de Suport a la Investigació Experimental (SCSIE), Universitat de València, C/Doctor Moliner 50, 46100 Burjassot, València, España.
authors.forename: Ma Luz
authors.initials: ML
authors.lastname: Valero Rustarazo
authors.affiliation: Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Gustavo A. Madero, C.P. 07360 Ciudad de México, México.
authors.forename: María Esther
authors.initials: ME
authors.lastname: Herrera-Aguirre
authors.affiliation: Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Gustavo A. Madero, C.P. 07360 Ciudad de México, México.
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Labra-Barrios
authors.affiliation: Departments of Neurology and Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA.
authors.forename: Diego E
authors.initials: DE
authors.lastname: Rincon-Limas
authors.affiliation: Unidad de Proteómica, Centro de Investigación Príncipe Felipe, C/Rambla del Saler 16, 46012 Valencia, España; Departament de Bioquímica i Biologia Molecular, Facultat de Ciències Biològiques, Universitat de València, C/ Doctor Moliner 50, 46100 Burjassot, València, España.
authors.forename: Manuel M
authors.initials: MM
authors.lastname: Sánchez Del Pino
authors.affiliation: Departamento de Fisiología, Biofísica y Neurociencias, Cinvestav-IPN, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Gustavo A. Madero, C.P. 07360 Ciudad de México, México.
authors.forename: Raul
authors.initials: R
authors.lastname: Mena
authors.affiliation: Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, Gustavo A. Madero, C.P. 07360 Ciudad de México, México.
authors.forename: Juan Pedro
authors.initials: JP
authors.lastname: Luna-Arias