title: Distinct temporal spike and local field potential activities in the thalamic parafascicular nucleus of parkinsonian rats during rest and limb movement.
abstract: Several studies have suggested that the thalamic centromedian-parafascicular (CM/PF or the PF in rodents) is implicated in the pathophysiology of Parkinson's disease (PD). However, inconsistent changes in the neuronal firing rate and pattern have been reported in parkinsonian animals. To investigate the impact of a dopaminergic cell lesion on PF extracellular discharge in behaving rats, the PF neural activities in the spike and local field potential (LFP) were recorded in unilaterally 6-hydroxydopamine- (6-OHDA) lesioned and neurologically intact control rats during rest and limb movement. During rest, the two PF neuronal subtypes was less spontaneously active, with no difference in the spike firing rates between the control and lesioned rats; only the lesioned rats reshaped their spike firing pattern. Furthermore, the simultaneously recorded LFP in the lesioned rats exhibited a significant increase in power at 12-35 and 35-70Hz and a decrease in power at 0.7-12Hz. During the execution of a voluntary movement, two subtypes of PF neurons were identified by a rapid increase in the discharge activity in both the control and lesioned rats. However, dopamine lesioning was associated with a decrease in neuronal spiking fire rate and reshaping in the firing pattern in the PF. The simultaneously recorded LFP activity exhibited a significant increase in power at 12-35Hz and a decrease in power at 0.7-12Hz compared with the control rats. These findings indicate that 6-OHDA induces modifications in PF spike and LFP activities in rats during rest and movement and suggest that PF dysfunction may be an important contributor to the pathophysiology of parkinsonian motor impairment.
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China. Electronic address: wangmin78@yahoo.com.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Qingyang
authors.initials: Q
authors.lastname: Qu
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Tingting
authors.initials: T
authors.lastname: He
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: Center for Behavioral Neuroscience, Neuroscience Institute, Georgia State University, Atlanta, GA 30302, United States.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Song
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Feiyu
authors.initials: F
authors.lastname: Chen
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Jinlu
authors.initials: J
authors.lastname: Xie
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Xiwen
authors.initials: X
authors.lastname: Geng
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Maoquan
authors.initials: M
authors.lastname: Yang
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Xiusong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Chengdong
authors.initials: C
authors.lastname: Lei
authors.affiliation: Key Laboratory of Animal Resistance of Shandong Province, College of Life Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Yabing
authors.initials: Y
authors.lastname: Hou
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004298:Dopamine / Q000378:metabolism; D007839:Functional Laterality; D007150:Immunohistochemistry; D020646:Intralaminar Thalamic Nuclei / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008839:Microelectrodes; D009043:Motor Activity / Q000502:physiology*; D009474:Neurons / Q000473:pathology / Q000502:physiology*; D016627:Oxidopamine; D020734:Parkinsonian Disorders / Q000473:pathology / Q000503:physiopathology*; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D016627:Oxidopamine; D004298:Dopamine
keywords: Parkinson’s disease; extracellular recording; local field potential; microelectrode; spike; thalamic parafascicular nucleus