title: Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
abstract: The mammalian target of rapamycin (mTOR) is a central regulator of gene expression, translation and various metabolic processes. Multiple extracellular (growth factors) and intracellular (energy status) molecular signals as well as a variety of stressors are integrated into the mTOR pathway. Viral infection is a significant stress that can activate, reduce or even suppress the mTOR signaling pathway. Consequently, viruses have evolved a plethora of different mechanisms to attack and co-opt the mTOR pathway in order to make the host cell a hospitable environment for replication. A more comprehensive knowledge of different viral interactions may provide fruitful targets for new antiviral drugs.
authors.affiliation: HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General Hospital, Montréal, QC H3T 1E2, Canada. vle_sage@hotmail.com.
authors.forename: Valerie
authors.initials: V
authors.lastname: Le Sage
authors.affiliation: HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General Hospital, Montréal, QC H3T 1E2, Canada. alessandro.cinti@mail.mcgill.ca.|Department of Medicine, McGill University, Montréal, QC H3A 0G4, Canada. alessandro.cinti@mail.mcgill.ca.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cinti
authors.affiliation: HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General Hospital, Montréal, QC H3T 1E2, Canada. raquel.amorim@mail.mcgill.ca.|Department of Medicine, McGill University, Montréal, QC H3A 0G4, Canada. raquel.amorim@mail.mcgill.ca.
authors.forename: Raquel
authors.initials: R
authors.lastname: Amorim
authors.affiliation: HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General Hospital, Montréal, QC H3T 1E2, Canada. andrew.mouland@mcgill.ca.|Department of Medicine, McGill University, Montréal, QC H3A 0G4, Canada. andrew.mouland@mcgill.ca.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Mouland
mesh_terms: D000818:Animals; D004267:DNA Viruses / Q000472:pathogenicity / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D012328:RNA Viruses / Q000472:pathogenicity / Q000502:physiology*; D015398:Signal Transduction; D013312:Stress, Physiological; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D058570:TOR Serine-Threonine Kinases
keywords: 4EBP1; Akt; PI3K; autophagy; mTOR; virus