title: Synthesis of pogostone by one-step.
abstract: Pogostone, isolated from Pogostemon cablin, has many biological activities such as potential antibacterial, anticandida, and antifungal. Traditional extraction leads to low output of PO about 17.6 mg/kg from Herba Pogostemonis. The previous literature had reported a synthetic study and the yield had reached 4.48% with strictly controlled reaction conditions. The two methods above cannot meet the large demand of PO; we report a new synthesis method. 4-hydroxy-6-methyl-2-pyrone (1) was added in toluene, with the existence of acylation catalyst 4-dimethylaminopyridine (DMAP), 4-methylvaleric acid (2), and condensing agent dicyclohexylcarbodiimide (DCC), PO was synthesized after the combination of 3-carbon of (1) with 1-OH of (2) in the acylation reaction. The purity had reached 98%, determined by HPLC. The structure was confirmed by spectroscopic methods including infrared, electron ionization mass spectrometry, and nuclear magnetic resonance spectroscopy. PO was totally synthesized in one step including cyclization, with total yield of 27.2%.
authors.affiliation: a The First Affiliated Hospital of Chinese Medicine , Guangzhou University of Chinese Medicine , Guangzhou 510405 , China.|c Guangdong Provincial Key Laboratory of New Chinese Medicinals Development and Research , Guangzhou University of Chinese Medicine , Guangzhou 510405 , China.
authors.forename: Han-Bin
authors.initials: HB
authors.lastname: Chen
authors.affiliation: b School of Chinese Materia Medica , Guangzhou University of Chinese Medicine , Guangzhou 510006 , China.|c Guangdong Provincial Key Laboratory of New Chinese Medicinals Development and Research , Guangzhou University of Chinese Medicine , Guangzhou 510405 , China.
authors.forename: Jiang-Tao
authors.initials: JT
authors.lastname: Zhou
authors.affiliation: b School of Chinese Materia Medica , Guangzhou University of Chinese Medicine , Guangzhou 510006 , China.|c Guangdong Provincial Key Laboratory of New Chinese Medicinals Development and Research , Guangzhou University of Chinese Medicine , Guangzhou 510405 , China.
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Liu
authors.affiliation: b School of Chinese Materia Medica , Guangzhou University of Chinese Medicine , Guangzhou 510006 , China.|c Guangdong Provincial Key Laboratory of New Chinese Medicinals Development and Research , Guangzhou University of Chinese Medicine , Guangzhou 510405 , China.
authors.forename: Zhen-Biao
authors.initials: ZB
authors.lastname: Zhang
authors.affiliation: b School of Chinese Materia Medica , Guangzhou University of Chinese Medicine , Guangzhou 510006 , China.|c Guangdong Provincial Key Laboratory of New Chinese Medicinals Development and Research , Guangzhou University of Chinese Medicine , Guangzhou 510405 , China.
authors.forename: Ya-Xian
authors.initials: YX
authors.lastname: Zhan
authors.affiliation: b School of Chinese Materia Medica , Guangzhou University of Chinese Medicine , Guangzhou 510006 , China.|c Guangdong Provincial Key Laboratory of New Chinese Medicinals Development and Research , Guangzhou University of Chinese Medicine , Guangzhou 510405 , China.
authors.forename: Zi-Ren
authors.initials: ZR
authors.lastname: Su
authors.affiliation: a The First Affiliated Hospital of Chinese Medicine , Guangzhou University of Chinese Medicine , Guangzhou 510405 , China.|c Guangdong Provincial Key Laboratory of New Chinese Medicinals Development and Research , Guangzhou University of Chinese Medicine , Guangzhou 510405 , China.
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Zeng
mesh_terms: D015761:4-Aminopyridine / Q000031:analogs & derivatives / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009822:Oils, Volatile / Q000138:chemical synthesis* / Q000737:chemistry; D000070177:Pogostemon / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile; C483658:Pogostone; D011753:Pyrones; D015761:4-Aminopyridine; C003885:4-dimethylaminopyridine; C525072:4-hydroxy-6-methyl-2-pyrone
keywords: Pogostone; one step; synthesis