title: Silver(I) 1,3,5-Triaza-7-phosphaadamantane Coordination Polymers Driven by Substituted Glutarate and Malonate Building Blocks: Self-Assembly Synthesis, Structural Features, and Antimicrobial Properties.
abstract: Three new bioactive silver(I) coordination polymers formulated as [Ag2(μ2-PTA)(μ3-PTA)(μ2-pga)(H2O)]n·6H2O (1), [Ag2(μ2-PTA)(μ3-PTA)(Hpmal)2]n·2H2O (2), and [Ag(μ3-PTA) (Hdmga)]n (3) were self-assembled from Ag2O, 1,3,5-triaza-7-phosphaadamantane (PTA), and a substituted dicarboxylic acid (3-phenylglutaric acid (H2pga), phenylmalonic acid (H2pmal), or 3,3-dimethylglutaric acid (H2dmga)) as an ancillary ligand. Compounds 1-3 were fully characterized by IR and NMR spectroscopy, ESI-MS(±), elemental analysis, and single-crystal X-ray diffraction, revealing that their architectural and topological diversity is governed by structural modulation of a dicarboxylate building block. The structures vary from a 1D cyclic chain with the SP 1-periodic net (4,4)(0,2) topology in 2 to distinct 2D metal-organic layers with the cem-d and hcb topologies in 1 and 3, respectively. In addition, compounds 1-3 exhibit a notable antimicrobial efficiency against a panel of common Gram-negative (E. coli and P. aeruginosa) and Gram-positive (S. aureus) bacteria and yeast (C. albicans). The best normalized minimum inhibitory concentrations (normalized MIC) of 11-23 nmol mL(-1) (for bacterial strains) or 68 nmol mL(-1) (for a yeast strain) are shown by compound 2, and the eventual structure-bioactivity correlations are discussed.
authors.affiliation: Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Universidade de Lisboa , Av. Rovisco Pais, 1049-001 Lisbon, Portugal.
authors.forename: Sabina W
authors.initials: SW
authors.lastname: Jaros
authors.affiliation: Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Universidade de Lisboa , Av. Rovisco Pais, 1049-001 Lisbon, Portugal.
authors.forename: M Fátima C
authors.initials: MF
authors.lastname: Guedes da Silva
authors.affiliation: Department of Pathology, Wrocław University of Environmental and Life Sciences , ul. Norwida 31, 50-375 Wrocław, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Florek
authors.affiliation: Faculty of Chemistry, University of Wrocław , ul. F. Joliot-Curie 14, 50-383 Wrocław, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Smoleński
authors.affiliation: Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Universidade de Lisboa , Av. Rovisco Pais, 1049-001 Lisbon, Portugal.
authors.forename: Armando J L
authors.initials: AJ
authors.lastname: Pombeiro
authors.affiliation: Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Universidade de Lisboa , Av. Rovisco Pais, 1049-001 Lisbon, Portugal.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Kirillov
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000737:chemistry; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D005977:Glutarates / Q000737:chemistry*; D008314:Malonates / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009943:Organophosphorus Compounds / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods
chemical_list: C501763:1,3,5-triaza-7-phosphaadamantane; D000890:Anti-Infective Agents; D056831:Coordination Complexes; D005977:Glutarates; D008314:Malonates; D009943:Organophosphorus Compounds; D011108:Polymers; D012834:Silver; C030290:malonic acid; C035736:glutaric acid; D000218:Adamantane