title: ABO blood groups in relation to breast carcinoma incidence and associated prognostic factors in Moroccan women.
abstract: The association between blood groups ABO and different types of diseases was established in several previous studies. Our aim was to seek the possible association between the ABO blood group and breast cancer-associated prognostic factors. The Chi-squared analytic test was used to compare phenotypic ABO distribution among Moroccan blood donors and 442 cases of women suffering from breast carcinoma with archived files in Maternity Ward of University Hospital C.H.U Ibn Rochd between 2008 and 2011. High incidence of breast carcinoma was observed in blood type B patients (p < 0.05). Blood type B was associated with breast carcinomas overexpressing human epidermal growth factor receptor HER2 (p < 0.05) and high risk of cancer at age over 70 years (p < 0.001). Blood type A was associated with high risk of cancer among women younger than 35 years old. Blood type A and AB were associated with high incidence of lymph node metastasis (p < 0.05). Multivariate analysis has shown correlation between O blood type and estrogen receptor-positive tumor. Patients with blood group A, B, and AB were more likely to develop aggressive breast carcinoma. Further follow-up studies are necessary to clarify the role of ABH antigens in the progression of breast carcinoma.
authors.affiliation: Laboratory of Biotechnology and Experimental Medicine, Faculty of Medicine and Pharmacy Casablanca, Hassan II University of Casablanca, 19 Rue Tarik Ibnou Ziad, B.P. 9154, 20000, Casablanca, Morocco. soukaina.zouine@gmail.com.|Laboratory of Hematology, Cellular and Genetic Engineering, Faculty of Medicine and Pharmacy Casablanca, Hassan II University of Casablanca, Casablanca, Morocco. soukaina.zouine@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Zouine
authors.affiliation: Pathology Department, University Hospital Ibn Rochd Casablanca, Casablanca, Morocco.
authors.forename: F
authors.initials: F
authors.lastname: Marnissi
authors.affiliation: Laboratory of Medical Informatics, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Casablanca, Morocco.
authors.forename: N
authors.initials: N
authors.lastname: Otmani
authors.affiliation: Laboratory of Medical Informatics, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Casablanca, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: Bennani Othmani
authors.affiliation: Laboratory of Biotechnology and Experimental Medicine, Faculty of Medicine and Pharmacy Casablanca, Hassan II University of Casablanca, 19 Rue Tarik Ibnou Ziad, B.P. 9154, 20000, Casablanca, Morocco.|Laboratory of Hematology, Cellular and Genetic Engineering, Faculty of Medicine and Pharmacy Casablanca, Hassan II University of Casablanca, Casablanca, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: El Wafi
authors.affiliation: Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, QC, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Kojok
authors.affiliation: Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, QC, Canada.
authors.forename: Y
authors.initials: Y
authors.lastname: Zaid
authors.affiliation: Pathology Laboratory, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca, Casablanca, Morocco.
authors.forename: N
authors.initials: N
authors.lastname: Tahiri Jouti
authors.affiliation: Laboratory of Biotechnology and Experimental Medicine, Faculty of Medicine and Pharmacy Casablanca, Hassan II University of Casablanca, 19 Rue Tarik Ibnou Ziad, B.P. 9154, 20000, Casablanca, Morocco.|Laboratory of Hematology, Cellular and Genetic Engineering, Faculty of Medicine and Pharmacy Casablanca, Hassan II University of Casablanca, Casablanca, Morocco.
authors.forename: N
authors.initials: N
authors.lastname: Habti
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009018:Morocco / Q000453:epidemiology; D010641:Phenotype; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000017:ABO Blood-Group System
keywords: ABO blood group; Age at diagnosis; Breast carcinoma; Estrogen receptor; Human epidermal growth factor receptor 2; Lymph node metastasis