title: LECANDUS study (LEsion CANdidate Detection in UltraSound Data): evaluation of image analysis algorithms for breast lesion detection in volume ultrasound data.
abstract: This study aims at developing and evaluating a prototype of a lesion candidate detection algorithm for a 3D-US computer-aided diagnosis (CAD) system.
  
  
  
  Additionally, to routine imaging, automated breast volume scans (ABVS) were performed on 63 patients. All ABVS exams were analyzed and annotated before the evaluation with different algorithm blob detectors characterized by different blob-radiuses, voxel-sizes and the quantiles of blob filter responses to find lesion candidates. Lesions found in candidates were compared to the prior annotations.
  
  
  
  All histologically proven lesions were detected with at least one algorithm. The algorithm with optimal sensitivity detected all cancers (sensitivity = 100 %) with a very low positive predictive value due to a high false-positive rate.
  
  
  
  ABVS is a new technology which can be analyzed by a CAD software. Using different algorithms, lesions can be detected with a very high and accurate sensitivity. Further research for feature extraction and lesion classification is needed aiming at reducing the false-positive hits.
authors.affiliation: University Breast Unit, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany. Michael.Golatta@med.uni-heidelberg.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Golatta
authors.affiliation: University Breast Unit, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
authors.forename: Désirée
authors.initials: D
authors.lastname: Zeegers
authors.affiliation: MeVis BreastCare Solutions GmbH & Co. KG A MeVis Medical Solutions Company, Universitaetsallee 29, 28359, Bremen, Germany.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Filippatos
authors.affiliation: University Breast Unit, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
authors.forename: Leah-Larissa
authors.initials: LL
authors.lastname: Binder
authors.affiliation: University Breast Unit, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Scharf
authors.affiliation: Institute of Medical Biometry and Informatics, University of Heidelberg, 69120, Heidelberg, Germany.
authors.forename: Geraldine
authors.initials: G
authors.lastname: Rauch
authors.affiliation: University Breast Unit, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Rom
authors.affiliation: University Breast Unit, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Schütz
authors.affiliation: University Breast Unit, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
authors.forename: Christof
authors.initials: C
authors.lastname: Sohn
authors.affiliation: University Breast Unit, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
authors.forename: Joerg
authors.initials: J
authors.lastname: Heil
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement; D021621:Imaging, Three-Dimensional / Q000379:methods*; D012680:Sensitivity and Specificity; D012984:Software; D014463:Ultrasonography / Q000379:methods*
keywords: 3D-scanning; Blob detector; Breast; CAD (Computer-aided diagnosis); Ultrasound