title: Higher Carotid Intima-Media Thickness in Subclinical Hypothyroidism Associated with the Metabolic Syndrome.
abstract: The subclinical hypothyroidism (SH) and the metabolic syndrome (MS) have been associated with increased risk of atherosclerosis and cardiovascular disease (CVD). The measurement of carotid intima-media thickness (IMT) is capable of detecting early signs of atherosclerotic disease. The goal of the study was to compare the carotid IMT of patients with SH with and without the MS.
  
  
  
  Twenty-nine SH patients were subdivided into two groups: one with MS (SH + MS) and one without MS (SH - MS). The study also assessed a group of euthyroid patients (n = 31), also subdivided into two groups: one with MS (EU + MS) and one without MS (EU - MS). The clinical and laboratory data and the mean and maximum carotid IMT of the groups were compared.
  
  
  
  Maximum (P = 0.012) and mean (P = 0.025) IMT were higher in the SH + MS group than in the SH-MS group. Maximum IMT was higher in the SH + MS group than in the EU + MS group (P = 0.048). Maximum IMT was positively correlated with fasting glucose (FG; R = 0.621; P < 0.01) and body mass index (R = 0.258; P = 0.041) and negatively correlated with low-density lipoprotein cholesterol (LDL-C) (R = -0.297; P = 0.017). Mean IMT was positively correlated with FG (R = 0.580; P < 0.01), systolic blood pressure (R = 0.292; P = 0.02), and triglycerides (R = 0.250; P = 0.048) and negatively correlated with LDL-C (R = -0.288; P = 0.022).
  
  
  
  SH + MS patients have higher IMT than SH - MS or EU + MS patients, suggesting that SH may be one more CVD risk factor in patients with the MS.
authors.affiliation: 1 Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University , UNESP, Botucatu, Brazil .
authors.forename: Mariana Martins
authors.initials: MM
authors.lastname: França
authors.affiliation: 1 Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University , UNESP, Botucatu, Brazil .
authors.forename: Célia Regina
authors.initials: CR
authors.lastname: Nogueira
authors.affiliation: 1 Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University , UNESP, Botucatu, Brazil .
authors.forename: João Carlos
authors.initials: JC
authors.lastname: Hueb
authors.affiliation: 1 Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University , UNESP, Botucatu, Brazil .
authors.forename: Adriana Lúcia
authors.initials: AL
authors.lastname: Mendes
authors.affiliation: 2 Department of Biostatistics, Biosciences Institute, Sao Paulo State University , UNESP, Botucatu, Brazil .
authors.forename: Carlos Roberto
authors.initials: CR
authors.lastname: Padovani
authors.affiliation: 1 Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University , UNESP, Botucatu, Brazil .
authors.forename: Gláucia Maria Ferreira da Silva
authors.initials: GM
authors.lastname: Mazeto
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000150:complications / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000000981:diagnostic imaging*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging*; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose
keywords: atherosclerosis; cardiovascular disease; carotid intima-media thickness; hypothyroidism; metabolic syndrome; subclinical hypothyroidism