title: Are inflammatory parameters predictors of amputation in acute arterial occlusions?
abstract: Background The aim of the present study was to investigate the role of inflammatory markers to predict amputation following embolectomy in acute arterial occlusion. Methods A total of 123 patients operated for arterial thromboembolectomy due to acute embolism were included in the study. The patients without an extremity amputation following thromboembolectomy were classified as Group 1 ( n = 91) and the rest were classified as Group 2 ( n = 32). These groups were compared in terms of clinical and demographic characteristics, C-reactive protein, complete blood count parameters, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and red cell distribution width. Results The average age was 68.0 ± 11.7 years. The most common thromboembolism localization was femoral artery. When preoperative mean C-reactive protein ( p = 0.0001), mean platelet volume ( p = 0.0001), platelet-lymphocyte ratio ( p = 0.0001), neutrophil-lymphocyte ratio ( p = 0.0001) and red cell distribution width ( p = 0.0001) were compared, a statistically significant difference was observed between groups. In univariate and multivariate regression analysis, higher levels of preoperative C-reactive protein ( p = 0.009) and mean platelet volume ( p = 0.04) were detected as independent risk factors of early extremity amputation. Conclusion We observed that preoperative mean platelet volume and C-reactive protein were predictors of amputation after thromboembolectomy in acute arterial occlusion.
authors.affiliation: 1 Clinic of Cardiovascular Surgery, Derince Education and Research Hospital, Kocaeli, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Saskin
authors.affiliation: 2 Clinic of Cardiology, Derince Education and Research Hospital, Kocaeli, Turkey.
authors.forename: Kazim S
authors.initials: KS
authors.lastname: Ozcan
authors.affiliation: 1 Clinic of Cardiovascular Surgery, Derince Education and Research Hospital, Kocaeli, Turkey.
authors.forename: Cagri
authors.initials: C
authors.lastname: Duzyol
authors.affiliation: 1 Clinic of Cardiovascular Surgery, Derince Education and Research Hospital, Kocaeli, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Baris
authors.affiliation: 3 Clinic of Cardiovascular Surgery, Siyami Ersek Thoracic and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey.
authors.forename: Uğur C
authors.initials: UC
authors.lastname: Koçoğulları
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D019540:Area Under Curve; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D017128:Embolectomy / Q000009:adverse effects*; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D023821:Limb Salvage; D016015:Logistic Models; D018655:Lymphocyte Count; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils; D016017:Odds Ratio; D010976:Platelet Count; D011237:Predictive Value of Tests; D012372:ROC Curve; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein
keywords: Acute arterial occlusion; amputation; biomarkers