title: Glaucoma as a Neurodegenerative Disease: Why We Must 'Look for the Protein'.
abstract: For years, clinicians and scientists interested in glaucoma have focused on the anterior segment of the eye and lowering of the intraocular pressure with respect to glaucoma causes and therapies. Yet glaucoma progresses in many individuals despite lowering the intraocular pressure. Herein, the concept of glaucoma as a neurodegenerative disease is presented. [Full article available at http://rimed.org/rimedicaljournal-2016-06.asp, free with no login].
authors.affiliation: Professor of Surgery (Ophthalmology), Deputy Chief of Ophthalmology, Alpert Medical School of Brown University; Rhode Island Hospital, Providence, RI.
authors.forename: Lenworth N
authors.initials: LN
authors.lastname: Johnson
mesh_terms: D000199:Actins / Q000378:metabolism; D015894:Genome, Human; D005901:Glaucoma / Q000235:genetics* / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000503:physiopathology*; D018911:Trinucleotide Repeats
chemical_list: D000199:Actins
keywords: Alzheimer disease; DNA trinucleotide repeat; Huntington disease; actin; cortactin; cytoskeletal protein; glaucoma; human genome; intraocular pressure; neurodegenerative disease; optic neuropathy