title: Effects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects.
abstract: BACKGROUND
  Hypertension, hypercholesterolemia, and obesity increase the risk of dementia. Although their detection is commonly followed by an introduction of treatment, little is known about how medications frequently used to treat vascular risk affect amyloid deposition.
  
  
  METHODS
  A cross-sectional study of 156 subjects who underwent positron emission tomography with PiB. Using linear regression, we tested whether blood pressure, cholesterol, overweight/obese status, angiotensin receptor blockers (ARBs), beta-blockers, diuretics, angiotensin converting enzyme inhibitors, and statins predicted amyloid deposition.
  
  
  RESULTS
  The use of ARBs (β = -.15, P = .044) and diuretics (β = -.20, P = .006) predicted less amyloid accumulation; older age (β = .29, P < .001) and statins (β = .23, P = .004) were related to greater amyloid deposition. Overweight and/or obese women had more cortical amyloid than their peers.
  
  
  CONCLUSIONS
  Prospective studies should confirm effects of drugs and increased body weight on amyloid accumulation and establish whether they translate into measurable clinical outcomes. Women may be more susceptible to harmful effects of obesity.
authors.affiliation: Department of Psychiatry, Center for Brain Health, NYU School of Medicine, New York, USA; Department of Radiology, NYU School of Medicine, New York, USA.
authors.forename: Lidia
authors.initials: L
authors.lastname: Glodzik
authors.affiliation: Department of Radiology, NYU School of Medicine, New York, USA.
authors.forename: Henry
authors.initials: H
authors.lastname: Rusinek
authors.affiliation: Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York, USA.
authors.forename: Angela
authors.initials: A
authors.lastname: Kamer
authors.affiliation: Department of Psychiatry, Center for Brain Health, NYU School of Medicine, New York, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Pirraglia
authors.affiliation: Department of Psychiatry, Center for Brain Health, NYU School of Medicine, New York, USA.
authors.forename: Wai
authors.initials: W
authors.lastname: Tsui
authors.affiliation: Department of Psychiatry, Center for Brain Health, NYU School of Medicine, New York, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Mosconi
authors.affiliation: Department of Psychiatry, Center for Brain Health, NYU School of Medicine, New York, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Psychiatry, Center for Brain Health, NYU School of Medicine, New York, USA.
authors.forename: Pauline
authors.initials: P
authors.lastname: McHugh
authors.affiliation: Department of Psychiatry, Center for Brain Health, NYU School of Medicine, New York, USA.
authors.forename: John
authors.initials: J
authors.lastname: Murray
authors.affiliation: Renal Research Institute, New York, USA.
authors.forename: Schantel
authors.initials: S
authors.lastname: Williams
authors.affiliation: Department of Psychiatry, Center for Brain Health, NYU School of Medicine, New York, USA.
authors.forename: Ricardo S
authors.initials: RS
authors.lastname: Osorio
authors.affiliation: Department of Psychiatry, Center for Brain Health, NYU School of Medicine, New York, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Randall
authors.affiliation: Department of Psychiatry, Center for Brain Health, NYU School of Medicine, New York, USA.
authors.forename: Tracy
authors.initials: T
authors.lastname: Butler
authors.affiliation: Department of Psychiatry, Center for Brain Health, NYU School of Medicine, New York, USA.
authors.forename: Anup
authors.initials: A
authors.lastname: Deshpande
authors.affiliation: Department of Radiology, Weill Cornell Medical College, New York, USA.
authors.forename: Shankar
authors.initials: S
authors.lastname: Vallabhajolusa
authors.affiliation: Department of Psychiatry, Center for Brain Health, NYU School of Medicine, New York, USA.
authors.forename: Mony
authors.initials: M
authors.lastname: de Leon
keywords: Amyloid; Antihypertensive medications; Brain; Diuretics; Healthy elderly; PET-PiB; Statins angiotensin receptor blockers; Vascular risk factors