title: Interleukin-1 Inhibition in Behçet's disease.
abstract: Behçet's disease (BD) is a systemic inflammatory disorder characterized by a protean clinical spectrum and an enigmatic pathogenesis. After being classified as an autoimmune disorder, spondyloarthritis and vasculitis, today BD is considered at the crossroad between autoimmune and auto-inflammatory syndromes. Many pathogenetic, clinical and therapeutic clues support this recent interpretation, enabling novel treatment choices such as interleukin (IL)-1 inhibition. Thus, in the last decade the IL-1 receptor antagonist anakinra and the anti-IL-1β monoclonal antibody canakinumab were increasingly administered in BD patients resistant to standard therapies, leading to interesting results and intriguing new pathogenetic implications. However, further studies are essential to both establish how the innate and acquired immune systems interact in BD patients and identify the best way of administering anti-IL-1 agents with regard to dosage, interval of administration, and organ response.
authors.forename: Antonio
authors.initials: A
authors.lastname: Vitale
authors.forename: Donato
authors.initials: D
authors.lastname: Rigante
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lopalco
authors.forename: Carlo
authors.initials: C
authors.lastname: Selmi
authors.forename: Mauro
authors.initials: M
authors.lastname: Galeazzi
authors.forename: Florenzo
authors.initials: F
authors.lastname: Iannone
authors.forename: Luca
authors.initials: L
authors.lastname: Cantarini
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology / Q000494:pharmacology; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents / Q000276:immunology / Q000494:pharmacology; D015551:Autoimmunity / Q000187:drug effects; D001528:Behcet Syndrome / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D053590:Interleukin 1 Receptor Antagonist Protein / Q000276:immunology / Q000494:pharmacology; D007375:Interleukin-1 / Q000037:antagonists & inhibitors*; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; C541220:canakinumab