title: Effectiveness and safety of Mobi-C for treatment of single-level cervical disc spondylosis: a randomised control trial with a minimum of five years of follow-up.
abstract: OBJECTIVE
  In order to evaluate the effectiveness of the Mobi-C implant in cervical disc degeneration, a randomised study was conducted, comparing the Mobi-C prosthesis arthroplasty with anterior cervical disc fusion (ACDF) in patients with single level cervical spondylosis.
  
  
  METHODS
  From January 2008 to July 2009, 99 patients were enrolled and randomly divided into two groups, those having a Mobi-C implant (n = 51; 30 men, 21 women) and those undergoing ACDF (n = 48; 28 men, 20 women).The patients were followed up for five years, with the primary outcomes being the Japanese Orthopaedic Association score, visual analogue scale for pain and the incidence of further surgery. The secondary outcomes were the Neck Disability Index and range of movement (ROM) of the treated segment.
  
  
  RESULTS
  The incidence of further surgery was found to be statistically significant between the two groups (p = 0.49), with seven ACDF patients requiring further surgery and only one Mobi-C patient requiring re-operation. There were significant differences (p < 0.001) between the two groups in the ROM of the treated segment. However, both Mobi-C surgery and ACDF surgery were effective in improving the patient's clinical symptoms.
  
  
  CONCLUSIONS
  Mobi-C implant surgery is a safe alternative to ACDF surgery in cervical disc degeneration. Cite this article: Bone Joint J 2016;98-B:829-3.
authors.affiliation: Qilu Hospital of Shandong University, 107 Wenhua W Road, Jinan, Shandong 250012, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Qilu Hospital of Shandong University, 107 Wenhua W Road, Jinan, Shandong 250012, China.
authors.forename: L
authors.initials: L
authors.lastname: Nie
authors.affiliation: Qilu Hospital of Shandong University, 107 Wenhua W Road, Jinan, Shandong 250012, China.
authors.forename: X
authors.initials: X
authors.lastname: Pan
authors.affiliation: Qilu Hospital of Shandong University, 107 Wenhua W Road, Jinan, Shandong 250012, China.
authors.forename: M
authors.initials: M
authors.lastname: Si
authors.affiliation: Qilu Hospital of Shandong University, 107 Wenhua W Road, Jinan, Shandong 250012, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Han
authors.affiliation: Qilu Hospital of Shandong University, 107 Wenhua W Road, Jinan, Shandong 250012, China.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.affiliation: Qilu Hospital of Shandong University, 107 Wenhua W Road, Jinan, Shandong 250012, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhang
mesh_terms: D002574:Cervical Vertebrae / Q000601:surgery*; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007403:Intervertebral Disc / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016059:Range of Motion, Articular; D012086:Reoperation; D055009:Spondylosis / Q000601:surgery*; D059145:Total Disc Replacement / Q000295:instrumentation*; D064232:Visual Analog Scale
keywords: Adjacent cervical disc degeneration; Mobi-C; Randomised control trial; Secondary surgery