title: Dual-responsive aggregation-induced emission-active supramolecular nanoparticles for gene delivery and bioimaging.
abstract: Dual-responsive aggregation-induced emission-active supramolecular fluorescent nanoparticles are reported, which have the ability to undergo a unique morphological transition combining with a cooperative optical variation in response to pH and light stimuli. The dynamic supramolecular nanoparticles show excellent biocompatibility and effective plasmid DNA condensation capability, further achieving efficient in vitro gene delivery and bioimaging.
authors.affiliation: Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. linan466@163.com.
authors.forename: Ruijiao
authors.initials: R
authors.lastname: Dong
authors.forename: Screenath P
authors.initials: SP
authors.lastname: Ravinathan
authors.forename: Lizhe
authors.initials: L
authors.lastname: Xue
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Yingjian
authors.initials: Y
authors.lastname: Zhang
authors.forename: Linzhu
authors.initials: L
authors.lastname: Zhou
authors.forename: Chengxi
authors.initials: C
authors.lastname: Cao
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Zhu
mesh_terms: D004247:DNA / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D018014:Gene Transfer Techniques; D006863:Hydrogen-Ion Concentration; D008027:Light; D046911:Macromolecular Substances / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D061848:Optical Imaging; D010957:Plasmids
chemical_list: D005456:Fluorescent Dyes; D046911:Macromolecular Substances; D004247:DNA