title: [Meta analysis for the anesthesia effect and adverse reactions of etomidate and propofol on  the painless abortion surgery].
abstract: OBJECTIVE
  To evaluate the anesthesia effect of etomidate and propofol on painless abortion surgery.
  
  
  METHODS
  After screening the Cochrane Library, Pubmed, China National Knowledge Infrastructure (CNKI), WANFANG, VIP database, the literatures regarding the anesthesia effect of etomidate and propofol on painless abortion surgery were collected from 1995 to 2014. The randomized controlled trials (RCTs) were selected, the quality evaluation was performed and the data was analyzed by using RevMan5.3 software.
  
  
  RESULTS
  A total of 1 130 patients were included in 9 RCTs. The results of Meta analysis were as follows: the anesthesia induction time in the etomidate group was less than that in propofol group (MD=-0.14, 95% CI -0.24 to -0.04, P=0.004); there were more adverse reactions, such as myoclonus, nausea and vomiting, in the etomidate group compared with the propofol group (P<0.001); the incidence of pain in the etomidate group was less than that in the propofol group (P<0.001); there was no significant difference in the incidence of respiratory depression between the 2 groups (P>0.05); the surgery time, analgesia and duration from withdrawal to the wake-up was not significantly different between the 2 groups (P>0.05).
  
  
  CONCLUSIONS
  Etomidate had a shorter anesthesia induction time than propofol in the painless abortion surgery. The incidence of reverse reactions such as myoclonus, nausea and vomiting, was more common in application of etomidate, whereas the incidence of injection pain was more common in the use of propofol group. There was no significant difference in respiratory depression between the 2 drugs. The comprehensive efficacy of propofol is better than etomidate.
authors.affiliation: Department of Scientific and Research, Xi'an Medical University, Xi'an 710077, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Scientific and Research, Xi'an Medical University, Xi'an 710077, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Scientific and Research, Xi'an Medical University, Xi'an 710077, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Xu
authors.affiliation: Department of Scientific and Research, Xi'an Medical University, Xi'an 710077, China.
authors.forename: Lihui
authors.initials: L
authors.lastname: Long
mesh_terms: D000028:Abortion, Induced; D000758:Anesthesia; D018686:Anesthetics, Intravenous; D002681:China; D005045:Etomidate / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010146:Pain / Q000517:prevention & control; D011247:Pregnancy; D015742:Propofol / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol; D005045:Etomidate