title: A new dihydrofurocoumarin from the fruits of Pandanus tectorius Parkinson ex Du Roi.
abstract: From the fruit of Pandanus tectorius Parkinson ex Du Roi, one new dihydrofurocoumarin, named pandanusin A (1) and 15 known compounds, including one furanocoumarin (2), two coumarins (3, 4), four lignans (5-8), one neolignan (9), two flavonoids (10, 11), three phenolics (12-14), one monoglyceride (15) and one monosaccharide (16) were isolated by various chromatography methods. Among them, compounds (3-5) were obtained from the Pandanus genus for the first time and compounds (9-14, 16) were reported from this species for the first time. Their structures were elucidated by HR-ESI-MS, NMR 1D and 2D experiments and comparison with previous reported data. The α-glucosidase inhibitory activity of all compounds was measured. The isolated compounds (1-12, 14) showed better α-glucosidase inhibitory activity (IC50 = 42.2, 36.5, 84.7, 73.2, 40.8, 26.7, 76.5, 33.8, 68.1, 14.4, 22.1, 81.5, 43.8 μM, respectively) than the standard drug acarbose (IC50 = 214.5 μM).
authors.affiliation: a Institute of Chemical Technology , Vietnam Academy of Science and Technology , Ho Chi Minh city , Vietnam.
authors.forename: Tan Phat
authors.initials: TP
authors.lastname: Nguyen
authors.affiliation: a Institute of Chemical Technology , Vietnam Academy of Science and Technology , Ho Chi Minh city , Vietnam.
authors.forename: Tien Dung
authors.initials: TD
authors.lastname: Le
authors.affiliation: a Institute of Chemical Technology , Vietnam Academy of Science and Technology , Ho Chi Minh city , Vietnam.
authors.forename: Phan Nhat
authors.initials: PN
authors.lastname: Minh
authors.affiliation: a Institute of Chemical Technology , Vietnam Academy of Science and Technology , Ho Chi Minh city , Vietnam.
authors.forename: Bui Trong
authors.initials: BT
authors.lastname: Dat
authors.affiliation: b Faculty of Environmental Sciences , Sai Gon University , Ho Chi Minh city , Vietnam.
authors.forename: Nguyen Kim Tuyen
authors.initials: NK
authors.lastname: Pham
authors.affiliation: b Faculty of Environmental Sciences , Sai Gon University , Ho Chi Minh city , Vietnam.|c Faculty of Science, Natural Products Research Unit, Department of Chemistry , Chulalongkorn University , Bangkok , Thailand.
authors.forename: Thi My Lien
authors.initials: TM
authors.lastname: Do
authors.affiliation: d Department of Digestive Surgery , Quang Ngai General Hospital , Quang Ngai city , Vietnam.
authors.forename: Dinh Tuyen
authors.initials: DT
authors.lastname: Nguyen
authors.affiliation: a Institute of Chemical Technology , Vietnam Academy of Science and Technology , Ho Chi Minh city , Vietnam.
authors.forename: Tri Dinh
authors.initials: TD
authors.lastname: Mai
mesh_terms: D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031673:Pandanaceae / Q000737:chemistry*
chemical_list: D003374:Coumarins; D065089:Glycoside Hydrolase Inhibitors
keywords: Pandanus tectorius; pandanusin A; α-glucosidase inhibition