title: Ewing sarcoma: a chronicle of molecular pathogenesis.
abstract: Sarcomas have traditionally been classified according to their chromosomal alterations regardless of whether they accompany simple or complex genetic changes. Ewing sarcoma, a classic small round cell bone tumor, is a well-known mesenchymal malignancy that results from simple sarcoma-specific genetic alterations. The genetic alterations are translocations between genes of the TET/FET family (TLS/FUS, EWSR1, and TAF15) and genes of the E26 transformation-specific (ETS) family. In this review, we intend to summarize a chronicle of molecular findings of Ewing sarcoma including recent advances and explain resultant molecular pathogenesis.
authors.affiliation: Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sang Kyum
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Department of Pathology, Kyung Hee University College of Medicine, Seoul, Korea. Electronic address: ykpark0204@gmail.com.
authors.forename: Yong-Koo
authors.initials: YK
authors.lastname: Park
mesh_terms: D000071443:12E7 Antigen / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics*; D001859:Bone Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D007150:Immunohistochemistry; D025202:Molecular Diagnostic Techniques; D010641:Phenotype; D011237:Predictive Value of Tests; D011379:Prognosis; D012512:Sarcoma, Ewing / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D014158:Transcription, Genetic; D014178:Translocation, Genetic
chemical_list: D000071443:12E7 Antigen; D014408:Biomarkers, Tumor; C061828:CD99 protein, human
keywords: Chromosomal translocation; Ewing sarcoma; Molecular pathogenesis