title: GATA3 Expression Is a Poor Prognostic Factor in Soft Tissue Sarcomas.
abstract: OBJECTIVE
  Recent studies have investigated the significance of GATA3 expression in patients with various malignant tumors. However, no previous studies have evaluated the clinicopathological importance of GATA3 expression in soft tissue sarcomas (STS) patients.
  
  
  METHODS
  We evaluated GATA3 expression in 76 STS cases using immunohistochemical analysis, and statistically compared clinicopathological characteristics between GATA3-positive and GATA3-negative cases.
  
  
  RESULTS
  GATA3-positive expression was significantly associated with a higher mitotic count (P < 0.0001). Disease-free survival (DFS) of GATA3-positive cases was significantly shorter than that of cases without GATA3 expression (P = 0.0104). Overall survival (OS) of GATA3-positive cases was significantly shorter than that of cases without GATA3 expression (P = 0.0006). GATA3-positive expression was significantly associated with shorter DFS in both univariate analysis (hazard ratio [HR], 2.719; P = 0.012) and multivariate analysis (HR, 2.711; P = 0.014). GATA3-positive expression was also significantly associated with worse OS in both univariate analysis (HR, 5.730; P = 0.0007) and multivariate analysis (HR, 5.789; P = 0.0008).
  
  
  CONCLUSIONS
  These results indicate that GATA3 is an independent prognostic factor and suggest that evaluation of GATA3 expression might enable more effective clinical follow-up using prognostic stratification of STS patients.
authors.affiliation: Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.|Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Haraguchi
authors.affiliation: Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Miyoshi
authors.affiliation: Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Hiraoka
authors.affiliation: Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.|Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Yokoyama
authors.affiliation: Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.|Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
authors.forename: Yukinao
authors.initials: Y
authors.lastname: Ishibashi
authors.affiliation: Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.|Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hashiguchi
authors.affiliation: Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.|Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
authors.forename: Koutaro
authors.initials: K
authors.lastname: Matsuda
authors.affiliation: Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hamada
authors.affiliation: Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Okawa
authors.affiliation: Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Shiba
authors.affiliation: Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
mesh_terms: D018572:Disease-Free Survival; D005260:Female; D050990:GATA3 Transcription Factor / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012509:Sarcoma / Q000378:metabolism* / Q000473:pathology
chemical_list: D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human