title: Respiratory function and symptoms in young preterm children in the contemporary era.
abstract: To determine the relationships between respiratory symptoms, lung function, and neonatal events in young preterm children.
  
  
  
  Preterm children (<32 w gestation), classified as bronchopulmonary dysplasia (BPD) or non-BPD, and healthy term controls were studied. Lung function was measured by forced oscillation technique (respiratory resistance [Rrs] and reactance [Xrs]) and spirometry. Respiratory symptom questionnaires were administered.
  
  
  
  One hundred and fifty children (74 BPD, 44 non-BPD, 32 controls) 4-8 years were studied. Lung function (median Z-score [10,90th centile]) was significantly impaired in preterm children compared to controls for FVC (0.00 [-1.18, 1.76], 0.69 [-0.17,1.86]), FEV1(-0.44 [-1.94, 1.11], 0.49 [-0.83, 2.51]), Xrs (-1.26 [-3.31, 0.11], -0.11 [-0.97, 0.73]), and Rrs (0.55 [-0.48, 1.82], 0.28 [-0.99, 0.96]). Only Xrs differed between the BPD and non-BPD (-1.51 [-3.59, -0.41], -0.89 [-2.64, 0.52]). The prevalence of recent respiratory symptoms (range: 32-36%) did not differ between BPD and non-BPD children. Supplemental O2in hospital was positively associated with worsening Xrs and FEV1.
  
  
  
  Preterm children have worse lung function than healthy controls. Only respiratory reactance differentiated between preterm children with and without BPD and was influenced by days of O2in hospital. Pediatr Pulmonol. 2016;51:1347-1355. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Respiratory Medicine, Princess Margaret Hospital for Children, GPO Box D184, Perth 6840, Australia.|University of Western Australia, School of Paediatrics and Child Health, Perth, Australia.|Telethon Kids, Perth, Australia.
authors.forename: Maureen
authors.initials: M
authors.lastname: Verheggen
authors.affiliation: Department of Respiratory Medicine, Princess Margaret Hospital for Children, GPO Box D184, Perth 6840, Australia.|University of Western Australia, School of Paediatrics and Child Health, Perth, Australia.|Telethon Kids, Perth, Australia.|School of Physiotherapy and Exercise Science, Curtin University, Perth, Australia.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Wilson
authors.affiliation: University of Western Australia, School of Anatomy, Physiology and Human Biology, Perth, Australia.|University of Western Australia, Centre for Neonatal Research and Education, Perth, Australia.|King Edward Memorial Hospital, Perth, Australia.
authors.forename: J Jane
authors.initials: JJ
authors.lastname: Pillow
authors.affiliation: Department of Respiratory Medicine, Princess Margaret Hospital for Children, GPO Box D184, Perth 6840, Australia.|University of Western Australia, School of Paediatrics and Child Health, Perth, Australia.|Telethon Kids, Perth, Australia.|Centre for Child Health University of Western Australia, Perth, Australia.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Stick
authors.affiliation: Department of Respiratory Medicine, Princess Margaret Hospital for Children, GPO Box D184, Perth 6840, Australia.|Telethon Kids, Perth, Australia.|School of Physiotherapy and Exercise Science, Curtin University, Perth, Australia.|Centre for Child Health University of Western Australia, Perth, Australia.
authors.forename: Graham L
authors.initials: GL
authors.lastname: Hall
mesh_terms: D000403:Airway Resistance; D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008168:Lung / Q000503:physiopathology*; D008297:Male; D015995:Prevalence; D012129:Respiratory Function Tests; D013147:Spirometry; D011795:Surveys and Questionnaires; D014797:Vital Capacity
keywords: bronchopulmonary dysplasia; exercise; lung function; preterm birth; wheeze