title: A preliminary feasibility study: Narrow-band imaging targeted versus standard white light endoscopy non-targeted biopsies in a surveillance Barrett's population.
abstract: BACKGROUND
  Narrow band imaging (NBI) is used in the detection of intestinal metaplasia (IM) and dysplasia in patients with Barrett's oesophagus (BE).
  
  
  OBJECTIVE
  The study compared the usefulness of NBI with white-light standard endoscopy (WLSE) for the detection of dysplasia and IM in BE and determined the prediction of the histological diagnosis according to the mucosal and vascular patterns obtained by NBI.
  
  
  METHODS
  A total of 84 patients were prospectively enrolled in the study. Every patient underwent a WLSE with random biopsies and after 4-6 weeks, a NBI examination was performed.
  
  
  RESULTS
  NBI detected significant more IM positive biopsies than WLSE (74.5% vs. 35.9%; p<0.0001) and significant more patients with low grade dysplasia (LGD) (7.1% vs. 0%; p=0.03). Taking biopsy samples from the villous pattern determined the diagnosis of IM (80%) and biopsies from the area covered by the irregular pattern lead to the identification of LGD in 45.4% of the cases and indefinite dysplasia (ID) in 18.2% of the cases.
  
  
  CONCLUSIONS
  A thorough analysis of NBI patterns may lead to real-time IM diagnosis in the absence of the histological examination and may require targeted biopsies from the areas with an irregular pattern for diagnosing dysplasia.
authors.affiliation: Department of Gastroenterology, University of Medicine and Pharmacy, Târgu-Mureş, Romania.
authors.forename: Ofelia Daniela
authors.initials: OD
authors.lastname: Pascarenco
authors.affiliation: First Surgical Department, Mureş Clinical County Hospital, University of Medicine and Pharmacy, Târgu-Mureş, Romania. Electronic address: corosmarius1@gmail.com.
authors.forename: Marius Florin
authors.initials: MF
authors.lastname: Coroş
authors.affiliation: First Surgical Department, Mureş Clinical County Hospital, University of Medicine and Pharmacy, Târgu-Mureş, Romania.
authors.forename: Ghenadie
authors.initials: G
authors.lastname: Pascarenco
authors.affiliation: Department of Gastroenterology, University of Medicine and Pharmacy, Târgu-Mureş, Romania.
authors.forename: Alina Mioara
authors.initials: AM
authors.lastname: Boeriu
authors.affiliation: Department of Gastroenterology, University of Medicine and Pharmacy, Târgu-Mureş, Romania.
authors.forename: Silvia Cosmina
authors.initials: SC
authors.lastname: Draşovean
authors.affiliation: Department of Gastroenterology, University of Medicine and Pharmacy, Târgu-Mureş, Romania.
authors.forename: Danusia Maria
authors.initials: DM
authors.lastname: Onişor
authors.affiliation: Department of Gastroenterology, University of Medicine and Pharmacy, Târgu-Mureş, Romania.
authors.forename: Olga
authors.initials: O
authors.lastname: Brusnic
authors.affiliation: Department of Gastroenterology, University of Medicine and Pharmacy, Târgu-Mureş, Romania.
authors.forename: Daniela
authors.initials: D
authors.lastname: Dobru
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus / Q000473:pathology*; D001706:Biopsy / Q000379:methods; D004945:Esophagoscopy / Q000379:methods*; D004947:Esophagus / Q000473:pathology; D005240:Feasibility Studies; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000000981:diagnostic imaging; D006801:Humans; D007422:Intestines / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D062048:Narrow Band Imaging / Q000379:methods*; D011230:Precancerous Conditions / Q000473:pathology; D011446:Prospective Studies; D012383:Romania
keywords: Barrett's oesophagus; Dysplasia; Intestinal metaplasia; NBI