title: Leishmania DNA Replication Timing: A Stochastic Event?
abstract: For eukaryotic genomes, DNA synthesis initiates at multiple discrete regions known as replication origins in a dynamic yet regulated manner to ensure genomic stability. Two recent studies using different approaches reveal few Leishmania origins and that origin firing may proceed in a mainly stochastic manner.
authors.affiliation: Department of Microbiology, University of Massachusetts Amherst, Amherst, MA 01003, USA.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Rocha-Granados
authors.affiliation: Department of Microbiology, University of Massachusetts Amherst, Amherst, MA 01003, USA. Electronic address: klingbeil@microbio.umass.edu.
authors.forename: Michele M
authors.initials: MM
authors.lastname: Klingbeil
mesh_terms: D000818:Animals; D042522:DNA Replication Timing; D016503:Drug Delivery Systems; D042822:Genomic Instability; D006801:Humans; D007891:Leishmania / Q000235:genetics*; D007896:Leishmaniasis / Q000469:parasitology / Q000517:prevention & control; D018741:Replication Origin / Q000235:genetics
keywords: DNA replication; Leishmania; aneuploidy; origin of replication; stochastic timing