title: Preconceptional Iron Intake and Gestational Diabetes Mellitus.
abstract: Our objective was to assess the impact of preconceptional heme and non-heme iron on gestational diabetes mellitius (GDM) in the Boston University Slone Epidemiology Birth Defects Study (BDS). This retrospective cohort analysis included 7229 participants enrolled in the BDS between 1998 and 2008 who gave birth to non-malformed infants and were free of pre-existing diabetes. All data were collected through structured interviews conducted within 6 months of delivery. Calorie-adjusted and multivariable odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression models. Preconceptional dietary heme iron was modestly associated with an elevated risk of GDM among those (multivariable OR comparing the fifth quintile to the first: 1.55; 95% CI 0.98, 2.46). Conversely, preconceptional dietary non-heme iron was associated with a decreased risk of GDM among those in the fifth quintile of intake compared to the first (multivariable OR: 0.48; 95% CI 0.28, 0.81). Women who consumed supplemental iron during preconception also had a decreased risk of GDM (multivariable OR: 0.78; 95% CI 0.60, 1.02). In conclusion, our data support a positive association between preconceptional heme iron intake and GDM and an inverse association between preconceptional non-heme iron intake from foods and preconceptional intake from supplements.
authors.affiliation: Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA. amdarlin@bu.edu.
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Darling
authors.affiliation: Slone Epidemiology Center at Boston University, Boston, MA 02215, USA. allenmit@bu.edu.
authors.forename: Allen A
authors.initials: AA
authors.lastname: Mitchell
authors.affiliation: Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA. werler@bu.edu.|Slone Epidemiology Center at Boston University, Boston, MA 02215, USA. werler@bu.edu.
authors.forename: Martha M
authors.initials: MM
authors.lastname: Werler
mesh_terms: D000328:Adult; D016640:Diabetes, Gestational / Q000453:epidemiology*; D019587:Dietary Supplements; D002149:Energy Intake; D005260:Female; D006801:Humans; D019266:Iron, Dietary / Q000008:administration & dosage*; D016015:Logistic Models; D016017:Odds Ratio; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D019266:Iron, Dietary
keywords: diet; gestational diabetes; iron; pregnancy