title: Management of chronic neuritis with a combination regimen of lower doses prednisolone and methotrexate: a brief report.
abstract: BACKGROUND
  Recommended fixed duration prednisolone regimen was not found effective in the treatment of chronic neuritis. Alternate effective treatment was being sought to reduce the deformity in the field of leprosy.
  
  
  OBJECTIVE
  We wished to see whether a prolonged course of prednisolone and methotrexate could be of any help for them.
  
  
  METHODS
  In 2012-2014, an open pilot clinical study was undertaken where three chronic neuritic patients were treated with lower doses prednisolone and methotrexate for 12 months and a follow up period was delivered for 12 months. The study was undertaken in one of the outdoor clinics of the university.
  
  
  RESULTS
  Complete and permanent remission of neuritis was achieved with appreciable functional recovery. Few mild self-limiting side-effects from prednisolone were observed and there was no side-effects from methotrexate.
  
  
  CONCLUSIONS
  Prolonged course of prednisolone and methotrexate was found safe and effective in treating chronic neuritis.
authors.forename: Delwar
authors.initials: D
authors.lastname: Hossain
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007918:Leprosy / Q000150:complications*; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D009443:Neuritis / Q000188:drug therapy* / Q000209:etiology; D010865:Pilot Projects; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D011239:Prednisolone; D008727:Methotrexate