title: Accelerator-based production of the (99m)Tc-(186)Re diagnostic-therapeutic pair using metal disulfide targets (MoS2, WS2, OsS2).
abstract: Novel, natural abundance metal disulfide targets were irradiated for 1h with a 10µA proton beam in a small, medical cyclotron. Osmium disulfide was synthesized by simple distillation and precipitation methods while MoS2 and WS2 were commercially available. The targets dissolved under mild conditions and were analyzed by γ-spectroscopy. Production rates and potential applications are discussed, including target recovery and recycling schemes for OsS2 and WS2.
authors.affiliation: Department of Chemistry, University of Missouri, Columbia, MO 65211, United States.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Gott
authors.affiliation: Department of Chemistry, University of Missouri, Columbia, MO 65211, United States.
authors.forename: Connor R
authors.initials: CR
authors.lastname: Hayes
authors.affiliation: Department of Chemistry, University of Missouri, Columbia, MO 65211, United States.
authors.forename: Donald E
authors.initials: DE
authors.lastname: Wycoff
authors.affiliation: Department of Radiation Oncology, University of Washington, Seattle, WA 98105, United States.
authors.forename: Ethan R
authors.initials: ER
authors.lastname: Balkin
authors.affiliation: Department of Chemistry, University of Washington, Seattle, WA 98105, United States.
authors.forename: Bennett E
authors.initials: BE
authors.lastname: Smith
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, WA 98105, United States.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Pauzauskie
authors.affiliation: Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545, United States.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Fassbender
authors.affiliation: University of Missouri Research Reactor Center, Columbia, MO 65211, United States.
authors.forename: Cathy S
authors.initials: CS
authors.lastname: Cutler
authors.affiliation: University of Missouri Research Reactor Center, Columbia, MO 65211, United States.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Ketring
authors.affiliation: Department of Radiation Oncology, University of Washington, Seattle, WA 98105, United States.
authors.forename: D Scott
authors.initials: DS
authors.lastname: Wilbur
authors.affiliation: Department of Chemistry, University of Missouri, Columbia, MO 65211, United States. Electronic address: jurissons@missouri.edu.
authors.forename: Silvia S
authors.initials: SS
authors.lastname: Jurisson
mesh_terms: D017357:Cyclotrons; D004220:Disulfides / Q000528:radiation effects; D006801:Humans; D008982:Molybdenum / Q000528:radiation effects; D017892:Osmium Compounds / Q000528:radiation effects; D011522:Protons; D011868:Radioisotopes / Q000302:isolation & purification*; D019275:Radiopharmaceuticals / Q000302:isolation & purification; D012211:Rhenium / Q000302:isolation & purification*; D013051:Spectrometry, Gamma; D013667:Technetium / Q000302:isolation & purification*; D017973:Tungsten Compounds / Q000528:radiation effects
chemical_list: D004220:Disulfides; D017892:Osmium Compounds; D011522:Protons; D011868:Radioisotopes; D019275:Radiopharmaceuticals; C000615079:Rhenium-186; D017973:Tungsten Compounds; D012211:Rhenium; D013667:Technetium; D008982:Molybdenum; C082964:molybdenum disulfide
keywords: High specific activity (186)Re; High specific activity (99m)Tc; Metal disulfide targets; MoS(2); OsS(2); WS(2)