title: Aflatoxin B1 induced upregulation of protein arginine methyltransferase 5 in human cell lines.
abstract: The exposure of naturally occurring mycotoxins affects human health and play a vital role in cancer initiation and progression. Aflatoxin B1 is a difuranocoumarin mycotoxin, classified as a group I carcinogen. The present study was conducted to assess the effect of aflatoxin B1 on epigenetic regulatory proteins. The protein arginine methyltransferase 5 expression was induced upon aflatoxin B1 treatment in a dose and time dependent manner. Further global arginine methylation was also increased in the same manner. This is the first report showing the induction of epigenetic regulatory protein, protein arginine methyltransferase 5 upon aflatoxin B1 treatment. Further study is required to establish the detailed pathway of PRMT5 induction.
authors.affiliation: Department of Biochemistry and Molecular Biology, Central University of Kerala, Kasargod, Kerala, 671314, India.
authors.forename: Md Sajid
authors.initials: MS
authors.lastname: Ghufran
authors.affiliation: Department of Biochemistry and Molecular Biology, Central University of Kerala, Kasargod, Kerala, 671314, India.
authors.forename: Krishna
authors.initials: K
authors.lastname: Ghosh
authors.affiliation: Department of Biochemistry and Molecular Biology, Central University of Kerala, Kasargod, Kerala, 671314, India. Electronic address: grksantosh@gmail.com.
authors.forename: Santosh R
authors.initials: SR
authors.lastname: Kanade
mesh_terms: D016604:Aflatoxin B1 / Q000633:toxicity*; D002460:Cell Line; D006801:Humans; D011484:Protein-Arginine N-Methyltransferases / Q000235:genetics*; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D016604:Aflatoxin B1; C400529:PRMT5 protein, human; D011484:Protein-Arginine N-Methyltransferases
keywords: Aflatoxin; Arginine methylation; Aspergillus flavus; PRMT5; SDMA