title: Depression Symptoms in Chronic Left Hemisphere Stroke Are Related to Dorsolateral Prefrontal Cortex Damage.
abstract: Damage to the brain's mood regulation systems may contribute to poststroke depression. This study examines relationships between depression symptoms and psychosocial factors and then uses multivariate lesion-symptom mapping to localize depression symptoms in people with chronic left hemisphere stroke. Depression symptoms relate inversely to education and directly to physical disability. Damage in the left dorsolateral prefrontal cortex is associated with greater depression symptoms. These results demonstrate a neurological contribution to depression symptoms in chronic left hemisphere stroke and provide evidence of convergent biological mechanisms for poststroke depression symptoms and major depression with regard to left dorsolateral prefrontal cortex dysfunction.
authors.affiliation: From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
authors.forename: Kristopher
authors.initials: K
authors.lastname: Grajny
authors.affiliation: From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
authors.forename: Harshini
authors.initials: H
authors.lastname: Pyata
authors.affiliation: From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
authors.forename: Katherine
authors.initials: K
authors.lastname: Spiegel
authors.affiliation: From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Lacey
authors.affiliation: From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
authors.forename: Shihui
authors.initials: S
authors.lastname: Xing
authors.affiliation: From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
authors.forename: Carl
authors.initials: C
authors.lastname: Brophy
authors.affiliation: From the Neurology Dept., Georgetown University Medical Center, Washington, DC (KJ, HP, EHL, SX, PET); the University of Connecticut, Storrs, Conn. (KS); the Research Division, MedStar National Rehabilitation Hospital, Washington, DC (EHL, PET); the Dept. of Neurology, First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China (SX); and the Georgetown University School of Medicine, Washington, DC (CB).
authors.forename: Peter E
authors.initials: PE
authors.lastname: Turkeltaub