title: Posttranslational control of the scaffold for Fe-S cluster biogenesis as a compensatory regulatory mechanism.
abstract: Though toxic in excess, iron is vital for life. Thus, its use in all cells is tightly regulated. Analysis of Saccharomyces cerevisiae, which has been used extensively as a model system, has revealed layers of regulation of cellular iron trafficking and utilization. This regulation is based on the availability of both elemental iron and functionality of the Fe-S cluster biogenesis system. Here, we discuss a possible "first responder" regulatory mechanism centered on the stability of the scaffold protein on which Fe-S clusters are built.
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI, 53706, USA.
authors.forename: Szymon J
authors.initials: SJ
authors.lastname: Ciesielski
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI, 53706, USA. ecraig@wisc.edu.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Craig
mesh_terms: D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D059748:Proteolysis; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism; D013455:Sulfur / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D024101:Mitochondrial Proteins; D029701:Saccharomyces cerevisiae Proteins; D013455:Sulfur; D007501:Iron
keywords: Fe–S cluster biogenesis; Lon proteases; Mitochondria; Mitochondrial dysfunction; Posttranslational regulation