title: Endovascular therapy for advanced post-thrombotic syndrome: Proceedings from a multidisciplinary consensus panel.
abstract: Patients with advanced post-thrombotic syndrome (PTS) and chronic iliac vein obstruction suffer major physical limitations and impairment of health-related quality of life. Currently there is a lack of evidence-based treatment options for these patients. Early studies suggest that imaging-guided, catheter-based endovascular therapy can eliminate iliac vein obstruction and saphenous venous valvular reflux, resulting in reduced PTS severity; however, these observations have not been rigorously validated. A multidisciplinary expert panel meeting was convened to plan a multicenter randomized controlled clinical trial to evaluate endovascular therapy for the treatment of advanced PTS. This article summarizes the findings of the panel, and is expected to assist in developing a National Institutes of Health-sponsored clinical trial and other studies to improve the care of patients with advanced PTS.
authors.affiliation: Washington University in St Louis, St Louis, MO, USA vedanthams@mir.wustl.edu.
authors.forename: Suresh
authors.initials: S
authors.lastname: Vedantham
authors.affiliation: SMBD Jewish General Hospital, Montreal, QC, Canada.
authors.forename: Susan R
authors.initials: SR
authors.lastname: Kahn
authors.affiliation: Brigham and Womens Hospital, Boston, MA, USA.
authors.forename: Samuel Z
authors.initials: SZ
authors.lastname: Goldhaber
authors.affiliation: The Toledo Hospital, Toledo, OH, USA.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Comerota
authors.affiliation: McMaster University, Hamilton, ON, Canada.
authors.forename: Sameer
authors.initials: S
authors.lastname: Parpia
authors.affiliation: Research Triangle International, Research Triangle Park, NC, USA.
authors.forename: Sreelatha
authors.initials: S
authors.lastname: Meleth
authors.affiliation: Research Triangle International, Research Triangle Park, NC, USA.
authors.forename: Diane
authors.initials: D
authors.lastname: Earp
authors.affiliation: Research Triangle International, Research Triangle Park, NC, USA.
authors.forename: Rick
authors.initials: R
authors.lastname: Williams
authors.affiliation: New York University School of Medicine, New York, NY, USA.
authors.forename: Akhilesh K
authors.initials: AK
authors.lastname: Sista
authors.affiliation: University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: William
authors.initials: W
authors.lastname: Marston
authors.affiliation: OK Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Suman
authors.initials: S
authors.lastname: Rathbun
authors.affiliation: Mid America Heart Institute, Kansas City, MO, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Magnuson
authors.affiliation: St Joseph's Hospital, Orange, CA, USA.
authors.forename: Mahmood K
authors.initials: MK
authors.lastname: Razavi
authors.affiliation: Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Jaff
authors.affiliation: McMaster University, Hamilton, ON, Canada.
authors.forename: Clive
authors.initials: C
authors.lastname: Kearon
mesh_terms: D032921:Consensus; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation; D006801:Humans; D015337:Multicenter Studies as Topic / Q000379:methods*; D054070:Postthrombotic Syndrome / Q000175:diagnosis / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012107:Research Design
keywords: deep vein thrombosis; endovascular therapy; post-thrombotic syndrome; quality of life; stent