title: Rab32/38 and the xenophagic restriction of intracellular bacteria replication.
abstract: Rab GTPases' subversion by intracellular pathogens during infection has been extensively documented. Recent findings have implicated a key intracellular bacterial restriction/containment function for Rab32/38 in Salmonella species in macrophages and Listeria monocytogenes in dendritic cells. Rab32/38 aids the phagolysosome maturation, and mediates a parallel xenophagy mechanism by engaging prohibitins.
authors.affiliation: Department of Biochemistry and NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore. Electronic address: bchtbl@nus.edu.sg.
authors.forename: Bor Luen
authors.initials: BL
authors.lastname: Tang
mesh_terms: D003713:Dendritic Cells / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D008089:Listeria monocytogenes / Q000276:immunology*; D008247:Lysosomes / Q000382:microbiology*; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D010588:Phagosomes / Q000382:microbiology; D012475:Salmonella / Q000276:immunology*; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
chemical_list: C412058:RAB38 protein, human; C466094:Rab32 protein, human; D020691:rab GTP-Binding Proteins
keywords: Bacteria-containing vacuole; Listeria; Prohibitin; Rab; Salmonella; Xenophagy