title: The relationship between blood pressure variability and Pooled Cohort Risk Assessment Equations 10-year cardiovascular risk score.
abstract: BACKGROUND
  Recent attention has focused on the clinical significance of blood pressure variability (BPV) in explaining the adverse cardiovascular consequences of hypertension. We therefore analyze the impact of 24 h BPV on the development of future cardiovascular disease determined by The Pooled Cohort Risk Assessment Equations 10-year risk calculator.
  
  
  METHODS
  We analyzed 250 adult patients, ages 40-80 years old. The ambulatory blood pressure monitoring was recorded automatically. We defined the mean blood pressure values, SD, and coefficient of variation (CV) of blood pressure on the basis of the recorded 24 h ambulatory blood pressure monitoring values as an indicator for BPV.Patients were divided into two groups according to their Pooled Cohort Risk Assessment Equations 10-year risk profile (<7.5 and ≥7.5%).
  
  
  RESULTS
  Besides the mean systolic blood pressure (SBP), parameters showing the BPV such as SD and CV of mean blood pressures were also significantly higher in patients with an elevated 10-year risk score compared with others. Only CV of SBP and pulse pressure showed a clear association with the 10-year risk in multivariate logistic regression analysis. The results suggested that each 1% increase in CV of SBP could lead to a 1.258-fold increase in The Pooled Cohort Risk Assessment Equations 10-year risk score.
  
  
  CONCLUSIONS
  In the present study, we found that independent of baseline SBP, increased CV of SBP within 24 h was associated with increased cardiovascular risk, as assessed by The Pooled Cohort Risk Assessment Equations 10-year risk calculator.
authors.affiliation: aGulhane Military Medical Academy, Department of Cardiology bEtimesgut Military Hospital, Service of Cardiology cBeytepe Military Hospital, Service of Cardiology, Ankara dMemorial Sisli Hospital, Service of Cardiology, Istanbul, Turkey eGirne Military Hospital, Service of Cardiology, Kyrenia, Cyprus.
authors.forename: Murat
authors.initials: M
authors.lastname: Celik
authors.forename: Uygar Cagdas
authors.initials: UC
authors.lastname: Yuksel
authors.forename: Erkan
authors.initials: E
authors.lastname: Yildirim
authors.forename: Erol
authors.initials: E
authors.lastname: Gursoy
authors.forename: Mustafa
authors.initials: M
authors.lastname: Koklu
authors.forename: Salim
authors.initials: S
authors.lastname: Yasar
authors.forename: Suat
authors.initials: S
authors.lastname: Gormel
authors.forename: Mutlu
authors.initials: M
authors.lastname: Gungor
authors.forename: Baris
authors.initials: B
authors.lastname: Bugan
authors.forename: Cem
authors.initials: C
authors.lastname: Barcin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors