title: Periodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cells.
abstract: Despite the worldwide interest generated by periodic mesoporous organosilica (PMO) bulk materials, the design of PMO nanomaterials with controlled morphology remains largely unexplored and their properties unknown. In this work, we describe the first study of PMO nanoparticles (NPs) based on meta-phenylene bridges, and we conducted a comparative structure-property relationship investigation with para-phenylene-bridged PMO NPs. Our findings indicate that the change of the isomer drastically affects the structure, morphology, size, porosity and thermal stability of PMO materials. We observed a much higher porosity and thermal stability of the para-based PMO which was likely due to a higher molecular periodicity. Additionally, the para isomer could generate multipodal NPs at very low stirring speed and upon this discovery we designed a phenylene-ethylene bridged PMO with a controlled Janus morphology. Unprecedentedly high payloads could be obtained from 40 to 110 wt % regardless of the organic bridge of PMOs. Finally, we demonstrate for the first time the co-delivery of two cargos by PMO NPs. Importantly, the cargo stability in PMOs did not require the capping of the pores, unlike pure silica, and the delivery could be autonomously triggered in cancer cells by acidic pH with nearly 70 % cell killing.
authors.affiliation: Smart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.|Department of Chemistry and Biochemistry, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA.
authors.forename: Jonas G
authors.initials: JG
authors.lastname: Croissant
authors.affiliation: Smart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
authors.forename: Yevhen
authors.initials: Y
authors.lastname: Fatieiev
authors.affiliation: Smart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
authors.forename: Haneen
authors.initials: H
authors.lastname: Omar
authors.affiliation: Imaging and Characterization Laboratory, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
authors.forename: Dalaver H
authors.initials: DH
authors.lastname: Anjum
authors.affiliation: Imaging and Characterization Laboratory, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
authors.forename: Andrey
authors.initials: A
authors.lastname: Gurinov
authors.affiliation: Department of Microbiology, Immunology and Molecular Genetics, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Microbiology, Immunology and Molecular Genetics, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA.
authors.forename: Fuyuhiko
authors.initials: F
authors.lastname: Tamanoi
authors.affiliation: Department of Chemistry and Biochemistry, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA. zink@chem.ucla.edu.
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Zink
authors.affiliation: Smart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia. Niveen.khashab@kaust.edu.sa.
authors.forename: Niveen M
authors.identifier: 0000-0003-2728-0666
authors.initials: NM
authors.lastname: Khashab
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D016503:Drug Delivery Systems / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D049329:Nanostructures / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D017646:Organosilicon Compounds
keywords: Janus nanoparticles; bridged silsesquioxanes; drug delivery; mesoporous materials; nanoparticles