title: Serum Malondialdehyde Concentration and Glutathione Peroxidase Activity in a Longitudinal Study of Gestational Diabetes.
abstract: The main goal of this study was to evaluate the presence of oxidative damage and to quantify its level in gestational diabetes.
  
  
  
  Thirty-six healthy women and thirty-six women with gestational diabetes were studied in the three trimesters of pregnancy regarding their levels of oxidative stress markers. These women were diagnosed with diabetes in the second trimester of pregnancy. Blood glucose levels after 100g glucose tolerance test were higher than 190, 165 or 145 mg/dl, 1, 2 or 3 hours after glucose intake.
  
  
  
  The group of women with gestational diabetes had higher serum malondialdehyde levels, with significant differences between groups in the first and second trimester. The mean values of serum glutathione peroxidase activity in the diabetic women were significantly lower in the first trimester. In the group of women with gestational diabetes there was a negative linear correlation between serum malondialdehyde concentration and glutathione peroxidase activity in the second and third trimester.
  
  
  
  In this observational and longitudinal study in pregnant women, the alterations attributable to oxidative stress were present before the biochemical detection of the HbA1c increase. Usual recommendations once GD is detected (adequate metabolic control, as well as any other normally proposed to these patients) lowered the concentration of malondialdehyde at the end of pregnancy to the same levels of the healthy controls. Serum glutathione peroxidase activity in women with gestational diabetes increased during the gestational period.
authors.affiliation: Unidad de Diabetes, Servicio de Medicina Interna, Hospital de La Plana, Vila-real, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Arribas
authors.affiliation: Dept. Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Valencia, Spain.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Almansa
authors.affiliation: Dept. Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Valencia, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Miranda
authors.affiliation: Dept. Medicina, Universidad Jaume I, Castelló, Valencia, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Muriach
authors.affiliation: Facultad de Medicina, Universidad Católica de Valencia "San Vicente Martir", Valencia, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Romero
authors.affiliation: Dept. Ciencias Biomédicas, Universidad CEU Cardenal Herrera, Valencia, Spain.
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Villar
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress; D011247:Pregnancy
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde; D005979:Glutathione Peroxidase