title: [LAMA/LABA fixed dose combination for treatment of COPD].
abstract: Several new fixed-dose combination bronchodilators have been launched in the world, and 3 different types are now available in Japan. Assessing their efficacy relative to each other has not been performed yet. In the present manuscript, characteristics of glycopyrronium/indacaterol, umeclidinium/vilanterol and tiotropium/olodaterol were reviewed. In particular, changes in trough and peak forced expiratory volume in 1 second (FEV1), St George's Respiratory Questionnaire (SGRQ) total scores, and transitional dyspnea index (TDI) focal scores were reviewed in these bronchodilators.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kuwahira
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists / Q000008:administration & dosage*; D048588:Benzoxazines / Q000008:administration & dosage*; D001592:Benzyl Alcohols / Q000008:administration & dosage*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D002722:Chlorobenzenes / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D005541:Forced Expiratory Volume; D006024:Glycopyrrolate / Q000008:administration & dosage*; D006801:Humans; D007189:Indans / Q000008:administration & dosage*; D018727:Muscarinic Antagonists / Q000008:administration & dosage*; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D015363:Quinolones / Q000008:administration & dosage*; D011812:Quinuclidines / Q000008:administration & dosage*; D012129:Respiratory Function Tests; D000069447:Tiotropium Bromide / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D048588:Benzoxazines; D001592:Benzyl Alcohols; D001993:Bronchodilator Agents; D002722:Chlorobenzenes; D003692:Delayed-Action Preparations; D004338:Drug Combinations; C573971:GSK573719; D007189:Indans; D018727:Muscarinic Antagonists; D015363:Quinolones; D011812:Quinuclidines; C550468:vilanterol; C510790:indacaterol; D006024:Glycopyrrolate; C549647:olodaterol; D000069447:Tiotropium Bromide