title: Optical Windows for Imaging the Metastatic Tumour Microenvironment in vivo.
abstract: Intravital imaging enables to study dynamic tumour-stroma interactions within primary and metastatic sites, including the lung. The combination of optical windows with specific molecular probes targeting the tumour microenvironment will provide new insights into prometastatic stromal interactions and lead to novel therapeutic strategies for metastatic diseases.
authors.affiliation: MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, EH16 4TJ, UK.
authors.forename: Takanori
authors.initials: T
authors.lastname: Kitamura
authors.affiliation: MRC Centre for Reproductive Health, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, EH16 4TJ, UK; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York 10461, USA.
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Pollard
authors.affiliation: MRC Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, EH16 4TJ, UK. Electronic address: mvendrel@staffmail.ed.ac.uk.
authors.forename: Marc
authors.initials: M
authors.lastname: Vendrell
mesh_terms: D000818:Animals; D006801:Humans; D000069416:Intravital Microscopy / Q000379:methods*; D008856:Microscopy, Fluorescence / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D009362:Neoplasm Metastasis / Q000473:pathology* / Q000503:physiopathology*; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D059016:Tumor Microenvironment
keywords: cancer; fluorescence; immune cells; metastasis; probes; stromal cells