title: Elemental analysis of tissue pellets for the differentiation of epidermal lesion and normal skin by laser-induced breakdown spectroscopy.
abstract: By laser induced breakdown spectroscopy (LIBS) analysis of epidermal lesion and dermis tissue pellets of hairless mouse, it is shown that Ca intensity in the epidermal lesion is higher than that in dermis, whereas Na and K intensities have an opposite tendency. It is demonstrated that epidermal lesion and normal dermis can be differentiated with high selectivity either by univariate or multivariate analysis of LIBS spectra with an intensity ratio difference by factor of 8 or classification accuracy over 0.995, respectively.
authors.affiliation: Department of Medical System Engineering, Gwangju Institute of Science and Technology, 1 Oryong-dong Buk-gu, Gwangju 500-712, South Korea; Co-first authors with equal contribution.
authors.forename: Youngmin
authors.initials: Y
authors.lastname: Moon
authors.affiliation: Department of Medical System Engineering, Gwangju Institute of Science and Technology, 1 Oryong-dong Buk-gu, Gwangju 500-712, South Korea; Co-first authors with equal contribution.
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Han
authors.affiliation: School of Mechatronics, Gwangju Institute of Science and Technology, 1 Oryong-dong Buk-gu, Gwangju 500-712, South Korea.
authors.forename: Sungho
authors.initials: S
authors.lastname: Shin
authors.affiliation: Department of Medical System Engineering, Gwangju Institute of Science and Technology, 1 Oryong-dong Buk-gu, Gwangju 500-712, South Korea; School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-dong Buk-gu, Gwangju 500-712, South Korea.
authors.forename: Yong-Chul
authors.initials: YC
authors.lastname: Kim
authors.affiliation: School of Mechatronics, Gwangju Institute of Science and Technology, 1 Oryong-dong Buk-gu, Gwangju 500-712, South Korea.
authors.forename: Sungho
authors.initials: S
authors.lastname: Jeong
keywords: (120.3890) Medical optics instrumentation; (170.1580) Chemometrics; (170.1870) Dermatology; (300.6365) Spectroscopy, laser induced breakdown