title: Oncogenic and incidental HPV types associated with histologically confirmed cervical intraepithelial neoplasia in HIV-positive and HIV-negative South African women.
abstract: BACKGROUND
  In Africa, data on the relationship between oncogenic human papillomavirus (HPV) types, immune status and cervical preinvasive lesions are lacking.
  
  
  METHODS
  We investigated low-risk (lrHPV) and high-risk (hrHPV) HPV types in a cohort of women with cervical intraepithelial neoplasia (CIN) II/III confirmed on histological examination, in an urban setting with a high prevalence of HIV infection.
  
  
  RESULTS
  Of 270 women with confirmed CIN II/III, 45 were HIV-negative and 225 HIV-positive. HIV-infected women had significantly more HPV type infections, including all HPV (p&lt;0.001) and hrHPV (p=0.014) types. The prevalences of one or more hrHPV type/s were 93.3% and 92.9% in HIV-negative and positive patients, respectively. The most prevalent hrHPV type among HIV-negative women was HPV 16, followed by HPV 52, 31, 35 and 58. Among HIV-positive women, HPV 16 was followed by HPV 58, 35, 51 and 52. Not yet qualifying qualify for highly active antiretroviral therapy (HAART) (CD4 count &gt;350 cells/μL) or having received HAART for ≥12 months were negatively associated with HPV 18, 33, 45, 51, 52, 59 and 82.
  
  
  CONCLUSIONS
  In South Africa, burdened by the HIV pandemic, high numbers of high- and low-risk HPV type infections are present in women with cervical preneoplasia. HPV type distribution differs among varying levels of HIV-induced immune depletion.
authors.affiliation: Gynaecological Oncology Unit, Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, University of Pretoria, South Africa. mc@vanaardt.net.
authors.forename: Matthys Cornelis
authors.initials: MC
authors.lastname: Van Aardt
authors.forename: Greta
authors.initials: G
authors.lastname: Dreyer
authors.forename: Leon Cornelius
authors.initials: LC
authors.lastname: Snyman
authors.forename: Karin Louise
authors.initials: KL
authors.lastname: Richter
authors.forename: Piet
authors.initials: P
authors.lastname: Becker
authors.forename: Sebolelo Mpho
authors.initials: SM
authors.lastname: Mojaki