title: Fulminant spinal cord compression caused by postradiation inflammatory pseudotumor with rapid response to steroids: case report.
abstract: Radiation therapy continues to play an extremely valuable role in the treatment of malignancy. The effects of radiation therapy on normal tissue can present in a delayed fashion, resulting in localized damage with pseudomalignant transformation, producing a compressive effect on the spinal cord or exiting nerve roots. Infiltration of inflammatory cells and the subsequent fibrotic response can result in the development of an inflammatory pseudotumor (benign tumor-like lesion) with subsequent mass effect. Herein, the authors present a rare case of inflammatory pseudotumor with fulminant cervicothoracic cord compression, developing 7 years after radiation therapy for breast cancer. The lesion recurred following resection but subsequently displayed complete and rapid resolution following steroid therapy. To the best of the authors' knowledge, no previous studies have reported such an incident.
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Terence
authors.initials: T
authors.lastname: Verla
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Jonathan G
authors.initials: JG
authors.lastname: Thomas
authors.affiliation: Pathology, Baylor College of Medicine.
authors.forename: Vilmos
authors.initials: V
authors.lastname: Thomazy
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center; and.
authors.forename: Gregory N
authors.initials: GN
authors.lastname: Fuller
authors.affiliation: Nerve and Muscle Center of Texas, Houston, Texas.
authors.forename: Aziz
authors.initials: A
authors.lastname: Shaibani
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Omeis
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000532:radiotherapy / Q000601:surgery; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005260:Female; D006104:Granuloma, Plasma Cell / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008875:Middle Aged; D011832:Radiation Injuries / Q000000981:diagnostic imaging / Q000188:drug therapy*; D013117:Spinal Cord Compression / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D013256:Steroids / Q000627:therapeutic use*; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging
chemical_list: D007155:Immunologic Factors; D013256:Steroids
keywords: IPT = inflammatory pseudotumor; fulminant cord compression; inflammatory pseudotumor; oncology; radiation effects; steroids