title: Elevated expression of CD93 promotes angiogenesis and tumor growth in nasopharyngeal carcinoma.
abstract: CD93, also known as the complement component C1q receptor (C1qRp), has been reported to promote the progression of some cancer types. However, the expression and physiological significance of CD93 in nasopharyngeal carcinoma (NPC) remain largely elusive. In this study, we first examined the expression of CD93 in NPC and experimentally manipulated its expression. We observed that vascular CD93 expression is elevated in NPC and is correlated with T classification, N classification, distant metastasis, clinical stage and poor prognosis (all P < 0.05). In addition, overexpression of CD93 promoted angiogenesis in vitro. What's more, we found that CD93 was highly expressed in NPC tissues and cells, and the regulation of CD93 on cell proliferation was determined by cell counting kit (CCK)-8 assay and cell cycle analyses. Our findings provide unique insight into the pathogenesis of NPC and underscore the need to explore novel therapeutic targets such as CD93 to improve NPC treatment.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Bao
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Cancer Hospital of Nantong University, Nantong, 226361, Jiangsu, China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Tang
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Qicheng
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Bo
authors.initials: B
authors.lastname: You
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shan
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Si
authors.initials: S
authors.lastname: Shi
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China. Electronic address: hsq@ntu.edu.cn.
authors.forename: Songqun
authors.initials: S
authors.lastname: Hu
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China. Electronic address: youyiwen_nantong@163.com.
authors.forename: Yiwen
authors.initials: Y
authors.lastname: You
mesh_terms: D002277:Carcinoma; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D005260:Female; D015870:Gene Expression; D055785:Gene Knockdown Techniques; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000098:blood supply* / Q000276:immunology* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000276:immunology; D034741:RNA, Small Interfering / Q000235:genetics; D011951:Receptors, Complement / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D008562:Membrane Glycoproteins; D034741:RNA, Small Interfering; D011951:Receptors, Complement; C032402:complement 1q receptor
keywords: Angiogenesis; CD93; Nasopharyngeal carcinoma (NPC); Proliferation