title: Discriminative Stimulus Properties of Opioid Ligands: Progress and Future Directions.
abstract: Opioid receptors (MOP-r, KOP-r, DOP-r, as well as NOP-r) and their endogenous neuropeptide agonist systems are involved in diverse neurobiological and behavioral functions, in health and disease. These functions include pain and analgesia, addictions, and psychiatric diseases (e.g., depression-, anxiety-like, and stress-related disorders). Drug discrimination assays have been used to characterize the behavioral pharmacology of ligands with affinity at MOP-r, KOP-r, or DOP-r (and to a lesser extent NOP-r). Therefore, drug discrimination studies with opioid ligands have an important continuing role in translational investigations of diseases that are affected by these neurobiological targets and their pharmacotherapy.
authors.affiliation: Laboratory on the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY, 10065, USA. butelme@rockefeller.edu.
authors.forename: Eduardo R
authors.initials: ER
authors.lastname: Butelman
authors.affiliation: Laboratory on the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY, 10065, USA.
authors.forename: Mary Jeanne
authors.initials: MJ
authors.lastname: Kreek
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004192:Discrimination, Psychological / Q000187:drug effects*; D006801:Humans; D008024:Ligands; D009292:Narcotic Antagonists; D011957:Receptors, Opioid / Q000187:drug effects*
chemical_list: D000701:Analgesics, Opioid; D008024:Ligands; D009292:Narcotic Antagonists; D011957:Receptors, Opioid
keywords: Addiction; Analgesia; Drug discrimination; Opioid; Prescription opioids