title: HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis.
abstract: BACKGROUND
  The HLA-DRB*1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology.
  
  
  OBJECTIVE
  To assess HLA-DRB(*)1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology.
  
  
  METHODS
  Whole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB(*)1501 haplotype was determined by genotyping (rs3135388).
  
  
  RESULTS
  No significant differences were observed in MRI measures between the HLA-DRB(*)1501 subgroups.
  
  
  CONCLUSIONS
  The HLA-DRB(*)1501 haplotype is not strongly associated with MRI-visible grey matter pathology.
authors.affiliation: Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; Department of Neurology, University Hospital Basel, Basel, Switzerland. Electronic address: o.yaldizli@ucl.ac.uk.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Yaldizli
authors.affiliation: Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK.
authors.forename: Varun
authors.initials: V
authors.lastname: Sethi
authors.affiliation: Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Pardini
authors.affiliation: Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; MS Centre of Catalonia (Cemcat), Neurology-Neuroimmunology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Tur
authors.affiliation: Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Division of Life Science, Hong Kong University of Science and Technology, Hong Kong SAR, China.
authors.forename: Kin Y
authors.initials: KY
authors.lastname: Mok
authors.affiliation: Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; School of Psychology and Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK; School of Psychological Sciences, University of Manchester, Manchester, UK.
authors.forename: Nils
authors.initials: N
authors.lastname: Muhlert
authors.affiliation: Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK.
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Samson
authors.affiliation: Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK.
authors.forename: Claudia A M
authors.initials: CA
authors.lastname: Wheeler-Kingshott
authors.affiliation: Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre, UK; Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK; Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, UK.
authors.forename: Tarek A
authors.initials: TA
authors.lastname: Yousry
authors.affiliation: Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
authors.forename: Henry
authors.initials: H
authors.lastname: Houlden
authors.affiliation: Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.affiliation: Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre, UK.
authors.forename: David H
authors.initials: DH
authors.lastname: Miller
authors.affiliation: Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre, UK.
authors.forename: Declan T
authors.initials: DT
authors.lastname: Chard
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D004185:Disability Evaluation; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D066128:Gray Matter / Q000000981:diagnostic imaging*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging* / Q000235:genetics*; D009929:Organ Size; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D059811:HLA-DRB1 Chains; C489631:HLA-DRB1*15:01 antigen
keywords: Cortical lesion; Grey matter; HLA-DRB*1501; Magnetization transfer ratio; Multiple sclerosis