title: Short Communication: Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy.
abstract: Coinfections with Hepatitis C virus and human immunodeficiency virus accelerate the progression of both conditions and hamper effective treatment. Here we describe expression of CXCR3 on liver-infiltrating cells and peripheral T cells from coinfected patients commencing antiretroviral therapy (ART) in Indonesia. CXCR3 was expressed by small number of intrahepatic inflammatory cells, mostly in the portal areas. The number of cells did not change on ART and was markedly lower than the number of CD4+and CD8+cells in the liver. Data suggest that CXCR3 may contribute to liver infiltration but demonstrate a dynamic situation, changing as the immune system recovers on ART.
authors.affiliation: 1 Department of Anatomical Pathology, University of Indonesia , Cipto Mangunkusumo Hospital, Jakarta, Indonesia .
authors.forename: Marini
authors.initials: M
authors.lastname: Stephanie
authors.affiliation: 1 Department of Anatomical Pathology, University of Indonesia , Cipto Mangunkusumo Hospital, Jakarta, Indonesia .
authors.forename: Yosephine G
authors.initials: YG
authors.lastname: Susufi
authors.affiliation: 1 Department of Anatomical Pathology, University of Indonesia , Cipto Mangunkusumo Hospital, Jakarta, Indonesia .
authors.forename: Ening
authors.initials: E
authors.lastname: Krisnuhoni
authors.affiliation: 2 Department of Internal Medicine, Medical Faculty, University of Indonesia , Cipto Mangunkusumo Hospital, Jakarta, Indonesia .
authors.forename: Rino A
authors.initials: RA
authors.lastname: Gani
authors.affiliation: 2 Department of Internal Medicine, Medical Faculty, University of Indonesia , Cipto Mangunkusumo Hospital, Jakarta, Indonesia .
authors.forename: Evy
authors.initials: E
authors.lastname: Yunihastuti
authors.affiliation: 3 Department of Microbiology, Royal Perth Hospital , Perth, Western Australia, Australia .|5 School of Biomedical Science, Curtin University , Bentley, Western Australia, Australia .
authors.forename: Silvia
authors.initials: S
authors.lastname: Lee
authors.affiliation: 4 School of Pathology and Laboratory Medicine, University of Western Australia , Perth, Western Australia, Australia .
authors.forename: Sara
authors.initials: S
authors.lastname: Tanaskovic
authors.affiliation: 2 Department of Internal Medicine, Medical Faculty, University of Indonesia , Cipto Mangunkusumo Hospital, Jakarta, Indonesia .|5 School of Biomedical Science, Curtin University , Bentley, Western Australia, Australia .|6 Curtin Health Innovation Research Institute-Biosciences, Curtin University , Bentley, Western Australia, Australia .
authors.forename: Patricia
authors.initials: P
authors.lastname: Price
mesh_terms: D000293:Adolescent; D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D003142:Communication; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000473:pathology*; D006801:Humans; D007214:Indonesia; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D054367:Receptors, CXCR3 / Q000032:analysis*; D013601:T-Lymphocytes / Q000737:chemistry*; D055815:Young Adult
chemical_list: D044966:Anti-Retroviral Agents; C515187:CXCR3 protein, human; D054367:Receptors, CXCR3
keywords: HIV; antiretroviral therapy; chemokine; hepatitis; hepatitis C