title: Relation of Stature to Outcomes in Korean Patients Undergoing Primary Percutaneous Coronary Intervention for Acute ST-Elevation Myocardial Infarction (from the INTERSTELLAR Registry).
abstract: Although epidemiologic studies have shown the impact of height on occurrence and/or prognosis of cardiovascular diseases, the underlying mechanism is unclear. In addition, the relation in patients with ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI) remains unknown. We sought to assess the influence of height on outcomes of patients with acute STEMI undergoing primary PCI and to provide a pathophysiological explanation. All 1,490 patients with STEMI undergoing primary PCI were analyzed. Major adverse cardiac and cerebrovascular events (MACCE) were defined as all-cause mortality, nonfatal myocardial infarction, nonfatal stroke, and unplanned hospitalization for heart failure (HF). Patients were divided into (1) MACCE (+) versus MACCE (-) and (2) first- to third-tertile groups according to height. MACCE (+) group was shorter than MACCE (-) group (164 ± 8 vs 166 ± 8 cm, p = 0.012). Prognostic impact of short stature was significant in older (≥70 years) male patients even after adjusting for co-morbidities (hazard ratio 0.951, 95% confidence interval 0.912 to 0.991, p = 0.017). The first-tertile group showed the worst MACCE-free survival (p = 0.035), and most cases of MACCE were HF (n, 17 [3%] vs 6 [1%] vs 2 [0%], p = 0.004). On post-PCI echocardiography, left atrial volume and early diastolic mitral velocity to early diastolic mitral annulus velocity ratio showed an inverse relation with height (p <0.001 for all) despite similar left ventricular ejection fraction. In conclusion, short stature is associated with occurrence of HF after primary PCI for STEMI, and its influence is prominent in aged male patients presumably for its correlation with diastolic dysfunction.
authors.affiliation: Department of Cardiology, Gachon University Gil Medical Center, Incheon, Republic of Korea.
authors.forename: Jeonggeun
authors.initials: J
authors.lastname: Moon
authors.affiliation: Department of Cardiology, Soon Chun Hyang University Bucheon Hospital, Bucheon, Republic of Korea.
authors.forename: Jon
authors.initials: J
authors.lastname: Suh
authors.affiliation: Department of Cardiology, Gachon University Gil Medical Center, Incheon, Republic of Korea.
authors.forename: Pyung Chun
authors.initials: PC
authors.lastname: Oh
authors.affiliation: Department of Cardiology, Gachon University Gil Medical Center, Incheon, Republic of Korea.
authors.forename: Kyounghoon
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Cardiology, Soon Chun Hyang University Bucheon Hospital, Bucheon, Republic of Korea.
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Park
authors.affiliation: Department of Cardiology, Sejong General Hospital, Bucheon, Republic of Korea.
authors.forename: Ho-Jun
authors.initials: HJ
authors.lastname: Jang
authors.affiliation: Department of Cardiology, Sejong General Hospital, Bucheon, Republic of Korea.
authors.forename: Tae-Hoon
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Cardiology, Inha University Hospital, Incheon, Republic of Korea.
authors.forename: Sang-Don
authors.initials: SD
authors.lastname: Park
authors.affiliation: Department of Cardiology, Inha University Hospital, Incheon, Republic of Korea.
authors.forename: Sung Woo
authors.initials: SW
authors.lastname: Kwon
authors.affiliation: Department of Cardiology, Gachon University Gil Medical Center, Incheon, Republic of Korea. Electronic address: kangwch@gilhospital.com.
authors.forename: Woong Chol
authors.initials: WC
authors.lastname: Kang
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D001827:Body Height; D002318:Cardiovascular Diseases; D004452:Echocardiography; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000473:pathology; D006333:Heart Failure / Q000453:epidemiology; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D009026:Mortality; D009203:Myocardial Infarction / Q000453:epidemiology; D009929:Organ Size; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D016016:Proportional Hazards Models; D056910:Republic of Korea; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000601:surgery*; D012737:Sex Factors; D020521:Stroke / Q000453:epidemiology; D013318:Stroke Volume; D016896:Treatment Outcome