title: Nomogram for hepatic steatosis: A simple and economical diagnostic tool for massive screening.
abstract: OBJECTIVE
  To establish a simple economical diagnostic tool for prediction of hepatic steatosis in patients with hepatitis B virus (HBV) infection.
  
  
  METHODS
  From January 2006 to January 2015,a total of 1325 consecutive subjects who underwent liver biopsy were enrolled. According to the results of multivariate logistic regression analysis, a new nomogram was conducted. Then discrimination and calibration were conducted to assess the clinical diagnostic value of nomogram.
  
  
  RESULTS
  The nomogram consisted of age, triglyceride (TG), low-density lipoprotein (LDL), uric acid (UA), haemoglobin (HGB). For prediction of hepatic steatosis, the AUROC of nomogram was 0.792 (95%CI: 0.758-0.826). With cut off value of 0.11, 699 (52.8%) of 1325 patients could be free from liver biopsy with a correct rate of 95.3% for diagnosis of hepatic steatosis.
  
  
  CONCLUSIONS
  The nomogram for hepatic steatosis has a better clinical diagnostic value for prediction of hepatic steatosis in patients with HBV infection. From the perspective of cost-effectiveness and clinical practice, it is worth considering the use of the nomogram as a mass screening tool before further liver biopsy or imaging examinations.
authors.affiliation: Department of Infectious Diseases, The Shunde First People's Hospital, Shunde, Guangdong, China.
authors.forename: Zhi-Qiao
authors.initials: ZQ
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, The Shunde First People's Hospital, Shunde, Guangdong, China.
authors.forename: Gong-Sui
authors.initials: GS
authors.lastname: Wang
authors.affiliation: Department of Pathology, The Shunde First People's Hospital, Shunde, Guangdong, China.
authors.forename: Kai-Fu
authors.initials: KF
authors.lastname: Kang
authors.affiliation: Department of Pathology, The Shunde First People's Hospital, Shunde, Guangdong, China.
authors.forename: Guo-Biao
authors.initials: GB
authors.lastname: Wu
authors.affiliation: Department of Infectious Diseases, The Shunde First People's Hospital, Shunde, Guangdong, China. Electronic address: sdgrxjbk@163.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
mesh_terms: D000328:Adult; D002681:China; D005234:Fatty Liver / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D008099:Liver / Q000473:pathology; D016015:Logistic Models; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D015999:Multivariate Analysis; D049451:Nomograms; D012372:ROC Curve; D012307:Risk Factors; D055815:Young Adult
keywords: Diagnosis; Fatty liver; Hepatitis B virus; Nomogram; Steatosis