title: CXCR4 and CCR7: Two eligible targets in targeted cancer therapy.
abstract: Cancer is one of the most common cause of death in the world with high negative emotional, economic, and social impacts. Conventional therapeutic methods, including chemotherapy and radiotherapy, have not proven satisfactory and relapse is common in most cases. Recent studies have focused on targeted therapy with more precise identification and targeted attacks to the cancer cells. For this purpose, chemokine receptors are proper targets and among them, CXCR4 and CCR7, with a crucial role in cancer metastasis, are being considered as desired candidates for investigation. In this review paper, the most important experimental results are highlighted on the potential targeted therapies based on CXCR4 and CCR7 chemokine receptors.
authors.affiliation: Department of Biology, Ferdowsi University of Mashhad, Mashhad, Iran.
authors.forename: Mohammad Amir
authors.initials: MA
authors.lastname: Mishan
authors.affiliation: Cancer Prevention Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Ahmadiankia
authors.affiliation: Department of Biology, Ferdowsi University of Mashhad, Mashhad, Iran.
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Bahrami
mesh_terms: D000818:Animals; D006801:Humans; D008207:Lymphatic Metastasis; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D054400:Receptors, CCR7 / Q000235:genetics / Q000378:metabolism*; D019718:Receptors, CXCR4 / Q000235:genetics / Q000378:metabolism*
chemical_list: C515370:CCR7 protein, human; C527276:CXCR4 protein, human; D054400:Receptors, CCR7; D019718:Receptors, CXCR4
keywords: CCR7; CXCR4; chemokine receptor; targeted cancer therapy