title: Phenotypic Screens in Antimalarial Drug Discovery.
abstract: Phenotypic high-throughput screens are a valuable tool for identifying new chemical compounds with antimalarial activity. Traditionally, these screens have focused solely on the symptomatic asexual blood stage of the parasite life cycle; however, to discover new medicines for malaria treatment and prevention, robust screening technologies against other parasite life-cycle stages are required. This review highlights recent advances and progress toward phenotypic screening methodologies over the past several years, with a focus on exoerythrocytic stage screens.
authors.affiliation: School of Medicine, Department of Pediatrics, Division of Host-Microbe Systems and Therapeutics, University of California, San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA.
authors.forename: Marisa L
authors.initials: ML
authors.lastname: Hovlid
authors.affiliation: School of Medicine, Department of Pediatrics, Division of Host-Microbe Systems and Therapeutics, University of California, San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: ewinzeler@ucsd.edu.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Winzeler
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical / Q000639:trends*; D006801:Humans; D008018:Life Cycle Stages / Q000187:drug effects*; D008288:Malaria / Q000188:drug therapy; D010641:Phenotype; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials
keywords: drug discovery; high-throughput screening; malaria; phenotypic screens