title: A successful case of an anaplastic meningioma treated with chemotherapy for soft tissue sarcomas.
abstract: Malignant meningioma has a bad prognosis. Surgery and radiotherapy are the most effective therapeutic options, without an established role for chemotherapy. We report a case of 2-year-old male child with diagnosis of postoperative relapse of a malignant meningioma. Considering the rapid progression, the young age and the lack of effective therapeutic alternatives, the patient underwent multidisciplinary anticancer treatment with a protocol made for soft tissue sarcomas (EpSSG NRSSTS 2005 protocol), with positive outcome. This case represents a successful management of an anaplastic meningioma with a multimodal treatment, including chemotherapy, in a pediatric patient.
authors.affiliation: Neuro-Oncology Unit, Department of Pediatric Oncology, Anna Meyer Children's University Hospital, Florence, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Lucchesi
authors.affiliation: Pathology Unit, Anna Meyer Children's University Hospital, Florence, Italy.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Buccoliero
authors.affiliation: Radiotherapy Unit, Careggi University Hospital, Florence, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Scoccianti
authors.affiliation: Neuro-Oncology Unit, Department of Pediatric Oncology, Anna Meyer Children's University Hospital, Florence, Italy.
authors.forename: Milena
authors.initials: M
authors.lastname: Guidi
authors.affiliation: Neuro-Oncology Unit, Department of Pediatric Oncology, Anna Meyer Children's University Hospital, Florence, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Farina
authors.affiliation: Neuro-Oncology Unit, Department of Pediatric Oncology, Anna Meyer Children's University Hospital, Florence, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Fonte
authors.affiliation: Neuro-Oncology Unit, Department of Pediatric Oncology, Anna Meyer Children's University Hospital, Florence, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Favre
authors.affiliation: Neurosurgery Unit, Department of Neuroscience, Anna Meyer Children's University Hospital, Florence, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Genitori
authors.affiliation: Neuro-Oncology Unit, Department of Pediatric Oncology, Anna Meyer Children's University Hospital, Florence, Italy.
authors.forename: Iacopo
authors.initials: I
authors.lastname: Sardi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy; D002675:Child, Preschool; D004317:Doxorubicin / Q000627:therapeutic use*; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008579:Meningioma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D012509:Sarcoma / Q000188:drug therapy
chemical_list: D004317:Doxorubicin; D007069:Ifosfamide
keywords: anaplastic meningioma; chemotherapy; pediatric solid tumors