title: One-Pot Copper(I)-Catalyzed Ligand/Base-Free Tandem Cyclooxidative Synthesis of Quinazolinones.
abstract: A novel and efficient Cu(I)-catalyzed ligand- and base-free multipathway domino strategy has been developed for the synthesis of 2-substituted quinazolinones. The reaction utilizes 2-bromobenzamide and multiform substrates such as aldehydes, alcohols, and methyl arenes for a one-pot protocol, whereas TMSN3 is used as a nitrogen source. A wide range of substrate scope, functional group tolerance, and operational simplicity are synthetically useful features.
authors.affiliation: Medicinal and Process Chemistry Division, ‡Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute (CSIR-CDRI) , Sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226031, India.
authors.forename: Kapil
authors.initials: K
authors.lastname: Upadhyaya
authors.affiliation: Medicinal and Process Chemistry Division, ‡Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute (CSIR-CDRI) , Sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226031, India.
authors.forename: Ravi Kumar
authors.initials: RK
authors.lastname: Thakur
authors.affiliation: Medicinal and Process Chemistry Division, ‡Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute (CSIR-CDRI) , Sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226031, India.
authors.forename: Sanjeev K
authors.initials: SK
authors.lastname: Shukla
authors.affiliation: Medicinal and Process Chemistry Division, ‡Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute (CSIR-CDRI) , Sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226031, India.
authors.forename: Rama Pati
authors.initials: RP
authors.lastname: Tripathi