title: Distinct Types of Feeding Related Neurons in Mouse Hypothalamus.
abstract: The last two decades of research provided evidence for a substantial heterogeneity among feeding-related neurons (FRNs) in the hypothalamus. However, it remains unclear how FRNs differ in their firing patterns during food intake. Here, we investigated the relationship between the activity of neurons in mouse hypothalamus and their feeding behavior. Using tetrode-based in vivo recording technique, we identified various firing patterns of hypothalamic FRNs, which, after the initiation of food intake, can be sorted into four types: sharp increase (type I), slow increase (type II), sharp decrease (type III), and sustained decrease (type IV) of firing rates. The feeding-related firing response of FRNs was rigidly related to the duration of food intake and, to a less extent, associated with the type of food. The majority of these FRNs responded to glucose and leptin and exhibited electrophysiological characteristics of putative GABAergic neurons. In conclusion, our study demonstrated the diversity of neurons in the complex hypothalamic network coordinating food intake.
authors.affiliation: Key Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), School of Life Science and the Collaborative Innovation Center for Brain Science, Institute of Brain Functional Genomics, East China Normal UniversityShanghai, China; Schaller Research Group on Neuropeptides at German Cancer Research Center, Central Institute of Mental Health, and Cell Networks Cluster of Excellence at the University of HeidelbergHeidelberg, Germany.
authors.forename: Yan
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Schaller Research Group on Neuropeptides at German Cancer Research Center, Central Institute of Mental Health, and Cell Networks Cluster of Excellence at the University of Heidelberg Heidelberg, Germany.
authors.forename: Diego
authors.initials: D
authors.lastname: Benusiglio
authors.affiliation: Schaller Research Group on Neuropeptides at German Cancer Research Center, Central Institute of Mental Health, and Cell Networks Cluster of Excellence at the University of Heidelberg Heidelberg, Germany.
authors.forename: Valery
authors.initials: V
authors.lastname: Grinevich
authors.affiliation: Key Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), School of Life Science and the Collaborative Innovation Center for Brain Science, Institute of Brain Functional Genomics, East China Normal University Shanghai, China.
authors.forename: Longnian
authors.initials: L
authors.lastname: Lin
keywords: feeding behavior; feeding-related neurons; firing patterns; food intake; hypothalamus; in vivo recording