title: Elevated periostin in serum and peritoneal washing fluids as potential biomarkers for endometriosis.
abstract: BACKGROUND
  To identify the level of periostin in serum and peritoneal washing fluids (PWF) from women with and without endometriosis, as well as to explore the potential of periostin as a biomarker of endometriosis.
  
  
  METHODS
  Samples were obtained from 184 women with and without endometriosis. Concentrations of periostin in PWF and blood were measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Levels of periostin both in serum and PWF were notably elevated in women with endometriosis in both the proliferative and secretory phase. Combined with dysmenorrhea and infertility, two potential covariates, the serum periostin had a sensitivity of 75.00%, specificity of 65.00%, and area under the curve (AUC) of 0.774, whereas the PWF periostin had a sensitivity of 94.23%, specificity of 90.00%, and AUC of 0.967 for the diagnosis of endometriosis.
  
  
  CONCLUSIONS
  Serum and PWF periostin concentrations may be new potential biomarkers for endometriosis, especially when combined with dysmenorrhea and infertility.
authors.affiliation: a Department of Obstetrics and Gynecology , Qilu Hospital of Shandong University , Jinan , People's Republic of China.
authors.forename: Qiaomei
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: a Department of Obstetrics and Gynecology , Qilu Hospital of Shandong University , Jinan , People's Republic of China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Lu
authors.affiliation: a Department of Obstetrics and Gynecology , Qilu Hospital of Shandong University , Jinan , People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: a Department of Obstetrics and Gynecology , Qilu Hospital of Shandong University , Jinan , People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Hu
authors.affiliation: a Department of Obstetrics and Gynecology , Qilu Hospital of Shandong University , Jinan , People's Republic of China.
authors.forename: Peishu
authors.initials: P
authors.lastname: Liu
mesh_terms: D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000097:blood / Q000378:metabolism*; D004715:Endometriosis / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; C512835:POSTN protein, human
keywords: Biomarker; dysmenorrhea; endometriosis; infertility; periostin