title: The evolutionary divergence of TRPA1 channel: heat-sensitive, cold-sensitive and temperature-insensitive.
abstract: The Transient Receptor Potential Ankyrin 1 ion channel is heat-sensitive in invertebrate and ancestral vertebrates, cold-sensitive in rodents, and temperature-insensitive in primates. This remarkable divergence in temperature sensitivity is in contrast to its role in sensing electrophilic compounds, which is conserved during animal evolution.
authors.affiliation: Biochemical Cellular Pharmacology; Genentech Inc. ; South San Francisco, CA, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
keywords: AITC, allyl isothiocyanate; TRPA1; TRPA1, Transient Receptor Potential Ankryin 1 ion channel; TRPM8, Transient Receptor Potential Melastatin 8 ion channel; TRPV1, Transient Receptor Potential Vanilloid 1 ion channel; activation; cold-sensitive; evolution; heat-sensitive; temperature-insensitive