title: Label-Free Imaging of Eosinophilic Esophagitis Mouse Models Using Optical Coherence Tomography.
abstract: Eosinophilic esophagitis (EoE) is an immune-mediated disorder characterized by esophageal inflammation and related structural changes causing symptoms such as feeding difficulties and food impaction. The pathophysiological mechanisms underlying EoE remain poorly understood. Preclinical studies using mouse models have been critical in comprehending human disease mechanisms and associated pathways. In this chapter, we describe an experimental method using a noninvasive label-free optical imaging technique, optical coherence tomography, to characterize the pathophysiological changes in the esophagus of mice with EoE-like disease ex vivo.
authors.affiliation: Department of Electrical and Computer Engineering, Packard Laboratory, Lehigh University, 19 Memorial Drive West, Bethlehem, PA, 18015, USA.|Center for Photonics and Nanoelectronics, Lehigh University, 19 Memorial Drive West, Bethlehem, PA, 18015, USA.
authors.forename: Aneesh
authors.initials: A
authors.lastname: Alex
authors.affiliation: Baker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.
authors.forename: Elia D
authors.initials: ED
authors.lastname: Tait Wojno
authors.affiliation: Jill Roberts Institute for Research in IBD, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, NY, 10021, USA.
authors.forename: David
authors.initials: D
authors.lastname: Artis
authors.affiliation: Department of Electrical and Computer Engineering, Packard Laboratory, Lehigh University, 19 Memorial Drive West, Bethlehem, PA, 18015, USA. chaozhou@lehigh.edu.|Center for Photonics and Nanoelectronics, Lehigh University, 19 Memorial Drive West, Bethlehem, PA, 18015, USA. chaozhou@lehigh.edu.|Bioengineering Program, Lehigh University, 19 Memorial Drive West, Bethlehem, PA, 18015, USA. chaozhou@lehigh.edu.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhou
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D057765:Eosinophilic Esophagitis / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D004947:Esophagus / Q000473:pathology*; D055785:Gene Knockdown Techniques; D006801:Humans; D007136:Immunoglobulins / Q000172:deficiency; D051379:Mice; D018121:Receptors, Cytokine / Q000172:deficiency; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D007136:Immunoglobulins; D018121:Receptors, Cytokine; C410591:Tslpr protein, mouse
keywords: EoE mouse models; Eosinophilic esophagitis; Gastrointestinal imaging; Label-free imaging; Optical coherence tomography; Optical imaging