title: A rare fatal case of a novel bunyavirus-associated hemophagocytic lymphohistiocytosis.
abstract: Herein we describe a rare fatal case of a novel bunyavirus-associated hemophagocytic lymphohistiocytosis (HLH) in a 62-year-old female patient. The novel bunyavirus infects patients with or without HLH who have similar clinical features such as fever, thrombocytopenia, and leukocytopenia. Therefore, the diagnosis of HLH can be easily missed. When HLH occurs, the disease worsens and the fatality rate rises. Our finding highlights the importance of bone marrow biopsy performed as soon as possible for patients suspected of having a novel bunyavirus infection and showing marked cytopenia in three cell lines.
authors.affiliation: Taizhou Hospital of Wenzhou Medical University, Linhai, China. nicedream00@163.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Lin
authors.forename: You-Zu
authors.initials: YZ
authors.lastname: Xu
authors.forename: Xiao-Mai
authors.initials: XM
authors.lastname: Wu
authors.forename: Hong-Fei
authors.initials: HF
authors.lastname: Ge
authors.forename: Jia-Xi
authors.initials: JX
authors.lastname: Feng
authors.forename: Mei-Fang
authors.initials: MF
authors.lastname: Chen
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Lv
authors.forename: Bo-Li
authors.initials: BL
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Lin
mesh_terms: D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D002044:Bunyaviridae Infections / Q000175:diagnosis* / Q000473:pathology* / Q000821:virology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D016851:Orthobunyavirus / Q000302:isolation & purification*