title: XPG Gene Polymorphisms and the Risk of Gastric Cardia Adenocarcinoma.
abstract: BACKGROUND
  Polymorphisms in DNA repair genes can alter an individual's DNA repair capability and contribute to the risk of various cancers.
  
  
  OBJECTIVE
  This study was designed to evaluate the association of single-nucleotide polymorphisms (SNPs) in the XPG gene with the risk of gastric cardia adenocarcinoma (GCA) in a high-incidence population in northern China.
  
  
  METHODS
  Two SNPs from 431 GCA patients and 432 healthy controls were genotyped using the polymerase chain reaction/ligase detection reaction (PCR-LDR) method.
  
  
  RESULTS
  The rs751402 C/T SNP T allele and the T/T genotype were associated with an increased risk of GCA in younger individuals (≤61 years) (odds ratio [OR] = 1.33 and 1.77, 95% confidence interval [CI] = 1.00-1.76 and 1.12-3.30, respectively). The rs873601 G/A SNP was not associated with susceptibility to GCA.
  
  
  CONCLUSIONS
  Our findings indicate that the rs751402 C/T SNP has potential as a predictive marker for the risk of GCA and that carriers of the T/T genotype should receive periodic upper gastrointestinal fiber tests to facilitate the early detection and early treatment of GCA.
authors.affiliation: 1 Hebei Provincial Cancer Institute, The Fourth Hospital of Hebei Medical University , Shijiazhuang, China .
authors.forename: Rong-Miao
authors.initials: RM
authors.lastname: Zhou
authors.affiliation: 2 Department of Surgery, Shijiazhuang Ping'an Hospital , Shijiazhuang, China .
authors.forename: Chao-Xu
authors.initials: CX
authors.lastname: Niu
authors.affiliation: 1 Hebei Provincial Cancer Institute, The Fourth Hospital of Hebei Medical University , Shijiazhuang, China .
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.affiliation: 1 Hebei Provincial Cancer Institute, The Fourth Hospital of Hebei Medical University , Shijiazhuang, China .
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.affiliation: 1 Hebei Provincial Cancer Institute, The Fourth Hospital of Hebei Medical University , Shijiazhuang, China .
authors.forename: Xi
authors.initials: X
authors.lastname: Huang
authors.affiliation: 1 Hebei Provincial Cancer Institute, The Fourth Hospital of Hebei Medical University , Shijiazhuang, China .
authors.forename: Zhi-Feng
authors.initials: ZF
authors.lastname: Chen
authors.affiliation: 1 Hebei Provincial Cancer Institute, The Fourth Hospital of Hebei Medical University , Shijiazhuang, China .
authors.forename: Xiang-Ran
authors.initials: XR
authors.lastname: Huo
authors.affiliation: 1 Hebei Provincial Cancer Institute, The Fourth Hospital of Hebei Medical University , Shijiazhuang, China .
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Hao
authors.affiliation: 1 Hebei Provincial Cancer Institute, The Fourth Hospital of Hebei Medical University , Shijiazhuang, China .
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D000328:Adult; D000368:Aged; D000483:Alleles; D002299:Cardia / Q000473:pathology*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D004720:Endonucleases / Q000235:genetics* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D000099250:DNA Excision Repair Protein ERCC-5
chemical_list: D004268:DNA-Binding Proteins; D004720:Endonucleases; D009687:Nuclear Proteins; D014157:Transcription Factors; D000099250:DNA Excision Repair Protein ERCC-5