title: Prediction of Outcome after Traumatic Brain Injury: Comparison of Disease State Index and IMPACT Calculator.
abstract: Traumatic brain injury (TBI) is a major cause of death and disability, especially in young adults. A reliable prediction of outcome after TBI is of great importance in clinical practice and research. We aimed to compare performance of the well-established IMPACT calculator and an alternative method, Disease State Index (DSI), in the prediction of six-month outcome after TBI. Performance of the models was evaluated using 2036 patients with moderate or severe TBI from the International Mission for Prognosis and Analysis of Clinical Trials in TBI (IMPACT) database. Prediction performance of both models was similar. The models with more variables provided better performance than the simpler models. This study showed that the DSI is a valid tool with efficient visualizations that can help clinicians with their decision making process in clinical practice.
authors.affiliation: VTT Technical Research Centre of Finland Ltd, Tampere, Finland.
authors.forename: Hilkka
authors.initials: H
authors.lastname: Liedes
authors.affiliation: VTT Technical Research Centre of Finland Ltd, Tampere, Finland.
authors.forename: Jussi
authors.initials: J
authors.lastname: Mattila
authors.affiliation: Erasmus Medical Centre, Rotterdam, The Netherlands.
authors.forename: Hester
authors.initials: H
authors.lastname: Lingsma
authors.affiliation: VTT Technical Research Centre of Finland Ltd, Tampere, Finland.
authors.forename: Jyrki
authors.initials: J
authors.lastname: Lötjönen
authors.affiliation: Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Menon
authors.affiliation: Division of Clinical Neurosciences, Department of Rehabilitation and Brain Trauma, Turku University Hospital, Turku, Finland.
authors.forename: Olli
authors.initials: O
authors.lastname: Tenovuo
authors.affiliation: VTT Technical Research Centre of Finland Ltd, Tampere, Finland.
authors.forename: Mark
authors.initials: M
authors.lastname: van Gils
mesh_terms: D000328:Adult; D000070642:Brain Injuries, Traumatic / Q000175:diagnosis* / Q000401:mortality; D003936:Diagnosis, Computer-Assisted / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D008297:Male; D063868:Patient Outcome Assessment; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index