title: Sequential Right and Left Ventricular Assessment in Posttetralogy of Fallot Patients with Significant Pulmonary Regurgitation.
abstract: BACKGROUND
  The natural history of right ventricular (RV) and left ventricular (LV) size and function among adults with tetralogy of Fallot (TOF) repair and hemodynamically significant pulmonary regurgitation (PR) is not known. The main aim of this study was to determine changes in RV and LV size and function over time in an adult population with TOF repair and hemodynamically significant pulmonary regurgitation.
  
  
  METHODS
  Forty patients with repaired TOF and hemodynamically significant PR were included. These patients were identified on the basis of having more than one CMR between January 2008 and 2015. Patients with a prosthetic pulmonary valve or any cardiac intervention between CMR studies were excluded. Rate of progression (ROP) of RV dilation was determined for both indexed right ventricular end-systolic volume (RVESVi) and indexed right ventricular end-diastolic volume (RVEDVi), and calculated as the difference between the last and first volumes divided by the number of years between CMR#1 and CMR#2. Subjects were also divided into two groups based on the distribution of the ROP of RV dilation: Group I-rapid ROP (>50th percentile) and Group II-slower ROP (≤50th percentile).
  
  
  RESULTS
  The interval between CMR#1 and CMR#2 was 3.9 ± 1.7 years (range 1-8 years). We did find a significant change in RVEDVi and RVESVi over this time period, although the magnitude of change was small. Nine patients (23%) had a reduction in right ventricular ejection fraction (RVEF) by greater than 5%, 13 patients (33%) had an increase in RVEDVi by greater than 10 mL/m2and seven patients (18%) had an increase in RVESVi by greater than 10 mL/m2. Median ROP for RVEDVi was 1.8 (range -10.4 to 21.8) mL/(m2year); RVESVi 1.1 (range -5.8 to 24.5) mL/(m2year) and RVEF -0.5 (range -8 to 4)%/year. Patients with a rapid ROP had significantly larger RV volumes at the time of CMR#1 and lower RVEF as compared to the slow ROP group. There was no overall significant change in LVEDVi, LVESVi, or LVEF over this time period.
  
  
  CONCLUSIONS
  We have demonstrated, in a small population of patients with hemodynamically significant PR, that there is a small increase in RV volumes and decrease in RVEF over a mean 4-year period. We believe it to be reasonable practice to perform CMR at least every 4 years in asymptomatic patients with repaired TOF and hemodynamically significant PR. We found that LV volumes and function remained stable during the study period, suggesting that significant progressive LV changes are less likely to occur over a shorter time period. Our results inform a safe standardized approach to monitoring adults with hemodynamically significant PR post TOF repair and assist in planning allocation of this expensive and limited resource.
authors.affiliation: Pacific Adult Congenital Heart Service, Division of Cardiology, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: Vishva A
authors.initials: VA
authors.lastname: Wijesekera
authors.affiliation: Department of Cardiac Imaging, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: Rekha
authors.initials: R
authors.lastname: Raju
authors.affiliation: Department of Cardiac Imaging, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: Bruce
authors.initials: B
authors.lastname: Precious
authors.affiliation: Department of Cardiac Imaging, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Berger
authors.affiliation: Pacific Adult Congenital Heart Service, Division of Cardiology, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: Marla C
authors.initials: MC
authors.lastname: Kiess
authors.affiliation: Department of Cardiac Imaging, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: Jonathon A
authors.initials: JA
authors.lastname: Leipsic
authors.affiliation: Pacific Adult Congenital Heart Service, Division of Cardiology, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: Jasmine
authors.initials: J
authors.lastname: Grewal
mesh_terms: D000293:Adolescent; D000328:Adult; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D016208:Databases, Factual; D018450:Disease Progression; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D017380:Hypertrophy, Right Ventricular / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D011665:Pulmonary Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D012189:Retrospective Studies; D013318:Stroke Volume; D013771:Tetralogy of Fallot / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right; D055815:Young Adult
keywords: Cardiac Magnetic Resonance Imaging; Left Ventricle; Pulmonary Regurgitation; Right Ventricle; Tetralogy of Fallot