title: Lack of Association between NYD-SP18 Variant and Obesity. The Health Alcohol and Psychosocial Factors in Eastern Europe Study.
abstract: To replicate the finding that the polymorphism rs6971091 within the NYD-SP18 gene is associated with body mass index (BMI).
  
  
  
  We analysed data of 29,284 adults (46.2% of males, mean age 58.9 (SD 7.3), mean BMI 28.6 (5.0 kg/m2)) examined within the Health Alcohol and Psychosocial Factors in Eastern Europe study in the Czech Republic, Poland, Lithuania and Russia.
  
  
  
  BMI did not differ by rs6971091 genotype. In men, the mean BMI (SEs) in GG, GA and AA carriers were 27.8 (0.05), 27.9 (0.06) and 27.9 (0.14) kg/m2, respectively, (p = 0.26); in women, the corresponding values were 29.2 (0.06), 29.1 (0.07) and 29.1 (0.16), p = 0.57. In Czech subjects (n = 6,752), for whom the FTO rs17817449 genotype was available, there was no interaction between the NYD-SP18 and FTO polymorphisms in determination of BMI. Adjustment for age, energy and fat intake and physical activity did not materially change the results. There was no association of the NYD-SP18 genotype with waist-hip ratio.
  
  
  
  This study in a large Slavonic population sample suggests that the rs6971091 variant within the NYD-SP18 gene is not an important determinant of obesity in middle-aged persons.
authors.affiliation: Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors.forename: Jaroslav A
authors.initials: JA
authors.lastname: Hubacek
authors.forename: Hynek
authors.initials: H
authors.lastname: Pikhart
authors.forename: Ruzena
authors.initials: R
authors.lastname: Kubinova
authors.forename: Anne
authors.initials: A
authors.lastname: Peasey
authors.forename: Sofia
authors.initials: S
authors.lastname: Malyutina
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pajak
authors.forename: Abdonas
authors.initials: A
authors.lastname: Tamosiunas
authors.forename: Martin
authors.initials: M
authors.lastname: Bobak
mesh_terms: D000368:Aged; D000483:Alleles; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000235:genetics / Q000378:metabolism; D015992:Body Mass Index; D015331:Cohort Studies; D018153:Czech Republic; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008097:Lithuania; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D009765:Obesity / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D050177:Overweight / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D012042:Registries; D015203:Reproducibility of Results; D012426:Russia; D049629:Waist-Hip Ratio
chemical_list: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D009687:Nuclear Proteins; C000625504:GARIN1B protein, human; C526492:FTO protein, human