title: Mitochondrial cAMP signaling.
abstract: Cyclic adenosine 3, 5'-monophosphate (cAMP) is a ubiquitous second messenger regulating many biological processes, such as cell migration, differentiation, proliferation and apoptosis. cAMP signaling functions not only on the plasma membrane, but also in the nucleus and in organelles such as mitochondria. Mitochondrial cAMP signaling is an indispensable part of the cytoplasm-mitochondrion crosstalk that maintains mitochondrial homeostasis, regulates mitochondrial dynamics, and modulates cellular stress responses and other signaling pathways. Recently, the compartmentalization of mitochondrial cAMP signaling has attracted great attentions. This new input should be carefully taken into account when we interpret the findings of mitochondrial cAMP signaling. In this review, we summarize previous and recent progress in our understanding of mitochondrial cAMP signaling, including the components of the signaling cascade, and the function and regulation of this signaling pathway in different mitochondrial compartments.
authors.affiliation: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 20892, USA.
authors.forename: Liping
authors.initials: L
authors.lastname: Zhang
authors.affiliation: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
authors.forename: Yun
authors.initials: Y
authors.lastname: Qi
authors.affiliation: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA. xuh5@nhlbi.nih.gov.
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
mesh_terms: D000818:Animals; D002451:Cell Compartmentation; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D015398:Signal Transduction
chemical_list: D000242:Cyclic AMP
keywords: AKAP; BH3; Drp1; Fission; PKA; Protein import; TFAM; mtDNA