title: Correlation of ischemia-modified albumin levels and histopathologic findings in experimental ovarian torsion.
abstract: OBJECTIVE
  Ischemia modified albumin (IMA) levels significantly increased and may be used as a diagnostic marker in ovarian torsion. The aim of this study is to investigate whether there was any correlation between IMA levels and histopathologic changes in experimental ovarian torsion.
  
  
  METHODS
  Fourteen Sprague-Dawley rats, each weighing 220-250 g were divided randomly into 2 groups; in Group 1, the control group (n = 7), only laparotomy was performed and in Group 2, the experimental group (n = 7), ovarian torsion was performed. Ischemia was performed for 3 h; following the ischemia period, the torsion was relieved by detwisting the adnexa and then the ovarian I/R protocol was applied for 3 h. Blood samples were taken from all of the rats to measure the IMA levels and the ovaries were surgically removed for histologic examination. A blinded pathologist examined and scored the samples.
  
  
  RESULTS
  The median (minimum-maximum) IMA values were 921.00 (870.00-966.00) ABSUs in the ovarian torsion group and 853.00 (782.00-869.00) ABSUs in the control group. The difference was statistically significant. In the correlation analysis, a significant and strong correlation was found between IMA levels and histopathologic changes (Spearman's rho = +0.987, p < 0.001).
  
  
  CONCLUSIONS
  Positive correlation was found between the IMA levels and the histopathologic severity of the disease. This finding is important for both diagnosis of the disease and patient follow-up. As a new marker in ovarian torsion, IMA may also indicate the severity of the ovarian histopathology.
authors.affiliation: Department of Emergency Medicine, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Yildirim
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Yildirim
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Naci
authors.initials: N
authors.lastname: Topaloglu
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Tekin
authors.affiliation: Department of Pediatric Surgery, Duzce Ataturk State Hospital, Duzce, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Kucuk
authors.affiliation: Department of Pathology, Faculty of Medicine, Duzce University, Duzce, Turkey.
authors.forename: Havva
authors.initials: H
authors.lastname: Erdem
authors.affiliation: Department of Anaesthesiology, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Erbas
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Dilek Ulker
authors.initials: DU
authors.lastname: Cakir
keywords: Ischemia-modified albumin; Ovary; Pathology; Rats