title: Medications associated with geriatric syndromes and their prevalence in older hospitalized adults discharged to skilled nursing facilities.
abstract: More than half of the hospitalized older adults discharged to skilled nursing facilities (SNFs) have more than 3 geriatric syndromes. Pharmacotherapy may be contributing to geriatric syndromes in this population.
  
  
  
  Develop a list of medications associated with geriatric syndromes and describe their prevalence in patients discharged from acute care to SNFs.
  
  
  
  Literature review and multidisciplinary expert panel discussion, followed by cross-sectional analysis.
  
  
  
  Academic medical center in the United States PARTICIPANTS: One hundred fifty-four hospitalized Medicare beneficiaries discharged to SNFs.
  
  
  
  Development of a list of medications that are associated with 6 geriatric syndromes. Prevalence of the medications associated with geriatric syndromes was examined in the hospital discharge sample.
  
  
  
  A list of 513 medications was developed as potentially contributing to 6 geriatric syndromes: cognitive impairment, delirium, falls, reduced appetite or weight loss, urinary incontinence, and depression. Medications included 18 categories. Antiepileptics were associated with all syndromes, whereas antipsychotics, antidepressants, antiparkinsonism, and opioid agonists were associated with 5 geriatric syndromes. In the prevalence sample, patients were discharged to SNFs with an overall average of 14.0 (±4.7) medications, including an average of 5.9 (±2.2) medications that could contribute to geriatric syndromes, with falls having the most associated medications at discharge at 5.5 (±2.2).
  
  
  
  Many commonly prescribed medications are associated with geriatric syndromes. Over 40% of all medications ordered upon discharge to SNFs were associated with geriatric syndromes and could be contributing to the high prevalence of geriatric syndromes experienced by this population. Journal of Hospital Medicine 2016;11:694-700. © 2016 Society of Hospital Medicine.
authors.affiliation: Center for Quality Aging, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.|Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Avantika A
authors.initials: AA
authors.lastname: Saraf
authors.affiliation: School of Medicine, Vanderbilt University, Nashville, Tennessee.
authors.forename: Alec W
authors.initials: AW
authors.lastname: Petersen
authors.affiliation: Center for Quality Aging, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.|Division of Geriatrics, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.|Geriatric Research, Education and Clinical Center, VA Tennessee Valley Healthcare System, Nashville, Tennessee.
authors.forename: Sandra F
authors.initials: SF
authors.lastname: Simmons
authors.affiliation: Center for Quality Aging, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.|Division of Geriatrics, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.|Geriatric Research, Education and Clinical Center, VA Tennessee Valley Healthcare System, Nashville, Tennessee.
authors.forename: John F
authors.initials: JF
authors.lastname: Schnelle
authors.affiliation: Center for Quality Aging, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.|Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.|Division of Geriatrics, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Susan P
authors.initials: SP
authors.lastname: Bell
authors.affiliation: Section of Hospital Medicine, Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.|Center for Clinical Quality and Implementation Research, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Sunil
authors.initials: S
authors.lastname: Kripalani
authors.affiliation: Department of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Amy P
authors.initials: AP
authors.lastname: Myers
authors.affiliation: Geriatric Research, Education and Clinical Center, VA Tennessee Valley Healthcare System, Nashville, Tennessee.|Section of Hospital Medicine, Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.|Center for Clinical Quality and Implementation Research, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Amanda S
authors.initials: AS
authors.lastname: Mixon
authors.affiliation: Center for Quality Aging, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Emily A
authors.initials: EA
authors.lastname: Long
authors.affiliation: Center for Quality Aging, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.|Geriatric Research, Education and Clinical Center, VA Tennessee Valley Healthcare System, Nashville, Tennessee.
authors.forename: J Mary Lou
authors.initials: JM
authors.lastname: Jacobsen
authors.affiliation: Center for Quality Aging, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. ed.vasilevskis@vanderbilt.edu.|Geriatric Research, Education and Clinical Center, VA Tennessee Valley Healthcare System, Nashville, Tennessee. ed.vasilevskis@vanderbilt.edu.|Section of Hospital Medicine, Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. ed.vasilevskis@vanderbilt.edu.
authors.forename: Eduard E
authors.initials: EE
authors.lastname: Vasilevskis
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D010351:Patient Discharge; D019338:Polypharmacy; D015995:Prevalence; D012866:Skilled Nursing Facilities; D014481:United States