title: Symptomatic Management of Multiple Sclerosis-Associated Tremor Among Participants in the NARCOMS Registry.
abstract: BACKGROUND
  Tremor affects 25% to 58% of patients with multiple sclerosis (MS) and is associated with poor prognosis and increased disability. MS-related tremor is difficult to treat, and data regarding patient-reported characterization and response to treatment are limited. We describe the symptomatic treatment of tremor in 508 enrollees in the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry who self-reported tremor.
  
  
  METHODS
  From 777 surveys sent to NARCOMS participants who indicated mild or greater tremor using the Tremor and Coordination Scale, we compiled data regarding disability, tremor severity, symptomatic medication use, and reported response to medications.
  
  
  RESULTS
  Symptomatic medications reported to reduce tremor were used by 238 respondents (46.9%). Symptomatic medication use was associated with increased rates of unemployment and disability, and many other characteristics were similar between groups. Symptomatic drug use was more likely in participants reporting moderate (53.9%) or severe (51.3%) tremor than in those with mild (36.6%) or totally disabling (35.0%) tremor. This disparity held true across multiple tremor severity scores. The most commonly used drug classes were anticonvulsants (50.8%) and benzodiazepines (46.2%), with gabapentin and clonazepam used most often in their respective classes.
  
  
  CONCLUSIONS
  Tremor in MS remains poorly treated; less than half of the participants reported benefit from symptomatic medications. Patients with moderate-to-severe tremor are more likely to report tremor benefit than are those with mild or disabling tremor. γ-Aminobutyric acid-active medications were most commonly reported as beneficial.
authors.affiliation: Department of Neurology (WM, JRR) and the Department of Biostatistics (ARS), University of Alabama at Birmingham, Birmingham, AL, USA; and Birmingham VA Medical Center, Birmingham, AL, USA (WM, JRR).
authors.forename: William
authors.initials: W
authors.lastname: Meador
authors.affiliation: Department of Neurology (WM, JRR) and the Department of Biostatistics (ARS), University of Alabama at Birmingham, Birmingham, AL, USA; and Birmingham VA Medical Center, Birmingham, AL, USA (WM, JRR).
authors.forename: Amber R
authors.initials: AR
authors.lastname: Salter
authors.affiliation: Department of Neurology (WM, JRR) and the Department of Biostatistics (ARS), University of Alabama at Birmingham, Birmingham, AL, USA; and Birmingham VA Medical Center, Birmingham, AL, USA (WM, JRR).
authors.forename: John R
authors.initials: JR
authors.lastname: Rinker