title: Somatostatin Receptor-Mediated Tumor-Targeting Nanocarriers Based on Octreotide-PEG Conjugated Nanographene Oxide for Combined Chemo and Photothermal Therapy.
abstract: Nano-sized in vivo active targeting drug delivery systems have been developed to a high anti-tumor efficacy strategy against certain cancer-cells-specific. Graphene based nanocarriers with unique physical and chemical properties have shown significant potentials in this aspect. Here, octreotide (OCT), an efficient biotarget molecule, is conjugated to PEGylated nanographene oxide (NGO) drug carriers for the first time. The obtained NGO-PEG-OCT complex shows low toxicity and excellent stability in vivo and is able to achieve somatostatin receptor-mediated tumor-specific targeting delivery. Owing to the high loading efficiency and accurate targeting delivery of anti-cancer drug doxorubicin (DOX), our DOX loaded NGO-PEG-OCT complex offers a remarkably improved cancer-cell-specific cellular uptake, chemo-cytotoxicity, and decreased systemic toxicity compared to free DOX or NGO-PEG. More importantly, due to its strong near-infrared absorption, the NGO-PEG-OCT complex further enhances efficient photothermal ablation of tumors, delivering combined chemo and photothermal therapeutic effect against cancer cells.
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, No. 24 Tong Jia Xiang, Nanjing, 210009, China.
authors.forename: Xuyuan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD, 20742, USA.
authors.forename: Chongyin
authors.initials: C
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, No. 24 Tong Jia Xiang, Nanjing, 210009, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, No. 24 Tong Jia Xiang, Nanjing, 210009, China.
authors.forename: Meirong
authors.initials: M
authors.lastname: Huo
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism; D002470:Cell Survival; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D004337:Drug Carriers; D000067493:Dynamic Light Scattering; D005260:Female; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D015282:Octreotide / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D017481:Receptors, Somatostatin / Q000378:metabolism*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D017481:Receptors, Somatostatin; D011092:Polyethylene Glycols; D006108:Graphite; D004317:Doxorubicin; D015282:Octreotide
keywords: cancer therapy; graphene oxide; octreotide; photothermal therapy; somatostatin receptors; tumor targeting