title: Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia.
authors.affiliation: Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.|Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: B M
authors.initials: BM
authors.lastname: Richine
authors.affiliation: Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.|Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: E L
authors.initials: EL
authors.lastname: Virts
authors.affiliation: Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Bowling
authors.affiliation: Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.|Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: B
authors.initials: B
authors.lastname: Ramdas
authors.affiliation: Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.|Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: R
authors.initials: R
authors.lastname: Mali
authors.affiliation: Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: R
authors.initials: R
authors.lastname: Naoye
authors.affiliation: Department of Biostatistics, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Medicinal Chemistry & Molecular Pharmacology, Purdue College of Pharmacy, West Lafayette, IN, USA.
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Zhang
authors.affiliation: Department of Medicine, Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: H S
authors.initials: HS
authors.lastname: Boswell
authors.affiliation: Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.|Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.|Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.|Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: R
authors.initials: R
authors.lastname: Kapur
authors.affiliation: Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.|Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.|Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Chan
mesh_terms: D000595:Amino Acid Sequence; D049109:Cell Proliferation; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism / Q000473:pathology*; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000037:antagonists & inhibitors*; D050799:STAT5 Transcription Factor / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D000072377:Syk Kinase / Q000037:antagonists & inhibitors*; D051941:fms-Like Tyrosine Kinase 3 / Q000737:chemistry / Q000502:physiology*
chemical_list: D004791:Enzyme Inhibitors; D050799:STAT5 Transcription Factor; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3; D000072377:Syk Kinase; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11