title: [Alteration of intestinal permeability: the missing link between gut microbiota modifications and inflammation in obesity?].
abstract: The increasing incidence of obesity and associated metabolic complications is a worldwide public health issue. The role of the gut in the pathophysiology of obesity, with an important part for microbiota, is becoming obvious. In rodent models of diet-induced obesity, the modifications of gut microbiota are associated with an alteration of the intestinal permeability increasing the passage of food or bacterial antigens, which contribute to low-grade inflammation and insulin resistance. In human obesity, intestinal permeability modification, and its role in the crosstalk between gut microbiota changes and inflammation at systemic and tissular levels, are still poorly documented. Hence, further characterization of the triggering mechanisms of such inflammatory responses in obese subjects could enable the development of personalized intervention strategies that will help to reduce the risk of obesity-associated diseases.
authors.affiliation: Institut de cardiométabolisme et nutrition, ICAN, hôpital Pitié-Salpêtrière, F-75013, Paris, France - Sorbonne universités, université Paris 06, UMR-S 1166, Nutriomics Team, F-75013 Paris, France - Inserm, UMRS 1166, Nutriomics, F-75013 5Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Genser
authors.affiliation: Institut de cardiométabolisme et nutrition, ICAN, hôpital Pitié-Salpêtrière, F-75013, Paris, France - Sorbonne universités, université Paris 06, UMR-S 1166, Nutriomics Team, F-75013 Paris, France - Inserm, UMRS 1166, Nutriomics, F-75013 5Paris, France - Assistance-Publique Hôpitaux de Paris, groupe hospitalier Pitié-Salpêtrière, service de nutrition, 47-83, boulevard de l'Hôpital, F-75013 Paris, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Poitou
authors.affiliation: Institut de cardiométabolisme et nutrition, ICAN, hôpital Pitié-Salpêtrière, F-75013, Paris, France - Centre de recherche des Cordeliers, Inserm, UMPC université Paris 6, université Paris Descartes Paris 5, CNRS, EPHE laboratoire de pharmacologie cellulaire et moléculaire, 75006 Paris, France.
authors.forename: Édith
authors.initials: É
authors.lastname: Brot-Laroche
authors.affiliation: Institut de cardiométabolisme et nutrition, ICAN, hôpital Pitié-Salpêtrière, F-75013, Paris, France - Centre de recherche des Cordeliers, Inserm, UMPC université Paris 6, université Paris Descartes Paris 5, CNRS, EPHE laboratoire de pharmacologie cellulaire et moléculaire, 75006 Paris, France.
authors.forename: Monique
authors.initials: M
authors.lastname: Rousset
authors.affiliation: Assistance-Publique Hôpitaux de Paris, groupe hospitalier Pitié-Salpêtrière, service de chirurgie digestive, hépato-bilio-pancréatique, transplantation hépatique, F-75013 Paris, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Vaillant
authors.affiliation: Institut de cardiométabolisme et nutrition, ICAN, hôpital Pitié-Salpêtrière, F-75013, Paris, France - Sorbonne universités, université Paris 06, UMR-S 1166, Nutriomics Team, F-75013 Paris, France - Inserm, UMRS 1166, Nutriomics, F-75013 5Paris, France - Assistance-Publique Hôpitaux de Paris, groupe hospitalier Pitié-Salpêtrière, service de nutrition, 47-83, boulevard de l'Hôpital, F-75013 Paris, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Clément
authors.affiliation: Institut de cardiométabolisme et nutrition, ICAN, hôpital Pitié-Salpêtrière, F-75013, Paris, France - Centre de recherche des Cordeliers, Inserm, UMPC université Paris 6, université Paris Descartes Paris 5, CNRS, EPHE laboratoire de pharmacologie cellulaire et moléculaire, 75006 Paris, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Thenet
authors.affiliation: Institut de cardiométabolisme et nutrition, ICAN, hôpital Pitié-Salpêtrière, F-75013, Paris, France - Centre de recherche des Cordeliers, Inserm, UMPC université Paris 6, université Paris Descartes Paris 5, CNRS, EPHE laboratoire de pharmacologie cellulaire et moléculaire, 75006 Paris, France.
authors.forename: Armelle
authors.initials: A
authors.lastname: Leturque
mesh_terms: D000818:Animals; D064806:Dysbiosis / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000378:metabolism / Q000382:microbiology; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000382:microbiology; D007422:Intestines / Q000276:immunology / Q000382:microbiology; D009765:Obesity / Q000209:etiology* / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D010539:Permeability