title: [OPTICAL BIOPSY FOR DIAGNOSIS OF ESOPHAGEAL MUCOSAL CHANGES IN CHILDREN].
abstract: OBJECTIVE
  To analyze the value of confocal laser endomicroscopy in diagnostics of upper gastrointestinal tract mucosa changes in children.
  
  
  METHODS
  In the current study a total of 116 children aged from 3 to 18 years old undergo conventional endoscopy with confocal laser endomicroscopy supplemented with mucosal biopsy followed by traditional histology in the period from 2011 until 2014. To determine the prognostic value of the of probe based CLE in the evaluation of normal and pathological changes of the esophageal mucosa a comparison of results of optical biopsy with the data obtained during the standard histological examination were performed.
  
  
  RESULTS
  After results of probe-based CLE and traditional histology were comprised optical biopsy showed 88.8% sensitivity and 88.3% specificity to esophagitis with Spearmen correlation 0.79 (p = 0.001); 92.3% sensitivity and 95.3% specificity to metaplastic changes of esophageal mucosa with Spearmen correlation 0.85 (p = 0.001); 92.4% sensitivity and 95.2% specificity in differential diagnosis of esophageal polyps with Spearmen correlation 0.95 (p = 0.001).
  
  
  CONCLUSIONS
  Confocal endomicroscopy may become one of the leading methods in pediatric gastroenterology since it allows the endoscopists to inspect the mucosa at the cellular level during the endoscopic procedure and can help in establishing the diagnosis.
authors.forename: A A
authors.initials: AA
authors.lastname: Shavrov
authors.forename: G V
authors.initials: GV
authors.lastname: Volynets
authors.forename: A A
authors.initials: AA
authors.lastname: Shavrov
authors.forename: A I
authors.initials: AI
authors.lastname: Khavkin
authors.forename: A G
authors.initials: AG
authors.lastname: Talalaev
authors.forename: S G
authors.initials: SG
authors.lastname: Khomeriki
authors.forename: A Y
authors.initials: AY
authors.lastname: Kharitonova
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D003937:Diagnosis, Differential; D016145:Endoscopy, Digestive System / Q000379:methods*; D004935:Esophageal Diseases / Q000473:pathology*; D004947:Esophagus / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal / Q000379:methods*; D018715:Microscopy, Video / Q000379:methods; D009092:Mucous Membrane / Q000473:pathology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity