title: Impact of a regimented aminophylline administration protocol on the burden of regadenoson-induced ischemia detected by SPECT myocardial perfusion imaging.
abstract: In patients undergoing regadenoson SPECT myocardial perfusion imaging (MPI), it is unknown how soon and at which dose intravenous aminophylline can be administered to reverse regadenoson-related adverse effects without blunting stress-induced myocardial ischemia.
  
  
  
  We analyzed the pooled database of the ASSUAGE and ASSUAGE-CKD trials (n = 548). These were double-blinded, placebo-controlled, randomized clinical trials in which 75 mg of aminophylline or placebo was administered intravenously 90 seconds following99mTc-tetrofosmin injection. There were no statistically significant differences in summed difference score (SDS) burden (P = .87) and in the rates of myocardial ischemia (SDS ≥ 2) (P = .93) between the aminophylline (n = 274) and placebo (n = 274) groups. There was no interaction between aminophylline use and SDS as a determinant of the composite endpoint of cardiac death or MI (P = .32) or the composite endpoint of cardiac death, MI, or coronary revascularization (P = .92).
  
  
  
  In patients undergoing regadenoson-stress SPECT-MPI, the intravenous administration of 75 mg of aminophylline as early as 90 seconds after radioisotope injection does not seem to attenuate the burden of myocardial ischemia.
authors.affiliation: Division of Cardiology, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Ibtihaj
authors.initials: I
authors.lastname: Fughhi
authors.affiliation: Division of Cardiology, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Tania
authors.initials: T
authors.lastname: Campagnoli
authors.affiliation: Division of Cardiology, John H. Stroger, Jr. Hospital of Cook County, 1901 W. Harrison St, Chicago, IL, 60612, USA.
authors.forename: Amjad
authors.initials: A
authors.lastname: Ali
authors.affiliation: Division of Cardiology, Rush University Medical Center, Chicago, IL, USA. rami_doukky@rush.edu.|Division of Cardiology, John H. Stroger, Jr. Hospital of Cook County, 1901 W. Harrison St, Chicago, IL, 60612, USA. rami_doukky@rush.edu.|Department of Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL, USA. rami_doukky@rush.edu.
authors.forename: Rami
authors.initials: R
authors.lastname: Doukky
mesh_terms: D061605:Administration, Intravenous; D000368:Aged; D000628:Aminophylline / Q000008:administration & dosage*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D055414:Myocardial Perfusion Imaging; D009943:Organophosphorus Compounds / Q000008:administration & dosage; D015609:Organotechnetium Compounds / Q000008:administration & dosage; D011446:Prospective Studies; D011687:Purines / Q000009:adverse effects*; D011720:Pyrazoles / Q000009:adverse effects*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D011687:Purines; D011720:Pyrazoles; D000628:Aminophylline; C430916:regadenoson; C078700:technetium tc-99m tetrofosmin
keywords: Regadenoson; SPECT; aminophylline; ischemia; myocardial perfusion imaging (MPI)