title: Bioinformatics Based Approaches to Study Virus-Host Interactions During Chikungunya Virus Infection.
abstract: The limitations of high-throughput genomic methods used for studying virus-host interactions make it difficult to directly obtain insights on virus pathogenesis. In this chapter, the central steps of a protein structure similarity based computational approach used to predict the host interactors of Chikungunya virus are explained by highlighting the important aspects that need to be considered. Identification of such conserved set of putative interactions that allow the virus to take control of the host has the potential to deepen our understanding of the virus-specific remodeling processes of the host cell and illuminate new arenas of disease intervention.
authors.affiliation: Centre for Emerging Diseases, Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector 62, Noida, 201307, Uttar Pradesh, India.
authors.forename: Sreejith
authors.initials: S
authors.lastname: Rajasekharan
authors.affiliation: Centre for Emerging Diseases, Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector 62, Noida, 201307, Uttar Pradesh, India. sanjay.gupta@jiit.ac.in.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000818:Animals; D065632:Chikungunya Fever / Q000378:metabolism* / Q000821:virology; D002646:Chikungunya virus / Q000502:physiology*; D019295:Computational Biology / Q000379:methods*; D029721:Drosophila Proteins / Q000737:chemistry / Q000378:metabolism; D004331:Drosophila melanogaster / Q000378:metabolism / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D011487:Protein Conformation; D060066:Protein Interaction Maps; D040681:Structural Homology, Protein; D014764:Viral Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D014764:Viral Proteins
keywords: Chikungunya virus; Protein interactions; Protein structure similarity; Structural bioinformatics; Virus–host interactions