title: Surgical Outcomes of Synchronous Multiple Primary Non-Small Cell Lung Cancers.
abstract: The prognostic indicators for synchronous multiple primary non-small cell lung cancer (NSCLC) vary across reports. In present study, the prognostic factors for the patients with synchronous multiple primary NSCLC were analyzed in a large cohort. A total of 285 patients with synchronous multiple primary NSCLC who underwent radical surgical resection and with complete follow-up information were included in this study. The Kaplan-Meier method were used for survival analysis, Cox proportional hazards regression models were used for risk factors evaluation. Among them, 94 (33.0%) patients had bilateral tumors and 51 (17.9%) had multiple (≥3) tumors. The 5-year disease-free survival (DFS) and overall survival (OS) rate was 58.7% and 77.6%, respectively. Univariate analysis identified parameters conferring shorter OS including male gender, symptomatic disease, negative family history, large maximal tumor size, not all adenocarcinomas, advanced highest T stage, and lymph node involvement. Multivariate analysis showed that male gender (p = 0.020), symptomatic disease (p = 0.017), and lymph node involvement (p < 0.001) were independent adverse prognosticators. For patients with multiple adenocarcinomas, the 5-year DFS and OS rate was 59.6% and 82.4%, respectively. The subtypes other than lepidic predominant (p < 0.001) and lymph node involvement (p = 0.002) were the independent unfavorable prognosticators. In conclusion, we identified independent prognosticators which will provide the valuable clues for postoperative management of patients with synchronous multiple primary NSCLC.
authors.affiliation: Department of Thoracic Surgery, Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, China.
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, China.
authors.forename: Shugeng
authors.initials: S
authors.lastname: Gao
authors.affiliation: Department of Thoracic Surgery, Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, China.
authors.forename: Yousheng
authors.initials: Y
authors.lastname: Mao
authors.affiliation: Department of Thoracic Surgery, Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, China.
authors.forename: Juwei
authors.initials: J
authors.lastname: Mu
authors.affiliation: Department of Thoracic Surgery, Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xue
authors.affiliation: Department of Pathology, Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Thoracic Surgery, Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College, China.
authors.forename: Jie
authors.initials: J
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007680:Kidney Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012737:Sex Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome