title: Imidazo[1,2-a]pyridine Scaffold as Prospective Therapeutic Agents.
abstract: Imidazo[1,2-a]pyridine is one of the most potential bicyclic 5-6 heterocyclic rings that is recognized as a "drug prejudice" scaffold due to its broad range of applications in medicinal chemistry such as anticancer, antimycobacterial, antileishmanial, anticonvulsant, antimicrobial, antiviral, antidiabetic, proton pump inhibitor, insecticidal activities. This scaffold has also been represented in various marketed preparations such as zolimidine, zolpidem, alpidem. Therefore, several attempts were made to carry out the structural modifications of this scaffold to discover and develop novel therapeutic agents. This review provides a valuable insight into the research findings of wide range of derivatives of imidazo[1,2-a]pyridine scaffold leading to promising heterocyclic compounds which could be explored further for the synthesis of new derivatives as well as construction of potential drug-like chemical libraries for biological screening in search of new therapeutic agents.
authors.forename: Aakash
authors.initials: A
authors.lastname: Deep
authors.forename: Richa Kaur
authors.initials: RK
authors.lastname: Bhatia
authors.forename: Ramanjot
authors.initials: R
authors.lastname: Kaur
authors.forename: Sanjiv
authors.initials: S
authors.lastname: Kumar
authors.forename: Upendra Kumar
authors.initials: UK
authors.lastname: Jain
authors.forename: Harinder
authors.initials: H
authors.lastname: Singh
authors.forename: Sandeep
authors.initials: S
authors.lastname: Batra
authors.forename: Dinesh
authors.initials: D
authors.lastname: Kaushik
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia.
authors.forename: Pran Kishore
authors.initials: PK
authors.lastname: Deb
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000890:Anti-Infective Agents; D011725:Pyridines; C001439:imidazo(1,2-a)pyridine