title: Systemic Thrombolysis for Ischemic Stroke after Antagonizing Dabigatran with Idarucizumab-A Case Report.
abstract: We here describe our experience of systemic thrombolysis therapy for severe ischemic stroke in a patient taking dabigatran for atrial fibrillation. After administration of the monoclonal antibody fragment idarucizumab, the anticoagulative effects of dabigatran were efficiently antagonized and application of alteplase was safe and feasible in our patient. This case report may illustrate a novel treatment option in the neurological emergency setting.
authors.affiliation: Department of Neurology, University of Bonn Medical Center, Bonn, Germany. Electronic address: niklas.schaefer@ukb.uni-bonn.de.
authors.forename: Niklas
authors.initials: N
authors.lastname: Schäfer
authors.affiliation: Department of Neuroradiology, University of Bonn Medical Center, Bonn, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Müller
authors.affiliation: Department of Neurology, University of Bonn Medical Center, Bonn, Germany.
authors.forename: Ullrich
authors.initials: U
authors.lastname: Wüllner
mesh_terms: D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000991:Antithrombins / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000150:complications / Q000000981:diagnostic imaging; D000069604:Dabigatran / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D020521:Stroke / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000991:Antithrombins; C000594745:idarucizumab; D000069604:Dabigatran
keywords: Idarucizumab; atrial fibrillation; dabigatran; ischemic stroke; systemic thrombolysis