title: Methylene blue-related corneal edema and iris discoloration.
abstract: We report the case of a 70-year-old female patient who developed corneal edema and iris discoloration following the inadvertent use of 1% methylene blue instead of 0.025% trypan blue to stain the anterior capsule during cataract phacoemulsification surgery. Copious irrigation was performed upon realization of incorrect dye use. Corneal edema and iris discoloration developed during the early postoperative period and persisted at 24-months follow-up. However, keratoplasty was not required. The intracameral use of 1% methylene blue has a cytotoxic effect on the corneal endothelium and iris epithelium. Copious irrigation for at least 30 min using an anterior chamber maintainer may improve outcomes.
authors.affiliation: Department of Ophthalmology, Istanbul Hospital, Van, Turkey.
authors.forename: Ozgur Bulent
authors.initials: OB
authors.lastname: Timucin
authors.affiliation: Department of Ophthalmology, Istanbul Hospital, Van, Turkey.
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Karadag
authors.affiliation: Department of Ophthalmology, School of Medicine, Uludag University, Bursa, Turkey.
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Aslanci
authors.affiliation: Department of Ophthalmology, School of Medicine, Uludag University, Bursa, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Baykara
mesh_terms: D000368:Aged; D004396:Coloring Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D015715:Corneal Edema / Q000209:etiology; D005260:Female; D006801:Humans; D007267:Injections; D007498:Iris / Q000187:drug effects; D019300:Medical Errors / Q000009:adverse effects*; D008751:Methylene Blue / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D018918:Phacoemulsification / Q000009:adverse effects* / Q000295:instrumentation; D007507:Therapeutic Irrigation / Q000379:methods; D014792:Visual Acuity
chemical_list: D004396:Coloring Agents; D008751:Methylene Blue