title: Controllable synthesis of dual-MOFs nanostructures for pH-responsive artemisinin delivery, magnetic resonance and optical dual-model imaging-guided chemo/photothermal combinational cancer therapy.
abstract: Theranostic nanoagents which integrate diagnostic and therapeutic moieties into a single platform have attracted broad attention in cancer therapy, however the development of more effective and less toxic diagnostic and therapeutic interventions is still of great urgency. Herein, novel core-shell PB@MIL-100(Fe) dual metal-organic-frameworks (d-MOFs) nanoparticles are fabricated and their combined theranostic effects in vitro and in vivo are investigated. The d-MOFs nanoparticles can serve as a T1-T2 dual-modal magnetic resonance imaging (MRI) contrast and fluorescence optical imaging (FOI) agent due to the existence of inner PB MOFs and outer MIL-100(Fe) MOFs. The artemisinin (a traditional Chinese anticancer medicine) with a high loading content of 848.4 mg/g is released from the d-MOFs upon tumor cellular endocytosis due to the pH-responsive degradation of outer MOFs in low pH lysosomes of tumor cells. Furthermore, the inner PB MOFs can be utilized for photothermal therapy due to its strong absorbance in NIR region. Under the guidance by such dual-modal imaging, in vivo photothermal and chemotherapy is finally carried out, achieving effective tumor ablation in an animal tumor model. Furthermore, histological analysis revealed that the drug delivery system had no obvious effect on the major organs of mice due to the low toxicity of both d-MOFs and artemisinin. The distinctive multimodal imaging capability, excellent synergistic therapy effect through the combined chemo-photothermal therapy together with the low toxicity of both d-MOFs and artemisinin endow the theranostic nanoagent a promising next generation of nanomedicine for efficient and safe cancer therapy.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, Department of Materials Science & Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, CAS High Magnetic Field Laboratory, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, Department of Materials Science & Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, CAS High Magnetic Field Laboratory, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Ruhui
authors.initials: R
authors.lastname: Chen
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, Department of Materials Science & Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, CAS High Magnetic Field Laboratory, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Ruohong
authors.initials: R
authors.lastname: Shi
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, Department of Materials Science & Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, CAS High Magnetic Field Laboratory, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Gaozheng
authors.initials: G
authors.lastname: Zhao
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, Department of Materials Science & Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, CAS High Magnetic Field Laboratory, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Xia
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, Department of Materials Science & Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, CAS High Magnetic Field Laboratory, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Ren
authors.initials: R
authors.lastname: Li
authors.affiliation: Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.
authors.forename: Zhenbang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Engineering and Materials Science Experiment Center, University of Science and Technology of China, Hefei, 230037, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
authors.affiliation: Engineering and Materials Science Experiment Center, University of Science and Technology of China, Hefei, 230037, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China. Electronic address: zhenguo@ustc.edu.cn.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Radiology Department of the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. Electronic address: whblqh@mail.ustc.edu.cn.
authors.forename: Haibao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, Department of Materials Science & Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, CAS High Magnetic Field Laboratory, University of Science and Technology of China, Hefei, 230026, China. Electronic address: cqw@ustc.edu.cn.
authors.forename: Qianwang
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D037621:Artemisinins / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D008279:Magnetic Resonance Imaging; D008807:Mice, Inbred BALB C; D064847:Multimodal Imaging; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D061848:Optical Imaging; D009942:Organometallic Compounds / Q000737:chemistry / Q000627:therapeutic use*; D010789:Phototherapy; D000068936:Theranostic Nanomedicine
chemical_list: D000970:Antineoplastic Agents; D037621:Artemisinins; D003692:Delayed-Action Preparations; D009942:Organometallic Compounds; C031327:artemisinin
keywords: Chemotherapy; Dual-MOFs; MRI/FOI dual-model imaging; Photothermal therapy; pH-responsive