title: Formulation and characterization of Turkish oregano microcapsules prepared by spray-drying technology.
abstract: The aim of this study was optimization of spray-drying process conditions for microencapsulation of Turkish oregano extract. Different concentrations of maltodextrin and gum arabic as encapsulating agents (wall material) as well as influence of selected processing variables were evaluated. The optimal conditions were maintained on the basis of the load of main bioactive compounds - ursolic, rosmarinic acids and carvacrol - in prepared microparticles after comparison of all significant response variables using desirability function. Physicomechanical properties of powders such as flowability, wettability, solubility, moisture content as well as product yield, encapsulation efficiency (EE), density, morphology and size distribution of prepared microparticles have been determined. The results demonstrated that the optimal conditions for spray-drying mixture consisted of two parts of wall material solution and one part of ethanolic oregano extract when the feed flow rate was 40 mL/min and air inlet temperature -170 °C. Optimal concentration of wall materials in solution was 20% while the ratio of maltodextrin and gum arabic was 8.74:1.26.
authors.affiliation: a Department of Drugs Technology and Social Pharmacy , Lithuanian University of Health Sciences, Medical Academy , Kaunas , Lithuania.
authors.forename: Juste
authors.initials: J
authors.lastname: Baranauskaite
authors.affiliation: b Department of Analytical and Toxicological Chemistry , Lithuanian University of Health Sciences, Medical Academy , Kaunas , Lithuania.
authors.forename: Liudas
authors.initials: L
authors.lastname: Ivanauskas
authors.affiliation: c Department of Pharmaceutics, Faculty of Pharmacy , University of Veterinary and Pharmaceutical Sciences , Brno , Czech Republic.
authors.forename: Ruta
authors.initials: R
authors.lastname: Masteikova
authors.affiliation: a Department of Drugs Technology and Social Pharmacy , Lithuanian University of Health Sciences, Medical Academy , Kaunas , Lithuania.
authors.forename: Dalia
authors.initials: D
authors.lastname: Kopustinskiene
authors.affiliation: a Department of Drugs Technology and Social Pharmacy , Lithuanian University of Health Sciences, Medical Academy , Kaunas , Lithuania.
authors.forename: Algirdas
authors.initials: A
authors.lastname: Baranauskas
authors.affiliation: a Department of Drugs Technology and Social Pharmacy , Lithuanian University of Health Sciences, Medical Academy , Kaunas , Lithuania.
authors.forename: Jurga
authors.initials: J
authors.lastname: Bernatoniene
mesh_terms: D002214:Capsules; D003890:Desiccation; D004339:Drug Compounding; D006170:Gum Arabic; D031341:Origanum
chemical_list: D002214:Capsules; D006170:Gum Arabic
keywords: Gum arabic; maltodextrin; microencapsulation; origanum onites; plant extract