title: [Effectiveness of Reamberin in orthopedic knee surgery].
abstract: OBJECTIVE
  To study an efficacy of Reamberine in complex therapy in early postoperative period after knee-joint surgery.
  
  
  METHODS
  It was analyzed treatment of 108 patients (47 men and 61 women) with degenerative diseases of knee-joint in postoperative period. Periarticular osteotomy of tibia and knee-joint replacement were performed. Patients were divided into 2 groups. Main group consisted of 43 patients who received Reamberine 400-800 ml with infusion rate 4-5 ml/min during 1-1,5 hours for 4-8 days postoperatively. Control group (65 patients) had conventional therapy with daily volume 400-800 ml.
  
  
  RESULTS
  It was revealed that Reamberine increased efficacy of postoperative treatment. There were earlier (by 52.6% compared with control group) improvement of health including weakness disappearance, sleep and appetite recovery. Hemodynamic parameters were also improved (stabilization of blood pressure and pulse). It was observed earlier disappearance of pain and edematous syndrome (by 32.3%). There were also earlier postoperative wound healing (by 21.3%) and reducing of rehabilitation terms (by 72%, i.e. 2.1 ± 0.7 vs. 7.5 ± 0.9 days respectively).
authors.affiliation: I.P.Pavlov First St.Petersburg State Medical University, Health Ministry of the Russian Federation, St.Petersburg.
authors.forename: Yu N
authors.initials: YN
authors.lastname: Orlov
mesh_terms: D000328:Adult; D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D010027:Osteotomy / Q000379:methods*; D019999:Pharmaceutical Solutions / Q000008:administration & dosage; D011184:Postoperative Period; D011859:Radiography / Q000379:methods; D020127:Recovery of Function / Q000187:drug effects*; D013386:Succinates / Q000008:administration & dosage*; D013977:Tibia / Q000000981:diagnostic imaging / Q000601:surgery; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D019999:Pharmaceutical Solutions; C549374:Reamberin; D013386:Succinates; D008536:Meglumine