title: Impact of the PROVAUR stewardship programme on linezolid resistance in a tertiary university hospital: a before-and-after interventional study.
abstract: There is little evidence of the impact of antimicrobial stewardship programmes on antimicrobial resistance.
  
  
  
  To study the efficacy and safety of a package of educational and interventional measures to optimize linezolid use and its impact on bacterial resistance.
  
  
  
  A quasi-experimental study was designed and carried out before and after implementation of a stewardship programme in hospitalized patients with Gram-positive infections treated with linezolid.
  
  
  
  The intervention reduced linezolid consumption by 76%. The risk of linezolid-resistant CoNS isolates (OR = 0.37; 95% CI = 0.27-0.49; P < 0.001) and Enterococcus faecalis (OR = 0.44; 95% CI = 0.21-0.90; P = 0.03) during the intervention period was lower than in the pre-intervention period.
  
  
  
  A programme to optimize linezolid use can contribute to reducing the resistance rate of CoNS and E. faecalis to this antibiotic.
authors.affiliation: Pharmacy Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain.
authors.forename: Lucrecia
authors.initials: L
authors.lastname: García-Martínez
authors.affiliation: Microbiology Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Gracia-Ahulfinger
authors.affiliation: Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain Infectious Diseases Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Machuca
authors.affiliation: Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain Infectious Diseases Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Cantisán
authors.affiliation: Pharmacy Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain.
authors.forename: Soraya
authors.initials: S
authors.lastname: De La Fuente
authors.affiliation: Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain Infectious Diseases Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain.
authors.forename: Clara
authors.initials: C
authors.lastname: Natera
authors.affiliation: Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain Infectious Diseases Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Pérez-Nadales
authors.affiliation: Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain Infectious Diseases Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain.
authors.forename: Elisa
authors.initials: E
authors.lastname: Vidal
authors.affiliation: Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain Infectious Diseases Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Rivero
authors.affiliation: Microbiology Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Rodríguez-Lopez
authors.affiliation: Pharmacy Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain.
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Del Prado
authors.affiliation: Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain Infectious Diseases Unit, Hospital Universitario Reina Sofía-IMIBIC-Universidad de Córdoba, Córdoba, Spain julian.torre.sspa@juntadeandalucia.es.
authors.forename: Julián
authors.initials: J
authors.lastname: Torre-Cisneros
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001291:Attitude of Health Personnel; D001521:Behavior Therapy; D024881:Drug Resistance, Bacterial; D004363:Drug Utilization / Q000592:standards*; D004502:Education, Medical, Continuing / Q000379:methods; D013293:Enterococcus faecalis / Q000187:drug effects / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006291:Health Policy; D006785:Hospitals, University; D006801:Humans; D000069349:Linezolid / Q000494:pharmacology / Q000627:therapeutic use*; D065228:Non-Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D013210:Staphylococcus / Q000187:drug effects / Q000302:isolation & purification; D011795:Surveys and Questionnaires; D062606:Tertiary Care Centers
chemical_list: D000900:Anti-Bacterial Agents; D000069349:Linezolid