title: Evaluation of proinflammatory cytokine and neopterin levels in women with papillary thyroid carcinoma.
abstract: BACKGROUND
  Papillary thyroid cancer is a disease that has been associated with chronic inflammation. The purpose of this study is to measure the production of the proinflammatory cytokines IL-1β, IL-6 and IL-8 and neopterin, which is a novel biomarker for cellular immune response in papillary thyroid cancer.
  
  
  METHODS
  The serum IL-1β, IL-6, IL-8 and neopterin values of 31 papillary thyroid cancer patients undergoing bilateral total thyroidectomy were measured before and 20 days after surgery. The values were compared with those of 39 healthy controls.
  
  
  RESULTS
  Serum IL-1β levels were similar across groups. IL-6 (p&lt;0.001), IL-8 (p = 0.015) and neopterin levels (p = 0.002) were higher in presurgical samples and returned to normal following surgery.
  
  
  CONCLUSIONS
  The proinflammatory cytokines IL-6 and IL-8, but not IL-1β, were produced in greater amounts in papillary thyroid cancer. Serum neopterin seems to be a valid biological marker supporting the presence of papillary thyroid cancer.
authors.affiliation: Department of General Surgery, Ankara Oncology Hospital, Ankara - Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Beksac
authors.affiliation: Department of Biochemistry, Ankara Oncology Hospital, Ankara - Turkey.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Sonmez
authors.affiliation: Department of General Surgery, Ankara Oncology Hospital, Ankara - Turkey.
authors.forename: Bahadir
authors.initials: B
authors.lastname: Cetin
authors.affiliation: Department of Biochemistry, Ankara University Faculty of Veterinary Medicine, Ankara - Turkey.
authors.forename: Gorkem
authors.initials: G
authors.lastname: Kismali
authors.affiliation: Department of Biochemistry, Ankara University Faculty of Veterinary Medicine, Ankara - Turkey.
authors.forename: Tevhide
authors.initials: T
authors.lastname: Sel
authors.affiliation: Department of General Surgery, Ankara Oncology Hospital, Ankara - Turkey.
authors.forename: Yildirim
authors.initials: Y
authors.lastname: Tuncer
authors.affiliation: Department of Biochemistry, Celal Bayar University, Manisa - Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Kosova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000097:blood* / Q000276:immunology / Q000473:pathology; D002291:Carcinoma, Papillary; D016022:Case-Control Studies; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000276:immunology / Q000473:pathology; D007378:Interleukins / Q000097:blood* / Q000276:immunology; D008875:Middle Aged; D019798:Neopterin / Q000097:blood* / Q000276:immunology; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000097:blood* / Q000276:immunology / Q000473:pathology; D055815:Young Adult
chemical_list: D007378:Interleukins; D019798:Neopterin