title: Phospholipid End-Capped Acid-Degradable Polyurethane Micelles for Intracellular Delivery of Cancer Therapeutics.
abstract: Nanoscale drug carriers fabricated by phospholipid end-capped polyurethane bearing acetal backbones that degrade in acidic conditions are fabricated. These micelles effectively allow drugs to enter the blood circulation, and then disintegrate in acidic endosomes and lysosomes for intelligent delivery of payloads.
authors.affiliation: BK21 PLUS Center for Advanced Chemical Technology, Department of Polymer Science and Engineering, Pusan National University, Busan, 609-735, Republic of Korea.
authors.forename: Johnson V
authors.initials: JV
authors.lastname: John
authors.affiliation: Department of Radiology, Hwasun Hospital, Chonnam National University, Hwasun, 519-763, Republic of Korea.
authors.forename: Reju George
authors.initials: RG
authors.lastname: Thomas
authors.affiliation: BK21 PLUS Center for Advanced Chemical Technology, Department of Polymer Science and Engineering, Pusan National University, Busan, 609-735, Republic of Korea.
authors.forename: Hye Ri
authors.initials: HR
authors.lastname: Lee
authors.affiliation: Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, 63737, Singapore.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Radiology, Hwasun Hospital, Chonnam National University, Hwasun, 519-763, Republic of Korea.
authors.forename: Yong Yeon
authors.initials: YY
authors.lastname: Jeong
authors.affiliation: BK21 PLUS Center for Advanced Chemical Technology, Department of Polymer Science and Engineering, Pusan National University, Busan, 609-735, Republic of Korea.
authors.forename: Il
authors.initials: I
authors.lastname: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008247:Lysosomes / Q000378:metabolism*; D008823:Micelles; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D010743:Phospholipids / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011140:Polyurethanes / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D008823:Micelles; D010743:Phospholipids; D011140:Polyurethanes
keywords: bioconjugation; drug delivery; micelles; phospholipids; polyurethanes