title: Identifying genetic loci affecting antidepressant drug response in depression using drug-gene interaction models.
abstract: Antidepressants are often only moderately successful in decreasing the severity of depressive symptoms. In part, antidepressant treatment response in patients with depression is genetically determined. However, although a large number of studies have been conducted aiming to identify genetic variants associated with antidepressant drug response in depression, only a few variants have been repeatedly identified. Within the present review, we will discuss the methodological challenges and limitations of the studies that have been conducted on this topic to date (e.g., 'treated-only design', statistical power) and we will discuss how specifically drug-gene interaction models can be used to be better able to identify genetic variants associated with antidepressant drug response in depression.
authors.affiliation: Department of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.|Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Raymond
authors.initials: R
authors.lastname: Noordam
authors.affiliation: Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.
authors.forename: Christy L
authors.initials: CL
authors.lastname: Avery
authors.affiliation: Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.|Apotheek Haagse Ziekenhuizen - HAGA, The Hague, The Netherlands.
authors.forename: Loes E
authors.initials: LE
authors.lastname: Visser
authors.affiliation: Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.|Inspectorate of Health Care, Utrecht, The Netherlands.
authors.forename: Bruno H
authors.initials: BH
authors.lastname: Stricker
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy* / Q000235:genetics*; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000235:genetics; D056426:Genetic Loci / Q000235:genetics*; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods*; D016032:Randomized Controlled Trials as Topic
chemical_list: D000928:Antidepressive Agents
keywords: antidepressive agents; drug–gene interaction models; pharmacogenomics