title: Physalis alkekengi and Alhagi maurorum ameliorate the side effect of cisplatin-induced nephrotoxicity.
abstract: Cisplatin is frequently being used for the treatment of different tumors, although the application of this agent is associated with nephrotoxicity. Here, we explored the antioxidant and anti-inflammatory activities of Physalis alkekengi and Alhagi maurorum; 400 mg kg(-1) per day P. alkekengi and 100 mg kg(-1) per day A. maurorum were administered in rats, orally for 10 days after a single dose of 7 mg kg(-1) intraperitoneal cisplatin. The concentrations of creatinine, urea-nitrogen, and relative and absolute excretion of sodium/potassium were evaluated before/after therapy. Levels of malondialdehyde (MDA) and ferric-reducing antioxidant power (FRAP) were measured to assess the oxidative stress induced by cisplatin. Moreover, tissues sections were used for histological analyses and evaluation of the degree of tissue damage. Cisplatin increased serum levels of creatinine and urea-nitrogen, relative/absolute excretion of sodium/potassium, and MDA, whereas decreased FRAP level. Interestingly, P. alkekengi or A. maurorum were able to reduce the level of the renal function markers as well as the levels of sodium/potassium. This effect was more pronounced by P. alkekengi. Moreover, cisplatin induced pathological damage in kidney, whereas treatment with these agents improved this condition. Our findings demonstrate the potential therapeutic impact of P. alkekengi and A. maurorum for improving cisplatin-induced nephrotoxicity, supporting further investigations on the novel potential clinical application of these agents for patients being treated with cisplatin to ameliorate cisplatin-induced nephrotoxicity.
authors.affiliation: Department of Physiology, Arak University of Medical Sciences, Arak, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Changizi-Ashtiyani
authors.affiliation: Student Research Committee, Arak University of Medical Sciences, Arak, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Alizadeh
authors.affiliation: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Najafi
authors.affiliation: Department of Histology, Arak University of Medical Sciences, Arak, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Babaei
authors.affiliation: Student Research Committee, Arak University of Medical Sciences, Arak, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Khazaei
authors.affiliation: Student Research Committee, Arak University of Medical Sciences, Arak, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Jafari
authors.affiliation: Department of Medicinal Plants, University of Arak, Arak, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Hossaini
authors.affiliation: Molecular Medicine Group, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Avan
authors.affiliation: Division of Nephrology, School of Medicine, Saint Louis University, Saint Louis, MO, USA.
authors.forename: B
authors.initials: B
authors.lastname: Bastani
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D000975:Antioxidants / Q000008:administration & dosage*; D002945:Cisplatin / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D007887:Fabaceae / Q000737:chemistry; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D032321:Physalis / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage*; D017207:Rats, Sprague-Dawley; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D010936:Plant Extracts; D002945:Cisplatin