title: DNA Triplexes-Guided Assembly of G-Quadruplexes for Constructing Label-free Fluorescent Logic Gates.
abstract: Assembly of G-quadruplexes guided by DNA triplexes in a controlled manner is achieved for the first time. The folding of triplex sequences in acidic conditions brings two separated guanine-rich sequences together and subsequently a G-quadruplex structure is formed in the presence of K(+) . Based on this novel platform, label-free fluorescent logic gates, such as AND, INHIBIT, and NOR, are constructed with ions as input and the fluorescence of a G-quadruplex-specific fluorescent probe NMM as output.
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Lijun
authors.identifier: http://orcid.org/0000-0002-7256-6324
authors.initials: L
authors.lastname: Xu
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Shanni
authors.initials: S
authors.lastname: Hong
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.|School of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, China.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Shen
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.
authors.forename: Jine
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, China. zhangjy@zzu.edu.cn.
authors.forename: Jianye
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China. rjpei2011@sinano.ac.cn.
authors.forename: Renjun
authors.initials: R
authors.lastname: Pei
mesh_terms: D001483:Base Sequence; D039301:Computers, Molecular; D004247:DNA / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D054856:G-Quadruplexes; D009690:Nucleic Acid Conformation; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; C051802:triplex DNA; D004247:DNA
keywords: DNA; G-quadruplexes; fluorescent probes; self-assembly; triplex DNA