title: Age is a significant predictor of early and late improvement in semen parameters after microsurgical varicocele repair.
abstract: Accumulating evidence indicates that varicocele repair improves sperm quality. However, longitudinal changes in sperm parameters and predictors of improved semen characteristics after surgery have not been fully investigated. We retrospectively reviewed data from 100 men who underwent microsurgical subinguinal varicocele repair at a single centre. Follow-up semen examinations were carried out at 3, 6 and 12 months post-operatively. Logistic regression was used to identify predictors of early (3 months) and late (≥6 months) improvement in semen parameters after varicocele repair. At 3 months post-operatively, 76.1% of the patients had improved total motile sperm counts, which continued to improve significantly up to 12 months post-operatively (p = .016). When comparing changes in semen parameters between younger (<37 years) and older (≥37 years) men, post-operative improvements in sperm concentration and motility were greater among younger men. Multivariate analysis showed that younger age was associated with early (p = .043) and late (p = .010) post-operative improvement in total motile sperm count. Our findings indicate that early varicocele repair improved semen parameters after surgery.
authors.affiliation: Department of Urology, Teikyo University, Itabashi, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kimura
authors.affiliation: Department of Urology, Toho University, Omori, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nagao
authors.affiliation: Department of Urology, Toho University, Omori, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tai
authors.affiliation: Department of Urology, Toho University, Omori, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.affiliation: Department of Urology, Toho University, Omori, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nakajima
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007248:Infertility, Male; D008297:Male; D008866:Microsurgery; D015999:Multivariate Analysis; D011247:Pregnancy; D012189:Retrospective Studies; D012661:Semen / Q000502:physiology*; D055101:Semen Analysis; D013085:Spermatic Cord / Q000098:blood supply; D014646:Varicocele / Q000601:surgery*; D014656:Vascular Surgical Procedures
keywords: male infertility; microsurgical varicocelectomy; semen parameters; varicocele; varicocele repair