title: Clindamycin-induced Kidney Diseases: A Retrospective Analysis of 50 Patients.
abstract: Objective There are many adverse reactions due to clindamycin, but kidney diseases (acute kidney injury, AKI) are uncommon. However, in recent years, the rate of clindamycin-induced kidney diseases has increased. We analyzed 50 patients with clindamycin-induced kidney diseases retrospectively, and investigated the characteristics of these kidney diseases in order to provide a reference for rational clinical drug use and to reduce drug-induced organ damage. Methods We investigated 50 patients diagnosed with clindamycin-induced kidney diseases retrospectively at the Department of Nephrology, Shandong University Qilu Hospital, from January 2009 to December 2013. The parameters included in our study were age, sex, clinical manifestations, efficacy and prognosis. Results All patients were diagnosed with clindamycin-induced kidney diseases within 48 hours of the application of clindamycin at 1.0-2.0 g/day. The patients included 29 women and 21 men. Most of the enrolled patients were 20-59 years old. Fifty-one patients were diagnosed with AKI stage 3 upon admission. Thirty-three had episodes of gross hematuria, but fever, skin rash and eosinophilia were rare. Urine analysis revealed mild proteinuria and severe tubular dysfunction. In the majority of patients, AKI was severe and required renal replacement therapy, but renal function in all patients had recovered significantly two months after discharge. Conclusion Clindamycin-induced AKI is largely reversible and is associated with episodes of gross hematuria. Clinicians should use clindamycin rationally and reduce the incidence of adverse reactions.
authors.affiliation: Department of Nephrology, Shandong University Qilu Hospital, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wan
authors.forename: Zhao
authors.initials: Z
authors.lastname: Hu
authors.forename: Jinhong
authors.initials: J
authors.lastname: Wang
authors.forename: Shimei
authors.initials: S
authors.lastname: Zhang
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Yang
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D002981:Clindamycin / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006417:Hematuria / Q000139:chemically induced; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D017582:Renal Replacement Therapy; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D002981:Clindamycin