title: Statin-treated patients with aneurysmal subarachnoid haemorrhage: a meta-analysis.
abstract: The cerebral vasospasm, delayed ischemic neurological deficit (DIND), mortality and poor neurological outcome induced by aneurysmal subarachnoid haemorrhage (SAH) remain the major causes of morbidity and mortality in aneurysmal SAH patients. The effects of statin-treated for aneurysmal SAH patients were not comprehensively assessed.
  
  
  
  A systematically literature search was conducted in PubMed, EMBASE, ScienceDirect and Web of Science to identify relevant studies update to March 2015. Data were extracted and appraised independently by two authors. Moreover, fixed or random effects models were applied to calculate pooled results based on the degree of heterogeneity.
  
  
  
  Nine RCTs and three observational studies with a total of 1957 patients met the inclusion criteria. The results showed that statin treatment was not associated with a decrease in the occurrence of DIND (RR: 0.81, 95% CI: 0.66-1.00, p = 0.05), mortality (RR: 0.90, 95% CI: 0.69-1.18, p = 0.46) and poor neurological outcome (RR: 1.02, 95% CI: 0.86-1.20, p = 0.84), nonetheless, had a potential effect on reducing the incidence of vasospasm (RR: 0.77, 95% CI: 0.66-0.89, p = 0.0006).
  
  
  
  This meta-analysis indicated that the use of statins decreases the occurrence of cerebral vasospasm, whereas did not support a beneficial effect of statins on the occurrence of DIND, death or poor neurological outcomes in patients with aneurysmal SAH.
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. lilixin2@hotmail.com.
authors.forename: R-L
authors.initials: RL
authors.lastname: Zhu
authors.forename: Z-J
authors.initials: ZJ
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: X-C
authors.initials: XC
authors.lastname: Lu
authors.forename: L-J
authors.initials: LJ
authors.lastname: Tang
authors.forename: B-S
authors.initials: BS
authors.lastname: Huang
authors.forename: W
authors.initials: W
authors.lastname: Yu
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: T-D
authors.initials: TD
authors.lastname: Qian
authors.forename: L-X
authors.initials: LX
authors.lastname: Li
mesh_terms: D000783:Aneurysm / Q000150:complications; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D020301:Vasospasm, Intracranial / Q000188:drug therapy
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors