title: [The effects of sacral nerve root electrostimulation on the colon function and its mechanisms in a rat model of spinal cord injury].
abstract: OBJECTIVE
  To study the effects of sacral nerve root electrostimulation (SNS) on the colon function and its mechanisms in rats with spinal cord injury (SCI).
  
  
  METHODS
  One hundred and four Wistar rats were divided into three groups: A, B and C. A group ( n = 24) was divided into three subgroups (n = 8) for studying the bioelectricity: Normal group (NG), SCI group (SCI) and SCI group with SNS(SNS); B group( n = 24) was divided into three subgroups( n = 8) for studying the colon motility: NG, SCI and SNS. C group( n = 56) were divided into three groups for studying the change of morphology and neurotransmitters(SP and VIP): NG (n = 8), SCI (n = 24), and SNS (n = 24) . In SCI and SNS, included of three subgroups: 24, 48, 72 h after spinal cord injury (n = 8).
  
  
  RESULTS
  In SCI group, the activity of bioelectricity in proximal and distal colon was reduced; the colon motility was lessened, and colon mucosa appeared different degree of damage; cell-cell connections between intestinal epithelial cells were destroyed. The expressions of substance P(SP) and vasoactive intestinal peptide (VIP) in colon were decreased obviously. SNS was found to activate the bioelectricity, promote the colon motility, improve the intestinal mucosal, and increase the expressions of SP and VIP. Conclusion: SNS can activate the peristalsis, rehabilitate the motility of denervated colon, protection of the intestinal mechanical barrier between intestinal epithelial cells and tight junction, rebuild the colon function through activating the bioelectricity and increase the expressions of SP and VIP.
authors.forename: Chun-hong
authors.initials: CH
authors.lastname: Bai
authors.forename: Xin-long
authors.initials: XL
authors.lastname: Ma
mesh_terms: D000818:Animals; D003106:Colon / Q000503:physiopathology*; D004599:Electric Stimulation Therapy; D004847:Epithelial Cells / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects; D008161:Lumbosacral Region / Q000294:innervation*; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013119:Spinal Cord Injuries / Q000628:therapy*; D013373:Substance P / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
chemical_list: D018377:Neurotransmitter Agents; D013373:Substance P; D014660:Vasoactive Intestinal Peptide