title: Effects of Sesaminol Feeding on Brain Aβ Accumulation in a Senescence-Accelerated Mouse-Prone 8.
abstract: Alzheimer's disease (AD) is characterized by the progressive accumulation of extracellular β-amyloid (Aβ) aggregates. Recently, the senescence-accelerated mouse-prone 8 (SAMP8) model was highlighted as a useful model of age-related AD. Therefore, we used the SAMP8 mouse to investigate the preventive effects of sesame lignans on the onset of AD-like pathology. In preliminary in vitro studies, sesaminol showed the greatest inhibitory effect on Aβ oligomerization and fibril formation relative to sesamin, sesamolin, and sesaminol triglucoside. Hence, sesaminol was selected for further evaluation in vivo. In SAMP8 mice, feed-through sesaminol (0.05%, w/w, in standard chow) administered over a 16 week period reduced brain Aβ accumulation and decreased serum 8-hydroxydeoxyguanosine, an indicator of oxidative stress. Furthermore, sesaminol administration increased the gene and protein expression of ADAM10, which is a protease centrally involved in the non-amyloidogenic processing of amyloid precursor protein. Taken together, these data suggest that long-term consumption of sesaminol may inhibit the accumulation of pathogenic Aβ in the brain.
authors.affiliation: Department of Bioscience and Biotechnology, Shinshu University , 8304 Minamiminowa, Kamiina, Nagano 399-4598, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Katayama
authors.affiliation: Department of Bioscience and Biotechnology, Shinshu University , 8304 Minamiminowa, Kamiina, Nagano 399-4598, Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Sugiyama
authors.affiliation: Department of Bioscience and Biotechnology, Shinshu University , 8304 Minamiminowa, Kamiina, Nagano 399-4598, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Kushimoto
authors.affiliation: Takemoto Oil & Fat Company, Limited , 11 Hamacho, Gamagori, Aichi 443-0036, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Uchiyama
authors.affiliation: Takemoto Oil & Fat Company, Limited , 11 Hamacho, Gamagori, Aichi 443-0036, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Hirano
authors.affiliation: Department of Bioscience and Biotechnology, Shinshu University , 8304 Minamiminowa, Kamiina, Nagano 399-4598, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000178:diet therapy* / Q000378:metabolism / Q000517:prevention & control; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004149:Dioxoles / Q000378:metabolism*; D004195:Disease Models, Animal; D005663:Furans / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D018384:Oxidative Stress; D012715:Sesame Oil / Q000378:metabolism*; D031685:Sesamum / Q000378:metabolism
chemical_list: D016564:Amyloid beta-Protein Precursor; D004149:Dioxoles; D005663:Furans; C066016:sesaminol; D012715:Sesame Oil
keywords: ADAM10; Aβ; SAMP8; brain; sesaminol