title: Topical, Biological and Clinical Challenges in the Management of Patients with Acne Vulgaris.
abstract: Acne vulgaris is one of the most common chronic inflammatory skin disorders among adolescents and young adults. It is associated with substantial morbidity and, rarely, with mortality. The exact worldwide incidence and prevalence are currently unknown. Current challenges involve improving understanding of the underlying pathophysiology of acne vulgaris and developing a practical treatment consensus. Expert panel discussions were held in 2013 and 2014 among a group of scientists and clinicians from the Omani and United Arab Emirate Dermatology Societies to ascertain the current optimal management of acne vulgaris, identify clinically relevant end-points and construct suitable methodology for future clinical trial designs. This article reviews the discussions of these sessions and recent literature on this topic.
authors.affiliation: Department of Dermatology, Rashid Hospital, Dubai, United Arab Emirates;
authors.forename: Anwar
authors.initials: A
authors.lastname: Al-Hammadi
authors.affiliation: Department of Dermatology, Al Nahdha Hospital, Muscat, Oman;
authors.forename: Abla
authors.initials: A
authors.lastname: Al-Ismaily
authors.affiliation: Department of Dermatology, Abu Dhabi Dermatology Clinic, Abu Dhabi, United Arab Emirates;
authors.forename: Sameer
authors.initials: S
authors.lastname: Al-Ali
authors.affiliation: Department of Clinical & Medical Affairs, Glenmark Pharmaceuticals Private Ltd., Mumbai, India;
authors.forename: Rajesh
authors.initials: R
authors.lastname: Ramadurai
authors.affiliation: Department of Clinical & Medical Affairs, Glenmark Pharmaceuticals Private Ltd., Mumbai, India;
authors.forename: Rishi
authors.initials: R
authors.lastname: Jain
authors.affiliation: Department of Dermatology, George Washington University Hospital, Washington D.C., USA;
authors.forename: Lynn
authors.initials: L
authors.lastname: McKinley-Grant
authors.affiliation: Department of Hematology & Oncology, Tufts University Medical Center, Boston, Massachusetts, USA.
authors.forename: Tariq I
authors.initials: TI
authors.lastname: Mughal
keywords: Acne Vulgaris; Antibiotics; Benzoyl Peroxide; Diagnosis; Isotretinoin; Molecular Biology; Retinoids; Therapeutics