title: Cardiac Function and Diastolic Dysfunction in Behcet's Disease: A Systematic Review and Meta-Analysis.
abstract: Background. Cardiovascular involvement in Behcet's disease (BD) is reported and has variable manifestations. It is not clear if diastolic dysfunction (DD) is increased in BD. Our objective was to evaluate the existing literature to determine if cardiac dysfunction, particularly DD, was more prevalent in these patients. Methods. A systematic review and meta-analysis of the available studies analyzing the echocardiographic findings in BD was conducted using a random-effects model. Mean differences were used to calculate the effect sizes of the echocardiographic parameters of interest. Results. A total of 22 studies with 1624 subjects were included in the analysis. Patients with BD had statistically significantly larger mean left atrial dimension (0.08, p = 0.0008), greater aortic diameter (0.16, p = 0.02), significantly reduced ejection fraction (-1.08, p < 0.0001), significantly prolonged mitral deceleration time (14.20, p < 0.0001), lower E/A ratio (-0.24, p = 0.05), and increased isovolumetric relaxation time (7.29, p < 0.00001). Conclusion. DD is increased in patients with BD by the presence of several echocardiographic parameters favoring DD as compared to controls. The meta-analysis also identified that LA dimension is increased in BD patients. EF has also been found to be lower in BD patients. Aortic diameter was also increased in BD patients as compared to controls.
authors.affiliation: Division of Rheumatology, Mayo Clinic Health System, Eau Claire, WI 54703, USA.
authors.forename: Fawad
authors.initials: F
authors.lastname: Aslam
authors.affiliation: Department of Cardiology, Texas Heart Institute at CHI St. Luke's Medical Center, Houston, TX 77030, USA.
authors.forename: Salman J
authors.initials: SJ
authors.lastname: Bandeali
authors.affiliation: Division of Biomedical Statistics and Informatics, Department of Health Sciences Research and Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55906, USA.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Crowson
authors.affiliation: Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Mahboob
authors.initials: M
authors.lastname: Alam