title: BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens.
abstract: Recent evidence implicates epigenetic mechanisms in drug-associated memory processes. However, a possible role for one major epigenetic mechanism, nucleosome remodelling, in drug-associated memories remains largely unexplored. Here we examine mice with genetic manipulations targeting a neuron-specific nucleosome remodelling complex subunit, BAF53b. These mice display deficits in cocaine-associated memory that are more severe in BAF53b transgenic mice compared with BAF53b heterozygous mice. Similar to the memory deficits, theta-induced long-term potentiation (theta-LTP) in the nucleus accumbens (NAc) is significantly impaired in slices taken from BAF53b transgenic mice but not heterozygous mice. Further experiments indicate that theta-LTP in the NAc is dependent on TrkB receptor activation, and that BDNF rescues theta-LTP and cocaine-associated memory deficits in BAF53b transgenic mice. Together, these results suggest a role for BAF53b in NAc neuronal function required for cocaine-associated memories, and also that BDNF/TrkB activation in the NAc may overcome memory and plasticity deficits linked to BAF53b mutations.
authors.affiliation: 301 Qureshey Research Lab, Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA.|Center for the Neurobiology of Learning and Memory, Irvine, California 92697, USA.|Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, California 92697, USA.
authors.forename: André O
authors.initials: AO
authors.lastname: White
authors.affiliation: 301 Qureshey Research Lab, Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA.|Center for the Neurobiology of Learning and Memory, Irvine, California 92697, USA.|Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, California 92697, USA.
authors.forename: Enikö A
authors.initials: EA
authors.lastname: Kramár
authors.affiliation: 301 Qureshey Research Lab, Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA.|Center for the Neurobiology of Learning and Memory, Irvine, California 92697, USA.|Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, California 92697, USA.
authors.forename: Alberto J
authors.initials: AJ
authors.lastname: López
authors.affiliation: 301 Qureshey Research Lab, Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA.|Center for the Neurobiology of Learning and Memory, Irvine, California 92697, USA.|Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, California 92697, USA.|Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697, USA.
authors.forename: Janine L
authors.initials: JL
authors.lastname: Kwapis
authors.affiliation: 301 Qureshey Research Lab, Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA.|Center for the Neurobiology of Learning and Memory, Irvine, California 92697, USA.|Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, California 92697, USA.
authors.forename: John
authors.initials: J
authors.lastname: Doan
authors.affiliation: 301 Qureshey Research Lab, Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA.|Center for the Neurobiology of Learning and Memory, Irvine, California 92697, USA.|Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, California 92697, USA.
authors.forename: David
authors.initials: D
authors.lastname: Saldana
authors.affiliation: Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: M Felicia
authors.initials: MF
authors.lastname: Davatolhagh
authors.affiliation: 301 Qureshey Research Lab, Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA.|Center for the Neurobiology of Learning and Memory, Irvine, California 92697, USA.|Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, California 92697, USA.
authors.forename: Yasaman
authors.initials: Y
authors.lastname: Alaghband
authors.affiliation: 301 Qureshey Research Lab, Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA.|Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697, USA.|Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, California 92697, USA.
authors.forename: Mathew
authors.initials: M
authors.lastname: Blurton-Jones
authors.affiliation: 301 Qureshey Research Lab, Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA.|Center for the Neurobiology of Learning and Memory, Irvine, California 92697, USA.|Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, California 92697, USA.
authors.forename: Dina P
authors.initials: DP
authors.lastname: Matheos
authors.affiliation: 301 Qureshey Research Lab, Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA.|Center for the Neurobiology of Learning and Memory, Irvine, California 92697, USA.|Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, California 92697, USA.|Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697, USA.
authors.forename: Marcelo A
authors.initials: MA
authors.lastname: Wood
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D002460:Cell Line; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism*; D003042:Cocaine; D019970:Cocaine-Related Disorders / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D017774:Long-Term Potentiation / Q000502:physiology; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009714:Nucleus Accumbens / Q000378:metabolism* / Q000503:physiopathology; D020813:Receptor, trkB / Q000378:metabolism
chemical_list: C469944:Actl6b protein, mouse; D019208:Brain-Derived Neurotrophic Factor; D002868:Chromosomal Proteins, Non-Histone; D020813:Receptor, trkB; D003042:Cocaine