title: Biomaterials for Enhancing CNS Repair.
abstract: The health of the central nervous system (CNS) does not only rely on the state of the neural cells but also on how various extracellular components organize cellular behaviors into proper tissue functions. Biomaterials have been valuable in restoring or augmenting the roles of extracellular components in the CNS in the event of injury and disease. In this review, we highlight how biomaterials have been enabling tools in important therapeutic strategies involving cell transplantation and drug/protein delivery. We further discuss advances in biomaterial design and applications that can potentially be translated into the CNS to provide unprecedented benefits.
authors.affiliation: Institute of Bioengineering and Nanotechnology, Singapore, Singapore. tclim@ibn.a-star.edu.sg.
authors.forename: Teck Chuan
authors.initials: TC
authors.lastname: Lim
authors.affiliation: Tissue Engineering, VA Boston Healthcare System, Boston, MA, USA.|Department of Orthopedics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Myron
authors.initials: M
authors.lastname: Spector
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use*; D017690:Cell Transplantation / Q000379:methods*; D002490:Central Nervous System / Q000293:injuries; D002493:Central Nervous System Diseases / Q000628:therapy*; D016503:Drug Delivery Systems; D006801:Humans; D056747:Immunomodulation
chemical_list: D001672:Biocompatible Materials
keywords: Bioimaging; Cell transplantation; Drug and protein delivery; Endogenous cells and molecules; Glycomimetics; Hydrogels; Immunomodulation; Matrix architecture; Scaffolds; Temporal control