title: [Potential sources of phthalates and bisphenol A and their significance in the development of metabolic diseases].
abstract: Nowadays, there is increasing evidence showing that the development of the metabolic syndrome combining obesity, type 2 diabetes mellitus, arterial hypertension and dyslipidemia involves except of traditional risk factors (overnutrition, lack of physical activity, genetic predisposition) also the effect of environmental organic substances called organic pollutants or endocrine disruptors. These chemicals can be found in plastic covers, paints, flame retardants, exhaust gases, fertilizers as well as diverse daily utensils. Phthalates, used primarily as plasticizers, and bisphenol A, are among the most wide-spread members of this group.The aim of this article is to provide a basic overview of the relationship between phthalates and bisphenol A and the etiopathogenesis of the metabolic syndrome and to highlight their potential sources. According to the analysis of materials used for parenteral nutrition and urinary excretion of phthalate metabolites and bisphenol A in subjects on long-term parenteral nutrition we suppose that currently used medical materials are safe with respect to the exposure to both phthalates and bisphenol A and that home environment, especially cosmetic products, might constitute a more probable source of these substances.
authors.forename: Miloš
authors.initials: M
authors.lastname: Mráz
authors.forename: Štěpán
authors.initials: Š
authors.lastname: Svačina
authors.forename: Eva
authors.initials: E
authors.lastname: Kotrlíková
authors.forename: Roman
authors.initials: R
authors.lastname: Piecha
authors.forename: Karel
authors.initials: K
authors.lastname: Vrbík
authors.forename: Jana
authors.initials: J
authors.lastname: Pavloušková
authors.forename: Zdeňka
authors.initials: Z
authors.lastname: Lacinová
authors.forename: Adam
authors.initials: A
authors.lastname: Vavrouš
authors.forename: Dana
authors.initials: D
authors.lastname: Müllerová
authors.forename: Dagmar
authors.initials: D
authors.lastname: Matějková
authors.forename: Jarmila
authors.initials: J
authors.lastname: Křížová
mesh_terms: D001559:Benzhydryl Compounds / Q000009:adverse effects*; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000503:physiopathology; D052244:Endocrine Disruptors / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects*; D044882:Glucose Metabolism Disorders / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000503:physiopathology; D009765:Obesity / Q000139:chemically induced / Q000503:physiopathology; D010636:Phenols / Q000009:adverse effects*; D010795:Phthalic Acids / Q000009:adverse effects*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D010636:Phenols; D010795:Phthalic Acids; C032279:phthalic acid; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: bisphenol A; endocrine disruptors; obesity; phthalates; type 2 diabetes mellitus.