title: Significance of monoclonal antibody SC3A expression in gastric carcinoma and precancerous lesion.
abstract: OBJECTIVE
  To study the significance of monoclonal antibody SC3A expression in gastric carcinoma and precancerous lesions.
  
  
  METHODS
  Immunohistochemical staining and mucin histochemical staining were performed on paraffin-embedded sections from gastric benign and malignant lesions from 101 patients.
  
  
  RESULTS
  SC3A positive rate was 80.3% (57/71) in lesions of gastric carcinoma. The expression of SC3A was not related to the classification, differentiation, metastasis and or survival rates. The positive rate of SC3A in cancers secreting acid mucin (90.2%) or sulphomucin (91.3%) was higher than that in cancers without acid mucin (20.0%) or sulphomucin (60.0%) (P < 0.01). The positive rate of sulphomucin was higher in cases of intestinal metaplasia with cancer (88.9%) than that of cases of intestinal metaplasia with a benign lesion (35.3%) (P < 0.01). Additionally, the positive rate of SC3A with sulphomucin in intestinal metaplasia (60.9%) was higher than that without sulphomucin (31.3%) (P < 0.05).
  
  
  CONCLUSIONS
  SC3A monoclonal antibody might be helpful in the diagnosis of gastric cancer and the discernment of histogenesis.
authors.affiliation: Ji-Feng Wu, Yu-Lin Song, Guang-Lin Yang, Yu-Ming Dong, Dao-Bing Wang, Min-Pei Liu, Department of Pathology, Anhui Medical University, Hefei 230032, Anhui Province, China.
authors.forename: J F
authors.initials: JF
authors.lastname: Wu
authors.affiliation: Ji-Feng Wu, Yu-Lin Song, Guang-Lin Yang, Yu-Ming Dong, Dao-Bing Wang, Min-Pei Liu, Department of Pathology, Anhui Medical University, Hefei 230032, Anhui Province, China.
authors.forename: Y L
authors.initials: YL
authors.lastname: Song
authors.affiliation: Ji-Feng Wu, Yu-Lin Song, Guang-Lin Yang, Yu-Ming Dong, Dao-Bing Wang, Min-Pei Liu, Department of Pathology, Anhui Medical University, Hefei 230032, Anhui Province, China.
authors.forename: G L
authors.initials: GL
authors.lastname: Yang
authors.affiliation: Ji-Feng Wu, Yu-Lin Song, Guang-Lin Yang, Yu-Ming Dong, Dao-Bing Wang, Min-Pei Liu, Department of Pathology, Anhui Medical University, Hefei 230032, Anhui Province, China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Dong
authors.affiliation: Ji-Feng Wu, Yu-Lin Song, Guang-Lin Yang, Yu-Ming Dong, Dao-Bing Wang, Min-Pei Liu, Department of Pathology, Anhui Medical University, Hefei 230032, Anhui Province, China.
authors.forename: D B
authors.initials: DB
authors.lastname: Wang
authors.affiliation: Ji-Feng Wu, Yu-Lin Song, Guang-Lin Yang, Yu-Ming Dong, Dao-Bing Wang, Min-Pei Liu, Department of Pathology, Anhui Medical University, Hefei 230032, Anhui Province, China.
authors.forename: M P
authors.initials: MP
authors.lastname: Liu
keywords: antibodies, monoclonal/metabolism; stomach neoplasms/immunology