title: Tolerance to the Intestinal Microbiota Mediated by ROR(γt)(+) Cells.
abstract: Harmless microbes colonizing the gut require the establishment of a well-equilibrated symbiosis between this microbiota and its host. However, the immune system is primed to recognize both conserved microbial patterns and foreign antigens, and therefore developed strong tolerance mechanisms to prevent potential fatal immune reactivity to symbiotic microbes. The transcription factor RAR-related orphan-like γt [ROR(γt); encoded by Rorc] plays a key role in the gut for lymphoid tissue organogenesis, development of innate lymphoid cells type 3 (ILC3s) and proinflammatory type 17 T helper (Th17) cells. Surprisingly, recent research has revealed a contribution of ROR(γt)-expressing cells in a variety of tolerance mechanisms in both the innate and adaptive immune system.
authors.affiliation: Center of Allergy and Environment (ZAUM), Technische Universität and Helmholtz Center Munich, Biedersteiner Strasse 29, 80802 Munich, Germany. Electronic address: caspar.ohnmacht@helmholtz-muenchen.de.
authors.forename: Caspar
authors.initials: C
authors.lastname: Ohnmacht
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000069196:Gastrointestinal Microbiome; D006706:Homeostasis; D006801:Humans; D007108:Immune Tolerance; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000276:immunology* / Q000382:microbiology; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000378:metabolism*; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D013559:Symbiosis; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D051192:Receptors, Pattern Recognition
keywords: Immunological tolerance; RAR-related orphan receptor γt; microbiota; regulatory T cells