title: A comparative evaluation of antimicrobial coated versus nonantimicrobial coated peripherally inserted central catheters on associated outcomes: A randomized controlled trial.
abstract: Central line-associated bloodstream infections (CLABSIs) are a common life-threatening risk factor associated with central venous catheters (CVCs). Research has demonstrated benefit in reducing CLABSIs when CVCs coated with antimicrobials are inserted. The impact of chlorhexidine (CHG)-impregnated versus non-CHG peripherally inserted central catheters (PICCs) on risk of CLABSI is unknown. Venous thromboembolism (VTE) is also a complication associated with CVCs. This study compares the impact of both PICC lines on these outcomes.
  
  
  
  Patients in 3 high-risk units were randomly assigned to receive either a CHG-impregnated or non-CHG PICC line. Laboratory data were collected and reviewed daily on all study patients. The PICC dressing site was assessed daily. Medical record documentation was reviewed to determine presence of CLABSI or VTE.
  
  
  
  There were 167 patients who completed the study. Three patients developed CLABSI (2 in the CHG group, and 1 in the non-CHG group), and 3 patients developed VTE (2 in the non-CHG group, and 1 in the CHG group). No significant relationship was noted between the type of PICC line on development of a CLABSI (P = .61) or VTE (P > .99). A significant difference was noted in moderate bleeding (P ≤ .001) requiring thrombogenic dressing in the patients who had the CHG PICC line.
  
  
  
  No differences were noted in the development of CLABSI and VTE between the CHG and non-CHG groups.
authors.affiliation: Indiana University School of Nursing, Indianapolis, IN. Electronic address: sustorey@iu.edu.
authors.forename: Susan
authors.initials: S
authors.lastname: Storey
authors.affiliation: Vincent Hospital, Indianapolis, IN.
authors.forename: Jamie
authors.initials: J
authors.lastname: Brown
authors.affiliation: Vincent Hospital, Indianapolis, IN.
authors.forename: Angela
authors.initials: A
authors.lastname: Foley
authors.affiliation: Indiana University Hospital, Indianapolis, IN.
authors.forename: Erica
authors.initials: E
authors.lastname: Newkirk
authors.affiliation: Parkview Health System, Fort Wayne, IN.
authors.forename: Jan
authors.initials: J
authors.lastname: Powers
authors.affiliation: Vincent Hospital, Indianapolis, IN.
authors.forename: Julie
authors.initials: J
authors.lastname: Barger
authors.affiliation: Vincent Hospital, Indianapolis, IN.
authors.forename: Karen
authors.initials: K
authors.lastname: Paige
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D055499:Catheter-Related Infections / Q000453:epidemiology / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000379:methods*; D062905:Central Venous Catheters / Q000009:adverse effects*; D002710:Chlorhexidine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000453:epidemiology / Q000517:prevention & control*; D016896:Treatment Outcome; D054556:Venous Thromboembolism / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D000891:Anti-Infective Agents, Local; D002710:Chlorhexidine
keywords: Catheter line–associated bloodstream infection; chlorhexidine-impregnated peripherally inserted central catheter lines; patient outcomes; peripherally inserted central catheters; randomized controlled trial; venous thromboembolism