title: [Inflammation and bone : Osteoimmunological aspects].
abstract: Microscopic fractures (so-called microcracks) or traumatic macrofractures require bone, as the basic scaffold of the human body, to have a high regenerative capability. In order to be able to provide this regenerative capability, bone is in a constant process of remodeling. This finely tuned homeostasis of bone formation and degradation can become disrupted, which leads to osteoporosis or other bone disorders. It has been shown that the immune system is substantially involved in the regulation of bone homeostasis and that chronic inflammation in particular can disturb this balance; therefore, this article reviews the osteoimmunological aspects contributing to osteoporosis and other diseases associated with bone degradation.
authors.affiliation: Innere Medizin mit Schwerpunkt Rheumatologie, Kerckhoff-Klinik Bad Nauheim, Rheumatologie und Klin. Immunologie, Justus-Liebig-Universität Gießen, Benekestr. 2-8, 61231, Bad Nauheim, Deutschland. k.frommer@kerckhoff-klinik.de.
authors.forename: K W
authors.initials: KW
authors.lastname: Frommer
authors.affiliation: Innere Medizin mit Schwerpunkt Rheumatologie, Kerckhoff-Klinik Bad Nauheim, Rheumatologie und Klin. Immunologie, Justus-Liebig-Universität Gießen, Benekestr. 2-8, 61231, Bad Nauheim, Deutschland.
authors.forename: E
authors.initials: E
authors.lastname: Neumann
authors.affiliation: Innere Medizin mit Schwerpunkt Rheumatologie, Kerckhoff-Klinik Bad Nauheim, Rheumatologie und Klin. Immunologie, Justus-Liebig-Universität Gießen, Benekestr. 2-8, 61231, Bad Nauheim, Deutschland.
authors.forename: U
authors.initials: U
authors.lastname: Lange
mesh_terms: D001842:Bone and Bones / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D018448:Models, Immunological; D010000:Osteitis / Q000209:etiology / Q000276:immunology*; D010012:Osteogenesis / Q000276:immunology; D010024:Osteoporosis / Q000150:complications / Q000276:immunology*; D012216:Rheumatic Diseases / Q000209:etiology / Q000276:immunology*
chemical_list: D016207:Cytokines
keywords: Degeneration; Fractures; Homeostasis; Osteoporosis; Regeneration