title: AXIN2 Polymorphisms and Their Association with Colorectal Cancer in Mexican Patients.
abstract: OBJECTIVE
  The aim of this study was to investigate the association of the rs2240308 and rs1133683 polymorphisms in the AXIN2 gene with colorectal cancer (CRC) in Mexican patients.
  
  
  METHODS
  Genomic DNAs from 201 CRC patients and 100 healthy blood donors were analyzed for AXIN2 gene polymorphisms by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Statistical associations were calculated using the odds ratio (OR) test.
  
  
  RESULTS
  The genotype distribution of the rs1133683 polymorphism C > T showed a statistical difference between the two study groups (p = 0.0019). Moreover, OR analyses demonstrated that individuals with either the C/T or T/T genotype have a decreased risk for CRC compared with individuals with the C/C genotype (OR = 0.47, 95% confidence interval [CI] = 0.25-0.86, p = 0.0134 and OR = 0.24, 95% CI = 0.10-0.57, p = 0.005, respectively). This association was also evident in a stratified analysis based on tumor-node-metastasis (TNM) stage. For the rs2240308 polymorphism C > T, the OR analysis showed a significantly increased risk for carriers of the T/T genotype (OR = 2.64, 95% CI = 1.12-6.24, p = 0.0236) and this association was also evident in the stratified analysis by TNM stage.
  
  
  CONCLUSIONS
  Our results indicate the possibility that variations in the AXIN2 gene may play a significant role in promoting or preventing CRC development.
authors.affiliation: 1 División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS) , Guadalajara, México .
authors.forename: Mónica Alejandra
authors.initials: MA
authors.lastname: Rosales-Reynoso
authors.affiliation: 1 División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS) , Guadalajara, México .
authors.forename: Abril Renee
authors.initials: AR
authors.lastname: Arredondo-Valdez
authors.affiliation: 1 División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS) , Guadalajara, México .
authors.forename: Laura Ivonne
authors.initials: LI
authors.lastname: Wence-Chávez
authors.affiliation: 2 División de Genética, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS) , Guadalajara, México .
authors.forename: Patricio
authors.initials: P
authors.lastname: Barros-Núñez
authors.affiliation: 1 División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS) , Guadalajara, México .
authors.forename: Martha P
authors.initials: MP
authors.lastname: Gallegos-Arreola
authors.affiliation: 1 División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS) , Guadalajara, México .
authors.forename: Silvia Esperanza
authors.initials: SE
authors.lastname: Flores-Martínez
authors.affiliation: 1 División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS) , Guadalajara, México .
authors.forename: Jose
authors.initials: J
authors.lastname: Sánchez-Corona
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D000328:Adult; D000483:Alleles; D060466:Axin Protein / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: C491761:AXIN2 protein, human; D060466:Axin Protein