title: Electrophysiologist shows a cation channel function of MLKL.
abstract: Whether mixed lineage kinase domain-like (MLKL) mediates necroptosis by forming ion channel, none-selective pore, or simply by disrupting plasma membrane is unclear. In a paper published in recent issue of Cell Research, Xia et al. showed that MLKL functions as a novel class of cation channel.
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Jiahuai
authors.initials: J
authors.lastname: Han
mesh_terms: D017209:Apoptosis; D002412:Cations; D002462:Cell Membrane; D006801:Humans; D009336:Necrosis; D011494:Protein Kinases
chemical_list: D002412:Cations; C570693:MLKL protein, human; D011494:Protein Kinases