title: PAF is a potent pyrogen and cryogen in rodents, but it does not mediate thermoregulatory responses to bacterial endotoxin.
abstract: Concordance between lipopolysaccharide and platelet activating factor - mediated events have suggested that the latter likely mediates all effects induced by the former. In this issue of Temperature, Steiner and Romanovsky challenge this notion, showing that while platelet activating factor is a potent pyrogenic mediator, the thermoregulatory responses to lipopolysaccharide are instead induced by prostaglandins.
authors.affiliation: Department of Studies in Biochemistry; University of Mysore; Manasagangothri , Mysore, Karnataka, India.
authors.forename: Gopal K
authors.initials: GK
authors.lastname: Marathe
authors.affiliation: Department of Cellular and Molecular Medicine; Cleveland Clinic Lerner Research Institute; Cleveland , OH USA.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: McIntyre
keywords: LPS; PAF; PAF-R; PGE2; cyclooxygenase; endotoxin; febrile response; thermoregulation; vagotomy