title: Self-aggregating TIAF1 in lung cancer progression.
abstract: Recent studies have demonstrated that transforming growth factor beta (TGF-β1)-induced antiapoptotic factor (TIAF1) is able to form aggregates in the hippocampi of middle-aged normal individuals. The aggregating TIAF1 induces generation of amyloid beta (Aβ) for causing neurodegeneration. Intriguingly, TIAF1 aggregates are shown, together with Smad4 and Aβ, in the cancer stroma and peritumor capsules of many solid tumors. During lung cancer progression, for example, TIAF1 and amyloid fibrils are significantly upregulated in the cancer stroma. Aggregates of TIAF1 and Aβ are shown on the interface between metastatic lung cancer cells and the brain tissues. Conceivably, these peritumor materials are needed for cancer cells to survive. In vitro experiments revealed that TIAF1 is a crucial component for tumor suppressors p53 and WWOX-mediated tumor suppression and apoptosis. While metastatic lung cancer cells are frequently devoid of WWOX and p53, we provide new perspectives regarding the role of TIAF1 in the pathogenesis of lung cancer development, and propose a therapeutic approach for targeting TIAF1.
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, Peoples' Republic China.
authors.forename: Qunying
authors.initials: Q
authors.lastname: Hong
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University College of Medicine, Tainan, Taiwan.
authors.forename: Li-Jin
authors.initials: LJ
authors.lastname: Hsu
authors.affiliation: Institute of Molecular Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan.
authors.forename: Pei-Yi
authors.initials: PY
authors.lastname: Chou
authors.affiliation: Institute of Basic Medical Science, National Cheng Kung University College of Medicine, Tainan, Taiwan.
authors.forename: Ying-Tsen
authors.initials: YT
authors.lastname: Chou
authors.affiliation: Institute of Molecular Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan.
authors.forename: Chen-Yu
authors.initials: CY
authors.lastname: Lu
authors.affiliation: Institute of Molecular Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan.
authors.forename: Yu-An
authors.initials: YA
authors.lastname: Chen
authors.affiliation: Institute of Molecular Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan. nschang13827@gmail.com.|Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan, Taiwan. nschang13827@gmail.com.|Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, NY, USA. nschang13827@gmail.com.|Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA. nschang13827@gmail.com.
authors.forename: Nan-Shan
authors.initials: NS
authors.lastname: Chang
keywords: Lung cancer; Protein aggregation; TGF-β; TIAF1