title: A common polymorphism rs1800247 in osteocalcin gene is associated with hypertension and diastolic blood pressure levels: the Shanghai Changfeng study.
abstract: Osteocalcin may have a role in hypertension due to its close relationship with energy metabolism and insulin sensitivity. The aim of this study was to evaluate the association of a common polymorphism rs1800247 in osteocalcin gene with hypertension and related traits. This was a population-based cross-sectional study including 5647 individuals. Baseline information was collected. Body mass index (BMI), waist circumference, blood pressure, glucose and lipids were determined. Homeostasis model assessment for insulin resistance (HOMA-IR) was used to estimate insulin sensitivity. Genotyping was performed by matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy. The carriers of C allele of rs1800247 were associated with a decreased odds of hypertension compared with the carriers of T allele adjusted for age, sex and BMI (odds ratio (OR)=0.89, 95% confidence interval (CI) 0.81-0.97, P=0.01). The carriers of C allele were also associated with a lower diastolic blood pressure (DBP) level adjusted for age, sex and BMI in normotensive individuals (β=-0.55, 95% CI -0.99 to -0.10, P=0.02), but its association with systolic blood pressure levels was not significant. The interaction between rs1800247 and HOMA-IR on hypertension was significant (P<0.001). In the stratified analysis by the median of HOMA-IR (1.93), rs1800247 was significantly associated with hypertension in the subgroup with HOMA-IR⩽1.93 (OR=0.82, 95% CI 0.71-0.94, P=0.005), but this association was not significant in the subgroup with HOMA-IR >1.93. We demonstrated that a common polymorphism rs1800247 in osteocalcin gene was associated with hypertension and DBP levels. The association of rs1800247 with hypertension was affected by its interaction with HOMA-IR.
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Ling
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: X
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: H
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: H
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: B
authors.initials: B
authors.lastname: Pan
authors.affiliation: Department of Clinical Nutrition, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: J
authors.initials: J
authors.lastname: Gao
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000235:genetics*; D016009:Chi-Square Distribution; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D015675:Osteocalcin / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D019655:Quantitative Trait, Heritable; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D015675:Osteocalcin