title: Antiparasitic drugs: in vitro tests against nematophagous fungi.
abstract: The use of biological agents has been intensified in recent years against eggs and larvae of gastrointestinal nematodes as an alternative control method in pasture plant health management, with the concomitant use with antiparasitic drugs still occurring. The aim of this study was to test the in vitro activity of the following antiparasitic drugs: Ivermectin and albendazole against the following nematophagous fungi: Paecilomyces fumosoroseus, Paecilomyces lilacinus and Paecilomyces variotii. The agar diffusion test was performed using an initial concentration of 0.0016g/mL of each drug, after solidification of the culture medium containing the drug concentration each nematophagous fungi was inoculated. The results showed that in a concentration of 80μg/mL, the fungal growth decreased, however, with the concentration of 160μg/mL, there was no fungal growth in both drugs, compared to the control, which indicates an inhibition in the development of the nematophagous fungi studied when they come in contact with ivermectin and albendazole.
authors.affiliation: Microbiology and Parasitology Department, Institute of Biology, Universidade Federal de Pelotas - UFPel, Pelotas, RS, Brazil.
authors.forename: G F
authors.initials: GF
authors.lastname: Ferreira
authors.affiliation: Microbiology and Parasitology Department, Institute of Biology, Universidade Federal de Pelotas - UFPel, Pelotas, RS, Brazil.
authors.forename: T M
authors.initials: TM
authors.lastname: Freitas
authors.affiliation: Microbiology and Parasitology Department, Institute of Biology, Universidade Federal de Pelotas - UFPel, Pelotas, RS, Brazil.
authors.forename: C L
authors.initials: CL
authors.lastname: Gonçalves
authors.affiliation: Microbiology and Parasitology Department, Institute of Biology, Universidade Federal de Pelotas - UFPel, Pelotas, RS, Brazil.
authors.forename: J F
authors.initials: JF
authors.lastname: Mendes
authors.affiliation: Microbiology and Parasitology Department, Institute of Biology, Universidade Federal de Pelotas - UFPel, Pelotas, RS, Brazil.
authors.forename: J N
authors.initials: JN
authors.lastname: Vieira
authors.affiliation: Microbiology and Parasitology Department, Institute of Biology, Universidade Federal de Pelotas - UFPel, Pelotas, RS, Brazil.
authors.forename: J P
authors.initials: JP
authors.lastname: Villareal
authors.affiliation: Microbiology and Parasitology Department, Institute of Biology, Universidade Federal de Pelotas - UFPel, Pelotas, RS, Brazil.
authors.forename: P S
authors.initials: PS
authors.lastname: Nascente
mesh_terms: D015766:Albendazole / Q000494:pharmacology*; D000977:Antiparasitic Agents / Q000494:pharmacology*; D007559:Ivermectin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010143:Paecilomyces / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin; D015766:Albendazole