title: Demographic, Reproductive, and Dietary Determinants of Perfluorooctane Sulfonic (PFOS) and Perfluorooctanoic Acid (PFOA) Concentrations in Human Colostrum.
abstract: To determine demographic, reproductive, and maternal dietary factors that predict perfluoroalkyl substance (PFAS) concentrations in breast milk, we measured perfluorooctane sulfonic (PFOS) and perfluorooctanoic acid (PFOA) concentrations, using liquid chromatography-mass spectrometry, in 184 colostrum samples collected from women participating in a cohort study in Eastern Slovakia between 2002 and 2004. During their hospital delivery stay, mothers completed a food frequency questionnaire, and demographic and reproductive data were also collected. PFOS and PFOA predictors were identified by optimizing multiple linear regression models using Akaike's information criterion (AIC). The geometric mean concentration in colostrum was 35.3 pg/mL for PFOS and 32.8 pg/mL for PFOA. In multivariable models, parous women had 40% lower PFOS (95% CI: -56 to -17%) and 40% lower PFOA (95% CI: -54 to -23%) concentrations compared with nulliparous women. Moreover, fresh/frozen fish consumption, longer birth intervals, and Slovak ethnicity were associated with higher PFOS and PFOA concentrations in colostrum. These results will help guide the design of future epidemiologic studies examining milk PFAS concentrations in relation to health end points in children.
authors.affiliation: Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry , Rochester, New York 14642, United States.|Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry , Rochester, New York 14642, United States.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Jusko
authors.affiliation: Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry , Rochester, New York 14642, United States.
authors.forename: Marina
authors.initials: M
authors.lastname: Oktapodas
authors.affiliation: Department of Environmental Medicine, Slovak Medical University , Bratislava 833 03, Slovak Republic.
authors.forename: L'ubica
authors.initials: L
authors.lastname: Palkovičová Murinová
authors.affiliation: Institute of Physiology, Comenius University, Faculty of Medicine , Bratislava 814 99, Slovak Republic.
authors.forename: Katarina
authors.initials: K
authors.lastname: Babinská
authors.affiliation: Institute of Hygiene, Comenius University, Faculty of Medicine , Bratislava 814 99, Slovak Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Babjaková
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health and Université de Montréal Public Health Research Institute (IRSPUM), Université de Montréal , Montreal, Quebec H3C 3J7, Canada.
authors.forename: Marc-André
authors.initials: MA
authors.lastname: Verner
authors.affiliation: Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University , Greenville, North Carolina 27858, United States.
authors.forename: Jamie C
authors.initials: JC
authors.lastname: DeWitt
authors.affiliation: Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry , Rochester, New York 14642, United States.
authors.forename: Kelly
authors.initials: K
authors.lastname: Thevenet-Morrison
authors.affiliation: Department of Toxic Organic Pollutants, Slovak Medical University , Bratislava 833 03, Slovak Republic.
authors.forename: Kamil
authors.initials: K
authors.lastname: Čonka
authors.affiliation: Department of Toxic Organic Pollutants, Slovak Medical University , Bratislava 833 03, Slovak Republic.
authors.forename: Beata
authors.initials: B
authors.lastname: Drobná
authors.affiliation: Department of Toxic Organic Pollutants, Slovak Medical University , Bratislava 833 03, Slovak Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Chovancová
authors.affiliation: Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry , Rochester, New York 14642, United States.
authors.forename: Sally W
authors.initials: SW
authors.lastname: Thurston
authors.affiliation: Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry , Rochester, New York 14642, United States.
authors.forename: B Paige
authors.initials: BP
authors.lastname: Lawrence
authors.affiliation: Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry , Rochester, New York 14642, United States.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Dozier
authors.affiliation: Department of Pediatrics, University of Rochester School of Medicine and Dentistry , Rochester, New York 14642, United States.
authors.forename: Kirsi M
authors.initials: KM
authors.lastname: Järvinen
authors.affiliation: Department of Environmental Medicine, Slovak Medical University , Bratislava 833 03, Slovak Republic.
authors.forename: Henrieta
authors.initials: H
authors.lastname: Patayová
authors.affiliation: Department of Environmental Medicine, Slovak Medical University , Bratislava 833 03, Slovak Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Trnovec
authors.affiliation: Institute of Environment, Health and Societies, Brunel University London , Uxbridge UB8 3PH, United Kingdom.
authors.forename: Juliette
authors.initials: J
authors.lastname: Legler
authors.affiliation: Department of Public Health Sciences, Division of Environmental and Occupational Health, School of Medicine, UC Davis , Davis, California 95616, United States.
authors.forename: Irva
authors.initials: I
authors.lastname: Hertz-Picciotto
authors.affiliation: Institute of Environmental Studies, VU University , Amsterdam 1081 HV, The Netherlands.
authors.forename: Marja H
authors.initials: MH
authors.lastname: Lamoree
mesh_terms: D017738:Alkanesulfonic Acids; D000818:Animals; D002210:Caprylates; D002853:Chromatography, Liquid; D015331:Cohort Studies; D003126:Colostrum / Q000737:chemistry*; D003710:Demography; D005466:Fluorocarbons; D006801:Humans
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D005466:Fluorocarbons