title: Biocompatibility and nanostructured materials: applications in nanomedicine.
abstract: There has been huge interest in applications of nanomaterials in biomedical science, including diagnosis, drug delivery, and development of human organs. Number of these nanomaterials has been already studied in human or at pre-clinical trial. There is a growing concern on potential toxicity and adverse effects of nanomaterials on human health, including lack of standard method of assessment of toxicology of these materials. Our investigation indicated that the bare and small nanoparticle have higher toxicity than modified and bulk materials, respectively. In addition, spherical nanoparticles have less toxicity than rod nanoparticles due to immune response of body.
authors.affiliation: a Department of Medical Nanotechnology , School of Advanced Technologies in Medicine, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Adabi
authors.affiliation: b Department of Nanotechnology, Research and Clinical Center for Infertility , Shahid Sadoughi University of Medical Sciences , Yazd , Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Naghibzadeh
authors.affiliation: c Department of Metallurgy and Materials Engineering, Faculty of Engineering, Roudehen Branch , Islamic Azad University , Roudehen , Tehran , Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Adabi
authors.affiliation: a Department of Medical Nanotechnology , School of Advanced Technologies in Medicine, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Zarrinfard
authors.affiliation: a Department of Medical Nanotechnology , School of Advanced Technologies in Medicine, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Seyedeh Sara
authors.initials: SS
authors.lastname: Esnaashari
authors.affiliation: d Centre for Nanotechnology and Regenerative Medicine , University College London , London , United Kingdom.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Seifalian
authors.affiliation: a Department of Medical Nanotechnology , School of Advanced Technologies in Medicine, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Faridi-Majidi
authors.affiliation: e Department of Medical Biotechnology , School of Advanced Technologies in Medicine, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Hammed
authors.initials: H
authors.lastname: Tanimowo Aiyelabegan
authors.affiliation: a Department of Medical Nanotechnology , School of Advanced Technologies in Medicine, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Ghanbari
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry / Q000633:toxicity
chemical_list: D001672:Biocompatible Materials
keywords: Biocompatibility; blood brain barrier; immune response; nanomaterials; polymer; toxicity