title: [Benzodiazepine or non-benzodiazepine hypnotics withdrawal syndrome during hospitalization: A series of 22 cases].
abstract: Twenty-two cases related to benzodiazepine (BZD) withdrawal syndrome were identified and reported to Amiens's regional pharmacovigilance center between January 1st, 1995 and March 25th, 2014, all with a favourable outcome after reintroduction of a BZD. Despite being a very classical well-known side effect, physicians may underestimate this risk. Our series also confirms that the patient is misinformed about the consequences of an abrupt BZD discontinuation especially when the BZD has been consumed for many years. Interviewing patient and his family on the nature of the current medical treatments should be systematic and an early diagnostic step taken by physicians faced with a recent behavioral disorder. Moreover, this would prevent unnecessary, sometimes invasive, expensive investigations and a prolonged hospitalization.
authors.affiliation: Centre de biologie humaine, centre régional de pharmacovigilance de Picardie, centre hospitalier universitaire d'Amiens, 80054 Amiens cedex 1, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Thorel
authors.affiliation: Centre de biologie humaine, centre régional de pharmacovigilance de Picardie, centre hospitalier universitaire d'Amiens, 80054 Amiens cedex 1, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Fummi
authors.affiliation: Centre de biologie humaine, centre régional de pharmacovigilance de Picardie, centre hospitalier universitaire d'Amiens, 80054 Amiens cedex 1, France. Electronic address: gras.valerie@chu-amiens.fr.
authors.forename: Valérie
authors.initials: V
authors.lastname: Gras
authors.affiliation: Centre de biologie humaine, centre régional de pharmacovigilance de Picardie, centre hospitalier universitaire d'Amiens, 80054 Amiens cedex 1, France.
authors.forename: Kamel
authors.initials: K
authors.lastname: Masmoudi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001569:Benzodiazepines / Q000008:administration & dosage / Q000009:adverse effects*; D057210:Delayed Diagnosis; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006760:Hospitalization; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008508:Medication Errors / Q000706:statistics & numerical data; D008875:Middle Aged; D010353:Patient Education as Topic; D060735:Pharmacovigilance; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D028761:Withholding Treatment / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D006993:Hypnotics and Sedatives; D001569:Benzodiazepines
keywords: Benzodiazepine; Benzodiazépine; Drug misuse; Erreur médicamenteuse; Medication error; Mésusage; Pharmacovigilance; Syndrome de sevrage; Withdrawal syndrome