title: Organ involvement other than lupus nephritis in childhood-onset systemic lupus erythematosus.
abstract: In this review we critically analyze pulmonary, gastrointestinal and cardiac manifestations of childhood-onset systemic lupus erythematosus (cSLE). Clinical manifestations of these organ systems may be the initial manifestation of cSLE; frequently occur with very active cSLE; and are potential life-threatening manifestations often presenting to the emergency department and requiring admission to the intensive care unit. Early recognition and treatment of the pulmonary, gastrointestinal and cardiac manifestations of cSLE will result in improved prognosis and better outcomes.
authors.affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, USA Jennifer.huggins@cchmc.org.
authors.forename: J L
authors.initials: JL
authors.lastname: Huggins
authors.affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Holland
authors.affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, USA.
authors.forename: H I
authors.initials: HI
authors.lastname: Brunner
mesh_terms: D017668:Age of Onset; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D002648:Child; D005767:Gastrointestinal Diseases / Q000503:physiopathology*; D006801:Humans; D008171:Lung Diseases / Q000503:physiopathology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D011379:Prognosis
keywords: Children; cSLE; cardiac; gastrointestinal; lupus; pulmonary