title: Residual Force Enhancement Following Eccentric Contractions: A New Mechanism Involving Titin.
abstract: Eccentric muscle properties are not well characterized by the current paradigm of the molecular mechanism of contraction: the cross-bridge theory. Findings of force contributions by passive structural elements a decade ago paved the way for a new theory. Here, we present experimental evidence and theoretical support for the idea that the structural protein titin contributes to active force production, thereby explaining many of the unresolved properties of eccentric muscle contraction.
authors.affiliation: University of Calgary Human Performance Laboratory, Calgary, Alberta, Canada wherzog@ucalgary.ca.
authors.forename: W
authors.initials: W
authors.lastname: Herzog
authors.affiliation: University of Calgary Human Performance Laboratory, Calgary, Alberta, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Schappacher
authors.affiliation: University of Calgary Human Performance Laboratory, Calgary, Alberta, Canada.
authors.forename: M
authors.initials: M
authors.lastname: DuVall
authors.affiliation: University of Calgary Human Performance Laboratory, Calgary, Alberta, Canada.
authors.forename: T R
authors.initials: TR
authors.lastname: Leonard
authors.affiliation: University of Calgary Human Performance Laboratory, Calgary, Alberta, Canada.
authors.forename: J A
authors.initials: JA
authors.lastname: Herzog
mesh_terms: D000818:Animals; D064211:Connectin / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000378:metabolism / Q000502:physiology*; D012518:Sarcomeres / Q000502:physiology
chemical_list: D064211:Connectin