title: A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity.
abstract: We sought to determine whether oxidative stress and anti-oxidative activity could act as biomarkers that discriminate patients with chronic fatigue syndrome (CFS) from healthy volunteers at acute and sub-acute fatigue and resting conditions. We calculated the oxidative stress index (OSI) from reactive oxygen metabolites-derived compounds (d-ROMs) and the biological antioxidant potential (BAP). We determined changes in d-ROMs, BAP, and OSI in acute and sub-acute fatigue in two healthy groups, and compared their values at rest between patients with CFS (diagnosed by Fukuda 1994 criteria) and another group of healthy controls. Following acute fatigue in healthy controls, d-ROMs and OSI increased, and BAP decreased. Although d-ROMs and OSI were significantly higher after sub-acute fatigue, BAP did not decrease. Resting condition yielded higher d-ROMs, higher OSI, and lower BAP in patients with CFS than in healthy volunteers, but lower d-ROMs and OSI when compared with sub-acute controls. BAP values did not significantly differ between patients with CFS and controls in the sub-acute condition. However, values were significantly higher than in the resting condition for controls. Thus, measured of oxidative stress (d-ROMS) and anti-oxidative activity (BAP) might be useful for discriminating acute, sub-acute, and resting fatigue in healthy people from patients with CFS, or for evaluating fatigue levels in healthy people.
authors.affiliation: University of Kansai Welfare Sciences, Kashiwara, Osaka 582-0026, Japan; RIKEN Center for Life Science Technologies, Kobe, Hyogo 650-0047, Japan; Department of Physiology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan. Electronic address: sfukuda@fuksi-kagk-u.ac.jp.
authors.forename: Sanae
authors.initials: S
authors.lastname: Fukuda
authors.affiliation: Department of Laboratory Science, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505, Japan.
authors.forename: Junzo
authors.initials: J
authors.lastname: Nojima
authors.affiliation: Department of Laboratory Science, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505, Japan.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Motoki
authors.affiliation: Department of Physiology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan; Department of Endocrinology, Metabolism and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors.forename: Kouzi
authors.initials: K
authors.lastname: Yamaguti
authors.affiliation: Department of Physiology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan; Department of Endocrinology, Metabolism and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Nakatomi
authors.affiliation: University of Kansai Welfare Sciences, Kashiwara, Osaka 582-0026, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Okawa
authors.affiliation: University of Kansai Welfare Sciences, Kashiwara, Osaka 582-0026, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Fujiwara
authors.affiliation: RIKEN Center for Life Science Technologies, Kobe, Hyogo 650-0047, Japan; Department of Physiology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: University of Kansai Welfare Sciences, Kashiwara, Osaka 582-0026, Japan; RIKEN Center for Life Science Technologies, Kobe, Hyogo 650-0047, Japan; Department of Physiology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan; Department of Endocrinology, Metabolism and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Kuratsune
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015673:Fatigue Syndrome, Chronic / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000097:blood*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D017382:Reactive Oxygen Species
keywords: Anti-oxidative activity; Fatigue; Oxidative stress