title: Effect of ATM-111 (G>A) Polymorphism on Cancer Risk: A Meta-Analysis.
abstract: OBJECTIVE
  To assess the relationship between the ataxia telangiectasia mutated (ATM) gene-111 (G>A) polymorphism and cancer risk.
  
  
  METHODS
  The PubMed, EMBASE, Web of Science, and China National Knowledge Infrastructure databases were searched comprehensively. A total of 16 case-control studies with 12,273 cases and 13,046 controls were included in this meta-analysis; 12 of them were from the Chinese population. Five studies assessed smoking effects, including 3038 smokers and 1003 nonsmokers. Odds ratio (OR) was determined by using a genetic model-free approach. Heterogeneity was quantified by I(2) statistics. Publication bias was also evaluated.
  
  
  RESULTS
  The recessive model (AA vs. AG + GG) was suggested as the most appropriate genetic model. After elimination of heterogeneity, it was found that the ATM-111 (G>A) AA genotype is significantly associated with increased susceptibility to overall cancer risk in a fixed effects model (OR = 1.09; 95% CI = 1.03-1.15; p < 0.01; I(2) < 0.01). In the subgroup analysis, the result of pooled analyses among the Chinese population revealed similar associations (OR = 1.12; 95% CI = 1.04-1.22; p < 0.01; I(2) < 0.01). As for specific cancer analysis, an increase was correlated with lung cancer risk (OR = 1.12; 95% CI = 1.01-1.24; p = 0.03) and breast cancer risk (OR = 1.08; 95% CI = 1.00-1.16; p = 0.05). In addition, a stronger association was found among nonsmokers (OR = 1.31; 95% CI = 1.13-1.52; p < 0.01).
  
  
  CONCLUSIONS
  This meta-analysis suggests that AA genotype of the ATM-111 gene (G>A) may be a risk factor for breast cancer and lung cancer, especially among nonsmokers, within the Chinese population.
authors.affiliation: 1 The First Clinical Medicine College, Southern Medical University , Guangzhou, People's Republic of China .
authors.forename: Senlin
authors.initials: S
authors.lastname: Huang
authors.affiliation: 2 Laboratory Medicine Center, Nanfang Hospital, Southern Medical University , Guangzhou, People's Republic of China .
authors.forename: Yuzhao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 2 Laboratory Medicine Center, Nanfang Hospital, Southern Medical University , Guangzhou, People's Republic of China .|3 School of Laboratory Medicine, Guangdong Medical University , Dongguan, People's Republic of China .
authors.forename: Tao
authors.initials: T
authors.lastname: Zeng
mesh_terms: D044466:Asian People / Q000235:genetics; D064007:Ataxia Telangiectasia Mutated Proteins / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D002681:China; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins