title: Outcome of pleurodesis using different agents in management prolonged air leakage following lung resection.
abstract: OBJECTIVE
  Prolonged air leaks (PAL) are a common problem after pulmonary resection. PAL can be a source of significant complications. One of the treatment options is chemical pleurodesis.
  
  
  METHODS
  The efficiency of three methods of treatment of PAL after lung resection was evaluated. In Iodine_ group aqueous iodine solution (lat.Tinctura Jodi) was applied intrapleurally (30 patients); in Doxycycline_group (34 patients) 200 mg of Doxycyclin was given and in Drainage_group 35 patients were applied Lidocaine solution only.
  
  
  RESULTS
  The group investigated was similar with regard to age [F = 0.04, P = 0.96] and the amount of air leakage (approx. 462 mL/min). The shortest drainage time and hospital stay was observed in the Iodine_group [10.57, P < 0.001]. However, this therapy was connected with strongly perceptible chest pain (P < 0.0001]). The number of case of pneumothorax recurrence was low and it was the same was seen in other methods of treatment [F = 0.87, P = 0.42]. Allergic reactions were not observed. The number of episodes of tachycardia, hypotension, dyspnea, pneumonia, subcutaneus empyema, fluid collection, emphysema, pneumothorax recurrence and number of re-thoracotomies were statistically similar in all three methods of treatment.
  
  
  CONCLUSIONS
  Iodine pleurodesis can be considered as one of possible treatment methods of PAL after lung resection as it showed favorable results compared with Doxycycline pleurodesis or drainage alone regarding duration of air leakage, hospitalization and pneumothorax recurrence with only slightly increased pleural pain.
authors.affiliation: Department of Thoracic, General and Oncological Surgery, Medical University of Lodz, Łódź, Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Jabłoński
authors.affiliation: Department of Thoracic, General and Oncological Surgery, Medical University of Lodz, Łódź, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Kordiak
authors.affiliation: Department of Thoracic, General and Oncological Surgery, Medical University of Lodz, Łódź, Poland.
authors.forename: Szymon
authors.initials: S
authors.lastname: Wcisło
authors.affiliation: Department of Thoracic, General and Oncological Surgery, Medical University of Lodz, Łódź, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Terlecki
authors.affiliation: Department of Thoracic, General and Oncological Surgery, Medical University of Lodz, Łódź, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Misiak
authors.affiliation: Department of Thoracic, General and Oncological Surgery, Medical University of Lodz, Łódź, Poland.
authors.forename: Edyta
authors.initials: E
authors.lastname: Santorek-Strumiłło
authors.affiliation: Department of Thoracic, General and Oncological Surgery, Medical University of Lodz, Łódź, Poland.
authors.forename: Jerry
authors.initials: J
authors.lastname: Lazarek
authors.affiliation: Department of Maxillofacial Surgery, Medical University of Lodz, Łódź, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Kozakiewicz
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D004318:Doxycycline / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007455:Iodine / Q000008:administration & dosage*; D008297:Male; D018700:Pleurodesis / Q000379:methods*; D011013:Pneumonectomy / Q000009:adverse effects*; D011030:Pneumothorax / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D011183:Postoperative Complications; D012307:Risk Factors; D013396:Suction / Q000379:methods*; D020775:Thoracic Surgery, Video-Assisted; D016896:Treatment Outcome; D014797:Vital Capacity
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D007455:Iodine; D004318:Doxycycline
keywords: alveolar air leaks; chemical pleurodesis; iodin pleurodesis; lung resection; prolonged air leak