title: [Study on Raman Spectra of Some Clinical Medicine].
abstract: Aiming at the shortage of the Raman spectra of drugs and the current situation of drug testing, we have applied Raman spectroscopic technique to several kinds of medicine, such as antibiotics, antihistamine, hemocoagulase and antiemetics. The spectral properties for the samples with high Raman activity are investigated by observing their Raman spectra to yield the shift, intensity, and line width of the Raman peaks, as well as the line shape of Raman envelope. For those samples with weak Raman activity or complex structures that are hard to be identified, we have also made some tentative measurements or raise some suggestions for future measurement. Comparing the similarities or differences among many Raman spectra of drugs, it is evident that drugs with small molecule have apparent spectral characteristics, by which to recognize them is very feasible, while those with large molecule usually have weak peaks or complex envelope in their spectra, leading to a difficult recognition and uncertain peak positions. This work not only proposes to identify chemical ingredients of drugs by observing and analyzing their Raman spectra, but also provides experimental evidences for medical workers doing so. The present results lay the foundation for establish the database of Raman spectra for drugs, and point out the prospect for rapid identification and detection of drugs, promoting the application of Raman spectroscopy technology on drug detection to a certain extent.
authors.forename: He
authors.initials: H
authors.lastname: Dong
authors.forename: Chuan
authors.initials: C
authors.lastname: Liu
authors.forename: Chang-Jian
authors.initials: CJ
authors.lastname: Dai
mesh_terms: D016208:Databases, Factual; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013059:Spectrum Analysis, Raman
chemical_list: D004364:Pharmaceutical Preparations