title: White and gray matter fiber pathways in autism spectrum disorder revealed by ex vivo diffusion MR tractography.
abstract: The goal of this project was to study the white and gray matter brain pathways of young children with autism spectrum disorder (ASD) and investigate how ASD brains differ from those of typically developing children of the same age.
  
  
  
  High angular resolution resolution diffusion imaging tractography and diffusion tensor imaging tractography were used to analyze the brains of two 3-year-old children with ASD and two age-matched controls.
  
  
  
  In the ASD brains, the callosal and corticopontine pathways were thinner overall and terminal areas in the cortical gray matter were significantly smaller. The ASD brains had more short-range u-fibers in the frontal lobe compared to the control brains. Gray matter pathways were found disorganized with less coherency in the ASD brain, specifically the lateral aspects of the middle part of the brain including motor areas, and both medial and lateral surfaces of the anterior frontal brain regions.
  
  
  
  These findings show our tractography technique is useful for identifying differences in brain pathways between the ASD and control groups. Given that scanning the brain of 3-year-old children with or even without ASD is challenging, postmortem scanning may offer valuable insights into the connectivity in the brain of young children with ASD.
authors.affiliation: Department of Behavioral Neuroscience Northeastern University Boston Massachusetts; Division of Newborn Medicine Department of Medicine Boston Children's Hospital Harvard Medical School Boston Massachusetts.
authors.forename: Molly
authors.initials: M
authors.lastname: Wilkinson
authors.affiliation: Division of Newborn Medicine Department of Medicine Boston Children's Hospital Harvard Medical School Boston Massachusetts.
authors.forename: Rongpin
authors.initials: R
authors.lastname: Wang
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Harvard Medical School Charlestown Massachusetts.
authors.forename: Andre
authors.initials: A
authors.lastname: van der Kouwe
authors.affiliation: Division of Newborn Medicine Department of Medicine Boston Children's Hospital Harvard Medical School Boston Massachusetts; Fetal-Neonatal Neuroimaging and Developmental Science Center Boston Children's Hospital Harvard Medical School Boston Massachusetts.
authors.forename: Emi
authors.initials: E
authors.lastname: Takahashi
mesh_terms: D000067877:Autism Spectrum Disorder / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000000981:diagnostic imaging; D002675:Child, Preschool; D003337:Corpus Callosum / Q000000981:diagnostic imaging; D056324:Diffusion Tensor Imaging; D066128:Gray Matter / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D066127:White Matter / Q000000981:diagnostic imaging*
keywords: Brain; callosal pathways; corticopontine pathways; development; ex vivo imaging; high‐angular resolution diffusion imaging; tractography