title: Aminoglycosides: An Overview.
abstract: Aminoglycosides are natural or semisynthetic antibiotics derived from actinomycetes. They were among the first antibiotics to be introduced for routine clinical use and several examples have been approved for use in humans. They found widespread use as first-line agents in the early days of antimicrobial chemotherapy, but were eventually replaced in the 1980s with cephalosporins, carbapenems, and fluoroquinolones. Aminoglycosides synergize with a variety of other antibacterial classes, which, in combination with the continued increase in the rise of multidrug-resistant bacteria and the potential to improve the safety and efficacy of the class through optimized dosing regimens, has led to a renewed interest in these broad-spectrum and rapidly bactericidal antibacterials.
authors.affiliation: Achaogen, South San Francisco, California 94080.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Krause
authors.affiliation: Achaogen, South San Francisco, California 94080.
authors.forename: Alisa W
authors.initials: AW
authors.lastname: Serio
authors.affiliation: Achaogen, South San Francisco, California 94080.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Kane
authors.affiliation: Achaogen, South San Francisco, California 94080 Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, San Francisco, California 94143.
authors.forename: Lynn E
authors.initials: LE
authors.lastname: Connolly
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015195:Drug Design; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D012336:RNA, Ribosomal, 16S / Q000378:metabolism
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D012336:RNA, Ribosomal, 16S