title: [The efficacy of combination therapy with mexidol and cerebrolysin in chronic cerebral ischemia].
abstract: OBJECTIVE
  To study the impact of combination therapy with mexidol and cerebrolysin on the clinical status of patients with chronic cerebral ischemia (CCI), II stage, in ambulatory conditions.
  
  
  METHODS
  The study included 36 patients with CCI, II stage. In addition to basic therapy, patients received two courses of the mexidol/cerebrolysin combination during 6 weeks with 3 month-interval between the courses. The dynamics of subjective complaints of the patients and objective clinical signs was assessed after each course. The content of 13 chemical elements in the hair was determined by atomic-emission method after the treatment.
  
  
  CONCLUSIONS
  Based on the results of clinical and neurological study, the efficacy of combination therapy with mexidol and cerebrolysin as long-term neuroprotection drugs was shown which manifested a significant reduction in the severity of all major symptoms under the influence of the therapy.
authors.affiliation: City Hospital #6, Kazan, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Berezhnaya
authors.affiliation: Kazan State Medical University, Kazan, Russia.
authors.forename: E Z
authors.initials: EZ
authors.lastname: Yakupov
authors.affiliation: Institut of Physics of Kazan Volga Region Federal University, Kazan, Russia.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Zaharov
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004602:Elements; D005260:Female; D006197:Hair / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010847:Picolines / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000596:Amino Acids; D000975:Antioxidants; D004602:Elements; D018696:Neuroprotective Agents; D010847:Picolines; C070020:emoxypine succinate; C006952:cerebrolysin