title: [Cardiac pathologies and aging: lessons from a tiny heart].
abstract: The high level of conservation of the cardiogenic gene regulatory network as well as of the cellular and physiological characteristics of the cardiomyocytes between fly and human, makes the small heart of this invertebrate the simplest and most flexible genetic system to dissect the fundamental molecular mechanisms that are brought into play during the development, the establishment and the maintenance of the cardiac function. The recent improvements in techniques of measurements of cardiac function made it possible to validate Drosophila as a model of cardiomyopathies and arrhythmias of genetic and metabolic origin or dependent of ageing. The heart of the fly thus represents a model of choice to identify genes and their interactions implicated in cardiac pathologies.
authors.affiliation: Inserm UMR_S 1090, Technological advances for genomics and clinics (TAGC), parc scientifique de Luminy, case 908, 13288 Marseille Cedex 9, France - CNRS, Marseille, France - Aix-Marseille université, UMR_S 1090, TAGC, parc scientifique de Luminy, 13288 Marseille, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Perrin
authors.affiliation: Inserm UMR_S 1090, Technological advances for genomics and clinics (TAGC), parc scientifique de Luminy, case 908, 13288 Marseille Cedex 9, France - Aix-Marseille université, UMR_S 1090, TAGC, parc scientifique de Luminy, 13288 Marseille, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Röder
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000196:embryology / Q000502:physiology; D004625:Embryo, Nonmammalian; D006321:Heart / Q000196:embryology / Q000254:growth & development / Q000503:physiopathology; D006331:Heart Diseases / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D032383:Myocytes, Cardiac / Q000502:physiology