title: Associations between body composition and nutritional assessments and biochemical markers in patients with chronic radiation enteritis: a case-control study.
abstract: Chronic radiation enteritis (CRE) is defined as loss of absorptive capacity after irradiation due to chronic inflammation and damage of intestinal mucosa, which may lead to varying degrees of malnutrition. The aim of this study was to evaluate the potential correlation between the nutritional status and systemic inflammation in patients with CRE.
  
  
  
  Medical records of 92 patients with CRE and 184 age- and sex-matched controls in a single center from January 2010 to October 2015 were retrospectively reviewed. All enrolled subjects underwent nutritional status analysis, including three different nutritional indices: Nutritional Risk Screening-2002 (NRS-2002), Patient-generated Subjective Global Assessment (PG-SGA) and Controlling Nutritional Status (CONUT), bioelectrical impedance spectroscopy (BIS), and biochemical markers, within 24 h of admission.
  
  
  
  The results showed that NRS-2002, PG-SGA and CONUT were all positively correlated with neutrophil/lymphocyte ratio (NLR) (r = 0.304, 0.384 and 0.425, all p < 0.001) and C-reactive protein (CRP) (r = 0.357, 0.479 and 0.230, all p < 0.001), while negatively correlated with albumin (r = -0.612, -0.727 and -0.792, all p < 0.001) and total cholesterol (TC) (r = -0.485, -0.545 and -0.473, all p < 0.001) in patients with CRE, respectively. Body cell mass (BCM) has been deemed a key body composition parameter. It was positively correlated with albumin (r = 0.489, p < 0.001) and TC (r = 0.237, p < 0.001), while negatively correlated with NLR (r = -0.140, p = 0.02) and CRP (r = -0.215, p < 0.001). A multivariate linear regression analysis showed that values of intracellular water (β coefficient = 0.760, p < 0.001), extracellular water (β coefficient = 0.006, p = 0.011), protein (β coefficient = 0.235, p < 0.001) and CRP (β coefficient = 0.001, p = 0.009) were independent determinants of BCM.
  
  
  
  This study revealed that BIS combined with nutritional assessments and biochemical markers were appropriate methods to assess the nutritional and inflammatory status in patients with CRE. Furthermore, the nutritional status was verified to be significantly correlated with systemic inflammation.
authors.affiliation: Department of Surgery, Nanjing Clinical College of the Secondary Military Medical University, Nanjing, Jiangsu, 210002, China.|Department of Surgery, Jinling hospital, 305 East Zhongshan Road, Nanjing, Jiangsu, 210002, China.
authors.forename: Zhongliang
authors.initials: Z
authors.lastname: Cai
authors.affiliation: Department of Radiology, Hangzhou Sanatorium of Nanjing Command, PLA, Hangzhou, Zhejiang, 310007, China.
authors.forename: Da
authors.initials: D
authors.lastname: Cai
authors.affiliation: Department of Surgery, Jinling hospital, 305 East Zhongshan Road, Nanjing, Jiangsu, 210002, China.
authors.forename: Danhua
authors.initials: D
authors.lastname: Yao
authors.affiliation: Department of Surgery, Nanjing Clinical College of the Secondary Military Medical University, Nanjing, Jiangsu, 210002, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Surgery, Jinling hospital, 305 East Zhongshan Road, Nanjing, Jiangsu, 210002, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Surgery, Jinling hospital, 305 East Zhongshan Road, Nanjing, Jiangsu, 210002, China. liys@medmail.com.cn.
authors.forename: Yousheng
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001823:Body Composition; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D017097:Electric Impedance; D004751:Enteritis / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007249:Inflammation; D016014:Linear Models; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D044342:Malnutrition / Q000097:blood* / Q000209:etiology; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils / Q000166:cytology; D015596:Nutrition Assessment; D009752:Nutritional Status; D011878:Radiotherapy / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; D002097:C-Reactive Protein; D002784:Cholesterol; D003404:Creatinine
keywords: Biochemical markers; Body composition; Chronic radiation enteritis; Nutritional assessment