title: Prevalence of Intracranial Aneurysms in Patients with Aortic Aneurysms.
abstract: Previous studies have suggested an association between aortic aneurysms and intracranial aneurysms with a higher prevalence of intracranial aneurysms in patients with aortic aneurysms. The aims of the present study were to evaluate the incidence of intracranial aneurysms in a large cohort of patients with aortic aneurysms and to identify potential risk factors for intracranial aneurysms in this population.
  
  
  
  We included all patients with aortic aneurysms (either abdominal and/or thoracic) who had available cerebral arterial imaging and were seen at our institution during a 15-year period. We identified patients with intracranial aneurysms. Patient demographics, comorbidities, and aortic aneurysm and intracranial aneurysm sizes and locations were analyzed. Univariate analysis was performed with a χ(2) test for categoric variables and a Student t test or ANOVA for continuous variables.
  
  
  
  A total of 1081 patients with aortic aneurysms were included. Of them, 440 (40.7%) had abdominal aortic aneurysms, 446 (41.3%) had thoracic aortic aneurysms, and 195 (18.0%) had both abdominal aortic and thoracic aortic aneurysms. The overall prevalence of associated intracranial aneurysms in patients with aortic aneurysms was 11.8% (128/1081), with 12.7% (56/440), 10.8% (48/446), and 12.3% (24/195), respectively, in patients with abdominal aortic aneurysms, thoracic aortic aneurysms, and both thoracic aortic aneurysms and abdominal aortic aneurysms. Female patients had a higher risk of associated intracranial aneurysms (OR = 2.08; 95% CI, 1.49-3.03; P = .0002). There was a slight association between abdominal aortic aneurysm size and the prevalence of intracranial aneurysms (OR = 1.02; 95% CI, 1.01-1.03; P = .045). There was no significant association between the locations of the aortic and intracranial aneurysms (P = .93).
  
  
  
  The prevalence of intracranial aneurysms is high in patients with aortic aneurysms. Further studies examining the role and cost-effectiveness of intracranial aneurysm screening in patients are warranted.
authors.affiliation: From the Departments of Radiology (A.R., M.D.B., A.M.R., R.K., D.F.K., W.B.) aymeric.rouchaud@gmail.com.
authors.forename: A
authors.identifier: 0000-0003-0902-3375
authors.initials: A
authors.lastname: Rouchaud
authors.affiliation: From the Departments of Radiology (A.R., M.D.B., A.M.R., R.K., D.F.K., W.B.).
authors.forename: M D
authors.identifier: 0000-0002-5964-0534
authors.initials: MD
authors.lastname: Brandt
authors.affiliation: From the Departments of Radiology (A.R., M.D.B., A.M.R., R.K., D.F.K., W.B.).
authors.forename: A M
authors.identifier: 0000-0002-6647-4159
authors.initials: AM
authors.lastname: Rydberg
authors.affiliation: From the Departments of Radiology (A.R., M.D.B., A.M.R., R.K., D.F.K., W.B.).
authors.forename: R
authors.identifier: 0000-0002-6786-9953
authors.initials: R
authors.lastname: Kadirvel
authors.affiliation: Neurology (K.F.), Mayo Clinic, Rochester, Minnesota.
authors.forename: K
authors.identifier: 0000-0001-6021-1190
authors.initials: K
authors.lastname: Flemming
authors.affiliation: From the Departments of Radiology (A.R., M.D.B., A.M.R., R.K., D.F.K., W.B.).
authors.forename: D F
authors.identifier: 0000-0002-8495-0040
authors.initials: DF
authors.lastname: Kallmes
authors.affiliation: From the Departments of Radiology (A.R., M.D.B., A.M.R., R.K., D.F.K., W.B.).
authors.forename: W
authors.identifier: 0000-0001-5271-5524
authors.initials: W
authors.lastname: Brinjikji
mesh_terms: D000368:Aged; D001014:Aortic Aneurysm / Q000150:complications*; D015897:Comorbidity; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors