title: Antibodies to myelin basic protein are associated with cognitive decline after stroke.
abstract: B lymphocytes cause post-stroke cognitive decline in mice. We therefore evaluated the association between autoantibodies and post-stroke cognitive decline in a prospectively collected human cohort. The mini-mental state exam (MMSE) was administered 30, 90, 180, and 365days after stroke. Antibody titers to myelin basic protein (MBP), proteolipid protein, and several non-specific proteins were determined. Among 58 subjects with initial MMSE≥20 and at least 2 MMSE examinations in the year after stroke, cognitive decline (MMSE decrease ≥2) occurred in 10 (17%) subjects. In multivariate analysis, MBP antibody titers were the only independent predictor of cognitive decline (OR=9.02 [1.18, 68.90]; P=0.03).
authors.affiliation: Department of Neurology, University of Washington School of Medicine, United States. Electronic address: kjb@uw.edu.
authors.forename: Kyra J
authors.initials: KJ
authors.lastname: Becker
authors.affiliation: Department of Neurology, University of Washington School of Medicine, United States.
authors.forename: Patricia
authors.initials: P
authors.lastname: Tanzi
authors.affiliation: Department of Neurology, University of Washington School of Medicine, United States.
authors.forename: Dannielle
authors.initials: D
authors.lastname: Zierath
authors.affiliation: Departments of Neurology and Neurological Sciences, and Neurosurgery, Stanford University School of Medicine, United States.
authors.forename: Marion S
authors.initials: MS
authors.lastname: Buckwalter
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000378:metabolism*; D003072:Cognition Disorders / Q000209:etiology* / Q000276:immunology*; D015331:Cohort Studies; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000276:immunology*; D018991:Myelin Proteolipid Protein / Q000276:immunology; D009483:Neuropsychological Tests; D020521:Stroke / Q000150:complications*
chemical_list: D001323:Autoantibodies; D004676:Myelin Basic Protein; D018991:Myelin Proteolipid Protein; C472930:PLP1 protein, human
keywords: Autoimmune; Cognitive decline; MBP antibodies; Stroke