title: (18)F-FDG uptake by rectal cancer is similar in mucinous and nonmucinous histological subtypes.
abstract: OBJECTIVE
  PET/CT has been considered limited for the evaluation of mucinous colorectal tumors due to low (18)F-FDG uptake. The aim of our study was to compare PET/CT variables in mucinous (MC) and nonmucinous (NMC) rectal adenocarcinomas.
  
  
  METHODS
  Consecutive patients with cT2-4N0-2M0 rectal cancer included in a prospective clinical trial were reviewed. PET/CT was performed for primary baseline staging. Visual and quantitative analysis included SUVmax and SUVmean, metabolic tumor volume (MTV) and total lesion glycolysis (TLG). PET/CT parameters were compared according to histological subtypes.
  
  
  RESULTS
  Overall, 73 patients were included (18 mucinous and 55 nonmucinous). SUVmax values were similar between MC and NMC (19.7 vs. 16.6; p = 0.5). MTV and TLG values were greater in the MC group (103.9 vs. 54.1; p = 0.007 and 892.5 vs. 358.8; p = 0.020) due to larger tumor volumes of MC.
  
  
  CONCLUSIONS
  Metabolic parameters at baseline PET/CT for patients with rectal cancer are similar in mucinous and nonmucinous histological subtypes.
authors.affiliation: University of Brasília Medical School, Av. L2 Norte quadra 605, Brasília, DF, 70840-901, Brazil. dalton.anjos@ebserh.gov.br.|Hospital Universitário de Brasília, Unidade de Medicina Nuclear, Av. L2 Norte, quadra 605, anexo 2, Brasília, DF, 70840-901, Brazil. dalton.anjos@ebserh.gov.br.
authors.forename: Dalton A
authors.initials: DA
authors.lastname: Dos Anjos
authors.affiliation: Angelita & Joaquim Gama Institute, Rua Manoel da Nóbrega 1564, São Paulo, SP, 04001-005, Brazil.
authors.forename: Angelita
authors.initials: A
authors.lastname: Habr-Gama
authors.affiliation: Angelita & Joaquim Gama Institute, Rua Manoel da Nóbrega 1564, São Paulo, SP, 04001-005, Brazil.
authors.forename: Bruna B
authors.initials: BB
authors.lastname: Vailati
authors.affiliation: Angelita & Joaquim Gama Institute, Rua Manoel da Nóbrega 1564, São Paulo, SP, 04001-005, Brazil.
authors.forename: Cecilia B
authors.initials: CB
authors.lastname: Rossi
authors.affiliation: Angelita & Joaquim Gama Institute, Rua Manoel da Nóbrega 1564, São Paulo, SP, 04001-005, Brazil.
authors.forename: Adelina E
authors.initials: AE
authors.lastname: Coturel
authors.affiliation: Angelita & Joaquim Gama Institute, Rua Manoel da Nóbrega 1564, São Paulo, SP, 04001-005, Brazil.|Colorectal Surgery Division, University of São Paulo School of Medicine, Av. Dr. Enéas de Carvalho Aguiar, 255, São Paulo, SP, 05403-000, Brazil.
authors.forename: Rodrigo O
authors.initials: RO
authors.lastname: Perez
authors.affiliation: Angelita & Joaquim Gama Institute, Rua Manoel da Nóbrega 1564, São Paulo, SP, 04001-005, Brazil.
authors.forename: Guilherme P
authors.initials: GP
authors.lastname: São Julião
authors.affiliation: University of Brasília Medical School, Av. L2 Norte quadra 605, Brasília, DF, 70840-901, Brazil.
authors.forename: João B
authors.initials: JB
authors.lastname: de Sousa
authors.affiliation: Department of Radiology and Nuclear Medicine, Hospital do Coração, Rua Desembargador Eliseu Guilherme, 147, São Paulo, SP, 04004-030, Brazil.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Buchpiguel
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001692:Biological Transport; D005188:False Negative Reactions; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D047368:Tumor Burden
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: 18F-FDG PET/CT; Mucinous adenocarcinoma; Rectal cancer