title: Novel roles of Src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and metastasis.
abstract: The Src-family kinases (SFKs), an intracellularly located group of non-receptor tyrosine kinases are involved in oncogenesis. The importance of SFKs has been implicated in the promotion of tumor cell motility, proliferation, inhibition of apoptosis, invasion and metastasis. Recent evidences indicate that specific effects of SFKs on epithelial-to-mesenchymal transition (EMT) as well as on endothelial and stromal cells in the tumor microenvironment can have profound effects on tumor microinvasion and metastasis. Although, having been studied extensively, these novel features of SFKs may contribute to greater understanding of benefits from Src inhibition in various types of cancers. Here we review the novel role of SFKs, particularly c-Src in mediating EMT, modulation of tumor endothelial-barrier, transendothelial migration (microinvasion) and metastasis of cancer cells, and discuss the utility of Src inhibitors in vascular normalization and cancer therapy.
authors.affiliation: Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA, United States.
authors.forename: Ami
authors.initials: A
authors.lastname: Patel
authors.affiliation: Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA, United States; Charlie Norwood VA Medical Center, Augusta, GA, United States.
authors.forename: Harika
authors.initials: H
authors.lastname: Sabbineni
authors.affiliation: Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA, United States.
authors.forename: Andrea
authors.initials: A
authors.lastname: Clarke
authors.affiliation: Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA, United States; Charlie Norwood VA Medical Center, Augusta, GA, United States; Department of Medicine, Vascular Biology Center and Cancer Center, Augusta University, Augusta, GA, United States. Electronic address: sshenoy@augusta.edu.
authors.forename: Payaningal R
authors.initials: PR
authors.lastname: Somanath
mesh_terms: D002199:Capillary Permeability / Q000502:physiology*; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology*; D019061:src-Family Kinases / Q000502:physiology*
chemical_list: D019061:src-Family Kinases
keywords: EMT; Metastasis; Microinvasion; Src; Vascular permeability