title: Genetic polymorphisms of pharmacogenomic VIP variants in the Mongol of Northwestern China.
abstract: Within a population, the differences of pharmacogenomic variant frequencies may produce diversities in drug efficacy, safety, and the risk associated with adverse drug reactions. With the development of pharmacogenomics, widespread genetic research on drug metabolism has been conducted on major populations, but less is known about minorities.
  
  
  
  In this study, we recruited 100 unrelated, healthy Mongol adults from Xinjiang and genotyped 85 VIP variants from the PharmGKB database. We compared our data with eleven populations listed in 1000 genomes project and HapMap database. We used χ(2) tests to identify significantly different loci between these populations. We downloaded SNP allele frequencies from the ALlele FREquency Database to observe the global genetic variation distribution for these specific loci. And then we used Structure software to perform the genetic structure analysis of 12 populations.
  
  
  
  Our results demonstrated that different polymorphic allele frequencies exist between different nationalities,and indicated Mongol is most similar to Chinese populations, followed by JPT. This information on the Mongol population complements the existing pharmacogenomic data and provides a theoretical basis for screening and therapy in the different ethnic groups within Xinjiang.
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, 712082, China. jintianbo@gmail.com.|Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, #6 East Wenhui Road, Xianyang, 712082, Shaanxi, China. jintianbo@gmail.com.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an, 710069, China. jintianbo@gmail.com.|School of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, China. jintianbo@gmail.com.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, 712082, China.|Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, #6 East Wenhui Road, Xianyang, 712082, Shaanxi, China.
authors.forename: Xugang
authors.initials: X
authors.lastname: Shi
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, 712082, China.|Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, #6 East Wenhui Road, Xianyang, 712082, Shaanxi, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems, Xi'an, 710069, China.|School of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Wang
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems, Xi'an, 710069, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Feng
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, 712082, China. kanglongli6211@163.com.|Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, #6 East Wenhui Road, Xianyang, 712082, Shaanxi, China. kanglongli6211@163.com.
authors.forename: Longli
authors.initials: L
authors.lastname: Kang
mesh_terms: D000328:Adult; D002681:China / Q000208:ethnology; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic
keywords: Genetic polymorphisms; Mongol; Pharmacogenomics; VIP variant