title: Dietary, circulating beta-carotene and risk of all-cause mortality: a meta-analysis from prospective studies.
abstract: Observational studies evaluating the relation between dietary or circulating level of beta-carotene and risk of total mortality yielded inconsistent results. We conducted a comprehensive search on publications of PubMed and EMBASE up to 31 March 2016. Random effect models were used to combine the results. Potential publication bias was assessed using Egger's and Begg's test. Seven studies that evaluated dietary beta-carotene intake in relation to overall mortality, indicated that a higher intake of beta-carotene was related to a significant lower risk of all-cause mortality (RR for highest vs. lowest group = 0.83, 95%CI: 0.78-0.88) with no evidence of heterogeneity between studies (I(2) = 1.0%, P = 0.416). A random-effect analysis comprising seven studies showed high beta-carotene level in serum or plasma was associated with a significant lower risk of all-cause mortality (RR for highest vs. lowest group = 0.69, 95%CI: 0.59-0.80) with low heterogeneity (I(2) = 37.1%, P = 0.145). No evidence of publication bias was detected by Begg's and Egger's regression tests. In conclusion, dietary or circulating beta-carotene was inversely associated with risk of all-cause mortality. More studies should be conducted to clarify the dose-response relationship between beta-carotene and all-cause mortality.
authors.affiliation: Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Long-Gang
authors.initials: LG
authors.lastname: Zhao
authors.affiliation: Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Qing-Li
authors.initials: QL
authors.lastname: Zhang
authors.affiliation: University of South Carolina, Arnold School of Public Health, Department of Epidemiology and Biostatistics, Columbia, SC29208, USA.
authors.forename: Jia-Li
authors.initials: JL
authors.lastname: Zheng
authors.affiliation: Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Hong-Lan
authors.initials: HL
authors.lastname: Li
authors.affiliation: Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Tang
authors.affiliation: Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000401:mortality*; D004032:Diet / Q000145:classification; D005260:Female; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000378:metabolism / Q000401:mortality*; D008875:Middle Aged; D009369:Neoplasms / Q000378:metabolism / Q000401:mortality*; D064209:Phytochemicals / Q000008:administration & dosage*; D011446:Prospective Studies; D016019:Survival Analysis; D019207:beta Carotene / Q000008:administration & dosage*
chemical_list: D064209:Phytochemicals; D019207:beta Carotene