title: Disseminated Hormographiella aspergillata infection with involvement of the lung, brain, and small intestine following allogeneic hematopoietic stem cell transplantation: case report and literature review.
abstract: Disseminated infection by Hormographiella aspergillata is extremely rare and small intestine involvement has not been reported previously. A 51-year-old man with myelodysplastic syndrome developed pneumonia after cord blood cell transplantation. Fungal growth from the biopsied lung was identified as H. aspergillata by morphology and the gene analysis. Although antifungal agents including voriconazole and liposomal amphotericin B were administered, he died of disseminated H. aspergillata infection. We review the literature and discuss the treatment and prognosis.
authors.affiliation: Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nanno
authors.affiliation: Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakane
authors.affiliation: Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Okamura
authors.affiliation: Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nishimoto
authors.affiliation: Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Koh
authors.affiliation: Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakamae
authors.affiliation: Diagnostic Pathology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ohsawa
authors.affiliation: Medical Mycology Research Center, Chiba University, Chiba, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yarita
authors.affiliation: Medical Mycology Research Center, Chiba University, Chiba, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kamei
authors.affiliation: Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hino
mesh_terms: D000363:Agaricales / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D020314:Central Nervous System Fungal Infections / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D004271:DNA, Fungal; D006086:Graft vs Host Disease / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects* / Q000379:methods; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007410:Intestinal Diseases / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology; D000072742:Invasive Fungal Infections / Q000097:blood / Q000188:drug therapy / Q000382:microbiology*; D008172:Lung Diseases, Fungal / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000601:surgery; D009503:Neutropenia / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology; D035583:Rare Diseases / Q000097:blood / Q000188:drug therapy / Q000382:microbiology*; D017422:Sequence Analysis, DNA; D014057:Tomography, X-Ray Computed; D019172:Transplantation Conditioning / Q000009:adverse effects / Q000379:methods; D014184:Transplantation, Homologous / Q000009:adverse effects
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D007166:Immunosuppressive Agents
keywords: Hormographiella aspergillata; allogeneic hematopoietic stem cell transplantation