title: [Connections between sleep and Alzheimer's disease : Insomnia, amnesia and amyloid].
abstract: Sleep plays an essential role in memory consolidation. Although sleep problems are common in Alzheimer's disease, they are not usually thought to be key features of the disease; however, new experimental research has shown that sleep disturbances not only occur before the onset of typical cognitive deficits but are also associated with the pathogenesis of Alzheimer's disease and may have a decisive influence on the symptoms and course. Thus, sleep disturbances may be potentially modifiable risk factors for Alzheimer's disease that deserve more attention in research, diagnostics and treatment.
authors.affiliation: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum rechts der Isar, Technische Universität München, München, Deutschland. aurel.busche@tum.de.|Institut für Neurowissenschaften, Technische Universität München, München, Deutschland. aurel.busche@tum.de.|Munich Cluster for Systems Neurology (SyNergy), München, Deutschland. aurel.busche@tum.de.
authors.forename: M A
authors.initials: MA
authors.lastname: Busche
authors.affiliation: Institut für Neurowissenschaften, Technische Universität München, München, Deutschland.|Munich Cluster for Systems Neurology (SyNergy), München, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Kekuš
authors.affiliation: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum rechts der Isar, Technische Universität München, München, Deutschland.
authors.forename: H
authors.initials: H
authors.lastname: Förstl
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000503:physiopathology*; D000647:Amnesia / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D019317:Evidence-Based Medicine; D006801:Humans; D008959:Models, Neurological; D058225:Plaque, Amyloid / Q000150:complications / Q000503:physiopathology*; D012890:Sleep; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications / Q000503:physiopathology*
keywords: Alzheimer´s disease; Memory consolidation; Non-REM sleep; Sleep disturbances; Slow-wave oscillations