title: Serum Phenobarbitone Levels in Term and Near Term Neonates with Seizures.
abstract: OBJECTIVE
  To evaluate serum phenobarbitone levels in neonates with seizures and to evaluate the effect of repeated loading dose on serum phenobarbitone levels.
  
  
  METHODS
  In this prospective observational study conducted in a tertiary care centre of Northern India during 2011- 2012, 99 neonates admitted with seizureswere included.Serum phenobarbitone levels in neonates with seizures at 20 minutes and 12 hours after the first loading dose of phenobarbitone were measured.
  
  
  RESULTS
  Serum phenobarbitone levels [mean (SD)] at 20 min and 12 hours was 27.3 (28.4) ug/mL and 23 (19.1) ug/mL, respectively (P=0.07). The mean serum phenobarbitone levels 12 hours after the loading dose, and proportion of neonates with toxic levels increased with each loading dose of intravenous phenobarbitone.
  
  
  CONCLUSIONS
  Monitoring of serum level of phonobarbitone may not be essential because seizure control in neonates appears to be independent of whether serum level is subtherapeutic, therapeutic or toxic range.
authors.affiliation: Department of Pediatrics, Lala Lajpat Rai Memorial Medical College, Meerut; and #Institute of Human Behavior and Allied Sciences, New Delhi; India. Correspondence to: Dr Amit Upadhyay, Head, Department of Pediatrics, LLRM Medical College, Meerut, India. au.llrm@gmail.com.
authors.forename: Sanober
authors.initials: S
authors.lastname: Wasim
authors.forename: Amit
authors.initials: A
authors.lastname: Upadhyay
authors.forename: Monica
authors.initials: M
authors.lastname: Roy
authors.forename: Pranjali
authors.initials: P
authors.lastname: Saxena
authors.forename: Neelam
authors.initials: N
authors.lastname: Chillar
mesh_terms: D000927:Anticonvulsants / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D016903:Drug Monitoring; D020936:Epilepsy, Benign Neonatal / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D010634:Phenobarbital / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D011446:Prospective Studies
chemical_list: D000927:Anticonvulsants; D010634:Phenobarbital