title: Measurement of the hepatitis B core-related antigen is valuable for predicting the pathological status of liver tissues in chronic hepatitis B patients.
abstract: The objective of this study was to evaluate the validities of serum hepatitis B core-related antigen (HBcrAg) for predicting the pathological status of liver tissues of chronic hepatitis B (CHB). A total of 205 Chinese patients with CHB, including 121 HBeAg-positive and 84 HBeAg-negative patients, were enrolled in this study. In HBeAg-positive patients, AUCs of serum HBcrAg for predicting severe necro-inflammation and advanced fibrosis were greater than 0.70; using serum HBcrAg<=4.81×10(4)kUmL(-1) and <=2.45×10(4)kUmL(-1) as cutoffs, the sensitivities, specificities, accuracies for predicting severe necro-inflammation and advanced fbrosis were 0.697, 0.716, 0.711 and 0.818, 0.778, 0.785, respectively. In HBeAg-negative patients, the AUCs of serum HBcrAg for predicting significant necro-inflammation and significant fibrosis were greater than 0.70; using serum HBcrAg>=1.70×10(2)kUmL(-1) and >=4.02kUmL(-1) as cutoffs, the sensitivities, specificities, accuracies for predicting significant necro-inflammation and significant fibrosis were 0.929, 0.964, 0.952 and 1.000, 1.000, 1.000, respectively. These results indicated favorable performances of serum HBcrAg for predicting severe necro-inflammation and advanced fibrosis in HBeAg-positive patients and significant necro-inflammation and significant fibrosis in negative patients.
authors.affiliation: Department of Hepatology, Shanghai Public Health Clinical Center of Fudan University, 2901 Caolang Road, Shanghai 201508, China. Electronic address: doctorzzqsphc@163.com.
authors.forename: Zhan-Qing
authors.initials: ZQ
authors.lastname: Zhang
authors.affiliation: Department of Hepatology, Shanghai Public Health Clinical Center of Fudan University, 2901 Caolang Road, Shanghai 201508, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Hepatology, Shanghai Public Health Clinical Center of Fudan University, 2901 Caolang Road, Shanghai 201508, China.
authors.forename: Yan-Bing
authors.initials: YB
authors.lastname: Wang
authors.affiliation: Shanghai Representative Office of Fujirebio Inc., 85 Loushanguan Road, Shanghai 200336, China.
authors.forename: Qi-Cheng
authors.initials: QC
authors.lastname: Weng
authors.affiliation: Shanghai Representative Office of Fujirebio Inc., 85 Loushanguan Road, Shanghai 200336, China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Zhang
authors.affiliation: Shanghai Representative Office of Fujirebio Inc., 85 Loushanguan Road, Shanghai 200336, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Yang
authors.affiliation: Department of Clinical Pathology, Shanghai Public Health Clinical Center of Fudan University, 2901 Caolang Road, Shanghai 201508, China.
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Feng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006512:Hepatitis B Core Antigens / Q000097:blood* / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000276:immunology / Q000473:pathology* / Q000821:virology; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000821:virology; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D006512:Hepatitis B Core Antigens
keywords: Hepatitis B core-related antigen; Noninvasive diagnosis; Pathological grade; Pathological stage