title: MicroRNAs and Their Impact on Radiotherapy for Cancer.
abstract: Resistance to radiation is considered to be an important reason for local failure after radiotherapy and tumor recurrence. However, the exact mechanisms of tumor resistance remain poorly understood. Current investigations of microRNAs as potential diagnostic and therapeutic tools for cancer treatment have shown promising results. With respect to radiotherapy resistance and response, there is now emerging evidence that microRNAs modulate key cellular pathways that mediate response to radiation. These data suggest that microRNAs might have significant potential as targets for the development of new therapeutic strategies to overcome radioresistance in cancer. This review summarizes the current literature pertinent to the influence of microRNAs in the response to radiotherapy for cancer treatment, with an emphasis on microRNAs as novel diagnostic and prognostic markers, as well as their potential to alter radiosensitivity.
authors.affiliation: a   University Hospital of Muenster, 48149 Muenster, Germany;
authors.forename: Ann-Kathrin
authors.initials: AK
authors.lastname: Mueller
authors.affiliation: a   University Hospital of Muenster, 48149 Muenster, Germany;
authors.forename: Kirsten
authors.initials: K
authors.lastname: Lindner
authors.affiliation: a   University Hospital of Muenster, 48149 Muenster, Germany;
authors.forename: Richard
authors.initials: R
authors.lastname: Hummel
authors.affiliation: b   Comprehensive Cancer Centre Muenster, University of Muenster, 48149 Muenster, Germany; and.
authors.forename: Jörg
authors.initials: J
authors.lastname: Haier
authors.affiliation: c   Flinders Medical Centre, Bedfork Park SA 5042, Australia.
authors.forename: David I
authors.initials: DI
authors.lastname: Watson
authors.affiliation: c   Flinders Medical Centre, Bedfork Park SA 5042, Australia.
authors.forename: Damian J
authors.initials: DJ
authors.lastname: Hussey
mesh_terms: D000818:Animals; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy*; D011836:Radiation Tolerance / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D035683:MicroRNAs