title: Metabolic syndrome and osteoporotic fracture: a population-based study in China.
abstract: BACKGROUND
  Associations between metabolic syndrome (MetS) and osteoporotic fracture have been reported. However, the epidemiological studies are not conclusive. The objective of the study was to determine whether metabolic syndrome associates with osteoporotic fracture.
  
  
  METHODS
  This was a cross-sectional study of 9930 Chinese adults aged 40 year or older in the Chongming District, Shanghai, China. A questionnaire, anthropometric measurements and laboratory tests were conducted. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. A history of fractures was collected with an interviewer-assisted questionnaire. Osteoporotic fractures were defined as fractures that occurred due to low-trauma in 2 years prior to the study.
  
  
  RESULTS
  Among women, the prevalence of osteoporotic fractures was significantly higher in those with MetS (3.5 vs. 2.6 %, P =0.028). However, the difference was not found in men (2.6 vs. 2.4 %, P =0.737). The presence of Mets was significantly associated with increased odds of osteoporotic fracture among women (odds ratio 1.22; 95 % confidence interval 1.12-1.54; P = 0.039) after controlling for potential confounders. The significant associations were not detected in men.
  
  
  CONCLUSIONS
  The presence of MetS was significantly associated with a recent history of osteoporotic fracture in middle-aged and elderly Chinese women.
authors.affiliation: Department of Endocrinology, Xinhua hospital Chongming branch, School of medicine, Shanghai Jiaotong University, 25 Nanmen Road, Shanghai, China.|Department of Endocrinology, Xinhua hospital, School of medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Qin
authors.affiliation: Department of Endocrinology, Xinhua hospital Chongming branch, School of medicine, Shanghai Jiaotong University, 25 Nanmen Road, Shanghai, China. yangzhen1020@hotmail.com.|Department of Endocrinology, Xinhua hospital, School of medicine, Shanghai Jiaotong University, Shanghai, China. yangzhen1020@hotmail.com.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, Xinhua hospital, School of medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Xinhua hospital Chongming branch, School of medicine, Shanghai Jiaotong University, 25 Nanmen Road, Shanghai, China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Gu
authors.affiliation: Department of Endocrinology, Xinhua hospital, School of medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Xinhua hospital, School of medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Lingfei
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Endocrinology, Xinhua hospital Chongming branch, School of medicine, Shanghai Jiaotong University, 25 Nanmen Road, Shanghai, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Lu
authors.affiliation: Department of Endocrinology, Xinhua hospital Chongming branch, School of medicine, Shanghai Jiaotong University, 25 Nanmen Road, Shanghai, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Department of Endocrinology, Xinhua hospital, School of medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Xinhua hospital, School of medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Niu
authors.affiliation: Department of Endocrinology, Ruijin hospital, School of medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
authors.affiliation: Department of Endocrinology, Xinhua hospital Chongming branch, School of medicine, Shanghai Jiaotong University, 25 Nanmen Road, Shanghai, China. suqingxinhua@163.com.|Department of Endocrinology, Xinhua hospital, School of medicine, Shanghai Jiaotong University, Shanghai, China. suqingxinhua@163.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Su
mesh_terms: D001794:Blood Pressure; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D058866:Osteoporotic Fractures / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides
keywords: Central obesity; Metabolic syndrome; Osteoporotic fractures