title: Management of Acute Kidney Injury and Acid-Base Balance in the Septic Patient.
abstract: Acute kidney injury (AKI) is an abrupt decrease in kidney function that takes place over hours to days. Sepsis is the leading cause of AKI and portends a particularly high morbidity and mortality, although the severity may vary from a transient rise in serum creatinine to end-stage renal disease. With regard to acid-base management in septic AKI, caution should be used with hyperchloremic crystalloid solutions, and dialysis is often used in the setting of severe acidosis. In the future, biomarkers may help clinicians identify AKI earlier and allow for potential interventions before the development of severe AKI.
authors.affiliation: Division of Critical Care, Department of Anesthesia, Columbia University, 630 West, 160th Street, New York, NY 10032, USA.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Weyker
authors.affiliation: Intensive Care Medicine, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona 08907, Spain.
authors.forename: Xosé L
authors.initials: XL
authors.lastname: Pérez
authors.affiliation: Division of Critical Care Medicine, Department of Anesthesia, University of California, San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address: Kathleen.liu@ucsf.edu.
authors.forename: Kathleen D
authors.initials: KD
authors.lastname: Liu
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology*; D058186:Acute Kidney Injury / Q000628:therapy*; D015415:Biomarkers / Q000097:blood*; D006801:Humans; D017582:Renal Replacement Therapy / Q000379:methods*; D018805:Sepsis / Q000150:complications*
chemical_list: D015415:Biomarkers
keywords: Acid-base; Acute kidney injury; Acute renal failure; Biomarkers; Renal replacement therapy; Sepsis