title: Light responsive hybrid nanofibres for on-demand therapeutic drug and cell delivery.
abstract: Smart materials for on-demand delivery of therapeutically active agents are challenging in pharmaceutical and biomaterials science. In the present study, we report hybrid nanofibres capable of being reversibly controlled to pulsatile deliver both therapeutic drugs and cells on-demand of near-infrared (NIR) light. The nanofibres, fabricated by co-electrospinning of poly (N-isopropylacrylamide), silica-coated gold nanorods and polyhedral oligomeric silsesquinoxanes have, for the first time, demonstrated rapid, reversible large-volume changes of 83% on-demand with NIR stimulation, with retained nanofibrous morphology. Combining with the extracellular matrix-mimicking fibrillary properties, the nanofibres achieved accelerated release of model drug or cells on demand with NIR triggering. The release of the model drug doxorubicin demonstrated normal anti-cancer efficacy by reducing the viability of human cervical cancer HeLa cells by 97% in 48 h. In parallel, the fibres allowed model cell NIH3T3 fibroblast entrapment, adhesion, proliferation, differentiation and, upon NIR irradiation, cell release with undisturbed cellular function. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.|Institute of Nanoscience and Nanotechnology, Central China Normal University, Wuhan, China.
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Li
authors.affiliation: Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Slemming-Adamsen
authors.affiliation: National Centre for Nanoscience and Technology, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
authors.forename: Jie
authors.initials: J
authors.lastname: Song
authors.affiliation: Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
authors.forename: Xueqin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Institute of Nanoscience and Nanotechnology, Central China Normal University, Wuhan, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
authors.forename: Mingdong
authors.initials: M
authors.lastname: Dong
authors.affiliation: National Centre for Nanoscience and Technology, Beijing, China.
authors.forename: Chunying
authors.initials: C
authors.lastname: Chen
authors.affiliation: Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
authors.forename: Flemming
authors.initials: F
authors.lastname: Besenbacher
authors.affiliation: Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.
authors.forename: Menglin
authors.initials: M
authors.lastname: Chen
mesh_terms: D000818:Animals; D017690:Cell Transplantation / Q000379:methods*; D018914:Cells, Immobilized / Q000378:metabolism / Q000637:transplantation*; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004317:Doxorubicin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D051379:Mice; D041681:NIH 3T3 Cells; D057139:Nanofibers / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004317:Doxorubicin
keywords: cell delivery; drug release; light responsive; nanofibres; on-demand