title: The Role of microRNAs in Animal Cell Reprogramming.
abstract: Our concept of cell reprogramming and cell plasticity has evolved since John Gurdon transferred the nucleus of a completely differentiated cell into an enucleated Xenopus laevis egg, thereby generating embryos that developed into tadpoles. More recently, induced expression of transcription factors, oct4, sox2, klf4, and c-myc has evidenced the plasticity of the genome to change the expression program and cell phenotype by driving differentiated cells to the pluripotent state. Beyond these milestone achievements, research in artificial cell reprogramming has been focused on other molecules that are different than transcription factors. Among the candidate molecules, microRNAs (miRNAs) stand out due to their potential to control the levels of proteins that are involved in cellular processes such as self-renewal, proliferation, and differentiation. Here, we review the role of miRNAs in the maintenance and differentiation of mesenchymal stem cells, epimorphic regeneration, and somatic cell reprogramming to induced pluripotent stem cells.
authors.affiliation: 1 Molecular and Developmental Complexity Group, Unidad de Genómica Avanzada (U.G.A.-LANGEBIO) CINVESTAV , Irapuato, México.
authors.forename: María Concepción
authors.initials: MC
authors.lastname: Cruz-Santos
authors.affiliation: 1 Molecular and Developmental Complexity Group, Unidad de Genómica Avanzada (U.G.A.-LANGEBIO) CINVESTAV , Irapuato, México.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Aragón-Raygoza
authors.affiliation: 1 Molecular and Developmental Complexity Group, Unidad de Genómica Avanzada (U.G.A.-LANGEBIO) CINVESTAV , Irapuato, México.
authors.forename: Annie
authors.initials: A
authors.lastname: Espinal-Centeno
authors.affiliation: 2 Laboratory of Epigenetics and Developmental Biology, Institute for Biotechnology and Applied Ecology (INBIOTECA) , Universidad Veracruzana, Xalapa, México.
authors.forename: Mario
authors.initials: M
authors.lastname: Arteaga-Vázquez
authors.affiliation: 3 Facultad of Chemistry, Autonomous University of Querétaro, Santiago de Querétaro, México.
authors.forename: Andrés
authors.initials: A
authors.lastname: Cruz-Hernández
authors.affiliation: 4 Department of Plant Physiology, Umeå University , Umeå, Sweden .
authors.forename: Laszlo
authors.initials: L
authors.lastname: Bako
authors.affiliation: 1 Molecular and Developmental Complexity Group, Unidad de Genómica Avanzada (U.G.A.-LANGEBIO) CINVESTAV , Irapuato, México.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Cruz-Ramírez
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D000066670:Cell Plasticity / Q000235:genetics; D065150:Cellular Reprogramming / Q000235:genetics*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000473:pathology
chemical_list: D035683:MicroRNAs