title: Modulation of T Cell Activation in Obesity.
abstract: Immune T cells are present in adipose tissues (AT), and the stoichiometry of the different T cell subsets is altered during diet-induced obesity (DIO). T cells contribute to the early steps of AT inflammation during DIO. Recent Advances: Many factors could potentially be responsible for this altered pro-inflammatory versus anti-inflammatory T cell balance.
  
  
  
  T cells are potentially activated in AT, which vitamin D might contribute to, as will be discussed in this article. In addition, we will review the different possible contributors to T cell activation in AT, such as the CD28 and CD154 T cell costimulatory molecules in AT.
  
  
  
  The potential antigen presentation capacities of adipocytes should be further investigated. Moreover, the properties of these AT resident (or migrating to AT) T cells must be further assessed. Antioxid. Redox Signal. 26, 489-500.
authors.affiliation: 1 Inserm, U1068, Centre de Recherche en Cancérologie de Marseille , Marseille, France .|2 Institut Paoli-Calmettes , Marseille, France .|3 CNRS, UMR7258, Centre de Recherche en Cancérologie de Marseille , Marseille, France .|4 Aix-Marseille Université , UM105, Marseille, France .
authors.forename: Stéphanie O
authors.initials: SO
authors.lastname: Morin
authors.affiliation: 5 Inserm U1062 , Marseille, France .|6 Inra , UMR1260, Marseille, France .|7 Aix-Marseille Université , Nutrition Obésité Risques Thrombotiques, Marseille, France .
authors.forename: Marjorie
authors.initials: M
authors.lastname: Poggi
authors.affiliation: 5 Inserm U1062 , Marseille, France .|6 Inra , UMR1260, Marseille, France .|7 Aix-Marseille Université , Nutrition Obésité Risques Thrombotiques, Marseille, France .
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Alessi
authors.affiliation: 5 Inserm U1062 , Marseille, France .|6 Inra , UMR1260, Marseille, France .|7 Aix-Marseille Université , Nutrition Obésité Risques Thrombotiques, Marseille, France .
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Landrier
authors.affiliation: 1 Inserm, U1068, Centre de Recherche en Cancérologie de Marseille , Marseille, France .|2 Institut Paoli-Calmettes , Marseille, France .|3 CNRS, UMR7258, Centre de Recherche en Cancérologie de Marseille , Marseille, France .|4 Aix-Marseille Université , UM105, Marseille, France .
authors.forename: Jacques A
authors.initials: JA
authors.lastname: Nunès
mesh_terms: D000818:Animals; D015415:Biomarkers; D002450:Cell Communication; D002454:Cell Differentiation / Q000187:drug effects; D006801:Humans; D056747:Immunomodulation; D007249:Inflammation / Q000150:complications / Q000276:immunology / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D009765:Obesity / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism
chemical_list: D015415:Biomarkers; D014157:Transcription Factors; D014807:Vitamin D
keywords: CD28; T cells; costimulation; high fat diet; liver steatosis