title: Relationship between Proton Magnetic Resonance Spectroscopy of Frontoinsular Gray Matter and Neurodevelopmental Outcomes in Very Low Birth Weight Children at the Age of 4.
abstract: Very low birth weight is associated with long term neurodevelopmental complications. Macroscopic brain abnormalities in prematurity survivors have been investigated in several studies. However, there is limited data regarding local cerebral metabolic status and neurodevelopmental outcomes. The purpose of this study was to characterize the relationship between proton magnetic resonance spectra in basal ganglia, frontal white matter and frontoinsular gray matter, neurodevelopmental outcomes assessed with the Leiter scale and the Developmental Test of Visual Perception and selected socioeconomic variables in a cohort of very low birth weight children at the age of four. Children were divided in three groups based on the severity of neurodevelopmental impairment. There were no differences in spectroscopy in basal ganglia and frontal white matter between the groups. Lower concentrations of N-acetylaspartate (NAA), choline (Cho) and myoinositol (mI) were observed in the frontoinsular cortex of the left hemisphere in children with neurodevelopmental impairment compared to children with normal neurodevelopmental outcomes. Higher parental education, daycare attendance and breastfeeding after birth were associated with more favorable neurodevelopmental prognosis, whereas rural residence was more prevalent in children with moderate and severe impairment. Our study demonstrates the role of long term neurometabolic disruption in the left frontoinsular cortex and selected socioeconomic variables in determination of neurodevelopmental prognosis in prematurity survivors.
authors.affiliation: Department of Pediatrics, Jagiellonian University, Wielicka 265, 30-663 Cracow, Poland.
authors.forename: Wojciech
authors.identifier: 0000-0002-6236-493X
authors.initials: W
authors.lastname: Durlak
authors.affiliation: Department of Electroradiology, Jagiellonian University, Michalowskiego 12, 31-126 Cracow, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Herman-Sucharska
authors.affiliation: Department of Radiology, Jagiellonian University, Kopernika 19, 31-501 Krakow, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Urbanik
authors.affiliation: Department of Pediatrics, Jagiellonian University, Wielicka 265, 30-663 Cracow, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Klimek
authors.affiliation: Department of Electroradiology, Jagiellonian University, Michalowskiego 12, 31-126 Cracow, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Karcz
authors.affiliation: Department of Applied Psychology and Human Development, Jagiellonian University, Wielicka 265, 30-663 Cracow, Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Dutkowska
authors.affiliation: Department of Applied Psychology and Human Development, Jagiellonian University, Wielicka 265, 30-663 Cracow, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Nitecka
authors.affiliation: Department of Pediatrics, Jagiellonian University, Wielicka 265, 30-663 Cracow, Poland.
authors.forename: Przemko
authors.initials: P
authors.lastname: Kwinta
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D002675:Child, Preschool; D002794:Choline / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007294:Inositol / Q000378:metabolism*; D008297:Male; D065886:Neurodevelopmental Disorders / Q000000981:diagnostic imaging / Q000378:metabolism; D066244:Proton Magnetic Resonance Spectroscopy; D012307:Risk Factors; D012959:Socioeconomic Factors
chemical_list: D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D002794:Choline