title: Nanoscale drug delivery for targeted chemotherapy.
abstract: Despite significant improvements in diagnostic methods and innovations in therapies for specific cancers, effective treatments for neoplastic diseases still represent major challenges. Nanotechnology as an emerging technology has been widely used in many fields and also provides a new opportunity for the targeted delivery of cancer drugs. Nanoscale delivery of chemotherapy drugs to the tumor site is highly desirable. Recent studies have shown that nanoscale drug delivery systems not only have the ability to destroy cancer cells but may also be carriers for chemotherapy drugs. Some studies have demonstrated that delivery of chemotherapy via nanoscale carriers has greater therapeutic benefit than either treatment modality alone. In this review, novel approaches to nanoscale delivery of chemotherapy are described and recent progress in this field is discussed.
authors.affiliation: Department of Radiotherapy, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xin
authors.affiliation: Major of Oncology, Xuzhou Medical University, Xuzhou, Jiangsu 221002, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, China.
authors.forename: Jian-Qin
authors.initials: JQ
authors.lastname: Tang
authors.affiliation: Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, China.
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Hou
authors.affiliation: Major of Oncology, Xuzhou Medical University, Xuzhou, Jiangsu 221002, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Radiotherapy, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, China.
authors.forename: Long Zhen
authors.initials: LZ
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, China. Electronic address: dr.guanjiang@gmail.com.
authors.forename: Guan
authors.initials: G
authors.lastname: Jiang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers
keywords: Cancer therapy; Chemotherapy; Drug delivery system; Nanotechnology