title: DYT1 dystonia increases risk taking in humans.
abstract: It has been difficult to link synaptic modification to overt behavioral changes. Rodent models of DYT1 dystonia, a motor disorder caused by a single gene mutation, demonstrate increased long-term potentiation and decreased long-term depression in corticostriatal synapses. Computationally, such asymmetric learning predicts risk taking in probabilistic tasks. Here we demonstrate abnormal risk taking in DYT1 dystonia patients, which is correlated with disease severity, thereby supporting striatal plasticity in shaping choice behavior in humans.
authors.affiliation: Department of Neurology, Hadassah Medical Center and the Hebrew University, Jerusalem, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Arkadir
authors.affiliation: Department of Psychology, Princeton University, Princeton, United States.|Princeton Neuroscience Institute, Princeton University, Princeton, United States.
authors.forename: Angela
authors.initials: A
authors.lastname: Radulescu
authors.affiliation: Department of Neurology, Beth Israel Medical Center, New York, United States.
authors.forename: Deborah
authors.initials: D
authors.lastname: Raymond
authors.affiliation: Department of Neurology, Beth Israel Medical Center, New York, United States.
authors.forename: Naomi
authors.initials: N
authors.lastname: Lubarr
authors.affiliation: Department of Neurology, Beth Israel Medical Center, New York, United States.
authors.forename: Susan B
authors.initials: SB
authors.lastname: Bressman
authors.affiliation: The Neurological Institute, Columbia University, New York, United States.
authors.forename: Pietro
authors.initials: P
authors.lastname: Mazzoni
authors.affiliation: Department of Psychology, Princeton University, Princeton, United States.|Princeton Neuroscience Institute, Princeton University, Princeton, United States.
authors.forename: Yael
authors.identifier: 0000-0002-0259-8371
authors.initials: Y
authors.lastname: Niv
mesh_terms: D004421:Dystonia / Q000235:genetics* / Q000523:psychology*; D006801:Humans; D018832:Molecular Chaperones / Q000235:genetics*; D012309:Risk-Taking
chemical_list: D018832:Molecular Chaperones; C108175:TOR1A protein, human
keywords: dystonia; human; neuroscience; reinforcement learning; risk aversion