title: Malignant pleural mesothelioma: initial experience in integrated (18)F-FDG PET/MR imaging.
abstract: OBJECTIVE
  This study aims to compare staging results of (18)F-FDG PET/computed tomography (CT) and integrated PET/magnetic resonance (MR) in malignant pleural mesothelioma (MPM) patients and to investigate a potential apparent diffusion coefficient (ADC)/SUV correlation.
  
  
  METHODS
  Six patients with MPM underwent (18)F-FDG PET/CT and PET/MR including diffusion-weighted imaging. Thoracic TNM staging was performed for both modalities. SUV and ADC were assessed in therapy-naive pleural lesions.
  
  
  RESULTS
  In thoracic TNM staging, no differences were found between PET/CT and PET/MR. An inverse correlation was observed between SUVmean and ADCmin (r=-0.63, P=.002).
  
  
  CONCLUSIONS
  MPM can be staged using PET/MR. The inverse correlation ADC/SUV indicates that future research on multiparametric therapy response evaluation may be warranted.
authors.affiliation: University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225 Dusseldorf, Germany; University Duisburg-Essen, Medical Faculty, Department of Diagnostic and Interventional Radiology and Neuroradiology, D-45147 Essen, Germany. Electronic address: Benedikt.Schaarschmidt@med.uni-duesseldorf.de.
authors.forename: Benedikt M
authors.initials: BM
authors.lastname: Schaarschmidt
authors.affiliation: University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225 Dusseldorf, Germany.
authors.forename: Lino M
authors.initials: LM
authors.lastname: Sawicki
authors.affiliation: University Duisburg-Essen, Medical Faculty, Department of Nuclear Medicine, D-45147 Essen, Germany.
authors.forename: Benedikt
authors.initials: B
authors.lastname: Gomez
authors.affiliation: University Duisburg-Essen, Medical Faculty, Department of Diagnostic and Interventional Radiology and Neuroradiology, D-45147 Essen, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Grueneisen
authors.affiliation: University Duisburg-Essen, Medical Faculty, Department of Medical Oncology, Essen, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Hoiczyk
authors.affiliation: University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225 Dusseldorf, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Heusch
authors.affiliation: University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225 Dusseldorf, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Buchbender
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D000086002:Mesothelioma, Malignant; D064847:Multimodal Imaging; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography; D011237:Predictive Value of Tests
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: DWI; MPM; Mesothelioma; PET/CT; PET/MR; PET/MRI