title: Linking up at the BAR: Oligomerization and F-BAR protein function.
abstract: As cells grow, move, and divide, they must reorganize and rearrange their membranes and cytoskeleton. The F-BAR protein family links cellular membranes with actin cytoskeletal rearrangements in processes including endocytosis, cytokinesis, and cell motility. Here we review emerging information on mechanisms of F-BAR domain oligomerization and membrane binding, and how these activities are coordinated with additional domains to accomplish scaffolding and signaling functions.
authors.affiliation: a Department of Cell and Developmental Biology , Vanderbilt University , Nashville , TN , USA.
authors.forename: Nathan A
authors.initials: NA
authors.lastname: McDonald
authors.affiliation: a Department of Cell and Developmental Biology , Vanderbilt University , Nashville , TN , USA.
authors.forename: Kathleen L
authors.initials: KL
authors.lastname: Gould
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D055503:Protein Multimerization; D017434:Protein Structure, Tertiary; D015398:Signal Transduction
chemical_list: D002352:Carrier Proteins
keywords: F-BAR domain; actin cytoskeleton; cell motility; cytokinesis; endocytosis; membrane bending; membrane binding; oligomerization; scaffolding; signaling; tubulation