title: Mesenchymal Stem Cells in Lipogems, a Reverse Story: from Clinical Practice to Basic Science.
abstract: The idea that basic science should be the starting point for modern clinical approaches has been consolidated over the years, and emerged as the cornerstone of Molecular Medicine. Nevertheless, there is increasing concern over the low efficiency and inherent costs related to the translation of achievements from the bench to the bedside. These burdens are also perceived with respect to the effectiveness of translating basic discoveries in stem cell biology to the newly developing field of advanced cell therapy or Regenerative Medicine. As an alternative paradigm, past and recent history in Medical Science provides remarkable reverse stories in which clinical observations at the patient's bedside have fed major advances in basic research which, in turn, led to consistent progression in clinical practice. Within this context, we discuss our recently developed method and device, which forms the core of a system (Lipogems) for processing of human adipose tissue solely with the aid of mild mechanical forces to yield a microfractured tissue product.
authors.affiliation: Istituto Image, Milan, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Tremolada
authors.affiliation: Cell Transplant Program and Diabetes Research Institute, University of Miami, Miami, FL, USA.
authors.forename: Camillo
authors.initials: C
authors.lastname: Ricordi
authors.affiliation: Skeletal Research Center, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Arnold I
authors.initials: AI
authors.lastname: Caplan
authors.affiliation: SWITH (Stem Wave Institute for Tissue Healing), Gruppo Villa Maria (GVM) and Ettore Sansavini Health Science Foundation - ONLUS, Lugo (Ravenna), Italy. carlo.ventura@unibo.it.|National Institute of Biostructures and Biosystems (NIBB) at the S. Orsola - Malpighi Hospital, Institute of Cardiology, University of Bologna, Pavilion 21, Via Massarenti N. 9, 40138, Bologna, Italy. carlo.ventura@unibo.it.
authors.forename: Carlo
authors.initials: C
authors.lastname: Ventura
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D002469:Cell Separation / Q000295:instrumentation / Q000379:methods*; D015925:Cryopreservation; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D013314:Stress, Mechanical; D057170:Translational Research, Biomedical
keywords: Adipose tissue; Adipose-derived stem cells; Chemical agents; Cryopreservation; Electromagnetic energy; Innovative device; Lipogems; Stromal vascular niche