title: Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease.
abstract: Immune dysfunction, promoted by pro-inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease.
  
  
  
  The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease.
  
  
  
  The experimental R6/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated.
  
  
  
  The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6/2 Huntington's disease mice, by immune dysfunction modulation in brain.
  
  
  
  This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.
authors.affiliation: Department of Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Luca
authors.affiliation: Department of Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Bellezza
authors.affiliation: Department of Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: Iva
authors.initials: I
authors.lastname: Arato
authors.affiliation: IRCCS Neuromed, Pozzilli, Italy.
authors.forename: Alba
authors.initials: A
authors.lastname: Di Pardo
authors.affiliation: Department of Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Mancuso
authors.affiliation: Department of Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Calvitti
authors.affiliation: Department of Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Falabella
authors.affiliation: Department of Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Bartoli
authors.affiliation: IRCCS Neuromed, Pozzilli, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Maglione
authors.affiliation: IRCCS Neuromed, Pozzilli, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Amico
authors.affiliation: IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Favellato
authors.affiliation: Department of Medicine, University of Perugia, Perugia, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Basta
authors.affiliation: Department of Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Bodo
authors.affiliation: Department of Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: Alba
authors.initials: A
authors.lastname: Minelli
authors.affiliation: Department of Medicine, University of Perugia, Perugia, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Calafiore
authors.affiliation: IRCCS Neuromed, Pozzilli, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Frati
authors.affiliation: IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Squitieri
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D003342:Corpus Striatum / Q000166:cytology; D051546:Cyclooxygenase 2 / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D004339:Drug Compounding / Q000379:methods*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D000071058:Huntingtin Protein / Q000235:genetics / Q000378:metabolism; D006816:Huntington Disease / Q000235:genetics / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009043:Motor Activity / Q000502:physiology; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D012708:Sertoli Cells / Q000502:physiology* / Q000637:transplantation*; D016019:Survival Analysis; D013552:Swine; D018911:Trinucleotide Repeats / Q000235:genetics
chemical_list: D016207:Cytokines; C086055:HTT protein, human; D000071058:Huntingtin Protein; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2
keywords: Cell transplant; Inflammation; Microcapsules; Motor performance