title: The Past, Present, and Future of Preimplantation Genetic Testing.
abstract: Preimplantation genetic testing (PGT) of oocytes and embryos is the earliest form of prenatal testing. PGT requires in vitro fertilization for embryo creation. In the past 25 years, the use of PGT has increased dramatically. The indications of PGT include identification of embryos harboring single-gene disorders, chromosomal structural abnormalities, chromosomal numeric abnormalities, and mitochondrial disorders; gender selection; and identifying unaffected, HLA-matched embryos to permit the creation of a savior sibling. PGT is not without risks, limitations, or ethical controversies. This review discusses the techniques and clinical applications of different forms of PGT and the debate surrounding its associated uncertainty and expanded use.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, University of South Florida Morsani College of Medicine, 2 Tampa General Circle, Suite 6022, Tampa, FL 33606, USA. Electronic address: aimudia@health.usf.edu.
authors.forename: Anthony N
authors.initials: AN
authors.lastname: Imudia
authors.affiliation: Division of Reproductive Endocrinology and Infertility, University of South Florida Morsani College of Medicine, 2 Tampa General Circle, Suite 6022, Tampa, FL 33606, USA.
authors.forename: Shayne
authors.initials: S
authors.lastname: Plosker
mesh_terms: D000782:Aneuploidy; D005260:Female; D030342:Genetic Diseases, Inborn / Q000175:diagnosis*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000266:history* / Q000379:methods / Q000639:trends
keywords: Aneuploidy; Embryo research; Preimplantation genetic diagnosis (PGD); Preimplantation genetic screening (PGS); Preimplantation genetic testing (PGT); Single-gene disorder