title: Expression of SOX18 in Mycosis Fungoides.
abstract: SOX18 is a transcription factor involved in the development of hair follicle, blood and lymphatic vessels, as well as regenerative processes. In addition, accumulated data indicate the role of SOX18 in tumourigenesis. So far, no studies on the role of SOX18 expression in mycosis fungoides (MF), the most common primary cutaneous T-cell lymphoma, have been performed. Therefore, we evaluated SOX18 expression in MF at the mRNA and protein level. SOX18 expression was observed predominantly on the blood and lymphatic vessels, in the intratumoural and peritumoural microenvironment of MF. The intra-tumoural, but not peritumoural, expression of SOX18 correlated positively with the advancement of the disease, cutaneous involvement and extracutaneous meta-stases at the protein level (p < 0.001, p < 0.001, p = 0.004; respectively). Significantly lower SOX18 mRNA expression was correlated with lymph node involvement (p = 0.01). In conclusion, we hypothesize that SOX18, as a marker of neovascularization, may be involved in the progression of MF.
authors.affiliation: Department of Dermatology, Venereology and Allergology, Medical University, Chalubinskiego 1, PL-50-368 Wrocław, Poland.
authors.forename: Alina
authors.initials: A
authors.lastname: Jankowska-Konsur
authors.forename: Christopher
authors.initials: C
authors.lastname: Kobierzycki
authors.forename: Adam
authors.initials: A
authors.lastname: Reich
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Piotrowska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Gomulkiewicz
authors.forename: Mateusz
authors.initials: M
authors.lastname: Olbromski
authors.forename: Marzena
authors.initials: M
authors.lastname: Podhorska-Okołów
authors.forename: Piotr
authors.initials: P
authors.lastname: Dzięgiel
authors.forename: Jacek C
authors.initials: JC
authors.lastname: Szepietowski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D015153:Blotting, Western; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000378:metabolism* / Q000473:pathology; D016133:Polymerase Chain Reaction; D055760:SOXF Transcription Factors / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C095473:SOX18 protein, human; D055760:SOXF Transcription Factors