title: Sarcoidosis and Autoimmunity: From Genetic Background to Environmental Factors.
abstract: Sarcoidosis is a chronic multisystem disease with variable course resulting from the interaction between environmental factors and the immune system of individuals genetically predisposed. The evidence linking sarcoidosis with environmental triggers such as metals is increasing. We describe the case of a 44 year old female with a history. of smoking since age 30 and previous mercury dental filling who presented at physical examination with numerous subcutaneous nodules. Laboratory data showed accelerated erythrocyte sedimentation rate and high titer of anti-U1 ribonucleoprotein antibodies (U1 RNP). Skin biopsy and chest X-ray suggested the diagnosis of sarcoidosis. In this report we illustrate the different causes involved in the onset of sarcoidosis.
authors.forename: Sara
authors.initials: S
authors.lastname: Bindoli
authors.forename: Amir
authors.initials: A
authors.lastname: Dagan
authors.forename: José J
authors.initials: JJ
authors.lastname: Torres-Ruiz
authors.forename: Carlo
authors.initials: C
authors.lastname: Perricone
authors.forename: Mojca
authors.initials: M
authors.lastname: Bizjak
authors.forename: Andrea
authors.initials: A
authors.lastname: Doria
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
mesh_terms: D000328:Adult; D001323:Autoantibodies; D015551:Autoimmunity / Q000235:genetics; D001799:Blood Sedimentation; D003723:Dental Amalgam / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010375:Pedigree; D012261:Ribonucleoproteins / Q000276:immunology*; D017565:Sarcoidosis, Pulmonary / Q000150:complications / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology; D012871:Skin Diseases / Q000175:diagnosis / Q000209:etiology; D012907:Smoking / Q000009:adverse effects
chemical_list: D001323:Autoantibodies; D012261:Ribonucleoproteins; D003723:Dental Amalgam