title: Lower sensitivity of serum (1,3)-β-d-glucan for the diagnosis of candidaemia due to Candida parapsilosis.
abstract: The aim of this study was to evaluate the sensitivity and the levels of 1,3-β-d-glucan (BDG) among patients with candidaemia due to different Candida species. Retrospective study of all patients who had a single-species candidaemia and BDG testing performed within 48 h from the onset of candidaemia during 2009-2015 was performed. Factors influencing the sensitivity of BDG, including the presence of a central venous catheter, antifungal therapy and Candida species, were analysed in univariate and multivariate models. In all, 107 patients with the following Candida distribution were included: 46 (43%) Candida albicans, 37 (35%) Candida parapsilosis, and 24 (22%) other species. BDG sensitivity and levels were the highest in C. albicans candidaemia and lowest for C. parapsilosis (respectively, 72% and 410 pg/mL for C. albicans, 41% and 39 pg/mL for C. parapsilosis, and 63% and 149 pg/mL for other species; p 0.015 and p 0.003). In multivariate analysis, Candida species (parapsilosis versus others) was the only factor influencing the sensitivity of BDG (OR 0.3, 95% CI 0.1-0.7, p 0.006). The sensitivity of BDG in candidaemia seems highly dependent on the fungal species, with the lowest being for C. parapsilosis.
authors.affiliation: Division of Infectious Diseases, Department of Health Sciences, University of Genoa, Genoa, Italy; Division of Infectious Diseases, IRCCS San Martino University Hospital-IST, Genoa, Italy. Electronic address: m.mikulska@unige.it.
authors.forename: M
authors.initials: M
authors.lastname: Mikulska
authors.affiliation: Division of Infectious Diseases, Department of Health Sciences, University of Genoa, Genoa, Italy; Division of Infectious Diseases, IRCCS San Martino University Hospital-IST, Genoa, Italy.
authors.forename: D R
authors.initials: DR
authors.lastname: Giacobbe
authors.affiliation: Division of Infectious Diseases, Department of Health Sciences, University of Genoa, Genoa, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Furfaro
authors.affiliation: Division of Infectious Diseases, Department of Health Sciences, University of Genoa, Genoa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Mesini
authors.affiliation: Microbiology Unit, University of Genoa (DISC) and IRCCS San Martino-IST, Genoa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Marchese
authors.affiliation: Division of Infectious Diseases, IRCCS San Martino University Hospital-IST, Genoa, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Del Bono
authors.affiliation: Division of Infectious Diseases, Department of Health Sciences, University of Genoa, Genoa, Italy; Division of Infectious Diseases, IRCCS San Martino University Hospital-IST, Genoa, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Viscoli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002175:Candida / Q000145:classification / Q000302:isolation & purification*; D058387:Candidemia / Q000175:diagnosis* / Q000382:microbiology*; D003955:Diagnostic Tests, Routine / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011509:Proteoglycans; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D044967:Serum / Q000737:chemistry*; D047071:beta-Glucans / Q000097:blood*
chemical_list: D011509:Proteoglycans; D047071:beta-Glucans; C010770:polysaccharide-K
keywords: Candida parapsilosis; Fungitell; Glucan; Non-albicans; Performance