title: The 2010-2015 Prevalence of Eosinophilic Esophagitis in the USA: A Population-Based Study.
abstract: Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder with increasing prevalence. However, epidemiologic data have mostly been acquired from small studies. We sought to describe the epidemiology of EoE in the USA, utilizing a large database.
  
  
  
  We queried a commercial database (Explorys Inc, Cleveland, OH, USA), an aggregate of electronic health record data from 26 major integrated US healthcare systems from 1999 to July 2015. We identified an aggregated patient cohort of eligible patients with EoE and a history of proton-pump inhibitor use between July 2010 and July 2015, based on Systematized Nomenclature of Medicine-Clinical Terms. We calculated the prevalence of EoE among different patient groups.
  
  
  
  Of the 30,301,440 individuals in the database, we identified 7840 patients with EoE with an overall prevalence of 25.9/100,000 persons. Prevalence was higher in males than females [odds ratio (OR) 2.00; 95 % CI 1.92-2.10, p < 0.0001], Caucasians versus African-Americans and Asians (OR 2.00; 95 % CI 1.86-2.14, p < 0.0001), and adults (18-65 years) versus elderly (>65 years) and children (<18 years) (OR 1.63; 95 % CI 1.54-1.71, p < 0.0001). Compared with controls (individuals in database without EoE), individuals with EoE were more likely to have other gastrointestinal diagnoses such as dysphagia and at least one allergic condition.
  
  
  
  In this large study, we found that the estimated prevalence of EoE in the USA is 25.9/100,000, which is at the lower end of prevalence rates reported in the USA and other industrial countries. We confirmed that EoE has a strong association with allergic and gastrointestinal diagnoses.
authors.affiliation: Department of Internal Medicine, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.
authors.forename: Emad
authors.initials: E
authors.lastname: Mansoor
authors.affiliation: Division of Gastroenterology and Liver Disease, Department of Internal Medicine, University Hospitals Case Medical Center, 11100 Euclid Avenue, Wearn 244, Cleveland, OH, 44106, USA. Gregory.Cooper@UHhospitals.org.
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Cooper
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D017677:Age Distribution; D000368:Aged; D001213:Asian / Q000706:statistics & numerical data; D001249:Asthma / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D015897:Comorbidity; D016208:Databases, Factual; D003680:Deglutition Disorders / Q000453:epidemiology; D003872:Dermatitis / Q000188:drug therapy / Q000453:epidemiology; D057765:Eosinophilic Esophagitis / Q000188:drug therapy / Q000453:epidemiology*; D005006:Ethnicity / Q000706:statistics & numerical data*; D005260:Female; D006633:Histamine Antagonists / Q000627:therapeutic use; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012220:Rhinitis / Q000188:drug therapy / Q000453:epidemiology; D017678:Sex Distribution; D012852:Sinusitis / Q000188:drug therapy / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D006633:Histamine Antagonists; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors
keywords: Eosinophilic esophagitis; Epidemiology; Prevalence