title: Prediction of preterm labor by a rapid bedside test detecting phosphorylated insulin-like growth factor-binding protein 1 in cervical secretions.
abstract: OBJECTIVE
  To evaluate the utility of measuring phosphorylated insulin-like growth factor-binding protein 1 (phIGFBP-1) in cervical secretions to predict preterm birth among women with premature uterine contractions.
  
  
  METHODS
  A prospective study was conducted between September 27, 2013, and February 28, 2014, at a tertiary center in India. Participants with symptoms of preterm labor at 24-36weeks underwent testing for phIGFBP-1 in cervical secretions. Cervical length was measured by ultrasonography.
  
  
  RESULTS
  Cervical swab samples tested positive for phIGFBP-1 among 34 (57%) of the 60 participants. Mean cervical length was 2.15±0.63cm among the 46 (77%) women who delivered preterm and 2.54±0.47cm among the 14 (23%) women who delivered at term. Of the 46 preterm deliveries, 29 (63%) women tested positive for phIGFBP-1 and 17 (37%) tested negative. Mean length of pregnancy at delivery was 32.11±4.09weeks and 35.77±1.68weeks among women who tested positive and negative for phIGFBP-1, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of phIGFBP-1 to predict preterm birth were 86.96%, 35.29%, 64.52%, and 66.67%, respectively.
  
  
  CONCLUSIONS
  A rapid bedside test measuring phIGFBP-1 identified women at high risk of preterm delivery.
authors.affiliation: Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India. Electronic address: drmanu_8@yahoo.co.in.
authors.forename: Manu
authors.initials: M
authors.lastname: Goyal
authors.affiliation: Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Alka
authors.initials: A
authors.lastname: Kriplani
authors.affiliation: Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Garima
authors.initials: G
authors.lastname: Kachhawa
authors.affiliation: Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Shreenivas
authors.initials: S
authors.lastname: Badiger
mesh_terms: D000328:Adult; D054791:Cervical Length Measurement; D005260:Female; D005865:Gestational Age; D006801:Humans; D007194:India; D007231:Infant, Newborn; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000032:analysis*; D000067716:Point-of-Care Testing; D011237:Predictive Value of Tests; D011247:Pregnancy; D047928:Premature Birth / Q000175:diagnosis*; D011446:Prospective Studies; D018570:Risk Assessment; D062606:Tertiary Care Centers; D014463:Ultrasonography; D055815:Young Adult
chemical_list: C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1
keywords: Cervical length; Maternal; Perinatal; Phosphorylated insulin-like growth factor-binding protein 1; Prediction; Preterm labor