title: Catalyst-controlled switch of regioselectivity in the asymmetric allylic alkylation of oxazolones with MBHCs.
abstract: A catalyst-controlled switch of regioselectivity in asymmetric allylic alkylation of oxazolones with MBHCs was described. The SN2'-SN2' reaction catalysed by a quinine-derived base produced γ-selective secondary allylic oxazolone derivatives, whereas the addition-elimination reaction catalysed by an amino acid-derived bifunctional urea catalyst provided β-selective primary adducts.
authors.affiliation: School of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P. R. China. sunws@lzu.edu.cn wangrui@lzu.edu.cn.
authors.forename: Gongming
authors.initials: G
authors.lastname: Zhu
authors.affiliation: School of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P. R. China. sunws@lzu.edu.cn wangrui@lzu.edu.cn.
authors.forename: Junxian
authors.initials: J
authors.lastname: Yang
authors.affiliation: School of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P. R. China. sunws@lzu.edu.cn wangrui@lzu.edu.cn.
authors.forename: Guangjun
authors.initials: G
authors.lastname: Bao
authors.affiliation: School of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P. R. China. sunws@lzu.edu.cn wangrui@lzu.edu.cn.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P. R. China. sunws@lzu.edu.cn wangrui@lzu.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P. R. China. sunws@lzu.edu.cn wangrui@lzu.edu.cn.
authors.forename: Yiping
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P. R. China. sunws@lzu.edu.cn wangrui@lzu.edu.cn.
authors.forename: Wangsheng
authors.initials: W
authors.lastname: Sun
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. hongliang@sysu.edu.cn.
authors.forename: Liang
authors.initials: L
authors.lastname: Hong
authors.affiliation: School of Life Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P. R. China. sunws@lzu.edu.cn wangrui@lzu.edu.cn and School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. hongliang@sysu.edu.cn.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang