title: Protection against vascular endothelial dysfunction by polyphenols in sea buckthorn berries in rats with hyperlipidemia.
abstract: Chronic hyperlipemia increases the incidence of vascular endothelial dysfunction and can even induce cardiovascular disease. Sea buckthorn contains a host of bioactives such as flavonoids and polyphenols that can prevent the development of cardiovascular disease. The current study isolated active ingredients, polyphenols, from sea buckthorn berries (SVP) and orally administered SVP at a dose of 7-28 mg/kg. This treatment significantly reduced serum lipids, it enhanced the activity of antioxidant enzymes, and it decreased the level of serum TNF-α and IL-6. SVP also alleviate vascular impairment by decreasing the expression of eNOS, ICAM-1, and LOX-1 mRNA and proteins in aortas of rats with hyperlipidemia. Based on these findings, SVP has antioxidant action and it protects endothelium.
authors.affiliation: Northwest Institute of Plateau Biology, Chinese Academy of Sciences.
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.forename: Yourui
authors.initials: Y
authors.lastname: Suo
authors.forename: Dongli
authors.initials: D
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Tong
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D005419:Flavonoids / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D005638:Fruit / Q000737:chemistry; D031281:Hippophae / Q000737:chemistry*; D006949:Hyperlipidemias / Q000188:drug therapy*; D015850:Interleukin-6 / Q000097:blood; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000737:chemistry; D059808:Polyphenols / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D020011:Protective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D015850:Interleukin-6; D008055:Lipids; D010936:Plant Extracts; D059808:Polyphenols; D020011:Protective Agents; D014409:Tumor Necrosis Factor-alpha