title: [Effect of Dexmedetomidine Combined Electrical Stimulation on Coanitive Function of Patients Receiving Extracerebral Intervention].
abstract: OBJECTIVE
  To explore the effect of dexmedetomidine combined electrical stimulation on cognitive function of neurosurgical diseases patients treated by extracerebral intervention.
  
  
  METHODS
  Totally 122 patients with neurosurgical diseases who underwent selective intervention were randomly assigned to the observation group and the control group, 61 cases in each group. Patients in the control group recieved anesthesia by dexmedetomidine. Those in the observation group received electrical stimulation at Baihui (DU20), Yintang ( EX-HN3), and Neiguan (PC6) before dexmedetomidine anesthesia. The cognitive function of patients at preoperative day 1 and postoperative day 1 was respectively evaluated by Mini-Mental State Examinations (MMSE). Serum NSE, S-100β, IL-1β, IL-6, and TNF-α levels were detected in the two groups before intervention and immediately after intervention using ELISA.
  
  
  RESULTS
  MMSE scores of two groups were significantly reduced at post-intervention day 1, as compared with one day before intervention. MMSE score of the observation group at post-intervention day 1 was (23.15 ± 1.87) points, significantly higher than that of the control group [ (19.34 ± 1.64) points , (P < 0.05)]. The postoperative cognitive dysfunction (POCD) incidence rate of the observation group was 16.4% (10/61), significantly lower than that of the control group [39.3% (24/61); P < 0.05]. Compared with before intervention, NSE and S-100β protein levels, IL-1β, IL-6 and α-TNF levels of the two groups increased (P < 0.05). Post-intervention NSE and S-100β protein levels, IL-1β, IL-6 and α-TNF levels were significantly lower in the observation group than in the control group (P < 0.05).
  
  
  CONCLUSIONS
  Dexmedetomidine combied electrical stimulation could effectively prevent the occurrence of postoperative cognition, and reduce levels of NSA, S-100β, IL-1β, IL-6 and TNF-α.
authors.forename: Jun
authors.initials: J
authors.lastname: Yuan
authors.forename: Yu
authors.initials: Y
authors.lastname: Wu
authors.forename: Ji-yong
authors.initials: JY
authors.lastname: Li
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Liu
authors.forename: Sheng-xiong
authors.initials: SX
authors.lastname: Tong
authors.forename: Fang-fang
authors.initials: FF
authors.lastname: Deng
mesh_terms: D015669:Acupuncture Points; D000758:Anesthesia / Q000379:methods*; D003071:Cognition; D003072:Cognition Disorders / Q000517:prevention & control*; D020927:Dexmedetomidine / Q000627:therapeutic use*; D004599:Electric Stimulation Therapy; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures; D010751:Phosphopyruvate Hydratase / Q000097:blood; D011183:Postoperative Complications; D011184:Postoperative Period; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: C508585:IL1B protein, human; C508600:IL6 protein, human; D053583:Interleukin-1beta; D015850:Interleukin-6; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D014409:Tumor Necrosis Factor-alpha; D020927:Dexmedetomidine; D010751:Phosphopyruvate Hydratase