title: Treatment not helpful in Alzheimer's.
abstract: Treatment with the cholinesterase inhibitor tacrine and lecithin does not improve the symptoms of Alzheimer'sdisease and may induce hepatitis, researchers say. Following a report of beneficialeffects they performed a multicentre double blind, placebo controlled, crossovertrial involving 67 patients given a meanof ll4mg tacrine or placebo daily plus1,200mg lecithin for four weeks. Cognitive, behavioural and overall state weremeasured using rating scales.