title: Effect of chronic morphine administration on circulating dendritic cells in SIV-infected rhesus macaques.
abstract: We studied the effect of chronic morphine administration on the circulating dendritic cell population dynamics associated with SIV infection using rhesus macaques. Animals were either first infected with SIV and then given chronic morphine, or visa versa. SIV infection increased the numbers of myeloid DCs (mDCs), but morphine treatment attenuated this mDC expansion. In contrast, morphine increased the numbers of plasmacytoid DCs (pDCs) in SIV-infected animals. Finally, chronic morphine administration (no SIV) transiently increased the numbers of circulating pDCs. These results show that chronic morphine induces a significant alteration in the available circulating levels of critical antigen-presenting cells.
authors.affiliation: Center for Inflammation, Translational and Clinical Lung Research, USA.
authors.forename: William D
authors.initials: WD
authors.lastname: Cornwell
authors.affiliation: BioQual Incorporated, 9600 Medical Center Dr., Rockville, MD 20850, USA.
authors.forename: Wendeline
authors.initials: W
authors.lastname: Wagner
authors.affiliation: BioQual Incorporated, 9600 Medical Center Dr., Rockville, MD 20850, USA.
authors.forename: Mark G
authors.initials: MG
authors.lastname: Lewis
authors.affiliation: Temple University Flow Cytometry Facility, USA.
authors.forename: Xiaoxuan
authors.initials: X
authors.lastname: Fan
authors.affiliation: Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA.
authors.forename: Jay
authors.initials: J
authors.lastname: Rappaport
authors.affiliation: Center for Inflammation, Translational and Clinical Lung Research, USA. Electronic address: rogerst@temple.edu.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Rogers
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002452:Cell Count; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000187:drug effects* / Q000378:metabolism; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005260:Female; D005434:Flow Cytometry; D015658:HIV Infections / Q000473:pathology* / Q000662:veterinary; D008253:Macaca mulatta; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D022423:Myeloid Cells / Q000187:drug effects / Q000378:metabolism; D009294:Narcotics / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D016207:Cytokines; D009294:Narcotics; D009020:Morphine
keywords: CD83; Dendritic cells; Morphine; Myeloid; Plasmacytoid; SIV