title: Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy.
abstract: Diabetic nephropathy (DN) is a serious microvascular complication that can lead to chronic and end-stage renal failure. It is understood that inflammation is associated with the onset and process of DN. Low molecular weight fucoidan (LMWF) isolated from Saccharina japonica has anti-inflammatory properties. Therefore, this study aimed to explore the mechanism of LMWF in DN model induced by streptozotocin. The biochemical indices levels showed LMWF reduced the DN diagnostic indices to protect renal function. The HE stained sections exhibited LMWF protected normal morphological structures and reduced inflammatory cell infiltration in the kidneys of DN rats. Furthermore, the levels of P-selectin and selectin-dependent inflammatory cytokines resulting from LMWF were obviously decreased at both the transcriptional and protein levels. Thus, our results found that LMWF protected the renal function in DN rats and alleviated inflammation through the modulation of P-selectin and inflammatory cytokines. LMWF may have therapeutic potential against DN.
authors.affiliation: Key Lab of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Lab for Marine Science and Technology. Qingdao 266071, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Key Lab of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Lab for Marine Science and Technology. Qingdao 266071, China; State Key Lab of Seaweed Bioactive Substances, Qingdao 266000, China. Electronic address: qbzhang@qdio.ac.cn.
authors.forename: Quanbin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, School of Chemical Biology & Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China.
authors.forename: Dali
authors.initials: D
authors.lastname: Luo
authors.affiliation: Key Lab of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Lab for Marine Science and Technology. Qingdao 266071, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Lab of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Lab for Marine Science and Technology. Qingdao 266071, China; State Key Lab of Seaweed Bioactive Substances, Qingdao 266000, China. Electronic address: dlduan@qdio.ac.cn.
authors.forename: Delin
authors.initials: D
authors.lastname: Duan
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D007795:Laminaria / Q000737:chemistry*; D008297:Male; D019007:P-Selectin / Q000378:metabolism*; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019007:P-Selectin; D011134:Polysaccharides; C007789:fucoidan
keywords: Diabetic nephropathy; Fucoidan; P-selectin