title: A Tubular Biomaterial Construct Exhibiting a Negative Poisson's Ratio.
abstract: Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has a negative Poisson's ratio νxy (NPR). NPR constructs have the unique ability to expand transversely when pulled axially, thereby resulting in a highly-compliant tubular construct. In this work, we used projection stereolithography to 3D-print a planar NPR sheet composed of photosensitive poly(ethylene) glycol diacrylate biomaterial. We used a step-lithography exposure and a stitch process to scale up the projection printing process, and used the cut-missing rib unit design to develop a centimeter-scale NPR sheet, which was rolled up to form a tubular construct. The constructs had Poisson's ratios of -0.6 ≤ νxy ≤ -0.1. The NPR construct also supports higher cellular adhesion than does the construct that has positive νxy. Our NPR design offers a significant advance in the development of highly-compliant vascular grafts.
authors.affiliation: Department of Molecular Medicine, School of Medicine, Gachon University, 7-45, Songdo-dong, Yeonsu-ku, Incheon, 406-840, Republic of Korea.
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Biomedical and Chemical Engineering, Syracuse University, 318 Browne Hall, Syracuse, NY, 13244, United States of America.
authors.forename: Pranav
authors.initials: P
authors.lastname: Soman
authors.affiliation: Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja dong, Nam-gu, Pohang, Gyeongbuk, 790-781, Republic of Korea.
authors.forename: Jeong Hun
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, Atkinson Hall, MC-0448, La Jolla, CA, 92093, United States of America.
authors.forename: Shaochen
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja dong, Nam-gu, Pohang, Gyeongbuk, 790-781, Republic of Korea.
authors.forename: Dong-Woo
authors.initials: DW
authors.lastname: Cho
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D020342:Finite Element Analysis; D006801:Humans; D055595:Mechanical Phenomena; D061848:Optical Imaging; D016012:Poisson Distribution; D011092:Polyethylene Glycols / Q000737:chemistry*; D066330:Printing, Three-Dimensional
chemical_list: D001672:Biocompatible Materials; C437167:poly(ethylene glycol)diacrylate; D011092:Polyethylene Glycols