title: Challenges Evaluating Chemotherapy-Induced Peripheral Neuropathy in Childhood Cancer Survivors.
abstract: Children treated for cancer are exposed to a variety of chemotherapeutic agents with known toxicity to the peripheral nervous system. The side effect of peripheral neuropathy can cause changes in sensation, function, and even cause pain. Although peripheral neuropathy is recognized by pediatric oncology nurses as an important and significant side effect, measuring neuropathy can be quite complex for clinical care and research efforts. With more children surviving a cancer diagnosis today, this issue is increasingly important for childhood cancer survivors. This article has reviewed existing literature examining peripheral neuropathy in childhood cancer survivors with particular interest paid to measurement tools available and needs for future research. It is important for nurses to choose appropriate measures for clinical care and research methods in order to have an impact on patients experiencing this condition.
authors.affiliation: 1 Washington University School of Medicine, Saint Louis, MO, USA.
authors.forename: Caroline
authors.initials: C
authors.lastname: Mohrmann
authors.affiliation: 2 University of Missouri, Columbia, MO, USA.
authors.forename: Jane
authors.initials: J
authors.lastname: Armer
authors.affiliation: 1 Washington University School of Medicine, Saint Louis, MO, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Hayashi
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D064420:Drug-Related Side Effects and Adverse Reactions / Q000188:drug therapy; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D020258:Neurotoxicity Syndromes / Q000209:etiology* / Q000517:prevention & control; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000517:prevention & control; D011788:Quality of Life; D012307:Risk Factors; D017741:Survivors
chemical_list: D000970:Antineoplastic Agents
keywords: childhood cancer survivors; late effects; peripheral neuropathy; peripheral neuropathy measurement