title: Total Synthesis of Millingtonine.
abstract: Millingtonine is a glycosidic alkaloid that exists as a pair of pseudo-enantiomeric diastereomers. Consideration of the likely biosynthetic origins of this unusual natural product has resulted in the development of a seven-step total synthesis. Results from this synthetic work provide evidence in support of a proposed network of biosynthetic pathways that can account for the formation of several phenylethanoid natural products.
authors.affiliation: EaStCHEM School of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, UK.
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Brown
authors.affiliation: EaStCHEM School of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, UK. a.lawrence@ed.ac.uk.
authors.forename: Andrew L
authors.identifier: 0000-0002-9573-5637
authors.initials: AL
authors.lastname: Lawrence
keywords: alkaloids; biomimetic synthesis; domino reactions; natural products; phenylethanoids