title: PEG stabilized DNA - poly(ferrocenylsilane) polyplexes for gene delivery.
abstract: Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.
authors.affiliation: Department of Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands. G.J.Vancso@utwente.nl.
authors.forename: B
authors.initials: B
authors.lastname: Zoetebier
authors.affiliation: Department of Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands. G.J.Vancso@utwente.nl and Department of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, P.O. Box 951600, Los Angeles, CA 90095, USA.
authors.forename: A
authors.initials: A
authors.lastname: Sohrabi
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands. W.E.Hennink@uu.nl.
authors.forename: B
authors.initials: B
authors.lastname: Lou
authors.affiliation: Department of Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands. G.J.Vancso@utwente.nl.
authors.forename: M A
authors.initials: MA
authors.lastname: Hempenius
authors.affiliation: Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, The Netherlands. W.E.Hennink@uu.nl.
authors.forename: W E
authors.initials: WE
authors.lastname: Hennink
authors.affiliation: Department of Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands. G.J.Vancso@utwente.nl.
authors.forename: G J
authors.initials: GJ
authors.lastname: Vancso
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000235:genetics*; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D005296:Ferrous Compounds / Q000737:chemistry*; D008422:Materials Testing; D011094:Polyethyleneimine / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D014162:Transfection
chemical_list: D004337:Drug Carriers; D005296:Ferrous Compounds; D012821:Silanes; C554070:poly(ferrocenylsilane); D011094:Polyethyleneimine; D004247:DNA