title: Effect of repetitive transcranial magnetic stimulation on auditory function following acoustic trauma.
abstract: Repetitive transcranial magnetic stimulation (rTMS) is one form of non-invasive brain stimulation and increasingly shows neuroprotection in multiple neurological disorders. However, the potential of rTMS for protective action on auditory function following acoustic trauma has not been investigated. Here, we examined effect of TMS on hearing conservation, neurons survival and brain-derived neurotrophin factor (BDNF) expression in the cochlea and auditory cortex following acoustic trauma in rats. Wistar rats were exposed to intense pure tone noise (10 kHz, 120 dB SPL for 2 h) followed by rTMS treatment or sham treatment (handling control) daily for 14 days. Auditory brainstem response revealed there was no significant difference in hearing threshold shifts between rTMS- and sham-treated rats, although rTMS-treated rats showed less neuron loss in the auditory cortex in comparison with sham rats. Additionally, acoustic trauma increased BDNF expression in the cochlea and auditory cortex, and this elevation could be attenuated by rTMS treatment. Our results suggest present regiment of rTMS does not protect hearing against acoustic trauma, but maybe have implications for tinnitus treatment.
authors.affiliation: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, China.|Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
authors.forename: Haidi
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, China.|Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Xiong
authors.affiliation: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, China.|Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
authors.forename: Yongkang
authors.initials: Y
authors.lastname: Ou
authors.affiliation: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, China.|Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
authors.forename: Yaodong
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, China.|Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Pang
authors.affiliation: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, China.|Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Lai
authors.affiliation: Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yan Jiang Road, Guangzhou, 510120, China. yiqingzheng@hotmail.com.|Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China. yiqingzheng@hotmail.com.
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001303:Auditory Cortex / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D003051:Cochlea / Q000378:metabolism*; D004195:Disease Models, Animal; D004569:Electroencephalography; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D006317:Hearing Loss, Noise-Induced / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D009622:Noise / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D050781:Transcranial Magnetic Stimulation / Q000379:methods*
chemical_list: D019208:Brain-Derived Neurotrophic Factor
keywords: Acoustic trauma; Auditory cortex; Brain-derived neurotrophic factor; Repetitive transcranial magnetic stimulation; Tinnitus