title: Transcriptional Dysregulation of Adipose Tissue Autophagy in Obesity.
abstract: There is growing interest in understanding how dysregulated autophagy may contribute to pathogenesis of disease. Most frequently, disease states are associated with diminished autophagy, mostly attributed to genetic variation in autophagy genes and/or to dysfunctional posttranscriptional mechanisms. In human adipose tissue (AT), in obesity, expression of autophagy genes is upregulated and autophagy is likely activated, associating with adipose dysfunction. This review explores the emerging role of transcriptional mechanisms regulating AT autophagy in obesity.
authors.affiliation: Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel;
authors.forename: Nitzan
authors.initials: N
authors.lastname: Maixner
authors.affiliation: Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel; the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel; and.
authors.forename: Sapir
authors.initials: S
authors.lastname: Bechor
authors.affiliation: the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel; and Department of Microbiology and Immunology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Zlata
authors.initials: Z
authors.lastname: Vershinin
authors.affiliation: Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel; the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel; and.
authors.forename: Tal
authors.initials: T
authors.lastname: Pecht
authors.affiliation: Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel;
authors.forename: Nir
authors.initials: N
authors.lastname: Goldstein
authors.affiliation: Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel;
authors.forename: Yulia
authors.initials: Y
authors.lastname: Haim
authors.affiliation: Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel; the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel; and rudich@bgu.ac.il.
authors.forename: Assaf
authors.initials: A
authors.lastname: Rudich
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001343:Autophagy; D002453:Cell Cycle; D006801:Humans; D051379:Mice; D009765:Obesity / Q000235:genetics* / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors