title: The Patient-Oriented Eczema Measure in young children: responsiveness and minimal clinically important difference.
abstract: The Patient-Oriented Eczema Measure (POEM) has been recommended as the core patient-reported outcome measure for trials of eczema treatments. Using data from the Choice of Moisturiser for Eczema Treatment randomized feasibility study, we assess the responsiveness to change and determine the minimal clinically important difference (MCID) of the POEM in young children with eczema.
  
  
  
  Responsiveness to change by repeated administrations of the POEM was investigated in relation to change recalled using the Parent Global Assessment (PGA) measure. Five methods of determining the MCID of the POEM were employed; three anchor-based methods using PGA as the anchor: the within-patient score change, between-patient score change and sensitivity and specificity method, and two distribution-based methods: effect size estimate and the one half standard deviation of the baseline distribution of POEM scores.
  
  
  
  Successive POEM scores were found to be responsive to change in eczema severity. The MCID of the POEM change score, in relation to a slight improvement in eczema severity as recalled by parents on the PGA, estimated by the within-patient score change (4.27), the between-patient score change (2.89) and the sensitivity and specificity method (3.00) was similar to the one half standard deviation of the POEM baseline scores (2.94) and the effect size estimate (2.50).
  
  
  
  The Patient-Oriented Eczema Measure as applied to young children is responsive to change, and the MCID is around 3. This study will encourage the use of POEM and aid in determining sample size for future randomized controlled trials of treatments for eczema in young children.
authors.affiliation: Bristol Randomised Trials Collaboration, School of Social and Community Medicine, University of Bristol, Bristol, UK. daisy.gaunt@bristol.ac.uk.
authors.forename: D M
authors.initials: DM
authors.lastname: Gaunt
authors.affiliation: Bristol Randomised Trials Collaboration, School of Social and Community Medicine, University of Bristol, Bristol, UK.
authors.forename: C
authors.initials: C
authors.lastname: Metcalfe
authors.affiliation: Centre for Academic Primary Care, School of Social and Community Medicine, University of Bristol, Bristol, UK.
authors.forename: M
authors.initials: M
authors.lastname: Ridd
mesh_terms: D002648:Child; D002675:Child, Preschool; D004485:Eczema / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D000071081:Minimal Clinically Important Difference; D000071066:Patient Reported Outcome Measures; D012372:ROC Curve; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors
keywords: Patient-Oriented Eczema Measure; atopic eczema; minimal clinically important difference; paediatrics; responsiveness