title: The triad psoriasis-obesity-adipokine profile.
abstract: Psoriasis is a chronic inflammatory skin disease, often associated with overweight/obesity. The adipose tissue is a complex organ that secretes several adipokines, involved in the regulation of some metabolic processes, such as lipid metabolism, glucose homeostasis, angiogenesis, blood pressure and inflammation. In obesity, the distribution and function of adipose tissue, and the adipokine profile are altered. The unbalanced production of pro- and anti-inflammatory adipokines in obesity, contributes to the development of a chronic low-grade inflammation state, which seems to favour worsening of psoriasis lesion and a poorer response to treatment. In this review, we will debate published data concerning the current knowledge about the triad psoriasis-obesity-adipokine profile.
authors.affiliation: UCIBIO\REQUIMTE, Departamento de Ciências Biológicas, Laboratório de Bioquímica, Faculdade de Farmácia, Universidade do Porto (FFUP), Porto, Portugal. ssn.coimbra@gmail.com.|CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, GRD-Paredes, Portugal. ssn.coimbra@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Coimbra
authors.affiliation: UCIBIO\REQUIMTE, Departamento de Ciências Biológicas, Laboratório de Bioquímica, Faculdade de Farmácia, Universidade do Porto (FFUP), Porto, Portugal.
authors.forename: C
authors.initials: C
authors.lastname: Catarino
authors.affiliation: UCIBIO\REQUIMTE, Departamento de Ciências Biológicas, Laboratório de Bioquímica, Faculdade de Farmácia, Universidade do Porto (FFUP), Porto, Portugal. assilva@ff.up.pt.
authors.forename: A
authors.initials: A
authors.lastname: Santos-Silva
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D006801:Humans; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D011565:Psoriasis / Q000150:complications / Q000378:metabolism* / Q000628:therapy
chemical_list: D054392:Adipokines