title: Seven-year Observational Study on the Association between Glycemic Control and the New Onset of Macroangiopathy in Japanese Subjects with Type 2 Diabetes.
abstract: Objective To examine the association between glycemic control and the new onset of macroangiopathy in Japanese subjects with type 2 diabetes. Methods We examined seven-year follow-up data for 572 patients. We divided the subjects by the average of seven-year glycemic control based on the guidelines. First, we excluded the subjects with a past history of macroangiopathy and then examined the incidence of the new onset of macroangiopathy. Results The incidence of ischemic heart disease (IHD) was 1.0% per year, and that of cerebral vascular disease (CVD) was 1.0% per year. However, IHD events were not observed at all for five years in the most intensive glycemic control group (HbA1c<6%). Similarly, CVD events were not observed at all for seven years in the most intensive glycemic control group (HbA1c<6%). In addition, the cumulative incidence rate of IHD tended to increase as the glycemic control became poorer (HbA1c<6%, 4.5%; 6%≤HbA1c<7%, 6.0%; 7%≤HbA1c<8%, 7.2%; HbA1c≥8%, 10.7%). Furthermore, a logistic regression analysis showed that the duration of diabetes and HbA1c level were independent risk factors contributing to the onset of IHD, but not to the onset of CVD. Conclusion This seven-year observational study showed the possible association between glycemic control and the onset of macroangiopathy in a total of 572 Japanese subjects with type 2 diabetes.
authors.affiliation: Division of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Kimura
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kanda-Kimura
authors.forename: Masashi
authors.initials: M
authors.lastname: Shimoda
authors.forename: Shinji
authors.initials: S
authors.lastname: Kamei
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Anno
authors.forename: Fumiko
authors.initials: F
authors.lastname: Kawasaki
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Hashiramoto
authors.forename: Michihiro
authors.initials: M
authors.lastname: Matsuki
authors.forename: Tomoatsu
authors.initials: T
authors.lastname: Mune
authors.forename: Kohei
authors.initials: K
authors.lastname: Kaku
mesh_terms: D000368:Aged; D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D003925:Diabetic Angiopathies / Q000209:etiology*; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology; D012307:Risk Factors; D020521:Stroke / Q000209:etiology
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin