title: Metastatic Basosquamous Carcinoma: Report of Two Cases and Clinicopathological Considerations.
abstract: Basosquamous carcinoma is a rare cutaneous tumor considered by some authors as an aggressive type of basal cell carcinoma having a propensity for local recurrence and a potential risk for regional and distant metastatic spread. Herein we present 2 cases of basosquamous carcinoma of head and neck region, with metastatic spread to parotid gland (case 1) and to cervical nodes (case 2). Both patients had recurrence 2 years after initial treatment of the primary lesion (first patient: surgery; second patient: radiotherapy) and at the same time developed regional metastases. We conclude that basosquamous carcinoma must be considered as an aggressive variant of basal cell carcinoma having a great propensity to metastasize even at an early tumor stage. The clinical features, the morphologic aspects, and the treatment of this rare entity are discussed in this article.
authors.affiliation: Department of Maxillofacial Surgery, University of Verona, Verona, Italy tommax78@yahoo.it.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Bucci
authors.affiliation: Department of Laboratory and Services, Institute of Histopathology and Diagnostic Cytopathology, Fondazione di Ricerca e Cura "Giovanni Paolo II"-UCSC, Campobasso, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Santoro
authors.affiliation: Department of Clinical and Experimental Medicine, Institute of Pathological Anatomy, University of Foggia, Foggia, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pannone
authors.affiliation: Department of Oral and Maxilofacial Surgery, Joan XXIII Hospital, Tarragona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Rodriguez
authors.affiliation: Department of Maxillofacial Surgery, University of Verona, Verona, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Fior
authors.affiliation: Department of Maxillofacial Surgery, University of Verona, Verona, Italy.
authors.forename: Pier Francesco
authors.initials: PF
authors.lastname: Nocini
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002281:Carcinoma, Basosquamous / Q000473:pathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: basosquamous cell carcinoma; head and neck tumor; regional metastases