title: Prediction of the treatment outcome using intravoxel incoherent motion and diffusional kurtosis imaging in nasal or sinonasal squamous cell carcinoma patients.
abstract: OBJECTIVE
  To evaluate the diagnostic value of intravoxel incoherent motion (IVIM) and diffusional kurtosis imaging (DKI) parameters in nasal or sinonasal squamous cell carcinoma (SCC) patients to determine local control/failure.
  
  
  METHODS
  Twenty-eight patients were evaluated. MR acquisition used single-shot spin-echo EPI with 12 b-values. Quantitative parameters (mean value, 25th, 50th and 75th percentiles) of IVIM (perfusion fraction f, pseudo-diffusion coefficient D*, and true-diffusion coefficient D), DKI (kurtosis value K, kurtosis corrected diffusion coefficient Dk) and apparent diffusion coefficient (ADC) were calculated. Parameter values at both the pretreatment and early-treatment period, and the percentage change between these two periods were obtained.
  
  
  RESULTS
  Multivariate logistic regression analysis: the percentage changes of D (mean, 25th, 50th, 75th), K (mean, 50th, 75th), Dk (mean, 25th, 50th), and ADC (mean, 25th, 50th) were predictors of local control. ROC curve analysis: the parameter with the highest accuracy = the percentage change of D value with the histogram 25th percentile (0.93 diagnostic accuracy). Multivariate Cox regression analyses: the percentage changes of D (mean, 25th, 50th), K (mean, 50th, 75th), Dk (mean, 25th, 50th) and ADC (mean, 25th, 50th) are predictors.
  
  
  CONCLUSIONS
  IVIM and DKI parameters, especially the D-value's histogram 25th percentile, are useful for predicting local control.
  
  
  CONCLUSIONS
  • Noninvasive assessment of treatment outcome in SCC patients was achieved using IVIM/DKI. • Several IVIM and DKI parameters can predict the local control. • Especially, the D-value's histogram 25th percentile has high diagnostic accuracy.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, N15, W7, Kita-Ku, Sapporo, 060-8638, Hokkaido, Japan. Noriyuki.Fujima@mb9.seikyou.ne.jp.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Fujima
authors.affiliation: Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, N15, W7, Kita-Ku, Sapporo, 060-8638, Hokkaido, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yoshida
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sakashita
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Homma
authors.affiliation: Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, N15, W7, Kita-Ku, Sapporo, 060-8638, Hokkaido, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Tsukahara
authors.affiliation: Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, N15, W7, Kita-Ku, Sapporo, 060-8638, Hokkaido, Japan.
authors.forename: Yukie
authors.initials: Y
authors.lastname: Shimizu
authors.affiliation: Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.|The Global Station for Quantum Medical Science and Engineering, Global Institution for Collaborative Research and Education, Sapporo, Japan.
authors.forename: Khin Khin
authors.initials: KK
authors.lastname: Tha
authors.affiliation: Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, N15, W7, Kita-Ku, Sapporo, 060-8638, Hokkaido, Japan.
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Kudo
authors.affiliation: Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.|The Global Station for Quantum Medical Science and Engineering, Global Institution for Collaborative Research and Education, Sapporo, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shirato
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009038:Motion; D009296:Nasal Cavity / Q000000981:diagnostic imaging; D009669:Nose Neoplasms / Q000000981:diagnostic imaging*; D012372:ROC Curve; D015203:Reproducibility of Results; D016896:Treatment Outcome
keywords: Diffusion magnetic resonance imaging; Magnetic resonance imaging; Prognosis; Squamous cell carcinoma of the head and neck; Treatment outcome