title: Therapeutic implications of autoantibodies in rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by the presence of autoantibodies. Their value for diagnostic/prognostic purposes has been well established. In contrast, their role in established disease and their associations with disease activity is less clear. Moreover, as evidence is accumulating that these autoantibodies are causally involved in certain key aspects of the disease, such as the initiation and perpetuation of joint inflammation or join destruction, autoantibodies in RA can no longer be regarded as mere epiphenomena, but are integral elements of the pathophysiology of RA.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine 3 , Medical University Vienna , Vienna , Austria.
authors.forename: Daniel
authors.initials: D
authors.lastname: Aletaha
authors.affiliation: Division of Rheumatology, Department of Internal Medicine 3 , Medical University Vienna , Vienna , Austria.
authors.forename: Stephan
authors.initials: S
authors.lastname: Blüml
keywords: Autoantibodies; Rheumatoid Arthritis; Rheumatoid Factor