title: Dysglycemia and Glucose Control During Sepsis.
abstract: Sepsis predisposes to disordered metabolism and dysglycemia; the latter is a broad term that includes hyperglycemia, hypoglycemia, and glycemic variability. Dysglycemia is a marker of illness severity. Large randomized controlled trials have provided considerable insight into the optimal blood glucose targets for critically ill patients with sepsis. However, it may be that the pathophysiologic consequences of dysglycemia are dynamic throughout the course of a septic insult and also altered by premorbid glycemia. This review highlights the relevance of hyperglycemia, hypoglycemia, and glycemic variability in patients with sepsis with an emphasis on a rational approach to management.
authors.affiliation: Discipline of Acute Care Medicine, University of Adelaide, North Terrace, Adelaide 5000, Australia; Department of Critical Care Services, Royal Adelaide Hospital, North Terrace, Adelaide 5000, Australia. Electronic address: mark.philip.plummer@gmail.com.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Plummer
authors.affiliation: Discipline of Acute Care Medicine, University of Adelaide, North Terrace, Adelaide 5000, Australia; Department of Critical Care Services, Royal Adelaide Hospital, North Terrace, Adelaide 5000, Australia.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Deane
mesh_terms: D015415:Biomarkers / Q000097:blood*; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology*; D007003:Hypoglycemia / Q000209:etiology*; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D018805:Sepsis / Q000150:complications*
chemical_list: D015415:Biomarkers; D007328:Insulin
keywords: Glycemic variability; Hyperglycemia; Hypoglycemia; Sepsis