title: Bile acid sensitivity and in vivo virulence of clinical Clostridium difficile isolates.
abstract: Clostridium difficile is an anaerobic bacterium that causes diarrheal illnesses. Disease onset is linked with exposure to oral antibiotics and consequent depletion of secondary bile acids. Here we investigate the relationship between in vitro secondary bile acid tolerance and in vivo disease scores of diverse C. difficile strains in mice.
authors.affiliation: Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Programs, Sloan Kettering Institute, New York, NY, 10065, United States.
authors.forename: Brittany B
authors.initials: BB
authors.lastname: Lewis
authors.affiliation: Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Programs, Sloan Kettering Institute, New York, NY, 10065, United States.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Carter
authors.affiliation: Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Programs, Sloan Kettering Institute, New York, NY, 10065, United States. Electronic address: pamere@mskcc.org.
authors.forename: Eric G
authors.initials: EG
authors.lastname: Pamer
mesh_terms: D000818:Animals; D016360:Clostridioides difficile / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity*; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology*; D006801:Humans; D008095:Lithocholic Acid / Q000494:pharmacology*; D008810:Mice, Inbred C57BL; D050296:Microbial Viability; D013171:Spores, Bacterial / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity*; D014774:Virulence
chemical_list: D008095:Lithocholic Acid
keywords: Clostridium difficile; Secondary bile acid