title: Assessment of serum chemerin, vaspin and omentin-1 levels in patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  To determine serum chemerin, vaspin and omentin-1 in overweight and normal weight patients with polycystic ovary syndrome (PCOS) and investigate the possible relationship between these adipokines and metabolic syndrome.
  
  
  METHODS
  This cross sectional study enrolled women with PCOS and healthy women. Serum chemerin, vaspin and omentin-1 were assessed by enzyme-linked immunosorbent assay methods.
  
  
  RESULTS
  Forty patients with PCOS and 30 healthy controls were included in the study. In the PCOS group, 18 women were overweight (body mass index [BMI] = 25.0-29.9 kg/m(2)) and 22 had normal weight (BMI = 18.5-24.9 kg/m(2)). Chemerin, total cholesterol, dehydroepiandrosterone sulphate and free androgen index (FAI) were significantly higher; and high-density lipoprotein cholesterol and sex hormone binding globulin were significantly lower in overweight PCOS patients compared with normal weight PCOS patients. A positive correlation was found between chemerin and BMI, triglyceride, insulin, homeostatic model assessment of insulin resistance and FAI in the PCOS group. There was no difference in serum chemerin, vaspin and omentin-1 between PCOS patients and healthy controls.
  
  
  CONCLUSIONS
  Circulating chemerin was increased in overweight compared with normal weight PCOS patients. The most predictive variables for circulating chemerin in PCOS patients were BMI, FAI and age.
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Celal Bayar University, Manisa, Turkey yesim.guvenc@gmail.com.
authors.forename: Yesim
authors.initials: Y
authors.lastname: Guvenc
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Var
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
authors.forename: Asli
authors.initials: A
authors.lastname: Goker
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
authors.forename: Naci Kemal
authors.initials: NK
authors.lastname: Kuscu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D037102:Lectins / Q000097:blood*; D015999:Multivariate Analysis; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D012044:Regression Analysis; D015843:Serpins / Q000097:blood*
chemical_list: D018925:Chemokines; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D037102:Lectins; C478630:RARRES2 protein, human; C507339:SERPINA12 protein, human; D015843:Serpins
keywords: Polycystic ovary syndrome; adipokines; chemerin; omentin-1; vaspin