title: Host factors are dominant in the development of post-liver transplant non-alcoholic steatohepatitis.
abstract: Non-alcoholic fatty liver disease (NAFLD) is a recognized problem in patients after orthotopic liver transplantation and may lead to recurrent graft injury. As the increased demand for liver allografts fail to match the available supply of donor organs, split liver transplantation (SLT) has emerged as an important technique to increase the supply of liver grafts. SLT allows two transplants to occur from one donor organ, and provides a unique model for observing the pathogenesis of NAFLD with respect to the role of recipient environmental and genetic factors. Here we report on two recipients of a SLT from the same deceased donor where only one developed non-alcoholic steatohepatitis (NASH), suggesting that host factors are critical for the development of NASH.
authors.affiliation: Salih Boga, Michael L Schilsky, Division of Digestive Diseases, Section of Transplantation and Immunology, Department of Medicine and Surgery, Yale University School of Medicine, New Haven, CT 06520, United States.
authors.forename: Salih
authors.initials: S
authors.lastname: Boga
authors.affiliation: Salih Boga, Michael L Schilsky, Division of Digestive Diseases, Section of Transplantation and Immunology, Department of Medicine and Surgery, Yale University School of Medicine, New Haven, CT 06520, United States.
authors.forename: Armando Salim
authors.initials: AS
authors.lastname: Munoz-Abraham
authors.affiliation: Salih Boga, Michael L Schilsky, Division of Digestive Diseases, Section of Transplantation and Immunology, Department of Medicine and Surgery, Yale University School of Medicine, New Haven, CT 06520, United States.
authors.forename: Manuel I
authors.initials: MI
authors.lastname: Rodriguez-Davalos
authors.affiliation: Salih Boga, Michael L Schilsky, Division of Digestive Diseases, Section of Transplantation and Immunology, Department of Medicine and Surgery, Yale University School of Medicine, New Haven, CT 06520, United States.
authors.forename: Sukru H
authors.initials: SH
authors.lastname: Emre
authors.affiliation: Salih Boga, Michael L Schilsky, Division of Digestive Diseases, Section of Transplantation and Immunology, Department of Medicine and Surgery, Yale University School of Medicine, New Haven, CT 06520, United States.
authors.forename: Dhanpat
authors.initials: D
authors.lastname: Jain
authors.affiliation: Salih Boga, Michael L Schilsky, Division of Digestive Diseases, Section of Transplantation and Immunology, Department of Medicine and Surgery, Yale University School of Medicine, New Haven, CT 06520, United States.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Schilsky
keywords: Host factors; Liver; Split graft; Steatohepatitis; Transplant