title: Trends in life expectancy of HIV-positive adults on antiretroviral therapy across the globe: comparisons with general population.
abstract: Improved virological and immunological outcomes and reduced toxicity of antiretroviral combination therapy (ART) raise the hope that life expectancy of HIV-positive persons on ART will approach that of the general population. We systematically review the literature and summarize published estimates of life expectancy of HIV-positive populations on ART. We compare their life expectancy with the life expectancy of the general or, in sub-Saharan Africa, HIV-negative populations, by time period and gender.
  
  
  
  Ten relevant studies were published from 2006 to 2015. Three studies were from Canada, two from European countries, three from sub-Saharan Africa and two were multicountry studies. Life expectancy increased over time in all studies and regions. Expressed as the percentage of life expectancy in the HIV-negative or general population, estimated life expectancy at age 20 years in HIV-positive people on ART ranged from 60.3% (95% CI 58.0-62.6%) in Rwanda (2008-2011) to 89.1% (95% CI 84.7-93.6%) in Canada (2008-2012). The percentage of life expectancy in the HIV-negative or general population achieved was higher in HIV-positive women than in HIV-positive men in all countries, except for Canada wherein the opposite was the case.
  
  
  
  Life expectancy in HIV-positive people on ART has improved worldwide in recent years, but important gaps remain compared with the general and HIV-negative population, and between regions and genders.
authors.affiliation: aDepartment of Infectious Diseases, Bern University Hospital, University of Bern, SwitzerlandbInstitute of Social and Preventive Medicine (ISPM), University of Bern, SwitzerlandcDepartment of Infectious Diseases, University of Dakar, SenegaldCentre for Infectious Disease Epidemiology and Research (CIDER), University of Cape Town, South Africa.
authors.forename: Gilles
authors.initials: G
authors.lastname: Wandeler
authors.forename: Leigh F
authors.initials: LF
authors.lastname: Johnson
authors.forename: Matthias
authors.initials: M
authors.lastname: Egger
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D005260:Female; D014943:Global Health; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008017:Life Expectancy; D008297:Male
chemical_list: D044966:Anti-Retroviral Agents