title: Randomized Controlled Trial of Prophylactic Negative-Pressure Wound Therapy at Ostomy Closure for the Prevention of Delayed Wound Healing and Surgical Site Infection in Patients with Ulcerative Colitis.
abstract: OBJECTIVE
  Although negative-pressure wound therapy (NPWT) is likely advantageous for wound healing, the efficacy and safety of its prophylactic use remain unclear for digestive surgery. We performed a prospective randomized controlled study to evaluate the efficacy and safety of this procedure during ileostomy closure.
  
  
  METHODS
  We conducted a prospective, randomized study between November 2014 and September 2015. Patients with ulcerative colitis scheduled to undergo ileostomy closure with purse-string suture (PSS) were randomly divided into groups with or without NPWT. The primary endpoint was complete wound healing. The secondary endpoints were incidences of wound complications.
  
  
  RESULTS
  A total of 31 patients with PSS alone and 28 patients with PSS + NPWT were enrolled. Wound infection was observed in 1 patient in the PSS-alone condition and 3 patients in the PSS + NPWT condition (p = 0.76). The mean duration of complete wound healing was 37.6 ± 11.7 days in the PSS-alone condition and 33.5 ± 10.0 days in the PSS + NPWT condition (p = 0.18).
  
  
  CONCLUSIONS
  Although no adverse effects were observed in this series, the efficacy of PSS + NPWT was not confirmed. Further clarification of the indication of prophylactic NPWT and its efficacy must be obtained, and the efficacy and safety of NPWT in different dirty/infected surgeries should be evaluated.
authors.affiliation: Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Motoi
authors.initials: M
authors.lastname: Uchino
authors.forename: Kei
authors.initials: K
authors.lastname: Hirose
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Bando
authors.forename: Teruhiro
authors.initials: T
authors.lastname: Chohno
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takesue
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ikeuchi
mesh_terms: D058107:Abdominal Wound Closure Techniques; D000328:Adult; D003093:Colitis, Ulcerative / Q000601:surgery; D005260:Female; D006801:Humans; D007081:Ileostomy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000209:etiology / Q000517:prevention & control*; D013997:Time Factors; D014945:Wound Healing; D055815:Young Adult