title: Pandoraea pnomenusa Isolated from an Australian Patient with Cystic Fibrosis.
abstract: Pandoraea species are considered as emerging pathogens in people with cystic fibrosis (CF). The contribution of these organisms to disease progression in CF patients is not fully understood owing in large measure to the scant reports in clinical and research literature describing their colonization of CF patients and their associated virulence determinants. In an effort to increase awareness and evidence for Pandoraea spp. infection in people with CF, and to stimulate research aimed at unraveling the pathogenic properties of Pandoraea, we report a case of a 26-year-old Australian (Tasmanian) man with CF who was chronically infected with Pandoraea pnomenusa for at least one year prior to his death from respiratory failure. In addition, we describe for the first time evidence suggesting that this bacterium is a facultative anaerobe and report on the availability of a whole genome sequence for this organism. To the best of our knowledge, this report represents only the second clinical case study of P. pnomenusa infection in the world, and the first in an Australian CF patient.
authors.affiliation: School of Medicine, University of Tasmania Tasmania, TAS, Australia.
authors.forename: Mark
authors.initials: M
authors.lastname: Ambrose
authors.affiliation: School of Medicine, University of TasmaniaTasmania, TAS, Australia; Department of Pathology, Royal Hobart HospitalTasmania, TAS, Australia.
authors.forename: Roslyn C
authors.initials: RC
authors.lastname: Malley
authors.affiliation: Department of Microbiology and Infectious Diseases, Royal Hobart Hospital Tasmania, TAS, Australia.
authors.forename: Sanchia J C
authors.initials: SJ
authors.lastname: Warren
authors.affiliation: School of Medicine, University of TasmaniaTasmania, TAS, Australia; Department of Paediatrics, Royal Hobart HospitalTasmania, TAS, Australia.
authors.forename: Sean A
authors.initials: SA
authors.lastname: Beggs
authors.affiliation: School of Medicine, University of Tasmania Tasmania, TAS, Australia.
authors.forename: Oliver F E
authors.initials: OF
authors.lastname: Swallow
authors.affiliation: Department of Microbiology and Infectious Diseases, Royal Hobart Hospital Tasmania, TAS, Australia.
authors.forename: Belinda
authors.initials: B
authors.lastname: McEwan
authors.affiliation: Department of Respiratory and General Medicine, Royal Hobart Hospital Tasmania, TAS, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Stock
authors.affiliation: School of Medicine, University of Tasmania Tasmania, TAS, Australia.
authors.forename: Louise F
authors.initials: LF
authors.lastname: Roddam
keywords: Pandoraea; anaerobe; cystic fibrosis; infection; lung