title: Long-Term Prognosis of Spontaneous Intracerebral Hemorrhage on the Tibetan Plateau: A Prospective Cohort Study at 2 Hospitals.
abstract: BACKGROUND
  Patterns of intracerebral hemorrhage (ICH) and outcomes in Tibetans are poorly understood. We aimed to investigate the long-term outcomes of Tibetan ICH patients.
  
  
  METHODS
  This prospective study involved a consecutive series of ICH patients admitted within 1 month of onset to West China Hospital (WCH) on the Chengdu Plain or People's Hospital of Garzê (PHG) on the Tibetan Plateau between January 2013 and December 2013. Basic characteristics and functional outcomes were compared between PHG and WCH groups.
  
  
  RESULTS
  Of the 843 cases included, 105 (12.5%) were from PHG and 738 (87.5%) were from WCH. Compared with patients from WCH, patients from PHG were older and had higher blood pressure on admission, and a greater proportion had hypertension (all P < 0.001). Among patients from PHG, the 1-year death rate was 30.5%, similar to that in WCH (P = 0.987), and the adjusted 3-month disability risk was 2.0-fold higher than for WCH patients, while the adjusted 1-year disability risk was 2.5-fold higher than for WCH patients (both P ≤ 0.05). The adjusted 3-month risk of disability/death was 2.1-fold higher in PHG patients than in WCH patients, while the adjusted 1-year risk was 2.4-fold higher (both P ≤ 0.05).
  
  
  CONCLUSIONS
  Most cases of ICH on the Tibetan Plateau involve concomitant hypertension. Tibetan patients are at higher risk of disability or disability/death on follow-up than are patients from Chengdu Plain.
authors.affiliation: Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Ruozhen
authors.initials: R
authors.lastname: Yuan
authors.affiliation: Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China. Electronic address: wdr0128@qq.com.
authors.forename: Deren
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China. Electronic address: wyplmh@hotmail.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurology, People's Hospital of Garzê, Garzê, P.R. China.
authors.forename: Yongqiao
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Neurology, People's Hospital of Garzê, Garzê, P.R. China.
authors.forename: Yongyi
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Lei
authors.affiliation: Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Zilong
authors.initials: Z
authors.lastname: Hao
authors.affiliation: Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Wendan
authors.initials: W
authors.lastname: Tao
authors.affiliation: Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Bian
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Xueli
authors.initials: X
authors.lastname: Chang
authors.affiliation: Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Qiuxiao
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Neurology, Stroke Clinical Research Unit, West China Hospital, Sichuan University, Chengdu, P.R. China.
authors.forename: Ge
authors.initials: G
authors.lastname: Tan
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D015897:Comorbidity; D004185:Disability Evaluation; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000401:mortality*; D020300:Intracranial Hemorrhages / Q000175:diagnosis / Q000401:mortality*; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D020521:Stroke / Q000175:diagnosis / Q000401:mortality*; D015996:Survival Rate; D018609:Tibet / Q000453:epidemiology
keywords: Comparative study; High-altitude; Intracerebral hemorrhage; Long-term outcomes; Tibetan plateau