title: Early Changes in Atrial Electromechanical Coupling in Patients with Hypertension: Assessment by Tissue Doppler Imaging.
abstract: BACKGROUND
  Hypertension (HT) is associated with atrial electrophysiological abnormalities. Echocardiographic pulsed wave tissue Doppler imaging (TDI) is one of the noninvasive methods for evaluation of atrial electromechanical properties. The aims of our study were to investigate the early changes in atrial electromechanical conduction in patients with HT and to assess the parameters that affect atrial electromechanical conduction.
  
  
  METHODS
  Seventy-six patients with HT (41 males, mean age 52.6 ± 9.0 years) and 41 controls (22 males, mean age 49.8 ± 7.9 years) were included in the study. Atrial electromechanical coupling at the right (PRA), left (PLA), interatrial septum (PIS) were measured with TDI. Intra- (right: PIS-PRA, left: PLA-PIS) and inter-atrial (PLA-PRA) electromechanical delays were calculated. Maximum P-wave duration (Pmax) was calculated from 12-lead electrocardiogram.
  
  
  RESULTS
  Atrial electromechanical coupling at PLA (76.6 ± 14.1 ms vs. 82.9 ± 15.8 ms, P = 0.036), left intra-atrial (10.9 ± 5.0 ms vs. 14.0 ± 9.7 ms, P = 0.023), right intra-atrial (10.6 ± 7.8 ms vs. 14.5 ± 10.1 ms, P = 0.035), and interatrial electromechanical (21.4 ± 9.8 ms vs. 28.3 ± 12.7 ms, P = 0.003) delays were significantly longer in patients with HT. The linear regression analysis showed that left ventricular (LV) mass index and Pmax were significantly associated with PLA (P = 0.001 and P = 0.002, respectively), and the LV mass index was the only related factor for interatrial delay (P = 0.001).
  
  
  CONCLUSIONS
  Intra- and interatrial electromechanical delay, PLA were significantly prolonged in hypertensive patients. LV mass index and Pmax were significantly associated with PLA, and the LV mass index was the only related factor for interatrial delay. The atrial TDI can be a valuable method to assess the early changes of atrial electromechanical conduction properties in those patients.
authors.affiliation: Department of Cardiology, Baskent University, Istanbul Medical and Research Center, Oymacı Sok, 34662 Altunizade, Istanbul, Turkey.
authors.forename: Burcak Kilickiran
authors.initials: BK
authors.lastname: Avci
authors.affiliation: Department of Cardiology, Baskent University, Istanbul Medical and Research Center, Oymacı Sok, 34662 Altunizade, Istanbul, Turkey.
authors.forename: Oyku
authors.initials: O
authors.lastname: Gulmez
authors.affiliation: Department of Cardiology, Baskent University, Istanbul Medical and Research Center, Oymacı Sok, 34662 Altunizade, Istanbul, Turkey.
authors.forename: Guclu
authors.initials: G
authors.lastname: Donmez
authors.affiliation: Department of Cardiology, Baskent University, Istanbul Medical and Research Center, Oymacı Sok, 34662 Altunizade, Istanbul, Turkey.
authors.forename: Seckin
authors.initials: S
authors.lastname: Pehlivanoglu
mesh_terms: D000328:Adult; D003324:Coronary Artery Disease / Q000503:physiopathology; D015150:Echocardiography, Doppler / Q000379:methods*; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged