title: Association of the DISC1 and NRG1 genetic polymorphisms with schizophrenia in a Chinese population.
abstract: Polymorphisms in Disrupted-in-Schizophrenia 1 (DISC1) and Neuregulin 1 (NRG1) might be associated with schizophrenia; however, the conclusions of relevant studies were inconsistent across different ethnic populations. This population-based case-control study was carried out to determine whether polymorphisms in these two genes could be associated with schizophrenia in the Chinese population. A case-control study of 248 schizophrenia patients and 236 controls was performed with the Sequenom MassARRAY platform. The results revealed that the DISC1 rs821616 heterozygous (AT vs. AA: adjusted OR, 1.98, 95%CI: 1.30-3.02) and co-dominant (AT/TT vs. AA: adjusted OR=1.94; 95%CI: 1.29-2.92) patterns were associated with increased risk for developing schizophrenia in all participants and subgroups (stratified by sex and age at onset), respectively. Moreover, in the male subgroup, the DISC1 rs821597 genotype GA or GA/AA exhibited increased risk of schizophrenia. For NRG1 polymorphisms, in the early onset subgroup (≤25years), the rs3924999 G/G genotype was susceptible to schizophrenia. The interaction of DISC1 rs821616 T allele with the NRG1 rs3924999 A allele or that of DISC1 rs821597 A allele with NRG1 rs3924999 A allele had synergic effects on the development of schizophrenia. This study concluded that carriers of the DISC1 rs821616 T allele have increased risk for developing schizophrenia, and that the DISC1 rs821597 A allele was susceptible to schizophrenia for the male, and that there are marked interactions between the DISC1 rs821616 T and/or rs821597 A alleles and the NRG1 rs3924999 A allele for the development of schizophrenia.
authors.affiliation: General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
authors.forename: Bang-Shun
authors.initials: BS
authors.lastname: He
authors.affiliation: Zutangshan Hospital, Nanjing 211153, China.
authors.forename: Ling-Yun
authors.initials: LY
authors.lastname: Zhang
authors.affiliation: General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Pan
authors.affiliation: General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Lin
authors.affiliation: Zutangshan Hospital, Nanjing 211153, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Zhang
authors.affiliation: General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Sun
authors.affiliation: General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
authors.forename: Tian-Yi
authors.initials: TY
authors.lastname: Gao
authors.affiliation: Zutangshan Hospital, Nanjing 211153, China.
authors.forename: Tai-Qin
authors.initials: TQ
authors.lastname: Su
authors.affiliation: General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China. Electronic address: shukwang@163.com.
authors.forename: Shu-Kui
authors.initials: SK
authors.lastname: Wang
authors.affiliation: Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China. Electronic address: chbinzhu@126.com.
authors.forename: Cheng-Bin
authors.initials: CB
authors.lastname: Zhu
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020890:Neuregulin-1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C412476:DISC1 protein, human; C094131:NRG1 protein, human; D009419:Nerve Tissue Proteins; D020890:Neuregulin-1
keywords: DISC1; NRG1; Polymorphism; Schizophrenia