title: Top-down cortical input during NREM sleep consolidates perceptual memory.
abstract: During tactile perception, long-range intracortical top-down axonal projections are essential for processing sensory information. Whether these projections regulate sleep-dependent long-term memory consolidation is unknown. We altered top-down inputs from higher-order cortex to sensory cortex during sleep and examined the consolidation of memories acquired earlier during awake texture perception. Mice learned novel textures and consolidated them during sleep. Within the first hour of non-rapid eye movement (NREM) sleep, optogenetic inhibition of top-down projecting axons from secondary motor cortex (M2) to primary somatosensory cortex (S1) impaired sleep-dependent reactivation of S1 neurons and memory consolidation. In NREM sleep and sleep-deprivation states, closed-loop asynchronous or synchronous M2-S1 coactivation, respectively, reduced or prolonged memory retention. Top-down cortical information flow in NREM sleep is thus required for perceptual memory consolidation.
authors.affiliation: Laboratory for Behavioral Neurophysiology, RIKEN Brain Science Institute, Wako, Saitama, Japan. Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan. Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. Japan Society for the Promotion of Science Research Fellow, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo, 102-0083, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Miyamoto
authors.affiliation: Laboratory for Behavioral Neurophysiology, RIKEN Brain Science Institute, Wako, Saitama, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Hirai
authors.affiliation: Laboratory for Neural Circuit Theory, RIKEN Brain Science Institute, Wako, Saitama, Japan.
authors.forename: C C A
authors.initials: CC
authors.lastname: Fung
authors.affiliation: Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Inutsuka
authors.affiliation: Laboratory for Behavioral Neurophysiology, RIKEN Brain Science Institute, Wako, Saitama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Odagawa
authors.affiliation: Laboratory for Behavioral Neurophysiology, RIKEN Brain Science Institute, Wako, Saitama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wako, Saitama, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Boehringer
authors.affiliation: Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wako, Saitama, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Adaikkan
authors.affiliation: Laboratory for Behavioral Neurophysiology, RIKEN Brain Science Institute, Wako, Saitama, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Matsubara
authors.affiliation: Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Matsuki
authors.affiliation: Laboratory for Neural Circuit Theory, RIKEN Brain Science Institute, Wako, Saitama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fukai
authors.affiliation: Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wako, Saitama, Japan.
authors.forename: T J
authors.initials: TJ
authors.lastname: McHugh
authors.affiliation: Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Yamanaka
authors.affiliation: Laboratory for Behavioral Neurophysiology, RIKEN Brain Science Institute, Wako, Saitama, Japan. masa_murayama@brain.riken.jp.
authors.forename: M
authors.initials: M
authors.lastname: Murayama
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D000075402:Channelrhodopsins; D000069077:Memory Consolidation / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D062308:Optogenetics; D010465:Perception; D021641:Recognition, Psychology; D066191:Sensorimotor Cortex / Q000502:physiology; D012895:Sleep, REM / Q000502:physiology*
chemical_list: D000075402:Channelrhodopsins