title: [THE FIRST RESULTS OF THE PREVALENCE OF CYP2C19 GENEPOLYMORPHISM IN PATIENTS WITH ACUTE CORONARY SYNDROME IN THE AKTYUBINSK POPULATION].
abstract: To study the prevalence of polymorphic variants of CYP2C19 in residents of the Aktyubinsk region, in patients with acute coronary syndrome after percutaneous coronary intervention. We studied included 100 patients with documented acute coronary syndrome, whom stent has been implanted and double antiplatelet therapy (aspirin and clopidogrel) was administered (average age was 49.2). The control group was formed of 255 volunteers without clinical and electrocardiographic manifestations of ischemia, and cardiovascular disease (CVD). In groups of patients and volunteers, most of them were ethnic Kazakhs 67% and 72% respectively. Thus, about 30% of patients CYP2C19*1/*2 acute coronary syndrome who live in Aktobe (Aktobe residents) are under the threat of a possible occurrence of new cardiovascular events due to low sensitivity to clopidogrel. Our study confirms that CYP2C19 G (681A) genotype has impact on antiplatelet effect of clopidogrel. The peculiarity of our work lies in the fact that we were the first who conducted pharmacogenetic study in patients treated with clopidogrel with ACS/PCI in the region inhabited by persons of mixed Slavic and Kazakh nationality.
authors.affiliation: West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan.
authors.forename: G
authors.initials: G
authors.lastname: Smagulova
authors.affiliation: West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan.
authors.forename: N
authors.initials: N
authors.lastname: Kulmurzaeva
authors.affiliation: West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan.
authors.forename: N
authors.initials: N
authors.lastname: Seytmaganbetova
authors.affiliation: West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan.
authors.forename: G
authors.initials: G
authors.lastname: Kurmanalina
authors.affiliation: West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan.
authors.forename: I
authors.initials: I
authors.lastname: Talipova
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy / Q000208:ethnology / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People; D001241:Aspirin / Q000627:therapeutic use; D000077144:Clopidogrel; D065731:Cytochrome P-450 CYP2C19 / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D007623:Kazakhstan; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011110:Polymorphism, Genetic; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D044465:White People
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D065731:Cytochrome P-450 CYP2C19; D013988:Ticlopidine; D001241:Aspirin