title: Assessment of the Central Effects of Natural Uranium via Behavioural Performances and the Cerebrospinal Fluid Metabolome.
abstract: Natural uranium (NU), a component of the earth's crust, is not only a heavy metal but also an alpha particle emitter, with chemical and radiological toxicity. Populations may therefore be chronically exposed to NU through drinking water and food. Since the central nervous system is known to be sensitive to pollutants during its development, we assessed the effects on the behaviour and the cerebrospinal fluid (CSF) metabolome of rats exposed for 9 months from birth to NU via lactation and drinking water (1.5, 10, or 40 mg·L(-1) for male rats and 40 mg·L(-1) for female rats). Medium-term memory decreased in comparison to controls in male rats exposed to 1.5, 10, or 40 mg·L(-1) NU. In male rats, spatial working memory and anxiety- and depressive-like behaviour were only altered by exposure to 40 mg·L(-1) NU and any significant effect was observed on locomotor activity. In female rats exposed to NU, only locomotor activity was significantly increased in comparison with controls. LC-MS metabolomics of CSF discriminated the fingerprints of the male and/or female NU-exposed and control groups. This study suggests that exposure to environmental doses of NU from development to adulthood can have an impact on rat brain function.
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, Pôle de la RadioProtection de l'Homme, Service de Radiobiologie et d'Epidémiologie, Laboratoire de RadioToxicologie Expérimentale, IRSN, BP 17, 92262 Fontenay-aux-Roses Cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Lestaevel
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, Pôle de la RadioProtection de l'Homme, Service de Radiobiologie et d'Epidémiologie, Laboratoire de RadioToxicologie Expérimentale, IRSN, BP 17, 92262 Fontenay-aux-Roses Cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Grison
authors.affiliation: Aix Marseille Université (AMU), NORT, 27 boulevard Jean Moulin, 13385 Marseille Cedex 5, France; Inserm, UMR-S 1062, 27 boulevard Jean Moulin, 13385 Marseille Cedex 5, France; Inra, UMR-INRA 1260, 27 boulevard Jean Moulin, 13385 Marseille Cedex 5, France.
authors.forename: G
authors.initials: G
authors.lastname: Favé
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, Pôle de la RadioProtection de l'Homme, Service de Radiobiologie et d'Epidémiologie, Laboratoire de RadioToxicologie Expérimentale, IRSN, BP 17, 92262 Fontenay-aux-Roses Cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Elie
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, Pôle de la RadioProtection de l'Homme, Service de Radiobiologie et d'Epidémiologie, Laboratoire de RadioToxicologie Expérimentale, IRSN, BP 17, 92262 Fontenay-aux-Roses Cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Dhieux
authors.affiliation: Aix Marseille Université (AMU), NORT, 27 boulevard Jean Moulin, 13385 Marseille Cedex 5, France; Inserm, UMR-S 1062, 27 boulevard Jean Moulin, 13385 Marseille Cedex 5, France; Inra, UMR-INRA 1260, 27 boulevard Jean Moulin, 13385 Marseille Cedex 5, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Martin
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, Pôle de la RadioProtection de l'Homme, Service de Radiobiologie et d'Epidémiologie, Laboratoire de RadioToxicologie Expérimentale, IRSN, BP 17, 92262 Fontenay-aux-Roses Cedex, France.
authors.forename: K
authors.initials: K
authors.lastname: Tack
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, Pôle de la RadioProtection de l'Homme, Service de Radiobiologie et d'Epidémiologie, Laboratoire de RadioToxicologie Expérimentale, IRSN, BP 17, 92262 Fontenay-aux-Roses Cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Souidi
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002555:Cerebrospinal Fluid / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D008124:Locomotion / Q000187:drug effects / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D055442:Metabolome / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D065852:Spatial Memory / Q000187:drug effects / Q000502:physiology; D014501:Uranium / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D014501:Uranium