title: Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection.
abstract: This study aimed to evaluate the association between body mass index (BMI) and progression in triple-negative breast cancer (TNBC). We retrospectively reviewed the medical records of 50 patients with TNBC who underwent breast-conserving surgery or mastectomy between 2007 and 2014. All patients were classified according to BMI (median 23.5 kg/m(2), range 17.2-31.6 kg/m(2)): 31 patients (62%) were classified as being overweight or obese (BMI ≥ 23 kg/m(2)) and 19 patients (38%) were classified as having a normal body weight (BMI < 23 kg/m(2)). The median follow-up for patients was 31.1 months (range, 6.7-101.9 months). Progression occurred in 7 patients (14%), including 5 ipsilateral breast tumor recurrences, 2 regional lymph node metastases, and 5 distant metastases. Progression was significantly correlated with overweight or obese patients (P = 0.035), while none of the normal weight patients showed progression. The 3-year disease-free survival (DFS) and overall survival (OS) rates were 85.0% and 87.7%, respectively. DFS was significantly reduced in overweight or obese patients compared to that in normal weight patients (P = 0.035). However, OS was not significantly compromised by being overweight or obese (P = 0.134). In conclusion, being overweight or obese negatively affects DFS in TNBC patients.
authors.affiliation: Department of Radiation Oncology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.; Department of Medicine, Yonsei University College of Medicine, Yonsei Graduate School, Seoul, Korea.
authors.forename: Yunseon
authors.identifier: 0000-0002-1397-6753
authors.initials: Y
authors.lastname: Choi
authors.affiliation: Department of Radiation Oncology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea .
authors.forename: Sung Kwang
authors.identifier: 0000-0001-8138-7638
authors.initials: SK
authors.lastname: Park
authors.affiliation: Department of Radiation Oncology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea .
authors.forename: Ki Jung
authors.identifier: 0000-0002-5163-0040
authors.initials: KJ
authors.lastname: Ahn
authors.affiliation: Department of Radiation Oncology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea .
authors.forename: Heunglae
authors.identifier: 0000-0002-9799-1538
authors.initials: H
authors.lastname: Cho
authors.affiliation: Department of Surgery, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea .
authors.forename: Tae Hyun
authors.identifier: 0000-0002-6675-8872
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Pathology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea .
authors.forename: Hye Kyoung
authors.identifier: 0000-0003-0714-8537
authors.initials: HK
authors.lastname: Yoon
authors.affiliation: Department of Medicine, Yonsei University College of Medicine, Yonsei Graduate School, Seoul, Korea.; Department of Molecular Medicine, College of Medicine, Keimyung University, Daegu, Korea.
authors.forename: Yun-Han
authors.identifier: 0000-0002-5746-6755
authors.initials: YH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009765:Obesity / Q000150:complications*; D050177:Overweight / Q000150:complications*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D064726:Triple Negative Breast Neoplasms / Q000150:complications* / Q000401:mortality / Q000473:pathology*
keywords: Body Mass Index; Obesity; Overweight; Prognosis; Triple-Negative Breast Cancer