title: Assembly of Double-Hydrophilic Block Copolymers Triggered by Gadolinium Ions: New Colloidal MRI Contrast Agents.
abstract: Mixing double-hydrophilic block copolymers containing a poly(acrylic acid) block with gadolinium ions in water leads to the spontaneous formation of polymeric nanoparticles. With an average diameter near 20 nm, the nanoparticles are exceptionally stable, even after dilution and over a large range of pH and ionic strength. High magnetic relaxivities were measured in vitro for these biocompatible colloids, and in vivo magnetic resonance imaging on rats demonstrates the potential utility of such polymeric assemblies.
authors.affiliation: Laboratoire des IMRCP, Université de Toulouse, CNRS UMR 5623, Université Paul Sabatier , 118, route de Narbonne 31062 Toulouse Cedex 9, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Frangville
authors.affiliation: Department of Chemistry, University of Florida , Gainesville, Florida 32611-7200, United States.
authors.forename: Yichen
authors.initials: Y
authors.lastname: Li
authors.affiliation: EMR 3738 Ciblage Thérapeutique en Oncologie, Université de Lyon, Université Jean Monnet , Hospices Civils de Lyon, 42023 Saint-Etienne Cedex 2, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Billotey
authors.affiliation: Department of Chemistry, University of Florida , Gainesville, Florida 32611-7200, United States.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Talham
authors.affiliation: EMR 3738 Ciblage Thérapeutique en Oncologie, Université de Lyon, Université Jean Monnet , Hospices Civils de Lyon, 42023 Saint-Etienne Cedex 2, France.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Taleb
authors.affiliation: EMR 3738 Ciblage Thérapeutique en Oncologie, Université de Lyon, Université Jean Monnet , Hospices Civils de Lyon, 42023 Saint-Etienne Cedex 2, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Roux
authors.affiliation: Laboratoire des IMRCP, Université de Toulouse, CNRS UMR 5623, Université Paul Sabatier , 118, route de Narbonne 31062 Toulouse Cedex 9, France.
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Marty
authors.affiliation: Laboratoire des IMRCP, Université de Toulouse, CNRS UMR 5623, Université Paul Sabatier , 118, route de Narbonne 31062 Toulouse Cedex 9, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Mingotaud
keywords: MRI; Polymer; block copolymer; gadolinium; micelle; nanoparticle