title: Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans.
abstract: Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of human BAT in lipid metabolism remains unknown. We studied 16 overweight/obese men during prolonged, non-shivering cold and thermoneutral conditions using stable isotopic tracer methodologies in conjunction with hyperinsulinemic-euglycemic clamps and BAT and white adipose tissue (WAT) biopsies. BAT volume was significantly associated with increased whole-body lipolysis, triglyceride-free fatty acid (FFA) cycling, FFA oxidation, and adipose tissue insulin sensitivity. Functional analysis of BAT and WAT demonstrated the greater thermogenic capacity of BAT compared to WAT, while molecular analysis revealed a cold-induced upregulation of genes involved in lipid metabolism only in BAT. The accelerated mobilization and oxidation of lipids upon BAT activation supports a putative role for BAT in the regulation of lipid metabolism in humans.
authors.affiliation: Metabolism Unit, Shriners Hospitals for Children, Galveston, TX 77555, USA; Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Nutrition and Metabolism, Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Nutrition and Dietetics, Harokopio University of Athens, Athens 176 71, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Chondronikola
authors.affiliation: Department of Nutrition and Metabolism, Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA; Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Elena
authors.initials: E
authors.lastname: Volpi
authors.affiliation: Metabolism Unit, Shriners Hospitals for Children, Galveston, TX 77555, USA; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Børsheim
authors.affiliation: Metabolism Unit, Shriners Hospitals for Children, Galveston, TX 77555, USA; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Craig
authors.initials: C
authors.lastname: Porter
authors.affiliation: Metabolism Unit, Shriners Hospitals for Children, Galveston, TX 77555, USA; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Manish K
authors.initials: MK
authors.lastname: Saraf
authors.affiliation: Department of Interventional Radiology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Palam
authors.initials: P
authors.lastname: Annamalai
authors.affiliation: Metabolism Unit, Shriners Hospitals for Children, Galveston, TX 77555, USA; Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Yfanti
authors.affiliation: Metabolism Unit, Shriners Hospitals for Children, Galveston, TX 77555, USA; Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Nutrition and Metabolism, Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Tony
authors.initials: T
authors.lastname: Chao
authors.affiliation: Diabetes Center, Department of Cell and Tissue Biology, and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Wong
authors.affiliation: Diabetes Center, Department of Cell and Tissue Biology, and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA.
authors.forename: Kosaku
authors.initials: K
authors.lastname: Shinoda
authors.affiliation: Quebec Heart and Lung Research Institute Centre, Quebec City, Quebec G1V 4G5, Canada.
authors.forename: Sebastien M
authors.initials: SM
authors.lastname: Labbė
authors.affiliation: Metabolism Unit, Shriners Hospitals for Children, Galveston, TX 77555, USA; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Nicholas M
authors.initials: NM
authors.lastname: Hurren
authors.affiliation: Department of Nuclear Medicine, University of Texas Medical Branch, Galveston, TX 77555-0177, USA.
authors.forename: Fernardo
authors.initials: F
authors.lastname: Cesani
authors.affiliation: Diabetes Center, Department of Cell and Tissue Biology, and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kajimura
authors.affiliation: Metabolism Unit, Shriners Hospitals for Children, Galveston, TX 77555, USA; Department of Nutrition and Metabolism, Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Nutrition and Dietetics, Harokopio University of Athens, Athens 176 71, Greece; Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA; Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Exercise Sciences, Rutgers University, New Brunswick, NJ 08901, USA; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA. Electronic address: lss133@rci.rutgers.edu.
authors.forename: Labros S
authors.initials: LS
authors.lastname: Sidossis
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism*; D003080:Cold Temperature; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D007700:Kinetics; D016014:Linear Models; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010084:Oxidation-Reduction / Q000187:drug effects
chemical_list: D007328:Insulin; D008055:Lipids; D008074:Lipoproteins