title: [Prenatal lead exposure related to cord blood brain derived neurotrophic factor (BDNF) levels and impaired neonatal neurobehavioral development].
abstract: OBJECTIVE
  To explore the relationship between umbilical cord blood brain-derived neurotrophic factor (BDNF) and neonatal neurobehavioral development in lead exposure infants.
  
  
  METHODS
  All infants and their mother were randomly selected during 2011 to 2012, subjects were selected according to the umbilical cord blood lead concentrations, which contcentration of lead was higher than 0.48 μmol/L were taken into high lead exposure group, about 60 subjects included. Comparing to the high lead exposure group, according to gender, weight, pregnant week, length and head circumferenece, the level of cord blood lead concentration under 0.48 μmol/L were taken into control group, 60 cases included. Lead content was determined by graphite furnace atomic absorption spectrometry. Neonatal behavioral neurological assessment (NBNA) was used to determine the development of neonatal neuronal behavior. The content of BDNF was detected by ELISA. Comparing the BDNF and the NBNA score between two groups, and linear correlation was given on analysis the correlation between lead concentration in cord blood and BDNF, BDNF and the NBNA score.
  
  
  RESULTS
  Lead content in high exposure group was (0.613±0.139) μmol/L, and higher than (0.336±0.142) μmol/L in low exposure group (t=3.21, P<0.001) . NBNA summary score (36.35±1.86), active muscle tension score (6.90±0.27) and general assessment score (5.93±0.32) in high exposure group were lower than those (38.13±0.96, 7.79±0.35, 6.00±0.00) in low exposure group (t values were 8.21, 10.23, 2.32, respectively, P values were <0.001, <0.001 and 0.037) . BDNF content in high exposure group which was (3.538±1.203) ng/ml was higher than low exposure group (2.464±0.918) ng/ml (t=7.60, P<0.001). The correlation analysis found that the cord blood BDNF content was negatively correlated with NBNA summary score, passive muscle tension and active muscle tone score (r was -0.27, -0.29, -0.30, respectively, P values were <0.001, respectively) .
  
  
  CONCLUSIONS
  Prenatal lead exposure results poor neonatal neurobehavioral development and cord blood BDNF was negatively correlated with neonatal neurodevelopment, may serve as a useful biomarker.
authors.affiliation: Department of Prevention and Health Care, Shanxi People's Hospital, Taiyuan 030012, China.
authors.forename: L H
authors.initials: LH
authors.lastname: Ren
authors.forename: X Y
authors.initials: XY
authors.lastname: Mu
authors.forename: H Y
authors.initials: HY
authors.lastname: Chen
authors.forename: H L
authors.initials: HL
authors.lastname: Yang
authors.forename: W
authors.initials: W
authors.lastname: Qi
mesh_terms: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D002648:Child; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000097:blood; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007223:Infant; D018730:Infant Behavior / Q000187:drug effects*; D007231:Infant, Newborn; D007854:Lead / Q000009:adverse effects* / Q000097:blood; D020264:Lead Poisoning, Nervous System, Childhood / Q000097:blood / Q000175:diagnosis; D009420:Nervous System / Q000187:drug effects* / Q000254:growth & development; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D004785:Environmental Pollutants; D007854:Lead; C579455:BDNF protein, human