title: Novel strategy for cystitis glandularis: Oral treatment with cyclooxygenase-2 inhibitor.
abstract: Cystitis glandularis, a proliferative disease of the bladder, is resistant to antibiotics, non-steroidal anti-inflammatory drugs, anti-allergy drugs and transurethral resection. Cystectomy or partial cystectomy is occasionally required for refractory cystitis glandularis. It has not been defined if cystitis glandularis is a premalignant lesion. We experienced a case of remission from cystitis glandularis after combination of oral treatment with selective cyclooxygenase-2 inhibitor, celecoxib and transurethral resection. Immunohistochemistry showed positive signals of cyclooxygenase-2 in the epithelium of pretreatment specimens, suggesting the pathophysiological role of cyclooxygenase-2 in cystitis glandularis. Here, we show the effectiveness of celecoxib against cystitis glandularis for the first time. Celecoxib could be one of the therapeutic strategies for cystitis glandularis.
authors.affiliation: Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Nae
authors.initials: N
authors.lastname: Takizawa
authors.affiliation: Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Matsuzaki
authors.affiliation: Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Teppei
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Mishima
authors.affiliation: Department of Pathology and Laboratory Medicine, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Chika
authors.initials: C
authors.lastname: Miyasaka
authors.affiliation: Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Kinoshita
authors.affiliation: Department of Pathology and Laboratory Medicine, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Uemura
authors.affiliation: Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Yamada
authors.affiliation: Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use*; D003556:Cystitis / Q000178:diet therapy*; D006801:Humans; D007150:Immunohistochemistry
chemical_list: D052246:Cyclooxygenase 2 Inhibitors
keywords: cyclooxygenase-2; cyclooxygenase-2 inhibitor; cystitis glandularis; intestinal metaplasia; intestinal type