title: Evaluation of [(89)Zr]-Oxalate as a PET Tracer in Inflammation, Tumor, and Rheumatoid Arthritis Models.
abstract: To obtain an additional pharmacological agent for the diagnosis of inflammation, we investigated the medical use of (89)Zr-oxalate as a positron emission tomography (PET) probe for the in vivo imaging of inflammation and compared its efficacy to that of 2-deoxy-2-[(18)F]fluoro-d-glucose ([(18)F]FDG) and sodium [(18)F]fluoride. (89)Zr-oxalate exhibited observable higher uptake in a macrophage cell line than in tumor cells. The inflammatory lesions and tumors were clearly visualized by PET imaging and autoradiography using (89)Zr-oxalate. Compared to [(18)F]FDG and sodium [(18)F]fluoride, (89)Zr-oxalate demonstrated a high selectivity index to the tumor at an early time point after injection and to inflammation at a delayed time point after injection (24 h). Through histological examination, large numbers of macrophages and neutrophils were observed in the tumor lesions with the highest (89)Zr-oxalate uptake. In a rheumatoid arthritis (RA) mouse model, (89)Zr-oxalate demonstrated a high level of accumulation in inflammatory lesions. (89)Zr-oxalate is a new strategic tool for tumor imaging and inflammatory processes.
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological & Medical Science , Seoul 139-706, Republic of Korea.
authors.forename: Ji-Ae
authors.initials: JA
authors.lastname: Park
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological & Medical Science , Seoul 139-706, Republic of Korea.
authors.forename: Yong Jin
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological & Medical Science , Seoul 139-706, Republic of Korea.
authors.forename: Ji Woong
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological & Medical Science , Seoul 139-706, Republic of Korea.
authors.forename: Ran Ji
authors.initials: RJ
authors.lastname: Yoo
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological & Medical Science , Seoul 139-706, Republic of Korea.
authors.forename: Un Chol
authors.initials: UC
authors.lastname: Shin
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological & Medical Science , Seoul 139-706, Republic of Korea.
authors.forename: Kyo Chul
authors.initials: KC
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences , Seoul 139-706, Republic of Korea.
authors.forename: Byung Il
authors.initials: BI
authors.lastname: Kim
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological & Medical Science , Seoul 139-706, Republic of Korea.
authors.forename: Kyeong Min
authors.initials: KM
authors.lastname: Kim
authors.affiliation: Molecular Imaging Research Center, Korea Institute of Radiological & Medical Science , Seoul 139-706, Republic of Korea.
authors.forename: Jung Young
authors.initials: JY
authors.lastname: Kim
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging*; D045744:Cell Line, Tumor; D019788:Fluorodeoxyglucose F18 / Q000032:analysis / Q000737:chemistry; D006801:Humans; D007249:Inflammation / Q000000981:diagnostic imaging*; D008297:Male; D051379:Mice; D010070:Oxalates / Q000032:analysis / Q000737:chemistry; D049268:Positron-Emission Tomography / Q000379:methods*; D000067996:RAW 264.7 Cells
chemical_list: D010070:Oxalates; D019788:Fluorodeoxyglucose F18
keywords: 89Zr-oxalate; PET; inflammation; rheumatoid arthritis; tumor