title: Endometrial thickness as a predictor of pregnancy outcomes in 10787 fresh IVF-ICSI cycles.
abstract: This retrospective study assessed the predictive value of endometrial thickness (EMT) on HCG administration day for the clinical outcome of fresh IVF and intracytoplasmic sperm injection (ICSI) cycles. A total of 8690 consecutive women undergoing 10,787 cycles over a 5-year period were included. The 5th, 50th and 95th centiles for EMT were determined as 8, 11 and 15 mm, respectively. Group analysis according to these centiles (Group 1: < 8 mm; Group 2: ≥ 8 and ≤11 mm; Group 3: > 11 and ≤15 mm; Group 4: > 15 mm) demonstrated significant differences (P < 0.001) in clinical pregnancy rates (23.0%, 37.2%, 46.2% and 53.3%, respectively), live birth rates per clinical pregnancy (63.3%, 72.0%, 78.1% and 80.3%, respectively), spontaneous abortion rates (26.7%, 23.8%, 19.9% and 17.5%, respectively), and ectopic pregnancy rates (10.0%, 4.3%, 2.1% and 2.2%, respectively). Logistic regression analyses showed EMT as one of the independent variables predictive of clinical pregnancy (OR = 1.097; P < 0.001), live birth (OR = 1.078; P < 0.001), spontaneous abortion (OR = 0.948; P < 0.001), and ectopic pregnancy (OR = 0.851; P < 0.001). Future research should aim to understand the underlying mechanisms relating EMT to conception, ectopic implantation and spontaneous abortion.
authors.affiliation: Reproductive Medicine Centre, Department of Obstetric and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Department of Obstetrics and Gynecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong; MOH Holdings Pte Ltd (MOHH), Singapore.
authors.forename: Xi
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Department of Obstetrics and Gynecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Sotirios H
authors.initials: SH
authors.lastname: Saravelos
authors.affiliation: Reproductive Medicine Centre, Department of Obstetric and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Reproductive Medicine Centre, Department of Obstetric and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Yanwen
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Obstetrics and Gynecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. Electronic address: tinchiu.li@cuhk.edu.hk.
authors.forename: Tin-Chiu
authors.initials: TC
authors.lastname: Li
authors.affiliation: Reproductive Medicine Centre, Department of Obstetric and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: zhoucanquan@hotmail.com.
authors.forename: Canquan
authors.initials: C
authors.lastname: Zhou
mesh_terms: D000022:Abortion, Spontaneous / Q000175:diagnosis; D000328:Adult; D006063:Chorionic Gonadotropin / Q000378:metabolism; D004717:Endometrium / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D050498:Live Birth; D008297:Male; D008423:Maternal Age; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012044:Regression Analysis; D012189:Retrospective Studies; D056826:Single Embryo Transfer; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*
chemical_list: D006063:Chorionic Gonadotropin
keywords: IVF–ICSI; clinical outcome; endometrial thickness; endometrium