title: [Nonstructural protein 1 of tick-borne encephalitis virus activates the expression of immunoproteasome subunits].
abstract: The interaction of viral proteins with host cell components plays an important role in antiviral immune response. One of the key steps of antiviral defense is the formation of immunoproteasomes. The effect of nonstructural protein 1 (NS1) of tick-borne encephalitis virus on the immunoproteasome formation was studied. It was shown that cell expression of NS1 does not reduce the efficacy of the immunoproteasome generation in response to interferon-γ stimulation and even increases the content of the immunoproteasome subunits without the interferon-γ treatment. Thus, NS1 of tick-borne encephalitis virus activates, rather than blocks the mechanisms of immune defense in the cell.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.|kuzmenko-yulia@mail.ru.
authors.forename: Y V
authors.initials: YV
authors.lastname: Kuzmenko
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
authors.forename: E S
authors.initials: ES
authors.lastname: Starodubova
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
authors.forename: G G
authors.initials: GG
authors.lastname: Karganova
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Timofeev
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia.
authors.forename: V L
authors.initials: VL
authors.lastname: Karpov
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology* / Q000472:pathogenicity; D004675:Encephalitis, Tick-Borne / Q000276:immunology* / Q000821:virology; D015967:Gene Expression Regulation, Viral; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000008:administration & dosage / Q000276:immunology; D046988:Proteasome Endopeptidase Complex / Q000276:immunology*; D017361:Viral Nonstructural Proteins / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000914:Antibodies, Viral; D017361:Viral Nonstructural Proteins; D007371:Interferon-gamma; D046988:Proteasome Endopeptidase Complex
keywords: immunoproteasome; nonstructural protein 1; tick-borne encephalitis virus