title: AAOS Research Symposium Updates and Consensus: Biologic Treatment of Orthopaedic Injuries.
abstract: Strategies that seek to enhance musculoskeletal tissue regeneration and repair by modulating the biologic microenvironment at the site of injury have considerable therapeutic potential. Current and emerging biologic approaches include the use of growth factors, platelet-rich plasma, stem cell therapy, and scaffolds. The American Academy of Orthopaedic Surgeons hosted a research symposium in November 2015 to review the current state-of-the-art biologic treatments of articular cartilage, muscle, tendon, and bone injuries and identify knowledge gaps related to these emerging treatments. This review outlines the findings of the symposium and summarizes the consensus reached on how best to advance research on biologic treatment of orthopaedic injuries.
authors.affiliation: From the Steadman Philippon Research Institute, Vail, CO (Dr. LaPrade), Stanford University, Redwood City, CA (Dr. Dragoo and Dr. Chu), NorthShore University HealthSystem, Chicago, IL (Dr. Koh), the University of Edinburgh, Edinburgh, United Kingdom (Dr. Murray), and Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI (Dr. Geeslin).
authors.forename: Robert F
authors.initials: RF
authors.lastname: LaPrade
authors.forename: Jason L
authors.initials: JL
authors.lastname: Dragoo
authors.forename: Jason L
authors.initials: JL
authors.lastname: Koh
authors.forename: Iain R
authors.initials: IR
authors.lastname: Murray
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Geeslin
authors.forename: Constance R
authors.initials: CR
authors.lastname: Chu
mesh_terms: D001688:Biological Products / Q000627:therapeutic use*; D002358:Cartilage, Articular / Q000293:injuries / Q000503:physiopathology; D003226:Congresses as Topic; D050723:Fractures, Bone / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D018482:Muscle, Skeletal / Q000293:injuries / Q000503:physiopathology; D012038:Regeneration / Q000187:drug effects*; D013708:Tendon Injuries / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D001688:Biological Products