title: The efficacy and safety of silodosin for the treatment of ureteral stones: a systematic review and meta-analysis.
abstract: BACKGROUND
  To evaluate the efficacy and safety of silodosin as a medical expulsive therapy for ureteral stones by means of a systematic review and meta-analysis.
  
  
  METHODS
  We searched MEDLINE, EMBASE and the Cochrane Controlled Trials Register to identify randomized controlled trials (RCTs) of silodosin in the treatment of ureteral stones. The reference lists of retrieved studies were also investigated.
  
  
  RESULTS
  Six RCTs, including 916 participants and comparing silodosin with controls, were used in the meta-analysis. Silodosin was superior to controls in terms of stone expulsion rate, the primary efficacy end point in all six RCTs (odds ratio [OR] for expulsion 2.16, 95 % confidence interval [CI] 1.62 to 2.86, p <0.00001). Silodosin was also more effective for secondary efficacy end points; the stone expulsion time (standardized mean difference [SMD] -3.66, 95 % CI -6.61 to -0.71; p =0.01) and analgesic requirements (SMD -0.89, 95 % CI -1.19 to -0.60; p < 0.00001) were significantly reduced compared with those of controls. Other than the incidence of abnormal ejaculation, which was higher in the silodosin groups (OR 2.84, 95 % CI 1.56 to 5.16, p =0.0006), few adverse effects were observed.
  
  
  CONCLUSIONS
  This meta-analysis indicates silodosin is an effective and safe treatment option for ureteral stones with a low occurrence of side effects.
authors.affiliation: Department of Urology, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, NO.20 East Yuhuangding Road, 264000, Yantai, China.
authors.forename: Diandong
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Urology, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, NO.20 East Yuhuangding Road, 264000, Yantai, China.
authors.forename: Jitao
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Urology, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, NO.20 East Yuhuangding Road, 264000, Yantai, China.
authors.forename: Hejia
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Department of Urology, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, NO.20 East Yuhuangding Road, 264000, Yantai, China. doctorcuiys@163.com.
authors.forename: Yuanshan
authors.initials: Y
authors.lastname: Cui
mesh_terms: D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D061686:Premature Ejaculation / Q000139:chemically induced / Q000453:epidemiology*; D015995:Prevalence; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D016896:Treatment Outcome; D053039:Ureterolithiasis / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D064804:Urological Agents / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D007211:Indoles; D064804:Urological Agents; C095285:silodosin
keywords: Meta-analysis; Randomized controlled trial; Silodosin; Ureteral stones