title: [An increase in the efficacy of psychopharmacotherapy of late-onset depressions: combination and substitution of antidepressants].
abstract: OBJECTIVE
  To comprehensively analyze the possibilities of using the methods of correction of non-effective psychopharmacotherapy of late-onset depressions.
  
  
  METHODS
  Methods of potentiating, combination and substitution of non-effective psychopharmacotherapy of late-onset depressions were studied.
  
  
  CONCLUSIONS
  Indications to the use and specific algorithms of substitution and addition of antidepressants in non-effective psychopharmacotherapy of late-onset depressions have been developed. These algorithms of combination therapy suggest the possibilities for choosing the individual combinations of antidepressants.
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Ivanets
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Kinkulkina
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: T I
authors.initials: TI
authors.lastname: Avdeeva
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: Yu G
authors.initials: YG
authors.lastname: Tikhonova
authors.affiliation: Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Luk'ianova
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy*; D057915:Drug Substitution; D005260:Female; D006801:Humans; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents