title: Over the river, through the woods: cognitive maps in the hippocampus and orbitofrontal cortex.
abstract: The hippocampus and the orbitofrontal cortex (OFC) both have important roles in cognitive processes such as learning, memory and decision making. Nevertheless, research on the OFC and hippocampus has proceeded largely independently, and little consideration has been given to the importance of interactions between these structures. Here, evidence is reviewed that the hippocampus and OFC encode parallel, but interactive, cognitive 'maps' that capture complex relationships between cues, actions, outcomes and other features of the environment. A better understanding of the interactions between the OFC and hippocampus is important for understanding the neural bases of flexible, goal-directed decision making.
authors.affiliation: Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Wikenheiser
authors.affiliation: Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA; the Department of Anatomy and Neurobiology, University of Maryland, Baltimore, Maryland 21201, USA; and the Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21205, USA.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Schoenbaum
mesh_terms: D000818:Animals; D003071:Cognition / Q000502:physiology*; D003657:Decision Making / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*