title: Metabolism, Metabolomics, and Nutritional Support of Patients with Sepsis.
abstract: Sepsis is characterized by profound changes in systemic and cellular metabolism that disrupt normal metabolic homeostasis. These metabolic changes can serve as biomarkers for disease severity. Lactate, a metabolite of anaerobic metabolism, is the most widely used ICU biomarker and it is incorporated into multiple management algorithms. Technological advances now make broader metabolic profiling possible, with early studies identifying metabolic changes associated with sepsis mortality. Finally, given the marked changes in metabolism in sepsis and the association of worse prognosis in patients with severe metabolic derangements, we summarize the seminal trials conducted to optimize nutrition in the ICU.
authors.affiliation: Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, 473 West 12th Avenue, Columbus, OH 43210, USA.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Englert
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Stanford University, 300 Pasteur Drive, H3143, Stanford, CA 94305-5236, USA. Electronic address: ajrogers@stanford.edu.
authors.forename: Angela J
authors.initials: AJ
authors.lastname: Rogers
mesh_terms: D015415:Biomarkers / Q000097:blood*; D006801:Humans; D055432:Metabolomics / Q000379:methods*; D018529:Nutritional Support / Q000379:methods*; D018805:Sepsis / Q000378:metabolism / Q000628:therapy*
chemical_list: D015415:Biomarkers
keywords: Biomarker; ICU outcomes; Metabolism; Metabolomics; Nutrition; Sepsis