title: Boy with central precocious puberty probably due to a peripheral cause.
abstract: A 6½ years Indian boy was brought by his parents, who were anxious about the excessive increase in the size of the boy's phallus, from the age of 2 years. On physical examination, the child had a penis length greater than the 97th centile for age, a sexual maturity rating of gonads at stage 2 and pubic hair at stage 3, with height in the high normal range (90-97th centile). The bone age was 12 years. Laboratory evaluation showed pubertal levels of testosterone and pubertal gonadotropin response to stimulation, confirming central precocious puberty (CPP). Incidentally, the hormonal profile also suggested congenital adrenal hyperplasia (CAH). This case report depicts a case of CPP probably caused by CAH in boys, which is rare.
authors.affiliation: Department of Endocrinology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India.
authors.forename: Pranab Kumar
authors.initials: PK
authors.lastname: Sahana
authors.affiliation: Department of Endocrinology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India.
authors.forename: Krishna Shankar
authors.identifier: http://orcid.org/0000-0001-6589-0487
authors.initials: KS
authors.lastname: Gopal Sankar
authors.affiliation: Department of Endocrinology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India.
authors.forename: Nilanjan
authors.initials: N
authors.lastname: Sengupta
authors.affiliation: Department of Endocrinology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India.
authors.forename: Kaustubh
authors.initials: K
authors.lastname: Chattopadhyay
mesh_terms: D000312:Adrenal Hyperplasia, Congenital / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D002648:Child; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007986:Luteinizing Hormone / Q000627:therapeutic use; D008297:Male; D011629:Puberty, Precocious / Q000000981:diagnostic imaging / Q000209:etiology*; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography
chemical_list: D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D006854:Hydrocortisone