title: Possible sertraline-induced extrapyramidal adverse effects in an adolescent.
abstract: Sertraline has been considered to be a relatively safe selective serotonin reuptake inhibitor for adolescents for a long time. We report herein a case of a 16-year-old Chinese boy with depression who experienced extrapyramidal-like effects, for example, facial spasm, upper limb dystonia, akathisia, and other disturbed behaviors, while being treated with sertraline 200 mg per day. His movement symptoms were significantly alleviated after the discontinuation of sertraline and the administration of scopolamine. This finding indicates that albeit infrequent, sertraline may cause severe extrapyramidal symptoms in adolescent patients, suggesting that clinicians should be alert to the neurological side effects of sertraline in young patients.
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Lian-Fang
authors.initials: LF
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Jin-Wen
authors.initials: JW
authors.lastname: Huang
authors.affiliation: Faculty of Clinical Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Si-Yang
authors.initials: SY
authors.lastname: Shan
authors.affiliation: Department of Psychology, University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Jia-Hong
authors.initials: JH
authors.lastname: Ding
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China; Faculty of Clinical Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Lai
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China; The Key Laboratory of Mental Disorder's Management in Zhejiang Province, National Clinical Research Center for Mental Health Disorders, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China; The Key Laboratory of Mental Disorder's Management in Zhejiang Province, National Clinical Research Center for Mental Health Disorders, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Hu
keywords: adolescents; extrapyramidal symptoms; selective serotonin reuptake inhibitors; sertraline