title: [Mechanism of Musk and Borneol on Inflammatory of Cerebral Ischemia and Reperfusion Injury at Different Time Points of Acute Phase in Rats].
abstract: OBJECTIVE
  To investigate the mechanism of Musk and Borneol on cerebral ischemia and reperfusion injury at different time points of acute phase in rats.
  
  
  METHODS
  180 rats were divided into seven groups including sham, ischemia-reperfusion after 24 h and 72 h model group, Musk 50 and 25 mg/kg groups, Borneol 50 and 25 mg/kg groups, and Xingnaojing 10 mL/kg group. Ischemia-reperfusion model was made after administration of each drug. The neurologic impairment scores at different time points after ischemia and reperfusion was evaluated, activities of cyclooxygenase (COX-2) and 5-lipoxygenase (5-LOX) in brain tissue were determined, and the expression of CysLT2 protein and mRNA in hippocampus were explored.
  
  
  RESULTS
  Musk and Borneol significantly improved the neurologic impairment scores of ischemia-reperfusion injury rats, improved the pathological morphology of rats brain tissue, reduced the activities of COX-2 and 5-LOX in brain homogenates,and inhibited the expression of CysLT2 protein in hippocampus.
  
  
  CONCLUSIONS
  Musk and Borneol have protective effect on inflammatory injury of acute injury in ischemia-reperfusion injury rats, the mechanism is related to inhibition the activity of COX-2 and 5-LOX in brain.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Cao
authors.forename: Tian
authors.initials: T
authors.lastname: Shen
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Ya-ling
authors.initials: YL
authors.lastname: Li
authors.forename: Chun-li
authors.initials: CL
authors.lastname: Cui
authors.forename: Zhi-shu
authors.initials: ZS
authors.lastname: Tang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D001921:Brain / Q000201:enzymology; D002545:Brain Ischemia / Q000188:drug therapy*; D001892:Camphanes / Q000494:pharmacology*; D051546:Cyclooxygenase 2 / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D001892:Camphanes; D005229:Fatty Acids, Monounsaturated; C008563:musk; D001094:Arachidonate 5-Lipoxygenase; D051546:Cyclooxygenase 2; C489691:Ptgs2 protein, rat; C022871:isoborneol