title: Metal organic frameworks mimicking natural enzymes: a structural and functional analogy.
abstract: In this review, we have portrayed the structure, synthesis and applications of a variety of biomimetic MOFs from an unprecedented angle. Synthetic MOF analogues of five distinct enzymes: phosphotriesterase, hydrogenase, cytochrome P450, chymotrypsin and carbonic anhydrase, have been discussed with their skeletal comparison to actual enzymatic active sites as reference, and an explanation of catalytic pathways from the mechanistic cycle of the corresponding enzymes is depicted. We demonstrated critically each of the five discrete situations by assimilating available benchmark researches in an attempt to provide a concise literature source on the ingenious design strategies and versatile biomimetic applications of this domain of materials.
authors.affiliation: Laboratory of Organometallics, Catalysis and Ordered Materials, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Center for Chemical and Material Engineering, Wuhan University of Technology, Wuhan 430070, China. Francis.verpoort@ugent.be and Department of Applied Chemistry, Faculty of Sciences, Wuhan University of Technology, Wuhan 430070, China.
authors.forename: Ipsita
authors.initials: I
authors.lastname: Nath
authors.affiliation: Laboratory of Organometallics, Catalysis and Ordered Materials, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Center for Chemical and Material Engineering, Wuhan University of Technology, Wuhan 430070, China. Francis.verpoort@ugent.be and Department of Applied Chemistry, Faculty of Sciences, Wuhan University of Technology, Wuhan 430070, China.
authors.forename: Jeet
authors.initials: J
authors.lastname: Chakraborty
authors.affiliation: Laboratory of Organometallics, Catalysis and Ordered Materials, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Center for Chemical and Material Engineering, Wuhan University of Technology, Wuhan 430070, China. Francis.verpoort@ugent.be and Department of Applied Chemistry, Faculty of Sciences, Wuhan University of Technology, Wuhan 430070, China and National Research Tomsk Polytechnic University, Lenin Avenue 30, Tomsk 634050, Russia and Ghent University Global Campus, 119 Songdomunhwa-Ro, Yeonsu-Gu, Songdo, Incheon 406-840, South Korea.
authors.forename: Francis
authors.initials: F
authors.lastname: Verpoort
mesh_terms: D032701:Biomimetics; D020134:Catalytic Domain; D002918:Chymotrypsin / Q000737:chemistry / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000378:metabolism; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism; D006418:Heme / Q000737:chemistry; D006864:Hydrogenase / Q000737:chemistry / Q000378:metabolism; D000073396:Metal-Organic Frameworks / Q000737:chemistry* / Q000378:metabolism; D044345:Phosphoric Triester Hydrolases / Q000737:chemistry / Q000378:metabolism
chemical_list: D004798:Enzymes; D000073396:Metal-Organic Frameworks; D006418:Heme; D003577:Cytochrome P-450 Enzyme System; D006864:Hydrogenase; D044345:Phosphoric Triester Hydrolases; D002918:Chymotrypsin