title: The Correlation Between 9p21 Chromosome rs4977574 Polymorphism Genotypes and the Development of Coronary Artery Heart Disease.
abstract: Our aim is to investigate the correlation between 9p21 chromosome rs4977574 polymorphism genotypes and the development of coronary artery heart disease (CHD). Two hundred and eighty-nine patients with angiography-confirmed CHD were recruited as the CHD group, while 338 subjects without CHD symptoms were enrolled as the control group. For all participating subjects, the genotypes of rs4977574 polymorphism were examined by the real-time PCR analysis. Analyses acquired from single-locus technique showed that genotype distribution of rs4977574 polymorphism was significantly different (p = 0.041) between CHD group and the control group. Logistic regression analysis demonstrated that rs4977574 polymorphism in a dominant mode significantly increased (p = 0.038) the risk of CHD, where odds ratio (OR) was 0.71 and the 95 % confidence interval (CI) 0.58-0.97 was applied. 9p21 chromosome rs4977574 polymorphism genotypes are associated with the incidence and development of CHD. The presence of C allele may reduce the risk of CHD.
authors.affiliation: Department of Cardiology, Second Hospital of Shaoxing, 141 Yan'an Road, Shaoxing, 312000, Zhejiang Province, China. 604266095@qq.com.
authors.forename: Oushan
authors.initials: O
authors.lastname: Tang
authors.affiliation: Department of Cardiology, Second Hospital of Shaoxing, 141 Yan'an Road, Shaoxing, 312000, Zhejiang Province, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Lv
authors.affiliation: Department of Cardiology, Second Hospital of Shaoxing, 141 Yan'an Road, Shaoxing, 312000, Zhejiang Province, China.
authors.forename: Yinhong
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Cardiology, Second Hospital of Shaoxing, 141 Yan'an Road, Shaoxing, 312000, Zhejiang Province, China.
authors.forename: Fengming
authors.initials: F
authors.lastname: Qin
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000235:genetics* / Q000517:prevention & control; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D065840:Protective Factors; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors
keywords: Coronary artery heart disease; Gene polymorphism; Glycosylated hemoglobin