title: Neoantigen activation, protein translocation and targeted drug delivery in combination with radiotherapy.
abstract: Concurrent chemo and radiation therapies are commonly used to treat locally advanced cancer. Despite improved efficacy, failure rates remain high due to healthy organ toxicity caused by chemo-radiotherapy. Recent technological advances such as nanoparticle encapsulation of anticancer agents, locally controlled irradiation and concurrent use of radio- and nano-medicines are providing innovative solutions for overcoming the limitations of systemic and local treatment toxicities. In this mini-review, we discuss the roles of radiotherapy in generating new therapeutic targets and altering the tumor microenvironment, and we propose their future applications in drug delivery in combination with radiotherapy.
authors.affiliation: Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74074, USA.
authors.forename: Sri Nandhini
authors.initials: SN
authors.lastname: Sethuraman
authors.affiliation: Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74074, USA.
authors.forename: Ashish
authors.initials: A
authors.lastname: Ranjan
mesh_terms: D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles; D009369:Neoplasms / Q000628:therapy*; D021381:Protein Transport; D011878:Radiotherapy; D059016:Tumor Microenvironment
chemical_list: D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents
keywords: neoantigen activation; radiation therapy; radiation triggered drug release