title: Disentangling the respective roles of the early environment and parental BMI on BMI change across childhood: A counterfactual analysis using the Millennium Cohort Study.
abstract: This study has two objectives. First, to analyse the respective roles of parental BMI and the wider environment on children's BMI across childhood, using a counterfactual analysis. Second, to determine if the correlations between parents and offspring BMI are partly environmental. We used data on 4437 girls and 4337 boys born in 2000-2001 in the UK and included in the Millennium Cohort Study. Children's BMI was measured at ages 3years, 5years, 7years, and 11years. We described the environment using social class and behaviours within the family. At the age of 3, there was no link between the environment and children's BMI. In contrast, there was a clear link between the environment and BMI slopes between 3 and 11years of age. At the age of 11, we calculated that if all children had the most favourable environment, mean BMI would be reduced by 0.91kg/m(2) (95% CI: 0.57-1.26) for boys and by 1.65kg/m(2) (95% CI: 1.28-2.02) for girls. Associations between parents' and offspring BMI remained unchanged after adjustment for environmental variables. Conversely, the link between the environment and children's BMI is partly reduced after adjustment for parental BMI. This confirms that parental BMI is partly a broad proxy of the environment. We highlighted that if every child's environment was at its most favourable, the mean BMI would be significantly reduced. Thus, the recent rise is likely to be reversible.
authors.affiliation: INSERM, UMR1027, F-31000 Toulouse, France; Université Toulouse III Paul-Sabatier, UMR1027, F-31000 Toulouse, France. Electronic address: rom.fantin@wanadoo.fr.
authors.forename: Romain
authors.initials: R
authors.lastname: Fantin
authors.affiliation: INSERM, UMR1027, F-31000 Toulouse, France; Université Toulouse III Paul-Sabatier, UMR1027, F-31000 Toulouse, France.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Delpierre
authors.affiliation: INSERM, UMR1027, F-31000 Toulouse, France; Université Toulouse III Paul-Sabatier, UMR1027, F-31000 Toulouse, France; Department of Epidemiology, Health Economics and Public Health Toulouse University Hospital, Toulouse, France.
authors.forename: Chloé
authors.initials: C
authors.lastname: Dimeglio
authors.affiliation: INSERM, UMR1027, F-31000 Toulouse, France; Université Toulouse III Paul-Sabatier, UMR1027, F-31000 Toulouse, France; Department of Clinical Pharmacology, Toulouse University Hospital, Toulouse, France; Department of Epidemiology, Health Economics and Public Health Toulouse University Hospital, Toulouse, France.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Lamy
authors.affiliation: INSERM, UMR1027, F-31000 Toulouse, France; Université Toulouse III Paul-Sabatier, UMR1027, F-31000 Toulouse, France; Universidad de Costa Rica, 2060 San José, Costa Rica.
authors.forename: Cristina
authors.initials: C
authors.lastname: Barboza Solís
authors.affiliation: INSERM, UMR 1153 (CRESS), Paris Descartes University, Villejuif, France.
authors.forename: Marie-Aline
authors.initials: MA
authors.lastname: Charles
authors.affiliation: INSERM, UMR1027, F-31000 Toulouse, France; Université Toulouse III Paul-Sabatier, UMR1027, F-31000 Toulouse, France.
authors.forename: Michelle
authors.initials: M
authors.lastname: Kelly-Irving
mesh_terms: D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004777:Environment; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000517:prevention & control; D010290:Parents; D012307:Risk Factors; D011795:Surveys and Questionnaires; D006113:United Kingdom
keywords: BMI; Childhood; Counterfactual analysis; Environment; Parental BMI; Public health