title: Health-Related Quality of Life of Kidney Transplantation Patients: Results from the KoreaN Cohort Study for Outcome in Patients With Kidney Transplantation (KNOW-KT) Study.
abstract: BACKGROUND
  As patient and graft survival rates have been improving after kidney transplantation, health-related quality of life (HR-QOL) has become an important indicator of effective treatment. This study aimed to evaluate changes in HR-QOL after kidney transplantation.
  
  
  METHODS
  The KoreaN cohort study for Outcome in patients With Kidney Transplantation (KNOW-KT) is a multicenter, observational, 9-year, cohort study. The HR-QOL of patients in the KNOW-KT study was assessed before transplantation and 2 years after transplantation using the Kidney Disease Quality of Life Short Form (KDQOL-SF) including chronic kidney disease targeted area and the Medical Outcome Study 36-item Short Form Health Survey (SF-36). Multivariate linear regression was used to identify significant factors associated with follow-up QOL scores.
  
  
  RESULTS
  A total of 175 patients from 8 centers were analyzed. All QOL scores including the total QOL score, chronic kidney disease targeted score, and SF-36 at the 2-year follow-up were significantly increased compared to baseline values. Both physical and mental scale scores were improved after transplantation.
  
  
  CONCLUSIONS
  The QOL scores for both the mental and physical scales were improved at 2 years after kidney transplantation. High glomerular filtration rate at 2 years, high baseline QOL score, and low body mass index were associated with good follow-up QOL scores. Kidney transplantation for an Asian population with end-stage renal disease can result in better QOL as well as better patient and graft survival.
authors.affiliation: Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea.
authors.forename: H J
authors.initials: HJ
authors.lastname: Lim
authors.affiliation: Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea.
authors.forename: T Y
authors.initials: TY
authors.lastname: Koo
authors.affiliation: Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea.
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Transplantation Surgery, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Huh
authors.affiliation: Department of Surgery, Sungkyunkwan University, Seoul Samsung Medical Center, Seoul, Republic of Korea.
authors.forename: J B
authors.initials: JB
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Kyungpook National University Hospital, Seoul, Republic of Korea.
authors.forename: J
authors.initials: J
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Chonbuk National University Hospital, Seoul, Republic of Korea.
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Gachon University, Gil Hospital, Seoul, Republic of Korea.
authors.forename: H
authors.initials: H
authors.lastname: Ro
authors.affiliation: Department of Internal Medicine, Keimyung University, Dongsan Medical Center, Seoul, Republic of Korea.
authors.forename: S
authors.initials: S
authors.lastname: Han
authors.affiliation: Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: B
authors.initials: B
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Keimyung University, Dongsan Medical Center, Seoul, Republic of Korea.
authors.forename: S
authors.initials: S
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Gachon University, Gil Hospital, Seoul, Republic of Korea.
authors.forename: W
authors.initials: W
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Chonbuk National University Hospital, Seoul, Republic of Korea.
authors.forename: S K
authors.initials: SK
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Kyungpook National University Hospital, Seoul, Republic of Korea.
authors.forename: C
authors.initials: C
authors.lastname: Kim
authors.affiliation: Department of Surgery, Sungkyunkwan University, Seoul Samsung Medical Center, Seoul, Republic of Korea.
authors.forename: S J
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Transplantation Surgery, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea.
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: C
authors.initials: C
authors.lastname: Ahn
authors.affiliation: Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address: jcyjs@dreamwiz.com.
authors.forename: J
authors.initials: J
authors.lastname: Yang
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D056910:Republic of Korea; D055815:Young Adult