title: Epidemiology of dementia and its burden in the city of Kolkata, India.
abstract: Increase in aging population is expected to lead to increasing prevalence of dementia in India. In this study, we aimed to determine prevalence, incidence, and mortality of dementia and its subtypes and assess dementia burden in terms of disability-adjusted life years (DALY).
  
  
  
  A community study was conducted over 5 years (2003-2008) in Kolkata, India, on 100,802 (males 53,209) randomly selected subjects to assess prevalence and capture data on incident cases and deaths. Standard case definitions were used. The data were used to estimate years of life lost (YLL) due to premature mortality, years of life lived with disability (YLD), and DALY, based on Global Burden of Disease 2010 approach.
  
  
  
  During 2003-2004, there were 103 (men 55) cases of dementia. The prevalence was 1.53% (age adjusted 1.12%) at age ≥65 years. In those ≥55 years age, average annual incidence rate of dementia was 72.57 per 100,000. All-cause standardized mortality ratio in dementia cases was 4.74 (men 6.19, women 3.03). The burden of dementia in 2007-2008 revealed that overall YLL was 47.13 per 100,000 and YLD ranged from 1.87 to 16.95 per 100,000 depending on the clinical severity of dementia. The overall DALY lost per 100,000 due to dementia for the year 2007-2008 was 74.19.
  
  
  
  This community study revealed a low prevalence and incidence of dementia with consequent low DALY-derived burden of illness compared with many industrialized nations. YLL formed major component of DALY indicating premature mortality to be an outcome of dementia burden. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Neurology, National Neuroscience Centre, Kolkata, India.
authors.forename: Tapas Kumar
authors.initials: TK
authors.lastname: Banerjee
authors.affiliation: Department of Statistics, University of Calcutta Ballygunj Campus, Kolkata, India.
authors.forename: Saunak
authors.initials: S
authors.lastname: Dutta
authors.affiliation: Department of Neurology, Bangur Institute of Neurosciences, Kolkata, India.
authors.forename: Sujata
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Psychiatry, Medical College Kolkata, Kolkata, India.
authors.forename: Malay
authors.initials: M
authors.lastname: Ghosal
authors.affiliation: Department of Neurology, R. G. Kar Medical College, Kolkata, India.
authors.forename: Biman Kanti
authors.initials: BK
authors.lastname: Ray
authors.affiliation: Department of Neurology, Bangur Institute of Neurosciences, Kolkata, India.
authors.forename: Atanu
authors.initials: A
authors.lastname: Biswas
authors.affiliation: Department of Pharmacology, Institute of Post Graduate Medical Education and Research (IPGME&R), Kolkata, India.
authors.forename: Avijit
authors.initials: A
authors.lastname: Hazra
authors.affiliation: Sampling Unit, Department of Applied Statistics, Indian Statistical Institute, Kolkata, India.
authors.forename: Arijit
authors.initials: A
authors.lastname: Chaudhuri
authors.affiliation: Department of psychiatry, ICARE Institute of Medical Sciences & Research, Haldia, West Bengal, India.
authors.forename: Neelanjana
authors.initials: N
authors.lastname: Paul
authors.affiliation: Department of Neurology, Bangur Institute of Neurosciences, Kolkata, India.
authors.forename: Shyamal Kumar
authors.initials: SK
authors.lastname: Das
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D017281:Cost of Illness; D003704:Dementia / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D019057:Quality-Adjusted Life Years
keywords: dementia; disability-adjusted life years (DALY); incidence; mortality; prevalence