title: Chorangiosis of Chorionic Villi: What Does It Really Mean?
abstract: BACKGROUND
  -Chorangiosis has been regarded as a result of low-grade placental hypoxia associated with pregnancy risk factors and abnormal outcomes. It is unknown whether these are a consequence of chorangiosis itself or of associated other placental pathology.
  
  
  OBJECTIVE
  -To prove that chorangiosis itself does not portend an increased risk for pregnancy unless associated with other placental pathology.
  
  
  METHODS
  -This retrospective statistical study analyzes 1231 consecutive placentas with diffuse or focal hypervascularity of chorionic villi: 328 with preuterine pattern of chronic hypoxic placental injury (group 1), 297 with uterine type of chronic hypoxic placental injury (group 2), and 606 cases with chorangiosis (group 3) not fulfilling the inclusion criteria for groups 1 or 2.
  
  
  RESULTS
  -Group 2, with 33 cases of chorangiosis (11.1%), featured 10 and 11 statistically significant highest percentages of abnormal clinical and placental variables, respectively; group 3 featured the highest percentages of multiple pregnancy, the heaviest placentas, and the most common acute chorioamnionitis, fetal inflammatory response; and group 1 had the highest proportion of mild erythroblastosis of fetal blood. When comparing groups 1 and 3, 21 of 29 clinical risk factors/outcomes (72.4%) and 30 of 41 placental variables (73.2%) were more common in group 1.
  
  
  CONCLUSIONS
  -Presence of diffuse hypoxic patterns of placental injury adds prognostically negative significance to increased vascularity of chorionic villi. Chorangiosis without those patterns portends minimal risk for the pregnancy, and is associated with significantly fewer pregnancy risk factors, abnormal outcomes, and other placental abnormalities.
authors.affiliation: From the Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Stanek
mesh_terms: D002824:Chorionic Villi / Q000473:pathology*; D016208:Databases, Factual; D005260:Female; D005311:Fetal Hypoxia / Q000473:pathology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000473:pathology*; D010920:Placenta / Q000473:pathology*; D010922:Placenta Diseases / Q000473:pathology*; D011247:Pregnancy; D012189:Retrospective Studies