title: A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins.
abstract: Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes.
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, 210095 Nanjing, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), 210095 Nanjing, China.
authors.forename: Maofeng
authors.initials: M
authors.lastname: Jing
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, 210095 Nanjing, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), 210095 Nanjing, China.
authors.forename: Baodian
authors.initials: B
authors.lastname: Guo
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, 210095 Nanjing, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), 210095 Nanjing, China.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, 210095 Nanjing, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), 210095 Nanjing, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, 210095 Nanjing, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), 210095 Nanjing, China.
authors.forename: Haonan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, 210095 Nanjing, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), 210095 Nanjing, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Kong
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, 210095 Nanjing, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), 210095 Nanjing, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, 210095 Nanjing, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), 210095 Nanjing, China.
authors.forename: Huawei
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, 210095 Nanjing, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), 210095 Nanjing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, 210095 Nanjing, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), 210095 Nanjing, China.
authors.forename: Wenwu
authors.identifier: 0000-0001-7347-8935
authors.initials: W
authors.lastname: Ye
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, 210095 Nanjing, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), 210095 Nanjing, China.
authors.forename: Suomeng
authors.initials: S
authors.lastname: Dong
authors.affiliation: Institute of Crop Science, Chinese Academy of Agricultural Sciences, 100081 Beijing, China.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: Center for Genome Research and Biocomputing and Department of Botany and Plant Pathology, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: Brett M
authors.initials: BM
authors.lastname: Tyler
authors.affiliation: Department of Plant Pathology and Microbiology, University of California, Riverside, California 92521, USA.|Center for Plant Cell Biology, University of California, Riverside, California 92521, USA.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Ma
authors.affiliation: Department of Plant Pathology, Nanjing Agricultural University, 210095 Nanjing, China.|Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), 210095 Nanjing, China.
authors.forename: Yuanchao
authors.identifier: 0000-0001-5803-5343
authors.initials: Y
authors.lastname: Wang
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism*; D016923:Cell Death / Q000276:immunology*; D059865:Endoplasmic Reticulum Stress / Q000276:immunology*; D007136:Immunoglobulins / Q000276:immunology* / Q000378:metabolism; D010838:Phytophthora / Q000378:metabolism*; D010935:Plant Diseases / Q000276:immunology*; D057865:Plant Immunity / Q000276:immunology*; D010940:Plant Proteins / Q000378:metabolism*; D013025:Glycine max / Q000276:immunology / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D007136:Immunoglobulins; D010940:Plant Proteins