title: [Clinical burden caused by hospitalization for febrile neutropenia in France in 2010-2011: An analysis of the PMSI database].
abstract: BACKGROUND
  Febrile neutropenia (FN) is a severe complication of chemotherapy in terms of morbidity and mortality. Using data from the PMSI database, the objective of this work was to estimate the clinical burden caused by hospitalization for FN in France, assessed by number of patients, number of stays and hospital mortality.
  
  
  METHODS
  Using the PMSI database (which includes all hospitalizations occurring annually in France), an algorithm was used to select newly-diagnosed patients treated by chemotherapy in 2010/2011 who were hospitalized for FN within the 30 days following each administration of chemotherapy during their first year of treatment. The number, characteristics and comorbidities of patients were described, as well as the number and length of stay and mortality in hospitalized patients.
  
  
  RESULTS
  In 2010-11, 10,229 patients were hospitalized for FN, representing a hospitalization rate of 7.4% in newly-diagnosed patients receiving chemotherapy. A total of 13,559 stays were identified, with an average duration of 6.3±8.7 days (median=4 days). A total of 720 deaths occurred during the hospital stays, corresponding to a mortality rate of 7%. Among patients hospitalized for FN, there were 14% of patients with diabetes, 8 % with heart failure, 34% with hypertension and 41% with at least one of these three comorbidities.
  
  
  CONCLUSIONS
  With 10,299 hospitalized patients and 13,559 stays in 2010-11, the clinical burden induced by febrile neutropenia in cancer patients treated with chemotherapy is considerable.
authors.affiliation: Institut de cancérologie des hospices civils de Lyon, service d'oncologie médicale, 69495 Lyon, France; Université de Lyon, EMR 3738, 69495 Lyon, France. Electronic address: gilles.freyer@univ-lyon1.fr.
authors.forename: Gilles
authors.initials: G
authors.lastname: Freyer
authors.affiliation: Hôpital européen Georges-Pompidou, unité fonctionnelle de soins oncologiques de support et oncologie médicale, 75015 Paris, France.
authors.forename: Florian
authors.initials: F
authors.lastname: Scotte
authors.affiliation: Université Paris-Saclay, Univ. Paris-Sud, CESP Oncostat, INSERM 1018, 94805 Villejuif, France; GRADES, Université Paris-Sud, Université Paris-Saclay, 5 rue Jean-Baptiste Clément, 92290 Châtenay-Malabry, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Borget
authors.affiliation: Institut de cancérologie des hospices civils de Lyon, service d'oncologie médicale, 69495 Lyon, France; Université de Lyon, EMR 3738, 69495 Lyon, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Bruyas
authors.affiliation: HEVA, 69495 Lyon, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Vainchtock
authors.affiliation: Centre hospitalier intercommunal de Créteil, service de pneumologie, 94000 Créteil, France; Université Paris-Est Créteil, 94000 Créteil, France.
authors.forename: Christos
authors.initials: C
authors.lastname: Chouaid
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D064147:Febrile Neutropenia / Q000139:chemically induced / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D005602:France / Q000453:epidemiology; D017052:Hospital Mortality; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*; D017678:Sex Distribution
keywords: Base PMSI; Clinical burden; Febrile neutropenia; Hospitalisation; Hospitalization; Impact clinique; Neutropénie fébrile; PMSI database