title: RNA Dynamics in the Control of Circadian Rhythm.
abstract: The circadian oscillator is based on transcription-translation feedback loops that generate 24 h oscillations in gene expression. Although circadian regulation of mRNA expression at the transcriptional level is one of the most important steps for the generation of circadian rhythms within the cell, multiple lines of evidence point to a disconnect between transcript oscillation and protein oscillation. This can be explained by regulatory RNA-binding proteins acting on the nascent transcripts to modulate their processing, export, translation and degradation rates. In this chapter we will review what is known about the different steps involved in circadian gene expression from transcription initiation to mRNA stability and translation efficiency. The role of ribonucleoprotein particles in the generation of rhythmic gene expression is only starting to be elucidated, but it is likely that they cooperate with the basal transcriptional machinery to help to maintain the precision of the clock under diverse cellular and environmental conditions.
authors.affiliation: Institute of Pharmacology and Toxicology, University of Zürich, Winterthurerstrasse 190, Zürich, 8057, Switzerland.|Salk Institute for Biological Studies, 10010, North Torrey Pines Road, La Jolla, CA, 92037, USA.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Benegiamo
authors.affiliation: Institute of Pharmacology and Toxicology, University of Zürich, Winterthurerstrasse 190, Zürich, 8057, Switzerland.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Brown
authors.affiliation: Salk Institute for Biological Studies, 10010, North Torrey Pines Road, La Jolla, CA, 92037, USA. satchin@salk.edu.
authors.forename: Satchidananda
authors.initials: S
authors.lastname: Panda
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D005091:Exons; D005786:Gene Expression Regulation; D006801:Humans; D001678:Organelle Biogenesis; D012313:RNA / Q000096:biosynthesis / Q000502:physiology*; D012323:RNA Processing, Post-Transcriptional; D012326:RNA Splicing; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D012270:Ribosomes / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D012313:RNA
keywords: Chromatin modifications; Exon array; IRES; Nascent-seq; PolyA tail length; RNA-seq; RNAPII; Ribosome; eRNA