title: The Current Situation on Major Depressive Disorder in China: Research on Mechanisms and Clinical Practice.
abstract: Depression is the most disabling disorder worldwide that accounts for the highest proportion of global burden attributable to mental disorders. Major depressive disorder (MDD) is characterized by deep sadness, reduced energy, vegetative nervous system dysregulation, cognitive dysfunction, and even a high suicidal tendency. Although other treatment choices are available, antidepressant medication is the front-line treatment option for MDD. Regarding clinical efficacy, only ~50% of patients respond to frontline antidepressants, and <33% obtain remission. Currently, objective indexes to guide clinical decisions are still lacking. Furthermore, knowledge about the neurobiological mechanisms underlying discrepant antidepressant outcomes is still also fragmentary. In the present review, we discuss the current research progress and clinical opinions on MDD in China.
authors.affiliation: Department of Psychosomatics and Psychiatry, Institute of Psychosomatic Medicine, Zhongda Hospital, Medical School of Southeast University, Nanjing, 210009, China.
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Hou
authors.affiliation: Department of Psychosomatics and Psychiatry, Institute of Psychosomatic Medicine, Zhongda Hospital, Medical School of Southeast University, Nanjing, 210009, China.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Psychosomatics and Psychiatry, Institute of Psychosomatic Medicine, Zhongda Hospital, Medical School of Southeast University, Nanjing, 210009, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Department of Neurology, Institute of Neuropsychiatry, Zhongda Hospital, Medical School of Southeast University, Nanjing, 210009, China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Psychosomatics and Psychiatry, Institute of Psychosomatic Medicine, Zhongda Hospital, Medical School of Southeast University, Nanjing, 210009, China. yygylh2000@sina.com.
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D002681:China / Q000453:epidemiology; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D020399:Practice Management / Q000706:statistics & numerical data; D012106:Research
keywords: Antidepressant; Biomarker; China; Epidemiology; Major depressive disorder; Pathogenesis