title: Baclofen Toxicity Causing Acute, Reversible Dyskinesia.
abstract: The following unique case demonstrates an episode of acute dyskinesia secondary to oral baclofen toxicity. We discuss an 80-year-old man with a history of Stage III chronic kidney disease, coronary artery disease, diabetes and stroke who presented to the Emergency Department with new onset of behavioral changes and irregular jerking movements. The patient had been recently prescribed baclofen 10mg twice daily for a back strain he suffered; he subsequently was admitted to the hospital, and his symptoms resolved within 48 hours of admission and discontinuance of baclofen.
authors.affiliation: Department of Emergency Medicine, Lehigh Valley Health Network, Cedar Crest Boulevard & I-78, Allentown, PA, 18103, USA.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Niehaus
authors.affiliation: Department of Emergency Medicine, Lehigh Valley Health Network, Cedar Crest Boulevard & I-78, Allentown, PA, 18103, USA.
authors.forename: Nicole C
authors.initials: NC
authors.lastname: Elliott
authors.affiliation: Department of Emergency Medicine, Lehigh Valley Health Network, Cedar Crest Boulevard & I-78, Allentown, PA, 18103, USA. Kenneth_D.Katz@lvhn.org.|Lehigh Valley Health Network, EM Research, 4th Floor, South Wing, 2545 Schoenersville Road, Bethlehem, PA, 18017, USA. Kenneth_D.Katz@lvhn.org.
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Katz
mesh_terms: D000369:Aged, 80 and over; D001416:Back Pain / Q000150:complications / Q000188:drug therapy*; D001418:Baclofen / Q000097:blood / Q000627:therapeutic use / Q000633:toxicity*; D003324:Coronary Artery Disease / Q000188:drug therapy; D003920:Diabetes Mellitus / Q000188:drug therapy; D004347:Drug Interactions; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D005919:Glomerular Filtration Rate; D006801:Humans; D007902:Length of Stay; D008297:Male; D009125:Muscle Relaxants, Central / Q000627:therapeutic use / Q000633:toxicity*; D019338:Polypharmacy; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy; D020521:Stroke / Q000188:drug therapy
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen
keywords: Acute dyskinesia; Neurologic adverse effects; Oral baclofen toxicity; Reduced GFR