title: Asymmetric axonal edge guidance: a new paradigm for building oriented neuronal networks.
abstract: We present a novel kind of directional axon guides for brain-on-a-chip applications. Contrarily to previous works, the directionality in our design is created by rerouting axons growing in the unwanted direction back to their original compartment while leaving the other growth direction unaffected. This design yields state-of-the-art levels of directionality without the disadvantages of previously reported technologies.
authors.affiliation: UMR 168 Physico-Chimie Curie, CNRS, PSL Research University, Institut Curie, 75005, Paris, France. catherine.villard@curie.fr.
authors.forename: Renaud
authors.initials: R
authors.lastname: Renault
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Durand
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Viovy
authors.forename: Catherine
authors.initials: C
authors.lastname: Villard
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D003585:Cell Biology / Q000295:instrumentation*; D005453:Fluorescence; D056656:Lab-On-A-Chip Devices; D008822:Mice, Transgenic; D009415:Nerve Net / Q000502:physiology*