title: Safety and Efficacy of Autologous Plasma Rich in Growth Factors Eye Drops for the Treatment of Evaporative Dry Eye.
abstract: OBJECTIVE
  To provide preliminary information about the safety and efficacy of plasma rich in growth factors (PRGF) in the treatment of evaporative dry eye (EDE) and analyze the influence of certain variables on treatment outcomes.
  
  
  METHODS
  This retrospective study included patients with EDE treated between January 2011 and December 2013. Outcome measures including signs and symptoms of the disease were evaluated before and after treatment. The influence of some of the patient's clinical variables on results was assessed. Safety assessment was also performed.
  
  
  RESULTS
  Eighty-three patients with a total of 156 eyes were evaluated. Statistically significant reductions in the Ocular Surface Disease Index (38.2%), best-corrected visual acuity (27.4%), Visual Analogue Scale scores for frequency (32%) and severity (34%), and a significant improvement in the Schirmer test scores (177.5%) were observed (p < 0.05). The results were stratified according to the identified potential effect modifiers. Only four adverse events were reported. All of them were mild and resolved within a few days.
  
  
  CONCLUSIONS
  Results suggest that PRGF eye drops could be a safe and effective treatment in reducing EDE signs and symptoms. When treating patients, the possible influence of some clinical variables must be taken into account.
authors.affiliation: Instituto Universitario Fernx00E1;ndez-Vega, Fundacix00F3;n de Investigacix00F3;n Oftalmolx00F3;gica, Universidad de Oviedo, Oviedo, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Merayo-Lloves
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Sanchez-Avila
authors.forename: Ana C
authors.initials: AC
authors.lastname: Riestra
authors.forename: Eduardo
authors.initials: E
authors.lastname: Anitua
authors.forename: Leire
authors.initials: L
authors.lastname: Begoña
authors.forename: Gorka
authors.initials: G
authors.lastname: Orive
authors.forename: Luis
authors.initials: L
authors.lastname: Fernandez-Vega
mesh_terms: D000293:Adolescent; D000328:Adult; D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010949:Plasma; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D009883:Ophthalmic Solutions