title: Aromatase inhibitors and anti-synthetase syndrome.
abstract: Adjuvant therapy in postmenopausal women with endocrine-responsive breast cancer (BC) is actually centered on the use of anti-aromatase inhibitors (AI). Several reports, however, are emerging in literature associating the use of this drugs to rheumatic disorders. This case report describes the first case of anti-synthetase syndrome diagnosis after treatment with anti-estrogen agents in a patient with pre-existing rheumatoid arthritis.
authors.affiliation: Internal Medicine and Rheumatology, Ospedale degli Infermi, Rimini, Azienda Sanitaria della Romagna, Italy fabiomascella@hotmail.com.
authors.forename: Fabio
authors.initials: F
authors.lastname: Mascella
authors.affiliation: Oncology Department, Ospedale degli Infermi, Azienda Sanitaria della Romagna, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Gianni
authors.affiliation: Oncology Department, Ospedale degli Infermi, Azienda Sanitaria della Romagna, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Affatato
authors.affiliation: Oncology Department, Ospedale degli Infermi, Azienda Sanitaria della Romagna, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Fantini
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000378:metabolism; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D017024:Chemotherapy, Adjuvant / Q000379:methods; D005260:Female; D006801:Humans; D008025:Ligases / Q000037:antagonists & inhibitors*; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism; D013577:Syndrome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D011960:Receptors, Estrogen; D008025:Ligases
keywords: anti-synthetase syndrome; aromatase inhibitors; rheumatoid arthritis