title: Health-related quality of life in adolescent survivors of bronchopulmonary dysplasia.
abstract: Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease of infancy in the developed countries. Outcomes for BPD patients have traditionally been assessed using physiological parameters such as lung function, and no data are available on the health-related quality of life (HRQOL) for adolescents with BPD. The aim of this study was to assess HRQOL in adolescents with BPD, in comparison with age-matched and sex-matched control groups of healthy volunteers and asthmatic subjects.
  
  
  
  We enrolled 27 BPD patients (age range 11-19 years), 27 asthmatic patients and 27 healthy controls. HRQOL was assessed by the Short Form 36 (SF-36) questionnaire. Lung function was assessed by spirometry.
  
  
  
  The BPD group did not differ significantly from the healthy controls in any scale or dimension of the SF-36 (the BPD group's summary scores were as follows: physical component summary mean 55.6 + 4.98 and mental component summary 51.8 + 7.75 vs 55.8 + 6.25 and 49.2 + 9.45 for the healthy control group, P > 0.5 and P = 0.26, respectively). Asthmatic adolescents scored lower than those of both healthy controls and patients with BPD in several SF-36 dimensions despite adolescents with BPD having lower lung function. No correlation emerged between lung function and HRQOL in BPD subjects.
  
  
  
  Despite their impaired lung function, BPD patients have an HRQOL comparable with healthy peers and better than asthmatic patients. We did not find any association between HRQOL and lung function parameters.
authors.affiliation: Unit of Pediatric Respiratory Medicine and Allergy, Women's and Children's Health Department, University of Padova, Padova, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Bozzetto
authors.affiliation: Unit of Pediatric Respiratory Medicine and Allergy, Women's and Children's Health Department, University of Padova, Padova, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Carraro
authors.affiliation: Unit of Pediatric Respiratory Medicine and Allergy, Women's and Children's Health Department, University of Padova, Padova, Italy.
authors.forename: Lisanna
authors.initials: L
authors.lastname: Tomasi
authors.affiliation: Unit of Pediatric Respiratory Medicine and Allergy, Women's and Children's Health Department, University of Padova, Padova, Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Berardi
authors.affiliation: Unit of Pediatric Respiratory Medicine and Allergy, Women's and Children's Health Department, University of Padova, Padova, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Zanconato
authors.affiliation: Unit of Pediatric Respiratory Medicine and Allergy, Women's and Children's Health Department, University of Padova, Padova, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Baraldi
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology*; D001997:Bronchopulmonary Dysplasia / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D011788:Quality of Life; D013147:Spirometry / Q000379:methods; D011795:Surveys and Questionnaires; D017741:Survivors / Q000523:psychology*
keywords: Short Form 36 questionnaire; asthma; bronchopulmonary dysplasia; health-related quality of life; paediatrics