title: [The correlation between testosterone levels and C-reactive protein in acute bacterial epididymo-orchitis].
abstract: Acute bacterial epididymo-orchitis is common urological condition that usually originates from ascending infection of lower urinary tract. It is characterized by infection of testis combined with spermatogenesis and steroidogenesis impairment. There is also a component of local and systemic inflammation.
  
  
  OBJECTIVE
  The aim of this study was to assess the effect of systemic inflammation associated with acute epididymo-orchitis on testis steroidogenesis.
  
  
  METHODS
  30 patients with acute bacterial epididymoorchitis treated in our ward without any oncologic involvement or other systemic inflammatory conditions were considered for the study. Total serum levels of testosterone and C-reactive protein measured within 12 hours of admission.
  
  
  RESULTS
  Low total testosterone levels regarding to random laboratory population norms were noticed in 11 patients. Diminished serum total testosterone levels regarding to medium age levels were identified in 24 patients (80%). 29 patients had serum CRP levels elevated what gives average 22x fold. There is a statistically significant negative correlation between serum total testosterone levels and CRP serum levels were found (R - 0.75; p<0.000002 Spearman's correlation).
  
  
  CONCLUSIONS
  There is a strong influence of ongoing systemic inflammation caused by bacterial infection on steroidogenesis in testis in acute epididymo-orchitis patients.
authors.affiliation: Pabianice Medcial Center - Urological Department; Medical University of Lodz - Department of Histology and Embryology, Interdepartmental Chair of Anatomy and Histology.
authors.forename: Wiktor
authors.initials: W
authors.lastname: Kępa
authors.affiliation: Pabianice Medcial Center - Urological Department.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Krzyżanowski
authors.affiliation: Feinstein Institute for Medical Research Northwell Health - Manhasset, New York.
authors.forename: Sonu
authors.initials: S
authors.lastname: Sahni
authors.affiliation: Medical University of Lodz - Department of Histology and Embryology, Interdepartmental Chair of Anatomy and Histology.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Zieliński
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D004823:Epididymitis / Q000097:blood* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009920:Orchitis / Q000097:blood* / Q000382:microbiology; D013739:Testosterone / Q000096:biosynthesis / Q000097:blood*
chemical_list: D013739:Testosterone; D002097:C-Reactive Protein
keywords: C-Reactive protein; Testis; Testosterone; Urinary Tract Infection; epididymo-orchitis