title: Coeliac disease in the elderly in a tertiary centre.
abstract: OBJECTIVE
  Coeliac disease (CD) was believed to be a childhood disease while it can affect any age.
  
  
  OBJECTIVE
  to evaluate the prevalence of CD in elderly population, recording the main clinical features of this group respect to young patients.
  
  
  METHODS
  We retrospectively analysed the prevalence of CD in an elderly population from 1970 to 2015. We divided patients into three age-groups (group A: 18-34 years; group B: 35-64 years; group C: ≥65 years) and compared them regarding baseline anthropometric and serological variables, clinical features at diagnosis, diagnostic mode, associated autoimmune diseases, and CD-related neoplastic complications.
  
  
  RESULTS
  We made 2812 CD diagnoses in adults: 2.5% of them were ≥65 years at diagnosis. When comparing the three groups, we found no differences in sex, haemoglobin, serum iron, albumin, and anti-tissue transglutaminase (anti-tTG) (p = NS) while as expected, we found higher values of cholesterol, glycaemia, and triglycerides in older patients (p < 0.0001). Elderly had a higher risk of being diagnosed with malabsorption symptoms compared to younger patients (OR 2.20, 95%CI 1.3-3.74). No difference in the risk of autoimmune CD-related diseases was seen among groups. Furthermore, we observed 16 neoplastic complications, 13 of them happened in the patients diagnosed with CD aged 35-64 years. The number of CD diagnoses increased over time, particularly in elderly.
  
  
  CONCLUSIONS
  CD diagnosis in elderly population is quite uncommon although not rare. Elderly CD patients have a higher risk of being diagnosed with malabsorption symptoms than younger patients but without increased risk of autoimmune and neoplastic complications.
authors.affiliation: a Department of Clinical Medicine and Surgery , University "Federico II" of Naples , Naples , Italy ;
authors.forename: Raffaella
authors.initials: R
authors.lastname: Tortora
authors.affiliation: a Department of Clinical Medicine and Surgery , University "Federico II" of Naples , Naples , Italy ;|b Department of Gastroenterology , University of Salerno , Salerno , Italy.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Zingone
authors.affiliation: a Department of Clinical Medicine and Surgery , University "Federico II" of Naples , Naples , Italy ;
authors.forename: Antonio
authors.initials: A
authors.lastname: Rispo
authors.affiliation: a Department of Clinical Medicine and Surgery , University "Federico II" of Naples , Naples , Italy ;|b Department of Gastroenterology , University of Salerno , Salerno , Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Bucci
authors.affiliation: a Department of Clinical Medicine and Surgery , University "Federico II" of Naples , Naples , Italy ;
authors.forename: Pietro
authors.initials: P
authors.lastname: Capone
authors.affiliation: a Department of Clinical Medicine and Surgery , University "Federico II" of Naples , Naples , Italy ;
authors.forename: Nicola
authors.initials: N
authors.lastname: Imperatore
authors.affiliation: a Department of Clinical Medicine and Surgery , University "Federico II" of Naples , Naples , Italy ;
authors.forename: Nicola
authors.initials: N
authors.lastname: Caporaso
authors.affiliation: a Department of Clinical Medicine and Surgery , University "Federico II" of Naples , Naples , Italy ;|b Department of Gastroenterology , University of Salerno , Salerno , Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: D'Agosto
authors.affiliation: a Department of Clinical Medicine and Surgery , University "Federico II" of Naples , Naples , Italy ;|b Department of Gastroenterology , University of Salerno , Salerno , Italy.
authors.forename: Carolina
authors.initials: C
authors.lastname: Ciacci
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood; D002446:Celiac Disease / Q000150:complications* / Q000453:epidemiology*; D002784:Cholesterol / Q000097:blood; D005260:Female; D019204:GTP-Binding Proteins / Q000276:immunology; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology; D007070:Immunoglobulin A / Q000097:blood; D007558:Italy; D016015:Logistic Models; D008286:Malabsorption Syndromes / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D011503:Transglutaminases / Q000276:immunology; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D014280:Triglycerides; D002784:Cholesterol; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins
keywords: Coeliac disease; diagnosis; elderly; epidemiology; prevalence