title: [Recent progress in genetic background of chronic obstructive pulmonary disease (COPD)].
abstract: A genetic contribution to develop chronic obstructive pulmonary disease(COPD) is estimated. However, candidate gene studies on COPD and related phenotypes have not been well replicated. Research on the genetic pathologic background of COPD using genome-wide association studies (GWASs) has progressed in recent years. The novel candidate genes including CHRNA3/5 (cholinergic nicotine receptor alpha 3/5), IREB2 (iron regulatory binding protein 2), HHIP (hedgehog-interacting protein), and FAM13A (family with sequence similarity 13, member A) are identified in multiple populations. However, their pathological roles remain poorly understood. The nicotine dependency, pulmonary development, and pulmonary/systemic inflammatory diathesis may be involved in genetic background of COPD.
authors.forename: Shinji
authors.initials: S
authors.lastname: Teramoto
mesh_terms: D002352:Carrier Proteins / Q000235:genetics; D018450:Disease Progression; D020690:GTPase-Activating Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D035942:Iron Regulatory Protein 2 / Q000235:genetics; D008562:Membrane Glycoproteins / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000235:genetics*; D011978:Receptors, Nicotinic / Q000235:genetics*; D012907:Smoking / Q000009:adverse effects / Q000235:genetics; D014029:Tobacco Use Disorder
chemical_list: D002352:Carrier Proteins; D020690:GTPase-Activating Proteins; D035942:Iron Regulatory Protein 2; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D011978:Receptors, Nicotinic; C447158:CHRNA5 protein, human; C570078:FAM13A protein, human; C117596:HHIP protein, human