title: Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress.
abstract: Baicalein (5,6,7-trihydroxy-2-phenyl-chromen-4-one) is a flavone, a type of flavonoid, originally isolated from the roots ofScutellaria baicalensis. This study evaluated the protective effects of baicalein against oxidative damage-mediated apoptosis induced by ultraviolet B (UVB) radiation in a human keratinocyte cell line (HaCaT). Baicalein absorbed light within the wavelength range of UVB. In addition, baicalein decreased the level of intracellular reactive oxygen species (ROS) in response to UVB radiation. Baicalein protected cells against UVB radiation-induced DNA breaks, 8-isoprostane generation and protein modification in HaCaT cells. Furthermore, baicalein suppressed the apoptotic cell death by UVB radiation. These findings suggest that baicalein protected HaCaT cells against UVB radiation-induced cell damage and apoptosis by absorbing UVB radiation and scavenging ROS.
authors.affiliation: School of Medicine, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Min Chang
authors.initials: MC
authors.lastname: Oh
authors.affiliation: School of Medicine, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Mei Jing
authors.initials: MJ
authors.lastname: Piao
authors.affiliation: School of Medicine, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Pattage Madushan Dilhara Jayatissa
authors.initials: PM
authors.lastname: Fernando
authors.affiliation: School of Medicine, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Xia
authors.initials: X
authors.lastname: Han
authors.affiliation: School of Medicine, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Susara Ruwan Kumara
authors.initials: SR
authors.lastname: Madduma Hewage
authors.affiliation: School of Medicine, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Jeong Eon
authors.initials: JE
authors.lastname: Park
authors.affiliation: College of Medicine, Soonchunhyang University, Cheonan 31140, Republic of Korea.
authors.forename: Mi Sung
authors.initials: MS
authors.lastname: Ko
authors.affiliation: Radiation Biotechnology Research Division, Korea Atomic Energy Research Institute, Jeongeup 56212, Republic of Korea.
authors.forename: Uhee
authors.initials: U
authors.lastname: Jung
authors.affiliation: Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, Daejeon 34057, Republic of Korea.|Department of Radiation Biotechnology and Applied Radioisotope, Korea University of Science and Technology, Daejeon 34113, Republic of Korea.
authors.forename: In Gyu
authors.initials: IG
authors.lastname: Kim
authors.affiliation: School of Medicine, Jeju National University, Jeju 63243, Republic of Korea.
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Hyun
keywords: Baicalein; HaCaT cells; Oxidative stress; Reactive oxygen species; Ultraviolet B