title: Hematopoiesis during development, aging, and disease.
abstract: Hematopoietic stem cells were once considered identical. However, in the mid-1990s, it became apparent that stem cells from a person's early developmental phases are superior to those from adults, and aged stem cells are defective compared with young stem cells. It has since become clear that polycomb group proteins are important regulators of stem cell functioning. Polycomb group proteins are chromatin-associated proteins involved in writing or reading epigenetic histone modifications. Polycomb group proteins are involved in normal blood cell formation, in cancer, and possibly in aging. In this review, we describe how the different phases of hematopoietic stem cells-birth, maintenance, functional decline, derailment, and death-are continuous processes that may be controlled by polycomb group proteins.
authors.affiliation: European Institute for the Biology of Ageing (ERIBA), Section on Ageing Biology and Stem Cells, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Johannes
authors.initials: J
authors.lastname: Jung
authors.affiliation: European Institute for the Biology of Ageing (ERIBA), Section on Ageing Biology and Stem Cells, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Sonja
authors.initials: S
authors.lastname: Buisman
authors.affiliation: European Institute for the Biology of Ageing (ERIBA), Section on Ageing Biology and Stem Cells, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands. Electronic address: g.de.haan@umcg.nl.
authors.forename: Gerald
authors.initials: G
authors.lastname: de Haan
mesh_terms: D000375:Aging; D000818:Animals; D004198:Disease Susceptibility; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D063146:Polycomb-Group Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D063146:Polycomb-Group Proteins