title: Prostate Cancer Detection Rate with Koelis Fusion Biopsies versus Cognitive Biopsies: A Comparative Study.
abstract: OBJECTIVE
  Targeted fusion biopsies have led to an improved prostate cancer (PCa) detection rate (CDR). Our aim was to assess if device-assisted fusion biopsies are superior to cognitive ones in terms of CDR. The association between multiparametric MRI parameters and PCa was also evaluated.
  
  
  METHODS
  We retrospectively enrolled 50 patients who underwent transrectal biopsy with elastic fusion (Koelis; group KB, n = 25) or cognitive approach (group CB, n = 25). Targeted biopsies were done on targets, while a variable number of random biopsies were performed depending on the clinical case.
  
  
  RESULTS
  The groups did not significantly differ in terms of age, prostate-specific antigen, prostate volume and previous biopsies. Mean number of random cores was significantly inferior in KB group (8.4 vs. 12.1) and mean number of targeted biopsies was significantly higher (3.6 vs. 2.6). CDR was higher in fusion biopsies (64 vs. 40%), with the gap becoming significant when considering CDR of MRI targets only (59 vs. 27%). The difference was marked for lesions ≤10 mm, where CDR was 52% in KB against 21% in CB group.
  
  
  CONCLUSIONS
  According to our study, elastic fusion biopsies performed with Koelis achieve an increased per-patient and per-lesion CDR as compared to cognitive biopsies, especially in the case of lesions ≤10 mm.
authors.affiliation: Department of Surgical Sciences, Urology, University of Turin, Turin, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Oderda
authors.forename: Riccardo
authors.initials: R
authors.lastname: Faletti
authors.forename: Giacomo
authors.initials: G
authors.lastname: Battisti
authors.forename: Ettore
authors.initials: E
authors.lastname: Dalmasso
authors.forename: Marco
authors.initials: M
authors.lastname: Falcone
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Marra
authors.forename: Anna
authors.initials: A
authors.lastname: Palazzetti
authors.forename: Andrea
authors.initials: A
authors.lastname: Zitella
authors.forename: Laura
authors.initials: L
authors.lastname: Bergamasco
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gandini
authors.forename: Paolo
authors.initials: P
authors.lastname: Gontero
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000379:methods; D006801:Humans; D061705:Image-Guided Biopsy; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies