title: Aggravation of spinal cord compromise following new osteoporotic vertebral compression fracture prevented by teriparatide in patients with surgical contraindications.
abstract: Patients with spinal cord deficits following new unstable osteoporotic compression fracture and surgical contraindications were considered to receive conservative treatment. Teriparatide was better than alendronate at improving bone mineral density and bone turnover parameters, as well as preventing aggravation of spinal cord compromise.
  
  
  
  This study compared the preventive effects of teriparatide and alendronate on aggravation of spinal cord compromise following new unstable osteoporotic vertebral compression fracture (OVCF) in patients with surgical contraindications.
  
  
  
  This was a 12-month, randomized, open-label study of teriparatide versus alendronate in 49 patients with new unstable OVCF and surgical contraindications. Neurological function was evaluated using modified Japanese Orthopedic Association (mJOA) score (11-point scale, the maximum score of 11 implies normalcy). Visual analog scale (VAS) scores, kyphotic angles, anterior-border heights and diameters of the spinal canal of the fractured vertebrae, any incident of new OVCFs (onset of OVCF during follow-up), spine bone mineral density (BMD), and serum markers of bone resorption and bone formation were also examined at baseline and 1, 3, 6, and 12 months after initiation of the medication regimen.
  
  
  
  At 12 months, mean mJOA score had improved in the teriparatide group and decreased in the alendronate group. Mean concentrations of bone formation and bone resorption biomarkers, mean spine BMD, and mean anterior-border height and spinal canal diameter of the fractured vertebrae were significantly greater in the teriparatide group than in the alendronate group. Mean VAS score, mean kyphotic angle of the fractured vertebrae, and incidence of new OVCFs were significantly smaller in the teriparatide group than in the alendronate group.
  
  
  
  In patients with neurological deficits following new unstable OVCF and with surgical contraindications, teriparatide was better than alendronate at improving the BMD and the bone turnover parameters, as well as preventing aggravation of spinal cord compromise.
authors.affiliation: Department of Orthopaedics, General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, China.|Department of Radiology, The Secondary Affiliated Hospital of Baotou Medical College, No. 22 Hudemulin Road, Qingshan District, Inner Mongolia, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Radiology and Tianjin Key Laboratory of Functional Imaging, General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, China.|School of Medical Imaging, Tianjin Medical University, No. 1 Guandong Road, Hexi District, Tianjin, China.
authors.forename: R
authors.initials: R
authors.lastname: Xue
authors.affiliation: Department of Operative Surgery, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin, China.
authors.forename: N
authors.initials: N
authors.lastname: Shi
authors.affiliation: Department of Orthopaedics, General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, China. xueyuanzyy@sina.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Department of Orthopaedics, General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zong
authors.affiliation: Department of Orthopaedics, General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, China.
authors.forename: W
authors.initials: W
authors.lastname: Lin
authors.affiliation: Department of Orthopaedics, General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, China.
authors.forename: B
authors.initials: B
authors.lastname: Pei
authors.affiliation: Department of Orthopaedics, General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, China.
authors.forename: C
authors.initials: C
authors.lastname: Sun
authors.affiliation: Department of Orthopaedics, General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, China.
authors.forename: R
authors.initials: R
authors.lastname: Fan
authors.affiliation: Department of Radiology and Tianjin Key Laboratory of Functional Imaging, General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000368:Aged; D019386:Alendronate / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D016723:Bone Remodeling; D000075202:Contraindications; D005260:Female; D050815:Fractures, Compression / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D013116:Spinal Cord / Q000503:physiopathology*; D016103:Spinal Fractures / Q000188:drug therapy*; D019379:Teriparatide / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers; D050071:Bone Density Conservation Agents; D019379:Teriparatide; D019386:Alendronate
keywords: Alendronate; Osteoporotic vertebral compression fracture; Spinal cord compromise; Teriparatide