title: Diagnostic value of elevated serum miRNA-143 levels in sepsis.
abstract: OBJECTIVE
  To evaluate serum micro RNA-143 (miR-143) levels in patients with sepsis or non-infectious systemic inflammatory response syndrome (SIRS), and investigate its possible diagnostic or prognostic value.
  
  
  METHODS
  Serum was obtained from patients with sepsis or SIRS and healthy control subjects. Relative miR-143 expression was determined using quantitative real time polymerase chain reaction. The diagnostic and prognostic value of serum miR-143 was evaluated.
  
  
  RESULTS
  Serum miR-143 levels were significantly higher in patients with sepsis (n = 103) than patients with SIRS (n = 95) and healthy controls (n = 40). There were significant positive correlations between serum miR-143 level and SOFA and APACHE II scores in patients with sepsis (r = 0.794 and r = 0.825, respectively). Serum miR-143 had a sensitivity of 78.6% and specificity of 91.6% for distinguishing between sepsis and SIRS. There was no association between serum miR-143 and 28-day survival in patients with sepsis.
  
  
  CONCLUSIONS
  Serum miR-143 is elevated in patients with sepsis, and may be a useful biomarker for distinguishing between sepsis and SIRS.
authors.affiliation: Department of Critical Care Medicine, Cangzhou Central Hospital, Cangzhou, Hebei Province, China drhanyu@163.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Critical Care Medicine, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.
authors.forename: Qing-Chun
authors.initials: QC
authors.lastname: Dai
authors.affiliation: Department of Critical Care Medicine, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Shen
authors.affiliation: Department of Critical Care Medicine, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D012372:ROC Curve; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis* / Q000235:genetics; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000175:diagnosis / Q000235:genetics; D055815:Young Adult
chemical_list: C542359:MIRN143 microRNA, human; D035683:MicroRNAs
keywords: MicroRNA-143; diagnosis; sepsis