title: Activity-dependent calcium signalling in oligodendrocyte generation.
abstract: Throughout postnatal life oligodendrocyte progenitor cells proliferate and differentiate into mature myelinating oligodendrocytes in the central nervous system. Neuronal activity is a major external signal controlling this process. Neurotransmitters, or other signalling molecules released in response to neuronal activity, evoke transient increases in intracellular calcium in oligodendrocyte progenitor cells. As calcium can mediate cellular processes, including the transcription of genes involved in oligodendrocyte progenitor cell division and maturation, a rise in intracellular calcium may be a key signal translating changes in neuronal activity into changes in oligodendrocyte progenitor cell behaviour. Here we review recent advances in our understanding of how neuronal activity can evoke calcium signalling in oligodendrocyte progenitor cells.
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania 7000, Australia.
authors.forename: Kimberley A
authors.initials: KA
authors.lastname: Pitman
authors.affiliation: Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania 7000, Australia. Electronic address: kaylene.young@utas.edu.au.
authors.forename: Kaylene M
authors.initials: KM
authors.lastname: Young
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D000066670:Cell Plasticity; D006801:Humans; D009103:Multiple Sclerosis / Q000473:pathology; D009836:Oligodendroglia / Q000166:cytology* / Q000473:pathology
keywords: Calcium; Myelin; Neurotransmitter; Oligodendrocyte