title: Association of rs6983267 Polymorphism and Thyroid Cancer Susceptibility: A Systematic Review and Meta-Analysis.
abstract: BACKGROUND Recent genome-wide association studies have identified rs6983267 polymorphism as a key locus in the 8q24 region associated with multisite cancers. However, the information on its association with thyroid cancer is inconclusive. The aim of this study was to determine whether this locus is a risk factor for susceptibility to thyroid cancer by conducting a meta-analysis. MATERIAL AND METHODS Relevant studies were identified by searching PubMed and Embase databases. The pooled odds ratio (OR) and corresponding 95% confidence interval (95% CI) were calculated. RESULTS A total of 4 studies including 2825 cases and 9684 controls were enrolled to this meta-analysis. The pooled data showed the G allele of the rs6983267 polymorphism is a risk factor for susceptibility to thyroid cancer (OR=1.08, 95%CI: 1.02-1.16, P=0.01). Significant associations were also found in homozygote comparison (GG vs. TT: OR=1.17, 95%CI: 1.03-1.33, P=0.02) and dominant model (GG+GT vs. TT: OR=1.13, 95%CI: 1.01-1.26, P=0.03). Borderline significant associations in similar directions were found in the recessive model (GG vs. GT+TT: OR=1.10, 95%CI: 0.99-1.22, P=0.07) and heterozygote comparison (GT vs. TT: OR=1.10, 95%CI: 0.99-1.24, P=0.09). CONCLUSIONS Our meta-analysis shows that the rs6983267 G>T polymorphism might be associated with higher risk of thyroid cancer. Further research with larger sample sizes and full investigation of confounding risk factors is needed to confirm or revise our conclusions.
authors.affiliation: Institute of Hepatobiliary Surgery, Hospital of Hepatobiliary Surgery, Chinese People's Liberation Army General Hospital, Beijing, China (mainland).
authors.forename: Jingdong
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of General Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China (mainland).
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Institute of Hepatobiliary Surgery, Hospital of Hepatobiliary Surgery, Chinese People's Liberation Army General Hospital, Beijing, China (mainland).
authors.forename: Jiahong
authors.initials: J
authors.lastname: Dong
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000235:genetics*