title: An Overview of Mouse Models of Nonalcoholic Steatohepatitis: From Past to Present.
abstract: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world. It is associated with obesity and type 2 diabetes and represents a spectrum of histological abnormalities ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), which can further progress to fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and liver failure. To gain insight into the pathogenesis and evaluate treatment options, mouse models of NAFLD/NASH are of utmost importance. There is a high phenotypical variety in the available mouse models, however, models that truly display the full spectrum of histopathological and metabolic features associated with human NASH are rare. In this review, we summarize the most important NAFLD/NASH mouse models that have been developed over the years and briefly highlight the pros and cons. Also, we illustrate the preclinical research in which these models have been used. © 2016 by John Wiley & Sons, Inc.
authors.affiliation: Department of Hepatology, University Hospitals KU Leuven, Leuven, Belgium.
authors.forename: Ans
authors.initials: A
authors.lastname: Jacobs
authors.affiliation: Department of Hepatology, University Hospitals KU Leuven, Leuven, Belgium.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Warda
authors.affiliation: Department of Hepatology, University Hospitals KU Leuven, Leuven, Belgium.|Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Jef
authors.initials: J
authors.lastname: Verbeek
authors.affiliation: Department of Hepatology, University Hospitals KU Leuven, Leuven, Belgium.|Metabolic Center, University Hospitals KU Leuven, Leuven, Belgium.
authors.forename: David
authors.initials: D
authors.lastname: Cassiman
authors.affiliation: Department of Laboratory Medicine, University Hospitals KU Leuven, Leuven, Belgium.
authors.forename: Pieter
authors.initials: P
authors.lastname: Spincemaille
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D065626:Non-alcoholic Fatty Liver Disease / Q000209:etiology*
keywords: NAFLD; NASH; mouse models; steatohepatitis; steatosis