title: Nano-TiO2/collagen-chitosan porous scaffold for wound repairing.
abstract: Collagen-Chitosan (COL-CS) porous scaffolds have been widely used as a dermal equivalent to induce fibroblasts infiltration and dermal regeneration. To improve the anti-bacterial properties, nano-TiO2 hydrosol was introduced into COL-CS scaffolds. TiO2/COL-CS porous scaffolds were fabricated through a freeze-drying process, and scanning electron microscopy (SEM) was employed to study the micro-structure of the scaffolds. Fourier transform infrared spectroscopy (FT-IR) was used to study the intermolecular interactions in the scaffolds. The swelling property, porosity, degradation, antibacterial behavior, red blood cell aggregation, and cytotoxicity of the composite were investigated. The results showed that the scaffold is good in permeability and it may provide a humid environment for wound repairing. The degradation in lysozyme solution for 4 weeks showed that porous scaffolds are good in stability, which may satisfy the wound coverage protection in the repairing period. An obvious inhibitory effect on Staphylococcus aureus of the porous scaffolds was found, and the red blood cells were easy to form clusters aggregation to stop bleeding. It was suggested that the TiO2/COL-CS composite scaffolds could be a promising candidate for wound repairing dressing.
authors.affiliation: College of Materials Science & Engineering, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Xialian
authors.initials: X
authors.lastname: Fan
authors.affiliation: College of Materials Science & Engineering, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Keke
authors.initials: K
authors.lastname: Chen
authors.affiliation: College of Materials Science & Engineering, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Xichan
authors.initials: X
authors.lastname: He
authors.affiliation: College of Materials Science & Engineering, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: College of Materials Science & Engineering, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Jinbao
authors.initials: J
authors.lastname: Huang
authors.affiliation: College of Materials Science & Engineering, Zhengzhou University, Zhengzhou 450001, China. Electronic address: keyongtangzzu@yahoo.com.
authors.forename: Keyong
authors.initials: K
authors.lastname: Tang
authors.affiliation: The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Yijin
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Materials Science & Engineering, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D048271:Chitosan / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry*; D004903:Erythrocyte Aggregation / Q000187:drug effects; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D013211:Staphylococcus aureus / Q000187:drug effects; D054457:Tissue Scaffolds / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; C009495:titanium dioxide; D003094:Collagen; D048271:Chitosan; D014025:Titanium
keywords: Chitosan; Collagen; Nano-TiO(2)