title: Impaired error processing in late-phase psychosis: Four-year stability and relationships with negative symptoms.
abstract: Error processing is impaired in psychosis, and numerous event-related potential studies have found reductions in the error-related negativity (ERN) and, more recently, the error positivity (Pe). The stability of reduced ERN/Pe in psychosis, however, is unknown. In a previous cross-sectional report, reduced ERN was associated with negative symptom severity and reduced Pe with a diagnosis of schizophrenia versus other psychosis. Here, we test the stability of impaired error processing over a four-year follow-up and relationships with subdimensions of negative symptoms. The ERN and Pe were recorded from individuals with psychotic disorders twice: 79 individuals were assessed 15years after first hospitalization, and 69 were assessed at 19years; 59 (26 with schizophrenia, 33 with other psychotic disorders) had data at both assessments. At 19years the Pe was blunted in schizophrenia. The ERN and Pe exhibited temporal stability over the four years (r=0.59 and 0.60, respectively). Reduced ERN and Pe correlated with the negative symptom subdimensions of inexpressivity and avolition, respectively, and not with psychotic or disorganized symptoms. Moreover, 15-year ERN predicted an increase in inexpressivity by year 19. No evidence was found for the reverse: negative symptoms did not predict change in ERN/Pe. Similar to non-clinical samples, the ERN and Pe show impressive four-year stability in late-phase psychosis. The ERN and Pe are promising neural measures for capturing individual differences in psychotic disorders, particularly with regard to negative symptomatology. They may prove to be useful clinically for forecasting illness course and as treatment targets.
authors.affiliation: Department of Psychological Sciences, Purdue University, West Lafayette, IN, United States. Electronic address: foti@purdue.edu.
authors.forename: Dan
authors.initials: D
authors.lastname: Foti
authors.affiliation: Department of Psychiatry, Stony Brook University, Stony Brook, NY, United States.
authors.forename: Greg
authors.initials: G
authors.lastname: Perlman
authors.affiliation: Department of Psychology, Stony Brook University, Stony Brook, NY, United States.
authors.forename: Greg
authors.initials: G
authors.lastname: Hajcak
authors.affiliation: Department of Psychology, Stony Brook University, Stony Brook, NY, United States.
authors.forename: Aprajita
authors.initials: A
authors.lastname: Mohanty
authors.affiliation: Department of Psychology, Stony Brook University, Stony Brook, NY, United States.
authors.forename: Felicia
authors.initials: F
authors.lastname: Jackson
authors.affiliation: Department of Psychiatry, Stony Brook University, Stony Brook, NY, United States.
authors.forename: Roman
authors.initials: R
authors.lastname: Kotov
mesh_terms: D001921:Brain / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D018450:Disease Progression; D004569:Electroencephalography; D005071:Evoked Potentials; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology* / Q000628:therapy; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D012565:Schizophrenic Psychology; D013997:Time Factors
keywords: EEG; ERP; Error positivity; Error-related negativity; Schizophrenia