title: Externally controlled drug release using a gold nanorod contained composite membrane.
abstract: Versatile drug delivery devices using nanoporous membranes consisting of gold nanorods and dendrimers have been demonstrated to provide light-triggered on-demand pulsatile release from a reservoir containing highly enriched therapeutics for a real patient's needs. The drug release rate is directly correlated with the temperature increase and irradiated energy of a near-IR laser in both static and fluidic devices. This biocompatible platform for on-demand control was further confirmed by in vitro experiments. Interestingly, different responses to stimuli were obtained from each drug in the absence and presence of NIR light, indicating the versatile potential of our on-demand drug delivery system in less-invasive therapies requiring multi-drug delivery strategies. The enhanced delivery system will improve therapeutic efficacy and reduce side effects through regulation of plasma drug profiles.
authors.affiliation: Department of Chemistry, Sahmyook University, Seoul, 01795, Korea. mpark@syu.ac.kr and Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, 44919, Korea. jhryu@unist.ac.kr.
authors.forename: Kibeom
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Sahmyook University, Seoul, 01795, Korea. mpark@syu.ac.kr.
authors.forename: Min-Chul
authors.initials: MC
authors.lastname: Jo
authors.affiliation: Department of Chemistry, Sahmyook University, Seoul, 01795, Korea. mpark@syu.ac.kr.
authors.forename: Sundo
authors.initials: S
authors.lastname: Jeong
authors.affiliation: Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, 44919, Korea. jhryu@unist.ac.kr.
authors.forename: L
authors.initials: L
authors.lastname: Palanikumar
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
authors.affiliation: Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, 44919, Korea. jhryu@unist.ac.kr.
authors.forename: Ja-Hyoung
authors.initials: JH
authors.lastname: Ryu
authors.affiliation: Department of Chemistry, Sahmyook University, Seoul, 01795, Korea. mpark@syu.ac.kr.
authors.forename: Myoung-Hwan
authors.initials: MH
authors.lastname: Park