title: Retinal thermal damage threshold dependence on exposure duration for the transitional near-infrared laser radiation at 1319 nm.
abstract: The retinal damage effects induced by transitional near-infrared (NIR) lasers have been investigated for years. However, the damage threshold dependence on exposure duration has not been revealed. In this paper, the in-vivo retinal damage ED50 thresholds were determined in chinchilla grey rabbits for 1319 nm laser radiation for exposure durations from 0.1 s to 10 s. The incident corneal irradiance diameter was fixed at 5 mm. The ED50 thresholds given in terms of the total intraocular energy (TIE) for exposure durations of 0.1, 1 and 10 s were 1.36, 6.33 and 28.6 J respectively. The ED50 thresholds were correlated by a power law equation, ED50 = 6.31t (0.66) [J] where t is time [s], with correlation coefficient R = 0.9999. There exists a sufficient safety margin (factor of 28~60) between the human ED50 thresholds derived from the rabbit and the maximum permissible exposure (MPE) values in the current laser safety standards.
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China; These authors contributed equally to this work.
authors.forename: Jiarui
authors.initials: J
authors.lastname: Wang
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China; These authors contributed equally to this work; jiaoluguang001@163.com.
authors.forename: Luguang
authors.initials: L
authors.lastname: Jiao
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Jing
authors.affiliation: Department of Dermatology, First Affiliated Hospital of PLA General Hospital, Beijing 10048, China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Chen
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Hu
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Zaifu
authors.initials: Z
authors.lastname: Yang
keywords: (140.3360) Laser safety and eye protection; (350.5340) Photothermal effects; (350.6830) Thermal lensing