title: Comparison between resting state fMRI networks and responsive cortical stimulations in glioma patients.
abstract: To validate the functional relevance of resting state networks (RSNs) by means of a comparison of resting state connectivity (RSC) between language regions elicited by direct cortical stimulation versus RSC between random regions; and to evaluate the accuracy of resting state fMRI in surgical planning by assessing the overlap between RSNs and intraoperative functional mapping results.
  
  
  
  Sensorimotor and language eloquent sites were identified by direct electrical cortical stimulation in 98 patients with a diffuse low-grade glioma. A seed to voxel analysis with inter-language stimulation point connectivity versus inter-random ROIs connectivity was performed (19 patients). An independant component analysis (ICA) was also applied to rsfMRI data. Language and sensorimotor components were selected over 20 independent components and compared to the corresponding stimulation points and resected cortex masks (31 and 90 patients, respectively).
  
  
  
  Mean connectivity value between language seeds was significantly higher than the one between random seeds (0.68 ± 0.39 and 0.12 ± 0.21 respectively, P < 10-10). 96 ± 11% of sensorimotor stimulation points were located within 10 mm from sensorimotor ICA maps versus 92 ± 21% for language. 3.1 and 15% of resected cortex overlapped sensorimotor and language networks, respectively. Mean sensorimotor stimulation points and resected cortex z-scores were 2.0 ± 1.2 and -0.050 ± 0.60, respectively (P < 10-10). Mean language stimulation points and resected cortex z-scores were 1.6 ± 1.9 and 0.68 ± 0.91, respectively, P < 0.005.
  
  
  
  The significantly higher RSC between language seeds than between random seeds validated the functional relevance of RSC. ICA partly succeeded to distinguish eloquent versus surgically removable areas and may be possibly used as a complementary tool to intraoperative mapping. Hum Brain Mapp 37:3721-3732, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Neurosurgery, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.|Unité I2FH, Institut d'Imagerie Fonctionnelle Humaine, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.|Team "Plasticity of Central Nervous System, Stem Cells and Glial Tumors", INSERM U1051, Institute of Neurosciences of Montpellier, Montpellier, France.|Department of Neuroradiology, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Cochereau
authors.affiliation: Unité I2FH, Institut d'Imagerie Fonctionnelle Humaine, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.|Department of Neuroradiology, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.|Institut de Génomique Fonctionnelle, Unité UMR 5203 - INSERM U661 - Université Montpellier II - Université Montpellier I, France.|Laboratoire Charles Coulomb, Unité CNRS UMR 5221 - Université Montpellier II, Montpellier, France.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Deverdun
authors.affiliation: Department of Neurosurgery, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.|Team "Plasticity of Central Nervous System, Stem Cells and Glial Tumors", INSERM U1051, Institute of Neurosciences of Montpellier, Montpellier, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Herbet
authors.affiliation: Unité I2FH, Institut d'Imagerie Fonctionnelle Humaine, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.|Department of Neuroradiology, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.
authors.forename: Céline
authors.identifier: 0000-0001-5754-3178
authors.initials: C
authors.lastname: Charroud
authors.affiliation: Unité I2FH, Institut d'Imagerie Fonctionnelle Humaine, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.|University of Montpellier 2, LIRMM laboratory, DEMAR Team, CNRS, INRIA, Montpellier, 34095, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Boyer
authors.affiliation: Department of Neurosurgery, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.|Team "Plasticity of Central Nervous System, Stem Cells and Glial Tumors", INSERM U1051, Institute of Neurosciences of Montpellier, Montpellier, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Moritz-Gasser
authors.affiliation: Unité I2FH, Institut d'Imagerie Fonctionnelle Humaine, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.|Department of Neuroradiology, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.|Laboratoire Charles Coulomb, Unité CNRS UMR 5221 - Université Montpellier II, Montpellier, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Le Bars
authors.affiliation: Institut de Génomique Fonctionnelle, Unité UMR 5203 - INSERM U661 - Université Montpellier II - Université Montpellier I, France.|Laboratoire Charles Coulomb, Unité CNRS UMR 5221 - Université Montpellier II, Montpellier, France.
authors.forename: François
authors.initials: F
authors.lastname: Molino
authors.affiliation: Unité I2FH, Institut d'Imagerie Fonctionnelle Humaine, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.|Team "Plasticity of Central Nervous System, Stem Cells and Glial Tumors", INSERM U1051, Institute of Neurosciences of Montpellier, Montpellier, France.|Department of Neuroradiology, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Bonafé
authors.affiliation: Unité I2FH, Institut d'Imagerie Fonctionnelle Humaine, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.|Team "Plasticity of Central Nervous System, Stem Cells and Glial Tumors", INSERM U1051, Institute of Neurosciences of Montpellier, Montpellier, France.|Department of Neuroradiology, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.|Laboratoire Charles Coulomb, Unité CNRS UMR 5221 - Université Montpellier II, Montpellier, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Menjot de Champfleur
authors.affiliation: Department of Neurosurgery, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.|Team "Plasticity of Central Nervous System, Stem Cells and Glial Tumors", INSERM U1051, Institute of Neurosciences of Montpellier, Montpellier, France.
authors.forename: Hugues
authors.initials: H
authors.lastname: Duffau
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D004558:Electric Stimulation; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D021621:Imaging, Three-Dimensional; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D011300:Preoperative Care; D012146:Rest
keywords: brain mapping; functional magnetic resonance imaging; glioma; language; neurosurgery; resting-state fMRI; sensorimotor cortex