title: Outcomes of lung cancers manifesting as nonsolid nodules.
abstract: This is a comprehensive review and re-analysis of available literature to assess the outcome of lung cancer presenting as nonsolid nodules (NSNs), a more indolent form of cancer. PubMed and EMBASE were searched for articles reporting on CT-detected lung cancers manifesting as NSNs published in English on or before July 17, 2015. Only studies including clinicopathologic data, lung cancer-specific survival, or overall survival were included. Data extraction was performed by three independent reviewers using prespecified criteria. Twenty-four articles from 5 countries met criteria and they included 704 subjects with 712 lung cancers manifesting as NSNs. Each article reported from 2 to 100 lung cancer cases with a median follow up of 18-51 months. All NSNs were Stage I adenocarcinoma without pathologic nodal involvement upon resection, except for one case in which the NSN progressed to become part-solid nodule after 6 years of follow-up. The five-year lung cancer-specific survival rate was 100%. These findings suggest an indolent course for lung cancers manifesting as NSNs.
authors.affiliation: Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: Rowena.yip@mountsinai.org.
authors.forename: Rowena
authors.initials: R
authors.lastname: Yip
authors.affiliation: Departments of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
authors.forename: Andrea
authors.initials: A
authors.lastname: Wolf
authors.affiliation: Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Tam
authors.affiliation: Departments of Population Health Science and Policy and Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Taioli
authors.affiliation: Department of Statistics, Stanford University, Stanford, CA, United States.
authors.forename: Ingram
authors.initials: I
authors.lastname: Olkin
authors.affiliation: Departments of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
authors.forename: Raja M
authors.initials: RM
authors.lastname: Flores
authors.affiliation: Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
authors.forename: David F
authors.initials: DF
authors.lastname: Yankelevitz
authors.affiliation: Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
authors.forename: Claudia I
authors.initials: CI
authors.lastname: Henschke
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008297:Male; D008403:Mass Screening; D055613:Multiple Pulmonary Nodules / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D017063:Outcome Assessment, Health Care / Q000379:methods*; D015996:Survival Rate; D014057:Tomography, X-Ray Computed
keywords: Lung neoplasm; Screening; Surgery; Surveillance; Survival