title: [Effects of rapamycin on amyloid β-protein induced impairments of working memory and synaptic plasticity in rats].
abstract: OBJECTIVE
  The present study investigated the effects of rapamycin on Aβ1-42-induced deficits in working memory and synaptic plasticity.
  
  
  METHODS
  After bilateral hippocampal injection of Aβ1-42 and rapamycinin rats, spontaneous alternation in Y-maze and in vivo hippocampal long-term potentiation (LTP) of rats were recorded. All data were analized by two-way repeated measures analysis of variance (ANOVA).
  
  
  RESULTS
  (Hippocampal injection of Aβ1-42 alone impaired working memory of rats; (2) Rapamycin did not affect working memory of rats, but alleviated Aβ1-42-induced working memory deficits, compared with Aβ1-42 alone group; (Aβ1-42 remarkably suppressed in vivo hippocampal LTP of fEPSPs in the CA1 region; (4) Pretreatment with rapamycin prevented Aβ1-42-induced suppression of LTP.
  
  
  CONCLUSIONS
  These data indicates that rapamycin could protect against Aβ1-42-induced impairments in working memory and synaptic plasticity in rats.
authors.forename: Ming
authors.initials: M
authors.lastname: Hao
authors.forename: Jia-qing
authors.initials: JQ
authors.lastname: Tong
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Mei-na
authors.initials: MN
authors.lastname: Wu
authors.forename: Jin-shun
authors.initials: JS
authors.lastname: Qi
mesh_terms: D016229:Amyloid beta-Peptides / Q000009:adverse effects*; D000818:Animals; D006624:Hippocampus / Q000187:drug effects*; D017774:Long-Term Potentiation; D018782:Maze Learning; D008570:Memory, Short-Term / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects*; D010446:Peptide Fragments / Q000009:adverse effects*; D051381:Rats; D020123:Sirolimus / Q000494:pharmacology*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D020123:Sirolimus