title: Potential diagnostic and prognostic biomarkers for cholangiocarcinoma in serum and bile.
abstract: Cholangiocarcinoma (CCA) is a devastating malignancy that is difficult to treat because of its insensitivity to conventional therapies and the inability to detect early tumor formation. Novel molecular techniques have enabled the use of serum and bile markers for CCA diagnosis and prognosis. Herein, we summarize the principal characteristics of serum and bile markers of CCA. Biomarkers such as interleukin-6, matrix metalloproteinases, serotonin (5-hydroxytryptamine) and bile acids have shown promise for improving CCA diagnosis. Several markers such as CYFRA 21-1, MK-1 and C-reactive protein were recently shown to be effective for CCA prognosis.
authors.affiliation: Department of Hepatobiliary Surgery, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang 322100, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary Surgery, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang 322100, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.affiliation: Graduate Institute of Basic Medical Science, College of Medicine, China Medical University, Taichung 40402, Taiwan.|Department of Computer Science & Information Engineering, Asia University, Taichung 41354, Taiwan.
authors.forename: Hao-Teng
authors.initials: HT
authors.lastname: Chang
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D001647:Bile Acids and Salts / Q000032:analysis*; D001650:Bile Duct Neoplasms / Q000175:diagnosis*; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000473:pathology; D000071858:Epithelial Cell Adhesion Molecule / Q000097:blood; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D053539:Keratin-19 / Q000097:blood; D009077:Mucins / Q000097:blood; D011379:Prognosis; D012701:Serotonin / Q000032:analysis
chemical_list: D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D001647:Bile Acids and Salts; D014408:Biomarkers, Tumor; C499379:EPCAM protein, human; D000071858:Epithelial Cell Adhesion Molecule; D015850:Interleukin-6; D053539:Keratin-19; D009077:Mucins; C102012:antigen CYFRA21.1; C578959:carbohydrate antigen 199, human; D012701:Serotonin; D002097:C-Reactive Protein
keywords: bile; biomarker; cholangiocarcinoma; serum