title: Bilirubin Binding Capacity in the Preterm Neonate.
abstract: Total serum/plasma bilirubin (TB), the biochemical measure currently used to evaluate and manage hyperbilirubinemia, is not a useful predictor of bilirubin-induced neurotoxicity in premature infants. Altered bilirubin-albumin binding in premature infants limits the usefulness of TB in premature infants. In this article, bilirubin-albumin binding, a modifying factor for bilirubin-induced neurotoxicity, in premature infants is reviewed.
authors.affiliation: Division of Neonatology, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Box 651, 601 Elmwood Avenue, Rochester, NY 14642, USA. Electronic address: Sanjiv_Amin@urmc.rochester.edu.
authors.forename: Sanjiv B
authors.initials: SB
authors.lastname: Amin
mesh_terms: D001663:Bilirubin / Q000378:metabolism*; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000150:complications / Q000378:metabolism*; D007231:Infant, Newborn; D007234:Infant, Premature; D007647:Kernicterus / Q000209:etiology / Q000378:metabolism; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D012709:Serum Albumin; D001663:Bilirubin
keywords: Bilirubin-induced neurotoxicity; Bilirubin:albumin molar ratio; Bilirubin–albumin binding affinity; Total serum bilirubin; Unbound bilirubin