title: [Clinical and radiologic characteristics of craniomaxillofacial primary tumor induced osteomalacia: a retrospective analysis].
abstract: OBJECTIVE
  To investigate the diagnosis strategy, radiology and clinical pathology feature of craniomaxillofacial primary tumor induced osteomalacia.
  
  
  METHODS
  Twelve cases of craniomaxillofacial primary tumor induced osteomalacia were reviewed, including 5 male and 7 female with a age range from 16 to 69 years. The clinical characteristics, radiology examinations and pathological features were analyzed.
  
  
  RESULTS
  The craniomaxillofacial primary tumor induced osteomalacia occurred in different ages, with 2 to 30 years of medical history. Seven of the twelve cases were octreotide scintigraphy positive, nine of the twelve cases invaded bone, exhibiting destruction of the adjacent cortex, ten of the twelve showed gingival lesions of local thickening or epulis. The tumor arises from mesenchymal tissue, infiltrating local gingiva and bone trabecular with spindle like fibroblasts and dental epithelial rests.
  
  
  CONCLUSIONS
  The concealed nature of the tumor induced osteomalacia requires multiple methods to locate the primary tumor and the tumors located in craniomaxillofacial region have unique clinical and pathological features.
authors.affiliation: Department of Stomatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Stomatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Stomatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: H D
authors.initials: HD
authors.lastname: Xue
authors.affiliation: Department of Stomatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Stomatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: D R
authors.initials: DR
authors.lastname: Zhong
authors.affiliation: Department of Stomatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005147:Facial Bones / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008441:Maxillary Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D009372:Neoplasms, Connective Tissue / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D010018:Osteomalacia; D010257:Paraneoplastic Syndromes; D011859:Radiography; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012888:Skull Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D055815:Young Adult