title: Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT2C receptor agonists.
abstract: The 5-HT2C receptor agonist lorcaserin (Belviq®) has been approved by the FDA for the treatment of obesity. Impulsivity is a contributory feature of some eating disorders.
  
  
  
  Experiments investigated the effect of lorcaserin and the highly selective 5-HT2C agonist CP-809101 on measures of impulsivity and on reinstatement of food-seeking behaviour, a model of dietary relapse. The effect of both drugs on 22-h deprivation-induced feeding was also examined, as was the effect of prefeeding in each impulsivity test.
  
  
  
  Lorcaserin (0.3-0.6 mg/kg SC) and CP-809101 (0.6-1 mg/kg SC) reduced premature responding in rats trained on the 5-CSRTT and improved accuracy in a Go-NoGo task by reducing false alarms. At equivalent doses, both drugs also reduced reinstatement for food-seeking behaviour. Neither drug altered impulsive choice measured in a delay-discounting task. Lorcaserin (1-3 mg/kg SC) and CP-809101 (3-6 mg/kg SC) reduced deprivation-induced feeding but only at higher doses.
  
  
  
  These results suggest that in addition to previously reported effects on satiety and reward, altered impulse control may represent a contributory factor to the anti-obesity property of 5-HT2C receptor agonists. Lorcaserin may promote weight loss by improving adherence to dietary regimens in individuals otherwise prone to relapse and may be beneficial in cases where obesity is associated with eating disorders tied to impulsive traits, such as binge eating disorder.
authors.affiliation: InterVivo Solutions Inc., 120 Carlton Street, Toronto, ON, M5A 4K2, Canada. guyh@intervivo.com.|Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 4K2, Canada. guyh@intervivo.com.
authors.forename: Guy A
authors.initials: GA
authors.lastname: Higgins
authors.affiliation: InterVivo Solutions Inc., 120 Carlton Street, Toronto, ON, M5A 4K2, Canada.
authors.forename: Leo B
authors.initials: LB
authors.lastname: Silenieks
authors.affiliation: Department of Psychology, Wake Forest University, Winston-Salem, NC, 27109, USA.
authors.forename: Everett B
authors.initials: EB
authors.lastname: Altherr
authors.affiliation: Vivocore, 120 Carlton Street, Toronto, ON, M5A 4K2, Canada.
authors.forename: Cam
authors.initials: C
authors.lastname: MacMillan
authors.affiliation: Department of Psychiatry, University of Toronto, Toronto, ON, M5T 1R8, Canada.|Department of Psychology, University of Toronto, Toronto, ON, M5S 3G3, Canada.|Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Fletcher
authors.affiliation: Department of Psychology, Wake Forest University, Winston-Salem, NC, 27109, USA.
authors.forename: Wayne E
authors.initials: WE
authors.lastname: Pratt
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D002755:Choice Behavior / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D007175:Impulsive Behavior / Q000187:drug effects*; D008297:Male; D009765:Obesity / Q000188:drug therapy; D010879:Piperazines / Q000493:pharmacokinetics*; D011719:Pyrazines / Q000493:pharmacokinetics*; D051381:Rats; D012201:Reward; D058826:Serotonin 5-HT2 Receptor Agonists / Q000494:pharmacology*
chemical_list: D001552:Benzazepines; C518685:CP-809,101; D010879:Piperazines; D011719:Pyrazines; D058826:Serotonin 5-HT2 Receptor Agonists; C506658:lorcaserin
keywords: 5-HT2C receptor; Binge eating disorder; CP-809101; Food reinstatement; Impulsivity; Lorcaserin; Prefeeding; Rat