title: Organ-to-Cell-Scale Health Assessment Using Geographical Information System Approaches with Multibeam Scanning Electron Microscopy.
abstract: This study combines novel multibeam electron microscopy with a geographical information system approach to create a first, seamless, navigable anatomic map of the human hip and its cellular inhabitants. Using spatial information acquired by localizing relevant map landmarks (e.g. cells, blood vessels), network modeling will enable disease epidemiology studies in populations of cells inhabiting tissues and organs.
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales, Samuels 509, UNSW Sydney, NSW, 2052, Australia.
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Knothe Tate
authors.affiliation: Carl Zeiss Microscopy GmbH, Oberkochen, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Zeidler
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales, Samuels 509, UNSW Sydney, NSW, 2052, Australia.
authors.forename: André F
authors.initials: AF
authors.lastname: Pereira
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales, Samuels 509, UNSW Sydney, NSW, 2052, Australia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hageman
authors.affiliation: Carl Zeiss Microscopy GmbH, Oberkochen, Germany.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Garbowski
authors.affiliation: Ministry of Science and Technology, Government of India - Department of Science and Technology, New Delhi, 110016, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Mishra
authors.affiliation: School of Civil and Environmental Engineering, University of New South Wales, UNSW Sydney, NSW, 2052, Australia.
authors.forename: Lauren
authors.initials: L
authors.lastname: Gardner
authors.affiliation: Orthopaedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
authors.forename: Ulf R
authors.initials: UR
authors.lastname: Knothe
mesh_terms: D005260:Female; D005270:Femur Head / Q000648:ultrastructure*; D040362:Geographic Information Systems; D006801:Humans; D008297:Male; D064347:Microscopy, Electrochemical, Scanning / Q000295:instrumentation* / Q000379:methods*
keywords: cell physiology; diagnostics; geographical information system; health assessment; organ physiology; scanning electron microscopy; seamless multiscale imaging