title: Perspectives on the use of biomaterials to store platelets for transfusion.
abstract: Platelets are routinely stored enabling transfusions for a range of conditions. While the current platelet storage bags, composed of either polyvinylchloride or polyolefin, are well-established, the storage of platelets in these bags beyond 7 days reduces platelet viability below clinically usable levels. New materials and coatings that promote platelet respiration while not supporting platelet adhesion or activation have started to emerge, with the potential to enable platelet storage beyond 7 days. This review focuses on the literature describing currently used biomaterials for platelet storage and emerging materials that are showing promise for improving platelet storage.
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales 2052, Australia.
authors.forename: Brooke L
authors.initials: BL
authors.lastname: Farrugia
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales 2052, Australia.
authors.forename: Keerthana
authors.initials: K
authors.lastname: Chandrasekar
authors.affiliation: Research and Development, Australian Red Cross Blood Service, 17 O'Riordan Street, Alexandria, New South Wales 2015, Australia.
authors.forename: Lacey
authors.initials: L
authors.lastname: Johnson
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales 2052, Australia.
authors.forename: John M
authors.initials: JM
authors.lastname: Whitelock
authors.affiliation: Research and Development, Australian Red Cross Blood Service, 17 O'Riordan Street, Alexandria, New South Wales 2015, Australia.
authors.forename: Denese C
authors.initials: DC
authors.lastname: Marks
authors.affiliation: Research and Development, Australian Red Cross Blood Service, 17 O'Riordan Street, Alexandria, New South Wales 2015, Australia.
authors.forename: David O
authors.initials: DO
authors.lastname: Irving
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales 2052, Australia.
authors.forename: Megan S
authors.initials: MS
authors.lastname: Lord
mesh_terms: D001792:Blood Platelets / Q000502:physiology*; D002470:Cell Survival; D020099:Coated Materials, Biocompatible; D006801:Humans; D017713:Platelet Transfusion; D011309:Preservation, Biological / Q000379:methods*
chemical_list: D020099:Coated Materials, Biocompatible