title: [SOME CLINICAL AND IMMUNOLOGICAL ASPECTS OF PRETERM BIRTH].
abstract: Aim - to make a comparative assessment of the cytokines level in women with preterm labor with chronic infection and without it in order to determine the risk of implementation of intrauterine infection in their preterm infants. There was prospective investigation of 141 pregnant and their 141 premature infants with different gestation terms. There was identify cytokines levels in mother's blood with immune enzyme analysis method due implementation of intrauterine infection in compare with control group. It wasinterconnection ofinfection pathology withgestation terms, it lead to preterm labor. Prematurity which cause by mothers chronic infection, lead to heavier, extended period of bacterial infection in premature infants. It was increasing of cytokines levels IL-1β, IL-6, and TNF-α of mother's blood during implementation of intrauterine infection in premature infants. Multiparous pregnant, adverse outcomes of previous pregnancies in anamnesis, high frequency carrier of bacterial infection were risk factors for preterm labor among explored pregnant women. To study cytokine profile among the explored pregnant women from main group showed a pattern in increasing of level IL-1β, IL- 6 and TNF-α serum during pregnancy , indicating the course of pregnancy and can be used as a nonspecific marker for early diagnosis of preterm birth and implementing infection in premature . The level of IL-2 did not have a diagnostic value.
authors.affiliation: Karaganda State Medical University, department of childhood diseases №3, Kazakhstan.
authors.forename: K
authors.initials: K
authors.lastname: Zhumakanova
authors.affiliation: Karaganda State Medical University, department of childhood diseases №3, Kazakhstan.
authors.forename: B
authors.initials: B
authors.lastname: Abeuova
authors.affiliation: Karaganda State Medical University, department of childhood diseases №3, Kazakhstan.
authors.forename: A
authors.initials: A
authors.lastname: Kuzgibekova
authors.affiliation: Karaganda State Medical University, department of childhood diseases №3, Kazakhstan.
authors.forename: K
authors.initials: K
authors.lastname: Kenzhebayeva
authors.affiliation: Karaganda State Medical University, department of childhood diseases №3, Kazakhstan.
authors.forename: G
authors.initials: G
authors.lastname: Eremicheva
mesh_terms: D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D053583:Interleukin-1beta / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D047928:Premature Birth / Q000097:blood* / Q000276:immunology; D011446:Prospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015415:Biomarkers; D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha