title: Neoadjuvant intratumoral immuno-gene therapy for non-small cell lung cancer.
abstract: Non-small Cell Lung Cancer (NSCLC) remains a deadly disease despite aggressive treatment protocols which incorporate chemotherapy, radiation and surgery. These traditional approaches have reached a plateau in therapeutic benefit. There is emerging evidence suggesting that immunotherapy can serve as an alternative treatment modality for NSCLC. Our group has nearly two decades of experience involving immuno-gene therapy with Ad.hIFN-α and Ad.hIFN-β in human mesothelioma trials, and has observed both safety and efficacy in treatment of Thoracic malignancies. We have expanded the scope of our work and have obtained encouraging pre-clinical evidence suggesting a role for immunotherapy as a surgical adjuvant for NSCLC cancers. By combining immunotherapy with surgery, synergistic results have been observed. Based on these observations, we have prepared a Phase I Clinical Trial that pairs Ad.hIFN-α with surgery for patients with resectable NSCLC. Patient enrollment is likely to begin in the Summer of 2016. We hope that this trial will serve as a platform for future trials aimed at pairing immunotherapy with surgery for patients diagnosed with NSCLC.
authors.affiliation: Division of Thoracic Surgery, Thoracic Surgery Research Laboratory, University of Pennsylvania Perelman School of Medicine, Philadelphia PA 19104, USA.
authors.forename: Jarrod D
authors.initials: JD
authors.lastname: Predina
authors.affiliation: Division of Thoracic Surgery, Thoracic Surgery Research Laboratory, University of Pennsylvania Perelman School of Medicine, Philadelphia PA 19104, USA.
authors.forename: Jane
authors.initials: J
authors.lastname: Keating
authors.affiliation: Division of Thoracic Surgery, Thoracic Surgery Research Laboratory, University of Pennsylvania Perelman School of Medicine, Philadelphia PA 19104, USA.
authors.forename: Ollin
authors.initials: O
authors.lastname: Venegas
authors.affiliation: Division of Thoracic Surgery, Thoracic Surgery Research Laboratory, University of Pennsylvania Perelman School of Medicine, Philadelphia PA 19104, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Nims
authors.affiliation: Division of Thoracic Surgery, Thoracic Surgery Research Laboratory, University of Pennsylvania Perelman School of Medicine, Philadelphia PA 19104, USA.
authors.forename: Sunil
authors.initials: S
authors.lastname: Singhal
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D019496:Cancer Vaccines / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D002986:Clinical Trials as Topic; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000627:therapeutic use; D005910:Glioma / Q000628:therapy; D006801:Humans; D016898:Interferon-alpha / Q000235:genetics*; D016899:Interferon-beta / Q000235:genetics; D008175:Lung Neoplasms / Q000276:immunology / Q000628:therapy*; D008654:Mesothelioma / Q000628:therapy; D020360:Neoadjuvant Therapy / Q000379:methods*; D009367:Neoplasm Staging; D010997:Pleural Neoplasms / Q000628:therapy; D011013:Pneumonectomy; D001749:Urinary Bladder Neoplasms / Q000628:therapy
chemical_list: D019496:Cancer Vaccines; D016898:Interferon-alpha; D016899:Interferon-beta