title: How hibernation and hypothermia help to improve anticoagulant control.
abstract: Winter is coming. Some animals successfully cope with the hostility of this season by hibernating. But how do hibernators survive the procoagulant state of months of immobility at very low body temperatures, with strongly decreased blood flow and increased blood viscosity? Changing the coagulation system seems crucial for preventing thromboembolic complications.
authors.affiliation: Department of Clinical Pharmacy and Pharmacology; University Medical Center Groningen ; University of Groningen ; Groningen, The Netherlands.
authors.forename: Edwin L
authors.initials: EL
authors.lastname: de Vrij
authors.affiliation: Department of Clinical Pharmacy and Pharmacology; University Medical Center Groningen ; University of Groningen ; Groningen, The Netherlands.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Henning
keywords: coagulation; hemostasis; hibernation; hypothermia; margination; metabolism; platelet; temperature; thrombocy-topenia; thrombosis