title: Divergent Synthesis of Quinazolin-4(3H)-ones and Tryptanthrins Enabled by a tert-Butyl Hydroperoxide/K3PO4-Promoted Oxidative Cyclization of Isatins at Room Temperature.
abstract: A synergetic tert-butyl hydroperoxide/K3PO4-promoted oxidative cyclization has been developed for the facile synthesis of various functionalized quinazolin-4(3H)-ones from commercially available isatins and amidine hydrochlorides at room temperature. The synthetic utility of this strategy was illustrated by the convenient synthesis of tryptanthrin derivatives via a self-dimerization of isatins under the same conditions.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , Hubei, Wuhan 430079, P. R. China.
authors.forename: Feng-Cheng
authors.initials: FC
authors.lastname: Jia
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , Hubei, Wuhan 430079, P. R. China.
authors.forename: Zhi-Wen
authors.initials: ZW
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , Hubei, Wuhan 430079, P. R. China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Xu
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , Hubei, Wuhan 430079, P. R. China.
authors.forename: Yan-Dong
authors.initials: YD
authors.lastname: Wu
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , Hubei, Wuhan 430079, P. R. China.|State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.
authors.forename: An-Xin
authors.initials: AX
authors.lastname: Wu