title: Fat Decisions: Leptin Regulates Bone versus Fat in the Marrow.
abstract: Leptin is an adipocyte-derived hormone involved in energy sensing. In this issue of Cell Stem Cell, Yue et al. (2016) show that leptin is a physiologic signal that acts directly on Leptin-Receptor-expressing mesenchymal stromal cells in adult bone marrow to influence their lineage allocation in vivo, inhibiting bone formation and inducing marrow adipogenesis.
authors.affiliation: Department of Molecular, Cell and Developmental Biology, Yale University and the Section of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: matthew.rodeheffer@yale.edu.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Rodeheffer
authors.affiliation: Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT 06510, USA.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Horowitz
mesh_terms: D017667:Adipocytes / Q000187:drug effects; D050156:Adipogenesis / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects; D020738:Leptin; D059630:Mesenchymal Stem Cells / Q000187:drug effects
chemical_list: D020738:Leptin