title: Diabetes is associated with perforated appendicitis: evidence from a population-based study.
abstract: BACKGROUND
  The purpose of this study was to investigate the relationship between perforated appendicitis and patient with diabetes using a population-based data set.
  
  
  METHODS
  This study used data from the Longitudinal Health Insurance Database 2005 in Taiwan. We identified 4,806 patients hospitalized with acute appendicitis. The independent variable was whether a patient had ever received a diagnosis of diabetes before the index hospitalization. We performed a conditional logistic regression model to explore the odds ratio and its corresponding 95% confidence interval of perforated appendicitis.
  
  
  RESULTS
  Rates of perforated appendicitis for patients with and those without diabetes were 46.2% and 28.3%, respectively. A chi-square test revealed that there was a significant difference in rates of perforated appendicitis between patients with and those without diabetes (P < .001). The conditional logistic regression model revealed that the adjusted odds ratio of perforated appendicitis for patients with diabetes was 1.35 (95% confidence interval = 1.11 to 1.65) compared with patients without diabetes.
  
  
  CONCLUSIONS
  Our study demonstrated that a history of diabetes is an important factor with regard to the rate of perforated appendicitis.
authors.affiliation: Department of Surgery, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan; Cancer Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University, Taipei, Taiwan.
authors.forename: Po-Li
authors.initials: PL
authors.lastname: Wei
authors.affiliation: Sleep Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Herng-Ching
authors.initials: HC
authors.lastname: Lin
authors.affiliation: Sleep Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Li-Ting
authors.initials: LT
authors.lastname: Kao
authors.affiliation: School of Public Health, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Yi-Hua
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, No.280, Sec. 4, Ren'ai Rd., Da'an Dist., Taipei, Taiwan. Electronic address: czl@ntu.edu.tw.
authors.forename: Cha-Ze
authors.initials: CZ
authors.lastname: Lee
mesh_terms: D000328:Adult; D001064:Appendicitis / Q000453:epidemiology*; D016208:Databases, Factual; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
keywords: Appendix; Diabetes; Perforated appendicitis