title: Getting to the heart of an unusual kinetochore.
abstract: The Mis12 complex forms the central scaffold of the kinetochore and serves to bridge the chromatin and microtubule-binding activities of the inner and outer layers, respectively. Two recent studies provide new structural insights into the formation of this complex, and highlight some intriguing adaptations found in the Drosophila kinetochore.
authors.affiliation: Structural Biology of Chromosome Segregation Laboratory, The Francis Crick Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK martin.singleton@crick.ac.uk.
authors.forename: Martin R
authors.initials: MR
authors.lastname: Singleton
mesh_terms: D000818:Animals; D020090:Chromosome Segregation; D004331:Drosophila melanogaster / Q000378:metabolism; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism
chemical_list: D046912:Multiprotein Complexes