title: Bilirubin-Induced Audiologic Injury in Preterm Infants.
abstract: Although hyperbilirubinemia is extremely common among neonates and is usually mild and transient, it sometimes leads to bilirubin-induced neurologic damage (BIND). The auditory pathway is highly sensitive to the effects of elevated total serum/plasma bilirubin (TB) levels, with damage manifesting clinically as auditory neuropathy spectrum disorder. Compared to full-term neonates, preterm neonates are more susceptible to BIND and suffer adverse effects at lower TB levels with worse long-term outcomes. Furthermore, although standardized guidelines for management of hyperbilirubinemia exist for term and late preterm neonates, similar guidelines for neonates less than 35 weeks gestational age are limited.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Stanford University, 801 Welch Road, CA 94305, USA.
authors.forename: Cristen
authors.initials: C
authors.lastname: Olds
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, Stanford University, 801 Welch Road, CA 94305, USA. Electronic address: joghalai@stanford.edu.
authors.forename: John S
authors.initials: JS
authors.lastname: Oghalai
mesh_terms: D003056:Cochlear Nerve / Q000503:physiopathology*; D017626:Cochlear Nucleus / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D006313:Hearing Loss, Central / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D007231:Infant, Newborn; D007234:Infant, Premature; D007647:Kernicterus / Q000209:etiology / Q000503:physiopathology*
keywords: Auditory brainstem response; Auditory neuropathy; Bilirubin; Cochlea; Cochlear nucleus; Hyperbilirubinemia; Kernicterus; Preterm