title: [Pathogenesis of psoriasis].
abstract: Psoriasis is an inflammatory T cell-mediated autoimmune disease of skin and joints that affects 2-4 % of the adult population and 0.1-1 % of children. Genetic susceptibility, environmental triggering factors, and innate immune processes initiate psoriasis pathogenesis that results in an adaptive autoreactive response. The T cell response is orchestrated by CD 8(+) T cells in the epidermis and by CD 4(+) T cells in the dermis that predominantly produce interleukin-17 (IL‑17). Research of the past 15 years unraveled cellular and molecular mechanisms as well as cytokines like TNF-α or IL‑23 that contribute to psoriatic inflammation. This knowledge has been translated into clinical practice and a number of antipsoriatic small molecules and immunobiologics are now available. Here, we discuss the current principles of psoriasis pathogenesis in the context of modern therapies.
authors.affiliation: Hautklinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Schäkel
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologe, Universitätsmedizin Göttingen, Robert Koch Str. 40, 37075, Göttingen, Deutschland.
authors.forename: M P
authors.initials: MP
authors.lastname: Schön
authors.affiliation: Universitäts-Hautklinik, Universitätsklinikum Tübingen, Eberhard Karls Universität Tübingen, Liebermeisterstr. 25, 72076, Tübingen, Deutschland. kamran.ghoreschi@med.uni-tuebingen.de.
authors.forename: K
authors.initials: K
authors.lastname: Ghoreschi
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D016207:Cytokines / Q000235:genetics* / Q000276:immunology*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology; D055261:Immunogenetic Phenomena / Q000235:genetics; D007167:Immunotherapy / Q000379:methods; D008957:Models, Genetic; D018448:Models, Immunological; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology* / Q000628:therapy; D012867:Skin / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D016207:Cytokines
keywords: Autoimmune diseases; IL‑23; Inflammation; Skin; Th17