title: AOM/DSS Model of Colitis-Associated Cancer.
abstract: Our understanding of colitis-associated carcinoma (CAC) has benefited substantially from mouse models that faithfully recapitulate human CAC. Chemical models, in particular, have enabled fast and efficient analysis of genetic and environmental modulators of CAC without the added requirement of time-intensive genetic crossings. Here we describe the Azoxymethane (AOM)/Dextran Sodium Sulfate (DSS) mouse model of inflammatory colorectal cancer.
authors.affiliation: Department of Medicine, Division of Gastroenterology, Vanderbilt University, 1065D MRB-IV, B2215 Garland Avenue, Nashville, TN, 37232, USA.|Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA.
authors.forename: Bobak
authors.initials: B
authors.lastname: Parang
authors.affiliation: Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Caitlyn W
authors.initials: CW
authors.lastname: Barrett
authors.affiliation: Department of Medicine, Division of Gastroenterology, Vanderbilt University, 1065D MRB-IV, B2215 Garland Avenue, Nashville, TN, 37232, USA. Christopher.Williams@vanderbilt.edu.|Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA. Christopher.Williams@vanderbilt.edu.|Vanderbilt Ingram Cancer Center, Nashville, TN, USA. Christopher.Williams@vanderbilt.edu.|Veterans Affairs Tennessee Valley Health Care System, Nashville, TN, USA. Christopher.Williams@vanderbilt.edu.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Williams
mesh_terms: D000818:Animals; D001397:Azoxymethane; D003092:Colitis / Q000139:chemically induced* / Q000150:complications / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000139:chemically induced* / Q000473:pathology*; D016264:Dextran Sulfate; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice
chemical_list: D016264:Dextran Sulfate; D001397:Azoxymethane
keywords: AOM; Colitis-associated cancer; Colon cancer; DSS; Inflammatory carcinogenesis