title: Pubertal Height Growth and Adult Height in Cystic Fibrosis After Newborn Screening.
abstract: BACKGROUND
  To examine long-term growth benefit of newborn screening (NBS), adolescent peak height velocity (PHV), and adult height were compared between the screened (diagnosed early via NBS) and the control (identified generally by symptoms) in the Wisconsin Randomized Clinical Trial.
  
  
  METHODS
  Data from 107 children born in 1985-1994 and followed through 2012 were analyzed. PHV was estimated by a semiparametric growth curve model and compared with Tanner reference.
  
  
  RESULTS
  Meconium ileus (MI; n = 25) was associated with the worst pubertal growth and adult height, including 1 child who did not experience apparent PHV; children with pancreatic sufficiency (n = 18) achieved the best growth (normal PHV and adult height). In children with pancreatic insufficiency without meconium ileus (n = 64), the subgroup most likely to benefit from NBS, screened children had similar PHV but better adult height compared with controls. Specifically, in boys, the screened group (n = 22) achieved normal PHV (9.5 cm at 13.5 years); the control group (n = 19) had similar onset age (13.6 years) but 0.6-cm lower magnitude (P = .08). In girls, the screened group (n = 10) had somewhat later (12.5 years vs 11.7 years, P = .12) and lower PHV (7.3 cm vs 7.9 cm, P = .33) than the controls (n = 13), coinciding with later menarche (13.6 years vs 12.2 years, P = .10). Adult height was taller in the screened than the control (50th vs 29th percentile, P = .02), even after adjusted for genetic potential (32nd vs15th percentile, P = .006). Differences in adult height were primarily attributable to NBS and better prepubertal growth.
  
  
  CONCLUSIONS
  Early linear growth benefits of NBS were sustained through puberty, leading to better adult height in cystic fibrosis.
authors.affiliation: Departments of Nutritional Sciences.
authors.forename: Zhumin
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Biostatistics and Medical Informatics, and.
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Lindstrom
authors.affiliation: Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin.
authors.forename: Philip M
authors.initials: PM
authors.lastname: Farrell
authors.affiliation: Departments of Nutritional Sciences, Biostatistics and Medical Informatics, and Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin hlai@wisc.edu.
authors.forename: HuiChuan J
authors.initials: HJ
authors.lastname: Lai
mesh_terms: D000293:Adolescent; D000328:Adult; D001827:Body Height; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000503:physiopathology*; D010188:Exocrine Pancreatic Insufficiency / Q000503:physiopathology; D005260:Female; D006128:Growth; D006801:Humans; D045823:Ileus / Q000503:physiopathology; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D015997:Neonatal Screening; D011627:Puberty / Q000502:physiology*