title: Comparison of the effects of eldecalcitol with either raloxifene or bisphosphonate on serum tartrate resistant acid phosphatase-5b, a bone resorption marker, in postmenopausal osteoporosis.
abstract: OBJECTIVE
  This study analyzes whether concomitant raloxifene (RLX) or bisphosphonates (BP) plus eldecalcitol (ELD) has excessive suppressive effects on a bone resorption marker during the first 6 months of treatment in postmenopausal women in real-world setting.
  
  
  METHODS
  285 postmenopausal osteoporotic patients who had been treated with RLX or BP plus ELD were evaluated the bone resorption marker, serum tartrate resistant acid phosphatase-5b (TRACP-5b), during the first 6 months of treatment.
  
  
  RESULTS
  In drug-naïve group (not received osteoporosis medications before the administration, n=70), the concomitant RLX or BP with ELD significantly decreased levels of TRACP-5b without severe suppression. In vitamin D switch group [RLX or BP plus alfacalcidol (ALF) and then switched to RLX or BP plus ELD, n=215], the replacing ALF with ELD further and significantly decreased TRACP-5b and tertile analyses based on baseline values were significantly decreased far more in the highest, compared with the lowest tertile in the ELD+RLX and ELD+BP groups.
  
  
  CONCLUSIONS
  ELD combined with RLX or BP administered for 6 months to postmenopausal women with osteoporosis who were drug-naïve or who had switched medications significantly reduced and maintained TRACP-5b values within the reference range.
authors.affiliation: Kitago Orthopaedic Clinic, Sapporo, Hokkaido, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Takada
authors.affiliation: Department of Orthopaedic Surgery, Ken-Ai Memorial Hospital, Onga cho Fukuoka, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ikeda
authors.affiliation: Kusanagi Ladies Clinic, Sapporo, Hokkaido, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kusanagi
authors.affiliation: Hanakawa Orthopaedic Clinic, Ishikari, Hokkaido, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mizuno
authors.affiliation: Wada Women's Clinic, Asahikawa, Hokkaido, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wada
authors.affiliation: Department of Orthopaedic Surgery, Sapporo Medical University, Sapporo, Hokkaido, Japan.
authors.forename: Kousuke
authors.initials: K
authors.lastname: Iba
authors.affiliation: Kitago Orthopaedic Clinic, Sapporo, Hokkaido, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshizaki
authors.affiliation: Department of Orthopaedic Surgery, Sapporo Medical University, Sapporo, Hokkaido, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yamashita
keywords: bisphosphonate; bone metabolic marker; eldecalcitol; raloxifene; tartrate resistant acid phosphatase-5b (TRACP-5b)