title: Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour.
abstract: Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS but whether it plays a key role in inflammation-related behavioural changes remains unknown. Hence, in the present study we have examined whether PAR2 contributes to behaviour associated with systemic inflammation using PAR2 transgenic mice. The onset of sickness behaviour was delayed and the recovery accelerated in PAR2(-/-) mice in the LPS-induced model of sickness behaviour. In contrast, PAR2 does not contribute to behaviour under normal conditions. In conclusion, these data suggest that PAR2 does not contribute to behaviour in the normal healthy brain but it plays a role in inflammation-related behavioural changes.
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
authors.forename: Roua
authors.initials: R
authors.lastname: Abulkassim
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
authors.forename: Ros
authors.initials: R
authors.lastname: Brett
authors.affiliation: Institute of Cardiovascular and Medical Sciences, 126 University Place, University of Glasgow, Glasgow G12 8TA, UK.
authors.forename: Scott M
authors.initials: SM
authors.lastname: MacKenzie
authors.affiliation: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. Electronic address: trevor.bushell@strath.ac.uk.
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: Bushell
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000276:immunology; D005106:Exploratory Behavior / Q000502:physiology; D005518:Food Preferences / Q000502:physiology; D005786:Gene Expression Regulation / Q000187:drug effects; D055809:Illness Behavior / Q000187:drug effects / Q000502:physiology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D012333:RNA, Messenger / Q000378:metabolism; D044464:Receptor, PAR-2 / Q000235:genetics / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013395:Sucrose / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D008070:Lipopolysaccharides; D012333:RNA, Messenger; D044464:Receptor, PAR-2; D013395:Sucrose
keywords: Anxiety; LPS; Locomotor activity; Proteinase-activated receptor-2; Sickness behaviour; Sucrose preference