title: Endoperoxy and hydroperoxy cadinane-type sesquiterpenoids from an Okinawan soft coral, Sinularia sp.
abstract: Three cadinane-type sesquiterpenoids, endoperoxide (1) and hydroperoxides (2, 3) together with three known sesquiterpenoids (4-6) were isolated from an Okinawan soft coral, Sinularia species. Structures of these isolates were elucidated by spectroscopic analyses (NMR, IR and MS) and molecular modeling. In addition, the isolates 1-3 as new compounds were examined for biological activities, resulting that they have antibacterial activity and weak cytotoxicity against HCT116 cells as well as anti-inflammatory effect on LPS/IFN-γ-stimulated RAW 264.7 macrophage cells.
authors.affiliation: Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-Cho, Okinawa, 903-2013, Japan. prodipkroy@gmail.com.
authors.forename: Prodip K
authors.initials: PK
authors.lastname: Roy
authors.affiliation: Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-Cho, Okinawa, 903-2013, Japan.
authors.forename: Runa
authors.initials: R
authors.lastname: Ashimine
authors.affiliation: Department of Bioresources Engineering, Okinawa National College of Technology, 905 Henoko, Nago-Shi, Okinawa, 905-2192, Japan.
authors.forename: Haruna
authors.initials: H
authors.lastname: Miyazato
authors.affiliation: Department of Bioresources Engineering, Okinawa National College of Technology, 905 Henoko, Nago-Shi, Okinawa, 905-2192, Japan.
authors.forename: Junsei
authors.initials: J
authors.lastname: Taira
authors.affiliation: Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-Cho, Okinawa, 903-2013, Japan. kueda@sci.u-ryukyu.ac.jp.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Ueda
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery / Q000379:methods*; D004926:Escherichia coli / Q000187:drug effects; D045325:HCT116 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D000081223:Polycyclic Sesquiterpenes; D019779:Salmonella enterica / Q000187:drug effects; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C508039:cadinane; D009569:Nitric Oxide
keywords: Anti-inflammatory; Cadinane; Cytotoxicity; HCT 116 cells; Sesquiterpenoid; Sinularia