title: Test-retest reliability of rapid whole body and compartmental fat volume quantification on a widebore 3T MR system in normal-weight, overweight, and obese subjects.
abstract: To measure the test-retest reliability of rapid (<15 min) whole body and visceral fat volume quantification in normal and obese subjects on a widebore 3T MR system and compare it with conventional manual segmentation.
  
  
  
  Thirty participants (body mass index [BMI] 20.1-48.6 kg/m2) underwent two whole-body magnetic resonance imaging (MRI) examinations on a widebore 3T machine using a 2-point Dixon technique. Phase sensitive reconstruction and intensity inhomogeneity correction produced quantitative datasets of total adipose tissue (TAT), abdominal subcutaneous adipose tissue (ASAT), and visceral adipose tissue (VAT). The quantification was performed automatically using nonrigid atlas-based segmentation and compared with manual segmentation (SliceOmatic).
  
  
  
  The mean TAT was 31.74 L with a coefficient of variation (CV) of 0.79% and a coefficient of repeatability (CR) of 0.49 L. The ASAT was 7.92 L with a CV of 2.98% and a CR of 0.46 L. There was no significant difference in the semiautomated and manually segmented VAT (P = 0.73) but there were differences in the reliability of the two techniques. The mean semiautomated VAT was 2.56 L, CV 1.8%, and CR 0.09 L compared to the mean manually segmented VAT of 3.12 L, where the CV was 6.3% and the CR was 0.39 L.
  
  
  
  Rapid semiautomated whole body and compartmental fat volume quantification can be derived from a widebore 3T system, for a range of body sizes including obese patients, with "almost perfect" test-retest reliability. J. Magn. Reson. Imaging 2016;44:1464-1473.
authors.affiliation: Department of Radiology, Norfolk & Norwich University Hospital, UK.
authors.forename: David
authors.initials: D
authors.lastname: Newman
authors.affiliation: Department of Radiology, Norfolk & Norwich University Hospital, UK.
authors.forename: Christian
authors.initials: C
authors.lastname: Kelly-Morland
authors.affiliation: Center for Medical Image Science and Visualisation, Linköping University, Sweden.|Department of Medical and Health Sciences, Linköping University, Sweden.|Advanced MR Analytics AB, Linköping, Sweden.
authors.forename: Olof Dahlqvist
authors.initials: OD
authors.lastname: Leinhard
authors.affiliation: Department of Radiology, Norfolk & Norwich University Hospital, UK.
authors.forename: Bahman
authors.initials: B
authors.lastname: Kasmai
authors.affiliation: Department of Radiology, Norfolk & Norwich University Hospital, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: Greenwood
authors.affiliation: Department of Radiology, Norfolk & Norwich University Hospital, UK.
authors.forename: Paul N
authors.initials: PN
authors.lastname: Malcolm
authors.affiliation: Center for Medical Image Science and Visualisation, Linköping University, Sweden.|Advanced MR Analytics AB, Linköping, Sweden.|Department of Biomedical Engineering, Linköping University, Sweden.
authors.forename: Thobias
authors.initials: T
authors.lastname: Romu
authors.affiliation: Center for Medical Image Science and Visualisation, Linköping University, Sweden.|Advanced MR Analytics AB, Linköping, Sweden.|Department of Biomedical Engineering, Linköping University, Sweden.
authors.forename: Magnus
authors.initials: M
authors.lastname: Borga
authors.affiliation: Department of Radiology, Norfolk & Norwich University Hospital, UK.
authors.forename: Andoni P
authors.initials: AP
authors.lastname: Toms
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000000981:diagnostic imaging* / Q000473:pathology*; D015588:Observer Variation; D009929:Organ Size; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D051598:Whole Body Imaging / Q000379:methods*
keywords: MRI; adipose; manual segmentation; reliability; semiautomated quantification; visceral adipose