title: Monoterpenes and sesquiterpenes from the marine sediment-derived fungus Eutypella scoparia FS46.
abstract: Eutypellol A (1), the first norsesquiterpenoid of sequicarene family, as well as eutypellol B (2), a rare 7-methyl oxidized 2-carene derivative, and one new natural product 2-(2-hydroxy-4-methylcyclohex-3-enyl)propanoic acid (3), along with eight known terpenoids, were isolated from the marine sediment-derived fungus Eutypella scoparia FS46 collected from the South China Sea. Their structures were established on the basis of extensive spectroscopic analysis. Compounds 1-3 were evaluated for their antibacterial activities against Staphylococcus aureus and cytotoxic activities against MCF-7, NCI-H460, and SF-268 tumor cell lines.
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou 510070 , China.
authors.forename: Hong-Xin
authors.initials: HX
authors.lastname: Liu
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou 510070 , China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou 510070 , China.
authors.forename: Yu-Chan
authors.initials: YC
authors.lastname: Chen
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou 510070 , China.
authors.forename: Zhang-Hua
authors.initials: ZH
authors.lastname: Sun
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou 510070 , China.
authors.forename: Qing-Ling
authors.initials: QL
authors.lastname: Pan
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou 510070 , China.
authors.forename: Hao-Hua
authors.initials: HH
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou 510070 , China.
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019015:Geologic Sediments; D006801:Humans; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D039821:Monoterpenes; D012717:Sesquiterpenes; C000616014:eutypellol A; C000616015:eutypellol B
keywords: Eutypella scoparia; eutypellol A; eutypellol B