title: Exploiting Laboratory Insights to Improve Outcomes of Pediatric Central Nervous System Tumors.
abstract: Over a relatively short period of time, owing to improvements in biotechnology, our ability to identify the molecular mechanisms within pediatric brain tumors has dramatically increased. These findings have reshaped the way that we describe these diseases and have provided insights into how to better treat these often devastating diseases. Although still far from reaching the full therapeutic potential these advancements hold, the impact of these findings is steadily taking hold of pediatric brain tumor management. In this article, we summarize the major discoveries within three common pediatric brain tumor categories; medulloblastoma, ependymoma, and low-grade glioma. We discuss the current impact of these findings on treatment and the direction these findings may take the field of pediatric neuro-oncology.
authors.affiliation: From the Division of Neuro-Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN; Division of Pediatric Neurooncology, German Cancer Research Center, Heidelberg, Germany; Center for Data Driven Discovery in Biomedicine, Division of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA.
authors.forename: Giles W
authors.initials: GW
authors.lastname: Robinson
authors.affiliation: From the Division of Neuro-Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN; Division of Pediatric Neurooncology, German Cancer Research Center, Heidelberg, Germany; Center for Data Driven Discovery in Biomedicine, Division of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Witt
authors.affiliation: From the Division of Neuro-Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN; Division of Pediatric Neurooncology, German Cancer Research Center, Heidelberg, Germany; Center for Data Driven Discovery in Biomedicine, Division of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA.
authors.forename: Adam
authors.initials: A
authors.lastname: Resnick
mesh_terms: D001932:Brain Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology; D016543:Central Nervous System Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000235:genetics / Q000473:pathology; D002648:Child; D004806:Ependymoma / Q000235:genetics / Q000473:pathology; D005910:Glioma / Q000235:genetics / Q000473:pathology; D006801:Humans; D008527:Medulloblastoma / Q000235:genetics / Q000473:pathology; D010372:Pediatrics