title: Nucleophilic Nitration of Arynes by Sodium Nitrite and its Multicomponent Reaction Leading to Double-Functionalized Arenes.
abstract: An unusual nucleophilic nitration of arynes by NaNO2 in the presence of water has been developed, and the concept was further demonstrated to accomplish a double functionalization of arynes using a multicomponent reaction protocol to synthesize pharmaceutically important (2-nitrophenyl)methanol derivatives. Such substitution ortho to -NO2 is difficult by other means. The reaction conditions are mild and avoid the use of strong acids, expensive transition metal catalysts, and additives.
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Pune 411 008, India.
authors.forename: Ranjeet A
authors.initials: RA
authors.lastname: Dhokale
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Pune 411 008, India.
authors.forename: Santosh B
authors.initials: SB
authors.lastname: Mhaske