title: Efficacy of Trimetazidine Dihydrochloride for Relieving Chronic Tinnitus: A Randomized Double-Blind Study.
abstract: OBJECTIVE
  To evaluate the efficacy of trimetazidine dihydrochloride as a treatment for chronic tinnitus.
  
  
  METHODS
  A total of 97 chronic tinnitus patients were evaluated in this randomized, prospective, double-blind, placebo-controlled trial. After assessing for eligibility, 82 patients were randomly assigned into placebo or trimetazidine groups according to the medication. The trimetazidine group received 20×3 mg/day per oral trimetazidine dihydrochloride and the placebo group received 20×3 mg/day per oral placebo for 3 months. Tinnitus handicap inventory (THI), visual analogue scale (VAS) questionnaires and audiometric results were used to determine the effectiveness of trimetazidine treatment.
  
  
  RESULTS
  The study group comprised 82 tinnitus subjects, 42 (51%) of whom received trimetazidine dihydrochloride and 40 (49%) who received placebo. There was no significant difference between placebo and trimetazidine groups in THI grade and VAS (both pre- and posttreatment scores) (P>0.05) and no significant improvement was observed in subjective loudness score in either group (P>0.05). Additionally there was no significant difference between groups in pre- and posttreatment pure tone hearing thresholds at all measured frequencies (P>0.05).
  
  
  CONCLUSIONS
  Trimetazidine dihydrochloride therapy was ineffective for relieving chronic tinnitus.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: Tolgar Lütfi
authors.initials: TL
authors.lastname: Kumral
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: Güven
authors.initials: G
authors.lastname: Yıldırım
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: Güler
authors.initials: G
authors.lastname: Berkiten
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ziya
authors.initials: Z
authors.lastname: Saltürk
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: Enes
authors.initials: E
authors.lastname: Ataç
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Atar
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Uyar
keywords: Drug treatment; Tinnitus; Trimetazidine dihydrochloride