title: Replicating repetitive DNA.
abstract: The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particular during replication stress.
authors.affiliation: DNA Replication Group, Institute of Clinical Sciences, Imperial College London, London, W12 0NN, UK.|MRC Clinical Sciences Centre, Du Cane Road, London, W12 0NN, UK.|Cell Signalling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Tognetti
authors.affiliation: DNA Replication Group, Institute of Clinical Sciences, Imperial College London, London, W12 0NN, UK.|MRC Clinical Sciences Centre, Du Cane Road, London, W12 0NN, UK.
authors.forename: Christian
authors.initials: C
authors.lastname: Speck
mesh_terms: D000818:Animals; D002503:Centromere / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004261:DNA Replication; D006801:Humans; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D014982:Xenopus laevis
chemical_list: D004247:DNA