title: Dengue Specific Immunoglobulin A Antibody is Present in Urine and Associated with Disease Severity.
abstract: The kinetics of dengue virus (DENV)-specific IgA antibody in urine and the potential correlation with disease severity remain elusive. In this study, 262 serial urine samples from 78 laboratory-confirmed patients were assayed by a commercial immunoglobulin A (IgA) kit against DENV. All cases were classified into dengue fever (DF) and severe dengue (SD) according to the 2009 WHO/TDR guideline. The total positive rate of IgA in urine was 59%. DENV-specific IgA was detected in urine from day 2 to day 13 after the onset of illness in DF patients; While for SD patients, anti-DENV IgA could be detected till day 14. The positive rate of IgA in patients with secondary infection was higher than that in patients with primary infection. Importantly, during 4-7 days after the onset of illness, the IgA positive rate of SD patients was significantly higher than that of DF patients. Especially, the intensity of IgA signal in SD patients was obviously stronger than that in DF patient at the recovery stage. Overall, our results suggested that the existence of DENV-specific IgA antibodies in urine might be a warning sign for the severity of disease and its measurement might provide valuable guidance for proper patient management.
authors.affiliation: Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, People's Republic of China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Qiu
authors.affiliation: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, People's Republic of China.
authors.forename: Wen-Xin
authors.initials: WX
authors.lastname: Hong
authors.affiliation: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, People's Republic of China.
authors.forename: Ke-Yu
authors.initials: KY
authors.lastname: Song
authors.affiliation: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, People's Republic of China.
authors.forename: Hui-Qin
authors.initials: HQ
authors.lastname: Yang
authors.affiliation: Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, People's Republic of China.
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Deng
authors.affiliation: Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, People's Republic of China.
authors.forename: Shun-Ya
authors.initials: SY
authors.lastname: Zhu
authors.affiliation: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, People's Republic of China.
authors.forename: Fu-Chun
authors.initials: FC
authors.lastname: Zhang
authors.affiliation: Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, People's Republic of China.
authors.forename: Cheng-Feng
authors.initials: CF
authors.lastname: Qin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000652:urine*; D002681:China; D003715:Dengue / Q000276:immunology* / Q000473:pathology*; D003716:Dengue Virus / Q000276:immunology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000652:urine*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007070:Immunoglobulin A