title: [The application of in vivo multi-channel recording methods in the studies of the affective pain in rats].
abstract: OBJECTIVE
  To record the electrical activities of Antirior cingulate cortex (ACC) neurons by in vivo multi-channel recording methods using the model of complete freund's adjuvant (CFA) induced conditioned place avoidance (C-CPA), which has been set up in our previous studies.
  
  
  METHODS
  The electrode was self-made and the CPA responses were recorded by in vivo multi-channel recording method.
  
  
  RESULTS
  (1) The electrical activities of ACC neurons could be successfully recorded by the self-made electrode. (2) Before or after the injection of CFA, rats were respectively conditioned to the different place. The firing rates of ACC neurons in the CFA-paired place vs that in the non-CFA-paired place was (0.853 ± 1.377) imp/s vs (0.221 ± 0.971) imp/s (P < 0.05, n = 26). (3) The CPA responses in the CFA-paired place vs that in the non-CFA-paired place were (303.55 ± 61.77)s vs (140.32 ± 33.52)s(P < 0.05, n = 6).
  
  
  CONCLUSIONS
  The firing rates of rACC (rostral Anterior Cingulate Cortex) neurons were involved in the occurrence of the affective pain.
authors.forename: Zhen-hua
authors.initials: ZH
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Miao-miao
authors.initials: MM
authors.lastname: Hou
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Xia
authors.initials: X
authors.lastname: Qin
authors.forename: Che
authors.initials: C
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004566:Electrodes; D005620:Freund's Adjuvant; D006179:Gyrus Cinguli / Q000166:cytology*; D009474:Neurons / Q000166:cytology*; D010146:Pain / Q000175:diagnosis*; D010147:Pain Measurement / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005620:Freund's Adjuvant