title: Total synthesis of xiamenmycin C and all of its stereoisomers: stereochemical revision.
abstract: Xiamenmycin C, a potent anti-fibrotic natural product, and all of its stereoisomers have been synthesized and their structures were fully characterized. Based on this study, the originally proposed structure of xiamenmycin C has been accordingly revised to be 2R,3S.
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation , Institute of Materia Medica, Chinese Academy of Medical Science & Pecking Union Medical College , Beijing 100050 , China.
authors.forename: Yang-Yang
authors.initials: YY
authors.lastname: Yao
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation , Institute of Materia Medica, Chinese Academy of Medical Science & Pecking Union Medical College , Beijing 100050 , China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Liu
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation , Institute of Materia Medica, Chinese Academy of Medical Science & Pecking Union Medical College , Beijing 100050 , China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation , Institute of Materia Medica, Chinese Academy of Medical Science & Pecking Union Medical College , Beijing 100050 , China.
authors.forename: Hong-Guang
authors.initials: HG
authors.lastname: Yang
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation , Institute of Materia Medica, Chinese Academy of Medical Science & Pecking Union Medical College , Beijing 100050 , China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation , Institute of Materia Medica, Chinese Academy of Medical Science & Pecking Union Medical College , Beijing 100050 , China.
authors.forename: Xiao-Zhen
authors.initials: XZ
authors.lastname: Jiao
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation , Institute of Materia Medica, Chinese Academy of Medical Science & Pecking Union Medical College , Beijing 100050 , China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D013912:Threonine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D001578:Benzopyrans; D001688:Biological Products; C582113:N-((3,4-dihydro-3-hydroxy-2-methyl-2-(4'-methyl-3'-pentenyl)-2H-1-benzopyran-6-yl)carbonyl)threonine; D013912:Threonine
keywords: Xiamenmycin C; stereochemical revision; total synthesis