title: A new sesquiterpene from the South China Sea gorgonian coral Subergorgia suberosa.
abstract: A new sesquiterpene, namely suberosoid (1), was isolated from the South China Sea gorgonian coral Subergorgia suberosa. The chemical structure of 1 was established as an unusual sesquiterpene containing 4-methylenecyclohex-2-enone system, by extensive analyses of NMR spectroscopy and high-resolution mass spectrometry. Suberosoid (1) exhibited cytotoxic effect against HeLa cell lines with IC50 value being 10.6 μM.
authors.affiliation: a School of Public Health , Sun Yat-Sen University , Guangzhou , P.R. China.
authors.forename: Mu-Wu
authors.initials: MW
authors.lastname: Xu
authors.affiliation: a School of Public Health , Sun Yat-Sen University , Guangzhou , P.R. China.
authors.forename: Yuan-Tao
authors.initials: YT
authors.lastname: Hao
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C000617376:suberosoid
keywords: Gorgonian coral; Subergorgia suberosa; cytotoxicity; sesquiterpene