title: Microfluidic nanoprecipitation systems for preparing pure drug or polymeric drug loaded nanoparticles: an overview.
abstract: BACKGROUND
  This review gives an overview of the different microfluidic setups used to produce either pure drug or drug-loaded polymeric nanoparticles.
  
  
  METHODS
  We propose a description of the different fluidic principles reported in the literature, explaining their respective design and configuration in parallel with the technical challenges related to the nanoprecipitation of the polymer, in relation with the results obtained, e.g., particle size, distribution and productivity.
  
  
  CONCLUSIONS
  This review is mostly intended for a broad readership and provides key tools regarding the choice of microfluidic setups, tailored to given specifications. We discuss the specificities and geometries of the microfluidic devices intended to nanoprecipitation, advantages, drawbacks and limitations.
authors.affiliation: a Institut Charles Sadron (ICS) - UPR 22 CNRS , Strasbourg , France.
authors.forename: Shukai
authors.initials: S
authors.lastname: Ding
authors.affiliation: b Laboratoire de Conception et Application de Molécules Bioactives (CAMB) - UMR 7199 CNRS , Equipe de Pharmacie Biogalénique , Strasbourg , France.|c Faculté de Pharmacie , Université de Strasbourg (Unistra) , Strasbourg , France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Anton
authors.affiliation: b Laboratoire de Conception et Application de Molécules Bioactives (CAMB) - UMR 7199 CNRS , Equipe de Pharmacie Biogalénique , Strasbourg , France.|c Faculté de Pharmacie , Université de Strasbourg (Unistra) , Strasbourg , France.
authors.forename: Thierry F
authors.initials: TF
authors.lastname: Vandamme
authors.affiliation: a Institut Charles Sadron (ICS) - UPR 22 CNRS , Strasbourg , France.|d École Européenne de Chimie, Polymères et Matériaux (ECPM) , Université de Strasbourg (Unistra) , Strasbourg , France.
authors.forename: Christophe A
authors.initials: CA
authors.lastname: Serra
mesh_terms: D044085:Microfluidics; D053758:Nanoparticles; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*
chemical_list: D011108:Polymers
keywords: Microfluidic system; drug; drug loaded; nanoparticles; nanoprecipitation; polymer