title: Clonal spread of blaOXA-72-carrying Acinetobacter baumannii sequence type 512 in Taiwan.
abstract: This is the first report to show an insidious outbreak of armA- and blaOXA-72-carrying Acinetobacter baumannii sequence type 512 (ST512) at a study hospital in northern Taiwan. Multilocus sequence typing revealed that this was a ST512 clone. All of the isolates with ST512 carried a novel 12,056-bp repGR2 in combination with a repGR12-type plasmid. This plasmid, designated pAB-ML, had one copy of the blaOXA-72 gene that was flanked by XerC/XerD-like sites and conferred resistance to carbapenems.
authors.affiliation: Department of Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu City, Taiwan; School of Medicine, National Taiwan University, Taipei City, Taiwan.
authors.forename: Han-Yueh
authors.initials: HY
authors.lastname: Kuo
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, Yuanpei University, Hsin-Chu City, Taiwan.
authors.forename: Po-Jui
authors.initials: PJ
authors.lastname: Hsu
authors.affiliation: Department of Laboratory Medicine, Taipei Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan.
authors.forename: Jiann-Yuan
authors.initials: JY
authors.lastname: Chen
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, Yuanpei University, Hsin-Chu City, Taiwan.
authors.forename: Po-Cheng
authors.initials: PC
authors.lastname: Liao
authors.affiliation: Institute of Biotechnology, National Taiwan University, Taipei, Taiwan.
authors.forename: Chia-Wei
authors.initials: CW
authors.lastname: Lu
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Changhua City, Taiwan; Center for Infectious Diseases Research, Changhua Christian Hospital, Changhua City, Taiwan; Department of Nursing, College of Medicine & Nursing, Hung Kuang University, Taichung, Taiwan. Electronic address: 76590@cch.org.tw.
authors.forename: Chang-Hua
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, Yuanpei University, Hsin-Chu City, Taiwan. Electronic address: d918229@gmail.com.
authors.forename: Ming-Li
authors.initials: ML
authors.lastname: Liou
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000032:analysis* / Q000235:genetics; D015780:Carbapenems / Q000494:pharmacology; D004196:Disease Outbreaks; D006801:Humans; D058885:Multilocus Sequence Typing; D010957:Plasmids / Q000032:analysis* / Q000145:classification; D013624:Taiwan / Q000453:epidemiology; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000032:analysis* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; C000596363:OXA-72 carbapenemase, Acinetobacter baumannii; D001618:beta-Lactamases
keywords: Acinetobacter baumannii; ST512; bla(OXA-72)