title: Diffusion-weighted MRI in Crohn's disease: Current status and recommendations.
abstract: Over the past years, technological improvements and refinements in magnetic resonance imaging (MRI) hardware have made high-quality diffusion-weighted imaging (DWI) routinely possible for the bowel. DWI is promising for the detection and characterization of lesions in Crohn's disease (CD) and has been advocated as an alternative to intravenous gadolinium-based contrast agents. Furthermore, quantification using the apparent diffusion coefficient may have value as a biomarker of CD activity and has shown promise. In this article we critically review the literature pertaining to the value of DWI in CD for detection, characterization, and quantification of disease activity and complications. Although the body of supportive evidence is growing, it is clear that well-designed, multicenter studies are required before the role of DWI in clinical practice can be fully established. J. Magn. Reson. Imaging 2016;44:1381-1396.
authors.affiliation: McGill University Health Center, Department of Radiology, McGill University Health Center, Montreal, QC, Canada.|Department of Body and Interventional Imaging, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.|Université Paris-Diderot, Sorbonne Paris Cité, Paris, France.|INSERM UMR 965, Paris, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Dohan
authors.affiliation: Centre for Medical Imaging, University College London, Podium Level 2, University College Hospital, London, UK.
authors.forename: Stuart
authors.initials: S
authors.lastname: Taylor
authors.affiliation: Department of Radiology, Hôpital Robert-Debré, Reims, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Hoeffel
authors.affiliation: Department of Gastroenterology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Maximilien
authors.initials: M
authors.lastname: Barret
authors.affiliation: Université Paris-Diderot, Sorbonne Paris Cité, Paris, France.|Department of Gastroenterology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Allez
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Raphael
authors.initials: R
authors.lastname: Dautry
authors.affiliation: Department of Radiology, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France.
authors.forename: Magaly
authors.initials: M
authors.lastname: Zappa
authors.affiliation: Department of Radiology, CHU Charles Nicolle, Rouen, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Savoye-Collet
authors.affiliation: Université Paris-Diderot, Sorbonne Paris Cité, Paris, France.|Department of Gastroenterology, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Dray
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Mourad
authors.initials: M
authors.lastname: Boudiaf
authors.affiliation: McGill University Health Center, Department of Radiology, McGill University Health Center, Montreal, QC, Canada.
authors.forename: Caroline
authors.initials: C
authors.lastname: Reinhold
authors.affiliation: Department of Body and Interventional Imaging, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.|Université Paris-Diderot, Sorbonne Paris Cité, Paris, France.|INSERM UMR 965, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Soyer
mesh_terms: D003424:Crohn Disease / Q000000981:diagnostic imaging* / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D019317:Evidence-Based Medicine; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: Crohn's Disease; MR imaging; MR-enterography; diffusion weighted imaging; imaging techniques; inflammatory bowel disease