title: [Immunoglobulin G4-related lung disease: Case report and literature review].
abstract: We report the case of a 61-year-old man with a pulmonary nodule discovered while staging the metastasis of a squamous cell carcinoma. No primary cancer was found. Histological examination of the resected specimen (lingula) was in favor of IgG4-related inflammatory pseudotumor. Histological criteria were described in 2012, combining a dense lymphoplasmacitic infiltrate rich in IgG4-positive plasma cell, storiform fibrosis and obliterative phlebitis. IgG4/IgG plama cell ratio>40 % is mandatory for histological diagnosis of IgG4-related disease. This is a rare and often underdiagnosed disease. Diagnostic criteria are now defined and consensual, combining clinical signs, biology and histology.
authors.affiliation: Service de pathologie, hôpital Henri-Duffaut, centre hospitalier d'Avignon, 84000 Avignon, France. Electronic address: cl.delteil@gmail.com.
authors.forename: Clémence
authors.initials: C
authors.lastname: Delteil
authors.affiliation: Service de pathologie, hôpital Henri-Duffaut, centre hospitalier d'Avignon, 84000 Avignon, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Chesnais
authors.affiliation: Service de pathologie, hôpital Henri-Duffaut, centre hospitalier d'Avignon, 84000 Avignon, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Tasei
authors.affiliation: Service de pathologie, hôpital Henri-Duffaut, centre hospitalier d'Avignon, 84000 Avignon, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Cohen-Pansieri
authors.affiliation: Service de chirurgie vasculaire et thoracique, hôpital Henri-Duffaut, centre hospitalier d'Avignon, 84000 Avignon, France.
authors.forename: Nidal
authors.initials: N
authors.lastname: Naffaa
authors.affiliation: Service de pathologie, hôpital Henri-Duffaut, centre hospitalier d'Avignon, 84000 Avignon, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Granier
mesh_terms: D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008171:Lung Diseases / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged
chemical_list: D007074:Immunoglobulin G
keywords: Characteristic histopathological features; Critères diagnostiques histologiques; Forme pseudotumorale pulmonaire; IgG4-related disease (IgG4-RD); Inflammatory pulmonary pseudotumor; Maladie à IgG4