title: Therapeutic Cancer Vaccines.
abstract: Cancer is one of the major leading death causes of diseases. Prevention and treatment of cancer is an important way to decrease the incidence of tumorigenesis and prolong patients' lives. Subversive achievements on cancer immunotherapy have recently been paid much attention after many failures in basic and clinical researches. Based on deep analysis of genomics and proteomics of tumor antigens, a variety of cancer vaccines targeting tumor antigens have been tested in preclinical and human clinical trials. Many therapeutic cancer vaccines alone or combination with other conventional treatments for cancer obtained spectacular efficacy, indicating the tremendously potential application in clinic. With the illustration of underlying mechanisms of cancer immune regulation, valid, controllable, and persistent cancer vaccines will play important roles in cancer treatment, survival extension and relapse and cancer prevention. This chapter mainly summarizes the recent progresses and developments on cancer vaccine research and clinical application, thus exploring the existing obstacles in cancer vaccine research and promoting the efficacy of cancer vaccine.
authors.affiliation: Laboratory of Viral and Gene Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China.
authors.forename: Zhenlong
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Laboratory of Viral and Gene Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Li
authors.affiliation: Laboratory of Viral and Gene Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China. hj-jin@hotmail.com.
authors.forename: Huajun
authors.initials: H
authors.lastname: Jin
authors.affiliation: Laboratory of Viral and Gene Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China. qianqj@163.com.
authors.forename: Qijun
authors.initials: Q
authors.lastname: Qian
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D019496:Cancer Vaccines / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy / Q000379:methods*; D004195:Disease Models, Animal; D015972:Gene Expression Regulation, Neoplastic / Q000276:immunology*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007167:Immunotherapy / Q000379:methods; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents; D019496:Cancer Vaccines; D007155:Immunologic Factors; D015514:Oncogene Proteins, Fusion
keywords: Adjuvant; Cancer vaccine; Combination therapy; Immunotherapy; Therapeutic cancer vaccine