title: [ROLE OF INNATE IMMUNITY FACTORS IN PERIODONTITIS PATHOGENESIS].
abstract: Chronic generalized periodontitis (CGP) is a disease of periodontium tissues supporting tooth induced by bacteria, that is characterized by the presence of processes of inflammation with destruction of bone tissue. The knowledge of molecular mechanisms of CGP pathogenesis facilitates creation of the most effective methods of therapy of this disease. Bacterial infection is a primary factor in periodontitis etiology, however is not sufficient for its start and subsequent development. It is known, that bacterial factors induce alocal inflammationreaction and.activate the system of innate immunity through activation of Toll-like receptors (TLR), located on the surface of resident cells and leukocytes. Activation of these cells results in production of pro-inflammatory cytokines and recruitment of phagocytes and lymphocytes into the inflammation zone. In review we examined the known data regarding factors of immune protection of periodontium including cell populations and cytokines, as well as mechanisms of tissue destruction, that support the tooth. Perspectives of therapy are also discussed
authors.forename: L V
authors.initials: LV
authors.lastname: Gankovskaya
authors.forename: N M
authors.initials: NM
authors.lastname: Khelminskaya
authors.forename: E A
authors.initials: EA
authors.lastname: Molchanova
authors.forename: O A
authors.initials: OA
authors.lastname: Svitich
mesh_terms: D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology / Q000473:pathology; D016207:Cytokines / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D007249:Inflammation / Q000235:genetics* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D008214:Lymphocytes / Q000378:metabolism; D010518:Periodontitis / Q000235:genetics* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D010519:Periodontium / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D010586:Phagocytes / Q000276:immunology / Q000378:metabolism; D051193:Toll-Like Receptors / Q000235:genetics* / Q000378:metabolism
chemical_list: D016207:Cytokines; D051193:Toll-Like Receptors