title: Complications of Treatment in Youth with HIV.
abstract: While combination antiretroviral therapy allows HIV-infected patients to have life expectancies similar to that of the general population, it may also contribute to the development of co-morbidities, such as cardiovascular disease and osteoporosis. Such complications could compromise long-term quality of life, especially in HIV-infected youth whose lifetime cumulative exposure to antiretrovirals is likely to be many decades. Recent studies continue to demonstrate abnormalities associated with antiretroviral therapy, although clinical manifestations are rare in this younger population, especially with modern antiretrovirals. The purpose of this paper is to review the most recent literature on complications of treatment in youth with HIV.
authors.affiliation: Division of Infectious Diseases, Medical University of South Carolina, 135 Rutledge Ave, Ste 1217, MSC 752, Charleston, SC, 29425, USA. eckarda@musc.edu.
authors.forename: Allison Ross
authors.initials: AR
authors.lastname: Eckard
authors.affiliation: Division of Infectious Diseases, Medical University of South Carolina, 135 Rutledge Ave, Ste 1217, MSC 752, Charleston, SC, 29425, USA.
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Fowler
authors.affiliation: Division of Infectious Diseases, Medical University of South Carolina, 135 Rutledge Ave, Ste 1217, MSC 752, Charleston, SC, 29425, USA.
authors.forename: Julia C
authors.initials: JC
authors.lastname: Haston
authors.affiliation: Division of Infectious Diseases, Medical University of South Carolina, 135 Rutledge Ave, Ste 1217, MSC 752, Charleston, SC, 29425, USA.
authors.forename: Terry C
authors.initials: TC
authors.lastname: Dixon
mesh_terms: D000293:Adolescent; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D002318:Cardiovascular Diseases / Q000453:epidemiology; D015897:Comorbidity; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D010024:Osteoporosis / Q000453:epidemiology; D011788:Quality of Life
chemical_list: D019380:Anti-HIV Agents
keywords: Antiretroviral therapy; Complications; HIV; HIV-exposed infants; Pediatrics and adolescence