title: TLR2 modulates gut colonization and dissemination of Candida albicans in a murine model.
abstract: Invasive candidiasis often arises from translocation of endogenous yeasts from the gastrointestinal tract to the bloodstream. Here we describe that both wild type and TLR2-/- mice strains, orally administered with Candida albicans yeasts, display similar sustained high level of gut colonization when oral antibacterial treatment is present, while removal of antibiotic treatment causes a progressive clearance of yeasts in control but not in TLR2-/- mice. Fungal invasion of internal organs, following immunosuppression of colonized mice, was increased in TLR2-/- mice. These results point out to a role of TLR2 in gut protection against colonization and endogenous invasion by C. albicans.
authors.affiliation: Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Prieto
authors.affiliation: Departamento de Microbiología y Ecología, Universitat de València, Burjassot, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Carpena
authors.affiliation: Departamento de Óptica, Farmacología y Anatomía, Universidad de Alicante, Alicante, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: Maneu
authors.affiliation: Departamento de Microbiología y Ecología, Universitat de València, Burjassot, Spain.
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Gil
authors.affiliation: Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Pla
authors.affiliation: Departamento de Microbiología y Ecología, Universitat de València, Burjassot, Spain. Electronic address: Daniel.gozalbo@uv.es.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gozalbo
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000254:growth & development* / Q000276:immunology*; D058365:Candidiasis, Invasive / Q000276:immunology*; D004198:Disease Susceptibility; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000382:microbiology*; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D051195:Toll-Like Receptor 2 / Q000172:deficiency / Q000378:metabolism*
chemical_list: C493486:Tlr2 protein, mouse; D051195:Toll-Like Receptor 2
keywords: Candida albicans; Gut colonization; Immunosuppressed mice; TLR2