title: Association between white blood cell count and non-alcoholic fatty liver disease in urban Han Chinese: a prospective cohort study.
abstract: The white blood cell (WBC) count is a simple and convenient marker of inflammation for use in medical practice; however, its association with non-alcoholic fatty liver disease (NAFLD) has not been determined. We examined the relationship between WBC and NAFLD to provide a convenient and useful marker for the prediction of NAFLD.
  
  
  
  A longitudinal cohort participating in a large health check-up programme for the Chinese population was selected and followed up from 2005 to 2011.
  
  
  
  A total of 21 307 male and female participants without NAFLD who underwent health check-ups at least twice between 2005 and 2011 were included in this study. 15 201 participants (7286 men and 7915 women) were eligible for inclusion.
  
  
  
  The baseline distribution of age, WBC, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), serum total protein (TP), albumin (ALB) and globin (GLO) and the prevalence of males, hypertension, hyperglycaemia, smoking and regular exercise were significantly different between the incident NAFLD and non-NAFLD groups (p<0.05). Cox proportional hazards regression analysis was performed to estimate the HRs and 95% CIs of WBC, which predicted the occurrence of NAFLD. Compared with the lowest WBC quartile (Q1), the HRs and 95% CIs of the other WBC quartiles (Q2, Q3 and Q4) for incident NAFLD were 1.090 (0.978 to 1.215), 1.174 (1.055 to 1.305) and 1.152 (1.035 to 1.281), respectively, after adjusting for age, gender, smoking, regular exercise, BMI, hypertension, hyperglycaemia, TC, TG, HDL-C, LDL-C, ALB and GLO.
  
  
  
  Our study clearly showed that WBC count was a significant factor associated with incident NAFLD in Han Chinese.
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan, China.
authors.forename: Shukang
authors.initials: S
authors.lastname: Wang
authors.affiliation: Health Management Center, Shandong Provincial QianFoShan Hospital, Jinan, China.
authors.forename: Chengqi
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Health Management Center, Shandong Provincial QianFoShan Hospital, Jinan, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan, China.
authors.forename: Zhongshang
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan, China.
authors.forename: Yanxun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan, China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Ding
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan, China.
authors.forename: Xiubin
authors.initials: X
authors.lastname: Sun
authors.affiliation: The Second Hospital of Shandong University, Jinan, China.
authors.forename: Hongying
authors.initials: H
authors.lastname: Jia
authors.affiliation: Department of Biostatistics, School of Public Health, Shandong University, Jinan, China.
authors.forename: Fuzhong
authors.initials: F
authors.lastname: Xue
mesh_terms: D000328:Adult; D044466:Asian People; D001794:Blood Pressure; D015992:Body Mass Index; D002681:China; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D007958:Leukocyte Count; D008055:Lipids / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D008055:Lipids
keywords: Chinese adults; Non-alcoholic Fatty Liver Disease (NAFLD); White blood cell (WBC); longitudinal cohort study