title: Region- and Layer-Specific Activation of the Higher Order Auditory Cortex Te2 after Remote Retrieval of Fear or Appetitive Memories.
abstract: The auditory cortex is involved in encoding sounds which have acquired an emotional-motivational charge. However, the neural circuitry engaged by emotional memory processes in the auditory cortex is poorly understood. In this study, we investigated the layers and regions that are recruited in the higher order auditory cortex Te2 by a tone previously paired to either fear or appetitive stimuli in rats. By tracking the protein coded by the immediate early gene zif268, we found that fear memory retrieval engages layers II-III in most regions of Te2. These results were neither due to an enhanced fear state nor to fear-evoked motor responses, as they were absent in animals retrieving an olfactory fear memory. These layers were also activated by appetitive auditory memory retrieval. Strikingly, layer IV was recruited by fear, but not appetitive memories, whereas layer V activity was related to the behavioral responses displayed to the CS. In addition to revealing the layers and regions that are recruited in the Te2 by either fear or appetitive remote memories, our study also shows that the neural circuitry within the Te2 that processes and stores emotional memories varies on the basis of the affective motivational charge of tones.
authors.affiliation: Rita Levi-Montalcini Department of Neuroscience, University of Turin, I-10125 Turin, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Grosso
authors.affiliation: Rita Levi-Montalcini Department of Neuroscience, University of Turin, I-10125 Turin, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Cambiaghi
authors.affiliation: Rita Levi-Montalcini Department of Neuroscience, University of Turin, I-10125 Turin, Italy.
authors.forename: Luisella
authors.initials: L
authors.lastname: Milano
authors.affiliation: Rita Levi-Montalcini Department of Neuroscience, University of Turin, I-10125 Turin, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Renna
authors.affiliation: Rita Levi-Montalcini Department of Neuroscience, University of Turin, I-10125 Turin, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Sacco
authors.affiliation: Rita Levi-Montalcini Department of Neuroscience, University of Turin, I-10125 Turin, Italy.|National Institute of Neuroscience-Turin, I-10125 Turin, Italy.
authors.forename: Benedetto
authors.initials: B
authors.lastname: Sacchetti
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001066:Appetite / Q000502:physiology*; D001303:Auditory Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D001362:Avoidance Learning / Q000502:physiology; D003214:Conditioning, Classical; D051766:Early Growth Response Protein 1 / Q000378:metabolism; D005239:Fear; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D051766:Early Growth Response Protein 1; C486110:Egr1 protein, rat
keywords: auditory cortex; cortical circuits; emotional learning; expression of immediate early genes; long-term memory