title: Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol.
abstract: Borneol is a bicyclic monoterpenoid alcohol commonly used in traditional Chinese and Indian medicine. It is extracted from the essential oil of various medicinal plants. It has antibacterial, analgesic, and anti-inflammatory action proven in studies that used oral and intraperitoneal applications of this monoterpene in mice. The current study was designed to develop a topical gel formulation containing the monoterpene borneol using carbopol as gel base and to evaluate its stability. The prepared formulation was subjected to physical characterization and physical-chemistry assessment. The gel was prepared from carbopol and 5% of borneol. The prepared gel was subjected to pharmacotechnical tests such as its pH, viscosity, conductivity, spreadability, centrifugation, and accelerated stability with freezing-thaw cycle. The borneol was successfully incorporated into the carbopol formulation. Borneol gel (BG5) showed good stability after eight months of its development and after 12 days in the freeze-thaw cycle, not showing statistical difference in pH value, conductivity, and viscosity before and after test. Furthermore, the formulation showed a good spreadability. Therefore, it was concluded that the formulation could be very promising alternative for the topical or transdermal treatment of skin diseases.
authors.affiliation: Center for Studies and Research of Medicinal Plants, Federal University of Vale do São Francisco, 56.304-205 Petrolina, PE, Brazil.
authors.forename: Milla Gabriela Belarmino
authors.initials: MG
authors.lastname: Dantas
authors.affiliation: Center for Studies and Research of Medicinal Plants, Federal University of Vale do São Francisco, 56.304-205 Petrolina, PE, Brazil.
authors.forename: Silvio Alan Gonçalves Bomfim
authors.initials: SA
authors.lastname: Reis
authors.affiliation: Center for Studies and Research of Medicinal Plants, Federal University of Vale do São Francisco, 56.304-205 Petrolina, PE, Brazil.
authors.forename: Camila Mahara Dias
authors.initials: CM
authors.lastname: Damasceno
authors.affiliation: Center for Studies and Research of Medicinal Plants, Federal University of Vale do São Francisco, 56.304-205 Petrolina, PE, Brazil.
authors.forename: Larissa Araújo
authors.initials: LA
authors.lastname: Rolim
authors.affiliation: Federal University of Pernambuco, 50.670-901 Recife, PE, Brazil.
authors.forename: Pedro José
authors.initials: PJ
authors.lastname: Rolim-Neto
authors.affiliation: Federal University of Vale do São Francisco, 56.304-205 Petrolina, PE, Brazil.
authors.forename: Ferdinando Oliveira
authors.initials: FO
authors.lastname: Carvalho
authors.affiliation: Department of Physiology, Federal University of Sergipe, 49.100-000 São Cristóvão, SE, Brazil.
authors.forename: Lucindo José
authors.initials: LJ
authors.lastname: Quintans-Junior
authors.affiliation: Center for Studies and Research of Medicinal Plants, Federal University of Vale do São Francisco, 56.304-205 Petrolina, PE, Brazil.
authors.forename: Jackson Roberto Guedes da Silva
authors.initials: JR
authors.lastname: Almeida
mesh_terms: D000818:Animals; D001892:Camphanes / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D005782:Gels; D006863:Hydrogen-Ion Concentration; D051379:Mice; D039821:Monoterpenes / Q000737:chemistry*; D014783:Viscosity
chemical_list: D001892:Camphanes; D005782:Gels; D039821:Monoterpenes; C022871:isoborneol