title: UGT1A6- and UGT2B7-related valproic acid pharmacogenomics according to age groups and total drug concentration levels.
abstract: The role of UGT1A6 and UGT2B7 polymorphisms and the impact of total drug plasma concentration in valproic acid (VPA) pharmacogenomics.
  
  
  
  A total of 134 Greek patients were recruited (76 adults). Patients were genotyped for UGT1A6 19T>G, 541A>G and 552A>C and UGT2B7 802T>C polymorphisms. Patients' demographic and clinical data were registered. Natural logarithm of concentration-to-dose ratio (CDR) was also calculated as the final outcome.
  
  
  
  No significant genotype-related differences in VPA metabolism were noted among various subgroups. An increased lnCDR ratio was noted in children patients compared with adults suggesting increased metabolic capability in younger ages.
  
  
  
  UGT1A6 and UGT2B7 genotypes were not related to significant changes in VPA metabolism, even after controlling for total drug concentration levels. Younger ages were associated with increased VPA clearance rate.
authors.affiliation: Department of Neurology, University of Ioannina, Ioannina, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Chatzistefanidis
authors.affiliation: Medical Genetics & Assisted Reproduction, University of Ioannina, Ioannina, Greece.
authors.forename: Leandros
authors.initials: L
authors.lastname: Lazaros
authors.affiliation: Medical Genetics & Assisted Reproduction, University of Ioannina, Ioannina, Greece.
authors.forename: Katerina
authors.initials: K
authors.lastname: Giaka
authors.affiliation: Department of Pediatrics, University of Ioannina, Stavros Niarchos Avenue, 45500 Ioannina, Greece.
authors.forename: Iliada
authors.initials: I
authors.lastname: Nakou
authors.affiliation: Department of Pediatrics, University of Ioannina, Stavros Niarchos Avenue, 45500 Ioannina, Greece.
authors.forename: Meropi
authors.initials: M
authors.lastname: Tzoufi
authors.affiliation: Medical Genetics & Assisted Reproduction, University of Ioannina, Ioannina, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Georgiou
authors.affiliation: Department of Neurology, University of Ioannina, Ioannina, Greece.
authors.forename: Athanassios
authors.initials: A
authors.lastname: Kyritsis
authors.affiliation: Department of Neurology, University of Ioannina, Ioannina, Greece.
authors.forename: Sofia
authors.initials: S
authors.lastname: Markoula
mesh_terms: D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D014635:Valproic Acid / Q000378:metabolism*
chemical_list: D014635:Valproic Acid; C110655:UDP-glucuronosyltransferase, UGT1A6; C491474:UGT2B7 protein, human; D014453:Glucuronosyltransferase
keywords: UGT1A6; UGT2B7; epilepsy; metabolism; pharmacoresistance; polymorphisms; valproic acid