title: LncRNAs, lost in translation or licence to regulate?
abstract: Over the last decade, advances in transcriptomics have revealed that the pervasive transcription of eukaryotic genomes produces plethora of long noncoding RNAs (lncRNAs), which are now recognized as major regulators of multiple cellular processes. Although they have been thought to lack any protein-coding potential, recent ribosome-profiling data indicate that lncRNAs can interact with the translation machinery, leading to the production of functional peptides in some cases. In this perspective, we have explored the idea that translation can be part of the fate of cytoplasmic lncRNAs, raising the possibility for them to work as bifunctional RNAs, endowed with dual coding and regulatory functions.
authors.affiliation: ncRNA, Epigenetic and Genome Fluidity, Institut Curie, PSL Research University, CNRS UMR 3244, Université Pierre et Marie Curie, 26 rue d'Ulm, 75248, Paris Cedex 05, France.
authors.forename: Alvaro
authors.initials: A
authors.lastname: de Andres-Pablo
authors.affiliation: ncRNA, Epigenetic and Genome Fluidity, Institut Curie, PSL Research University, CNRS UMR 3244, Université Pierre et Marie Curie, 26 rue d'Ulm, 75248, Paris Cedex 05, France. antonin.morillon@curie.fr.
authors.forename: Antonin
authors.initials: A
authors.lastname: Morillon
authors.affiliation: ncRNA, Epigenetic and Genome Fluidity, Institut Curie, PSL Research University, CNRS UMR 3244, Université Pierre et Marie Curie, 26 rue d'Ulm, 75248, Paris Cedex 05, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Wery
mesh_terms: D000818:Animals; D003593:Cytoplasm; D005786:Gene Expression Regulation; D006801:Humans; D059365:Nonsense Mediated mRNA Decay; D014176:Protein Biosynthesis; D034443:RNA Transport; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D062085:RNA, Long Noncoding
keywords: LncRNA; Non-coding genome; RNA decay; Regulatory RNA; Transcription; Translation