title: Concurrent white and gray matter degeneration of disease-specific networks in early-stage Alzheimer's disease and behavioral variant frontotemporal dementia.
abstract: This study investigates regional coherence between white matter (WM) microstructure and gray matter (GM) volume and perfusion measures in Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) using a correlational approach. WM-GM coherence, compared with controls, was stronger between cingulum WM and frontotemporal GM in AD, and temporoparietal GM in bvFTD. In addition, in AD compared with controls, coherence was stronger between inferior fronto-occipital fasciculus WM microstructure and occipital GM perfusion. In this first study assessing regional WM-GM coherence in AD and bvFTD, we show that WM microstructure and GM volume and perfusion measures are coherent, particularly in regions implicated in AD and bvFTD pathology. This indicates concurrent degeneration in disease-specific networks. Our methodology allows for the detection of incipient abnormalities that go undetected in conventional between-group analyses.
authors.affiliation: Department of Radiology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, the Netherlands.
authors.forename: Rebecca M E
authors.initials: RM
authors.lastname: Steketee
authors.affiliation: Department of Radiology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, the Netherlands.
authors.forename: Rozanna
authors.initials: R
authors.lastname: Meijboom
authors.affiliation: Department of Epidemiology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, the Netherlands; Biomedical Imaging Group Rotterdam, Department of Medical Informatics, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, the Netherlands; Biomedical Imaging Group Rotterdam, Department of Radiology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, the Netherlands.
authors.forename: Marius
authors.initials: M
authors.lastname: de Groot
authors.affiliation: Biomedical Imaging Group Rotterdam, Department of Medical Informatics, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, the Netherlands; Biomedical Imaging Group Rotterdam, Department of Radiology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, the Netherlands.
authors.forename: Esther E
authors.initials: EE
authors.lastname: Bron
authors.affiliation: Biomedical Imaging Group Rotterdam, Department of Medical Informatics, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, the Netherlands; Biomedical Imaging Group Rotterdam, Department of Radiology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, the Netherlands; Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands.
authors.forename: Wiro J
authors.initials: WJ
authors.lastname: Niessen
authors.affiliation: Department of Radiology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, the Netherlands.
authors.forename: Aad
authors.initials: A
authors.lastname: van der Lugt
authors.affiliation: Department of Neurology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, the Netherlands.
authors.forename: John C
authors.initials: JC
authors.lastname: van Swieten
authors.affiliation: Department of Radiology, Erasmus MC-University Medical Centre Rotterdam, Rotterdam, the Netherlands. Electronic address: marion.smits@erasmusmc.nl.
authors.forename: Marion
authors.initials: M
authors.lastname: Smits
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D057180:Frontotemporal Dementia / Q000000981:diagnostic imaging* / Q000473:pathology*; D066128:Gray Matter / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000000981:diagnostic imaging* / Q000473:pathology*; D066127:White Matter / Q000000981:diagnostic imaging* / Q000473:pathology*
keywords: Alzheimer's disease; Arterial spin labeling; Behavioral variant frontotemporal dementia; Diffusion tensor imaging; Structural MRI