title: Thoracic involvement in generalised lymphatic anomaly (or lymphangiomatosis).
abstract: Generalised lymphatic anomaly (GLA), also known as lymphangiomatosis, is a rare disease caused by congenital abnormalities of lymphatic development. It usually presents in childhood but can also be diagnosed in adults. GLA encompasses a wide spectrum of clinical manifestations ranging from single-organ involvement to generalised disease. Given the rarity of the disease, most of the information regarding it comes from case reports. To date, no clinical trials concerning treatment are available. This review focuses on thoracic GLA and summarises possible diagnostic and therapeutic approaches.
authors.affiliation: Unità Operativa di Pneumologia e Terapia Semi-Intensiva Respiratoria, Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe, Multimedica IRCCS, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Luisi
authors.affiliation: Unità Operativa di Pneumologia e Terapia Semi-Intensiva Respiratoria, Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe, Multimedica IRCCS, Milan, Italy sharari@hotmail.it.
authors.forename: Olga
authors.initials: O
authors.lastname: Torre
authors.affiliation: Unità Operativa di Pneumologia e Terapia Semi-Intensiva Respiratoria, Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe, Multimedica IRCCS, Milan, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Harari
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D008171:Lung Diseases / Q000151:congenital* / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D008200:Lymphangiectasis / Q000151:congenital* / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D010166:Palliative Care; D011237:Predictive Value of Tests; D011379:Prognosis; D035583:Rare Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D012307:Risk Factors; D014057:Tomography, X-Ray Computed