title: Evaluation of blood pressure and aortic elasticity of offspring of diabetic Wistar rats who have consumed flaxseed oil during pregnancy and lactation.
abstract: OBJECTIVE
  This study aimed to investigate whether maternal use of flaxseed oil has effects on blood pressure and aorta elastic fibre in female offspring of diabetic mothers.
  
  
  METHODS
  Diabetes was induced into the rats (n = 18) by a high-fat diet and streptozotocin. After diabetes confirmation, rats were mated, and after pregnancy was confirmed, they were allocated into three groups: control group (CG); high-fat group (HFG); and flaxseed oil group (FOG). At weaning, female offspring (n = 6/group) received standard chow diet and were euthanized at 100 days of life. The following blood pressure and the percentage of the aortic elastic fibre were analysed.
  
  
  RESULTS
  HFG showed higher blood pressure, and the use of flaxseed oil avoided this condition in FOG (p < 0.001) and increased the percentage of the aortic elastic fibre (p < 0.022).
  
  
  CONCLUSIONS
  Flaxseed oil reduced the damage caused by maternal hyperglycaemia, promoting normal blood pressure and elasticity of the aorta in female offspring.
authors.affiliation: a Laboratory of Experimental Nutrition (LabNE) , College of Nutrition, Federal Fluminense University (UFF) , Niterói , RJ , Brazil and.
authors.forename: Gabriela Câmara
authors.initials: GC
authors.lastname: Vicente
authors.affiliation: a Laboratory of Experimental Nutrition (LabNE) , College of Nutrition, Federal Fluminense University (UFF) , Niterói , RJ , Brazil and.
authors.forename: André Manoel
authors.initials: AM
authors.lastname: Correia-Santos
authors.affiliation: b Laboratory of Cellular and Extracellular Biomorphology , Federal Fluminense University (UFF) , Niterói , RJ , Brazil.
authors.forename: Maurício Alves
authors.initials: MA
authors.lastname: Chagas
authors.affiliation: a Laboratory of Experimental Nutrition (LabNE) , College of Nutrition, Federal Fluminense University (UFF) , Niterói , RJ , Brazil and.
authors.forename: Gilson Teles
authors.initials: GT
authors.lastname: Boaventura
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001011:Aorta / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D059305:Diet, High-Fat; D004548:Elasticity; D005260:Female; D007774:Lactation / Q000187:drug effects; D008043:Linseed Oil / Q000008:administration & dosage*; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D014664:Vasodilation
chemical_list: D013311:Streptozocin; D008043:Linseed Oil
keywords: Blood pressure; diabetes; flaxseed oil; metabolic programming; rats