title: Fatigue in Parkinson's disease: report from a mutidisciplinary symposium.
abstract: Fatigue is a severe problem for many people living with Parkinson's disease (PD). Best estimates suggest that more than 50% of patients experience this debilitating symptom. Little is known about its etiology or treatment, making the understanding of fatigue a true unmet need. As part of the Parkinson's Disease Foundation Community Choice Research Program, patients, caregivers, and scientists attended a symposium on fatigue on 16 and 17 October 2014. We present a summary of that meeting, reviewing what is known about the diagnosis and treatment of fatigue, its physiology, and what we might learn from multiple sclerosis (MS), depression, and cancer-disorders in which fatigue figures prominently too. We conclude with focused recommendations to enhance our understanding and treatment of this prominent problem in PD.
authors.affiliation: Movement Disorders Program, Butler Hospital, Province, RI, USA; Department of Neurology, Alpert Medical School of Brown University, Providence, RI, USA.
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Friedman
authors.affiliation: Parkinson's Disease Foundation, New York, NY, USA.
authors.forename: James C
authors.initials: JC
authors.lastname: Beck
authors.affiliation: Department of Neurology, University of Michigan Health System, Ann Arbor, MI, USA; Department of Neurosurgery, University of Michigan Health System, Ann Arbor, MI, USA.
authors.forename: Kelvin L
authors.initials: KL
authors.lastname: Chou
authors.affiliation: Parkinson's Disease Foundation, New York, NY, USA.
authors.forename: Gracia
authors.initials: G
authors.lastname: Clark
authors.affiliation: Department of Psychology, Rice University, M.D. Anderson Cancer Center, Houston, TX, USA; Department of Health Disparities, Houston, TX, USA.
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Fagundes
authors.affiliation: Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Goetz
authors.affiliation: Department of Neurology, Sorlandet Hospital, Arendal, Norway.
authors.forename: Karen
authors.initials: K
authors.lastname: Herlofson
authors.affiliation: Department of Neurology, University of Colorado Anschutz Campus, Aurora, CO, USA.
authors.forename: Benzi
authors.initials: B
authors.lastname: Kluger
authors.affiliation: Department of Neurology, Stony Brook University Medical Center, Stony Brook, NY, USA.
authors.forename: Lauren B
authors.initials: LB
authors.lastname: Krupp
authors.affiliation: Toronto Western Hospital, Morton and Gloria Shulman Movement Disorders Clinic and Edmond J Safra Program in Parkinson's Disease, Toronto, ON, Canada.
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Lang
authors.affiliation: University of North Dakota School of Medicine and Health Services, Sanford Health, Grand Forks, ND, USA.
authors.forename: Jao-Shin
authors.initials: JS
authors.lastname: Lou
authors.affiliation: Department of Psychiatry, Baylor College of Medicine, Mental Health Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA; Department of Neurology, Baylor College of Medicine, Mental Health Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Marsh
authors.affiliation: Parkinson's Disease Foundation, New York, NY, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Newbould
authors.affiliation: Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Weintraub