title: Genetic Diversity and Population Structure of Haemonchus contortus.
abstract: Haemonchus contortus is one of the most successful and problematic livestock parasites worldwide. From its apparent evolutionary origins in sub-Saharan Africa, it is now found in small ruminants in almost all regions of the globe, and can infect a range of different domestic and wildlife artiodactyl hosts. It has a remarkably high propensity to develop resistance to anthelmintic drugs, making control increasingly difficult. The success of this parasite is, at least in part, due to its extremely high levels of genetic diversity that, in turn, provide a high adaptive capacity. Understanding this genetic diversity is important for many areas of research including anthelmintic resistance, epidemiology, control, drug/vaccine development and molecular diagnostics. In this article, we review the current knowledge of H. contortus genetic diversity and population structure for both field isolates and laboratory strains. We highlight the practical relevance of this knowledge with a particular emphasis on anthelmintic resistance research.
authors.affiliation: University of Calgary, Calgary, AB, Canada.
authors.forename: J S
authors.initials: JS
authors.lastname: Gilleard
authors.affiliation: University of Calgary, Calgary, AB, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Redman
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D004351:Drug Resistance; D014644:Genetic Variation; D005828:Genetics, Population; D006188:Haemonchiasis / Q000453:epidemiology / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D006189:Haemonchus / Q000187:drug effects / Q000235:genetics*; D058751:Livestock; D012418:Ruminants / Q000469:parasitology
chemical_list: D000871:Anthelmintics
keywords: AFLP; Anthelmintic resistance; Genetic variation; Haemonchus contortus; Population genetics; SNP