title: Drug combination therapy increases successful drug repositioning.
abstract: Repositioning of approved drugs has recently gained new momentum for rapid identification and development of new therapeutics for diseases that lack effective drug treatment. Reported repurposing screens have increased dramatically in number in the past five years. However, many newly identified compounds have low potency; this limits their immediate clinical applications because the known, tolerated plasma drug concentrations are lower than the required therapeutic drug concentrations. Drug combinations of two or more compounds with different mechanisms of action are an alternative approach to increase the success rate of drug repositioning.
authors.affiliation: National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, MSC:3375, Bethesda, MD 20892, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, MSC:3375, Bethesda, MD 20892, USA.
authors.forename: Philip E
authors.initials: PE
authors.lastname: Sanderson
authors.affiliation: National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, MSC:3375, Bethesda, MD 20892, USA. Electronic address: wzheng@mail.nih.gov.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000818:Animals; D004338:Drug Combinations; D004347:Drug Interactions; D058492:Drug Repositioning; D004359:Drug Therapy, Combination; D006801:Humans; D064798:Polypharmacology
chemical_list: D004338:Drug Combinations