title: Altered resting-state functional activity in posttraumatic stress disorder: A quantitative meta-analysis.
abstract: Many functional neuroimaging studies have reported differential patterns of spontaneous brain activity in posttraumatic stress disorder (PTSD), but the findings are inconsistent and have not so far been quantitatively reviewed. The present study set out to determine consistent, specific regional brain activity alterations in PTSD, using the Effect Size Signed Differential Mapping technique to conduct a quantitative meta-analysis of resting-state functional neuroimaging studies of PTSD that used either a non-trauma (NTC) or a trauma-exposed (TEC) comparison control group. Fifteen functional neuroimaging studies were included, comparing 286 PTSDs, 203 TECs and 155 NTCs. Compared with NTC, PTSD patients showed hyperactivity in the right anterior insula and bilateral cerebellum, and hypoactivity in the dorsal medial prefrontal cortex (mPFC); compared with TEC, PTSD showed hyperactivity in the ventral mPFC. The pooled meta-analysis showed hypoactivity in the posterior insula, superior temporal, and Heschl's gyrus in PTSD. Additionally, subgroup meta-analysis (non-medicated subjects vs. NTC) identified abnormal activation in the prefrontal-limbic system. In meta-regression analyses, mean illness duration was positively associated with activity in the right cerebellum (PTSD vs. NTC), and illness severity was negatively associated with activity in the right lingual gyrus (PTSD vs. TEC).
authors.affiliation: Department of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu, P. R. China.|Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, P. R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, P. R. China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu, P. R. China.|Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, P. R. China.
authors.forename: Junran
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Neuroimaging Center, University of Maryland, College Park, Maryland, USA.
authors.forename: Wang
authors.initials: W
authors.lastname: Zhan
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.affiliation: Department of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu, P. R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Huang
authors.affiliation: Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, P. R. China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Magnetic Resonance and Image Analysis Research Centre (MARIARC) and Institute of Ageing and Chronic Disease, University of Liverpool, United Kingdom.
authors.forename: Graham J
authors.initials: GJ
authors.lastname: Kemp
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, P. R. China.|Department of Psychology, School of Public Administration, Sichuan University, Chengdu, P. R. China.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D005260:Female; D006801:Humans; D008032:Limbic System / Q000503:physiopathology; D008297:Male; D017397:Prefrontal Cortex / Q000503:physiopathology; D012720:Severity of Illness Index; D013313:Stress Disorders, Post-Traumatic / Q000000981:diagnostic imaging* / Q000503:physiopathology; D013997:Time Factors