title: Aspirin for the Prevention of Preeclampsia and Intrauterine Growth Restriction.
abstract: Low-dose aspirin (LDA) has been used for several years for the prevention of preeclampsia (PE). LDA started in early pregnancy is associated with improvement of placental implantation. The best evidence suggest that LDA can prevent more than half of PE cases in high-risk women when started before 16 weeks of gestation. Moreover, LDA started in early pregnancy reduces the risk of other placenta-mediated complications such as intrauterine growth restriction (IUGR) and perinatal death. The efficacy of LDA has been demonstrated in women with abnormal first-trimester uterine artery Doppler or with prior history of chronic hypertension or preeclampsia.
authors.affiliation: Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, 2705 Boulevard Laurier, Quebec G1V 4G2, Canada.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Roberge
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of South Florida Morsani College of Medicine, 2 Tampa General Circle, 6th Floor, Tampa, FL 33606, USA.
authors.forename: Anthony O
authors.initials: AO
authors.lastname: Odibo
authors.affiliation: Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, 2705 Boulevard Laurier, Quebec G1V 4G2, Canada; Department of Obstetrics and Gynecology, Faculty of Medicine, Université Laval, 2705 Boulevard Laurier, Québec City, Quebec G1V 4G2, Canada. Electronic address: emmanuel.bujold@crchudequebec.ulaval.ca.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bujold
mesh_terms: D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005317:Fetal Growth Retardation / Q000517:prevention & control*; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy
chemical_list: D006493:Heparin; D001241:Aspirin
keywords: Aspirin; Intrauterine growth restriction; Placenta; Preeclampsia; Pregnancy