title: Computational insights into the origin of decrease/increase in potency of N-CDPCB analogues toward FTO.
authors.affiliation: a Department of Pathophysiology , Basic Medical College of Zhengzhou University , Zhengzhou 450001 , People's Republic of China.|b Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy , East China University of Science & Technology , Shanghai 200237 , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: c College of Chemistry and Molecular Engineering , Zhengzhou University , Zhengzhou 450001 , People's Republic of China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Yang
authors.affiliation: c College of Chemistry and Molecular Engineering , Zhengzhou University , Zhengzhou 450001 , People's Republic of China.
authors.forename: Chuanjun
authors.initials: C
authors.lastname: Song
authors.affiliation: a Department of Pathophysiology , Basic Medical College of Zhengzhou University , Zhengzhou 450001 , People's Republic of China.
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang
mesh_terms: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D000627:Aminophenols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000813:Anilides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D019295:Computational Biology; D018360:Crystallography, X-Ray; D006801:Humans; D011487:Protein Conformation / Q000187:drug effects
chemical_list: D000627:Aminophenols; D000813:Anilides; C000603797:N-(5-chloro-2,4-dihydroxyphenyl)-1-phenylcyclobutanecarboxamide; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human