title: Short-term cardiovascular and autonomic effects of inhaled salbutamol.
abstract: Asthma independently increases the risk of developing cardiovascular disease. As inhaled β-agonists have systemic cardiovascular effects, and elevations in arterial stiffness and sympathetic nerve activity are associated with increased cardiovascular morbidity/mortality, this study examines the effect of salbutamol use on pulse wave velocity (PWV) and muscle sympathetic nervous activity (MSNA). Healthy men and women (26.2±1.5years) were recruited for: Day 1: 4 inhalations of placebo followed by 4 inhalations of salbutamol (4×100μg); Day 2: placebo only; Day 3: carotid-femoral PWV measurements before/after placebo/salbutamol. Heart rate (HR), mean arterial pressure (MAP), and carotid-radial PWV were obtained on Day 1 and 2. MSNA was obtained on Day 1. Salbutamol increased HR and total MSNA (Baseline1: 2.8±2.8au; Placebo: 2.4±2.1au; Baseline2: 2.7±3.0au; Salbutamol: 3.3±2.9au; p=0.05), with no changes in MAP or PWV. There were no effects of placebo on HR, MSNA, or PWV. Acute salbutamol use increases sympathetic activity suggesting that salbutamol could contribute to cardiovascular morbidity/mortality in individuals using inhaled β-agonists.
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, T6G 2J3, Canada; School of Kinesiology and Health Sciences, York University, Toronto, M3J 1P3, Canada. Electronic address: edgell@yorku.ca.
authors.forename: Heather
authors.initials: H
authors.lastname: Edgell
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, T6G 2J3, Canada.
authors.forename: Linn E
authors.initials: LE
authors.lastname: Moore
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, T6G 2J3, Canada.
authors.forename: Carol
authors.initials: C
authors.lastname: Chung
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, T6G 2J3, Canada.
authors.forename: Bradley W
authors.initials: BW
authors.lastname: Byers
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, T6G 2J3, Canada; G.F. MacDonald Centre for Lung Health, Covenant Health, Edmonton, T5K 0L4, Canada.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Stickland
mesh_terms: D000280:Administration, Inhalation; D058666:Adrenergic beta-2 Receptor Agonists / Q000008:administration & dosage* / Q000009:adverse effects; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage* / Q000009:adverse effects; D062186:Arterial Pressure / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000453:epidemiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D063177:Pulse Wave Analysis; D012306:Risk; D013564:Sympathetic Nervous System / Q000187:drug effects*; D059289:Vascular Stiffness / Q000187:drug effects*; D055815:Young Adult
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D000420:Albuterol
keywords: Beta-agonist; Cardiovagal baroreceptor sensitivity; Heart rate variability; Muscle sympathetic nerve activity; Pulse wave velocity