title: PPAR Modulating Polyketides from a Chinese Plakortis simplex and Clues on the Origin of Their Chemodiversity.
abstract: Fifteen polyketides, including the first hydroxylated plakortone (12) and plakdiepoxide (15), the first polyketide to embed a vicinal diepoxide, have been isolated from the Chinese sponge Plakortis simplex. The structures of the new metabolites were elucidated by analysis of spectroscopic data, Mosher's derivatization, and DFT computational calculations. The reactivity of the major endoperoxide of this sponge was investigated, suggesting that furan, furanylidene, and plakilactone derivatives, well-known classes of natural products, could actually be chemical degradation products. Plakdiepoxide is a potent and selective modulator of peroxisome proliferator-activated receptor (PPAR)-γ, while the diunsaturated C12 fatty acid monotriajaponide (13) activates both PPAR-α and PPAR-γ, a dual activity of potential great importance for the treatment of metabolic disorders.
authors.affiliation: Department of Pharmacy, University of Naples Federico II , Via D. Montesano 49, 80131 Naples, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Chianese
authors.affiliation: Research Center for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200127, People's Republic of China.
authors.forename: Hao-Bing
authors.initials: HB
authors.lastname: Yu
authors.affiliation: Research Center for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200127, People's Republic of China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Pharmacy, University of Naples Federico II , Via D. Montesano 49, 80131 Naples, Italy.
authors.forename: Carmina
authors.initials: C
authors.lastname: Sirignano
authors.affiliation: Department of Pharmacy, University of Naples Federico II , Via D. Montesano 49, 80131 Naples, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Luciano
authors.affiliation: Research Center for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200127, People's Republic of China.
authors.forename: Bing-Nan
authors.initials: BN
authors.lastname: Han
authors.affiliation: National Center for Natural Products Research, School of Pharmacy, University of Mississippi , University, Mississippi 38677, United States.
authors.forename: Shabana
authors.initials: S
authors.lastname: Khan
authors.affiliation: Research Center for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200127, People's Republic of China.
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Lin
authors.affiliation: Department of Pharmacy, University of Naples Federico II , Via D. Montesano 49, 80131 Naples, Italy.
authors.forename: Orazio
authors.initials: O
authors.lastname: Taglialatela-Scafati