title: [The comeback of mitochondria in Drosophila apoptosis].
abstract: The role of the mitochondrion in mammalian cell apoptosis has been established since the mid-1990s. However, the importance of this organelle in non-mammalian apoptosis has long been regarded as minor, notably because of the absence of a crucial role for cytochrome c in caspase activation. Recent results indicate that the control of caspase activation and apoptosis in Drosophila cell death occurs at the mitochondrial level. Numerous proteins that appear key for Drosophila apoptosis regulation constitutively or transiently bind to mitochondria. They participate in the cell death process at different levels such as degradation of an IAP caspase inhibitor, production of mitochondrial reactive oxygen species or stimulation of the mitochondrial fission machinery. The aim of this review is to take stock of these events that might have their counterpart in humans.
authors.affiliation: Laboratoire de génétique et biologie cellulaire, université de Versailles Saint-Quentin-en-Yvelines, université Paris-Saclay, 2, avenue de la Source de la Bièvre, 78180 Montigny-le-Bretonneux, France - Laboratoire de génétique moléculaire et physiologique, École pratique des hautes études, PSL research university, 78180 Montigny-le-Bretonneux, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Clavier
authors.affiliation: Laboratoire de génétique et biologie cellulaire, université de Versailles Saint-Quentin-en-Yvelines, université Paris-Saclay, 2, avenue de la Source de la Bièvre, 78180 Montigny-le-Bretonneux, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Rincheval-Arnold
authors.affiliation: Laboratoire de génétique et biologie cellulaire, université de Versailles Saint-Quentin-en-Yvelines, université Paris-Saclay, 2, avenue de la Source de la Bièvre, 78180 Montigny-le-Bretonneux, France - Laboratoire de génétique moléculaire et physiologique, École pratique des hautes études, PSL research university, 78180 Montigny-le-Bretonneux, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Mignotte
authors.affiliation: Laboratoire de génétique et biologie cellulaire, université de Versailles Saint-Quentin-en-Yvelines, université Paris-Saclay, 2, avenue de la Source de la Bièvre, 78180 Montigny-le-Bretonneux, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Guénal
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000502:physiology; D017173:Caenorhabditis elegans; D045304:Cytochromes c / Q000502:physiology; D004330:Drosophila / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D063154:Mitochondrial Dynamics / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology
chemical_list: D051017:Apoptosis Regulatory Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D045304:Cytochromes c