title: Metalloproteinases: a Functional Pathway for Myeloid Cells.
abstract: Myeloid cells have diverse roles in regulating immunity, inflammation, and extracellular matrix turnover. To accomplish these tasks, myeloid cells carry an arsenal of metalloproteinases, which include the matrix metalloproteinases and the adamalysins. These enzymes have diverse substrate repertoires, and are thus involved in mediating proteolytic cascades, cell migration, and cell signaling. Dysregulation of metalloproteinases contributes to pathogenic processes, including inflammation, fibrosis, and cancer. Metalloproteinases also have important nonproteolytic functions in controlling cytoskeletal dynamics during macrophage fusion and enhancing transcription to promote antiviral immunity. This review highlights the diverse contributions of metalloproteinases to myeloid cell functions.
authors.affiliation: Department of Anatomy, University of California, San Francisco, CA 94143.|Department of Medicine, University of California, San Francisco, CA 94143.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Chou
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, CA 94143.
authors.forename: Matilda F
authors.initials: MF
authors.lastname: Chan
authors.affiliation: Department of Anatomy, University of California, San Francisco, CA 94143.
authors.forename: Zena
authors.initials: Z
authors.lastname: Werb
mesh_terms: D000818:Animals; D006801:Humans; D045726:Metalloproteases / Q000378:metabolism*; D022423:Myeloid Cells / Q000201:enzymology*
chemical_list: D045726:Metalloproteases