title: [The current situation of aggravated intoxication with "kiken" drugs (law-evading drugs)].
abstract: The intoxication caused by "kiken" drugs (law-evading drugs), such as synthetic cannabinoids, cathinones, and methoxetamine, has recently increased in Japan. We retrospectively examined the characteristics of patients poisoned with the "kiken" drugs. We included patients who presented at the emergency department at the Tokyo Metropolitan Bokutoh Hospital from January 2011 to December 2014. Eighteen patients admitted between January 2011 and December 2013 were included in the early period group and 10 patients admitted between January and December 2014 were categorized into the late period group. The number of the patients transported to our emergency department between 2011 and 2014 increased annually. Patients were mainly admitted between May and October 2014; no patients were admitted after November 2014. The patients' age, history of previous mental disease, habitual use, Triage DOA results, serum creatinine values on admission, and respiratory management differed significantly between the groups. However, the median serum creatinine values of both groups on admission were within the normal level. Patients poisoned with the "kiken" drugs showed more severe symptoms, higher rate of habitual use, and higher average age. The annual increase in the number of the patients observed thus far is expected to decrease in the future. Maintenance of the law and expansion of medical institutions that treat patients addicted to the "kiken" drugs are warranted.
authors.forename: Akiko
authors.initials: A
authors.lastname: Akashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kashiura
authors.forename: Manabu
authors.initials: M
authors.lastname: Mikami
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hamabe
mesh_terms: D000328:Adult; D000367:Age Factors; D000470:Alkaloids / Q000506:poisoning*; D002186:Cannabinoids / Q000506:poisoning*; D003404:Creatinine / Q000097:blood; D003512:Cyclohexanones / Q000506:poisoning*; D003514:Cyclohexylamines / Q000506:poisoning*; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D013287:Illicit Drugs / Q000506:poisoning*; D008297:Male; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000453:epidemiology* / Q000209:etiology*; D013997:Time Factors; D014041:Tokyo / Q000453:epidemiology; D014218:Triage; D055815:Young Adult
chemical_list: D000470:Alkaloids; D002186:Cannabinoids; D003512:Cyclohexanones; D003514:Cyclohexylamines; D013287:Illicit Drugs; C023665:cathinone; D003404:Creatinine; C569113:2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone