title: Serum-based protein profiles of Alzheimer's disease and mild cognitive impairment in elderly Hispanics.
abstract: To describe the biomarker profiles in elderly Panamanians diagnosed with Alzheimer's disease (AD), mild cognitive impairment (MCI) or no impairment using serum-based biomarkers.
  
  
  
  Twenty-four proteins were analyzed using an electrochemiluminescence-based multiplex biomarker assay platform. A biomarker profile was generated using random forest analyses.
  
  
  
  Two proteins differed among groups: IL-18 and T-lymphocyte-secreted protein I-309. The AD profile was highly accurate and independent of age, gender, education and Apolipoprotein E ε4 status. AD and MCI profiles had substantial overlap among the top markers, suggesting common functions in AD and MCI but differences in their relative importance.
  
  
  
  Our results underscore the potential influence of genetic and environmental differences within Hispanic populations on the proteomic profile of AD.
authors.affiliation: Centro de Neurociencias y Unidad de Investigación Clínica, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber 219, Clayton, Apartado Postal 0843-01103, República de Panamá|Department of Biotechnology, Acharya Nagarjuna University, Guntur, India.
authors.forename: Alcibiades E
authors.initials: AE
authors.lastname: Villarreal
authors.affiliation: Institute for Healthy Aging, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
authors.forename: Sid E
authors.initials: SE
authors.lastname: O'Bryant
authors.affiliation: Department of Psychology, University of North Texas, 1155 Union Circle, Denton, TX 76203, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Edwards
authors.affiliation: Centro de Neurociencias y Unidad de Investigación Clínica, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber 219, Clayton, Apartado Postal 0843-01103, República de Panamá
authors.forename: Shantal
authors.initials: S
authors.lastname: Grajales
authors.affiliation: Centro de Neurociencias y Unidad de Investigación Clínica, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber 219, Clayton, Apartado Postal 0843-01103, República de Panamá
authors.forename: Gabrielle B
authors.initials: GB
authors.lastname: Britton
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D000544:Alzheimer Disease / Q000097:blood*; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000097:blood*; D015331:Cohort Studies; D016207:Cytokines / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D016207:Cytokines
keywords: Hispanic; Latin America; aging; blood-based biomarkers; cognition; dementia