title: The Clinical Characteristics of Metanephric Adenoma: A Case Report and Literature Review.
abstract: We describe the clinical presentation, diagnosis, treatment, and follow-up data of a 39-year-old woman with asymptomatic right kidney tumor, which was later histopathologically diagnosed as metanephric adenoma (MA). Macroscopically, the tumor had integrity tegument with homogeneous and gray cutting surface. Microscopically, the tumor cells were formed in adenoid or papillary pattern and contained psammoma bodies, without distinctive atypia. Immunohistochemistry results showed they were negative for creatine kinase 7, epithelial membrane antigen, and renal cell carcinoma, and positive for AE1/AE3, vimentin, and Wilms Tumor 1. Pathological diagnosis was MA. The 48 months' follow-up information was available without recurrence.According to this case and literature review, we figured that it is difficult to make a definite diagnosis of MA only by image examination. Nephron-sparing surgery is eligible to treat MA. Long-term active surveillance is necessary because of the uncertainty of the biological behavior and cellular origin of MA.
authors.affiliation: From the Department of Urology (HF, H-ZL, Y-SZ); Department of General Surgery (Q-QS); and Department of Pathology (YX), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Fan
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Shao
authors.forename: Han-Zhong
authors.initials: HZ
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Xiao
authors.forename: Yu-Shi
authors.initials: YS
authors.lastname: Zhang
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D001457:Anion Exchange Protein 1, Erythrocyte / Q000378:metabolism; D017920:Antiporters / Q000378:metabolism; D014408:Biomarkers, Tumor; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D018396:Mucin-1 / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
chemical_list: D001457:Anion Exchange Protein 1, Erythrocyte; D017920:Antiporters; D014408:Biomarkers, Tumor; D018396:Mucin-1; C454201:SLC4A1 protein, human; C489237:SLC4A3 protein, human; D014746:Vimentin