title: Study of optical clearing in polarization measurements by Monte Carlo simulations with anisotropic tissue-mimicking models.
abstract: We conducted Monte Carlo simulations based on anisotropic sclera-mimicking models to examine the polarization features in Mueller matrix polar decomposition (MMPD) parameters during the refractive index matching process, which is one of the major mechanisms of optical clearing. In a preliminary attempt, by changing the parameters of the models, wavelengths, and detection geometries, we demonstrate how the depolarization coefficient and retardance vary during the refractive index matching process and explain the polarization features using the average value and standard deviation of scattering numbers of the detected photons. We also study the depth-resolved polarization features during the gradual progression of the refractive index matching process. The results above indicate that the refractive index matching process increases the depth of polarization measurements and may lead to higher contrast between tissues of different anisotropies in deeper layers. MMPD-derived polarization parameters can characterize the refractive index matching process qualitatively.
authors.affiliation: Tsinghua University, Graduate School at Shenzhen, Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, 2279 Lishui Road, Shenzhen 518055, ChinabTsinghua University, Department of Physics, 30 Shuangqi.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Chen
authors.affiliation: Tsinghua University, Graduate School at Shenzhen, Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, 2279 Lishui Road, Shenzhen 518055, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zeng
authors.affiliation: Tsinghua University, Graduate School at Shenzhen, Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, 2279 Lishui Road, Shenzhen 518055, ChinabTsinghua University, Department of Physics, 30 Shuangqi.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Tsinghua University, Department of Physics, 30 Shuangqing Road, Beijing 100084, China.
authors.forename: Honghui
authors.initials: H
authors.lastname: He
authors.affiliation: Saratov State University, Research-Educational Institute of Optics and Biophotonics, 83 Astrakhanskaya Street, Saratov 410012, RussiadTomsk State University, Laboratory of Biophotonics, 36 Lenin Avenue, Tomsk 634050, RussiaeInstitute of Precision Mechanic.
authors.forename: Valery V
authors.initials: VV
authors.lastname: Tuchin
authors.affiliation: Tsinghua University, Graduate School at Shenzhen, Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, 2279 Lishui Road, Shenzhen 518055, ChinabTsinghua University, Department of Physics, 30 Shuangqi.
authors.forename: Hui
authors.initials: H
authors.lastname: Ma
mesh_terms: D016880:Anisotropy; D003198:Computer Simulation; D003287:Contrast Media / Q000737:chemistry*; D006801:Humans; D008954:Models, Biological; D009010:Monte Carlo Method; D061848:Optical Imaging / Q000379:methods*; D012031:Refractometry; D012542:Scattering, Radiation; D012590:Sclera / Q000737:chemistry / Q000502:physiology
chemical_list: D003287:Contrast Media