title: Anti-Inflammatory Effects of Modified Adenoviral Vectors for Gene Therapy: A View through Animal Models Tested.
abstract: The central dogma of gene therapy relies on the application of novel therapeutic genes to treat or prevent diseases. The main types of vectors used for gene transfer are adenovirus, retrovirus, lentivirus, liposome, and adeno-associated virus vectors. Gene therapy has emerged as a promising alternative for the treatment of inflammatory diseases. The main targets are cytokines, co-stimulatory molecules, and different types of cells from hematological and mesenchymal sources. In this review, we focus on molecules with anti-inflammatory effects used for in vivo gene therapy mediated by adenoviral gene transfer in the treatment of immune-mediated inflammatory diseases, with particular emphasis on autoinflammatory and autoimmune diseases.
authors.affiliation: a Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud de la Universidad Autonoma de Zacatecas , Zacatecas , Mexico.|b Centro de Innovacion Tecnologica e Industrial, Unidad Academica de Ingenieria Electrica , Universidad Autonoma de Zacatecas , Zacatecas , Mexico.
authors.forename: M E
authors.initials: ME
authors.lastname: Castañeda-Lopez
authors.affiliation: a Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud de la Universidad Autonoma de Zacatecas , Zacatecas , Mexico.|b Centro de Innovacion Tecnologica e Industrial, Unidad Academica de Ingenieria Electrica , Universidad Autonoma de Zacatecas , Zacatecas , Mexico.
authors.forename: I
authors.initials: I
authors.lastname: Garza-Veloz
authors.affiliation: c CONACyT Research Fellow, Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud , Universidad Autonoma de Zacatecas , Mexico.
authors.forename: Y
authors.initials: Y
authors.lastname: Lopez-Hernandez
authors.affiliation: d Laboratory of Cell and Molecular Biology, Unidad Academica de Ciencias Quimicas de la Universidad Autonoma de Zacatecas , Zacatecas , Mexico .
authors.forename: O Y
authors.initials: OY
authors.lastname: Barbosa-Cisneros
authors.affiliation: a Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud de la Universidad Autonoma de Zacatecas , Zacatecas , Mexico.|b Centro de Innovacion Tecnologica e Industrial, Unidad Academica de Ingenieria Electrica , Universidad Autonoma de Zacatecas , Zacatecas , Mexico.
authors.forename: M L
authors.initials: ML
authors.lastname: Martinez-Fierro
mesh_terms: D000256:Adenoviridae / Q000276:immunology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D001688:Biological Products / Q000627:therapeutic use; D004195:Disease Models, Animal; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D007249:Inflammation / Q000276:immunology / Q000628:therapy*; D051379:Mice; D011817:Rabbits; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D001688:Biological Products
keywords: Adenoviruses; cytokine; gene therapy; in vivo model; inflammatory disease