title: Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization.
abstract: Indole is a potential lead for drug design which has been found in numerous pharmaceutically important compounds due to its medicinal properties, such as anti-tumor, anti-bacterial, anti-virus and anti-inflammatory. In the last decade, interfering with microtubule polymerization, a potential orientation to cause cell cycle arrest and apoptosis has become a promising method for cancer therapy. Thus, indole-based agents capable to modulate the microtubule assembly have gained considerable interest among scientists. This review describes the synthesis, bioactivities and SARs of indole-based agents targeting tubulin polymerization during the past decade.
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Sang
authors.affiliation: Nanjing Institute for the Comprehensive Utilization of Wild Plant, Nanjing 210042, People's Republic of China.
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Zhang
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Lv
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210046, People's Republic of China.
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Zhu
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D058105:Polymerization; D014404:Tubulin / Q000737:chemistry*
chemical_list: D007211:Indoles; D014404:Tubulin