title: Edge-to-Edge Technique to Minimize Ovelapping of Multiple Bioresorbable Scaffolds Plus Drug Eluting Stents in Revascularization of Long Diffuse Left Anterior Descending Coronary Artery Disease.
abstract: BACKGROUND
  Implantation of Drug Eluting Stents (DES) plus bioresorbable scaffolds (BVS) in very long diffuse left anterior descending coronary artery (LAD) disease may be problematic because of multiple devices overlapping. We sought to assess the short and mid-tern outcomes of combined implantation of DES and BVS using a novel "edge-to-edge" technique in patients with diffuse LAD disease.
  
  
  METHODS
  Patients with long diffuse LAD disease were enrolled in a prospective registry from 1st August 2014 to 1st August 2015 and treated with IVUS-aided percutaneous coronary intervention using a DES plus a single or multiple BVS using a novel "edge-to-edge" technique. Clinical follow up and invasive follow up driven by clinical justification was performed.
  
  
  RESULTS
  Twenty-three patients (5 females, mean age 59.1± 9.1 years) were enrolled. Mean length of LAD disease was 73.1 ± 20.6 mm. Mean number of DES and BVS implanted was 1.2 ± 0.4 and 1.7 ± 1.3, respectively. At a mean follow-up of 11.3 ± 3.8 months, no stent thrombosis or MACE were observed. Angiographic and IVUS follow-up at a mean of 6.6 ± 0.7 months showed no significant angiographic restenosis and no appreciable stent gaps.
  
  
  CONCLUSIONS
  In revascularization of long diffuse disease of the LAD, the edge-to-edge implantation technique appears to be feasible resulting in no restenosis or thrombosis on the short-term follow-up. (J Interven Cardiol 2016;29:275-284).
authors.affiliation: Cardiovascular Diagnosis and Endoluminal Interventions Unit, Rovigo General Hospital, Rovigo, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Rigatelli
authors.affiliation: Cardiovascular Diagnosis and Endoluminal Interventions Unit, Rovigo General Hospital, Rovigo, Italy.
authors.forename: Fabio Dell'
authors.initials: FD
authors.lastname: Avvocata
authors.affiliation: Emodinamica Aziendale, ULS 12 Veneziana, Mestre-Venezia, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Ronco
authors.affiliation: Cardiovascular Diagnosis and Endoluminal Interventions Unit, Rovigo General Hospital, Rovigo, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Giordan
authors.affiliation: Cardiovascular Diagnosis and Endoluminal Interventions Unit, Rovigo General Hospital, Rovigo, Italy.
authors.forename: Loris
authors.initials: L
authors.lastname: Roncon
authors.affiliation: Emodinamica Aziendale, ULS 12 Veneziana, Mestre-Venezia, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Caprioglio
authors.affiliation: Emodinamica Aziendale, ULS 12 Veneziana, Mestre-Venezia, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Grassi
authors.affiliation: Cardiac Surgery Institute, Verona University School of Medicine, Verona, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Faggian
authors.affiliation: Cardiovascular Diagnosis and Endoluminal Interventions Unit, Rovigo General Hospital, Rovigo, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Cardaioli
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000601:surgery*; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods*; D011446:Prospective Studies; D012042:Registries; D016896:Treatment Outcome