title: Intracranial Hemorrhage Following Intrathecal Methotrexate Therapy for Acute Lymphoblastic Leukaemia.
abstract: BACKGROUND
  Acute toxic leukoencephalopathy following intrathecal methotrexate administration is well documented but intracranial haemorrhage is extremely rare.
  
  
  METHODS
  A 2-year-6 months old girl with acute lymphoblastic leukemia developed sudden onset neurological deterioration following intrathecal methotrexate.
  
  
  METHODS
  Computed tomography scan of brain demonstrated intraventricular and subarachnoid hemorrhage.
  
  
  RESULTS
  Child improved gradually on conservative management. Follow-up neuroimaging showed resolution of hemorrhage.
  
  
  CONCLUSIONS
  Intracranial haemorrhage is a rare but serious complication of intrathecal methotrexate.
authors.affiliation: Departments of Pediatric Medicine and *Haematology, NRS Medical College and Hospital, Kolkata, West Bengal, India. Correspondence to: Dr Radheshyam Purkait, Department of Pediatric Medicine, NRS Medical College and Hospital, Kolkata 700 014, West Bengal, India. radheshyampurkait@gmail.com.
authors.forename: Radheshyam
authors.initials: R
authors.lastname: Purkait
authors.forename: Tuphan Kanti
authors.initials: TK
authors.lastname: Dolai
authors.forename: Chinmoy
authors.initials: C
authors.lastname: Lath
authors.forename: Biswajit
authors.initials: B
authors.lastname: Das
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007278:Injections, Spinal / Q000009:adverse effects*; D020300:Intracranial Hemorrhages / Q000209:etiology*; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D008727:Methotrexate