title: Rapid detection of blaOXA in carbapenem-susceptible Acinetobacter radioresistens bacteremia leading to unnecessary antimicrobial administration.
abstract: Rapid molecular techniques to identify resistant pathogens are revolutionizing antibiotic stewardship; however, it is important to recognize the limitations of these techniques. Herein we describe two cases of bacteremia that were both initially identified by genotypic testing as carbapenem-resistant Acinetobacter spp. and subsequently identified phenotypically as carbapenem-susceptible A. radioresistens. The genotypic results prompted unnecessary broad-spectrum antibiotic use and infection control concerns.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Oregon Health and Science University, Portland, OR. Electronic address: bradya@ohsu.edu.
authors.forename: Adam C
authors.initials: AC
authors.lastname: Brady
authors.affiliation: Department of Pharmacy, Oregon Health and Science University, Portland, OR.
authors.forename: James S
authors.initials: JS
authors.lastname: Lewis
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Oregon Health and Science University, Portland, OR; VA Portland Health Care System, Portland, OR.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Pfeiffer
mesh_terms: D000150:Acinetobacter / Q000187:drug effects / Q000201:enzymology*; D000151:Acinetobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D001618:beta-Lactamases / Q000032:analysis* / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases
keywords: Acinetobacter; Bacteremia; Carbapenemase; Molecular diagnostics; Rapid diagnostics