title: Topical Anti-Inflammatory and Analgesic Effects of Multiple Applications of S(+)-Flurbiprofen Plaster (SFPP) in a Rat Adjuvant-Induced Arthritis Model.
abstract: Preclinical Research The aim of this study was to evaluate the efficacy of multiple applications of S(+)-flurbiprofen plaster (SFPP), a novel Nonsteroidal anti-inflammatory drug (NSAID) patch, for the alleviation of inflammatory pain and edema in rat adjuvant-induced arthritis (AIA) model as compared to other NSAID patches. The AIA model was induced by the injection of Mycobacterium butyricum and rats were treated with a patch (1.0 cm × 0.88 cm) containing each NSAID (SFP, ketoprofen, loxoprofen, diclofenac, felbinac, flurbiprofen, or indomethacin) applied to the paw for 6 h per day for 5 days. The pain threshold was evaluated using a flexion test of the ankle joint, and the inflamed paw edema was evaluated using a plethysmometer. cyclooxygenase (COX)-1 and COX-2 inhibition was evaluated using human recombinant proteins. Multiple applications of SFPP exerted a significant analgesic effect from the first day of application as compared to the other NSAID patches. In terms of paw edema, SFPP decreased edema from the second day after application, Multiple applications of SFPP were superior to those of other NSAID patches, in terms of the analgesic effect with multiple applications. These results suggest that SFPP may be a beneficial patch for providing analgesic and anti-inflammatory effects clinically. Drug Dev Res 77 : 206-211, 2016. © 2016 The Authors Drug Development Research Published by Wiley Periodicals, Inc.
authors.affiliation: Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Sugimoto
authors.affiliation: Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Toda
authors.affiliation: Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Hori
authors.affiliation: Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Mitani
authors.affiliation: Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ichihara
authors.affiliation: Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Sekine
authors.affiliation: Research Headquarters, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Kaku
authors.affiliation: Development Headquarters, Taisho Pharmaceutical Co., Ltd., Tokyo, Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Otsuka
authors.affiliation: Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsumoto
mesh_terms: D000279:Administration, Cutaneous; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D051545:Cyclooxygenase 1 / Q000187:drug effects / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000187:drug effects / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy; D005480:Flurbiprofen / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009161:Mycobacterium; D010146:Pain / Q000188:drug therapy; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D011917:Rats, Inbred Lew; D011994:Recombinant Proteins; D057968:Transdermal Patch
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011994:Recombinant Proteins; D005480:Flurbiprofen; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2
keywords: NSAIDs; S(+)-flurbiprofen; analgesic; anti-inflammatory