title: Pilot study on the feasibility of limited focused real-time echocardiography during pediatric renal transplantation.
abstract: Pediatric renal transplantation protocols describe supraphysiological blood pressure and CVP to optimize graft perfusion. Ideal CVP and blood pressure targets in children are uncertain and difficult to achieve and/or sustain without incurring morbidity. We correlated intra-operative ECHO with standard monitoring to assess intravascular volume at critical intra-operative stages. A feasibility pilot study of real-time limited ECHO images during four critical stages of pediatric renal transplantation (baseline; venous and arterial clamps on; clamps off; 5-10 min post-clamp release) was conducted. Simultaneous CVP, SBP and DBP measurements were obtained with ECHO images. A surgeon blinded to the ECHO study assessed the quality of graft perfusion. Thirteen patients (nine TTE and four TEE) were enrolled. The CI increased in all patients at vascular clamp removal and the post-resuscitation period (average increase in CI 20%, range 8-49%). SBP, DBP and CVP were inconsistent. ECHO data confirmed an appropriate CI increase even when the targeted CVP and BP values described in protocols were not achieved. The surgeons were satisfied with graft perfusion in 12 of 13 cases, with one locally obstructed vessel. We suggested that aiming for fixed targets in CVP and BP is not necessary to augment CI and encourage good renal perfusion.
authors.affiliation: Department of Anesthesia, Hospital for Sick Children, Toronto, Ontario, Canada.|Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Katherine
authors.identifier: http://orcid.org/0000-0001-8663-3578
authors.initials: K
authors.lastname: Taylor
authors.affiliation: Department of Urology, Hospital for Sick Children, Toronto, Ontario, Canada.|Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Armando
authors.initials: A
authors.lastname: Lorenzo
authors.affiliation: Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.|Department of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Luc
authors.initials: L
authors.lastname: Mertens
authors.affiliation: Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.|Department of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Andreea
authors.initials: A
authors.lastname: Dragulescu
mesh_terms: D000293:Adolescent; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D003199:Computer Systems; D004452:Echocardiography / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D007668:Kidney / Q000098:blood supply*; D016030:Kidney Transplantation; D008297:Male; D016343:Monitoring, Intraoperative / Q000379:methods*; D017063:Outcome Assessment, Health Care; D010865:Pilot Projects; D011446:Prospective Studies; D016037:Single-Blind Method
keywords: anesthesia; echocardiography; pediatric renal transplantation; ultrasound