title: Enantioselective intermolecular cross Rauhut-Currier reactions of activated alkenes with acrolein.
abstract: The enantioselective intermolecular cross Rauhut-Currier reaction of acrolein with active olefins has been a long-standing challenge because of the competitive MBH reaction and polymerization. Herein a highly enantioselective intermolecular cross Rauhut-Currier reaction of acrolein with 3-acyl acrylates and 2-ene-1,4-diones, which is enabled by newly designed Peng-Phos catalysts. This method is scalable and highly enantioselective (up to 96% ee). Several transformations of the R-C products are carried out to showcase the synthetic utility.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, P. R. China. jlzhang@chem.ecnu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: Mengna
authors.initials: M
authors.lastname: Tao
authors.forename: Xiao
authors.initials: X
authors.lastname: Su
authors.forename: Qingjie
authors.initials: Q
authors.lastname: Zhao
authors.forename: Junliang
authors.initials: J
authors.lastname: Zhang