title: Sarcomeres and Cardiac Growth: Tension in the Relationship.
abstract: Genetic mutations in the cardiomyocyte contractile apparatus cause aberrant cardiac growth categorized morphologically as hypertrophic or dilated. A recent study leverages an array of mutant mouse models to extrapolate a new integrated parameter: the myofilament 'tension index', which predicts patterns of cardiac growth resulting from individual sarcomeric mutations. These findings may inform genotype-specific therapies.
authors.affiliation: Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA; Department of Medicine, Division of Cardiology, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA 94143, USA. Electronic address: saptarsi.haldar@gladstone.ucsf.edu.
authors.forename: Saptarsi M
authors.initials: SM
authors.lastname: Haldar
authors.affiliation: Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA; Department of Pediatrics, Division of Cardiology, UCSF School of Medicine, San Francisco, CA 94143, USA. Electronic address: deepak.srivastava@gladstone.ucsf.edu.
authors.forename: Deepak
authors.initials: D
authors.lastname: Srivastava
mesh_terms: D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000235:genetics* / Q000473:pathology; D002312:Cardiomyopathy, Hypertrophic / Q000235:genetics* / Q000473:pathology; D005838:Genotype; D006321:Heart / Q000254:growth & development; D006801:Humans; D051379:Mice; D009124:Muscle Proteins / Q000235:genetics*; D009154:Mutation; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology*; D012518:Sarcomeres / Q000235:genetics* / Q000473:pathology
chemical_list: D009124:Muscle Proteins