title: Combination Therapy of Simeprevir and Sofosbuvir in Recurrent HCV Genotype 4 After Liver Retransplantation: Case Report.
abstract: BACKGROUND
  The treatment of hepatitis C virus (HCV) infection is evolving rapidly. Many studies have been completed during the last 2 years, with more studies still in progress. The management of recurring HCV infection following liver organ transplantation remains very challenging, especially for HCV genotype 4 (GT-4). More research is needed in this area.
  
  
  METHODS
  We report on a patient with a recurring HCV infection and fibrosing cholestatic hepatitis following liver retransplantation, who was successfully treated with a combination therapy of simeprevir and sofosbuvir without interferon/ribavirin. As far as we know, this is the first reported case of this kind.
  
  
  CONCLUSIONS
  This information may be of importance and inform future management of patients with recurrent HCV infections following liver transplantation.
authors.affiliation: Department of Hepatobiliary and Transplant Surgery, Jordan Hospital, Amman, Jordan.
authors.forename: Aiman
authors.initials: A
authors.lastname: Obed
authors.affiliation: Department of Hepatology, Jordan Hospital, Amman, Jordan.
authors.forename: Anwar
authors.initials: A
authors.lastname: Jarrad
authors.affiliation: Department of Hepatobiliary and Transplant Surgery, Jordan Hospital, Amman, Jordan.
authors.forename: Abdalla
authors.initials: A
authors.lastname: Bashir
authors.affiliation: Department of Hepatology, Clinic for Gastroenterology and Hepatology, Kassel, Germany.
authors.forename: Gero
authors.initials: G
authors.lastname: Moog
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D000069616:Simeprevir / Q000627:therapeutic use*; D000069474:Sofosbuvir / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D000069616:Simeprevir; D000069474:Sofosbuvir