title: Optical coherence tomography manifestations of primary vitreoretinal lymphoma.
abstract: BACKGROUND
  Primary vitreoretinal lymphoma (PVRL), a subset of primary central nervous system lymphoma (PCNSL), is a high-grade malignant tumor that shows various chorioretinal findings. Optical coherence tomography (OCT) is useful for detecting these lesions, and various abnormalities on OCT images have been reported. The purpose of this report was to investigate retrospectively the OCT manifestations of various disease stages and compare the manifestations of pretreatment, recurrent, and chronic cases.
  
  
  METHODS
  We reviewed the medical charts and OCT images of 38 consecutive cases with PVRL. When abnormalities were detected on OCT images, the patients were classified based on the treatment of the primary disease: pretreatment if not treated, recurrent if treated previously, and chronic when chronic changes.
  
  
  RESULTS
  Twenty-six eyes (20 cases) had abnormalities in the post-pole OCT images, i.e., 16 eyes (12 cases) were in the pretreatment group, seven eyes (five cases) were in the recurrent group, and five eyes (five cases) were in the chronic group. Two eyes (two cases) had abnormalities on OCT in the pretreatment and recurrent or chronic stages. The pretreatment and recurrent groups had subretinal or retinal pigment epithelium (RPE) level abnormalities more often than intraretinal changes. Twelve of 16 pretreated eyes and all seven eyes with recurrent disease had subretinal or RPE level abnormalities. One pretreatment case and three recurrent cases had atypical OCT manifestations of intraretinal (round lesions) or epiretinal changes (villous-shaped lesions).
  
  
  CONCLUSIONS
  Although pretreatment cases and recurrent cases showed similar OCT abnormalities and the specific changes in the various disease stages were unclarified, collecting OCT data from various disease stages will facilitate detection of typical OCT changes of PVRL and lead to early diagnosis and treatment.
authors.affiliation: Department of Ophthalmology, Japan Community Health Care Organization Osaka Hospital, 4-2-78, Fukushima, Fukushima-ku, Osaka City, 553-0003, Japan.
authors.forename: Teiko
authors.initials: T
authors.lastname: Saito
authors.affiliation: Department of Ophthalmology, Japan Community Health Care Organization Osaka Hospital, 4-2-78, Fukushima, Fukushima-ku, Osaka City, 553-0003, Japan. nohguro@gmail.com.|Department of Ophthalmology, Osaka University Medical School, 2-2 Yamadaoka E7, Suita, Osaka, 565-0871, Japan. nohguro@gmail.com.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ohguro
authors.affiliation: Department of Ophthalmology, Osaka University Medical School, 2-2 Yamadaoka E7, Suita, Osaka, 565-0871, Japan.
authors.forename: Chiharu
authors.initials: C
authors.lastname: Iwahashi
authors.affiliation: Department of Ophthalmology, Osaka University Medical School, 2-2 Yamadaoka E7, Suita, Osaka, 565-0871, Japan.
authors.forename: Noriyasu
authors.initials: N
authors.lastname: Hashida
mesh_terms: D000368:Aged; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D019572:Retinal Neoplasms / Q000175:diagnosis*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014822:Vitreous Body / Q000473:pathology*
keywords: Intraocular lymphoma; Optical coherence tomography; Primary vitreoretinal lymphoma