title: Protective effect of mesoporous silica particles on encapsulated folates.
abstract: Mesoporous silica particles (MSPs) are considered suitable supports to design gated materials for the encapsulation of bioactive molecules. Folates are essential micronutrients which are sensitive to external agents that provoke nutritional deficiencies. Folates encapsulation in MSPs to prevent degradation and to allow their controlled delivery is a promising strategy. Nevertheless, no information exists about the protective effect of MSPs encapsulation to prevent their degradation. In this work, 5-formyltetrahydrofolate (FO) and folic acid (FA) were entrapped in MSPs functionalized with polyamines, which acted as pH-dependent molecular gates. The stability of free and entrapped vitamins after acidic pH, high temperature and light exposure was studied. The results showed the degradation of FO after high temperature and acidic pH, whereas entrapped FO displayed enhanced stability. Free FA was degraded by light, but MSPs stabilized the vitamin. The obtained results point toward the potential use of MSPs as candidates to enhance stability and to improve the bioavailability of functional biomolecules.
authors.affiliation: Grupo de Investigación e Innovación Alimentaria, Departamento de Tecnología de Alimentos, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain. Electronic address: maruiri@etsia.upv.es.
authors.forename: María
authors.initials: M
authors.lastname: Ruiz-Rico
authors.affiliation: Grupo de Investigación e Innovación Alimentaria, Departamento de Tecnología de Alimentos, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.
authors.forename: Hanna
authors.initials: H
authors.lastname: Daubenschüz
authors.affiliation: Grupo de Investigación e Innovación Alimentaria, Departamento de Tecnología de Alimentos, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.
authors.forename: Édgar
authors.initials: É
authors.lastname: Pérez-Esteve
authors.affiliation: Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Unidad Mixta Universitat Politècnica de València y Universitat de València, Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN).
authors.forename: María D
authors.initials: MD
authors.lastname: Marcos
authors.affiliation: Institut de Ciència dels Materials (ICMUV), Universitat de València, P.O. Box 22085, 46071 Valencia, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Amorós
authors.affiliation: Centro de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Unidad Mixta Universitat Politècnica de València y Universitat de València, Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN).
authors.forename: Ramón
authors.initials: R
authors.lastname: Martínez-Máñez
authors.affiliation: Grupo de Investigación e Innovación Alimentaria, Departamento de Tecnología de Alimentos, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Barat
mesh_terms: D005492:Folic Acid / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008027:Light; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D016062:Porosity; D033362:Powder Diffraction; D012822:Silicon Dioxide / Q000737:chemistry*; D013696:Temperature
chemical_list: D012822:Silicon Dioxide; D005492:Folic Acid
keywords: 5-Formyltetrahydrofolate; Controlled release; Encapsulation; Folic acid; Mesoporous silica particles; Stability