title: [Allergy to neuromuscular blocking agents].
abstract: Allergy to neuromuscular blocking agents (NMBAs) has been the first cause of perioperative anaphylaxis for decades, in most countries. The most frequently involved agents are suxamethonium and rocuronium. The allergy work-up is compulsory to demonstrate or rule out allergy to NMBAs, if there is a compatible clinical history. Doing otherwise exposes the patient to death if the same or related NMBA is re-injected. In cases of true allergy, assessing cross-reactivity to other NMBAs is mandatory. The cross-sensitization hypothesis is presently being investigated and if confirmed, it could allow primary prevention measures to be implemented.
authors.affiliation: Centre hospitalier universitaire de Montpellier, hôpital Arnaud-de-Villeneuve, département de pneumologie et addictologie, unité exploration des allergies, 34295 Montpellier, France; Sorbonne universités, UPMC Paris 06, UMR_S 1136, institut Pierre-Louis d'épidémiologie et de santé publique, équipe EPAR, 75013 Paris, France. Electronic address: a-chiriac@chu-montpellier.fr.
authors.forename: Anca-Mirela
authors.initials: AM
authors.lastname: Chiriac
authors.affiliation: Centre hospitalier universitaire de Montpellier, hôpital Arnaud-de-Villeneuve, département de pneumologie et addictologie, unité exploration des allergies, 34295 Montpellier, France; Sorbonne universités, UPMC Paris 06, UMR_S 1136, institut Pierre-Louis d'épidémiologie et de santé publique, équipe EPAR, 75013 Paris, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Demoly
mesh_terms: D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects*
chemical_list: D009466:Neuromuscular Blocking Agents