title: Serum Endothelial Cell-Specific Molecule 1 (Endocan) Levels in Patients With Acute Myocardial Infarction and Its Clinical Significance.
abstract: Endothelial dysfunction is involved in the process of acute myocardial infarction (AMI), that is, the endothelial cell-specific molecule 1 (ESM-1; endocan) is a novel endothelial dysfunction marker. However, the relationship between patients with AMI and serum ESM-1 levels is not very clear. Patients with AMI (n = 216) and a control group (n = 60) without AMI were included in the study. High-sensitivity C-reactive protein (hsCRP) was measured, and the severity of AMI was assessed by a modified Gensini stenosis scoring system. Serum ESM-1 levels were significantly higher in the AMI group ( P < .05). High-sensitivity C-reactive protein levels were also significantly higher in the AMI group ( P < .05). In patients with AMI, serum ESM-1 levels were not significantly correlated with hsCRP levels. There was no significant correlation between serum ESM-1 level and Gensini score. Our findings suggest that serum ESM-1 levels may be a novel biomarker of endothelial dysfunction in patients with AMI.
authors.affiliation: 1 Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People's Republic of China.
authors.forename: Chong-Rong
authors.initials: CR
authors.lastname: Qiu
authors.affiliation: 1 Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People's Republic of China.|2 Department of Cardiology, Xuzhou Institute of Cardiovascular Disease, Xuzhou, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.affiliation: 3 Department of Pathological and Physiological, Medical College of Jiangsu University, Zhenjiang, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Sui
authors.affiliation: 1 Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: 1 Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wei
authors.affiliation: 3 Department of Pathological and Physiological, Medical College of Jiangsu University, Zhenjiang, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: 1 Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People's Republic of China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zhu
authors.affiliation: 1 Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
authors.affiliation: 1 Department of Cardiology, Xuzhou Central Hospital, Xuzhou, People's Republic of China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zong
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D017023:Coronary Angiography; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D009363:Neoplasm Proteins / Q000097:blood*; D010865:Pilot Projects; D011509:Proteoglycans / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans; D002097:C-Reactive Protein
keywords: Gensini score; acute myocardial infarction; biomarker; endocan; endothelial cell–specific molecule 1; inflammation