title: New polyprenyl phosphate based preparation Fortepren(®) as promising cytokine regulationg antiviral remedy.
abstract: Fortepren(®), a product of the phosphorylation of polyprenols from fir needles (with sodium polyprenyl phosphate being the main active ingredient), belongs to the class of antiviral drugs with immunomodulating activity. Fortepren(®) may be used as the drug of choice in the treatment of herpes diseases. It was shown that treatment with Fortepren(®) of patients with a chronic recurrent herpes infection after acute phase termination with acyclovir decreased the recurrence rate, as well as the severity of local symptoms. Fortepren(®) treatment of patients with a high incidence of recurrent herpes infection led to an increase in the interferon-producing ability of leucocytes stimulated with NDV, as well as in the production of key cytokines (IL-1β, IL-15, MIP-1α, IFN-γ, IL-12 (p40), TNF-α, IFN-α2, IL-12 (p70), IL-6) taking part in the protection against viral infection. Data suggest that the action of the drug is directed, first of all, to the cells responsible for the natural resistance of the organism (macrophages, dendritic cells, etc.). The activation of natural immunity appears to be a leading mechanism of protection from herpesviral infection under the influence of polyprenyl phosphate.
authors.affiliation: N. F. Gamaleya Federal Research Center for Epidemiology and Microbiology of the Ministry of Health of Russian Federation, 18, Gamaleya Str., Moscow 123098, Russia. Electronic address: proninalexander@yandex.ru.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Pronin
authors.affiliation: N. F. Gamaleya Federal Research Center for Epidemiology and Microbiology of the Ministry of Health of Russian Federation, 18, Gamaleya Str., Moscow 123098, Russia.
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Narovlyansky
authors.affiliation: National Research Center Institute of Immunology of the Federal Medical Biological Agency of the Russian Federation, 24-2, Kashirskoe Shosse, Moscow 115478, Russia.
authors.forename: Andrey E
authors.initials: AE
authors.lastname: Shulzhenko
authors.affiliation: N. F. Gamaleya Federal Research Center for Epidemiology and Microbiology of the Ministry of Health of Russian Federation, 18, Gamaleya Str., Moscow 123098, Russia.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Sanin
authors.affiliation: N. F. Gamaleya Federal Research Center for Epidemiology and Microbiology of the Ministry of Health of Russian Federation, 18, Gamaleya Str., Moscow 123098, Russia.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Sedov
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016207:Cytokines / Q000276:immunology*; D006561:Herpes Simplex / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D010755:Organophosphates / Q000494:pharmacology* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D016207:Cytokines; D010755:Organophosphates
keywords: Cytokines; Polyprenyl phosphates; Virus infections