title: Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease.
abstract: OBJECTIVE
  To evaluate the performance of elastography by ultrasound with acoustic radiation force impulse (ARFI) in determining fibrosis stage in patients with alcoholic liver disease (ALD) undergoing alcoholic detoxification in relation to biopsy.
  
  
  METHODS
  Eighty-three patients with ALD undergoing detoxification were prospectively enrolled. Each patient underwent ARFI imaging and a liver biopsy on the same day. Fibrosis was staged according to the METAVIR scoring system. The median of 10 valid ARFI measurements was calculated for each patient.
  
  
  RESULTS
  Sixty-nine males and thirteen females (one patient excluded due to insufficient biopsy size) were assessed with a mean alcohol consumption of 132.4 ± 128.8 standard drinks per week and mean cumulative year duration of 17.6 ± 9.5 years. Sensitivity and specificity were respectively 82.4% (0.70-0.95) and 83.3% (0.73-0.94) (AUROC = 0.87) for F ≥ 2 with a cut-off value of 1.63m/s; 82.4% (0.64-1.00) and 78.5% (0.69-0.89) (AUROC = 0.86) for F ≥ 3 with a cut-off value of 1.84m/s; and 92.3% (0.78-1.00] and 81.6% (0.72-0.90) (AUROC = 0.89) for F = 4 with a cut-off value of 1.94 m/s.
  
  
  CONCLUSIONS
  ARFI is an accurate, non-invasive and easy method for assessing liver fibrosis in patients with ALD undergoing alcoholic detoxification.
authors.affiliation: Anita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
authors.forename: Anita
authors.initials: A
authors.lastname: Kiani
authors.affiliation: Anita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Brun
authors.affiliation: Anita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Lainé
authors.affiliation: Anita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Turlin
authors.affiliation: Anita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
authors.forename: Jeff
authors.initials: J
authors.lastname: Morcet
authors.affiliation: Anita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Michalak
authors.affiliation: Anita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
authors.forename: Antonia
authors.initials: A
authors.lastname: Le Gruyer
authors.affiliation: Anita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
authors.forename: Ludivine
authors.initials: L
authors.lastname: Legros
authors.affiliation: Anita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
authors.forename: Edouard
authors.initials: E
authors.lastname: Bardou-Jacquet
authors.affiliation: Anita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Gandon
authors.affiliation: Anita Kiani, Vanessa Brun, Yves Gandon, Department of Abdominal Imaging, Rennes University Hospital, 35033 Rennes, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Moirand
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001706:Biopsy; D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results; D012720:Severity of Illness Index
keywords: Acoustic radiation force impulse; Alcoholic liver disease; Elastography; Fibrosis; Non-invasive