title: A Prospective Randomized Controlled Trial to Study the Impact of a Nutrition-Sensitive Intervention on Adult Women With Cancer Cachexia Undergoing Palliative Care in India.
abstract: Advanced cancer patients with disease progression develop cachexia. Nevertheless, cancer patients at nutritional risk have shown improved body weight and quality of life with oral nutritional supplements.
  
  
  
  This was a randomized controlled trial in adult female cancer patients (n = 63) attending palliative clinics, with symptoms of cachexia. Eligible patients were randomly distributed into control (n = 33) and intervention (n = 30) groups. Both groups were provided with nutritional and physical activity counseling, but the intervention group received an additional 100 g of Improved Atta (IAtta) for 6 months daily consumption. This study was designed to assess the efficacy of IAtta (with counseling) in enhancing the health status of cachexic patients. Anthropometric measurements, dietary intake, physical activity level and quality of life parameters were assessed at baseline, after 3 months, and at the end of 6 months.
  
  
  
  Patients in the control group (n = 15) had significantly decreased body weight ( P = .003), mid-upper-arm circumference ( P = .002), and body fat ( P = .002) by the end of intervention. A trend of body weight gain in the intervention group (n = 17; P = .08) and significant increase of body fat ( P = .002) was observed; moreover, patients reported a significant improvement in fatigue ( P = .002) and appetite scores ( P = .006) under quality-of-life domains at the end of intervention.
  
  
  
  Embedding a nutrition-sensitive intervention ( IAtta ) within Indian palliative care therapy may improve quality of life and stabilize body weight in cancer cachexia patients.
authors.affiliation: 1 University of Westminster, London, UK.
authors.forename: Neha
authors.initials: N
authors.lastname: Kapoor
authors.affiliation: 1 University of Westminster, London, UK.
authors.forename: Jane
authors.initials: J
authors.lastname: Naufahu
authors.affiliation: 2 London Metropolitan University, London, UK.
authors.forename: Sundus
authors.initials: S
authors.lastname: Tewfik
authors.affiliation: 3 The All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Sushma
authors.initials: S
authors.lastname: Bhatnagar
authors.affiliation: 3 The All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Garg
authors.affiliation: 1 University of Westminster, London, UK.
authors.forename: Ihab
authors.initials: I
authors.lastname: Tewfik
mesh_terms: D000328:Adult; D001835:Body Weight / Q000502:physiology; D002100:Cachexia / Q000503:physiopathology*; D019587:Dietary Supplements; D005260:Female; D005502:Food; D006801:Humans; D007194:India; D008875:Middle Aged; D009369:Neoplasms / Q000503:physiopathology*; D009752:Nutritional Status / Q000502:physiology*; D010166:Palliative Care; D011446:Prospective Studies; D011788:Quality of Life
keywords: IAtta; cachexia; nutrition-sensitive intervention; palliative care; quality of life