title: Closing in on Mass Production of Mature Human Beta Cells.
abstract: Human pluripotent stem cell differentiation protocols based on mimicking developmental pathways are getting close to generating fully fledged pancreatic endocrine cells, including insulin-producing beta cells. However, challenges remain in identifying pathways to trigger the attainment of robust glucose responsiveness that occurs postnatally in beta cells.
authors.affiliation: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: tim.kieffer@ubc.ca.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Kieffer
mesh_terms: D018929:Cell Culture Techniques / Q000379:methods*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology*; D013234:Stem Cells / Q000166:cytology