title: Sexually dimorphic myeloid inflammatory and metabolic responses to diet-induced obesity.
abstract: It is well known in clinical and animal studies that women and men have different disease risk as well as different disease physiology. Women of reproductive age are protected from metabolic and cardiovascular disease compared with postmenopausal women and men. Most murine studies are skewed toward the use of male mice to study obesity-induced metabolic dysfunction because of similar protection in female mice. We have investigated dietary obesity in a mouse model and have directly compared inflammatory responses in males and females. In this review we will summarize what is known about sex differences in diet-induced inflammation and will summarize our data on this topic. It is clear that sex differences in high-fat diet-induced inflammatory activation are due to cell intrinsic differences in hematopoietic responses to obesogenic cues, but further research is needed to understand what leads to sexually dimorphic responses.
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: C
authors.initials: C
authors.lastname: Griffin
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: N
authors.initials: N
authors.lastname: Lanzetta
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan.
authors.forename: L
authors.initials: L
authors.lastname: Eter
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan ksinger@umich.edu.
authors.forename: K
authors.initials: K
authors.lastname: Singer
mesh_terms: D000818:Animals; D059305:Diet, High-Fat / Q000379:methods; D004041:Dietary Fats / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D006410:Hematopoiesis / Q000276:immunology*; D058847:Inflammasomes / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D008297:Male; D051379:Mice; D018448:Models, Immunological; D009765:Obesity / Q000276:immunology*; D012727:Sex Characteristics
chemical_list: D004041:Dietary Fats; D058847:Inflammasomes
keywords: diabetes; high-fat diet; myelopoisis; obesity; sexual dimorphism