title: Effects of Ripasudil Hydrochloride Hydrate Instillation on Pupil Dynamics.
abstract: We investigated the effects of instillation of ripasudil hydrochloride hydrate (GLANATEC®) on pupil dynamics.
  
  
  
  Fourteen healthy participants (mean age: 30 years), who had no ophthalmic diseases other than refractive error, were enrolled in this study. A single dose of GLANATEC®was instilled into the left eye only. The pupillary response was measured before and 30 and 120 min after instillation; we also measured intraocular pressure (IOP) at the same time points.
  
  
  
  The IOP in the left eye was significantly lower at both 30 (p < 0.05) and 120 (p < 0.01) min after instillation than at baseline, whereas that in the right eye was not significantly different from baseline at either of the measured post-instillation time points. In contrast, the pupillary response did not significantly differ between the three time points.
  
  
  
  A single instillation of low concentration GLANATEC®may have no effect on pupil diameter and pupillary response.
authors.affiliation: a Department of Ophthalmology , Kitasato University School of Medicine , Sagamihara , Kanagawa , Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Satou
authors.affiliation: a Department of Ophthalmology , Kitasato University School of Medicine , Sagamihara , Kanagawa , Japan.|b Department of Orthoptics and Visual Science , Kitasato University School of Allied Health Sciences , Sagamihara , Kanagawa , Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ishikawa
authors.affiliation: b Department of Orthoptics and Visual Science , Kitasato University School of Allied Health Sciences , Sagamihara , Kanagawa , Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Asakawa
authors.affiliation: a Department of Ophthalmology , Kitasato University School of Medicine , Sagamihara , Kanagawa , Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Goseki
authors.affiliation: a Department of Ophthalmology , Kitasato University School of Medicine , Sagamihara , Kanagawa , Japan.
authors.forename: Kimiya
authors.initials: K
authors.lastname: Shimizu
mesh_terms: D000287:Administration, Topical; D000328:Adult; D003228:Conjunctiva / Q000098:blood supply; D003623:Dark Adaptation; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced; D007429:Intraocular Pressure / Q000187:drug effects; D007546:Isoquinolines / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009130:Muscle, Smooth / Q000502:physiology*; D009883:Ophthalmic Solutions; D011680:Pupil / Q000187:drug effects*; D012025:Reflex, Pupillary / Q000502:physiology*; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology*; D054460:rho-Associated Kinases / Q000037:antagonists & inhibitors*
chemical_list: D007546:Isoquinolines; C584679:K-115; D009883:Ophthalmic Solutions; D013449:Sulfonamides; D054460:rho-Associated Kinases
keywords: Ciliary muscle; iris dilator; iris sphincter; pupillary response; ripasudil hydrochloride hydrate