title: Real-time simultaneous single snapshot of optical properties and blood flow using coherent spatial frequency domain imaging (cSFDI).
abstract: In this work we present and validate a wide-field method for the real-time mapping of tissue absorption, scattering and blood flow properties over wide regions of tissue (15 cm x 15 cm) with high temporal resolution (50 frames per second). We achieve this by applying Fourier Domain demodulation techniques to coherent spatial frequency domain imaging to extract optical properties and speckle flow index from a single snapshot. Applying this technique to forearm reactive hyperemia protocols demonstrates the ability to resolve intrinsic physiological signals such as the heart beat waveform and the buildup of deoxyhemoglobin associated with oxygen consumption.
authors.affiliation: Laser Microbeam and Medical Program, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612, USA; Department of Biomedical Engineering, University of California, Irvine, California 92697, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Ghijsen
authors.affiliation: Laser Microbeam and Medical Program, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612, USA; Department of Biomedical Engineering, University of California, Irvine, California 92697, USA; Department of Surgery, University of California, Irvine Medical Center, Orange, California 92868, USA.
authors.forename: Bernard
authors.initials: B
authors.lastname: Choi
authors.affiliation: Laser Microbeam and Medical Program, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612, USA; Department of Surgery, University of California, Irvine Medical Center, Orange, California 92868, USA.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Durkin
authors.affiliation: University of Strasbourgh, ICube Laboratory, 300 Bd S. Brant, 67412 Illkirch, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Gioux
authors.affiliation: Laser Microbeam and Medical Program, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612, USA; Department of Biomedical Engineering, University of California, Irvine, California 92697, USA; Department of Surgery, University of California, Irvine Medical Center, Orange, California 92868, USA.
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Tromberg
keywords: (110.0113) Imaging through turbid media; (110.6150) Speckle imaging; (170.3880) Medical and biological imaging