title: A possible heterozygous advantage in muscular dystrophy.
abstract: In certain autosomal recessive disorders there is suggestive evidence that heterozygous carriers may have some selective advantage over normal homozygotes. These include, for example, cystic fibrosis, Tay-Sachs disease and phenylketonuria. The best example so far, however, is that of significant heterozygous advantage in sickle-cell anaemia with increased resistance to falciparum malaria.
authors.affiliation: Green Templeton College, University of Oxford, Oxford, UK; and University of Edinburgh, Scotland. alan.emery@gtc.ox.ac.uk.
authors.forename: A E H
authors.initials: AE
authors.lastname: Emery
mesh_terms: D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D009136:Muscular Dystrophies / Q000235:genetics*; D065840:Protective Factors