title: Relationship between negative affect and smoking topography in heavy drinking smokers.
abstract: Heavy drinking smokers represent a sizeable subgroup of smokers for whom nicotine deprivation and alcohol use increases the urge to smoke in the laboratory and predicts lapses during smoking cessation. The manner in which individuals smoke a cigarette (i.e. smoking topography) provides a reliable index of smoking intensity and reinforcement, yet the effects of affect on smoking topography have not been thoroughly examined in heavy drinking smokers. The current study examined how affect and nicotine deprivation predict smoking behavior as participants (N=27) smoked one cigarette using a smoking topography device after 12-h of nicotine abstinence and after a priming dose of alcohol (target BrAC=0.06g/dl). Primary smoking topography measures were puff volume, velocity, duration, and inter-puff interval (IPI). The effect of nicotine deprivation was measured by the Minnesota Nicotine Withdrawal Scale (MNWS) and the Profile of Mood States (POMS). Measures were obtained at baseline (i.e. 12-h of nicotine abstinence and pre-alcohol) and 30-minutes after alcohol administration (i.e. peak BrAC). Results revealed post-priming negative affect significantly moderated the trajectories of puff volume, puff duration and IPI (p's<0.05) over the course of the cigarette, such that those with greater negative affect had flatter slopes for volume and duration and increasingly infrequent puffs. Our results suggest that baseline and post-priming negative affect following nicotine deprivation alters smoking patterns and increases nicotine exposure throughout a single cigarette. Future studies need to examine differential amounts of nicotine deprivation on response to alcohol and smoking in heavy drinking smokers.
authors.affiliation: Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, United States.
authors.forename: ReJoyce
authors.initials: R
authors.lastname: Green
authors.affiliation: Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, United States.
authors.forename: Spencer
authors.initials: S
authors.lastname: Bujarski
authors.affiliation: Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, United States.
authors.forename: Daniel J O
authors.initials: DJ
authors.lastname: Roche
authors.affiliation: Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095, United States. Electronic address: lararay@psych.ucla.edu.
authors.forename: Lara A
authors.initials: LA
authors.lastname: Ray
mesh_terms: D000328:Adult; D000339:Affect; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000523:psychology*; D000073865:Cigarette Smoking / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D000074285:Smokers / Q000523:psychology* / Q000706:statistics & numerical data; D014029:Tobacco Use Disorder / Q000453:epidemiology* / Q000523:psychology
keywords: Heavy drinking smokers; Negative affect; Nicotine deprivation; Puff duration; Puff volume; Smoking topography