title: Prostate cancer characteristics and outcome in renal transplant recipients: results from a contemporary single center study.
abstract: Prostate cancer (PCa) incidence is expected to increase in renal transplant recipients (RTR) with no clear nor contemporary data on management and oncological outcome.
  
  
  
  We conducted a retrospective single center study of RTR diagnosed with PCa after transplantation between 2000 and 2013. Demographics, PCa characteristics, and treatment were assessed. For each RTR in radical prostatectomy (RP) subset, we included 4 non-organ transplant patients who underwent RP by the same surgeons, and compared pre-operative and post-operative oncological features, and biochemical recurrence (BCR) rate.
  
  
  
  Twenty-four RTR were included (PCa incidence 1.5%). Mean follow-up was 47 months. PCa was mostly localized (n=21, 87.5%) with treatments including RP (n=16, 76.2%), brachytherapy (n=3, 14.3%), radiation therapy (n=1, 4.7%), and active surveillance (n=1, 4.7%). No graft loss due to PCa treatment was reported. Nineteen RTR with localized PCa (90.5%) were free from BCR. Considering RP subset, no difference in PCa characteristics at diagnosis and BCR rate was found between RTR (n=16) and control patients (n=64).
  
  
  
  Localized PCa following renal transplantation was not associated with adverse features as compared with non-transplant patients. Standard treatments could be proposed to RTR with satisfying results both on oncological outcome and graft function.
authors.affiliation: Department of Urology and Transplant Surgery, Hôpital européen Georges-Pompidou, AP-HP, Paris, France.|Université Paris Descartes, Paris, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Pettenati
authors.affiliation: Université Paris Descartes, Paris, France.|Department of Statistics, Computing and Public Health, Hôpital européen Georges-Pompidou, AP-HP, Paris, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Jannot
authors.affiliation: Department of Urology and Transplant Surgery, Hôpital européen Georges-Pompidou, AP-HP, Paris, France.|Université Paris Descartes, Paris, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Hurel
authors.affiliation: Université Paris Descartes, Paris, France.|Department of Pathology, Hôpital Necker, AP-HP, Paris, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Verkarre
authors.affiliation: Université Paris Descartes, Paris, France.|Department of Nephrology and Transplantation, Hôpital Necker, AP-HP, Paris, France.
authors.forename: Henri
authors.initials: H
authors.lastname: Kreis
authors.affiliation: Université Paris Descartes, Paris, France.|Department of Onco-Radiotherapy, Hôpital européen Georges-Pompidou, AP-HP, Paris, France.
authors.forename: Martin
authors.initials: M
authors.lastname: Housset
authors.affiliation: Université Paris Descartes, Paris, France.|Department of Nephrology and Transplantation, Hôpital Necker, AP-HP, Paris, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Legendre
authors.affiliation: Department of Urology and Transplant Surgery, Hôpital européen Georges-Pompidou, AP-HP, Paris, France.|Université Paris Descartes, Paris, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Méjean
authors.affiliation: Department of Urology and Transplant Surgery, Hôpital européen Georges-Pompidou, AP-HP, Paris, France.|Université Paris Descartes, Paris, France.
authors.forename: Marc-Olivier
authors.initials: MO
authors.lastname: Timsit
mesh_terms: D000368:Aged; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D066027:Transplant Recipients
keywords: biochemical recurrence; demographics; localized; outcome; prostate cancer; radical prostatectomy; renal transplant