title: Comparison of amorphous states prepared by melt-quenching and cryomilling polymorphs of carbamazepine.
abstract: The physical state of amorphous powder obtained by cryomilling forms I and III of carbamazepine (CBZ) were analyzed from low-wavenumber Raman spectroscopy investigations and compared to that of the quenched liquid. This analysis has shown subtle structural modifications between the amorphous states prepared by melt-quenching and cryomilling polymorphs I and III of CBZ. Moreover, two different non-isothermal crystallization mechanisms from these two different types of amorphous states were revealed, in agreement with calorimetric analyzes. Raman spectroscopy and differential scanning calorimetry experiments performed on cryomilled forms I and III of CBZ, provide information on the bimodal crystallization, observed upon heating several amorphous organic crystalline materials produced by milling. This study clearly shows that milling gives the opportunity to explore new amorphous states which cannot be achieved using the classical melt-quenching method.
authors.affiliation: Université Lille Nord de France, F-59000 Lille, France; USTL UMET UMR 8207 F-59655 Villeneuve d'Ascq, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Guinet
authors.affiliation: Université Lille Nord de France, F-59000 Lille, France; USTL UMET UMR 8207 F-59655 Villeneuve d'Ascq, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Paccou
authors.affiliation: Université Lille Nord de France, F-59000 Lille, France; USTL UMET UMR 8207 F-59655 Villeneuve d'Ascq, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Danède
authors.affiliation: Université Lille Nord de France, F-59000 Lille, France; USTL UMET UMR 8207 F-59655 Villeneuve d'Ascq, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Willart
authors.affiliation: Université Lille Nord de France, F-59000 Lille, France; USTL UMET UMR 8207 F-59655 Villeneuve d'Ascq, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Derollez
authors.affiliation: Université Lille Nord de France, F-59000 Lille, France; USTL UMET UMR 8207 F-59655 Villeneuve d'Ascq, France. Electronic address: alain.hedoux@univ-lille1.fr.
authors.forename: Alain
authors.initials: A
authors.lastname: Hédoux
mesh_terms: D002152:Calorimetry, Differential Scanning / Q000379:methods; D002220:Carbamazepine / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003460:Crystallization / Q000379:methods; D033362:Powder Diffraction / Q000379:methods; D011208:Powders / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D011208:Powders; D002220:Carbamazepine
keywords: Amorphous; Cryomilling; Crystallization; Low-wavenumber raman spectroscopy; Physical state