title: Does Longer Lifespan Mean Longer Healthspan?
abstract: Once thought to be impossible, it is now clear that changing the activity of several conserved genetic pathways can lead to lifespan extension in experimental organisms. In humans, however, the goal is to extend healthspan, the functional and disease-free period of life. Are the current pathways to lifespan extension also improving healthspan?
authors.affiliation: Sanford Burnham Prebys Medical Research Institute, La Jolla, CA 92037, USA. Electronic address: mhansen@sbpdiscovery.org.
authors.forename: Malene
authors.initials: M
authors.lastname: Hansen
authors.affiliation: Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: bkennedy@buckinstitute.org.
authors.forename: Brian K
authors.initials: BK
authors.lastname: Kennedy
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D006262:Health; D006801:Humans; D008136:Longevity / Q000187:drug effects / Q000502:physiology; D051379:Mice; D011972:Receptor, Insulin / Q000378:metabolism; D020123:Sirolimus / Q000494:pharmacology
chemical_list: D029742:Caenorhabditis elegans Proteins; C107483:DAF-2 protein, C elegans; D011972:Receptor, Insulin; D020123:Sirolimus
keywords: Caenorhabditis elegans; TOR signaling; aging; insulin/IGF-1 signaling; longevity; mice