title: Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy.
abstract: Proteotoxicity refers to toxic stress caused by misfolded proteins of extrinsic or intrinsic origin and plays an integral role in the pathogenesis of cardiovascular diseases. Herein, we provide an overview of the current understanding of mechanisms underlying proteotoxicity and its contribution in the pathogenesis of amyloid cardiomyopathy.
authors.affiliation: Departments of Medicine & Pharmacology, University of California San Diego, San Diego, California; and.
authors.forename: Valerie
authors.initials: V
authors.lastname: Sapp
authors.affiliation: Departments of Medicine & Pharmacology, University of California San Diego, San Diego, California; and.
authors.forename: Mohit
authors.initials: M
authors.lastname: Jain
authors.affiliation: Division of Genetics and Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Ronglih
authors.initials: R
authors.lastname: Liao
mesh_terms: D058227:Amyloidogenic Proteins / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D009202:Cardiomyopathies / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D057165:Proteostasis Deficiencies / Q000378:metabolism / Q000503:physiopathology*; D013312:Stress, Physiological
chemical_list: D058227:Amyloidogenic Proteins