title: Effects of resuscitation with polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and oxygen delivery in a rat model of hemorrhagic shock.
abstract: The objective of this study was to evaluate the effects of polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and oxygen delivery in a rat model of hemorrhagic shock. Rats underwent controlled hemorrhage, resulting in the loss of 65% of their blood volume in 90 minutes. The results showed that pPolyHb was superior to hetastarch and saline, and similar to whole blood, in restoring hemodynamic stability and reversing anaerobic metabolism caused by hemorrhage. Furthermore, pPolyHb improved oxygen supply and increased blood oxygen content. These data suggest that pPolyHb can be effective in improving tissue perfusion under conditions of severe hemorrhagic shock.
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: c The Reproductive Centre , Tangdu Hospital, The Forth Military Medical University , Xi'an , PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Kunping
authors.initials: K
authors.lastname: Yan
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Wencan
authors.initials: W
authors.lastname: Pan
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Xu
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Huifang
authors.initials: H
authors.lastname: Liu
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Chengbin
authors.initials: C
authors.lastname: Yan
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: a College of Life Science , Northwest University , Xi'an , PR China.|b National Engineering Research Center for Miniaturized Detection Systems , Northwest University , Xi'an , PR China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000494:pharmacology*; D004195:Disease Models, Animal; D006439:Hemodynamics / Q000187:drug effects*; D006454:Hemoglobins / Q000494:pharmacology*; D008297:Male; D010100:Oxygen / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012151:Resuscitation / Q000379:methods*; D012771:Shock, Hemorrhagic / Q000097:blood / Q000188:drug therapy; D013552:Swine
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; C037158:polyhemoglobin; D010100:Oxygen
keywords: hemodynamic stability; hemorrhagic shock; oxygen delivery; polymerized porcine hemoglobin (pPolyHb)