title: Review for Disease of the Year: Epidemiology of HLA-B27 Associated Ocular Disorders.
abstract: Acute anterior uveitis is generally recognized as the most common form of uveitis. An association with HLA-B27 is seen in approximately half of cases of acute anterior uveitis. The prevalence of HLA-B27 varies widely between ethnic populations, with an approximate 8-10% prevalence in non-Hispanic whites and lower prevalence in Mexican- (4%) and African- (2-4%) Americans. A group of systemic inflammatory diseases, the spondyloarthropathies, similarly demonstrates a strong association with HLA-B27. The strength of association varies, depending on the specific spondyloarthropathy, with the strongest association found in patients with ankylosing spondylitis. The majority of patients with HLA-B27 associated uveitis will have an underlying spondyloarthropathy. Suspicion for HLA-B27 associated uveitis should prompt a careful clinical history to assess for features of a spondyloarthropathy as the characteristics of any associated uveitis may vary.
authors.affiliation: a Casey Eye Institute, Oregon Health & Science University , Portland , Oregon , USA.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Kopplin
authors.affiliation: a Casey Eye Institute, Oregon Health & Science University , Portland , Oregon , USA.
authors.forename: George
authors.initials: G
authors.lastname: Mount
authors.affiliation: a Casey Eye Institute, Oregon Health & Science University , Portland , Oregon , USA.|b Portland Veterans Affairs Health Care System , Portland , Oregon , USA.
authors.forename: Eric B
authors.initials: EB
authors.lastname: Suhler
mesh_terms: D000208:Acute Disease; D005006:Ethnicity; D015796:HLA-B27 Antigen / Q000097:blood*; D006801:Humans; D015995:Prevalence; D025242:Spondylarthropathies / Q000453:epidemiology* / Q000276:immunology; D014606:Uveitis, Anterior / Q000453:epidemiology* / Q000276:immunology
chemical_list: D015796:HLA-B27 Antigen
keywords: Acute anterior uveitis; HLA-B27; epidemiology; iritis; spondyloarthropathy