title: Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging.
abstract: Plasma neuronal exosomal levels of pathogenic Alzheimer's disease (AD) proteins, cellular survival factors, and lysosomal proteins distinguish AD patients from control subjects, but changes in these exosomal proteins associated with normal aging have not been described for cognitively intact subjects. Plasma neuronal exosomal levels of P-T181-tau, P-S396-tau, Aβ 1-42, cathepsin D, repressor element 1-silencing transcription factor, and neurogranin were quantified longitudinally in cognitively intact older adults using two samples collected at 3- to 11-year intervals. Except for P-S396-tau, exosomal protein levels changed significantly with aging, but were largely outside the range observed in AD patients.
authors.affiliation: Sanders-Brown Center on Aging University of Kentucky Lexington Kentucky; Department of Epidemiology College of Public Health University of Kentucky Lexington Kentucky.
authors.forename: Erin L
authors.initials: EL
authors.lastname: Abner
authors.affiliation: Sanders-Brown Center on Aging University of Kentucky Lexington Kentucky; Department of Neurology College of Medicine University of Kentucky Lexington Kentucky.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Jicha
authors.affiliation: Department of Pathology University of Pennsylvania Philadelphia Pennsylvania.
authors.forename: Leslie M
authors.initials: LM
authors.lastname: Shaw
authors.affiliation: Department of Pathology University of Pennsylvania Philadelphia Pennsylvania; Center for Neurodegenerative Disease Research University of Pennsylvania Philadelphia Pennsylvania.
authors.forename: John Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.affiliation: Department of Medicine UCSF Medical Center and the Jewish Home of San Francisco San Francisco California.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Goetzl