title: Current views on anthracycline cardiotoxicity.
abstract: Anthracyclines are well established and effective anticancer agents used to treat a variety of adult and pediatric cancers. Unfortunately, these drugs are also among the commonest chemotherapeutic agents that have been recognized to cause cardiotoxicity. In the last years, several experimental and clinical investigations provided new information and perspectives on anthracycline-related cardiotoxicity. In particular, molecular mechanisms of cardiotoxicity have been better elucidated, early diagnosis has improved through the use of advanced noninvasive cardiac imaging techniques, and emerging data indicate a genetic predisposition to develop anthracycline-related cardiotoxicity. In this article, we review established and new knowledge about anthracycline cardiotoxicity, with special focus on recent advances in cardiotoxicity diagnosis and genetic profiling.
authors.affiliation: Cardiology Unit, Department of Cardiology and LTTA Centre, University Hospital of Ferrara, Ferrara, Italy. donatomele@libero.it.|Maria Cecilia Hospital, GVM Care and Research, E.S: Health Science Foundation, Cotignola, Italy. donatomele@libero.it.
authors.forename: Donato
authors.initials: D
authors.lastname: Mele
authors.affiliation: Cardiology Unit, Department of Cardiology and LTTA Centre, University Hospital of Ferrara, Ferrara, Italy.|Maria Cecilia Hospital, GVM Care and Research, E.S: Health Science Foundation, Cotignola, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Nardozza
authors.affiliation: Clinic of Cardiovascular Diseases, IRCCS San Martino IST, Genoa, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Spallarossa
authors.affiliation: Oncology Unit, University Hospital of Ferrara, Ferrara, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Frassoldati
authors.affiliation: Division of Internal Medicine, Department of Translational Medical Sciences, Federico II University, Naples, Italy.
authors.forename: Carlo G
authors.initials: CG
authors.lastname: Tocchetti
authors.affiliation: Department of Medical Sciences "Mario Aresu", University of Cagliari, Cagliari, Italy.
authors.forename: Christian
authors.initials: C
authors.lastname: Cadeddu
authors.affiliation: Department of Cardiology, Center of Excellence on Aging, "G. d'Annunzio" University, Chieti, Italy.
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Madonna
authors.affiliation: Cardiology Unit, Department of Cardiology and LTTA Centre, University Hospital of Ferrara, Ferrara, Italy.|Maria Cecilia Hospital, GVM Care and Research, E.S: Health Science Foundation, Cotignola, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Malagù
authors.affiliation: Cardiology Unit, Department of Cardiology and LTTA Centre, University Hospital of Ferrara, Ferrara, Italy.|Maria Cecilia Hospital, GVM Care and Research, E.S: Health Science Foundation, Cotignola, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Ferrari
authors.affiliation: Department of Medical Sciences "Mario Aresu", University of Cagliari, Cagliari, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mercuro
mesh_terms: D018943:Anthracyclines / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015415:Biomarkers; D066126:Cardiotoxicity / Q000000981:diagnostic imaging* / Q000235:genetics / Q000503:physiopathology*; D004452:Echocardiography; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D012307:Risk Factors
chemical_list: D018943:Anthracyclines; D000970:Antineoplastic Agents; D015415:Biomarkers
keywords: Anthracyclines; Cancer; Cardiotoxicity