title: Efficacy and safety of growth hormone treatment in children with short stature: the Italian cohort of the GeNeSIS clinical study.
abstract: OBJECTIVE
  We examined auxological changes in growth hormone (GH)-treated children in Italy using data from the Italian cohort of the multinational observational Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS) of pediatric patients requiring GH treatment.
  
  
  METHODS
  We studied 711 children (median baseline age 9.6 years). Diagnosis associated with short stature was as determined by the investigator. Height standard deviation score (SDS) was evaluated yearly until final or near-final height (n = 78). Adverse events were assessed in all GH-treated patients.
  
  
  RESULTS
  The diagnosis resulting in GH treatment was GH deficiency (GHD) in 85.5 % of patients, followed by Turner syndrome (TS 6.6 %). Median starting GH dose was higher in patients with TS (0.30 mg/kg/week) than patients with GHD (0.23 mg/kg/week). Median (interquartile range) GH treatment duration was 2.6 (0.6-3.7) years. Mean (95 % confidence interval) final height SDS gain was 2.00 (1.27-2.73) for patients with organic GHD (n = 18) and 1.19 (0.97-1.40) for patients with idiopathic GHD (n = 41), but lower for patients with TS, 0.37 (-0.03 to 0.77, n = 13). Final height SDS was >-2 for 94 % of organic GHD, 88 % of idiopathic GHD and 62 % of TS patients. Mean age at GH start was lower for organic GHD patients, and treatment duration was longer than for other groups, resulting in greater mean final height gain. GH-related adverse events occurred mainly in patients diagnosed with idiopathic GHD.
  
  
  CONCLUSIONS
  Data from the Italian cohort of GeNeSIS showed auxological changes and safety of GH therapy consistent with results from international surveillance databases.
authors.affiliation: Endocrinology and Diabetes Unit, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cappa
authors.affiliation: Pediatric Unit, University of Modena and Reggio, Modena, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Iughetti
authors.affiliation: Pediatric Endocrinology, Ospedale Microcitemico ASL Cagliari, Cagliari, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Loche
authors.affiliation: Department of Pediatrics, IRCCS Giannina Gaslini, University of Genova, Genoa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Maghnie
authors.affiliation: Medical Diabetes Group, Eli Lilly and Company, 50019, Sesto Fiorentino, Italy. vottero_alessandra@network.lilly.com.
authors.forename: A
authors.initials: A
authors.lastname: Vottero
mesh_terms: D000293:Adolescent; D001827:Body Height / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D004393:Dwarfism, Pituitary; D005260:Female; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007558:Italy; D008297:Male; D061214:Patient Safety; D011446:Prospective Studies; D016896:Treatment Outcome; D014424:Turner Syndrome / Q000188:drug therapy*
chemical_list: D019382:Human Growth Hormone
keywords: Final height; Growth; Pediatric GH treatment; Safety; Short stature