title: Role of DUSP1/MKP1 in tumorigenesis, tumor progression and therapy.
abstract: Dual-specificity phosphatase-1 (DUSP1/MKP1), as a member of the threonine-tyrosine dual-specificity phosphatase family, was first found in cultured murine cells. The molecular mechanisms of DUSP1-mediated extracellular signal-regulated protein kinases (ERKs) dephosphorylation have been subsequently identified by studies using gene knockout mice and gene silencing technology. As a protein phosphatase, DUSP1 also downregulates p38 MAPKs and JNKs signaling through directly dephosphorylating threonine and tyrosine. It has been detected that DUSP1 is involved in various functions, including proliferation, differentiation, and apoptosis in normal cells. In various human cancers, abnormal expression of DUSP1 was observed which was associated with prognosis of tumor patients. Further studies have revealed its role in tumorigenesis and tumor progression. Besides, DUSP1 has been found to play a role in tumor chemotherapy, immunotherapy, and biotherapy. In this review, we will focus on the function and mechanism of DUSP1 in tumor cells and tumor treatment.
authors.affiliation: Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
authors.forename: Jiliang
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Anesthesiology, Sir Run-Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Shen
authors.affiliation: Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
authors.forename: Yuelong
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
authors.forename: Renan
authors.initials: R
authors.lastname: Jin
authors.affiliation: Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
authors.forename: Xiujun
authors.initials: X
authors.lastname: Cai
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism*; D003131:Combined Modality Therapy; D018450:Disease Progression; D054638:Dual Specificity Phosphatase 1 / Q000235:genetics* / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D007167:Immunotherapy; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D015398:Signal Transduction / Q000187:drug effects / Q000528:radiation effects
chemical_list: D054638:Dual Specificity Phosphatase 1
keywords: Carcinogenesis; DUSP1/MKP1; JNK; tumor therapy