title: Cancer Treatment as an Accelerated Aging Process: Assessment, Biomarkers, and Interventions.
abstract: An accumulating body of evidence supports the hypothesis that cancer and/or cancer treatment is associated with accelerated aging. The majority of these data come from the pediatric literature; however, a smaller yet growing body of literature points toward similar findings in the geriatric population. This is a key survivorship issue the growing number of older adults with cancer face, along with the short- and long-term impact of cancer therapy on the aging process. This article will review clinical and biologic markers of aging in older adults with cancer, use cardiovascular disease as a model of accelerated aging, and discuss potential interventions to decrease the risk.
authors.affiliation: From the City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA; Memorial Sloan Kettering Cancer Center, New York, NY; The University of North Carolina at Chapel Hill, Chapel Hill, NC.
authors.forename: Arti
authors.initials: A
authors.lastname: Hurria
authors.affiliation: From the City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA; Memorial Sloan Kettering Cancer Center, New York, NY; The University of North Carolina at Chapel Hill, Chapel Hill, NC.
authors.forename: Lee
authors.initials: L
authors.lastname: Jones
authors.affiliation: From the City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, CA; Memorial Sloan Kettering Cancer Center, New York, NY; The University of North Carolina at Chapel Hill, Chapel Hill, NC.
authors.forename: Hyman B
authors.initials: HB
authors.lastname: Muss
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000187:drug effects / Q000473:pathology*; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000503:physiopathology*; D015577:Geriatric Assessment; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D017741:Survivors
chemical_list: D015415:Biomarkers