title: Controlled and Sequential Delivery of Fluorophores from 3D Printed Alginate-PLGA Tubes.
abstract: Controlled drug delivery systems, that include sequential and/or sustained drug delivery, have been utilized to enhance the therapeutic effects of many current drugs by effectively delivering drugs in a time-dependent and repeatable manner. In this study, with the aid of 3D printing technology, a novel drug delivery device was fabricated and tested to evaluate sequential delivery functionality. With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney (HEK293) cell line or bone marrow stromal stem cells (BMSC). The controlled differential release of drugs or proteins through such a delivery system has the potential to be used in a wide variety of biomedical applications from treating cancer to regenerative medicine.
authors.affiliation: Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa, IA, USA.|Department of Chemical and Biochemical Engineering, College of Engineering, University of Iowa, Iowa, IA, USA.
authors.forename: Anh-Vu
authors.initials: AV
authors.lastname: Do
authors.affiliation: Center for Computer-Aided Design, College of Engineering, University of Iowa, Iowa, IA, USA.
authors.forename: Adil
authors.initials: A
authors.lastname: Akkouch
authors.affiliation: Department of Chemical and Biochemical Engineering, College of Engineering, University of Iowa, Iowa, IA, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Green
authors.affiliation: Center for Computer-Aided Design, College of Engineering, University of Iowa, Iowa, IA, USA.|Department of Engineering Science and Mechanics, Penn State University, State College, PA, USA.|The Huck Institutes of the Life Sciences, Penn State University, State College, PA, USA.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ozbolat
authors.affiliation: Center for Computer-Aided Design, College of Engineering, University of Iowa, Iowa, IA, USA.
authors.forename: Amer
authors.initials: A
authors.lastname: Debabneh
authors.affiliation: Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa, IA, USA.
authors.forename: Sean
authors.initials: S
authors.lastname: Geary
authors.affiliation: Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa, IA, USA. aliasger-salem@uiowa.edu.|Department of Chemical and Biochemical Engineering, College of Engineering, University of Iowa, Iowa, IA, USA. aliasger-salem@uiowa.edu.
authors.forename: Aliasger K
authors.initials: AK
authors.lastname: Salem
mesh_terms: D000464:Alginates / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D005456:Fluorescent Dyes / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D020723:Glucuronic Acid / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D057809:HEK293 Cells; D006603:Hexuronic Acids / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011100:Polyglycolic Acid / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D066330:Printing, Three-Dimensional
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D005456:Fluorescent Dyes; D006603:Hexuronic Acids; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D020723:Glucuronic Acid
keywords: Alginate; Composite materials; Controlled delivery; Differential delivery; Extrusion printing; PLGA