title: Hyperuricemia, Cardiovascular Profile, and Comorbidity in Older Men and Women: The Pro.V.A. Study.
abstract: Hyperuricemia (HU) is growing worldwide and associates with several medical conditions in the elderly. However, data about older people and possible gender differences are sparse. The aim of this study was to compare HU prevalence rates and association with relevant medical disorders in elderly subjects of both sexes. Pro.V.A. is a survey of 3099 individuals aged 65+, focusing on chronic diseases and disability. Uric acid (UA) levels were dichotomized using 6.0 mg/dL (females) and 7.0 mg/dL (males), and multivariate logistic regression models were used to estimate odds ratios (ORs) between HU and single comorbidity. HU prevalence was 21.5% in females and 15.8% in males. HU was associated with most anthropometric and laboratory variables in women, but not in men. After adjustment for age, body mass index, and renal function, HU was independently associated with the presence of cardiovascular diseases in both sexes. In women, HU was associated with hand osteoarthritis (OR = 1.52; 95%CI: 1.12-2.08) and edentulism (OR = 1.31; 95%CI: 1.01-1.71), while resulted protective for osteoporosis (OR = 0.69; 95%CI: 0.53-0.91). In men, HU was significantly related with knee osteoarthritis (OR = 1.72; 95%CI: 1.06-2.79) and chronic obstructive pulmonary disease (OR = 1.60; 95%CI: 1.04-2.45). The presence of ≥4 comorbidities was a stronger determinant of HU in men (OR = 2.54; 95%CI: 1.21-5.37) than in women (ns). Patterns of age-dependent UA increase are markedly different in men and women. HU prevalence is substantial and its association with other diseases is gender specific, connoting a peculiar clinical profile.
authors.affiliation: 1 Department of Medicine DIMED, Clinica Medica 1, University of Padova , Padova, Italy .
authors.forename: Estella
authors.initials: E
authors.lastname: Musacchio
authors.affiliation: 2 Department of Cardiologic, Thoracic and Vascular Sciences, Unit of Biostatistics, Epidemiology and Public Health, University of Padova , Padova, Italy .
authors.forename: Egle
authors.initials: E
authors.lastname: Perissinotto
authors.affiliation: 1 Department of Medicine DIMED, Clinica Medica 1, University of Padova , Padova, Italy .
authors.forename: Leonardo
authors.initials: L
authors.lastname: Sartori
authors.affiliation: 3 Department of Medicine DIMED, Geriatric Unit, University of Padova , Padova, Italy .
authors.forename: Nicola
authors.initials: N
authors.lastname: Veronese
authors.affiliation: 4 Department of Medicine DIMED, Rheumatology Unit, University of Padova , Padova, Italy .
authors.forename: Leonardo
authors.initials: L
authors.lastname: Punzi
authors.affiliation: 1 Department of Medicine DIMED, Clinica Medica 1, University of Padova , Padova, Italy .
authors.forename: Sabina
authors.initials: S
authors.lastname: Zambon
authors.affiliation: 3 Department of Medicine DIMED, Geriatric Unit, University of Padova , Padova, Italy .|5 National Research Council, Aging Branch, Institute of Neuroscience , Padova, Italy .
authors.forename: Enzo
authors.initials: E
authors.lastname: Manzato
authors.affiliation: 6 Department of Molecular Medicine DMM, University of Padova , Padova, Italy .
authors.forename: Giovannella
authors.initials: G
authors.lastname: Baggio
authors.affiliation: 7 Department of Public Health, Regione Veneto , Venezia, Italy .
authors.forename: Maria-Chiara
authors.initials: MC
authors.lastname: Corti
authors.affiliation: 5 National Research Council, Aging Branch, Institute of Neuroscience , Padova, Italy .
authors.forename: Gaetano
authors.initials: G
authors.lastname: Crepaldi
authors.affiliation: 4 Department of Medicine DIMED, Rheumatology Unit, University of Padova , Padova, Italy .
authors.forename: Roberta
authors.initials: R
authors.lastname: Ramonda
mesh_terms: D000368:Aged; D000886:Anthropometry; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000453:epidemiology*; D007558:Italy / Q000453:epidemiology; D008019:Life Style; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D015995:Prevalence; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid
keywords: cardiovascular disease; comorbidity; elderly; epidemiology; hyperuricemia; uric acid