title: Thermal [2 + 2]-Cycloaddition of Ketenes with Chiral Enol Ethers: Route to Densely Substituted Cyclobutanones.
abstract: Access to chiral polysubstituted cyclobutanones by [2 + 2]-cycloaddition of ketenes with chiral acyclic enol ethers is reported. A wide variety of easily accessible di- and monosubstituted ketenes were found to react with a very high degree of stereoselectivity with chiral, Stericol derived, acyclic enol ethers. This combination of simple reagents provides straightforward entry to highly substituted enantioenriched cyclobutanones.
authors.affiliation: Univ. Grenoble Alpes, DCM , F-38000 Grenoble, France.|CNRS, DCM , F-38000 Grenoble, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Rullière
authors.affiliation: Univ. Grenoble Alpes, DCM , F-38000 Grenoble, France.|CNRS, DCM , F-38000 Grenoble, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Grisel
authors.affiliation: Univ. Grenoble Alpes, DCM , F-38000 Grenoble, France.|CNRS, DCM , F-38000 Grenoble, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Poittevin
authors.affiliation: Univ. Grenoble Alpes, DCM , F-38000 Grenoble, France.|CNRS, DCM , F-38000 Grenoble, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Cividino
authors.affiliation: Univ. Grenoble Alpes, DCM , F-38000 Grenoble, France.|CNRS, DCM , F-38000 Grenoble, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Carret
authors.affiliation: Univ. Grenoble Alpes, DCM , F-38000 Grenoble, France.|CNRS, DCM , F-38000 Grenoble, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Poisson