title: The influence of skin microorganisms on cutaneous immunity.
abstract: The skin is a complex and dynamic ecosystem that is inhabited by many microorganisms. Recent evidence highlights the profound reliance of the skin immune system on its resident microbiota for both host defence and tissue repair. This tissue is also a primary target for infections, which are in some cases caused by normal constituents of the microbiota. In the context of infections and genetic predispositions that are associated with barrier or regulatory network defects, microorganism-induced inflammatory cycles can contribute to the initiation and/or amplification of skin disorders. This Review will discuss some of our current understanding of skin-microbiota and skin-pathogen interactions in the context of homeostasis and diseases and highlight current gaps in our understanding of the skin immune ecosystem.
authors.affiliation: National Institute of Allergy and Infectious diseases (NIAID) Microbiome Program, US National Institutes of Health (NIH), Bethesda, Maryland 20892, USA.|Mucosal Immunology Section, Laboratory of Parasitic Diseases, NIAID, US NIH, Bethesda, Maryland 20892, USA.
authors.forename: Yasmine
authors.initials: Y
authors.lastname: Belkaid
authors.affiliation: Mucosal Immunology Section, Laboratory of Parasitic Diseases, NIAID, US NIH, Bethesda, Maryland 20892, USA.
authors.forename: Samira
authors.initials: S
authors.lastname: Tamoutounour
mesh_terms: D000818:Animals; D004198:Disease Susceptibility; D006706:Homeostasis; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D007109:Immunity; D056747:Immunomodulation; D064307:Microbiota; D012867:Skin / Q000276:immunology* / Q000382:microbiology*; D012871:Skin Diseases / Q000209:etiology / Q000378:metabolism