title: An array of individually addressable micro-needles for mapping pH distributions.
abstract: This work describes the preparation of an array of individually addressable pH sensitive microneedles which are sensitized by electrodepositing iridium oxide. The impact of the deposition potential, storage conditions and interferents on the sensor characteristics such as slope, offset, intra- and inter-batch reproducibility is investigated. The device may be a useful tool for carrying out direct pH measurements of soft and heterogeneous samples such as tissues and organs. For example, we demonstrated that the microneedle array can be employed for real-time mapping of the cardiac pH distribution during cycles of global ischemia and reperfusion.
authors.affiliation: Centre for Bioinspired Technology, Electrical and Electronic Engineering Department, Imperial College London, South Kensington, London, UK. c.zuliani@imperial.ac.uk.
authors.forename: Claudio
authors.initials: C
authors.lastname: Zuliani
authors.affiliation: National Heart & Lung Institute, Imperial College London, London, UK.
authors.forename: Fu Siong
authors.initials: FS
authors.lastname: Ng
authors.affiliation: Centre for Bioinspired Technology, Electrical and Electronic Engineering Department, Imperial College London, South Kensington, London, UK. c.zuliani@imperial.ac.uk.
authors.forename: Andrea
authors.initials: A
authors.lastname: Alenda
authors.affiliation: Centre for Bioinspired Technology, Electrical and Electronic Engineering Department, Imperial College London, South Kensington, London, UK. c.zuliani@imperial.ac.uk.
authors.forename: Amir
authors.initials: A
authors.lastname: Eftekhar
authors.affiliation: National Heart & Lung Institute, Imperial College London, London, UK.
authors.forename: Nicholas S
authors.initials: NS
authors.lastname: Peters
authors.affiliation: Centre for Bioinspired Technology, Electrical and Electronic Engineering Department, Imperial College London, South Kensington, London, UK. c.zuliani@imperial.ac.uk.
authors.forename: Christofer
authors.initials: C
authors.lastname: Toumazou