title: Three new alkaloids from the seeds of Nigella glandulifera.
abstract: Three new alkaloids namely 8-(4-hydroxyphenyl)-6-methoxy-3,4-dihydroisoquinolin-1(2H)-one (1), 4-aminonigellidine (2), and N-[(4-hydroxy-2-isopropyl-5-methyl)]phenylurea (3), along with six known ones (4-9), were isolated from the seeds of Nigella glandulifera. The structures of 1-3 were determined through spectroscopic analyses (HRESIMS, 1D/2D NMR). Compound 1 was a rare isoquinolinone alkaloid with phenyl substituted at C-8.
authors.affiliation: a State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing 210009 , China.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Guo
authors.affiliation: a State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing 210009 , China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing 210009 , China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Huang
authors.affiliation: a State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing 210009 , China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Yang
authors.affiliation: a State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing 210009 , China.
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D007191:Indazoles; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D031844:Nigella / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010671:Phenylurea Compounds / Q000737:chemistry / Q000302:isolation & purification*; D012639:Seeds / Q000737:chemistry*
chemical_list: C000608288:3,4-dihydroisoquinolin-1(2H)-one; C000613940:4-aminonigellidine; C000613939:8-(4-hydroxyphenyl)-6-methoxy-3,4-dihydroisoquinolin-1(2H)-one; D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D007191:Indazoles; D007546:Isoquinolines; C000613941:N-((4-hydroxy-2-isopropyl-5-methyl))phenylurea; D010671:Phenylurea Compounds
keywords: Nigella glandulifera; Ranunculaceae; Semen Nigellae; alkaloids