title: Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy.
abstract: Accumulation of nanoparticles in solid tumors depends on their extravasation, but their efficacy is often compromised by intrinsic physiological heterogeneity in tumors. The conventional solutions to circumvent this problem are size control of nanoparticles or increasing the vascular permeability. The aim of this study is to investigate the combination effect of size variation of stimuli-responsive nanoparticles and improved vascular permeability triggered by near-infrared (NIR) light irradiation. Doxorubicin (DOX), a clinically proven drug for bladder cancer, was encapsulated in the nanocomposites with high loading content up to 45%. We show that NIR light-responsive size-switchable nanocarriers could considerably enhance the tumor-targeting of DOX in bladder tumor-bearing mice. Moreover, a combination of NIR-induced hyperthermia and DOX-mediated chemotherapy resulted in remarkable inhibition of tumor growth in mice. Histological results suggest that the change in morphology of tumor microvasculature may account for enhanced extravasation and accumulation of the nanodrugs upon NIR irradiation. Together, these data suggest that external stimuli-responsive drug delivery system offers a safe and effective means of targeted chemo/photothermal therapy.
authors.affiliation: Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Laboratory Medicine and Life Science, Wenzhou Medical University , Wenzhou 325035, Zhejiang Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
authors.affiliation: Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Laboratory Medicine and Life Science, Wenzhou Medical University , Wenzhou 325035, Zhejiang Province, China.|CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Bi
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Laboratory Medicine and Life Science, Wenzhou Medical University , Wenzhou 325035, Zhejiang Province, China.
authors.forename: Lirong
authors.initials: L
authors.lastname: Peng
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Kaikai
authors.initials: K
authors.lastname: Wen
authors.affiliation: Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Laboratory Medicine and Life Science, Wenzhou Medical University , Wenzhou 325035, Zhejiang Province, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Ji
authors.affiliation: Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Laboratory Medicine and Life Science, Wenzhou Medical University , Wenzhou 325035, Zhejiang Province, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Ren
authors.affiliation: Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Laboratory Medicine and Life Science, Wenzhou Medical University , Wenzhou 325035, Zhejiang Province, China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Li
authors.affiliation: Research Center of Basic Medical Sciences & Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Medical University , Tianjin 300070, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Laboratory Medicine and Life Science, Wenzhou Medical University , Wenzhou 325035, Zhejiang Province, China.
authors.forename: Jimin
authors.initials: J
authors.lastname: Gao
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100049, China.|School of Radiological and Interdisciplinary Sciences, Soochow University , Suzhou 215123, China.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Chai
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100049, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D006979:Hyperthermia, Induced; D007259:Infrared Rays; D051379:Mice; D058990:Molecular Targeted Therapy / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects*; D009369:Neoplasms / Q000188:drug therapy*; D010789:Phototherapy / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin
keywords: chemo/photothermal therapy; nanoparticles; size-switchable; stimuli-responsive; vascular permeability