title: Effect of Aspirin Supplementation on Hemostatic Responses in Firefighters Aged 40 to 60 Years.
abstract: Sudden cardiovascular events account for approximately 45% to 50% of all duty-related deaths among firefighters and a disproportionate number of these fatalities occur after strenuous fire suppression activities. The purpose of this study was to evaluate the effect of acute and chronic aspirin supplementation on hemostatic function before and after live firefighting activities in older firefighters. A double-blind, crossover design included 4 treatments: a 2-week aspirin/placebo treatment ("chronic") and a single prefirefighting aspirin/placebo treatment ("acute"). Hemostatic function was assessed in 24 male firefighters (mean age = 48.2 ± 5.9 years) immediately before and after 18 minutes of live-fire firefighting activity. An acute bout of firefighting activity significantly decreased platelet aggregation time and decreased activated partial thromboplastin time. Compared with placebo, acute aspirin supplementation resulted in a significant increase in epinephrine closure time, which was further augmented by chronic supplementation. Aspirin supplementation had no effect on coagulatory or fibrinolytic factors. Our findings suggest that an acute bout of firefighting leads to increased coagulatory potential in older firefighters. In conclusion, aspirin supplementation had an antiplatelet effect that decreased platelet aggregability at rest and after an acute bout of firefighting compared with placebo.
authors.affiliation: Illinois Fire Service Institute, University of Illinois at Urbana-Champaign, Champaign, Illinois; Department of Health and Exercise Sciences, Skidmore College, Saratoga Springs, New York. Electronic address: dsmith@skidmore.edu.
authors.forename: Denise L
authors.initials: DL
authors.lastname: Smith
authors.affiliation: Illinois Fire Service Institute, University of Illinois at Urbana-Champaign, Champaign, Illinois.
authors.forename: Gavin P
authors.initials: GP
authors.lastname: Horn
authors.affiliation: Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Woods
authors.affiliation: Division of Space Life Sciences, Universities Space Research Association, Houston, Texas.
authors.forename: Robert
authors.initials: R
authors.lastname: Ploutz-Snyder
authors.affiliation: Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois.
authors.forename: Bo
authors.initials: B
authors.lastname: Fernhall
mesh_terms: D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000517:prevention & control; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004837:Epinephrine; D005342:Fibrinolysis / Q000187:drug effects; D061388:Firefighters; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D005082:Physical Exertion; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin; D004837:Epinephrine