title: Increased circulating cell-derived microparticle count is associated with recurrent implantation failure after IVF and embryo transfer.
abstract: Cell-derived microparticles (cMPs) are small membrane vesicles that are released from many different cell types in response to cellular activation or apoptosis. Elevated cMP counts have been found in almost all thrombotic diseases and pregnancy wastage, such as recurrent spontaneous abortion and in a number of conditions associated with inflammation, cellular activation and angiogenesis. cMP count was investigated in patients experiencing unexplained recurrent implantation failure (RIF). The study group was composed of 30 women diagnosed with RIF (RIF group). The first control group (IVF group) (n = 30) comprised patients undergoing a first successful IVF cycle. The second control group (FER group) included 30 healthy women who had at least one child born at term and no history of infertility or obstetric complications. cMP count was significantly higher in the RIF group compared with the IVF and FER groups (P < 0.05 and P < 0.01, respectively) (RIF group: 15.8 ± 6.2 nM phosphatidylserine equivalent [PS eq]; IVF group: 10.9 ± 5.3 nM PS eq; FER group: 9.6 ± 4.0 nM PS eq). No statistical difference was found in cMP count between the IVF and FER groups. Increased cMP count is, therefore, associated with RIF after IVF and embryo transfer.
authors.affiliation: Institut Clínic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine - University of Barcelona, Hospital Clínic of Barcelona, Villarroel Street, 170, Barcelona 08036, Spain.
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Martínez-Zamora
authors.affiliation: Hemotherapy and Hemostasis Unit, Faculty of Medicine - University of Barcelona, Hospital Clínic of Barcelona, Villarroel Street, 170, Barcelona 08036, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Dolors
authors.initials: D
authors.lastname: Tàssies
authors.affiliation: Hemotherapy and Hemostasis Unit, Faculty of Medicine - University of Barcelona, Hospital Clínic of Barcelona, Villarroel Street, 170, Barcelona 08036, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Reverter
authors.affiliation: Institut Clínic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine - University of Barcelona, Hospital Clínic of Barcelona, Villarroel Street, 170, Barcelona 08036, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Creus
authors.affiliation: Institut Clínic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine - University of Barcelona, Hospital Clínic of Barcelona, Villarroel Street, 170, Barcelona 08036, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Casals
authors.affiliation: Institut Clínic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine - University of Barcelona, Hospital Clínic of Barcelona, Villarroel Street, 170, Barcelona 08036, Spain.
authors.forename: Salvadora
authors.initials: S
authors.lastname: Cívico
authors.affiliation: Institut Clínic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine - University of Barcelona, Hospital Clínic of Barcelona, Villarroel Street, 170, Barcelona 08036, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Carmona
authors.affiliation: Institut Clínic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine - University of Barcelona, Hospital Clínic of Barcelona, Villarroel Street, 170, Barcelona 08036, Spain. Electronic address: jbalasch@ub.edu.
authors.forename: Juan
authors.initials: J
authors.lastname: Balasch
mesh_terms: D000026:Abortion, Habitual; D000022:Abortion, Spontaneous / Q000175:diagnosis; D000328:Adult; D017209:Apoptosis; D016022:Case-Control Studies; D055252:Cell-Derived Microparticles; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D007249:Inflammation; D009774:Obstetrics; D010718:Phosphatidylserines / Q000737:chemistry; D011247:Pregnancy; D011446:Prospective Studies; D012008:Recurrence; D012189:Retrospective Studies; D013927:Thrombosis
chemical_list: D010718:Phosphatidylserines
keywords: cell-derived microparticles; microparticles; recurrent implantation failure; recurrent reproductive failure