title: Synthesis and self-assembly of DNA-chromophore hybrid amphiphiles.
abstract: DNA based spherical nanostructures are one of the promising nanostructures for several biomedical and biotechnological applications due to their excellent biocompatibility and DNA-directed surface addressability. Herein, we report the synthesis and amphiphilicity-driven self-assembly of two classes of DNA (hydrophilic)-chromophore (hydrophobic) hybrid amphiphiles into spherical nanostructures. A solid-phase "click" chemistry based modular approach is demonstrated for the synthesis of DNA-chromophore amphiphiles. Various spectroscopic and microscopic analyses reveal the self-assembly of the amphiphiles into vesicular and micellar assemblies with the corona made of hydrophilic DNA and the hydrophobic chromophoric unit as the core of the spherical nanostructures.
authors.affiliation: School of Chemistry, Indian Institute of Science Education and Research-Thiruvananthapuram (IISER-TVM), CET campus, Trivandrum-695016, India. reji@iisertvm.ac.in.
authors.forename: Shine K
authors.initials: SK
authors.lastname: Albert
authors.forename: Murali
authors.initials: M
authors.lastname: Golla
authors.forename: Hari Veera Prasad
authors.initials: HV
authors.lastname: Thelu
authors.forename: Nithiyanandan
authors.initials: N
authors.lastname: Krishnan
authors.forename: Perapaka
authors.initials: P
authors.lastname: Deepak
authors.forename: Reji
authors.initials: R
authors.lastname: Varghese
mesh_terms: D001578:Benzopyrans / Q000737:chemistry*; D057930:Click Chemistry; D004247:DNA / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007211:Indoles / Q000737:chemistry*; D008823:Micelles; D049329:Nanostructures / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001578:Benzopyrans; D007211:Indoles; D008823:Micelles; D011166:Porphyrins; D013501:Surface-Active Agents; C548873:merocyanine; D004247:DNA