title: Comparison of high-intensity vs. high-volume resistance training on the BDNF response to exercise.
abstract: This study compared the acute and chronic response of circulating plasma brain-derived neurotrophic factor (BDNF) to high-intensity low-volume (HI) and low-intensity high volume (HV) resistance training. Twenty experienced resistance-trained men (23.5 ± 2.6 y, 1.79 ± 0.05 m, 75.7 ± 13.8 kg) volunteered for this study. Before the resistance training program (PRE), participants performed an acute bout of exercise using either the HI [3-5 reps; 90% of one repetition maximum (1RM)] or HV (10-12 reps; 70% 1RM) training paradigm. The acute exercise protocol was repeated after 7 wk of training (POST). Blood samples were obtained at rest (BL), immediately (IP), 30 min (30P), and 60 min (60P) post exercise at PRE and POST. A three-way repeated measure ANOVA was used to analyze acute changes in BDNF concentrations during HI and HV resistance exercise and the effect of 7 wk of training. No training × time × group interaction in BDNF was noted (P = 0.994). Significant main effects for training (P = 0.050) and time (P < 0.001) in BDNF were observed. Significant elevations in BDNF concentrations were seen from BL at IP (P = 0.001), 30P (P < 0.001), and 60P (P < 0.001) in both HI and HV combined during PRE and POST. BDNF concentrations were also observed to increase from PRE to POST when collapsed across groups and time. No significant group × training interaction (P = 0.342), training (P = 0.105), or group (P = 0.238) effect were noted in the BDNF area under the curve response. Results indicate that BDNF concentrations are increased after an acute bout of resistance exercise, regardless of training paradigm, and are further increased during a 7-wk training program in experienced lifters.
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, Florida;
authors.forename: David D
authors.initials: DD
authors.lastname: Church
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, Florida; jay.hoffman@ucf.edu.
authors.forename: Jay R
authors.initials: JR
authors.lastname: Hoffman
authors.affiliation: Department of Exercise Science and Sport Management, Kennesaw State University, Kennesaw, Georgia; and.
authors.forename: Gerald T
authors.initials: GT
authors.lastname: Mangine
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, Florida;
authors.forename: Adam R
authors.initials: AR
authors.lastname: Jajtner
authors.affiliation: Exercise and Nutrition Science, Lipscomb University, Nashville, Tennessee.
authors.forename: Jeremy R
authors.initials: JR
authors.lastname: Townsend
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, Florida;
authors.forename: Kyle S
authors.initials: KS
authors.lastname: Beyer
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, Florida;
authors.forename: Ran
authors.initials: R
authors.lastname: Wang
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, Florida;
authors.forename: Michael B
authors.initials: MB
authors.lastname: La Monica
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, Florida;
authors.forename: David H
authors.initials: DH
authors.lastname: Fukuda
authors.affiliation: Institute of Exercise Physiology and Wellness, Sport and Exercise Science, University of Central Florida, Orlando, Florida;
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Stout
mesh_terms: D000368:Aged; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D055070:Resistance Training / Q000379:methods; D012146:Rest / Q000502:physiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: muscle; neurotrophin; resistance exercise; training status