title: Interaction of vitamin E isoforms on asthma and allergic airway disease.
abstract: Prospective epidemiological studies, observational cross-sectional studies and some randomised prevention trials have demonstrated inconsistent findings of the impact of vitamin E on asthma risk. The goals of this study were to explore whether this differing association of vitamin E on asthma risk is due to an interaction of vitamin E isoforms. To address this question, in a population-based asthma incidence study we assessed the interaction between the plasma concentrations of vitamin E isoforms α-tocopherol and γ-tocopherol on asthma risk. Second, to understand the mechanisms of any interaction of these isoforms, we conducted experimental supplementation of α-tocopherol and γ-tocopherol isoforms in mice on the outcome of allergic airway inflammation. We found that in the highest γ-tocopherol tertile, low levels of α-tocopherol were associated with increased asthma risk, while highest tertile α-tocopherol levels trended to be protective. Similarly, in a mouse model of asthma, diet supplementation with α-tocopherol decreased lung inflammation in response to house dust mite (HDM) challenge. In contrast, diet supplementation with γ-tocopherol increased lung inflammation in response to HDM. These human and animal studies provide evidence for the competing effects of the vitamin E isoforms, in physiological concentrations, on asthma and allergic airway disease.
authors.affiliation: Northwestern University, Chicago, Illinois, USA.
authors.forename: Joan
authors.initials: J
authors.lastname: Cook-Mills
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: Tebeb
authors.initials: T
authors.lastname: Gebretsadik
authors.affiliation: Northwestern University, Chicago, Illinois, USA.
authors.forename: Hiam
authors.initials: H
authors.lastname: Abdala-Valencia
authors.affiliation: Northwestern University, Chicago, Illinois, USA.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Green
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: Emma K
authors.initials: EK
authors.lastname: Larkin
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: William D
authors.initials: WD
authors.lastname: Dupont
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: Xiao Ou
authors.initials: XO
authors.lastname: Shu
authors.affiliation: Department of Laboratory Medicine and Pathology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Myron
authors.initials: M
authors.lastname: Gross
authors.affiliation: Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Chunxue
authors.initials: C
authors.lastname: Bai
authors.affiliation: Department of Epidemiology, Shanghai Cancer Institute, Shanghai, People's Republic of China.
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.affiliation: Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
authors.forename: Terryl J
authors.initials: TJ
authors.lastname: Hartman
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Rosas-Salazar
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: Tina
authors.initials: T
authors.lastname: Hartert
mesh_terms: D000818:Animals; D001249:Asthma / Q000097:blood*; D006801:Humans; D051379:Mice; D020033:Protein Isoforms / Q000097:blood; D012130:Respiratory Hypersensitivity / Q000097:blood; D024502:alpha-Tocopherol / Q000097:blood*; D024504:gamma-Tocopherol / Q000097:blood*
chemical_list: D020033:Protein Isoforms; D024504:gamma-Tocopherol; D024502:alpha-Tocopherol
keywords: Allergic lung disease; Asthma; Asthma Epidemiology; Asthma Mechanisms