title: Bone augmentation around a dental implant using demineralized bone sheet containing biologically active substances.
abstract: This study was designed to evaluate the volume of alveolar bone augmentation after immediate implant placement using demineralized bone. We examined the collagen matrix of demineralized bone and biologically active substances contained therein. Rat maxillary first molars were extracted, and the animals were divided into five groups as follows: tooth extraction only, implant into the mesial root socket, implant and other root sockets covered with demineralized bone sheet, implant and other root sockets filled with demineralized bone powder under the sheet, and implant and other root sockets covered with demineralized bone sheet from which proteins were extracted. We ascertained whether biologically active substances are contained in extracted proteins. Biologically active substances were detected in extracted proteins. Conditions using demineralized bone sheet with biologically active substances significantly augmented the height of the alveolar bone. Such resorbable membranes containing biologically active substances hold promise as clinical agents for bone augmentation upon implantation.
authors.affiliation: Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine.
authors.forename: Mai
authors.initials: M
authors.lastname: Shirai
authors.forename: Ryuji
authors.initials: R
authors.lastname: Yamamoto
authors.forename: Toshie
authors.initials: T
authors.lastname: Chiba
authors.forename: Koichiro
authors.initials: K
authors.lastname: Komatsu
authors.forename: Shinji
authors.initials: S
authors.lastname: Shimoda
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yamakoshi
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Oida
authors.forename: Chikahiro
authors.initials: C
authors.lastname: Ohkubo
mesh_terms: D000539:Alveolar Process; D000540:Alveolar Ridge Augmentation; D000818:Animals; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D051381:Rats; D020390:Tooth Socket / Q000601:surgery
chemical_list: D015921:Dental Implants