title: Autoimmune encephalitis mimicking sporadic Creutzfeldt-Jakob disease: A retrospective study.
abstract: Autoimmune encephalitis associated with anti-voltage-gated potassium channel antibodies are most likely to be misdiagnosed as sporadic Creutzfeldt-Jakob disease (sCJD). Our goal was to delineate patients who were initially suspected to have CJD but were later found to have AE. We performed a retrospective clinical review of cases of individuals and made a comparison between groups of patients diagnosed with sCJD and AE. Patients who had rapidly progressing dementia and focal neurological impairment, such as aphasia, gait disturbance, visual disturbance, and depression, at onset were diagnosed with sCJD, whereas epilepsy, hyponatremia and dysautonomia were strong hints for AE. Fluoroscope-positron emission tomography (PET) of patients with AE revealed variable metabolism and normative and long-term immunosuppression were less likely to relapse.
authors.affiliation: Department of Neurology, General Hospital of People's Liberation Army, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. Electronic address: alive152043@126.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurology, General Hospital of People's Liberation Army, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. Electronic address: xingxw2000@126.com.
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Xing
authors.affiliation: Department of Neurology, General Hospital of People's Liberation Army, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. Electronic address: Edwin-zhang@263.net.
authors.forename: Jia-Tang
authors.initials: JT
authors.lastname: Zhang
authors.affiliation: Department of Neurology, General Hospital of People's Liberation Army, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. Electronic address: ruoxi890314@sina.com.
authors.forename: Ruo-Xi
authors.initials: RX
authors.lastname: Wang
authors.affiliation: Department of Neurology, General Hospital of People's Liberation Army, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. Electronic address: zw_sunshine@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Neurology, General Hospital of People's Liberation Army, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. Electronic address: dtanqc@163.com.
authors.forename: Qing-Che
authors.initials: QC
authors.lastname: Tan
authors.affiliation: Department of Neurology, General Hospital of People's Liberation Army, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. Electronic address: liurz301@163.com.
authors.forename: Ruo-Zhuo
authors.initials: RZ
authors.lastname: Liu
authors.affiliation: Department of Neurology, General Hospital of People's Liberation Army, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. Electronic address: bjxqwang13@163.com.
authors.forename: Xiang-Qing
authors.initials: XQ
authors.lastname: Wang
authors.affiliation: Department of Neurology, General Hospital of People's Liberation Army, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. Electronic address: lewish301@126.com.
authors.forename: Xu-Sheng
authors.initials: XS
authors.lastname: Huang
authors.affiliation: Department of Neurology, General Hospital of People's Liberation Army, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. Electronic address: yusy1963@126.com.
authors.forename: Sheng-Yuan
authors.initials: SY
authors.lastname: Yu
mesh_terms: D000368:Aged; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology*; D003937:Diagnosis, Differential; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008565:Membrane Proteins / Q000276:immunology / Q000378:metabolism; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology / Q000378:metabolism; D016884:Polyendocrinopathies, Autoimmune / Q000175:diagnosis* / Q000503:physiopathology; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: C403049:CNTNAP2 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins
keywords: Cerebral PET; Immunotherapy; Myoclonus; VGKC autoimmune encephalitis