title: [About a case of a recurrent glandular cardiac myxoma in a child].
abstract: Primary cardiac tumors are extremely rare and mainly benign. The majority of these are myxomas (40%). Myxoma are generally sporadic tumors which occur most commonly in adult females between 30 and 40 years, and are seldom found in the paediatric population (5%). Seven percent are associated with igenetic diseases. We report the case of an eight-year-old boy presenting a recurrent glandular cardiac myxoma. In 2011, he presented a deterioration of the general state. An echocardiography highlighted a left atrial mass on the interatrial septum, with a pedicular insertion. On the microscope, it consisted of a proliferation of stellate cells isolated or clustered in rudimentary vessels in a myxoid stroma presenting haemorrhage changes. These cells expressed CD34 and calretinine. Glandular elements without atypia were clustered within the myxomatous proliferation. They expressed cytokeratin (CK) 7. Surgical resection was macroscopically complete. In 2014, the boy had a sudden neurological deficit during a football match. An echocardiography revealed a recurrence at the same location. The lesion was excised and addressed in several fragments. Classical myxoma was associated with glands without atypia. This last component expressed CKAE1/AE3 and CK7. Ki67 index of proliferation was low. The surgical reintervention was macroscopically complete. The final diagnosis was glandular cardiac myxoma. A genetic survey was conducted, showing the presence of Carney complex. This is the first description in the litterature of a recurrent glandular cardiac myxoma occuring in a child.
authors.affiliation: Service d'anatomie et cytologie pathologique, groupement hospitalier Est, hospices civils de Lyon, 59, boulevard Pinel, 69677 Lyon, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Meurgey
authors.affiliation: Unité médico-chirurgicale des cardiopathies congénitales adultes et enfants, groupement hospitalier Est, hospices civils de Lyon, 69677 Lyon, France.
authors.forename: Roland
authors.initials: R
authors.lastname: Henaine
authors.affiliation: EA 4173, laboratoire cardiogénétique, groupement hospitalier Est, hospices civils de Lyon, université Lyon 1 et hôpital Nord Ouest, 69677 Lyon, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Bouvagnet
authors.affiliation: Service d'anatomie et cytologie pathologique, groupement hospitalier Est, hospices civils de Lyon, 59, boulevard Pinel, 69677 Lyon, France. Electronic address: lara.chalabreysse@chu-lyon.fr.
authors.forename: Lara
authors.initials: L
authors.lastname: Chalabreysse
mesh_terms: D002648:Child; D006325:Heart Atria / Q000473:pathology; D006338:Heart Neoplasms / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008297:Male; D009232:Myxoma / Q000175:diagnosis* / Q000628:therapy
keywords: Cardiac myxoma; Child; Composant glandulaire; Enfant; Glandular component; Immunohistochemistry; Immunohistochimie; Myxome cardiaque; Recurrent; Récidive