title: Thyroperoxidase antibodies and polycystic ovarian morphology.
abstract: OBJECTIVE
  To evaluate the association between polycystic ovarian morphology (PCOM) and thyroperoxidase antibody level.
  
  
  METHODS
  A cross-sectional study was undertaken of women aged 15-49years living in one of four provinces in Iran recruited between February 2009 and November 2010. Eligible women did not have hirsutism and were eumenorrheic. All participants underwent a comprehensive interview, clinical examination, blood sampling, and ultrasonographic assessment. The serum concentration of thyroperoxidase antibodies was compared between women with and without PCOM.
  
  
  RESULTS
  Among 491 participants, 74 (15.1%) had PCOM. In total, 11 (14.9%) women with PCOM and 61 (14.6%) women with normal morphology tested positive for thyroperoxidase antibodies. The serum concentration of thyroperoxidase antibodies was higher among women with PCOM (48.45±135.74IU/mL) than among those with normal ovarian morphology (37.99±96.49IU/mL), but the difference was not significant (P=0.42).
  
  
  CONCLUSIONS
  Thyroperoxidase antibody levels were higher in Iranian women with PCOM than in women with normal morphology, although the difference was not significant. Larger longitudinal studies are needed to investigate whether the treatment of thyroid disorders can prevent the development of PCOM.
authors.affiliation: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: ramezani@endocrine.ac.ir.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Ramezani Tehrani
authors.affiliation: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Bahri Khomami
authors.affiliation: Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Atieh
authors.initials: A
authors.lastname: Amouzegar
authors.affiliation: Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Azizi
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D015551:Autoimmunity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D007492:Iran; D016014:Linear Models; D008597:Menstrual Cycle / Q000097:blood; D006080:Ovarian Follicle / Q000000981:diagnostic imaging*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging*; D013961:Thyroid Gland / Q000503:physiopathology; D014463:Ultrasonography
chemical_list: D000974:Antibodies, Antinuclear; D007453:Iodide Peroxidase
keywords: Autoimmunity; Follicle number; Ovarian volume; Polycystic ovarian morphology; Thyroid; Thyroperoxidase antibodies