title: Retinas in a Dish Peek into Inherited Retinal Degeneration.
abstract: Human retinal degeneration can cause blindness, and the lack of relevant model systems has made identifying underlying mechanisms challenging. Parfitt et al. (2016) generate three-dimensional retinal tissue from patient-derived induced pluripotent stem cells to identify how CEP290 mutations cause retinal degeneration, and show an antisense approach can correct disease-associated phenotypes.
authors.affiliation: Center for Advanced Retinal and Ocular Therapeutics, F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
authors.forename: Thu T
authors.initials: TT
authors.lastname: Duong
authors.affiliation: Center for Advanced Retinal and Ocular Therapeutics, F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
authors.forename: Vidyullatha
authors.initials: V
authors.lastname: Vasireddy
authors.affiliation: Center for Advanced Retinal and Ocular Therapeutics, F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Mills
authors.affiliation: Center for Advanced Retinal and Ocular Therapeutics, F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: jebennet@mail.med.upenn.edu.
authors.forename: Jean
authors.initials: J
authors.lastname: Bennett
mesh_terms: D006801:Humans; D057026:Induced Pluripotent Stem Cells; D009154:Mutation; D012160:Retina; D012162:Retinal Degeneration / Q000235:genetics*