title: Acute inflammatory demyelinating polyradiculoneuropathy in a newborn infant.
abstract: BACKGROUND
  Acute inflammatory demyelinating polyneuropathy (AIDP), also known as Guillain-Barré syndrome, is an immune-mediated polyneuropathy usually triggered by infections or vaccinations. In childhood AIDP is commonly described after the first year of life. Here, we present a case of a newborn infant with AIDP manifestation directly after delivery.
  
  
  METHODS
  A newborn girl with a healthy mother, without known exposure to immunomodulating factors, was admitted to the neuropediatric department due to ascending hypotonia, weakness, pain and areflexia in the lower extremities. The clinical presentation, laboratory and neurophysiological studies supported the diagnosis of AIDP. The infant showed first signs of clinical improvement following administration of intravenous immunoglobulin and her recovery was complete at one year.
  
  
  CONCLUSIONS
  AIDP should be considered as a differential diagnosis in ascending hypotonia also in the neonatal period.
authors.affiliation: Neuropediatric Unit, Dept of Women's and Children's Health, Karolinska Institutet, Sweden. Electronic address: stavroula.anastasopoulou@karolinska.se.
authors.forename: Stavroula
authors.initials: S
authors.lastname: Anastasopoulou
authors.affiliation: Neuropediatric Unit, Dept of Women's and Children's Health, Karolinska Institutet, Sweden.
authors.forename: Marie
authors.initials: M
authors.lastname: Lindefeldt
authors.affiliation: Neonatal Unit, Dept of Women's and Children's Health, Karolinska Institutet, Sweden.
authors.forename: Marco
authors.initials: M
authors.lastname: Bartocci
authors.affiliation: Neuropediatric Unit, Dept of Women's and Children's Health, Karolinska Institutet, Sweden.
authors.forename: Ronny
authors.initials: R
authors.lastname: Wickström
mesh_terms: D005260:Female; D020275:Guillain-Barre Syndrome / Q000188:drug therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007231:Infant, Newborn
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: AIDP; Congenital; Guillain-Barré; Neonatal