title: The many faces of histone H3K79 methylation.
abstract: Dot1/DOT1L (disruptor of telomeric silencing-1) is an evolutionarily conserved histone methyltransferase that methylates lysine 79 located within the globular domain of histone H3. Dot1 was initially identified by a genetic screen as a disruptor of telomeric silencing in Saccharomyces cerevisiae; further, it is the only known non-SET domain containing histone methyltransferase. Methylation of H3K79 is involved in the regulation of telomeric silencing, cellular development, cell-cycle checkpoint, DNA repair, and regulation of transcription. hDot1L-mediated H3K79 methylation appears to have a crucial role in transformation as well as disease progression in leukemias involving several oncogenic fusion proteins. This review summarizes the multiple functions of Dot1/hDOT1L in a range of cellular processes.
authors.affiliation: Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar, Jammu, Kashmir 190006, India.
authors.forename: Zeenat
authors.initials: Z
authors.lastname: Farooq
authors.affiliation: Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar, Jammu, Kashmir 190006, India.
authors.forename: Shahid
authors.initials: S
authors.lastname: Banday
authors.affiliation: Department of Radiation Oncology, Houston Methodist Research Institute, Houston, TX 77030, USA.
authors.forename: Tej K
authors.initials: TK
authors.lastname: Pandita
authors.affiliation: Chromatin and Epigenetics Lab, Department of Biotechnology, University of Kashmir, Srinagar, Jammu, Kashmir 190006, India. Electronic address: altafbhat@uok.edu.in.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Altaf
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D002471:Cell Transformation, Neoplastic; D004260:DNA Repair; D004198:Disease Susceptibility; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D020868:Gene Silencing; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D016615:Telomere / Q000235:genetics / Q000378:metabolism
chemical_list: D006657:Histones
keywords: Chromatin; DNA repair; Histone methylation