title: The multiple functions of RNA helicases as drivers and regulators of gene expression.
abstract: RNA helicases comprise the largest family of enzymes involved in the metabolism of mRNAs, the processing and fate of which rely on their packaging into messenger ribonucleoprotein particles (mRNPs). In this Review, we describe how the capacity of some RNA helicases to either remodel or lock the composition of mRNP complexes underlies their pleiotropic functions at different steps of the gene expression process. We illustrate the roles of RNA helicases in coordinating gene expression steps and programmes, and propose that RNA helicases function as molecular drivers and guides of the progression of their mRNA substrates from one RNA-processing factory to another, to a productive mRNA pool that leads to protein synthesis or to unproductive mRNA pools that are stored or degraded.
authors.affiliation: Université de Lyon, École Normale Supérieure de Lyon, Université Claude Bernard, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 5239, Institut National de la Santé et de la Recherche Médicale (INSERM) U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d'Italie Site Jacques Monod, F-69007, Lyon, France.
authors.forename: Cyril F
authors.initials: CF
authors.lastname: Bourgeois
authors.affiliation: Université de Lyon, École Normale Supérieure de Lyon, Université Claude Bernard, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 5239, Institut National de la Santé et de la Recherche Médicale (INSERM) U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d'Italie Site Jacques Monod, F-69007, Lyon, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Mortreux
authors.affiliation: Université de Lyon, École Normale Supérieure de Lyon, Université Claude Bernard, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 5239, Institut National de la Santé et de la Recherche Médicale (INSERM) U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d'Italie Site Jacques Monod, F-69007, Lyon, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Auboeuf
mesh_terms: D000818:Animals; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D020365:RNA Helicases / Q000502:physiology*; D012326:RNA Splicing; D034443:RNA Transport; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D020365:RNA Helicases