title: Spatiotemporal Regulation of Hsp90-Ligand Complex Leads to Immune Activation.
abstract: Although heat shock proteins (HSPs) primarily play a pivotal role in the maintenance of cellular homeostasis while reducing extracellular as well as intracellular stresses, their role in immunologically relevant scenarios, including activation of innate immunity as danger signals, antitumor immunity, and autoimmune diseases, is now gaining much attention. The most prominent feature of HSPs is that they function both in their own and as an HSP-ligand complex. We here show as a unique feature of extracellular HSPs that they target chaperoned molecules into a particular endosomal compartment of dendritic cells, thereby inducing innate and adaptive immune responses via spatiotemporal regulation.
authors.affiliation: Department of Molecular Therapeutics, Center for Food and Medical Innovation, Institute for Innovation and Business Promotion, Hokkaido University , Sapporo , Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Tamura
authors.affiliation: Department of Molecular Therapeutics, Center for Food and Medical Innovation, Institute for Innovation and Business Promotion, Hokkaido University , Sapporo , Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yoneda
authors.affiliation: Department of Molecular Therapeutics, Center for Food and Medical Innovation, Institute for Innovation and Business Promotion, Hokkaido University , Sapporo , Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Takei
authors.affiliation: Department of Molecular Therapeutics, Center for Food and Medical Innovation, Institute for Innovation and Business Promotion, Hokkaido University , Sapporo , Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Sawada
keywords: autoimmune disease; cross-presentation; danger signal; dendritic cell; heat shock protein; toll-like receptor