title: From frames to OWL2: Converting the Foundational Model of Anatomy.
abstract: The Foundational Model of Anatomy (FMA) [Rosse C, Mejino JLV. A reference ontology for bioinformatics: the Foundational Model of Anatomy. J. Biomed. Inform. 2003;36:478-500] is an ontology that represents canonical anatomy at levels ranging from the entire body to biological macromolecules, and has rapidly become the primary reference ontology for human anatomy, and a template for model organisms. Prior to this work, the FMA was developed in a knowledge modeling language known as Protégé Frames. Frames is an intuitive representational language, but is no longer the industry standard. Recognizing the need for an official version of the FMA in the more modern semantic web language OWL2 (hereafter referred to as OWL), the objective of this work was to create a generalizable Frames-to-OWL conversion tool, to use the tool to convert the FMA to OWL, to "clean up" the converted FMA so that it classifies under an EL reasoner, and then to do all further development in OWL.
  
  
  
  The conversion tool is a Java application that uses the Protégé knowledge representation API for interacting with the initial Frames ontology, and uses the OWL-API for producing new statements (axioms, etc.) in OWL. The converter is relation centric. The conversion is configurable, on a property-by-property basis, via user-specifiable XML configuration files. The best conversion, for each property, was determined in conjunction with the FMA knowledge author. The convertor is potentially generalizable, which we partially demonstrate by using it to convert our Ontology of Craniofacial Development and Malformation as well as the FMA. Post-conversion cleanup involved using the Explain feature of Protégé to trace classification errors under the ELK reasoner in Protégé, fixing the errors, then re-running the reasoner.
  
  
  
  We are currently doing all our development in the converted and cleaned-up version of the FMA. The FMA (updated every 3 months) is available via our FMA web page http://si.washington.edu/projects/fma, which also provides access to mailing lists, an issue tracker, a SPARQL endpoint (updated every week), and an online browser. The converted OCDM is available at http://www.si.washington.edu/projects/ocdm. The conversion code is open source, and available at http://purl.org/sig/software/frames2owl. Prior to the post-conversion cleanup 73% of the more than 100,000 classes were unsatisfiable. After correction of six types of errors no classes remained unsatisfiable.
  
  
  
  Because our FMA conversion captures all or most of the information in the Frames version, is the only complete OWL version that classifies under an EL reasoner, and is maintained by the FMA authors themselves, we propose that this version should be the only official release version of the FMA in OWL, supplanting all other versions. Although several issues remain to be resolved post-conversion, release of a single, standardized version of the FMA in OWL will greatly facilitate its use in informatics research and in the development of a global knowledge base within the semantic web. Because of the fundamental nature of anatomy in both understanding and organizing biomedical information, and because of the importance of the FMA in particular in representing human anatomy, the FMA in OWL should greatly accelerate the development of an anatomically based structural information framework for organizing and linking a large amount of biomedical information.
authors.affiliation: Biological Structure, University of Washington Structural Informatics Group, 1959 NE Pacific Street, Box 357420, Seattle, Washington 98195, USA. Electronic address: det@uw.edu.
authors.forename: Landon T
authors.initials: LT
authors.lastname: Detwiler
authors.affiliation: Biological Structure, University of Washington Structural Informatics Group, 1959 NE Pacific Street, Box 357420, Seattle, Washington 98195, USA.
authors.forename: Jose L V
authors.initials: JLV
authors.lastname: Mejino
authors.affiliation: Biological Structure, University of Washington Structural Informatics Group, 1959 NE Pacific Street, Box 357420, Seattle, Washington 98195, USA; Computer Science and Engineering, University of Washington, Seattle, Washington 98195, USA; Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington 98195, USA.
authors.forename: James F
authors.initials: JF
authors.lastname: Brinkley
mesh_terms: D000715:Anatomy; D064229:Biological Ontologies; D019295:Computational Biology; D006801:Humans; D011381:Programming Languages; D000075403:Semantic Web
keywords: Foundational Model of Anatomy; Frames; OWL; Ontology; Ontology of Craniofacial Development and Malformation