title: Polyamine derivatives: a revival of an old neglected scaffold to fight resistant Gram-negative bacteria?
abstract: Emergence of multidrug-resistant pathogens was responsible for microbial infections and inefficacy of numerous antimicrobial therapies has induced a need for the research of new classes of antibiotics. In this review, we will focus our interest toward the biological properties of polyamino antimicrobial agents.
authors.affiliation: Centre de Recherche en Cancérologie de Marseille (CRCM), CNRS, UMR7258; Institut Paoli Calmettes.|Aix-Marseille Université, UM 105, Inserm, U1068, F-13009, Marseille, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Blanchet
authors.affiliation: UMR-MD1, Aix-Marseille Université, IRBA, TMCD2, 27 Bd Jean Moulin, 13385 Marseille, France.
authors.forename: Diane
authors.initials: D
authors.lastname: Borselli
authors.affiliation: Centre de Recherche en Cancérologie de Marseille (CRCM), CNRS, UMR7258; Institut Paoli Calmettes.|Aix-Marseille Université, UM 105, Inserm, U1068, F-13009, Marseille, France.
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Brunel
mesh_terms: D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011073:Polyamines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D011073:Polyamines
keywords: Gram-negative bacteria; antibiotic enhancers; antimicrobial agents; multidrug resistance; polyamines