title: [Spontaneous ovulation in in vitro fertilization-embryo transfer cycles using gonadotropin-releasing hormone antagonist: a large-sample retrospective study].
abstract: OBJECTIVE
  To investigate the premature spontaneous ovulation rates in in vitro fertilization-embryo transfer (IVF-ET) cycles using gonadotropin-releasing hormone antagonist (GnRH-ant) and gonadotropin-releasing hormone agonist (GnRH-a), as well as the risk factors for premature spontaneous ovulation.
  
  
  METHODS
  The rates of premature spontaneous ovulation in a total of 10 612 cycles using GnRH-ant or GnRH-a were compared. Matched case-controlled study and binary logistic regression model were conducted to analyze the risk factors for premature spontaneous ovulation.
  
  
  RESULTS
  The spontaneous ovulation rate in the whole for GnRH-a cycles was 0.15% (13/8 514), compared with a 1.62% (34/2 098) in GnRH-ant cycles (P<0.01). Further matched controlled study and regression analyze found out that higher basal FSH level was a predominant risk and prediction factor for spontaneous ovulation (OR=1.20, P=0.009).
  
  
  CONCLUSIONS
  In GnRH-ant cycles, spontaneous ovulation rate is about 10 times than which in GnRH-a cycles. Diminished ovarian function is a predominate risk factor for premature spontaneous ovulation.
authors.affiliation: Center of Reproductive Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: L
authors.initials: L
authors.lastname: Luo
authors.forename: M H
authors.initials: MH
authors.lastname: Chen
authors.forename: M X
authors.initials: MX
authors.lastname: Jia
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: C Q
authors.initials: CQ
authors.lastname: Zhou
mesh_terms: D016022:Case-Control Studies; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000378:metabolism; D006062:Gonadotropins / Q000037:antagonists & inhibitors*; D006727:Hormone Antagonists; D006801:Humans; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D006062:Gonadotropins; D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone