title: Correlation between the Modified Systemic Lupus Erythematosus Disease Activity Index 2000 and the European Consensus Lupus Activity Measurement in juvenile systemic lupus erythematosus.
abstract: Objective The objective of this study was to assess Modified Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and European Consensus Lupus Activity Measurement (ECLAM) disease activity correlation in addition to their respective correlation to Pediatric Systemic Lupus International Collaborative Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (Ped-SDI), in juvenile systemic lupus erythematosus (JSLE). Methods The activity indices were scored retrospectively and summarized by adjusted means during follow-up. The Ped-SDI was scored during the last visit for those with more than six months follow-up. Pearson correlation between the Modified SLEDAI-2K and ECLAM, as well as Spearman correlations between the Modified SLEDAI-2K, ECLAM, and Ped-SDI were calculated. The receiver operating characteristic (ROC) curve was calculated for both activity indices discriminating damage measured by Ped-SDI. Results Thirty-seven patients with mean age at diagnosis 11 ± 2.9 years and mean follow-up time 3.2 ± 2.4 years were studied. The Modified SLEDAI-2K and ECLAM adjusted means were highly correlated ( r = 0.78, p < 0.001). Similarly, Spearman correlation between the activity indices was also high ( rs> 0.7, p < 0.001), but Modified SLEDAI-2K and ECLAM correlation with Ped-SDI was only moderate. ROC analysis discriminant performance for both activity indices resulted in area under curve (AUC) of 0.74 and 0.73 for Modified SLEDAI-2K and ECLAM, respectively. Conclusion The high correlation found between the Modified SLEDAI-2K and ECLAM adjusted means indicated that both tools can be equally useful for longitudinal estimates of JSLE activity.
authors.affiliation: 1 Departamento de Pediatria, Faculdade de Medicina de Botucatu, UNESP-Universidade Estadual Paulista, São Paulo, Brazil.
authors.forename: J O
authors.initials: JO
authors.lastname: Sato
authors.affiliation: 2 Departamento de Bioestatística, Instituto de Biociências, Campus de Botucatu, UNESP-Universidade Estadual Paulista, São Paulo, Brazil.
authors.forename: J E
authors.initials: JE
authors.lastname: Corrente
authors.affiliation: 1 Departamento de Pediatria, Faculdade de Medicina de Botucatu, UNESP-Universidade Estadual Paulista, São Paulo, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Saad-Magalhães
mesh_terms: D000293:Adolescent; D002648:Child; D006801:Humans; D003299:Cooperative Behavior; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000453:epidemiology; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D003245:Consensus Statements as Topic
keywords: Activity; ECLAM; Modified SLEDAI-2K; childhood-onset systemic lupus erythematosus; damage; juvenile systemic lupus erythematosus