title: QuantiFERON-TB Gold Assay on Plasma for Confirmation of Presumed Tuberculosis-Related Uveitis.
abstract: The QuantiFERON-TB Gold assay was used to measure interferon gamma levels in plasma from 4 patients with presumed tuberculosis-related uveitis before, during, and after antitubercular therapy. After treatment, all patients showed clinical improvement. The concentrations showed a reversion to an absence of interferon gamma in one case, decreased in two cases, and remained stable in one case. These results suggest that the QuantiFERON assay may be useful for tuberculosis-related uveitis diagnosis and follow-up.
authors.affiliation: Department of Biomedical Sciences, Section of Experimental and Clinical Microbiology, University of Sassari, Sassari, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Zanetti
authors.affiliation: Department of Biomedical Sciences, Section of Experimental and Clinical Microbiology, University of Sassari, Sassari, Italy ale.b76@email.it.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bua
authors.affiliation: Department of Biomedical Sciences, Section of Experimental and Clinical Microbiology, University of Sassari, Sassari, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Molicotti
authors.affiliation: Department of Surgical, Microsurgical, and Medical Sciences, Ophthalmology Unit, University of Sassari, Sassari, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Maiore
authors.affiliation: Department of Surgical, Microsurgical, and Medical Sciences, Ophthalmology Unit, University of Sassari, Sassari, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pinna
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage; D003955:Diagnostic Tests, Routine / Q000379:methods*; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D059425:Interferon-gamma Release Tests / Q000379:methods*; D008297:Male; D010949:Plasma / Q000737:chemistry*; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy; D014605:Uveitis / Q000209:etiology*
chemical_list: D000995:Antitubercular Agents; D007371:Interferon-gamma