title: Relevance of Endoplasmic Reticulum Stress Cell Signaling in Liver Cold Ischemia Reperfusion Injury.
abstract: The endoplasmic reticulum (ER) is involved in calcium homeostasis, protein folding and lipid biosynthesis. Perturbations in its normal functions lead to a condition called endoplasmic reticulum stress (ERS). This can be triggered by many physiopathological conditions such as alcoholic steatohepatitis, insulin resistance or ischemia-reperfusion injury. The cell reacts to ERS by initiating a defensive process known as the unfolded protein response (UPR), which comprises cellular mechanisms for adaptation and the safeguarding of cell survival or, in cases of excessively severe stress, for the initiation of the cell death program. Recent experimental data suggest the involvement of ERS in ischemia/reperfusion injury (IRI) of the liver graft, which has been considered as one of major problems influencing outcome after liver transplantation. The purpose of this review is to summarize updated data on the molecular mechanisms of ERS/UPR and the consequences of this pathology, focusing specifically on solid organ preservation and liver transplantation models. We will also discuss the potential role of ERS, beyond the simple adaptive response and the regulation of cell death, in the modification of cell functional properties and phenotypic changes.
authors.affiliation: Experimental Pathology Department, Instituto de Investigaciones Biomédicas de Barcelona, Spanish Research Council (IIBB-CSIC), Rosselló 161, 08036-Barcelona, Catalonia, Spain. efpbam@iibb.csic.es.
authors.forename: Emma
authors.initials: E
authors.lastname: Folch-Puy
authors.affiliation: Experimental Pathology Department, Instituto de Investigaciones Biomédicas de Barcelona, Spanish Research Council (IIBB-CSIC), Rosselló 161, 08036-Barcelona, Catalonia, Spain. arnau.panisello@iibb.csic.es.
authors.forename: Arnau
authors.initials: A
authors.lastname: Panisello
authors.affiliation: Department of Medicine, LaBioMed at Harbor UCLA Medical Center, Torrance, 90502 CA, USA. joliva@labiomed.org.
authors.forename: Joan
authors.initials: J
authors.lastname: Oliva
authors.affiliation: Centre Hépatobiliaire, AP-HP Hôpital Paul Brousse, Inserm U935, Université Paris-Sud, Villejuif, 75008 Paris, France. alexandregl.lopez@gmail.com.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Lopez
authors.affiliation: Centre Hépatobiliaire, AP-HP Hôpital Paul Brousse, Inserm U935, Université Paris-Sud, Villejuif, 75008 Paris, France. ccastrob@gmail.com.
authors.forename: Carlos
authors.initials: C
authors.lastname: Castro Benítez
authors.affiliation: Centre Hépatobiliaire, AP-HP Hôpital Paul Brousse, Inserm U935, Université Paris-Sud, Villejuif, 75008 Paris, France. rene.adam@pbr.aphp.fr.
authors.forename: René
authors.initials: R
authors.lastname: Adam
authors.affiliation: Experimental Pathology Department, Instituto de Investigaciones Biomédicas de Barcelona, Spanish Research Council (IIBB-CSIC), Rosselló 161, 08036-Barcelona, Catalonia, Spain. joan.rosello@iibb.csic.es.
authors.forename: Joan
authors.initials: J
authors.lastname: Roselló-Catafau
mesh_terms: D000818:Animals; D017209:Apoptosis; D059865:Endoplasmic Reticulum Stress; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D016031:Liver Transplantation; D009926:Organ Preservation; D015427:Reperfusion Injury / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D056811:Unfolded Protein Response
keywords: Institut Georges Lopez-1 (IGL-1) solution; University Wisconsin (UW) solution; endoplasmic reticulum stress; liver ischemia reperfusion injury; orthotopic liver transplantation; unfolded protein response