title: Prophylactic Gynecologic Specimens from Hereditary Cancer Carriers.
abstract: Hereditary breast ovarian cancer and Lynch/hereditary nonpolyposis colorectal cancer syndrome account for most hereditary gynecologic cancers. In the absence of effective cancer screening and other preventative strategies, risk-reducing surgery in women who are known to be at genetic risk of BRCA-associated or of Lynch syndrome carcinomas is effective in significantly decreasing the lifetime risk of developing malignancy. Reflex genomic testing of high-grade ovarian cancers and reflex immunohistochemistry in endometrial cancers will lead to greater recognition of germline-associated cancers. Approaches to processing surgical specimens, the recognition and classification of cancer precursor lesions, and differentiation from their mimics are discussed.
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Pathology, University Health Network, Toronto, Ontario, Canada. Electronic address: Patricia.shaw@uhn.ca.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Shaw
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Pathology, University Health Network, Toronto, Ontario, Canada.
authors.forename: Blaise A
authors.initials: BA
authors.lastname: Clarke
mesh_terms: D024682:BRCA2 Protein / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D005260:Female; D020022:Genetic Predisposition to Disease; D061325:Hereditary Breast and Ovarian Cancer Syndrome / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D007044:Hysterectomy; D055847:Lynch Syndrome II / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D010052:Ovariectomy; D011230:Precancerous Conditions / Q000175:diagnosis / Q000601:surgery; D058994:Salpingectomy / Q000379:methods; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
chemical_list: D024682:BRCA2 Protein; C551750:BRCA2 protein, human; C111164:BRAP protein, human; D044767:Ubiquitin-Protein Ligases
keywords: BRCA; Endometrial cancer; Hereditary cancer; Lynch syndrome; Ovarian cancer; Prophylactic surgery; Risk-reducing salpingectomy; Salpingo-oophorectomy