title: Risk Stratification and Prognosis in Sepsis: What Have We Learned from Microarrays?
abstract: Sepsis mortality rates have decreased in recent years but remain unacceptably high. Risk stratification and prognostication is of particular importance because high-risk patients may benefit from earlier clinical interventions, whereas low-risk patients may benefit from not undergoing unnecessary procedures. Prognostication is currently done mostly via clinical criteria and blood lactate levels. This article summarizes the literature on the complexity of changes at the molecular level for the casual reader.
authors.affiliation: Department of Surgery, Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Sweeney
authors.affiliation: Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati Children's Research Foundation, 3333 Burnet Avenue, MLC2005, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: hector.wong@cchmc.org.
authors.forename: Hector R
authors.initials: HR
authors.lastname: Wong
mesh_terms: D015415:Biomarkers / Q000097:blood*; D006801:Humans; D011379:Prognosis; D012306:Risk; D018805:Sepsis / Q000235:genetics*; D046888:Tissue Array Analysis / Q000379:methods*
chemical_list: D015415:Biomarkers
keywords: Biomarker; Gene expression; Microarray; Prognostics; Sepsis