title: Synergistic Effects of Gold Nanocages in Hyperthermia and Radiotherapy Treatment.
abstract: Gold nanocages (GNCs) are a promising material that not only converts near infrared (NIR) light to heat for the ablation of tumors but also acts as a radiosensitizer. The combination of hyperthermia and radiotherapy has a synergistic effect that can lead to significant tumor cell necrosis. In the current study, we synthesized GNCs that offered the combined effects of hyperthermia and radiotherapy. This combination strategy resulted in increased tumor cell apoptosis and significant tumor tissue necrosis. We propose that GNCs can be used for clinical treatment and to potentially overcome resistance to radiotherapy by clearly increasing the antitumor effect.
authors.affiliation: Department of Radiology, Qilu Hospital, Shandong University, Jinan, 250012, People's Republic of China.
authors.forename: Ai-Wei
authors.initials: AW
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Department of Chemistry, Shandong University, Jinan, People's Republic of China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Guo
authors.affiliation: Department of Radiology, Qilu Hospital, Shandong University, Jinan, 250012, People's Republic of China.
authors.forename: Ya-Fei
authors.initials: YF
authors.lastname: Qi
authors.affiliation: Department of Radiotherapy, Qilu Hospital, Shandong University, Jinan, People's Republic of China.
authors.forename: Jian-Zhen
authors.initials: JZ
authors.lastname: Wang
authors.affiliation: Department of Radiology, Qilu Hospital, Shandong University, Jinan, 250012, People's Republic of China. xiangxingma2006@163.com.
authors.forename: Xiang-Xing
authors.initials: XX
authors.lastname: Ma
authors.affiliation: Department of Radiology, Qilu Hospital, Shandong University, Jinan, 250012, People's Republic of China. ydx0330@sina.com.
authors.forename: De-Xin
authors.initials: DX
authors.lastname: Yu
keywords: Breast cancer; Gold nanocages (GNCs); Hyperthermia; Radiosensitivity; Targeted cancer therapy