title: miRNA expression and function in thyroid carcinomas: a comparative and critical analysis and a model for other cancers.
abstract: As in many cancer types, miRNA expression profiles and functions have become an important field of research on non-medullary thyroid carcinomas, the most common endocrine cancers. This could lead to the establishment of new diagnostic tests and new cancer therapies. However, different studies showed important variations in their research strategies and results. In addition, the action of miRNAs is poorly considered as a whole because of the use of underlying dogmatic truncated concepts. These lead to discrepancies and limits rarely considered. Recently, this field has been enlarged by new miRNA functional and expression studies. Moreover, studies using next generation sequencing give a new view of general miRNA differential expression profiles of papillary thyroid carcinoma. We analyzed in detail this literature from both physiological and differential expression points of view. Based on explicit examples, we reviewed the progresses but also the discrepancies and limits trying to provide a critical approach of where this literature may lead. We also provide recommendations for future studies. The conclusions of this systematic analysis could be extended to other cancer types.
authors.affiliation: Institute of Interdisciplinary Research (IRIBHM), University of Brussels, Brussels, Belgium.
authors.forename: Manuel
authors.initials: M
authors.lastname: Saiselet
authors.affiliation: Institute of Interdisciplinary Research (IRIBHM), University of Brussels, Brussels, Belgium.
authors.forename: Jaime M
authors.initials: JM
authors.lastname: Pita
authors.affiliation: Institute of Interdisciplinary Research (IRIBHM), University of Brussels, Brussels, Belgium.
authors.forename: Alice
authors.initials: A
authors.lastname: Augenlicht
authors.affiliation: Institute of Interdisciplinary Research (IRIBHM), University of Brussels, Brussels, Belgium.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Dom
authors.affiliation: Institute of Interdisciplinary Research (IRIBHM), University of Brussels, Brussels, Belgium.
authors.forename: Maxime
authors.initials: M
authors.lastname: Tarabichi
authors.affiliation: Institute of Interdisciplinary Research (IRIBHM), University of Brussels, Brussels, Belgium.
authors.forename: Danai
authors.initials: D
authors.lastname: Fimereli
authors.affiliation: Institute of Interdisciplinary Research (IRIBHM), University of Brussels, Brussels, Belgium.
authors.forename: Jacques E
authors.initials: JE
authors.lastname: Dumont
authors.affiliation: Institute of Interdisciplinary Research (IRIBHM), University of Brussels, Brussels, Belgium.
authors.forename: Vincent
authors.initials: V
authors.lastname: Detours
authors.affiliation: Institute of Interdisciplinary Research (IRIBHM), University of Brussels, Brussels, Belgium.|WELBIO, School of Medicine, University of Brussels, Brussels, Belgium.
authors.forename: Carine
authors.initials: C
authors.lastname: Maenhaut
mesh_terms: D020869:Gene Expression Profiling; D006801:Humans; D035683:MicroRNAs / Q000032:analysis* / Q000096:biosynthesis; D013964:Thyroid Neoplasms / Q000235:genetics*; D059467:Transcriptome
chemical_list: D035683:MicroRNAs
keywords: cancer; expression profile; function; miRNA; thyroid