title: Association of type 2 diabetes susceptibility loci with peripheral nerve function in a Chinese population with diabetes.
abstract: OBJECTIVE
  Previous studies have suggested a possible relationship between type 2 diabetes mellitus susceptibility loci and diabetic complications. The present study aimed to investigate the associations between type 2 diabetes mellitus loci with peripheral nerve function in a Chinese population with type 2 diabetes mellitus.
  
  
  METHODS
  A total of 1,900 type 2 diabetes mellitus patients were recruited in the study. We selected ten single nucleotide polymorphisms (SNPs) from ten type 2 diabetes mellitus susceptibility genes previously confirmed in Chinese patients. Genotyping was carried out by using a MassARRAY Compact Analyzer. Peripheral nerve function was evaluated by nerve conduction studies in all participants. The composite Z-scores for nerve conduction parameters including conduction velocity (CV), amplitude and latency were calculated, respectively.
  
  
  RESULTS
  Rs5219 of KCNJ11 (E23K, G→A) was identified to be associated with all the parameters obtained from nerve conduction studies (Z-score of CV: β = 0.113, P = 0.01; Z-score of amplitude: β = 0.133, P = 0.01; Z-score of latency: β = -0.116, P = 0.01) after adjustment for covariates including age, duration and glycated hemoglobin. Specifically, each copy of the A allele was related to better outcomes. CDKAL1 rs7756992 and TCF7L2 rs7903146 correlated with the composite Z-score of amplitude (P = 0.028 and P = 0.016, respectively), but not CV (P = 0.393 and P = 0.281, respectively) or latency (P = 0.286 and P = 0.273, respectively). There were no significant associations between the other seven SNPs and peripheral nerve function.
  
  
  CONCLUSIONS
  Rs5219 at KCNJ11 (E23K) was associated with peripheral nerve function in a Chinese population with type 2 diabetes mellitus, suggesting shared genetic factors for type 2 diabetes mellitus and diabetic polyneuropathy in this population.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Hu
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.
authors.forename: Congrong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.|Shanghai Diabetes Institute, Shanghai, China.|Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.|Shanghai Clinical Center for Diabetes, Shanghai, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000368:Aged; D044466:Asian People / Q000208:ethnology; D002681:China / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics*; D003929:Diabetic Neuropathies / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide
keywords: Diabetic neuropathy; Genetics; Nerve conduction study