title: Dynamic enhancement patterns of intrahepatic cholangiocarcinoma in cirrhosis on contrast-enhanced computed tomography: risk of misdiagnosis as hepatocellular carcinoma.
abstract: This study aimed to assess the features of intrahepatic cholangiocarcinoma (ICC) at computerized tomography (CT) and verify the risk of misdiagnosis of ICC as hepatocellular carcinoma (HCC) in cirrhosis. CT appearances of 98 histologically confirmed ICC nodules from 84 cirrhotic patients were retrospectively reviewed, taking into consideration the pattern and dynamic contrast uptake during the arterial, portal venous and delayed phases. During the arterial phase, 53 nodules (54.1%) showed peripheral rim-like enhancement, 35 (35.7%) hyperenhancement, 9 (9.2%) hypoenhancement and 1 (1.0%) isoenhancement. The ICC nodules showed heterogeneous dynamic contrast patterns, being progressive enhancement in 35 nodules (35.7%), stable enhancement in 28 nodules (28.6%), wash-in and wash-out pattern in 15 nodules (15.3%) and all other enhancement patterns in 20 nodules (20.4%). There were no significant differences in the dynamic vascular patterns of ICC according to nodule size (p > 0.05). ICC in cirrhosis has varied enhancement patterns at contrast-enhanced multiphase multidetector CT. Though the majority of ICC did not display typical radiological hallmarks of HCC, if dynamic CT scan was used as the sole modality for the non-invasive diagnosis of nodules in cirrhosis, the risk of misdiagnosis of ICC for HCC is not negligible.
authors.affiliation: Dept. Hepato-biliary-Pancreatic Surgery, Southwest Hospital Affiliated to Third Military Medical University, P. R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: Dept. Radiology, Southwest Hospital Affiliated to Third Military Medical University, P. R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Cai
authors.affiliation: Dept. Hepato-biliary-Pancreatic Surgery, Southwest Hospital Affiliated to Third Military Medical University, P. R. China.
authors.forename: Kuan-Sheng
authors.initials: KS
authors.lastname: Ma
authors.affiliation: Dept. Radiology, Southwest Hospital Affiliated to Third Military Medical University, P. R. China.
authors.forename: Shi-Yi
authors.initials: SY
authors.lastname: Ding
authors.affiliation: Dept. Pathology, Southwest Hospital Affiliated to Third Military Medical University, P. R. China.
authors.forename: De-Yu
authors.initials: DY
authors.lastname: Guo
authors.affiliation: Dept. Pathology, Southwest Hospital Affiliated to Third Military Medical University, P. R. China.
authors.forename: Xiao-Chu
authors.initials: XC
authors.lastname: Yan
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives; D008103:Liver Cirrhosis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D012189:Retrospective Studies; D016037:Single-Blind Method; D012907:Smoking; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D003287:Contrast Media; D007472:Iohexol; C038192:iopromide