title: Comparison of Asymmetric Dimethylarginine Levels Between Stages Three, Four, and Five Non-dialysis of Chronic Kidney Disease.
abstract: OBJECTIVE
  to determine the differences of ADMA level between stages 3, 4, and 5 non-dialysis of chronic kidney disease (CKD) patients at Outpatient Nephrology Clinic, Dr. Soetomo Hospital.
  
  
  METHODS
  a cross-sectional study was conducted on stage 3, 4, and 5 non-dialysis CKD patients at Outpatient Nephrology Clinic, Dr. Soetomo Hospital, Surabaya from January to February 2015. Stages of CKD were determined based on GFR estimation according to 4-variable MDRD formula. Statistical analysis of differences in the levels of ADMA in three subject groups use one-way ANOVA test.
  
  
  RESULTS
  seventy-five patients were included in the study. Each group consisted of 25 patients stage 3, 4, and, 5 non-dialysis patients. Mean age of stage 3, stage 4, and stage 5 non-dialysis CKD patients were respectively 57.12 years, 54.80 years and 53.68 years. The mean levels of ADMA in stage 3, stage 4, and 5 were 0.62 (0.11) IU/mL, 0.72 (0.16) IU/mL, and 0.73 (0.18) IU/mL respectively. Analysis of the differences between the groups showed significant differences in ADMA levels (p=0.04), with the highest difference between stage 3 and stage 5.
  
  
  CONCLUSIONS
  comparison of ADMA levels showed significant differences between CKD stages and the level tends to be higher along with increase severity of CKD stages.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.
authors.forename: Tri P
authors.initials: TP
authors.lastname: Asmarawati
authors.lastname: Widodo
authors.forename: M
authors.initials: M
authors.lastname: Thaha
authors.lastname: Aditiawardana
authors.forename: Nunuk
authors.initials: N
authors.lastname: Mardiana
authors.forename: Ardityo R
authors.initials: AR
authors.lastname: Ardhany
authors.forename: Artaria
authors.initials: A
authors.lastname: Tjempakasari
authors.forename: Djoko
authors.initials: D
authors.lastname: Santoso
authors.lastname: Pranawa
authors.forename: Chandra
authors.initials: C
authors.lastname: Irwanadi
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000175:diagnosis
chemical_list: C018524:N,N-dimethylarginine; D001120:Arginine