title: Molecular characterization of the first G24P[14] rotavirus strain detected in humans.
abstract: Here we report the genome of a novel rotavirus A (RVA) strain detected in a stool sample collected during routine surveillance by the Centers for Disease Control and Prevention's New Vaccine Surveillance Network. The strain, RVA/human-wt/USA/2012741499/2012/G24P[14], has a genomic constellation of G24-P[14]-I2-R2-C2-M2-A3-N2-T9-E2-H3. The VP2, VP3, VP7 and NSP3 genes cluster phylogenetically with bovine strains. The other genes occupy mixed clades containing animal and human strains. Strain RVA/human-wt/USA/2012741499/2012/G24P[14] most likely is the product of interspecies transmission and reassortment events. This is the second report of the G24 genotype and the first report of the G24P[14] genotype combination in humans.
authors.affiliation: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: mrw0@cdc.gov.
authors.forename: M Leanne
authors.initials: ML
authors.lastname: Ward
authors.affiliation: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: hsr7@cdc.gov.
authors.forename: Slavica
authors.initials: S
authors.lastname: Mijatovic-Rustempasic
authors.affiliation: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: sunando@gmail.com.
authors.forename: Sunando
authors.initials: S
authors.lastname: Roy
authors.affiliation: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: Torekunchala@gmail.com.
authors.forename: Kunchala
authors.initials: K
authors.lastname: Rungsrisuriyachai
authors.affiliation: Texas Children's Hospital, Houston, TX, USA; Baylor College of Medicine, Houston, TX, USA. Electronic address: jaboom@texaschildrens.org.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Boom
authors.affiliation: Texas Children's Hospital, Houston, TX, USA. Electronic address: lcsahni@texaschildrens.org.
authors.forename: Leila C
authors.initials: LC
authors.lastname: Sahni
authors.affiliation: Texas Children's Hospital, Houston, TX, USA; Baylor College of Medicine, Houston, TX, USA. Electronic address: cbaker@bcm.edu.
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Baker
authors.affiliation: Texas Children's Hospital, Houston, TX, USA; Baylor College of Medicine, Houston, TX, USA. Electronic address: mrench@bcm.edu.
authors.forename: Marcia A
authors.initials: MA
authors.lastname: Rench
authors.affiliation: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: ezq1@cdc.gov.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Wikswo
authors.affiliation: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: dvp6@cdc.gov.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Payne
authors.affiliation: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: uap2@cdc.gov.
authors.forename: Umesh D
authors.initials: UD
authors.lastname: Parashar
authors.affiliation: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: mkb6@cdc.gov.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Bowen
mesh_terms: D000818:Animals; D002417:Cattle; D002675:Child, Preschool; D016679:Genome, Viral; D005838:Genotype; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008297:Male; D010802:Phylogeny; D016865:Reassortant Viruses / Q000145:classification / Q000235:genetics*; D012401:Rotavirus / Q000145:classification / Q000235:genetics*; D012400:Rotavirus Infections / Q000821:virology; D013781:Texas; D017361:Viral Nonstructural Proteins / Q000235:genetics*
chemical_list: D017361:Viral Nonstructural Proteins
keywords: Bovine; G24P[14]; Reassortment; Rotavirus