title: The Mechanisms and Pharmacological Strategy for Treatment of ER Stress-induced Metabolic Syndrome.
abstract: Obesity is one of the major risk factors of metabolic syndrome, such as hypertension, hyperlipidemia, and diabetes. Leptin exerts an anti-obesity effect through the Ob-Rb leptin receptor, which is mainly expressed on hypothalamic neuronal cells. Recent evidence indicated that one of the mechanisms of obesity may be the development of leptin resistance. In the present review, we discuss the mechanisms of leptin resistance in obesity, focusing on endoplasmic reticulum (ER) stress. We previously found that flurbiprofen is a candidate drug for attenuating ER stress and the subsequent development of leptin resistance. We will discuss a possible pharmacological strategy for treating obesity by ameliorating ER stress.
authors.affiliation: Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University.
authors.forename: Toru
authors.initials: T
authors.lastname: Hosoi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Ozawa
mesh_terms: D055808:Drug Discovery; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects / Q000502:physiology*; D005480:Flurbiprofen / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D020738:Leptin / Q000378:metabolism / Q000502:physiology; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000209:etiology*; D009765:Obesity / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D054411:Receptors, Leptin / Q000378:metabolism / Q000502:physiology; D012307:Risk Factors
chemical_list: D020738:Leptin; D054411:Receptors, Leptin; D005480:Flurbiprofen