title: Serum Salusin-β Levels Are Correlated with Slow Coronary Flow.
abstract: BACKGROUND
  Slow coronary flow (SCF) is a special coronary microvascular disorder associated with recurrent chest pain. The pathogenesis of SCF remain unclear.
  
  
  OBJECTIVE
  We sought to assess whether serum salusin-β levels are correlated with SCF.
  
  
  METHODS
  We enrolled 76 patients with angiographically confirmed SCF and 108 age- and gender-matched controls. We measured serum salusin-β levels by enzyme-linked immunosorbent assay and coronary flow rate was assessed using thrombolysis in myocardial infarction frame count (TFC).
  
  
  RESULTS
  Serum salusin-β levels were elevated in SCF patients compared with controls (4.33 [range 3.52-5.87] nmol/L vs. 3.76 [range 2.98-4.67] nmol/L). Multivariate logistic regression analysis revealed that salusin-β in serum was the independent predictor of SCF (odds ratio = 1.814). Serum salusin-β levels were independently correlated with mean-TFC (r = 0.355, p = 0.002).
  
  
  CONCLUSIONS
  Serum salusin-β levels were independently associated with SCF. Therefore, our findings implicate a potential role of salusin-β in the pathophysiology of SCF and provide insights on both risk stratification and modification in this patient population.
authors.affiliation: 1 Department of Cardiology, Shandong Jiaotong Hospital , Jinan, China .
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: 2 Department of Cardiology, People's Hospital of Linzi District , Zibo, China .
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Dong
authors.affiliation: 3 Department of Clinical Microbiology, People's Hospital of Linzi District , Zibo, China .
authors.forename: Hong-Yun
authors.initials: HY
authors.lastname: Cao
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D054318:No-Reflow Phenomenon / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins; C478739:TOR2A protein, human