title: Selection and Application of Aptamers and Intramers.
abstract: Aptamers are auspicious nucleic acid ligands for targeting different molecules, such as small molecules, peptides, proteins, or even whole living cells. They are short single-stranded DNA or RNA oligonucleotides, which can fold into complex three-dimensional structures and bind selectively their targets. Using the combinatorial chemistry process SELEX (Systematic Evolution of Ligands by EXponential Enrichment), target specific aptamers can be selected. These aptamers have a variety of application possibilities and can be used as sensors, diagnostic, imaging or therapeutic agents, and in the field of regenerative medicine for tissue engineering.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University Hospital Tuebingen, Calwerstr. 7/1, 72076, Tuebingen, Germany. meltem.avci-adali@klinikum.uni-tuebingen.de.|RiNA GmbH, Berlin, Germany. meltem.avci-adali@klinikum.uni-tuebingen.de.
authors.forename: Meltem
authors.initials: M
authors.lastname: Avci-Adali
mesh_terms: D000818:Animals; D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000627:therapeutic use*; D015195:Drug Design; D018390:Gene Targeting; D006801:Humans; D011506:Proteins / Q000037:antagonists & inhibitors*; D052156:SELEX Aptamer Technique / Q000379:methods
chemical_list: D052157:Aptamers, Nucleotide; D011506:Proteins
keywords: Aptamers; Intramers; SELEX; Spiegelmers; Targeting