title: Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake.
abstract: Plasma strawberry anthocyanins were characterized in overweight (BMI: 26 ± 2 kg/m(2)) adults (n = 14) on the basis of meal timing. At each visit, subjects ingested three study drinks: two control and one strawberry drink. A strawberry drink was given at either 2 h before the breakfast meal (BM), with the meal (WM), or 2 h after the meal (AM), and control drinks were given at the alternative time points. Plasma anthocyanins and their metabolic conjugates were assessed hourly for 10 h using a triple-quadrupole liquid chromatography mass spectrometer. Maximum concentrations (Cmax), area under the curve (AUC), and bioavailability of pelargonidin-based anthocyanins determined from the main conjugated metabolite (pelargonidin glucuronide) were greater when a strawberry drink was consumed 2 h before the meal (BM) compared to consumption WM or AM (p < 0.05). Our results indicate that the timing of strawberry consumption relative to a meal impacts anthocyanin pharmacokinetic variables.
authors.affiliation: Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology , Bedford Park, Illinois 60501, United States.
authors.forename: Amandeep K
authors.initials: AK
authors.lastname: Sandhu
authors.affiliation: Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology , Bedford Park, Illinois 60501, United States.
authors.forename: Yancui
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology , Bedford Park, Illinois 60501, United States.
authors.forename: Di
authors.initials: D
authors.lastname: Xiao
authors.affiliation: Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology , Bedford Park, Illinois 60501, United States.
authors.forename: Eunyoung
authors.initials: E
authors.lastname: Park
authors.affiliation: Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology , Bedford Park, Illinois 60501, United States.
authors.forename: Indika
authors.initials: I
authors.lastname: Edirisinghe
authors.affiliation: Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology , Bedford Park, Illinois 60501, United States.|Department of Nutrition, University of California , Davis, California 95616, United States.
authors.forename: Britt
authors.initials: B
authors.lastname: Burton-Freeman
mesh_terms: D000328:Adult; D000872:Anthocyanins / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D005260:Female; D031985:Fragaria / Q000737:chemistry / Q000378:metabolism*; D005638:Fruit / Q000737:chemistry / Q000378:metabolism; D000067030:Fruit and Vegetable Juices / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000872:Anthocyanins
keywords: HPLC; anthocyanins; bioavailability; glucuronide; strawberries