title: Placental growth factor (PlGF) and sFlt-1 during pregnancy: physiology, assay and interest in preeclampsia.
abstract: The placental growth factor (PlGF) and its soluble receptor (sFlt-1) are circulating angiogenic factors. During pregnancy these factors are released by the placenta into the maternal circulation. Preeclampsia affects 2-7% of pregnant women according to their risk factors and is characterized by high blood pressure and the onset of de novo proteinuria in the second half of pregnancy. Alterations of the sFlt-1/PlGF ratio in preeclampsia correlate with the diagnosis and adverse outcomes, particularly when the disease presents prematurely (<34 weeks). These factors can be assayed in maternal blood and measuring the sFlt-1/PlGF ratio is now available. We propose in this work to update the knowledge of these two molecules, describe their roles and evolution during normal pregnancy and preeclampsia, and finally to focus on the available assays.
authors.affiliation: Inserm UMR-S 1139, Physiopathologie et pharmacotoxicologie placentaire humaine, Paris, France, Département de gynécologie obstétrique I, Maternité Port-Royal, Centre hospitalier universitaire Cochin-Broca-Hôtel-Dieu, Groupe Hospitalier Universitaire Ouest, AP-HP, Paris, France, Fondation Premup, Paris, France, DHU Risques et grossesse, Paris, France, PRES Sorbonne Paris-Cité, Université Paris-Descartes, Paris, France.
authors.forename: Édouard
authors.initials: É
authors.lastname: Lecarpentier
authors.affiliation: Inserm UMR-S 1139, Physiopathologie et pharmacotoxicologie placentaire humaine, Paris, France, Département de gynécologie obstétrique, CHI Créteil, CRC CHI Créteil, Université Paris Est Créteil, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Vieillefosse
authors.affiliation: Inserm UMR-S 1139, Physiopathologie et pharmacotoxicologie placentaire humaine, Paris, France, Fondation Premup, Paris, France, Département de gynécologie obstétrique, CHI Créteil, CRC CHI Créteil, Université Paris Est Créteil, France.
authors.forename: Bassam
authors.initials: B
authors.lastname: Haddad
authors.affiliation: Inserm UMR-S 1139, Physiopathologie et pharmacotoxicologie placentaire humaine, Paris, France, Fondation Premup, Paris, France, DHU Risques et grossesse, Paris, France, PRES Sorbonne Paris-Cité, Université Paris-Descartes, Paris, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Fournier
authors.affiliation: Laboratoire d'hormonologie, Centre hospitalier universitaire Cochin Broca-Hôtel-Dieu, Groupe hospitalier universitaire Ouest, AP-HP, Paris, France.
authors.forename: Marie-Clémence
authors.initials: MC
authors.lastname: Leguy
authors.affiliation: Inserm UMR-S 1139, Physiopathologie et pharmacotoxicologie placentaire humaine, Paris, France, Fondation Premup, Paris, France, DHU Risques et grossesse, Paris, France, PRES Sorbonne Paris-Cité, Université Paris-Descartes, Paris, France, Laboratoire d'hormonologie, Centre hospitalier universitaire Cochin Broca-Hôtel-Dieu, Groupe hospitalier universitaire Ouest, AP-HP, Paris, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Guibourdenche
authors.affiliation: Inserm UMR-S 1139, Physiopathologie et pharmacotoxicologie placentaire humaine, Paris, France, Département de gynécologie obstétrique I, Maternité Port-Royal, Centre hospitalier universitaire Cochin-Broca-Hôtel-Dieu, Groupe Hospitalier Universitaire Ouest, AP-HP, Paris, France, Fondation Premup, Paris, France, DHU Risques et grossesse, Paris, France, PRES Sorbonne Paris-Cité, Université Paris-Descartes, Paris, France.
authors.forename: Vassilis
authors.initials: V
authors.lastname: Tsatsaris
mesh_terms: D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D000072483:Placenta Growth Factor / Q000097:blood / Q000502:physiology*; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011247:Pregnancy / Q000097:blood; D011263:Pregnancy Trimester, Third / Q000097:blood; D011296:Prenatal Diagnosis / Q000379:methods; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood / Q000502:physiology*
chemical_list: D015415:Biomarkers; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1
keywords: angiogenic factors; placenta; placental growth factor; prééclampsia; sFlt-1