title: Treatment of Intrabony Defects by DFDBA Alone or in Combination with PRP: A Split-Mouth Randomized Clinical and Three-Dimensional Radiographic Trial.
abstract: OBJECTIVE
  The efficacy of adding platelet-rich plasma (PRP) to demineralized freeze-dried bone allograft (DFDBA) in order to improve the clinical and radiographic results obtained in treatment of deep periodontal intrabony defects has yet to be fully elucidated.
  
  
  METHODS
  This double blind, split-mouth randomized controlled clinical trial was conducted on 12 patients with two comparable bilateral intrabony defects. Each pair of defects was randomly treated with DFDBA+PRP (test) or DFDBA alone (control). Clinical attachment level (CAL), intrabony defect depth (IDD), distance from the stent to the alveolar crest and pocket depth (PD) as well as radiographic parameters including the radiographic defect depth, width and angulation were measured at baseline and six months post-operatively. The paired t-test was used to compare the pre and post-treatment values and the unpaired t-test compared the test and control groups.
  
  
  RESULTS
  The mean reductions in PD and CAL were 4.5 ±1.3 mm and 3.6±1.6 mm in sites treated with DFDBA+ PRP, respectively (P<0.01); these reductions were 4.1±1.4 mm and 3.5±1.3 mm, respectively in DFDBA group (P<0.01). Radiographic evaluation revealed 2.5±1.1 mm reduction in the radiographic defect depth in the test and 2.1±1.2 mm in the control sites. The defect angulation increased at both sites. Statistically, there were no significant differences between the two treatment modalities (P<0.01).
  
  
  CONCLUSIONS
  This study showed that both treatments resulted in significant PD reduction, CAL gain and IDD reduction. Also, PRP failed to enhance the results obtained by DFDBA.
authors.affiliation: Associate Professor, Department of Periodontics, Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Hengameh
authors.initials: H
authors.lastname: Khosropanah
authors.affiliation: Professor, Department of Radiology, Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Shoaleh
authors.initials: S
authors.lastname: Shahidi
authors.affiliation: Postgraduate Student, Department of Periodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Amar
authors.initials: A
authors.lastname: Basri
authors.affiliation: Postgraduate Student, Department of Periodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Maral
authors.initials: M
authors.lastname: Houshyar
keywords: Allografts; Cell- and Tissue-Based Therapy; Cone-Beam Computed Tomography; Platelet-Rich Plasma