title: Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking.
abstract: To evaluate exposure to tobacco, marijuana, and indoor heating/cooking sources in relation to antimüllerian hormone (AMH) levels.
  
  
  
  Cross-sectional analysis in a sample of premenopausal women (n = 913) enrolled in the Sister Study cohort (n = 50,884).
  
  
  
  Not applicable.
  
  
  
  Women, ages 35-54 years at time of enrollment, with an archived serum sample and at least one intact ovary and classified as premenopausal.
  
  
  
  Not applicable.
  
  
  
  Serum AMH (ng/mL) levels ascertained by ultrasensitive ELISA assay.
  
  
  
  Lower AMH levels were associated with sources of indoor heating, including burning wood (-36.0%; 95% confidence interval [CI], -55.7%, -7.8%) or artificial fire logs (-45.8%; 95% CI, -67.2%, -10.4%) at least 10 times/year in a residential indoor stove/fireplace. Lower AMH levels were also observed in women who were current smokers of ≥20 cigarettes/day relative to nonsmokers (-56.2%; 95% CI, -80.3%, -2.8%) and in women with 10+ years of adult environmental tobacco smoke (ETS) exposure (-31.3%; 95% CI, -51.3%, -3.1%), but no associations were observed for marijuana use.
  
  
  
  We confirmed previously reported findings of lower AMH levels in current heavy smokers and also found associations for long-term ETS exposure and indoor burning of wood or artificial fire logs. These findings suggest that combustion by-products from common exposures can have toxic effects on the human ovary.
authors.affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. Electronic address: alexandra.white@nih.gov.
authors.forename: Alexandra J
authors.initials: AJ
authors.lastname: White
authors.affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
authors.forename: Dale P
authors.initials: DP
authors.lastname: Sandler
authors.affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; Social and Scientific Systems, Inc., Durham, North Carolina.
authors.forename: Aimee A
authors.initials: AA
authors.lastname: D'Aloisio
authors.affiliation: Department of Obstetrics and Gynecology and Department of Preventative Medicine, University of Southern California Keck School of Medicine, Los Angeles, California.
authors.forename: Frank
authors.initials: F
authors.lastname: Stanczyk
authors.affiliation: Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health at Houston, San Antonio Regional Campus, San Antonio, Texas; Southwest Center for Occupational and Environmental Health, University of Texas School of Public Health at Houston, Houston, Texas.
authors.forename: Kristina W
authors.initials: KW
authors.lastname: Whitworth
authors.affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
authors.forename: Donna D
authors.initials: DD
authors.lastname: Baird
authors.affiliation: Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina.
authors.forename: Hazel B
authors.initials: HB
authors.lastname: Nichols
mesh_terms: D000328:Adult; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003296:Cooking; D003430:Cross-Sectional Studies; D005260:Female; D006361:Heating / Q000009:adverse effects*; D006798:Housing; D006801:Humans; D002189:Marijuana Abuse / Q000097:blood / Q000150:complications*; D008385:Marijuana Smoking / Q000009:adverse effects* / Q000097:blood; D008875:Middle Aged; D011647:Puerto Rico; D018570:Risk Assessment; D012307:Risk Factors; D035781:Siblings; D012907:Smoking / Q000009:adverse effects* / Q000097:blood; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D014481:United States; D016387:Women's Health
chemical_list: D015415:Biomarkers; D014028:Tobacco Smoke Pollution; D054304:Anti-Mullerian Hormone
keywords: Anti-Müllerian Hormone; Tobacco; breast cancer; environmental tobacco smoke; indoor air pollution