title: The prognostic value of exercise-induced ventricular arrhythmias in patients with and without coronary artery disease: A meta-analysis.
abstract: BACKGROUND
  Significance of exercise-induced ventricular arrhythmias (EIVAs) is controversial. This meta-analysis aimed to determine the prognostic value of EIVAs in patients with and without coronary artery disease (CAD).
  
  
  METHODS
  Relevant studies were searched on Pubmed though December, 2015. Pooled odds ratio (OR) of endpoints (all-cause death, cardiac death or cardiac events) for all included studies was calculated at first to explore the significance of EVIAs in unselected population. Then, sensitivity analysis based on CAD status of population was performed to determine ORs of endpoints in CAD population, non-CAD population and mixed population, respectively.
  
  
  RESULTS
  A total of 14 studies examining 23,002 patients were included, with 5 studies involved CAD population, 4 involved non-CAD population, and 5 involved mixed population (%CAD ranged from 51.2% to 76.8%). EIVAs in unselected population were associated with a pooled OR of 1.626 (95%CI 1.334 to 1.983, p<0.001) of endpoints when compared with those without EIVAs. Sensitivity analysis further indicated that pooled ORs of endpoints were 1.395 (95%CI 1.061 to 1.833, p=0.017) in CAD population, 1.933 (95%CI 1.567 to 2.384, p<0.001) in non-CAD population, and 1.402 (95%CI 1.198 to 1.640, p<0.001) in mixed population. Heterogeneous among studies was identified. Meta-regression analysis found that study quality, mean follow-up period, percentage of lost, percentage of diabetes were associated with ORs of endpoints.
  
  
  CONCLUSIONS
  EIVAs were associated with increased risk of worse outcomes, no matter the patients had CAD or not. However, more studies are required to confirm this finding due to the variation of current evidences.
authors.affiliation: Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Long
authors.initials: L
authors.lastname: Peng
authors.affiliation: Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Suhua
authors.initials: S
authors.lastname: Li
authors.affiliation: Advanced medical center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Xixiang
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Yanting
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Yunyue
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Ruimin
authors.initials: R
authors.lastname: Dong
authors.affiliation: Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Zhenda
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Xujing
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China. Electronic address: zhujieming2011@126.com.
authors.forename: Jieming
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China. Electronic address: medicine2lsh@163.com.
authors.forename: Jinlai
authors.initials: J
authors.lastname: Liu
mesh_terms: D000328:Adult; D003324:Coronary Artery Disease / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014693:Ventricular Fibrillation / Q000209:etiology*; D000070857:Walk Test / Q000009:adverse effects*
keywords: Arrhythmia; Coronary artery disease; Exercise testing; Mortality; Prognosis