title: Association between serum uric acid, urinary albumin excretion, and glycated hemoglobin in Type 2 diabetic patient.
abstract: BACKGROUND
  Diabetes mellitus (DM) is a chronic disease characterized by insulin deficiency or peripheral resistance resulting in hyperglycemia. Poor glycemic control leads to diabetic complications. Hyperuricemia has been reported with increased risk of renal insufficiency. The aim of this study was to evaluate the relationship between serum uric acid concentration, degree of urinary albumin excretion (UAE) and glycated hemoglobin (HbA1c) in Type 2 DM (T2DM) patients.
  
  
  METHODS
  Serum uric acid concentrations, urine microalbumin, and HbA1c were measured in fifty T2DM patients. We then evaluated relationship between uric acid concentrations, degree of UAE and glycemic control as well as other confounding variables.
  
  
  RESULTS
  Serum uric acid concentration correlated positively with UAE (r = 0.323, P < 0.05), age (r = 0.337, P < 0.05), age at onset (r = 0.341, P < 0.05), and duration of DM (r = 0.312, P < 0.05). Multiple regression analysis demonstrated that serum uric acid concentration (β = 0.293, P < 0.0001), duration of DM (β = 0.261, P < 0.0001), HbA1c (β = 0.173, P < 0.005), and systolic blood pressure (β = 0.268, P < 0.005) were independent determinants of UAE.
  
  
  CONCLUSIONS
  Serum uric acid concentration is associated with microalbuminuria and HbA1c in T2DM patients.
authors.affiliation: Department of Biochemistry, Universal College of Medical Sciences, Bhairawaha, Nepal.
authors.forename: Sunita
authors.initials: S
authors.lastname: Neupane
authors.affiliation: Department of Biochemistry, Universal College of Medical Sciences, Bhairawaha, Nepal.
authors.forename: Raju Kumar
authors.initials: RK
authors.lastname: Dubey
authors.affiliation: Department of Biochemistry, Universal College of Medical Sciences, Bhairawaha, Nepal.
authors.forename: Narayan
authors.initials: N
authors.lastname: Gautam
authors.affiliation: Department of Internal Medicine, Universal College of Medical Sciences, Bhairawaha, Nepal.
authors.forename: Krishna Kumar
authors.initials: KK
authors.lastname: Agrawal
authors.affiliation: Department of Biochemistry, Universal College of Medical Sciences, Bhairawaha, Nepal.
authors.forename: Archana
authors.initials: A
authors.lastname: Jayan
authors.affiliation: Department of Biochemistry, Universal College of Medical Sciences, Bhairawaha, Nepal.
authors.forename: Sujata
authors.initials: S
authors.lastname: Shrestha
authors.affiliation: Department of Biochemistry, Universal College of Medical Sciences, Bhairawaha, Nepal.
authors.forename: Amit Chandra
authors.initials: AC
authors.lastname: Jha
keywords: Glycated hemoglobin; Type 2 diabetes mellitus; microalbumin; uric acid