title: Preventive effect of dexketoprofen on postoperative pain.
abstract: OBJECTIVE
  Preventive analgesia has been defined as reduction in noxious stimuli during preoperative, intraoperative, and postoperative periods. The aim of the present study was to prevent central sensitization by administering ketamine infusion throughout the surgical procedure. In addition, possible preventive effects of dexketoprofen when administered before and after incision were evaluated.
  
  
  METHODS
  Fifty patients were included. Group I was administered 50 mg intravenous dexketoprofen prior to surgical incision, and Group II received the same amount 10 minutes after the incision had been made. Following induction of general anesthesia, all patients received a bolus of 0.50 mg/kg ketamine in 0.07 mg/kg/h intravenous infusion.
  
  
  RESULTS
  When postoperative visual analog scale values were compared, values for Group I after 1 and 4 hours were significantly lower than those of Group II. In addition, morphine consumption at 4, 8, 12, and 24 hours was significantly lower in Group I.
  
  
  CONCLUSIONS
  Combined with the prevention of central sensitization with ketamine, administration of dexketoprofen prior to incision led to a lower rate of morphine consumption and more effective analgesia than post-incision administration.
authors.affiliation: Department of Anesthesiology and Reanimation, Hacettepe Faculty of Medicine, Ankara, Turkey.
authors.forename: İsmail Kerem
authors.initials: İK
authors.lastname: Gelir
authors.affiliation: Department of Anesthesiology and Reanimation, Osmangazi University Faculty of Medicine, Eskişehir, Turkey.
authors.forename: Sacit
authors.initials: S
authors.lastname: Güleç
authors.affiliation: Department of Anesthesiology and Reanimation, Osmangazi University Faculty of Medicine, Eskişehir, Turkey. drdcetinkaya@mynet.com.
authors.forename: Dilek
authors.initials: D
authors.lastname: Ceyhan
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007430:Intraoperative Care; D007660:Ketoprofen / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D011300:Preoperative Care; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen