title: Brain structure, executive function and appetitive traits in adolescent obesity.
abstract: Children with obesity show differences in brain structure, executive function and appetitive traits when compared with lean peers. Little is known on the relationship between brain structure and these traits.
  
  
  
  To investigate the relationship between differences in brain structure and executive function and appetitive traits, in obese and lean adolescents.
  
  
  
  MRI was used to measure cortical thickness and subcortical volumes. Executive function was measured by a Stop Signal-and a Choice Delay Task. Appetitive traits were measured using the Child Eating Behaviour Questionnaire.
  
  
  
  Adolescents with obesity had greater volumes of the pallidum; 1.78 mL (SE 0.03, p=0.014), when compared with controls; 1.65 mL (SE 0.02). In the group with obesity, greater pallidum volume was positively associated with the ability to delay reward in the Choice Delay Task (p=0.012).
  
  
  
  The association between pallidum volumes and Choice Delay Task in obese adolescents supports the hypothesis that the pallidum plays an important role in executive dysfunction in obese children.
authors.affiliation: Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: C J
authors.initials: CJ
authors.lastname: de Groot
authors.affiliation: Sophia Children's Hospital, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: E L T
authors.initials: ELT
authors.lastname: van den Akker
authors.affiliation: Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.|Sophia Children's Hospital, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: E H H M
authors.initials: EHHM
authors.lastname: Rings
authors.affiliation: Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: H A
authors.initials: HA
authors.lastname: Delemarre-van de Waal
authors.affiliation: Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: van der Grond
mesh_terms: D000293:Adolescent; D001921:Brain / Q000503:physiopathology*; D002648:Child; D002652:Child Behavior; D056344:Executive Function; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D063766:Pediatric Obesity / Q000503:physiopathology*; D011795:Surveys and Questionnaires
keywords: Adolescent obesity; amygdala; appetitive traits; executive function