title: Pseudomonas aeruginosa: targeting cell-wall metabolism for new antibacterial discovery and development.
abstract: Pseudomonas aeruginosa is a leading cause of hospital-acquired infections and is resistant to most antibiotics. With therapeutic options against P. aeruginosa dwindling, and the lack of new antibiotics in advanced developmental stages, strategies for preserving the effectiveness of current antibiotics are urgently required. β-Lactam antibiotics are important agents for treating P. aeruginosa infections, thus, adjuvants that potentiate the activity of these compounds are desirable for extending their lifespan while new antibiotics - or antibiotic classes - are discovered and developed. In this review, we discuss recent research that has identified exploitable targets of cell-wall metabolism for the design and development of compounds that hinder resistance and potentiate the activity of antipseudomonal β-lactams.
authors.affiliation: Department of Biochemistry & Biomedical Sciences & the Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Ryan P
authors.initials: RP
authors.lastname: Lamers
authors.affiliation: Department of Biochemistry & Biomedical Sciences & the Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Lori L
authors.initials: LL
authors.lastname: Burrows
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002473:Cell Wall / Q000187:drug effects* / Q000378:metabolism*; D055808:Drug Discovery; D008826:Microbial Sensitivity Tests; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents
keywords: AmpC β-lactamase; antibiotic adjuvant; biofilm; cell-wall metabolism; combination therapy; opportunistic pathogen; β-lactam antibiotics