title: [The association of the DRD3 gene with Parkinson's disease].
abstract: OBJECTIVE
  To investigate the association between dopamine receptor DRD3 gene tag single nucleotide polymorphisms (SNPs) and the risk of Parkinson's disease (PD).
  
  
  METHODS
  One hundred and forty-three patients with PD and 96 healthy individuals from the Russian population were examined. Ten tag SNPs (rs963468, rs2134655, rs9817063, rs324035, rs11721264, rs1800828, rs3773678, rs167770, rs167771, rs7633291) within DRD3 have been genotyped.
  
  
  CONCLUSIONS
  Associations between 4 polymorphisms (rs11721264, rs3773678, rs167771, rs324035) and PD have been found. Our study confirms the involvement of polymorphic features of dopamine receptors genes in the pathophysiology in PD.
authors.affiliation: Mental Health Research Institute, Tomsk, Russia; National Research Tomsk Polytechnic University,Tomsk, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Ivanova
authors.affiliation: Siberian State Medical Iniversity, Tomsk, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Alifirova
authors.affiliation: Siberian State Medical Iniversity, Tomsk, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Zhukova
authors.affiliation: Mental Health Research Institute, Tomsk, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Boiko
authors.affiliation: Mental Health Research Institute, Tomsk, Russia; National Research Tomsk Polytechnic University,Tomsk, Russia.
authors.forename: O Yu
authors.initials: OY
authors.lastname: Fedorenko
authors.affiliation: Siberian State Medical Iniversity, Tomsk, Russia.
authors.forename: N G
authors.initials: NG
authors.lastname: Zhukova
authors.affiliation: Mental Health Research Institute, Tomsk, Russia; Siberian State Medical Iniversity, Tomsk, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Bokhan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D050637:Receptors, Dopamine D3 / Q000235:genetics*; D012426:Russia
chemical_list: C493593:DRD3 protein, human; D050637:Receptors, Dopamine D3