title: Bioinformatics evaluation of the possibility of heat shock proteins as autoantigens in multiple sclerosis based on molecular mimicry hypothesis.
abstract: Molecular mimicry is the explanatory link between the heat shock proteins (HSPs) of infectious agents and triggering multiple sclerosis. Considering that there are many similarities between self- and bacterial-HSPs, the goal was to investigate a panel of 60- and 70kDa HSPs from a variety of bacteria in order to predict the role of each microorganism in triggering or progression of the disease under the molecular mimicry hypothesis. By clarifying the peptides meeting criteria for cross-reactivity and elucidating the role of each microorganism in MS pathogenesis, it would be easier to suggest more effective treatment and preventive strategies for this disease.
authors.affiliation: Department of Pharmaceutical Biotechnology and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Safa
authors.initials: S
authors.lastname: Ansari Qeshmi
authors.affiliation: Department of Pharmaceutical Biotechnology and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Faculty of Pahrmacy and Pharmaceutical Sciences, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Dabbagh
authors.affiliation: Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Afshin
authors.initials: A
authors.lastname: Borhani Haghighi
authors.affiliation: Department of Pharmaceutical Biotechnology and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: ghasemiy@sums.ac.ir.
authors.forename: Younes
authors.initials: Y
authors.lastname: Ghasemi
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology / Q000378:metabolism; D019295:Computational Biology; D003429:Cross Reactions; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D016056:Immunodominant Epitopes; D018716:Molecular Mimicry; D008970:Molecular Weight; D009103:Multiple Sclerosis / Q000276:immunology* / Q000378:metabolism*; D020539:Sequence Analysis, Protein
chemical_list: D001324:Autoantigens; D001426:Bacterial Proteins; D006360:Heat-Shock Proteins; D016056:Immunodominant Epitopes
keywords: Autoimmunity; Heat shock proteins (HSPs); Immunoinformatics; Molecular mimicry; Multiple Sclerosis (MS)