title: Can synaptophysin be used as a marker of breast cancer diagnosed by core-needle biopsy in epithelial proliferative diseases of the breast?
abstract: The differential diagnosis of epithelial proliferative disease using core needle biopsy (CNB) is problematic because it is difficult to differentiate between intraductal papilloma, ductal hyperplasia, ductal carcinoma in situ, and invasive ductal carcinoma. Many studies have reported that breast cancer lesions are positive for neuroendocrine (NE) markers, whereas only a small number of studies have reported immunopositivity for NE markers in normal mammary tissues or benign lesions. We asked whether NE factors could be used as markers of breast cancer. We determined the immunopositivity rate of synaptophysin, an NE marker, in 204 lesions excised from the breast using CNB in patients who visited a university-affiliated comprehensive medical facility and examined whether synaptophysin is a marker of breast cancer. The specimens were classified as synaptophysin-negative cases (56 benign, 99 malignant); equivocal cases (<1 %: 2 benign, 15 malignant); and synaptophysin-positive cases (1 benign, 31 malignant). The sensitivity, specificity, positive predictive value, and negative predictive value for malignancy of the lesions classified as synaptophysin positive were 23.3 %, 98.2 %, 96.9 %, and 36.1 %, respectively. The respective values for lesions classified as equivocal were 11.6 %, 96.6 %, 88.2 %, and 36.1 %. Synaptophysin may provide a marker of breast cancer diagnosed by CNB.
authors.affiliation: Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Maeda
authors.affiliation: Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Tajima
authors.affiliation: Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ariizumi
authors.affiliation: Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Masatomo
authors.initials: M
authors.lastname: Doi
authors.affiliation: Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Endo
authors.affiliation: Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Saeko
authors.initials: S
authors.lastname: Naruki
authors.affiliation: Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hoshikawa
authors.affiliation: Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Koizumi
authors.affiliation: Department of Radiology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Kanemaki
authors.affiliation: Unit of Medical Statistics, Faculty of Medical Education and Culture, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Ueno
authors.affiliation: Department of Breast and Endocrine Surgery, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tsugawa
authors.affiliation: Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Takagi
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism* / Q000592:standards; D062005:Biopsy, Large-Core Needle; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D015203:Reproducibility of Results; D016708:Synaptophysin / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D016708:Synaptophysin
keywords: breast; core needle biopsy; neuroendocrine cell hyperplasia; sensitivity; synaptophysin