title: IL-10 gene polymorphism is associated with preschool atopy and early-life recurrent wheezing after bronchiolitis in infancy.
abstract: Variations in the genes that regulate innate immunity responses may be associated with susceptibility to asthma or atopy after early-life bronchiolitis. The aim of this study was to evaluate the association between four different polymorphisms of the IL-10 gene at rs1800871, rs1800872, rs1800890, and rs1800896, either alone or in combination, and post-bronchiolitis asthma or allergies at 5-7 years of age.
  
  
  
  Data on single nucleotide polymorphisms (SNP) of IL-10 rs1800896 (-1082G/A), rs1800871 (-819C/T), rs1800872 (-592C/A), and IL-10 rs1800890 (-3575T/A) were available for 135 children. Polymorphisms and their associations with asthma and allergies were studied in 135 preschool-aged children who had been hospitalized for bronchiolitis at age 0-6 months. Their parents were interviewed to record the children's history with asthma and allergies from infancy to the present.
  
  
  
  At 6.4 years (mean), asthma was present in 17 children (12.6%), while recurrent wheezing during the first 7 years of life was present in 39 (28.9%) children. Fifty-three (39.3%) study participants had current atopy (atopic eczema or allergic rhinitis). Eight (72%) of 11 children with the IL-10 rs1800896, IL-10 rs1800871, and IL-10 rs1800872 combination AA + CT + CA had current atopy (P = 0.02 vs. 38% in other genotype combinations). Twenty-three (56%) children with the IL-10 rs1800871C/T or IL-10 rs1800872C/A genotype had present atopy versus 34 (38%) with other IL-10 genotypes (P = 0.03). Between 2 years and 3 years of age, 27% of ATA haplotype carriers had asthma versus 13.7% of other haplotype carriers (P = 0.02).
  
  
  
  IL-10 polymorphisms at rs1800871, rs1800872, rs1800890, and rs1800896 seem to be associated with elevated allergies and/or recurrent wheezing risk in later childhood, after early-life bronchiolitis. Pediatr Pulmonol. 2017;52:14-20. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
authors.forename: Matti
authors.initials: M
authors.lastname: Korppi
authors.affiliation: Department of Pediatrics, Seinäjoki Central Hospital, Seinäjoki, Finland.
authors.forename: Kirsi
authors.initials: K
authors.lastname: Nuolivirta
authors.affiliation: Tampere University Hospital, Tampere, Finland.
authors.forename: Eero
authors.initials: E
authors.lastname: Lauhkonen
authors.affiliation: Department of Pediatrics, Seinäjoki Central Hospital, Seinäjoki, Finland.
authors.forename: Annukka
authors.initials: A
authors.lastname: Holster
authors.affiliation: Department of Medical Microbiology and Immunology, Turku University, Turku, Finland.
authors.forename: Johanna
authors.initials: J
authors.lastname: Teräsjärvi
authors.affiliation: Department of Medical Microbiology and Immunology, Turku University, Turku, Finland.
authors.forename: Juho
authors.initials: J
authors.lastname: Vuononvirta
authors.affiliation: Tampere University Hospital, Tampere, Finland.
authors.forename: Merja
authors.initials: M
authors.lastname: Helminen
authors.affiliation: Department of Medical Microbiology and Immunology, Turku University, Turku, Finland.|Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Turku, Finland.
authors.forename: Qiushui
authors.initials: Q
authors.lastname: He
authors.affiliation: Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
authors.forename: Petri
authors.initials: P
authors.lastname: Koponen
mesh_terms: D001249:Asthma / Q000150:complications / Q000235:genetics*; D001988:Bronchiolitis / Q000150:complications / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000150:complications / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012135:Respiratory Sounds; D065631:Rhinitis, Allergic / Q000150:complications / Q000235:genetics*
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: RSV; asthma; atopic dermatitis; atopy; bronchiolitis; genes; interleukin-10; polymorphism; recurrent wheezing