title: Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumors.
abstract: Lymphatic dissemination is one of the most important pathways for metastasis in many solid tumors, including head and neck carcinomas. The lymphatic growth of cancer has been used as a significant independent adverse prognostic factor and provides information about tumor progression. Salivary gland tumors present different prognoses and have the ability to develop metastases; however, this information regarding the lymphatic spread is scarce. This paper quantifies the lymphatic microvessel density (LMD) in benign and malignant salivary gland tumors and analyzes the relationship between LMD and tumor expression of vascular endothelial growth factors C (VEGF-C) and the proliferative index. The results show that there is no correlation between LMD, VEGF-C and the proliferative index in the majority of salivary gland tumors analyzed, apart from polymorphous low-grade carcinoma which exhibits statistical correlation between LMD and the proliferative index (p < 0.05). This correlation probably does not indicate a poor prognosis for this PLGA, since this is a low metastasizing carcinoma of the salivary glands. Different from other solid tumors, such as breast or prostatic carcinomas, there is no correlation between VEGF-C and LMD in salivary gland tumors, and so these traits are not able to estimate the metastatic risk or the prognosis of these tumors.
authors.affiliation: Department of Bioscience and Oral Diagnosis, Dental School-Institute of Science and Technology (ICT), Univ. Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, 12245-000, Brazil. gimenesgimenes@hotmail.com.
authors.forename: Márcia Gimenes
authors.initials: MG
authors.lastname: Americo
authors.affiliation: Department of Bioscience and Oral Diagnosis, Dental School-Institute of Science and Technology (ICT), Univ. Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, 12245-000, Brazil.
authors.forename: Yonara Maria Freire Soares
authors.initials: YM
authors.lastname: Marques
authors.affiliation: Department of Bioscience and Oral Diagnosis, Dental School-Institute of Science and Technology (ICT), Univ. Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, 12245-000, Brazil.
authors.forename: Milagros Del Valle
authors.initials: MD
authors.lastname: El Abras Ankha
authors.affiliation: Department of Bioscience and Oral Diagnosis, Dental School-Institute of Science and Technology (ICT), Univ. Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, 12245-000, Brazil.
authors.forename: Renata Falchete
authors.initials: RF
authors.lastname: do Prado
authors.affiliation: Department of Bioscience and Oral Diagnosis, Dental School-Institute of Science and Technology (ICT), Univ. Estadual Paulista (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, São Paulo, 12245-000, Brazil.
authors.forename: Yasmin Rodarte
authors.initials: YR
authors.lastname: Carvalho
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D049109:Cell Proliferation; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D042601:Lymphatic Vessels / Q000098:blood supply* / Q000473:pathology*; D055806:Microvessels / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000098:blood supply* / Q000473:pathology*; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism*
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D042582:Vascular Endothelial Growth Factor C; C500987:monoclonal antibody D2-40
keywords: Lymphatic microvessel density; Prognoses; Proliferative index; Salivary gland tumors; VEGF-C