title: Anti-Inflammatory Effects and Prediction of Blood Pressure Response by Baseline Inflammatory State in Catheter-Based Renal Denervation.
abstract: This retrospective analysis aimed to examine off-target effects on inflammatory and renal function parameters in n=78 subsequent patients treated with renal denervation (RDN) for resistant hypertension. Ambulatory and office blood pressure (ABP/OBP), serum creatinine, glomerular filtration rate (GFR), cystatin C, C-reactive protein (CRP), interleukin-6 (IL-6), and white blood cell count (WBC) were assessed before, 6 and 12 months after RDN. ABP was significantly reduced by -8.2/-3.8 mm Hg (P=.002/.021) at 1 year after RDN, while an initial OBP reduction was not sustained during follow-up. IL-6 levels significantly decreased by -0.5 pg/mL (P=.042) and by -1.7 pg/mL (P<.001) at 6 and 12 months, baseline IL-6 levels possibly predicting ABP response to RDN (r=-0.295; P=.020). Concurrently, leukocyte count was reduced by -0.5 × 103/μL (P=.017) and -0.8 × 103/μL (P<.001), respectively. Serum creatinine and GFR remained unchanged, but we observed a significant increase in cystatin C by 0.04 mg/L (P=.026) and 0.14 mg/L (P<.001) at 6 and 12 months after the intervention.
authors.affiliation: Clinic of Internal Medicine 1, Kepler University Clinic, Linz, Austria. david.lang@akh.linz.at.
authors.forename: David
authors.identifier: 0000-0002-3098-1554
authors.initials: D
authors.lastname: Lang
authors.affiliation: Clinic of Internal Medicine 1, Kepler University Clinic, Linz, Austria.
authors.forename: Alexander
authors.initials: A
authors.lastname: Nahler
authors.affiliation: Clinic of Internal Medicine 1, Kepler University Clinic, Linz, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lambert
authors.affiliation: Clinic of Internal Medicine 1, Kepler University Clinic, Linz, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Grund
authors.affiliation: Clinic of Internal Medicine 1, Kepler University Clinic, Linz, Austria.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kammler
authors.affiliation: Clinic of Internal Medicine 1, Kepler University Clinic, Linz, Austria.
authors.forename: Jörg
authors.initials: J
authors.lastname: Kellermair
authors.affiliation: Clinic of Internal Medicine 1, Kepler University Clinic, Linz, Austria.
authors.forename: Hermann
authors.initials: H
authors.lastname: Blessberger
authors.affiliation: Clinic of Internal Medicine 1, Kepler University Clinic, Linz, Austria.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kypta
authors.affiliation: Clinic of Internal Medicine 1, Kepler University Clinic, Linz, Austria.
authors.forename: Clemens
authors.initials: C
authors.lastname: Steinwender
authors.affiliation: Clinic of Internal Medicine 1, Kepler University Clinic, Linz, Austria.|Department of Internal Medicine 1, St. Josef Hospital, Braunau, Austria.
authors.forename: Johann
authors.initials: J
authors.lastname: Auer
mesh_terms: D000368:Aged; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002097:C-Reactive Protein / Q000378:metabolism; D055316:Cystatin C / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000276:immunology / Q000601:surgery*; D015850:Interleukin-6 / Q000097:blood; D007668:Kidney / Q000276:immunology / Q000294:innervation / Q000503:physiopathology* / Q000601:surgery*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013562:Sympathectomy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D055316:Cystatin C; C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein