title: Estrogen-mediated dental tissue regeneration.
abstract: As the key regulator of hard tissue metabolism in both men and women, estrogen regulates the processes necessary for cell growth, proliferation, and differentiation through estrogen receptor (ER). Estrogen deficiency usually causes systemic osteoporosis not only in long bones but also in jaw bones, and exogenous estrogen can enhance the osteogenic potential of mesenchymal stem cells. Dental mesenchymal stem cells (DMSCs) represent a group of stem cells isolated from different parts of the tooth, including dental pulps, apical papillae and periodontal ligaments. A number of studies have proved that estrogen plays an important role in the proliferation, differentiation and tissue regeneration of human DMSCs. Thus, this review will focus on the effects of estrogen on proliferation, apoptosis, and differentiation of dental stem cells, discuss evidence from studies in rodents that estrogen plays an important role in dental morphogenesis as well as periodontal remodeling, and suggest directions for future studies in estrogen-related tooth regeneration.
authors.affiliation: Key Laboratory of Oral Diseases of Jiangsu Province and Stomatological School of Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Yadie
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Key Laboratory of Oral Diseases of Jiangsu Province and Stomatological School of Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Jin
authors.affiliation: Key Laboratory of Oral Diseases of Jiangsu Province and Stomatological School of Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Lei
authors.affiliation: Key Laboratory of Oral Diseases of Jiangsu Province and Stomatological School of Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Yujin
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Key Laboratory of Oral Diseases of Jiangsu Province and Stomatological School of Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Yanqiu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory of Oral Diseases of Jiangsu Province and Stomatological School of Nanjing Medical University, Nanjing, Jiangsu, China. yujinhua@njmu.edu.cn.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Yu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation / Q000502:physiology*; D003817:Dentition; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D012038:Regeneration / Q000502:physiology
chemical_list: D004967:Estrogens