title: Hyperbilirubinemia in Preterm Neonates.
abstract: Preterm neonates with increased bilirubin production loads are more likely to sustain adverse outcomes due to either neurotoxicity or overtreatment with phototherapy and/or exchange transfusion. Clinicians should rely on expert consensus opinions to guide timely and effective interventions until there is better evidence to refine bilirubin-induced neurologic dysfunction or benefits of bilirubin. In this article, we review the evolving evidence for bilirubin-induced brain injury in preterm infants and highlight the clinical approaches that minimize the risk of bilirubin neurotoxicity.
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford Children's Health, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: bhutani@stanford.edu.
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Bhutani
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford Children's Health, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Wong
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford Children's Health, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: David K
authors.initials: DK
authors.lastname: Stevenson
mesh_terms: D005865:Gestational Age; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000150:complications / Q000517:prevention & control* / Q000628:therapy; D007231:Infant, Newborn; D007234:Infant, Premature; D007647:Kernicterus / Q000209:etiology / Q000517:prevention & control*; D010789:Phototherapy / Q000379:methods*; D018570:Risk Assessment; D013997:Time Factors
keywords: Antioxidant properties; BIND; Bilirubin; Photosensitivity; Reactive oxygen species