title: Prospective Assessment of Correlation between US Acoustic Radiation Force Impulse and MR Elastography in a Pediatric Population: Dispersion of US Shear-Wave Speed Measurement Matters.
abstract: Purpose To evaluate the correlation between ultrasonographic (US) point shear-wave elastography (SWE) and magnetic resonance (MR) elastography liver shear-wave speed (SWS) measurements in a pediatric population and to determine if US data dispersion affects this relationship. Materials and Methods Institutional review board approval was obtained for this HIPAA-compliant investigation; informed consent and patient assent (as indicated) were obtained. Patients (age range, 0-21 years) undergoing clinical liver MR elastography between July 2014 and November 2015 were prospectively enrolled. Patients underwent two-dimensional gradient-recalled-echo 1.5-T MR elastography with point SWE performed immediately before or immediately after MR elastography. Spearman rank correlation coefficients were calculated to assess the relationship and agreement between point SWE and MR elastography SWS measurements. Uni- and multivariate logistic regression were performed to identify predictors of US data dispersion, with the best multivariate model selected based on Akaike information criterion. Results A total of 55 patients (24 female) were enrolled (mean age, 14.0 years ± 3.9 (standard deviation) (range, 3.5-21.4 years). There was fair correlation between point SWE and MR elastography SWS values for all patients (ρ = 0.33, P = .016). Correlation was substantial, however, when including only patients with minimal US data dispersion (n = 26, ρ = 0.61, P = .001). Mean body mass index (BMI) was significantly lower in patients with minimal US data dispersion than in those with substantial US data dispersion (25.4 kg/m2± 7.8 vs 32.3 kg/m2± 8.3, P = .003). At univariate analysis, BMI (odds ratio, 1.12; 95% confidence interval [CI]: 1.03, 1.21; P = .006) and abdominal wall thickness (odds ratio, 2.50; 95% CI: 1.32, 4.74; P = .005) were significant predictors of US data dispersion. In the best multivariate model, BMI was the only significant predictor (odds ratio, 1.11; 95% CI: 1.03, 1.20; P = .009). Conclusion Point SWE and MR elastography liver SWS measurements correlate well in patients with a BMI of less than 30 kg/m2and minimal US data dispersion; increasing US data dispersion is directly related to a higher BMI.©RSNA, 2016.
authors.affiliation: From the Department of Radiology (A.T.T., J.R.D., S.S., A.D.M.) and Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics (S.X., R.K.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3039; University of Cincinnati College of Medicine, Cincinnati, Ohio (G.S.); Nemours Children's Health System, Nemours Children's Hospital, Orlando, Fla (D.J.P.); University of Central Florida College of Medicine, Orlando, Fla (D.J.P.); and Florida State University College of Medicine, Orlando, Fla (D.J.P.).
authors.forename: Andrew T
authors.identifier: http://orcid.org/0000-0003-1431-4054
authors.initials: AT
authors.lastname: Trout
authors.affiliation: From the Department of Radiology (A.T.T., J.R.D., S.S., A.D.M.) and Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics (S.X., R.K.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3039; University of Cincinnati College of Medicine, Cincinnati, Ohio (G.S.); Nemours Children's Health System, Nemours Children's Hospital, Orlando, Fla (D.J.P.); University of Central Florida College of Medicine, Orlando, Fla (D.J.P.); and Florida State University College of Medicine, Orlando, Fla (D.J.P.).
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Dillman
authors.affiliation: From the Department of Radiology (A.T.T., J.R.D., S.S., A.D.M.) and Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics (S.X., R.K.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3039; University of Cincinnati College of Medicine, Cincinnati, Ohio (G.S.); Nemours Children's Health System, Nemours Children's Hospital, Orlando, Fla (D.J.P.); University of Central Florida College of Medicine, Orlando, Fla (D.J.P.); and Florida State University College of Medicine, Orlando, Fla (D.J.P.).
authors.forename: Stavra
authors.initials: S
authors.lastname: Xanthakos
authors.affiliation: From the Department of Radiology (A.T.T., J.R.D., S.S., A.D.M.) and Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics (S.X., R.K.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3039; University of Cincinnati College of Medicine, Cincinnati, Ohio (G.S.); Nemours Children's Health System, Nemours Children's Hospital, Orlando, Fla (D.J.P.); University of Central Florida College of Medicine, Orlando, Fla (D.J.P.); and Florida State University College of Medicine, Orlando, Fla (D.J.P.).
authors.forename: Rohit
authors.initials: R
authors.lastname: Kohli
authors.affiliation: From the Department of Radiology (A.T.T., J.R.D., S.S., A.D.M.) and Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics (S.X., R.K.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3039; University of Cincinnati College of Medicine, Cincinnati, Ohio (G.S.); Nemours Children's Health System, Nemours Children's Hospital, Orlando, Fla (D.J.P.); University of Central Florida College of Medicine, Orlando, Fla (D.J.P.); and Florida State University College of Medicine, Orlando, Fla (D.J.P.).
authors.forename: Garrett
authors.initials: G
authors.lastname: Sprague
authors.affiliation: From the Department of Radiology (A.T.T., J.R.D., S.S., A.D.M.) and Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics (S.X., R.K.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3039; University of Cincinnati College of Medicine, Cincinnati, Ohio (G.S.); Nemours Children's Health System, Nemours Children's Hospital, Orlando, Fla (D.J.P.); University of Central Florida College of Medicine, Orlando, Fla (D.J.P.); and Florida State University College of Medicine, Orlando, Fla (D.J.P.).
authors.forename: Suraj
authors.identifier: http://orcid.org/0000-0002-8821-0971
authors.initials: S
authors.lastname: Serai
authors.affiliation: From the Department of Radiology (A.T.T., J.R.D., S.S., A.D.M.) and Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics (S.X., R.K.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3039; University of Cincinnati College of Medicine, Cincinnati, Ohio (G.S.); Nemours Children's Health System, Nemours Children's Hospital, Orlando, Fla (D.J.P.); University of Central Florida College of Medicine, Orlando, Fla (D.J.P.); and Florida State University College of Medicine, Orlando, Fla (D.J.P.).
authors.forename: Alana D
authors.initials: AD
authors.lastname: Mahley
authors.affiliation: From the Department of Radiology (A.T.T., J.R.D., S.S., A.D.M.) and Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics (S.X., R.K.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3039; University of Cincinnati College of Medicine, Cincinnati, Ohio (G.S.); Nemours Children's Health System, Nemours Children's Hospital, Orlando, Fla (D.J.P.); University of Central Florida College of Medicine, Orlando, Fla (D.J.P.); and Florida State University College of Medicine, Orlando, Fla (D.J.P.).
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Podberesky
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011446:Prospective Studies; D055815:Young Adult