title: Nutrigenomics and its Impact on Life Style Associated Metabolic Diseases.
abstract: Post-human genome revelation observes the emergence of 'Nutigenomics' as one of the exciting scientific advancement influencing mankind around the world. Food or more precisely 'nutrition' has the major impact in defining the cause-response interaction between nutrient (diet) and human health. In addition to substantial understanding of nutrition-human-health interaction, bases of 'nutrigenomic' development foster on advent in transcriptomics, genomics, proteomics and metabolomics as well as insight into food as health supplement. Interaction of selected nutrient with associated genes in specific organ or tissue necessary to comprehend that how individual's genetic makeup (DNA transcribed into mRNA and then to proteins) respond to particular nutrient. It provided new opportunities to incorporate natural bioactive compounds into food for specific group of people with similar genotype. As inception of diabetes associated with change in gene expression of, not limited to, protein kinase B, insulin receptor, duodenal homeobox and glucokinase, thus, targeting such proteins by modifying or improving the nutritional availability or uptake may help to devise novel food, supplements, or nutraceuticals. In this article, various aspects of R&D in nutrigenomics are reviewed to ascertain its impact on human health, especially with life-style associated diseases.
authors.affiliation: Department of Biotechnology, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176 061 (HP), India;; Academy of Scientific and Innovative Research, CSIR-Institute of Himalayan Bioresource Technology, Palampur176 061 (HP), India.
authors.forename: Shalika
authors.initials: S
authors.lastname: Rana
authors.affiliation: Pharmacology and Toxicology Lab, Department of Food Nutraceuticals and Quality Control, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176 061 (HP), India;; Academy of Scientific and Innovative Research, CSIR-Institute of Himalayan Bioresource Technology, Palampur176 061 (HP), India.
authors.forename: Shiv
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Biotechnology, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176 061 (HP), India;
authors.forename: Nikita
authors.initials: N
authors.lastname: Rathore
authors.affiliation: Pharmacology and Toxicology Lab, Department of Food Nutraceuticals and Quality Control, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176 061 (HP), India;; Academy of Scientific and Innovative Research, CSIR-Institute of Himalayan Bioresource Technology, Palampur176 061 (HP), India.
authors.forename: Yogendra
authors.initials: Y
authors.lastname: Padwad
authors.affiliation: Department of Biotechnology, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176 061 (HP), India;; Academy of Scientific and Innovative Research, CSIR-Institute of Himalayan Bioresource Technology, Palampur176 061 (HP), India.
authors.forename: Shashi
authors.initials: S
authors.lastname: Bhushana
keywords: Cardiovascular; Diabetes; Ethics; Inflammation; Nutrient; Nutrigenomics; Protein.