title: Medicinal Plants and Natural Products as Potential Sources for Antiparkinson Drugs.
abstract: Parkinson's disease is a progressive neurodegenerative dysfunction characterized by the loss of pigmented dopaminergic neurons of the nigrostriatal system with a consequent dopamine decrease. The reduction of dopamine levels produces neuronal damage, depigmentation of the substantia nigra, and the presence of intracellular inclusions in dopaminergic neurons. Treatments for Parkinson's disease aim for improving these motor symptoms by increasing the dopaminergic signal in the striatum with levodopa in combination with enzyme inhibitors or anticholinergic drugs. Nevertheless, natural products can act as neuroprotective agents by reducing the progression of the disease and the inflammatory process.In the present review, we have compiled data on the principal medicinal plants and natural products as potential antiparkinsonian agents. They act by different mechanisms, such as the inhibition of α-synuclein condensation, reduction of oxidative stress and neuro-inflammation, increase of dopaminergic neurons survival, or the blockade of the A2 A receptor.
authors.affiliation: Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain.
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Ríos
authors.affiliation: Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain.
authors.forename: María
authors.initials: M
authors.lastname: Onteniente
authors.affiliation: Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain.
authors.forename: Dolores
authors.initials: D
authors.lastname: Picazo
authors.affiliation: Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot (Valencia), Spain.
authors.forename: María-Carmen
authors.initials: MC
authors.lastname: Montesinos
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D001688:Biological Products / Q000627:therapeutic use*; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000978:Antiparkinson Agents; D001688:Biological Products; D010936:Plant Extracts