title: 3D Bioprinting for Vascularized Tissue Fabrication.
abstract: 3D bioprinting holds remarkable promise for rapid fabrication of 3D tissue engineering constructs. Given its scalability, reproducibility, and precise multi-dimensional control that traditional fabrication methods do not provide, 3D bioprinting provides a powerful means to address one of the major challenges in tissue engineering: vascularization. Moderate success of current tissue engineering strategies have been attributed to the current inability to fabricate thick tissue engineering constructs that contain endogenous, engineered vasculature or nutrient channels that can integrate with the host tissue. Successful fabrication of a vascularized tissue construct requires synergy between high throughput, high-resolution bioprinting of larger perfusable channels and instructive bioink that promotes angiogenic sprouting and neovascularization. This review aims to cover the recent progress in the field of 3D bioprinting of vascularized tissues. It will cover the methods of bioprinting vascularized constructs, bioink for vascularization, and perspectives on recent innovations in 3D printing and biomaterials for the next generation of 3D bioprinting for vascularized tissue fabrication.
authors.affiliation: Bioengineering Department, Clemson University, Clemson, SC, 29634, USA.
authors.forename: Dylan
authors.initials: D
authors.lastname: Richards
authors.affiliation: Bioengineering Department, Clemson University, Clemson, SC, 29634, USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Jia
authors.affiliation: Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, 29425, USA.|Department of Surgery, Medical University of South Carolina, Charleston, SC, 29425, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Yost
authors.affiliation: Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, 29425, USA.
authors.forename: Roger
authors.initials: R
authors.lastname: Markwald
authors.affiliation: Bioengineering Department, Clemson University, Clemson, SC, 29634, USA. mei@clemson.edu.|Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, 29425, USA. mei@clemson.edu.
authors.forename: Ying
authors.initials: Y
authors.lastname: Mei
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D001807:Blood Vessel Prosthesis; D006801:Humans; D066330:Printing, Three-Dimensional; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods*
chemical_list: D001672:Biocompatible Materials
keywords: 3D printing; Bioink; Bioprinting; Tissue engineering; Vascularization