title: Ménière's Disease and Underlying Medical and Mental Conditions: Towards Factors Contributing to the Disease.
abstract: OBJECTIVE
  To investigate the relation of Ménière's disease (MD) with medical comorbidity or mental conditions.
  
  
  METHODS
  Demographic data, medical and mental comorbidities were retrospectively collected and compared from 3 groups of 30 patients each: a group with patients with definite MD, a second one with patients with vestibulopathies other than MD (non-Ménière's vertigo, NMV) and a third one with patients without any vestibular symptoms (control). The level of significance was set at 0.05.
  
  
  RESULTS
  The prevalence of mental conditions was 26.7, 23.3 and 6.7% for the MD, the NMV and the control group, respectively. Medical comorbidity was found in 80% of patients in the MD, 63% in the NMV and 20% in the control group. Arthritis was encountered in 8 patients with MD, 3 with NMV and none from the control group. The differences in prevalence of mental disease, comorbidities and arthritis between the MD and the control group were statistically significant (p = 0.02, p < 0.001 and p = 0.008, respectively).
  
  
  CONCLUSIONS
  Psychological conditions play an important role in patients with MD. The significantly increased prevalence of arthritis in the MD group suggests an inflammatory/autoimmune background as a contributing factor to the disease.
authors.affiliation: Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, UK.
authors.forename: Shwan
authors.initials: S
authors.lastname: Mohamed
authors.forename: Imran
authors.initials: I
authors.lastname: Khan
authors.forename: Stamatina
authors.initials: S
authors.lastname: Iliodromiti
authors.forename: Margaret
authors.initials: M
authors.lastname: Gaggini
authors.forename: Georgios
authors.initials: G
authors.lastname: Kontorinis
mesh_terms: D000328:Adult; D000368:Aged; D001007:Anxiety / Q000150:complications; D001168:Arthritis / Q000150:complications*; D016022:Case-Control Studies; D003863:Depression / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications* / Q000523:psychology; D001523:Mental Disorders / Q000150:complications*; D008875:Middle Aged; D012189:Retrospective Studies; D017678:Sex Distribution; D015837:Vestibular Diseases / Q000150:complications*