title: Adverse effects of the SSRI antidepressant sertraline on early life stages of marine invertebrates.
abstract: Widespread contamination of coastal environments by emerging compounds includes low concentrations of pharmaceuticals. These pollutants are not currently incorporated in monitoring programs despite their effects on non-target organisms are very little documented. Among the selective serotonin reuptake inhibitor (SSRI) antidepressants, sertraline (SRT) is one of the most prescribed globally. In this work, earlier life stages of Amphibalanus amphitrite, Brachionus plicatilis and Mytilus galloprovincialis were exposed to environmental concentrations of SRT in order to study both sub-lethal and lethal responses in 24/48 h-tests. Low concentrations of SRT altered significantly swimming behavior in A. amphitrite and B. plicatilis giving 48 h-EC50(μg/L) of 113.88 and 282.23, respectively whereas higher values were observed for mortality and immobilization. EC50embryotoxicity with M. galloprovincialis was 206.80 μg/L. This work add new data about SRT ecotoxicity on marine invertebrates and confirms the applicability of behavioral endpoints to evaluate the environmental impact of antidepressants in marine organisms.
authors.affiliation: Istituto di Scienze Marine, Consiglio Nazionale delle Ricerche (ISMAR-CNR), Via De Marini 6, 16149, Genova, Italy. Electronic address: noelia.estevezcalvar@ge.ismar.cnr.it.
authors.forename: Noelia
authors.initials: N
authors.lastname: Estévez-Calvar
authors.affiliation: Department of Earth, Environment and Life Sciences (DISTAV), Università degli Studi di Genova, Corso Europa 26, 16132, Genova, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Canesi
authors.affiliation: Department of Earth, Environment and Life Sciences (DISTAV), Università degli Studi di Genova, Corso Europa 26, 16132, Genova, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Montagna
authors.affiliation: Istituto di Scienze Marine, Consiglio Nazionale delle Ricerche (ISMAR-CNR), Via De Marini 6, 16149, Genova, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Faimali
authors.affiliation: Istituto di Scienze Marine, Consiglio Nazionale delle Ricerche (ISMAR-CNR), Via De Marini 6, 16149, Genova, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Piazza
authors.affiliation: Istituto di Scienze Marine, Consiglio Nazionale delle Ricerche (ISMAR-CNR), Arsenale Tesa 104, Castello 2737/F, 30122, Venezia, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Garaventa
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000633:toxicity*; D059001:Aquatic Organisms / Q000502:physiology*; D007448:Invertebrates; D008018:Life Cycle Stages / Q000187:drug effects*; D049878:Mytilus; D012403:Rotifera; D020280:Sertraline / Q000633:toxicity*; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000928:Antidepressive Agents; D014874:Water Pollutants, Chemical; D020280:Sertraline
keywords: Antidepressants; Behavior; Developmental abnormalities; Ecotoxicology; Invertebrates; Marine organisms; Sertraline; Toxicity