title: Targeted lipid-polyaniline hybrid nanoparticles for photoacoustic imaging guided photothermal therapy of cancer.
abstract: Designing a targeted and versatile photothermal agent for the integration of precise diagnosis and effective photothermal treatment of tumors is desirable but remains a great challenge. In this study, folic acid ligand conjugated lipid-coated polyaniline hybrid nanoparticles (FA-Lipid-PANI NPs) were successfully fabricated by a distinctive technology. The obtained hybrid FA-Lipid-PANI NPs with small size exhibited not only significant photoacoustic (PA) imaging signals, but also a remarkable photothermal effect for tumor treatment. With PA imaging and photothermal therapy (PTT), the tumor could be accurately positioned and thoroughly eradicated in vivo after intravenous injection of FA-Lipid-PANI NPs. These multifunctional nanoparticles could play an important role in simultaneously facilitating imaging and PTT to achieve better therapeutic efficacy.
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, People's Republic of China.
authors.forename: Jinping
authors.initials: J
authors.lastname: Wang
authors.forename: Ran
authors.initials: R
authors.lastname: Yan
authors.forename: Fang
authors.initials: F
authors.lastname: Guo
authors.forename: Meng
authors.initials: M
authors.lastname: Yu
authors.forename: Fengping
authors.initials: F
authors.lastname: Tan
authors.forename: Nan
authors.initials: N
authors.lastname: Li
mesh_terms: D000814:Aniline Compounds; D006801:Humans; D008055:Lipids; D053758:Nanoparticles; D009369:Neoplasms; D061088:Photoacoustic Techniques; D010789:Phototherapy
chemical_list: D000814:Aniline Compounds; D008055:Lipids; C416807:polyaniline