title: Angiogenesis-related biomarkers (sFlt-1/PlGF) in placental mesenchymal dysplasia.
abstract: Determination of the soluble fms-like tyrosine kinase-1 to placental growth factor ratio (sFlt-1/PlGF) in the maternal serum is expected to aid in the monitoring and decision-making process of women at risk for placental dysfunction. We report two cases of placental mesenchymal dysplasia (PMD) with sFlt-1/PlGF correlation. The first case is a dichorionic twin pregnancy with one fetus affected by PMD and Beckwith-Wiedemann syndrome in which a high value of sFlt-1/PlGF was found, coinciding with acute maternal and fetal wellbeing decline at 31 weeks. The second case corresponds to a singleton pregnancy diagnosed of PMD with normal sFlt-1/PlGF and favorable outcome.
authors.affiliation: a Fetal Medicine Unit-SAMID , Department of Obstetrics and Gynaecology and.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Herraiz
authors.affiliation: a Fetal Medicine Unit-SAMID , Department of Obstetrics and Gynaecology and.
authors.forename: Elisa
authors.initials: E
authors.lastname: Simón
authors.affiliation: a Fetal Medicine Unit-SAMID , Department of Obstetrics and Gynaecology and.|b Department of Pathology , Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid , Madrid , Spain.
authors.forename: Óscar
authors.initials: Ó
authors.lastname: Toldos
authors.affiliation: a Fetal Medicine Unit-SAMID , Department of Obstetrics and Gynaecology and.|b Department of Pathology , Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid , Madrid , Spain.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Rodríguez
authors.affiliation: a Fetal Medicine Unit-SAMID , Department of Obstetrics and Gynaecology and.
authors.forename: Paula I
authors.initials: PI
authors.lastname: Gómez-Arriaga
authors.affiliation: a Fetal Medicine Unit-SAMID , Department of Obstetrics and Gynaecology and.
authors.forename: Alberto
authors.initials: A
authors.lastname: Galindo
mesh_terms: D000328:Adult; D001506:Beckwith-Wiedemann Syndrome / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D004200:Diseases in Twins / Q000097:blood / Q000473:pathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D018919:Neovascularization, Physiologic; D066087:Perinatal Death; D010922:Placenta Diseases / Q000097:blood* / Q000175:diagnosis; D000072483:Placenta Growth Factor / Q000097:blood; D011247:Pregnancy; D059285:Pregnancy, Twin; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood
chemical_list: D015415:Biomarkers; C000608036:PGF protein, human; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1
keywords: Angiogenic factors; Beckwith–Wiedemann syndrome; intrauterine growth restriction; placental dysfunction; placental growth factor; soluble fms-like tyrosine kinase-1