title: Sequential Changes of Vitamin D Level and Parathyroid Hormone After Kidney Transplantation.
abstract: BACKGROUND
  Numerous studies have shown that vitamin D deficiency is common in end stage renal disease patients. However, change of the vitamin D deficiency after kidney transplantation is not fully understood.
  
  
  METHODS
  Twenty-five kidney transplant (KT) recipients with serum 25-hydroxyvitamin D (25D) level, 1,25-dihydroxyvitamin D (1,25D) level, parathyroid hormone (PTH) level before and 6, 12, and 24 months after transplantation were reviewed.
  
  
  RESULTS
  Serum PTH level and 1,25D level showed significant changes at 6 months after transplantation, but did not show further change at 12 months. 25D level did not increase within 6 months after transplantation. However, 25D level showed gradual increase after 6 months. The proportion of recipients with 25D deficiency (<10 ng/mL) was 68%, 40%, and 28% before, 12 months after, and 24 months after transplantation, respectively. Patients with vitamin D deficiency at 24 month were younger at transplantation (37.7 ± 9.6 y vs 48.2 ± 8.0 y; P = .029) and had lower 25D level before transplantation (7.96 ± 1.74 ng/mL vs 10.59 ± 4.35 ng/mL; P = .041).
  
  
  CONCLUSIONS
  25D deficiency is persistent in almost kidney transplant recipients even 12 months after transplantation, although serum PTH levels decrease and serum 25D levels increase after transplantation.
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Inchon, Republic of Korea.
authors.forename: H H
authors.initials: HH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Inchon, Republic of Korea.
authors.forename: A J
authors.initials: AJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Inchon, Republic of Korea. Electronic address: godad@gachon.ac.kr.
authors.forename: H
authors.initials: H
authors.lastname: Ro
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Inchon, Republic of Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Inchon, Republic of Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Chang
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Inchon, Republic of Korea.
authors.forename: W
authors.initials: W
authors.lastname: Chung
authors.affiliation: Department of Surgery, Gachon University Gil Medical Center, Inchon, Republic of Korea.
authors.forename: Y H
authors.initials: YH
authors.lastname: Park
mesh_terms: D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D011183:Postoperative Complications; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000209:etiology
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D