title: Criteria, prevalence, and phenotypes of polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS) is a highly prevalent disorder effecting reproductive-aged women worldwide. This article addresses the evolution of the criteria used to diagnosis PCOS; reviews recent advances in the phenotypic approach, specifically in the context of the extended Rotterdam criteria; discusses limitations of the current criteria used to diagnosis, particularly when studying adolescents and women in the peri- and postmenopause; and describes significant strides made in understanding the epidemiology of PCOS. This review recognizes that although there is a high prevalence of PCOS, there is increased variability when using Rotterdam 2003 criteria, owing to limitations in population sampling and approaches used to define PCOS phenotypes. Last, we discuss the distribution of PCOS phenotypes, their morbidity, and the role that referral bias plays in the epidemiology of this syndrome.
authors.affiliation: Department of Obstetrics and Gynecology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia; Medical Company IDK, Samara, Russian Federation; Department of Reproductive Health Protection, Scientific Center of Family Health and Human Reproduction, Irkutsk, Russian Federation. Electronic address: dlizneva@gru.edu.
authors.forename: Daria
authors.initials: D
authors.lastname: Lizneva
authors.affiliation: Department of Reproductive Health Protection, Scientific Center of Family Health and Human Reproduction, Irkutsk, Russian Federation.
authors.forename: Larisa
authors.initials: L
authors.lastname: Suturina
authors.affiliation: Department of Obstetrics and Gynecology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia.
authors.forename: Walidah
authors.initials: W
authors.lastname: Walker
authors.affiliation: Department of Obstetrics and Gynecology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia.
authors.forename: Soumia
authors.initials: S
authors.lastname: Brakta
authors.affiliation: Department of Obstetrics and Gynecology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia.
authors.forename: Larisa
authors.initials: L
authors.lastname: Gavrilova-Jordan
authors.affiliation: Department of Obstetrics and Gynecology, Medical College of Georgia, Georgia Regents University, Augusta, Georgia; Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, Georgia.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Azziz
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D005260:Female; D006801:Humans; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D015995:Prevalence; D012017:Referral and Consultation; D012098:Reproduction; D060728:Reproductive Health; D012307:Risk Factors; D015983:Selection Bias; D055815:Young Adult
keywords: Phenotypes; polycystic ovary syndrome; prevalence; referral bias