title: Reduced oxygen utilization in septic shock: disorder or adaptation?
abstract: A fall in oxygen utilization during septic or endotoxic shock is thought to reflect circulatory hypoxia or mitochondrial dysfunction, but these pathology-oriented hypotheses do not explain all clinical observations. Here we discuss an alternative hypothesis of how oxygen utilization could fall as the result of a physiological thermometabolic adaptation.
authors.affiliation: Department of Immunology; Institute of Biomedical Sciences; University of São Paulo ; São Paulo, SP Brazil.
authors.forename: Alexandre A
authors.initials: AA
authors.lastname: Steiner
keywords: LPS; critical care oxygen; fever; hypothermia; hypoxia; metabolism; sepsis; temperature; thermogenesis