title: Stereoselective Rh-Catalyzed Hydrogenative Desymmetrization of Achiral Substituted 1,4-Dienes.
abstract: Highly efficient catalytic stereoselective hydrogenative desymmetrization reactions mediated by rhodium complexes derived from enantiopure phosphine-phosphite (P-OP) ligands are described. The highest performing ligand, which contains a TADDOL-derived phosphite fragment [TADDOL = (2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol)], presented excellent catalytic properties for the desymmetrization of a set of achiral 1,4-dienes, providing access to the selective formation of a variety of enantioenriched secondary and tertiary alcohols (six examples, up to 92% ee).
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ) , Av Països Catalans, 16, 43007 Tarragona, Spain.|The Barcelona Institute of Science and Technology , Av Països Catalans, 16, 43007 Tarragona, Spain.
authors.forename: Héctor
authors.initials: H
authors.lastname: Fernández-Pérez
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ) , Av Països Catalans, 16, 43007 Tarragona, Spain.|The Barcelona Institute of Science and Technology , Av Països Catalans, 16, 43007 Tarragona, Spain.
authors.forename: Joan R
authors.initials: JR
authors.lastname: Lao
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ) , Av Països Catalans, 16, 43007 Tarragona, Spain.|Catalan Institution for Research and Advanced Studies (ICREA) , P. Lluís Companys, 23, 08010 Barcelona, Spain.|The Barcelona Institute of Science and Technology , Av Països Catalans, 16, 43007 Tarragona, Spain.
authors.forename: Anton
authors.initials: A
authors.lastname: Vidal-Ferran