title: The Connections Among Autophagy, Inflammasome and Mitochondria.
abstract: The molecular crosstalk between inflammation and autophagy is an emerging field of research that is essential for the understanding of multicellular organism homeostasis and how these processes influence a variety of pathological conditions.
  
  
  
  In this review, we briefly describe the relationship between autophagy and inflammasome activation. The central role that mitochondria play in both cellular processes is also discussed.
  
  
  
  Inflammasome and autophagy often modulate each other by common inhibitory mechanisms that are controlled by different input pathways. Thus, inflammasome components coordinate autophagy and autophagy regulates inflammasome activation, making the balance between both processes a fundamental player in cellular homeostasis.
authors.forename: Isabel
authors.initials: I
authors.lastname: de Lavera
authors.forename: Ana Delgado
authors.initials: AD
authors.lastname: Pavon
authors.forename: Marina Villanueva
authors.initials: MV
authors.lastname: Paz
authors.forename: Manuel
authors.initials: M
authors.lastname: Oropesa-Avila
authors.forename: Mario
authors.initials: M
authors.lastname: de la Mata
authors.forename: Elizabet
authors.initials: E
authors.lastname: Alcocer-Gomez
authors.forename: Juan
authors.initials: J
authors.lastname: Garrido-Maraver
authors.forename: David
authors.initials: D
authors.lastname: Cotan
authors.forename: Monica
authors.initials: M
authors.lastname: Alvarez-Cordoba
authors.affiliation: Centro Andaluz de Biologia, del Desarrollo [CABD]. Universidad Pablo de Olavide-Consejo Superior de 
  Investigaciones Cientificas. Carretera de Utrera Km 1, Sevilla 41013, Spain.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Sanchez-Alcazar
mesh_terms: D001343:Autophagy; D016923:Cell Death; D006801:Humans; D058847:Inflammasomes / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology*
chemical_list: D058847:Inflammasomes
keywords: Autophagy; NLRP3; ROS; cytokines; inflammasome; mitochondria