title: Growth and Metabolism in Children Born Small for Gestational Age.
abstract: Most children born SGA show spontaneous catch-up growth to a normal weight and height above -2 SDS; however, 10% remain short. GH treatment improves adult height and has positive effects on body composition, blood pressure and serum lipids. At 6.5 years after stopping GH treatment, body composition, blood pressure, and lipid levels are similar to untreated short SGA adults indicating that GH-induced catch-up in height has no unfavorable effects on metabolic health. GH-induced reduction in insulin sensitivity is reversible after stopping GH. It remains to be elucidated how metabolic health develops when these subjects become older.
authors.affiliation: Dutch Growth Research Foundation, P.O. box 23068, 3001 KB Rotterdam, The Netherlands; Erasmus University Medical Center, Sophia Children's Hospital, P.O. Box 2060, 3000 CB Rotterdam, The Netherlands.
authors.forename: Manouk
authors.initials: M
authors.lastname: van der Steen
authors.affiliation: Dutch Growth Research Foundation, P.O. box 23068, 3001 KB Rotterdam, The Netherlands; Erasmus University Medical Center, Sophia Children's Hospital, P.O. Box 2060, 3000 CB Rotterdam, The Netherlands. Electronic address: a.hokken@erasmusmc.nl.
authors.forename: Anita C S
authors.initials: AC
authors.lastname: Hokken-Koelega
mesh_terms: D001794:Blood Pressure; D001823:Body Composition; D001827:Body Height; D002648:Child; D002657:Child Development; D005865:Gestational Age; D006130:Growth Disorders / Q000188:drug therapy; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000254:growth & development* / Q000378:metabolism*; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood
chemical_list: D008055:Lipids; D019382:Human Growth Hormone
keywords: Growth; Growth hormone treatment; Metabolic health; Small for gestational age