title: A clinical trial to validate event-related potential markers of Alzheimer's disease in outpatient settings.
abstract: BACKGROUND
  We investigated whether event-related potentials (ERP) collected in outpatient settings and analyzed with standardized methods can provide a sensitive and reliable measure of the cognitive deficits associated with early Alzheimer's disease (AD).
  
  
  METHODS
  A total of 103 subjects with probable mild AD and 101 healthy controls were recruited at seven clinical study sites. Subjects were tested using an auditory oddball ERP paradigm.
  
  
  RESULTS
  Subjects with mild AD showed lower amplitude and increased latency for ERP features associated with attention, working memory, and executive function. These subjects also had decreased accuracy and longer reaction time in the target detection task associated with the ERP test.
  
  
  CONCLUSIONS
  Analysis of ERP data showed significant changes in subjects with mild AD that are consistent with the cognitive deficits found in this population. The use of an integrated hardware/software system for data acquisition and automated data analysis methods make administration of ERP tests practical in outpatient settings.
authors.affiliation: Neuronetrix, Louisville, KY, USA.
authors.forename: Marco
authors.initials: M
authors.lastname: Cecchi
authors.affiliation: Neuronetrix, Louisville, KY, USA.
authors.forename: Dennis K
authors.initials: DK
authors.lastname: Moore
authors.affiliation: Department of Neurology, Nova Southeastern University, Fort Lauderdale, FL, USA.
authors.forename: Carl H
authors.initials: CH
authors.lastname: Sadowsky
authors.affiliation: Department of Psychology, Williams College, Williamstown, MA, USA.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Solomon
authors.affiliation: Departments of Psychiatry and Medicine, Duke Medicine and Duke Institute for Brain Sciences, Durham, NC, USA.
authors.forename: P Murali
authors.initials: PM
authors.lastname: Doraiswamy
authors.affiliation: Department of Neurology, University of Kentucky, Lexington, KY, USA.
authors.forename: Charles D
authors.initials: CD
authors.lastname: Smith
authors.affiliation: Department of Neurology, University of Kentucky, Lexington, KY, USA.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Jicha
authors.affiliation: Department of Cognitive & Behavioral Neurology, VA Boston Healthcare System, Boston, MA, USA.
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Budson
authors.affiliation: Departments of Psychiatry and Neurology, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Arnold
authors.affiliation: Neuronetrix, Louisville, KY, USA.
authors.forename: Kalford C
authors.initials: KC
authors.lastname: Fadem
keywords: Automated ERP data analysis; Early stage Alzheimer's disease; Event-related potentials; Multicenter clinical trial; Oddball paradigm; Outpatient settings