title: Dual-Energy CT Characteristics of Parathyroid Adenomas on 25-and 55-Second 4D-CT Acquisitions: Preliminary Experience.
abstract: OBJECTIVE
  The objective of this study was to compare the dual-energy computed tomography (CT) characteristics of parathyroid adenomas (PAs), thyroid tissue, and lymph nodes (LNs) and assess whether the spectral information can improve distinction of these tissues.
  
  
  METHODS
  Dual-energy CT scans from 20 patients with pathologically proven PAs were retrospectively evaluated, identifying 19 eligible PAs and region of interest analysis used for spectral characterization.
  
  
  RESULTS
  There was a significant difference in multiple spectral parameters between PAs, LNs, and the thyroid gland (P < 0.05-0.0001). The greatest difference in spectral characteristics of PAs compared with that of LNs was on the 25-second acquisition, whereas the 55-second acquisition was better for distinguishing PAs from the thyroid gland.
  
  
  CONCLUSIONS
  Four-dimensional CT acquired in dual-energy CT mode has the potential to further enhance diagnostic accuracy for PA identification on individual phases of the perfusion study.
authors.affiliation: From the *Department of Radiology, †Segal Cancer Centre, ‡Lady Davis Institute for Medical Research, and §Department of Otolaryngology-Head and Neck Surgery, Jewish General Hospital, McGill University, Montreal, Quebec, Canada; and ‖Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC.
authors.forename: Reza
authors.initials: R
authors.lastname: Forghani
authors.forename: Michael
authors.initials: M
authors.lastname: Roskies
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Liu
authors.forename: Xianming
authors.initials: X
authors.lastname: Tan
authors.forename: Alex
authors.initials: A
authors.lastname: Mlynarek
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Payne
authors.forename: Jaykumar R
authors.initials: JR
authors.lastname: Nair
authors.forename: Michael P
authors.initials: MP
authors.lastname: Hier
authors.forename: Mark
authors.initials: M
authors.lastname: Levental
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D056973:Four-Dimensional Computed Tomography / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging*; D010865:Pilot Projects; D011829:Radiation Dosage; D000069079:Radiation Exposure / Q000032:analysis* / Q000517:prevention & control; D011856:Radiographic Image Enhancement / Q000379:methods; D015900:Radiography, Dual-Energy Scanned Projection / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity