title: The Pathologic Point of View of Laparoscopic Adrenalectomy in the Era of Radiologic Imaging: A Multicenter Retrospective Study.
abstract: OBJECTIVE
  This study aimed to determine if laparoscopic adrenalectomy (LA) is feasible for the treatment of adrenal malignancies and metastasis, and to review the final pathology findings in order to clarify the indications for surgery.
  
  
  METHODS
  The medical records of all patients that underwent LA at 3 university hospitals between January 1, 2008, and May 1, 2015, were retrospectively reviewed.
  
  
  RESULTS
  In total, 189 laparoscopic adrenalectomies were completed successfully. Mean duration of surgery was 79.3 ± 38.6 min and mean estimated intraoperative blood loss was 39.9 ml. Intraoperatively, 4 patients had major complications: spleen injury (n = 1), renal vein injury (n = 2) and diaphragm injury (n = 2). Histopathological examination showed that there were 20 different types of lesions. Surgical margins (SMs) were tumor free in 95.2% of the patients. Moreover, SMs were tumor free in all patients with adrenocortical carcinomas; however, positive margins were noted in 7 of 23 patients (30.4%) with malignant adrenal tumors.
  
  
  CONCLUSIONS
  The present findings support the use of laparoscopy for metastatic adrenal masses, despite a high positive margin rate. LA is a safe, feasible and cost-effective procedure for the management of benign and malignant adrenal masses.
authors.affiliation: Departments of Urology, School of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Senol
authors.initials: S
authors.lastname: Tonyali
authors.forename: Fatih
authors.initials: F
authors.lastname: Atac
authors.forename: Unsal
authors.initials: U
authors.lastname: Eroglu
authors.forename: Sertac
authors.initials: S
authors.lastname: Yazici
authors.forename: Ender
authors.initials: E
authors.lastname: Ozden
authors.forename: Sinan
authors.initials: S
authors.lastname: Sozen
authors.forename: Cenk Yücel
authors.initials: CY
authors.lastname: Bilen
mesh_terms: D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D000315:Adrenalectomy / Q000379:methods*; D018268:Adrenocortical Carcinoma / Q000000981:diagnostic imaging* / Q000556:secondary / Q000601:surgery*; D000328:Adult; D000368:Aged; D005240:Feasibility Studies; D006801:Humans; D010535:Laparoscopy; D008297:Male; D059146:Metastasectomy; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult