title: Characteristic manifestations of acute paint thinner-intoxicated children.
abstract: In this study, we evaluated the acute clinical and para-clinical abnormalities arising from paint thinner (PT) poisoning in children. Data were collected from 2008 to 2013, and sourced from the medical records of PT-intoxicated children and through questionnaires. A total of 42 children were enrolled in the study. The mean age was 37.2±2.4 months. The participants ranged from10 to 96 months of age; with a median age of 3 months; and a modal age of 24 months. The sex ratio in the study was 22 males (64.9%) to 20 females (35.1%). Clinical biochemistry results of participants revealed the significant presence of alkaline phosphatase (ALP, 569.25±151.58U/L), and lactate dehydrogenase (LDH, 576.14±164.97 IU/L). Arterial blood gas (ABG) analysis was also carried out. Chest X-ray predominantly revealed right side alveolar air space consolidation. These results confirmed hepatotoxicity and pneumonia in PT-intoxicated children. The study also revealed that positive outcomes were achieved in patients with early treatment and management. In addition, the current finding confirmed the timely transfer of the victim to the poisoning center.
authors.affiliation: Toxicological Research Center, Loghman-Hakim Hospital, Department of Clinical Toxicology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: khosrow.agin@yahoo.com.
authors.forename: Khosrow
authors.initials: K
authors.lastname: Agin
authors.affiliation: Toxicological Research Center, Loghman-Hakim Hospital, Department of Clinical Toxicology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Hassanian@sbmu.ac.ir.
authors.forename: Hossein
authors.initials: H
authors.lastname: Hassanian-Moghaddam
authors.affiliation: Toxicological Research Center, Loghman-Hakim Hospital, Department of Clinical Toxicology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: shadniatrc@sbmu.ac.ir.
authors.forename: Shahin
authors.initials: S
authors.lastname: Shadnia
authors.affiliation: Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: hamidrrt@yahoo.com.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Rahimi
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D001784:Blood Gas Analysis; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D010150:Paint; D011014:Pneumonia / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013902:Radiography, Thoracic; D012189:Retrospective Studies; D012997:Solvents / Q000633:toxicity*
chemical_list: D012997:Solvents; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase
keywords: Hepatotoxicity; Hydrocarbon; Hypoxemia; Paint thinner; Pneumonia