title: Evaluation of the effect of time on the distribution of zinc oxide nanoparticles in tissues of rats and mice: a systematic review.
abstract: To evaluate the time effect on the distribution of zinc oxide nanoparticles (ZnO NPs) in tissues from rats and mice, a search on the PubMed, Embase, SpringerLink, Scopus, Science Direct, Cochrane, CNKI, Wanfang, and vip databases up to September 2014 was performed, followed by screening, data extraction, and quality assessment. Thirteen studies were included. At 24 h, Zn content was mainly distributed in the liver, kidney, and lung. At ≥7 days, Zn content was mainly distributed in the liver, kidney, lung, and brain. ZnO NPs are readily deposited in tissues. Furthermore, as time increases, Zn content decreases in the liver and kidney, but increases in the brain.
authors.affiliation: Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, People's Republic of China.
authors.forename: Aijie
authors.initials: A
authors.lastname: Chen
authors.affiliation: Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, People's Republic of China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Feng
authors.affiliation: Medical Centre of Stomatology, The First Affiliated Hospital of Jinan University, 613 Huangpu Avenue West, Guangzhou, People's Republic of China.
authors.forename: Ting
authors.initials: T
authors.lastname: Sun
authors.affiliation: Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, People's Republic of China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health and Tropical Medicine, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, People's Republic of China.
authors.forename: Shengli
authors.initials: S
authors.lastname: An
authors.affiliation: Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, People's Republic of China. shaolongquan@smu.edu.cn.
authors.forename: Longquan
authors.initials: L
authors.lastname: Shao
mesh_terms: D000818:Animals; D007668:Kidney / Q000737:chemistry / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008168:Lung / Q000737:chemistry / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution; D015034:Zinc Oxide / Q000737:chemistry* / Q000493:pharmacokinetics*
chemical_list: D015034:Zinc Oxide