title: Dynamic lipid landscape of picornavirus replication organelles.
abstract: Picornavirus infection induces rapid reorganization of the cellular membrane architecture and appearance of novel membranous structures associated with the viral RNA replication and virion assembly-replication organelles. Recent studies significantly advanced our understanding of their lipid composition and cellular mechanisms involved in their development. Picornaviruses activate synthesis of both structural and signaling lipids and reroute cellular cholesterol trafficking pathways to create unique membranous domains favoring viral replication. Rapidly replicating picornaviruses rely on posttranslational activation and/or specific recruitment of cellular proteins rather than on modulation of expression of cellular genes to create favorable membrane microenvironment. At the same time picornaviruses demonstrate remarkable adaptability to changes in the lipid landscape which should be taken into account when developing novel antiviral strategies.
authors.affiliation: Department of Veterinary Medicine, University of Maryland, and Virginia-Maryland Regional College of Veterinary Medicine, College Park, MD 20742, United States. Electronic address: gbelov@umd.edu.
authors.forename: George A
authors.initials: GA
authors.lastname: Belov
mesh_terms: D002462:Cell Membrane / Q000737:chemistry / Q000502:physiology; D004261:DNA Replication; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D015388:Organelles / Q000737:chemistry* / Q000502:physiology / Q000648:ultrastructure; D010849:Picornaviridae / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D012367:RNA, Viral; D014779:Virus Replication
chemical_list: D008055:Lipids; D012367:RNA, Viral