title: The Relationship between Betatrophin Levels in Blood and T2DM: A Systematic Review and Meta-Analysis.
abstract: BACKGROUND
  In order to clarify previous ambiguous research conclusions, a meta-analysis was made to investigate the relationship between betatrophin levels in blood and type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  We have searched all the English and Chinese references regarding the relationship between betatrophin and diabetes in database both manually and online. Strict criteria have been established to include and exclude articles, with Mean and Standard Deviation as statistics to evaluate strength of association. We have chosen either fixed- or random effect model according to heterogeneity inspection results and used Begg's test and Egger's test to analyze publication bias.
  
  
  RESULTS
  A total of 11 studies were included in this meta-analysis. Meta-analysis indicated a significant association between betatrophin and T2DM (Mean: 329.46; 95% confidence interval: 182.51 to 476.42, P < 0.0001). However, in the subgroup analysis, there was no significant statistic between betatrophin concentration and T2DM within Caucasian population (Mean: 98.40; 95% confidence interval: -1585.08 to 1781.88, P = 0.91).
  
  
  CONCLUSIONS
  Such relationship may suggest preference for association between betatrophin and T2DM in different population.
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Song
authors.initials: S
authors.lastname: Yue
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Jingyang
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Jiahua
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110001, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
mesh_terms: D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000378:metabolism; D006801:Humans; D036361:Peptide Hormones / Q000097:blood*; D044465:White People
chemical_list: C576683:ANGPTL8 protein, human; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D036361:Peptide Hormones