title: Implementation of a High-Resolution Single-Nucleotide Polymorphism Array in Analyzing the Products of Conception.
abstract: OBJECTIVE
  To demonstrate the value of a whole-genome high-resolution single-nucleotide polymorphism (SNP) array for the elucidation of genetic causes underlying pregnancy loss.
  
  
  METHODS
  The SNP array combined with SNPs and oligonucleotide probes was used to examine 60 samples of products of conception, including chorionic villi, fetal parts, and fetal blood.
  
  
  RESULTS
  The SNP array yielded a 38.3% (23/60) abnormality rate. In addition to the most common aneuploidy, it detected 16.7% additional aberrations involving copy number variation, triploidy, loss of heterozygosity or low-level mosaicism.
  
  
  CONCLUSIONS
  This whole-genome high-resolution SNP array not only provides copy number information but also identifies the heterozygosity status, which facilitates the discovery of the novel genetic alterations associated with pregnancy failure and improves the management of subsequent pregnancies.
authors.affiliation: 1 Graduate School, Southern Medical University , Guangzhou, P.R. China .|2 Key Laboratory for Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Third Affiliated Hospital of Guangzhou Medical University , Guangzhou, P.R. China .
authors.forename: HuiMin
authors.initials: H
authors.lastname: Zhang
authors.affiliation: 2 Key Laboratory for Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Third Affiliated Hospital of Guangzhou Medical University , Guangzhou, P.R. China .
authors.forename: WeiQiang
authors.initials: W
authors.lastname: Liu
authors.affiliation: 2 Key Laboratory for Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Third Affiliated Hospital of Guangzhou Medical University , Guangzhou, P.R. China .
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: 2 Key Laboratory for Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Third Affiliated Hospital of Guangzhou Medical University , Guangzhou, P.R. China .
authors.forename: ZhiHua
authors.initials: Z
authors.lastname: Li
authors.affiliation: 2 Key Laboratory for Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Third Affiliated Hospital of Guangzhou Medical University , Guangzhou, P.R. China .
authors.forename: XiaoFang
authors.initials: X
authors.lastname: Sun
authors.affiliation: 1 Graduate School, Southern Medical University , Guangzhou, P.R. China .|3 Shenzhen Maternity and Child Healthcare Hospital , Shenzhen, P.R. China .
authors.forename: ChenHong
authors.initials: C
authors.lastname: Wang
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics*; D000782:Aneuploidy; D002869:Chromosome Aberrations / Q000196:embryology*; D056915:DNA Copy Number Variations; D005260:Female; D005306:Fertilization / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy