title: Iridium Catalysts with f-Amphox Ligands: Asymmetric Hydrogenation of Simple Ketones.
abstract: A series of modular and rich electronic tridentate ferrocene aminophosphoxazoline ligands (f-amphox) have been successfully developed and used in iridium-catalytic asymmetric hydrogenation of simple ketones to afford corresponding enantiomerically enriched alcohols under mild conditions with superb activities and excellent enantioselectivities (up to 1 000 000 TON, almost all products up to >99% ee, full conversion). The resulting chiral alcohols and their derivatives are important intermediates in pharmaceuticals.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Weilong
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Chemistry and Chemical Biology & Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey , Piscataway, New Jersey 08854, United States.
authors.forename: Shaodong
authors.initials: S
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, Chongqing University , Chongqing 400030, P. R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Duan
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Tan
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Caiyou
authors.initials: C
authors.lastname: Chen
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Xie
authors.affiliation: School of Chemistry and Chemical Engineering, Chongqing University , Chongqing 400030, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lan
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, P. R. China.
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Dong
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, P. R. China.|Department of Chemistry and Chemical Biology & Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey , Piscataway, New Jersey 08854, United States.
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D000075163:Metallocenes / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013816:Thermodynamics
chemical_list: D000438:Alcohols; D005296:Ferrous Compounds; D007659:Ketones; D008024:Ligands; D000075163:Metallocenes; D010080:Oxazoles; D007495:Iridium; C004998:ferrocene