title: Residential Risk Factors for Atopic Dermatitis in 3- to 6-Year Old Children: A Cross-Sectional Study in Shanghai, China.
abstract: Atopic dermatitis (AD) is common among pre-school children in Shanghai. This study aimed to identify the risk factors for childhood AD from the perspectives of home environment, demographics and parents-grandparents' atopic disease.
  
  
  
  A cross-sectional study was conducted in Shanghai in April-June, 2010. Preschool children's parents or guardians were invited to participate a questionnaire survey in six districts (two urban and four suburban/rural) and 6624 children were finally recruited (51.3% boys). AD diagnosis was based on the U.K. Working Party's (UKWP) criteria. Adjusted odds ratios (AOR) with 95% confidence intervals (95% CI) were calculated by multiple logistic regression.
  
  
  
  A total of 8.5% of children ever had AD. Around 10.2% of the mothers had lived in newly renovated/decorated homes (NRDH) during the prenatal period (one year before or during pregnancy) and 9.5% got new home furniture (NHF) during the same period. AD was more common in children when mothers had lived in NRDH homes during the prenatal period (AOR = 1.41; 95% CI 1.03-1.93), the current home had indoor mold (2.00, 1.48-2.70), parents-grandparents' had atopic diseases (3.85, 3.05-4.87), the children had food allergy (3.40, 2.63-4.40) or children lived in urban area (1.52, 1.18-1.96). Associations between AD and NRDH, NHF and indoor molds were only significant in children without parents-grandparents' atopic diseases. There was an interaction effect between parents-grandparents' atopic diseases and NRDH (p < 0.05).
  
  
  
  Home renovation/ redecoration, new furniture and indoor mold, urban residency, heredity disposition and food allergy can be risk factors for childhood AD in Shanghai.
authors.affiliation: Department of Dermatology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China. xufengdoctor@126.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Dermatology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China. shuxianyan0225@126.com.
authors.forename: Shuxian
authors.initials: S
authors.lastname: Yan
authors.affiliation: Department of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350000, China. ale08172@126.com.
authors.forename: Qile
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: Department of Dermatology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China. feyfey252@hotmail.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Dermatology, Jiading District Traditional Chinese Medicine Hospital, Shanghai 201800, China. chaiweihan@163.com.
authors.forename: Weihan
authors.initials: W
authors.lastname: Chai
authors.affiliation: School of Public Health, Key Lab of Public Health Safety of the Ministry of Education &amp; Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China. mmwu@fudan.edu.cn.
authors.forename: Minmin
authors.initials: M
authors.lastname: Wu
authors.affiliation: School of Public Health, Key Lab of Public Health Safety of the Ministry of Education &amp; Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China. hdkan@shmu.edu.cn.
authors.forename: Haidong
authors.initials: H
authors.lastname: Kan
authors.affiliation: Department of Medical Science, Occupational and Environmental Medicine, Uppsala University, Uppsala 75185, Sweden. dan.norback@medsci.uu.se.
authors.forename: Dan
authors.initials: D
authors.lastname: Norback
authors.affiliation: Department of Dermatology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China. xujinhua2012@sina.com.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Xu
authors.affiliation: School of Public Health, Key Lab of Public Health Safety of the Ministry of Education &amp; Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China. zhzhao@fudan.edu.cn.
authors.forename: Zhuohui
authors.initials: Z
authors.lastname: Zhao
mesh_terms: D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003876:Dermatitis, Atopic / Q000453:epidemiology* / Q000209:etiology*; D004485:Eczema; D005260:Female; D005512:Food Hypersensitivity; D005658:Fungi; D006798:Housing; D006801:Humans; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D010290:Parents; D011247:Pregnancy; D015995:Prevalence; D012307:Risk Factors; D014505:Urban Population
keywords: dampness; dermatology; heredity; home environment; mold; redecoration; urban residency