title: Potassium homeostasis in chronic kidney disease.
abstract: Adaptive increases in renal and gastrointestinal excretion of K+ help to prevent hyperkalemia in patients with CKD as long as the GFR remains > 15-20 mL/min. Once the GFR falls below these values, the impact of factors known to adversely affect K+ homeostasis is significantly magnified. Impaired renal K+ excretion can be the result of conditions that severely limit distal Na+ delivery, decreased mineralocorticoid levels or activity, or a distal tubular defect (Table 2). In clinical practice, hyperkalemia is usually the result of a combination of factors superimposed on renal dysfunction.
authors.forename: Biff F
authors.initials: BF
authors.lastname: Palmer
mesh_terms: D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D006947:Hyperkalemia / Q000097:blood / Q000209:etiology* / Q000628:therapy*; D011188:Potassium / Q000097:blood*; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012307:Risk Factors
chemical_list: D011188:Potassium