title: Effect of sow vaccination against porcine circovirus type 2 (PCV2) on virological profiles in herds with or without PCV2 systemic disease.
abstract: We investigated porcine circovirus type 2 (PCV2) virological profiles in herds affected (PCVAD-AH, n = 5) or non-affected (PCVAD-NAH, n = 4) by PCV2-associated diseases (PCVAD), before and after 1 y of PCV2 gilt and sow vaccination. Fresh feces from the floor (5 pens/age/farm) and 5 blood samples (1/pen) were collected at 3, 9, 15, 21 wk. Individual feces and blood samples were collected from 5 gilts and 15 sows. Sampling was repeated 1 y after vaccination. Quantitative PCR on feces, PCV2 antibodies in blood serum and cell-mediated immunity were investigated. Before vaccination, pigs of PCVAD-AH had higher viral load in feces (9 and 15 wk), lower IgG and higher IgM (3 wk) and lower lymphocyte counts (9 and 15 wk) suggesting immunosuppression. Vaccination reduced viral load in growers, increased IgG (3 wk) suggesting improved maternal immunity, reduced IgM (3 wk), increased total antibody titers in sows and increased CD79a cells in the pigs.
authors.affiliation: Faculty of Veterinary Medicine, Ghent University, Belgium (Lopez-Rodriguez, Dewulf, Del-Pozo-Sacristán, Maes); Merial SAS, Lyon, France (Meyns, Andreoni, Chapat, Charreyre, Joisel); PX Biosolutions, South Melbourne, Australia (Goubier).
authors.forename: Alfonso
authors.initials: A
authors.lastname: Lopez-Rodriguez
authors.affiliation: Faculty of Veterinary Medicine, Ghent University, Belgium (Lopez-Rodriguez, Dewulf, Del-Pozo-Sacristán, Maes); Merial SAS, Lyon, France (Meyns, Andreoni, Chapat, Charreyre, Joisel); PX Biosolutions, South Melbourne, Australia (Goubier).
authors.forename: Jeroen
authors.initials: J
authors.lastname: Dewulf
authors.affiliation: Faculty of Veterinary Medicine, Ghent University, Belgium (Lopez-Rodriguez, Dewulf, Del-Pozo-Sacristán, Maes); Merial SAS, Lyon, France (Meyns, Andreoni, Chapat, Charreyre, Joisel); PX Biosolutions, South Melbourne, Australia (Goubier).
authors.forename: Tom
authors.initials: T
authors.lastname: Meyns
authors.affiliation: Faculty of Veterinary Medicine, Ghent University, Belgium (Lopez-Rodriguez, Dewulf, Del-Pozo-Sacristán, Maes); Merial SAS, Lyon, France (Meyns, Andreoni, Chapat, Charreyre, Joisel); PX Biosolutions, South Melbourne, Australia (Goubier).
authors.forename: Rubén
authors.initials: R
authors.lastname: Del-Pozo-Sacristán
authors.affiliation: Faculty of Veterinary Medicine, Ghent University, Belgium (Lopez-Rodriguez, Dewulf, Del-Pozo-Sacristán, Maes); Merial SAS, Lyon, France (Meyns, Andreoni, Chapat, Charreyre, Joisel); PX Biosolutions, South Melbourne, Australia (Goubier).
authors.forename: Christine
authors.initials: C
authors.lastname: Andreoni
authors.affiliation: Faculty of Veterinary Medicine, Ghent University, Belgium (Lopez-Rodriguez, Dewulf, Del-Pozo-Sacristán, Maes); Merial SAS, Lyon, France (Meyns, Andreoni, Chapat, Charreyre, Joisel); PX Biosolutions, South Melbourne, Australia (Goubier).
authors.forename: Anne
authors.initials: A
authors.lastname: Goubier
authors.affiliation: Faculty of Veterinary Medicine, Ghent University, Belgium (Lopez-Rodriguez, Dewulf, Del-Pozo-Sacristán, Maes); Merial SAS, Lyon, France (Meyns, Andreoni, Chapat, Charreyre, Joisel); PX Biosolutions, South Melbourne, Australia (Goubier).
authors.forename: Ludivine
authors.initials: L
authors.lastname: Chapat
authors.affiliation: Faculty of Veterinary Medicine, Ghent University, Belgium (Lopez-Rodriguez, Dewulf, Del-Pozo-Sacristán, Maes); Merial SAS, Lyon, France (Meyns, Andreoni, Chapat, Charreyre, Joisel); PX Biosolutions, South Melbourne, Australia (Goubier).
authors.forename: Catherine
authors.initials: C
authors.lastname: Charreyre
authors.affiliation: Faculty of Veterinary Medicine, Ghent University, Belgium (Lopez-Rodriguez, Dewulf, Del-Pozo-Sacristán, Maes); Merial SAS, Lyon, France (Meyns, Andreoni, Chapat, Charreyre, Joisel); PX Biosolutions, South Melbourne, Australia (Goubier).
authors.forename: François
authors.initials: F
authors.lastname: Joisel
authors.affiliation: Faculty of Veterinary Medicine, Ghent University, Belgium (Lopez-Rodriguez, Dewulf, Del-Pozo-Sacristán, Maes); Merial SAS, Lyon, France (Meyns, Andreoni, Chapat, Charreyre, Joisel); PX Biosolutions, South Melbourne, Australia (Goubier).
authors.forename: Dominiek
authors.initials: D
authors.lastname: Maes
mesh_terms: D000818:Animals; D051925:CD79 Antigens / Q000097:blood; D018173:Circoviridae Infections / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D017925:Circovirus; D005243:Feces / Q000821:virology; D005260:Female; D007111:Immunity, Cellular; D060888:Real-Time Polymerase Chain Reaction; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control / Q000821:virology*; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D051925:CD79 Antigens; D014765:Viral Vaccines