title: Effects of subchronic extremely low-frequency electromagnetic field exposure on biochemical parameters in rats.
abstract: The objective of the present study was to systematically determine the effects of 50 Hertz (Hz) magnetic fields (MFs) on biochemical parameters in rats. Sixty-four adult (5 weeks old, 140-165 g) male Sprague-Dawley rats were randomly divided into four groups: sham, 20 µTesla (µT), 100 µT, and 500 µT 50 Hz MF ( n = 16 in each group). The rats in the MF groups were exposed for 2 h daily for up to 4 weeks. Under these experimental conditions, body weight, organ coefficients, biochemical parameters (blood lipids, myocardial enzymes, liver function, and renal function) were measured. We found that 50 Hz MFs had no significant effects on growth or on the majority of blood biochemical parameters, with the exception of creatinine and cholesterol. However, the changes in creatinine and cholesterol were relatively small and unlikely to be clinically relevant.
authors.affiliation: 1 Institute of Tropical Medicine, Third Military Medical University, Shapingba District, Chongqing, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Luo
authors.affiliation: 2 Department of Occupational Health, Third Military Medical University, Shapingba District, Chongqing, China.
authors.forename: Lingjuan
authors.initials: L
authors.lastname: Ma
authors.affiliation: 2 Department of Occupational Health, Third Military Medical University, Shapingba District, Chongqing, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Gao
authors.affiliation: 2 Department of Occupational Health, Third Military Medical University, Shapingba District, Chongqing, China.
authors.forename: Yanwen
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D004307:Dose-Response Relationship, Radiation; D004574:Electromagnetic Fields / Q000009:adverse effects*; D060733:Electromagnetic Radiation; D006321:Heart / Q000528:radiation effects; D048550:Hepatic Insufficiency / Q000097:blood / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D007668:Kidney / Q000502:physiology / Q000503:physiopathology / Q000528:radiation effects; D008099:Liver / Q000502:physiology / Q000503:physiopathology / Q000528:radiation effects; D008297:Male; D009206:Myocardium / Q000201:enzymology; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D051437:Renal Insufficiency / Q000097:blood / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D059550:Toxicity Tests, Subchronic; D015430:Weight Gain / Q000528:radiation effects
chemical_list: D015415:Biomarkers; D002784:Cholesterol; D003404:Creatinine
keywords: Animal model; biochemical parameters; biomarkers; magnetic field; serum