title: Relatedness-dependent rapid development of brain activity in anterior temporal cortex during pair-association retrieval.
abstract: Functional MRI studies have revealed that the brain activity in the anterior temporal cortex during memory retrieval increases over months after memory encoding. Behavioral evidence has demonstrated that long-term memory can sometimes be consolidated more rapidly in one or two days. In the present functional MRI study, we manipulated the relatedness between paired faces to be retrieved in a pair-association task. The brain activity in the anterior temporal cortex during retrieval of paired associates increased rapidly in one day, as shown in previous studies. We found that the speed of the brain activity development was dependent on the level of semantic relatedness of paired faces. The results suggest that the semantic relatedness enhances the speed of formation of memory representation in the anterior temporal cortex.
authors.affiliation: Department of Physiology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan; Department of Biosciences and Informatics, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama, Japan; Precision and Intelligence Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Japan; Department of Physiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan. Electronic address: jimura@bio.keio.ac.jp.
authors.forename: Koji
authors.initials: K
authors.lastname: Jimura
authors.affiliation: Department of Physiology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan; Department of Physiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirose
authors.affiliation: Department of Radiology, NTT Medical Center Tokyo, 5-9-22 Higashi Gotanda, Shinagawa-ku, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Wada
authors.affiliation: Department of Radiology, NTT Medical Center Tokyo, 5-9-22 Higashi Gotanda, Shinagawa-ku, Tokyo, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Yoshizawa
authors.affiliation: Department of Radiology, NTT Medical Center Tokyo, 5-9-22 Higashi Gotanda, Shinagawa-ku, Tokyo, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Imai
authors.affiliation: Department of Radiology, NTT Medical Center Tokyo, 5-9-22 Higashi Gotanda, Shinagawa-ku, Tokyo, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Akahane
authors.affiliation: Department of Radiology, NTT Medical Center Tokyo, 5-9-22 Higashi Gotanda, Shinagawa-ku, Tokyo, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Machida
authors.affiliation: Department of Radiology, NTT Medical Center Tokyo, 5-9-22 Higashi Gotanda, Shinagawa-ku, Tokyo, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Shirouzu
authors.affiliation: Precision and Intelligence Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Japan.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Koike
authors.affiliation: Department of Physiology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan; Department of Physiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan. Electronic address: skonishi@juntendo.ac.jp.
authors.forename: Seiki
authors.initials: S
authors.lastname: Konishi
mesh_terms: D000328:Adult; D001245:Association Learning / Q000502:physiology; D001931:Brain Mapping; D000066499:Facial Recognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D000069077:Memory Consolidation / Q000502:physiology*; D010775:Photic Stimulation; D021641:Recognition, Psychology / Q000502:physiology*; D012660:Semantics; D013702:Temporal Lobe / Q000502:physiology*; D055815:Young Adult
keywords: Human; Memory consolidation; fMRI