title: Association between rs9930506 polymorphism of the fat mass & obesity-associated (FTO) gene & onset of obesity in Polish adults.
abstract: OBJECTIVE
  The fat mass and obesity-associated (FTO) gene is known to be associated with obesity. However, no data are available on the relation between FTO rs9930506 polymorphism and obesity in Polish population. The aim of this study was to evaluate an association between rs9930506 variants of the FTO gene and obesity in Polish adults.
  
  
  METHODS
  The study group consisted of 442 adults, aged 33.9 ±12.7 yr, with mean BMI 27.2 ± 5.4 kg/m2. The following variables were determined for each subject: fasting blood glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides. Real-time PCR was used to detect the A/G alleles of the rs9939506 polymorphism in the FTO gene. An association between the rs9930506 polymorphism and obesity was determined using codominant, dominant, and recessive models. The odds ratio (OR) was calculated to determine the risk of obesity associated with this polymorphism.
  
  
  RESULTS
  It was observed that the presence of FTO rs9939506 G allele was associated with increased risk for obesity and this association was found significant in both recessive (OR = 1.72, P = 0.014) and co-dominant (OR = 1.36, P = 0.031) models of inheritance. The FTO rs9939506 GG homozygotes had a significantly higher BMI than those with other genotypes.
  
  
  CONCLUSIONS
  This study shows that FTO rs9939506 GG genotype is related to higher BMI and is associated with obesity in Polish adults.
authors.affiliation: Department of Pharmacogenomics, Division of Biochemistry & Clinical Chemistry, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wrzosek
authors.affiliation: Department of Pharmacogenomics, Division of Biochemistry & Clinical Chemistry, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Zakrzewska
authors.affiliation: National Food & Nutrition Institute, Warsaw, Poland.
authors.forename: Lech
authors.initials: L
authors.lastname: Ruczko
authors.affiliation: National Food & Nutrition Institute, Warsaw, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Jabłonowska-Lietz
authors.affiliation: Department of Pharmacogenomics, Division of Biochemistry & Clinical Chemistry, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Nowicka
mesh_terms: D000328:Adult; D000483:Alleles; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000235:genetics*; D015992:Body Mass Index; D008076:Cholesterol, HDL; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics* / Q000473:pathology; D011044:Poland; D020641:Polymorphism, Single Nucleotide
chemical_list: D008076:Cholesterol, HDL; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human