title: The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction.
abstract: The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (FGR). Here, we investigated pregnancies of ANP wild type (ANP(+/+)), heterozygous (ANP(+/-)) and knockout (ANP(-/-)) mice. Maternal blood pressure did not differ between genotypes (E12.5, E17.5), and fetal weight (E18.5) was unaffected. Placental weight was greater in ANP(-/-) versus ANP(+/+) mice. Therefore, in our hands, the ANP model does not express phenotypic features of PE with FGR.
authors.affiliation: Maternal and Fetal Health Research Centre, Institute of Human Development, The University of Manchester, Manchester Academic Health Science Centre, St. Mary's Hospital, Manchester, United Kingdom. Electronic address: sarah.finn-sell@manchester.ac.uk.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Finn-Sell
authors.affiliation: Maternal and Fetal Health Research Centre, Institute of Human Development, The University of Manchester, Manchester Academic Health Science Centre, St. Mary's Hospital, Manchester, United Kingdom.
authors.forename: Lewis J
authors.initials: LJ
authors.lastname: Renshall
authors.affiliation: Maternal and Fetal Health Research Centre, Institute of Human Development, The University of Manchester, Manchester Academic Health Science Centre, St. Mary's Hospital, Manchester, United Kingdom.
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Cowley
authors.affiliation: Maternal and Fetal Health Research Centre, Institute of Human Development, The University of Manchester, Manchester Academic Health Science Centre, St. Mary's Hospital, Manchester, United Kingdom.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Dilworth
authors.affiliation: Maternal and Fetal Health Research Centre, Institute of Human Development, The University of Manchester, Manchester Academic Health Science Centre, St. Mary's Hospital, Manchester, United Kingdom.
authors.forename: Mark
authors.initials: M
authors.lastname: Wareing
authors.affiliation: Maternal and Fetal Health Research Centre, Institute of Human Development, The University of Manchester, Manchester Academic Health Science Centre, St. Mary's Hospital, Manchester, United Kingdom.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Greenwood
authors.affiliation: Maternal and Fetal Health Research Centre, Institute of Human Development, The University of Manchester, Manchester Academic Health Science Centre, St. Mary's Hospital, Manchester, United Kingdom.
authors.forename: Colin P
authors.initials: CP
authors.lastname: Sibley
authors.affiliation: Maternal and Fetal Health Research Centre, Institute of Human Development, The University of Manchester, Manchester Academic Health Science Centre, St. Mary's Hospital, Manchester, United Kingdom.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Cottrell
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics* / Q000378:metabolism; D001794:Blood Pressure / Q000235:genetics*; D004195:Disease Models, Animal; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D010920:Placenta / Q000378:metabolism / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy
chemical_list: D009320:Atrial Natriuretic Factor
keywords: Atrial natriuretic peptide; Fetal growth restriction; Mouse; Pre-eclampsia