title: Interleukin-33, friend and foe in type-2 immune responses.
abstract: IL-33 is the most recent addition to the IL-1 cytokine family, identified in 2005 as the ligand of T1/ST2 and inducer of type-2 immune responses. IL-33 has been implicated in a wide range of disease settings, in anti-inflammatory responses and homeostasis, and thus signalling must be strictly regulated. Altered gene expression, post-translational modification, decoy receptor, and receptor signalling are all modulatory mechanisms used to control the IL-33 pathway. Understanding both the genetic and post-translational factors influencing IL-33 activity will be critical for provision of safe effective treatment of type-2 disorders.
authors.affiliation: MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, NIHR Biomedical Research Centre, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
authors.forename: Clare
authors.initials: C
authors.lastname: Hardman
authors.affiliation: MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, NIHR Biomedical Research Centre, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK. Electronic address: graham.ogg@ndm.ox.ac.uk.
authors.forename: Graham
authors.initials: G
authors.lastname: Ogg
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D007111:Immunity, Cellular; D000072179:Interleukin-1 Receptor-Like 1 Protein / Q000235:genetics / Q000378:metabolism*; D000067596:Interleukin-33 / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D018418:Th2 Cells / Q000276:immunology*; D014945:Wound Healing
chemical_list: D000893:Anti-Inflammatory Agents; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33