title: Prenatal ultrasound factors and genetic disorders in pregnancies complicated by polyhydramnios.
abstract: OBJECTIVE
  The objective of the study is to examine the incidence of chromosomal or genetic abnormalities in pregnancies complicated by polyhydramnios and to assess the value of prenatal ultrasound findings in the prediction of cases associated with such disorders.
  
  
  METHODS
  We searched the prenatal records of all patients delivered in our hospital with a diagnosis of polyhydramnios during pregnancy. For each case, maternal characteristics, ultrasound findings, and genetic testing results were recorded. A postnatal follow-up program of at least 6 months, including a clinical assessment by a clinical geneticist, was carried out in all cases.
  
  
  RESULTS
  On a total of 195 cases, genetic testing and clinical examination identified a chromosomal or genetic disease in 26 (13.3%) cases. Multivariate analysis demonstrated that significant predictors of a genetic disorder were a deepest vertical pocket of amniotic fluid of ≥13.0 cm (OR 4.306, 95%CI: 1.535-12.079) and reduced fetal movements (OR 25.084, 95%CI: 4.577-137.461), but not the presence of a structural defect.
  
  
  CONCLUSIONS
  A postnatal clinical follow-up program can reveal chromosomal or genetic disorders in about 13% of neonates with a prenatal diagnosis of polyhydramnios. The severity of polyhydramnios and the reduction of fetal movements are independently associated with the presence of such diseases. © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Department of Obstetrics and Gynecology 'L. Mangiagalli', Fondazione IRCCS 'Ca' Granda' - Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Boito
authors.affiliation: Department of Obstetrics and Gynecology 'L. Mangiagalli', Fondazione IRCCS 'Ca' Granda' - Ospedale Maggiore Policlinico, Milan, Italy.|Università degli Studi di Milano, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Crovetto
authors.affiliation: Department of Obstetrics and Gynecology 'L. Mangiagalli', Fondazione IRCCS 'Ca' Granda' - Ospedale Maggiore Policlinico, Milan, Italy.|Università degli Studi di Milano, Milan, Italy.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Ischia
authors.affiliation: Università degli Studi di Milano, Milan, Italy.|Department of Neonatology, Fondazione IRCCS 'Ca' Granda' - Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Beatrice Letizia
authors.initials: BL
authors.lastname: Crippa
authors.affiliation: Department of Obstetrics and Gynecology 'L. Mangiagalli', Fondazione IRCCS 'Ca' Granda' - Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Fabietti
authors.affiliation: Department of Clinical Genetics, Fondazione IRCCS 'Ca' Granda' - Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Maria Francesca
authors.initials: MF
authors.lastname: Bedeschi
authors.affiliation: Department of Clinical Genetics, Fondazione IRCCS 'Ca' Granda' - Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Faustina
authors.initials: F
authors.lastname: Lalatta
authors.affiliation: Department of Neonatology, Fondazione IRCCS 'Ca' Granda' - Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Colombo
authors.affiliation: Università degli Studi di Milano, Milan, Italy.|Department of Neonatology, Fondazione IRCCS 'Ca' Granda' - Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Mosca
authors.affiliation: Department of Obstetrics and Gynecology 'L. Mangiagalli', Fondazione IRCCS 'Ca' Granda' - Ospedale Maggiore Policlinico, Milan, Italy.|Università degli Studi di Milano, Milan, Italy.
authors.forename: Luigi
authors.identifier: http://orcid.org/0000-0001-6297-7165
authors.initials: L
authors.lastname: Fedele
authors.affiliation: Department of Obstetrics and Gynecology 'L. Mangiagalli', Fondazione IRCCS 'Ca' Granda' - Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Persico
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000000981:diagnostic imaging*; D025063:Chromosome Disorders / Q000453:epidemiology*; D000013:Congenital Abnormalities / Q000000981:diagnostic imaging / Q000453:epidemiology*; D005260:Female; D005324:Fetal Movement; D005500:Follow-Up Studies; D030342:Genetic Diseases, Inborn / Q000453:epidemiology*; D005820:Genetic Testing; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D015999:Multivariate Analysis; D006831:Polyhydramnios / Q000000981:diagnostic imaging / Q000453:epidemiology*; D011247:Pregnancy; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal