title: Dynamic light scattering (DLS)-based immunoassay for ultra-sensitive detection of tumor marker protein.
abstract: A novel dynamic light scattering (DLS)-based immunoassay that utilizes manganese dioxide nanosheet-modified gold nanoparticles (MnO2-GNPs) as an activatable nanoprobe has been developed to detect tumor markers down to femtomolar levels.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, China. Genxili@nju.edu.cn.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, China. Genxili@nju.edu.cn and State Key Laboratory of Reproductive Medicine, Department of Reproductive Health, Nanjing Maternity and Child Health Care Hospital affiliated with Nanjing Medical University, Nanjing, Jiangsu, China.
authors.forename: Jiehua
authors.initials: J
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, China. Genxili@nju.edu.cn.
authors.forename: Qiongxuan
authors.initials: Q
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, China. Genxili@nju.edu.cn.
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Tao
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, China. Genxili@nju.edu.cn and Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai 200444, China.
authors.forename: Genxi
authors.initials: G
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D000067493:Dynamic Light Scattering; D005456:Fluorescent Dyes / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D017895:Manganese Compounds / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D057054:Molecular Imaging; D009363:Neoplasm Proteins / Q000032:analysis*; D010087:Oxides / Q000737:chemistry*
chemical_list: D014408:Biomarkers, Tumor; D005456:Fluorescent Dyes; D017895:Manganese Compounds; D009363:Neoplasm Proteins; D010087:Oxides; D006046:Gold; C016552:manganese dioxide