title: Well-Differentiated Grade 2, Type 3 Gastrointestinal Neuroendocrine Tumour with Bilateral Metastatic Ovarian Involvement: Report of an Unusual Case.
abstract: Treatment of metastatic gastric neuroendocrine tumours (NETs) is challenging. In oligometastatic cases, surgical resection is recommended whenever possible. Somatostatin analogues have been used to decrease gastrin levels, and available evidence suggests that these drugs can also reduce recurrences. Here we present a highly unusual case involving a patient with a well-differentiated grade 2, type 3 gastric NET with exclusive metastatic bilateral ovarian involvement. To our knowledge, this is the first such case reported in the literature, as the cause of ovarian involvement is usually due to local invasion rather than metastasis. We believe this case is of interest not only due to the unusual presentation, but also because it makes us consider adjuvant treatment with somatostatin analogues in patients with low-grade tumours and a positive postoperative octreoscan.
authors.affiliation: Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Ray
authors.initials: R
authors.lastname: Manneh
authors.affiliation: Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Castellano
authors.affiliation: Department of General Surgery, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Caso
authors.affiliation: Department of General Surgery, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Loinaz
authors.affiliation: Department of Gynecology and Obstetrics, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Jiménez
authors.affiliation: Department of Nuclear Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Juana
authors.initials: J
authors.lastname: Estenoz
authors.affiliation: Department of Endocrinology, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Calatayud
authors.affiliation: Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Sepúlveda
authors.affiliation: Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Rocio
authors.initials: R
authors.lastname: García-Carbonero
keywords: Gastric cancer; Neoplasm recurrence, local; Neuroendocrine tumors; Somatostatin; Stomach neoplasms