title: Synthesis, anti-proliferative and genotoxicity studies of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2H-indol-2-ones and 6-chloro-5-(2-chloroethyl)-3-(alkyl/ary-2-ylidene)indolin-2-ones.
abstract: A series of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2H-indol-2-ones (3a-h) and 6-chloro-5-(2-chloroethyl)-3-(alkyl/aryl-2-ylidene)indolin-2-ones (5i-x) were synthesized. Compounds 3a-e, 5i-l and 5q-r were selected by NIH, USA for in vitro anti-proliferative screening. Based on the impressive growth inhibitory (GI %) effect by the compounds 3a-b and 3e which showed growth inhibition in the range 1.22-76.30%, 2.85-76.03% and 10.98-82.05% respectively at 10(-5) concentration, these compounds were further analyzed for anti-proliferative activity at 5 dose concentration and genotoxicity.
authors.affiliation: R. L. Fine Chemicals Ltd. Yelahanka, Bangalore 560064, India.
authors.forename: Gangadhar Y
authors.initials: GY
authors.lastname: Meti
authors.affiliation: Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, India.
authors.forename: Atulkumar A
authors.initials: AA
authors.lastname: Kamble
authors.affiliation: Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, India. Electronic address: kamchem9@gmail.com.
authors.forename: Ravindra R
authors.initials: RR
authors.lastname: Kamble
authors.affiliation: Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, India.
authors.forename: Shilpa M
authors.initials: SM
authors.lastname: Somagond
authors.affiliation: Department of Physics, Yuvaraja's College, Mysore 570005, India.
authors.forename: H C
authors.initials: HC
authors.lastname: Devarajegowda
authors.affiliation: Division of Clinical Embryology, Kasturba Medical College, Manipal University, Manipal 576104, Karnataka, India.
authors.forename: Sandhya
authors.initials: S
authors.lastname: Kumari
authors.affiliation: Division of Clinical Embryology, Kasturba Medical College, Manipal University, Manipal 576104, Karnataka, India.
authors.forename: Guruprasad
authors.initials: G
authors.lastname: Kalthur
authors.affiliation: Division of Clinical Embryology, Kasturba Medical College, Manipal University, Manipal 576104, Karnataka, India.
authors.forename: Satish K
authors.initials: SK
authors.lastname: Adiga
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology; D009153:Mutagens / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D009153:Mutagens; C456900:indolin-2-one
keywords: 2H-Indol-2-ones; Anti-proliferative activity; Cell line; Genotoxicity