title: Sleep and Cognitive Abnormalities in Acute Minor Thalamic Infarction.
abstract: In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction (AMTI), we enrolled 27 patients with AMTI and 12 matched healthy individuals. Questionnaires about sleep and cognition as well as polysomnography (PSG) were performed on days 14 and 90 post-stroke. Compared to healthy controls, in patients with AMTI, hyposomnia was more prevalent; sleep architecture was disrupted as indicated by decreased sleep efficiency, increased sleep latency, and decreased non-rapid eye movement sleep stages 2 and 3; more sleep-related breathing disorders occurred; and cognitive functions were worse, especially memory. While sleep apnea and long-delay memory recovered to a large extent in the patients, other sleep and cognitive function deficit often persisted. Patients with AMTI are at an increased risk for hyposomnia, sleep structure disturbance, sleep apnea, and memory deficits. Although these abnormalities improved over time, the slow and incomplete improvement suggest that early management should be considered in these patients.
authors.affiliation: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Linyang
authors.initials: L
authors.lastname: Cui
authors.affiliation: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Tian
authors.affiliation: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Du
authors.affiliation: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Qiu
authors.affiliation: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China.|Department of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, 85013, USA.
authors.forename: Fu-Dong
authors.initials: FD
authors.lastname: Shi
authors.affiliation: Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China. xuerong1403@126.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Xue
mesh_terms: D000328:Adult; D000368:Aged; D020520:Brain Infarction / Q000150:complications* / Q000209:etiology / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D017286:Polysomnography; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000209:etiology*; D020521:Stroke / Q000150:complications; D013788:Thalamus / Q000473:pathology*; D013997:Time Factors
keywords: Acute minor thalamic infarction; Cognition; Polysomnography