title: [The progress in application of parathyroid hormone in craniomaxillofacial bone regeneration study].
abstract: Parathyroid hormone(PTH)is synthesized and secreted by chief cell of Gley's glands which possesses dual functions of catabolism and anabolism. It regulates the proliferation and differentiation of multiple cell lines including osteoblast, osteoclast and skeletal lining cells. Furthermore, PTH activates various signaling pathways which control calcium, phosphorous' metabolism and bone conversion, accelerating the bone regeneration and reconstruction. However, the study of PTH in craniomaxillofacial bone regeneration is relatively less and whether the role of parathyroid glands and the mechanism of ossification are consistent with the long bone or not needs further investigation. This review focuses on the progress of PTH in craniomaxillofacial bone regeneration in recent years.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Chen
authors.affiliation: Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Tang
mesh_terms: D001861:Bone Regeneration / Q000502:physiology*; D001842:Bone and Bones / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D002454:Cell Differentiation; D006801:Humans; D008437:Maxilla / Q000502:physiology; D010006:Osteoblasts / Q000166:cytology; D010010:Osteoclasts / Q000166:cytology; D010012:Osteogenesis / Q000502:physiology; D010280:Parathyroid Glands / Q000502:physiology; D010281:Parathyroid Hormone / Q000502:physiology*; D010758:Phosphorus / Q000378:metabolism; D015398:Signal Transduction; D012886:Skull / Q000502:physiology
chemical_list: D010281:Parathyroid Hormone; D010758:Phosphorus; D002118:Calcium