title: One-Pot Synthesis of α-Amino Acids through Carboxylation of Ammonium Ylides with CO2 Followed by Alkyl Migration.
abstract: A simple, yet powerful protocol for α-amino acid synthesis using carbon dioxide (CO2) was developed. α-Amino silanes could undergo four successive reactions (formation of ammonium salt, carboxylation, esterification, and 2,3- or 1,2-Stevens rearrangement) in the presence of allylic or benzylic halides under a CO2 atmosphere (1 atm). It is noteworthy that carboxylation at the position adjacent to a nitrogen atom proceeded via an ammonium ylide intermediate under mild conditions.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Mita
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.
authors.forename: Masumi
authors.initials: M
authors.lastname: Sugawara
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sato