title: Adipokines and soluble cell adhesion molecules in insulin resistant and non-insulin resistant women with polycystic ovary syndrome.
abstract: BACKGROUND
  Insulin resistance (IR) is closely associated with increased atherogenic risk.
  
  
  OBJECTIVE
  To investigate leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) levels and their relationship with each other and metabolic parameters in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  The study included 76 PCOS women divided into insulin resistant and non-insulin resistant. Anthropometric parameters, glucose and lipid parameters, leptin, adiponectin, sICAM-1 and sVCAM-1 were determined. Homeostasis model of IR index(HOMA-IR), atherogenic index of plasma(AIP) and leptin/adiponectin ratio were calculated. HOMA-IR > 2.5 and/or fasting plasma glucose/immunoreactive insulin ratio < 0.333 were used as markers for IR.
  
  
  RESULTS
  Non-insulin resistant PCOS had significantly higher adiponectin and sVCAM-1 levels. AIP was significantly higher in insulin resistant PCOS. Adiponectin showed a positive correlation with sVCAM-1 and sICAM-1.
  
  
  CONCLUSIONS
  Insulin resistant PCOS women were at higher atherogenic risk compared to non-insulin resistant group. sVCAM-1 data confirms the necessity of further investigations for clarifying its role in IR.
authors.affiliation: a Clinic of Endocrinology and Metabolic Diseases, "Sv. Georgy" University Hospital, Medical University , Plovdiv , Bulgaria.
authors.forename: Daniela Iv
authors.initials: DI
authors.lastname: Koleva
authors.affiliation: a Clinic of Endocrinology and Metabolic Diseases, "Sv. Georgy" University Hospital, Medical University , Plovdiv , Bulgaria.
authors.forename: Maria M
authors.initials: MM
authors.lastname: Orbetzova
authors.affiliation: b Department of Physiology , Medical University , Plovdiv , Bulgaria , and.
authors.forename: Julia G
authors.initials: JG
authors.lastname: Nikolova
authors.affiliation: c Department of Cardiology , "Sv. Karidad" University Hospital, Medical University , Plovdiv , Bulgaria.
authors.forename: Stefan B
authors.initials: SB
authors.lastname: Tyutyundzhiev
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1
keywords: Adiponectin; atherosclerosis; leptin; sICAM-1; sVCAM-1