title: Comprehensive review on cardio-oncology: Role of multimodality imaging.
abstract: Cancer and cardiovascular disease are the two leading causes of mortality worldwide. Evolving oncologic therapy, including the use of newer targeted agents, has led to an improvement in survival from childhood- and adult-onset cancers. Consequently, there has been a growing realization of cardiotoxic complications related to cancer therapy, with some complications manifesting over months to decades after completion of cancer treatment. This paper reviews cancer therapeutics-related cardiovascular toxicity and its manifestations, multimodality imaging techniques for surveillance and detection of this complication, and the current state of knowledge in this emerging field.
authors.affiliation: Birmingham Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors.forename: Carol
authors.initials: C
authors.lastname: Chen-Scarabelli
authors.affiliation: Division of Cardiovascular Disease, University of Alabama at Birmingham, 1530 3rd Avenue, South Tinsley Harrison Tower, Birmingham, Alabama, 35294-0006, USA.
authors.forename: Chad
authors.initials: C
authors.lastname: McRee
authors.affiliation: Birmingham Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.|Division of Cardiovascular Disease, University of Alabama at Birmingham, 1530 3rd Avenue, South Tinsley Harrison Tower, Birmingham, Alabama, 35294-0006, USA.
authors.forename: Massoud A
authors.initials: MA
authors.lastname: Leesar
authors.affiliation: Birmingham Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.|Division of Cardiovascular Disease, University of Alabama at Birmingham, 1530 3rd Avenue, South Tinsley Harrison Tower, Birmingham, Alabama, 35294-0006, USA.
authors.forename: Fadi G
authors.initials: FG
authors.lastname: Hage
authors.affiliation: Birmingham Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, USA. tscarabelli@uabmc.edu.|Division of Cardiovascular Disease, University of Alabama at Birmingham, 1530 3rd Avenue, South Tinsley Harrison Tower, Birmingham, Alabama, 35294-0006, USA. tscarabelli@uabmc.edu.
authors.forename: Tiziano M
authors.initials: TM
authors.lastname: Scarabelli
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D002309:Cardiology / Q000379:methods; D019317:Evidence-Based Medicine; D006331:Heart Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D006801:Humans; D008495:Medical Oncology / Q000379:methods; D064847:Multimodal Imaging / Q000379:methods*; D009369:Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging*
chemical_list: D000970:Antineoplastic Agents
keywords: Cancer; cardiotoxicity; chemotherapy; imaging; radiation