title: Effect of Continuous Positive Airway Pressure on Blood Pressure Variability in Patients With Obstructive Sleep Apnea.
abstract: Obstructive sleep apnea (OSA) is a common risk factor for cardiovascular disease. Continuous positive airway pressure (CPAP) improves OSA symptoms and blood pressure (BP) control. The effect of CPAP on BP variability (BPV) in patients with and without hypertension treated with autotitrating CPAP (APAP) for 2 weeks was studied. A total of 78 participants (76.9% men, 49% hypertensive, mean body mass index 36.2 [6.9] kg/m2, age 49.0 [12.9] years) underwent 2 weeks of APAP therapy. Office BP, BPV (standard deviation of three BP measurements), and pulse rate were measured before and after treatment. Systolic BPV (5.3±4.9 vs 4.2±3.4 mm Hg, P=.047) and pulse rate (78.0±14.5 vs 75.5±15.8 beats per minute, P=.032) decreased after treatment, particularly in hypertensive participants. Mask leak was independently associated with reduced changes in systolic BPV (r=-0.237, P=.048). Short-term APAP treatment reduced BPV and pulse rate, particularly in hypertensive patients with OSA.
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, Lane Fox Respiratory Unit/Sleep Disorders Centre, London, UK. martino.pengo@gstt.nhs.uk.|Department of Medicine (DIMED), University of Padua, Padova, Italy. martino.pengo@gstt.nhs.uk.|King's College London, Faculty of Life Sciences and Medicine, London, UK. martino.pengo@gstt.nhs.uk.
authors.forename: Martino F
authors.initials: MF
authors.lastname: Pengo
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, Lane Fox Respiratory Unit/Sleep Disorders Centre, London, UK.
authors.forename: Culadeeban
authors.initials: C
authors.lastname: Ratneswaran
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, Lane Fox Respiratory Unit/Sleep Disorders Centre, London, UK.
authors.forename: Marc
authors.initials: M
authors.lastname: Berry
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, Lane Fox Respiratory Unit/Sleep Disorders Centre, London, UK.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Kent
authors.affiliation: Department of Pneumology, University Hospital of Zurich and Center for Interdisciplinary Sleep Research, University of Zurich, Zurich, Switzerland.
authors.forename: Malcolm
authors.initials: M
authors.lastname: Kohler
authors.affiliation: Department of Medicine (DIMED), University of Padua, Padova, Italy.
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Rossi
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, Lane Fox Respiratory Unit/Sleep Disorders Centre, London, UK.|King's College London, Faculty of Life Sciences and Medicine, London, UK.
authors.forename: Joerg
authors.initials: J
authors.lastname: Steier
mesh_terms: D000328:Adult; D001794:Blood Pressure; D001795:Blood Pressure Determination; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011446:Prospective Studies; D020181:Sleep Apnea, Obstructive / Q000628:therapy*