title: Multi-Drug-Loaded Microcapsules with Controlled Release for Management of Parkinson's Disease.
abstract: Parkinson's disease (PD) is a progressive disease of the nervous system, and is currently managed through commercial tablets that do not sufficiently enable controlled, sustained release capabilities. It is hypothesized that a drug delivery system that provides controlled and sustained release of PD drugs would afford better management of PD. Hollow microcapsules composed of poly-l-lactide (PLLA) and poly (caprolactone) (PCL) are prepared through a modified double-emulsion technique. They are loaded with three PD drugs, i.e., levodopa (LD), carbidopa (CD), and entacapone (ENT), at a ratio of 4:1:8, similar to commercial PD tablets. LD and CD are localized in both the hollow cavity and PLLA/PCL shell, while ENT is localized in the PLLA/PCL shell. Release kinetics of hydrophobic ENT is observed to be relatively slow as compared to the other hydrophilic drugs. It is further hypothesized that encapsulating ENT into PCL as a surface coating onto these microcapsules can aid in accelerating its release. Now, these spray-coated hollow microcapsules exhibit similar release kinetics, according to Higuchi's rate, for all three drugs. The results suggest that multiple drug encapsulation of LD, CD, and ENT in gastric floating microcapsules could be further developed for in vivo evaluation for the management of PD.
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798.
authors.forename: Jong-Suep
authors.initials: JS
authors.lastname: Baek
authors.affiliation: School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551.
authors.forename: Chee Chong
authors.initials: CC
authors.lastname: Choo
authors.affiliation: School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371.
authors.forename: Cheng
authors.initials: C
authors.lastname: Qian
authors.affiliation: School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551.
authors.forename: Nguan Soon
authors.initials: NS
authors.lastname: Tan
authors.affiliation: School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371.
authors.forename: Zexiang
authors.initials: Z
authors.lastname: Shen
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798.|Singapore Centre on Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551.
authors.forename: Say Chye Joachim
authors.initials: SC
authors.lastname: Loo
mesh_terms: D000818:Animals; D002208:Caproates / Q000737:chemistry; D002214:Capsules / Q000737:chemistry*; D002230:Carbidopa / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D002396:Catechols / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007783:Lactones / Q000737:chemistry; D007980:Levodopa / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D018613:Microscopy, Confocal; D009570:Nitriles / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D010300:Parkinson Disease / Q000188:drug therapy*; D011091:Polyesters / Q000737:chemistry
chemical_list: D002208:Caproates; D002214:Capsules; D002396:Catechols; D003692:Delayed-Action Preparations; D007783:Lactones; D009570:Nitriles; D011091:Polyesters; C033616:poly(lactide); D007980:Levodopa; C071192:entacapone; C121056:caprolactone; D002230:Carbidopa
keywords: Parkinson's disease; controlled release; drug delivery; spray-coating