title: Synthesis of γ,δ-Unsaturated α-Aminoaldehydes Using a Copper-Catalyzed Vinylation Reaction Followed by a Claisen Rearrangement.
abstract: A new method to synthesize γ,δ-unsaturated α-nitrogenated aldehydes in very good yields is described herein. This method involves a copper-coupling reaction between β-iodoenamide derivatives and allylic alcohols to generate β-allyloxyenamide derivatives. The latter, when heated, undergo a Claisen rearrangement and form γ,δ-unsaturated α-nitrogenated aldehydes.
authors.affiliation: Département de Chimie, Biochimie et Physique, Université du Québec à Trois-Rivières , Trois-Rivières, Québec G9A 5H7, Canada.
authors.forename: Simon
authors.initials: S
authors.lastname: Ricard
authors.affiliation: Département de Chimie, Biochimie et Physique, Université du Québec à Trois-Rivières , Trois-Rivières, Québec G9A 5H7, Canada.
authors.forename: Gabriel F
authors.initials: GF
authors.lastname: Sanapo
authors.affiliation: Département de Chimie, Biochimie et Physique, Université du Québec à Trois-Rivières , Trois-Rivières, Québec G9A 5H7, Canada.
authors.forename: Neel
authors.initials: N
authors.lastname: Rahem
authors.affiliation: Département de Chimie, Biochimie et Physique, Université du Québec à Trois-Rivières , Trois-Rivières, Québec G9A 5H7, Canada.
authors.forename: Benoit
authors.initials: B
authors.lastname: Daoust