title: Revealing stiffening and brittling of chronic myelogenous leukemia hematopoietic primary cells through their temporal response to shear stress.
abstract: Cancer cell transformation is often accompanied by a modification of their viscoelastic properties. When capturing the stress-to-strain response of primary chronic myelogenous leukemia (CML) cells, from two data sets of CD34+ hematopoietic cells isolated from healthy and leukemic bone marrows, we show that the mean shear relaxation modulus increases upon cancer transformation. This stiffening of the cells comes along with local rupture events, detected as reinforced sharp local maxima of this modulus, suggesting that these cancer cells respond to a local mechanical stress by a cascade of local brittle failure events.
authors.affiliation: CNRS UMR5672, Laboratoire de Physique, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69007 Lyon, France. Université de Lyon 1, 43 Boulevard du 11 Novembre 1918, 69100 Villeurbanne, France. CNRS UMR5286, INSERM U1052, Centre de Recherche en Cancérologie de Lyon, 28 rue Laennec, 69008 Lyon, France.
authors.forename: B
authors.initials: B
authors.lastname: Laperrousaz
authors.forename: L
authors.initials: L
authors.lastname: Berguiga
authors.forename: F E
authors.initials: FE
authors.lastname: Nicolini
authors.forename: C
authors.initials: C
authors.lastname: Martinez-Torres
authors.forename: A
authors.initials: A
authors.lastname: Arneodo
authors.forename: V Maguer
authors.initials: VM
authors.lastname: Satta
authors.forename: F
authors.initials: F
authors.lastname: Argoul
mesh_terms: D004548:Elasticity; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D033081:Shear Strength; D013314:Stress, Mechanical; D013997:Time Factors