title: Chemical constituents and biological research on plants in the genus Curcuma.
abstract: Curcuma, a valuable genus in the family Zingiberaceae, includes approximately 110 species. These plants are native to Southeast Asia and are extensively cultivated in India, China, Sri Lanka, Indonesia, Peru, Australia, and the West Indies. The plants have long been used in folk medicine to treat stomach ailments, stimulate digestion, and protect the digestive organs, including the intestines, stomach, and liver. In recent years, substantial progress has been achieved in investigations regarding the chemical and pharmacological properties, as well as in clinical trials of certain Curcuma species. This review comprehensively summarizes the current knowledge on the chemistry and briefly discusses the biological activities of Curcuma species. A total of 720 compounds, including 102 diphenylalkanoids, 19 phenylpropene derivatives, 529 terpenoids, 15 flavonoids, 7 steroids, 3 alkaloids, and 44 compounds of other types isolated or identified from 32 species, have been phytochemically investigated. The biological activities of plant extracts and pure compounds are classified into 15 groups in detail, with emphasis on anti-inflammatory and antitumor activities.
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao , China.
authors.forename: Wen
authors.initials: W
authors.lastname: Sun
authors.affiliation: b State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences , Beijing , China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao , China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Zhao
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao , China.
authors.forename: Chuanhong
authors.initials: C
authors.lastname: Wu
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao , China.
authors.forename: Shuhui
authors.initials: S
authors.lastname: Guo
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao , China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Gao
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao , China.
authors.forename: Hongxun
authors.initials: H
authors.lastname: Tao
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao , China.
authors.forename: Jinjian
authors.initials: J
authors.lastname: Lu
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao , China.
authors.forename: Yitao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao , China.
authors.forename: Xiuping
authors.initials: X
authors.lastname: Chen
mesh_terms: D000470:Alkaloids / Q000737:chemistry; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001315:Australia; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002681:China; D002986:Clinical Trials as Topic; D030024:Curcuma / Q000737:chemistry* / Q000145:classification; D004195:Disease Models, Animal; D005419:Flavonoids / Q000737:chemistry; D006801:Humans; D007194:India; D007214:Indonesia; D010568:Peru; D064209:Phytochemicals / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013188:Sri Lanka; D013256:Steroids / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D005419:Flavonoids; D064209:Phytochemicals; D010936:Plant Extracts; D013256:Steroids; D013729:Terpenes; C012596:turmeric extract
keywords: Antitumor; Bioactivities; Chemical Constituents; Genus Curcuma