title: Biocompatible Zr-based nanoscale MOFs coated with modified poly(ε-caprolactone) as anticancer drug carriers.
abstract: Nanoscale Zr-based metal organic frameworks (MOFs) UiO-66 and UiO-67 were studied as potential anticancer drug delivery vehicles. Two model drugs were used, hydrophobic paclitaxel and hydrophilic cisplatin, and were adsorbed onto/into the nano MOFs (NMOFs). The drug loaded MOFs were further encapsulated inside a modified poly(ε-caprolactone) with d-α-tocopheryl polyethylene glycol succinate polymeric matrix, in the form of microparticles, in order to prepare sustained release formulations and to reduce the drug toxicity. The drugs physical state and release rate was studied at 37°C using Simulated Body Fluid. It was found that the drug release depends on the interaction between the MOFs and the drugs while the controlled release rates can be attributed to the microencapsulated formulations. The in vitro antitumor activity was assessed using HSC-3 (human oral squamous carcinoma; head and neck) and U-87 MG (human glioblastoma grade IV; astrocytoma) cancer cells. Cytotoxicity studies for both cell lines showed that the polymer coated, drug loaded MOFs exhibited better anticancer activity compared to free paclitaxel and cisplatin solutions at different concentrations.
authors.affiliation: EMAT, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium. Electronic address: maria.filippousi@ua.ac.be.
authors.forename: Maria
authors.initials: M
authors.lastname: Filippousi
authors.affiliation: EMAT, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
authors.forename: Stuart
authors.initials: S
authors.lastname: Turner
authors.affiliation: Department of Inorganic and Physical Chemistry, Center for Ordered Materials, Organometallics and Catalysis (COMOC), Ghent University, Krijgslaan 281-S3, 9000 Ghent, Belgium.
authors.forename: Karen
authors.initials: K
authors.lastname: Leus
authors.affiliation: Laboratory of Polymer Chemistry and Technology, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Macedonia, Greece.
authors.forename: Panoraia I
authors.initials: PI
authors.lastname: Siafaka
authors.affiliation: Laboratory of Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Macedonia, Greece.
authors.forename: Eirini D
authors.initials: ED
authors.lastname: Tseligka
authors.affiliation: Center for Molecular Modeling, Universiteit Gent, Technologiepark 903, 9052 Zwijnaarde, Belgium.
authors.forename: Matthias
authors.initials: M
authors.lastname: Vandichel
authors.affiliation: Laboratory of Polymer Chemistry and Technology, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Macedonia, Greece.
authors.forename: Stavroula G
authors.initials: SG
authors.lastname: Nanaki
authors.affiliation: Laboratory of Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Macedonia, Greece; Department of Life and Health Sciences, University of Nicosia, 1700 Nicosia, Cyprus.
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Vizirianakis
authors.affiliation: Laboratory of Polymer Chemistry and Technology, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Macedonia, Greece.
authors.forename: Dimitrios N
authors.initials: DN
authors.lastname: Bikiaris
authors.affiliation: Department of Inorganic and Physical Chemistry, Center for Ordered Materials, Organometallics and Catalysis (COMOC), Ghent University, Krijgslaan 281-S3, 9000 Ghent, Belgium.
authors.forename: Pascal
authors.initials: P
authors.lastname: Van Der Voort
authors.affiliation: EMAT, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
authors.forename: Gustaaf
authors.initials: G
authors.lastname: Van Tendeloo
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry*; D002208:Caproates / Q000737:chemistry*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000008:administration & dosage / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007783:Lactones / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D014810:Vitamin E / Q000737:chemistry; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D002208:Caproates; D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007783:Lactones; D011108:Polymers; D014810:Vitamin E; D011092:Polyethylene Glycols; C121056:caprolactone; D015040:Zirconium; C014225:tocophersolan; D017239:Paclitaxel; D002945:Cisplatin
keywords: ADF-STEM; Drug delivery; Metal-organic frameworks/UiO-66; Polymer; SEM; UiO-67