title: Community Structure Reveals Biologically Functional Modules in MEF2C Transcriptional Regulatory Network.
abstract: Gene regulatory networks are useful to understand the activity behind the complex mechanisms in transcriptional regulation. A main goal in contemporary biology is using such networks to understand the systemic regulation of gene expression. In this work, we carried out a systematic study of a transcriptional regulatory network derived from a comprehensive selection of all potential transcription factor interactions downstream from MEF2C, a human transcription factor master regulator. By analyzing the connectivity structure of such network, we were able to find different biologically functional processes and specific biochemical pathways statistically enriched in communities of genes into the network, such processes are related to cell signaling, cell cycle and metabolism. In this way we further support the hypothesis that structural properties of biological networks encode an important part of their functional behavior in eukaryotic cells.
authors.affiliation: Computational Genomics Department, National Institute of Genomic MedicineMexico City, Mexico; Complexity in Systems Biology, Center for Complexity Sciences, Universidad Nacional Autónoma de MéxicoMexico City, Mexico.
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Alcalá-Corona
authors.affiliation: Computational Genomics Department, National Institute of Genomic Medicine Mexico City, Mexico.
authors.forename: Tadeo E
authors.initials: TE
authors.lastname: Velázquez-Caldelas
authors.affiliation: Computational Genomics Department, National Institute of Genomic MedicineMexico City, Mexico; Complexity in Systems Biology, Center for Complexity Sciences, Universidad Nacional Autónoma de MéxicoMexico City, Mexico.
authors.forename: Jesús
authors.initials: J
authors.lastname: Espinal-Enríquez
authors.affiliation: Computational Genomics Department, National Institute of Genomic MedicineMexico City, Mexico; Complexity in Systems Biology, Center for Complexity Sciences, Universidad Nacional Autónoma de MéxicoMexico City, Mexico.
authors.forename: Enrique
authors.initials: E
authors.lastname: Hernández-Lemus
keywords: FANTOM4; InfoMap; MEF2C; community structure; transcription factor; transcriptional regulatory networks