title: Prolonged Tp-e Interval and Tp-e/QT Ratio in Children with Mitral Valve Prolapse.
abstract: Although it is considered to be a benign condition, previous studies have shown that a subset of patients with mitral valve prolapse (MVP) may be at risk of ventricular arrhythmia and sudden cardiac death (SCD). Previous studies have suggested that the interval between the peak and the end of the T wave (Tp-e) can be used as a marker for the transmural dispersion of repolarization. Increased Tp-e interval and Tp-e/QT ratio are associated with ventricular arrhythmias and SCD. The aim of this study was to assess alterations in ventricular repolarization by using the Tp-e interval and Tp-e/QT ratio in children with MVP and to investigate their relationships with the degree of valvular regurgitation. This study prospectively investigated 110 children with MVP and 107 age- and sex-matched healthy control subjects. Tp-e interval, Tp-e/QT ratio, and QT and QTc dispersions were measured from a 12-lead electrocardiogram and compared between groups. QT and QTc dispersions, Tp-e interval, and Tp-e/QTc ratio were found to be significantly higher in patients with MVP. A positive correlation was found between Tp-e/QTc ratio and increase in the degree of mitral regurgitation (MR) (p < 0.05; r = 0.2). However, the degree of MR was not associated with QT, QTc, or Tp-e intervals; QT, QTc, or Tp-e dispersions; or Tp-e/QT ratio (all p values >0.05). Individuals with MVP may be more prone to ventricular arrhythmias due to prolonged QTd, QTcd, and Tp-e interval and increased Tp-e/QT and Tp-e/QTc ratios. Therefore, due to their longer life expectancy, children with MVP should be followed up on regarding life-threatening arrhythmias.
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, 1374 St. No:11, Alsancak, Izmir, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Demirol
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, 1374 St. No:11, Alsancak, Izmir, Turkey. karadenizcem@yahoo.com.
authors.forename: Cem
authors.initials: C
authors.lastname: Karadeniz
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, 1374 St. No:11, Alsancak, Izmir, Turkey.
authors.forename: Rahmi
authors.initials: R
authors.lastname: Ozdemir
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, 1374 St. No:11, Alsancak, Izmir, Turkey.
authors.forename: Şenay
authors.initials: Ş
authors.lastname: Çoban
authors.affiliation: Department of Pediatrics, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Nagehan
authors.initials: N
authors.lastname: Katipoğlu
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, 1374 St. No:11, Alsancak, Izmir, Turkey.
authors.forename: Yılmaz
authors.initials: Y
authors.lastname: Yozgat
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, 1374 St. No:11, Alsancak, Izmir, Turkey.
authors.forename: Timur
authors.initials: T
authors.lastname: Meşe
authors.affiliation: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, 1374 St. No:11, Alsancak, Izmir, Turkey.
authors.forename: Nurettin
authors.initials: N
authors.lastname: Unal
mesh_terms: D001145:Arrhythmias, Cardiac; D015415:Biomarkers; D002648:Child; D016757:Death, Sudden, Cardiac; D004562:Electrocardiography; D006801:Humans; D008945:Mitral Valve Prolapse
chemical_list: D015415:Biomarkers
keywords: Mitral valve prolapse; Tp–e interval; Tp–e/QT ratio; Tp–e/QTc ratio