title: Should A Tidal Volume of 6 mL/kg Be Used in All Patients?
abstract: It has been shown that mechanical ventilation by itself can cause lung injury and affect outcomes. Ventilator-induced lung injury is associated with high tidal volumes in lungs afflicted with ARDS. However, the question is: Do high tidal volumes have this same effect in normal lungs or lungs that have respiratory compromise stemming from something other than ARDS? Many clinicians believe that a tidal volume strategy of 6 mL/kg predicted body weight should be standard practice in all patients receiving mechanical ventilation. There is a growing body of evidence related to this issue, and this is the debate that will be tackled in this paper from both pro and con perspectives.
authors.affiliation: Respiratory Care Services, Duke University, Durham, North Carolina. john.davies@duke.edu mirelee@ccf.org.
authors.forename: John D
authors.initials: JD
authors.lastname: Davies
authors.affiliation: Respiratory Institute, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Mourad H
authors.initials: MH
authors.lastname: Senussi
authors.affiliation: Respiratory Institute, Cleveland Clinic, Cleveland, Ohio. john.davies@duke.edu mirelee@ccf.org.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Mireles-Cabodevila
mesh_terms: D006801:Humans; D008168:Lung / Q000503:physiopathology; D012121:Respiration, Artificial / Q000592:standards*; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D013990:Tidal Volume; D055397:Ventilator-Induced Lung Injury / Q000517:prevention & control*
keywords: ARDS; hypercapnia; lung-protective ventilation; mechanical ventilation; predicted body weight; strain; stress; tidal volume; time constant