title: Autophagy in acute brain injury.
abstract: Autophagy is an evolutionarily ancient mechanism that ensures the lysosomal degradation of old, supernumerary or ectopic cytoplasmic entities. Most eukaryotic cells, including neurons, rely on proficient autophagic responses for the maintenance of homeostasis in response to stress. Accordingly, autophagy mediates neuroprotective effects following some forms of acute brain damage, including methamphetamine intoxication, spinal cord injury and subarachnoid haemorrhage. In some other circumstances, however, the autophagic machinery precipitates a peculiar form of cell death (known as autosis) that contributes to the aetiology of other types of acute brain damage, such as neonatal asphyxia. Here, we dissect the context-specific impact of autophagy on non-infectious acute brain injury, emphasizing the possible therapeutic application of pharmacological activators and inhibitors of this catabolic process for neuroprotection.
authors.affiliation: Equipe 11 Labellisée Ligue Contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.|INSERM, U1138, 75006 Paris, France.|Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France.|Université Pierre et Marie Curie/Paris VI, 75006 Paris, France.|Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
authors.affiliation: Equipe 11 Labellisée Ligue Contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.|INSERM, U1138, 75006 Paris, France.|Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France.|Université Pierre et Marie Curie/Paris VI, 75006 Paris, France.|Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Bravo-San Pedro
authors.affiliation: Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital Q2:07, 17176 Stockholm, Sweden.
authors.forename: Klas
authors.initials: K
authors.lastname: Blomgren
authors.affiliation: Equipe 11 Labellisée Ligue Contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.|INSERM, U1138, 75006 Paris, France.|Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France.|Université Pierre et Marie Curie/Paris VI, 75006 Paris, France.|Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital Q2:07, 17176 Stockholm, Sweden.|Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France.|Pôle de Biologie, Hopitâl Européen George Pompidou, AP-HP, 75015 Paris, France.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D001930:Brain Injuries / Q000188:drug therapy / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000378:metabolism
chemical_list: D018696:Neuroprotective Agents