title: Steroid Hormone Receptor Coregulators in Endocrine Cancers.
abstract: Coregulators span a broad and extensive domain in modulating cellular transcriptional activity. Studies have established a dynamic role for such coregulators in various endocrine cancers. Steroid hormone receptors (SHRs) play a pivotal role in such endocrine cancers, and interact abundantly with transcriptional coregulators in altering gene expression. Several families of coregulators have implications in propagating the development, progression and invasion of breast, prostate, and other hormone-responsive cancers. This mini-review aims to discuss different classes of coregulators involved in endocrine cancers and highlight unique information regarding each family with relevance to mechanism, intervention, and novel directions being investigated. © 2016 IUBMB Life, 68(7):504-515, 2016.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Miami, FL, USA.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Obeid
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Miami, FL, USA.
authors.forename: Nawal
authors.initials: N
authors.lastname: Zafar
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Miami, FL, USA.
authors.forename: Jimmy
authors.initials: J
authors.lastname: El Hokayem
mesh_terms: D002352:Carrier Proteins / Q000235:genetics; D004701:Endocrine Gland Neoplasms / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D056920:Nuclear Receptor Coactivator 1 / Q000235:genetics; D050828:Protein Inhibitors of Activated STAT / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics*; D011987:Receptors, Steroid / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
chemical_list: D002352:Carrier Proteins; D050828:Protein Inhibitors of Activated STAT; D012333:RNA, Messenger; D011987:Receptors, Steroid; C548898:steroid receptor RNA activator, human; C538859:NCOA1 protein, human; D056920:Nuclear Receptor Coactivator 1; C471639:UBE3A protein, human; D044767:Ubiquitin-Protein Ligases
keywords: coregulator; endocrine cancer; hormone; nuclear receptors; steroid hormone receptor; transcriptional regulation