title: New insights into folliculotropic mycosis fungoides (FMF): A single-center experience.
abstract: BACKGROUND
  It is generally accepted that folliculotropic mycosis fungoides (FMF) is usually typified by indurated plaques and tumors mainly on the head/neck and an aggressive course. However, its clinical manifestations have long been recognized to be quite variable, and some studies indicate a better prognosis for certain presentations.
  
  
  OBJECTIVE
  We sought to summarize our experience with the clinicopathological presentations of FMF and impact on prognosis.
  
  
  METHODS
  Data were collected retrospectively for adults with FMF followed up prospectively at a tertiary medical center in 1995 through 2014.
  
  
  RESULTS
  In all, 34 patients presented with follicle-based patch/flat plaques, keratosis pilaris-like lesions, and/or acneiform lesions, defined clinically as early stage (IA, IB), and 15 presented with follicle-based infiltrated plaques and/or tumors, defined as advanced stage (IIB). The head/neck was involved in all tumor-stage cases, whereas early-stage lesions involved mainly the trunk/limbs. The tumor stage was characterized by more pruritus, heavier perifollicular infiltrates, greater vertical depth, and more frequent presence of eosinophils. On multivariate analysis, infiltrate density was the only significant histopathological discriminator between the stages. Estimated 5-year survival was 0.94 in the early-stage group and 0.69 in the tumor-stage group.
  
  
  CONCLUSIONS
  Lack of long-term follow-up and relatively small sample are limitations.
  
  
  CONCLUSIONS
  FMF presents with 2 distinct patterns of clinicopathologic features, early stage and advanced stage, each with different prognostic implications.
authors.affiliation: Department of Dermatology, Beilinson Hospital, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: hodake@post.tau.ac.il.
authors.forename: Emmilia
authors.initials: E
authors.lastname: Hodak
authors.affiliation: Department of Dermatology, Beilinson Hospital, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Iris
authors.initials: I
authors.lastname: Amitay-Laish
authors.affiliation: Department of Dermatology, Beilinson Hospital, Petah Tikva, Israel.
authors.forename: Lihi
authors.initials: L
authors.lastname: Atzmony
authors.affiliation: Department of Dermatology, Beilinson Hospital, Petah Tikva, Israel.
authors.forename: Hadas
authors.initials: H
authors.lastname: Prag-Naveh
authors.affiliation: Institute of Pathology, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.
authors.forename: Natalia
authors.initials: N
authors.lastname: Yanichkin
authors.affiliation: Department of Dermatology, Sheba Medical Center, Ramat Gan, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Aviv
authors.initials: A
authors.lastname: Barzilai
authors.affiliation: Department of Dermatology, Beilinson Hospital, Petah Tikva, Israel.
authors.forename: Ruben
authors.initials: R
authors.lastname: Kershenovich
authors.affiliation: Institute of Pathology, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Meora
authors.initials: M
authors.lastname: Feinmesser
mesh_terms: D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D011537:Pruritus / Q000209:etiology; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology*; D055815:Young Adult
keywords: cutaneous T-cell lymphoma; folliculotropic mycosis fungoides; histopathology; mycosis fungoides; prognosis