title: Arming the Immune System Through Vaccination to Prevent Cancer Recurrence.
abstract: Cancer vaccines have the potential to provide a nontoxic treatment for the prevention of cancer recurrence in the adjuvant setting. Many cancer vaccines have been tested in multiple phase III trials with minimal success. However, through these failed clinical trials, we have learned that the ideal setting for vaccine therapy is the adjuvant setting. Also, we have learned important lessons about patient selection to maximize the probability of success. This article will highlight some of the successes, our trial results in the adjuvant setting, and future directions.
authors.affiliation: From the Department of Surgery, San Antonio Military Medical Center, Fort Sam Houston, TX; Department of Surgery, Womack Army Medical Center, Fort Bragg, NC; Cancer Vaccine Development Program, San Antonio, TX; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD.
authors.forename: Diane F
authors.initials: DF
authors.lastname: Hale
authors.affiliation: From the Department of Surgery, San Antonio Military Medical Center, Fort Sam Houston, TX; Department of Surgery, Womack Army Medical Center, Fort Bragg, NC; Cancer Vaccine Development Program, San Antonio, TX; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Vreeland
authors.affiliation: From the Department of Surgery, San Antonio Military Medical Center, Fort Sam Houston, TX; Department of Surgery, Womack Army Medical Center, Fort Bragg, NC; Cancer Vaccine Development Program, San Antonio, TX; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD.
authors.forename: George E
authors.initials: GE
authors.lastname: Peoples
mesh_terms: D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use*; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination
chemical_list: D019496:Cancer Vaccines