title: Two new flavans from the trunk and leaves of Horsfieldia glabra.
abstract: Two new flavans, (2R, 4R)-4'-hydroxy-3',5'-methyl-6,7-methylenedioxy-4-O-2'-cycloflavan (1), and (2R, 4R)-4'-hydroxy-3'-methyl-6,7-methylenedioxy-4-O-2'-cycloflavan (2), along with six known compounds were isolated from the trunk and leaves of Horsfieldia glabra. Their structures were elucidated by means of extensive spectroscopic analysis. Compounds 1 and 2, together with 4-7 were assessed for their cytotoxicity against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that they had no activity.
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Peng
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
authors.forename: Caiqiong
authors.initials: C
authors.lastname: Yang
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhan
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Kunming , China.
authors.forename: Yegao
authors.initials: Y
authors.lastname: Chen
mesh_terms: D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D026324:Myristicaceae / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D013057:Spectrum Analysis
chemical_list: D001578:Benzopyrans; D005419:Flavonoids
keywords: Horsfieldia glabra; Myristicaceae; cycloflavan