title: Polymorphisms of interleukin-1β and MUC7 genes in burning mouth syndrome.
abstract: OBJECTIVE
  The objectives of the present study are to compare polymorphisms of the IL-1β and MUC7 genes between patients with burning mouth syndrome (BMS) and controls and to investigate relationships between these polymorphisms and clinical characteristics in BMS patients.
  
  
  METHODS
  Forty female BMS patients and 40 gender- and age-matched controls were included. Genomic DNA was extracted from saliva samples. Single-nucleotide polymorphisms of IL-1β -511 and +3954 and variation in number of tandem repeat (VNTR) polymorphism of MUC7 were analyzed. Relationships between genotypic polymorphism data and clinical characteristics in BMS patients were also analyzed.
  
  
  RESULTS
  There were no significant differences in the genotypes of IL-1β -511 and +3954 and of MUC7 between the groups. There were no significant differences in symptom duration and intensity of BMS patients according to their IL-1β and MUC7 genotypes. The T allele of IL-1β -511 showed associations with psychometry results in BMS patients: paranoid ideation (P = 0.014), Global Severity Index (P = 0.025), and Positive Symptom Total (P = 0.008).
  
  
  CONCLUSIONS
  The genotypic polymorphisms of IL-1β -511 and +3954, and of MUC7 VNTR, had no direct associations with the development of BMS. However, the T allele of IL-1β -511 may increase the risk of BMS by increasing psychological asthenia.
  
  
  CONCLUSIONS
  The genotypic polymorphisms of IL-1β -511 may increase the risk for the development of BMS by increasing psychological asthenia.
authors.affiliation: Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, Yunkeun-Dong 28, Chongro-Ku, Seoul, 110-749, Republic of Korea.
authors.forename: Moon-Jong
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, Yunkeun-Dong 28, Chongro-Ku, Seoul, 110-749, Republic of Korea.
authors.forename: Jihoon
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, Yunkeun-Dong 28, Chongro-Ku, Seoul, 110-749, Republic of Korea.
authors.forename: Ji-Youn
authors.initials: JY
authors.lastname: Chang
authors.affiliation: Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, Yunkeun-Dong 28, Chongro-Ku, Seoul, 110-749, Republic of Korea.
authors.forename: Yoon-Young
authors.initials: YY
authors.lastname: Kim
authors.affiliation: Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, Yunkeun-Dong 28, Chongro-Ku, Seoul, 110-749, Republic of Korea. hkho@snu.ac.kr.|Institute on Aging Seoul National University, Gwanak-Ro 1, Gwanak-Gu, Seoul, 151-742, Republic of Korea. hkho@snu.ac.kr.
authors.forename: Hong-Seop
authors.initials: HS
authors.lastname: Kho
mesh_terms: D002054:Burning Mouth Syndrome / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008875:Middle Aged; D009077:Mucins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012471:Salivary Proteins and Peptides / Q000235:genetics*
chemical_list: D053583:Interleukin-1beta; C083238:MUC7 protein, human; D009077:Mucins; D012471:Salivary Proteins and Peptides
keywords: Burning mouth syndrome; Interleukin-1β; MUC7; Polymorphism