title: Effects of Untreated Periodontitis on Osseointegration of Dental Implants in a Beagle Dog Model.
abstract: There have been previous studies on the relationship between periodontitis and peri-implantitis, but limited information is available on how periodontitis affects osseointegration and wound healing of newly placed dental implants adjacent to natural teeth. The objective of the present experiment is to evaluate healing around dental implants adjacent to teeth with untreated experimental periodontitis.
  
  
  
  The study included six male beagle dogs. Scaling and plaque control procedures were performed on three dogs (control group). In the other three dogs (experimental group), retraction cords and ligature wires were placed subgingivally around all premolars and the first molars. Induced experimental periodontitis was confirmed after 3 months. Each control or experimental group was divided into two subgroups depending on the timing of implant placement (immediate/delayed). Twelve dental implants (two implants for each dog) were placed immediately, and the other 12 dental implants (two implants for each dog) were placed 2 months after extraction. The animals were sacrificed 2 months after implant placement. Histologic and histometric analyses were performed.
  
  
  
  Four implants (three from the immediate placement group and one from the delayed placement group) failed in the experimental group. There were significant differences in the percentage of bone-to-implant contact and marginal bone volume density between the control and experimental groups. Both parameters were significantly lower in the experimental group than in the control group (P <0.05). There was a tendency toward more marginal bone loss in the experimental group than the control group.
  
  
  
  Immediate placement of implants is associated with a higher failure rate compared with delayed placement. Untreated experimental periodontitis was correlated with compromised osseointegration in the implants with delayed placement.
authors.affiliation: Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.
authors.forename: Daehyun
authors.initials: D
authors.lastname: Lee
authors.affiliation: Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.
authors.forename: Byungjin
authors.initials: B
authors.lastname: Sohn
authors.affiliation: Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.
authors.forename: Kyoung Hwa
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.
authors.forename: Sungtae
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.
authors.forename: Ki-Tae
authors.initials: KT
authors.lastname: Koo
authors.affiliation: Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.
authors.forename: Tae-Il
authors.initials: TI
authors.lastname: Kim
authors.affiliation: Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.
authors.forename: Yang-Jo
authors.initials: YJ
authors.lastname: Seol
authors.affiliation: Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.
authors.forename: Yong-Moo
authors.initials: YM
authors.lastname: Lee
authors.affiliation: Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.
authors.forename: In-Chul
authors.initials: IC
authors.lastname: Rhyu
authors.affiliation: Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.
authors.forename: Young
authors.initials: Y
authors.lastname: Ku
mesh_terms: D000818:Animals; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D017267:Dental Prosthesis Design; D004285:Dogs; D008297:Male; D008334:Mandible; D016348:Osseointegration; D010518:Periodontitis
chemical_list: D015921:Dental Implants
keywords: Bone–implant interface; dental implants; osseointegration; periodontitis