title: Comparison of the effects of patient controlled analgesia (PCA) using dexmedetomidine and propofol during septoplasty operations: a randomized clinical trial.
abstract: BACKGROUND
  Septoplastical surgery to correct septum deviation can be performed under either local or general anesthesia. During local anesthesia, sedation helps to provide minimum anxiety/discomfort. Our aim was to evaluate the effects of patient-controlled analgesia using dexmedetomidine and propofol on sedation level, analgesic requirement, and patient satisfaction.
  
  
  METHODS
  A prospective, randomized-parallel clinical study.
  
  
  METHODS
  Fifty patients undergoing septoplastical surgery at our university hospital were randomized into two groups. A nasopharyngeal cotton tampon soaked in 0.25 % adrenaline solution was placed, and 1 mg midazolam and 1 mcg/kg fentanyl were applied 5 min before the injections of a surgical local anesthetic. Loading dose was 0.5 mg/kg propofol (Group I) and 1 mcg/kg dexmedetomidine (Group II). The sedation was sustained by a bolus dose of 0.2 mg/kg and continuous basal infusion dose of 0.5 mg/kg/h propofol in Group I, or by a bolus dose of 0.05 µg/kg and continuous basal infusion dose of 0.4 mcg/kg/h dexmedetomidine in Group II. The primary outcomes were patient satisfaction via patient-controlled anesthesia and analgesic demand. Secondary outcomes were sedation level of patients under local anesthesia.
  
  
  RESULTS
  In Group II, SpO2 levels were significantly higher than in Group I. Intraoperative and postoperative analgesic requirements were lower in Group II than in Group I. There were no statistically significant differences in patient satisfaction, hemodynamic parameters, nausea and vomiting between the two groups.
  
  
  CONCLUSIONS
  Dexmedetomidine can be used safely as an analgesic and sedation drug in septoplastic surgery.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Hacettepe University, 06100 Sıhhiye, Ankara, Turkey.
authors.forename: Başak
authors.initials: B
authors.lastname: Akça
authors.affiliation: Department of Anesthesiology, Fatsa State Hospital, Ordu, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Arslan
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Hacettepe University, 06100 Sıhhiye, Ankara, Turkey.
authors.forename: Aysun Ankay
authors.initials: AA
authors.lastname: Yılbaş
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Hacettepe University, 06100 Sıhhiye, Ankara, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Canbay
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Hacettepe University, 06100 Sıhhiye, Ankara, Turkey.
authors.forename: Nalan
authors.initials: N
authors.lastname: Çelebi