title: Computational fluid dynamics-based study of possibility of generating pulsatile blood flow via a continuous-flow VAD.
abstract: Until recent years, it was almost beyond remedy to save the life of end-stage heart failure patients without considering a heart transplant. This is while the need for healthy organs has always far exceeded donations. However, the evolution of VAD technology has certainly changed the management of these patients. Today, blood pumps are designed either pulsatile flow or continuous flow, each of which has its own concerns and limitations. For instance, pulsatile pumps are mostly voluminous and hardly can be used for children. On the other hand, the flow generated by continuous-flow pumps is in contrast with pulsatile flow of the natural heart. In this project, having used computational fluid dynamics, we studied the possibility of generating pulsatile blood flow via a continuous-flow blood pump by adjusting the rotational speed of the pump with two distinct patterns (sinusoidal and trapezoidal), both of which have been proposed and set based on physiological needs and blood flow waveform of the natural heart. An important feature of this study is setting the outlet pressure of the pump similar to the physiological conditions of a patient with heart failure, and since these axial pumps are sensitive to outlet pressures, more secure and reliable results of their performance are achieved. Our results show a slight superiority of a sinusoidal pattern compared to a trapezoidal one with the potential to achieve an adequate pulsatile flow by precisely controlling the rotational speed.
authors.affiliation: Division of Biomechanics, Department of Mechanical Engineering, Sahand University of Technology, Sahand New Town, Tabriz, Iran.
authors.forename: Erfan
authors.initials: E
authors.lastname: Nammakie
authors.affiliation: Division of Biomechanics, Department of Mechanical Engineering, Sahand University of Technology, Sahand New Town, Tabriz, Iran. niroomand@sut.ac.ir.
authors.forename: Hanieh
authors.initials: H
authors.lastname: Niroomand-Oscuii
authors.affiliation: Division of Biomechanics, Department of Mechanical Engineering, Sahand University of Technology, Sahand New Town, Tabriz, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Koochaki
authors.affiliation: Division of Biomechanics, Department of Mechanical Engineering, Sahand University of Technology, Sahand New Town, Tabriz, Iran.
authors.forename: Farzan
authors.initials: F
authors.lastname: Ghalichi
mesh_terms: D006353:Heart-Assist Devices; D006439:Hemodynamics; D006461:Hemolysis; D006801:Humans; D057446:Hydrodynamics; D009716:Numerical Analysis, Computer-Assisted; D011312:Pressure; D011673:Pulsatile Flow; D012399:Rotation; D013314:Stress, Mechanical
keywords: CFD; Hemolysis; Pulsatile flow; Ventricular assist device