title: MRI as a tool for non-invasive vascular profiling: a pilot study in patients with aortic coarctation.
abstract: OBJECTIVE
  While the overall concept of aortic coarctation has changed from one of simple obstruction to one that includes significant vascular dysfunction, this has not yet been translated into the diagnostic and treatment process. To close this gap, we sought to demonstrate the usefulness of an additional non-invasive vascular profile.
  
  
  METHODS
  During a pilot study in eight coarctation patients, aortic area compliance, aortic distensibility, time phase shift and blood flow (distribution) were calculated from cine-MRI and 2D-/4D-velocity-encoded MRI sequences.
  
  
  RESULTS
  Compared to healthy individuals, a significantly lower aortic compliance and reduced flow to the descending aorta were found in patients with coarctation.
  
  
  CONCLUSIONS
  These differences underline the potential usefulness of a combined vascular profile in coarctation patients.
  
  
  CONCLUSIONS
  It was successfully shown that functional vascular profiling of the aorta is feasible to be acquired non-invasively in a clinical setting and can provide additional diagnostic information. These can be the key input parameters for computational fluid dynamics-modeling.
authors.forename: Marcus
authors.initials: M
authors.lastname: Kelm
authors.forename: Leonid
authors.initials: L
authors.lastname: Goubergrits
authors.forename: Joao Filipe
authors.initials: JF
authors.lastname: Fernandes
authors.forename: Lucio
authors.initials: L
authors.lastname: Biocca
authors.forename: Giacomo
authors.initials: G
authors.lastname: Pongiglione
authors.forename: Vivek
authors.initials: V
authors.lastname: Muthurangu
authors.forename: Abbas
authors.initials: A
authors.lastname: Khushnood
authors.forename: Aurelio
authors.initials: A
authors.lastname: Secinaro
authors.forename: Marcello
authors.initials: M
authors.lastname: Chinali
authors.forename: Stephan
authors.initials: S
authors.lastname: Schubert
authors.forename: Felix
authors.initials: F
authors.lastname: Berger
authors.forename: Titus
authors.initials: T
authors.lastname: Kuehne
mesh_terms: D000293:Adolescent; D000328:Adult; D001011:Aorta / Q000503:physiopathology*; D001013:Aorta, Thoracic / Q000503:physiopathology*; D001017:Aortic Coarctation / Q000175:diagnosis* / Q000503:physiopathology; D001794:Blood Pressure; D001795:Blood Pressure Determination; D016022:Case-Control Studies; D002648:Child; D003187:Compliance; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010865:Pilot Projects; D013997:Time Factors; D055815:Young Adult