title: [The morphofunctional features of the heart associated with acute morphine poisoning during the period of chronic drug intoxication].
abstract: The objective of the present study was to improve forensic medical diagnostics of the cases of death associated with morphine poisoning based on the investigation into the biochemical changes in blood and pericardial fluid as well as morphological changes in the myocardial structures. The studies were carried out with the use of thin-layer chromatography, colorimetric and morphological methods including hematoxylin and eosin, Lee's methylene blue, and van Gieson's picrofuscin staining. These techniques were supplemented by light and polarization microscopy. The study has demonstrated the presence of morphine in 99.16% of the blood and pericardial samples obtained in the cases of poisoning. The comparison of the results of biochemical and pathomorphological studies of the myocardium made it possible to evaluate the functional and morphological conditions of the heart in the case of acute morphine poisoning during the period of chronic drug intoxication.
authors.affiliation: Centre of Forensic Medicine, Kazakh Ministry of Justice, Almaty, Republic of Kazakhstan, 050000.
authors.forename: A Zh
authors.initials: AZ
authors.lastname: Altaeva
authors.affiliation: Astana Medical University, Kazakh Ministry of Health, Astana, Republic of Kazakhstan, 010000.
authors.forename: F A
authors.initials: FA
authors.lastname: Galitskiy
authors.affiliation: Astana Medical University, Kazakh Ministry of Health, Astana, Republic of Kazakhstan, 010000.
authors.forename: T Z
authors.initials: TZ
authors.lastname: Zhakupova
authors.affiliation: Centre of Forensic Medicine, Kazakh Ministry of Justice, Almaty, Republic of Kazakhstan, 050000.
authors.forename: A Sh
authors.initials: AS
authors.lastname: Aidarkulov
authors.affiliation: Centre of Forensic Medicine, Kazakh Ministry of Justice, Almaty, Republic of Kazakhstan, 050000.
authors.forename: N V
authors.initials: NV
authors.lastname: Selivokhina
authors.affiliation: Centre of Forensic Medicine, Kazakh Ministry of Justice, Almaty, Republic of Kazakhstan, 050000.
authors.forename: S S
authors.initials: SS
authors.lastname: Zhunisov
mesh_terms: D000293:Adolescent; D000328:Adult; D002855:Chromatography, Thin Layer / Q000379:methods; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D049429:Forensic Pathology / Q000379:methods; D053593:Forensic Toxicology / Q000379:methods; D006801:Humans; D008297:Male; D009020:Morphine / Q000032:analysis / Q000506:poisoning; D009021:Morphine Dependence / Q000150:complications / Q000175:diagnosis; D009206:Myocardium / Q000473:pathology*; D009294:Narcotics / Q000032:analysis / Q000506:poisoning
chemical_list: D009294:Narcotics; D009020:Morphine