title: Anti-inflammatory and Anti-resorptive Effects of Atorvastatin on Alveolar Bone Loss in Wistar Rats.
abstract: The aim of this study was to evaluate the anti-inflammatory and anti-resorptive effect of atorvastatin (ATV) in an experimental alveolar bone loss (ABL) model. Wistar rats were subjected to ligature placement around the maxillary second molar for 11 days. The animals received 0.9% saline (2 mL/kg) or ATV (0.3, 3 or 27 mg/kg) daily by gavage. ABL was evaluated by resorption area and histopathological analysis. Serum bone-specific alkaline phosphatase (BALP) activity was also evaluated. Leukogram was performed at 0 h, 6th h, 2nd, 7th and 11th days. Kidney and liver conditions and the body mass variation were analyzed. ATV (3 and 27 mg/kg) inhibited ABL by 39% and 56%, respectively. Histopathological analysis showed that ATV 27 mg/kg prevented ABL and cemental resorption, and inflammatory cell infiltration induced by ligature. ATV (27 mg/kg) prevented serum BALP levels reduction. ATV (27 mg/kg) prevented leukocytosis and did not affect either kidney or liver function nor body mass weight. ATV showed a protecting effect in the ligature-induced periodontitis, without affecting system parameters, by inhibition of inflammatory process and by its anabolic activity on the alveolar bone.
authors.affiliation: Department of Pathology and Legal Medicine, UFC - Universidade Federal do Ceará, Fortaleza, CE, Brazil, Universidade Federal do Ceará, Department of Pathology and Legal Medicine, Universidade Federal do Ceará, Fortaleza CE , Brazil.
authors.forename: Paula
authors.initials: P
authors.lastname: Goes
authors.affiliation: Department of Physiology and Pharmacology, UFC - Universidade Federal do Ceará, Fortaleza, CE, Brazil, Universidade Federal do Ceará, Department of Physiology and Pharmacology, Universidade Federal do Ceará, Fortaleza CE , Brazil.
authors.forename: Neiberg Alcântara
authors.initials: NA
authors.lastname: Lima
authors.affiliation: Department of Biochemistry and Molecular Biology, UFC - Universidade Federal do Ceará, Fortaleza, CE, Brazil, Universidade Federal do Ceará, Department of Biochemistry and Molecular Biology, Universidade Federal do Ceará, Fortaleza CE , Brazil.
authors.forename: José Ariévilo Gurgel
authors.initials: JA
authors.lastname: Rodrigues
authors.affiliation: Department of Biochemistry and Molecular Biology, UFC - Universidade Federal do Ceará, Fortaleza, CE, Brazil, Universidade Federal do Ceará, Department of Biochemistry and Molecular Biology, Universidade Federal do Ceará, Fortaleza CE , Brazil.
authors.forename: Norma Maria Barros
authors.initials: NM
authors.lastname: Benevides
authors.affiliation: Department of Morphology, UFC - Universidade Federal do Ceará, Fortaleza, CE, Brazil, Universidade Federal do Ceará, Department of Morphology, Universidade Federal do Ceará, Fortaleza CE , Brazil.
authors.forename: Gerly Anne Castro
authors.initials: GA
authors.lastname: Brito
authors.affiliation: Department of Physiology and Pharmacology, UFC - Universidade Federal do Ceará, Fortaleza, CE, Brazil, Universidade Federal do Ceará, Department of Physiology and Pharmacology, Universidade Federal do Ceará, Fortaleza CE , Brazil.
authors.forename: Vilma
authors.initials: V
authors.lastname: Lima
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D016301:Alveolar Bone Loss; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000069059:Atorvastatin / Q000494:pharmacology*; D001862:Bone Resorption / Q000517:prevention & control*; D001842:Bone and Bones / Q000201:enzymology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D000069059:Atorvastatin; D000469:Alkaline Phosphatase