title: Endocrine prevention of chemotherapy-induced ovarian failure.
abstract: Fertility preservation has recently gained a worldwide interest among fertility specialists, oncologists, and all healthcare providers. Thus, the protection against iatrogenic infertility caused by chemotherapy assumes a high priority. Specifically, the issue of endocrine prevention of gonadotoxicity is still a controversial subject.
  
  
  
  During the last year, many publications on this subject appeared, swinging the pendulum toward the beneficial role of gonadotropin-releasing hormone agonist (GnRHa) cotreatment for fertility preservation despite gonadotoxic chemotherapy. Here, we summarize the recent publications on fertility preservation and minimizing chemotherapy-induced gonadotoxicity.
  
  
  
  More than 10 recent meta-analyses have concluded that GnRHa is beneficial and may decrease the risk of premature ovarian failure and increase the pregnancy rate in survivors. Furthermore, two recent international meetings of experts have concluded that GnRHa is effective and should be offered to every young woman facing gonadotoxic chemotherapy.
authors.affiliation: Reproductive Endocrinology, Rappaport Faculty of Medicine, Rambam Health Care Campus, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Zeev
authors.initials: Z
authors.lastname: Blumenfeld
authors.forename: Ayelet
authors.initials: A
authors.lastname: Evron
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005298:Fertility / Q000187:drug effects; D059247:Fertility Preservation / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D006801:Humans; D007246:Infertility / Q000517:prevention & control*; D015201:Meta-Analysis as Topic; D009369:Neoplasms / Q000188:drug therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced* / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents; D007987:Gonadotropin-Releasing Hormone