title: Liver transplantation followed by autologous stem cell transplantation for acute liver failure caused by AL amyloidosis. Case report and review of the literature.
abstract: Hepatic involvement in AL amyloidosis may present as acute liver failure. Historically, liver transplantation in these cases has achieved poor outcomes due to progress of amyloidosis and non-hepatic organ damage. In the era of bortezomib treatment, the prognosis of AL amyloidosis has been markedly improved and may also result in better post-transplant outcomes. We present a case of isolated acute liver failure caused by AL amyloidosis, bridged to transplantation with bortezomib and treated with sequential orthotopic liver transplantation (OLT) and autologous stem cell transplantation. The patient is in stable remission 3 years after OLT.
authors.affiliation: 2nd Medical Department, Klinikum rechts der Isar, Technische Universität München, Germany and Kasr Alainy Hospital, Department of Infectious Diseases and Endemic Hepatology and Gastroenterology, Cairo University, Cairo, Egypt.
authors.forename: Mayada
authors.initials: M
authors.lastname: Elnegouly
authors.affiliation: Institute of Pathology, § Department of Surgery, || 3rd Medical Department, ¶ 2nd Medical Department. Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Specht
authors.affiliation: Universitätsklinik für Innere Medizin II, Universität Innsbruck, Innsbruck, Austria.
authors.forename: Heinz
authors.initials: H
authors.lastname: Zoller
authors.affiliation: Department of Surgery Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Edouard
authors.initials: E
authors.lastname: Matevossian
authors.affiliation: Universität Innsbruck, Innsbruck, Austria.
authors.forename: Florian
authors.initials: F
authors.lastname: Bassermann
authors.affiliation: 2nd Medical Department. Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Umgelter
mesh_terms: D000686:Amyloidosis / Q000150:complications / Q000628:therapy*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000069286:Bortezomib / Q000627:therapeutic use*; D006801:Humans; D000075363:Immunoglobulin Light-chain Amyloidosis; D017114:Liver Failure, Acute / Q000209:etiology / Q000628:therapy*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D014182:Transplantation, Autologous
chemical_list: D000970:Antineoplastic Agents; D000069286:Bortezomib