title: Should total gastrectomy and total colectomy be considered for selected patients with severe tumor burden of pseudomyxoma peritonei in cytoreductive surgery?
abstract: This study aims to evaluate the safety and efficacy of cytoreductive surgery (CRS) including total gastrectomy and total colectomy in selected pseudomyxoma peritonei (PMP) patients with entire stomach and colon covered by mucinous tumor.
  
  
  
  A total of 48 patients received this extensive treatment between January 2006 and January 2014. The main focus of this study was survival after CRS as well as perioperative morbidity and mortality.
  
  
  
  Twenty-eight patients were male, and median age was 52.5 years. Median peritoneal cancer index was 33. Complete cytoreduction was achieved in all 48 patients, and 26 patients received hyperthermic intraperitoneal chemotherapy (HIPEC). Until last follow-up, the estimated median survival after CRS was 54.0 months (95% CI 36.5-71.6 months). The 1-, 2-, 3-, and 5-year survival rates were 91.7%, 81.3%, 70.1%, and 48.6%, respectively. Histology was significantly associated with survival (P = 0.020). The median disease-free survival was 32.0 (95% CI 25.7-38.3) months. HIPEC (P = 0.048) and histology (P = 0.002) was significantly associated with disease-free survival after CRS. Overall Grade 3-5 complications occurred in 18 (37.5%) patients with mortality of 2.1%. For patients who received surgery over 6 months, they could gradually have an acceptable quality-of-life similar as other patients receiving ordinary CRS and HIPEC.
  
  
  
  CRS including total gastrectomy and total colectomy can be performed in experienced specialized institutions as a feasible option to achieve complete cytoreduction with acceptable safety in selected PMP patients with stomach and colon covered by mucinous tumor. Perioperative management should be carried out cautiously to decrease and avoid complications.
authors.affiliation: NPO to Support Peritoneal Surface Malignancy Treatment, Grand Court Room 903, Fukushima-Cho 510, Shimogyo-Ku, Kyoto, 600-8189, Japan; Peritoneal Dissemination Center, Kishiwada Tokushukai Hospital, 4-27-1, Kamori-cho, Kishiwada City, Osaka, 596-8522, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of General Surgery, Kusatsu General Hospital, 1660, Yabase-machi, Kusatsu City, Shiga, 525-8585, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Mizumoto
authors.affiliation: NPO to Support Peritoneal Surface Malignancy Treatment, Grand Court Room 903, Fukushima-Cho 510, Shimogyo-Ku, Kyoto, 600-8189, Japan; Peritoneal Dissemination Center, Kishiwada Tokushukai Hospital, 4-27-1, Kamori-cho, Kishiwada City, Osaka, 596-8522, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ishibashi
authors.affiliation: NPO to Support Peritoneal Surface Malignancy Treatment, Grand Court Room 903, Fukushima-Cho 510, Shimogyo-Ku, Kyoto, 600-8189, Japan; Peritoneal Dissemination Center, Kishiwada Tokushukai Hospital, 4-27-1, Kamori-cho, Kishiwada City, Osaka, 596-8522, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takeshita
authors.affiliation: Department of General Surgery, Kusatsu General Hospital, 1660, Yabase-machi, Kusatsu City, Shiga, 525-8585, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hirano
authors.affiliation: Department of General Surgery, Kusatsu General Hospital, 1660, Yabase-machi, Kusatsu City, Shiga, 525-8585, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ichinose
authors.affiliation: NPO to Support Peritoneal Surface Malignancy Treatment, Grand Court Room 903, Fukushima-Cho 510, Shimogyo-Ku, Kyoto, 600-8189, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takegawa
authors.affiliation: NPO to Support Peritoneal Surface Malignancy Treatment, Grand Court Room 903, Fukushima-Cho 510, Shimogyo-Ku, Kyoto, 600-8189, Japan; Peritoneal Dissemination Center, Kishiwada Tokushukai Hospital, 4-27-1, Kamori-cho, Kishiwada City, Osaka, 596-8522, Japan; Department of General Surgery, Kusatsu General Hospital, 1660, Yabase-machi, Kusatsu City, Shiga, 525-8585, Japan. Electronic address: y.yonemura@coda.ocn.ne.jp.
authors.forename: Y
authors.initials: Y
authors.lastname: Yonemura
mesh_terms: D018784:Abdominal Abscess / Q000209:etiology; D000328:Adult; D000368:Aged; D057868:Anastomotic Leak / Q000209:etiology; D003082:Colectomy / Q000009:adverse effects / Q000379:methods / Q000592:standards; D065426:Cytoreduction Surgical Procedures; D018572:Disease-Free Survival; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects / Q000379:methods / Q000592:standards; D006801:Humans; D007239:Infections / Q000209:etiology; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000209:etiology; D011553:Pseudomyxoma Peritonei / Q000401:mortality / Q000601:surgery*; D012131:Respiratory Insufficiency / Q000209:etiology; D047368:Tumor Burden
keywords: Cytoreductive surgery; Hyperthermic intraperitoneal chemotherapy; Peritonectomy; Pseudomyxoma peritonei; Total colectomy; Total gastrectomy