title: Total synthesis of desoxycyclomarin C and the cyclomarazines A and B.
abstract: Removing the β-hydroxy group from the prenylated tryptophan moiety of cyclomarins simplifies the synthesis of these interesting natural products significantly, without having a noteworthy effect on the anti-tuberculosis activity of the cyclomarins. In contrast, cyclomarazines did not show biological activity.
authors.affiliation: Institute of Organic Chemistry, Saarland University, P.O. Box 151150, 66041 Saarbrücken, Germany. u.kazmaier@mx.uni-saarland.de.
authors.forename: Philipp
authors.initials: P
authors.lastname: Barbie
authors.forename: Uli
authors.initials: U
authors.lastname: Kazmaier
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D054876:Prenylation
chemical_list: D000995:Antitubercular Agents; D001688:Biological Products; D010456:Peptides, Cyclic; C000626268:desoxycyclomarin C