title: Mobitz type I and II atrioventricular blocks during fingolimod therapy.
abstract: We investigated patients who showed a second-degree atrioventricular block (S-AVB) after the first fingolimod administration. We observed six patients with S-AVB, three Mobitz type I, and three type II. Monitoring continued on the second day for all patients. Three patients showed persistence of the S-AVB, with resolution on the second or third day. One patient had a persistent S-AVB up to the fourth day when fingolimod was discontinued. We conclude that Mobitz type II S-AVB is possible during fingolimod therapy. Patients with S-AVB could be monitored until resolution of the S-AVBs, as these may persist several days after the first fingolimod administration.
authors.affiliation: Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy. francesco.sacca@unina.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Saccà
authors.affiliation: Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Puorro
authors.affiliation: Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Marsili
authors.affiliation: Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Pane
authors.affiliation: Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy.
authors.forename: Cinzia Valeria
authors.initials: CV
authors.lastname: Russo
authors.affiliation: Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Lanzillo
authors.affiliation: Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: de Rosa
authors.affiliation: Department of Translational Medical Sciences, University Federico II, Naples, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cittadini
authors.affiliation: U.O.C. Cardiologia e UTIC, ASST Rhodense, Garbagnate Milanese, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Angelis
authors.affiliation: Department of Neurosciences, Reproductive and Odontostomatological Sciences, University Federico II, Via Pansini, 5, 80131, Naples, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Brescia Morra
mesh_terms: D000328:Adult; D054537:Atrioventricular Block / Q000139:chemically induced* / Q000145:classification / Q000175:diagnosis; D004562:Electrocardiography; D004569:Electroencephalography; D005260:Female; D000068876:Fingolimod Hydrochloride / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D000068876:Fingolimod Hydrochloride
keywords: Atrioventricular block; Cardiac safety; Fingolimod; Mobitz type II; Multiple sclerosis; Relapsing; Tolerability; Treatment