title: Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae.
abstract: A new para-aminobenzoic-acid-containing natural product from the mango pathogenic organism Xanthomonas citri pv. mangiferaeindicae is described. By means of stable isotope precursor feeding combined with nontargeted LC-MS/MS, the generated spectra were clustered and visualized in a molecular network. This led to the identification of a new member of the meroterpenoids, termed xanthomonic acid, which is composed of an isoprenylated para-aminobenzoic acid. In vitro cytotoxicity assays demonstrated activity of xanthomonic acid against several human cancer cell lines by induction of autophagy.
authors.affiliation: Institut für Chemie, Technische Universität Berlin , Strasse des 17. Juni 124, 10623 Berlin, Germany.
authors.forename: Hesham
authors.initials: H
authors.lastname: Saleh
authors.affiliation: Institut für Chemie, Technische Universität Berlin , Strasse des 17. Juni 124, 10623 Berlin, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Petras
authors.affiliation: Institut für Chemie, Technische Universität Berlin , Strasse des 17. Juni 124, 10623 Berlin, Germany.
authors.forename: Andi
authors.initials: A
authors.lastname: Mainz
authors.affiliation: Institut für Chemie, Technische Universität Berlin , Strasse des 17. Juni 124, 10623 Berlin, Germany.
authors.forename: Dennis
authors.initials: D
authors.lastname: Kerwat
authors.affiliation: Department of Bioengineering, Faculty of Engineering, Ege University , 35100 Bornova Izmir, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Nalbantsoy
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Ege University , 35100 Bornova Izmir, Turkey.
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Erzurumlu
authors.affiliation: Institut für Chemie, Technische Universität Berlin , Strasse des 17. Juni 124, 10623 Berlin, Germany.
authors.forename: Roderich D
authors.initials: RD
authors.lastname: Süssmuth
mesh_terms: D010129:4-Aminobenzoic Acid / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001343:Autophagy / Q000187:drug effects; D003903:Deuterium / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D031022:Mangifera / Q000382:microbiology*; D015394:Molecular Structure; D010935:Plant Diseases / Q000382:microbiology*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014974:Xanthomonas / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D013729:Terpenes; C000618513:xanthomonic acid; D003903:Deuterium; D010129:4-Aminobenzoic Acid