title: A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem Cells.
abstract: Adipose-derived stem cells (ADSCs) are ideal seed cells for use in bone tissue engineering and they have many advantages over other stem cells. In this study, two kinds of calcium phosphate/collagen composite scaffolds were prepared and their effects on the proliferation and osteogenic differentiation of ADSCs were investigated. The hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) composite scaffolds (HTPSs), which have an additional β-tricalcium phosphate, resulted in better proliferation of ADSCs and showed osteogenesis-promoting effects. Therefore, such composite scaffolds, in combination with ADSCs or on their own, would be promising for use in bone regeneration and potential clinical therapy for bone defects.
authors.affiliation: National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China; Center of Digital Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China; 2nd Dental Center, Peking University School and Hospital of Stomatology, Beijing 100101, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: 2nd Dental Center, Peking University School and Hospital of Stomatology, Beijing 100101, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.affiliation: Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Gui-Feng
authors.initials: GF
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yu
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhou
authors.affiliation: National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China; 2nd Dental Center, Peking University School and Hospital of Stomatology, Beijing 100101, China.
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Tang