title: Histopathology of Graft-vs-Host Disease of Gastrointestinal Tract and Liver:  An Update.
abstract: OBJECTIVE
  Graft-vs-host disease (GVHD) is a donor T-cell-mediated disorder affecting the recipient's skin, gastrointestinal tract, lungs, and liver. It complicates up to 70% of hematopoietic cell transplantation and is associated with high morbidity and mortality rates.
  
  
  METHODS
  An extensive review of the literature has been performed to include the most current consensus on the histopathologic diagnosis of gastrointestinal and liver GVHD.
  
  
  RESULTS
  In this review, we present an overview of GVHD, with emphasis on the histopathologic evaluation of gastrointestinal and liver specimens, including the most important differential diagnoses and possible pitfalls.
  
  
  CONCLUSIONS
  Histopathologic examination remains the mainstay of diagnosis of gastrointestinal and liver GVHD and is interpreted in conjunction with clinical and laboratory data.
authors.affiliation: From the Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY; mas2300@cumc.columbia.edu.
authors.forename: Marcela
authors.initials: M
authors.lastname: Salomao
authors.affiliation: Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh Medical Center and the University of Pittsburgh Cancer Institute, Pittsburgh, PA;
authors.forename: Kathleen
authors.initials: K
authors.lastname: Dorritie
authors.affiliation: Department of Medicine, Division of Hematology/Oncology, Columbia University College of Physicians and Surgeons, New York, NY.
authors.forename: Markus Y
authors.initials: MY
authors.lastname: Mapara
authors.affiliation: From the Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY;
authors.forename: Antonia
authors.initials: A
authors.lastname: Sepulveda
mesh_terms: D041981:Gastrointestinal Tract / Q000473:pathology*; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008099:Liver / Q000473:pathology*
keywords: GVHD; Gastrointestinal pathology; Graft-vs-host disease; Liver pathology