title: Essential role of miRNAs in orchestrating the biology of the tumor microenvironment.
abstract: MicroRNAs (miRNAs) are emerging as central players in shaping the biology of the Tumor Microenvironment (TME). They do so both by modulating their expression levels within the different cells of the TME and by being shuttled among different cell populations within exosomes and other extracellular vesicles. This review focuses on the state-of-the-art knowledge of the role of miRNAs in the complexity of the TME and highlights limitations and challenges in the field. A better understanding of the mechanisms of action of these fascinating micro molecules will lead to the development of new therapeutic weapons and most importantly, to an improvement in the clinical outcome of cancer patients.
authors.affiliation: Children's Center for Cancer and Blood Diseases and The Saban Research Institute, Children's Hospital, Los Angeles, Los Angeles, CA, USA.
authors.forename: Jamie N
authors.initials: JN
authors.lastname: Frediani
authors.affiliation: Children's Center for Cancer and Blood Diseases and The Saban Research Institute, Children's Hospital, Los Angeles, Los Angeles, CA, USA. mfabbri@chla.usc.edu.|Departments of Pediatrics and Molecular Microbiology & Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. mfabbri@chla.usc.edu.|, 4650 Sunset Blvd MS #57, Los Angeles, CA, 90027, USA. mfabbri@chla.usc.edu.
authors.forename: Muller
authors.initials: M
authors.lastname: Fabbri
mesh_terms: D000818:Animals; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D055354:Exosomes / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D034443:RNA Transport; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D059016:Tumor Microenvironment / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: Cancer; Exosomes; Tumor microenvironment; microRNAs