title: Should Airway Pressure Release Ventilation Be the Primary Mode in ARDS?
abstract: Airway pressure release ventilation (APRV) was originally described as a mode to treat lung-injured patients with the goal to maintain a level of airway pressure that would not depress the cardiac function, deliver mechanical breaths without excessive airway pressure, and to allow unrestricted spontaneous ventilation. Indeed, based on its design, APRV has technological features that serve the goals of safety and comfort. Animal studies suggest that APRV leads to alveolar stability and recruitment which result in less lung injury. These features are sought in patients at risk for lung injury or with ARDS. APRV allows unrestricted spontaneous ventilation, which is welcome in the era of less sedation and increased patient mobility (the effects in terms of lung injury remain to be explored). However, we must highlight that the performance of APRV is dependent on the operator-selected settings and the ventilator's performance. The clinician must select the appropriate settings in order to make effective the imputed benefits. This is a challenge when the ventilator's performance is not uniform, and the outcomes depend on high precision settings (very short expiratory time), where small variations can lead to undesired outcomes (de-recruitment or large tidal volumes leading to lung injury). Finally, we do not have evidence that APRV (as originally described) improves relevant clinical outcomes of patients with ARDS. For APRV to become the primary mode of ventilation for ARDS, it will require development of sound protocols and technological enhancements to ensure its performance and safety. For now, APRV does have a greater potential for adversely affecting patient outcome than improving it; unless definitive data are forthcoming demonstrating outcome benefits from the use of APRV in ARDS, there is no reason to consider this approach to ventilatory support.
authors.affiliation: Respiratory Institute, Cleveland Clinic, Cleveland, Ohio. mirelee@ccf.org rkacmarek@partners.org.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Mireles-Cabodevila
authors.affiliation: Respiratory Care Services, Massachusetts General Hospital, Boston, Massachusetts. mirelee@ccf.org rkacmarek@partners.org.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Kacmarek
mesh_terms: D000818:Animals; D045422:Continuous Positive Airway Pressure / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D012119:Respiration; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D055397:Ventilator-Induced Lung Injury / Q000517:prevention & control*
keywords: Airway pressure release ventilation; auto PEEP; biphasic positive-pressure breathing; lung injury; work of breathing