title: The role of IL-37 in cancer.
abstract: Interleukin 37 (IL-37) is a new member of the IL-1 family which all have a similar β-barrel structure. Since its discovery, IL-37 has been studied extensively in immunological field. It has been established that IL-37 possesses anti-inflammatory characteristics both in innate immune response as well as in acquired immune responses by downregulating pro-inflammatory molecules. This review will discuss the role of IL-37 in immunological processes and neoplastic pathogenesis.
authors.affiliation: Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA, 50312, USA.
authors.forename: Vivi A
authors.initials: VA
authors.lastname: Ding
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
authors.forename: Ziwen
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: The Affiliated Hospital of Xiangnan University, Chenzhou, Hunan, China.
authors.forename: Huaping
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Wakefield
authors.affiliation: Department of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, USA.
authors.forename: Qian
authors.initials: Q
authors.lastname: Bai
authors.affiliation: Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA, 50312, USA. yujiang.fang@dmu.edu.|Department of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, USA. yujiang.fang@dmu.edu.
authors.forename: Yujiang
authors.initials: Y
authors.lastname: Fang
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology; D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007375:Interleukin-1 / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*
chemical_list: C508587:IL37 protein, human; D007375:Interleukin-1
keywords: Cancer; IL-37; Immunity