title: LMO2 and IL2RG synergize in thymocytes to mimic the evolution of SCID-X1 gene therapy-associated T-cell leukaemia.
authors.affiliation: Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, UK.
authors.forename: K
authors.initials: K
authors.lastname: Ruggero
authors.affiliation: Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, UK.
authors.forename: O
authors.initials: O
authors.lastname: Al-Assar
authors.affiliation: Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Chambers
authors.affiliation: Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, UK.|ABeterno Technologies Ltd, Cambridge, UK.
authors.forename: R
authors.initials: R
authors.lastname: Codrington
authors.affiliation: Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, UK.
authors.forename: T
authors.initials: T
authors.lastname: Brend
authors.affiliation: Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, UK.
authors.forename: T H
authors.initials: TH
authors.lastname: Rabbitts
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000818:Animals; D015316:Genetic Therapy / Q000009:adverse effects*; D053631:Interleukin Receptor Common gamma Subunit / Q000235:genetics*; D060588:LIM Domain Proteins / Q000235:genetics*; D015458:Leukemia, T-Cell / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D060168:Thymocytes / Q000473:pathology; D053632:X-Linked Combined Immunodeficiency Diseases
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C507942:Il2rg protein, mouse; D053631:Interleukin Receptor Common gamma Subunit; D060588:LIM Domain Proteins; C513188:Lmo2 protein, mouse