title: [Medicines and frailty in older people. Towards a new nosological entity: A pharmacological frailty?].
abstract: Frailty is a complex geriatric syndrome linked to the overall decrease of physiological reserves. It could lead to disability and to an increase in mortality. Frailty could have an impact on the effect and on the use of medications. Drugs could also affect the frailty process. Currently, no specific guidelines exist for appropriately prescribing medications to frail older people. The aim of this paper is to explore the body of current knowledge about the relationship between drugs and frailty in older people and to introduce a new nosological entity: pharmacological frailty.
authors.affiliation: Service de médecine gériatrique, pôle clinique médicale et gérontologie clinique, centre hospitalier universitaire, 87042 Limoges, France; EA6310, handicap activité, vieillissement, autonomie, environnement (HAVAE), université de Limoges, 87042 Limoges, France.
authors.forename: Hichem
authors.initials: H
authors.lastname: Nessighaoui
authors.affiliation: Centre régional de pharmacovigilance, de pharmaco-épidémiologie et d'information sur les médicaments, CHU de Limoges, 2, avenue Martin-Luther-King, 87042 Limoges cedex, France; Service de pharmacologie, toxicologie et pharmacovigilance, centre hospitalier universitaire, 87042 Limoges, France; Faculté de médecine, université de Limoges, 87042 Limoges, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Géniaux
authors.affiliation: Service de médecine gériatrique, pôle clinique médicale et gérontologie clinique, centre hospitalier universitaire, 87042 Limoges, France; EA6310, handicap activité, vieillissement, autonomie, environnement (HAVAE), université de Limoges, 87042 Limoges, France; Faculté de médecine, université de Limoges, 87042 Limoges, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Dantoine
authors.affiliation: EA6310, handicap activité, vieillissement, autonomie, environnement (HAVAE), université de Limoges, 87042 Limoges, France; Centre régional de pharmacovigilance, de pharmaco-épidémiologie et d'information sur les médicaments, CHU de Limoges, 2, avenue Martin-Luther-King, 87042 Limoges cedex, France; Service de pharmacologie, toxicologie et pharmacovigilance, centre hospitalier universitaire, 87042 Limoges, France; Faculté de médecine, université de Limoges, 87042 Limoges, France. Electronic address: marie-laure.laroche@chu-limoges.fr.
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Laroche
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions / Q000150:complications*; D016330:Frail Elderly; D006801:Humans; D057970:Inappropriate Prescribing / Q000009:adverse effects; D004364:Pharmaceutical Preparations
chemical_list: D004364:Pharmaceutical Preparations
keywords: Aged; Drug utilization; Drug-related side effects and adverse reactions; Effet indésirable médicamenteux; Fragilité; Frail elderly; Inappropriate prescribing; Personne âgée; Prescription inappropriée; Utilisation des médicaments