title: Use of Ceftolozane/Tazobactam in the Treatment of Multidrug-resistant Pseudomonas aeruginosa Bloodstream Infection in a Pediatric Leukemia Patient.
abstract: Multidrug-resistant Pseudomonas aeruginosa is of increasing concern in pediatric patients. Ceftolozane/tazobactam is a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant Pseudomonas; however, no data exist on its use in children. This report summarizes the treatment of a multidrug-resistant P. aeruginosa bloodstream infection in a pediatric leukemia patient with ceftolozane/tazobactam and provides the first description of its pharmacokinetics in pediatrics.
authors.affiliation: From the *Division of Pharmacy, †Department of Infectious Diseases, Infection Control, and Employee Health, ‡Department of Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas; §Center for Anti-infective Research and Development, Hartford Hospital, Hartford, Connecticut; and ¶Department of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Samuel L
authors.initials: SL
authors.lastname: Aitken
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Kontoyiannis
authors.forename: April M
authors.initials: AM
authors.lastname: DePombo
authors.forename: Micah M
authors.initials: MM
authors.lastname: Bhatti
authors.forename: Frank P
authors.initials: FP
authors.lastname: Tverdek
authors.forename: Suzanne C
authors.initials: SC
authors.lastname: Gettys
authors.forename: David P
authors.initials: DP
authors.lastname: Nicolau
authors.forename: Cesar A
authors.initials: CA
authors.lastname: Nunez
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000150:complications / Q000188:drug therapy*; D002511:Cephalosporins / Q000627:therapeutic use*; D002648:Child; D024901:Drug Resistance, Multiple, Bacterial; D006760:Hospitalization; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008297:Male; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000150:complications / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa; D000078142:Tazobactam
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C519491:ceftolozane; D010397:Penicillanic Acid; D000078142:Tazobactam