title: Cardiotoxicity in anthracycline therapy: Prevention strategies.
abstract: The increasing use of anthracyclines, together with the longer survival of cancer patients, means the toxic effects of these drugs need to be monitored. In order to detect, prevent or mitigate anthracycline-induced cardiomyopathy, it is essential that all patients undergo a rigorous initial cardiovascular assessment, followed by close monitoring. Several clinical trials have shown the cardioprotective effect of non-pharmacological measures such as exercise, healthy lifestyles, control of risk factors and treatment of comorbidities; a cardioprotective effect has also been observed with pharmacological measures such as beta-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists, statins, dexrazoxane and liposomal formulations. However, there are currently no guidelines for managing prevention in these patients. In this review the authors discuss the state of the art of the assessment, monitoring, and, above all, the prevention of anthracycline-induced cardiotoxicity.
authors.affiliation: Faculdade de Medicina, Universidade do Porto, Porto, Portugal.
authors.forename: Margarida
authors.initials: M
authors.lastname: Cruz
authors.affiliation: Serviço de Cardiologia, Hospital de S. João, Porto, Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Duarte-Rodrigues
authors.affiliation: Serviço de Cardiologia, Hospital de S. João, Porto, Portugal; Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS), Faculdade de Medicina, Universidade do Porto, Porto, Portugal. Electronic address: mcampelo@hotmail.com.
authors.forename: Manuel
authors.initials: M
authors.lastname: Campelo
mesh_terms: D018943:Anthracyclines / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D009202:Cardiomyopathies / Q000139:chemically induced; D066126:Cardiotoxicity / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D018943:Anthracyclines; D000970:Antineoplastic Agents
keywords: Anthracyclines; Antraciclinas; Cardiotoxicidade; Cardiotoxicity; Chemotherapy; Prevention; Prevenção; Quimioterapia