title: Hemodynamic Study of Flow Remodeling Stent Graft for the Treatment of Highly Angulated Abdominal Aortic Aneurysm.
abstract: This study investigates the effect of a novel flow remodeling stent graft (FRSG) on the hemodynamic characteristics in highly angulated abdominal aortic aneurysm based on computational fluid dynamics (CFD) approach. An idealized aortic aneurysm with varying aortic neck angulations was constructed and CFD simulations were performed on nonstented models and stented models with FRSG. The influence of FRSG intervention on the hemodynamic performance is analyzed and compared in terms of flow patterns, wall shear stress (WSS), and pressure distribution in the aneurysm. The findings showed that aortic neck angulations significantly influence the velocity flow field in nonstented models, with larger angulations shifting the mainstream blood flow towards the center of the aorta. By introducing FRSG treatment into the aneurysm, erratic flow recirculation pattern in the aneurysm sac diminishes while the average velocity magnitude in the aneurysm sac was reduced in the range of 39% to 53%. FRSG intervention protects the aneurysm against the impacts of high velocity concentrated flow and decreases wall shear stress by more than 50%. The simulation results highlighted that FRSG may effectively treat aneurysm with high aortic neck angulations via the mechanism of promoting thrombus formation and subsequently led to the resorption of the aneurysm.
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117575.
authors.forename: Siang Lin
authors.initials: SL
authors.lastname: Yeow
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117575.
authors.forename: Hwa Liang
authors.initials: HL
authors.lastname: Leo
mesh_terms: D000465:Algorithms; D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology* / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D003198:Computer Simulation; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D011312:Pressure; D033081:Shear Strength; D015607:Stents; D013314:Stress, Mechanical; D014783:Viscosity