title: Reply to Lesho and Clifford.
authors.affiliation: Center for Biostatistics in AIDS Research and the Department of Biostatistics, Harvard University, Boston, Massachusetts.
authors.forename: Scott
authors.initials: S
authors.lastname: Evans
authors.affiliation: Public Health Research Institute Center, New Jersey Medical School-Rutgers University, Newark.
authors.forename: Barry
authors.initials: B
authors.lastname: Kreiswirth
authors.affiliation: Duke Clinical Research Institute, Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
authors.forename: Vance
authors.initials: V
authors.lastname: Fowler
authors.affiliation: University of California, San Francisco General Hospital.
authors.forename: Henry
authors.initials: H
authors.lastname: Chambers
authors.affiliation: Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, and Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Robin
authors.initials: R
authors.lastname: Patel
authors.affiliation: Department of Medicine, Case Western Reserve University School of Medicine Louis Stokes Cleveland Department of Veterans Affairs Medical Center.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Hujer
authors.affiliation: Department of Medicine, Case Western Reserve University School of Medicine Louis Stokes Cleveland Department of Veterans Affairs Medical Center.
authors.forename: Federico
authors.initials: F
authors.lastname: Perez
authors.affiliation: Department of Medicine, Case Western Reserve University School of Medicine Louis Stokes Cleveland Department of Veterans Affairs Medical Center Departments of Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Bonomo