title: [Anti-hypertensive Effect of Total Flavonoids of Cydonia oblonga Leaves and Its Mechanism Based on Anti-inflammatory Function].
abstract: OBJECTIVE
  To study the anti-hypertensive effect of total flavonoids of Cydonia oblonga leaves in spontaneously hypertensive rats, then to preliminarily investigate the mechanism of action based on anti-inflammatory function.
  
  
  METHODS
  Spontaneously hypertensive rats were divided into six groups as spontaneously hypertensive control group (SHR), captopril group (25 mg/kg), Eucommia ulmoides group (30 mg/kg), total flavonoids of Cydonia oblonga leaves low (40 mg/kg), middle (80 mg/kg) and high dose (160 mg/kg) groups. Eight Wistar-Kyoto (WKY) rats were given distilled water as the control. The drugs were given by intragastric administration for 16 weeks, then the contents of IL-1β, IL-6, IL-10, TNF-α and CRP in rats serum were detected. The weight and the blood pressure of rats were measured at 0 min and 2, 4, 6, 8, 10, 12, 14, 16 weeks after drug administrated.
  
  
  RESULTS
  Compared with control group, the contents of IL-1β, IL-6, TNF-α and CRP were increased and IL-10 was decreased; Compared with SHR group, the contents of IL-1β,IL-6, TNF-α and CRP were decreased in total flavonoids of Cydonia oblonga leaves groups.
  
  
  CONCLUSIONS
  Total flavonoids of Cydonia oblonga leaves show an anti-hypertensive activity in spontaneously hypertensive rats and the mechanism is related to the function of anti-inflammatory.
authors.forename: Wen-ting
authors.initials: WT
authors.lastname: Zhou
authors.forename: Wu-li-ya
authors.initials: WL
authors.lastname: Yiming
authors.forename: Hu
authors.initials: H
authors.lastname: Ma
authors.forename: Guzalnur
authors.initials: G
authors.lastname: Mamat
authors.forename: Anwar
authors.initials: A
authors.lastname: Umar
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D002216:Captopril / Q000494:pharmacology; D016207:Cytokines / Q000097:blood; D031283:Eucommiaceae / Q000737:chemistry; D005419:Flavonoids / Q000494:pharmacology*; D006973:Hypertension / Q000188:drug therapy*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D027824:Rosaceae / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D016207:Cytokines; D005419:Flavonoids; D002097:C-Reactive Protein; D002216:Captopril