title: Spatial data aggregation for spatio-temporal individual-level models of infectious disease transmission.
abstract: A class of complex statistical models, known as individual-level models, have been effectively used to model the spread of infectious diseases. These models are often fitted within a Bayesian Markov chain Monte Carlo framework, which can have a sig nificant computational expense due to the complex nature of the likelihood function associated with this class of models. Increases in population size or duration of the modeled epidemic can contribute to this computational burden. Here, we explore the effect of reducing this computational expense by aggregating the data into spatial clusters, and therefore reducing the overall population size. Individual-level models, reparameterized to account for this aggregation effect, may then be fitted to the spatially aggregated data. The ability of two reparameterized individual-level models, when fitted to this reduced data set, to identify a covariate effect is investigated through a simulation study.
authors.affiliation: Department of Mathematics and Statistics, University of Guelph, Guelph, Ontario N1G 2W1, Canada. Electronic address: ldeeth@uoguelph.ca.
authors.forename: Lorna E
authors.initials: LE
authors.lastname: Deeth
authors.affiliation: Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada; Department of Mathematics and Statistics, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
authors.forename: Rob
authors.initials: R
authors.lastname: Deardon
mesh_terms: D003141:Communicable Diseases / Q000453:epidemiology* / Q000635:transmission; D003198:Computer Simulation / Q000706:statistics & numerical data; D003625:Data Collection / Q000706:statistics & numerical data*; D006801:Humans; D015233:Models, Statistical; D008962:Models, Theoretical; D062211:Spatio-Temporal Analysis
keywords: Disease modeling; Individual-level models; Spatial clustering