title: [THE CHOICE OF THE ANESTHESY OPTIMAL METHOD, USING DETERMINATION OF THE TOLL-LIKE RECEPTORS LEVEL IN THE PLASM AS A MARKER OF HYPERALGESIA IN EARLY POSTOPERATIVE PERIOD].
abstract: There were examined 47 children, operated on for tumors of abdominal cavity and retroperitoneal space. The opioid-induced hyperalgesia may occur in early postoperative period. The anesthesia conduction of m. transverses abdominis (TAP-block), using 0.375% bupivacaine solution and combined spinal epidural analgesia (CSEA) for postoperative anesthesia have promoted the hyperalgesia severity reduction. Hyperalgesia in early postoperative period was demonstrated by upgrading of the toll-like receptors (TLR-4) level in the blood. The TLR-4 expression increased in the blood was noted while application of a TAP-block and CSEA.
authors.forename: D V
authors.initials: DV
authors.lastname: Dmytriyev
mesh_terms: D000008:Abdominal Neoplasms / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D000701:Analgesics, Opioid / Q000009:adverse effects; D000767:Anesthesia, Epidural / Q000379:methods; D000775:Anesthesia, Spinal / Q000379:methods; D000779:Anesthetics, Local / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002045:Bupivacaine / Q000627:therapeutic use*; D002648:Child; D005260:Female; D015870:Gene Expression; D006801:Humans; D006930:Hyperalgesia / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis* / Q000517:prevention & control*; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D011184:Postoperative Period; D012186:Retroperitoneal Neoplasms / Q000473:pathology / Q000601:surgery; D051197:Toll-Like Receptor 4 / Q000097:blood* / Q000235:genetics
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D015415:Biomarkers; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D002045:Bupivacaine