title: Aberrant functional brain connectome in people with antisocial personality disorder.
abstract: Antisocial personality disorder (ASPD) is characterised by a disregard for social obligations and callous unconcern for the feelings of others. Studies have demonstrated that ASPD is associated with abnormalities in brain regions and aberrant functional connectivity. In this paper, topological organisation was examined in resting-state fMRI data obtained from 32 ASPD patients and 32 non-ASPD controls. The frequency-dependent functional networks were constructed using wavelet-based correlations over 90 brain regions. The topology of the functional networks of ASPD subjects was analysed via graph theoretical analysis. Furthermore, the abnormal functional connectivity was determined with a network-based statistic (NBS) approach. Our results revealed that, compared with the controls, the ASPD patients exhibited altered topological configuration of the functional connectome in the frequency interval of 0.016-0.031 Hz, as indicated by the increased clustering coefficient and decreased betweenness centrality in the medial superior frontal gyrus, precentral gyrus, Rolandic operculum, superior parietal gyrus, angular gyrus, and middle temporal pole. In addition, the ASPD patients showed increased functional connectivity mainly located in the default-mode network. The present study reveals an aberrant topological organisation of the functional brain network in individuals with ASPD. Our findings provide novel insight into the neuropathological mechanisms of ASPD.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China.|Biomedical Engineering Laboratory, School of Geosciences and Info-physics, Central South University, Changsha, Hunan 410083, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Tang
authors.affiliation: School of Information Science and Engineering, Central South University, Changsha, Hunan 410083, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Long
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liao
authors.affiliation: Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX 79409, USA.
authors.forename: Hua
authors.initials: H
authors.lastname: Xie
authors.affiliation: Biomedical Engineering Laboratory, School of Geosciences and Info-physics, Central South University, Changsha, Hunan 410083, China.
authors.forename: Guihu
authors.initials: G
authors.lastname: Zhao
authors.affiliation: Biomedical Engineering Laboratory, School of Geosciences and Info-physics, Central South University, Changsha, Hunan 410083, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000987:Antisocial Personality Disorder / Q000473:pathology*; D056808:Biostatistics; D001921:Brain / Q000473:pathology*; D063132:Connectome; D006801:Humans; D008279:Magnetic Resonance Imaging; D055815:Young Adult