title: Sex differences in age-related changes on peripheral warm and cold innocuous thermal sensitivity.
abstract: Cutaneous thermal sensitivity to a warm and cold stimulus was compared amongst 12 older (OF, 65.2±1.0year) and 29 younger (YF, 21.6±0.2years) female participants, and 17 older (OM, 66.2±1.5years) and 13 younger (YM, 21.2±0.4years) male participants to examine the effects of ageing and sex. In a neutral condition (27.5°C, 50% RH) during rest, warm and cold thermal sensitivity was measured on eight body regions (forehead, chest, back, forearm, hand, thigh, calf, and foot). Using the method of limits, a thermal stimulator was applied to the skin at an adapting temperature and either increased or decreased at a constant rate (0.3°C/s) until the participants detected the temperature with a push button. Thermal sensitivity declined with ageing to both a cold (older: 1468.6±744.7W/m(2), younger: 869.8±654.7W/m(2), p<0.001) and warm (older: 2127.0±1208.3W/m(2), younger: 1301.7±1055.2W/m(2), p<0.001) innocuous stimulus. YF and OF were more sensitive than YM and OM to both a warm and cold stimulus (p<0.05). There was no interaction between age and sex suggesting that whilst thermal sensitivity decreases with age the decrease is similar between the sexes (p>0.05). There was an interaction between temperatures, age and location and it seemed that cold thermal sensitivity was more homogenous for young and older participants however warm thermal sensitivity was more heterogeneous especially in the younger participants (p<0.05). Although the pattern was not similar between ages or sexes it was evident that the forehead was the most sensitive region to a warm and cold stimulus. Interestingly the decline in sensitivity observed with ageing occurred for all locations but was attenuated at the forehead in both males and females (p>0.05).
authors.affiliation: Laboratory for Human Performance Research, Osaka International University, Moriguchi, Osaka 570-8555, Japan. Electronic address: inoueyos@oiu.jp.
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Inoue
authors.affiliation: Institute of Sport and Exercise Science, University of Worcester, Henwick Road, Worcester, WR26AJ, United Kingdom; Laboratory for Applied Human Physiology, Graduate School of Human Development and Environment, Kobe University, Kobe 657-8501, Japan. Electronic address: N.Gerrett@icloud.com.
authors.forename: Nicola
authors.initials: N
authors.lastname: Gerrett
authors.affiliation: Laboratory for Human Performance Research, Osaka International University, Moriguchi, Osaka 570-8555, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ichinose-Kuwahara
authors.affiliation: Laboratory for Human Performance Research, Osaka International University, Moriguchi, Osaka 570-8555, Japan.
authors.forename: Yasue
authors.initials: Y
authors.lastname: Umino
authors.affiliation: Laboratory for Human Performance Research, Osaka International University, Moriguchi, Osaka 570-8555, Japan.
authors.forename: Saeko
authors.initials: S
authors.lastname: Kiuchi
authors.affiliation: Laboratory for Applied Human Physiology, Graduate School of Human Development and Environment, Kobe University, Kobe 657-8501, Japan. Electronic address: amano@ed.niigata-u.ac.jp.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Amano
authors.affiliation: Osaka Shin-ai College, Tsurumi-ku, Osaka 538-0053, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ueda
authors.affiliation: Environmental Ergonomics Research Centre, Loughborough Design School, Loughborough University, Loughborough LE113TU, United Kingdom. Electronic address: G.Havenith@lboro.ac.uk.
authors.forename: George
authors.initials: G
authors.lastname: Havenith
authors.affiliation: Laboratory for Applied Human Physiology, Graduate School of Human Development and Environment, Kobe University, Kobe 657-8501, Japan. Electronic address: kondo@kobe-u.ac.jp.
authors.forename: Narihiko
authors.initials: N
authors.lastname: Kondo
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D003080:Cold Temperature; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008875:Middle Aged; D010812:Physical Stimulation; D012727:Sex Characteristics; D012881:Skin Temperature; D013697:Thermosensing / Q000502:physiology*; D055815:Young Adult
keywords: Ageing; Regional differences; Sex; Temperature; Thermal sensitivity