title: [Effect of nano-SiO2 exposure on spatial learning and memory and LTP of hippocampal dentate gyrus in rats].
abstract: OBJECTIVE
  To study the effect of nano-SiO2 on spatial learning and memory.
  
  
  METHODS
  Twenty-four male rats were randomly divided into 3 groups: control group (C group), low dose group (L group) and high dose group (H group). The rats were intragastrically administrated with nanometer particles at 25 and 100 mg/kg body weight every day for 4 weeks. After exposure, the ability of learning and memory of rats was tested by Morris water maze, and electrophysiological brain stereotactic method was used to test long-tear potentiation (LTP) in dentate gyrus (DG) of the rats.
  
  
  RESULTS
  The increase rate of body weight in H group was reduced significantly compared with C group ( P < 0.05). In the space exploration experiment of Morris water maze test, the escape latency of H group was longer than that of C group (P < 0.05). The rats of H group spent less time in finding the target quadrant (P < 0.05) . The rate of LP induction of H group was significantly lower than that of C group (P < 0.05). After high fre quency stimulation (HFS), The changes of amplitude of population spike (PS) of L group and H group were lower than those of C group significantly (P < 0.05, P < 0.01).
  
  
  CONCLUSIONS
  Nano-SiO₂may result in impairment of spatial learning and memory ability by reducing the rate of LTP induction and the increase of PS in hippocampus.
authors.forename: Huan-rui
authors.initials: HR
authors.lastname: Sun
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.forename: Xue-wei
authors.initials: XW
authors.lastname: Chen
authors.forename: Gai-hong
authors.initials: GH
authors.lastname: An
authors.forename: Chuan-xiang
authors.initials: CX
authors.lastname: Xu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ma
mesh_terms: D000818:Animals; D018891:Dentate Gyrus / Q000187:drug effects*; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D053758:Nanoparticles / Q000009:adverse effects*; D051381:Rats; D012822:Silicon Dioxide / Q000009:adverse effects*; D065853:Spatial Learning / Q000187:drug effects*
chemical_list: D012822:Silicon Dioxide