title: Post-Translational Modifications and RNA-Binding Proteins.
abstract: RNA-binding proteins affect cellular metabolic programs through development and in response to cellular stimuli. Though much work has been done to elucidate the roles of a handful of RNA-binding proteins and their effect on RNA metabolism, the progress of studies to understand the effects of post-translational modifications of this class of proteins is far from complete. This chapter summarizes the work that has been done to identify the consequence of post-translational modifications to some RNA-binding proteins. The effects of these modifications have been shown to increase the panoply of functions that a given RNA-binding protein can assume. We will survey the experimental methods that are used to identify the presence of several protein modifications and methods that attempt to discern the consequence of these modifications.
authors.affiliation: Center for Molecular Biology and Genetic Engineering, University of Campinas, CBMEG-UNICAMP, Av Candido Rondon 400, Campinas, Sao Paulo, 13083-875, Brazil.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Lovci
authors.affiliation: Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, UNICAMP, Av Monteiro Lobato 255, Campinas, Sao Paulo, 13083-970, Brazil.
authors.forename: Mario H
authors.initials: MH
authors.lastname: Bengtson
authors.affiliation: Center for Molecular Biology and Genetic Engineering, University of Campinas, CBMEG-UNICAMP, Av Candido Rondon 400, Campinas, Sao Paulo, 13083-875, Brazil. kmassire@unicamp.brr.
authors.forename: Katlin B
authors.initials: KB
authors.lastname: Massirer
mesh_terms: D000818:Animals; D001692:Biological Transport; D003594:Cytoplasmic Granules / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D012313:RNA / Q000378:metabolism*; D012322:RNA Precursors / Q000378:metabolism; D012326:RNA Splicing; D020871:RNA Stability; D016601:RNA-Binding Proteins / Q000378:metabolism*; D013347:Subcellular Fractions / Q000378:metabolism; D058207:Sumoylation; D014158:Transcription, Genetic; D054875:Ubiquitination
chemical_list: D035683:MicroRNAs; D012322:RNA Precursors; D016601:RNA-Binding Proteins; D012313:RNA
keywords: Phosphorylation; Post-translational modifications; RNA-binding proteins; SUMOylation; Ubiquitination