title: Concurrent Post-Transplantation Diabetes Mellitus in Renal Allograft Recipients With Immunoglobulin A Nephropathy.
abstract: BACKGROUND
  The prevalence of post-transplantation immunoglobulin A nephropathy (PTIgAN) and diabetes mellitus (PTDM) increases with time after transplantation, and recognition and management of these conditions is becoming more important in renal allograft recipients as graft survival increases.
  
  
  METHODS
  We explored the influence of concurrent PTDM on renal allograft histology and function in 111 cases with PTIgAN diagnosed from 2000 to 2010 at our institution.
  
  
  RESULTS
  Sixteen patients (14.4%) had PTDM at the time of diagnosis of PTIgAN, which increased to 28 patients (25.2%) at the last follow-up (10.4 years after transplantation). Donor ages were younger in PTIgAN patients with concurrent PTDM. However, other clinical and demographic data were not significantly different between PTIgAN patients with and without PTDM. Histologically, Banff "mm" scores were higher and "M1" of the Oxford classification was more frequent in PTIgAN patients with concurrent PTDM than in patients without PTDM, but the difference did not reach statistical significance. Serum creatinine levels and proteinuria at the time of biopsy and overall graft survival did not vary according to the presence of PTDM both at biopsy and at the last follow-up.
  
  
  CONCLUSIONS
  Concurrent PTDM does not significantly influence graft function or outcome for 10 years after transplantation in PTIgAN patients.
authors.affiliation: Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: H S
authors.initials: HS
authors.lastname: Jeong
authors.affiliation: Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: B J
authors.initials: BJ
authors.lastname: Lim
authors.affiliation: Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: H J
authors.initials: HJ
authors.lastname: Kwon
authors.affiliation: Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea; Institute of Transplantation, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: B S
authors.initials: BS
authors.lastname: Kim
authors.affiliation: Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea; Institute of Transplantation, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Huh
authors.affiliation: Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea; Institute of Transplantation, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: S I
authors.initials: SI
authors.lastname: Kim
authors.affiliation: Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea; Institute of Transplantation, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: M S
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Pathology, Yonsei University College of Medicine, Seoul, Korea; Institute of Transplantation, Yonsei University College of Medicine, Seoul, Korea. Electronic address: jeong10@yuhs.ac.
authors.forename: H J
authors.initials: HJ
authors.lastname: Jeong
mesh_terms: D000328:Adult; D001706:Biopsy; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000648:ultrastructure; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008854:Microscopy, Electron; D011183:Postoperative Complications; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D014184:Transplantation, Homologous
chemical_list: D001786:Blood Glucose