title: Initial experience with ocriplasmin in the treatment of vitreomacular traction.
abstract: This study aimed to report the clinical and structural outcomes of intravitreal ocriplasmin in the treatment of vitreomacular interface disorders in two tertiary centers in Brazil. A retrospective study was performed by reviewing medical records and spectral domain optical coherence tomography (SD-OCT) findings of seven patients who were treated with a single ocriplasmin injection. A total of 57.14% of patients achieved resolution of vitreomacular traction as evidenced by SD-OCT. Regarding our functional results, 87.71% maintained or improved visual acuity after follow-up. To the best of our knowledge, this is the first study reporting initial results of ocriplasmin therapy in Brazil.
authors.affiliation: Ophthalmology Department, Centro de Referência em Oftalmologia, Goiânia, GO, Brazil.
authors.forename: José Maurício Botto de Barros
authors.initials: JM
authors.lastname: Garcia
authors.affiliation: Ophthalmology Department, Centro de Referência em Oftalmologia, Goiânia, GO, Brazil.
authors.forename: David Leonardo Cruvinel
authors.initials: DL
authors.lastname: Isaac
authors.affiliation: Ophthalmology Department, Centro de Referência em Oftalmologia, Goiânia, GO, Brazil.
authors.forename: Marcos
authors.initials: M
authors.lastname: Ávila
mesh_terms: D000368:Aged; D001938:Brazil; D005260:Female; D005341:Fibrinolysin / Q000008:administration & dosage / Q000627:therapeutic use*; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D000267:Tissue Adhesions / Q000188:drug therapy; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity / Q000187:drug effects; D014822:Vitreous Body / Q000187:drug effects / Q000473:pathology; D020255:Vitreous Detachment / Q000188:drug therapy* / Q000473:pathology
chemical_list: D005343:Fibrinolytic Agents; D010446:Peptide Fragments; C054561:microplasmin; D005341:Fibrinolysin