title: Asymmetric dual catalysis via fragmentation of a single rhodium precursor complex.
abstract: A strategy for dual transition metal catalysis and organocatalysis is reported via the in situ disintegration of a single rhodium complex. The hereby generated chiral Lewis acid and l-β-phenylalanine synergistically catalyze the Michael addition of α,α-disubstituted aldehydes to α,β-unsaturated 2-acyl imidazoles under the formation of vicinal quaternary/tertiary stereocenters. Conveniently, the chiral-at-metal rhodium catalyst can be synthesized in just two steps starting from rhodium trichloride without the need for any chromatography.
authors.affiliation: College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People's Republic of China. gongl@xmu.edu.cn meggers@chemie.uni-marburg.de.
authors.forename: Liangliang
authors.initials: L
authors.lastname: Song
authors.affiliation: College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People's Republic of China. gongl@xmu.edu.cn meggers@chemie.uni-marburg.de.
authors.forename: Lei
authors.initials: L
authors.lastname: Gong
authors.affiliation: College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People's Republic of China. gongl@xmu.edu.cn meggers@chemie.uni-marburg.de and Philipps-Universität Marburg, Hans-Meerwein-Strasse 4, 35043 Marburg, Germany.
authors.forename: Eric
authors.initials: E
authors.lastname: Meggers