title: E-Cadherin, CD44v6, and Insulin-Like Growth Factor-II mRNA-Binding Protein 3 Expressions in Different Stages of Hydatidiform Moles.
abstract: E-cadherin, CD44v6, and IMP3 expression in partial, complete, and invasive hydatidiform moles (HMs) was evaluated. High E-cadherin expression with low CD44v6 expression was observed in partial, complete, and invasive HMs, as well as in normal placental tissues; and there was no significant difference in E-cadherin and CD44v6 expression among the four groups. However, IMP3 expression was gradually decreased in the order of normal placental tissues, partial HMs, complete HMs, and invasive HMs; wherein, invasive HMs had the lowest level. Low IMP3 expression may serve as a prognostic biomarker for HMs, and IMP3 may play a certain role in HMs progression.
authors.affiliation: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou, People's Republic of China.
authors.forename: Jiajun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Gynecology, The Affiliated Maternity and Child Health Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, 214002, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Prenatal Diagnosis Center, The Affiliated Maternity and Child Health Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, 214002, People's Republic of China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Department of Gynecology, The Affiliated Maternity and Child Health Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, 214002, People's Republic of China.
authors.forename: Man
authors.initials: M
authors.lastname: Wu
authors.affiliation: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou, People's Republic of China. yaohua_song1@yahoo.com.
authors.forename: Yaohua
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Pathology, The Affiliated Maternity and Child Health Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, 214002, People's Republic of China. yinyongxiang0118@outlook.com.
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Yin
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D015820:Cadherins / Q000235:genetics* / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D005786:Gene Expression Regulation; D005865:Gestational Age; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics* / Q000378:metabolism; D006828:Hydatidiform Mole / Q000145:classification / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism / Q000473:pathology; D014592:Uterine Hemorrhage / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology
chemical_list: D015415:Biomarkers; C112697:CD44v6 antigen; D015820:Cadherins; D018960:Hyaluronan Receptors; C498780:IGF2BP3 protein, human; D012333:RNA, Messenger; D016601:RNA-Binding Proteins
keywords: CD44v6; E-Cadherin; Hydatidiform Mole; IMP3