title: Interactions between Pseudomonas aeruginosa and Staphylococcus aureus during co-cultivations and polymicrobial infections.
abstract: Pseudomonas aeruginosa and Staphylococcus aureus are versatile bacterial pathogens and common etiological agents in polymicrobial infections. Microbial communities containing both of these pathogens are shaped by interactions ranging from parasitic to mutualistic, with the net impact of these interactions in many cases resulting in enhanced virulence. Polymicrobial communities of these organisms are further defined by multiple aspects of the host environment, with important implications for disease progression and therapeutic outcomes. This mini-review highlights the impact of these interactions on the host and individual pathogens, the molecular mechanisms that underlie these interactions, and host-specific factors that drive interactions between these two important pathogens.
authors.affiliation: School of Pharmacy, Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD, 21201, USA.
authors.forename: Angela T
authors.initials: AT
authors.lastname: Nguyen
authors.affiliation: School of Pharmacy, Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD, 21201, USA. aoglesby@rx.umaryland.edu.|School of Medicine, Department of Microbiology and Immunology, University of Maryland, Baltimore, MD, 21201, USA. aoglesby@rx.umaryland.edu.
authors.forename: Amanda G
authors.initials: AG
authors.lastname: Oglesby-Sherrouse
mesh_terms: D018920:Coculture Techniques; D060085:Coinfection / Q000276:immunology / Q000382:microbiology*; D003550:Cystic Fibrosis / Q000276:immunology / Q000382:microbiology; D018450:Disease Progression; D054884:Host-Pathogen Interactions; D006801:Humans; D007109:Immunity; D007501:Iron / Q000097:blood; D056265:Microbial Interactions / Q000502:physiology*; D011550:Pseudomonas aeruginosa / Q000502:physiology*; D013211:Staphylococcus aureus / Q000502:physiology*
chemical_list: D007501:Iron
keywords: Alkyl-quinolones; Cystic fibrosis; Polymicrobial infections; Pseudomonas aeruginosa; Staphylococcus aureus