title: [Psychopharmacotherapy for depression in rheumatic patients].
abstract: OBJECTIVE
  To study attitude towards the disease in rheumatic patients during antidepressant therapy and during further follow-up.
  
  
  METHODS
  Examinations were made in 122 patients with degenerative joint and vertebral column disease (DJVCD) and in 30 patients with rheumatoid arthritis (RA) and concomitant affective disorders during antidepressant therapy for 3 months.
  
  
  RESULTS
  Statistically significant differences were found between all components of the type of attitude towards disease (TATD) in patients with DJVCD or RA before the use of antidepressants. In the patients with RA, the mean value of adaptive types of TATD was significantly lower and that of disadaptive types significantly higher. After 3 months of treatment, the TATD profiles came closer. Only three components (anosognosia, hypochondriasis, and dysphoria) in the pattern of TATD remained significantly different after 6-month therapy.
  
  
  CONCLUSIONS
  According to the TATD data, both the patients with DJVCD and those with inflammatory diseases of the locomotor apparatus showed unidirectional changes in attitude towards disease with a significant increase in the adaptive components and a reduction in the disadaptive ones.
authors.affiliation: Yaroslavl State Medical University, Ministry of Health of Russia, Yaroslavl, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Yaltzeva
authors.affiliation: Yaroslavl State Medical University, Ministry of Health of Russia, Yaroslavl, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Korshunov
authors.affiliation: Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia, Moscow, Russia.
authors.forename: M I
authors.initials: MI
authors.lastname: Savelyeva
authors.affiliation: Yaroslavl State Medical University, Ministry of Health of Russia, Yaroslavl, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Politova
authors.affiliation: Yaroslavl State Medical University, Ministry of Health of Russia, Yaroslavl, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Khaerova
authors.affiliation: Yaroslavl State Medical University, Ministry of Health of Russia, Yaroslavl, Russia.
authors.forename: Е А
authors.initials: ЕА
authors.lastname: Leontyeva
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000494:pharmacology*; D001172:Arthritis, Rheumatoid / Q000523:psychology*; D001294:Attitude to Health; D003863:Depression / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000523:psychology*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents