title: Blood Selenium Concentration and Blood Cystatin C Concentration in a Randomly Selected Population of Healthy Children Environmentally Exposed to Lead and Cadmium.
abstract: This study aimed at evaluation of a relationship between blood selenium concentration (Se-B) and blood cystatin C concentration (CST) in a randomly selected population of healthy children, environmentally exposed to lead and cadmium. The studies were conducted on 172 randomly selected children (7.98 ± 0.97 years). Among participants, the subgroups were distinguished, manifesting marginally low blood selenium concentration (Se-B 40-59 μg/l), suboptimal blood selenium concentration (Se-B: 60-79 μg/l) or optimal blood selenium concentration (Se-B ≥ 80 μg/l). At the subsequent stage, analogous subgroups of participants were selected separately in groups of children with BMI below median value (BMI <16.48 kg/m2) and in children with BMI ≥ median value (BMI ≥16.48 kg/m2). In all participants, values of Se-B and CST were estimated. In the entire group of examined children no significant differences in mean CST values were detected between groups distinguished on the base of normative Se-B values. Among children with BMI below 16.48 kg/m2, children with marginally low Se-B manifested significantly higher mean CST values, as compared to children with optimum Se-B (0.95 ± 0.07 vs. 0.82 ± 0.15 mg/l, p < 0.05). In summary, in a randomly selected population of healthy children no relationships could be detected between blood selenium concentration and blood cystatin C concentration. On the other hand, in children with low body mass index, a negative non-linear relationship was present between blood selenium concentration and blood cystatin C concentration.
authors.affiliation: Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, 50-368, Wrocław, Poland. pawelgac@interia.pl.
authors.forename: Paweł
authors.initials: P
authors.lastname: Gać
authors.affiliation: Institute of Occupational Medicine and Environmental Health in Sosnowiec, Kościelna 13, 41-200, Sosnowiec, Poland.
authors.forename: Natalia
authors.initials: N
authors.lastname: Pawlas
authors.affiliation: Institute of Occupational Medicine and Environmental Health in Sosnowiec, Kościelna 13, 41-200, Sosnowiec, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Wylężek
authors.affiliation: Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, 50-556, Wrocław, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Poręba
authors.affiliation: Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1, 50-368, Wrocław, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Poręba
authors.affiliation: Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, 50-368, Wrocław, Poland.|Institute of Occupational Medicine and Environmental Health in Sosnowiec, Kościelna 13, 41-200, Sosnowiec, Poland.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Pawlas
mesh_terms: D002104:Cadmium / Q000633:toxicity*; D002648:Child; D002675:Child, Preschool; D055316:Cystatin C / Q000097:blood*; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007854:Lead / Q000633:toxicity*; D008297:Male; D012643:Selenium / Q000097:blood*
chemical_list: C525030:CST3 protein, human; D055316:Cystatin C; D002104:Cadmium; D007854:Lead; D012643:Selenium
keywords: Blood cystatin C concentration; Blood selenium concentration; Cadmium; Children; Lead