title: Lipid- and Polymer-Based Nanostructures for Cutaneous Delivery of Curcumin.
abstract: It is well-known that nanoencapsulation may overcome biopharmaceutical limitations of curcumin (CUR), but studies regarding the contribution of the vesicular nature of CUR-loaded nanoparticles on skin permeation are still scarce. Therefore, the effect of three colloidal systems (solid lipid nanoparticles (SLN), nanoemulsion (NE), and polymeric nanoparticles (NP)) on the control of cutaneous permeation of CUR was investigated in porcine ear skin/Franz diffusion cells. Colloidal suspensions were designed to present a similar particle size (±170 nm), narrow size distribution (PdI < 0.2), and high entrapment efficiency (>99%). Zeta potential values were -0.13, -9.68 and -36.7 mV for the CUR-loaded NP, SLN and NE, respectively. Nanoencapsulation resulted in a cumulative amount of CUR in the more superficial layers of the skin. NP significantly enhanced the compound retention in the epidermis, which was approximately 2.49- and 3.32-fold more than SLN and NE, respectively. The CUR levels into the dermis were significantly increased after treatment with NE, which may be associated with repulsion phenomena in surface skin. Therefore, a more superficial or deeper action of CUR on the skin may be obtained depending on nanostructure type. While NPs are more effective in upper skin layers, NE should be prioritized when a dermal action for the CUR is required.
authors.affiliation: Laboratório de Controle de Qualidade, Programa de Pós-Graduação em Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina (UFSC), Campus Universitário, Trindade, 88040-900, Florianópolis, SC, Brazil. thiagocaon@gmail.com.|Laboratório de Farmacotécnica e Cosmetologia, Programa de Pós-Graduação em Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina (UFSC), Campus Universitário, Trindade, 88040-900, Florianópolis, SC, Brazil. thiagocaon@gmail.com.
authors.forename: Thiago
authors.initials: T
authors.lastname: Caon
authors.affiliation: Laboratório de Controle de Qualidade, Programa de Pós-Graduação em Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina (UFSC), Campus Universitário, Trindade, 88040-900, Florianópolis, SC, Brazil.
authors.forename: Letícia
authors.initials: L
authors.lastname: Mazzarino
authors.affiliation: Laboratório de Virologia Aplicada, Programa de Pós-Graduação em Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina (UFSC), Campus Universitário, Trindade, 88040-900, Florianópolis, SC, Brazil.
authors.forename: Cláudia Maria Oliveira
authors.initials: CM
authors.lastname: Simões
authors.affiliation: Laboratório de Farmacotécnica e Cosmetologia, Programa de Pós-Graduação em Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina (UFSC), Campus Universitário, Trindade, 88040-900, Florianópolis, SC, Brazil.
authors.forename: Elenara Lemos
authors.initials: EL
authors.lastname: Senna
authors.affiliation: Laboratório de Controle de Qualidade, Programa de Pós-Graduação em Farmácia, Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina (UFSC), Campus Universitário, Trindade, 88040-900, Florianópolis, SC, Brazil.
authors.forename: Marcos Antônio Segatto
authors.initials: MA
authors.lastname: Silva
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D003474:Curcumin / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D004655:Emulsions / Q000008:administration & dosage / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D010539:Permeability; D011108:Polymers / Q000737:chemistry*; D012867:Skin / Q000378:metabolism*; D013552:Swine
chemical_list: D004655:Emulsions; D008055:Lipids; D011108:Polymers; D003474:Curcumin
keywords: curcumin; nanoemulsions; polymeric nanoparticle; skin permeation; solid lipid nanoparticle