title: Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial.
abstract: To determine whether moderate-intensity physical activity (PA) and health education (HE) are differentially associated with categories of hospitalizations or subgroups of participants.
  
  
  
  Multicenter randomized controlled trial in which participants were randomized to a PA or HE program for an average of 2.6 years.
  
  
  
  Eight field centers.
  
  
  
  Sedentary men and women aged 70-89 with lower extremity physical limitations but able to walk 400-m in 15 minutes or less (N = 1,635).
  
  
  
  Structured, moderate-intensity PA (n =  818) at a center (2×/wk) and at home (3-4×/wk) that included aerobic, strength, balance, and flexibility training or HE (n =  817) of educational workshops and upper extremity stretching exercises.
  
  
  
  All-cause inpatient hospitalizations ascertained at 6-month intervals.
  
  
  
  There were 1,458 hospitalizations (49.1% of PA, 44.4% of HE; risk difference = 4.68%, 95% confidence interval (CI) = -0.18-9.54; hazard ratio (HR) = 1.16, 95% CI = 1.00-1.34). The intervention effect on incident hospitalization did not differ according to race, sex, Short Physical Performance Battery score, age, or history of cardiovascular disease or diabetes mellitus. PA was associated with higher rates of hospitalization in the middle baseline gait speed category, than HE (<0.8 m/s: HR = 0.93, 95% CI = 0.76-1.14; 0.8-1.0 m/s: HR = 1.54, 95% CI = 1.23-1.94; >1.0 m/s: HR = 1.05, 95% CI = 0.67-1.65; interaction P = .005).
  
  
  
  A PA program in older adults at risk for mobility disability did not lead to a different risk of specific types of hospitalizations than a HE program overall. Baseline gait speed may be a marker for risk of hospitalization during a PA intervention, because individuals with moderate baseline gait speed in the PA group had slightly higher rates of hospitalization than those in the HE group.
  
  
  
  ClinicalTrials.gov identifier: NCT01072500.
authors.affiliation: Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Marsh
authors.affiliation: Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Sticht Center on Aging, Wake Forest University, Winston-Salem, North Carolina.
authors.forename: William B
authors.initials: WB
authors.lastname: Applegate
authors.affiliation: Division of Gerontology, Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, Maryland.
authors.forename: Jack M
authors.initials: JM
authors.lastname: Guralnik
authors.affiliation: Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina.
authors.forename: W
authors.initials: W
authors.lastname: Jack Rejeski
authors.affiliation: Division of Gerontology, Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, Maryland.
authors.forename: Timothy S
authors.initials: TS
authors.lastname: Church
authors.affiliation: Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.
authors.forename: Roger A
authors.initials: RA
authors.lastname: Fielding
authors.affiliation: Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Gill
authors.affiliation: Department of Health Research and Policy, School of Medicine, Stanford University, Stanford, California.|Department of Medicine, School of Medicine, Stanford University, Stanford, California.
authors.forename: Abby C
authors.initials: AC
authors.lastname: King
authors.affiliation: Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Sticht Center on Aging, Wake Forest University, Winston-Salem, North Carolina.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Kritchevsky
authors.affiliation: Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida.|Department of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Manini
authors.affiliation: Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida.|Department of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
authors.forename: Mary M
authors.initials: MM
authors.lastname: McDermott
authors.affiliation: Department of Epidemiology and Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Anne B
authors.initials: AB
authors.lastname: Newman
authors.affiliation: Division of Public Health Sciences, Department of Biostatistical Sciences, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Stowe
authors.affiliation: Division of Public Health Sciences, Department of Biostatistical Sciences, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Walkup
authors.affiliation: Department of Aging and Geriatric Research, Institute on Aging, College of Medicine, University of Florida, Gainesville, Florida.|Department of Medicine and Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
authors.forename: Marco
authors.initials: M
authors.lastname: Pahor
authors.affiliation: Division of Public Health Sciences, Department of Biostatistical Sciences, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Miller
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006233:Persons with Disabilities / Q000534:rehabilitation*; D005081:Exercise Therapy; D005260:Female; D015577:Geriatric Assessment; D006266:Health Education; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008019:Life Style; D008297:Male; D051346:Mobility Limitation; D012307:Risk Factors; D057185:Sedentary Behavior; D016037:Single-Blind Method
keywords: hospitalizations; mobility disability; older adults; physical activity; safety