title: Genetic Variation in the TAS2R38 Bitter Taste Receptor and Gastric Cancer Risk in Koreans.
abstract: The human TAS2R38 gene encodes a bitter taste receptor that regulates the bitterness perception and differentiation of ingested nutritional/poisonous compounds in the oral cavity and gastrointestinal tract. TAS2R38 gene variants are associated with alterations in individual sensitivity to bitter taste and food intake; hence, these genetic variants may modify the risk for diet-related diseases, including cancer. However, little is known about the association between TAS2R38 polymorphisms and gastric cancer susceptibility. The present case-control study examined the influence of TAS2R38 polymorphisms on food intake and determined whether they predict gastric cancer risk in Koreans. A total of 1,580 subjects, including 449 gastric cancer cases, were genotyped for TAS2R38 A49P, V262A, I296V and diplotypes. Dietary data were analysed to determine the total consumption of energy, fibre, vegetables, fruits, sweets, fats, alcohol and cigarettes. TAS2R38 diplotype was not associated with food, alcohol or cigarette consumption, either independent or dependent of gastric cancer phenotype. However, the PAV/AVI diplotype significantly increased gastric cancer risk (adjusted odds ratio: 1.513; 95% confidence interval: 1.148-1.994) independent of dietary intake. Findings suggest that TAS2R38 may be associated with the risk for gastric cancer in Koreans, although the TAS2R38 diplotype did not influence dietary intake.
authors.affiliation: Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention,National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si,Gyonggi-do,410-769,Korea.
authors.forename: Jeong-Hwa
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention,National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si,Gyonggi-do,410-769,Korea.
authors.forename: Jeonghee
authors.initials: J
authors.lastname: Lee
authors.affiliation: Center for Gastric Cancer, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyonggi-do, 410-769, Korea.
authors.forename: Il Ju
authors.initials: IJ
authors.lastname: Choi
authors.affiliation: Center for Gastric Cancer, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyonggi-do, 410-769, Korea.
authors.forename: Young-Woo
authors.initials: YW
authors.lastname: Kim
authors.affiliation: Center for Gastric Cancer, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyonggi-do, 410-769, Korea.
authors.forename: Keun Won
authors.initials: KW
authors.lastname: Ryu
authors.affiliation: Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention,National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si,Gyonggi-do,410-769,Korea.
authors.forename: Jeongseon
authors.initials: J
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000503:physiopathology; D044466:Asian People; D000075528:Aversive Agents / Q000737:chemistry / Q000378:metabolism; D016022:Case-Control Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage; D004435:Eating / Q000502:physiology; D005260:Female; D005638:Fruit / Q000737:chemistry; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism; D012306:Risk; D012907:Smoking / Q000503:physiopathology; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D013649:Taste / Q000235:genetics*; D014675:Vegetables / Q000737:chemistry; D000098706:Taste Receptors, Type 2
chemical_list: D000075528:Aversive Agents; D004040:Dietary Carbohydrates; D004043:Dietary Fiber; D043562:Receptors, G-Protein-Coupled; D000098706:Taste Receptors, Type 2