title: Outstanding Antibiofilm Features of Quanta-CuO Film on Glass Surface.
abstract: Intelligently designed surface nanoarchitecture provides defined control over the behavior of cells and biomolecules at the solid-liquid interface. In this study, CuO quantum dots (quanta-CuO; ∼3-5 nm) were synthesized by a simple, low-temperature solution process and further formulated as paint to construct quanta-CuO thin film on glass. Surface morphological characterizations of the as-coated glass surface reveal a uniform film thickness (∼120 ± 10 nm) with homogeneous distribution of quanta-CuO. The antibiofilm assay showed a very high contact bacteria-killing capacity of as-coated quanta-CuO glass surfaces toward Staphylococcus aureus and Escherichia coli. This efficient antibacterial/antibiofilm activity was ascribed to the intracellular reactive oxygen species (ROS) generated by the quanta-CuO attached to the bacterial cells, which leads to an oxidative assault and finally results in bacterial cell death. Although there is a significant debate regarding the CuO nanostructure's antibacterial mode of action, we propose both contact killing and/or copper ion release killing mechanisms for the antibiofilm activity of quanta-CuO paint. Moreover, synergism of quanta-CuO with conventional antibiotics was also found to further enhance the antibacterial efficacy of commonly used antibiotics. Collectively, this state-of-the-art design of quanta-CuO coated glass can be envisioned as promising candidates for various biomedical and environmental device coatings.
authors.affiliation: Department of BIN Fusion Technology, Department of PolymerNano Science, and Polymer BIN Research Center, Chonbuk National University , 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Republic of Korea.
authors.forename: Nirmalya
authors.initials: N
authors.lastname: Tripathy
authors.affiliation: School of Semiconductor and Chemical Engineering, Nanomaterials Processing Research, Chonbuk National University , 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Republic of Korea.
authors.forename: Rafiq
authors.initials: R
authors.lastname: Ahmad
authors.affiliation: Department of Bioprocess Engineering, Chonbuk National University , 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Republic of Korea.
authors.forename: Seung Hyuck
authors.initials: SH
authors.lastname: Bang
authors.affiliation: Department of BIN Fusion Technology, Department of PolymerNano Science, and Polymer BIN Research Center, Chonbuk National University , 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Republic of Korea.
authors.forename: Gilson
authors.initials: G
authors.lastname: Khang
authors.affiliation: Department of Bioprocess Engineering, Chonbuk National University , 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Republic of Korea.|Department of Chemical Engineering, Chonbuk National University , 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54896 Republic of Korea.
authors.forename: Jiho
authors.initials: J
authors.lastname: Min
authors.affiliation: School of Semiconductor and Chemical Engineering, Nanomaterials Processing Research, Chonbuk National University , 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896, Republic of Korea.
authors.forename: Yoon-Bong
authors.initials: YB
authors.lastname: Hahn
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D003300:Copper / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D005898:Glass / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D003300:Copper; C030973:cupric oxide
keywords: antibacterial; antibiofilm; antibiotics; film; glass; quanta-CuO