title: Metabolic Crosstalk between Leishmania and the Macrophage Host.
abstract: Goldman-Pinkovich et al. have shown that intracellular stages of Leishmania actively sense arginine levels within the phagolysosome of the host macrophage and activate a MAP kinase-dependent response when arginine is reduced. This response may impact macrophages responses as well as being required for parasite intracellular replication.
authors.affiliation: Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, VIC 3010, Australia. Electronic address: malcolmm@unimelb.edu.au.
authors.forename: Malcolm J
authors.initials: MJ
authors.lastname: McConville
mesh_terms: D000818:Animals; D006790:Host-Parasite Interactions / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007891:Leishmania / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism / Q000469:parasitology*