title: Clinicopathologic Similarities of the Main and Minor Lesions of Synchronous Multiple Early Gastric Cancer.
abstract: The detection rate of early gastric cancer (EGC) is increasing due to improvements in diagnostic methods, but synchronous multiple EGC (SMEGC) remains a major problem. Therefore, we investigated the characteristics of and the correlation between the main and minor lesions of SMEGC. We retrospectively reviewed the medical records of patients with EGC between April 2008 and May 2013. The main lesion was defined as the one with the greatest invasion depth. If lesions had the same invasion depth, the tumor diameter was used to define the main lesion. Of 963 patients who had treatment for EGC, 37 patients with SMEGC were analyzed. The main and minor lesions showed a significant positive correlation of size (r = 0.533, P = 0.001). The main and minor lesions of SMEGC showed the same vertical and horizontal locations at 70.3% and 64.9%, respectively (P = 0.002 and P = 0.002). Macroscopic types were identical in 67.6% (P < 0.001), and 32.4% had identical macroscopic type and location. The main and minor lesions had identical characteristics of invasion depth, presence of lymphovascular invasion (LVI), and differentiation in 78.4%, 83.8%, and 83.8%, respectively. Differentiation, LVI, and invasion depth (microscopic characteristics) were simultaneously the same in 62.2%. The location, macroscopic type, and 3 microscopic characteristics were matched in 27%. The main and minor lesions of SMEGC have similar clinicopathologic characteristics. Therefore, the possibility of SMEGC should not be neglected in cases of EGC, considering an understanding of the characteristics and association of lesions.
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.; Depatment of Internal Medicine, School of Medicine, Gachon University, Incheon, Korea.; Gachon Medical Research Institute, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Jung Ho
authors.identifier: 0000-0002-6944-473X
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea .
authors.forename: Seok Hoo
authors.identifier: 0000-0001-9197-1184
authors.initials: SH
authors.lastname: Jeong
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea .
authors.forename: Jina
authors.identifier: 0000-0002-7923-8729
authors.initials: J
authors.lastname: Yeo
authors.affiliation: Department of Surgery, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Korea .
authors.forename: Woon Kee
authors.identifier: 0000-0001-9494-4026
authors.initials: WK
authors.lastname: Lee
authors.affiliation: Department of Pathology, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Korea .
authors.forename: Dong Hae
authors.identifier: 0000-0002-4538-0989
authors.initials: DH
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.; Depatment of Internal Medicine, School of Medicine, Gachon University, Incheon, Korea.
authors.forename: Kyoung Oh
authors.identifier: 0000-0002-5365-2550
authors.initials: KO
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.; Depatment of Internal Medicine, School of Medicine, Gachon University, Incheon, Korea.
authors.forename: Jun-Won
authors.identifier: 0000-0002-0869-7661
authors.initials: JW
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.; Depatment of Internal Medicine, School of Medicine, Gachon University, Incheon, Korea.; Gachon Medical Research Institute, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Yoon Jae
authors.identifier: 0000-0001-8477-6823
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.; Depatment of Internal Medicine, School of Medicine, Gachon University, Incheon, Korea.; Gachon Medical Research Institute, Gachon University Gil Medical Center, Incheon, Korea.
authors.forename: Kwang An
authors.identifier: 0000-0002-2947-2111
authors.initials: KA
authors.lastname: Kwon
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.; Depatment of Internal Medicine, School of Medicine, Gachon University, Incheon, Korea.
authors.forename: Dong Kyun
authors.identifier: 0000-0002-2862-6641
authors.initials: DK
authors.lastname: Park
mesh_terms: D000368:Aged; D055088:Early Detection of Cancer; D005260:Female; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology*
keywords: Endoscopy; Gastrectomy; Neoplasms, Multiple Primary, Synchronous; Stomach