title: Brief Report: HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β.
abstract: HIV infection is marked by phenotypic and functional alterations of immune cells. Different studies have shown both numerical and functional deterioration of dendritic cells in HIV-1-infected patients. In this study, we report an increase of inflammatory 6-sulfo LacNAc dendritic cells (slanDCs) that are more activated and produce higher amounts of interleukin (IL)-1β during HIV-1 infection as compared with healthy controls. IL-1β plays a regulatory role in chronic inflammatory disorders. Therefore, our findings might reveal a compensatory regulatory function of slanDCs during HIV-1 infection.
authors.affiliation: Department of Clinical Immunology and Rheumatology, Hannover Medical School (MHH), Hannover, Germany.
authors.forename: Dejene M
authors.initials: DM
authors.lastname: Tufa
authors.forename: Fareed
authors.initials: F
authors.lastname: Ahmad
authors.forename: Debanjana
authors.initials: D
authors.lastname: Chatterjee
authors.forename: Gerrit
authors.initials: G
authors.lastname: Ahrenstorf
authors.forename: Reinhold E
authors.initials: RE
authors.lastname: Schmidt
authors.forename: Roland
authors.initials: R
authors.lastname: Jacobs
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D053583:Interleukin-1beta / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D019562:Viral Load
chemical_list: D053583:Interleukin-1beta