title: [Metformin - new data for an "old", but efficient, safe and reliable antidiabetic drug].
abstract: Metformin is the basic drug of antihyperglycemic therapy in type 2 diabetes: according to actual therapeutic guidelines, it should be given in the absence of contraindications or intolerance during the whole course of the disease even after the initiation of insulin therapy. Recently more and more details have been explored regarding the molecular background of its effects, however, in parallel with the enormous growing knowledge, the number of questions still waiting to be answered has also grown. This review article deals with data already crystallized as well as with details not definitely cleared up. Genetic polymorphisms as well as potential drug interactions influencing the effects of metformin are also briefly summarized.
authors.affiliation: II. Belgyógyászat-Diabetológia, a Semmelweis Egyetem, Általános Orvostudományi Kar Oktató Osztálya, Szent János Kórház Budapest, Diós árok 1-3., 1125.|Elméleti Egészségtudományi Intézet, Miskolci Egyetem, Egészségügyi Kar Miskolc.
authors.forename: Gábor
authors.initials: G
authors.lastname: Winkler
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*; D008687:Metformin / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin; D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases; D055372:AMP-Activated Protein Kinases
keywords: farmakodinamika; farmakokinetika; genetic polymorphisms; genetikai polimorfizmusok; gyógyszer-interakciók; metformin; molecular mechanisms; molekuláris mechanizmusok; pharmacodynamics; pharmacokinetics; potential drug interactions