title: [Evaluation on intestinal absorption of alkaloids extracted by different methods from Rhizoma Coptidis-Rheum rhabarum herbal pair via everted gut sacs].
abstract: The research aimed to evaluate the intestinal absorption of alkaloids extracted by decoction and alcohol extraction proces- ses from Rhizoma Coptidis-Rheum rhabarum herbal pair via everted gut sacs. Berberine, palmatine, coptisine and epiberberine were the main alkaloids in this herbal pair and taken as the standard indexes in the quantitative analysis with multi-components by single marker (QAMS) method, in order to calculate absorption rate constant (Ka) and evaluate intestinal absorption characteristics of these four alkaloids extracted by different extraction methods in different intestinal segments in rats. The results showed that the four alkaloids extracted by two different processes in high, medium and low doses had linear absorption properties in the small intestine segment, which conformed to zero-order absorption rate, intestinal segment than 0.99. The absorption rate constant (Ka) of decoction group was higher than that of alcohol extraction group.
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.forename: Yue-liang
authors.initials: YL
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Yu-ling
authors.initials: YL
authors.lastname: Liu
authors.forename: Jia-qi
authors.initials: JQ
authors.lastname: Wang
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Zhang
authors.forename: Wen-cong
authors.initials: WC
authors.lastname: Liu
mesh_terms: D000470:Alkaloids / Q000493:pharmacokinetics*; D000818:Animals; D039323:Coptis / Q000737:chemistry*; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012250:Rheum / Q000737:chemistry*
chemical_list: D000470:Alkaloids