title: The Influence of Family History Risk Levels of Diabetes on Disease Prevalence in a High-Risk Diabetic Chinese Population.
abstract: Diabetes is associated with genetic susceptibility, and family history is a risk factor. The study investigated the association between different family history risk levels and the prevalence of diabetes in a multi high-risk cohort and evaluated the impact of family history of diabetes on insulin secretion and insulin sensitivity.
  
  
  
  We analyzed data from 9754 adults who participated in the Shanghai High-Risk Diabetic Screen Project between 2002 and 2012. The association among three family history risk levels (mild, moderate, and high) with the prevalence of diabetes, insulin secretion, and insulin sensitivity was evaluated in the multi high-risk cohort.
  
  
  
  Overall, 69.6%, 24.8%, and 5.6% of participants were categorized as having mild, moderate, and high familial risk, respectively. The standardized prevalence was higher in the high family history risk group (43.1%) than in the moderate group (37.3%) and in the mild group (23.5%) (P < 0.001). The odds ratios (ORs) were significantly increased in the moderate group (OR 1.27, 95% confidence interval [CI] 1.15-1.40, P < 0.05) and in the high group (OR 1.69, 95% CI 1.41-2.02, P < 0.05). Among the 3245 normal glucose tolerance participants, insulin secretion significantly declined with increasing levels of family history risk, but there were no significant differences in insulin sensitivity among the three groups.
  
  
  
  The prevalence of diabetes was independently associated with an increasing family history risk level among multi high-risk Chinese populations. Subjects with moderate and high familial history of diabetes displayed a significant decrease in insulin secretion.
authors.affiliation: 1 Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai Key Laboratory of Diabetes, The Metabolic Diseases Biobank, Department of Endocrinology and Metabolism, Shanghai, China .
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Du
authors.affiliation: 2 Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai Key Laboratory of Diabetes, The Metabolic Diseases Biobank, Center for Translational Medicine, Shanghai, China .
authors.forename: Yinan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 3 Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai Key Laboratory of Diabetes, Department of Endocrinology and Metabolism, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Diabetes, Shanghai Diabetes Institute, Shanghai, China .
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
authors.affiliation: 1 Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai Key Laboratory of Diabetes, The Metabolic Diseases Biobank, Department of Endocrinology and Metabolism, Shanghai, China .
authors.forename: Huijuan
authors.initials: H
authors.lastname: Lu
authors.affiliation: 1 Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai Key Laboratory of Diabetes, The Metabolic Diseases Biobank, Department of Endocrinology and Metabolism, Shanghai, China .
authors.forename: Yixie
authors.initials: Y
authors.lastname: Shen
authors.affiliation: 1 Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai Key Laboratory of Diabetes, The Metabolic Diseases Biobank, Department of Endocrinology and Metabolism, Shanghai, China .
authors.forename: Ruihua
authors.initials: R
authors.lastname: Chen
authors.affiliation: 1 Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai Key Laboratory of Diabetes, The Metabolic Diseases Biobank, Department of Endocrinology and Metabolism, Shanghai, China .
authors.forename: Pingyan
authors.initials: P
authors.lastname: Fang
authors.affiliation: 3 Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai Key Laboratory of Diabetes, Department of Endocrinology and Metabolism, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Diabetes, Shanghai Diabetes Institute, Shanghai, China .
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Bao
authors.affiliation: 1 Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai Key Laboratory of Diabetes, The Metabolic Diseases Biobank, Department of Endocrinology and Metabolism, Shanghai, China .
authors.forename: Congrong
authors.initials: C
authors.lastname: Wang
authors.affiliation: 1 Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai Key Laboratory of Diabetes, The Metabolic Diseases Biobank, Department of Endocrinology and Metabolism, Shanghai, China .
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000235:genetics; D005190:Family; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose