title: Cerebral Vasospasm Following Transsphenoidal Hypophysectomy in the Treatment of Lymphocytic Hypophysitis.
abstract: Cerebral vasospasm following transsphenoidal hypophysectomy is an exceedingly rare but serious complication with high morbidity and mortality. The initial signs and symptoms of cerebral vasospasm following transsphenoidal hypophysectomy are changes in mental status, motor deficits, and speech difficulties. Symptomatic vasospasm is difficult to reverse despite treatment and often only resolves with time. Furthermore, most transsphenoidal hypophysectomy patients have been discharged before the onset of vasospasm, so when they do present it is often in a fulminant form and recalcitrant to available treatments.All previously reported patients of cerebral vasospasm following transsphenoidal hypophysectomy were status postresection of a pituitary macroadenoma. The authors report the first patient of vasospasm following transsphenoidal hypophysectomy in the treatment of lymphocytic hypophysitis; a rare inflammatory disorder characterized by lymphocytic infiltration of the pituitary gland causing destruction glandular tissue.
authors.affiliation: *Department of Otolaryngology, Saint Louis University †Department of Neurosurgery, Saint Louis University School of Medicine, Mercy Hospital St. Louis ‡Department of Otolaryngology, Division of Rhinology and Sinus Surgery, Saint Louis University Sinus Institute, Saint Louis University School of Medicine, St. Louis, MO.
authors.forename: Kaveh
authors.initials: K
authors.lastname: Karimnejad
authors.forename: Justin Michael
authors.initials: JM
authors.lastname: Sweeney
authors.forename: Jastin Levi
authors.initials: JL
authors.lastname: Antisdel
mesh_terms: D000069281:Autoimmune Hypophysitis / Q000175:diagnosis / Q000601:surgery*; D001706:Biopsy; D005260:Female; D006801:Humans; D007016:Hypophysectomy / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D010902:Pituitary Gland / Q000000981:diagnostic imaging / Q000601:surgery*; D013101:Sphenoid Sinus; D020301:Vasospasm, Intracranial / Q000209:etiology*; D055815:Young Adult