title: Myeloid derived suppressor cells and autoimmunity.
abstract: Myeloid-derived suppressor cells are a heterogeneous group of immature myeloid cells with immunoregulatory function. When activated and expanded, these cells can suppress T cell functions via cell-to cell interactions as well as soluble mediators. Recent studies investigated the involvement of MDSC in autoimmune diseases. Some papers have described beneficial effect of MDSC during the course of autoimmune diseases, and suggest a potential role as a treatment option, while others failed to detect these effects. Their contributions to autoimmune diseases are not fully understood, and many questions and some controversies remain as to the expansion, activation, and inhibitory functions of MDSC. This review aims to summarize current knowledge of MDSC in autoimmune disorders.
authors.affiliation: Recanati/Miller Transplant Institute, Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10129, USA. Electronic address: peter.boros@mssm.edu.
authors.forename: Peter
authors.initials: P
authors.lastname: Boros
authors.affiliation: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10129, USA.
authors.forename: Jordi
authors.initials: J
authors.lastname: Ochando
authors.affiliation: Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen 4032, Hungary.
authors.forename: Margit
authors.initials: M
authors.lastname: Zeher
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology*; D015551:Autoimmunity; D006801:Humans; D056747:Immunomodulation; D000072737:Myeloid-Derived Suppressor Cells / Q000276:immunology*
keywords: Inflammatory bowel disease; Myeloid derived suppressor cells; Rheumatoid arthritis; SLE; Type 1 diabetes