title: Comparing stimulation requirements and final outcome between early follicular and mid luteal pituitary suppression in the long gonadotropin releasing hormone agonist protocol.
abstract: OBJECTIVE
  To compare stimulation requirements and ICSI outcome when agonist treatment is started in the early follicular phase or in mid luteal phase of the cycle.
  
  
  METHODS
  181 infertile patients were randomly assigned to: group A (N=66) and group B (N=115). GnRH-a (Triptorelin) subcutaneous daily injections started on day 20-22 of the previous cycle till pituitary suppression is achieved where gonadotropins stimulation commenced. In group A, agonist treatment was started on the first or second days of the cycle, in group B it was started on day 20-22 of the cycle. The agonist treatment was continued till the day of (hCG) administration.
  
  
  RESULTS
  The stimulation requirements were similar in the two groups. The days of t agonist treatment required to reach pituitary suppression were higher in group A: 12.5±6.4 than in group B, 11±4.5. Days of stimulation (10.4±1.7 and 10.3±1.6) and number of gonadotropin vials (40.1±8.7and 39.3±9.5) did not differ between both groups. The mean number of oocytes retrieved, mean number of embryos produced (11.7±7.4 and 13.3±9.3) (5.9±4.2and 6±5.2) were similar in both groups. The rates of fertilization and cleavage were similar in the two groups. Pregnancy rates were similar in both groups. The clinical pregnancy rates per cycle was 31.8% and 33%, while pregnancy rates per embryo transfer was 36.2 % and 36.5% in groups A and B respectively.
  
  
  CONCLUSIONS
  Starting pituitary suppression with GnRH agonist in the early follicular phase or mid luteal phase were comparable regarding stimulation requirements and final outcomes.
authors.affiliation: Zagazig University, Egypt.
authors.forename: Abdulmagid
authors.initials: A
authors.lastname: Sarhan
authors.affiliation: Zagazig University, Egypt.
authors.forename: Mervat
authors.initials: M
authors.lastname: Harira
authors.affiliation: Zagazig University, Egypt.
authors.forename: Sherine
authors.initials: S
authors.lastname: Elshazly
authors.affiliation: Zagazig University Student Hospital, Egypt.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Nouh
mesh_terms: D000328:Adult; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage* / Q000627:therapeutic use*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D008183:Luteal Phase; D054315:Oocyte Retrieval / Q000706:statistics & numerical data; D010902:Pituitary Gland / Q000502:physiology; D011247:Pregnancy / Q000706:statistics & numerical data*; D011446:Prospective Studies; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data*; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data
chemical_list: D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone
keywords: GnRH agonist protocol; early follicular; mid luteal; pituitary suppression