title: Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine: a multimodal evoked potentials study.
abstract: BACKGROUND
  Here, we aim to identify cortical electrofunctional correlates of responsiveness to short-lasting preventiveintervention with ketogenic diet (KD) in migraine.
  
  
  METHODS
  Eighteen interictal migraineurs underwent visual (VEPs) and median nerve somatosensory (SSEPs) evokedpotentials before and after 1 month of KD during ketogenesis. We measured VEPs N1-P1 and SSEPs N20-P25 amplitudes respectively in six and in two sequential blocks of 100 sweeps as well as habituation as theslope of the linear regression between block 1 to 6 for VEPs or between 1 to 2 for SSEPs.
  
  
  RESULTS
  After 1-month of KD, a significant reduction in the mean attack frequency and duration was observed (all P< 0.001). The KD did not change the 1st SSEP and VEP block of responses, but significantly inducednormalization of the interictally reduced VEPs and SSEPs (all p < 0.01) habituation during the subsequentblocks.
  
  
  CONCLUSIONS
  KD could restore normal EPs habituation curves during stimulus repetition without significantly changing theearly amplitude responses. Thus, we hypothesize that KD acts on habituation regulating the balancebetween excitation and inhibition at the cortical level.
authors.affiliation: Don Carlo Gnocchi Onlus Foundation, Milan, Italy. cherub@inwind.it.
authors.forename: Cherubino
authors.initials: C
authors.lastname: Di Lorenzo
authors.affiliation: Department of Neurophysiology of Vision and Neurophthalmology, G. B. Bietti Foundation-IRCCS, Rome, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Coppola
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome Polo Pontino, Latina, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Bracaglia
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome Polo Pontino, Latina, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Di Lenola
authors.affiliation: Istituto di Anestesiologia, Rianimazione e Terapia del Dolore, Università Cattolica del Sacro Cuore/CIC, Rome, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Evangelista
authors.affiliation: Delle Medical Center, Wellness and Dietary Medicine, Rome, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Sirianni
authors.affiliation: INI, Headache Clinic, Grottaferrata, (RM), Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Rossi
authors.affiliation: Department of Systems Medicine, University of Rome "Tor Vergata", Laboratory of Psychophysiology, Rome, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Di Lorenzo
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome Polo Pontino, Latina, Italy.
authors.forename: Mariano
authors.initials: M
authors.lastname: Serrao
authors.affiliation: Department of Neurophysiology of Vision and Neurophthalmology, G. B. Bietti Foundation-IRCCS, Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Parisi
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome Polo Pontino, Latina, Italy.|INM Neuromed IRCCS, Pozzilli, (IS), Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Pierelli
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology*; D055423:Diet, Ketogenic; D005071:Evoked Potentials; D005072:Evoked Potentials, Auditory; D005073:Evoked Potentials, Somatosensory; D005074:Evoked Potentials, Visual; D005260:Female; D006185:Habituation, Psychophysiologic; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000178:diet therapy / Q000503:physiopathology* / Q000517:prevention & control*
keywords: Diet; Habituation; Ketogenesis; Migraine; Somatosensory-evoked potentials; Visual-evoked potentials