title: Novel biomarker and easy to perform ELISA for monitoring complement inhibition in patients with atypical hemolytic uremic syndrome treated with eculizumab.
authors.affiliation: Department of Pediatrics, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Riedl
authors.affiliation: Department of Pediatrics, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria.
authors.forename: Johannes
authors.initials: J
authors.lastname: Hofer
authors.affiliation: Department of Pediatrics, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Giner
authors.affiliation: Department of Pediatrics, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Rosales
authors.affiliation: Department of Pediatric Nephrology, University Hospital Freiburg, Mathildenstraße 1, 79106 Freiburg, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Häffner
authors.affiliation: Department of Pediatric Nephrology, Children's Hospital, University of Bern, Freiburgstraße 18, 3010 Bern, Switzerland.
authors.forename: Giacomo D
authors.initials: GD
authors.lastname: Simonetti
authors.affiliation: Department of Pediatric Nephrology, Children's Hospital Augsburg, Stenglinstraße 2, 86156 Augsburg, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Walden
authors.affiliation: Department of Nephrology, Philipps-University Marburg, Baldingerstraße, 35033 Marburg, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Maier
authors.affiliation: Department of Internal Medicine IV-Nephrology and Hypertension, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria.
authors.forename: Dorothea
authors.initials: D
authors.lastname: Heininger
authors.affiliation: Department of Pediatrics, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria.
authors.forename: Verena
authors.initials: V
authors.lastname: Jeller
authors.affiliation: Department of Internal Medicine VI-Infectious Diseases, Immunology, Rheumatology, Pneumology, Innsbruck Medical University, 6020 Innsbruck, Austria.
authors.forename: Günter
authors.initials: G
authors.lastname: Weiss
authors.affiliation: Laboratory of Pediatric Nephrology, Department of Development & Regeneration, KU Leuven, 3000 Leuven, Belgium; Department of Pediatric Nephrology, Radboud University Medical Center, Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, Netherlands.
authors.forename: Lambert
authors.initials: L
authors.lastname: van den Heuvel
authors.affiliation: Department of Pediatrics, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria.
authors.forename: Lothar B
authors.initials: LB
authors.lastname: Zimmerhackl
authors.affiliation: Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Schöpfstraße 41, 6020 Innsbruck, Austria. Electronic address: reinhard.wuerzner@i-med.ac.at.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Würzner
authors.affiliation: Department of Pediatrics, Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria.
authors.forename: Therese C
authors.initials: TC
authors.lastname: Jungraithmayr
mesh_terms: D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D065766:Atypical Hemolytic Uremic Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D015415:Biomarkers / Q000378:metabolism; D003182:Complement C5 / Q000276:immunology / Q000378:metabolism*; D015938:Complement Membrane Attack Complex / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000378:metabolism
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D015415:Biomarkers; D003182:Complement C5; D015938:Complement Membrane Attack Complex; C481642:eculizumab
keywords: Atypical hemolytic uremic syndrome; Complement activation; Eculizumab; Terminal complement complex; Thrombotic microangiopathies