title: Conditioned breathing depression during neonatal life as a function of associating ethanol odor and the drug's intoxicating effects.
abstract: Fetal and neonatal ethanol-related alterations upon the respiratory system have been described in different mammals. Studies also indicate that perinates learn about the sensory attributes of ethanol and associate them with diverse physiological effects of the state of intoxication. The present study was conducted in rat neonates during a developmental stage equivalent to the third human gestational trimester. The major goal was to analyze the consequences of ethanol odor exposure, the state of intoxication, or the temporal contiguity between these factors upon breathing patterns. The main findings were as follows: (a) a conditioned breathing depression was observed following few trials defined by the association between ethanol odor and the state of intoxication and (b) sequential exposure to ethanol sensitizes the organism to the drug's respiratory depressant effects without affecting ethanol metabolism. These results indicate that early breathing disruptions caused by ethanol can be determined or modulated via learning processes. © 2016 Wiley Periodicals, Inc. Dev Psychobiol 58:670-686, 2016.
authors.affiliation: Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Friuli 2434, Córdoba, 5016, Argentina.|Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: A F
authors.initials: AF
authors.lastname: Macchione
authors.affiliation: Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Friuli 2434, Córdoba, 5016, Argentina.
authors.forename: F
authors.initials: F
authors.lastname: Anunziata
authors.affiliation: Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Friuli 2434, Córdoba, 5016, Argentina.
authors.forename: M E
authors.initials: ME
authors.lastname: Culleré
authors.affiliation: Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Friuli 2434, Córdoba, 5016, Argentina.
authors.forename: B O
authors.initials: BO
authors.lastname: Haymal
authors.affiliation: Center for Development and Behavioral Neuroscience, Binghamton University, Binghamton, NY.
authors.forename: N
authors.initials: N
authors.lastname: Spear
authors.affiliation: Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Friuli 2434, Córdoba, 5016, Argentina.|Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: P
authors.initials: P
authors.lastname: Abate
authors.affiliation: Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Friuli 2434, Córdoba, 5016, Argentina.|Center for Development and Behavioral Neuroscience, Binghamton University, Binghamton, NY.|Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, Argentina.
authors.forename: J C
authors.initials: JC
authors.lastname: Molina
mesh_terms: D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D000831:Animals, Newborn; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000502:physiology*; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration / Q000187:drug effects*; D012903:Smell / Q000502:physiology
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol
keywords: breathing depressions; conditioning; neonate ethanol intoxication; sensitization