title: The Prognostic Significance of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Patients With Multiple Myeloma.
abstract: OBJECTIVE
  Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are simple, inexpensive prognostic markers for various conditions. The objective of this study was to determine the prognostic significance of NLR and PLR in patients with multiple myeloma (MM) in terms of survival.
  
  
  METHODS
  A retrospective chart review study was conducted for 175 patients who met the criterion of diagnosis for MM between January 2004 and September 2014.
  
  
  RESULTS
  The median age of diagnosis was 69 years. Patients were divided into high and low NLR and PLR groups according to cutoff points from the receiver operating characteristic curve (2.78 and 155.58, respectively). The high NLR and PLR groups were associated with lower albumin level and higher staging. The high NLR group experienced inferior median survival compared with the low NLR group (37 vs. 66 months; log-rank P-value 0.005). However, there was no significant difference in median survival between the high and low PLR groups (45 vs. 62 months; P = 0.077). Multivariate analysis demonstrated that NLR is an independent predictor for OS of MM (HR 2.892; P = 0.009).
  
  
  CONCLUSIONS
  We conclude that NLR is an independent prognostic factor for OS in MM.
authors.affiliation: Medicine, Einstein Medical Center, Philadelphia, Pennsylvania. supakanya.w@gmail.com.
authors.forename: Supakanya
authors.initials: S
authors.lastname: Wongrakpanich
authors.affiliation: Medicine, Einstein Medical Center, Philadelphia, Pennsylvania.
authors.forename: Gemlyn
authors.initials: G
authors.lastname: George
authors.affiliation: Medicine, Einstein Medical Center, Philadelphia, Pennsylvania.
authors.forename: Wikrom
authors.initials: W
authors.lastname: Chaiwatcharayut
authors.affiliation: Medicine, Einstein Medical Center, Philadelphia, Pennsylvania.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Biso
authors.affiliation: Medicine, Einstein Medical Center, Philadelphia, Pennsylvania.
authors.forename: Nellowe
authors.initials: N
authors.lastname: Candelario
authors.affiliation: Medicine, Einstein Medical Center, Philadelphia, Pennsylvania.
authors.forename: Varun
authors.initials: V
authors.lastname: Mittal
authors.affiliation: Medicine, Einstein Medical Center, Philadelphia, Pennsylvania.
authors.forename: Sherry
authors.initials: S
authors.lastname: Pomerantz
authors.affiliation: Medicine, Einstein Medical Center, Philadelphia, Pennsylvania.
authors.forename: Gabor
authors.initials: G
authors.lastname: Varadi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000969:Antinematodal Agents; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001792:Blood Platelets / Q000473:pathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000188:drug therapy; D009504:Neutrophils / Q000473:pathology*; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
chemical_list: D000969:Antinematodal Agents; D000970:Antineoplastic Agents
keywords: multiple myeloma; neutrophil-to-lymphocyte ratio; overall survival; platelet-to-lymphocyte ratio; prognostic marker