title: Transcription Factor NF-κB: An Update on Intervention Strategies.
abstract: The nuclear factor (NF)-κB family of transcription factors are ubiquitous and pleiotropic molecules that regulate the expression of more than 150 genes involved in a broad range of processes including inflammation, immunity, cell proliferation, differentiation, and survival. The chronic activation or dysregulation of NF-κB signaling is the central cause of pathogenesis in many disease conditions and, therefore, NF-κB is a major focus of therapeutic intervention. Because of this, understanding the relationship between NF-κB and the induction of various downstream signaling molecules is imperative. In this review, we provide an updated synopsis of the role of NF-κB in DNA repair and in various ailments including cardiovascular diseases, HIV infection, asthma, herpes simplex virus infection, chronic obstructive pulmonary disease, and cancer. Furthermore, we also discuss the specific targets for selective inhibitors and future therapeutic strategies.
authors.affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA.|Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, 70803, USA.
authors.forename: Arvind
authors.initials: A
authors.lastname: Panday
authors.affiliation: Departamento de Microbiología, CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional Rosario, Suipacha 531, Santa Fe, Argentina.
authors.forename: Maria Eugenia
authors.initials: ME
authors.lastname: Inda
authors.affiliation: Laboratory of Pulmonary Immunotoxicology, Environmental Toxicology PhD Program, 207 Health Research Center, Southern University and A&M College, Baton Rouge, LA, 70813, USA.
authors.forename: Prathyusha
authors.initials: P
authors.lastname: Bagam
authors.affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94304, USA.
authors.forename: Malaya K
authors.initials: MK
authors.lastname: Sahoo
authors.affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Osorio
authors.affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA. sanjay_batra@subr.edu.|Laboratory of Pulmonary Immunotoxicology, Environmental Toxicology PhD Program, 207 Health Research Center, Southern University and A&M College, Baton Rouge, LA, 70813, USA. sanjay_batra@subr.edu.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Batra
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology; D002318:Cardiovascular Diseases / Q000276:immunology; D002454:Cell Differentiation; D049109:Cell Proliferation; D002470:Cell Survival; D004249:DNA Damage; D015658:HIV Infections / Q000276:immunology; D006561:Herpes Simplex / Q000276:immunology; D006801:Humans; D007107:Immune System; D007249:Inflammation; D016328:NF-kappa B / Q000276:immunology* / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology; D029424:Pulmonary Disease, Chronic Obstructive / Q000276:immunology; D015398:Signal Transduction
chemical_list: D016328:NF-kappa B
keywords: Asthma; COPD; Cancer; DNA damage; HIV; HSV; NF-κB