title: [Acute-on-chronic liver failure - new Definition of a complex clinical picture].
abstract: Acute-on-chronic liver failure (ACLF) is characterized by a sudden onset of decompensation in patients with preexisting liver disease followed by subsequent organ failure and high short-term mortality. ACLF is extremely heterogeneous in terms of predisposing stage of liver disease, precipitating events, and the course of organ failure and has been defined differently by different medical associations in the East and in the West. A recent consensus working definition is the basis for further research in order to understand underlying pathophysiological mechanisms, to establish diagnostic and prognostic biomarkers, and to implement risk-adapted treatment strategies.
authors.forename: Tony
authors.initials: T
authors.lastname: Bruns
authors.forename: Andreas
authors.initials: A
authors.lastname: Stallmach
mesh_terms: D065290:Acute-On-Chronic Liver Failure / Q000145:classification / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D001424:Bacterial Infections / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D032921:Consensus; D003404:Creatinine / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D008111:Liver Function Tests; D009102:Multiple Organ Failure / Q000145:classification / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D051437:Renal Insufficiency / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D015996:Survival Rate; D016896:Treatment Outcome; D014944:World Health Organization
chemical_list: D015415:Biomarkers; D003404:Creatinine