title: Analysis of risk factors leading to postoperative urethral stricture and bladder neck contracture following transurethral resection of prostate.
abstract: OBJECTIVE
  To determine risk factors of postoperative urethral stricture (US) and vesical neck contracture (BNC) after transurethral resection of prostate (TURP) from perioperative parameters.
  
  
  METHODS
  373 patients underwent TURP in a Chinese center for lower urinary tract symptoms suggestive of benign prostatic obstruction (LUTS/BPO), with their perioperative and follow-up clinical data being collected. Univariate analyses were used to determine variables which had correlation with the incidence of US and BNC before logistic regression being applied to find out independent risk factors.
  
  
  RESULTS
  The median follow-up was 29.3 months with the incidence of US and BNC being 7.8% and 5.4% respectively. Resection speed, reduction in hemoglobin (ΔHb) and hematocrit (ΔHCT) levels, incidence of urethral mucosa rupture, re-catheterization and continuous infection had significant correlation with US, while PSA level, storage score, total prostate volume (TPV), transitional zone volume (TZV), transitional zone index (TZI), resection time and resected gland weight had significant correlation with BNC. Lower resection speed (OR=0.48), urethral mucosa rupture (OR=2.44) and continuous infection (OR=1.49) as well as higher storage score (OR=2.51) and lower TPV (OR=0.15) were found to be the independent risk factors of US and BNC respectively.
  
  
  CONCLUSIONS
  Lower resection speed, intraoperative urethral mucosa rupture and postoperative continuous infection were associated with a higher risk of US while severer storage phase symptom and smaller prostate size were associated with a higher risk of BNC after TURP.
authors.affiliation: Department of Urology, Anhui Provincial Hospital,Hefei, Anhui, China.
authors.forename: Huang
authors.initials: H
authors.lastname: Tao
authors.affiliation: Department of Urology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Yu Yong
authors.initials: YY
authors.lastname: Jiang
authors.affiliation: Department of Urology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Jun
authors.affiliation: Department of Urology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Urology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Duan Liu
authors.initials: DL
authors.lastname: Jian
authors.affiliation: Department of Urology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Ding
authors.initials: D
authors.lastname: Jie
authors.affiliation: Department of Urology, Anhui Provincial Hospital,Hefei, Anhui, China.
authors.forename: Zhu Yu
authors.initials: ZY
authors.lastname: Ping
mesh_terms: D000368:Aged; D003286:Contracture / Q000209:etiology*; D006801:Humans; D016015:Logistic Models; D059411:Lower Urinary Tract Symptoms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology*; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000601:surgery*; D012372:ROC Curve; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D013997:Time Factors; D020728:Transurethral Resection of Prostate / Q000009:adverse effects*; D016896:Treatment Outcome; D014525:Urethral Stricture / Q000209:etiology*; D001748:Urinary Bladder Neck Obstruction / Q000209:etiology*