title: Biodegradable Polymeric Nanoparticles as the Delivery Carrier for Drug.
abstract: BACKGROUND
  Drug research and development has entered into the new epoch of innovation formulation, and the drug delivery system has been in the forefront of pharmaceutical innovation. Nanotechnology is widely used in fiber and textiles, electronics, space, agriculture, forensic science and medical therapeutics. It increasingly plays a significant role in drug delivery system. Compared with traditional delivery system, the nanoparticle drug delivery system has lots of merits, such as the high drug loading ability, the excellent biocompatibility, low toxicity, controlled and targeted drug release.
  
  
  METHODS
  We undertook a structured research of biodegradable polymeric nanoparticles used as delivery carrier for drug using a focused review question and inclusion/exclusion criteria. We have searched the bibliographic databases for peerreviewed research literature. The outstanding characteristics of the screened papers were described respectively, and a systematic content analysis methodology was used to analysis the findings.
  
  
  RESULTS
  Seventy-three papers were included in the review, the majority defined leadership and governance approaches that had impacted upon the polymeric nanoparticles as the delivery carrier for drug in therapeutic applications and developments. Seven papers outlined the superiority characteristics of polymeric nanoparticles that applied in the field of vaccine. Forty-seven papers overviewed the application prospects of polymeric nanoparticles used as drug delivery carrier for cancer. These included current advances in research and clinical applications of polymeric nanoparticles. The review identified the drug delivery carrier of biodegradable polymeric nanoparticles, and we described the synthesis methods, applications and challenges of polymeric nanoparticles.
  
  
  CONCLUSIONS
  The findings of this review identified that the biodegradable polymeric nanoparticles were used as delivery carrier for drug currently. It also indicates that the biodegradable polymeric nanoparticles play an important role in the drug delivery.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhao
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Ci
authors.initials: C
authors.lastname: Shi
authors.forename: Xueling
authors.initials: X
authors.lastname: Ma
authors.forename: Guangu
authors.initials: G
authors.lastname: Rong
authors.forename: Hong
authors.initials: H
authors.lastname: Kang
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, 163319 China. mulberrysnow@msn.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Sun
mesh_terms: D001672:Biocompatible Materials; D004337:Drug Carriers; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D011108:Polymers