title: A Novel Device for the Evaluation of Hemostatic Function in Critical Care Settings.
abstract: Major surgical procedures often result in significant intra- and postoperative bleeding. The ability to identify the cause of the bleeding has the potential to reduce the transfusion of blood products and improve patient care. We present a novel device, the Quantra Hemostasis Analyzer, which has been designed for automated, rapid, near-patient monitoring of hemostasis. The Quantra is based on Sonic Estimation of Elasticity via Resonance Sonorheometry, a proprietary technology that uses ultrasound to measure clot time and clot stiffness from changes in viscoelastic properties of whole blood during coagulation. We present results of internal validation and analytical performance testing of the technology and demonstrate the ability to characterize the key functional components of hemostasis.
authors.affiliation: From *HemoSonics LLC, Charlottesville, Virginia; and †University of Virginia, Charlottesville, Virginia.
authors.forename: Elisa A
authors.initials: EA
authors.lastname: Ferrante
authors.forename: Kiev R
authors.initials: KR
authors.lastname: Blasier
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Givens
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Lloyd
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Fischer
authors.forename: Francesco
authors.initials: F
authors.lastname: Viola
mesh_terms: D001331:Automation; D001777:Blood Coagulation; D001780:Blood Coagulation Tests / Q000295:instrumentation* / Q000592:standards; D001809:Blood Viscosity; D002138:Calibration; D003422:Critical Care; D055119:Elastic Modulus; D004867:Equipment Design; D018056:Hemorheology; D006487:Hemostasis; D006801:Humans; D011237:Predictive Value of Tests; D012015:Reference Standards; D015203:Reproducibility of Results; D012212:Rheology / Q000295:instrumentation* / Q000592:standards; D013997:Time Factors; D014465:Ultrasonics / Q000295:instrumentation* / Q000592:standards