title: Serum insulin-like growth factor-1 levels in patients with pseudoexfoliation syndrome and glaucoma.
abstract: Insulin-like growth factor-1 (IGF-1) is altered in several neurodegenerative diseases, the association between serum IGF-1 levels and glaucoma has not been evaluated. This study was designed to evaluate whether serum IGF-1 levels are different in patients with Pseudoexfoliation (PEX) with or without glaucoma. The study was conducted with 110 participants aged 65 years or older who were divided into three groups: group 1, patients with PEX syndrome; group 2, patients with PEX glaucoma; and group 3, participants without PEX or glaucoma. All participants underwent full ophthalmological examination and a detailed medical history was recorded. Patients with known neurodegenerative diseases other than PEX glaucoma were excluded. Serum IGF-1 levels were measured by automated chemiluminescent assay. Groups 1, 2, and 3 included 35, 34, and 41 patients, respectively; there were no differences regarding age, gender, or systemic disease status. There were also no statistically significant differences between the groups in terms of IGF-1 levels, which were 91.7 ± 39.1, 101.1 ± 40.2, and 107.2 ± 43.8 ng/ml for groups 1, 2, and 3, respectively (p = 0.276). Serum IGF-1 levels were similar by gender, the presence of systemic disease, status of diabetes mellitus, and laterality of the PEX material. There was no correlation between the cup-to-disk ratios and IGF-1 levels (r = -0.214, p = 0.223). IGF-1 levels in the circulation did not differ in the presence of PEX syndrome with or without glaucoma. This may indicate that the neurodegenerative process is local rather than systemic.
authors.affiliation: Departments of Ophthalmology, Ministry of Health, Diskapi Yildirim Beyazit Training and Research Hospital, İrfan Baştuğ Cad., Dışkapı, Ankara, Turkey. asanaldogan@gmail.com.
authors.forename: Aysun Sanal
authors.initials: AS
authors.lastname: Dogan
authors.affiliation: Departments of Ophthalmology, Ministry of Health, Diskapi Yildirim Beyazit Training and Research Hospital, İrfan Baştuğ Cad., Dışkapı, Ankara, Turkey.
authors.forename: Naciye
authors.initials: N
authors.lastname: Kabatas
authors.affiliation: Departments of Biochemistry, Ministry of Health, Diskapi Yildirim Beyazit Training and Research Hospital, İrfan Baştuğ Cad., Dışkapı, Ankara, Turkey.
authors.forename: Gonul
authors.initials: G
authors.lastname: Erden
authors.affiliation: Departments of Ophthalmology, Ministry of Health, Diskapi Yildirim Beyazit Training and Research Hospital, İrfan Baştuğ Cad., Dışkapı, Ankara, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Celikay
authors.affiliation: Departments of Biochemistry, Ministry of Health, Diskapi Yildirim Beyazit Training and Research Hospital, İrfan Baştuğ Cad., Dışkapı, Ankara, Turkey.
authors.forename: Abdullah Ercan
authors.initials: AE
authors.lastname: Arzuhal
authors.affiliation: Departments of Ophthalmology, Ministry of Health, Diskapi Yildirim Beyazit Training and Research Hospital, İrfan Baştuğ Cad., Dışkapı, Ankara, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Gurdal
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D017889:Exfoliation Syndrome / Q000097:blood* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007429:Intraocular Pressure; D008163:Luminescent Measurements; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D007334:Insulin-Like Growth Factor I
keywords: Glaucoma; Insulin-like growth factor-1; Pseudoexfoliation; Serum levels