title: Protective role of miR-23b-3p in kainic acid-induced seizure.
abstract: Dysregulation of microRNAs has been proposed to contribute toward epilepsy. The miRNA miR-23b-3p has been found to protect against neuronal apoptosis and the production of reactive oxygen species. In this study, we assessed the potential role of miR-23b-3p in the kainic acid (KA)-induced seizure model. We found that miR-23b-3p levels were significantly decreased in the brain cortex of mice and in cultured mouse primary neurons treated with KA. Importantly, supplement of miR-23b-3p agomir by an intacerebroventricular injection alleviated seizure behaviors and abnormal cortical electroencephalogram recordings in KA-treated mice. Together, these results indicate that miR-23b-3p plays a crucial role in suppressing seizure formation in experimental models of epilepsy and that miR-23b-3p supplement may be a potential anabolic strategy for ameliorating seizure.
authors.affiliation: aNeuromedicine Center, the 174th Hospital of Chinese People's Liberation Army, Affiliated Chenggong Hospital, Xiamen University bFujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine cDepartment of Neurology, Affiliated Zhongshan Hospital, Xiamen University dDepartment of Neurology, Affiliated Zhongshan Hospital, Fujian Medical College, Xiamen, Fujian Province, China.
authors.forename: Lianbo
authors.initials: L
authors.lastname: Zhan
authors.forename: Yi
authors.initials: Y
authors.lastname: Yao
authors.forename: Huajun
authors.initials: H
authors.lastname: Fu
authors.forename: Zhenghui
authors.initials: Z
authors.lastname: Li
authors.forename: Fengpeng
authors.initials: F
authors.lastname: Wang
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Zhang
authors.forename: Wencan
authors.initials: W
authors.lastname: He
authors.forename: Weihong
authors.initials: W
authors.lastname: Zheng
authors.forename: Yunwu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Honghua
authors.initials: H
authors.lastname: Zheng
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology*; D007608:Kainic Acid / Q000008:administration & dosage; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000378:metabolism*; D061251:Primary Cell Culture; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; C534062:Mirn23b microRNA, mouse; D007608:Kainic Acid