title: Preoperative Endoscopic Biliary Drainage May Negatively Impact Survival Following Pancreatoduodenectomy for Ampullary Cancer.
abstract: OBJECTIVE
  Ampullary carcinoma is a rare tumour with a high resectability rate. There is an increasing body of evidence indicating not only tumour-related factors, but also jaundice influence survival following curative resection. Several modalities for preoperative biliary drainage are available; however, routine preoperative endoscopic biliary drainage (PEBD) is not recommended. There is no sufficient data regarding the impact of PEBD on long-term outcomes. The aim of our study was to identify predictive factors of survival with special regard to PEBD in patients undergoing curative resection for ampullary carcinoma.
  
  
  METHODS
  Data from 64 consecutive patients with adenocarcinoma of the papilla of Vater who have been operated on was analysed. Overall survival was defined from the date of surgery to the date of death, or censored at the last patient contact. Survival analysis was determined by means of the Kaplan-Meier method. The significance of the demographic, clinical and histopathologic factors was ascertained by the log-rank test. A Cox proportional hazard model was used to determine independent prognostic factors of survival.
  
  
  RESULTS
  Twenty patients (31.2%) underwent PEBD. Univariate analysis revealed tumour-related factors, age over 70, and PEBD to negatively influence survival. Five of them (excluding T stage) were identified as the independent prognosticators, while PEBD appeared to be the most decisive factor. Median survival for patients who underwent PEBD was 25.3 months as compared to 112.9 months for those who did not. In conclusion, PEBD negatively affected long-term outcomes in our patients with resected ampullary carcinoma.
authors.affiliation: Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Giedrius
authors.initials: G
authors.lastname: Barauskas
authors.forename: Kestutis
authors.initials: K
authors.lastname: Urbonas
authors.forename: Giedre
authors.initials: G
authors.lastname: Smailyte
authors.forename: Darius
authors.initials: D
authors.lastname: Pranys
authors.forename: Juozas
authors.initials: J
authors.lastname: Pundzius
authors.forename: Antanas
authors.initials: A
authors.lastname: Gulbinas
mesh_terms: D000208:Acute Disease; D000230:Adenocarcinoma / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater; D002761:Cholangitis / Q000628:therapy; D003138:Common Bile Duct Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D004322:Drainage; D016145:Endoscopy, Digestive System; D005260:Female; D006801:Humans; D041781:Jaundice, Obstructive / Q000628:therapy; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D055806:Microvessels / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016577:Pancreaticoduodenectomy; D011300:Preoperative Care; D016016:Proportional Hazards Models; D012307:Risk Factors; D015607:Stents; D015996:Survival Rate