title: Organization and mode of action of two component system signaling circuits from the various kingdoms of life.
abstract: Two-component system (TCS) signaling circuits regulate numerous cellular processes in response to environmental cues in both prokaryotic and eukaryotic cells. These signaling circuits are all based on phosphoryl-group transfers between histidine and aspartate containing modules of sensor kinase and response regulator proteins. Curiously, the architecture and organization of prokaryotic and eukaryotic two-component systems reveal notable variations, raising the question of whether the input-response specificity that governs the majority of prokaryotic TCSs also governs the eukaryotic ones. In this review, we contrast the TCS architecture and signaling circuits of prokaryotes and eukaryotes, and discuss their possible consequences on signaling specificity.
authors.affiliation: Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510, México City, México.
authors.forename: Adrian F
authors.initials: AF
authors.lastname: Alvarez
authors.affiliation: Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510, México City, México.
authors.forename: Carlos
authors.initials: C
authors.lastname: Barba-Ostria
authors.affiliation: Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510, México City, México.
authors.forename: Hortencia
authors.initials: H
authors.lastname: Silva-Jiménez
authors.affiliation: Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510, México City, México. dimitris@ifc.unam.mx.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Georgellis
mesh_terms: D001224:Aspartic Acid / Q000737:chemistry; D017753:Ecosystem; D005057:Eukaryotic Cells / Q000378:metabolism*; D006639:Histidine / Q000737:chemistry; D011387:Prokaryotic Cells / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D001224:Aspartic Acid; D006639:Histidine