title: Effect on Clinical Restenosis of an Ultra-Thin-Strut Bare Metal Cobalt-Chromium Stent Versus a Thin-Strut Stainless Steel Stent.
abstract: OBJECTIVE
  To prospectively compare the impact of ultrathin-strut cobalt-chromium (Cro-Co) bare metal stent (BMS) versus thin-strut stainless steel (SS) BMS on clinically driven target lesion revascularization (TLR).
  
  
  BACKGROUND
  Stent characteristics are an important determinant of restenosis. Thinner strut Cro-Co BMS is associated with a reduction of neointimal formation compared to SS BMS. The advantages of Cro-Co BMS in a real-world population is not clear.
  
  
  METHODS
  Patients undergoing percutaneous coronary intervention (PCI) with BMS for any reason were enrolled. Patient with multi-vessel PCI, multi-lesions PCI, PCI of unprotected left main and coronary grafts were not excluded. They were divided in two groups according to stent type: Cro-Co or SS group. The primary endpoint was clinically driven TLR at follow-up.
  
  
  RESULTS
  A total of 383 patients were enrolled: 222 in SS and 161 in Cro-Co group. During the follow-up, Cro-Co patients had a significantly lower occurrence of TLR compared to SS patients (1.9% vs 8.6%, P = 0.006). There were no significant differences for the composite endpoint of death, myocardial infarct, and stroke (4.9% in Cro-Co group vs 9.5% in SS group, P = 0.119). At multivariate analysis, the variables that were predictors of TLR were: use of SS stent (OR 4.43, P = 0.019) and diabetes (OR 2.84, P = 0.025).
  
  
  CONCLUSIONS
  Ultra-thin strut Cro-Co BMS is associated with a significant reduction of clinically driven TLR in all comers population with any type of coronary disease complexity. (J Interven Cardiol 2016;29:300-310).
authors.affiliation: Department of Cardiology, Mazzoni Hospital, Ascoli Piceno, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Silenzi
authors.affiliation: Department of Cardiology, Mazzoni Hospital, Ascoli Piceno, Italy.
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Grossi
authors.affiliation: Department of Cardiology, Mazzoni Hospital, Ascoli Piceno, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Mariani
authors.affiliation: Division of Cardiology, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Fraccaro
authors.affiliation: Division of , Cardiology, Department of Experimental Diagnostic and Specialty Medicine, Alma Mater Studiorum-University of Bologna, Bologna, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Vagnarelli
authors.affiliation: Department of Cardiology, Mazzoni Hospital, Ascoli Piceno, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Moretti
mesh_terms: D000368:Aged; D002857:Chromium / Q000009:adverse effects / Q000627:therapeutic use; D003035:Cobalt / Q000009:adverse effects / Q000627:therapeutic use; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000601:surgery*; D023903:Coronary Restenosis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D058426:Neointima; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods*; D011446:Prospective Studies; D011474:Prosthesis Design; D013193:Stainless Steel / Q000009:adverse effects; D015607:Stents; D016896:Treatment Outcome
chemical_list: D002857:Chromium; D013193:Stainless Steel; D003035:Cobalt