title: From IBS to DBS: The Dysbiotic Bowel Syndrome.
abstract: Irritable bowel syndrome is a chronic gastrointestinal disorder characterized by abdominal pain and altered bowel habits in the absence of organic disease. We present 2 cases where diarrhea-predominant irritable bowel syndrome occurred in association with earlier intestinal infection or antibiotic treatment. Both were successfully treated with instillation of an anaerobic cultivated human intestinal microbiota. Thereafter, they were symptom free for at least 12 months. We now introduce the term dysbiotic bowel syndrome covering cases where a disturbed intestinal microbiota is assumed to be present. We recommend that restoration of the dysbiotic gut microbiota should be first-line treatment in these conditions.
authors.affiliation: Läkarhuset Hötorgscity, Stockholm, Sweden; Karolinska Institutet, Stockholm, Sweden.
authors.forename: Peter
authors.initials: P
authors.lastname: Benno
authors.affiliation: Karolinska Institutet, Stockholm, Sweden.
authors.forename: Atti-La
authors.initials: AL
authors.lastname: Dahlgren
authors.affiliation: Läkarhuset Hötorgscity, Stockholm, Sweden.
authors.forename: Ragnar
authors.initials: R
authors.lastname: Befrits
authors.affiliation: Karolinska Institutet, Stockholm, Sweden.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Norin
authors.affiliation: Uppsala University, Uppsala, Sweden.
authors.forename: Per M
authors.initials: PM
authors.lastname: Hellström
authors.affiliation: Karolinska Institutet, Stockholm, Sweden.
authors.forename: Tore
authors.initials: T
authors.lastname: Midtvedt
keywords: diarrhea; dysbiosis; irritable bowel syndrome; microbiota; pain; postinfectious IBS