title: Self-induced drug intoxication in baclofen: of the calm hypotonic coma in the status epilepticus.
abstract: Baclofen is an agonist of peripheral and central B gamma-aminobutyric acid receptors, whose activation causes a myorelaxation and a powerfull depression of the central nervous system. Moreover, it has an action against addiction, in reducing craving. Commercialized since 1975 in France, to control muscle spasticity due to medullar affection or multiple sclerosis, it receives a temporary recommendation of use in march 2014, as a last-line adjuvant treatment in alcohol withdrawal. Beyond its therapeutic use, baclofen is involved in many self-induced intoxications. We report the case of a patient who develops, after a massive ingestion of baclofen (supposed dose ingested: 1 200 mg), a hypotonic and calm coma, requiring her admission in our intensive care unit, and then a status epilepticus.
authors.affiliation: Pôle bloc anesthésie réanimation urgences, Hôpital d'instruction des armées Clermont Tonnerre, BCRM de Brest, France.
authors.forename: Chloé
authors.initials: C
authors.lastname: Thill
authors.affiliation: Laboratoire de biologie médicale, Hôpital d'instruction des armées Clermont Tonnerre, BCRM de Brest, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Di Constanzo
authors.affiliation: Pôle bloc anesthésie réanimation urgences, Hôpital d'instruction des armées Clermont Tonnerre, BCRM de Brest, France.
authors.forename: François
authors.initials: F
authors.lastname: Pessey
authors.affiliation: Pôle bloc anesthésie réanimation urgences, Hôpital d'instruction des armées Clermont Tonnerre, BCRM de Brest, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Aries
authors.affiliation: Pôle bloc anesthésie réanimation urgences, Hôpital d'instruction des armées Clermont Tonnerre, BCRM de Brest, France.
authors.forename: Étienne
authors.initials: É
authors.lastname: Montelescaut
authors.affiliation: Laboratoire de biologie médicale, Hôpital d'instruction des armées Clermont Tonnerre, BCRM de Brest, France.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Sapin
authors.affiliation: Laboratoire de biologie médicale, Hôpital d'instruction des armées Clermont Tonnerre, BCRM de Brest, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Vaillant
authors.affiliation: Laboratoire de biologie médicale, Hôpital d'instruction des armées Clermont Tonnerre, BCRM de Brest, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Drouillard
mesh_terms: D001418:Baclofen / Q000506:poisoning*; D003128:Coma / Q000139:chemically induced* / Q000150:complications; D062787:Drug Overdose / Q000175:diagnosis*; D005260:Female; D005602:France; D006801:Humans; D008875:Middle Aged; D009123:Muscle Hypotonia / Q000139:chemically induced / Q000150:complications; D016728:Self-Injurious Behavior / Q000150:complications / Q000175:diagnosis; D013226:Status Epilepticus / Q000139:chemically induced* / Q000150:complications; D013375:Substance Withdrawal Syndrome / Q000150:complications
chemical_list: D001418:Baclofen
keywords: alcohol withdrawal; baclofen; coma; self-induced intoxication; status epilepticus