title: Current and Emerging Aspects of Diabetes Mellitus in Acromegaly.
abstract: Diabetes mellitus is a frequent complication of acromegaly, a disease characterized by chronic hypersecretion of growth hormone (GH) by a pituitary adenoma. Diabetes occurs commonly but not only as a consequence of an insulin-resistant state induced by GH excess. The development of diabetes in patients with acromegaly is clinically relevant, since such a complication is thought to increase the already elevated cardiovascular morbidity and mortality risk of the disease. Emerging data suggest that a specific cardiomyopathy can be identified in acromegaly patients with diabetes. Moreover, the presence of diabetes may also influence therapeutic decision making in acromegaly, since traditional and newly developed drugs used in this clinical setting may impact glucose metabolism regardless of control of GH hypersecretion.
authors.affiliation: Endocrinology and Metabolic Diseases Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Frara
authors.affiliation: Endocrinology and Metabolic Diseases Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Maffezzoni
authors.affiliation: Endocrine Unit, ASST Carlo Poma, 46100 Mantova, Italy.
authors.forename: Gherardo
authors.initials: G
authors.lastname: Mazziotti
authors.affiliation: Endocrinology and Metabolic Diseases Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. Electronic address: a.giustina@libero.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Giustina
mesh_terms: D000172:Acromegaly / Q000378:metabolism*; D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism; D019382:Human Growth Hormone / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D010911:Pituitary Neoplasms / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism
chemical_list: D019382:Human Growth Hormone; D013004:Somatostatin; D013006:Growth Hormone; C406545:pegvisomant
keywords: acromegaly; cardiovascular risk; diabetes; medical therapy; pegvisomant; somatostatin analogs