title: Functionalized Conjugated Polyelectrolytes for Biological Sensing and Imaging.
abstract: Conjugated polyelectrolytes (CPEs) are macromolecules with highly delocalized π-conjugated backbones and charged side chains, which are unique types of active materials, with wide applications in optoelectronics, sensing, imaging, and therapy. By attaching specific groups (e.g., recognition elements, magnetic resonance (MR) contrast agents, gene carriers, and drugs) to the side chain or backbone of CPEs, functionalized CPEs have been developed and used for specific biological applications. In this account, we summarize the recent progress of functionalized CPEs with respect to their synthesis and biomedical applications. Future perspectives are also discussed at the end.
authors.affiliation: School of Materials Science and Engineering, Tongji University, 4800 Caoan Road, Shanghai, 201804, P. R. China.
authors.forename: Ruoyu
authors.initials: R
authors.lastname: Zhan
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore 4 Engineering Drive 4117585 Singapore (Republic of Singapore) and Institution of Materials Research and Engineering A*STAR3 Research Link, 117602, Singapore, Republic of Singapore.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
mesh_terms: D000818:Animals; D001419:Bacteria / Q000302:isolation & purification; D015374:Biosensing Techniques; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry; D004247:DNA / Q000032:analysis; D004337:Drug Carriers / Q000737:chemistry; D018014:Gene Transfer Techniques; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008670:Metals / Q000032:analysis; D018613:Microscopy, Confocal; D000071228:Polyelectrolytes / Q000138:chemical synthesis / Q000737:chemistry*; D014780:Viruses / Q000302:isolation & purification
chemical_list: D003287:Contrast Media; D004337:Drug Carriers; D006023:Glycoproteins; D008670:Metals; D000071228:Polyelectrolytes; D004247:DNA
keywords: conjugation; imaging agents; polymers; sensors; therapy