title: The impact of premature progesterone rise on the outcome of intrauterine insemination cycles with controlled ovarian hyperstimulation in unexplained infertility.
abstract: OBJECTIVE
  To ascertain the incidence of premature progesterone P rise and its impact on outcomes in controlled ovarian hyperstimulation and intrauterine insemination (COH-IUI) cycles, and also to identify variables related with premature P rise.
  
  
  METHODS
  Four hundred sixty cycles of 460 couples with unexplained infertility having COH-IUI treatment with a starting dose of 75IU recombinant FSH enrolled in this prospective study. Serum P levels were determined on the day of hCG trigger. Premature P rise was defined as progesterone ≥1ng/mL. The primary outcome measure was live birth per cycle with regard to P levels of ≥1ng/mL and ≥1.5ng/mL. Secondary outcome measures were cycle characteristics associated with P rise.
  
  
  RESULTS
  The incidence of premature P rise was 22.0%. P levels on hCG day were significantly lower in cycles with live birth as compared to cycles without live birth 0.49±0.51 vs. 0.73±0.82ng/mL. Live birth rates were significantly lower in cycles with hCG day P levels ≥1.0ng/mL (%7.9 vs. %22.6) and ≥1.5ng/mL (%6.4 vs. %20.8). Among age, number of dominant follicles, estradiol, LH and P levels on the day of hCG trigger, it was found that P levels was the only significant variable to predict live birth on multivariate analysis. The number of dominant follicles on hCG day and premature LH surge were the only significant variables related with premature P rise.
  
  
  CONCLUSIONS
  Premature P is a frequent feature of COH-IUI cycles and associated with decreased live birth rates.
authors.affiliation: Department of Obstetrics & Gynecology, Yuksek Ihtisas University Faculty of Medicine, Ankara, Turkey. Electronic address: firatmutlu78@hotmail.com.
authors.forename: Mehmet Firat
authors.initials: MF
authors.lastname: Mutlu
authors.affiliation: Department of Obstetrics & Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erdem
authors.affiliation: Department of Obstetrics & Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Erdem
authors.affiliation: IVF Unit, Novaart IVF and Women Health Center, Ankara, Turkey.
authors.forename: Ilknur
authors.initials: I
authors.lastname: Mutlu
authors.affiliation: Department of Obstetrics & Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Guler
authors.affiliation: Department of Obstetrics &Gynecology, Etlik Zubeyde Hanım Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Erhan
authors.initials: E
authors.lastname: Demirdağ
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000628:therapy*; D007315:Insemination, Artificial; D050498:Live Birth; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D011374:Progesterone / Q000097:blood*; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D011374:Progesterone
keywords: Insemination; Live birth rate; Ovarian hyperstimulation; Progesterone