title: Near infrared light responsive hybrid nanoparticles for synergistic therapy.
abstract: A near infrared (NIR) light responsive chromophore 7-(diethylamino)-4-(hydroxymethyl)-2H-chromen-2-one (DEACM) was synthesized and incorporated to β-cyclodextrins with cRGD functionalized poly(ethylene glycol), the amphiphiles were coordinated with Au nanorods or nanoparticles to load anticancer drug doxorubicin (DOX) for fabricating hybrid nanoparticles. The π-π stacking interaction between DEACM and DOX was formed in the hybrid nanoparticles, which contributed to the high drug loading content. The Au nanorods or nanoparticles enhanced the photosolvolysis of DEACM under the irradiation of NIR with 808 nm wavelength and triggered the accelerated drug release from the nanoparticles. The drug loaded hybrid nanoparticles with NIR irradiation exhibited efficient inhibition effect on the proliferation of 4T1 breast cancer cells in vitro. The in vivo anticancer activity study on breast cancer bearing mice revealed that the hybrid nanoparticles containing Au nanorods exhibited excellent anticancer activity under the irradiation of 808 nm wavelength NIR with 800 mW.
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China. Electronic address: wenxiag@wzu.edu.cn.
authors.forename: Wenxia
authors.initials: W
authors.lastname: Gao
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Peng
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Deng
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
authors.forename: Changzhen
authors.initials: C
authors.lastname: Sun
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China.
authors.forename: Huayue
authors.initials: H
authors.lastname: Wu
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. Electronic address: bhe@scu.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: He
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001578:Benzopyrans / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006046:Gold / Q000737:chemistry; D007259:Infrared Rays; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000737:chemistry; D043942:Nanotubes / Q000737:chemistry; D041681:NIH 3T3 Cells; D010456:Peptides, Cyclic / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D004195:Disease Models, Animal
chemical_list: D000970:Antineoplastic Agents; D001578:Benzopyrans; D047392:beta-Cyclodextrins; C507169:cyclic arginine-glycine-aspartic acid peptide; D004317:Doxorubicin; D006046:Gold; D010456:Peptides, Cyclic; D011092:Polyethylene Glycols
keywords: Au nanorods; Hybrid nanoparticles; NIR-responsive; Photosolvolysis; Synergistic therapy