title: The Effects of Rifampin, Povidone-Iodine and Hydrogen Peroxide on the Formation of Epidural Fibrosis in the Experimental Epidural Fibrosis Model.
abstract: The aim of the study was to determine the effect of direct application of rifampin, povidone-iodine, and hydrogen peroxide on the formation of epidural fibrosis in rats. Forty-eight adult male Wistar albino rats were equally and randomly divided into four groups (laminectomy, topical rifampin, topical povidone-iodine, and topical hydrogen peroxide). Laminectomy was performed at the T12 level in all rats. Four weeks later, the extent of epidural fibrosis was assessed both macroscopically and histopathologically. ANOVA test was used for the evaluation of dural thickness. Kruskal-Wallis test was used for the pathology and macroscopic evaluation. Chi-square test was used for evaluation of the arachnoid involvement. p value <0.05 was accepted as statistically significant. Our data revealed that topical application of both povidone-iodine and hydrogen peroxide were effective in reducing epidural fibrosis formation. The results of our study provide the experimental evidence of the preventive effects of topical application of povidone-iodine and hydrogen peroxide over epidural fibrosis.
authors.affiliation: Faculty of Medicine, Adnan Menderes University, Aydin, Turkey. zahir.kizilay@adu.edu.tr.
authors.forename: Zahir
authors.initials: Z
authors.lastname: Kizilay
authors.affiliation: Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
authors.forename: Nesibe Kahraman
authors.initials: NK
authors.lastname: Cetin
authors.affiliation: Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
authors.forename: Özgur
authors.initials: Ö
authors.lastname: İsmailoglu
authors.affiliation: Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Yılmaz
authors.affiliation: Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
authors.forename: İmran Kurt
authors.initials: İK
authors.lastname: Omurlu
authors.affiliation: Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
authors.forename: Mehmet Erdal
authors.initials: ME
authors.lastname: Coskun
authors.affiliation: Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Aktaş
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004824:Epidural Space / Q000473:pathology*; D005355:Fibrosis / Q000188:drug therapy* / Q000517:prevention & control*; D006861:Hydrogen Peroxide / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012293:Rifampin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D011206:Povidone-Iodine; D006861:Hydrogen Peroxide; D012293:Rifampin
keywords: epidural space; fibrosis; hydrogen peroxide; povidone-iodine; rifampin