title: Investigation of Fucoidan-Oleic Acid Conjugate for Delivery of Curcumin and Paclitaxel.
abstract: Nanoparticles for a specific delivery are likely to be designed for cancer therapeutic effectiveness and improvement. In this study, a fucoidan-oleic acid conjugate was prepared and investigated in terms of loading capacity for poorly water-soluble anti-cancer drugs to maximize effectiveness of the treatment. Fucoidan was used as a hydrophilic portion of an amphiphilic structure for improving cancer therapeutic effects. Paclitaxel and curcumin were chosen as other model drugs loaded in the conjugates. The results showed that self-assembled nanoparticles with different sizes and morphologies could be prepared with two different concentrations of oleic acid as hydrophobic portion. Moreover, loading efficiency and release patterns of these drugs were mainly dependent on the hydrophobic interaction between drugs and oleic acid. It was also revealed that fucoidan and curcumin were released higher at pH 4.5 than at the physiological condition (pH 7.4), thus, facilitating the delivery and maximizing effects of the anticancer agents on cancer cells. On the contrary, paclitaxel from fucoidan nanoparticles was released faster at pH 7.4. The exploration of fucoidan-oleic acid conjugate could be considered as promising nanomedicines for cancer therapeutics.
authors.forename: Uyen T
authors.initials: UT
authors.lastname: Phan
authors.forename: Khanh T
authors.initials: KT
authors.lastname: Nguyen
authors.forename: Toi V
authors.initials: TV
authors.lastname: Vo
authors.forename: Wei
authors.initials: W
authors.lastname: Duan
authors.affiliation: School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria, Australia. phuong.tran1@deakin.edu.au.
authors.forename: Phuong H L
authors.initials: PH
authors.lastname: Tran
authors.affiliation: Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University-Ho Chi Minh City, Vietnam. ttdthao@hcmiu.edu.vn.
authors.forename: T D
authors.initials: TD
authors.lastname: Tran
mesh_terms: D003474:Curcumin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D050997:Nanomedicine / Q000379:methods; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D019301:Oleic Acid / Q000737:chemistry*; D017239:Paclitaxel / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011134:Polysaccharides / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D011134:Polysaccharides; D019301:Oleic Acid; C007789:fucoidan; D003474:Curcumin; D017239:Paclitaxel