title: PGC1α drives a metabolic block on prostate cancer progression.
abstract: Metabolic rewiring is essential for cancer cell survival. PGC1α, a transcriptional co-activator that is downregulated in prostate cancer, is now shown to control prostate cancer metabolism by activating an oxidative metabolic program that prevents tumour growth and metastatic dissemination.
authors.affiliation: Department of Bioengineering, University of California, San Diego, La Jolla, California, USA.
authors.forename: Martina
authors.initials: M
authors.lastname: Wallace
authors.affiliation: Department of Bioengineering, University of California, San Diego, La Jolla, California, USA.|Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.
authors.forename: Christian M
authors.initials: CM
authors.lastname: Metallo
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D051379:Mice; D009362:Neoplasm Metastasis; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000235:genetics / Q000473:pathology*; D011960:Receptors, Estrogen / Q000378:metabolism; D059467:Transcriptome / Q000235:genetics; D023041:Xenograft Model Antitumor Assays; D000097983:ERRalpha Estrogen-Related Receptor
chemical_list: D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D011960:Receptors, Estrogen; D000097983:ERRalpha Estrogen-Related Receptor