title: Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore.
abstract: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.|Department of Physics, School of Science, Tianjin University, Tianjin, 300354, P. R. China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zhang
authors.affiliation: Department of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, 518055, P. R. China.
authors.forename: Huasen
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Antaris
authors.affiliation: Palo Alto Veterans Institute for Research, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
authors.forename: Lulin
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Shuo
authors.initials: S
authors.lastname: Diao
authors.affiliation: Department of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, 518055, P. R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: Ma
authors.affiliation: Palo Alto Veterans Institute for Research, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
authors.forename: Andy
authors.initials: A
authors.lastname: Nguyen
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Guosong
authors.initials: G
authors.lastname: Hong
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Zhuoran
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Joy
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Shoujun
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Castellano
authors.affiliation: Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, CA, 94305, USA.|Center for Tissue Regeneration, Repair and Restoration, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
authors.forename: Tony
authors.initials: T
authors.lastname: Wyss-Coray
authors.affiliation: Department of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, 518055, P. R. China.
authors.forename: Yongye
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, CA, 94305, USA.|Palo Alto Veterans Institute for Research, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Dai
mesh_terms: D000818:Animals; D000070642:Brain Injuries, Traumatic / Q000000981:diagnostic imaging*; D004195:Disease Models, Animal; D005456:Fluorescent Dyes / Q000032:analysis*; D051379:Mice
chemical_list: D005456:Fluorescent Dyes
keywords: molecular fluorophores; near-infrared II fluorescence imaging; traumatic brain injury