title: The Bone Microenvironment: a Fertile Soil for Tumor Growth.
abstract: Bone metastatic disease remains a significant and frequent problem for cancer patients that can lead to increased morbidity and mortality. Unfortunately, despite decades of research, bone metastases remain incurable. Current studies have demonstrated that many properties and cell types within the bone and bone marrow microenvironment contribute to tumor-induced bone disease. Furthermore, they have pointed to the importance of understanding how tumor cells interact with their microenvironment in order to help improve both the development of new therapeutics and the prediction of response to therapy.
authors.affiliation: Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 37212, USA.|Center for Bone Biology, Vanderbilt University, 2215B Garland Avenue, 1235 MRBIV, Nashville, TN, 37232, USA.|Department of Cancer Biology, Vanderbilt University, Nashville, TN, 37232, USA.
authors.forename: Denise
authors.initials: D
authors.lastname: Buenrostro
authors.affiliation: Center for Bone Biology, Vanderbilt University, 2215B Garland Avenue, 1235 MRBIV, Nashville, TN, 37232, USA.|Department of Cancer Biology, Vanderbilt University, Nashville, TN, 37232, USA.
authors.forename: Patrick L
authors.initials: PL
authors.lastname: Mulcrone
authors.affiliation: Department of Cancer Biology, Vanderbilt University, Nashville, TN, 37232, USA.
authors.forename: Philip
authors.initials: P
authors.lastname: Owens
authors.affiliation: Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 37212, USA. julie.sterling@vanderbilt.edu.|Center for Bone Biology, Vanderbilt University, 2215B Garland Avenue, 1235 MRBIV, Nashville, TN, 37232, USA. julie.sterling@vanderbilt.edu.|Department of Cancer Biology, Vanderbilt University, Nashville, TN, 37232, USA. julie.sterling@vanderbilt.edu.|Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, 2215B Garland Avenue, 1235 MRBIV, Nashville, TN, 37232, USA. julie.sterling@vanderbilt.edu.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Sterling
mesh_terms: D001402:B-Lymphocytes; D001853:Bone Marrow / Q000098:blood supply / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology*; D001859:Bone Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000556:secondary*; D001842:Bone and Bones / Q000098:blood supply / Q000166:cytology* / Q000378:metabolism; D060833:Cellular Microenvironment; D005347:Fibroblasts; D006801:Humans; D007694:Killer Cells, Natural; D008264:Macrophages; D000072737:Myeloid-Derived Suppressor Cells; D010006:Osteoblasts; D010010:Osteoclasts; D010011:Osteocytes; D013601:T-Lymphocytes; D059016:Tumor Microenvironment
keywords: Bisphosphonates; Bone microenvironment; Immune cells; Nervous system; Tumor-induced bone disease; Vasculature