title: In vivo Raman measurement of levofloxacin lactate in blood using a nanoparticle-coated optical fiber probe.
abstract: Monitoring drug concentrations in vivo is very useful for adjusting a drug dosage during treatment and for drug research. Specifically, cutting-edge "on-line" drug research relies on knowing how drugs are metabolized or how they interact with the blood in real-time. Thus, this study explored performing in vivo Raman measurements of the model drug levofloxacin lactate in the blood using a nanoparticle-coated optical fiber probe (optical fiber nano-probe). The results show that we were able to measure real-time changes in the blood concentration of levofloxacin lactate, suggesting that this technique could be helpful for performing drug analyses and drug monitoring in a clinical setting without repeatedly withdrawing blood from patients.
authors.affiliation: Key Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China; liusp@shu.edu.cn.
authors.forename: Shupeng
authors.initials: S
authors.lastname: Liu
authors.affiliation: Key Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Rong
authors.affiliation: Key Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China; na.chen@shu.edu.cn.
authors.forename: Na
authors.initials: N
authors.lastname: Chen
authors.affiliation: Key Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China.
authors.forename: Fufei
authors.initials: F
authors.lastname: Pang
authors.affiliation: Key Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China.
authors.forename: Zhenyi
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Key Laboratory of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information, Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, China.
authors.forename: Tingyun
authors.initials: T
authors.lastname: Wang
authors.affiliation: Shanghai Institute of Immunology, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China; yanjianshe@sjtu.edu.cn.
authors.forename: Jianshe
authors.initials: J
authors.lastname: Yan
keywords: (170.1470) Blood or tissue constituent monitoring; (170.5660) Raman spectroscopy; (290.5880) Scattering, rough surfaces