title: Retinal nerve fiber layer, ganglion cell complex, and choroidal thicknesses in migraine.
abstract: OBJECTIVE
  To evaluate the thicknesses of the peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCL), and choroid layer using spectral domain optical coherence tomography (SD-OCT) for investigating the effects of vascular changes on the eye and optic nerve in patients who have migraine with aura.
  
  
  METHODS
  Forty-five patients who had migraine with aura (migraine group) and 45 healthy individuals (control group) were enrolled in the study. Age, gender, duration after migraine diagnosis, intraocular pressure, and axial length measurements were recorded in each case. RNFL, GCL, and choroid layer thicknesses were measured using SD-OCT in all participants.
  
  
  RESULTS
  The mean age was 36.1 ± 6.7 (20-45) years in the migraine group and 35.7 ± 8.6 (19-45) years in the control group. There was no significant difference in the RNFL thicknesses of the temporal and nasal quadrants (p >0.05). The RNFL thicknesses of the superior and inferior quadrants were significantly lower in the migraine group compared with those in the control group (p =0.001, p <0.01, respectively). Measurements for the superior and inferior GCL were not significantly different between the groups (p >0.05). Subfoveal, temporal, and nasal choroidal thickness measurements at 500 µm, 1000 µm, and 1500 µm were significantly lower in the migraine group than in the control group (p =0.001; p <0.01, respectively).
  
  
  CONCLUSIONS
  Compared with the controls, the RNFL and choroid layer were determined to be thinner in patients who had chronic migraine with aura.
authors.affiliation: Department of Ophthalmology, Fatih University Medical Faculty Hospital, Istanbul, Turkey.
authors.forename: Hatice Nur
authors.initials: HN
authors.lastname: Colak
authors.affiliation: Department of Ophthalmology, Fatih University Medical Faculty Hospital, Istanbul, Turkey.
authors.forename: Feride Aylin
authors.initials: FA
authors.lastname: Kantarcı
authors.affiliation: Department of Ophthalmology, Fatih University Medical Faculty Hospital, Istanbul, Turkey.
authors.forename: Mehmet Gurkan
authors.initials: MG
authors.lastname: Tatar
authors.affiliation: Department of Neurology, Fatih University Medical Faculty Hospital, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Eryilmaz
authors.affiliation: Department of Ophthalmology, Fatih University Medical Faculty Hospital, Istanbul, Turkey.
authors.forename: Hasim
authors.initials: H
authors.lastname: Uslu
authors.affiliation: Department of Ophthalmology, Fatih University Medical Faculty Hospital, Istanbul, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Goker
authors.affiliation: Department of Ophthalmology, Fatih University Medical Faculty Hospital, Istanbul, Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Yildirim
authors.affiliation: Department of Ophthalmology, Fatih University Medical Faculty Hospital, Istanbul, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Gurler
mesh_terms: D000328:Adult; D002829:Choroid / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000000981:diagnostic imaging* / Q000503:physiopathology; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000000981:diagnostic imaging / Q000503:physiopathology; D012160:Retina / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D055815:Young Adult