title: Effects of Dietary Exposure to Sulfamethazine on the Hematological Parameters and Hepatic Oxidative Stress Biomarkers in Nile Tilapia (Oreochromis niloticus).
abstract: Sulfamethazine (SMZ) is one of the most commonly used sulfonamide compounds in fish farming, and its physiological effects on fish are unknown. SMZ was administered to juvenile Nile tilapia (Oreochromis niloticus) at a dose level of 422 mg kg(-1) body weight, for a period of 11 days, via medicated feed. Fish were divided into two groups, the control group (CG) and the group fed with SMZ in feed. The administration of SMZ did not alter the erythrograms and leukograms of the Nile tilapia. The SMZ-fed group showed the same hepatic lipid peroxidation (LPO) concentration as the CG. Nonetheless, the oral administration of SMZ raised the hepatic catalase (CAT) and glutathione S-transferase (GST) activities, the increase probably being sufficient to prevent hepatic LPO production. The oral administration of SMZ affects the hepatic GST and CAT activities of Nile tilapia.
authors.affiliation: Brazilian Agricultural Research Corporation - Embrapa Environment, Ministry of Livestock and Food Supply, Rod. SP 340, km 127,5, Jaguariúna, SP, 13820-000, Brazil. fernanda.sampaio@embrapa.br.
authors.forename: Fernanda Garcia
authors.initials: FG
authors.lastname: Sampaio
authors.affiliation: Environmental Engineering, Faculty of Jaguariúna, Jaguariúna, SP, Brazil.
authors.forename: Maria Lídia
authors.initials: ML
authors.lastname: Carra
authors.affiliation: Brazilian Agricultural Research Corporation - Embrapa Environment, Ministry of Livestock and Food Supply, Rod. SP 340, km 127,5, Jaguariúna, SP, 13820-000, Brazil.
authors.forename: Claudio Martin
authors.initials: CM
authors.lastname: Jonsson
authors.affiliation: Environmental Engineering, Faculty of Jaguariúna, Jaguariúna, SP, Brazil.
authors.forename: Vitoria Teodoro
authors.initials: VT
authors.lastname: Gonçalves
authors.affiliation: Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
authors.forename: Genoefa
authors.initials: G
authors.lastname: Dal'Bo
authors.affiliation: University of Campinas, Campinas, SP, Brazil.
authors.forename: Kátia Santos Damacena
authors.initials: KS
authors.lastname: Nunes
authors.affiliation: Brazilian Agricultural Research Corporation - Embrapa Environment, Ministry of Livestock and Food Supply, Rod. SP 340, km 127,5, Jaguariúna, SP, 13820-000, Brazil.
authors.forename: José Henrique
authors.initials: JH
authors.lastname: Valim
authors.affiliation: Laboratory of Animal Welfare and Avian Pathology, Faculty of Agronomy and Veterinary Medicine, University of Brasília, Brasília, DF, Brazil.
authors.forename: Bruno Stéfano Lima
authors.initials: BS
authors.lastname: Dallago
authors.affiliation: Brazilian Agricultural Research Corporation - Embrapa Environment, Ministry of Livestock and Food Supply, Rod. SP 340, km 127,5, Jaguariúna, SP, 13820-000, Brazil.
authors.forename: Sonia Claudia
authors.initials: SC
authors.lastname: do Nascimento de Queiroz
authors.affiliation: Food Toxicology at School of Food Engineering, University of Campinas, Campinas, SP, Brazil.
authors.forename: Felix Guillermo Reyes
authors.initials: FG
authors.lastname: Reyes
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity; D015415:Biomarkers / Q000378:metabolism; D001772:Blood Cell Count; D002374:Catalase / Q000378:metabolism; D023681:Cichlids / Q000378:metabolism*; D004032:Diet; D005982:Glutathione Transferase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D013418:Sulfamethazine / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D000890:Anti-Infective Agents; D015415:Biomarkers; D013418:Sulfamethazine; D002374:Catalase; D005982:Glutathione Transferase
keywords: Antibiotics; Antioxidant defense; Sulfamethazine; Toxicology