title: Spicy science: David Julius and the discovery of temperature-sensitive TRP channels.
abstract: This invited biographical review covers the career of Dr. David Julius and his discovery of thermosensitive TRP channels. Dr. Julius is currently the Morris Herzstein Chair in Molecular Biology and Medicine and Professor and Chair of Physiology at the University of California, San Francisco Medical School. He is a member of the National Academy of Sciences and has received many distinguished awards for his landmark discoveries of the molecular basis of pain and thermosensation.
authors.affiliation: Department of Molecular & Cell Biology and Helen Wills Neuroscience Institute; University of California Berkeley ; Berkeley, CA, USA.
authors.forename: Diana M
authors.initials: DM
authors.lastname: Bautista
keywords: 5-HT3 (also HTR3), 5-Hydroxytryptamine (Serotonin) Receptor 3; DRG, dorsal root ganglia; GABAB, Gamma-Aminobutyric Acid (GABA) B Receptor; GPCR, G protein-coupled receptor; P2X, Purinergic Receptor P2X; TRP channel; TRP, transient receptor potential; TRPA1, transient receptor potential cation channel, subfamily A, member 1; TRPM8, transient receptor potential cation channel, subfamily M, member 8; TRPV1, transient receptor potential cation channel, subfamily V, member 1; pain; sensory neuron; somatosensation; thermosensation; α-MSH, α-melanocyte stimulating hormone