title: Regulation of hematopoietic development by ZBTB transcription factors.
abstract: Hematopoietic development is governed by the coordinated expression of lineage- and differentiation stage-specific genes. Transcription factors play major roles in this process and their perturbation may underlie hematologic and immunologic disorders. Nearly 1900 transcription factors are encoded in the human genome: of these, 49 BTB (for broad-complex, tram-track and bric à brac)-zinc finger transcription factors referred to as ZBTB or POK proteins have been identified. ZBTB proteins, including BCL6, PLZF, ThPOK and LRF, exhibit a broad spectrum of functions in normal and malignant hematopoiesis. This review summarizes developmental and molecular functions of ZBTB proteins relevant to hematology.
authors.affiliation: Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA, 02115, USA. tmaeda@partners.org.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Maeda
mesh_terms: D006402:Hematologic Diseases / Q000235:genetics; D006410:Hematopoiesis / Q000235:genetics*; D006801:Humans; D012097:Repressor Proteins; D014157:Transcription Factors / Q000378:metabolism*; D016335:Zinc Fingers
chemical_list: D012097:Repressor Proteins; D014157:Transcription Factors; C570228:ZBTB1 protein, human
keywords: Co-repressor; Hematopoiesis; Transcription factor