title: A Case of Organizing Pneumonia (OP) Associated with Pembrolizumab.
abstract: Until recently, chemotherapy for metastatic melanoma had disappointing results. The identification of immune checkpoints such as CTLA-4 and PD-1/PD-L1 has led to the development of an array of monoclonal antibodies (Mabs). These immunologic approaches against tumoral cells come with a novel kind of side effects that the clinician needs to be familiarized with. Herein, we report for the first time a case of organizing pneumonia, based on imaging and cytological analyses of bronchoalveolar lavage, possibly associated with the use of pembrolizumab, an anti-PD-1 Mab recently approved for the treatment of metastatic melanoma.
authors.affiliation: Fourth Department of Internal Medicine, Infectious Diseases Unit, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Fragkou
authors.affiliation: Fourth Department of Internal Medicine, Infectious Diseases Unit, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Souli
authors.affiliation: Fourth Department of Internal Medicine, Hematology-Oncology Unit, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Theochari
authors.affiliation: 2nd Radiology Department, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Kontopoulou
authors.affiliation: 2nd Respiratory Medicine Department, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Stelios
authors.initials: S
authors.lastname: Loukides
authors.affiliation: Fourth Department of Internal Medicine, Hematology-Oncology Unit, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Anna
authors.initials: A
authors.lastname: Koumarianou
keywords: OP; melanoma; organizing pneumonia; pembrolizumab; side effect