title: Clinical significance and new detection system of autoantibodies in myositis with interstitial lung disease.
abstract: Anti-aminoacyl-tRNA synthetase (ARS) and anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are closely associated with interstitial lung disease in polymyositis and dermatomyositis. Anti-ARS-positive patients develop common clinical characteristics termed anti-synthetase syndrome and share a common clinical course, in which they respond well to initial treatment with glucocorticoids but in which disease tends to recur when glucocorticoids are tapered. Anti-MDA5 antibody is associated with rapidly progressive interstitial lung disease and poor prognosis, particularly in Asia. Therefore, intensive immunosuppressive therapy is required for anti-MDA5-positive patients from the early phase of the disease. New enzyme-linked immunosorbent assays to detect anti-ARS and anti-MDA5 antibodies have recently been established and are suggested to be efficient and useful. These assays are expected to be widely applied in daily practice.
authors.affiliation: Department of Rheumatology and Clinical Immunology, Kyoto University, Kyoto, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Nakashima
authors.affiliation: Department of Rheumatology and Clinical Immunology, Kyoto University, Kyoto, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hosono
authors.affiliation: Department of Rheumatology and Clinical Immunology, Kyoto University, Kyoto, Japan mimorit@kuhp.kyoto-u.ac.jp.
authors.forename: T
authors.initials: T
authors.lastname: Mimori
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003882:Dermatomyositis / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D006801:Humans; D000072640:Interferon-Induced Helicase, IFIH1 / Q000276:immunology*; D017563:Lung Diseases, Interstitial / Q000150:complications*
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; C452815:IFIH1 protein, human; D000072640:Interferon-Induced Helicase, IFIH1; D000604:Amino Acyl-tRNA Synthetases
keywords: Polymyositis; anti-MDA5 antibody; anti-aminoacyl tRNA synthetase antibody; anti-synthetase syndrome; clinically amyopathic dermatomyositis; dermatomyositis; enzyme-linked immunosorbent assay; ferritin; high resolution computed tomography; interstitial lung disease