title: [Effect of Qingfei Quyu Decoction in Prevention of Radiation Pneumonitis Induced by Concurrent Chemoradiotherapy for Esophageal Carcinoma Patients].
abstract: OBJECTIVE
  To assess the effect of Qingfei Quyu Decoction (QQD) in preventing radiation pneumonitis in esophageal carcinoma patients by concurrent using it with chemoradiotherapy.
  
  
  METHODS
  A total of 120 patients with mid-late stage esophageal carcinoma were randomly assigned to the treatment group (60 cases) and the control group (60 cases). All patients received concurrent radiochemotherapy. Patients in the treatment group additionally took QQD, one dose per day for 8 successive weeks. The incidence of radiation pneunonitis was compared between the two groups. The improvement rates of short-term benefit rate, Karnofsky performance scale (KPS), and body weight (BW) improvement rate were calculated between the two groups. The 1-and 2-year overall survival rates were compared between the two groups.
  
  
  RESULTS
  The incidence of radiation pneunonitis was 8.93% (15/56) in the treatment group and 18.64% (11/59) in the control group (P < 0.05). The short-term benefit rate was 92.86% (52/56) in the treatment group and 69.49% (41/59) in the control group (P < 0.05). Besides, the KPS and BW improvement rate were higher in the treatment group [89.29% (50/56) and 83.05% (49/59) ] than in the control group [80.36% (45/56) and 66.10% (39/59)] (P < 0.05). The 1-and 2-year overall survival rate were 66.07% and 35.71% in the treatment group, higher than those of the control group (61.02% and 30.51%; P > 0.05).
  
  
  CONCLUSIONS
  Concurrent using QQD with chemoradiotherapy for treating esophageal carcinoma patients could lower the incidence of radiation pneumonitis, attenuate the degree of radiation induced lung injury, improve clinical benefit rate, and elevate their QOL.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cui
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Yin
authors.forename: Duo-jie
authors.initials: DJ
authors.lastname: Li
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Liu
authors.forename: Xue-ming
authors.initials: XM
authors.lastname: Shen
authors.forename: Kai-gui
authors.initials: KG
authors.lastname: Peng
authors.forename: Hao
authors.initials: H
authors.lastname: Jiang
mesh_terms: D002294:Carcinoma, Squamous Cell; D059248:Chemoradiotherapy / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D017564:Radiation Pneumonitis / Q000517:prevention & control*; D015996:Survival Rate
chemical_list: D004365:Drugs, Chinese Herbal