title: Cardiac Function and Dysfunction in Sepsis.
abstract: Cardiac function and dysfunction are important in the clinical outcomes of sepsis and septic shock. Cardiac dysfunction is not a single entity, but is a broad spectrum of syndromes that result in biventricular cardiac dysfunction manifested by both systolic and diastolic dysfunction and is influenced by cardiac loading conditions (ie, preload and afterload). Elucidating the underlying pathophysiology has proved to be complex. This article emphasizes the underlying pathophysiology of cardiac dysfunction and explores recent evidence related to diagnosis, including the utility of biomarkers, the role of echocardiography, and management goals and treatment.
authors.affiliation: Department of Pediatrics, Stony Brook University School of Medicine, Stony Brook, NY 11794-8111, USA. Electronic address: kimberly.fenton@stonybrookmedicine.edu.
authors.forename: Kimberly E
authors.initials: KE
authors.lastname: Fenton
authors.affiliation: Department of Pediatrics, Stony Brook University School of Medicine, Stony Brook, NY 11794-8111, USA.
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Parker
mesh_terms: D004452:Echocardiography / Q000379:methods*; D006331:Heart Diseases / Q000209:etiology*; D006439:Hemodynamics; D006801:Humans; D011446:Prospective Studies; D018805:Sepsis / Q000150:complications*
keywords: Cardiac dysfunction; Echocardiography; Hemodynamics; Sepsis; Troponin; Ventricular function