title: Should High-Frequency Ventilation in the Adult Be Abandoned?
abstract: High-frequency oscillatory ventilation (HFOV) can improve ventilation-perfusion matching without excessive alveolar tidal stretching or collapse-reopening phenomenon. This is an attractive feature in the ventilation of patients with ARDS. However, two recent large multi-center trials of HFOV failed to show benefits in this patient population. The following review addresses whether, in view of these trails, HFOV should be abandoned in the adult population?
authors.affiliation: Department of Anesthesiology, University of California, San Diego, California.
authors.forename: Albert P
authors.initials: AP
authors.lastname: Nguyen
authors.affiliation: Department of Anesthesiology, University of California, San Diego, California. uschmidt@ucsd.edu.
authors.forename: Ulrich H
authors.initials: UH
authors.lastname: Schmidt
authors.affiliation: Department of Medicine, Duke University, Durham, North Carolina.
authors.forename: Neil R
authors.initials: NR
authors.lastname: MacIntyre
mesh_terms: D000328:Adult; D000818:Animals; D006612:High-Frequency Ventilation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008168:Lung / Q000503:physiopathology; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*; D012129:Respiratory Function Tests
keywords: acute respiratory failure; high-frequency oscillatory ventilation