title: D-Peptides as Recognition Molecules and Therapeutic Agents.
abstract: Over recent years, D-peptides have attracted increasing attention. D-peptides increase enzymatic stability, prolong the plasma half-life, improve oral bioavailability, and enhance binding activity and specificity with receptor or target proteins, in comparison with the corresponding L-peptide. Therefore, D-peptides are considered to have potential as recognition molecules and therapeutic agents. This review focuses on the design and application of D-peptides with biological activity.
authors.affiliation: Key Laboratory of Smart Drug Delivery (Fudan University)Ministry of Education Department of Pharmaceutics School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (P. R. China).
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: Key Laboratory of Smart Drug Delivery (Fudan University)Ministry of Education Department of Pharmaceutics School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (P. R. China).
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.affiliation: Key Laboratory of Smart Drug Delivery (Fudan University)Ministry of Education Department of Pharmaceutics School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (P. R. China).
authors.forename: Zuoxu
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Key Laboratory of Smart Drug Delivery (Fudan University)Ministry of Education Department of Pharmaceutics School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (P. R. China).
authors.forename: Cao
authors.initials: C
authors.lastname: Xie
authors.affiliation: Key Laboratory of Smart Drug Delivery (Fudan University)Ministry of Education Department of Pharmaceutics School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (P. R. China).|Department of Pharmacology School of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Shanghai 200032 (P. R. China).
authors.forename: Changyou
authors.initials: C
authors.lastname: Zhan
authors.affiliation: Key Laboratory of Smart Drug Delivery (Fudan University)Ministry of Education Department of Pharmaceutics School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (P. R. China).
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Hu
authors.affiliation: Key Laboratory of Smart Drug Delivery (Fudan University)Ministry of Education Department of Pharmaceutics School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (P. R. China).
authors.forename: Qing
authors.initials: Q
authors.lastname: Shen
authors.affiliation: Key Laboratory of Smart Drug Delivery (Fudan University)Ministry of Education Department of Pharmaceutics School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (P. R. China).
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wei
authors.affiliation: Key Laboratory of Smart Drug Delivery (Fudan University)Ministry of Education Department of Pharmaceutics School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (P. R. China).
authors.forename: Bingxia
authors.initials: B
authors.lastname: Su
authors.affiliation: Key Laboratory of Smart Drug Delivery (Fudan University)Ministry of Education Department of Pharmaceutics School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (P. R. China).
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Smart Drug Delivery (Fudan University)Ministry of Education Department of Pharmaceutics School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203 (P. R. China).
authors.forename: Weiyue
authors.initials: W
authors.lastname: Lu
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000378:metabolism; D045744:Cell Line, Tumor; D015195:Drug Design; D023581:HIV Fusion Inhibitors / Q000494:pharmacology; D006801:Humans; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000378:metabolism; D039942:Neuropilin-1 / Q000378:metabolism; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D011978:Receptors, Nicotinic / Q000378:metabolism; D011990:Receptors, Transferrin / Q000378:metabolism; D013237:Stereoisomerism; D022223:Vaccines, Subunit
chemical_list: D000970:Antineoplastic Agents; D023581:HIV Fusion Inhibitors; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D010455:Peptides; D011978:Receptors, Nicotinic; D011990:Receptors, Transferrin; D022223:Vaccines, Subunit; D039942:Neuropilin-1
keywords: mirror-image phage display; molecular recognition; peptides; retro-inverso