title: Synthesis, biocompatibility and mechanical properties of ZrO2-Al2O3 ceramics composites.
abstract: This study evaluated cell viability, microhardness and flexural strength of two ceramic composites systems (ZA and AZ), pure alumina and zirconia. There were prepared homogeneous mixtures of 78wt%Al2O3+20wt%3Y-TZP+2wt%Al2O3w (AZ) and 80wt%3YTZP+18wt%Al2O3+2wt%Al2O3w (ZA), as well as 3Y-TZP (Z), pure Al2O3 (A) and commercial monolithic 3Y-TZP (Zc). Also mouse fibroblast cells 3T3-L1 and a MTT test was carried out at 24, 48 and 72 h. The surfaces were observed with SEM and the microhardness and three-point flexural strength values were estimated. The absolute microhardness values were: A>AZ>Z>Zc>ZA. Flexural strength of Zc, Z, and ZA were around double than AZ and A. All groups showed high biocompatibility trough cell viability values at 24, 48 and 72 h. Factors like grain shape, grain size and homogeneous or heterogeneous grain distributions may play an important role in physical, mechanical and biological properties of the ceramic composites.
authors.affiliation: Department of Research, Faculty of Dentistry, Autonomouos University of Chihuahua.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Nevarez-Rascon
authors.forename: Santiago
authors.initials: S
authors.lastname: González-Lopez
authors.forename: Laura Susana
authors.initials: LS
authors.lastname: Acosta-Torres
authors.forename: Martina Margarita
authors.initials: MM
authors.lastname: Nevarez-Rascon
authors.forename: Erasmo
authors.initials: E
authors.lastname: Orrantia-Borunda
mesh_terms: D000537:Aluminum Oxide; D000818:Animals; D002516:Ceramics; D005347:Fibroblasts; D008422:Materials Testing; D051379:Mice; D015040:Zirconium
chemical_list: D015040:Zirconium; D000537:Aluminum Oxide