title: Long non-coding RNA: Functional agent for disease traits.
abstract: In recent years, long non-coding RNAs (lncRNAs) have attracted the attention of researchers with their involvement in all facets of life. LncRNAs are transcripts of more than 200 nucleotides which lack defined protein coding potential. Although they do not code for proteins, a large number of them are involved in regulating gene expression and translation. The presence of numerous lncRNAs in the human genome has prompted us to investigate the contribution of these molecules to human biology and medicine. In this review, we present the potential role of lncRNAs interlinked to different human diseases and genetic disorders. We also describe their role in cellular differentiation and aging and discuss their potential importance as biomarkers and as therapeutic agents.
authors.affiliation: a Functional Genomics and Gene Silencing Group , CSIR- Center for Cellular and Molecular Biology , Hyderabad , India.
authors.forename: Sriyans
authors.initials: S
authors.lastname: Jain
authors.affiliation: a Functional Genomics and Gene Silencing Group , CSIR- Center for Cellular and Molecular Biology , Hyderabad , India.
authors.forename: Nirav
authors.initials: N
authors.lastname: Thakkar
authors.affiliation: a Functional Genomics and Gene Silencing Group , CSIR- Center for Cellular and Molecular Biology , Hyderabad , India.
authors.forename: Jagamohan
authors.initials: J
authors.lastname: Chhatai
authors.affiliation: b Centre for Chemical Biology , Indian Institute for Chemical Technology , Hyderabad , India.
authors.forename: Manika
authors.initials: M
authors.lastname: Pal Bhadra
authors.affiliation: a Functional Genomics and Gene Silencing Group , CSIR- Center for Cellular and Molecular Biology , Hyderabad , India.
authors.forename: Utpal
authors.initials: U
authors.lastname: Bhadra
mesh_terms: D000375:Aging; D000818:Animals; D017209:Apoptosis; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation; D004702:Endocrine Glands / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007109:Immunity / Q000502:physiology; D051379:Mice; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D009422:Nervous System Diseases / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism*; D051381:Rats
chemical_list: D015415:Biomarkers; D062085:RNA, Long Noncoding
keywords: Biomarkers; epigenetics; gene regulation; human diseases; long non-coding RNA; therapeutic agents