title: Screening and Testing in Multiples.
abstract: The choice of screening or invasive procedure in twin pregnancies is a personal choice of whether the patient wishes to take a small risk of having a baby with a serious disorder versus a small risk of having a complication because she wishes to avoid that. How to interpret such risks has profound effects on the perceived value of techniques, either leading to a decision to screening or going directly to chorionic villus sampling. There are profound issues surrounding the data and the interpretation of the data. No single short review can exhaustively examine all of the issues.
authors.affiliation: Fetal Medicine Foundation of America, USA; Comprehensive Genetics, 131 East 65th Street, New York, NY 10065, USA; Mt. Sinai School of Medicine, New York, NY, USA. Electronic address: evans@compregen.com.
authors.forename: Mark I
authors.initials: MI
authors.lastname: Evans
authors.affiliation: Fetal Medicine Foundation of America, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Andriole
authors.affiliation: Comprehensive Genetics, 131 East 65th Street, New York, NY 10065, USA; University of Colorado, Aurora, CO, USA.
authors.forename: Shara M
authors.initials: SM
authors.lastname: Evans
mesh_terms: D004247:DNA / Q000097:blood; D005260:Female; D005817:Genetic Counseling; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D011247:Pregnancy; D018607:Pregnancy Reduction, Multifetal; D011272:Pregnancy, Multiple / Q000235:genetics*; D011296:Prenatal Diagnosis / Q000009:adverse effects / Q000379:methods*; D012307:Risk Factors
chemical_list: D004247:DNA
keywords: Amniocentesis; CVS; Cell-free fetal DNA; Fetal reduction; Free β-hCG; Multiple pregnancy risks; Prenatal screening