title: Chronic behavior disturbance and neurocognitive deficits in neuro-Behcet's disease: a case study.
abstract: Behcet's disease is a vasculitis and multisystem inflammatory syndrome. Neurological abnormalities occur in a subset of patients. This report presents a case of neuro-Behcet's disease characterized by an initial onset of behavior changes prior to diagnosis, which evolved into a chronic behavioral syndrome. Neuroimaging investigations revealed progressive periventricular white matter and brainstem atrophy and lesions in the basal ganglia and deep white matter tracts, while neuropsychological investigations revealed reductions in information processing, executive functioning, and memory. The case indicates that behavior changes may be the first symptoms to emerge in Behcet's, before other defining features of the disease.
authors.affiliation: a Brain Disorders Program , Austin Health , Melbourne , Australia.|b The Melbourne Clinic , Melbourne , Australia.|c Psychology Department , Royal Melbourne Hospital , Melbourne , Australia.
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Fisher
authors.affiliation: a Brain Disorders Program , Austin Health , Melbourne , Australia.
authors.forename: Katherine
authors.initials: K
authors.lastname: Sewell
authors.affiliation: d Department of Radiology , Austin Health , Melbourne , Australia.
authors.forename: Amy
authors.initials: A
authors.lastname: Baker
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000473:pathology*; D001526:Behavioral Symptoms / Q000209:etiology*; D001528:Behcet Syndrome / Q000150:complications* / Q000473:pathology; D001933:Brain Stem / Q000000981:diagnostic imaging / Q000473:pathology*; D060825:Cognitive Dysfunction / Q000209:etiology*; D006801:Humans; D008297:Male; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology*
keywords: Bechet’s syndrome; Behcet disease; behavior; neuroimaging; neuropsychology