title: Magnetic targeted drug delivery carriers encapsulated with pH-sensitive polymer: synthesis, characterization and in vitro doxorubicin release studies.
abstract: Targeted and efficient delivery of drug to tumor is one of the crucial issues in cancer therapy. In this work, we have successfully designed and prepared the pH-sensitive magnetic nanoparticles (MNPs) as targeted anticancer drug carriers, in which the MNPs were coated by poly(acrylic acid) (PAA) and the obtained PAA@MNPs exhibited a size within 100 nm, good stability, and superparamagnetic responsibility (Ms 45.97 emu/g). Doxorubicin (DOX) can be successfully loaded onto MNPs via electrostatic interaction, and the drug loading content and loading efficiency are 26.4 and 88.1%, respectively. Moreover, the release studies showed that the drug-loaded carriers (MNPs-DOX) had excellent pH sensitivity, 75.6% of the loaded DOX was released at pH 4.0 within 48 h. Importantly, MTT assays in HUVEC and MCF-7 cells demonstrated that MNPs-DOX exhibited high anti-tumor activity, while the PAA@MNPs were practically nontoxic. Thus, our results revealed that PAA@MNPs would be a competitive candidate for biomedical application and MNPs-DOX could be used in targeted cancer therapy.
authors.affiliation: a National Special Superfine Powder Engineering Research Center , Nanjing University of Science and Technology , Nanjing , China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wu
authors.affiliation: a National Special Superfine Powder Engineering Research Center , Nanjing University of Science and Technology , Nanjing , China.
authors.forename: Yueqing
authors.initials: Y
authors.lastname: Shen
authors.affiliation: a National Special Superfine Powder Engineering Research Center , Nanjing University of Science and Technology , Nanjing , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.affiliation: a National Special Superfine Powder Engineering Research Center , Nanjing University of Science and Technology , Nanjing , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.affiliation: a National Special Superfine Powder Engineering Research Center , Nanjing University of Science and Technology , Nanjing , China.
authors.forename: Yewen
authors.initials: Y
authors.lastname: Shen
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival; D004317:Doxorubicin / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers; D065546:Drug Liberation; D005079:Excipients; D006801:Humans; D006863:Hydrogen-Ion Concentration; D061986:MCF-7 Cells; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D055672:Static Electricity; D013499:Surface Properties
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D004337:Drug Carriers; D005079:Excipients; D058185:Magnetite Nanoparticles; C006903:carbopol 940; D004317:Doxorubicin
keywords: Fe3O4 nanoparticles; doxorubicin; drug release; pH-sensitive; poly(acrylic acid)