title: Mycobacterium chelonae Scleral Abscess After Intravitreal Ranibizumab Injection.
abstract: OBJECTIVE
  To report a case of Mycobacterium chelonae scleral abscess after an intravitreal injection of ranibizumab.
  
  
  METHODS
  A 54-year-old female received an intravitreal ranibizumab injection for diabetic macular edema. Two weeks postinjection, a scleral abscess developed at the injection site. The patient was treated with incision and drainage of the abscess, subconjunctival injection of amikacin, topical clarithromycin and amikacin, and oral clarithromycin.
  
  
  RESULTS
  After 4 weeks of treatment, the inflammation and infection resolved, and the patient returned to best-corrected preinjection visual acuity.
  
  
  CONCLUSIONS
  Injection-site scleral abscesses are very rare and serious complications of intravitreal injections. Once the abscess is drained, it is possible to identify the organism and treat the infection with appropriate combination antibiotic therapy.
authors.affiliation: Dean McGee Eye Institute, Oklahoma City, OK.
authors.forename: Ilya M
authors.initials: IM
authors.lastname: Sluch
authors.forename: Rhea L
authors.initials: RL
authors.lastname: Siatkowski
authors.forename: Vinay A
authors.initials: VA
authors.lastname: Shah
mesh_terms: D000038:Abscess / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D000583:Amikacin / Q000627:therapeutic use; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017291:Clarithromycin / Q000627:therapeutic use; D003930:Diabetic Retinopathy / Q000188:drug therapy; D004359:Drug Therapy, Combination; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D058449:Intravitreal Injections / Q000009:adverse effects*; D008269:Macular Edema / Q000188:drug therapy; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D016926:Mycobacterium chelonae / Q000302:isolation & purification*; D000069579:Ranibizumab / Q000008:administration & dosage*; D015422:Scleral Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors
chemical_list: D020533:Angiogenesis Inhibitors; D000900:Anti-Bacterial Agents; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000583:Amikacin; D017291:Clarithromycin; D000069579:Ranibizumab