title: Piecing Together the Adrenal Cancer Puzzle.
abstract: Through an international collaboration, researchers have produced an extensive characterization of adrenocortical carcinoma, a rare endocrine cancer with limited treatment options. They found that the disease has three DNA methylation-driven subtypes with distinct clinical outcomes, and is prone to genomic instability.
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D018268:Adrenocortical Carcinoma; D019175:DNA Methylation; D042822:Genomic Instability; D006801:Humans