title: Association of ideal cardiovascular health metrics and cognitive functioning: the APAC study.
abstract: Previous studies have demonstrated that the components of ideal cardiovascular health (CVH) metrics are related to dementia. This study aimed to investigate the overall effects of ideal CVH metrics on cognitive functioning.
  
  
  
  Information was collected on the seven ideal CVH metrics (smoking, body mass index, dietary intake, physical activity, blood pressure, total cholesterol and fasting blood glucose) from the Asymptomatic Polyvascular Abnormalities Community study, and cognitive functioning was assessed by the score of the Mini-Mental State Examination (MMSE). Multivariate logistic regression and linear regression models were used to assess the relationships between ideal CVH metrics and cognitive functioning.
  
  
  
  A total of 3260 (56.7% men) patients were included in this study. After adjusting for potential confounding factors, the associations between the number or score of ideal CVH metrics and cognitive impairment remained significant [odds ratio (OR) (95% confidence interval) 0.773 (0.664-0.928) and 0.904 (0.831-0.983), respectively]. In addition, there were significant linear relationships between the number or score of CVH metrics and the score of the MMSE (β = 0.211 and 0.134 respectively, P < 0.001).
  
  
  
  A clear inverse association was observed between the number or score of ideal CVH metrics and cognitive impairment in a Chinese population, supporting the importance of ideal CVH metrics in prevention of dementia.
authors.affiliation: Department of Neuropsychological and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
authors.forename: N
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Graduate School, North China University of Science and Technology, Tangshan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.|Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.|Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
authors.forename: A
authors.initials: A
authors.lastname: Wang
authors.affiliation: Departments of Neurology, Tangshan Gongren Hospital, Tangshan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Neuropsychological and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Neuropsychological and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Departments of Neurosurgery, Tangshan Gongren Hospital, Tangshan, China.
authors.forename: K
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Neuropsychological and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Neuropsychological and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
authors.forename: S
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Neuropsychological and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Neuropsychological and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: M
authors.initials: M
authors.lastname: Zhu
authors.affiliation: Department of Neuropsychological and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China.
authors.forename: S
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Neuropsychological and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.|Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.|Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D002318:Cardiovascular Diseases / Q000503:physiopathology; D002320:Cardiovascular Physiological Phenomena; D002681:China / Q000453:epidemiology; D003071:Cognition / Q000502:physiology*; D003430:Cross-Sectional Studies; D056344:Executive Function; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008297:Male; D000073216:Mental Status and Dementia Tests; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012959:Socioeconomic Factors
keywords: Mini-Mental State Examination; cognitive functioning; ideal cardiovascular health metrics