title: The interaction of cultural consonance and a polymorphism in the 2A serotonin receptor in relation to depression in Brazil: failure to replicate previous findings.
abstract: To replicate a previously identified gene-environment interaction between a genetic polymorphism in the serotonin 2A receptor and cultural consonance in family life in relation to depressive symptoms (Dressler et al., 2009).
  
  
  
  A sample of 402 individuals in a sample drawn from four different economic strata in Ribeirão Preto, Brazil was interviewed and genotyped.
  
  
  
  Cultural consonance in family life has an inverse association with depressive symptoms (beta = -0.439, P < 0.001) and with high depressive symptoms (OR = 2.36, P < 0.001), but the interaction with genotype was not statistically significant.
  
  
  
  The previously identified gene-environment interaction was not replicated. Limitations of the study are discussed. Am. J. Hum. Biol. 28:936-940, 2016. © 2016Wiley Periodicals, Inc.
authors.affiliation: Department of Anthropology, The University of Alabama, Tuscaloosa, Alabama, USA.
authors.forename: William W
authors.initials: WW
authors.lastname: Dressler
authors.affiliation: Department of Psychology, Paulista University, Ribeirão Preto, São Paulo, Brazil.
authors.forename: Mauro C
authors.initials: MC
authors.lastname: Balieiro
authors.affiliation: Department of Genetics, Ribeirao Preto Medical School University of Sao Paulo-Ribeirao Preto, and Center for Medical Genomics at HCFMRP/USP, Ribeirão Preto, São Paulo, Brazil.
authors.forename: Luiza Ferreira
authors.initials: LF
authors.lastname: de Araújo
authors.affiliation: Department of Genetics, Ribeirao Preto Medical School University of Sao Paulo-Ribeirao Preto, and Center for Medical Genomics at HCFMRP/USP, Ribeirão Preto, São Paulo, Brazil.
authors.forename: Wilson A
authors.initials: WA
authors.lastname: Silva
authors.affiliation: Department of Internal Medicine, University of São Paulo-Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil.
authors.forename: José Ernesto
authors.initials: JE
authors.lastname: Dos Santos
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D003863:Depression / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012931:Social Environment
chemical_list: D044402:Receptor, Serotonin, 5-HT2A