title: Predictive Role of Serum Tumor Markers in Diagnosis of Pulmonary Tuberculosis.
abstract: BACKGROUND
  The diagnosis of pulmonary tuberculosis (PTB) is complicated and time-consuming currently. There was association of PTB with serum tumor markers. In this study we aimed to evaluate the predictive role of serum CA125, CA199 and CEA as diagnostic tools for PTB.
  
  
  METHODS
  This study was designed as a case-control study with 565 subjects who visited the Yijishan Hospital from Jun to Dec in 2014.This case-control study matched as for age and sex with 113 cases and 452 controls. Serum CA125, CA199 and CEA levels were detected by electrochemiluminescence instrument. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve was performed to evaluate the diagnostic value on PTB.
  
  
  RESULTS
  Serum levels of CA125, CA199 and CEA in PTB patients were significantly higher than those in control group (P<0.001). There was no significantly different of three tumor markers between initial treatment group and retreatment group. The logistic regression analysis showed that CA125 was an impact factor to PTB. The ROC analysis revealed that AUC of CA125 was 0.966 (95%CI: 0.951-0.981), the sensitivity, specificity in serum and cut-off were 95.6%, 85.0% and 10.30 U/ml, respectively.
  
  
  CONCLUSIONS
  The serum CA125 has potential good diagnostic performance for PTB.
authors.affiliation: Dept. of Preventive Medicine, School of Public Health, Wannan Medical College, Wuhu City, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Ma
authors.affiliation: Dept. of Preventive Medicine, School of Public Health, Wannan Medical College, Wuhu City, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Xia
authors.affiliation: Dept. of Preventive Medicine, School of Public Health, Wannan Medical College, Wuhu City, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.affiliation: Dept. of Preventive Medicine, School of Public Health, Wannan Medical College, Wuhu City, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Fu
authors.affiliation: Dept. of Preventive Medicine, School of Public Health, Wannan Medical College, Wuhu City, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Xu
authors.affiliation: Dept. of Preventive Medicine, School of Public Health, Wannan Medical College, Wuhu City, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Dept. of Preventive Medicine, School of Public Health, Wannan Medical College, Wuhu City, China.
authors.forename: Mengying
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Dept. of Preventive Medicine, School of Public Health, Wannan Medical College, Wuhu City, China.
authors.forename: Benhe
authors.initials: B
authors.lastname: Li
authors.affiliation: Dept. of Infectious Diseases, Yijishan Hospital, Wuhu City, China.
authors.forename: Jianghua
authors.initials: J
authors.lastname: Yang
authors.affiliation: Dept. of Preventive Medicine, School of Public Health, Wannan Medical College, Wuhu City, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Wen
keywords: CA125; CA199; CEA; Characteristic curve; Pulmonary tuberculosis; Receiver-operating