title: Acute hemolysis in a patient with a newly diagnosed glioblastoma.
abstract: We describe a 62-year-old of Egyptian origin who presented with sudden, severe and symptomatic anemia requiring hospitalization shortly after beginning concurrent radiation and temozolomide for his newly diagnosed glioblastoma. He had also recently been started on steroids, anticonvulsants and Pneumocystis jirovecii prophylaxis. He was ultimately diagnosed with G6PD deficiency with an acute hemolytic anemia precipitated by dapsone. Screening for G6PD deficiency should be considered in high-risk patient populations where P. jirovecii prophylaxis is planned.
authors.affiliation: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors.forename: Adrian G
authors.initials: AG
authors.lastname: Murphy
authors.affiliation: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Grossman
mesh_terms: D000743:Anemia, Hemolytic / Q000150:complications*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000150:complications* / Q000188:drug therapy; D003907:Dexamethasone / Q000627:therapeutic use; D005909:Glioblastoma / Q000150:complications* / Q000188:drug therapy; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications* / Q000188:drug therapy; D006461:Hemolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D018931:Antineoplastic Agents, Hormonal; D003907:Dexamethasone
keywords: dapsone; glioblastoma multiforme; glucose-6-phosphate dehydrogenase deficiency (G6PD); hemolytic anemia