title: Chronic Bacterial Pathogens: Mechanisms of Persistence.
abstract: Many bacterial pathogens can cause acute infections that are cleared with the onset of adaptive immunity, but a subset of these pathogens can establish persistent, and sometimes lifelong, infections. While bacteria that cause chronic infections are phylogenetically diverse, they share common features in their interactions with the host that enable a protracted period of colonization. This article will compare the persistence strategies of two chronic pathogens from the Proteobacteria, Brucella abortus and Salmonella enterica serovar Typhi, to consider how these two pathogens, which are very different at the genomic level, can utilize common strategies to evade immune clearance to cause chronic intracellular infections of the mononuclear phagocyte system.
authors.affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Sacramento, CA 95817.
authors.forename: Mariana X
authors.initials: MX
authors.lastname: Byndloss
authors.affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Sacramento, CA 95817.
authors.forename: Renee M
authors.initials: RM
authors.lastname: Tsolis
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001419:Bacteria / Q000276:immunology / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000276:immunology / Q000382:microbiology*; D002908:Chronic Disease; D016207:Cytokines / Q000276:immunology; D006790:Host-Parasite Interactions; D006801:Humans; D057131:Immune Evasion; D007107:Immune System; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D016207:Cytokines