title: A Promoter Polymorphism in the CD46 Complement Regulatory Protein Gene Is Associated With Acute Renal Allograft Rejection.
abstract: OBJECTIVE
  CD46 molecule (complement regulatory protein [CD46]), known as a human cell surface receptor, plays an important role in complement and T-cell regulation for organ transplantation. This study was performed to evaluate the association of promoter polymorphism (rs2796267, -496 A/G) of the CD46 gene with acute renal allograft rejection (AR), late acute rejection (LAR), and graft loss (GL) in Korean patients.
  
  
  METHODS
  A total of 334 patients with kidney transplants were recruited. Transplantation outcomes were determined in terms of AR, LAR, and GL criteria. The promoter single nucleotide polymorphism (SNP) of CD46 was genotyped by direct sequencing.
  
  
  RESULTS
  The rs2796267 SNP exhibited significant differences between the AR group and non-AR group (codominant1 model, P = .012; odds ratio [OR], 0.47 [95% confidence interval, 0.26-0.84]; dominant model, P = .012; OR, 0.50 [95% CI, 0.29-0.86]; and allele distribution, P = .034; OR, 0.64 [95% CI, 0.43-0.94]). In addition, the SNP also exhibited significant associations with LAR (codominant2 model, P = .041; OR, 0.12 [95% CI, 0.02-0.92]; recessive model, P = .005; OR, 0.13 [95% CI, 0.02-0.94]; and allele distribution, P = .038; OR, 0.58 [95% CI, 0.35-0.97]).
  
  
  CONCLUSIONS
  This study suggests that the promoter polymorphism (rs2796267, -496 A/G) CD46 gene may be related to susceptibility of AR in Korean kidney transplantation recipients.
authors.affiliation: Department of Surgery, School of Medicine, Kyung Hee University, Republic of Korea.
authors.forename: M S
authors.initials: MS
authors.lastname: Park
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Republic of Korea.
authors.forename: S K
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Department of Nephrology, School of Medicine, Kyung Hee University, Republic of Korea.
authors.forename: T W
authors.initials: TW
authors.lastname: Lee
authors.affiliation: Department of Nephrology, School of Medicine, Kyung Hee University, Republic of Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Nephrology, School of Medicine, Kyung Hee University, Republic of Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Moon
authors.affiliation: Department of Nephrology, School of Medicine, Kyung Hee University, Republic of Korea.
authors.forename: C G
authors.initials: CG
authors.lastname: Ihm
authors.affiliation: Department of Nephrology, Inje University, Busan, Republic of Korea.
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Nephrology, Inje University, Busan, Republic of Korea.
authors.forename: S W
authors.initials: SW
authors.lastname: Kang
authors.affiliation: Department of Nephrology, School of Medicine, Kyung Hee University, Republic of Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Jeong
authors.affiliation: Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Republic of Korea. Electronic address: flyexcel@hanmail.net.
authors.forename: J-H
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000328:Adult; D000483:Alleles; D064591:Allografts; D044466:Asian People; D005260:Female; D005838:Genotype; D006084:Graft Rejection / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D051916:Membrane Cofactor Protein / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D056910:Republic of Korea
chemical_list: C497857:CD46 protein, human; D051916:Membrane Cofactor Protein