title: Genetics of systemic lupus erythematosus and Sjögren's syndrome: an update.
abstract: To describe the recent studies on the genetics of systemic lupus erythematosus (SLE) and Sjögren's syndrome.
  
  
  
  We overview the most recent findings on the genetic susceptibility of the diseases and provide information on their genetic similarities and differences.
  
  
  
  SLE and Sjögren's syndrome are two closely related systemic autoimmune diseases that share multiple clinical and molecular aspects, including a significant number of susceptibility genes. Several genome-wide association studies were recently published in different populations that provide a better picture of their molecular mechanisms. It is becoming clear that their genetic architecture is quite well established, but more information is required on expression quantitative trait loci, epigenetic genome-wide analyses, gene × gene interactions and the role of rare variants.
authors.affiliation: aGENYO, Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government, Parque Tecnológico de la Salud, Granada, Spain bUnit of Chronic Inflammatory Diseases, Institute for Environmental Medicine IMM, Karolinska Institutet, Solna, Sweden.
authors.forename: Maria
authors.initials: M
authors.lastname: Teruel
authors.forename: Marta E
authors.initials: ME
authors.lastname: Alarcón-Riquelme
mesh_terms: D039481:CD11b Antigen / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D059866:HLA-DQ beta-Chains / Q000235:genetics; D059811:HLA-DRB1 Chains / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D053278:OX40 Ligand / Q000235:genetics; D050797:STAT4 Transcription Factor / Q000235:genetics; D012859:Sjogren's Syndrome / Q000235:genetics* / Q000276:immunology; D028961:beta Karyopherins / Q000235:genetics
chemical_list: D039481:CD11b Antigen; D004268:DNA-Binding Proteins; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II; C431713:IRF5 protein, human; C509295:ITGAM protein, human; D050835:Interferon Regulatory Factors; D053278:OX40 Ligand; D050797:STAT4 Transcription Factor; C494090:STAT4 protein, human; C089251:TNFSF4 protein, human; C117046:TNIP1 protein, human; C546476:TNPO3 protein, human; D028961:beta Karyopherins