title: Interaction between renal function and percutaneous edge-to-edge mitral valve repair using MitraClip.
abstract: MitraClip (MC; Abbott Vascular, Menlo Park, CA, USA) is a treatment option for mitral regurgitation. Renal dysfunction is closely associated with cardiovascular disease. However, the influence of renal function in MC remains not fully understood. In this study, we aimed to clarify the association between renal function and MC.
  
  
  
  We examined 206 consecutive patients who underwent MC and divided patients into 3 groups according to estimated glomerular filtration rate (eGFR), normal eGFR (≥60mL/min/1.73m2) (n=70), mild chronic kidney disease (CKD) (30-59mL/min/1.73m2) (n=106), and severe CKD (<30mL/min/1.73m2) (n=30). N-terminal pro-B type natriuretic peptide (NT-pro BNP) levels increased with decreasing eGFR. Kaplan-Meier curves revealed that the long-term survival rate significantly decreased with eGFR. After adjustment with the covariates, severe CKD was still associated with mortality. Improved renal function was observed in 30% and associated with baseline lower NT-pro BNP levels. Patients with improved renal function had higher chronic phase survival rate.
  
  
  
  Renal dysfunction is common in MC patients and the survival rate decreased with eGFR in association with increased NT-pro BNP levels. MC may improve renal function in approximately 30% of MC patients. Improved renal function is associated with lower NT-pro BNP levels and results in satisfactory prognosis. These results implies a close association between renal function and MC treatment.
authors.affiliation: Department of Cardiology, Heart Center Brandenburg, Ladeburger Straße 17, 16321 Bernau, Germany; Department of Cardiology, Medical School Brandenburg, Ladeburger Straße 17, 16321 Bernau, Germany.
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Kaneko
authors.affiliation: Department of Cardiology, Heart Center Brandenburg, Ladeburger Straße 17, 16321 Bernau, Germany; Department of Cardiology, Medical School Brandenburg, Ladeburger Straße 17, 16321 Bernau, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Neuss
authors.affiliation: Department of Cardiology, Heart Center Brandenburg, Ladeburger Straße 17, 16321 Bernau, Germany; Department of Cardiology, Medical School Brandenburg, Ladeburger Straße 17, 16321 Bernau, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Schau
authors.affiliation: Department of Cardiology, Heart Center Brandenburg, Ladeburger Straße 17, 16321 Bernau, Germany; Department of Cardiology, Medical School Brandenburg, Ladeburger Straße 17, 16321 Bernau, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Weissenborn
authors.affiliation: Department of Cardiology, Heart Center Brandenburg, Ladeburger Straße 17, 16321 Bernau, Germany; Department of Cardiology, Medical School Brandenburg, Ladeburger Straße 17, 16321 Bernau, Germany. Electronic address: c.butter@immanuel.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Butter
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000601:surgery; D008944:Mitral Valve Insufficiency / Q000401:mortality* / Q000601:surgery*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000401:mortality*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: MitraClip; N-terminal pro-B type natriuretic peptide; Percutaneous edge-to-edge mitral valve repair; Renal function