title: [Bone disease in the field of CKD-MBD].
abstract: The pathophysiology and treatment for renal bone disease have made remakable progress. Moreover, osteocyte reseach has made tremendous progress. In the clinical aspect, (1) hyperphosphatemia, (2) hyperparathyroid and hypoparathyroid bone disease in patients with chronic kidney disease, (3) increased serum level of fibroblast growth factor 23 (FGF-23) and(4) reduced level of Klotho should be taken into consideration when analyzing these conditions. On the other hand, hyperphosphatemia must be successfully treated. Hyperparathyroid bone disease has been successfully treated with vitamin D sterol, cinacalcet hydrochloride and parathyroidectomy, however, the treatment of hypoparathyroidism inpatient with diabetes or non-diabetes met with high hurdles. We must treat these patients in thinking about osteocytic perilacunar/canalicular system.
authors.affiliation: Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis /Department of Anatomy and Cell Biology, Indiana University, School of Medicine, USA./Department of Medicine, Kidney Center, Tokyo Women's Medical University, Japan.
authors.forename: Aiji
authors.initials: A
authors.lastname: Yajima
authors.affiliation: Department of Medicine, Kidney Center, Tokyo Women's Medical University, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Tsuchiya
authors.affiliation: Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis/Department of Anatomy and Cell Biology, Indiana University, School of Medicine, USA.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yokota
authors.forename: Kosaku
authors.initials: K
authors.lastname: Nitta
mesh_terms: D001706:Biopsy; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism*
chemical_list: C000717427:FGF23 protein, human; D000089703:Fibroblast Growth Factor-23; D002118:Calcium