title: Release properties of tannic acid from hydrogen bond driven antioxidative cellulose nanofibrous films.
abstract: Layer-by-layer (LBL) assembled films have been exploited for surface-mediated bioactive compound delivery. Here, an antioxidative hydrogen-bonded multilayer electrospun nanofibrous film was fabricated from tannic acid (TA), acting as a polyphenolic antioxidant, and poly(ethylene glycol) (PEG) via layer-by-layer assembly. It overcame the burst release behavior of nanofibrous carrier, due to the reversible/dynamic nature of hydrogen bond, which was responded to external stimuli. The PEG/TA nanofibrous films disassembled gradually and released TA to the media, when soaked in aqueous solutions. The release rate of TA increased with increasing bilayer number, pH and temperature, but decreased with enhancing ionic strength. The surface morphology of the nanofibrous mats was observed by scanning electron microscopy (SEM). The following antioxidant activity assay revealed that it could scavenge DPPH free radicals and ABTS(+) cation radicals, a major biological activity of polyphenols. This technology can be used to fabricate other phenolic-containing slowly releasing antioxidative nanofibrous films.
authors.affiliation: College of Food Science and Technology, Shanghai Ocean University, No. 999 Huchenghuan Road, LinGang New City, Shanghai, 201306, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.affiliation: College of Food Science and Technology, Shanghai Ocean University, No. 999 Huchenghuan Road, LinGang New City, Shanghai, 201306, China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Hu
authors.affiliation: Research and Development Center, Henan Hengrui Starch Technology Company Limited, Luohe, Henan, 462000, China.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Research and Development Center, Henan Hengrui Starch Technology Company Limited, Luohe, Henan, 462000, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: College of Food Science and Technology, Shanghai Ocean University, No. 999 Huchenghuan Road, LinGang New City, Shanghai, 201306, China.
authors.forename: Xichang
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Food Science and Technology, Shanghai Ocean University, No. 999 Huchenghuan Road, LinGang New City, Shanghai, 201306, China. Electronic address: mfwang@shou.edu.cn.
authors.forename: Mingfu
authors.initials: M
authors.lastname: Wang
mesh_terms: D052160:Benzothiazoles / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D006860:Hydrogen Bonding; D057139:Nanofibers / Q000737:chemistry*; D036103:Nanotechnology; D010851:Picrates / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry; D013634:Tannins / Q000737:chemistry*; D013696:Temperature
chemical_list: D052160:Benzothiazoles; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D013451:Sulfonic Acids; D013634:Tannins; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; D011092:Polyethylene Glycols; D002482:Cellulose; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Antioxidant acitivity; Electrospun nanofibers; Hydrogen bonds; Layer-by-layer assembly; Polyphenolic drug