title: 4E-BP2 hardwires lymphocytes for rapamycin sensitivity.
abstract: The mTORC1 [mammalian (or mechanistic) target of rapamycin complex 1] inhibitor rapamycin is a potent inhibitor of T and B lymphocyte growth and proliferation. In this issue of Science Signaling, So et al found that the isoform of 4E-BP (4E-BP2) in lymphocytes that regulates messenger RNA translation is more sensitive to the effects of rapamycin than is the 4E-BP isoform found in nonlymphoid cells. Furthermore, inhibition of 4E-BP2 blocks both the growth and proliferation of lymphocytes.
authors.affiliation: Oncology-Rinat Research and Development Group, Pfizer Worldwide Research and Development, 10646 Science Center Drive/CB4, San Diego, CA 92121, USA. robert.abraham@pfizer.com.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Abraham
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D039561:Eukaryotic Initiation Factor-4E; D008214:Lymphocytes; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes; D020123:Sirolimus; D058570:TOR Serine-Threonine Kinases
chemical_list: D039561:Eukaryotic Initiation Factor-4E; D046912:Multiprotein Complexes; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus