title: Biochemical and biomechanical drivers of cancer cell metastasis, drug response and nanomedicine.
abstract: Metastasis, drug resistance and recurrence in cancer are regulated by the tumor microenvironment. This review describes recent advances in understanding how cancer cells respond to extracellular environmental cues via integrins, how to build engineered microenvironments to study these interactions in vitro and how nanomaterials can be used to detect and target tumor microenvironments.
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Yoshii
authors.affiliation: Molecular and Cellular Biology Program, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Geng
authors.affiliation: Department of Chemical Engineering, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA. Electronic address: speyton@ecs.umass.edu.
authors.forename: Shelly
authors.initials: S
authors.lastname: Peyton
authors.affiliation: Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: Arthur.Mercurio@umassmed.edu.
authors.forename: Arthur M
authors.initials: AM
authors.lastname: Mercurio
authors.affiliation: Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA; Molecular and Cellular Biology Program, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA. Electronic address: rotello@chem.umass.edu.
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D001696:Biomechanical Phenomena; D006801:Humans; D016023:Integrins / Q000502:physiology; D050997:Nanomedicine; D049329:Nanostructures; D009369:Neoplasms / Q000473:pathology*; D059016:Tumor Microenvironment
chemical_list: D016023:Integrins