title: Investigation of optical attenuation imaging using optical coherence tomography for monitoring of scars undergoing fractional laser treatment.
abstract: We demonstrate the use of the near-infrared attenuation coefficient, measured using optical coherence tomography (OCT), in longitudinal assessment of hypertrophic burn scars undergoing fractional laser treatment. The measurement method incorporates blood vessel detection by speckle decorrelation and masking, and a robust regression estimator to produce 2D en face parametric images of the attenuation coefficient of the dermis. Through reliable co-location of the field of view across pre- and post-treatment imaging sessions, the study was able to quantify changes in the attenuation coefficient of the dermis over a period of ∼20 weeks in seven patients. Minimal variation was observed in the mean attenuation coefficient of normal skin and control (untreated) mature scars, as expected. However, a significant decrease (13 ± 5%, mean ± standard deviation) was observed in the treated mature scars, resulting in a greater distinction from normal skin in response to localized damage from the laser treatment. By contrast, we observed an increase in the mean attenuation coefficient of treated (31 ± 27%) and control (27 ± 20%) immature scars, with numerical values incrementally approaching normal skin as the healing progressed. This pilot study supports conducting a more extensive investigation of OCT attenuation imaging for quantitative longitudinal monitoring of scars. En face 2D OCT attenuation coefficient map of a treated immature scar derived from the pre-treatment (top) and the post-treatment (bottom) scans. (Vasculature (black) is masked out.) The scale bars are 0.5 mm.
authors.affiliation: Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic & Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia.
authors.forename: Shaghayegh
authors.initials: S
authors.lastname: Es'haghian
authors.affiliation: Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic & Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia.
authors.forename: Peijun
authors.initials: P
authors.lastname: Gong
authors.affiliation: Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic & Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia.|BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, 6 Verdun Street, Nedlands, WA 6009.
authors.forename: Lixin
authors.initials: L
authors.lastname: Chin
authors.affiliation: Burns Service of Western Australia, Royal Perth Hospital, Wellington Street, Perth, WA 6000, Australia.
authors.forename: Karl-Anton
authors.initials: KA
authors.lastname: Harms
authors.affiliation: Burns Service of Western Australia, Royal Perth Hospital, Wellington Street, Perth, WA 6000, Australia.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Murray
authors.affiliation: Burns Service of Western Australia, Royal Perth Hospital, Wellington Street, Perth, WA 6000, Australia.|Burn Injury Research Unit, School of Surgery, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Rea
authors.affiliation: Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic & Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia.|BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre, 6 Verdun Street, Nedlands, WA 6009.
authors.forename: Brendan F
authors.initials: BF
authors.lastname: Kennedy
authors.affiliation: Burns Service of Western Australia, Royal Perth Hospital, Wellington Street, Perth, WA 6000, Australia.|Burn Injury Research Unit, School of Surgery, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Wood
authors.affiliation: Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic & Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia.|Centre for Microscopy, Characterisation & Analysis, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia.
authors.forename: David D
authors.initials: DD
authors.lastname: Sampson
authors.affiliation: Optical + Biomedical Engineering Laboratory, School of Electrical, Electronic & Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth, WA 6009, Australia.|ARC Centre of Excellence for Nanoscale BioPhotonics, School of Medicine, The University of Adelaide, Adelaide, SA 5005, Australia.
authors.forename: Robert A
authors.initials: RA
authors.lastname: McLaughlin
mesh_terms: D000328:Adult; D002056:Burns / Q000150:complications* / Q000000981:diagnostic imaging; D002245:Carbon Dioxide; D017439:Cicatrix, Hypertrophic / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D053685:Laser Therapy; D007834:Lasers; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D013997:Time Factors; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002245:Carbon Dioxide
keywords: ablative fractional laser treatment; attenuation coefficient; hypertrophic burn scars; optical attenuation; optical coherence tomography; scar assessment; speckle decorrelation; vasculature