title: Sitting time, physical fitness impairments and metabolic abnormalities in people with bipolar disorder: An exploratory study.
abstract: A sedentary lifestyle is an independent risk factor for cardiovascular disease and mortality. Little is known however about sedentary behavior in people with bipolar disorder (BD). The primary aim of this study was to explore associations between sitting time (as a proxy for a sedentary lifestyle) and physical fitness and metabolic parameters in BD. A secondary aim was to investigate associations between psychiatric symptoms, psychotropic medication use and sitting time. Thirty-nine (21♀) participants (43.7±12.4 years) completed a full metabolic screening, the sitting time item of the International Physical Activity Questionnaire, the Quick Inventory of Depressive Symptomatology self-report and the Hypomania Checklist-32. Additionally participants performed the Eurofit-test battery and 6-min walk test. The mean time spent sitting per day for the entire sample was 7.0±3.0h. A higher body mass index, worse physical fitness and higher antipsychotic medication dose were identified as independent predictors of higher levels of sitting behavior. The model explained 76.5% of the variability in the sitting time. Given that a sedentary lifestyle is an independent predictor of cardiovascular disease, future interventions specifically targeting time spend sitting are warranted in BD, with a particular emphasis on those with high body mass index and low fitness levels.
authors.affiliation: KU Leuven - University of Leuven, Department of Rehabilitation Sciences, Leuven, Belgium; KU Leuven - University of Leuven, University Psychiatric Center KU Leuven, Kortenberg, Leuven, Belgium. Electronic address: Davy.Vancampfort@uc-kortenberg.be.
authors.forename: Davy
authors.initials: D
authors.lastname: Vancampfort
authors.affiliation: KU Leuven - University of Leuven, University Psychiatric Center KU Leuven, Kortenberg, Leuven, Belgium.
authors.forename: Pascal
authors.initials: P
authors.lastname: Sienaert
authors.affiliation: KU Leuven - University of Leuven, University Psychiatric Center KU Leuven, Kortenberg, Leuven, Belgium.
authors.forename: Sabine
authors.initials: S
authors.lastname: Wyckaert
authors.affiliation: KU Leuven - University of Leuven, University Psychiatric Center KU Leuven, Kortenberg, Leuven, Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: De Hert
authors.affiliation: Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London, UK; Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, UK.
authors.forename: Brendon
authors.initials: B
authors.lastname: Stubbs
authors.affiliation: KU Leuven - University of Leuven, Department of Rehabilitation Sciences, Leuven, Belgium.
authors.forename: Michel
authors.initials: M
authors.lastname: Probst
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D002318:Cardiovascular Diseases / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010809:Physical Fitness / Q000523:psychology*; D011187:Posture; D012307:Risk Factors; D057185:Sedentary Behavior; D057566:Self Report; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents
keywords: Bipolar disorder; Depression; Exercise; Metabolic syndrome; Physical fitness; Sitting