title: Effect of a Ferric Citrate Formulation, a Phosphate Binder, on Oxidative Stress in Chronic Kidney Diseases-Mineral and Bone Disorder Patients Receiving Hemodialysis: A Pilot Study.
abstract: A ferric citrate formulation for treating hyperphosphatemia is a new therapeutic that not only suppresses the accumulation of phosphorus in patients with chronic kidney disease-mineral bone disorders (CKD-MBD), but also ameliorates anemia caused by iron deficiency. In contrast, it has been demonstrated that intravenous iron injection markedly increases oxidative stress. This study was designed to investigate the effect of a ferric citrate formulation on oxidative stress in CKD-MBD patients receiving hemodialysis therapy. Fifteen CKD-MBD patients undergoing dialysis were enrolled in this study. The patients were orally administered a ferric citrate formulation for 6 months. Their plasma phosphorus concentrations remained unchanged with the switch from other phosphorus adsorbents to the ferric citrate formulation. In addition, the ferric citrate formulation generally allowed for dose reduction of an erythropoiesis stimulating agent with an increased hematopoietic effect. The average values of plasma ferritin level increased after the introduction of a ferric citrate formulation, but did not exceed 100 (ng/mL). Interestingly, oxidative stress markers did not increase significantly, and anti-oxidative capacity was not significantly decreased at 6 months after the drug administration. Similarly, no change was observed in any inflammation markers. The ferric citrate formulation induces negligible oxidative stress in CKD-MBD patients receiving dialysis under the present clinical condition.
authors.affiliation: Department of Nephrology, Akebono Clinic.
authors.forename: Motoko
authors.initials: M
authors.lastname: Tanaka
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Miyamura
authors.forename: Tadashi
authors.initials: T
authors.lastname: Imafuku
authors.forename: Yuna
authors.initials: Y
authors.lastname: Tominaga
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Maeda
authors.forename: Makoto
authors.initials: M
authors.lastname: Anraku
authors.forename: Keishi
authors.initials: K
authors.lastname: Yamasaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kadowaki
authors.forename: Yu
authors.initials: Y
authors.lastname: Ishima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Tomoko
authors.initials: T
authors.lastname: Okuda
authors.forename: Kazuko
authors.initials: K
authors.lastname: Itoh
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Matsushita
authors.forename: Masafumi
authors.initials: M
authors.lastname: Fukagawa
authors.forename: Masaki
authors.initials: M
authors.lastname: Otagiri
authors.forename: Toru
authors.initials: T
authors.lastname: Maruyama
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000097:blood* / Q000188:drug therapy; D005260:Female; D005290:Ferric Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D005293:Ferritins / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D010710:Phosphates / Q000097:blood; D010758:Phosphorus / Q000097:blood; D006435:Renal Dialysis
chemical_list: D005290:Ferric Compounds; D010710:Phosphates; D010758:Phosphorus; C025314:ferric citrate; D005293:Ferritins