title: Locomotor-Reducing Activity of Sesquiterpenes Related to Zingiber zerumbet Essential Oil and Hexahydrozerumbone Derivatives.
abstract: Zerumbone derivatives 1-4 are 11-membered cyclic compounds synthesised from a sesquiterpene zerumbone obtained from the rhizomes of Zingiber zerumbet SMITH (Zingiberaceae). In this study, we investigated the locomotor-reducing effects of hexahydrozerumbone derivatives 1-3 and zerumbol 4, and those of β-caryophyllene 5 and caryophyllene oxide 6, which are present in Z. zerumbet essential oil. The absence of the double bond at C6 weakened the locomotor-reducing effects. β-Caryophyllene 5 and caryophyllene oxide 6 showed locomotor-reducing effects in mice at 4.5×10(-3) mg/cage. Moreover, locomotor activity increased significantly at 0.45 mg/cage of caryophyllene oxide 6.
authors.affiliation: Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University.
authors.forename: Kakuyou
authors.initials: K
authors.lastname: Ogawa
authors.forename: Hironobu
authors.initials: H
authors.lastname: Yabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitayama
authors.forename: Michiho
authors.initials: M
authors.lastname: Ito
mesh_terms: D000818:Animals; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D051379:Mice; D009822:Oils, Volatile; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D030521:Zingiberaceae
chemical_list: D009822:Oils, Volatile; D012717:Sesquiterpenes