title: Chinese Herbs Interfering with Cancer Reprogramming Metabolism.
abstract: Emerging evidence promotes a reassessment of metabolic reprogramming regulation in cancer research. Although there exists a long history of Chinese herbs applied in cancer treatment, few reports have addressed the effects of Chinese herbal components on metabolic reprogramming, which is a central cancer hallmark involved in the slowing or prevention of chemoresistance in cancer cells. In this review, we have focused on four core elements altered by metabolic reprogramming in cancer cells. These include glucose transport, glycolysis, mitochondrial oxidative phosphorylation, and fatty acid synthesis. With this focus, we have summarized recent advances in metabolic reprogramming of cancer cells in response to specific Chinese herbal components. We propose that exploring Chinese herbal interference in cancer metabolic reprogramming might identify new therapeutic targets for cancer and more ways in which to approach metabolism-related diseases.
authors.affiliation: Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau.
authors.forename: Zhangfeng
authors.initials: Z
authors.lastname: Zhong
authors.affiliation: Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau; Yale University, New Haven, CT 06511, USA.
authors.forename: William W
authors.initials: WW
authors.lastname: Qiang
authors.affiliation: School of Pharmacy, Lanzhou University, Lanzhou, Gansu 730000, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.affiliation: Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau.
authors.forename: Haotian
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau.
authors.forename: Shengpeng
authors.initials: S
authors.lastname: Wang
authors.affiliation: Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau.
authors.forename: Chunming
authors.initials: C
authors.lastname: Wang
authors.affiliation: Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, IL 60611, USA.
authors.forename: Wenan
authors.initials: W
authors.lastname: Qiang
authors.affiliation: Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau.
authors.forename: Yitao
authors.initials: Y
authors.lastname: Wang