title: Suppositional area for the search of bacterial products for anticancer therapy.
abstract: It is well-known that bacteria can produce compounds which show anticancer effects. In present time, it is impossible to check all bacterial species on their possible production of anticancer compounds (AC) under different conditions. Thus, it is necessary to limit the area for search of bacterial products for the anticancer therapy. We propose that production of AC by bacteria is a part of microbial biological strategy under natural conditions. We propose that bacteria in soils, in water and on plants do not meet human tumors and their AC serve for the competition with eukaryotic organisms. Most probably, an epiphytic growth of bacilli is accompanied with production of compounds inhibiting eukaryotes. According to awaited profit for the AC-producing bacteria, the epiphytic groups of bacilli show inhibition of mycelial fungi which are a natural model of eukaryotic cells. An example of strain isolation and a primary test is presented.
authors.affiliation: Institute of Biochemistry and Physiology of Microorganisms, Russ. Ac. Sci., Prospekt Nauki 5, Pushchino, Moscow Region 142290, Russia. Electronic address: tanica@rambler.ru.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Abashina
authors.affiliation: Institute of Biochemistry and Physiology of Microorganisms, Russ. Ac. Sci., Prospekt Nauki 5, Pushchino, Moscow Region 142290, Russia. Electronic address: klaur0315@gmail.com.
authors.forename: Kestutis
authors.initials: K
authors.lastname: Laurinavichius
authors.affiliation: Institute of Biochemistry and Physiology of Microorganisms, Russ. Ac. Sci., Prospekt Nauki 5, Pushchino, Moscow Region 142290, Russia; Pushchino State Institute of Natural Sciences, Prospekt Nauki 5, Pushchino, Moscow Region 142290, Russia. Electronic address: vain@ibpm.pushchino.ru.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Vainshtein
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001407:Bacillus / Q000737:chemistry; D001419:Bacteria / Q000737:chemistry*; D001688:Biological Products / Q000627:therapeutic use; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008297:Male; D008954:Models, Biological; D009369:Neoplasms / Q000628:therapy*; D008517:Phytotherapy / Q000379:methods; D012867:Skin / Q000382:microbiology
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products