The Amazing World of Peptide Engineering: the Example of Antimicrobial Peptides from Frogs and Their Analogues.
This review discusses the importance and properties of antimicrobial peptides from frogs and their synthetic analogues as potential therapeutic alternatives in fighting not only bacterial infections, but also protozoans involved with the major neglected diseases, which afflict human populations (e.g., Chagas disease, African sleeping sickness, Leishmaniasis and malaria). Here, we emphasize their multifunctional properties such as promising broad-spectrum drugs that target protozoan parasites too.
Aline B
AB
Guimarães
Fabiano J Q
FJ
Costa
Osmindo R
OR
Pires
Wagner
W
Fontes
Laboratory of Toxinology, Department of Physiological Sciences, Institute of Biology, University of Brasilia, Brasilia/DF, Brazil. mscastro@unb.br.
Mariana S
MS
Castro
D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D001001:Anura / Q000378:metabolism*; D014355:Chagas Disease / Q000188:drug therapy; D006801:Humans; D007896:Leishmaniasis / Q000188:drug therapy; D008288:Malaria / Q000188:drug therapy; D010271:Parasites / Q000187:drug effects*; D010455:Peptides / Q000378:metabolism* / Q000494:pharmacology* / Q000627:therapeutic use; D014353:Trypanosomiasis, African / Q000188:drug therapy
D000890:Anti-Infective Agents; D010455:Peptides