Functionalized graphene nanocomposites for enhancing photothermal therapy in tumor treatment.
Graphene and its derivatives have unique physical and chemical properties that make them promising vehicles for photothermal therapy (PTT)-based cancer treatment. With intrinsic near-infrared (NIR) absorption properties, graphene-based nanomaterials can be used for PTT and other therapeutics, particularly in combination therapy, to provide successful thermal ablation of cancer cells. In the recent years, advances in graphene-based PTT have produced efficient and efficacious tumor inhibition via nanomaterial structural design and different functionalizations of graphene-derived nanocomposites. Graphene-based nanosystems exhibit multifunctional properties that are useful for PTT applications including enhancement of multimodalities, guided imaging, enhanced chemotherapy and low-power efficient PTT for optimum therapeutic efficiency. Therefore, in this review, we address critical issues and future aspects of PTT-based combination therapy.
Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, Taiwan.
Yu-Wei
YW
Chen
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan.
Yu-Lin
YL
Su
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan. Electronic address: shhu@mx.nthu.edu.tw.
Shang-Hsiu
SH
Hu
Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, Taiwan. Electronic address: sanyuanchen@mail.nctu.edu.tw.
San-Yuan
SY
Chen
D000818:Animals; D003131:Combined Modality Therapy; D006108:Graphite / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use*; D009369:Neoplasms / Q000628:therapy*; D010789:Phototherapy
D006108:Graphite
Composites; Drug delivery; Graphene; Photothermal therapy; Tumor therapy