Evaluation of Clinical Pharmacists' Interventions in the Czech Republic.
To determine the frequency of interventions, categorized by type of intervention and therapeutic class, made by a team of four clinical pharmacists over a 1-year period, and to assess the potential economic impact of these interventions.



Prospective analysis.



Large medical center in Prague, Czech Republic.



A total of 9153 adults who were admitted to the general surgery, infectious diseases, oncology, orthopedics, and thoracic surgery and respiratory medicine services between January 1, 2014, and December 31, 2014.



Four clinical pharmacists reviewed patients' medication profiles, participated in medical and surgical rounds, and made drug therapy-related recommendations to physicians.



Clinical pharmacists' interventions were categorized by therapeutic class and divided into eight types: introduction of a drug, discontinuation of a drug, dosage change, route of administration change, recommendation to continue therapy, recommendation to perform further evaluation (e.g., laboratory assessment), reintroduction of a missing medication, and therapeutic drug monitoring (request to measure a drug concentration and provide its interpretation). All interventions accepted by the attending physicians were recorded by using a software application. For the evaluation of the economic impact of the interventions, published statistical data were used from the Institute of Health Information and Statistics of the Czech Republic. During the 1-year period, the clinical pharmacists performed 1916 interventions. The most frequent intervention was drug discontinuation (27.9% of all interventions), and the drug category with the highest frequency of interventions was central nervous system drugs (25.1%). All interventions were accepted by the physicians. For the evaluation of potential economic impact, a select group of drugs was used, representing 14.4% of the interventions. The benefit:cost ratio was 3:1.



All interventions made by clinical pharmacists were accepted by the physicians. Drug discontinuation was the most frequent intervention. The analysis of potential economic savings showed the positive impact of these interventions, with a benefit:cost ratio of 3:1.
Department of Clinical Pharmacy, Hospital Na Bulovce, Prague, Czech Republic.|Department of Applied Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
Jitka
J
Rychlíčková
Department of Applied Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
Jan
J
Šaloun
Department of Clinical Pharmacy, Hospital Na Bulovce, Prague, Czech Republic.
Jana
J
Gregorová
D000328:Adult; D017046:Cost Savings; D018153:Czech Republic; D016903:Drug Monitoring; D006801:Humans; D008508:Medication Errors / Q000517:prevention & control; D010595:Pharmacists; D010607:Pharmacy Service, Hospital; D024382:Professional Role; D011446:Prospective Studies
clinical pharmacy; drug-related problem; pharmacoeconomics