Atrial fibrillation in inherited cardiac channelopathies: From mechanisms to management.
Atrial fibrillation (AF) is prevalent in cardiac channelopathies and may be the presenting feature in some patients. The pathogenesis is related to the primary ion channel dysfunction in atrial myocytes that affects atrial conduction or repolarization. The development of AF is associated with adverse outcomes, and its management is challenging in these patients. In this article we review the current information on the prevalence, risk factors, pathophysiology, and treatment of AF in specific cardiac channelopathies.
Section of Cardiac Electrophysiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: andresaep@gmail.com.
Andres
A
Enriquez
Cardiovascular Research Program, Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.
Charles
C
Antzelevitch
Division of Cardiology, Queen's University, Kingston, Ontario, Canada.
Verdah
V
Bismah
Division of Cardiology, Queen's University, Kingston, Ontario, Canada.
Adrian
A
Baranchuk
D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D001281:Atrial Fibrillation / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D053840:Brugada Syndrome / Q000503:physiopathology; D053447:Channelopathies / Q000150:complications / Q000503:physiopathology*; D006325:Heart Atria / Q000503:physiopathology*; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D008133:Long QT Syndrome / Q000503:physiopathology; D032383:Myocytes, Cardiac / Q000502:physiology; D015995:Prevalence; D012307:Risk Factors
D007473:Ion Channels
Atrial fibrillation; Brugada syndrome; Catecholaminergic polymorphic ventricular tachycardia; Channelopathy; Long QT syndrome; Short QT syndrome