Will stem cells bring hope to pathological skin scar treatment?
Pathological skin scars, such as keloids, aesthetically and psychosocially affect patients. The quest for scar reduction and the increasing recognition of patient satisfaction has led to the continued exploration of scar treatment. Stem cells are a promising source for tissue repair and regeneration. The multi-potency and secretory functions of these cells could offer possible treatments for pathological scars and have been examined in recent studies. Here, we analyze the factors that influence the formation of pathological skin scars, summarize recent research on pathological scar treatment with stem cells and elaborate on the possible mechanisms of this treatment. Additionally, other effects of stem cell treatments are also presented while evaluating potential side effects of stem cell-based pathological scar treatments. Thus, this review may provide meaningful guidance in the clinic for scar treatments with stem cells.
Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, Beijing, China.
Qiankun
Q
Li
Stem Cell and Tissue Regeneration Laboratory, The First Affiliated Hospital, General Hospital of PLA, Beijing, China. Electronic address: zcp666666@sohu.com.
Cuiping
C
Zhang
Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, Beijing, China; Stem Cell and Tissue Regeneration Laboratory, The First Affiliated Hospital, General Hospital of PLA, Beijing, China. Electronic address: fuxiaobing@vip.sina.com.
Xiaobing
X
Fu
D000818:Animals; D002921:Cicatrix / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007627:Keloid / Q000473:pathology / Q000628:therapy; D012038:Regeneration / Q000502:physiology; D012867:Skin / Q000473:pathology; D033581:Stem Cell Transplantation / Q000379:methods / Q000639:trends; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D014945:Wound Healing
paracrine signaling; pathological scar; stem cells