Effect of glyphosate on reproductive organs in male rat.
Glyphosate as an active ingredient of Roundup(®) which is thought to be one of the most popular herbicide was used worldwide. Many studies have focused on reproductive toxicity on glyphosate-based herbicide, but few evidence exists to imply the male reproductive toxicity of glyphosate alone in vivo. In this study SD rats were Lavaged with glyphosate at doses of 5, 50, 500mg/kg to detect the toxicity of glyphosate on rat testis. Glyphosate significantly decreased the average daily feed intake at dose of 50mg/kg, and the weight of seminal vesicle gland, coagulating gland as well as the total sperm count at dose of 500mg/kg. Immunohistochemistry of androgen receptor (AR) has no difference among all groups. As to testosterone, estradiol, progesterone and oxidative stress parameters, the level of them has no differences amidst all doses. Taken together, we conclude that glyphosate alone has low toxicity on male rats reproductive system.
College of Animal Science and Technology, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.
Pengyuan
P
Dai
College of Animal Science and Technology, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.
Ping
P
Hu
College of Animal Science and Technology, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.
Juan
J
Tang
College of Animal Science and Technology, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.
Yansen
Y
Li
College of Animal Science and Technology, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China. Electronic address: chunmeili@njau.edu.cn.
Chunmei
C
Li
D000818:Animals; D002374:Catalase / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D005998:Glycine / Q000031:analogs & derivatives* / Q000633:toxicity; D006540:Herbicides / Q000633:toxicity*; D006861:Hydrogen Peroxide / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D011374:Progesterone / Q000097:blood; D017207:Rats, Sprague-Dawley; D011944:Receptors, Androgen / Q000378:metabolism; D013091:Spermatogenesis / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism; D013737:Testis / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D013739:Testosterone / Q000097:blood; D000097797:Glyphosate
D002374:Catalase; D004958:Estradiol; D005998:Glycine; D006540:Herbicides; D006861:Hydrogen Peroxide; D008315:Malondialdehyde; D011374:Progesterone; D011944:Receptors, Androgen; D013482:Superoxide Dismutase; D013739:Testosterone; D000097797:Glyphosate
Glyphosate; Oxidative stress; Rat; Reproductive organs