In vitro uptake of recombinant factor VIIa by megakaryocytes with subsequent production of platelets containing functionally active drug.
Surgical Research Laboratory, Department of Surgery, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Anne Marieke
AM
Schut
Surgical Research Laboratory, Department of Surgery, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Marc
M
Kirschbaum
Surgical Research Laboratory, Department of Surgery, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Jelle
J
Adelmeijer
Department of Clinical Chemistry and Haematology, University of Utrecht, University Medical Centre Utrecht, Utrecht, The Netherlands.
Philip G
PG
de Groot
Surgical Research Laboratory, Department of Surgery, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Ton
T
Lisman
D002460:Cell Line; D000074283:Endothelial Protein C Receptor / Q000378:metabolism; D015942:Factor VIIa / Q000378:metabolism*; D006801:Humans; D008533:Megakaryocytes / Q000187:drug effects / Q000502:physiology*; D011994:Recombinant Proteins / Q000378:metabolism*; D034061:Thrombopoiesis / Q000187:drug effects*
D000074283:Endothelial Protein C Receptor; C478370:PROCR protein, human; D011994:Recombinant Proteins; D015942:Factor VIIa
blood platelets; haemophilia; megakaryocytes; prophylaxis; recombinant FVIIa