Analysis of the Relationship between Antioxidant Enzyme Gene Polymorphisms and Their Activity in Post-Traumatic Gonarthrosis.
Analysis of polymorphisms of genes encoding antioxidant enzymes SOD1 (G7958A), SOD2 (T58C), CAT (C-262T), and GSTP1 (Ile105Val) in 93 patients with post-traumatic gonarthrosis showed that GSTP1 Ile105Val polymorphism is often associated with heterozygous mutation in catalase gene CAT C-262T. In gonarthrosis, catalase activity in peripheral blood mononuclear cells in patients with CT genotype of the C-262T locus of CAT gene more than 2-fold surpassed that in CC genotype and more than 50% surpassed the normal. Changes in the balance of activity of antioxidant enzymes can affect viability of mononuclear cells.
Southern Federal University, Rostov-on-Don, Russia.
V V
VV
Vnukov
Southern Federal University, Rostov-on-Don, Russia. tailana703@gmail.com.
S B
SB
Panina
Southern Federal University, Rostov-on-Don, Russia.
N P
NP
Milyutina
Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
I V
IV
Krolevets
Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
M A
MA
Zabrodin
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi / Q000235:genetics; D006801:Humans; D007718:Knee Injuries / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D013482:Superoxide Dismutase / Q000235:genetics
D000975:Antioxidants; D002374:Catalase; D013482:Superoxide Dismutase; D051549:Glutathione S-Transferase pi
antioxidant enzymes; gene polymorphism; post-traumatic gonarthrosis