Smart Implants as a Novel Strategy to Regenerate Well-Founded Cartilage.
Here we explore a new generation of smart, living implants, combining not only active therapeutics but also stem cells, as a novel strategy to regenerate stabilised cartilage and avoid prostheses. This process can regenerate the subchondral bone foundation, which is currently difficult in the clinic.
INSERM (French National Institute of Health and Medical Research), Osteoarticular and Dental Regenerative Nanomedicine Laboratory, ARTiOS Nanomed, Faculté de Médecine, FMTS, F-67085 Strasbourg Cedex, France; Université de Strasbourg, Faculté de Chirurgie Dentaire, 1 place de l'Hôpital, F-67000 Strasbourg, France.
Laetitia
L
Keller
INSERM (French National Institute of Health and Medical Research), Osteoarticular and Dental Regenerative Nanomedicine Laboratory, ARTiOS Nanomed, Faculté de Médecine, FMTS, F-67085 Strasbourg Cedex, France; Université de Strasbourg, Faculté de Chirurgie Dentaire, 1 place de l'Hôpital, F-67000 Strasbourg, France. Electronic address: pschwinte@unistra.fr.
Pascale
P
Schwinté
Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario La Paz, IdiPAZ, Universidad Autónoma de Madrid, Paseo de la Castellana 261, Madrid 28046, Spain.
Enrique
E
Gomez-Barrena
Department of Chemical Engineering and Aragon Nanoscience Institute, University of Zaragoza, C/Mariano Esquillor s/n 50018, Zaragoza, Spain.
Manuel
M
Arruebo
INSERM (French National Institute of Health and Medical Research), Osteoarticular and Dental Regenerative Nanomedicine Laboratory, ARTiOS Nanomed, Faculté de Médecine, FMTS, F-67085 Strasbourg Cedex, France; Université de Strasbourg, Faculté de Chirurgie Dentaire, 1 place de l'Hôpital, F-67000 Strasbourg, France. Electronic address: nadia.jessel@inserm.fr.
Nadia
N
Benkirane-Jessel
D000818:Animals; D002356:Cartilage / Q000166:cytology* / Q000254:growth & development*; D019902:Chondrocytes / Q000166:cytology* / Q000637:transplantation*; D004867:Equipment Design; D048091:Guided Tissue Regeneration / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods; D054457:Tissue Scaffolds