Characterization of a novel MICA allele, MICA*012:05, by cloning and sequencing.
A new MICA allelic variant, MICA*012:05, has been identified in a Chinese Mongolian population. Following polymerase chain reaction-sequence-based typing (PCR-SBT), this new allele was further confirmed by cloning and sequencing. MICA*012:05 was linked to an HLA-A*24-C*01-B*55:02-DRB1*09 haplotype. MICA*012:05 differs from MICA*012:01 by a single synonymous C to T substitution at nucleotide position 269 in exon 3.
Immunogenetics Research Group, Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, China.
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WY
Wang
Immunogenetics Research Group, Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, China.
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Tian
Immunogenetics Research Group, Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, China.
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Wang
HLA typing laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.|Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, China.
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Zhu
Immunogenetics Research Group, Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, China.
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Li
D000483:Alleles; D044466:Asian People; D002681:China; D005091:Exons / Q000235:genetics; D006239:Haplotypes / Q000235:genetics / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A