The potential utilizations of hydrogen as a promising therapeutic strategy against ocular diseases.
Hydrogen, one of the most well-known natural molecules, has been used in numerous medical applications owing to its ability to selectively neutralize cytotoxic reactive oxygen species and ameliorate hazardous inflammations. Hydrogen can exert protective effects on various reactive oxygen species-related diseases, including the transplantation-induced intestinal graft injury, chronic inflammation, ischemia-reperfusion injuries, and so on. Especially in the eye, hydrogen has been used to counteract multiple ocular pathologies in the ophthalmological models. Herein, the ophthalmological utilizations of hydrogen are systematically reviewed and the underlying mechanisms of hydrogen-induced beneficial effects are discussed. It is our hope that the protective effects of hydrogen, as evidenced by these pioneering studies, would enrich our pharmacological knowledge about this natural element and cast light into the discovery of a novel therapeutic strategy against ocular diseases.
Department of Ophthalmology, Chinese People's Liberation Army General Hospital, Ophthalmology & Visual Science Key Lab of PLA, Beijing, People's Republic of China.
Ye
Y
Tao
Department of Orthopaedics, Chinese People's Liberation Army General Hospital, Ophthalmology & Visual Science Key Lab of PLA, Beijing, People's Republic of China.
Lei
L
Geng
Department of Ophthalmology, Chinese People's Liberation Army General Hospital, Ophthalmology & Visual Science Key Lab of PLA, Beijing, People's Republic of China.
Wei-Wei
WW
Xu
Department of Ophthalmology, Chinese People's Liberation Army General Hospital, Ophthalmology & Visual Science Key Lab of PLA, Beijing, People's Republic of China.
Li-Min
LM
Qin
Department of Ophthalmology, Chinese People's Liberation Army General Hospital, Ophthalmology & Visual Science Key Lab of PLA, Beijing, People's Republic of China.
Guang-Hua
GH
Peng
Department of Ophthalmology, Chinese People's Liberation Army General Hospital, Ophthalmology & Visual Science Key Lab of PLA, Beijing, People's Republic of China.
Yi-Fei
YF
Huang
hydrogen; ocular diseases; therapeutic strategy