Meta-analysis update of association between dopamine transporter SLC6A3 gene polymorphism and smoking cessation.
The SLC6A3 gene is involved in the dopamine pathway, which influences smoking behavior. This study was conducted to present updated results of a meta-analysis to evaluate the association between SLC6A3 polymorphism and smoking cessation. In total, eight studies were assessed, and 9-repeat alleles and no 9-repeat alleles were compared by smoking cessation outcomes. No significant association between SLC6A3 genotype and smoking cessation was observed for the main analysis (odds ratio = 1.128; 95% confidence interval = 0.981-1.298). In conclusion, the genetic variations in SLC6A3 are not associated with smoking cessation, which is not consistent with the results of the previous meta-analysis.
1 Yeungnam University, Republic of Korea.
Hye Duck
HD
Choi
2 Seoul National University, Republic of Korea.
Wan Gyoon
WG
Shin
D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D006801:Humans; D012907:Smoking / Q000235:genetics*; D016540:Smoking Cessation
D050483:Dopamine Plasma Membrane Transport Proteins; C493214:SLC6A3 protein, human
genetic testing; health psychology; nicotine dependence; smoker; smoking cessation