The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations.
The remarkable success of immune therapies emphasizes the need for immune-competent cancer models. Elegant genetically engineered mouse models of a variety of cancers have been established, but their effective use is limited by cost and difficulties in rapidly generating experimental data. Some mouse cancer cell lines are transplantable to immunocompetent host mice and have been utilized extensively to study cancer immunology. Here, we describe the Yale University Mouse Melanoma (YUMM) lines, a comprehensive system of mouse melanoma cell lines that are syngeneic to C57BL/6, have well-defined human-relevant driver mutations, and are genomically stable. This will be a useful tool for the study of tumor immunology and genotype-specific cancer biology.
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Katrina
K
Meeth
Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA.
Jake Xiao
JX
Wang
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Goran
G
Micevic
Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA.
William
W
Damsky
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. marcus.bosenberg@yale.edu.|Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA. marcus.bosenberg@yale.edu.
Marcus W
MW
Bosenberg
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D014408:Biomarkers, Tumor / Q000235:genetics*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics*; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D051379:Mice; D020297:Mice, Congenic; D008810:Mice, Inbred C57BL; D009154:Mutation
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor
YUMM; cancer immunology; cell lines; melanoma; mouse models