Role of Brain NUCB2/nesfatin-1 in the Stress-induced Modulation of Gastrointestinal Functions.
BACKGROUND
Nucleobindin2 (NUCB2)/nesfatin-1 plays a well-established role in homeostatic functions associated with food intake and stress integration.


OBJECTIVE
This review focusses on NUCB2/nesfatin-1's central effects on gastrointestinal functions and will summarize the effects on food intake, motility and secretion with focus on the upper gastrointestinal tract.


RESULTS
We will highlight the stressors that influence brain NUCB2/nesfatin-1 expression and discuss functional implications. In addition to traditional acute psychological and physical stressors such as restraint stress and abdominal surgery we will look at immunological, visceral and metabolic stressors as well as a chronic combination stress model that have been shown to affect NUCB2/nesfatin-1 signaling and describe associated functional consequences.
Miriam
M
Goebel-Stengel
First Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Hindenburgdamm 30, 12200 Berlin, Germany.
Andreas
A
Stengel
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004435:Eating / Q000502:physiology / Q000523:psychology; D041981:Gastrointestinal Tract / Q000503:physiopathology*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D000080866:Nucleobindins; D013312:Stress, Physiological / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*
D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins