Physiological, pathological, and engineered cell identity reprogramming in the central nervous system.
Multipotent neural stem cells persist in restricted regions of the adult mammalian central nervous system. These proliferative cells differentiate into diverse neuron subtypes to maintain neural homeostasis. This endogenous process can be reprogrammed as a compensatory response to physiological cues, traumatic injury, and neurodegeneration. In addition to innate neurogenesis, recent research has demonstrated that new neurons can be engineered via cell identity reprogramming in non-neurogenic regions of the adult central nervous system. A comprehensive understanding of these reprogramming mechanisms will be essential to the development of therapeutic neural regeneration strategies that aim to improve functional recovery after injury and neurodegeneration. WIREs Dev Biol 2016, 5:499-517. doi: 10.1002/wdev.234 For further resources related to this article, please visit the WIREs website.
Department of Molecular Biology, The University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390, U.S.A.,.|Hamon Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390, U.S.A.,.
Derek K
DK
Smith
Department of Molecular Biology, The University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390, U.S.A.,.|Hamon Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390, U.S.A.,.
Leilei
L
Wang
Department of Molecular Biology, The University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390, U.S.A.,.|Hamon Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390, U.S.A.,.
Chun-Li
CL
Zhang
D000818:Animals; D002454:Cell Differentiation; D065150:Cellular Reprogramming / Q000502:physiology*; D002490:Central Nervous System / Q000503:physiopathology*; D006706:Homeostasis; D006801:Humans; D055495:Neurogenesis / Q000502:physiology*