Association between CYP2E1 polymorphisms and risk of gastric cancer: An updated meta-analysis of 32 case-control studies.
Previous studies suggested thatRsaI/PstI andDraI polymorphisms on cytochrome P450 2E1 (CYP2E1) may be associated with susceptibility to gastric cancer (GC). However, this association remains ambiguous. A meta-analysis of previously published studies was performed in an attempt to elucidate this association. The odds ratio and 95% confidence interval were used to assess the strength of the association. In the overall analyses ofRsaI/PstI andDraI, no association was identified. In the subgroup analyses,RsaI/PstI was identified to increase the risk of GC in the smoking population. In addition, in the previous studies of interactions with other genes,RsaI/PstI was revealed to be associated with increased GC risks when glutathione S-transferase-µ-1 or glutathione S-transferase θ-1 was null orDraI was homozygous wild-type. However, these stratified analyses were lacking credibility due to the limitation of correlational study numbers. In conclusion, CYP2E1 polymorphisms revealed no association with the risk of GC.
Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, P.R. China; Department of Gastrointestinal Surgery, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.
Ming-Xing
MX
Zhang
Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, P.R. China.
Kai
K
Liu
Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, P.R. China.
Fu-Gang
FG
Wang
Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, P.R. China.
Xiao-Wen
XW
Wen
Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, P.R. China.
Xi-Lin
XL
Song
DraI; RsaI/PstI; cytochrome P450 2E1; gastric cancer; meta-analysis; polymorphism