Delivery strategies and potential targets for siRNA in major cancer types.
Small interfering RNA (siRNA) has gained attention as a potential therapeutic reagent due to its ability to inhibit specific genes in many genetic diseases. For many years, studies of siRNA have progressively advanced toward novel treatment strategies against cancer. Cancer is caused by various mutations in hundreds of genes including both proto-oncogenes and tumor suppressor genes. In order to develop siRNAs as therapeutic agents for cancer treatment, delivery strategies for siRNA must be carefully designed and potential gene targets carefully selected for optimal anti-cancer effects. In this review, various modifications and delivery strategies for siRNA delivery are discussed. In addition, we present current thinking on target gene selection in major tumor types.
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115.|Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 6, Seongbuk-gu, Seoul 136-791, South Korea.
So Jin
SJ
Lee
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115.|Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 6, Seongbuk-gu, Seoul 136-791, South Korea.|KU-KIST School, Korea University, 1 Anam-dong, Seongbuk-gu, Seoul 136-701, Republic of Korea.
Min Ju
MJ
Kim
Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 6, Seongbuk-gu, Seoul 136-791, South Korea.|KU-KIST School, Korea University, 1 Anam-dong, Seongbuk-gu, Seoul 136-701, Republic of Korea.
Ick Chan
IC
Kwon
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115.
Thomas M
TM
Roberts
D016503:Drug Delivery Systems; D018390:Gene Targeting; D015316:Genetic Therapy; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage
D034741:RNA, Small Interfering
Cancer; Delivery strategy of siRNAs; Gene target; Small interfering RNA (siRNA); siRNA therapeutics