Dendrimer Prodrugs.
The main objective of this review is to describe the importance of dendrimer prodrugs in the design of new drugs, presenting numerous applications of these nanocomposites in the pharmaceutical field. Therefore, the use of dendrimer prodrugs as carrier for drug delivery, to improve pharmacokinetic properties of prototype, to promote drug sustained-release, to increase selectivity and, consequently, to decrease toxicity, are just some examples of topics that have been extensively reported in the literature, especially in the last decade. The examples discussed here give a panel of the growing interest dendrimer prodrugs have been evoking in the scientific community.
Laboratory of Design and Synthesis of Chemotherapeutics Potentially Active in Neglected Diseases (LAPEN), Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S&#227;o Paulo-USP, Avenue Professor Lineu Prestes, 580-Building 13, S&#227;o Paulo SP, 05508-900, Brazil. soraya.ssantos@yahoo.com.br.
Soraya
S
da Silva Santos
Laboratory of Design and Synthesis of Chemotherapeutics Potentially Active in Neglected Diseases (LAPEN), Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S&#227;o Paulo-USP, Avenue Professor Lineu Prestes, 580-Building 13, S&#227;o Paulo SP, 05508-900, Brazil. elizabeth.igne@gmail.com.
Elizabeth
E
Igne Ferreira
Laboratory of Design and Synthesis of Chemotherapeutics Potentially Active in Neglected Diseases (LAPEN), Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of S&#227;o Paulo-USP, Avenue Professor Lineu Prestes, 580-Building 13, S&#227;o Paulo SP, 05508-900, Brazil. jeanineg@usp.br.
Jeanine
J
Giarolla
D050091:Dendrimers / Q000737:chemistry* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D011355:Prodrugs / Q000737:chemistry* / Q000627:therapeutic use
D050091:Dendrimers; D011355:Prodrugs
dendrimer; molecular modifications; pharmaceutical applications; prodrugs; targeted dendrimer