Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum.
Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 8-24 μM.
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. miniezhao09@163.com.
Min
M
Zhao
The Fifth Affiliated Hospital, Wenzhou Medical University, Lishui 323000, China. lschengshimiao@163.com.
Shimiao
S
Cheng
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. yuan0525@126.com.
Weiping
W
Yuan
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. xiyiyuan2@163.com.
Yiyuan
Y
Xi
Key Laboratory of Marine Bio-Resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. lixiubao@scsio.ac.cn.
Xiubao
X
Li
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. jianyd@wzmc.edu.cn.
Jianyong
J
Dong
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. hkx@wzmc.edu.cn.
Kexin
K
Huang
Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA. gustafki@mail.nih.gov.
Kirk R
KR
Gustafson
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. yanpc@wzmc.edu.cn.|Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA. yanpc@wzmc.edu.cn.
Pengcheng
P
Yan
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D002681:China; D004224:Diterpenes / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000737:chemistry; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry
D004224:Diterpenes; D008070:Lipopolysaccharides; D009569:Nitric Oxide
Lobophytum crassum; NO inhibition; cembrane-based diterpenes; soft coral