Effect of PFOS on glucocorticoid-induced changes in human decidual stromal cells in the first trimester of pregnancy.
Perfluorooctane sulfonate (PFOS) is a surfactant and used in treating products for waterproofing and non-stick applications. PFOS has potential influence on reproductive function but the effect of PFOS exposure on the decidual functions remains unknown. By using primary human decidual stromal cells of early pregnancy we demonstrated that PFOS inhibited decidualization of the stromal cells as well as decidualization-induced upregulation of 11β-HSD1, an enzyme that regenerates biologically active cortisol from its inactive counterpart cortisone. Moreover, PFOS attenuated cortisol-induced decidualization and upregulation of 11β-HSD1 in the stromal cells. Furthermore, PFOS inhibited the reduction of IL-6 and IL-1β, the key proinflammatory cytokines in maternal-fetal immune intolerance, by cortisone in the decidual stromal cells indicating attenuated conversion of cortisone to cortisol. In conclusion, exposure to PFOS may disrupt the regeneration of cortisol in the decidual tissue thereby impairing the decidualization and immune-tolerance environment of early pregnancy.
Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, PR China; Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, PR China.
Qianlan
Q
Yang
Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, PR China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, PR China.
Wangsheng
W
Wang
Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, PR China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, PR China.
Chao
C
Liu
Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, PR China. Electronic address: renjiwangyu@gmail.com.
Yu
Y
Wang
Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, PR China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, PR China. Electronic address: sungangrenji@hotmail.com.
Kang
K
Sun
D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000235:genetics / Q000378:metabolism; D000328:Adult; D017738:Alkanesulfonic Acids / Q000633:toxicity*; D002478:Cells, Cultured; D003656:Decidua / Q000166:cytology*; D005260:Female; D005466:Fluorocarbons / Q000633:toxicity*; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000235:genetics / Q000378:metabolism; D011388:Prolactin / Q000235:genetics; D017154:Stromal Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D013501:Surface-Active Agents / Q000633:toxicity*; D055815:Young Adult
D017738:Alkanesulfonic Acids; D005466:Fluorocarbons; D005938:Glucocorticoids; C032231:IGFBP1 protein, human; C508600:IL6 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D053583:Interleukin-1beta; D015850:Interleukin-6; D013501:Surface-Active Agents; D011388:Prolactin; C076994:perfluorooctane sulfonic acid; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1; D006854:Hydrocortisone
11β-HSD1; Cortisol; Decidualization; PFOS; Proinflammatory cytokines