Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet press.
BACKGROUND
The negative impact of magnesium stearate (MgSt) on the hardness of tablets is a well-known phenomenon, but the influence of paddle movement in the forced feeder on the lubricant effect during tablet compression is often neglected.


OBJECTIVE
The purpose of this research was to investigate the influence of paddle speed in the forced feeder on tablet tensile strength (TS).


METHODS
Mixtures of microcrystalline cellulose (MCC) and MgSt (0.5%) were blended using different methods (low & high shear). After blending, the formulations were compressed into tablets. All parameters of the tableting cycle were kept constant except the speed of the paddles in the forced feeder.


CONCLUSIONS
The blending technique affected the sensitivity of the formulation to the paddle speed. The TS of pure MCC tablets did not change in function of paddle speed, while tablets prepared by low shear mixing became softer at higher paddle speed. The TS of tablets manufactured using the high-shear mixed blend was low and did not vary in function of paddle speed, suggesting that overlubrication already occurred during the initial blending step. Furthermore, analysis of the machine parameters allowed evaluation of the influence of the paddles on the flowability, initial packing, and compactability of the powder mixtures.


CONCLUSIONS
The results elucidated that during manufacturing of tablets using MgSt-containing blends care should not only be taken during the blending step prior to tableting, but also during the tableting process itself, as paddle speed can affect tablet TS, a critical quality attribute.
a Laboratory of Pharmaceutical Technology , Ghent University , Ghent , Belgium.
Elisabeth
E
Peeters
a Laboratory of Pharmaceutical Technology , Ghent University , Ghent , Belgium.
Valérie
V
Vanhoorne
a Laboratory of Pharmaceutical Technology , Ghent University , Ghent , Belgium.
Chris
C
Vervaet
a Laboratory of Pharmaceutical Technology , Ghent University , Ghent , Belgium.
Jean-Paul
JP
Remon
Blending; magnesium stearate; microcrystalline cellulose; shear; tableting; tensile strength