Pediatric Malignant Bone Tumors: A Review and Update on Current Challenges, and Emerging Drug Targets.
Osteosarcoma (OS) and the Ewing sarcoma family of tumors (ESFT) are the most common malignant bone tumors in children and adolescents. While significant improvements in survival have been seen in other pediatric malignancies the treatment and prognosis for pediatric bone tumors has remained unchanged for the past 3 decades. This review and update of pediatric malignant bone tumors will provide a general overview of osteosarcoma and the Ewing sarcoma family of tumors, discuss bone tumor genomics, current challenges, and emerging drug targets.
Division of Pediatric Hematology Oncology, NYU Langone Medical Center, New York, NY. Electronic address: Twana.Jackson@nyumc.org.
Twana M
TM
Jackson
Department of Radiology, NYU Langone Medical Center, New York, NY.
Mark
M
Bittman
Division of Pediatric Hematology Oncology, NYU Langone Medical Center, New York, NY.
Linda
L
Granowetter
D001706:Biopsy; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000209:etiology / Q000235:genetics / Q000628:therapy*; D001842:Bone and Bones / Q000473:pathology; D002648:Child; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D058990:Molecular Targeted Therapy / Q000379:methods; D012516:Osteosarcoma / Q000000981:diagnostic imaging* / Q000209:etiology / Q000235:genetics / Q000628:therapy*; D011379:Prognosis; D011859:Radiography; D012307:Risk Factors; D012512:Sarcoma, Ewing / Q000000981:diagnostic imaging / Q000209:etiology / Q000235:genetics / Q000628:therapy