Antimycotic Studies of Miconazole Nanovesicles Formulation vs Candida Strain.
OBJECTIVE
Present research work was aimed at formulation and evaluation of antifungal activity of miconazole nitrate (MN) vesicles vs C. albicans spp.<br />


METHODS
Miconazole loaded vesicles were prepared by coacervation phase separation technique using nonionic surfactants and stabilizers. The antimycological activity of vesicles was performed using agar disc diffusion technique.<br />


RESULTS
The miconazole nitrate lipid vesicles F5A and F5B showed maximum activity with higher zones of inhibition ie, 13.95+1.54 mm and 13.64+0.65 mm, respectively, after 3 days (For all comparisons, <em>P</em>&lt;.05 was considered significant).<br />


CONCLUSIONS
The findings of this study suggest antifungal potential of a novel preparation of miconazole nitrate vesicles vs Candida albicans in the treatment of mycoses in dermatological practice. <br /><br /> <em>J Drugs Dermatol. </em>2016;15(6):734-737.
Alka
A
Gupta
Hemanta Kumar
HK
Kar
D000935:Antifungal Agents / Q000008:administration & dosage* / Q000737:chemistry; D002176:Candida albicans / Q000187:drug effects* / Q000502:physiology; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D004339:Drug Compounding; D006801:Humans; D008825:Miconazole / Q000008:administration & dosage* / Q000737:chemistry; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry
D000935:Antifungal Agents; D004337:Drug Carriers; D008825:Miconazole