The rise of genomics.
A brief history of the development of genomics is provided. Complete sequencing of genomes of uni- and multicellular organisms is based on important progress in sequencing and bioinformatics. Evolution of these methods is ongoing and has triggered an explosion in data production and analysis. Initial analyses focused on the inventory of genes encoding proteins. Completeness and quality of gene prediction remains crucial. Genome analyses profoundly modified our views on evolution, biodiversity and contributed to the detection of new functions, yet to be fully elucidated, such as those fulfilled by non-coding RNAs. Genomics has become the basis for the study of biology and provides the molecular support for a bunch of large-scale studies, the omics.
Commissariat à l'énergie atomique et aux énergies alternatives, Institut de génomique, Genoscope, 2, rue Gaston-Crémieux, 91000 Évry, France; CNRS, Unité de génomique métabolique UMR8030, 2, rue Gaston-Crémieux, 91000 Évry, France; Université d'Évry, Unité de génomique métabolique UMR8030, 2, rue Gaston-Crémieux, 91000 Évry, France. Electronic address: jsbach@genoscope.cns.fr.
Jean
J
Weissenbach
D000818:Animals; D019295:Computational Biology; D004247:DNA / Q000235:genetics; D019143:Evolution, Molecular; D016678:Genome; D023281:Genomics / Q000266:history*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans
D004247:DNA
Bio-informatique; Bioinformatics; Evolution; Genomes; Génomes; Sequencing; Séquençage; Évolution