Effect of physical activity on IGF-1 and IGFBP levels in the context of civilization diseases prevention.
BACKGROUND
Insulin-like growth factor 1 (IGF-1) is known as somatomedin C. This polypeptide hormone is functionally and structurally similar to insulin. IGF-1 effects on tissue by the IGF-1R and the insulin-like growth factor-binding protein also known as IGFBP. Abnormal IGF-1 and IGFBP signaling are positively correlated with a high risk of selected civilization diseases development. Physical inactivity is a one of the main causes of majority of chronic diseases and it is associated with eg. IGF-1 and IGFBPs level.


OBJECTIVE
The aim of the study was to explanation the effect of physical activity on IGF-1 and its binding protein - IGFB- Ps concentration in the context of selected civilization diseases prevention. The review of clinical trial.


METHODS
The review of articles had published in databases: MEDLINE, EMBASE, Scopus and Web of Science until December 2015. The selected prospective studies about the effect of exercise on IGF-1 level and its binding protein IGFBP in the context of selected civilization diseases prevention were collected.


RESULTS
The majority of the included studies indicate that mechanical loading is a key mechanism linking IGF-1/IGFBPs con- centration and selected chronic diseases development. The duration and intensity of physical activity have a significant impact on IGF-1 and IGFBP serum. The highest concentration of IGF-1 in serum was after eccentric training. "Overtraining" increases unfavorable and unbound IGF-1 levels and contributes to the increased incidence of hormone-cancer and osteoarthritis.


CONCLUSIONS
Irregularity of the GH/IGF-1 axis may affect on the development of rheumatic diseases, cardiovascular dis- eases (regulate cardiac growth and metabolism) and metabolic syndrome.
Faculty of Health Sciences, Jagiellonian University Collegium Medicum, Cracow, Poland.
Marta
M
Majorczyk
Faculty of Medicine, Jagiellonian University Collegium Medicum, Cracow, Poland.
Danuta
D
Smoląg
D002318:Cardiovascular Diseases / Q000517:prevention & control; D002908:Chronic Disease / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control; D015444:Exercise / Q000502:physiology*; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D009043:Motor Activity; D009369:Neoplasms / Q000517:prevention & control
D018970:Insulin-Like Growth Factor Binding Protein 1; D007334:Insulin-Like Growth Factor I