Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents.
Nowadays, coffee beans are almost exclusively used for the preparation of the beverage. The sustainability of coffee production can be achieved introducing new applications for the valorization of coffee by-products. Coffee silverskin is the by-product generated during roasting, and because of its powerful antioxidant capacity, coffee silverskin aqueous extract (CSE) may be used for other applications, such as antiaging cosmetics and dermaceutics. This study aims to contribute to the coffee sector's sustainability through the application of CSE to preserve skin health. Preclinical data regarding the antiaging properties of CSE employing human keratinocytes and Caenorhabditis elegans are collected during the present study. Accelerated aging was induced by tert-butyl hydroperoxide (t-BOOH) in HaCaT cells and by ultraviolet radiation C (UVC) in C. elegans. Results suggest that the tested concentrations of coffee extracts were not cytotoxic, and CSE 1 mg/mL gave resistance to skin cells when oxidative damage was induced by t-BOOH. On the other hand, nematodes treated with CSE (1 mg/mL) showed a significant increased longevity compared to those cultured on a standard diet. In conclusion, our results support the antiaging properties of the CSE and its great potential for improving skin health due to its antioxidant character associated with phenols among other bioactive compounds present in the botanical material.
Institute of Food Science Research (CSIC-UAM), Nicol&#225;s Cabrera 9, 28049 Madrid, Spain. amaia.iriondo@csic.es.
Amaia
A
Iriondo-DeHond
Bi&#243;polis SL, Parc Cient&#237;fic Universitat de Valencia, Catedr&#225;tico Agust&#237;n Escardino 9, edificio 2, 46980 Valencia, Spain. patricia.martorell@biopolis.es.
Patricia
P
Martorell
Bi&#243;polis SL, Parc Cient&#237;fic Universitat de Valencia, Catedr&#225;tico Agust&#237;n Escardino 9, edificio 2, 46980 Valencia, Spain. salvador.genoves@biopolis.es.
Salvador
S
Genovés
Bi&#243;polis SL, Parc Cient&#237;fic Universitat de Valencia, Catedr&#225;tico Agust&#237;n Escardino 9, edificio 2, 46980 Valencia, Spain. daniel.ramon@biopolis.es.
Daniel
D
Ramón
Centro de Biolog&#237;a Molecular Severo Ochoa (CBM-SO) (CSIC-UAM), Nicol&#225;s Cabrera, 1, 28049 Madrid, Spain. kstamatakis@cbm.csic.es.
Konstantinos
K
Stamatakis
Centro de Biolog&#237;a Molecular Severo Ochoa (CBM-SO) (CSIC-UAM), Nicol&#225;s Cabrera, 1, 28049 Madrid, Spain. mfresno@cbm.csic.es.
Manuel
M
Fresno
Beacon Biomedicine, Parque Cient&#237;fico de Madrid, Santiago Grisolia 2, D130/L145, 28760 Madrid, Spain. amolina@advmedprojects.com.
Antonio
A
Molina
Institute of Food Science Research (CSIC-UAM), Nicol&#225;s Cabrera 9, 28049 Madrid, Spain. mdolores.delcastillo@csic.es.
Maria Dolores
MD
Del Castillo
D000375:Aging / Q000187:drug effects / Q000528:radiation effects; D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D015415:Biomarkers; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016922:Cellular Senescence / Q000187:drug effects; D040503:Coffea / Q000737:chemistry*; D006801:Humans; D016877:Oxidants / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D014466:Ultraviolet Rays
D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants; D010936:Plant Extracts; D017382:Reactive Oxygen Species
UVC radiation; accelerated aging; chlorogenic acid; coffee silverskin; dermaceutic; nutricosmetic; oxidative stress; skin health