The genetic burden of inflammatory bowel diseases: implications for the clinic?
Inflammatory bowel diseases (IBD), which include Crohn's disease (CD) and ulcerative colitis (UC), are characterized by chronic intestinal inflammation. Their etiology is multifactorial, with complex interactions between genetic and environmental factors, which are still largely unclear. Areas covered: The influence of genetics is clearly demonstrated by important epidemiological data, including familial aggregation and concordance in twins. In 2001, the first genetic susceptibility gene for IBD, the NOD2 gene, was identified. Currently, thanks to genetic wide association studies, over 200 susceptibility genetic markers are know. Expert commentary: However, clinically highly relevant gene associations are still very limited and the usefulness of these information in the current clinical strategies for treatment and surveillance of IBD is weak. Nevertheless, the recent identification of some genetic risk variants has clarified some newbiological pathways of these diseases thus paving the way for the discoveries in the near future of new targeted therapies.
a Division of Gastroenterology , AOU Careggi University Hospital , Florence , Italy.
Tommaso
T
Gabbani
a Division of Gastroenterology , AOU Careggi University Hospital , Florence , Italy.
Simona
S
Deiana
a Division of Gastroenterology , AOU Careggi University Hospital , Florence , Italy.
Antonio Luca
AL
Annese
b Division of Internal Medicine 4 , AOU Careggi University Hospital , Florence , Italy.
Sarah
S
Lunardi
a Division of Gastroenterology , AOU Careggi University Hospital , Florence , Italy.
Vito
V
Annese
Crohn’s disease; genetic risk factors; genetics; genotype/phenotype; inflammatory bowel disease; ulcerative colitis