Copper-Catalyzed Trifluoromethylation of Alkenes with Redox-Neutral Remote Amidation of Aldehydes.
A room-temperature and one-pot synthesis of ε-CF3-substituted amides via the copper-catalyzed trifluoromethylation of alkenes with redox-neutral remote amidation of aldehydes is described. This reaction is featured by an unprecedented 1,5-H atom abstraction from aldehydic C-H bonds by α-CF3-alkyl radicals resulting from the radical trifluoromethylation of alkenes, thus enabling a new possibility of the trifluoromethylation-initiated remote sp(2) C-H functionalization.
Department of Chemistry, Zhejiang Normal University , 688 Yingbin Road, Jinhua 321004, China.
Cungui
C
Cheng
Department of Chemistry, Zhejiang Normal University , 688 Yingbin Road, Jinhua 321004, China.
Shuiyou
S
Liu
Department of Chemistry, Zhejiang Normal University , 688 Yingbin Road, Jinhua 321004, China.
Danyang
D
Lu
Department of Chemistry, Zhejiang Normal University , 688 Yingbin Road, Jinhua 321004, China.
Gangguo
G
Zhu