The IFITMs Inhibit Zika Virus Replication.
Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad range of viruses, including the closely related flaviruses West Nile virus and dengue virus. Here, we show that IFITM1 and IFITM3 inhibit Zika virus infection early in the viral life cycle. Moreover, IFITM3 can prevent Zika-virus-induced cell death. These results suggest that strategies to boost the actions and/or levels of the IFITMs might be useful for inhibiting a broad range of emerging viruses.
Department of Microbiology and Physiological Systems (MaPS), University of Massachusetts Medical School, Worcester, MA 01655, USA.
George
G
Savidis
Department of Microbiology and Physiological Systems (MaPS), University of Massachusetts Medical School, Worcester, MA 01655, USA.
Jill M
JM
Perreira
Department of Microbiology and Physiological Systems (MaPS), University of Massachusetts Medical School, Worcester, MA 01655, USA.
Jocelyn M
JM
Portmann
Department of Microbiology and Physiological Systems (MaPS), University of Massachusetts Medical School, Worcester, MA 01655, USA.
Paul
P
Meraner
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Zhiru
Z
Guo
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Sharone
S
Green
Department of Microbiology and Physiological Systems (MaPS), University of Massachusetts Medical School, Worcester, MA 01655, USA; Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: abraham.brass@umassmed.edu.
Abraham L
AL
Brass
D000072283:A549 Cells; D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism*; D003588:Cytopathogenic Effect, Viral; D017353:Gene Deletion; D056426:Genetic Loci; D006367:HeLa Cells; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D021381:Protein Transport; D016601:RNA-Binding Proteins / Q000378:metabolism*; D014779:Virus Replication / Q000502:physiology*; D000071244:Zika Virus / Q000502:physiology*; D000071243:Zika Virus Infection
D000943:Antigens, Differentiation; C080082:IFITM3 protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins; C462181:fragilis protein, mouse; C062010:leu-13 antigen
IFITM; IFITM1; IFITM3; Zika virus; flavivirus; host factors; interferon; intrinsic immunity