Atopic dermatitis is not independently associated with nonfatal myocardial infarction or stroke among US women.
We aimed to determine the association between atopic dermatitis (AD) and cardiovascular events in the Nurses' Health Study 2, a cohort of US women. We used logistic regression models to calculate age- and multivariate-adjusted odds ratios (OR) and 95% confidence intervals (CI) for the associations between history of AD and nonfatal MI and nonfatal stroke. Of the 78 702 participants in our analysis, 7916 (10%) had a history of AD. There were 392 and 391 cases of nonfatal MI and stroke, respectively. AD was not associated with MI in age- or multivariate-adjusted analyses. AD was significantly associated with stroke in the age-adjusted analysis (OR 1.38, 95% CI 1.03-1.85). This was no longer significant in multivariate models that adjusted for hypertension, hypercholesterolemia and diabetes (OR 1.31, 95% CI 0.98-1.76) and atopic comorbidities (OR 1.17, 95% CI 0.86-1.58). AD was not independently associated with nonfatal MI or stroke in this study.
Department of Dermatology, Warren Alpert Medical School, Providence, RI, USA.|Department of Dermatology, Rhode Island Hospital, Providence, RI, USA.|School of Public Health, Brown University, Providence, RI, USA.
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Drucker
Department of Dermatology, Warren Alpert Medical School, Providence, RI, USA.|Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.
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Li
Department of Dermatology, Warren Alpert Medical School, Providence, RI, USA.|Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.|Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
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Cho
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
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Li
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.|Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
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Sun
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.|Department of Emergency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.|Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
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Camargo
Department of Dermatology, Warren Alpert Medical School, Providence, RI, USA. abrar_qureshi@brown.edu.|Department of Dermatology, Rhode Island Hospital, Providence, RI, USA. abrar_qureshi@brown.edu.|Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA. abrar_qureshi@brown.edu.|Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. abrar_qureshi@brown.edu.
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Qureshi
D015897:Comorbidity; D003876:Dermatitis, Atopic / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications* / Q000453:epidemiology*; D016017:Odds Ratio; D011159:Population Surveillance; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000150:complications* / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology
atopic dermatitis; cardiovascular disease; comorbidity; myocardial infarction; stroke