[Non-alcoholic fatty liver disease and hepatocellular carcinoma - 2016].
In the past decade non-alcoholic liver disease became the most frequently diagnosed liver disease in developed countries. At the same time, the dramatic rise in the incidence of hepatocellular carcinoma is attributed to this common metabolic disorder, and mainly to its severe form, non-alcoholic steatohepatitis. The risk factors of these associated diseases are genetic predisposition, obesity and diabetes as well as chronic low grade necro-infammation, which often leads to liver fibrosis. Free fatty acids, cytokines, lipotoxicity, insulin resistance, microRNS dysregulation and alteration in intestinal microbiota play a pivotal role in the pathogenesis. Treatment of non-alcoholic fatty liver disease - weight reduction and physical exercise in obesity, metformin in diabetes, statins in dyslipidemia and, as a new option, obeticholic acid - may diminish the risk of the hepatocellular carcinoma related to this metabolic disease.
Klinikai Központ, I. Belgyógyászati Klinika, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs, Ifjúság útja 13., 7624.
Alajos
A
Pár
Klinikai Központ, I. Belgyógyászati Klinika, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs, Ifjúság útja 13., 7624.
Gabriella
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Pár
D015992:Body Mass Index; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control*; D048909:Diabetes Complications / Q000453:epidemiology; D004032:Diet; D044127:Epigenesis, Genetic; D015444:Exercise; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control*; D008403:Mass Screening; D024821:Metabolic Syndrome / Q000150:complications; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D009765:Obesity / Q000150:complications*; D011159:Population Surveillance; D040242:Risk Reduction Behavior; D015431:Weight Loss
D005230:Fatty Acids, Nonesterified
bél-baktériumflóra; cancer prevention; citokinek; cytokines; daganatprevenció; diagnosis; diagnózis; genetics; genetika; hepatocellular carcinoma; hepatocellularis carcinoma; insulin resistance; intestinal microbiota; inzulinrezisztencia; microRNA; mikro-RNS; nem alkoholos steatohepatitis; nem alkoholos zsírmáj; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; obeticholic acid; obetikólsav; surveillance; szűrés; terápia; treatment