Iron Overload or Oxidative Stress? Insight into a Mechanism of Early Cardiac Manifestations of Asymptomatic Hereditary Hemochromatosis Subjects with C282Y Homozygosity.
Hereditary hemochromatosis (HH) is a genetic disorder which affects the heart due to systemic iron overload and concomitant elevated oxidative stress. Increasing numbers of patients are diagnosed at an asymptomatic stage due to genetic testing. Subclinical abnormal left ventricular diastolic function (LVDF) and increased arrhythmias are noted in this population; however, the mechanism leading to these observances has not been well understood. In this study, we assessed the relationship between arrhythmia activity and biomarkers of oxidative stress and iron overload in order to elucidate the role of oxidative stress in this population since we observed a significant association with LVDF previously. A significant correlation between plasma malondialdehyde, a biomarker of oxidative stress, and supraventricular arrhythmia activity without a significant association with iron overload was identified (n = 22). Our findings further highlight a possible role of oxidative stress in early cardiac manifestations of HH. Further investigation is warranted to assess this role.
Cardiopulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. shizukya@uc.edu.|Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA. shizukya@uc.edu.|Cincinnati VA Medical Center, Cincinnati, OH, USA. shizukya@uc.edu.
Yukitaka
Y
Shizukuda
Cardiopulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Dorothy J
DJ
Tripodi
Cardiopulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Douglas R
DR
Rosing
D001145:Arrhythmias, Cardiac / Q000097:blood / Q000235:genetics; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D009202:Cardiomyopathies / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006432:Hemochromatosis / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D000071020:Hemochromatosis Protein / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008315:Malondialdehyde / Q000097:blood; D009206:Myocardium / Q000378:metabolism*; D018384:Oxidative Stress; D010641:Phenotype; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000235:genetics
D015415:Biomarkers; C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D008315:Malondialdehyde; D007501:Iron
Arrhythmia; Biomarkers; Electrocardiogram; Hemochromatosis; Iron overload; Oxidative stress