Effect of GT-Peptide 10 and Triethyl Citrate on <em>P. acnes</em> Biofilm Formation, Viability, and Dispersion.
BACKGROUND
P. acnes biofilms are emerging topics in acne vulgaris pathogenesis and may be responsible for antibiotic tolerance.<br/>


OBJECTIVE
To investigate the efficacy of GT peptide 10 either alone or in combination with triethyl citrate (TEC) in in vitro model of P. acnes biofilm.<br/>


METHODS
Six-day-old P. acnes biofilms were treated with various concentrations of these substances and biofilm dispersion and cell viability were monitored.<br/>


RESULTS
A 24-hour exposure of preformed biofilms to a combination of GT peptide 10/TEC led to killing of up to 92% of bacterial cells inside the biofilm. Neither the single substance nor the combination of both substances affected the biofilm integrity or resulted in biofilm dispersal.<br/>


CONCLUSIONS
A combination of GT peptide 10/TEC shows antibacterial effects in in vitro model of P. acnes biofilm. <br /><br /> <em>J Drugs Dermatol. </em>2016;15(6):778-781.
Hinnerk
H
Eilers
Oleg A
OA
Alexeyev
D000152:Acne Vulgaris / Q000188:drug therapy; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002951:Citrates / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D010446:Peptide Fragments / Q000008:administration & dosage*; D011425:Propionibacterium acnes / Q000187:drug effects* / Q000502:physiology; D016896:Treatment Outcome
D002951:Citrates; D010446:Peptide Fragments; C023001:ethyl citrate