Recent advances in abuse-deterrent technologies for the delivery of opioids.
Over the past decade, the abuse of prescription opioid drugs has become a national health crisis in the United States. Pharmaceutical companies, the Food and Drug Administration, and other government agencies are confronting opioid abuse by developing and commercializing various abuse-deterrent drug delivery technologies. To deter opioid abuse, various strategies including physical barriers, chemical barriers, antagonists, aversive agents, and prodrugs have been investigated. A number of drug products with abuse-deterrent properties have been approved by the FDA over the last six years, while many products and technologies with progressively-improved abuse-deterrence properties are currently being evaluated. This article provides a comprehensive review of the material sciences principles that govern the formulation and processing of a wide range of abuse-deterrent products and technologies.
Department of Pharmaceutics, The University of Texas, Austin 2409 University Avenue, A1920, Austin, TX 78712, USA.
Julien
J
Maincent
Department of Pharmaceutics, The University of Texas, Austin 2409 University Avenue, A1920, Austin, TX 78712, USA. Electronic address: feng.zhang@austin.utexas.edu.
Feng
F
Zhang
D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000737:chemistry*; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods / Q000639:trends*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends*; D006801:Humans; D009293:Opioid-Related Disorders / Q000517:prevention & control*
D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations
Abuse deterrence; Opioid delivery; Sustained release; Tamper resistant