Towards Leanness by 'Feeding' a Novel Thermogenic Pathway?
Upon activation, brown and beige adipocytes help to fight excessive fat in rodents, and their oxidative properties can be induced by cooling, capsinoids, and fish oil. New research now suggests that synergistic anti-obesity effects can be achieved by combining such strategies, and that a novel pathway mediates part of the effect.
Obesity Research Section, Department of Nutrition, Exercise, and Sports, University of Copenhagen, 1958 Frederiksberg C, Denmark; Section for Metabolic Imaging and Liver Metabolism, the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: jlund@nexs.ku.dk.
Jens
J
Lund
Section for Metabolic Imaging and Liver Metabolism, the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 2200 Copenhagen N, Denmark; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
Matthew Paul
MP
Gillum
D000818:Animals; D005395:Fish Oils / Q000494:pharmacology; D006801:Humans; D018343:Receptors, Adrenergic, beta-2 / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D050916:TRPV Cation Channels / Q000378:metabolism; D022722:Thermogenesis / Q000187:drug effects / Q000235:genetics; D013851:Thinness / Q000209:etiology / Q000378:metabolism*
D005395:Fish Oils; D018343:Receptors, Adrenergic, beta-2; D050916:TRPV Cation Channels; C494484:TRPV1 receptor
TRPV1; beiging; beta2-adrenoceptors; capsinoids; fish oil