Kinetic Chemiluminescence as a Method for Oxidative Stress Evaluation in Examinations of Patients with Type 2 Diabetes Mellitus.
We propose a new approach to evaluation of oxidative stress based on kinetic chemiluminescence: measurement of antioxidant and pro-oxidant activities of the plasma. The study included 50 patients with type 2 diabetes mellitus receiving peroral hypoglycemic therapy. In addition to the above parameters, the levels of TBA-reactive products, inflammation markers, clotting parameters, and biochemical values were studied. The new method provides information on oxidative stress in patients with type 2 diabetes mellitus irrespective of the clinical and laboratory values. The use of this method in complex with the clinical, laboratory, and instrumental studies allows comprehensive evaluation of patient's status for the diagnosis and choice of therapy.
Faculty of Basic Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia. proskurnina@gmail.com.
E V
EV
Proskurnina
Faculty of Basic Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia.
A M
AM
Polimova
Faculty of Basic Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia.
M M
MM
Sozarukova
Russian Medical Academy of Postgraduate Education, Moscow, Russia.
M A
MA
Prudnikova
Russian Medical Academy of Postgraduate Education, Moscow, Russia.
A S
AS
Ametov
Faculty of Basic Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia.
Yu A
YA
Vladimirov
D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007700:Kinetics; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000975:Antioxidants; D015415:Biomarkers; D017392:Thiobarbituric Acid Reactive Substances
blood plasma; kinetic chemiluminescence; oxidative stress; type 2 diabetes mellitus