Increased serum concentrations of signal peptide-Cub-Egf domain-containing protein-1 in patients with aneurysmal subarachnoid hemorrhage.
BACKGROUND
Signal peptide-Cub-Epidermal growth factor domain-containing protein 1 (SCUBE1), a marker for coagulation, is correlated with prognosis of some critical illnesses. The current study was designed to investigate the potential prognostic value of serum SCUBE1 concentrations in patients with aneurysmal subarachnoid hemorrhage (aSAH).


METHODS
Serum SCUBE1 concentrations of 125 patients and 125 controls were determined. Multivariate analyses were performed to identify independent risk factors for 6-month mortality, overall survival and unfavorable outcome (Glasgow Outcome Scale score of 1-3).


RESULTS
Serum SCUBE1 concentrations were significantly higher in patients than in controls (17.7±7. vs. 1.2±0.4ng/ml, P<0.001) and were associated highly with World Federation of Neurological Surgeons (WFNS) scores (t=5.109, P<0.001) and modified Fisher scores (t=4.329, P<0.001). SCUBE1 emerged as an independent predictor for 6-month clinical outcomes. It had similar area under receiver operating characteristic curve (AUC) to WFNS scores and modified Fisher scores. Moreover, it could markedly improve the AUC of WFNS scores and modified Fisher scores to predict 6-month unfavorable outcome.


CONCLUSIONS
Enhanced SCUBE1 concentrations are correlated with increasing severity and poor outcomes of aSAH patients, indicating SCUBE1 might have the potential to identify aSAH patients at risk of poor prognosis.
Department of Neurosurgery, Taizhou People's Hospital, Nantong University, 210 Yingchun Road, Taizhou, Jiangsu Province 225300, China. Electronic address: zhongguoreng2015@163.com.
Ya-Suo
YS
Ding
Department of Neurosurgery, Taizhou People's Hospital, Nantong University, 210 Yingchun Road, Taizhou, Jiangsu Province 225300, China.
Bing
B
Sun
Department of Neurosurgery, Taizhou People's Hospital, Nantong University, 210 Yingchun Road, Taizhou, Jiangsu Province 225300, China.
Jian-Xin
JX
Jiang
Department of Neurosurgery, Taizhou People's Hospital, Nantong University, 210 Yingchun Road, Taizhou, Jiangsu Province 225300, China.
Qin
Q
Zhang
Department of Neurosurgery, Taizhou People's Hospital, Nantong University, 210 Yingchun Road, Taizhou, Jiangsu Province 225300, China.
Jun
J
Lu
Department of Neurosurgery, Taizhou People's Hospital, Nantong University, 210 Yingchun Road, Taizhou, Jiangsu Province 225300, China.
Guang-Zhong
GZ
Gao
D002135:Calcium-Binding Proteins; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D013345:Subarachnoid Hemorrhage / Q000097:blood*
D002135:Calcium-Binding Proteins; D008565:Membrane Proteins; C469998:SCUBE1 protein, human
Intracranial aneurysmal; Prognosis; Severity; Signal peptide-Cub-Epidermal growth factor domain-containing protein 1; Subarachnoid hemorrhage