Horizontal Ridge Augmentation using GBR with a Native Collagen Membrane and 1:1 Ratio of Particulated Xenograft and Autologous Bone: A 1-Year Prospective Clinical Study.
OBJECTIVE
To clinically and radiographically evaluate bone regeneration of severe horizontal bone defects.


METHODS
This study was designed as a single cohort, prospective clinical trial. Partially or fully edentulous patients, having less then 4 mm of residual horizontal bone width were selected and consecutively treated with resorbable collagen membranes and a 1:1 mixture of particulated anorganic bovine bone and autogenous bone, 7 months before implant placement. Tapered body implants were inserted and loaded 3 to 6 months later with a screw retained crown or bridge. Outcomes were: implant survival rate, any biological and prosthetic complications, horizontal alveolar bone dimensional changes measured on cone beam computed tomography (CBCT) taken at baseline and at implant insertion, peri-implant marginal bone level changes measured on periapical radiographs, plaque index (PI), and bleeding on probing index (BoP).


RESULTS
Eighteen consecutive patients (11 females, 7 males) with a mean age of 56.8 years (range 24-78) and 22 treated sites received 55 regular platform implants. No patient dropped-out and no implants failed during the entire follow-up, resulting in a cumulative implant survival rate of 100%. No prosthetic or biological complications were recorded. Supraimposition of pre- and 7-month post-operative CBCT scans revealed an average horizontal bone gain of 5.03 ± 2.15 mm (95% CI: 4.13-5.92 mm). One year after final prosthesis delivery, mean marginal bone loss was 1.03 ± 0.21 mm (95% CI 0.83-1.17 mm). PI was 11.1% and BoP was 5.6%.


CONCLUSIONS
Within the limitation of the present study, high implant survival rate and high average bone augmentation seem to validate the use of collagen resorbable membranes with a 1:1 mixture of particulated anorganic bovine bone and autogenous bone, for the reconstruction of severe horizontal ridge defects.
Assistant Professor, University of Sassari, Italy.
Silvio Mario
SM
Meloni
associated professor, Loma Linda University, CA, USA.
Sascha A
SA
Jovanovic
Assistant professor, Loma Linda University, CA, USA; Urban Regeneration Institute, Budapest, Hungary.
Istvan
I
Urban
Independent Researcher in Rome, Rome, Italy.
Luigi
L
Canullo
private practice in Sassari, Italy.
Milena
M
Pisano
Lecturer, University of Sassari, Italy.
Marco
M
Tallarico
D020341:Absorbable Implants; D000328:Adult; D000368:Aged; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D016025:Bone Transplantation / Q000379:methods*; D015331:Cohort Studies; D003094:Collagen; D054893:Cone-Beam Computed Tomography; D005260:Female; D005500:Follow-Up Studies; D064593:Heterografts; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D009066:Mouth, Edentulous / Q000000981:diagnostic imaging / Q000601:surgery*; D011183:Postoperative Complications / Q000000981:diagnostic imaging; D011446:Prospective Studies
D008567:Membranes, Artificial; D003094:Collagen
alveolar ridge reconstruction; atrophy; autologous bone; bone augmentation; bone defects; bone regeneration; bone substitutes; xenograft