[Goodpasture Syndrome: a Rare Cause of Acute Anuric Renal Failure].
We report a case of a 68 year old male who presented with an acute onset of anuric renal failure. Investigations revealed a histologically confirmed “double-positive” anti-GBM disease with initially undetectably high antibody values. An induction therapy with plasma exchange, cyclophosphamide and initially high dose steroids and further maintenance therapy for three months was initiated. The patient remained dialysis-dependent despite partial recovering of renal function. Without pulmonary involvement there were no clues for Goodpasture’s disease. Renal prognosis is unfavourable.
1 Klinik für Transplantationsimmunologie und Nephrologie, Universitätsspital Basel.
Dirk
D
Bareiss
2 Pathologisches Institut, Universitätsspital Basel.
Helmut
H
Hopfer
2 Pathologisches Institut, Universitätsspital Basel.
Thomas
T
Menter
1 Klinik für Transplantationsimmunologie und Nephrologie, Universitätsspital Basel.
Andreas
A
Jehle
1 Klinik für Transplantationsimmunologie und Nephrologie, Universitätsspital Basel.
Felix
F
Burkhalter
D058186:Acute Kidney Injury / Q000175:diagnosis*; D000368:Aged; D000465:Algorithms; D019867:Anti-Glomerular Basement Membrane Disease / Q000175:diagnosis*; D001002:Anuria / Q000209:etiology*; D001323:Autoantibodies / Q000097:blood; D003371:Cough / Q000209:etiology; D003937:Diagnosis, Differential; D050533:Glomerular Basement Membrane / Q000276:immunology; D006801:Humans; D008297:Male; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000175:diagnosis
D001323:Autoantibodies
Goodpasture-Syndrom; Gooodpasture Syndrome; Plasmapherese; acute renal failure; akutes Nierenversagen; plasmaexchange; rapid-progressive Glomerulonephritis; rapidly progressive glomerulonephritis; «doppelt positive» Anti-GBM- Erkrankung; “double positive” anti GBM disease