P300 amplitude alterations during inhibitory control in persons with Mild Cognitive Impairment.
Deficits in executive function are highly noticeable in Alzheimer's disease, and recent behavioral studies have shown that such deficits - particularly during inhibitory control - can also be found in persons with Mild Cognitive Impairment (MCI). Thus, the objective of this study was to investigate behavioral and electrophysiological correlates of inhibitory control in persons with MCI. A group of persons with MCI and a group healthy older adults performed a Go/NoGo task while electroencephalogram was recorded. Our results revealed that persons with MCI performed less accurately than healthy controls during the Go and NoGo conditions. In addition, we found reduced P300 amplitudes during Go and NoGo conditions relative to healthy older adults. Our results suggest that neurocognitive mechanisms associated with target detection and evaluation (Go P300) and response inhibition (NoGo P300) are compromised in persons with MCI.
University of Ottawa, School of Psychology, Vanier Hall, 136 Jean Jacques Lussier, Ottawa, ON, Canada, K1N 6N5; Bruyère Research Institute, 75 Bruyère St., Ottawa, Ontario, Canada, K1N 5C8.
Rocío A
RA
López Zunini
Bruyère Research Institute, 75 Bruyère St., Ottawa, Ontario, Canada, K1N 5C8; Bruyère Memory Program, Bruyère Continuing Care, 43 Bruyère St, Ottawa, ON, Canada, K1N 5C8; Carleton University, Faculty of Engineering and Design, 3010 The Minto Centre, 1125 Colonel By Drive, Ottawa, ON, Canada, K1S 5B6; University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, ON, Canada, K1H 8M5.
Frank
F
Knoefel
Bruyère Research Institute, 75 Bruyère St., Ottawa, Ontario, Canada, K1N 5C8.
Courtney
C
Lord
Bruyère Memory Program, Bruyère Continuing Care, 43 Bruyère St, Ottawa, ON, Canada, K1N 5C8.
Michael
M
Breau
Bruyère Research Institute, 75 Bruyère St., Ottawa, Ontario, Canada, K1N 5C8; Bruyère Memory Program, Bruyère Continuing Care, 43 Bruyère St, Ottawa, ON, Canada, K1N 5C8.
Lisa
L
Sweet
Bruyère Research Institute, 75 Bruyère St., Ottawa, Ontario, Canada, K1N 5C8; Bruyère Memory Program, Bruyère Continuing Care, 43 Bruyère St, Ottawa, ON, Canada, K1N 5C8; Carleton University, Faculty of Engineering and Design, 3010 The Minto Centre, 1125 Colonel By Drive, Ottawa, ON, Canada, K1S 5B6.
Rafik
R
Goubran
University of Ottawa, School of Psychology, Vanier Hall, 136 Jean Jacques Lussier, Ottawa, ON, Canada, K1N 6N5; Bruyère Research Institute, 75 Bruyère St., Ottawa, Ontario, Canada, K1N 5C8. Electronic address: vtaler@uottawa.ca.
Vanessa
V
Taler
D000368:Aged; D002540:Cerebral Cortex / Q000503:physiopathology*; D060825:Cognitive Dysfunction / Q000503:physiopathology*; D004569:Electroencephalography; D018913:Event-Related Potentials, P300; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D009483:Neuropsychological Tests
Executive function; Go/nogo; Mild cognitive impairment; P300; Response inhibition