Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity.
Paclitaxel, an anticancer drug, frequently causes painful peripheral neuropathy. In this study, we investigated the preventive effect of polaprezinc on paclitaxel-induced peripheral neuropathy in rats. Polaprezinc (3 mg/kg, p.o., once daily) inhibited the development of mechanical allodynia induced by paclitaxel (4 mg/kg, i.p., on days 1, 3, 5 and 7) and suppressed the paclitaxel-induced increase in macrophage migration in dorsal root ganglion cells. In addition, polaprezinc did not affect the anti-tumor activity of paclitaxel in cultured cell lines or tumor-bearing mice. These results suggest a clinical indication for polaprezinc in the prevention of paclitaxel-induced neuropathy.
Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan.
Kuniaki
K
Tsutsumi
Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan.
Takanori
T
Kaname
Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan.
Haruka
H
Shiraishi
Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan.
Takehiro
T
Kawashiri
Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan. Electronic address: n-egashi@pharm.med.kyushu-u.ac.jp.
Nobuaki
N
Egashira
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000627:therapeutic use; D002336:Carnosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D009942:Organometallic Compounds / Q000627:therapeutic use*; D017239:Paclitaxel / Q000009:adverse effects* / Q000627:therapeutic use; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D047368:Tumor Burden / Q000187:drug effects; D017967:Zinc Compounds / Q000627:therapeutic use
D000700:Analgesics; D000972:Antineoplastic Agents, Phytogenic; D009942:Organometallic Compounds; D017967:Zinc Compounds; C061957:polaprezinc; D002336:Carnosine; D017239:Paclitaxel
Paclitaxel; Peripheral neuropathy; Polaprezinc