Age-Related Changes in the System Metalloproteinases/Tissue Metalloproteinase Inhibitors and Proteoglycan Components in Mouse Organs.
Activity of MMP and content of TIMP and some proteoglycan components were measured in the liver, lungs, and spleen of BALB/c mice aging 2, 6, and 12 months. The increase in the content of proteoglycan components in mouse organs was associated with age-related changes in MMP activity and TIMP-1 and TIMP-2 levels. The ratio between MMP activity and content of TIMP-1 and TIMP-2 differed in the studied organs. The levels of TIMP-1 and TIMP-2 in mouse blood serum and their concentration in studied organs changed asynchronously with age. They are important regulators that determine MMP activity in the analyzed age periods in mice, which can be determined as periods of growth, development, and ageing.
Institute of Experimental and Clinical Medicine, Novosibirsk, Russia. lenkim@centercem.ru.
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Kim
Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.|Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.
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Shkurupy
Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
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Putyatina
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D002648:Child; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D011509:Proteoglycans / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism*; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000378:metabolism*; D055815:Young Adult
D011509:Proteoglycans; D019715:Tissue Inhibitor of Metalloproteinase-1; D019716:Tissue Inhibitor of Metalloproteinase-2; D020782:Matrix Metalloproteinases
age; matrix metalloproteinases; proteoglycans; tissue inhibitors of matrix metalloproteinases; visceral organs of mice