Recent Advances in Egypt for Treatment of Talar Osteochondral Lesions.
Treatment of osteochondral defects (OCLs) of the talus is a challenging orthopedic surgery. Treatment of talar OCLs has evolved through the 3 "R" paradigm: reconstruction, repair, and replacement. This article highlights current state-of-the-art techniques and reviews recent advances in the literature about articular cartilage repair using various novel tissue engineering approaches, including various scaffolds, growth factors, and cell niches; which include chondrocytes and culture-expanded bone marrow-derived mesenchymal stem cells.
Department of Orthopedic Surgery, Oklahoma University College of Medicine Health Sciences Center, Oklahoma City, OK, USA; Department of Orthopedic Surgery, Kasr Al-Ainy Hospital, Cairo University School of Medicine, Saray El-Manial Street, El-Manial, Cairo 12411, Egypt. Electronic address: haleem@kasralainy.edu.eg.
Amgad M
AM
Haleem
Department of Orthopedic Surgery, Kasr Al-Ainy Hospital, Cairo University School of Medicine, Saray El-Manial Street, El-Manial, Cairo 12411, Egypt; Department of Orthopedic Surgery, Albany Medical College, 1367 Washington Avenue, Albany, NY 12206, USA.
Mostafa M
MM
AbouSayed
Department of Orthopedic Surgery, Kasr Al-Ainy Hospital, Cairo University School of Medicine, Saray El-Manial Street, El-Manial, Cairo 12411, Egypt.
Mohammed
M
Gomaa
D016026:Bone Marrow Transplantation; D002358:Cartilage, Articular / Q000473:pathology / Q000601:surgery*; D019902:Chondrocytes; D004534:Egypt; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D045164:Mesenchymal Stem Cell Transplantation; D013628:Talus / Q000601:surgery*; D023822:Tissue Engineering; D054457:Tissue Scaffolds; D014182:Transplantation, Autologous
D036341:Intercellular Signaling Peptides and Proteins
Articular cartilage; Osteochondral lesions; Reconstruction; Repair; Talus; Tissue engineering