Platelets and coronary artery disease: Interactions with the blood vessel wall and cardiovascular devices.
In view of the rare presence of studies concerning platelet function as risk factor in atherosclerotic patients, processes underlying thromboembolic events are reviewed in this paper. The morphology and the structural organization-membrane receptors, the open canalicular and dense tubular systems, the cytoskeleton, mitochondria, granules, lysosomes, and peroxisomes-of platelets are described. Platelet function under physiological conditions in atherosclerosis and after implantation of cardiovascular devices is summarized.
Department for Cardiology, Charité Universitätsmedizin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany; Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies (BCRT), Helmholtz Zentrum Geesthacht, Kantstrasse 55, 14513 Teltow, Germany; and Joint Laboratory HZG/Charité-FUB, Kantstr. 55, 14513 Teltow, Germany.
Markus
M
Reinthaler
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies (BCRT), Helmholtz Zentrum Geesthacht, Kantstrasse 55, 14513 Teltow, Germany.
Steffen
S
Braune
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies (BCRT), Helmholtz Zentrum Geesthacht, Kantstrasse 55, 14513 Teltow, Germany and Joint Laboratory HZG/Charité-FUB, Kantstr. 55, 14513 Teltow, Germany.
Andreas
A
Lendlein
Department for Cardiology, Charité Universitätsmedizin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany and Joint Laboratory HZG/Charité-FUB, Kantstr. 55, 14513 Teltow, Germany.
Ulf
U
Landmesser
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies (BCRT), Helmholtz Zentrum Geesthacht, Kantstrasse 55, 14513 Teltow, Germany and Joint Laboratory HZG/Charité-FUB, Kantstr. 55, 14513 Teltow, Germany.
Friedrich
F
Jung
D001792:Blood Platelets / Q000502:physiology*; D001808:Blood Vessels / Q000473:pathology*; D002448:Cell Adhesion; D003324:Coronary Artery Disease / Q000473:pathology*; D004864:Equipment and Supplies / Q000009:adverse effects*; D006801:Humans; D013923:Thromboembolism / Q000503:physiopathology*