A Tunable Scaffold of Microtubular Graphite for 3D Cell Growth.
Aerographite (AG) is a novel carbon-based material that exists as a self-supportive 3D network of interconnected hollow microtubules. It can be synthesized in a variety of architectures tailored by the growth conditions. This flexibility in creating structures presents interesting bioengineering possibilities such as the generation of an artificial extracellular matrix. Here we have explored the feasibility and potential of AG as a scaffold for 3D cell growth employing cyclic RGD (cRGD) peptides coupled to poly(ethylene glycol) (PEG) conjugated phospholipids for surface functionalization to promote specific adhesion of fibroblast cells. Successful growth and invasion of the bulk material was followed over a period of 4 days.
Institute for Materials Science, University of Kiel , 24143 Kiel, Germany.
Constanze
C
Lamprecht
Institute for Materials Science, University of Kiel , 24143 Kiel, Germany.
Mohammadreza
M
Taale
Institute for Materials Science, University of Kiel , 24143 Kiel, Germany.
Ingo
I
Paulowicz
Institute for Materials Science, University of Kiel , 24143 Kiel, Germany.
Hannes
H
Westerhaus
Institute for Materials Science, University of Kiel , 24143 Kiel, Germany.
Carsten
C
Grabosch
Institute for Materials Science, University of Kiel , 24143 Kiel, Germany.
Arnim
A
Schuchardt
Institute of Polymers and Composites, Hamburg University of Technology , 21073 Hamburg, Germany.
Matthias
M
Mecklenburg
Institute of Anatomy, University of Kiel , 24118 Kiel, Germany.
Martina
M
Böttner
Institute of Anatomy, University of Kiel , 24118 Kiel, Germany.
Ralph
R
Lucius
Institute of Polymers and Composites, Hamburg University of Technology , 21073 Hamburg, Germany.
Karl
K
Schulte
Institute for Materials Science, University of Kiel , 24143 Kiel, Germany.
Rainer
R
Adelung
Institute for Materials Science, University of Kiel , 24143 Kiel, Germany.
Christine
C
Selhuber-Unkel
D002448:Cell Adhesion; D002478:Cells, Cultured; D006108:Graphite / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry; D011092:Polyethylene Glycols; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
D010743:Phospholipids; D011092:Polyethylene Glycols; D006108:Graphite
3D scaffold; aerographite; cyclic RGD; fibroblasts; tissue engineering