Current concepts in the diagnosis and pathobiology of intraepithelial neoplasia: A review by organ system.
Answer questions and earn CME/CNE In this report, a team of surgical pathologists has provided a review of intraepithelial neoplasia in a host of (but not all) anatomic sites of interest to colleagues in various medical specialties, namely, uterine cervix, ovary, breast, lung, head and neck, skin, prostate, bladder, pancreas, and esophagus. There is more experience with more readily accessible sites (such as the uterine cervix and skin) than with other anatomic sites, and the lack of uniform terminology, together with divergent biology in various sites, makes it difficult to paint a unifying, relevant portrait. The authors' aim was to provide a framework from which to move forward as we care for patients with such precancerous lesions. CA Cancer J Clin 2016;66:408-436. © 2016 American Cancer Society.
Assistant Professor of Pathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
Lysandra
L
Voltaggio
Assistant Professor of Pathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
Ashley
A
Cimino-Mathews
Associate Professor of Pathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
Justin A
JA
Bishop
Professor of Pathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
Pedram
P
Argani
Assistant Professor of Dermatology, Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD.
Jonathan D
JD
Cuda
Professor of Pathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.|Professor of Urology, Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD.
Jonathan I
JI
Epstein
Professor of Pathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
Ralph H
RH
Hruban
Professor of Pathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
George J
GJ
Netto
Professor of Pathology, Department of Pathology, University of Virginia Health System, Charlottesville, VA.
Mark H
MH
Stoler
Associate Professor of Dermatology and Pathology, Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD.
Janis M
JM
Taube
Professor of Pathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
Russell
R
Vang
Professor of Pathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
William H
WH
Westra
Professor of Pathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
Elizabeth A
EA
Montgomery
D000570:American Cancer Society; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D004938:Esophageal Neoplasms / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D008297:Male; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D010190:Pancreatic Neoplasms / Q000473:pathology; D011159:Population Surveillance; D011471:Prostatic Neoplasms / Q000473:pathology; D012307:Risk Factors; D012878:Skin Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D001749:Urinary Bladder Neoplasms / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000628:therapy
carcinoma in situ; dysplasia; intraepithelial neoplasia; precancer; preinvasive neoplasia