Aspirin resistance frequency in healthy males.
BACKGROUND
Aspirin has been shown to have variable antiplatelet activity in individuals. Previous studies have estimated that 5% to 45% of the population do not achieve an adequate antiplatelet effect from aspirin and still suffer ischemic events despite therapy.


OBJECTIVE
In this study, we aimed to evaluate aspirin resistance in healthy males.


METHODS
We prospectively enrolled 175 healthy males who were ≥19 years old and taking 100 mg of aspirin daily ≥7 consec¬utive days before study entry. Demographic information and laboratory data were collected. Aspirin resistance was detected by optical platelet aggregometry, a widely accepted method using adenosine diphosphate (ADP) and arachidonic acid (AA).


RESULTS
28% of the participants were aspirin-resistant, 62% were aspirin-semi-responders and 10% were aspirin-sensitive. The aspirin-resistant individuals were older than the semi-responders (p<0.01), and had higher erythrocyte sedimentation rate than the semi-responders (p<0.01) and sensitive individuals (p<0.05).


CONCLUSIONS
Our study demonstrates aspirin resistance to be particularly important given its high frequency in our study population. The biological effects of aspirin, which is widely used as an antithrombotic drug, are not similar in all individuals.
Division of Rheumatology, Department of Internal Medicine, Eskiflehir Osmangazi University, Eskiflehir, Turkey, Tel: +90 222 239 29 79-2925 E-mail: ducansu@hotmail.com.
Döndü
D
Üsküdar Cansu
Olga Meltem
OM
Akay
Zerrin
Z
Cantürk
Zafer
Z
Gülbaş