Isolation of KPC 3-producing Enterobacter aerogenes in a patient colonized by MDR Klebsiella pneumoniae.
We describe the interspecies transmission of the plasmid-mediated blaKPC-3 gene, which confers carbapenem resistance, between clinically relevant gram-negative bacteria in a single patient. A KPC-3 producing Enterobacter aerogenes was isolated from a hospitalized patient previously colonized and then infected by a Klebsiella pneumoniae ST101 carrying the blaKPC-3 gene. The strains showed identical plasmids. Since intense horizontal exchanges among bacteria can occur in the gut, clinicians should be aware that patients colonized by carbapenem-resistant K. pneumoniae could become carriers of other carbapenem-resistant Enterobacteriaceae.
National Institute for Infectious Diseases (INMI) L. Spallanzani, Rome, Italy.
Carolina
C
Venditti
Department of 7 Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
Laura
L
Villa
National Institute for Infectious Diseases (INMI) L. Spallanzani, Rome, Italy.
Alessandro
A
Capone
Department of 7 Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
Daniela
D
Fortini
National Institute for Infectious Diseases (INMI) L. Spallanzani, Rome, Italy.
Silvia
S
D'Arezzo
National Institute for Infectious Diseases (INMI) L. Spallanzani, Rome, Italy.
Carla
C
Nisii
National Institute for Infectious Diseases (INMI) L. Spallanzani, Rome, Italy.
Eugenio
E
Bordi
National Institute for Infectious Diseases (INMI) L. Spallanzani, Rome, Italy.
Vincenzo
V
Puro
National Institute for Infectious Diseases (INMI) L. Spallanzani, Rome, Italy.
Mario
M
Antonini
Department of 7 Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
Alessandra
A
Carattoli
National Institute for Infectious Diseases (INMI) L. Spallanzani, Rome, Italy.
Maria Adriana
MA
Cataldo
National Institute for Infectious Diseases (INMI) L. Spallanzani, Rome, Italy.
Nicola
N
Petrosillo
National Institute for Infectious Diseases (INMI) L. Spallanzani, Rome, Italy.
Antonino
A
Di Caro
D001426:Bacterial Proteins / Q000235:genetics*; D021902:Enterobacter aerogenes / Q000235:genetics*; D022761:Gene Transfer, Horizontal; D006801:Humans; D007711:Klebsiella pneumoniae / Q000235:genetics*; D008297:Male; D010957:Plasmids; D001618:beta-Lactamases / Q000235:genetics*
D001426:Bacterial Proteins; D001618:beta-Lactamases; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae
Galactomannan antigen; MALDI-TOF identification; Magnusiomyces capitatus; Pleural infection; Posaconazole