Cell Biology: ERADicating Survival with BOK.
Mechanistic insights into the function of the pro-apoptotic BCL-2 family member BOK have remained elusive. A recent study shows that healthy cells constitutively degrade BOK via the ER-associated degradation and ubiquitin-proteasome pathways; following proteasome inhibition, BOK is stabilized to initiate a unique pro-apoptotic death program.
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: jerry.chipuk@mssm.edu.
Jerry Edward
JE
Chipuk
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Mark P
MP
Luna-Vargas
D017209:Apoptosis; D060746:Endoplasmic Reticulum-Associated Degradation; D006801:Humans; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*
C503049:BOK protein, human; D019253:Proto-Oncogene Proteins c-bcl-2