An unusual case of congenital cytomegalovirus infection-related retinopathy.
BACKGROUND
Cytomegalovirus (CMV) is the most common congenital infection, and chorioretinitis is the most common ophthalmic manifestation of congenital CMV infection. We experienced a unique case of CMV retinopathy showing unusual retinal vessels.


METHODS
An infant boy weighing 1860 g was born at 36 weeks. He was diagnosed with severe symptomatic congenital CMV infection, which was confirmed by positive CMV-DNA in urine and whole blood, and he was referred to our ophthalmology department on his first day of life. Ophthalmoscopic examination and fluorescein angiography revealed no chorioretinitis but major retinal vascular occlusions and arterio-venous anastomosis associated with CMV detection in the aqueous humor. These findings regressed within a week after treatment with systemic gancyclovir administration.


CONCLUSIONS
To our knowledge, there are no reports of these ocular issues associated with congenital CMV infection. These findings may be useful for the early and rapid diagnosis of congenital CMV infection.
Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Mizuki
M
Tagami
Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. sighonda@med.kobe-u.ac.jp.
Shigeru
S
Honda
Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Ichiro
I
Morioka
Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
Kazumoto
K
Iijima
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.
Hideto
H
Yamada
Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Makoto
M
Nakamura
D000998:Antiviral Agents / Q000627:therapeutic use; D017726:Cytomegalovirus Retinitis / Q000151:congenital / Q000175:diagnosis*; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016896:Treatment Outcome
D000998:Antiviral Agents; D015774:Ganciclovir
Congenital cytomegalovirus; Neonate; Retinal arteriovenous anastomosis