A novel HLA-B allele, HLA-B*35:279, identified by sequencing-based typing in a Czech patient.
The identification of a novel HLA-B*35:279 allele in a Czech patient is described. This allele is identical to the B*35:03:01 variant except the G/A nucleotide exchange at position 652 of the HLA-B gene that corresponds to the amino acid substitution from valine to isoleucine in alpha 3 domain of the HLA-B antigen.
Department of Immunology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
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F
Mrazek
Department of Immunology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
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J
Onderkova
Department of Immunology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
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N
Königova
Department of HLA, Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
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V
Siffnerova
Department of HLA, Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
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M
Vrana
Department of Immunology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
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Z
Ambruzova
Department of Hemato-Oncology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
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I
Skoumalova
Department of Immunology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
M
M
Petrek
Department of Hemato-Oncology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
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L
Raida
D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D018153:Czech Republic; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology* / Q000302:isolation & purification; D006650:Histocompatibility Testing; D006801:Humans
D015235:HLA-B Antigens