Metastatic Granulosa Cell Tumor of the Testis: Clinical Presentation and Management.
Granulosa cell tumors (GCTs) of the testis are rare sex cord-stromal tumors that are present in both juvenile and adult subtypes. While most adult GCTs are benign, those that present with distant metastases manifest a grave prognosis. Treatments for aggressive GCTs are not well established. Options that have been employed in previous cases include retroperitoneal lymph node dissection (RPLND), radiation, chemotherapy, or a combination thereof. We describe the case of a 57-year-old man who presented with a painless left testicular mass and painful gynecomastia. Serum tumor markers (alpha fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase) and computed tomography of the chest and abdomen were negative. The patient underwent left radical orchiectomy. Immunohistochemical staining was consistent with a testicular GCT. He underwent a left-template laparoscopic RPLND which revealed 2/19 positive lymph nodes. Final pathological stage was IIA. He remains free of disease 32 months after surgery.
Division of Urologic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Anand
0000-0003-4488-6918
A
Mohapatra
Division of Urologic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Aaron M
0000-0003-4619-1773
AM
Potretzke
Division of Urologic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Brent A
0000-0003-2864-1347
BA
Knight
Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Min
M
Han
Division of Urologic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Robert S
RS
Figenshau