The Association of CYP1A1 Gene With Cervical Cancer and Additional SNP-SNP Interaction in Chinese Women.
OBJECTIVE
The aim of this study was to investigate the association between CYP1A1 gene polymorphism and cervical cancer risk, and the impact of SNP-SNP interaction on cervical cancer risk in Chinese women.


METHODS
A total of 728 females with a mean age of 60.1 ± 14.5 years old were selected, including 360 cervical cancer patients and 368 normal controls. Logistic regression was performed to investigate association between single-nucleotide polymorphisms (SNP) and cervical cancer risk. Generalized multifactor dimensionality reduction (GMDR) was used to analyze the SNP-SNP interaction.


RESULTS
Logistic analysis showed a significant association between rs4646903 and increased cervical cancer risk. The carriers of homozygous mutant of rs4646903 polymorphism revealed increased cervical cancer risk than those with wild-type homozygotes, OR (95%CI) were 1.45 (1.20-1.95). There was a significant two-locus model (P = 0.0107) involving rs4646903 and rs1048943, indicating a potential SNP-SNP interaction between rs4646903 and rs1048943. Overall, the two-locus models had a cross-validation consistency of 10 of 10, and had the testing accuracy of 60.72%. Subjects with TC or CC of rs4646903 and AG or GG of rs1048943 genotype have the highest cervical cancer risk, compared to subjects with TT of rs4646903 and AA of rs1048943 genotype, OR (95%CI) was 2.03 (1.42-2.89).


CONCLUSIONS
rs4646903 minor alleles and interaction between rs4646903 and rs1048943 were associated with increased cervical cancer risk.
Department of Obstetrics and Gynecology, Yantai Yuhuangding Hospital, Yantai, China.
Shuhong
S
Li
Department of Obstetrics and Gynecology, Yantai Yuhuangding Hospital, Yantai, China.
Guiqin
G
Li
Emergency Department, Yantai Yuhuangding Hospital, Yantai, China.
Fanqiang
F
Kong
Department of Obstetrics and Gynecology, Yantai Yuhuangding Hospital, Yantai, China.
Zhifen
Z
Liu
Central Laboratory, Yantai Yuhuangding Hospital, Yantai, China.
Ning
N
Li
Central Laboratory, Yantai Yuhuangding Hospital, Yantai, China.
Yan
Y
Li
Department of Reproductive Medicine, Affiliated Hospital of Medical College, Qingdao University, Qingdao, China. guoxjxj8826@sina.com.
Xiaojing
X
Guo
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002681:China; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1
CYP1A1; cancer risk; interaction; polymorphism