Recovery of a 10-year-old girl from methicillin-resistant Staphylococcus aureus sepsis in response to low-dose ceftaroline treatment.
A 9-year-old girl was severely injured in a car accident in Afghanistan, in which both her lower legs were badly damaged. She was treated at the Hospital of Ingolstadt (Klinikum Ingolstadt) after she had undergone initial surgery at an Indian hospital. Various bacterial species were isolated from multiple wounds, and methicillin-resistant Staphylococcus aureus (MRSA) was one among them. After the amputation of her lower legs, she developed MRSA sepsis, which was successfully treated with a relatively low dosage of ceftaroline (Zinforo(®)/Teflaro(®); 2×9 mg/kg/d), although the bacterial isolate's minimal inhibitory concentration (1.5-4 mg/L) suggested a decreased susceptibility. In summary, ceftaroline was highly efficient and well tolerated by the patient suffering from MRSA sepsis.
Department of Infectious Diseases and Infection Control, Klinikum Ingolstadt, Ingolstadt, Germany.
Stefan
S
Borgmann
Department of Infectious Diseases and Infection Control, Klinikum Ingolstadt, Ingolstadt, Germany.
Beate
B
Rieß
Department of Anaesthesiology and Intensive Care Medicine, Klinikum Ingolstadt, Ingolstadt, Germany.
Thomas
T
von Wernitz-Keibel
Department of Trauma Surgery, Klinikum Ingolstadt, Ingolstadt, Germany.
Matthias
M
Bühler
National Reference Centre for Staphylococci and Enterococci, Division Nosocomial Pathogens and Antibiotic Resistances, Department for Infectious Diseases, Robert Koch Institute, Wernigerode Branch, Wernigerode, Germany.
Franziska
F
Layer
National Reference Centre for Staphylococci and Enterococci, Division Nosocomial Pathogens and Antibiotic Resistances, Department for Infectious Diseases, Robert Koch Institute, Wernigerode Branch, Wernigerode, Germany.
Birgit
B
Strommenger
ceftaroline; minimal inhibitory concentration; side effects; susceptibility; therapy