[Disseminated fungal infection due to Magnusiomyces capitatus in a liver graft patient].
Disseminated fungal infections due to Magnusiomyces capitatus are rare, occurring exclusively in immunocompromised patients. We report the first case in a liver transplant patient with chronic rejection and portal thrombosis who had a M. capitatus fungemia with a refractory septic shock. Despite an antibacterial and antifungal treatment with caspofungin empirical treatment, the patient died from multiple organ failure. Subsequently, mycological examinations of blood cultures, bronchoalveolar lavage fluid and urine were positive to M. capitatus identified by mass spectrometry and confirmed by sequencing respectively. The stain was resistant to caspofungin and fluconazole. The best treatment appears to be the combination of amphotericin B and voriconazole or amphotericin B and 5 fluorocytosine.
Laboratoire de parasitologie-mycologie, hôpital de l'Archet 2, centre hospitalier universitaire de Nice, 151, route Saint-Antoine-de-Ginestière, CS 23079, 06202 Nice cedex 3, France. Electronic address: kouadiocha@yahoo.fr.
C G
CG
Yapo-Kouadio
Laboratoire de parasitologie-mycologie, hôpital de l'Archet 2, centre hospitalier universitaire de Nice, 151, route Saint-Antoine-de-Ginestière, CS 23079, 06202 Nice cedex 3, France.
L
L
Hasseine
Unité de réanimation médico-chirurgicale et transplantations d'organes, hôpital de l'Archet 2, centre hospitalier universitaire de Nice, 151, route Saint-Antoine-de-Ginestière, 06202 Nice cedex 3, France.
B
B
Goubaux
Laboratoire de parasitologie-mycologie, hôpital de l'Archet 2, centre hospitalier universitaire de Nice, 151, route Saint-Antoine-de-Ginestière, CS 23079, 06202 Nice cedex 3, France.
M
M
Gari-Toussaint
D017809:Fatal Outcome; D016469:Fungemia / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology*; D006084:Graft Rejection / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D004718:Saccharomycetales / Q000302:isolation & purification*; D018805:Sepsis / Q000150:complications / Q000382:microbiology
Caspofungine; Disseminated fungal infection; Geotrichum; Infection fongique disséminée; Magnusiomyces capitatus; Transplantation hépatique; Transplanted liver