Manganese doped-iron oxide nanoparticle clusters and their potential as agents for magnetic resonance imaging and hyperthermia.
A simple, one pot method to synthesize water-dispersible Mn doped iron oxide colloidal clusters constructed of nanoparticles arranged into secondary flower-like structures was developed. This method allows the successful incorporation and homogeneous distribution of Mn within the nanoparticle iron oxide clusters. The formed clusters retain the desired morphological and structural features observed for pure iron oxide clusters, but possess intrinsic magnetic properties that arise from Mn doping. They show distinct performance as imaging contrast agents and excellent characteristics as heating mediators in magnetic fluid hyperthermia. It is expected that the outcomes of this study will open up new avenues for the exploitation of doped magnetic nanoparticle assemblies in biomedicine.
Department of Chemical and Geological Sciences and INSTM, University of Cagliari, 09042 Monserrato, Italy.
Maria F
MF
Casula
Department of Chemical and Geological Sciences and INSTM, University of Cagliari, 09042 Monserrato, Italy.
Erika
E
Conca
Institute for Life Sciences, Physics and Astronomy, Faculty of Physical Sciences and Engineering, University of Southampton, Southampton, SO17 1BJ, UK. a.kanaras@soton.ac.uk.
Ioanna
I
Bakaimi
Istituto Italiano di Tecnologia, via Morego 30, 16145 Genoa, Italy.
Ayyappan
A
Sathya
Istituto Italiano di Tecnologia, via Morego 30, 16145 Genoa, Italy.
Maria Elena
ME
Materia
Biological and Environmental Science and Engineering Division, KAUST, Jeddah, Saudi Arabia.
Alberto
A
Casu
Biological and Environmental Science and Engineering Division, KAUST, Jeddah, Saudi Arabia.
Andrea
A
Falqui
Biological and Environmental Science and Engineering Division, KAUST, Jeddah, Saudi Arabia.
Elisa
E
Sogne
Istituto Italiano di Tecnologia, via Morego 30, 16145 Genoa, Italy.
Teresa
T
Pellegrino
Institute for Life Sciences, Physics and Astronomy, Faculty of Physical Sciences and Engineering, University of Southampton, Southampton, SO17 1BJ, UK. a.kanaras@soton.ac.uk.
Antonios G
AG
Kanaras