The relationship between seizures, interictal spikes and antiepileptic drugs.
A considerable decrease in spike rate accompanies antiepileptic drug (AED) taper during intracranial EEG (icEEG) monitoring. Since spike rate during icEEG monitoring can be influenced by surgery to place intracranial electrodes, we studied spike rate during long-term scalp EEG monitoring to further test this observation.



We analyzed spike rate, seizure occurrence and AED taper in 130 consecutive patients over an average of 8.9days (range 5-17days).



We observed a significant relationship between time to the first seizure, spike rate, AED taper and seizure occurrence (F (3,126)=19.77, p<0.0001). A high spike rate was related to a longer time to the first seizure. Further, in a subset of 79 patients who experienced seizures on or after day 4 of monitoring, spike rate decreased initially from an on- to off-AEDs epoch (from 505.0 to 382.3 spikes per hour, p<0.00001), and increased thereafter with the occurrence of seizures.



There is an interplay between seizures, spikes and AEDs such that spike rate decreases with AED taper and increases after seizure occurrence.



The direct relationship between spike rate and AEDs and between spike rate and time to the first seizure suggests that spikes are a marker of inhibition rather than excitation.
Comprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA.
Irina I
II
Goncharova
Comprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA.
Rafeed
R
Alkawadri
Comprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA.
Nicolas
N
Gaspard
Comprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.
Robert B
RB
Duckrow
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.
Dennis D
DD
Spencer
Comprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA.
Lawrence J
LJ
Hirsch
Comprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.
Susan S
SS
Spencer
Comprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: Hitten.Zaveri@yale.edu.
Hitten P
HP
Zaveri
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D000069279:Drug Resistant Epilepsy / Q000188:drug therapy* / Q000503:physiopathology*; D004569:Electroencephalography / Q000187:drug effects / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000188:drug therapy* / Q000503:physiopathology*; D055815:Young Adult
D000927:Anticonvulsants
Antiepileptic drugs; EEG; Epilepsy; Epilepsy monitoring; Interictal spikes; Seizures