Characteristic of the Oxidative Stress in Blood of Patients in Dependence of Community-Acquired Pneumonia Severity.
BACKGROUND
At the present time the alternation of the oxidative metabolism is considered as one of the leading pathogenic mechanisms in the development and progression of community-acquired pneumonia (CAP). However the nature and direction of the oxidative protein changes in CAP patient's blood had been almost unexplored.


OBJECTIVE
To define oxidative and modified proteins in erythrocytes and blood plasma of CAP patients.


METHODS
Blood plasma and erythrocytes obtained from: 42 patients with moderate severity pneumonia, 12 patients with grave severity pneumonia and 32 healthy volunteers. Content of advanced oxidation protein products, malondialdehyde and reactive carbonyl derivatives were estimated as indicators of the oxidative stress and oxidative damage of proteins.


RESULTS
In patients with grave severity the level of oxidative proteins and MDA in erythrocytes exceeded both: control values and similar meanings in CAP patients with moderate severity. The further growth of MDA in this group patients' blood plasma was observed, but the level of oxidative proteins decreased in comparison with those in CAP patients with moderate severity.


CONCLUSIONS
To sum up, our derived data show, that injury of erythrocytes' redox-status and blood plasma components plays an essential role in development and progression CAP.
State Medical University, Biological Chemistry, Karaganda 100008, Kazakhstan.
Larissa
L
Muravlyova
State Medical University, Propaedeutics of Internal Diseases, Karaganda 100008, Kazakhstan.
Vilen
V
Molotov-Luchankiy
State Medical University, Propaedeutics of Internal Diseases, Karaganda 100008, Kazakhstan.
Ryszhan
R
Bakirova
State Medical University, Biological Chemistry, Karaganda 100008, Kazakhstan.
Dmitriy
D
Klyuyev
State Medical University, Biological Chemistry, Karaganda 100008, Kazakhstan.
Ludmila
L
Demidchik
State Medical University, Propaedeutics of Internal Diseases, Karaganda 100008, Kazakhstan.
Valentina
V
Lee
blood plasma; community-acquired pneumonia; erythrocytes; malondialdehyde; modified proteins