Ticagrelor versus prasugrel in patients with high on-clopidogrel treatment platelet reactivity after PCI: The ISAR-ADAPT-PF study.
Patients with high on-treatment platelet reactivity (HTPR) on clopidogrel are at high risk for adverse cardiovascular events after percutaneous coronary intervention (PCI). The aim of the ISAR-ADAPT-PF study was to assess the antiplatelet efficacy of ticagrelor versus prasugrel in patients with HTPR on clopidogrel. In a prospective and randomized clinical study, 70 patients with HTPR on clopidogrel loading dose (LD) within 24 h post PCI were assigned to receive either ticagrelor [180 mg LD followed by 90 mg maintenance dose (MD) twice daily] or prasugrel (60 mg LD followed by 10 mg MD once daily). The adenosine diphosphate-induced platelet aggregation assessed on the Multiplate analyzer on day 2 after randomization (primary end point) was as follows: the mean difference between the two treatment groups was 6 aggregation units (AU) × min with an upper 95% confidence interval (CI) of 41 AU × min, which was greater than the predefined noninferiority margin of 18 AU × min (P for noninferiority = 0.29). However, no significant differences in absolute platelet reactivity levels between ticagrelor- versus prasugrel-treated patients at that time point were observed (138 ± 100 AU × min vs. 132 ± 64 AU × min, P for superiority = 0.77). In conclusion, neither drug was statistically more effective for inhibition of platelet aggregation in patients with HTPR on clopidogrel post PCI, although the study could not formally demonstrate the assumed noninferiority of ticagrelor versus prasugrel.
a Medizinische Klinik und Poliklinik, Klinikum rechts der Isar , Technische Universität München , Munich , Germany.
Isabell
I
Bernlochner
b Deutsches Herzzentrum München , Technische Universität München , Munich , Germany.
Katharina
K
Mayer
c Department of Cardiology , Ludwig-Maximilians-Universität , Munich , Germany.
Martin
M
Orban
b Deutsches Herzzentrum München , Technische Universität München , Munich , Germany.
Tanja
T
Morath
a Medizinische Klinik und Poliklinik, Klinikum rechts der Isar , Technische Universität München , Munich , Germany.
Juliane
J
Jaitner
a Medizinische Klinik und Poliklinik, Klinikum rechts der Isar , Technische Universität München , Munich , Germany.
Lisa
L
Rössner
c Department of Cardiology , Ludwig-Maximilians-Universität , Munich , Germany.
Lisa
L
Gross
a Medizinische Klinik und Poliklinik, Klinikum rechts der Isar , Technische Universität München , Munich , Germany.|d DZHK (German Centre for Cardiovascular Research) , partner site Munich Heart Alliance , Munich , Germany.
Karl-Ludwig
KL
Laugwitz
b Deutsches Herzzentrum München , Technische Universität München , Munich , Germany.|d DZHK (German Centre for Cardiovascular Research) , partner site Munich Heart Alliance , Munich , Germany.
Adnan
A
Kastrati
c Department of Cardiology , Ludwig-Maximilians-Universität , Munich , Germany.|d DZHK (German Centre for Cardiovascular Research) , partner site Munich Heart Alliance , Munich , Germany.
Dirk
D
Sibbing
D000241:Adenosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000368:Aged; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism*; D000077144:Clopidogrel; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000097:blood / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects; D015539:Platelet Activation / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D010979:Platelet Function Tests; D000068799:Prasugrel Hydrochloride / Q000008:administration & dosage*; D058921:Purinergic P2Y Receptor Antagonists / Q000008:administration & dosage; D012307:Risk Factors; D000077486:Ticagrelor; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016896:Treatment Outcome
D010975:Platelet Aggregation Inhibitors; D058921:Purinergic P2Y Receptor Antagonists; D000244:Adenosine Diphosphate; D000077144:Clopidogrel; D000068799:Prasugrel Hydrochloride; D000077486:Ticagrelor; D000241:Adenosine; D013988:Ticlopidine
Clopidogrel; high on-treatment platelet reactivity; prasugrel; ticagrelor