Acoustic Radiation Force Optical Coherence Elastography of Corneal Tissue.
We report on a real-time acoustic radiation force optical coherence elastography (ARF-OCE) system to map the relative elasticity of corneal tissue. A modulated ARF is used as excitation to vibrate the cornea while OCE serves as detection of tissue response. To show feasibility of detecting mechanical contrast using this method, we performed tissue-equivalent agarose phantom studies with inclusions of a different stiffness. We obtained 3-D elastograms of a healthy cornea and a highly cross-linked cornea. Finally we induced a stiffness change on a small portion of a cornea and observed the differences in displacement.
Department of Biomedical Engineering, the Edwards Life Sciences Center for Advanced Cardiovascular Technology, and Beckman Laser Institute, University of California, Irvine, Irvine, CA 92697 USA.
Yueqiao
Y
Qu
NIH Ultrasonic Transducer Resource Center and the Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Teng
T
Ma
Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612 USA.
Youmin
Y
He
Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612 USA.
Jiang
J
Zhu
Beckman Laser Institute, University of California, Irvine, Irvine, CA 92612 USA, and the Shanghai Institute of Technology, 100 Haiquan Road, Fengxian, Shanghai, China.
Cuixia
C
Dai
NIH Ultrasonic Transducer Resource Center and the Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Mingyue
M
Yu
Beckman Laser Institute, University of California, Irvine, Irvine 92612 USA and the School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 325027 China.
Shenghai
S
Huang
School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 325027 China.
Fan
F
Lu
NIH Ultrasonic Transducer Resource Center and the Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
K Kirk
KK
Shung
NIH Ultrasonic Transducer Resource Center and the Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Qifa
Q
Zhou
Department of Biomedical Engineering, the Edwards Life Sciences Center for Advanced Cardiovascular Technology, and Beckman Laser Institute, University of California, Irvine, Irvine, CA 92697 USA.
Zhongping
Z
Chen
ARF; OCT; cornea; elastography