LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204.
Accumulating evidence indicates that the lncRNAs play a critical role in cancer progression and metastasis. In this study, we found that MALAT1 upregulation was associated with larger tumor size and lymph-node metastasis, and also correlated with shorter overall survival of lung adenocarcinoma patients. Furthermore, MALAT1 promotes EMT and metastasis of lung adenocarcinoma cells in vitro and in vivo. In particular, MALAT1 upregulated the expression of miR-204 target gene SLUG through competitively 'spongeing' miR-204. In summary we unveil a branch of the MALAT1/miR-204/SLUG pathway that regulates the progression of lung adenocarcinoma.
Department of Central Laboratory, Yinzhou People's Hospital Ningbo 315040, China.
Jipeng
J
Li
Department of Central Laboratory, Yinzhou People's Hospital Ningbo 315040, China.
Jianhua
J
Wang
Department of Central Laboratory, Yinzhou People's Hospital Ningbo 315040, China.
Yin
Y
Chen
Department of Central Laboratory, Yinzhou People's Hospital Ningbo 315040, China.
Shanfeng
S
Li
Department of Central Laboratory, Yinzhou People's Hospital Ningbo 315040, China.
Mingwei
M
Jin
Department of Respiratory and Critical Care Medicine, Yinzhou People's Hospital Ningbo 315040, China.
Huaying
H
Wang
Department of Central Laboratory, Yinzhou People's Hospital Ningbo 315040, China.
Zhe
Z
Chen
Department of Respiratory and Critical Care Medicine, Yinzhou People's Hospital Ningbo 315040, China.
Wanjun
W
Yu
Lung adenocarcinoma; MALAT1; SLUG; miR-204