Red blood cell-derived microparticles: An overview.
The red blood cell (RBC) is historically the original parent cell of microparticles (MPs). In this overview, we describe the discovery and the early history of red cell-derived microparticles (RMPs) and present an overview of the evolution of RMP. We report the formation, characteristics, effects of RMP and factors which may affect RMP evaluation. The review examines RMP derived from both normal and pathologic RBC. The pathologic RBC studies include sickle cell anemia (SCA), sickle cell trait (STr), thalassemia intermedia (TI), hereditary spherocytosis (HS), hereditary elliptocytosis (HE), hereditary stomatocytosis (HSt) and glucose-6-phosphate dehydrogenase deficiency (G6PD).
Mount Sinai Hospital, 1500 South California Avenue, Chicago, IL 60608, United States. Electronic address: max.westerman@sinai.org.
Maxwell
M
Westerman
Department of Haematology, University College London, 72 Huntley Street, London N I 4Pz, UK.
John B
JB
Porter
D055252:Cell-Derived Microparticles / Q000473:pathology*; D004912:Erythrocytes / Q000166:cytology / Q000473:pathology*; D006402:Hematologic Diseases / Q000473:pathology; D006801:Humans
Overview; Red blood cell-derived microparticles