High-energy proton imaging for biomedical applications.
The charged particle community is looking for techniques exploiting proton interactions instead of X-ray absorption for creating images of human tissue. Due to multiple Coulomb scattering inside the measured object it has shown to be highly non-trivial to achieve sufficient spatial resolution. We present imaging of biological tissue with a proton microscope. This device relies on magnetic optics, distinguishing it from most published proton imaging methods. For these methods reducing the data acquisition time to a clinically acceptable level has turned out to be challenging. In a proton microscope, data acquisition and processing are much simpler. This device even allows imaging in real time. The primary medical application will be image guidance in proton radiosurgery. Proton images demonstrating the potential for this application are presented. Tomographic reconstructions are included to raise awareness of the possibility of high-resolution proton tomography using magneto-optics.
GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany.
M
M
Prall
GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany.|Technische Universität Darmstadt, Schlossgartenstraße 9, 64289 Darmstadt, Germany.
M
M
Durante
Deutsches Zentrum für Luft- und Raumfahrt (DLR), Lindner Höhe, 51147 Cologne, Germany.
T
T
Berger
Deutsches Zentrum für Luft- und Raumfahrt (DLR), Lindner Höhe, 51147 Cologne, Germany.
B
B
Przybyla
GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany.
C
C
Graeff
GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany.|Technische Universität Darmstadt, Schlossgartenstraße 9, 64289 Darmstadt, Germany.
P M
PM
Lang
Brookhaven National Laboratory, P. O. Box 5000, Upton, NY 11973-5000, USA.
C
C
LaTessa
GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany.|Technische Universität Darmstadt, Schlossgartenstraße 9, 64289 Darmstadt, Germany.|Frankfurt Institute for Advanced Studies (FIAS), Ruth-Moufang-Straße 1, 60438 Frankfurt am Main, Germany.
L
L
Shestov
GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany.
P
P
Simoniello
Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
C
C
Danly
Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
F
F
Mariam
Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
F
F
Merrill
Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
P
P
Nedrow
Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
C
C
Wilde
GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstraße 1, 64291 Darmstadt, Germany.
D
D
Varentsov
D000818:Animals; D002645:Chickens; D006801:Humans; D008853:Microscopy / Q000379:methods / Q000592:standards; D019047:Phantoms, Imaging; D011522:Protons; D014054:Tomography / Q000379:methods* / Q000592:standards; D015027:Zebrafish
D011522:Protons