Cardiovascular Autonomic Neuropathy and Early Atherosclerosis in Adolescent Type 1 Diabetic Patient.
OBJECTIVE
To evaluate cardiovascular autonomic neuropathy (CAN) in type 1 Diabetics and to detect its relation to coronary artery calcification.


METHODS
It is a cross sectional study included 62 diabetics and 30 controls. Clinical, laboratory assessment and 24 Hr holter were done for all patients and controls and coronary artery calcium (CAC) scoring by multisclice CT was done for all patients only. T-test, Mann Whitney U test, and stepwise multiple regression were used for statistical analyses.


RESULTS
CAC score was positive in 8.1 % of patients. Heart rate variability (HRV) was significantly lower in diabetics. All parameters of HRV were insignificantly lower in diabetics with positive CAC score. Patients with microalbuminuria had a significantly lower HRV. HRV had a significant correlation with age of patients, duration of disease, HbA1, and Qtc in diabetics.


CONCLUSIONS
Percentage of arrhythmia and early atherosclerosis is high in adolescent type 1 diabetic patients. CAN is associated with early atherosclerosis. Cardiac autonomic neuropathy is associated with older age, longer duration, and poor glycemic control and microalbuminuria.
Pediatrics Department, National Research Centre, Cairo, Egypt.
Soha M Abd El
SM
Dayem
Critical Care Department, Cairo University, Cairo, Egypt.
Ahmed A
AA
Battah
Radiology Department, Cairo University, Cairo, Egypt.
Abo El Magd El
Ael M
Bohy
Cardiovascular autonomic neuropathy; coronary calcification; type 1 diabetic patient