Data on clinical significance of GAS2 in colorectal cancer cells.
The growth arrest-specific 2 (GAS2) was cloned and found to be upregulated in the feces of recurrent CRC patients. This overexpressed GAS2 induced different patterns of gene expressions in CRC cells. Briefly, one cell proliferation marker, Ki-67 antigen (Ki-67), was upregulated in the cells with overexpressed GAS2, "Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer" [1]. Whereas, the expression of another cell proliferation marker, proliferating cell nuclear antigen (PCNA), changed insignificantly [1]. In addition, the mRNA level of one cyclin involving in both cell cycle G1/S and G2/M transitions was also not affected by GAS2 overexpression, "Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A" [2]. The experimental design and procedures in this article can be helpful for understanding the molecular significance of GAS2 in SW480 and SW620 CRC cells.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chun-Chao
CC
Chang
School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan; Breast Center, Cathay General Hospital, Taipei, Taiwan; School of Medicine, Taipei Medical University, Taipei, Taiwan.
Chi-Cheng
CC
Huang
Department of Surgery, Taipei-Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming University, Taipei, Taiwan.
Shung-Haur
SH
Yang
School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan; Department of Anesthesiology, Cathay General Hospital, Taipei, Taiwan.
Chih-Cheng
CC
Chien
School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan; Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan.
Chia-Long
CL
Lee
Department of Medical Research, Cathay General Hospital, Taipei, Taiwan; Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan.
Chi-Jung
CJ
Huang