Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer.
DNAJB6 also known as mammalian relative of DnaJ (MRJ) encodes a highly conserved member of the DnaJ/Hsp40 family of co-chaperone proteins that function with Hsp70 chaperones. DNAJB6 is widely expressed in all tissues, with higher expression levels detected in the brain. DNAJB6 is involved in diverse cellular functions ranging from murine placental development, reducing the formation and toxicity of mis-folded protein aggregates, to self-renewal of neural stem cells. Involvement of DNAJB6 is implicated in multiple pathologies such as Huntington's disease, Parkinson's diseases, limb-girdle muscular dystrophy, cardiomyocyte hypertrophy and cancer. This review summarizes the important involvement of the spliced isoforms of DNAJB6 in various pathologies with a specific focus on the emerging roles of human DNAJB6 in cancer and the underlying molecular mechanisms.
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.|Beijing DOING Biomedical Technology Co. Ltd., Beijing,China.
Erhong
E
Meng
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.|Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Lalita A
LA
Shevde
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.|Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Rajeev S
RS
Samant
D050956:HSP40 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000378:metabolism
C485565:DNAJB6 protein, human; D050956:HSP40 Heat-Shock Proteins; D018832:Molecular Chaperones; D009419:Nerve Tissue Proteins; D020033:Protein Isoforms
DNAJB6; cancer; chaperone