68Ga-DOTATATE Breast Uptake and Expression in Breast Milk.
The excretion of Ga-DOTA-Octreotate (DOTATATE) and related somatostatin analogues in breast milk has not been demonstrated. We report a case of a 34-year-old woman, 7 months postpartum and breastfeeding, who was referred for DOTATATE imaging after the diagnosis of appendiceal carcinoid and subsequent appendectomy. Prominent breast uptake was noted. A breast milk sample from the patient at 90 minutes postinjection was assayed in a gamma counter and shown to have a concentration of 5.6 Bq/g per MBq administered. The excretion of DOTATATE in breast milk is important to consider when providing radiation safety advice to breastfeeding patients.
From the *Department of Nuclear Medicine, Royal North Shore Hospital, Sydney; †Faculty of Health Science, University of Sydney; ‡Northern Clinical School, University of Sydney; and §Department of Medical Oncology, Royal North Shore Hospital, Sydney, Australia.
Nicholas J
NJ
Forwood
Gowri L
GL
Kanthan
Dale L
DL
Bailey
David L
DL
Chan
Geoffrey P
GP
Schembri
D000328:Adult; D005260:Female; D006801:Humans; D042361:Mammary Glands, Human / Q000378:metabolism* / Q000528:radiation effects; D008895:Milk, Human / Q000528:radiation effects*; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D049268:Positron-Emission Tomography / Q000009:adverse effects*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*
D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C513399:gallium Ga 68 dotatate