Serum apelin is associated with affective disorders in peritoneal dialysis patients.
OBJECTIVE
Depression and anxiety are prevalent affective disorders in peritoneal dialysis (PD) patients. Recent research has proposed a potential role of apelinergic system in pathogenesis of depression. The present study aimed to evaluate the frequency of depression and anxiety and their potential relation with serum apelin levels among PD patients.


METHODS
A total of 40 PD patients were enrolled into the study. Depressive symptoms and anxiety were assessed with the Beck's Depression Inventory and the Beck's Anxiety Inventory. Serum apelin-12 levels were measured by immunoenzymatic assays using commercially available ELISA kit for standard human apelin.


RESULTS
Of the patients, 16 (40%) had depression, 20 (50%) had anxiety. The patients with depression and anxiety had a significantly longer time on dialysis (p < 0.001 for both), significantly higher serum apelin (p < 0.001 for both) and C-reactive protein levels (p < 0.001 for both) than those without depression and anxiety. In multivariate analysis, serum apelin was the only parameter associated independently with depression and anxiety scores.


CONCLUSIONS
A substantial number of PD patients had depression and anxiety. Increased levels of serum apelin may constitute a significant independent predictor of development of depression and anxiety in PD patients.
a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey.
Ebru
E
Gok Oguz
a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey.
Hadim
H
Akoglu
a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey.
Gulay
G
Ulusal Okyay
a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey.
Ozlem
O
Yayar
a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey.
Guner
G
Karaveli Gursoy
a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey.
Mehmet
M
Buyukbakkal
a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey.
Basol
B
Canbakan
a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey.
Mehmet Deniz
MD
Ayli
D000328:Adult; D001007:Anxiety / Q000097:blood* / Q000209:etiology; D002097:C-Reactive Protein / Q000032:analysis; D003863:Depression / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D015995:Prevalence; D011569:Psychiatric Status Rating Scales
D036341:Intercellular Signaling Peptides and Proteins; C495200:apelin-12 peptide; D002097:C-Reactive Protein
Anxiety; C-reactive protein; apelin; depression; peritoneal dialysis