Arterial stiffness in patients with coronary artery disease: relation with in-stent restenosis following percutaneous coronary intervention.
Coronary artery disease (CAD) is one of the most important issues in modern medicine due to its high mortality and prevalence. An early detection and prevention can reduce morbidity and mortality. Arterial stiffness is a potent and independent predictor of CAD. We aimed to investigate the arterial stiffness in CAD patients undergoing the coronary angiography. Also, we investigated a possible correlation between arterial stiffness and in-stent restenosis (ISR), an important limitation of percutaneous coronary intervention (PCI).



The study included 160 patients undergoing coronary angiography, treated either with PCI or with CABG. The pulse wave velocity (PWV) and augmentation index (AIx) were measured by the Arteriograph.



PWV in the CAD group (12.24 ± 2.78 m/s) was significantly higher compared to the control group (8.27 ± 1.89 m/s). PWV in ISR and left main (LM) stenosis group (14.03 ± 3.15 and 13.89 ± 2.95 m/s) was significantly higher compared to the control and CAD groups. Peripheral and central AIx were significantly higher in CAD group (1.38 ± 30.63 % and 38.35 ± 15.52 %) than in control group (-11.35 ± 26.74 % and 26.91 ± 10.62 %). Patients with LM stenosis have significantly higher values of peripheral and central AIx (23.37 ± 23.77 % and 49.71 ± 12.02 %) than the CAD and ISR group.



The study confirmed a positive correlation between arterial stiffness measures, PWV and AIx, and CAD. Also, this study showed the correlation between PWV and ISR which can help to select more appropriate stent.
Department of Cardiology, University Hospital Mostar, Bijeli Brijeg bb, 88 000, Mostar, Bosnia and Herzegovina.
Zrinko
Z
Prskalo
Department of Cardiology, University Hospital Mostar, Bijeli Brijeg bb, 88 000, Mostar, Bosnia and Herzegovina. ibrizic@gmail.com.
Ivica
I
Brizić
Department of Cardiology, University Hospital Mostar, Bijeli Brijeg bb, 88 000, Mostar, Bosnia and Herzegovina.
Darko
D
Markota
Department of Cardiology, University Hospital Mostar, Bijeli Brijeg bb, 88 000, Mostar, Bosnia and Herzegovina.
Ivica
I
Markota
Department of Pharmacology, University of Split, Split, Croatia.
Mladen
M
Boban
Department of Nephrology, University Hospital Mostar, Mostar, Bosnia and Herzegovina.
Monika
M
Tomic
Department of Cardiology, University Hospital Dubrava, Zagreb, Croatia.
Boris
B
Starcevic
D001783:Blood Flow Velocity / Q000502:physiology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D011183:Postoperative Complications; D063177:Pulse Wave Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D015607:Stents / Q000009:adverse effects*; D059289:Vascular Stiffness / Q000502:physiology*
Coronary artery disease; Coronary restenosis; Vascular stiffness