Characterization of a novel HLA-B*40 allele, HLA-B*40:186:02, by cloning and sequencing.
A novel HLA-B*40 variant, HLA-B*40:186:02, has been identified by cloning and sequencing in a southern Chinese Han population. Aligned with HLA-B*40:01:01, HLA-B*40:186:02 has a nonsynonymous cytosine mutation at nucleotide position 165 in exon 2, leading to amino acid change from glycine to arginine at codon 56. It differs from HLA-B*40:186:01 by a synonymous change (adenine to cytosine) at position 165 in exon 2.
Immunogenetics Research Group, Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, China.
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Wang
HLA typing laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.|Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, China.
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Zhang
Immunogenetics Research Group, Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, China.
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Cai
HLA typing laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang, China.|Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou, China.
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Zhu
Immunogenetics Research Group, Department of Immunology, College of Basic Medical Sciences, Central South University, Changsha, China.
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Tian
D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics* / Q000276:immunology; D044466:Asian People; D001483:Base Sequence; D002681:China; D003001:Cloning, Molecular; D005091:Exons / Q000235:genetics / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans
D015235:HLA-B Antigens