miR-1207-3p Is a Novel Prognostic Biomarker of Prostate Cancer.
MicroRNAs (miRNAs) have been found to be dysregulated in prostate cancer (PCa). In this study, we investigated if miR-1207-3p is capable of distinguishing between indolent and aggressive PCa and if it contributes to explaining the disproportionate aggressiveness of PCa in men of African ancestry (moAA). A total of 404 patients with primary adenocarcinoma of the prostate were recruited between 1988 and 2003 at the Moffitt Cancer Center, Tampa, FL, USA. Patient clinicopathological features and demographic characteristics such as race were identified. RNA samples from 404 postprostatectomy prostate tumor tissue samples were analyzed by real-time quantitative reverse transcription polymerase chain reaction for the mRNA expression of miR-1207-3p. miR-1207-3p expression in PCa that resulted in overall death or PCa-specific death is significantly higher than in PCa cases that did not. The same positive correlation holds true for other clinical characteristics such as biochemical recurrence, Gleason score, clinical stage, and prostate-specific antigen level. Furthermore, miR-1207-3p expression was significantly less in moAA in comparison to Caucasian men. We also evaluated whether miR-1207-3p is associated with clinical outcomes adjusted for age at diagnosis and tumor stage in the modeling. Using competing risk regression, the PCa patients with a high miR-1207-3p expression (≥6 vs 3) had a high risk to develop PCa recurrence (hazard rate = 2.5, P < .001) adjusting for age at diagnosis and tumor stage. In conclusion, miR-1207-3p is a promising novel prognostic biomarker for PCa. Furthermore, miR-1207-3p may also be important in explaining the disproportionate aggressiveness of PCa in moAA.
Department of Biological Sciences, Hunter College of The City University of New York, New York, NY, 10065, USA; The Graduate Center Departments of Biology and Biochemistry, The City University of New York, New York, NY, 10016, USA.
Dibash K
DK
Das
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Joseph R
JR
Osborne
School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, 70112.
Hui-Yi
HY
Lin
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, 33612, USA. Electronic address: jong.park@moffitt.org.
Jong Y
JY
Park
Department of Biological Sciences, Hunter College of The City University of New York, New York, NY, 10065, USA; The Graduate Center Departments of Biology and Biochemistry, The City University of New York, New York, NY, 10016, USA; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College Cornell University, New York, NY, 10065, USA. Electronic address: ogunwobi@genectr.hunter.cuny.edu.
Olorunseun O
OO
Ogunwobi