Multiwalled Carbon Nanotubules Induce Pathological Changes in the Digestive Organs of Mice.
We studied the effects of regular long-term exposure to industrial nanomaterial based on multiwalled carbon nanotubules on the digestive system of mice. Nanomaterial in a concentration of 30 mg/kg was administered with drinking water over 30 days. Tissue specimens from the small intestine and liver were studied by light and electron microscopy. Multiwalled carbon nanotubules caused multiple necrotic foci in the small intestine and mixed parenchymatous degeneration in the liver. These findings suggested that multiwalled carbon nanotubules entering the digestive tract damaged intestinal villi, presumably via mechanical damage to enterocytes. It seems that multiwalled carbon nanotubules could cause degeneration indirectly, by triggering inflammatory reactions and ROS generation.
M. V. Lomonosov Moscow State University, Moscow, Russia. imber.acidis@gmail.com.
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Masyutin
M. V. Lomonosov Moscow State University, Moscow, Russia.
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Erokhina
M. V. Lomonosov Moscow State University, Moscow, Russia.
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Sychevskaya
Nanotechnologies and Nanomaterials Research and Education Center, G. R. Derzhavin Tambov State University, Tambov, Russia.
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Gusev
Nanotechnologies and Nanomaterials Research and Education Center, G. R. Derzhavin Tambov State University, Tambov, Russia.
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Vasyukova
NanoTechCenter, Tambov, Russia.
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Tkachev
M. V. Lomonosov Moscow State University, Moscow, Russia.
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Smirnova
M. V. Lomonosov Moscow State University, Moscow, Russia.
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Onishchenko
D000818:Animals; D048430:Cell Shape / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D020895:Enterocytes / Q000187:drug effects / Q000502:physiology; D022781:Hepatocytes / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology*; D007421:Intestine, Small / Q000187:drug effects / Q000473:pathology*; D007728:Kupffer Cells / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D037742:Nanotubes, Carbon / Q000633:toxicity*; D009336:Necrosis / Q000139:chemically induced
D037742:Nanotubes, Carbon
enterocyte necrosis; liver degeneration; multiwalled carbon nanotubules