Genetic Studies on Polycystic Ovary Syndrome.
Polycystic ovary syndrome (PCOS) is a highly heterogeneous reproductive system disorder of which the aetiology is not fully understood. Previous association studies have been conducted on >100 candidate genes, which principally related to reproductive hormones, cellular metabolism and chronic inflammation. Heritable tendencies have long been recognized for pathogeneses of PCOS, and recently a genome-wide association study (GWAS) in PCOS provides new clues to understand the genetic components and pathways in PCOS physiology. However, the current knowledge of the pathogenesis of PCOS is still in its infancy. Further studies using new technologies such as next-generation sequencing (NGS) shall be useful to understand more causal variants for PCOS.
Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China; The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.
Han
H
Zhao
Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China; The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.
Yue
Y
Lv
Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China; The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.
Lei
L
Li
Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China; The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China. Electronic address: chenzijiang@hotmail.com.
Zi-Jiang
ZJ
Chen
D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000235:genetics; D015703:Antigens, CD / Q000235:genetics; D044466:Asian People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics; D007328:Insulin / Q000235:genetics; D055504:Insulin Receptor Substrate Proteins / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D011972:Receptor, Insulin / Q000235:genetics; D011944:Receptors, Androgen / Q000235:genetics; D012738:Sex Hormone-Binding Globulin / Q000235:genetics; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D044465:White People / Q000235:genetics
D015703:Antigens, CD; C508600:IL6 protein, human; D007328:Insulin; D055504:Insulin Receptor Substrate Proteins; D015850:Interleukin-6; D011944:Receptors, Androgen; D012738:Sex Hormone-Binding Globulin; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human; C501892:CYP17A1 protein, human; D013254:Steroid 17-alpha-Hydroxylase; C435941:INSR protein, human; D011972:Receptor, Insulin
genetic association study; genome-wide association study; polycystic ovary syndrome