The His131Arg substitution in the FCGR2A gene (rs1801274) is not associated with the severity of influenza A(H1N1)pdm09 infection.
BACKGROUND
The virulence and pathogenicity of different influenza strains are responsible for a more or less severe disease. Recent studies have attempted to understand how host genetic factors may influence the clinical presentation of the disease. In the present study, the His131Arg (rs1801274) polymorphism was investigated in individuals from a Brazilian admixed population with a diagnosis of influenza A(H1N1)pdm09 infection.


METHODS
In the present study, the influence of the His131Arg (rs1801274) polymorphism, a variant of the FCGR2A gene, was investigated in 436 patients with a diagnosis of influenza A(H1N1)pdm09, evaluated at health services in the northern and northeastern regions of Brazil between June 2009 and August 2010. Patients were divided into a group of non-hospitalized patients (n = 192) and a group of hospitalized patients (n = 244; 100 of them died).


RESULTS
No significant difference in the allele or genotype frequencies of the rs1801274 polymorphism was observed between groups (p = 0.952 and p = 0.388). Multinomial logistic regression showed no effect of the rs1801274 polymorphism on severity or death of patients from the Brazilian admixed population (p = 0.368 and p = 0.469).


CONCLUSIONS
The rs1801274 polymorphism is not associated with severe disease in patients infected with influenza A(H1N1)pdm09.
Alvino Maestri Neto, Laboratório de Genética Humana e Médica, Universidade Federal do Pará, Cidade Universitária Prof. José da Silveira Neto, Rua Augusto Corrêa, 01, BOX 8615, CEP 66.075-970, Belém, Pará, Brazil. alvimaestri@hotmail.com.
Alvino
A
Maestri
Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, Pará, Brazil.
Vinicius Albuquerque
VA
Sortica
Laboratório de Vírus Respiratórios, Seção de Virologia Instituto Evandro Chagas, Ananindeua, Pará, Brazil.
Deimy Lima
DL
Ferreira
Laboratório de Vírus Respiratórios, Seção de Virologia Instituto Evandro Chagas, Ananindeua, Pará, Brazil.
Jessylene
J
de Almeida Ferreira
Laboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém, Pará, Brazil.
Marcos Antônio Trindade
MA
Amador
Laboratório de Vírus Respiratórios, Seção de Virologia Instituto Evandro Chagas, Ananindeua, Pará, Brazil.
Wyller Alencar
WA
de Mello
Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, Pará, Brazil.|Laboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém, Pará, Brazil.
Sidney Emanuel Batista
SE
Santos
Instituto Evandro Chagas, Universidade Federal do Pará, Belém, Pará, Brazil.
Rita Catarina Medeiros
RC
Sousa
D000293:Adolescent; D000328:Adult; D000483:Alleles; D019943:Amino Acid Substitution; D001120:Arginine / Q000235:genetics; D002648:Child; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006639:Histidine / Q000235:genetics; D054884:Host-Pathogen Interactions; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000254:growth & development* / Q000502:physiology; D007251:Influenza, Human / Q000235:genetics* / Q000473:pathology / Q000821:virology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017452:Receptors, IgG / Q000235:genetics*; D012720:Severity of Illness Index; D055815:Young Adult
C445323:FCGR2A protein, human; D017452:Receptors, IgG; D006639:Histidine; D001120:Arginine
A(H1N1)pdm09 infection; FCGR2A; Influenza