Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case Series.
Purpose. To evaluate daily spectral-domain optical coherence tomography (SD-OCT) changes in naive-treatment patients with diagnosis of exudative age-related macular degeneration (AMD) treated with intravitreous bevacizumab (1.25 mg), during a 30-day follow-up period. Methods. In prospective, interventional study, SD-OCT was performed daily for 30 days after the first intravitreal injection. The baseline, initial-decrease, minimal, and final central retinal thicknesses (CRTs) were assessed. Results. Nine eyes of nine patients with neovascular AMD were enrolled. The mean baseline CRT was 625.3 ± 182.5 μm, and the mean final CRT was 383.4 ± 163.0 μm (mean difference, 206.1 ± 167.6 μm), a difference that reached significance (P = 0.006). After the first injection, the initial decrease in the CRT was seen as an average of one day after injection (mean CRT, 503.6 ± 189.10 μm; P = 0.0431). The speed of the reduction in the CRT tended to decrease by day 17. The mean CRT was 336.5 ± 105.44 μm and the mean minimal CRT on day 30 was 320.75 ± 96.38 μm. Conclusion. The CRT decreased early after the first injection. We observed a tendency for reductions in the speed with which the CRT decreased by day 17 after the first injection, which may affect retreatment regime.
Department of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, Brazil.
Eduardo A
EA
Novais
Department of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, Brazil.
Emmerson
E
Badaró
Department of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, Brazil.
Flavio E
FE
Hirai
Department of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, Brazil.
Felipe Abdo
FA
Jorge
Department of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, Brazil.
Paula
P
Leal
Department of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, Brazil.
Michel Eid
ME
Farah
Department of Ophthalmology, Federal University of São Paulo, 04023-062 São Paulo, SP, Brazil.
Eduardo B
EB
Rodrigues