Role of Cardiac Myocytes Heart Fatty Acid Binding Protein Depletion (H-FABP) in Early Myocardial Infarction in Human Heart (Autopsy Study).
BACKGROUND
Many immunohistochemical markers have been used in the postmortem detection of early myocardial infarction.


OBJECTIVE
In the present study we examined the role of Heart-type fatty acid binding protein (H-FABP), in the detection of early myocardial infarction.


METHODS
We obtained samples from 40 human autopsy hearts with/without histopathological signs of ischemia.


RESULTS
All cases of definite and probable myocardial infarction showed a well-defined area of H-FABP depletion. All of the control cases showed strong H-FABP expression, except two markedly autolysed myocardial samples that showed affected antigenicity.


CONCLUSIONS
Thus, we suggest H-FABP as being one of the valuable tools facing the problem of postmortem detection of early myocardial infarction/ischemia, but not in autolysis.
Egyptian Forensic Medicine Authority, Pathology Department, Cairo, Egypt.
Amany
A
Shabaiek
Faculty of Medicine, Kasr El- Aini, Pathology Department, Cairo, Egypt.
Nour El-Hoda
Nel-H
Ismael
Faculty of Medicine, Kasr El- Aini, Pathology Department, Cairo, Egypt.
Samar
S
Elsheikh
Egyptian Forensic Medicine Authority, Pathology Department, Cairo, Egypt.
Hebat Allah
HA
Amin
H-FABP; MI; detection myocardial infarction; immunohistochemistry; sudden cardiac death