Single step synthesis, characterization and applications of curcumin functionalized iron oxide magnetic nanoparticles.
Magnetic iron oxide nanoparticles have been well known for their applications in magnetic resonance imaging (MRI), hyperthermia, targeted drug delivery, etc. The surface modification of these magnetic nanoparticles has been explored extensively to achieve functionalized materials with potential application in biomedical, environmental and catalysis field. Herein, we report a novel and versatile single step methodology for developing curcumin functionalized magnetic Fe3O4 nanoparticles without any additional linkers, using a simple coprecipitation technique. The magnetic nanoparticles (MNPs) were characterized using transmission electron microscopy, X-ray diffraction, fourier transform infrared spectroscopy and thermogravimetric analysis. The developed MNPs were employed in a cellular application for protection against an inflammatory agent, a polychlorinated biphenyl (PCB) molecule.
Chemical and Materials Engineering Department, University of Kentucky, Lexington, KY 40506.
Rohit
R
Bhandari
Chemical and Materials Engineering Department, University of Kentucky, Lexington, KY 40506.
Prachi
P
Gupta
Chemical and Materials Engineering Department, University of Kentucky, Lexington, KY 40506.
Thomas
T
Dziubla
Chemical and Materials Engineering Department, University of Kentucky, Lexington, KY 40506. Electronic address: zach.hilt@uky.edu.
J Zach
JZ
Hilt
D003474:Curcumin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D052203:Ferrosoferric Oxide / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D061307:Human Umbilical Vein Endothelial Cells / Q000378:metabolism*; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011078:Polychlorinated Biphenyls / Q000633:toxicity
D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D011078:Polychlorinated Biphenyls; D003474:Curcumin; D052203:Ferrosoferric Oxide
Anti-inflammatory; Cell viability; Curcumin; Functionalization; Iron oxide