Comparison of the cohesion-adhesion balance approach to colloidal probe atomic force microscopy and the measurement of Hansen partial solubility parameters by inverse gas chromatography for the prediction of dry powder inhalation performance.
The abilities of the cohesive-adhesive balance approach to atomic force microscopy (AFM) and the measurement of Hansen partial solubility parameters by inverse gas chromatography (IGC) to predict the performance of carrier-based dry powder inhaler (DPI) formulations were compared. Five model drugs (beclometasone dipropionate, budesonide, salbutamol sulphate, terbutaline sulphate and triamcinolone acetonide) and three model carriers (erythritol, α-lactose monohydrate and d-mannitol) were chosen, giving fifteen drug-carrier combinations. Comparison of the AFM and IGC interparticulate adhesion data suggested that they did not produce equivalent results. Comparison of the AFM data with the in vitro fine particle delivery of appropriate DPI formulations normalised to account for particle size differences revealed a previously observed pattern for the AFM measurements, with a slightly cohesive AFM CAB ratio being associated with the highest fine particle fraction. However, no consistent relationship between formulation performance and the IGC data was observed. The results as a whole highlight the complexity of the many interacting variables that can affect the behaviour of DPIs and suggest that the prediction of their performance from a single measurement is unlikely to be successful in every case.
Department of Pharmaceutics, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, United Kingdom; Department of Pharmacy and Pharmacology, University of Bath, Bath, BA2 7AY, United Kingdom. Electronic address: M.D.Jones@bath.ac.uk.
Matthew D
MD
Jones
Department of Pharmaceutics, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, United Kingdom. Electronic address: g.buckton@ucl.ac.uk.
Graham
G
Buckton
D000268:Adhesiveness; D000280:Administration, Inhalation; D000420:Albuterol / Q000737:chemistry; D001507:Beclomethasone / Q000737:chemistry; D019819:Budesonide / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002849:Chromatography, Gas / Q000379:methods; D003102:Colloids / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D058995:Dry Powder Inhalers / Q000379:methods; D004896:Erythritol / Q000737:chemistry; D007785:Lactose / Q000737:chemistry; D008353:Mannitol / Q000737:chemistry; D018625:Microscopy, Atomic Force / Q000379:methods; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011208:Powders / Q000737:chemistry*; D012995:Solubility; D013726:Terbutaline / Q000737:chemistry; D014222:Triamcinolone Acetonide / Q000737:chemistry
D003102:Colloids; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011208:Powders; D008353:Mannitol; D019819:Budesonide; D014222:Triamcinolone Acetonide; D007785:Lactose; D001507:Beclomethasone; D013726:Terbutaline; D000420:Albuterol; D004896:Erythritol
Adhesion; Atomic force microscopy; Dry powder inhaler (DPI); Inverse gas chromatography; Materials science; Physical characterisation