Sjögren's Syndrome and Silicosis - a Case Report.
Sjögren's syndrome is an autoimmune disease of unknown etiology where immune response to self-antigens is believed to result from interactions between genetic and environmental factors. We describe the case of a patient who has been diagnosed with Sjögren's syndrome based on typical clinical and immunological parameters. The clinical picture was dominated by the respiratory symptoms, and radiographic and multislice computed tomography examination of the chest showed certain changes characteristic of pneumoconiosis. Given that the patient has worked in a foundry where he has been exposed to the silica dust, he was subject to examination by occupational health specialists under the suspicion of lung silicosis, who confirmed the silicosis. This case report points to the possible connection between a professional exposure to silica and Sjögren's syndrome. Occupational exposure to silica is a possible risk factor for the development of autoimmune diseases, and in the evaluation of patients with connective tissue diseases it is important to consider work-related history.
Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade, Serbia.
Aleksandra
A
Plavsic
Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade, Serbia.
Rada
R
Miskovic
Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade, Serbia.
Jasna
J
Bolpacic
Serbian Institute for Occupational Health "Dr Dragomir Karajović", Belgrade, Serbia.
Branka
B
Šuštran
Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade, Serbia.
Aleksandra
A
Peric-Popadic
Clinical Center of Serbia, Clinic for Allergology and Immunology, Belgrade, Serbia.
Mirjana
M
Bogic
Sjögren’s syndrome; autoimmune diseases; environmental factor; silica; silicosis