Fat grafting for breast cancer patients: From basic science to clinical studies.
Fat grafting in the surgical treatment of breast cancer has become popular in a short period of time because of the rising expectations of good esthetic results by the patients as well as the simplicity of the technique; however, the oncological safety for breast cancer patients remains a matter of debate. The procedure raises many questions considering that recent in-vitro studies have shown that fat grafting could promote tumor recurrence through diverse mechanisms, or even facilitate distant metastasis. We present a review of the currently available experimental and clinical data in order to describe and discuss patient selection criteria following breast cancer surgery.
Department of Surgery, AuslRomagna, Ravenna, Italy. Electronic address: RGennariMD@gmail.com.
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Gennari
Medical Oncology 2, Venetian Oncological Institute, Padova, Italy; Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy.
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Griguolo
Medical Oncology 2, Venetian Oncological Institute, Padova, Italy; Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy.
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Dieci
Medical Oncology 2, Venetian Oncological Institute, Padova, Italy; Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy.
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Guarneri
Department of Emergency, Plastic and Reconstructive Surgery, AuslRomagna, Cesena, Italy.
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Tavaniello
Department of Surgery, AuslRomagna, Ravenna, Italy.
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Sibilio
Medical Oncology 2, Venetian Oncological Institute, Padova, Italy; Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy.
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Conte
D000273:Adipose Tissue / Q000637:transplantation*; D000818:Animals; D001943:Breast Neoplasms / Q000601:surgery*; D002277:Carcinoma / Q000601:surgery*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D016462:Mammaplasty / Q000379:methods*; D015412:Mastectomy, Segmental / Q000379:methods*; D051379:Mice; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D018579:Patient Selection; D014182:Transplantation, Autologous; D059016:Tumor Microenvironment
ASCs (adipose stem cells); Breast cancer; Fat grafting; Lipoffiling; Oncological outcome; Safety