Richter's transformation presenting as splenic rupture after 6 years of complete remission of chronic lymphocytic leukaemia.
Richter's transformation is a rare clinical condition occurring in about 5-10% of patients with chronic lymphocytic leukaemia (CLL). Patients usually present with lymphadenopathy, hepatosplenomegaly and elevated serum lactate dehydrogenase levels. These patients have a very poor prognosis with a median survival of about 10 months. We present a patient, with a history of CLL in complete remission, who presented with splenic rupture requiring splenectomy. She was eventually diagnosed with diffuse large B-cell lymphoma with Richter's transformation.
Department of Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.
Braghadheeswar
B
Thyagarajan
Department of Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.
Sayee Sundar
SS
Alagusundaramoorthy
Department of Pathology, Monmouth Medical Center, Long Branch, New Jersey, USA.
Lopa
L
Shah
Department of Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.
Abhinav
http://orcid.org/0000-0003-1080-6449
A
Agrawal
D000368:Aged; D002471:Cell Transformation, Neoplastic; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000473:pathology; D011379:Prognosis; D013156:Splenectomy; D013161:Splenic Rupture / Q000209:etiology / Q000601:surgery*