Two Unusual Cases of Human Immunodeficiency Virus-Negative Patients with Talaromyces marneffei Infection.
Talaromyces marneffei (formerly known as Penicillium marneffei) is a dimorphic fungus endemic in south and southeast Asia. It is not only commonly found in human immunodeficiency virus (HIV)-infected patients, but also among HIV-negative immunocompromised patients. The infection caused by this pathogen can disseminate hematogenously to other locations. Herein, we report for the first time two cases complicated with a rare disease or involving a rare site: in the first case, T. marneffei infection was complicated by Langerhans cell histiocytosis, whereas the second case showed clear etiological evidence of pleural nodules and pleural effusion caused by T. marneffei and diagnosed by thoracoscopic pleural biopsy.
Department of Comprehensive Internal Medicine, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
Ye
Y
Qiu
Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Mingqi
M
Pan
Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. jqzhang2002@sina.com.
Jianquan
J
Zhang
Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xiaoning
X
Zhong
Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yu
Y
Li
Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Hui
H
Zhang
Department of Comprehensive Internal Medicine, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
Bixun
B
Li
D005260:Female; D006678:HIV; D006646:Histiocytosis, Langerhans-Cell / Q000000981:diagnostic imaging / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000000981:diagnostic imaging / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D009894:Opportunistic Infections / Q000000981:diagnostic imaging / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D010996:Pleural Effusion / Q000000981:diagnostic imaging / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D049268:Positron-Emission Tomography; D032901:Talaromyces / Q000254:growth & development / Q000302:isolation & purification* / Q000472:pathogenicity; D013906:Thoracoscopy