Can symptoms help in differential diagnosis between substance-induced vs independent psychosis in adults with a lifetime diagnosis of cocaine use disorder?
The main goal of this study it is explore the psychopathological differences between IPD and SIPD in a sample of 125 adults with a lifetime diagnosis of cocaine disorder recruited from treatment setting and through street contacts. A secondary analysis of six cross-sectional studies was conducted between 2000 and 2010. SIPD and IPD were diagnosed using the Psychiatric Research Interview for Substance and Mental Disorders (PRISM). 38 subjects (30.4%) were diagnosed with lifetime IPD and 87 (69.6%) with lifetime SIPD. A binomial logistic regression analysis using SIPD as the reference group showed that only previous prison admissions (OR 2.59; 95% CI 1.05, 6.36) and visual hallucinations (OR 5.21; 95% CI 1.54, 17.65) remained significant variables in the group with lifetime SIPD. In the group with lifetime IPD, grandiose delusions (OR 0.19; 95% CI 0.06, 0.60) and disorganized speech (OR 0.16; 95% CI 0.04, 0.61) remained significant. Model predicts the diagnosis of lifetime SIPD with a sensitivity of 80.3% and a specificity of 78.2%. This clinical profile of lifetime SIPD could help distinguish between IPD and SIPD among adults with lifetime diagnosis of cocaine disorder.
Department of Education and Psychobiology, Universidad Internacional de la Rioja (UNIR). Gran Vía Rey Juan Carlos I, 41, 26002 Logroño, La Rioja, Spain; Red de Trastornos Adictivos, Grupo de Investigación en Neurociencias Traslacional en Adicciones (GRINTA), Universidad de Granada, Spain.
Esperanza
E
Vergara-Moragues
Institut Hospital del Mar d'Investigacions Mèdiques, Parc de Salut Mar, Passeig Maritim, 25-29, 08003, Barcelona, Spain; Institut de Neuropsiquiatria i Addictions, Parc de Salut Mar, Universitat Autònoma de Barcelona, Passeig Maritim, 25-29, 08003, Barcelona, Spain.
Joan I
JI
Mestre-Pintó
FIMABIS, Mental Health Clinical Management Unit, Hospital Carlos Haya, Avda Carlos Haya 82, Pabellón de Gobierno Sótano, 29010 Málaga, Spain.
Pedro Araos
PA
Gómez
FIMABIS, Mental Health Clinical Management Unit, Hospital Carlos Haya, Avda Carlos Haya 82, Pabellón de Gobierno Sótano, 29010 Málaga, Spain.
Fernando
F
Rodríguez-Fonseca
Institut Hospital del Mar d'Investigacions Mèdiques, Parc de Salut Mar, Passeig Maritim, 25-29, 08003, Barcelona, Spain; Institut de Neuropsiquiatria i Addictions, Parc de Salut Mar, Universitat Autònoma de Barcelona, Passeig Maritim, 25-29, 08003, Barcelona, Spain.
Marta
M
Torrens
Red de Trastornos Adictivos, Grupo de Investigación en Neurociencias Traslacional en Adicciones (GRINTA), Universidad de Granada, Spain; Community Mental Health Unit of Villamartin, Jerez Hospital, Andalusian Health Service, Avda Feria 58 Villamartin, 11650 Cádiz, Spain. Electronic address: pacogonzalez62@hotmail.com.
Francisco
F
González-Saiz
D000328:Adult; D019970:Cocaine-Related Disorders / Q000523:psychology*; D003430:Cross-Sectional Studies; D003702:Delusions / Q000175:diagnosis / Q000523:psychology; D003937:Diagnosis, Differential; D005260:Female; D006212:Hallucinations / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D008297:Male; D011379:Prognosis; D011605:Psychoses, Substance-Induced / Q000175:diagnosis* / Q000523:psychology; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000523:psychology; D013030:Spain
Cocaine; Psychosis; Schizophrenia; Substance use; Substance-induced