Diterpenoid alkaloids from the roots of Aconitum brachypodum Diels.
A new diterpenoid alkaloid, named bullatine H (1), along with 10 known diterpenoid alkaloids were isolated from the roots of Aconitum brachypodum Diels (Ranunculaceae). The structure of 1 was elucidated by analysis of its spectroscopic data. It should be noted that compound 1 is the first example with 11, 13-dioxygenated denudatine-type diterpenoid alkaloid isolated from Aconitum brachypodum.
a Yunnan Institute of Materia Medica , Kunming 650111 , China.|b Yunnan Bai Yao Group Innovation and R&D Center , Kunming 650111 , China.|c Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation , Kunming 650111 , China.
Li-Guo
LG
Yang
a Yunnan Institute of Materia Medica , Kunming 650111 , China.|b Yunnan Bai Yao Group Innovation and R&D Center , Kunming 650111 , China.|c Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation , Kunming 650111 , China.
Ying-Jie
YJ
Zhang
a Yunnan Institute of Materia Medica , Kunming 650111 , China.|b Yunnan Bai Yao Group Innovation and R&D Center , Kunming 650111 , China.|c Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation , Kunming 650111 , China.
Jia-Ying
JY
Xie
a Yunnan Institute of Materia Medica , Kunming 650111 , China.|b Yunnan Bai Yao Group Innovation and R&D Center , Kunming 650111 , China.|c Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation , Kunming 650111 , China.
Wei-Jun
WJ
Xia
a Yunnan Institute of Materia Medica , Kunming 650111 , China.|b Yunnan Bai Yao Group Innovation and R&D Center , Kunming 650111 , China.|c Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation , Kunming 650111 , China.
Hai-Yuan
HY
Zhang
a Yunnan Institute of Materia Medica , Kunming 650111 , China.|b Yunnan Bai Yao Group Innovation and R&D Center , Kunming 650111 , China.|c Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation , Kunming 650111 , China.
Meng-Yun
MY
Tang
a Yunnan Institute of Materia Medica , Kunming 650111 , China.|b Yunnan Bai Yao Group Innovation and R&D Center , Kunming 650111 , China.|c Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation , Kunming 650111 , China.
Shuang-Xi
SX
Mei
a Yunnan Institute of Materia Medica , Kunming 650111 , China.|b Yunnan Bai Yao Group Innovation and R&D Center , Kunming 650111 , China.|c Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation , Kunming 650111 , China.
Tao
T
Cui
a Yunnan Institute of Materia Medica , Kunming 650111 , China.|b Yunnan Bai Yao Group Innovation and R&D Center , Kunming 650111 , China.|c Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation , Kunming 650111 , China.
Jing-Kun
JK
Wang
a Yunnan Institute of Materia Medica , Kunming 650111 , China.|b Yunnan Bai Yao Group Innovation and R&D Center , Kunming 650111 , China.|c Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation , Kunming 650111 , China.
Zhao-Yun
ZY
Zhu
D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry*
D000470:Alkaloids; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C000613871:bullatine H; C034767:denudatine
Aconitum brachypodum; Ranunculaceae; diterpenoid alkaloids; isolation; structure elucidation