Effectiveness of the South African expanded program of immunization against hepatitis B in children infected with human immunodeficiency virus-1 living in a resource-limited setting of Kwazulu-Natal.
Prevalence of Human-Immunodeficiency-Virus/Hepatitis-B-virus (HIV/HBV) coinfection and HBV vaccination response in children are unknown in Kwazulu-Natal. This study included 183 HIV-infected and 108 HIV-uninfected children aged between 5 and 15 years screened for HBV infection and vaccination. HBV infection occurred in 2.1% and 0% of HIV-infected and uninfected children respectively. Serological response to immunization was shown in 15.8% and 61.1% of HIV-infected and uninfected children, respectively (P < 0.001). Even if prevalence of HBV infection was low in these cohorts, HIV-infected children will stay at risk of infection if the vaccine schedule is not adapted. J. Med. Virol. 89:182-185, 2017. © 2016 Wiley Periodicals, Inc.
AIDS Reference Laboratory, Saint-Luc University Hospital, Catholic University of Louvain, Brussels, Belgium. medjis@hotmail.com.
Jean-Christophe
JC
Beghin
AIDS Reference Laboratory, Catholic University of Louvain, Brussels, Belgium.
Jean
J
Ruelle
Paediatric Hepatic and Gastro-Enterologic Diseases, Saint-Luc University Hospital, Catholic University of Louvain, Brussel, Belgium.
Etienne
E
Sokal
Great Hospital of Charleroi-Notre Dame, Charleroi, Belgium.
Antoine
A
Bachy
Edendale Regional Hospital, Edendale, South Africa.
Malini
M
Krishna
Edendale Regional Hospital, Edendale, South Africa.
Leslie
L
Hall
AIDS Reference Laboratory, Saint-Luc University Hospital, Catholic University of Louvain, Brussels, Belgium.
Patrick
P
Goubau
Paediatric Infectious Diseases, General Paediatrics, Saint-Luc University Hospital, Catholic University of Louvain, Brussels, Belgium.
Dimitri
D
Van der Linden
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D060085:Coinfection / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D006509:Hepatitis B / Q000453:epidemiology / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013019:South Africa / Q000453:epidemiology; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
D017325:Hepatitis B Vaccines
HIV/HBV co-infection; chronic hepatitis B; long-term outcome; resource-limited setting