Preparation of TiO2 nanotubes/mesoporous calcium silicate composites with controllable drug release.
Nanotube structures such as TiO2 nanotube (TNT) arrays produced by self-ordering electrochemical anodization have been extensively explored for drug delivery applications. In this study, we presented a new implantable drug delivery system that combined mesoporous calcium silicate coating with nanotube structures to achieve a controllable drug release of water soluble and antiphlogistic drug loxoprofen sodium. The results showed that the TiO2 nanotubes/mesoporous calcium silicate composites were successfully fabricated by a simple template method and the deposition of mesoporous calcium silicate increased with the soaking time. Moreover, the rate of deposition of biological mesoporous calcium silicate on amorphous TNTs was better than that on anatase TNTs. Further, zinc-incorporated mesoporous calcium silicate coating, produced by adding a certain concentration of zinc nitrate into the soaking system, displayed improved chemical stability. A significant improvement in the drug release characteristics with reduced burst release and sustained release was demonstrated.
College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou, Fujian 350007, China.
Chunling
C
Xie
College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou, Fujian 350007, China.
Ping
P
Li
College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou, Fujian 350007, China.
Yan
Y
Liu
College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou, Fujian 350007, China.
Fei
F
Luo
College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou, Fujian 350007, China. Electronic address: xfxiao@fjnu.edu.cn.
Xiufeng
X
Xiao
D017610:Calcium Compounds / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D053761:Nanocomposites / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*; D010666:Phenylpropionates / Q000737:chemistry* / Q000493:pharmacokinetics*; D017640:Silicates / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
D017610:Calcium Compounds; D003692:Delayed-Action Preparations; D010666:Phenylpropionates; D017640:Silicates; C009495:titanium dioxide; C040656:loxoprofen; D014025:Titanium; C031293:calcium silicate
Drug delivery; Loxoprofen sodium; Mesoporous calcium silicate; TiO(2) nanotube; Zinc