Depth of Hepatic Infiltration and Lymph Node Swelling as Factors for Considering Surgery for T2-4 Gallbladder Carcinoma Patients.
OBJECTIVE
The aim of the present study was to clarify if the degree of hepatic infiltration and lymph node swelling of gallbladder carcinoma (GBC) should be held as deciding factors for T2-4 GBC patients to undergo surgery.


METHODS
Fifty consecutive patients with T2-4 GBC who underwent surgery were reviewed retrospectively. We investigated the preoperative information and imaging factors as predictors of survival.


RESULTS
The estimated overall survival in all patients was lower in patients with hepatic infiltration ≥5 mm (n=12) than in those with <5 mm (n=38) (p=0.003). Multivariate analyses demonstrated that liver infiltration ≥5 mm (OR=2.251; 95%CI=0.906-5.596, p=0.081) and lymph node swelling (OR=2.462; 95%CI=1.034-5.859, p=0.042) were risk factors of poor survival.


CONCLUSIONS
Our results suggested that ≥5 mm liver infiltration and lymph node swelling may serve as deciding factors for surgery consideration in GBC patients.
Second Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Ken-Ichi
K
Okada
Second Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Manabu
M
Kawai
Second Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Masaki
M
Ueno
Second Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Seiko
S
Hirono
Second Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Motoki
M
Miyazawa
Second Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Shinya
S
Hayami
Second Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Atsushi
A
Shimizu
Second Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Yoshinobu
Y
Shigekawa
Second Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Yuji
Y
Kitahata
Second Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Atsushi
A
Miyamoto
Second Department of Surgery, Wakayama Medical University, Wakayama, Japan yamaue-h@wakayama-med.ac.jp.
Hiroki
H
Yamaue
D000328:Adult; D000368:Aged; D005260:Female; D005706:Gallbladder Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011183:Postoperative Complications / Q000209:etiology; D012189:Retrospective Studies
Gallbladder carcinoma; hepatic infiltration; lymph node metastasis