Senescence Can Be BETter without the SASP?
Global remodeling of the chromatin landscape occurs during senescence, although its functional consequence is still unclear. In this issue, Tasdemir and colleagues show that the epigenetic regulator BRD4 is required for expression of the proinflammatory senescence-associated secretory phenotype and immune clearance of senescent cells in vitro and in vivo Their results could be useful in the design of novel therapies to treat aging-related diseases, including cancer.Cancer Discov; 6(6); 576-8. ©2016 AACR.See related article by Tasdemir et al., p. 612.
Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom. Institute of Cancer Sciences College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Maria Grazia
MG
Vizioli
Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom. Institute of Cancer Sciences College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. p.adams@beaston.gla.ac.uk.
Peter D
PD
Adams
D016922:Cellular Senescence / Q000235:genetics*; D002843:Chromatin; D006801:Humans; D010641:Phenotype
D002843:Chromatin