Inflammasomes: Intracellular detection of extracellular bacteria.
The non-canonical inflammasome triggers host cell death and inflammation upon recognition of cytosolic LPS. A recent report in Cell now shows that Outer Membrane Vesicles (OMVs) of extracellular Gram-negative bacteria can deliver LPS into the host cell cytosol.
Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland.
Petr
P
Broz
D020169:Caspases; D003600:Cytosol; D006090:Gram-Negative Bacteria; D058847:Inflammasomes; D008070:Lipopolysaccharides
D058847:Inflammasomes; D008070:Lipopolysaccharides; D020169:Caspases