Dairy fat blend improves brain DHA and neuroplasticity and regulates corticosterone in mice.
Mimicking the breast milk lipid composition appears to be necessary for infant formula to cover the brain's needs in n-3 PUFA. In this study, we evaluated the impact of partial replacement of vegetable oil (VL) in infant formula by dairy fat (DL) on docosahexaenoic acid (DHA) brain level, neuroplasticity and corticosterone in mice. Mice were fed with balanced VL or balanced DL diets enriched or not in DHA and arachidonic acid (ARA) from the first day of gestation. Brain DHA level, microglia number, neurogenesis, corticosterone and glucocorticoid receptor expression were measured in the offsprings. DL diet increased DHA and neuroplasticity in the brain of mice at postnatal day (PND) 14 and at adulthood compared to VL. At PND14, ARA and DHA supplementation increased DHA in VL but not in DL mice brain. Importantly, DHA and ARA supplementation further improved neurogenesis and decreased corticosterone level in DL mice at adulthood. In conclusion, dairy lipids improve brain DHA level and neuroplasticity.
Nutrition et Neurobiologie Intégrée, INRA UMR 1286, 33076 Bordeaux, France; University of Bordeaux, Bordeaux, France.
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Dinel
Nutrition et Neurobiologie Intégrée, INRA UMR 1286, 33076 Bordeaux, France; University of Bordeaux, Bordeaux, France; ITERG, Institut des Corps Gras, 33600 Pessac, France.
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Rey
Lactalis Nutrition Europe, Torce F-35370, France.
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Bonhomme
Lactalis, R&D, Retiers F-35240, France.
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Le Ruyet
Nutrition et Neurobiologie Intégrée, INRA UMR 1286, 33076 Bordeaux, France; University of Bordeaux, Bordeaux, France.
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Joffre
Nutrition et Neurobiologie Intégrée, INRA UMR 1286, 33076 Bordeaux, France; University of Bordeaux, Bordeaux, France.
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Layé
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D003345:Corticosterone / Q000378:metabolism*; D003611:Dairy Products; D004041:Dietary Fats / Q000008:administration & dosage* / Q000494:pharmacology; D004281:Docosahexaenoic Acids / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000737:chemistry; D051379:Mice; D023421:Models, Animal; D009473:Neuronal Plasticity / Q000187:drug effects; D010938:Plant Oils / Q000008:administration & dosage* / Q000494:pharmacology; D011965:Receptors, Glucocorticoid / Q000187:drug effects
D004041:Dietary Fats; D010938:Plant Oils; D011965:Receptors, Glucocorticoid; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D003345:Corticosterone
DHA; Dairy lipid; HPA axis; Microglia; Neurogenesis; PUFA