3D genomics imposes evolution of the domain model of eukaryotic genome organization.
The hypothesis that the genome is composed of a patchwork of structural and functional domains (units) that may be either active or repressed was proposed almost 30 years ago. Here, we examine the evolution of the domain model of eukaryotic genome organization in view of the expansion of genome-scale techniques in the twenty-first century that have provided us with a wealth of information on genome organization, folding, and functioning.
Institute of Gene Biology RAS, Moscow, Russia.|LIA1066 "French-Russian Cancer Research Laboratory", Villejuif, France.|Lomonosov Moscow State University, Moscow, Russia.
Sergey V
SV
Razin
LIA1066 "French-Russian Cancer Research Laboratory", Villejuif, France. vassetzky@igr.fr.|Lomonosov Moscow State University, Moscow, Russia. vassetzky@igr.fr.|CNRS UMR8126, Université Paris Sud Paris Saclay, Institut Gustave Roussy, 39, rue Camille-Desmoulins, Villejuif, 94805, France. vassetzky@igr.fr.
Yegor S
YS
Vassetzky
D000818:Animals; D002843:Chromatin / Q000737:chemistry / Q000235:genetics; D044127:Epigenesis, Genetic; D057890:Epigenomics / Q000379:methods; D056890:Eukaryota / Q000235:genetics*; D016678:Genome; D023281:Genomics / Q000379:methods; D006801:Humans; D013329:Structure-Activity Relationship
D002843:Chromatin
Chromatin; Domains; Epigenetics; Large-scale organization