Relationship Between Obesity, Hypertension, and Aldosterone Production in Postmenopausal African American Women: A Pilot Study.
Increased abdominal obesity is associated with increased cardiovascular risk, especially in African American women. The adipocyte is documented to produce a number of inflammatory factors including the hormone aldosterone. There are very few data documenting aldosterone production from adipocytes of postmenopausal women as well as data demonstrating the effects of angiotensin receptor blockade (ARB) on its production in predominately African American women. The authors hypothesize that increased central adipocyte mass in obese postmenopausal women contributes to increased production of aldosterone that is suppressed with the ARB azilsartan medoxomil. The authors tested this hypothesis in a double-blind, placebo-controlled pilot study of 34 hypertensive postmenopausal women (mean age 57.5±7.5 years), 91% of whom were African American. Patients had a mean 24-hour ambulatory systolic blood pressure of 127±13 mm Hg off any blocker of the renin-angiotensin system but while taking other antihypertensive medications. The authors further validated aldosterone production in a nested cohort of women using fat cells from a fat pad biopsy. Azilsartan reduced 24-hour urinary aldosterone by 47.3% from baseline (P=.03), with between-groups differences in urine aldosterone of -5.3±52.3% placebo vs -47.3±32.9% azilsartan (P=.07) at 6 months. An adrenal cell line treated with adipocyte-conditioned media from subcutaneous abdominal adipocytes of postmenopausal women (n=3) showed an increase in aldosterone production blocked by an ARB (1948±1297 pg/mL fat alone vs 894±438 pg/mL fat + ARB; P=.022). The authors conclude that aldosterone is produced from subcutaneous adipocytes of obese postmenopausal women. Moreover, use of an ARB significantly reduces aldosterone production within 6 months of use in these women as well as in cells exposed to their adipocytes.
Department of Medicine, ASH Comprehensive Hypertension Center, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago Medicine, Chicago, IL, USA.
Luke J
LJ
Laffin
Department of Medicine, ASH Comprehensive Hypertension Center, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago Medicine, Chicago, IL, USA.
Colleen
C
Majewski
Department of Public Health Studies, The University of Chicago Biological Sciences, Chicago, IL, USA.
Chuanhong
C
Liao
Department of Medicine, ASH Comprehensive Hypertension Center, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago Medicine, Chicago, IL, USA.
George L
GL
Bakris
D017667:Adipocytes / Q000166:cytology / Q000378:metabolism; D001741:Black or African American; D000368:Aged; D000450:Aldosterone / Q000652:urine*; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000494:pharmacology; D002460:Cell Line; D017077:Culture Media, Conditioned / Q000494:pharmacology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000208:ethnology / Q000378:metabolism; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000208:ethnology / Q000378:metabolism*; D010069:Oxadiazoles / Q000008:administration & dosage* / Q000494:pharmacology; D010865:Pilot Projects; D017698:Postmenopause / Q000652:urine
D001562:Benzimidazoles; D017077:Culture Media, Conditioned; D010069:Oxadiazoles; D000450:Aldosterone; C557413:azilsartan medoxomil