Synthesis of (+)-Turmeronol A, an Inhibitor of Soybean Lipoxygenase, and (+)-ar-Turmerone.
Syntheses of optically pure turmeronol A and turmerone were achieved in a simple manner starting from ethyl (R)-3-hydroxybutanoate (4) of 100% e.e. The key step was the displacement of the chiral tosylate (6) with an organocopper reagent.
a Department of Agricultural Chemistry, The University of Tokyo , 1-1-1 Yayoi, Bunkyo-ku , Tokyo 113 , Japan.
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Kitahara
a Department of Agricultural Chemistry, The University of Tokyo , 1-1-1 Yayoi, Bunkyo-ku , Tokyo 113 , Japan.
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Furusho
a Department of Agricultural Chemistry, The University of Tokyo , 1-1-1 Yayoi, Bunkyo-ku , Tokyo 113 , Japan.
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Mori