Competing interests in a lung cancer with metastasis to the pituitary gland: syndrome of inappropriate ADH secretion versus diabetes insipidus.
Metastases to the pituitary gland are rare; cancers that most commonly metastasize to the pituitary are breast and lung cancers. No specific computed tomography or magnetic resonance imaging features reliably distinguish primary pituitary masses from metastases. A combination of a detailed clinical assessment together with specialist endocrine and neuroradiology support is essential to make the rare diagnosis of a pituitary metastasis. We present the case of a man with metastatic lung cancer, initially presenting as hypopituitarism. Subtle features in the history, together with neuroimaging findings atypical for pituitary adenomas, provided clues that the diagnosis was one of the pituitary metastases. Treatment of diabetes insipidus (DI) with replacement antidiuretic hormone (ADH) was complicated by extreme difficulties in achieving a satisfactory sodium and water balance. This was the result of coexistent DI and syndrome of inappropriate ADH secretion perpetuated by the patient's primary lung cancer, a phenomenon not previously described in the literature.
Department of Cardiovascular Sciences , University Hospitals of Leicester NHS Trust, Glenfield General Hospital , Leicester , UK.
Gaurav Singh
GS
Gulsin
Nottingham University Hospitals NHS Trust, Queen's Medical Centre , Nottingham, Nottinghamshire , UK.
Madeleine Louisa Bryson
ML
Jacobs
Department of Endocrinology , University Hospitals of Leicester NHS Trust , Leicester , UK.
Shailesh
S
Gohil
Department of Radiology , University Hospitals of Leicester NHS Trust , Leicester , UK.
Adam
A
Thomas
Department of Endocrinology , University Hospitals of Leicester NHS Trust , Leicester , UK.
Miles
M
Levy