Propofol Use in Pediatric Patients With Food Allergy and Eosinophilic Esophagitis.
Propofol is a safe, well-tolerated anesthetic that is labeled as contraindicated in patients with egg or soy allergy. This contraindication has become increasingly problematic given the rising incidence of food allergy and eosinophilic esophagitis (EoE). To address this issue, we studied practice patterns of propofol use for esophagogastroduodenoscopies in children with EoE and food allergies at our institution. A retrospective observational study of 1365 esophagogastroduodenoscopies from January 2013 to June 2014 was performed. Data were analyzed using Student t tests, chi square tests, Fisher exact tests, and multivariable logistic regression. We found that propofol was used significantly less in patients with egg or soy allergy, and in patients with EoE, even after adjusting for the presence of food allergy. There was no difference in complication rates relative to propofol use. Propofol was used safely in pediatric patients with EoE and food allergy in this limited single-center review.
*Digestive Health Institute †Gastrointestinal Eosinophilic Diseases Program, Digestive Health Institute ‡Department of Biostatistics §Gastrointestinal Eosinophilic Diseases Program, Section of Allergy and Immunology ¶Department of Anesthesiology, Children's Hospital Colorado, University of Colorado, School of Medicine, Aurora, CO.
Pooja
P
Mehta
Shikha S
SS
Sundaram
Glenn T
GT
Furuta
Zhaoxing
Z
Pan
Dan
D
Atkins
Scott
S
Markowitz
D000293:Adolescent; D018686:Anesthetics, Intravenous / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D003120:Colorado; D000075203:Contraindications, Drug; D016145:Endoscopy, Digestive System; D057765:Eosinophilic Esophagitis / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D015742:Propofol / Q000009:adverse effects; D012189:Retrospective Studies
D018686:Anesthetics, Intravenous; D015742:Propofol