Effect of Tannins in Green Tea on the Urinary Methylguanidine Excretion in Rats Indicating a Possible Radical Scavenging Action.
The hydroxyl radical scavenging action of green tea tannin given orally to rats with experimental renal failure was examined by using the urinary methylguanidine excretion as an index. In rats given 2 mg of a green tea tannin mixture, the urinary methylguanidine excretion was significantly decreased or had a tendency to decrease. (-)-Epigallocatechin 3-O-gallate, the predominant component of the green tea tannin mixture, effected a decrease in the urinary methylguanidine excretion in rats at a dose as low as 0.25 mg, suggesting a hydroxyl radical scavenging action.
a Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University , Sugitani, Toyama 930-01 , Japan.
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Yokozawa
a Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University , Sugitani, Toyama 930-01 , Japan.
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Oura
a Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University , Sugitani, Toyama 930-01 , Japan.|b Central Research Laboratories, Taiyo Kagaku Co., Ltd ., Yokkaichi, Mie 510 , Japan.
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Sakanaka
a Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University , Sugitani, Toyama 930-01 , Japan.|b Central Research Laboratories, Taiyo Kagaku Co., Ltd ., Yokkaichi, Mie 510 , Japan.
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Kim