From BPA to its analogues: Is it a safe journey?
Bisphenol-A (BPA) is one of the most abundant synthetic chemicals in the world due to its uses in plastics. Its widespread exposure vis-a-vis low dose effects led to a reduction in its safety dose and imposition of ban on its use in infant feeding bottles. This restriction paved the way for the gradual market entry of its analogues. However, their structural similarity to BPA has put them under surveillance for endocrine disrupting potential. The application of these analogues is increasing and so are the studies reporting their toxicity. This review highlights the reasons which led to the ban of BPA and also reports the exposure and toxicological data available on its analogues. Hence, this compilation is expected to answer in a better way whether the replacement of BPA by these analogues is safer or more harmful?
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India.
Afia
A
Usman
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India. Electronic address: masoodamua@rediffmail.com.
Masood
M
Ahmad
D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D002648:Child; D002675:Child, Preschool; D003920:Diabetes Mellitus / Q000139:chemically induced; D052244:Endocrine Disruptors / Q000633:toxicity*; D004703:Endocrine System / Q000187:drug effects; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000633:toxicity; D006331:Heart Diseases / Q000139:chemically induced; D006795:Household Products; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009765:Obesity / Q000139:chemically induced; D018384:Oxidative Stress; D010636:Phenols / Q000633:toxicity*; D010969:Plastics / Q000009:adverse effects*; D012449:Safety; D013450:Sulfones / Q000633:toxicity; D000098833:Bisphenol F Compounds; D000098923:Bisphenol B Compounds; D000098831:Bisphenol S Compounds; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D010636:Phenols; D010969:Plastics; D013450:Sulfones; C000611646:bisphenol F; D000098833:Bisphenol F Compounds; C492482:bisphenol B; D000098923:Bisphenol B Compounds; C543008:bisphenol S; D000098831:Bisphenol S Compounds; C006780:bisphenol A; D000098826:Bisphenol A Compounds
Analogues; Bisphenols; Endocrine disruption; Toxicity