Plasma Levels of hsa-miR-619-5p and hsa-miR-1184 Differ in Prostatic Benign Hyperplasia and Cancer.
Peripheral blood plasma profiles of circulating microRNA expression were analyzed in patients with prostatic cancer and benign hyperplasia. In prostatic cancer, significant increase in hsa-miR-619-5p and hsa-miR-1184 microRNA expression and significant decrease in hsalet-7b-5p and hsa-let-7c-5p microRNA expression were observed. The role of the relationship between the microRNA expression and the activities and functions of host genes with introns encoding these microRNA is discussed.
BioClinicum Center Research and Development Company, Moscow, Russia.
E N
EN
Knyazev
Medical Radiology Center, Moscow, Russia.
K A
KA
Fomicheva
Medical Radiology Center, Moscow, Russia.
D S
DS
Mikhailenko
Medical Radiology Center, Moscow, Russia.
K M
KM
Nyushko
BioClinicum Center Research and Development Company, Moscow, Russia.
T R
TR
Samatov
Medical Radiology Center, Moscow, Russia.
B Ya
BY
Alekseev
BioClinicum Center Research and Development Company, Moscow, Russia. mshkurnikov@imscs.msu.ru.|Medical Radiology Center, Moscow, Russia. mshkurnikov@imscs.msu.ru.
M Yu
MY
Shkurnikov
D014408:Biomarkers, Tumor / Q000097:blood*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000175:diagnosis; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis
D014408:Biomarkers, Tumor; C000597929:MIRN-619 microRNA, human; C000614093:MIRN1184 microRNA, human; D035683:MicroRNAs
benign prostatic hyperplasia; blood plasma; microRNA; microchip analysis; prostatic cancer