Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status.
OBJECTIVE
Gallbladder diseases and cholecystectomy may play a role in the development of colorectal cancer (CRC). Our aim was to investigate the association between cholecystectomy and CRC risk overall and by sex, family history, anatomical location, and tumor mismatch repair (MMR) status.


METHODS
This study comprised 5847 incident CRC cases recruited from population cancer registries in Australia, Canada, and the USA into the Colon Cancer Family Registry between 1997 and 2012 and 4970 controls with no personal history of CRC who were either randomly selected from the general population or were spouses of the cases. The association between cholecystectomy and CRC was estimated using logistic regression, after adjusting for confounding factors.


RESULTS
Overall, there was no evidence for an association between cholecystectomy and CRC (odds ratio [OR] = 0.88, 95 % confidence interval 0.73, 1.08). In the stratified analyses, there was no evidence for a difference in the association between women and men (P = 0.54), between individuals with and without family history of CRC in first-degree relative (P = 0.64), between tumor anatomical locations (P = 0.45), or between MMR-proficient and MMR-deficient cases (P = 0.54).


CONCLUSIONS
Cholecystectomy is not a substantial risk factor for CRC, regardless of sex, family history, anatomical location, or tumor MMR status.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Jie
J
Shang
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Jeanette C
JC
Reece
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.|Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia.
Daniel D
DD
Buchanan
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.|Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
Graham G
GG
Giles
Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Jane C
JC
Figueiredo
Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Graham
G
Casey
Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Steven
S
Gallinger
Molecular Genetics Laboratory, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Stephen N
SN
Thibodeau
Department of Health Science Research, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Noralane M
NM
Lindor
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.|School of Public Health, University of Washington, Seattle, WA, USA.
Polly A
PA
Newcomb
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.|School of Public Health, University of Washington, Seattle, WA, USA.|Centre for Public Health Research, Massey University, Wellington, New Zealand.
John D
JD
Potter
Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
John A
JA
Baron
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
John L
JL
Hopper
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Mark A
MA
Jenkins
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia. awin@unimelb.edu.au.
Aung Ko
AK
Win
D016022:Case-Control Studies; D002763:Cholecystectomy / Q000009:adverse effects*; D015179:Colorectal Neoplasms / Q000209:etiology*; D053843:DNA Mismatch Repair; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors
Cholecystectomy; Colorectal cancer; Gallbladder; Mismatch repair