CNDP1 genotype and renal survival in pediatric nephropathies.
BACKGROUND
The risk of developing type II diabetic nephropathy (DN) is lower in patients carrying the CNDP1 Mannheim polymorphism (homozygosity for the five leucine repeat), resulting in decreased activity of the histidine-dipeptide metabolizing enzyme carnosinase. The role of CNDP1 in other nephropathies is still unknown.


METHODS
To evaluate the impact of the CNDP1 Mannheim allele on pediatric chronic kidney disease (CKD), we prospectively followed the long-term clinical outcome of 272 children with non-diabetic kidney disease (glomerulopathies n=32, non-glomerular kidney disease n=240).


RESULTS
Renal failure progression was independent of CNDP1 genotype in the total cohort of CKD children. However, in patients with glomerulopathies, only 39% of patients homozygous for the CNDP1 Mannheim polymorphism attained the primary renal endpoint as compared to 77% of patients with any other CNDP1 genotype (p=0.06).


CONCLUSIONS
Our findings in pediatric CKD patients suggest that the nephroprotective effect of the CNDP1 Mannheim variant is not restricted to patients with diabetic nephropathy.
Verena
V
Peters
Moustafa
M
Kebbewar
Bart
B
Janssen
Georg F
GF
Hoffmann
Kristina
K
Möller
Simone
S
Wygoda
Marina
M
Charbit
Ana
A
Fernandes-Teixeira
Nikola
N
Jeck
Johannes
J
Zschocke
Claus Peter
CP
Schmitt
Franz
F
Schäfer
Elke
E
Wühl
D000293:Adolescent; D000483:Alleles; D002648:Child; D015331:Cohort Studies; D003131:Combined Modality Therapy; D004150:Dipeptidases / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D056726:Genetic Association Studies; D005921:Glomerulonephritis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D006720:Homozygote; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D012720:Severity of Illness Index; D016019:Survival Analysis
C522928:CNDP1 protein, human; D004150:Dipeptidases