Anxiolytic, Psychostimulant, and Analgesic Effects of Various Volumes of Ethanol Solution in Different Concentrations, but in the Same Dose.
We studied the effect of ethanol (dose 2 g/kg) in various concentrations (5, 13, and 40%) and different volumes (40, 15.5, and 5 ml/kg) on the level of anxiety, locomotor activity, and pain sensitivity in rats. Administration of 40 ml/kg water to animals was followed by a significant increase in the time spent in the open arms of the elevated plus maze. Administration of water in a volume of 5 or 15.5 ml/kg had little effect on the level of anxiety. The greater was the volume of intragastrically administered ethanol, the stronger was the anxiolytic effect. The psychostimulant and analgesic effects of ethanol were more pronounced after administration of medium volumes and intermediate concentrations of ethanol-containing solutions. Since administration of these solutions cannot produce maximum blood concentration of ethanol, we believe that the observed effects are mainly related to the direct effect of ethanol on the stomach tissue.
P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia. s-sudakov@nphys.ru.
S K
SK
Sudakov
P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
E V
EV
Alekseeva
P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
N G
NG
Bogdanova
P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
A A
AA
Kolpakov
P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia.
G A
GA
Nazarova
D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy*; D000431:Ethanol / Q000008:administration & dosage* / Q000627:therapeutic use*; D009043:Motor Activity / Q000187:drug effects; D010146:Pain / Q000188:drug therapy; D051381:Rats
D000700:Analgesics; D014151:Anti-Anxiety Agents; D000431:Ethanol
anxiety; ethanol; hot plate test; stomach