A sensitive determination of terbutaline in pharmaceuticals and urine samples using a composite electrode based on zirconium oxide nanoparticles.
An accurate and precise determination of terbutaline has been carried out using a glassy carbon electrode (GCE) modified with a composite of multi-walled carbon nanotubes (MWCNTs) and nanoparticles of zirconium oxide (ZrO2NPs). Energy dispersive X-ray and scanning electron microscopic techniques were utilized for the characterization of the composite layer. Terbutaline exhibited a broad oxidation peak at 770mV on a GCE. However, MWCNTs/GCE presented an electrocatalytic effect toward the oxidation of terbutaline with a better anodic peak at 660mV. Furthermore, the electrochemical behavior of terbutaline has greatly been improved at a GCE modified with a composite of MWCNTs and nanoparticles of ZrO2. The ZrO2NPs/MWCNTs/GCE exhibited a sharp anodic wave at 645mV with a large enhancement of the current response for terbutaline. Square wave voltammetry (SWV) was performed for the determination of terbutaline at ZrO2NPs/MWCNTs/GCE. A linear plot was obtained for the current responses of terbutaline against concentrations in the range of 10-160nM yielding a detection limit of 2.25nM (based on 3Sb/m). Improved voltammetric behavior, long-time stability and good reproducibility were obtained for terbutaline at the proposed electrode. A mean recovery of 101.2% with an RSD% of 1.9 was obtained for the analysis of the drug formulation. The accurate and precise quantification of terbutaline makes the ZrO2NPs/MWCNTs/GCE system of great interest for monitoring its therapeutic use.
Department of Chemistry, Harran University, Şanlıurfa 63510, Turkey.
Aysegul Kutluay
AK
Baytak
Department of Chemistry, Harran University, Şanlıurfa 63510, Turkey.
Tugce
T
Teker
Department of Chemistry, Harran University, Şanlıurfa 63510, Turkey.
Sehriban
S
Duzmen
Department of Chemistry, Harran University, Şanlıurfa 63510, Turkey. Electronic address: maslanoglu@harran.edu.tr.
Mehmet
M
Aslanoglu
D004566:Electrodes; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D013726:Terbutaline / Q000032:analysis*; D014556:Urine / Q000737:chemistry; D015040:Zirconium / Q000737:chemistry*
D015040:Zirconium; D013726:Terbutaline; C028541:zirconium oxide
Carbon nanotubes; Materials; Terbutaline; Zirconium oxide nanoparticles