Extranodal Lymphoma of the Central Nervous System and Spine.
With a strong predilection for immunocompromised groups and a poorly explained increase in prevalence among those with normal immune status, lymphoma now accounts for approximately 6% of all primary brain tumors. Recent advances in multiagent chemotherapy and monoclonal antibody therapy have promoted longer-term survival, although a definitive cure remains elusive. Extranodal lymphoma of the spine is more often caused by secondary dissemination from systemic disease and less often the primary site of origin. This article reviews a broad spectrum of clinical, etiologic, and pathologic features that frequently intersect with common radiologic findings of this disease.
Mayo Clinic, Department of Radiology, 200 First Street Southwest, Rochester, MN 55905, USA; American Institute for Radiologic Pathology, Neuroradiology Section, 1010 Wayne Avenue, Suite 320, Silver Spring, MD 20910, USA. Electronic address: koeller.kelly@mayo.edu.
Kelly K
KK
Koeller
American Institute for Radiologic Pathology, Neuroradiology Section, 1010 Wayne Avenue, Suite 320, Silver Spring, MD 20910, USA; Walter Reed National Military Medical Center, Department of Radiology, 8901 Rockville Pike, Bethesda, MD, 20889, USA; Uniformed Services University of the Health Sciences, Department of Radiology, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
Robert Y
RY
Shih
D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D019317:Evidence-Based Medicine; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D013120:Spinal Cord Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*
Immunosuppression; Intravascular lymphoma; Lymphomatoid granulomatosis; Lymphomatosis cerebri; Posttransplantation lymphoproliferative disorder; Primary central nervous system lymphoma