Comparison of adverse perinatal outcomes after single-needle and double-needle CVS techniques.
OBJECTIVE
To determine the impact of the chorion villus sampling (CVS) technique on adverse perinatal outcomes.


METHODS
In this case-control study, 412 women who underwent CVS at 11-14 weeks of gestation and 231 women who did not undergo any invasive procedure were retrospectively evaluated. The women in the CVS group were further divided into two groups according to the use of single-needle technique (n=148) vs. double-needle technique (n=264). The adverse outcomes were compared between controls and the two CVS groups, and regression analysis was used to determine the significance of independent contribution.


RESULTS
The rate of preeclampsia for the control group was 2.2%, for the double-needle group was 3% and for the single-needle group was 8.1%. CVS with single-needle technique was found to be an independent and statistically significant risk factor for preeclampsia [odds ratio (OR)=2.1, 95% confidence interval (CI); 1.4-2.7, P=0.008].


CONCLUSIONS
The risk of preeclampsia after CVS appears to be increased with single-needle technique compared with double-needle technique.
Cenk
C
Gezer
Atalay
A
Ekin
Gokhan
G
Goynumer
Kaan
K
Pakay
Hicran
H
Acar
Ulas
U
Solmaz
Cuneyt Eftal
CE
Taner
Mehmet
M
Ozeren
D000328:Adult; D016022:Case-Control Studies; D015193:Chorionic Villi Sampling / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D055815:Young Adult