L1CAM: Cell adhesion and more.
L1CAM is a cell adhesion molecule of the immunoglobulin superfamily which was originally discovered as a major player in the development of the nervous system. L1CAM was demonstrated to have prognostic value in different cancers and to be a promising target for anti-cancer therapy. Here we overview the present data on L1CAM structure and function, regulation of its expression, role in cancer and therapeutic potential.
SRC Bioclinicum, Ugreshskaya str 2/85, 115088 Moscow, Russia; Moscow State University of Mechanical Engineering, Bolshaya Semenovskaya str 38, 107023 Moscow, Russia. Electronic address: t.samatov@bioclinicum.com.
Timur R
TR
Samatov
Institute of Anatomy and Experimental Morphology and University Cancer Center Hamburg (UCCH), University Medical-Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.
Daniel
D
Wicklein
Hertsen Federal Medical Research Centre of the Ministry of Health of the Russian Federation, Koroleva str 4, 249036 Obninsk, Russia; Moscow State University, Leninskie Gory, 119991 Moscow, Russia. Electronic address: tonevitsky@mail.ru.
Alexander G
AG
Tonevitsky
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002448:Cell Adhesion / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D005353:Fibronectins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D000070557:Immunoglobulin Domains / Q000235:genetics; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D039842:Neural Cell Adhesion Molecule L1 / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D005353:Fibronectins; D039842:Neural Cell Adhesion Molecule L1; D034741:RNA, Small Interfering
Cancer; Cell adhesion; Ig-like domains; L1CAM