Relevance of the Measles Virus Expression in Cancer - an Update.
Evidence of an association between classical Hodgkin lymphoma and the measles virus has previously been presented by our group. Arguments held against our thesis were reevaluated. Substantiation of a relationship between the measles virus and additional solid tumors was submitted. Moreover, a pathogenic pathway was suggested to support a possible contribution of the measles virus to the development of classical Hodgkin lymphoma. We have chosen to exclude a discussion of measles virotherapy, since this carries distinct implications. We now add new evidence regarding the expression of the measles virus phosphoprotein in a few cancers. We also suggest a role in this context for atypical measles syndrome in malignant tumors. Last, we propose a collaboration which may make the best, on the one hand of our cohort of classical Hodgkin lymphoma, half of which carry the measles virus expression in their tumor cells. The planned study will also look into the patients vaccination records and into a previous history of the measles disease. On the other hand, cohorts of patients diagnosed with late onset measles will be assessed for the eventual diagnosis of atypical measles syndrome and will be followed up for the subsequent development of a malignant tumor.
Departments of Pathology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, 1, Itzhak Rager Boulevard, P.O.Box 151, 84101, Beer-Sheva, Israel. dbenharroch@yahoo.com.
Daniel
D
Benharroch
Departments of Oncology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Samuel
S
Ariad
Department of Life Sciences, National Institute for Biotechnology in the Negev, Ben Gurion University of the Negev, Beer-Sheva, Israel.
Noa
N
Tadmor
Departments of Pathology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, 1, Itzhak Rager Boulevard, P.O.Box 151, 84101, Beer-Sheva, Israel.
Karen
K
Nalbandyan
Departments of Oncology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Irena
I
Lazarev
D000818:Animals; D006801:Humans; D008457:Measles / Q000150:complications* / Q000821:virology; D008459:Measles virus / Q000378:metabolism*; D009369:Neoplasms / Q000209:etiology* / Q000821:virology*; D010750:Phosphoproteins / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism
D010750:Phosphoproteins; D014764:Viral Proteins
Atypical measles syndrome; Breast cancer; Hodgkin lymphoma; Lung cancer; Measles virus