Cytokine profile in adult-onset Still's disease: Comparison with systemic juvenile idiopathic arthritis.
To compare pro-inflammatory cytokine profiles and kinetics in patients with adult-onset Still's disease (AOSD) to those in patients with systemic juvenile idiopathic arthritis (s-JIA), we analyzed serum cytokine concentrations in 33 patients with AOSD and 77 patients with s-JIA and compared them with clinical features. Patients with AOSD and s-JIA shared a common cytokine profile pattern of a significant increase in IL-18. Patients with AOSD were classified into two subgroups based on serum IL-6 and IL-18 levels. The number of patients with arthritis was significantly higher in the IL-6-dominant subgroup. The cytokine patterns associated with s-JIA and AOSD share common features, such as a significant and predominant increase in IL-18. Distinct IL-6- and IL-18-based cytokine profiles might be responsible for distinct clinical manifestations. The presence of two distinct subgroups in patients with both diseases further supports the view that s-JIA and AOSD share a disease category.
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
Natsumi
N
Inoue
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan. Electronic address: shimizum@staff.kanazawa-u.ac.jp.
Masaki
M
Shimizu
Division of Rheumatology, Department of Internal Medicine, Hyogo, College of Medicine, Nishinomiya, Japan.
Shinichiro
S
Tsunoda
Division of Rheumatology, Department of Internal Medicine, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Mitsuhiro
M
Kawano
Division of General Internal Medicine, Jichi Medical University Hospital, Shimotsuke, Japan.
Masami
M
Matsumura
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.
Akihiro
A
Yachie
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D055501:Macrophage Activation Syndrome / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D016706:Still's Disease, Adult-Onset / Q000097:blood* / Q000150:complications / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D020382:Interleukin-18; D015850:Interleukin-6; D011239:Prednisolone
Adult-onset Still's disease; Interleukin-18; Macrophage activation syndrome; Systemic juvenile idiopathic arthritis