No Association of the rs17822931 Polymorphism in ABCC11 with Breast Cancer Risk in Koreans.
ABCC11 is reported to be associated with breast cancer. However, whether ABCC11 polymorphisms relate to breast cancer risk remains unclear. This study aimed to evaluate any association of a single nucleotide polymorphism (SNP), rs17822931, in ABCC11 with breast cancer in Koreans. Genomic DNA samples of 170 women with breast cancer and 100 controls were assessed for SNP rs17822931 of ABCC11 by single-strand conformation polymorphism (SSCP) and DNA sequencing. A 27-bp deletion (Δ27) of ABCC11 was analyzed by PCR amplification. The genotype of SNP rs17822931 was confirmed to be AA in all samples from breast cancer patients and Δ27 was found in none of the samples. Our finding indicated that the SNP rs17822931 in ABCC11 is not associated with breast cancer. However, this study does provide information on fundamental genetic aspects of ABCC11 with regard to breast cancer risk in Koreans.
Department of Medical Genetics, Hanvit Institution for Medical Genetics, Keimyung University, Daegu, Republic of Korea E-mail : dkkimmd@kmu.ac.kr.
Ann-Yae
AY
Na
Jin-Chul
JC
Heo
Jin Young
JY
Sung
Jong-Ha
JH
Lee
Yoon-Nyun
YN
Kim
Dae-Kwang
DK
Kim
D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D011379:Prognosis; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors
C435500:ABCC11 protein, human; D018528:ATP-Binding Cassette Transporters; D014408:Biomarkers, Tumor