Cortical and vestibular stimulation reveal preserved descending motor pathways in individuals with motor-complete spinal cord injury.
OBJECTIVE
To use a combination of electrophysiological techniques to determine the extent of preserved muscle activity below the clinically-defined level of motor-complete spinal cord injury.


METHODS
Transcranial magnetic stimulation and vestibular-evoked myogenic potentials were used to investigate whether there was any preserved muscle activity in trunk, hip and leg muscles of 16 individuals with motor-complete spinal cord injury (C4-T12) and 16 able-bodied matched controls.


RESULTS
Most individuals (14/16) with motor-complete spinal cord injury were found to have transcranial magnetic stimulation evoked, and/or voluntary evoked muscle activity in muscles innervated below the clinically classified lesion level. In most cases voluntary muscle activation was accompanied by a present transcranial magnetic stimulation response. Furthermore, motor-evoked potentials to transcranial magnetic stimulation could be observed in muscles that could not be voluntarily activated. Vestibular-evoked myogenic potentials responses were also observed in a small number of subjects, indicating the potential preservation of other descending pathways.


CONCLUSIONS
These results highlight the importance of using multiple electrophysiological techniques to assist in determining the potential preservation of muscle activity below the clinically-defined level of injury in individuals with a motor-complete spinal cord injury. These techniques may provide clinicians with more accurate information about the state of various motor pathways, and could offer a method to more accurately target rehabilitation.
School of Kinesiology, University of British Columbia, Vancouver, BC, Canada.
Jordan W
JW
Squair
Anna
A
Bjerkefors
J Timothy
JT
Inglis
Tania
T
Lam
Mark G
MG
Carpenter
D000328:Adult; D016022:Case-Control Studies; D004525:Efferent Pathways / Q000503:physiopathology; D004599:Electric Stimulation Therapy / Q000379:methods*; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D006615:Hip / Q000294:innervation*; D006801:Humans; D007866:Leg / Q000294:innervation*; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation; D013119:Spinal Cord Injuries / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods