Enantioselective Recognition by Chiral Supramolecular Gels.
Chiral supramolecular gels, in which small organic molecules self-assemble into chiral nanostructures and entangle each other to immobilize solvents through various noncovalent interactions, can work as a matrix for enantioselective recognition on chiral analytes. Through gelation and the formation of well-defined nanostructures, the chiral sense of the component molecules can be accumulated or amplified, and thus, the enantioselective recognition ability can be enhanced. Furthermore, a chiral microenvironment formed in the gel networks could provide additional stereochemical recognition geometry and attribute to efficient recognition. In this focus review, enantioselective recognition on chiral analytes through chiral supramolecular gels, with either amplified signals or the gel-sol phase transition, is discussed. This review is expected to provide useful insights into the design and fabrication of supramolecular gel systems with chiral features and high enantioselectivity.
Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Colloid, Interface, and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China.
Li
L
Zhang
Henan Provincial Key Laboratory of Surface and Interface Science, Zhengzhou University of Light Industry, Zhengzhou, Henan, 450002, P.R. China.
Qingxian
Q
Jin
Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Colloid, Interface, and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China. liumh@iccas.ac.cn.
Minghua
M
Liu
chirality; enantioselectivity; gels; molecular recognition; supramolecular chemistry