Hepatitis E in post-liver transplantation: is it time to routinely consider it?
Hepatitis E, although commonly recognized in the Eastern Hemisphere, is less well recognized in the West. Particularly owing to this disease's grave impact on outcomes after liver transplantation, greater consideration of hepatitis E is necessary in the context of abnormal liver tests. Here, we review the most recent data on detecting and managing hepatitis E, both pre- and post-liver transplantation, discuss major detection assay limitations, consider future directions, and propose an algorithm for the diagnosis and management of pre-and post-transplantation hepatitis E.
Division of Digestive Diseases, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA. bborg@umc.edu.
Brian B
BB
Borg
Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.|Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA.
Zongdi
Z
Feng
Division of Transplant and Hepatobiliary Surgery, Department of Surgery, University of Mississippi Medical Center, Jackson, MS, USA.
Truman M
TM
Earl
Division of Transplant and Hepatobiliary Surgery, Department of Surgery, University of Mississippi Medical Center, Jackson, MS, USA.
Christopher D
CD
Anderson
D003938:Diagnostic Techniques, Digestive System; D019468:Disease Management; D014943:Global Health; D016751:Hepatitis E / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D016752:Hepatitis E virus / Q000235:genetics*; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012367:RNA, Viral / Q000032:analysis*
D012367:RNA, Viral
hepatitis E; liver transplantation