miR-21-5p renal expression is associated with fibrosis and renal survival in patients with IgA nephropathy.
IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis, whose prognosis is highly variable. Interstitial fibrosis is a strong independent prognosis factor. Among microRNA involved in renal fibrogenesis, only few have been investigated in IgAN. In the context of IgAN, we aimed to analyze the role of miR-21-5p, miR-214-3p and miR-199a-5p, three established "fibromiRs" involved in renal fibrosis. Fifty-six IgAN biopsy specimens were retrospectively scored according to Oxford classification. Renal expression of miR-21-5p, miR-214-3p and miR-199a-5p were significantly associated with T score (miR-21-5p T0 RQ median = 1.23, T1 RQ = 3.01, T2 RQ = 3.90; miR-214-5p T0 RQ = 1.39, T1 RQ = 2.20, T2 RQ = 2.48; miR-199a-5p T0 RQ = 0.76, T1 RQ = 1.41, T2 RQ = 1.87). miR-21-5p expression was associated with S score (S0 RQ median = 1.31, S1 RQ = 2.65), but not miR-214-3p nor miR-199a-5p. In our cohort, poor renal survival was associated with high blood pressure, proteinuria and elevated creatininemia, as well as T and S scores. Moreover, renal expression of miR-21-5p, miR-214-3p were associated with renal survival. In conclusion, miR-21-5p, miR-214-3p and miR-199a-5p are three "fibromiRs" involved in renal fibrosis in the course of IgAN and miR-21-5p and miR-214-3p are associated with renal survival.
Univ. Lille, CHU Lille - Service de néphrologie, Institut Pasteur de Lille, EA 4483 - IMPECS - IMPact of Environmental ChemicalS on human health, F-59000 Lille, France.|Centre Hospitalier de Valenciennes - Service de néphrologie, médecine interne et vasculaire, F-59300 Valenciennes, France.
Marie-Flore
MF
Hennino
Sorbonne Universités, UPMC Paris 06, Inserm, AP-HP, Hôpital Tenon, Pathology Department, UMR S 1155, F-75020 Paris, France.
David
D
Buob
Univ. Lille, CHU Lille - Service de néphrologie, Institut Pasteur de Lille, EA 4483 - IMPECS - IMPact of Environmental ChemicalS on human health, F-59000 Lille, France.
Cynthia
C
Van der Hauwaert
Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000 Lille, France.
Viviane
V
Gnemmi
Centre Hospitalier de Cambrai - Service de néphrologie, F-59400 Cambrai, France.
Zacharie
Z
Jomaa
Univ. Lille, CHU Lille - Service de néphrologie, Institut Pasteur de Lille, EA 4483 - IMPECS - IMPact of Environmental ChemicalS on human health, F-59000 Lille, France.
Nicolas
N
Pottier
Univ. Lille, CHU Lille - Service de néphrologie, Institut Pasteur de Lille, EA 4483 - IMPECS - IMPact of Environmental ChemicalS on human health, F-59000 Lille, France.
Grégoire
G
Savary
Univ. Lille, CHU Lille, EA 2694 - Santé publique: épidémiologie et qualité des soins, F-59000 Lille, France.
Elodie
E
Drumez
Univ. Lille, Inserm, CHU Lille - Service de néphrologie, U995 - LIRIC - Lille Inflammation Research International Center, F-59000 Lille, France.
Christian
C
Noël
Univ. Lille, CHU Lille - Service de néphrologie, Institut Pasteur de Lille, EA 4483 - IMPECS - IMPact of Environmental ChemicalS on human health, F-59000 Lille, France.
Christelle
C
Cauffiez
Univ. Lille, CHU Lille - Service de néphrologie, Institut Pasteur de Lille, EA 4483 - IMPECS - IMPact of Environmental ChemicalS on human health, F-59000 Lille, France.
François
F
Glowacki
D000328:Adult; D005260:Female; D005355:Fibrosis; D005922:Glomerulonephritis, IGA / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D012307:Risk Factors; D015854:Up-Regulation; D055815:Young Adult
C524940:MIRN21 microRNA, human; D035683:MicroRNAs