Quantitative evaluation of gadoxetate hepatocyte phase homogeneity: potential imaging markers for detection of early cirrhosis.
OBJECTIVE
Does quantitative analysis of the gadoxetate hepatocyte phase homogeneity, measuring percent standard deviation of hepatocyte phase (SDHP) and liver-to-kidney enhancement ratio (LiKER) detect early hepatic fibrosis?


METHODS
Retrospective review of gadoxetate liver MRI plus biopsy-proven fibrosis within 6 months included 31 reversible hepatic fibrosis, 33 irreversible hepatic fibrosis, and 15 donors. Parenchymal and vascular SDHP and LiKER were measured on the 20-min hepatocyte phase using region of interest.


RESULTS
Parenchymal SDHP, vascular SDHP and LiKER measurements differentiate early hepatic fibrosis from controls (P<.01).


CONCLUSIONS
Quantitative analysis of gadoxetate hepatocyte phase homogeneity using SDHP and LiKER is a promising imaging biomarker for diagnosis of early liver fibrosis.
Department of Radiology, Weill Cornell Medical College and New York Presbyterian Hospital, New York, NY, 10065. Electronic address: srb9017@med.cornell.edu.
Srikanth
S
Boddu
Department of Radiology, Weill Cornell Medical College and New York Presbyterian Hospital, New York, NY, 10065. Electronic address: dob9035@med.cornell.edu.
Douglas
D
Brylka
Department of Radiology, Weill Cornell Medical College and New York Presbyterian Hospital, New York, NY, 10065. Electronic address: spd9005@nyp.org.
Silvina P
SP
Dutruel
Department of Radiology, Weill Cornell Medical College and New York Presbyterian Hospital, New York, NY, 10065. Electronic address: pas2018@med.cornell.edu.
Pascal
P
Spincemaille
Department of Radiology, Weill Cornell Medical College and New York Presbyterian Hospital, New York, NY, 10065. Electronic address: map2008@med.cornell.edu.
Martin R
MR
Prince
D000328:Adult; D015415:Biomarkers; D001706:Biopsy; D016022:Case-Control Studies; D003287:Contrast Media / Q000493:pharmacokinetics*; D005260:Female; D019786:Gadolinium DTPA / Q000493:pharmacokinetics*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D055815:Young Adult
D015415:Biomarkers; D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
Gadoxetate disodium; Liver fibrosis; Liver-to-kidney enhancement ratio (LiKER); Quantitative analysis; Region-of-interest (ROI) analysis; Standard deviation of hepatocyte phase (SDHP)