The rate of training response to aerobic exercise affects brain function of rats.
There is an increasing volume of data connecting capacity to respond to exercise training with quality of life and aging. In this study, we used a rat model in which animals were selectively bred for low and high gain in running distance to test t whether genetic segregation for trainability is associated with brain function and signaling processes in the hippocampus. Rats selected for low response (LRT) and high response training (HRT) were randomly divided into control or exercise group that trained five times a week for 30 min per day for three months at 70% VO2max. All four groups had similar running distance before training. With training, HRT rats showed significantly greater increases in VO2max and running distance than LRT rats (p < 0.05). On the reverse Morris Maze test HRT-trained rats outperformed HRT control ones. Significant difference was noted between LRT and HRT groups in redox milieu as assessed by levels of reactive oxygen species (ROS), carbonylation of proteins, nNOS and S-nitroso-cysteine. Moreover the silent information regulator 1 (SIRT1), brain-derived neurotrophic factor (BDNF), ratio of phospho and total cAMP-response element binding protein (CREB), and apoptotic index, also showed significant differences between LRT and HRT groups. These findings suggest that aerobic training responses are not localized to skeletal muscle, but differently involve signaling processes in the brain of LRT and HRT rats.
Research Institute of Sport Science, University of Physical Education, Budapest, Hungary.
Orsolya
O
Marton
Research Institute of Sport Science, University of Physical Education, Budapest, Hungary.
Erika
E
Koltai
Research Institute of Sport Science, University of Physical Education, Budapest, Hungary.
Masaki
M
Takeda
Research Institute of Sport Science, University of Physical Education, Budapest, Hungary.
Tatsuya
T
Mimura
Research Institute of Sport Science, University of Physical Education, Budapest, Hungary.
Melitta
M
Pajk
Research Institute of Sport Science, University of Physical Education, Budapest, Hungary.
Dora
D
Abraham
Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Lauren Gerard
LG
Koch
Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Steven L
SL
Britton
Graduate School of Sport Sciences, Waseda University, Saitama, Japan.
Mitsuru
M
Higuchi
Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Istvan
I
Boldogh
Research Institute of Sport Science, University of Physical Education, Budapest, Hungary; Institute of Sport Sciences and Physical Education, University of Pecs, Pecs, Hungary. Electronic address: radak@tf.hu.
Zsolt
Z
Radak
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001921:Brain / Q000502:physiology*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D005080:Exercise Test / Q000379:methods*; D006624:Hippocampus / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000379:methods* / Q000502:physiology*; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism
D019208:Brain-Derived Neurotrophic Factor; D017382:Reactive Oxygen Species
Brain derived neurotrophic factor; Brain function; Exercise; Redox signaling; Trainability