Two new cyclopentenones and a new furanone from Baeckea frutescens and their cytotoxicities.
Two new cyclopentenones, frutescencenones A (1) and B (2), and a new furanone derivative, frutescencenone C (3), together with two known cyclopentenones (4 and 5), were isolated from the leaves of Baeckea frutescens. Their structures were deduced by comprehensive spectroscopic analyses, including 1D and 2D NMR, and HREIMS data. Frutescencenone A (1) showed moderate growth inhibitory activity against human lung A549, pancreatic PSN-1, and breast MDA-MB-231 cancer cell lines, with IC50 values of 36.3μM, 38.2μM, and 29.3μM, respectively. In contrast, frutescencenone C (3) showed selective cytotoxic activity against PSN-1, with an IC50 value of 20.1μM.
Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan. Electronic address: itot@inm.u-toyama.ac.jp.
Takuya
T
Ito
Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan; Research Unit for Development of Chemical Engineering Processes, Indonesian Institute of Sciences (LIPI), Jl. Jogja-Wonosari Km. 32, Playen, Gunungkidul, Yogyakarta 55861, Indonesia.
Khoirun
K
Nisa
Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan.
Takeshi
T
Kodama
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
Masami
M
Tanaka
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
Yasuko
Y
Okamoto
Faculty of Pharmacy, Hasanuddin University, Makassar 90245, South Sulawesi, Indonesia.
Ismail
Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan. Electronic address: hmorita@inm.u-toyama.ac.jp.
Hiroyuki
H
Morita
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D003517:Cyclopentanes / Q000737:chemistry* / Q000302:isolation & purification; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D027822:Myrtaceae / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D003517:Cyclopentanes; D005663:Furans; C013905:cyclopentenone
Baeckea frutescens; Cyclopentenone; Cytotoxic activity; Furanone; Myrtaceae