Polyoxypregnane Glycosides from the Roots of Marsdenia tenacissima and Their Anti-HIV Activities.
A continuous phytochemical study on the roots ofMarsdenia tenacissimaled to the isolation and identification of 13 new polyoxypregnane glycosides named marstenacissides B10-B17 (1, 2, 4, 7, 8, 11, 12, and14) and marstenacissides A8-A12 (3, 9, 10, 13, and15) in addition to two known polyoxypregnane glycosides marsdenosides M and L (5and6). Their structures were established by spectroscopic techniques and by comparison with the reported data in the literature. Moreover, the anti-HIV activities of these isolates and the previous isolated marstenacissides A1-A7 and B1-B9 were assessed, some of which exhibited slight or negligible effects against HIV-1.
Beijing Institute of Radiation Medicine, Beijing, China.
Xu
X
Pang
Beijing Institute of Radiation Medicine, Beijing, China.
Li-Ping
LP
Kang
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Xiao Mei
XM
Fang
Beijing Institute of Radiation Medicine, Beijing, China.
Yang
Y
Zhao
Tianjin University of Traditional Chinese Medicine, Tianjin, China.
He-Shui
HS
Yu
Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Li-Feng
LF
Han
Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong, China.
Hai-Tao
HT
Li
Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong, China.
Li-Xia
LX
Zhang
Institute of Medicinal Plant development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Bao-Lin
BL
Guo
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Li-Yan
LY
Yu
Beijing Institute of Radiation Medicine, Beijing, China.
Bai-Ping
BP
Ma
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects*; D031101:Marsdenia / Q000737:chemistry*; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
C575295:12-0-benzoyl-8,11-ditigloyl-3,8,11,12-pentahydroxy-pregn-14-ol, 20-one 3-0-methyl-allopyranosyl(1-4)-thevetopyranoside; D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D012503:Saponins