Dipeptide Piracetam Analogue Noopept Improves Viability of Hippocampal HT-22 Neurons in the Glutamate Toxicity Model.
Effect of noopept (N-phenylacetyl-prolylglycine ethyl ester) on viability of neurons exposed to neurotoxic action of glutamic acid (5 mM) was studied in vitro in immortalized mouse hippocampal HT-22 neurons. Noopept added to the medium before or after glutamic acid improved neuronal survival in a concentration range of 10-11-10-5 M. Comparison of the effective noopept concentrations determined in previous studies on cultured cortical and cerebellar neurons showed that hippocampal neurons are more sensitive to the protective effect of noopept.
V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
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Antipova
V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. cergej.nikolajev@gmail.com.
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Nikolaev
V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
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Ostrovskaya
V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
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Gudasheva
V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
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Seredenin
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004151:Dipeptides / Q000494:pharmacology*; D018698:Glutamic Acid / Q000633:toxicity*; D051379:Mice; D009474:Neurons / Q000166:cytology* / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010889:Piracetam / Q000031:analogs & derivatives*
D004151:Dipeptides; D018696:Neuroprotective Agents; D018698:Glutamic Acid; C103871:ethyl phenylacetyl-Pro-Gly; D010889:Piracetam
HT-22 culture; dipeptides; glutamate toxicity; neuroprotection; noopept