A Bioprinted Liver-on-a-Chip for Drug Screening Applications.
The need for a liver-on-a-chip tissue model for drug screening is particularly important in tissue engineering because of the high frequency of drug-induced liver injury. Recently, a liver tissue model conducive to hepatotoxicity testing was developed by bioprinting hepatic spheroids encapsulated in a hydrogel scaffold into a microfluidic device.
Department of Biomedical Engineering, University of Connecticut, 260 Glenbrook Road, Storrs, CT 06269, USA.
Stephanie
S
Knowlton
Department of Biomedical Engineering, University of Connecticut, 260 Glenbrook Road, Storrs, CT 06269, USA; Department of Mechanical Engineering, University of Connecticut, 191 Auditorium Road, Storrs, CT 06269, USA. Electronic address: savas@engr.uconn.edu.
Savas
S
Tasoglu
D062028:Bioprinting / Q000295:instrumentation*; D018929:Cell Culture Techniques / Q000295:instrumentation*; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D056945:Hep G2 Cells; D022781:Hepatocytes / Q000166:cytology; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D056656:Lab-On-A-Chip Devices; D008099:Liver / Q000166:cytology*; D008954:Models, Biological; D018874:Spheroids, Cellular / Q000166:cytology; D023822:Tissue Engineering
D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
3D cell cultures; bioprinting; liver tissue engineering; microfluidics; organ-on-a-chip; tissue engineering