Association of Choroidal Interleukin-17-Producing T Lymphocytes and Macrophages with Geographic Atrophy.
OBJECTIVE
To evaluate the presence of interleukin-17 (IL-17)-producing cells in patients with geographic atrophy (GA).


METHODS
In this short report, we analyzed IL-17, CD3, and IBA-1 expression by immunohistochemistry on paraffin-embedded sections from 13 donors with a known history of GA, confirmed by fundus appearance and histology, and 7 age-matched control donors.


CONCLUSIONS
We showed that IL-17+ cells are found near areas of retinal pigmented epithelium atrophy in the eyes of GA patients. IL-17+ cells mainly localized to CD3+ cells, which identifies T lymphocytes, as well as IBA-1+ cells, which identifies mononuclear phagocytes. Therefore, IL-17 could be involved in the pathological mechanisms that contribute to the degeneration observed in GA.
Unitx00E9; de Recherche Clinique Lariboisix00E8;re Saint-Louis, AP-HP, Paris, France.
Serge
S
Camelo
Sophie
S
Lavelette
Xavier
X
Guillonneau
William
W
Raoul
Florian
F
Sennlaub
D000369:Aged, 80 and over; D002829:Choroid / Q000276:immunology / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D057092:Geographic Atrophy / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular; D007150:Immunohistochemistry; D020381:Interleukin-17 / Q000096:biosynthesis*; D008264:Macrophages / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
D020381:Interleukin-17