The potential association between obesity and bipolar disorder: A meta-analysis.
Several epidemiological studies have found that the prevalence of bipolar disorder (BD) is significantly higher in obese population than non-obese population. However, no meta-analysis has been published to quantitatively summarize the related literature.



In this study, we conducted a meta-analysis to explore the association between obesity and BD by combining 9 cross-sectional studies with a total of 12,259 BD cases and 615,490 non-BD controls. The meta-analysis was performed using the effect estimates and 95% confidence intervals (CIs) to calculate the pooled odds ratio (OR), while the heterogeneity was assessed using I(2) and Q statistic.



Our meta-analysis suggests that obesity is associated with increased prevalence of BD by a random-effect model (OR=1.77, 95% CI: 1.40-2.23; Q=44.62, P<0.001, I(2)=82.1%).



Without prospective studies, we cannot determine whether obesity increased the risk of developing BD or vice-versa.



Obesity is positively associated with BD.
Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; University of Texas Harris County Psychiatric Center, 2800 South MacGregor Way, Houston, TX 77021, USA. Electronic address: zxzhao1986@gmail.com.
Zhuoxian
Z
Zhao
University of Texas Harris County Psychiatric Center, 2800 South MacGregor Way, Houston, TX 77021, USA.
Olaoluwa O
OO
Okusaga
Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Neuroscience Graduate Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, USA; Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.
Joao
J
Quevedo
University of Texas Harris County Psychiatric Center, 2800 South MacGregor Way, Houston, TX 77021, USA; Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Neuroscience Graduate Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, USA.
Jair C
JC
Soares
Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; University of Texas Harris County Psychiatric Center, 2800 South MacGregor Way, Houston, TX 77021, USA. Electronic address: antonio.l.teixeira@uth.tmc.edu.
Antonio L
AL
Teixeira
D001714:Bipolar Disorder / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015233:Models, Statistical; D009765:Obesity / Q000150:complications* / Q000523:psychology; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors
Bipolar disorder; Meta-analysis; Obesity