The BOLD cerebrovascular reactivity response to progressive hypercapnia in young and elderly.
Blood Oxygenation Level Dependent (BOLD) imaging in combination with vasoactive stimuli can be used to probe cerebrovascular reactivity (CVR). Characterizing the healthy, age-related changes in the BOLD-CVR response can provide a reference point from which to distinguish abnormal CVR from the otherwise normal effects of ageing. Using a computer controlled gas delivery system, we examine differences in BOLD-CVR response to progressive hypercapnia between 16 young (28±3years, 9 female) and 30 elderly subjects (66±4years, 13 female). Furthermore, we incorporate baseline T2* information to broaden our interpretation of the BOLD-CVR response. Significant age-related differences were observed. Grey matter CVR at 7mmHg above resting PetCO2was lower amongst elderly (0.19±0.06%ΔBOLD/mmHg) as compared to young subjects (0.26±0.07%ΔBOLD/mmHg). White matter CVR at 7mmHg above baseline PetCO2showed no significant difference between young (0.04±0.02%ΔBOLD/mmHg) and elderly subjects (0.05±0.03%ΔBOLD/mmHg). We saw no significant differences in the BOLD signal response to progressive hypercapnia between male and female subjects in either grey or white matter. The observed differences in the healthy BOLD-CVR response could be explained by age-related changes in vascular mechanical properties.
Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: a.bhogal@umcutrecht.nl.
Alex A
AA
Bhogal
Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Jill B
JB
De Vis
Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Jeroen C W
JCW
Siero
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark.
Esben T
ET
Petersen
Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Peter R
PR
Luijten
Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Jeroen
J
Hendrikse
Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Marielle E P
MEP
Philippens
Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Hans
H
Hoogduin
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D001783:Blood Flow Velocity; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D057054:Molecular Imaging / Q000379:methods; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption
D010100:Oxygen