A doxorubicin delivery system: Samarium/mesoporous bioactive glass/alginate composite microspheres.
Samarium (Sm) incorporated mesoporous bioactive glasses (MBG) microspheres have been prepared using the method of alginate cross-linking with Ca(2+) ions. The in vitro bioactivities of Sm/MBG/alginate microspheres were studied by immersing in simulated body fluid (SBF) for various periods. The results indicated that the Sm/MBG/alginate microspheres have a faster apatite formation rate on the surface. To investigate their delivery properties further, doxorubicin (DOX) was selected as a model drug. The results showed that the Sm/MBG/alginate microspheres exhibit sustained DOX delivery, and their release mechanism is controlled by Fickian diffusion according the Higuchi model. In addition, the delivery of DOX from Sm/MBG/alginate microspheres can be dominated by changing the doping concentration of Sm and the values of pH microenvironment. These all revealed that this material is a promising candidate for the therapy of bone cancer.
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China. Electronic address: yingzhang@suda.edu.cn.
Ying
Y
Zhang
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China.
Xiang
X
Wang
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China.
Yanli
Y
Su
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China.
Dongya
D
Chen
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China.
Wenxing
W
Zhong
D000464:Alginates / Q000737:chemistry*; D001031:Apatites / Q000737:chemistry; D004317:Doxorubicin / Q000494:pharmacology*; D016503:Drug Delivery Systems / Q000379:methods*; D005898:Glass / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007477:Ions; D007700:Kinetics; D016014:Linear Models; D008863:Microspheres; D016062:Porosity; D011208:Powders; D012493:Samarium / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
D000464:Alginates; D001031:Apatites; D006603:Hexuronic Acids; D007477:Ions; D011208:Powders; D012493:Samarium; D004317:Doxorubicin; D020723:Glucuronic Acid
Doxorubicin release; Mesoporous bioactive glasses; Samarium