Early Zinc Supplementation and Enhanced Growth of the Low-Birth Weight Neonate.
BACKGROUND
Nutritional deficits are almost universal in Low-Birth Weight babies. Zinc is essential for normal infant growth and its supplementation assists growth probably through insulin-like growth factor-1.


OBJECTIVE
This double-blind randomized-controlled trial aimed at evaluating the role of zinc in catch-up growth of low-birth-weight infants and investigating its proposed mediator.


METHODS
The study was conducted in Ain Shams University Maternity Hospital. Two hundred low-birth-weight neonates were simply randomized to either oral zinc therapy or placebo. Anthropometric measurements were recorded at birth, 3, 6, and 12 months; including weight, recumbent length, head, waist, chest, and mid-upper arm circumferences, and triceps and sub-scapular skin fold thickness.


RESULTS
We found that initial and 3-months measurements, except weight, were comparable in the 2 groups. All measurements at 6- and 12-months, except sub-scapular skin-fold-thickness, were significantly higher in zinc group than placebo. Catch-up growth, at 12-months, was significant in zinc group and was significantly higher in appropriate-for-gestational-age vs. small-for-gestational-age, in preterm vs. term, and in male vs. female infants. The median 6-months insulin-like growth factor-1 levels were significantly higher in zinc group.


CONCLUSIONS
We conclude that early start of oral zinc supplementation in low-birth-weight neonates assists catch-up growth, probably through rise of insulin-like growth factor-1.
Ain Shams University, Children's Hospital Cairo, Abbassia sq., Cairo 11351, Egypt.
Ola
O
El-Farghali
Ain Shams University, Children's Hospital Cairo, Abbassia sq., Cairo 11351, Egypt.
Mohamed Abd
MA
El-Wahed
National Research Centre - Biological Anthropology, National Research Centre, ElBuhose street, Dokki, Giza, Egypt.
Nayera E
NE
Hassan
Ain Shams University, Children's Hospital Cairo, Abbassia sq., Cairo 11351, Egypt.
Safaa
S
Imam
National Research Centre - Biological Anthropology, National Research Centre, ElBuhose street, Dokki, Giza, Egypt.
Khadija
K
Alian
catch-up growth; low birth weight; micronutrients; supplementation; zinc