Decreased Regional Cerebral Perfusion at Resting State in Acute Posttraumatic Stress Disorder Resulting From a Single, Prolonged Stress Event.
This study evaluated the altered regional cerebral blood flow (rCBF) in resting state in patients with acute posttraumatic stress disorder (PTSD) 3 months after trauma.



The rCBF was measured in 30 patients with acute PTSD and 36 healthy controls.



Survivors with acute PTSD showed decreased rCBF, the Clinician-Administered PTSD Scale score correlated negatively with the rCBF, and rCBF at resting state decreased in acute PTSD.



PTSD symptom severity was associated with diminished cerebral blood flow in the right insular cortex and right orbital medial frontal gyrus. The rCBF may predict PTSD symptom severity.
Department of Radiology, Xijing Hospital, Fourth Military Medical University, 17 Changle Road, Xi'an, Shaanxi 710032, China; Department of Radiology, Shaanxi People's Hospital, Xi'an, Shaanxi 710032, China.
Xia
X
Zhe
Department of Radiology, Xijing Hospital, Fourth Military Medical University, 17 Changle Road, Xi'an, Shaanxi 710032, China.
Kang
K
Liu
Department of Radiology, Xijing Hospital, Fourth Military Medical University, 17 Changle Road, Xi'an, Shaanxi 710032, China.
Yun-Feng
YF
Mu
Department of Radiology, Xijing Hospital, Fourth Military Medical University, 17 Changle Road, Xi'an, Shaanxi 710032, China.
Shun
S
Qi
Department of Radiology, Xijing Hospital, Fourth Military Medical University, 17 Changle Road, Xi'an, Shaanxi 710032, China.
Yi-Bin
YB
Xi
Department of Radiology, Xijing Hospital, Fourth Military Medical University, 17 Changle Road, Xi'an, Shaanxi 710032, China.
Ping
P
Du
Department of Radiology, Xijing Hospital, Fourth Military Medical University, 17 Changle Road, Xi'an, Shaanxi 710032, China.
Yi
Y
Huan
Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Qing-Rong
QR
Tan
Department of Radiology, Xijing Hospital, Fourth Military Medical University, 17 Changle Road, Xi'an, Shaanxi 710032, China. Electronic address: yinhong@fmmu.edu.cn.
Hong
H
Yin
Department of Radiology, Xijing Hospital, Fourth Military Medical University, 17 Changle Road, Xi'an, Shaanxi 710032, China.
Hai-Tao
HT
Zhao
Department of Radiology, Xijing Hospital, Fourth Military Medical University, 17 Changle Road, Xi'an, Shaanxi 710032, China.
Ya-Li
YL
Ge
Department of Radiology, Xijing Hospital, Fourth Military Medical University, 17 Changle Road, Xi'an, Shaanxi 710032, China.
Ying-Juan
YJ
Chang
D000208:Acute Disease; D000328:Adult; D001921:Brain / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002681:China; D004190:Disasters; D005260:Female; D055868:Floods; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012146:Rest; D012720:Severity of Illness Index; D013113:Spin Labels; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology* / Q000523:psychology; D017741:Survivors / Q000523:psychology / Q000706:statistics & numerical data*; D013995:Time
D013113:Spin Labels
Brain; MR imaging; arterial spin labeling; posttraumatic stress disorders; statistical parametric mapping