Inflammatory Response Using Different Lipid Parenteral Nutrition Formulas in Children After Hematopoietic Stem Cell Transplantation.
Nutritional support is an integral part of the supportive care of hematopoietic stem cell transplantation (HSCT) patients. Omega-3 fatty acids (n-3 FA) emulsions in parenteral nutrition (PN) may modify the inflammatory response. The purpose of this study is to compare plasma cytokine levels in children after HSCT using an n-3 FA-containing lipid emulsion (LE) and a soybean oil-based formulation in PN. A randomized double-blind controlled trial was conducted on 14 children following HSCT. Children were randomized to receive either a fish oil or a soybean oil LE. Blood samples were drawn at baseline, on Day 10 and after completion of PN to analyze plasma interleukin 1 beta (IL-1β), 2 (IL-2), 6 (IL-6), 8 (IL-8), 10 (IL-10), and tumor necrosis factor alpha (TNF-α). After 10 days of PN, there were no significant changes in interleukins levels when comparing the two groups or time points (baseline vs. Day 10 of PN). In children requiring PN >21 days, IL-10 and TNF-α levels (P ≤ 0.05) were lower in the fish-oil-containing LE group. Fish oil- and soybean oil-supplemented PN administered for at least 10 days does not cause inflammatory changes. Prolonged PN based on fish oil LE may modulate the inflammatory response.
a Department of Paediatrics , Unit of Paediatric Research, Reina Sofia University Hospital, Maimónides Institute of Biomedical Research of Córdoba (IMIBIC), University of Córdoba , Córdoba , Spain.
María Auxiliadora
MA
Baena-Gómez
a Department of Paediatrics , Unit of Paediatric Research, Reina Sofia University Hospital, Maimónides Institute of Biomedical Research of Córdoba (IMIBIC), University of Córdoba , Córdoba , Spain.
María José
MJ
de la Torre-Aguilar
b Department of Biochemistry and Molecular Biology II , Institute of Nutrition and Food Technology, Centre of Biomedical Research, University of Granada , Granada , Spain.
Concepción María
CM
Aguilera-García
b Department of Biochemistry and Molecular Biology II , Institute of Nutrition and Food Technology, Centre of Biomedical Research, University of Granada , Granada , Spain.
Josune
J
Olza
a Department of Paediatrics , Unit of Paediatric Research, Reina Sofia University Hospital, Maimónides Institute of Biomedical Research of Córdoba (IMIBIC), University of Córdoba , Córdoba , Spain.
Juan Luis
JL
Pérez-Navero
a Department of Paediatrics , Unit of Paediatric Research, Reina Sofia University Hospital, Maimónides Institute of Biomedical Research of Córdoba (IMIBIC), University of Córdoba , Córdoba , Spain.
Mercedes
M
Gil-Campos
D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood; D004311:Double-Blind Method; D004655:Emulsions; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D010288:Parenteral Nutrition; D057947:Parenteral Nutrition Solutions / Q000737:chemistry*; D013024:Soybean Oil / Q000008:administration & dosage
D016207:Cytokines; D004655:Emulsions; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D057947:Parenteral Nutrition Solutions; D013024:Soybean Oil