Antimicrobial Compounds from Drypetes staudtii.
Antimicrobial-directed phytochemical investigation of the MeOH extract of Drypetes staudtii afforded two new compounds, 4,5-(methylenedioxy)-o-coumaroylputrescine (1), 4,5-(methylenedioxy)-o-coumaroyl-4'-N-methylputrescine (2), along with seven known natural products 4α-hydroxyeremophila-1,9-diene-3,8-dione (3), drypemolundein B (4), friedelan-3β-ol (5), erythrodiol (6), ursolic acid (7), p-coumaric acid (8), and β-sitosterol (9). Structures of compounds 1 - 9 were elucidated with the aid of extensive NMR and mass spectral studies. All of the isolates exhibited antibacterial activity against Gram-positive and Gram-negative bacteria with minimum inhibitory concentration (MIC) in the range of 8 - 128 μg/ml. Compounds 1 - 2 were also moderately active against Candida albicans with an MIC value of 32 μg/ml.
Department of Chemistry, Richardson College for the Environmental and Science Complex, The University of Winnipeg, 599 Portage Avenue, Winnipeg, MB, R3B 2G3, Canada.
David
D
Grace
Department of Chemistry, Richardson College for the Environmental and Science Complex, The University of Winnipeg, 599 Portage Avenue, Winnipeg, MB, R3B 2G3, Canada.
Madiha S
MS
Khan
Department of Chemistry, Richardson College for the Environmental and Science Complex, The University of Winnipeg, 599 Portage Avenue, Winnipeg, MB, R3B 2G3, Canada.
Kenneth
K
Friesen
Department of Chemistry, Richardson College for the Environmental and Science Complex, The University of Winnipeg, 599 Portage Avenue, Winnipeg, MB, R3B 2G3, Canada. a.ata@uwinnipeg.ca.
Athar
A
Ata
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D019665:Euphorbiaceae / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009930:Organic Chemicals / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009930:Organic Chemicals
Antimicrobial activity; Candida albicans; Drypetes staudtii; Gram-negative bacteria; Gram-positive bacteria; Terpenoids