Dangerous Entrapment for NRF2.
Progerin, a mutated lamin A, causes the severe premature-aging syndrome Hutchinson-Gilford progeria (HGPS). Kubben et al. present a driving mechanism for HGPS involving trapping of NRF2 at the nuclear periphery by progerin. This local restriction results in impaired NRF2 signaling and chronic oxidative stress.
Department of Biology, 434 Hutchison Hall, River Campus, University of Rochester, Rochester, NY 14627, USA. Electronic address: vera.gorbunova@rochester.edu.
Vera
V
Gorbunova
Department of Biology, 434 Hutchison Hall, River Campus, University of Rochester, Rochester, NY 14627, USA.
Sarallah
S
Rezazadeh
Department of Biology, 434 Hutchison Hall, River Campus, University of Rochester, Rochester, NY 14627, USA.
Andrei
A
Seluanov
D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D034904:Lamin Type A / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism; D018384:Oxidative Stress; D011371:Progeria / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism
D034904:Lamin Type A; D009687:Nuclear Proteins; D011498:Protein Precursors