Preparation, property of the complex of carboxymethyl chitosan grafted copolymer with iodine and application of it in cervical antibacterial biomembrane.
Cervical erosion is one of the common diseases of women. The loop electrosurgical excisional procedure (LEEP) has been used widely in the treatment of the cervical diseases. However, there are no effective wound dressings for the postoperative care to protect the wound area from further infection, leading to increased secretion and longer healing time. Iodine is a widely used inorganic antibacterial agent with many advantages. However, the carrier for stable iodine complex antibacterial agents is lack. In the present study, a novel iodine carrier, Carboxymethyl chitosan-g-(poly(sodium acrylate)-co-polyvinylpyrrolidone) (CMCTS-g-(PAANa-co-PVP), was prepared by graft copolymerization of sodium acrylate (AANa) and N-vinylpyrrolidone (NVP) to a carboxymethyl chitosan (CMCTS) skeleton. The obtained structure could combine prominent property of poly(sodium acrylate) (PAANa) anionic polyelectrolyte segment and good complex property of polyvinylpyrrolidone (PVP) segment to iodine. The bioactivity of CMCTS could also be kept. The properties of the complex, CMCTS-g-(PAANa-co-PVP)-I2, were studied. The in vitro experiment shows that it has broad-spectrum bactericidal effects to virus, fungus, gram-positive bacteria and gram-negative bacteria. A CMCTS-g-(PAANa-co-PVP)-I2 complex contained cervical antibacterial biomembrane (CABM) was prepared. The iodine release from the CABM is pH-dependent. The clinic trial results indicate that CABM has better treatment effectiveness than the conventional treatment in the postoperative care of the LEEP operation.
School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, P.R. China.
Yu
Y
Chen
Zhejiang Sanchuang Biological Technology Co., Ltd., Jiaxing, Zhejiang Province 314031, P.R. China.
Yumin
Y
Yang
Zhejiang Sanchuang Biological Technology Co., Ltd., Jiaxing, Zhejiang Province 314031, P.R. China.
Qingping
Q
Liao
School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, P.R. China.
Wei
W
Yang
Zhejiang Sanchuang Biological Technology Co., Ltd., Jiaxing, Zhejiang Province 314031, P.R. China.
Wanfeng
W
Ma
Department of Gynaecology and Obstetrics, The First Hospital of Peking University, Beijing 100034, P.R. China.
Jian
J
Zhao
School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, P.R. China.
Xionggao
X
Zheng
Zhejiang Sanchuang Biological Technology Co., Ltd., Jiaxing, Zhejiang Province 314031, P.R. China.
Yang
Y
Yang
Department of Gynaecology and Obstetrics, The First Hospital of Peking University, Beijing 100034, P.R. China.
Rui
R
Chen
D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002584:Cervix Uteri / Q000187:drug effects*; D048271:Chitosan / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007455:Iodine / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008566:Membranes / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011108:Polymers / Q000494:pharmacology*; D011817:Rabbits; D012007:Rectum / Q000187:drug effects / Q000473:pathology; D018139:Simplexvirus / Q000187:drug effects; D012867:Skin / Q000187:drug effects; D013696:Temperature; D002579:Uterine Cervical Erosion / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects; D055815:Young Adult
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D011108:Polymers; C514968:carboxymethyl-chitosan; D048271:Chitosan; D007455:Iodine
Carboxymethyl chitosan; Cervical antibacterial biomembrane; Complex; Graft copolymer; Iodine; Postoperative care