Enhanced Visualization of Optimal Cerebral Perfusion Pressure Over Time to Support Clinical Decision Making.
Cerebrovascular reactivity can provide a continuously updated individualized target for management of cerebral perfusion pressure, termed optimal cerebral perfusion pressure. The objective of this project was to find a way of improving the optimal cerebral perfusion pressure methodology by introducing a new visualization method.



Four severe traumatic brain injury patients with intracranial pressure monitoring.



Data were collected and pre-processed using ICM+ software.



Sequential optimal cerebral perfusion pressure curves were used to create a color-coded maps of autoregulation - cerebral perfusion pressure relationship evolution over time.



The visualization method addresses some of the main drawbacks of the original methodology and might bring the potential for its clinical application closer.
1Department of Intensive Care, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.2Brain Physics Group, Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom.3Department of Technical Medicine, University of Twente, Enschede, The Netherlands.4Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.5Division of Anaesthesia, Department of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.6Research School of Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands.
Marcel J H
MJ
Aries
Robin
R
Wesselink
Jan Willem J
JW
Elting
Joseph
J
Donnelly
Marek
M
Czosnyka
Ari
A
Ercole
Natasha M
NM
Maurits
Peter
P
Smielewski
D001930:Brain Injuries / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D000066491:Clinical Decision-Making; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology*; D008991:Monitoring, Physiologic / Q000379:methods*; D015599:Trauma Severity Indices