Developmental and Functional Effects of Steroid Hormones on the Neuroendocrine Axis and Spinal Cord.
This review highlights the principal effects of steroid hormones at central and peripheral levels in the neuroendocrine axis. The data discussed highlight the principal role of oestrogens and testosterone in hormonal programming in relation to sexual orientation, reproductive and metabolic programming, and the neuroendocrine mechanism involved in the development of polycystic ovary syndrome phenotype. Moreover, consistent with the wide range of processes in which steroid hormones take part, we discuss the protective effects of progesterone on neurodegenerative disease and the signalling mechanism involved in the genesis of oestrogen-induced pituitary prolactinomas.
Instituto de Biología y Medicina Experimental-CONICET, Buenos Aires, Argentina.
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L
Zubeldia-Brenner
Department of Physiology and Pharmacology, Oregon Health and Science University Portland, Portland, OR, USA.
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CE
Roselli
Laboratory of Animal Physiology and Endocrinology, Faculty of Veterinary Sciences, University of Concepcion, Chillán, Chile.
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SE
Recabarren
Instituto de Biología y Medicina Experimental-CONICET, Buenos Aires, Argentina.|Departamento de Ciencias Fisiológicas, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
M C
MC
Gonzalez Deniselle
Laboratory of Neurobiochemistry Department of Biochemistry and Molecular Biology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile.
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HE
Lara
D000818:Animals; D063646:Carcinogenesis; D004967:Estrogens / Q000502:physiology*; D006801:Humans; D008660:Metabolism / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000503:physiopathology; D011374:Progesterone / Q000502:physiology*; D065840:Protective Factors; D012098:Reproduction / Q000502:physiology*; D012725:Sexual Behavior / Q000502:physiology*; D013116:Spinal Cord / Q000503:physiopathology*; D013739:Testosterone / Q000502:physiology*
D004967:Estrogens; D013739:Testosterone; D011374:Progesterone
androgens; hormonal programming; oestrogens; prolactin; steroid hormones