Important molecular genetic markers of colorectal cancer.
Colorectal cancer (CRC) ranks third in the incidences of cancer morbidity and mortality worldwide. CRC is rather heterogeneous with regard to molecular genetic characteristics and pathogenic pathways. A wide spectrum of biomarkers is used for molecular subtype determination, prognosis, and estimation of sensitivity to different drugs in practice. These biomarkers can include germline and somatic mutations, chromosomal aberrations, genomic abnormalities, gene expression alterations at mRNA or protein level and changes in DNA methylation status. In the present review we discuss the most important and well-studied CRC biomarkers, and their potential clinical significance and current approaches to molecular classification of colorectal tumors.
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.|National Medical Research Radiological Centre, Ministry of Healthcare of the Russian Federation, Moscow, Russia.
Anna V
AV
Kudryavtseva
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Anastasia V
AV
Lipatova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Andrew R
AR
Zaretsky
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Alexey A
AA
Moskalev
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.|National Medical Research Radiological Centre, Ministry of Healthcare of the Russian Federation, Moscow, Russia.
Maria S
MS
Fedorova
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Anastasiya S
AS
Rasskazova
National Medical Research Radiological Centre, Ministry of Healthcare of the Russian Federation, Moscow, Russia.
Galina A
GA
Shibukhova
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Anastasiya V
AV
Snezhkina
National Medical Research Radiological Centre, Ministry of Healthcare of the Russian Federation, Moscow, Russia.
Andrey D
AD
Kaprin
National Medical Research Radiological Centre, Ministry of Healthcare of the Russian Federation, Moscow, Russia.
Boris Y
BY
Alekseev
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Alexey A
AA
Dmitriev
Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia.|Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
George S
GS
Krasnov
D014408:Biomarkers, Tumor / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans
D014408:Biomarkers, Tumor; D005819:Genetic Markers
CpG island methylator phenotype; chromosomal instability; colorectal cancer; microsatellite instability; molecular markers