Immune responses to different patterns of exposure to ovalbumin in a mouse model of allergic rhinitis.
Allergic rhinitis (AR) has been a significant healthcare burden on individuals and society. However, the detailed effect of different patterns of allergen exposure on the development of AR remains controversial. A mouse model of AR was established to address the complex relationships between allergen exposure and the development of AR. Allergic symptom, OVA-specific IgE in serum and nasal lavage fluid, allergic inflammation in nasal tissues were evaluated after intranasal sensitization and challenge of ovalbumin (OVA) in mice treated with two different doses of allergen for different sensitized durations. Exposure to different doses and sensitized durations of OVA were capable of inducing allergic nasal response. Repetitive OVA exposure in the sensitization phase induced the recruitment of eosinophils and goblet cell hyperplasia. The level of OVA-specific IgE in serum depended on OVA exposure and was mediated in a duration-related manner. In addition, mice treated with low-dose OVA for prolonged duration manifested the major features of human local allergic rhinitis. There were dose- and duration-related effects of allergen exposure on the development of AR. LAR was associated with repetitive exposure to low-dose allergen. Thus, allergen avoidance should be an important aim of AR management.
Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, Guangdong, China.
Mei-Jun
MJ
Liang
Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, Guangdong, China.
Qing-Ling
QL
Fu
Department of Otorhinolaryngology, Hainan General Hospital, Haikou, China.
Hong-Yan
HY
Jiang
Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, Guangdong, China.
Feng-Hong
FH
Chen
Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, Guangdong, China.
Dong
D
Chen
Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, Guangdong, China.
De-Hua
DH
Chen
Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, Guangdong, China.
Zhi-Bin
ZB
Lin
Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, Guangdong, China. gzxur2708@163.com.
Rui
R
Xu
D000281:Administration, Intranasal; D000485:Allergens / Q000009:adverse effects / Q000276:immunology*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D007073:Immunoglobulin E / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009297:Nasal Mucosa / Q000276:immunology; D010047:Ovalbumin / Q000009:adverse effects / Q000276:immunology*; D011897:Random Allocation; D065631:Rhinitis, Allergic / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism
D000485:Allergens; D015415:Biomarkers; D007073:Immunoglobulin E; D010047:Ovalbumin
Allergen exposure; Allergic rhinitis; Dose; Duration; Local allergic rhinitis