A Facile Synthesis of (R)-3-Amino-4-phenylbutyric Acid from L-Aspartic Acid.
A practical synthesis of (R)-3-amino-4-phenylbutyric acid 1, based on Friedel-Crafts acylation with the α-aminocarboxyl group of L-aspartic acid retaining its original α-carbon chirality, is described.
a Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd ., 16-89, Kashima 3-chome, Yodogawa-ku, Osaka 532 , Japan.
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Seki
a Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd ., 16-89, Kashima 3-chome, Yodogawa-ku, Osaka 532 , Japan.
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Matsumoto
4-phenyl-3-aminobutyric acid; Friedel–Crafts acylation; α-aminoketone; β-amino acid; L-aspartic acid