Physiological vortices in the sinuses of Valsalva: An in vitro approach for bio-prosthetic valves.
The physiological flow dynamics within the Valsalva sinuses, in terms of global and local parameters, are still not fully understood. This study attempts to identify the physiological conditions as closely as possible, and to give an explanation of the different and sometime contradictory results in literature.



An in vitro approach was implemented for testing porcine bio-prosthetic valves operating within different aortic root configurations. All tests were performed on a pulse duplicator, under physiological pressure and flow conditions. The fluid dynamics established in the various cases were analysed by means of 2D Particle Image Velocimetry, and related with the achieved hydrodynamic performance.



Each configuration is associated with substantially different flow dynamics, which significantly affects the valve performance. The configuration most closely replicating healthy native anatomy was characterised by the best hemodynamic performance, and any mismatch in size and position between the valve and the root produced substantial modification of the fluid dynamics downstream of the valve, hindering the hydrodynamic performance of the system. The worst conditions were observed for a configuration characterised by the total absence of the Valsalva sinuses.



This study provides an explanation for the different vortical structures described in the literature downstream of bioprosthetic valves, enlightening the experimental complications in valve testing. Most importantly, the results clearly identify the fluid mechanisms promoted by the Valsalva sinuses to enhance the ejection and closing phases, and this study exposes the importance of an optimal integration of the valve and root, to operate as a single system.
UCL Cardiovascular Engineering Laboratory, UCL Mechanical Engineering, University College London, UK; Cardiovascular Fluid Dynamics Laboratory HER, Department of Civil, Environmental and Architectural Engineering - University of Padua, Italy.
Riccardo
R
Toninato
UCL Cardiovascular Engineering Laboratory, UCL Mechanical Engineering, University College London, UK.
Jacob
J
Salmon
Cardiovascular Fluid Dynamics Laboratory HER, Department of Civil, Environmental and Architectural Engineering - University of Padua, Italy.
Francesca Maria
FM
Susin
UCL Cardiovascular Engineering Laboratory, UCL Mechanical Engineering, University College London, UK.
Andrea
A
Ducci
UCL Cardiovascular Engineering Laboratory, UCL Mechanical Engineering, University College London, UK. Electronic address: g.burriesci@ucl.ac.uk.
Gaetano
G
Burriesci
D000818:Animals; D001021:Aortic Valve / Q000502:physiology; D001705:Bioprosthesis; D006350:Heart Valve Prosthesis; D006801:Humans; D057446:Hydrodynamics; D008955:Models, Cardiovascular; D011312:Pressure; D012212:Rheology; D012850:Sinus of Valsalva / Q000502:physiology*; D034421:Sus scrofa
Bioprosthetic valve; In vitro testing; PIV; Valsalva sinuses