Amniotic Fluid-Soluble Form of Triggering Receptors Expressed on Myeloid Cells: A Physiologic Constituent at Term.
BACKGROUND
Triggering receptors expressed on myeloid cells-1 (TREM-1) are innate immune receptors that mediate inflammatory response. In recent times, the role of these receptors has become the focus of several studies in the gestational context. Evaluation of soluble TREM-1 concentration in normal pregnancy is scarce, and no data are available on the levels of this receptor in the last weeks of normal pregnancy.


METHODS
Amniotic fluid (AF) samples were obtained from 77 patients in the last weeks of normal pregnancy during cesarean section, and the soluble form of TREM-1 (sTREM-1) levels determined using specific sandwich enzyme-linked immunosorbent assay kit.


RESULTS
sTREM-1 was detectable in all AF samples, and its levels did not vary in the last weeks of third trimester pregnancy. There was no correlation between sTREM-1 levels in AF and advancing gestational age.


CONCLUSIONS
sTREM-1 is a physiologic constituent of AF and its levels are not temporally regulated in pregnancies at term.
Department of Pathology, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, Brazil.
Natália
N
Prearo Moço
Laura
L
Fernandes Martin
Bruna
B
Ribeiro de Andrade Ramos
Rodrigo
R
Paupério Soares de Camargo
Stephanno
S
Gomes Pereira Sarmento
Karayna Gil
KG
Fernandes
Dionísio
D
Chiaratto Filho
Hélio
H
Amante Miot
Márcia
M
Guimarães da Silva
D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism*; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D055815:Young Adult
D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1