HPMC-based gastroretentive dual working matrices coated with Ca(+2) ion crosslinked alginate-fenugreek gum gel membrane.
Novel alginate-fenugreek gum (FG) gel membrane coated hydroxypropylmethylcellulose (HPMC) based matrix tablets were developed for intragastric quetiapine fumarate (QF) delivery by combining floating and swelling mechanisms. The effects of polymer blend ratios [HPMC K4M:HPMC E15] and citric acid contents on time taken for 50% drug release (t50%, min) and drug release at 8h (Q8h, %) were studied to optimize the core tablets by 3(2) factorial design. The optimized tablets (F-O) exhibited t50% of 247.67±3.51min and Q8h of 71.11±0.32% with minimum errors in prediction. The optimized tablets were coated with Ca(+2) ions crosslinked alginate-FG gel membrane by diffusion-controlled interfacial complexation technique. The biopolymeric-coated optimized matrices exhibited superior buoyancy, preferred swelling characteristics and slower drug release rate. The drug release profiles of the QF-loaded uncoated and coated optimized matrices were best fitted in Korsmeyer-Peppas model with anomalous diffusion driven mechanism. The uncoated and coated tablets containing QF were also characterized for drug-excipients compatibility, thermal behaviour and surface morphology by FTIR, DSC and SEM analyses, respectively. Thus, the newly developed alginate-FG gel membrane coated HPMC matrices are appropriate for intragastric delivery of QF over a prolonged period of time with greater therapeutic benefits.
Faculty of Pharmacy, AIMST University, Semeling, Kedah 08100, Malaysia; Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India. Electronic address: hriday.bera1@gmail.com.
Hriday
H
Bera
Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India.
Chakravarthy
C
Gaini
Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India.
Sanoj
S
Kumar
Formulation & Development, Dr Reddy's Lab. Ltd., Hyderabad 500090, India.
Srimanta
S
Sarkar
Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India.
Shashank
S
Boddupalli
Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India.
Sohitha Reddy
SR
Ippagunta
D005881:Gingiva / Q000737:chemistry*; D065347:Hypromellose Derivatives / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D008567:Membranes, Artificial; D000069348:Quetiapine Fumarate / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D013608:Tablets, Enteric-Coated; D029910:Trigonella / Q000737:chemistry*
D008567:Membranes, Artificial; D013608:Tablets, Enteric-Coated; D000069348:Quetiapine Fumarate; D065347:Hypromellose Derivatives
Alginate; Fenugreek gum; Floating; Gastroretentive drug delivery system; Hydroxypropylmethylcellulose; Quetiapine fumarate; Swelling