HIV-associated cystic lesions of the parotid gland.
We present two cases of an HIV-associated parotid gland cyst. One case was a 36-year-old HIV infected woman. She was diagnosed with HIV infection and presented with slowly enlarged parotid gland cysts together with elevation of HIV viral RNA copies/mL in her serum. She was performed parotid gland biopsy under the general anesthesia. The histopathologic analysis revealed negative HIV p24-antigen in her parotid gland tissue. The other case was a 43-year-old man found his parotid gland swelling shortly after highly active antiretroviral therapy (HAART). He was diagnosed with HIV infection 2 years previously. He had started HAART several days before. He showed exceeding elevation of IgE in his serum. We treated him with medication using anti-histamic drugs for his cyst. A computed tomography scan revealed a complete response of his parotid gland cyst 4 weeks after the medication. His serum IgE level was decreased to half of the level before the medication. These findings suggested that the parotid gland swelling associated with HIV was due to various factors including immune reconstitution inflammatory syndrome (IRIS). In case such a parotid gland swelling, we could avoid invasive treatments.
Department of Otorhinolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan; Department of Otorhinolaryngology, Obihiro Kousei Hospital, Japan. Electronic address: ogasawara.n@sapmed.ac.jp.
Noriko
N
Ogasawara
Department of Otorhinolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Ken-Ichi
KI
Takano
Department of Internal Medicine, Obihiro Kousei Hospital, Japan.
Hajime
H
Kobayashi
Department of Pathology, Obihiro Kousei Hospital, Japan.
Keisuke
K
Kikuchi
Department of Otorhinolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Hiroshi
H
Matsumiya
Department of Otorhinolaryngology, Obihiro Kousei Hospital, Japan.
Iwao
I
Yoshioka
Department of Otorhinolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Tetsuo
T
Himi
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D003560:Cysts / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D016655:HIV Core Protein p24 / Q000378:metabolism; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D010305:Parotid Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology*; D012367:RNA, Viral / Q000378:metabolism; D014057:Tomography, X-Ray Computed
D016655:HIV Core Protein p24; D006633:Histamine Antagonists; D012367:RNA, Viral; D007073:Immunoglobulin E
HIV-associated; Hyper-IgE syndrome; Immune reconstitution inflammatory syndrome; Parotid gland cyst