Dynamins and BAR Proteins-Safeguards against Cancer.
Dynamins and BAR proteins are crucial in a wide variety of cellular processes for their ability to mediate membrane remodeling, such as membrane curvature and membrane fission and fusion. In this review, we highlight dynamins and BAR proteins and the cellular mechanisms that are involved in the initiation and progression of cancer. We specifically discuss the roles of the seproteinsin endocytosis, endo-lysosomal trafficking, autophagy, and apoptosis as these processes are all tightly linked to membrane remodeling and cancer.
Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Anna C
AC
Sundborger
Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Jenny E
JE
Hinshaw
D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D034281:Dynamins / Q000378:metabolism*; D004705:Endocytosis; D005260:Female; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000378:metabolism* / Q000503:physiopathology
D020558:GTP Phosphohydrolases; D034281:Dynamins