Systemic lupus erythematosus and small vessel coronary infarction: who's to blame?
Systemic lupus erythematosus (SLE) with or without accompanying antiphospholipid antibody syndrome (APLS) is known to cause myocardial ischemia via multiple mechanisms, including accelerated coronary atherosclerosis, impaired coronary vasomotor function, spontaneous intracoronary thrombus formation, or endothelial dysfunction in the context of cardiac syndrome X (CSX). We present the case of a young woman with SLE and APLS who presented with myocardial ischemia and peculiar echocardiographic evidence of multiple small septal perforator infarcts despite a normal coronary angiogram, a rare combination.
Mackay Base Hospital, James Cook University School of Medicine, 475 Bridge Road, Mackay, Queensland, 4740, Australia.
Sameer
S
Tatavarty
Mackay Base Hospital, James Cook University School of Medicine, 475 Bridge Road, Mackay, Queensland, 4740, Australia. stefanbuchholz@hotmail.com.
Stefan
S
Buchholz
Antiphospholipid antibody syndrome; Myocardial infarction; Normal coronary angiogram; Systemic lupus erythematosus