Relationship between Intrauterine Bacterial Infection and Early Embryonic Developmental Arrest.
BACKGROUND
Early embryonic developmental arrest is the most commonly understudied adverse outcome of pregnancy. The relevance of intrauterine infection to spontaneous embryonic death is rarely studied and remains unclear. This study aimed to investigate the relationship between intrauterine bacterial infection and early embryonic developmental arrest.


METHODS
Embryonic chorion tissue and uterine swabs for bacterial detection were obtained from 33 patients who underwent artificial abortion (control group) and from 45 patients who displayed early embryonic developmental arrest (trial group).


RESULTS
Intrauterine bacterial infection was discovered in both groups. The infection rate was 24.44% (11/45) in the early embryonic developmental arrest group and 9.09% (3/33) in the artificial abortion group. Classification analysis revealed that the highest detection rate for Micrococcus luteus in the early embryonic developmental arrest group was 13.33% (6/45), and none was detected in the artificial abortion group. M. luteus infection was significantly different between the groups (P < 0.05 as shown by Fisher's exact test). In addition, no correlation was found between intrauterine bacterial infection and history of early embryonic developmental arrest.


CONCLUSIONS
M. luteus infection is related to early embryonic developmental arrest and might be one of its causative factors.
Laboratory of Microbiology, Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
Shao-Fei
SF
Yan
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
Xin-Yan
XY
Liu
Department of Family Planning, Tianjin Central Hospital of Gynecology and Obstetrics, Tianjin 300052, China.
Yun-Fei
YF
Cheng
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhi-Yi
ZY
Li
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
Jie
J
Ou
Laboratory of Microbiology, Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
Wei
W
Wang
Laboratory of Microbiology, Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
Feng-Qin
FQ
Li
D000028:Abortion, Induced / Q000706:statistics & numerical data; D000022:Abortion, Spontaneous / Q000209:etiology* / Q000382:microbiology*; D001424:Bacterial Infections / Q000150:complications*; D005260:Female; D006801:Humans; D016982:Micrococcus luteus / Q000472:pathogenicity; D011247:Pregnancy; D014599:Uterus / Q000382:microbiology