Prognostic significance of microRNA-200c in various types of cancer: An updated meta-analysis of 34 studies.
Previous studies have indicated that miR-200c is a promising cancer biomarker. However, different studies have presented conflicting results. Therefore, the aim of the present study was to perform a meta-analysis of miR-200c based on 34 relevant studies. The Materials and methods sections of papers were carefully identified using the databases PubMed, Web of Science and Embase for publications up to December 4, 2015. Pooled hazard ratios (HRs) and 95% confidence intervals (95% CIs) were systematically calculated to investigate the association between the expression of miR-200c and cancer prognosis. The results demonstrated that elevated expression levels of miR-200c indicated significantly worse overall survival rates (HR=1.37, 95% CI: 1.01, 1.85), and a high level of miR-200c was considered an indicator of an unfavorable prognosis in patients from Europe and America (HR=1.85, 95% CI: 1.27, 2.69). Furthermore, overexpression of miR-200c was significantly associated with progression of the disease in the subgroups of tissue and blood samples (HR=0.68 and 2.45, respectively), and inferior overall survival rates for the blood subgroup were revealed (HR=2.21, 95% CI: 1.04, 4.72). In addition, miR-200c was of prognostic value in several disease subgroups. Taken together, high expression levels of miR-200c are of significant prognostic value in various human malignancies.
Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, P.R. China.
Jia-Yi
JY
Zhang
Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, P.R. China.
Ya-Min
YM
Wang
The First Clinical Medical College of Nanjing Medical University, Nanjing 210029, P.R. China.
LE-Bin
LB
Song
Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, P.R. China.
Chen
C
Chen
Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, P.R. China.
Yi-Chun
YC
Wang
Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, P.R. China.
Ning-Hong
NH
Song
cancer; hazard ratio; meta-analysis; miR-200c; prognosis