Outcome of operable oral cavity cancer and impact of maintenance metronomic chemotherapy: A retrospective study from rural India.
BACKGROUND
Oral cavity cancer is the most common cancer among rural India. There is a paucity of data for outcomes of operable oral cavity cancer from rural India. Use of maintenance metronomic may delay or avoid relapse.


OBJECTIVE
To evaluate outcomes of operable oral cavity carcinoma and evaluate impact of maintenance metronomic chemotherapy.


OBJECTIVE
To evaluate disease-free survival (DFS), overall survival (OS), and factors affecting the outcome in operable oral cavity cancer.


METHODS
Data of patients diagnosed with oral cavity cancer registered between May 2008 and May 2014 were retrieved. Only those patients with operable oral cavity cancer and upfront definitive surgery were included in the study. Demographic profile, stage, tobacco consumption, adjuvant therapy, and pattern of failure were collected. Kaplan-Meir survival analysis was used to determine DFS and OS. Log-rank test was used to evaluate factors affecting outcome.


RESULTS
Median follow-up is 24 months. Out of 335 patients, 225 (67%) had advanced operable cancer with 42/225 (18%) and 183/225 (82%) as Stages III and IVA, respectively. Buccal mucosa was the most common subsite (178/335, 53%) followed by tongue (63/335, 19%). Ninety-two percent patients were addicted to smokeless tobacco, whereas 27% were smokers. Median DFS is 13 months with 2 years relative DFS 32%. Median OS is 30 months, with 2 years OS of 54%. Metronomic adjuvant oral chemotherapy was given in 130/225 (58%); Stage III and IVA patients with median of 14 months (3-18 months). Use of metronomic chemotherapy improved DFS (8 vs. 14 months, P = 0.22) and OS (14 vs. 26 months, P = 0.04).


CONCLUSIONS
Oral cavity cancer is a major health care problem in rural India. Presentation at advanced stage leads to suboptimal outcomes. Benefit of metronomic maintenance chemotherapy in locally advanced oral cavity needs to be further evaluated prospectively.
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India; Department of Medical Oncology, BKLWH, Ratnagiri, Maharashtra, India; Department of Radiation Oncology, BKLWH, Ratnagiri, Maharashtra, India.
Avinash
A
Pandey
Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
A
A
Desai
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
V
V
Ostwal
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
V
V
Patil
Department of Radiation Oncology, BKLWH, Ratnagiri, Maharashtra, India.
A
A
Kulkarni
Department of Pathology, BKLWH, Ratnagiri, Maharashtra, India.
R
R
Kulkarni
Department of Radiodiagnosis, BKLWH, Ratnagiri, Maharashtra, India.
N
N
Patil
Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
D
D
Chaukar
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
K
K
Prabhash
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
Shripad D
SD
Banavali
Locally advanced head and neck squamous cell carcinoma; maintenance metronomic; oral cavity