Association of three single nucleotide polymorphisms at the SIX1-SIX6 locus with primary open angle glaucoma in the Chinese population.
This study investigated the genetic association of three single nucleotide polymorphisms (SNPs; rs10483727, rs33912345, and rs146737847) at the SIX1-SIX6 locus with primary open angle glaucoma (POAG) in the Chinese population. A total of 866 subjects with POAG (685 high-tension glaucoma (HTG) and 181 normal-tension glaucoma (NTG)) and 266 control individuals were included. Significant genetic association was identified for rs10483727 in HTG (P=0.02; odds ratio (OR)=1.31), NTG (P=7.41×10(-6); OR=2.71), and POAG (i.e., HTG and NTG combined; P=0.001; OR=1.44). rs33912345 was also significantly associated with HTG (P=0.008; OR=1.36), NTG(P=2.72×10(-6); OR=2.27), and POAG (P=3.84×10(-4); OR=1.49). The rare SIX6 mutation, rs146737847, was not found in the subjects enrolled in this study. Stratification by patient age identified that both rs10483727 and rs33912345 were significantly associated with NTG in patients aged above 40 years (P=2.08×10(-5); OR=2.28), whereas in patients aged between 20-40 years, rs33912345 was significantly associated with NTG (P=0.017; OR=2.06). In HTG, the genetic associations for both rs10483727 and rs33912345 were significant in patients aged between 20-40 years (P=0.006; OR=1.56) but not in those aged above 40 years (P=0.118, OR=1.21 and P=0.042, OR=1.29, respectively). This study replicated the association of POAG with two SNPs at the SIX1-SIX6 locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG in patients aged above 40 years.
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.|Beijing Ophthalmology & Visual Science Key Laboratory, Capital Medical University, Beijing, 100730, China.
Jinghong
J
Sang
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.|Beijing Ophthalmology & Visual Science Key Laboratory, Capital Medical University, Beijing, 100730, China.
Liyun
L
Jia
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.|Beijing Ophthalmology & Visual Science Key Laboratory, Capital Medical University, Beijing, 100730, China.
Bowen
B
Zhao
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.|Beijing Ophthalmology & Visual Science Key Laboratory, Capital Medical University, Beijing, 100730, China.
Huaizhou
H
Wang
The First Affiliated Hospital of Nanyang Medical College, Nanyang, 473000, China.
Nihong
N
Zhang
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. wningli@vip.163.com.|Beijing Ophthalmology & Visual Science Key Laboratory, Capital Medical University, Beijing, 100730, China. wningli@vip.163.com.|Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. wningli@vip.163.com.
Ningli
N
Wang
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005838:Genotype; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D015534:Trans-Activators / Q000235:genetics*
D018398:Homeodomain Proteins; C099236:SIX1 protein, human; C491945:SIX6 protein, human; D015534:Trans-Activators
Chinese population; SIX1-SIX6; primary open angle glaucoma