Use of an attenuated live Salmonella Typhimurium vaccine on three breeding pig units: A longitudinal observational field study.
The study examined the effects of a licensed live Salmonella Typhimurium vaccine, administered to sows and gilts on three commercial pig units experiencing clinical salmonellosis associated with S. Typhimurium or its monophasic variant. After vaccination, clinical salmonellosis resolved and shedding of S. Typhimurium declined markedly and persistently on all breeding or breeding-finishing units, during the one- to two-year monitoring period. On two finishing units supplied in part by one of the vaccinated herds, pigs from the vaccinated herd were less likely to shed Salmonella than those from non-vaccinating herds, and Salmonella counts in faeces were also lower from the vaccine-linked animals. Non-Typhimurium Salmonella serovars were isolated typically in fewer than 10% of samples, and showed no clear temporal changes in frequency. Vaccination of dams alone with S. Typhimurium was associated with reduced shedding of closely-related serovars among all age groups in this commercial setting.
Department of Bacteriology and Food Safety, Animal and Plant Health Agency (APHA-Weybridge), Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK.
R
R
Davies
Department of Bacteriology and Food Safety, Animal and Plant Health Agency (APHA-Weybridge), Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK.
R J
RJ
Gosling
Department of Bacteriology and Food Safety, Animal and Plant Health Agency (APHA-Weybridge), Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK. Electronic address: research@andy.wales.
A D
AD
Wales
Department of Epidemiological Sciences, Animal and Plant Health Agency (APHA-Weybridge), Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK.
R P
RP
Smith
D000818:Animals; D057138:Bacterial Shedding; D001947:Breeding; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000382:microbiology; D005260:Female; D008137:Longitudinal Studies; D012481:Salmonella Infections, Animal / Q000382:microbiology / Q000517:prevention & control*; D022562:Salmonella Vaccines / Q000008:administration & dosage*; D012486:Salmonella typhimurium / Q000276:immunology* / Q000302:isolation & purification / Q000502:physiology; D065288:Serogroup; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology / Q000517:prevention & control*; D014611:Vaccination / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000008:administration & dosage
D022562:Salmonella Vaccines; D014613:Vaccines, Attenuated
Pig; Salmonella; Swine; Typhimurium; Vaccine