Therapeutic Interventions of Tissue Specific Autoimmune Onset in Systemic Lupus Erythematosus.
BACKGROUND
Systemic lupus erythematosus (lupus) is a female predominant autoimmune disease. The autoreactive B cells and T helper cells together are known to develop adverse immune responses in different tissues like kidney, bone, cardiovascular and central nervous system. Progression of disease is associated with deposition of immune complex which initiates tissue damage. The therapy for lupus still includes corticosteroids to reduce allergic manifestations and inflammatory immune responses. Recent observations suggested that, mycophenolate mofetil and cyclophosphamide treatment in combination with corticosteroids have benefit in lupus therapy.


METHODS
The prospect of B cell depletion by CD20 targeted monoclonal antibody Rituximab has been demonstrated in lupus patients. The CD52 specific monoclonal antibody Alemtuzumab is another proposition for lupus therapy. The drug Belimumab inhibits B cell activation by altering BAFF/APRIL signal cascade. Recent discovery of the CD22 targeted Epratuzumab also shows therapeutic prospect. The researches on new generation drugs for autoimmune lupus include search for inhibitors of CD40- CD40Ligand interactions, CD86 activation, selective modulation of complement cascades. The choice of inhibitors of transcription factor NF-κBp65 and selective modulators for estrogen receptor alpha are proposed areas of lupus drug discovery research.


CONCLUSIONS
Keeping a close eye on the mechanisms of disease onset, a comprehensive view is provided on recent therapy of systemic lupus erythematosus.
Microbiology, Immunology and Biochemistry, Albert Lake Drive, The Quarter, A-I-2640, P.O. Box 318; Anguilla. United Kingdom.
Subhajit
S
Dasgupta
Academic Magnet High School, Charleston, South Carolina. United States.
Shaoni
S
Dasgupta
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use*; D055808:Drug Discovery; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000276:immunology; D009173:Mycophenolic Acid / Q000627:therapeutic use*
D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide; D009173:Mycophenolic Acid
Autoimmune disease; B cell; ER-alpha; Lupus; NF-kappa-B.; monoclonal antibody