Antioxidative Activities of Both Oleic Acid and Camellia tenuifolia Seed Oil Are Regulated by the Transcription Factor DAF-16/FOXO in Caenorhabditis elegans.
BACKGROUND
Tea seed oil is a high quality edible oil, yet lacking sufficient scientific evidences to support the nutritional and medical purposes. We identified major and minor components in Camellia tenuifolia seed oil and investigated the antioxidative activity and its underlying mechanisms in Caenorhabditis elegans.


RESULTS
The results showed that the major constitutes in C. tenuifolia seed oil were unsaturated fatty acids (~78.4%). Moreover, two minor compounds, β-amyrin and β-sitosterol, were identified and their antioxidative activity was examined. We found that oleic acid was the major constitute in C. tenuifolia seed oil and plays a key role in the antioxidative activity of C. tenuifolia seed oil in C. elegans.


CONCLUSIONS
This study found evidences that the transcription factor DAF-16/FOXO was involved in both oleic acid- and C. tenuifolia seed oil-mediated oxidative stress resistance in C. elegans. This study suggests the potential of C. tenuifolia seed oil as nutrient or functional foods.
Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan.
Chia-Cheng
CC
Wei
Department of Forestry and Resource Conservation, National Taiwan University, Taipei, Taiwan.
Pei-Ling
PL
Yen
Department of Forestry and Resource Conservation, National Taiwan University, Taipei, Taiwan.
Shang-Tzen
ST
Chang
Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.
Pei-Ling
PL
Cheng
Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.
Yi-Chen
YC
Lo
Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan.
Vivian Hsiu-Chuan
VH
Liao
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D028244:Camellia / Q000737:chemistry*; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D019301:Oleic Acid / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*
D000975:Antioxidants; D029742:Caenorhabditis elegans Proteins; D051858:Forkhead Transcription Factors; D010938:Plant Oils; C108831:daf-16 protein, C elegans; D019301:Oleic Acid