Expression of the Insulin-like Growth Factor-1 Receptor in Odontogenic Myxoma.
Odontogenic myxoma (OM) is a rare mesenchymal tumour arising in the jaws. The origin and pathogenesis of OM is poorly understood. The aim of this study was to characterize OM by immunolocalization of certain antigens in the tumour that are relevant for cellular differentiation, migration and maintenance.


METHODS
Five OMs were immunohistochemically investigated for expression of nestin, CD133, podoplanin, and insulin-like growth factor 1 receptor (IGF-1R).


RESULTS
OM failed to react with antibodies applied in this study, with the exception of IGF-1R in tumour cells.


CONCLUSIONS
OM is a poorly characterized benign, invasive tumour of the jaws. The absence of stem cell marker in OM does not exclude possible temporary expression of these antigens during certain phases of tumour development. The identification of IGF-1R in OM is shared with numerous tumours and indicates the ability of these tumour cells to respond to growth factors.
Department of Oral and Craniomaxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany rfriedrich@uke.de.
Reinhard E
RE
Friedrich
Institute of Neuropathology, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.
Christian
C
Hagel
Royal National Orthopaedic Hospital NHS Trust - Histopathology, Bone Tumours and Metabolic Bone Diseases, London, U.K.
Jozef
J
Zustin
D000071916:AC133 Antigen / Q000032:analysis; D006801:Humans; D009232:Myxoma / Q000737:chemistry*; D064231:Nestin / Q000032:analysis; D009808:Odontogenic Tumors / Q000737:chemistry*; D017526:Receptor, IGF Type 1 / Q000032:analysis*
D000071916:AC133 Antigen; D064231:Nestin; C000606023:PROM1 protein, human; D017526:Receptor, IGF Type 1
IGF-1R; Odontogenic myxoma; immunohistochemistry; odontogenic tumour; rare tumours