Effect of cigarette smoke on counts of immunoreactive cells to eotaxin-1 and eosinophils on the nasal mucosa in young patients with perennial allergic rhinitis.
BACKGROUND
In teenagers with perennial allergic rhinitis, exposure to tobacco cigarette smoke increases the count of eosinophils in the nasal mucosa; the recruitment of eosinophils arises from the combined action of a number of cellular and molecular signals, including eotaxin.


OBJECTIVE
To assess the effect of exposure to tobacco cigarette smoke on the count of immunoreactive cells to eotaxin-1 and eosinophils on the nasal mucosa of children and teenagers with perennial allergic rhinitis.


METHODS
In a cross-sectional study, forty-four patients were evaluated (aged 7-19 years old): 22 with and 22 with no exposure to tobacco cigarette smoke. After replying to 2 validated questionnaires, on Asthma and Allergies in Childhood and on the severity of nasal symptoms, nasal mucosal samples were obtained by scraping the middle one-third of the inferior turbinates. Then counts of immunoreactive cells to eotaxin-1 and eosinophils were assessed by immunohistochemistry.


RESULTS
Patients with exposure to tobacco cigarette smoke showed higher cell counts of both eotaxin-1 and eosinophils than patients with no exposure to the smoke, with no correlation between the two variables. However, both counts, of eotaxin-1 and eosinophils, were related to the cotinine/creatinine ratio.


CONCLUSIONS
Exposure to tobacco cigarette smoke can increase eotaxin-1 and the count of eosinophils in the nasal mucosa of young patients with perennial allergic rhinitis.
Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Service of Otorhinolaryngology, Mexico City, Mexico.
Bertha Beatriz
BB
Montaño-Velázquez
Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Service of Otorhinolaryngology, Mexico City, Mexico.
Eulalia Beatriz
EB
Flores-Rojas
Instituto Nacional de Pediatría, Molecular Pathology Laboratory, Department of Pathology Anatomy, Mexico City, Mexico.
Francisco Javier
FJ
García-Vázquez
Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Service of Otorhinolaryngology, Mexico City, Mexico.
Silvio
S
Jurado-Hernandez
Instituto Mexicano del Seguro Social, CMN La Raza, Hospital de Especialidades, Service of Immunology and Allergy, Mexico City, Mexico.
Marco Antonio
MA
Venancio Hernández
Instituto Mexicano del Seguro Social, CMN La Raza, Hospital de Especialidades, Service of Immunology and Allergy, Mexico City, Mexico.
Angélica Kathya
AK
Alanis Flores
Instituto Mexicano del Seguro Social, Centro Médico Nacional sXXI, P.B. Edificio C Salud en el Trabajo, Medical Research Unit in Otoneurology, Mexico City, Mexico. Electronic address: kathrine.jauregui@imss.gob.mx.
Kathrine
K
Jáuregui-Renaud
D000293:Adolescent; D000328:Adult; D002452:Cell Count; D054413:Chemokine CCL11 / Q000032:analysis / Q000276:immunology*; D002648:Child; D003430:Cross-Sectional Studies; D004804:Eosinophils / Q000166:cytology / Q000276:immunology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009297:Nasal Mucosa / Q000737:chemistry / Q000166:cytology / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology* / Q000473:pathology; D012720:Severity of Illness Index; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D055815:Young Adult
D054413:Chemokine CCL11; D014028:Tobacco Smoke Pollution
Allergic; Alérgico; Chemokine CCL11; Eosinophils; Eosinófilos; Quimiocina CCL11; Rhinitis; Rinite; Tabaco; Tobacco