BDNF DNA methylation changes as a biomarker of psychiatric disorders: literature review and open access database analysis.
Brain-derived neurotrophic factor (BDNF) plays an important role in nervous system development and function and it is well established that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders. Recently, numerous studies have associated the DNA methylation level of BDNF promoters with certain psychiatric phenotypes. In this review, we summarize data from current literature as well as from our own analysis with respect to the correlation of BDNF methylation changes with psychiatric disorders and address questions about whether DNA methylation related to the BDNF can be useful as biomarker for specific neuropsychiatric disorders.
Department of Neuroscience, Uppsala University, Husargatan 3, BMC, 75124, Uppsala, Sweden. galina.zheleznyakova@ki.se.|Department of Clinical Neuroscience, Karolinska Institute, Karolinska University Hospital, CMM L8:04, 17176, Stockholm, Sweden. galina.zheleznyakova@ki.se.
Galina Y
GY
Zheleznyakova
Department of Neuroscience, Uppsala University, Husargatan 3, BMC, 75124, Uppsala, Sweden.
Hao
H
Cao
Department of Neuroscience, Uppsala University, Husargatan 3, BMC, 75124, Uppsala, Sweden.
Helgi B
HB
Schiöth
D000818:Animals; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics* / Q000378:metabolism; D019175:DNA Methylation; D030541:Databases, Genetic; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D010641:Phenotype; D011401:Promoter Regions, Genetic
D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
BDNF; Biomarkers; DNA methylation; Psychiatric disorders