Influence of demographic and tumour variables on prostate cancer treatment with curative intent in Spain. Results of the 2010 national prostate cancer registry.
OBJECTIVE
The aim of this study is to determine which cancer and demographic criteria influence the indication for surgery (radical prostatectomy) or radiation therapy (external or brachytherapy) in the treatment of prostate cancer.


METHODS
An analysis of the 2714 patients of the 2010 National Prostate Cancer Registry treated with curative intent. The analysed variables were age, prostate-specific antigen (PSA), prostate volume, the number of biopsy cores, the percentage of positive cores, the stage, Gleason score, the type of pathologist, the presence of perineural invasion and the study centre. We analysed the association among these variables and the type of treatment (surgery vs. radiation therapy/brachytherapy), using a univariate analysis (Student's t test and chi-squared) and a binary multiple logistic regression.


RESULTS
The 48.12% of the patients (1306/2714) were treated with surgery, and 51.88% (1,408/2,714) underwent radiation therapy/brachytherapy. Differences were observed between the patients treated with prostatectomy and those treated with radiation therapy/brachytherapy (p<.05) in age (63.50±6.5 vs. 69.0±6.7), PSA (8.76±16.97 vs. 13.21±15.88), biopsied cores, percentage of positives cores (30.0±22 vs. 38.7±29), Gleason score (G6: 53.9% vs. 46.1%; G7: 45% vs. 55% G8-10: 26.6%, 73.4%), stage (localised: 50% vs. 50%; locally advanced: 14.6% vs. 85.4%), perineural invasion and hospital centre. In the multivariate analysis, the selected independent variables were age, PSA, percentage of positives cores, stage, Gleason score and hospital centre.


CONCLUSIONS
According to our study, age, tumour aggressiveness and stage and the centre where the patient will be treated affect the selection of curative treatment for prostate cancer.
Servicio de Urología, Hospital Clínico Universitario, Valencia, España. Electronic address: marjabaloyas@gmail.com.
J M
JM
Martínez-Jabaloyas
Servicio de Urología, Hospital Clínico Universitario, Valencia, España.
A
A
Castelló-Porcar
Servicio de Urología, Hospital Virgen de la Macarena, Sevilla, España.
A C
AC
González-Baena
Servicio de Urología, Hospital Virgen de las Nieves, Granada, España.
J M
JM
Cózar-Olmo
Servicio de Urología, Hospital Morales Meseguer, Murcia, España.
B
B
Miñana-López
Servicio de Urología, C.H.U.A.C., Hospital Universitario de Salamanca, Salamanca, España.
F
F
Gómez-Veiga
Servicio de Urología, Hospital Gregorio Marañón, Madrid, España.
A
A
Rodriguez-Antolín
D000368:Aged; D001918:Brachytherapy; D003710:Demography; D006801:Humans; D008297:Male; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D012042:Registries; D013030:Spain
Brachytherapy; Braquiterapia; Cirugía; Cáncer de próstata; Prostate cancer; Prostatectomía radical; Radiation therapy; Radical prostatectomy; Radioterapia; Surgery; Tratamiento; Treatment