Gastrointestinal bleeding secondary to trimethoprim-sulfamethoxazole-induced vitamin K deficiency.
There is a well-known association between vitamin K deficiency and haemorrhagic events including gastrointestinal bleeding. There is also a well-known association between both poor dietary intake of vitamin K and chronic antibiotic use and the development of vitamin K deficiency. Although the medical literature notes that cephalosporin antibiotics have a propensity to cause vitamin K deficiency due to the molecular structure of the medications and their ability to suppress the synthesis of clotting factors, there are other antibiotics that have also been implicated in the development of vitamin K deficiency. There are very few reports of trimethoprim/sulfamethoxazole causing vitamin K deficiency and further leading to bleeding episodes. We present such a case and discuss the risk factors leading to such complications.
Department of Internal Medicine, University of Arizona Medical Center-University Campus, Tucson, Arizona, USA.
Azadeh
A
Fotouhie
Department of Internal Medicine, University of Arizona Medical Center-University Campus, Tucson, Arizona, USA.
Hem
H
Desai
Department of Internal Medicine, University of Arizona Medical Center-University Campus, Tucson, Arizona, USA.
Nour Alhoda
NA
Parsa
Department of Internal Medicine, University of Arizona Medical Center-University Campus, Tucson, Arizona, USA.
Skye
S
King
D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000627:therapeutic use; D014813:Vitamin K Deficiency / Q000139:chemically induced* / Q000175:diagnosis; D006475:Vitamin K Deficiency Bleeding / Q000175:diagnosis*
D015662:Trimethoprim, Sulfamethoxazole Drug Combination