Infectious Angiogenesis-Different Pathways, the Same Goal.
Infectious angiogenesis is the biological response of neoangiogenesis induced by infectious organisms. The authors present 3 exemplary entities which show paradigmatic clinico-pathological settings of infectious angiogenesis: Bacillary angiomatosis, Orf (ecthyma contagiosum), and Kaposi sarcoma. The authors review the literature and elucidate etiopathogenetic pathways leading to the phenomenon of neovascularization stimulated by infectious organisms. The authors describe the clinical and histological pictures, interactions between microorganisms and host cells, and changes that occur within cellular structures, as well as angiogenic factors that underpin infectious angiogenesis. The importance of chronic inflammation and tumor angiogenesis is emphasized.
*Resident, Department of Pathology, Hospital 12 de Octubre, Madrid, Spain; †Dermatologist, Dermatopathologie Friedrichshafen, Friedrichshafen, Germany; ‡Dermatologist, Department of Pathology, Medical School, Universidad Complutense, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain; and §Pathologist, Department of Pathology, Medical School, Universidad Complutense, Instituto i+12, Hospital Universitario 12 de Octubre, Madrid, Spain.
Maria
M
Urbanowicz
Heinz
H
Kutzner
Erica
E
Riveiro-Falkenbach
Jose L
JL
Rodriguez-Peralto
D000328:Adult; D016917:Angiomatosis, Bacillary / Q000382:microbiology / Q000473:pathology* / Q000628:therapy; D018416:Bartonella henselae / Q000235:genetics; D001706:Biopsy; D001808:Blood Vessels / Q000473:pathology*; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D003937:Diagnosis, Differential; D004474:Ecthyma, Contagious / Q000473:pathology* / Q000628:therapy / Q000821:virology; D019288:Herpesvirus 8, Human / Q000235:genetics; D054884:Host-Pathogen Interactions; D006801:Humans; D008297:Male; D009389:Neovascularization, Pathologic; D009923:Orf virus / Q000235:genetics; D011237:Predictive Value of Tests; D011379:Prognosis; D012514:Sarcoma, Kaposi / Q000098:blood supply* / Q000473:pathology / Q000628:therapy / Q000821:virology; D012867:Skin / Q000098:blood supply*; D012878:Skin Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000628:therapy / Q000821:virology
D004269:DNA, Bacterial; D004279:DNA, Viral