Parenteral nutrition in short bowel syndrome patients, regardless of its duration, increases serum proinflammatory cytokines.
Short bowel syndrome is a severe malabsorption disorder, and prolonged parenteral nutrition is essential for survival in some cases. Among the undesirable effects of long-term parenteral nutrition is an increase in proinflammatory cytokines. The aim of the present study was to measure the serum levels of interleukin-6, interleukin-10, tumor necrosis factor alpha, and transforming growth factor beta, in patients with short bowel syndrome on cyclic parenteral nutrition and patients who had previously received but no longer require parenteral nutrition. The study was cross-sectional and observational. Three groups were studied as follows: Parenteral nutrition group, 9 patients with short bowel syndrome that receive cyclic parenteral nutrition; Oral nutrition group, 10 patients with the same syndrome who had been weaned off parenteral nutrition for at least 1 year prior to the study; Control group, 13 healthy adults, matched for age and sex to parenteral and oral groups. The following data were collected: age, tobacco use, drug therapies, dietary intake, body weight, height, blood collection. All interleukins were significantly higher in the parenteral group compared with the control group as follows: interleukin-6: 22 ± 19 vs 1.5 ± 1.4 pg/mL, P= .0002; transforming growth factor β: 854 ± 204 vs 607 ± 280 pg/mL, P= .04; interleukin-10: 8 ± 37 vs 0.6 ± 4, P= .03; tumor necrosis factor α: 20 ± 8 vs 8 ± 4 pg/mL, P< .0001. We concluded that parenteral nutrition in short bowel syndrome patients, regardless of its duration, increases serum proinflammatory cytokines.
Food Service City Hall Campus of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: leticia.bizari@usp.br.
Letícia
L
Bizari
Department of Internal Medicine, Ribeirao Preto Medical School/University of Sao Paulo (USP), Sao Paulo, Brazil. Electronic address: andressa_feijo@yahoo.com.br.
Andressa Feijó
AF
da Silva Santos
Department of Internal Medicine, Ribeirao Preto Medical School/University of Sao Paulo (USP), Sao Paulo, Brazil. Electronic address: ntfoss@fmrp.usp.br.
Norma Tiraboschi
NT
Foss
Department of Internal Medicine, Ribeirao Preto Medical School/University of Sao Paulo (USP), Sao Paulo, Brazil. Electronic address: jsmarchi@fmrp.usp.br.
Júlio Sérgio
JS
Marchini
Department of Internal Medicine, Ribeirao Preto Medical School/University of Sao Paulo (USP), Sao Paulo, Brazil. Electronic address: vmmsuen@fmrp.usp.br.
Vivian Marques Miguel
VM
Suen
D000368:Aged; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D012778:Short Bowel Syndrome / Q000097:blood* / Q000628:therapy*; D011795:Surveys and Questionnaires
D016207:Cytokines
Cytokines; Inflammation; Intestinal malabsorption; Parenteral nutrition; Short bowel syndrome