Evaluation of Postmortem Cerebrospinal Fluid S100B Protein and Serotonin Levels: Comparison of Suicidal Versus Nonsuicidal Deaths in Konya, Turkey.
Although suicide is a preventable public health problem, objective assays for suicide risk are limited. In this study, it was aimed to determine levels of S100B protein and serotonin as a marker for risk of suicide. S100B protein and serotonin levels were investigated with ELISA method in the cerebrospinal fluid (CSF) in medicolegal autopsy cases, including those of suicide cases (n = 32) and nonsuicide cases (n = 56). The CSF S100B levels were higher (9.3 ± 2.9 ng/mL vs. 5.4 ± 2.0 ng/mL), and serotonin levels were lower (10.4 ± 4.9 ng/mL vs. 19.0 ± 5.7 ng/mL) in suicide group than nonsuicide group (p < 0.05). There was no correlation between S100B protein and serotonin levels with gender, age groups, postmortem interval, and cause of death. It is concluded that both S100B protein and serotonin in CSF may be useful for determination of suicide risk.
Department of Forensic Medicine, Faculty of Medicine, Selcuk University, 42075, Konya, Turkey. drhakan2000@gmail.com.
Kamil Hakan
0000-0002-7685-266X
KH
Dogan
Department of Biochemistry, Private Ticaret Borsasi Hospital, Sukran Mh. Taskapu Medrese Sk., 42040, Konya, Turkey.
Mustafa
M
Unaldi
Department of Forensic Medicine, Meram Medical School, Necmettin Erbakan University, Akyokus, 42080, Konya, Turkey.
Serafettin
S
Demirci
D001344:Autopsy; D015415:Biomarkers; D006801:Humans; D064568:S100 Calcium Binding Protein beta Subunit / Q000134:cerebrospinal fluid*; D012701:Serotonin / Q000134:cerebrospinal fluid*; D013405:Suicide; D014421:Turkey
D015415:Biomarkers; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D012701:Serotonin
S100B; death; forensic science; postmortem; serotonin; suicide