Small RNAs Play Big Roles: MicroRNAs in Diabetic Wound Healing.
Skin and corneal wounds in diabetics are a major healthcare burden. MicroRNAs are small, non-coding RNAs that post-transcriptionally regulate the expression of protein-coding genes. Studies have identified microRNAs involved in all phases of wound healing. The dysregulation of microRNAs can contribute to impaired or delayed skin and corneal wound healing in diabetics. Here, we present a comprehensive review of the literature involving microRNAs in diabetic skin and corneal wound healing as well as those serving as potential biomarkers for diabetic wound healing.
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Henry Ford Immunology Program, Department of Dermatology and Department of Internal Medicine, Henry Ford Hospital, 1 Ford Place, Detroit, MI, USA. qmi1@hfhs.org.
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