Retinal Ganglion Cell Atrophy in Homonymous Hemianopia due to Acquired Occipital Lesions Observed Using Cirrus High-Definition-OCT.
Purpose. To report a reduction in macular ganglion cell layer and inner plexiform layer (GCL+IPL) thickness and circumpapillary retinal nerve fiber layer (cpRNFL) thickness using spectral-domain optical coherence tomography in patients with homonymous hemianopia due to posterior cerebral artery (PCA) stroke. Methods. Seven patients with PCA stroke were examined using Cirrus high-definition-OCT. The GCL+IPL thicknesses were divided into the hemianopic and unaffected sides. The relationship between the time after stroke and the GCL+IPL thicknesses in the hemianopic side was evaluated. Results. The average thicknesses of the GCL+IPL were 64.6 and 82.0 μm on the hemianopic and unaffected sides, respectively, and the measurement was significantly thinner on the former side (p = 0.018). A regression analysis revealed a negative linear relationship (R (2) = 0.574, p = 0.049) between the time after stoke and the GCL+IPL thicknesses on the hemianopic side. The supratemporal and inferotemporal cpRNFL thicknesses in the eyes ipsilateral to the stroke showed a significant reduction. Conclusion. Our findings confirmed our previous observations that the degeneration of retinal ganglion cells can occur after PCA stroke. GCL+IPL thinning was demonstrated in the hemiretinae corresponding to the affected hemifields. Also, it is suggested that the retinal changes observed are progressive.
Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, Japan; Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan.
Tsutomu
T
Yamashita
Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, Japan; Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan.
Atsushi
A
Miki
Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan.
Katsutoshi
K
Goto
Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan.
Syunsuke
S
Araki
Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan.
Go
G
Takizawa
Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan.
Yoshiaki
Y
Ieki
Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan.
Junichi
J
Kiryu
Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, Japan.
Akio
A
Tabuchi
Department of Neurology, The Jikei University School of Medicine, Minato-ku, Tokyo 105-8471, Japan.
Yasuyuki
Y
Iguchi
Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo 113-8603, Japan.
Kazumi
K
Kimura
Department of Stroke Medicine, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan.
Yoshiki
Y
Yagita