Research on Acute Toxicity and Pharmacodynamics of Jinyulian Oral Solution.
A research on Jinyulian Oral Solution was conducted and the objectives were to discover its possible acute toxicity and antibacterial effects when used in vitro and in vivo. Regarding the acute toxicity test, Kunming mice were fed a maximum amount of the solution as their stomachs could hold, i.e., 40 mL kg(-1). To ascertain the minimum inhibitory concentration (MIC) of the solution, two types of germs, i.e., Staphylococcus aureus and Escherichia coli, were selected and tube dilution method was adopted. An antibacterial experimental model relying on animals' body was developed for the researchers to observe the solution's antibacterial effects. Test results showed that no abnormalities were discovered within 14 days after the initial date of testing and the mice grew as normal when fed with an amount of the solution 250 times of a normal clinical doze (In this case a man was assumed to weigh 60 kg.) and that the solution demonstrated obvious antibacterial effects on the two types of selected germs. The respective measured MIC50 and MIC90 values of the two germs were 3.2, 12.8, 6.4, and 25.6 mg L(-1). Therefore, it is reasonable to conclude that Jinyulian Oral Solution possesses no acute toxicity but obvious antibacterial effects on the two before-mentioned germs.
Department of Pharmacy, Suizhou Hospital, Hubei University of Medicine, Suizhou, 441300, Hubei Province, China.
Wan-Qing
WQ
Cheng
Department of Pharmacy, Suizhou Hospital, Hubei University of Medicine, Suizhou, 441300, Hubei Province, China.
Zhen-Jian
ZJ
Zhang
Department of Pharmacy, Suizhou Hospital, Hubei University of Medicine, Suizhou, 441300, Hubei Province, China. 837219178@qq.com.
Chuan-Bin
CB
Cao
Department of Pharmacy, Suizhou Hospital, Hubei University of Medicine, Suizhou, 441300, Hubei Province, China.
Xiao-Wen
XW
Ye
Microbial Chamber, The Hubei Provincial Food and Drug Supervision and Inspection Institute, Wuhan, 430064, Hubei Province, China.
Wang-Ping
WP
Pan
The Teaching and Research Group of Microbiology, Tongji Medical College, HUST, Wuhan, 430030, Hubei Province, China.
Si-Ying
SY
Ye
Department of Pharmacy, Suizhou Hospital, Hubei University of Medicine, Suizhou, 441300, Hubei Province, China.
Bo
B
Zhu
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity*; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D020128:Inhibitory Concentration 50; D008297:Male; D051379:Mice; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; C000613512:Jinyulian
Acute toxicity; Jinyulian Oral Solution; Pharmacodynamics