Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems.
Vaccination is one of the most popular technologies in disease prevention and eradication. It is promising to improve immunization efficiency by using vectors and/or adjuvant delivery systems. Nanoparticle (NP)-based delivery systems have attracted increasing interest due to enhancement of antigen uptake via prevention of vaccine degradation in the biological environment and the intrinsic immune-stimulatory properties of the materials. Mitochondria play paramount roles in cell life and death and are promising targets for vaccine delivery systems to effectively induce immune responses. In this review, we focus on NPs-based delivery systems with surfaces that can be manipulated by using mitochondria targeting moieties for intervention in health and disease.
NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. soso2012@uga.edu.
Ru
R
Wen
NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. aumeano@uga.edu.
Afoma C
AC
Umeano
NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. lgf39148@uga.edu.
Lily
L
Francis
NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. nivita.sharma97@uga.edu.
Nivita
N
Sharma
School of Medicine, Department of Pulmonary and Critical Care, University of Virginia, Charlottesville, WV 22908, USA. st2vk@virginia.edu.
Smanla
S
Tundup
NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. shanta@uga.edu.
Shanta
S
Dhar
antigen delivery; mitochondria targeting; nanoparticles; vaccine