Characteristics of the fibroplasia and collagen expression in the abdominal wall after implant of the polypropylene mesh and polypropylene/polyglecaprone mesh in rats.
OBJECTIVE
To compare fibroplasia and the resistance of the abdominal wall when polypropylene meshes and polypropylene/poliglecaprone are used.


METHODS
Seventy-seven male Wistar rats were divided into three groups: Control Group (for resistance); Group E (polypropylene mesh); and Group U (polypropylene/poliglecaprone mesh). The animals in Groups E and U had a standard muscular and aponeurotic defect, with integral peritoneum, and correction with the mesh. Measurements were taken 4, 7, 14, 28 and 56 days after surgery. The resistance, and collagen density were studied.


RESULTS
Resistance on the 56th day was similar in both meshes. The gain in resistance described an ascending curve for the polypropylene mesh and was irregular in the case of the polypropylene/poliglecaprone. Fibroplasia showed a gain in type I and type III collagen in both groups (p<0.001). Collagen III stabilized in the 14th day and collagen I continued to ascend.


CONCLUSIONS
The gain in resistance of the polypropylene mesh is regular and ascending, whereas the polypropylene/poliglecaprone is not regular. The final resistance of both meshes is similar; the collagen density increases over time, and show the same inflammatory potential.
PhD, Associate Professor, Department of Surgery, Universidade Federal do Paraná (UFPR), Brazil. Intellectual and design of the study, analysis of data, manuscript writing, final approval the version to be published., Universidade Federal do Paraná, Department of Surgery, Universidade Federal do Paraná, Brazil.
Maria de Lourdes Pessole
Mde L
Biondo-Simões
Graduate student, Scientific Initiation Program, UFPR, Curitiba-PR, Brazil. Technical procedures., Universidade Federal do Paraná, UFPR, Curitiba PR , Brazil.
Camila Gomes de
CG
Morais
Graduate student, Scientific Initiation Program, UFPR, Curitiba-PR, Brazil. Technical procedures., Universidade Federal do Paraná, UFPR, Curitiba PR , Brazil.
Anna Flávia Zonato
AF
Tocchio
Graduate student, Scientific Initiation Program, UFPR, Curitiba-PR, Brazil. Technical procedures., Universidade Federal do Paraná, UFPR, Curitiba PR , Brazil.
Renata Augusta de
RA
Miranda
Graduate student, Scientific Initiation Program, UFPR, Curitiba-PR, Brazil. Technical procedures., Universidade Federal do Paraná, UFPR, Curitiba PR , Brazil.
Paula Almeida Pamponet
PA
Moura
Graduate student, Scientific Initiation Program, UFPR, Curitiba-PR, Brazil. Technical procedures., Universidade Federal do Paraná, UFPR, Curitiba PR , Brazil.
Kelly
K
Colla
Master, Full Professor, Department of Anesthesiology, Faculty of Veterinary Medicine, UFPR, Curitiba-PR, Brazil. Analgesia and post-operatory care, manuscript writing., Universidade Federal do Paraná, Department of Anesthesiology, Faculty of Veterinary Medicine, UFPR, Curitiba PR , Brazil.
Rogério Ribeiro
RR
Robes
PhD, Associate Professor, Division of Pathology, Pontifícia Universidade Católica do Paraná (PUCPR), and UFPR, Curitiba-PR, Brazil. Critical revision., Pontifícia Universidade Católica do Paraná, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba PR , Brazil.
Sérgio Ossamu
SO
Ioshii
PhD, Head, Division of Experimental Surgery, Department of Surgery, UFPR, Curitiba-PR, Brazil. English language, critical revision., Universidade Federal do Paraná, Department of Surgery, UFPR, Curitiba PR , Brazil.
Flávio Daniel Saavedra
FD
Tomasich
D034861:Abdominal Wall / Q000601:surgery*; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D024042:Collagen Type I / Q000378:metabolism; D024061:Collagen Type III / Q000378:metabolism; D004146:Dioxanes / Q000627:therapeutic use*; D000069290:Incisional Hernia / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008422:Materials Testing / Q000295:instrumentation; D023421:Models, Animal; D011091:Polyesters / Q000627:therapeutic use*; D011126:Polypropylenes / Q000627:therapeutic use*; D011184:Postoperative Period; D017208:Rats, Wistar; D013526:Surgical Mesh; D013718:Tensile Strength / Q000502:physiology; D014945:Wound Healing
D024042:Collagen Type I; D024061:Collagen Type III; D004146:Dioxanes; D011091:Polyesters; D011126:Polypropylenes; C095495:glycolide E-caprolactone copolymer; D003094:Collagen