Small-Animal Imaging Using Diffuse Fluorescence Tomography.
Diffuse fluorescence tomography (DFT) has been developed to image the spatial distribution of fluorescence-tagged tracers in living tissue. This capability facilitates the recovery of any number of functional parameters, including enzymatic activity, receptor density, blood flow, and gene expression. However, deploying DFT effectively is complex and often requires years of know-how, especially for newer mutlimodal systems that combine DFT with conventional imaging systems. In this chapter, we step through the process of using MRI-DFT imaging of a receptor-targeted tracer in small animals.
Thayer School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH, 03755, USA. scott.c.davis@dartmouth.edu.
Scott C
SC
Davis
Armour College of Engineering, Illinois Institute of Technology, Chicago, IL, USA.
Kenneth M
KM
Tichauer
D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D051379:Mice; D057054:Molecular Imaging / Q000295:instrumentation; D064847:Multimodal Imaging; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000000981:diagnostic imaging*; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods; D051598:Whole Body Imaging / Q000295:instrumentation*
Anatomical priors; Cancer; Diffuse optics; Fluorescence; Image reconstruction; MRI; Molecular imaging; Mutlimodal imaging; NIRFAST