[Regulation of neurogenesis: factors affecting of new neurons formation in adult mammals brain].
Neurogenesis is a complex and multi-step process of generating completely functional neurons. This process in adult brain is based on pluripotentional neuronal stem cells (NSC), which are able to proliferation and differentiation into mature neurons or glial cells. NSC are located in subgranular zone inside hippocampus and in subventricular zone. The new neurons formation depends on many endo- and exogenous factors which modulate each step of neurogenesis. This article describes the most important regulators of adult neurogenesis, mainly: neurotrophins, growth factors, hormones, neurotransmitters and microenvironment of NSC. Some drugs, especially antipsychotics, antidepressants and normothymics may affect the neurogenic properties of adult brain. Moreover pathological processes such as neuroinflammation, stroke or epilepsy are able to induce proliferation of NSC. The proneurogenic effects of psychotropic drugs and pathological processes are associated with their ability to increase some hormones and neurotrophins level, as well as with rising the expression of antiapoptotic Bcl-2 protein and metalloproteinase MMP-2. Additionaly, some drugs, for example haloperidol, are able to block prolactin and dopaminergic neuroblasts receptors. Down-regulation of adult neurogenesis is associated with alcohol abuse and high stress level. Negative effect of many drugs, such as cytostatics, COX-2 inhibitors and opioides was also observed. The proneurogenic effect of described factors suggest their broad therapeutic potential and gives a new perspective on an effective and modern treatment of many neuropsychiatric disorders. This effect can also help to clarify the pathogenesis of disorders associated with proliferation and degeneration of adult brain cells.
Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej w Sosnowcu, Śląski Uniwersytet Medyczny w Katowicach, Katedra i Zakład Chemii i Analizy Leków w Sosnowcu.
Michalina
M
Respondek
Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej w Sosnowcu, Śląski Uniwersytet Medyczny w Katowicach, Katedra i Zakład Chemii i Analizy Leków w Sosnowcu.
Ewa
E
Buszman
D000328:Adult; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001921:Brain / Q000166:cytology*; D002454:Cell Differentiation / Q000187:drug effects; D015536:Down-Regulation; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D008322:Mammals; D001523:Mental Disorders / Q000503:physiopathology; D055495:Neurogenesis / Q000502:physiology*; D009457:Neuroglia; D009474:Neurons / Q000378:metabolism*; D011619:Psychotropic Drugs / Q000494:pharmacology; D013234:Stem Cells; D020521:Stroke
D000928:Antidepressive Agents; D011619:Psychotropic Drugs