Cobalt-Catalyzed C(sp(2) )-H Methylation by using Dicumyl Peroxide as both the Methylating Reagent and Hydrogen Acceptor.
The first cobalt-catalyzed direct methylation of a C(sp(2) )-H bond using dicumyl peroxide (DCP) as both the methylating reagent and hydrogen acceptor has been established. The reaction proceeded without the use of any additives, and was proven to be applicable to various amides bearing a 2-pyridinylisopropyl (PIP) directing group, providing an efficient access to o-methyl aryl amides with high functional-group tolerance. Preliminary mechanistic studies suggest a radical process would be involved in the catalytic process.
Institute of Chemistry & BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Qun
Q
Li
Institute of Chemistry & BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Yanrong
Y
Li
Institute of Chemistry & BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Weipeng
W
Hu
Institute of Chemistry & BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Renjian
R
Hu
Institute of Chemistry & BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China. guigenli@nju.edu.cn.|Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, 79409-1061, USA. guigenli@nju.edu.cn.
Guigen
G
Li
Institute of Chemistry & BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China. hongjianlu@nju.edu.cn.
Hongjian
H
Lu
C−H functionalization; amides; cobalt; methylation; peroxide