JAK1 Takes a FERM Hold of Type II Cytokine Receptors.
Janus kinases (JAKs) initiate the intracellular signaling cascade triggered by exposure of cells to cytokines and interferons. In order to achieve this, JAKs are bound to the intracellular domain of specific cytokine receptors immediately adjacent to the cell membrane. In this issue of Structure, Ferrao et al. (2016) provide structural details of such an interaction and in doing so, identify for the first time the motif used by type II cytokine receptors to recruit JAK1.
Department of Medical Biology, The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, VIC 3052, Australia. Electronic address: babon@wehi.edu.au.
Jeffrey J
JJ
Babon
Department of Medical Biology, The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, VIC 3052, Australia.
Nicholas P D
NP
Liau
Department of Medical Biology, The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, VIC 3052, Australia.
Nadia J
NJ
Kershaw
D002462:Cell Membrane; D053613:Janus Kinase 1 / Q000737:chemistry*; D011505:Protein-Tyrosine Kinases / Q000737:chemistry; D018121:Receptors, Cytokine / Q000737:chemistry*; D015398:Signal Transduction
D018121:Receptors, Cytokine; D011505:Protein-Tyrosine Kinases; D053613:Janus Kinase 1