Synthesis and antituberculosis activity of the first macrocyclic glycoterpenoids comprising glucosamine and diterpenoid isosteviol.
The first macrocyclic glycoterpenoids comprising glucosamine and diterpenoid isosteviol moieties were synthesized and evaluated for inhibition activity against Mycobacterium tuberculosis H37Rv.
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str., 8, Kazan, 420088, Russia.
Bulat F
BF
Garifullin
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str., 8, Kazan, 420088, Russia.
Irina Yu
IY
Strobykina
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str., 8, Kazan, 420088, Russia.
Radmila R
RR
Sharipova
Ural Research Institute for Phtisiopulmonology, Ministry of Health Protection of the Russian Federation, XX Parts'ezda str., 50, Yekaterinburg, 620039, Russia.
Marionella A
MA
Kravchenko
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str., 8, Kazan, 420088, Russia.
Olga V
OV
Andreeva
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str., 8, Kazan, 420088, Russia.
Olga B
OB
Bazanova
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Arbuzova str., 8, Kazan, 420088, Russia. Electronic address: kataev@iopc.ru.
Vladimir E
VE
Kataev
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000737:chemistry*; D005944:Glucosamine / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013329:Structure-Activity Relationship
D000995:Antitubercular Agents; D045786:Diterpenes, Kaurane; D047028:Macrocyclic Compounds; C515747:isosteviol; D005944:Glucosamine
Antitubercular; Glucosamine; Glycoconjugates; Glycosides; Glycoterpenoids; Isosteviol; Macrocyclic; Tuberculosis