Thermal and magnetic properties of chitosan-iron oxide nanoparticles.
Chitosan is a biopolymer widely used for biomedical applications such as drug delivery systems, wound healing, and tissue engineering. Chitosan can be used as coating for other types of materials such as iron oxide nanoparticles, improving its biocompatibility while extending its range of applications. In this work iron oxide nanoparticles (Fe3O4 NPs) produced by chemical precipitation and thermal decomposition and coated with chitosan with different molecular weights were studied. Basic characterization on bare and chitosan-Fe3O4 NPs was performed demonstrating that chitosan does not affect the crystallinity, chemical composition, and superparamagnetic properties of the Fe3O4 NPs, and also the incorporation of Fe3O4 NPs into chitosan nanoparticles increases the later hydrodynamic diameter without compromising its physical and chemical properties. The nano-composite was tested for magnetic hyperthermia by applying an alternating current magnetic field to the samples demonstrating that the heating ability of the Fe3O4 NPs was not significantly affected by chitosan.
i3N/CENIMAT, Department of Materials Science, Faculty of Science and Technology, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal.
Paula I P
PI
Soares
i3N/CENIMAT, Department of Materials Science, Faculty of Science and Technology, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal.
Diana
D
Machado
Laboratório Associado para a Química Verde (LAQV), REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, FCT, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal.
César
C
Laia
IST/C2TN, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, ao km 139,7, 2695-066 Bobadela LRS, Portugal.
Laura C J
LC
Pereira
IST/C2TN, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, ao km 139,7, 2695-066 Bobadela LRS, Portugal.
Joana T
JT
Coutinho
i3N/CENIMAT, Department of Materials Science, Faculty of Science and Technology, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal.
Isabel M M
IM
Ferreira
Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa, IHMT/UNL, 1349-008 Lisboa, Portugal.
Carlos M M
CM
Novo
i3N/CENIMAT, Department of Materials Science, Faculty of Science and Technology, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal. Electronic address: imf@fct.unl.pt.
João Paulo
JP
Borges
D048271:Chitosan / Q000737:chemistry*; D060328:Magnetic Phenomena; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008970:Molecular Weight; D013696:Temperature
D058185:Magnetite Nanoparticles; D048271:Chitosan
Chitosan; Iron oxide nanoparticles; Magnetic hyperthermia; Magnetite