Lanostane Triterpenes Isolated from Antrodia heteromorpha and Their Inhibitory Effects on RANKL-Induced Osteoclastogenesis.
Two new spiro-lanostane triterpenoids, antrolactones A and B (1 and 2), along with polyporenic acid C (3), were isolated from an EtOAc-soluble extract of Antrodia heteromorpha culture medium, and the chemical structures of the new compounds were elucidated by application of NMR, MS, and ECD spectroscopic techniques. All isolated compounds exhibited inhibitory effects on receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis.
Jaeyoung
J
Kwon
Hyaemin
H
Lee
Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju 28116, Republic of Korea.
Yeo Dae
YD
Yoon
College of Pharmacy, Chungbuk National University , Cheongju 28644, Republic of Korea.
Bang Yeon
BY
Hwang
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300353, People's Republic of China.
Yuanqiang
Y
Guo
Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju 28116, Republic of Korea.
Jong Soon
JS
Kang
Jae-Jin
JJ
Kim
Dongho
D
Lee
D055491:Antrodia / Q000737:chemistry*; D007810:Lanosterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010012:Osteogenesis / Q000187:drug effects*; D053245:RANK Ligand / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D053245:RANK Ligand; C505688:TNFSF11 protein, human; D014315:Triterpenes; C000618893:antrolactone A; C000618894:antrolactone B; D007810:Lanosterol; C476268:polyporenic acid C