[In vitro generation of blood red cells from stem cells: a sketch of the future].
Human adult pluripotent stem cells, stem cells of embryonic origin and induced pluripotent stem cells (iPS) provide cellular sources for new promising regenerative medicine approaches. Because these cells can be patient-specific, they allow considering a personalized medicine appropriate to the diagnosis of each. The generation of cultured red blood cells (cRBC) derived from stem cells is emblematic of personalized medicine. Indeed, these cells have the advantage of being selected according to a blood phenotype of interest and they may provide treatments to patients in situation of impossible transfusion (alloimmunized patients, rare phenotypes). Essential progresses have established proof of concept for this approach, still a concept some years ago. From adult stem cells, all steps of upstream research were successfully achieved, including the demonstration of the feasibility of injection into human. This leads us to believe that Red Blood Cells generated in vitro from stem cells will be the future players of blood transfusion. However, although theoretically ideal, these stem cells raise many biological challenges to overcome, although some tracks are identified.
INSERM, UMRS938, Prolifération et différenciation des cellules souches, 75012 Paris, France - Etablissement Français du Sang Ile de France, Unité d'ingénierie et de thérapie cellulaire, 94017 Créteil, France - UPMC Université ParisVI, UMRS938 CDR Saint-Antoine, Prolifération et différenciation des cellules souches, 75012 Paris, France.
Christelle
C
Mazurier
INSERM, UMRS938, Prolifération et différenciation des cellules souches, 75012 Paris, France - Etablissement Français du Sang Ile de France, Unité d'ingénierie et de thérapie cellulaire, 94017 Créteil, France - UPMC Université ParisVI, UMRS938 CDR Saint-Antoine, Prolifération et différenciation des cellules souches, 75012 Paris, France - AP-HP, Hôpital Armand Trousseau et Saint-Antoine, Service d'Hématologie et Immunologie Biologiques, 75012 Paris, France.
Luc
L
Douay
D000328:Adult; D053687:Adult Stem Cells / Q000502:physiology; D018929:Cell Culture Techniques / Q000379:methods; D002478:Cells, Cultured; D004912:Erythrocytes / Q000502:physiology*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology*; D057285:Precision Medicine / Q000379:methods / Q000639:trends; D044968:Regenerative Medicine / Q000639:trends*