Rational Design of Peptide Vaccines Against Multiple Types of Human Papillomavirus.
Human papillomavirus (HPV) occurs in many types, some of which cause cervical, genital, and other cancers. While vaccination is available against the major cancer-causing HPV types, many others are not covered by these preventive measures. Herein, we present a bioinformatics study for the designing of multivalent peptide vaccines against multiple HPV types as an alternative strategy to the virus-like particle vaccines being used now. Our technique of rational design of peptide vaccines is expected to ensure stability of the vaccine against many cycles of mutational changes, elicit immune response, and negate autoimmune possibilities. Using the L1 capsid protein sequences, we identified several peptides for potential vaccine design for HPV 16, 18, 33, 35, 45, and 11 types. Although there are concerns about the epitope-binding affinities for the peptides identified in this process, the technique indicates possibilities of multivalent, adjuvanted, peptide vaccines against a wider range of HPV types, and tailor-made different combinations of the peptides to address frequency variations of types over different population groups as required for prophylaxis and at lower cost than are in use at the present time.
Centre for Interdisciplinary Research and Education, Kolkata, India.
Sumanta
S
Dey
Centre for Interdisciplinary Research and Education, Kolkata, India.
Antara
A
De
Centre for Interdisciplinary Research and Education, Kolkata, India.
Ashesh
A
Nandy
continuous-discontinuous epitopes; graphical representation; human papillomavirus; multivalent peptide vaccines; protein graph radius; rational design of peptide vaccines