From the Rodent Spinal Cord Injury Model to Human Application: Promises and Challenges.
Repair of the spinal cord and improvement of mobility after injury has been a matter of basic and clinical research for several decades. A number of repair approaches were performed in animals, mainly rodent models of spinal cord injury (SCI). Some of these experimental therapies resulted in significant regeneration of tract fibers, formation of new connections and circuits, and associated improvement of mobility. Some clinical trials aiming at translating these approaches to the human condition of an SCI are currently on-going. The present therapy, however, remains rehabiliation: Mobility of patients with an SCI can be improved to a limited extent by the exploition of neuroplasticity. In this article the present state of the art in the field of SCI research will be discussed. Studies dealing with the promotion of spinal cord repair and those directed to improve mobility by exploition of neuroplasticity will be summarized. The promises and challenges of translational basic research in rodent SCI models will be presented.
1 Spinal Cord Injury Center, University Hospital Balgrist , Zürich, Switzerland .
Volker
V
Dietz
2 University and ETH , Zürich, Switzerland .
Martin E
ME
Schwab
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D009416:Nerve Regeneration; D010806:Physical Education and Training; D012377:Rodentia; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000534:rehabilitation; D058630:Spinal Cord Regeneration
neuroplasticity; rodent SCI models; spinal cord injury (SCI); spinal cord repair; translational research