Metabolic programming in chronically stimulated T cells: Lessons from cancer and viral infections.
T-cell metabolism is central to the shaping of a successful immune response. However, there are pathological situations where T cells are rendered dysfunctional and incapable of eliminating infected or transformed cells. Here, we review the current knowledge on T-cell metabolism and how persistent antigenic stimulation, in the form of cancer and chronic viral infection, modifies both metabolic and functional pathways in T cells.
Institute for Medical Immunology, Université Libre de Bruxelles (ULB), Gosselies, Belgium.
Marie
M
Bettonville
Institute for Medical Immunology, Université Libre de Bruxelles (ULB), Gosselies, Belgium.
Stefania
S
D'Aria
Institute for Medical Immunology, Université Libre de Bruxelles (ULB), Gosselies, Belgium.
Michel Y
MY
Braun
D000220:Adaptation, Biological / Q000235:genetics / Q000276:immunology; D000818:Animals; D000941:Antigens / Q000276:immunology; D065150:Cellular Reprogramming / Q000235:genetics / Q000276:immunology*; D004734:Energy Metabolism / Q000235:genetics / Q000276:immunology*; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D014777:Virus Diseases / Q000276:immunology / Q000378:metabolism
D000941:Antigens
Cancer; Chronic infection; Metabolism; Negative regulatory receptors; T cells