Nanotechnology in hyperthermia cancer therapy: From fundamental principles to advanced applications.
In this work, we present an in-depth review of recent breakthroughs in nanotechnology for hyperthermia cancer therapy. Conventional hyperthermia methods do not thermally discriminate between the target and the surrounding normal tissues, and this non-selective tissue heating can lead to serious side effects. Nanotechnology is expected to have great potential to revolutionize current hyperthermia methods. To find an appropriate place in cancer treatment, all nanotechnology-based hyperthermia methods and their risks/benefits must be thoroughly understood. In this review paper, we extensively examine and compare four modern nanotechnology-based hyperthermia methods. For each method, the possible physical mechanisms of heat generation and enhancement due to the presence of nanoparticles are explained, and recent in vitro and in vivo studies are reviewed and discussed. Nano-Photo-Thermal Therapy (NPTT) and Nano-Magnetic Hyperthermia (NMH) are reviewed as the two first exciting approaches for targeted hyperthermia. The third novel hyperthermia method, Nano-Radio-Frequency Ablation (NaRFA) is discussed together with the thermal effects of novel nanoparticles in the presence of radiofrequency waves. Finally, Nano-Ultrasound Hyperthermia (NUH) is described as the fourth modern method for cancer hyperthermia.
Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Jaber
J
Beik
Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Ziaeddin
Z
Abed
Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Fatemeh S
FS
Ghoreishi
Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Samira
S
Hosseini-Nami
Department of Pharmacology, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Saeed
S
Mehrzadi
Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran; Clinical Nanomedicine Lab., ENT and Head & Neck Research Center and Department, Iran University of Medical Sciences (IUMS), Tehran, Iran; Diagnostic Nanoparticles Research Core, Iran University of Medical Sciences (IUMS), Tehran, Iran. Electronic address: shakeriz@iums.ac.ir.
Ali
A
Shakeri-Zadeh
Clinical Nanomedicine Lab., ENT and Head & Neck Research Center and Department, Iran University of Medical Sciences (IUMS), Tehran, Iran; Diagnostic Nanoparticles Research Core, Iran University of Medical Sciences (IUMS), Tehran, Iran; Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran. Electronic address: skkamrava@yahoo.com.
S Kamran
SK
Kamrava
D000818:Animals; D017115:Catheter Ablation; D006801:Humans; D006979:Hyperthermia, Induced; D060328:Magnetic Phenomena; D036103:Nanotechnology; D009369:Neoplasms / Q000628:therapy*; D010778:Photochemotherapy
Alternative magnetic fields; Cancer hyperthermia; Laser; Nanotechnology; Radiofrequency waves; Ultrasound