Response of keloid fibroblasts to Vitamin D3 and quercetin treatment - in vitro study.
Keloid scars continue to pose a challenge to clinicians as the treatment armamentarium lacks a formidable agent to tackle them. We have undertaken an in vitro study based on the mechanism of action of Vitamin D3 and quercetin on isolated keloid fibroblasts. Dose-dependent action on the reduction of cellular proliferation, collagen synthesis and induction of apoptosis by Vitamin D3 and quercetin are analyzed and probable mechanism of action is elaborated. This study thus opens up newer avenues in tackling keloid scars effectively.
CHILDS Trust Medical Research Foundation and Kanchi Kamakoti Childs Trust Hospital, Chennai, India.
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Mathangi Ramakrishnan
CHILDS Trust Medical Research Foundation and Kanchi Kamakoti Childs Trust Hospital, Chennai, India.
M
M
Babu
Dept. of Biochemistry and Cell Biology Cavin Kare Research Centre, Chennai, India.
M S
MS
Lakshmi Madhavi
apoptosis; keloid fibroblasts; quercetin; vitamin D3