A Novel Peptide Hydrogel for an Antimicrobial Bandage Contact Lens.
A peptide hydrogel with an antimicrobial activity is developed as a bandage contact lens. The antimicrobial activity is enhanced with the addition of the biomolecules penicillin G or poly-ε-lysine and is positive against Staphylococcus aureus and Escherichia coli. The lens is also noncytotoxic toward a human corneal epithelial cell line and as a consequence is of great potential as a drug-eluting bandage lens replacing conventional corneal ulcer treatment.
Institute of Ageing and Chronic Diseases, Department of Eye and Vision Science, University of Liverpool, Apex Building, West Derby Street, Liverpool, L7 8TX, UK.|SpheriTech Ltd, The Heath Business and Technical Park, Runcorn, Cheshire, WA7 4QX, UK.
Andrew G
AG
Gallagher
Institute of Integrative Biology, University of Liverpool, Biosciences Building, Crown Street, Liverpool, L69 7ZB, UK.
Jamal A
JA
Alorabi
SpheriTech Ltd, The Heath Business and Technical Park, Runcorn, Cheshire, WA7 4QX, UK.
Donald A
DA
Wellings
Institute of Ageing and Chronic Diseases, Department of Eye and Vision Science, University of Liverpool, Apex Building, West Derby Street, Liverpool, L7 8TX, UK.
Rebecca
R
Lace
Institute of Integrative Biology, University of Liverpool, Biosciences Building, Crown Street, Liverpool, L69 7ZB, UK.
Mal J
MJ
Horsburgh
Institute of Ageing and Chronic Diseases, Department of Eye and Vision Science, University of Liverpool, Apex Building, West Derby Street, Liverpool, L7 8TX, UK.
Rachel L
RL
Williams
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D003261:Contact Lenses; D003315:Cornea / Q000382:microbiology; D004847:Epithelial Cells / Q000382:microbiology; D004926:Escherichia coli / Q000254:growth & development*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D010400:Penicillin G / Q000737:chemistry / Q000494:pharmacology; D011107:Polylysine / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000254:growth & development*
D000900:Anti-Bacterial Agents; D020100:Hydrogels; D011107:Polylysine; D010400:Penicillin G
antimicrobial; bandage lens; cornea; drug delivery; hydrogel