Cognition and eating behavior in amyotrophic lateral sclerosis: effect on survival.
It is increasingly recognized that metabolic factors influenced by eating behavior, may affect disease progression in neurodegeneration. In frontotemporal dementia (FTD), which shares a significant overlap with Amyotrophic lateral sclerosis (ALS), patients are well known to develop changes in eating behavior. Whether patients with pure ALS and those with cognitive and behavioral changes associated with ALS also develop similar changes is not known. The current study aimed to examine caloric intake, eating behavioral changes, body mass index, and using cox regression analyses survival across the spectrum of 118 ALS-FTD patients (29 pure ALS, 12 ALS-plus and 21 ALS-FTD, 56 behavioral variant FTD), compared with 25 control subjects. The current study found contrary to previous assumptions eating changes are not restricted to FTD, but a spectrum of eating behavioral changes occur in ALS, present in those with pure ALS and worsening as patients develop cognitive changes. ALS patients with cognitive impairment exhibited changes in food preference, with caloric intake and BMI increasing with the development of cognitive/behavioral changes. Both pure ALS and those with cognitive impairment demonstrated increased saturated fat intake. Survival analyses over the mean patient follow-up period of 6.9 years indicated that increasing eating behavioral changes were associated with an improved survival (threefold decrease risk of dying). Changes in eating behavior and metabolism occur in ALS in association with increasing cognitive impairment, perhaps exerting a protective survival influence. These changes provide insights into the common neural networks controlling eating and metabolism in FTD and ALS and provide potential targets to modify disease prognosis and progression.
ForeFront Clinic, Brain and Mind Centre and Sydney Medical School, University of Sydney, 94 Mallett St, Camperdown, NSW, 2050, Australia. rebekah.ahmed@sydney.edu.au.|Neuroscience Research Australia, Sydney, Australia. rebekah.ahmed@sydney.edu.au.|University of New South Wales, Sydney, Australia. rebekah.ahmed@sydney.edu.au.|ARC Centre of Excellence in Cognition and Its Disorders, The University of New South Wales, Sydney, Australia. rebekah.ahmed@sydney.edu.au.
R M
RM
Ahmed
ForeFront Clinic, Brain and Mind Centre and Sydney Medical School, University of Sydney, 94 Mallett St, Camperdown, NSW, 2050, Australia.
J
J
Caga
ForeFront Clinic, Brain and Mind Centre and Sydney Medical School, University of Sydney, 94 Mallett St, Camperdown, NSW, 2050, Australia.|Neuroscience Research Australia, Sydney, Australia.|University of New South Wales, Sydney, Australia.|ARC Centre of Excellence in Cognition and Its Disorders, The University of New South Wales, Sydney, Australia.
E
E
Devenney
ForeFront Clinic, Brain and Mind Centre and Sydney Medical School, University of Sydney, 94 Mallett St, Camperdown, NSW, 2050, Australia.
S
S
Hsieh
Neuroscience Research Australia, Sydney, Australia.
L
L
Bartley
ForeFront Clinic, Brain and Mind Centre and Sydney Medical School, University of Sydney, 94 Mallett St, Camperdown, NSW, 2050, Australia.
E
E
Highton-Williamson
ForeFront Clinic, Brain and Mind Centre and Sydney Medical School, University of Sydney, 94 Mallett St, Camperdown, NSW, 2050, Australia.
E
E
Ramsey
ForeFront Clinic, Brain and Mind Centre and Sydney Medical School, University of Sydney, 94 Mallett St, Camperdown, NSW, 2050, Australia.
M
M
Zoing
Neuroscience Research Australia, Sydney, Australia.|University of New South Wales, Sydney, Australia.
G M
GM
Halliday
Neuroscience Research Australia, Sydney, Australia.|University of New South Wales, Sydney, Australia.|ARC Centre of Excellence in Cognition and Its Disorders, The University of New South Wales, Sydney, Australia.
O
O
Piguet
Neuroscience Research Australia, Sydney, Australia.|University of New South Wales, Sydney, Australia.|ARC Centre of Excellence in Cognition and Its Disorders, The University of New South Wales, Sydney, Australia.
J R
JR
Hodges
ForeFront Clinic, Brain and Mind Centre and Sydney Medical School, University of Sydney, 94 Mallett St, Camperdown, NSW, 2050, Australia.
M C
MC
Kiernan
D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications* / Q000401:mortality*; D000704:Analysis of Variance; D001315:Australia; D003072:Cognition Disorders / Q000209:etiology*; D015331:Cohort Studies; D004435:Eating; D005247:Feeding Behavior / Q000502:physiology*; D001068:Feeding and Eating Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D006815:Hunger; D008297:Male; D008875:Middle Aged; D010808:Physical Examination; D012528:Satiety Response
Amyotrophic lateral sclerosis; Eating; Frontotemporal dementia; Hypothalamus; Metabolism; Neurodegeneration; Neuroendocrine