PPARG gene C161T CT/TT associated with lower blood lipid levels and ischemic stroke from large-artery atherosclerosis in a Han population in Guangdong.
OBJECTIVE
Peroxisome proliferator-activated receptor gamma (PPARG) is a transcription factor involved in atherosclerosis and related diseases. In this study, we aimed to investigate whether PPARG C161T was associated with lipid levels and large-artery atherosclerosis (LAA) ischemic stroke in a Han Chinese population in Guangdong province.


METHODS
The genotype PPARG C161T in 149 LAA ischemic stroke patients and 125 healthy controls was examined by polymerase chain reaction-restriction fragment length polymorphism (RFLP) assay. Associations with LAA ischemic stroke were analyzed for PPARG C161T genotype, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), and a logistic regression analysis was performed to identify risk factors for LAA ischemic stroke.


RESULTS
The frequency of CC was higher than that of CT + TT and was significantly associated with LAA ischemic stroke. In both the LAA and control groups, TC and LDL-C levels were significantly higher in the CC type than the CT + TT, but TG and HDL-C levels were comparable. The only verified independent risk factors for LAA ischemic stroke were ischemic heart disease (OR: 2.784, 95% CI: 1.377-5.632; p = 0.004) and systolic blood pressure (OR: 1.014, 95% CI: 1.001-1.026; p = 0.029); the PPARG C161T allele was not independently associated with an increased risk of LAA ischemic stroke (OR = 0.697, 95% CI: 0.372-1.305; p = 0.260).


CONCLUSIONS
In this Han population, PPARG C161T CT/TT was associated with LAA ischemic stroke and lower levels of blood TC and LDL-C, but was not an independent risk factor for LAA ischemic stroke.
a Department of Neurology , The Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-sen University) , Guangzhou , China.
Wei-Min
WM
Wei
a Department of Neurology , The Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-sen University) , Guangzhou , China.
Xiao-Yan
XY
Wu
a Department of Neurology , The Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-sen University) , Guangzhou , China.
Shu-Ting
ST
Li
a Department of Neurology , The Zengcheng People's Hospital (Boji-Affiliated Hospital of Sun Yat-sen University) , Guangzhou , China.
QingYu
Q
Shen
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000150:complications* / Q000208:ethnology / Q000235:genetics; D002681:China; D004252:DNA Mutational Analysis; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007511:Ischemia / Q000150:complications / Q000209:etiology / Q000235:genetics; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D047495:PPAR gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012189:Retrospective Studies; D020521:Stroke / Q000097:blood / Q000209:etiology / Q000235:genetics
D008055:Lipids; D047495:PPAR gamma
C161T; Ischemic stroke; Large-artery atherosclerosis; PPARG