[Chemical Exchange Saturation Transfer Imaging of Creatine Metabolites: a 3.0 T MRI Pilot].
OBJECTIVE
To determine the feasibility of using chemical exchange saturation transfer (CEST) imaging to measure creatine (Cr) metabolites with 3.0 T MR.


METHODS
Phantoms containing different concentrations of Cr under various pH conditions were studied with CEST sequence on 3.0 T MR imaging. CEST effect and Z spectra were analyzed.


RESULTS
Cr exhibited significant CEST effect (± 1.8 ppm, F = 99.08, P < 0.001) on 3.0 T MR imaging, and positive correlation was found between the signal intensity and concentration of Cr (r = 0.963, P < 0.001). The CEST effect showed pH dependency of Cr (r = 0.41, P = 0.035).


CONCLUSIONS
Creatine CEST imaging can be performed on 3.0 T MR imaging. Creatine concentrations and pH influence CEST effect.
Ying-kun
YK
Guo
Zhen-lin
ZL
Li
Yu
Y
Rong
Chun-chao
CC
Xia
Li-zhi
LZ
Zhang
Wan-ling
WL
Peng
Xi
X
Liu
Hua-yan
HY
Xu
Ti-jiang
TJ
Zhang
Pan-li
PL
Zuo
Benjamin
B
Schmitt
D003401:Creatine / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D019047:Phantoms, Imaging
D003401:Creatine