Association of Trabecular Bone Score with Inflammation and Adiposity in Patients with Psoriasis: Effect of Adalimumab Therapy.
Studies on trabecular bone score (TBS) in psoriasis are lacking. We aim to assess the association between TBS and inflammation, metabolic syndrome features, and serum adipokines in 29 nondiabetic patients with psoriasis without arthritis, before and after 6-month adalimumab therapy. For that purpose, adjusted partial correlations and stepwise multivariable linear regression analysis were performed. No correlation was found between TBS and disease severity. TBS was negatively associated with weight, BMI, waist perimeter, fat percentage, and systolic and diastolic blood pressure before and after adalimumab. After 6 months of therapy, a negative correlation between TBS and insulin resistance (p = 0.02) and leptin (p = 0.01) and a positive correlation with adiponectin were found (p = 0.01). The best set of predictors for TBS values at baseline were female sex (p = 0.015), age (p = 0.05), and BMI (p = 0.001). The best set of predictors for TBS following 6 months of biologic therapy were age (p = 0.001), BMI (p < 0.0001), and serum adiponectin levels (p = 0.027). In conclusion, in nondiabetic patients with moderate-to-severe psoriasis, TBS correlates with metabolic syndrome features and inflammation. This association is still present after 6 months of adalimumab therapy. Moreover, serum adiponectin levels seem to be an independent variable related to TBS values, after adalimumab therapy.
Bone Metabolism Unit, Department of Internal Medicine, Hospital Marqués de Valdecilla-IDIVAL, University of Cantabria, RETICEF, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
José L
JL
Hernández
Division of Rheumatology, Hospital Marqués de Valdecilla-IDIVAL, University of Cantabria, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
Raquel
R
López-Mejías
Division of Rheumatology, Hospital Marqués de Valdecilla-IDIVAL, University of Cantabria, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
Ricardo
R
Blanco
Division of Rheumatology, Hospital Marqués de Valdecilla-IDIVAL, University of Cantabria, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
Trinitario
T
Pina
Bone Metabolism Unit, Department of Internal Medicine, Hospital Marqués de Valdecilla-IDIVAL, University of Cantabria, RETICEF, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
Sheila
S
Ruiz
Bone Metabolism Unit, Department of Internal Medicine, Hospital Marqués de Valdecilla-IDIVAL, University of Cantabria, RETICEF, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
Isabel
I
Sierra
Division of Rheumatology, Hospital Marqués de Valdecilla-IDIVAL, University of Cantabria, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
Begoña
B
Ubilla
Division of Rheumatology, Hospital Marqués de Valdecilla-IDIVAL, University of Cantabria, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
Verónica
V
Mijares
Division of Dermatology, Hospital Marqués de Valdecilla, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
Marcos A
MA
González-López
Division of Dermatology, Hospital Marqués de Valdecilla, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
Susana
S
Armesto
Division of Rheumatology, Hospital Marqués de Valdecilla-IDIVAL, University of Cantabria, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
Alfonso
A
Corrales
Division of Rheumatology, Hospital Marqués de Valdecilla-IDIVAL, University of Cantabria, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
Enar
E
Pons
Division of Rheumatology, Hospital Marqués de Valdecilla-IDIVAL, University of Cantabria, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
Patricia
P
Fuentevilla
Department of Pathology, Hospital Marqués de Valdecilla, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
Carmen
C
González-Vela
Division of Rheumatology, Hospital Marqués de Valdecilla-IDIVAL, University of Cantabria, Avenida de Valdecilla, s/n, Santander, 39008 Cantabria, Spain.
Miguel Á
MÁ
González-Gay