A D-Shaped Bileaflet Bioprosthesis which Replicates Physiological Left Ventricular Flow Patterns.
Prior studies have shown that in a healthy heart, there exist a large asymmetric vortex structure that aids in establishing a steady flow field in the left ventricle. However, the implantation of existing artificial heart valves at the mitral position is found to have a negative effect on this physiological flow pattern. In light of this, a novel D-shaped bileaflet porcine bioprosthesis (GD valve) has been designed based on the native geometry mitral valve, with the hypothesis that biomimicry in valve design can restore physiological left ventricle flow patterns after valve implantation. An in-vitro experiment using two dimensional particle velocimetry imaging was carried out to determine the hemodynamic performance of the new bileaflet design and then compared to that of the well-established St. Jude Epic valve which functioned as a control in the experiment. Although both valves were found to have similar Reynolds shear stress and Turbulent Kinetic Energy levels, the novel D-shape valve was found to have lower turbulence intensity and greater mean kinetic energy conservation.
Department of Biomedical Engineering, National University of Singapore, Faculty of Engineering, Block E4, #04-08, 4 Engineering Drive 3, Singapore 117583, Singapore.
Sean Guo-Dong
SG
Tan
Department of Biomedical Engineering, National University of Singapore, Faculty of Engineering, Block E4, #04-08, 4 Engineering Drive 3, Singapore 117583, Singapore.
Sangho
S
Kim
Department of Surgery, National University of Singapore, Yong Loo Lin School of Medicine, Kent Ridge Road, Singapore 119228, Singapore.
Jimmy Kim Fatt
JK
Hon
Department of Biomedical Engineering, National University of Singapore, Faculty of Engineering, Block E4, #04-08, 4 Engineering Drive 3, Singapore 117583, Singapore.
Hwa Liang
HL
Leo
D000818:Animals; D001705:Bioprosthesis; D001783:Blood Flow Velocity / Q000502:physiology; D006350:Heart Valve Prosthesis; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007700:Kinetics; D008943:Mitral Valve / Q000503:physiopathology*; D008955:Models, Cardiovascular; D010496:Pericardium / Q000473:pathology; D011474:Prosthesis Design; D019919:Prosthesis Implantation; D011673:Pulsatile Flow; D033081:Shear Strength; D013314:Stress, Mechanical; D013552:Swine; D016277:Ventricular Function, Left