Outcome in dogs with advanced (stage 3b) anal sac gland carcinoma treated with surgery or hypofractionated radiation therapy.
Stage 3b anal sac gland carcinoma (ASGC) can be life-threatening. A surgical approach is not always possible or may be declined. Dogs with stage 3b ASGC treated with surgery or conformal radiation therapy (RT) with 8 × 3.8 Gy (total dose 30.4 Gy, over 2.5 weeks) were retrospectively evaluated. Patient characteristics, median progression-free interval (PFI) and median survival time (MST) were compared. Twenty-eight dogs were included; 15 underwent surgery, 13 underwent RT. At the time of presentation, 21% showed life-threatening obstipation and 25% showed hypercalcaemia. PFI and MST for surgery cases were 159 days (95% CI: 135-184 days) and 182 days (95% CI: 146-218 days), both significantly lower than for RT cases with 347 days (95% CI: 240-454 days) and 447 days (95% CI: 222-672 days), (P = 0.01, P = 0.019). Surgery as well as RT led to a fast relief of symptoms. PFI and survival of surgical patients were significantly inferior to that of a comparable patient group treated with conformal hypofractionated RT.
Division of Radiation Oncology, Vetsuisse Faculty University of Zurich, Zurich, Switzerland.
V
V
Meier
North Downs Specialist Referrals, Surrey, UK.
G
G
Polton
Centro Oncologico Veterinario, Sasso Marconi, Italy.
S
S
Cancedda
Department of Biostatistics, Epidemiology Biostatistics and Prevention Institute, Faculty of Medicine, University of Zurich, Zurich, Switzerland.
M
M
Roos
Centro Oncologico Veterinario, Sasso Marconi, Italy.
P
P
Laganga
North Downs Specialist Referrals, Surrey, UK.
T
T
Emmerson
Division of Radiation Oncology, Vetsuisse Faculty University of Zurich, Zurich, Switzerland.
C
C
Rohrer Bley
D000694:Anal Gland Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D000695:Anal Sacs / Q000473:pathology / Q000601:surgery; D000818:Animals; D004283:Dog Diseases / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D004285:Dogs; D005260:Female; D008297:Male; D000069473:Radiation Dose Hypofractionation; D016896:Treatment Outcome
dog; oncology; radiation oncology; small animal; surgical oncology