Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients.
The nuclear factor-erythroid 2- (NF-E2-) related factor 2 (Nrf2) is abated and its ability to reduce oxidative stress is impaired in type 2 diabetes and obesity. Thus, the aim of this study was to explore if polymorphisms in Nrf2 and target genes are associated with diabetes and obesity in Mexican mestizo subjects. The rs1800566 of
quinone oxidoreductase 1 (NQO1) gene, rs7211 of thioredoxin interacting protein (TXNIP) gene, rs2071749 of heme oxygenase-1 (HMOX1) gene, and the rs6721961 and the rs2364723 from Nrf2 gene were genotyped in 627 diabetic subjects and 1020 controls. The results showed that the rs7211 polymorphism is a protective factor against obesity in nondiabetic subjects (CC + CT versus TT, OR = 0.40, P = 0.005) and in women (CC versus CT + TT, OR = 0.7, P = 0.016). TT carriers had lower high-density lipoprotein cholesterol levels and lower body mass index. The rs2071749 was positively associated with obesity (AA versus AG + GG, OR = 1.25, P = 0.026). Finally, the rs6721961 was negatively associated with diabetes in men (CC versus CA + AA, OR = 0.62, P = 0.003). AA carriers showed lower glucose concentrations. No association was found for rs1800566 and rs2364723 polymorphisms. In conclusion, the presence of Nrf2 and related genes polymorphisms are associated with diabetes and obesity in Mexican patients.
Department of Biology, National Autonomous University of Mexico (UNAM), 04510 Mexico City DF, Mexico.
Angélica Saraí
AS
Jiménez-Osorio
Department of Biology, National Autonomous University of Mexico (UNAM), 04510 Mexico City DF, Mexico.
Susana
S
González-Reyes
Department of Biology, National Autonomous University of Mexico (UNAM), 04510 Mexico City DF, Mexico.
Wylly Ramsés
WR
García-Niño
Economy Department, Autonomous Metropolitan University-Iztapalapa, 09340 Mexico City, DF, Mexico.
Hortensia
H
Moreno-Macías
Research Department, Regional Hospital "Lic. Adolfo López Mateos", ISSSTE, 01030 Mexico City, DF, Mexico.
Martha Eunice
ME
Rodríguez-Arellano
Molecular Biology Department, National Institute of Cardiology "Ignacio Chávez", 14080 Mexico City, DF, Mexico.
Gilberto
G
Vargas-Alarcón
Department of Immunology, National Institute of Respiratory Diseases "Ismael Cosío Villegas", 14080 Mexico City, DF, Mexico.
Joaquín
J
Zúñiga
Molecular Genetics Laboratory, National School of Anthropology and History, 14030 Mexico City, DF, Mexico.
Rodrigo
R
Barquera
Department of Biology, National Autonomous University of Mexico (UNAM), 04510 Mexico City DF, Mexico.
José
J
Pedraza-Chaverri
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006442:Glycated Hemoglobin / Q000032:analysis; D051547:Heme Oxygenase-1 / Q000235:genetics*; D006801:Humans; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008297:Male; D008800:Mexico; D008875:Middle Aged; D015999:Multivariate Analysis; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics; D051267:NF-E2-Related Factor 2 / Q000235:genetics*; D009765:Obesity / Q000175:diagnosis / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D018384:Oxidative Stress / Q000235:genetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D065840:Protective Factors; D012307:Risk Factors; D012737:Sex Factors
D015415:Biomarkers; D001786:Blood Glucose; D002352:Carrier Proteins; D006442:Glycated Hemoglobin; D051547:Heme Oxygenase-1; D008055:Lipids; D016660:NAD(P)H Dehydrogenase (Quinone); D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; C486715:TXNIP protein, human; C517652:hemoglobin A1c protein, human; C496541:HMOX1 protein, human; C447479:NQO1 protein, human