Comparative oral dose toxicokinetics of sodium selenite and selenomethionine.
Selenium (Se) poisoning by different forms of Se occurs in the United States. However, the toxicokinetics of different selenocompounds after oral ingestion is not well documented. In this study the toxicokinetics of Se absorption, distribution and elimination were determined in serum and whole blood of lambs that were orally dosed with increasing doses of Se as sodium selenite (inorganic Se) or selenomethionine (SeMet, organic Se). Thirty-two lambs were randomly assigned to eight treatment groups, with four animals per group. Se was administered at 1, 2 or 3 mg kg-1body weight, as either sodium selenite or SeMet with proper control groups. Blood and serum were collected at predetermined time points for 7 days post-dosing. Resulting Se concentrations in both serum and whole blood from SeMet treatment groups were significantly greater than those given equimolar doses of Se as sodium selenite. Se concentrations in serum and whole blood of lambs dosed with SeMet peaked at significantly greater concentrations when compared with lambs dosed with equimolar doses of sodium selenite. Based on the serum and whole blood kinetics, the rate of Se absorption was greater for SeMet than for sodium selenite although rates of absorption for both Se forms decreased with increasing dose. The rates of Se elimination increased with dose. These results demonstrate that SeMet has a greater absorption rate and a similar retention time resulting in a greater area under the curve and thus bioavailability than sodium selenite, which must be considered in both overdose and nutritional exposures. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
United States Department of Agriculture-Agricultural Research Service, Poisonous Plant Research Laboratory, Logan, Utah, USA.
T Zane
TZ
Davis
Amgen Inc., Thousand Oaks, California, USA.
Asheesh K
AK
Tiwary
United States Department of Agriculture-Agricultural Research Service, Poisonous Plant Research Laboratory, Logan, Utah, USA.
Bryan L
BL
Stegelmeier
United States Department of Agriculture-Agricultural Research Service, Poisonous Plant Research Laboratory, Logan, Utah, USA.
James A
JA
Pfister
United States Department of Agriculture-Agricultural Research Service, Poisonous Plant Research Laboratory, Logan, Utah, USA.
Kip E
KE
Panter
Utah State University Veterinary Diagnostic Laboratory, Logan, Utah, USA.
Jeffery O
JO
Hall
D065567:Absorption, Physiological; D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D004305:Dose-Response Relationship, Drug; D012645:Selenomethionine / Q000008:administration & dosage / Q000097:blood* / Q000633:toxicity*; D012756:Sheep; D018038:Sodium Selenite / Q000008:administration & dosage / Q000097:blood* / Q000633:toxicity*; D066007:Toxicokinetics
D012645:Selenomethionine; D018038:Sodium Selenite
Absorption; elimination; selenium; sheep; toxicokinetics