Emerging Roles of Adipose Progenitor Cells in Tissue Development, Homeostasis, Expansion and Thermogenesis.
Stem or progenitor cells are an essential component for the development, homeostasis, expansion, and regeneration of many tissues. Within white adipose tissue (WAT) reside vascular-resident adipose progenitor cells (APCs) that can proliferate and differentiate into either white or beige/brite adipocytes, which may control adiposity. Recent studies have begun to show that APCs can be manipulated to control adiposity and counteract 'diabesity'. However, much remains unknown about the identity of APCs and how they may control adiposity in response to homeostatic and external cues. Here, we discuss recent advances in our understanding of adipose progenitors and cover a range of topics, including the stem cell/progenitor lineage, their niche, their developmental and adult roles, and their role in cold-induced beige/brite adipocyte formation.
Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center 5323, Harry Hines Blvd, Dallas, TX 75235, USA.
Daniel C
DC
Berry
Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center 5323, Harry Hines Blvd, Dallas, TX 75235, USA.
Yuwei
Y
Jiang
Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center 5323, Harry Hines Blvd, Dallas, TX 75235, USA; Department of Molecular Biology, University of Texas Southwestern Medical Center 5323, Harry Hines Blvd, Dallas, TX 75235, USA. Electronic address: jon.graff@utsouthwestern.edu.
Jonathan M
JM
Graff
D000273:Adipose Tissue / Q000166:cytology* / Q000378:metabolism*; D000818:Animals; D006706:Homeostasis / Q000235:genetics / Q000502:physiology; D006801:Humans; D013234:Stem Cells / Q000166:cytology*; D022722:Thermogenesis / Q000235:genetics / Q000502:physiology
adipose tissue; beige/brite adipocytes; niche; obesity; perivascular cells; stem cells