Fluorescence Lifetime Imaging of Cancer In Vivo.
Optical imaging of fluorescent reporters in animal models of cancer has become a common tool in oncologic research. Fluorescent reporters including fluorescent proteins, organic dyes, and inorganic photonic materials are used in fluorescence spectroscopy, microscopy, and whole body preclinical imaging. Fluorescence lifetime imaging provides additional, quantitative information beyond that of conventional fluorescence intensity signals, enabling signal multiplexing, background separation, and biological sensing unique to fluorescent materials.
Department of Radiology, Washington University School of Medicine, Campus Box 8225, 4525 Scott Avenue, St. Louis, MO, 63110, USA.
Owen
O
Peng
Department of Radiology, Washington University School of Medicine, Campus Box 8225, 4525 Scott Avenue, St. Louis, MO, 63110, USA. akersw@mir.wustl.edu.
Walter J
WJ
Akers
D000818:Animals; D045744:Cell Line, Tumor; D005456:Fluorescent Dyes / Q000737:chemistry*; D051379:Mice; D057054:Molecular Imaging / Q000295:instrumentation*; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging*; D061848:Optical Imaging / Q000295:instrumentation; D051598:Whole Body Imaging / Q000295:instrumentation
D005456:Fluorescent Dyes
Animal model; Diffuse spectroscopy; Drug delivery; Microenvironment; Molecular imaging; Oncology; Optical; Preclinical; Time-domain