Brief Report: European Mitochondrial Haplogroups Impact on Liver Fibrosis Progression Among HCV and HIV/HCV-Coinfected Patients From Northwest Spain.
The impact of mitochondrial DNA haplogroups on the outcome of liver fibrosis was evaluated in 362 hepatitis C virus infection (HCV)-monoinfected and HIV/HCV-coinfected patients (147 and 215, respectively) in clinical follow-up at 2 reference hospitals in the Northwest of Spain. The mitochondrial DNA haplogroup H was the most prevalent (50.3%) in this population. The cluster Others and V were recognized as risk factors for the development of liver fibrosis while haplogroup H and HCV genotype 4 confer a lower risk. This information might be useful for prioritization of HCV treatment, especially for F0-F1 patients for whom there is no urgency for treatment.
*Grupo de Virología Clínica, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC) Sergas, Universidade da Coruña (UDC), Spain; †Unidad de Genómica, Grupo de Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC) Sergas, Universidade da Coruña (UDC), Spain; ‡Unidad de Epidemiología Clínica y Bioestadística, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC) Sergas, Universidade da Coruña (UDC), Spain; and §Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Complexo Hospitalario Universitario de Ferrol (CHUF), Sergas, A Coruña, Spain.
Andres
A
Tabernilla
Ignacio
I
Rego-Pérez
Marta
M
Grandal
Berta
B
Pernas
Sonia
S
Pértega
Manuel
M
Delgado
Ana
A
Mariño
Hortensia
H
Álvarez
Alvaro
A
Mena
Iria
I
Rodríguez-Osorio
Jose Domingo
JD
Pedreira
Francisco Javier
FJ
Blanco
Eva
E
Poveda
D000328:Adult; D004272:DNA, Mitochondrial / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006239:Haplotypes; D006526:Hepatitis C / Q000150:complications / Q000473:pathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013030:Spain; D044465:White People / Q000235:genetics*
D004272:DNA, Mitochondrial