Basiliximab induction in kidney transplantation with donation after cardiac death donors.
Basiliximab is a monoclonal antibody that binds to the α-chain of the interleukin (IL)-2 receptor. It is used as induction therapy in kidney transplantation. The objective of the present study was to evaluate induction therapy with single-dose basiliximab (Simulect®) in kidney transplantation with donation after cardiac death (DCD) donors. A total of 33 DCD kidney transplants were performed between December 2010 and July 2013 in patients who received single-dose basiliximab (20 mg) as induction therapy. The maintenance immunosuppression included calcineurin inhibitor (cyclosporine A or tacrolimus), mycophenolate mofetil and corticosteroids. The follow-up time was 1 year. The mean ages of the DCD donors and recipients were 29.3 and 41.1 years, respectively. Within the 1-year follow-up, the overall incidence of acute rejection was 9.1%. There were 10 cases of delayed graft function among the recipients. Mean serum creatinine values at 1 week and at 1, 3, 6, 9 and 12 months post-transplantation were 257.6, 238.2, 194.5, 159.3, 137.9 and 110.8 µmol/l, respectively, with a favorable trend to allograft function recovery over time. The 1-year patient and graft survival rates were 96.9 and 90.9%, respectively, with an infection rate of 24.2%. Increased alanine aminotransferase/aspartate transaminase levels in only 2 patients were considered to be associated with basiliximab. This experience with single-dose basiliximab for induction therapy in DCD kidney transplantation showed that favorable clinical outcomes were achieved in terms of graft survival and function within 1 year.
Department of Renal Transplantation, The Affiliated Urology and Nephrology Hospital, College of Medicine, Ningbo University, Ningbo, Zhejiang 315100, P.R. China.
Xuping
X
Yao
Department of Renal Transplantation, The Affiliated Urology and Nephrology Hospital, College of Medicine, Ningbo University, Ningbo, Zhejiang 315100, P.R. China.
Guobin
G
Weng
Department of Renal Transplantation, The Affiliated Urology and Nephrology Hospital, College of Medicine, Ningbo University, Ningbo, Zhejiang 315100, P.R. China.
Junjun
J
Wei
Department of Renal Transplantation, The Affiliated Urology and Nephrology Hospital, College of Medicine, Ningbo University, Ningbo, Zhejiang 315100, P.R. China.
Wenbo
W
Gao
basiliximab; donation after cardiac death; immunosuppression; kidney; transplantation