Benzimidazole Based 'Turn on' Fluorescent Chemodosimeter for Zinc Ions in Mixed Aqueous Medium.
Benzimidazole based compound 3 is designed and synthesized. The compound 3 is evaluated as fluorogenic sensor for metal ions in mixed aqueous solutions. Among all the metal ions tested, the compound 3 selectively senses Zn(2+) ions. The imine bond of 3 gets cleaved by Zn(2+) ions. Thus, 3 behave as 'turn on' fluorescent chemodosimeter for Zn(2+) ions with limit of detction in micromolar range. Furthurmore, we demonstated that 3 can detect Zn(2+) ions in cells of Allium cepa. Graphical Abstract Benzimidazole based ligand 3 is designed and synthesized which behave as chemodosimeter for Zn(2+) ions. We further demonstrated that 3 can detect Zn(2+) ions in cells of Allium cepa.
School of Basic Sciences, Indian Institute of Technology, Mandi, Himachal Pradesh, 175001, India.
Shilpa
S
Sharma
School of Basic Sciences, Indian Institute of Technology, Mandi, Himachal Pradesh, 175001, India.
Chullikkattil P
CP
Pradeep
School of Basic Sciences, Indian Institute of Technology, Mandi, Himachal Pradesh, 175001, India. abhimanew@iitmandi.ac.in.
Abhimanew
A
Dhir
D001562:Benzimidazoles / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D057054:Molecular Imaging; D019697:Onions / Q000166:cytology / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry*; D015032:Zinc / Q000032:analysis* / Q000737:chemistry* / Q000378:metabolism
D001562:Benzimidazoles; D005456:Fluorescent Dyes; D014867:Water; D015032:Zinc
Chemodosimeter; Confocal study in Allium cepa root tip cells; Turn-on fluorescence sensor; Zinc sensing