Efficient access to alkynylated quinalizinones via the gold(i)-catalyzed aminoalkynylation of alkynes.
The gold-catalyzed aminoalkynylation of alkynes for the synthesis of quinalizinones is reported. For instance, the reaction of pyridinoalkynes with 1-[(triisopropylsilyl)-ethynyl]-1,2-benziodoxol-3(1H)-one (TIPS-EBX) in the presence of a catalytic amount of AuCl at 50 °C afforded alkynylated quinalizinones in 57-87% yields.
Division of Organic Chemistry, CSIR - National Chemical Laboratory, Dr. Homi Bhabha Road, Pune - 411 008, India. n.patil@ncl.res.in and Academy of Scientific and Innovative Research (AcSIR), New Delhi - 110 025, India.
Popat S
PS
Shinde
Division of Organic Chemistry, CSIR - National Chemical Laboratory, Dr. Homi Bhabha Road, Pune - 411 008, India. n.patil@ncl.res.in and Academy of Scientific and Innovative Research (AcSIR), New Delhi - 110 025, India.
Aslam C
AC
Shaikh
Division of Organic Chemistry, CSIR - National Chemical Laboratory, Dr. Homi Bhabha Road, Pune - 411 008, India. n.patil@ncl.res.in and Academy of Scientific and Innovative Research (AcSIR), New Delhi - 110 025, India.
Nitin T
NT
Patil