Biotransformation of Salpichrolides A, C, and G by Three Filamentous Fungi.
Incubation of salpichrolide A (1) with Rhizomucor miehei produced hydroxylation in rings B and C (C-7 and C-12) and led to C-5-C-6 epoxide opening, while incubation of salpichrolides C (2) and G (3) with R. miehei led to epoxide opening at the C-24-C-25 and C-5-C-6 positions, respectively. Biotransformation of salpichrolide A (1) with Cunninghamella elegans produced stereoselective hydroxylated, oxidized, and reduced derivatives in different positions of the A, B, and C rings and C-5-C-6 epoxide opening. In addition, selective epoxide opening at the C-5-C-6 or C-24-C-25 positions was obtained from the incubation of salpichrolide A (1) with Curvularia lunata.
Facultad de Ciencias Químicas, Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Universidad Nacional de Córdoba , Casilla de Correo 495, 5000 Córdoba, Argentina.
Ana V
AV
Basso
Facultad de Ciencias Químicas, Instituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Universidad Nacional de Córdoba , Casilla de Correo 495, 5000 Córdoba, Argentina.
Viviana E
VE
Nicotra
Andrés
A
Parra
Antonio
A
Martínez
Antonia
A
Fernández-Vivas
D001203:Ascomycota; D001711:Biotransformation; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry*; D006900:Hydroxylation; D003904:Mitosporic Fungi; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction
C453519:salpichrolide A; C453502:salpichrolide C; D004875:Ergosterol