Significant reductions in human visual gamma frequency by the gaba reuptake inhibitor tiagabine revealed by robust peak frequency estimation.
The frequency of visual gamma oscillations is determined by both the neuronal excitation-inhibition balance and the time constants of GABAergic processes. The gamma peak frequency has been linked to sensory processing, cognitive function, cortical structure, and may have a genetic contribution. To disentangle the intricate relationship among these factors, accurate and reliable estimates of peak frequency are required. Here, a bootstrapping approach that provides estimates of peak frequency reliability, thereby increasing the robustness of the inferences made on this parameter was developed. The method using both simulated data and real data from two previous pharmacological MEG studies of visual gamma with alcohol and tiagabine was validated. In particular, the study by Muthukumaraswamy et al. [] (Neuropsychopharmacology 38(6):1105-1112), in which GABAergic enhancement by tiagabine had previously demonstrated a null effect on visual gamma oscillations, contrasting with strong evidence from both animal models and very recent human studies was re-evaluated. After improved peak frequency estimation and additional exclusion of unreliably measured data, it was found that the GABA reuptake inhibitor tiagabine did produce, as predicted, a marked decrease in visual gamma oscillation frequency. This result demonstrates the potential impact of objective approaches to data quality control, and provides additional translational evidence for the mechanisms of GABAergic transmission generating gamma oscillations in humans. Hum Brain Mapp 37:3882-3896, 2016. © 2016 Wiley Periodicals, Inc.
Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, CF24 4HQ, United Kingdom. magazzinil@cardiff.ac.uk.
Lorenzo
L
Magazzini
School of Pharmacy, Faculty of Medical and Health Sciences, Auckland University, Auckland, 1123, New Zealand.|School of Psychology, Faculty of Science, Auckland University, Auckland, 1123, New Zealand.
Suresh D
SD
Muthukumaraswamy
Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, CF24 4HQ, United Kingdom.
Anne E
AE
Campbell
The Epilepsy Unit, University Hospital of Wales, Cardiff, CF14 4XW, United Kingdom.
Khalid
K
Hamandi
Division of Brain Sciences, Centre for Neuropsychopharmacology, Imperial College London, W12 0NN, London, United Kingdom.
Anne
A
Lingford-Hughes
Division of Brain Sciences, Centre for Neuropsychopharmacology, Imperial College London, W12 0NN, London, United Kingdom.
Jim F M
JF
Myers
Division of Brain Sciences, Centre for Neuropsychopharmacology, Imperial College London, W12 0NN, London, United Kingdom.
David J
DJ
Nutt
Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, CF24 4HQ, United Kingdom.
Petroc
P
Sumner
Division of Brain Sciences, Centre for Neuropsychopharmacology, Imperial College London, W12 0NN, London, United Kingdom.
Sue J
SJ
Wilson
Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, CF24 4HQ, United Kingdom.
Krish D
KD
Singh
D000428:Alcohol Drinking / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002492:Central Nervous System Depressants / Q000494:pharmacology; D003198:Computer Simulation; D018592:Cross-Over Studies; D000431:Ethanol / Q000494:pharmacology; D058805:GABA Uptake Inhibitors / Q000494:pharmacology*; D065818:Gamma Rhythm / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography; D008959:Models, Neurological; D009557:Nipecotic Acids / Q000494:pharmacology*; D016037:Single-Blind Method; D000078308:Tiagabine; D014796:Visual Perception / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid
D002492:Central Nervous System Depressants; D058805:GABA Uptake Inhibitors; D009557:Nipecotic Acids; D000431:Ethanol; D005680:gamma-Aminobutyric Acid; D000078308:Tiagabine
GABA; bootstrapping; gamma oscillations; magnetoencephalography; peak frequency; tiagabine