Systemic saturated lysophosphatidylcholine is associated with hepatic function in patients with liver cirrhosis.
Serum lysophosphatidylcholine (LPC) is described to decline in patients with chronic liver diseases. Here it was evaluated which of the LPC species are associated with liver function. LPC species were quantified by direct flow-injection electrospray ionization tandem mass spectrometry in serum of 45 patients with mainly alcoholic liver cirrhosis. Saturated LPC is 52.1 (31.7-110.0) μmol/l in serum of patients with CHILD-PUGH score C (decompensated liver cirrhosis) and significantly lower compared to patients with well-compensated disease (CHILD-PUGH score A) with 114.1 (12.3-401.4) μmol/l. Mono- and polyunsaturated LPC are not changed in these groups. Saturated LPC is negatively correlated with the model for end-stage liver disease score, bilirubin and galectin-3 and positively with Quick prothrombin time. Ascites and varices are complications of liver cirrhosis. Saturated LPC does, however, not correlate with hepatic venous pressure gradient, ascites volume and variceal size. Unexpectedly, saturated LPC measured in serum of 42 patients declines from 88.4 (27.8-177.5) μmol/l to 72.4 (27.6-141.8) μmol/l shortly after transjugular intrahepatic portosystemic shunt implantation. Hepatic vein saturated LPC (82.3 (12.4-161.7) μmol/l) is higher than portal vein levels (78.8 (10.1-161.0) μmol/l) suggesting hepatic release of this lipid species. Current data demonstrate that systemic saturated LPC species are reduced in patients with decompensated liver cirrhosis and associated with mortality risk.
Department of Internal Medicine I, Regensburg University Hospital, D-93042 Regensburg, Germany; Institute for Clinical Chemistry and Laboratory Medicine, Regensburg University Hospital, Regensburg, Germany.
Sabrina
S
Krautbauer
Department of Internal Medicine I, Regensburg University Hospital, D-93042 Regensburg, Germany.
Kristina
K
Eisinger
Department of Visceral Surgery and Medicine, University Inselspital, Bern, Switzerland.
Reiner
R
Wiest
Institute for Clinical Chemistry and Laboratory Medicine, Regensburg University Hospital, Regensburg, Germany.
Gerhard
G
Liebisch
Department of Internal Medicine I, Regensburg University Hospital, D-93042 Regensburg, Germany. Electronic address: christa.buechler@klinik.uni-regensburg.de.
Christa
C
Buechler
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001201:Ascites / Q000097:blood* / Q000150:complications / Q000473:pathology; D001798:Blood Proteins; D005260:Female; D037502:Galectin 3 / Q000097:blood; D037161:Galectins; D006503:Hepatic Veins; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood* / Q000150:complications / Q000473:pathology; D008244:Lysophosphatidylcholines / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time; D012720:Severity of Illness Index
D001798:Blood Proteins; D037502:Galectin 3; D037161:Galectins; C428445:LGALS3 protein, human; D008244:Lysophosphatidylcholines
Ascites; CHILD-PUGH score; Galectin-3; Phosphatidylcholine