Epidemiological Characteristics of Dementia Treatment in Croatia.
BACKGROUND
In spite of the increase in the number of patients with dementia in countries with older population, basic epidemiologic data are still scarce. The objective of this paper is to investigate pharmacoepidemiological characteristics of treatment of dementia in Croatia, and to present them in the context of certain epidemiological characteristics that illustrate the growing pressure this disease exerts on the healthcare system.


METHODS
Data on medication utilization were taken from Croatian Health Insurance Fund (HZZO) and Agency for Medicinal Products and Medical Devices of Croatia (HALMED). Data on the number of hospital stays were supplied by Croatian Institute of Public Health (HZJZ). Internal data on the number of outpatient examinations from the Clinical hospital "Sveti Duh" were used as well.


RESULTS
In the observed period (2012-2014), 4568 patients were treated with anti-dementia medications, of which 1275 (32%) with donepezil, and 2753 (68%) with memantine. According to HALMED, the utilization of those medications is constantly increasing, and has increased manifold from 2005 to 2014. The estimate of the proportion of treated patients with dementia aged 60 years and over is around 9.2%. The number of dementia-related hospital stays is also increasing, and has increased by 9.6% in the last 5-year period, compared to the preceding 5-year period. The number of outpatient examinations in Clinical Hospital "Sveti Duh" grew from 351 in 2007 to 1151 in 2015 (January 1(st) - October 26(th)).


CONCLUSIONS
The strain this condition exerts on the healthcare system is increasing yearly. In spite of the large increase in the medication utilization over the previous years, the proportion of treated patients is still small, and further increase in their use is to be expected. It is necessary to monitor this in the years ahead.
Department of Neurology, Clinical Hospital "Sveti Duh", Sveti Duh 64, 10 000 Zagreb, Croatia, stomasovic98@gmail.com.
Sanja
S
Tomasović
Josip
J
Sremec
Jelena
J
Košćak
Nataša
N
Klepac
Pero
P
Draganić
Ivan
I
Bielen
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017523:Croatia; D016208:Databases, Factual; D003704:Dementia / Q000188:drug therapy*; D000077265:Donepezil; D015259:Dopamine Agents / Q000627:therapeutic use*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D008297:Male; D008559:Memantine / Q000627:therapeutic use*; D008875:Middle Aged; D018697:Nootropic Agents / Q000627:therapeutic use*; D017891:Pharmacoepidemiology; D010880:Piperidines / Q000627:therapeutic use*; D055815:Young Adult
D015259:Dopamine Agents; D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D000077265:Donepezil; D008559:Memantine