Cation Exchange Strategy for the Encapsulation of a Photoactive CO-Releasing Organometallic Molecule into Anionic Porous Frameworks.
The encapsulation of the photoactive, nontoxic, water-soluble, and air-stable cationic CORM [Mn(tacn)(CO)3]Br (tacn = 1,4,7-triazacyclononane) in different inorganic porous matrixes, namely, the metalorganic framework bio-MOF-1, (NH2(CH3)2)2[Zn8(adeninate)4(BPDC)6]·8DMF·11H2O (BPDC = 4,4'-biphenyldicarboxylate), and the functionalized mesoporous silicas MCM-41-SO3H and SBA-15-SO3H, is achieved by a cation exchange strategy. The CO release from these loaded materials, under simulated physiological conditions, is triggered by visible light. The results show that the silica matrixes, which are unaltered under physiological conditions, slow the kinetics of CO release, allowing a more controlled CO supply. In contrast, bio-MOF-1 instability leads to the complete leaching of the CORM. Nevertheless, the degradation of the MOF matrix gives rise to an enhanced CO release rate, which is related to the presence of free adenine in the solution.
Department of Inorganic Chemistry, University of Granada , Av. Fuentenueva S/N, 18071 Granada, Spain.
Francisco J
FJ
Carmona
Department of Inorganic Chemistry, University of Granada , Av. Fuentenueva S/N, 18071 Granada, Spain.
Sara
S
Rojas
Department of Inorganic Chemistry, University of Granada , Av. Fuentenueva S/N, 18071 Granada, Spain.
Purificación
P
Sánchez
Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa , Av. da República, EAN, 2780-157 Oeiras, Portugal.
Hélia
H
Jeremias
Alfama Ltd. , Instituto de Biologia Experimental e Tecnológica, IBET, Av. da República, EAN, 2780-157 Oeiras, Portugal.
Ana R
AR
Marques
Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa , Av. da República, EAN, 2780-157 Oeiras, Portugal.|Alfama Ltd. , Instituto de Biologia Experimental e Tecnológica, IBET, Av. da República, EAN, 2780-157 Oeiras, Portugal.
Carlos C
CC
Romão
Laboratorio de Estudios Cristalográficos, IACT-CSIC , Av. de las Palmeras, 4, 18100 Armilla, Granada, Spain.
Duane
D
Choquesillo-Lazarte
Department of Inorganic Chemistry, University of Granada , Av. Fuentenueva S/N, 18071 Granada, Spain.
Jorge A R
JA
Navarro
Department of Inorganic Chemistry, University of Granada , Av. Fuentenueva S/N, 18071 Granada, Spain.
Carmen R
CR
Maldonado
Department of Inorganic Chemistry, University of Granada , Av. Fuentenueva S/N, 18071 Granada, Spain.
Elisa
E
Barea