Topographical representation of odor hedonics in the olfactory bulb.
Hedonic value is a dominant aspect of olfactory perception. Using optogenetic manipulation in freely behaving mice paired with immediate early gene mapping, we demonstrate that hedonic information is represented along the antero-posterior axis of the ventral olfactory bulb. Using this representation, we show that the degree of attractiveness of odors can be bidirectionally modulated by local manipulation of the olfactory bulb's neural networks in freely behaving mice.
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Centre, Neuroplasticity and Neuropathology of Olfactory Perception Team, University Lyon 1, University of Lyon, Lyon, France.|Current address: Kavli Institute for Systems Neuroscience, Centre for Neural Computation, The Faculty of Medicine, NTNU, Trondheim, Norway.
Florence
F
Kermen
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Centre, Neuroplasticity and Neuropathology of Olfactory Perception Team, University Lyon 1, University of Lyon, Lyon, France.
Maëllie
M
Midroit
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Centre, Neuroplasticity and Neuropathology of Olfactory Perception Team, University Lyon 1, University of Lyon, Lyon, France.
Nicola
N
Kuczewski
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Centre, Neuroplasticity and Neuropathology of Olfactory Perception Team, University Lyon 1, University of Lyon, Lyon, France.
Jérémy
J
Forest
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Centre, Neuroplasticity and Neuropathology of Olfactory Perception Team, University Lyon 1, University of Lyon, Lyon, France.
Marc
M
Thévenet
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Centre, Neuroplasticity and Neuropathology of Olfactory Perception Team, University Lyon 1, University of Lyon, Lyon, France.
Joëlle
J
Sacquet
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Neurogenetic and Optogenetic Platform, University Lyon 1, University of Lyon, Lyon, France.
Claire
C
Benetollo
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Centre, Neuroplasticity and Neuropathology of Olfactory Perception Team, University Lyon 1, University of Lyon, Lyon, France.
Marion
M
Richard
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Centre, Neuroplasticity and Neuropathology of Olfactory Perception Team, University Lyon 1, University of Lyon, Lyon, France.
Anne
A
Didier
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Centre, Neuroplasticity and Neuropathology of Olfactory Perception Team, University Lyon 1, University of Lyon, Lyon, France.
Nathalie
N
Mandairon
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D008297:Male; D008810:Mice, Inbred C57BL; D009415:Nerve Net / Q000502:physiology*; D009812:Odorants / Q000032:analysis; D009830:Olfactory Bulb / Q000502:physiology*; D055696:Olfactory Perception / Q000502:physiology*; D012903:Smell / Q000502:physiology*