Nontuberculous mycobacteria in cystic fibrosis patients on the Island of Gran Canaria. A population study.
OBJECTIVE
To determine the prevalence of nontuberculous mycobacteria (NTM) colonization and disease in cystic fibrosis (CF) patients.


METHODS
All the CF patients followed-up from 2002 to 2012 with three acid-fast bacilli (AFB) cultures were included. The American Thoracic Society (ATS) criteria for NTM lung disease were applied.


RESULTS
Forty-four of the 53 patients being followed-up were included. The mean time of follow-up was 7.0 years. A total of 18 patients (40.9%) were NTM positive. The NTN mean annual prevalence was 14.1%. The risk of Mycobacterium abscessus complex was higher in the group of 10-14 years-old (p < 0.001). Ten patients (22.7% of the entire cohort) met the ATS microbiological criteria. The mean annual prevalence of NTM disease was 10.4%. Seven patients (four with Mycobacterium simiae and three with M. abscessus complex) with multiple positive cultures, positive AFB smears and clinical worsening were treated. Three patients with M. simiae and none of those with M. abscessus were cured.


CONCLUSIONS
Overall NTM prevalence of colonization and disease were high in our CF patients. Patients <15 years old had a higher risk of M. abscessus complex colonization. Multiple positive cultures or positive AFB smears were associated with disease.
Microbiology Department, Hospital Universitario de Gran Canaria Doctor Negrín, Barranco de la Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain. Electronic address: mcamnavl@gobiernodecanarias.org.
M Isolina
MI
Campos-Herrero
Microbiology Department, Hospital Universitario de Gran Canaria Doctor Negrín, Barranco de la Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain. Electronic address: fc.chamizo@gmail.com.
Francisco Javier
FJ
Chamizo
Pneumology Department, Hospital Universitario de Gran Canaria Doctor Negrín, Barranco de la Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain. Electronic address: jcamlun@gobiernodecanarias.org.
José Antonio
JA
Caminero
Microbiology Department, Hospital Universitario de Gran Canaria Doctor Negrín, Barranco de la Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain. Electronic address: raul.gilarranz@gmail.com.
Raúl
R
Gilarranz
Pediatrics Department, Complejo Hospitalario Universitario Insular Materno-Infantil, Av Marítima Sur s/n, 35001, Las Palmas de Gran Canaria, Spain. Electronic address: gcabroc@gobiernodecanarias.org.
Gonzalo
G
Cabrera
Pneumology Department, Hospital Universitario de Gran Canaria Doctor Negrín, Barranco de la Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain. Electronic address: jcuydom@gobiernodecanarias.org.
José
J
Cuyás
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000453:epidemiology* / Q000382:microbiology*; D009170:Nontuberculous Mycobacteria / Q000302:isolation & purification*; D015995:Prevalence; D055815:Young Adult
Colonization; Cystic fibrosis; Disease, Mycobacterium abscessus complex; Mycobacterium simiae; Nontuberculous mycobacteria; Prevalence