CD30-Positive Anaplastic Lymphoma Kinase-Negative Systemic Anaplastic Large-Cell Lymphoma in a 9-Year-Old Boy.
Anaplastic large-cell lymphoma (ALCL) is a CD30-positive T-cell/null-cell lymphoma that is clinically classified into either primary cutaneous ALCL or systemic ALCL (S-ALCL) sub-types. Because 90% of childhood S-ALCL cases are anaplastic lymphoma kinase (ALK)-positive, there is a lack of data on ALK-negative S-ALCL cases among pediatric patients. Herein, we report a rare case of ALK-negative S-ALCL in a 9-year-old Korean boy who initially presented with itchy erythematous maculopapules and an erosive nodule on the trunk area. We emphasize the need of high index of suspicion of an underlying malignant disease in the presence of refractory eczematous lesions.
Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.
Jeong Eun
JE
Kim
Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.
Eui Hyun
EH
Oh
Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.
Young Suck
YS
Ro
Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.
Joo Yeon
JY
Ko
Anaplastic large-cell lymphoma; Anaplastic lymphoma kinase; Eczema