Safety of concurrent treatment of cats with fluralaner and emodepsid-praziquantel.
Fluralaner is a novel systemic ectoparasiticide for cats providing immediate and persistent flea- and tick-control after a single topical dose. Emodepsid and praziquantel are routinely used to control intestinal worm infections in cats. The safety of concurrent use of fluralaner and a commercially available emodepsid-praziquantel combination topical solution was investigated using topical administrations at the maximum recommended dose rates.



Few mild and transient clinical findings like erythema at the administration site and single incidences of salivation or vomiting were observed. All of which were consistent with the individual product leaflets. There were no findings suggesting an increased safety risk associated with the concurrent treatment of cats with fluralaner and emodepsid-praziquantel.



Concurrent treatment with fluralaner, emodepsid and praziquantel is well tolerated in cats.
Merck Animal Health, 2 Giralda Farms, Madison, NJ, USA. feli.walther@merck.com.
Feli M
FM
Walther
MSD Animal Health Innovation GmbH, Zur Propstei, 55270, Schwabenheim, Germany.
Mark J
MJ
Allan
MSD Animal Health Innovation GmbH, Zur Propstei, 55270, Schwabenheim, Germany.
Rainer K A
RK
Roepke
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D002371:Cat Diseases / Q000188:drug therapy* / Q000469:parasitology; D002415:Cats; D047630:Depsipeptides / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D003877:Dermatitis, Contact / Q000662:veterinary; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004478:Ectoparasitic Infestations / Q000188:drug therapy / Q000662:veterinary; D004890:Erythema / Q000139:chemically induced / Q000662:veterinary; D005260:Female; D007306:Insecticides / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary; D007555:Isoxazoles / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D008297:Male; D011223:Praziquantel / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D012472:Salivation / Q000187:drug effects
C000591860:A1443 compound; D000871:Anthelmintics; D047630:Depsipeptides; D007306:Insecticides; D007555:Isoxazoles; D011223:Praziquantel; C468987:emodepside
Bravecto™; Cat; Emodepsid; Fluralaner; Praziquantel; Profender™; Safety