Generation of Lung and Airway Epithelial Cells from Embryonic Stem Cells In Vitro.
The epithelium covers the internal surface of the lung airways and is composed of numerous cell types that arise from the anterior foregut endoderm. The ability to generate pulmonary cells from embryonic stem cells will allow study of lung development, drug screening, regenerative medicine, and modeling of lung diseases. The aim of this review is to describe the methods used to produce lung cells in vitro, based on mechanisms of lung development in during embryology.
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Institute of Biomedical Research, University of Tehran, Tehran, Iran.
Sirous
S
Sadeghian Chaleshtori
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Institute of Biomedical Research, University of Tehran, Tehran, Iran.
Mohammad Reza Mokhber
MR
Dezfouli
Institute of Biomedical Research, University of Tehran, Tehran, Iran; Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Mohammad Mehdi
MM
Dehghan
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Institute of Biomedical Research, University of Tehran, Tehran, Iran.
Hamid
H
Tavanaeimanesh
D000818:Animals; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000502:physiology*; D004847:Epithelial Cells; D006801:Humans; D066298:In Vitro Techniques / Q000379:methods*; D012137:Respiratory System