Complex Polarity: Building Multicellular Tissues Through Apical Membrane Traffic.
The formation of distinct subdomains of the cell surface is crucial for multicellular organism development. The most striking example of this is apical-basal polarization. What is much less appreciated is that underpinning an asymmetric cell surface is an equally dramatic intracellular endosome rearrangement. Here, we review the interplay between classical cell polarity proteins and membrane trafficking pathways, and discuss how this marriage gives rise to cell polarization. We focus on those mechanisms that regulate apical polarization, as this is providing a number of insights into how membrane traffic and polarity are regulated at the tissue level.
Cancer Research UK Beatson Institute, Switchback Road, Glasgow, G61 1BD, UK.|Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
Alvaro
A
Román-Fernández
Cancer Research UK Beatson Institute, Switchback Road, Glasgow, G61 1BD, UK.|Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
David M
0000-0003-2721-5012
DM
Bryant
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D016764:Cell Polarity / Q000502:physiology*; D004705:Endocytosis / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D009024:Morphogenesis; D021381:Protein Transport; D012795:Sialoglycoproteins / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000378:metabolism
D008565:Membrane Proteins; D012795:Sialoglycoproteins; C001643:podocalyxin; D020691:rab GTP-Binding Proteins
3D culture; Crumbs; Podocalyxin; Rab GTPases; apical transport; cell polarity; endocytosis; epithelia; exocytosis; lumen formation; morphogenesis; trafficking