Hydroethanolic extract of Smallanthus sonchifolius leaves improves hyperglycemia of streptozotocin induced neonatal diabetic rats.
OBJECTIVE
To evaluate the effect of hydroethanolic extract of yacon on the hyperglycemia induced by streptozotocin (STZ) in neonatal rats.


METHODS
Wistar rats aged two days old received an intraperitoneal injection of STZ (160 mg/kg); after seven weeks, glycosuria was determined and animals with glucose levels above 250 mg/dL were included in the study. Groups of diabetic and non-diabetic rats were treated orally with yacon extract at a dose of 400 mg/kg/d for 14 d. Tests were made for phytochemical characterization, glucose tolerance and toxicity.


RESULTS
The results showed that treatment with the extract reduced the glucose levels of fed diabetic rats and did not change the glucose levels of fasting diabetic and normal rats. Additionally, also it was observed that treatment with the extract reduced blood glucose levels of diabetic rats during the oral and intravenous glucose tolerance tests. There was no change in body weight, liver enzymes or mortality with yacon extract treatment. The phytochemical screening revealed the presence of caffeic acid, chlorogenic acid, ferulic acid and gallic acid.


CONCLUSIONS
The data suggest that yacon extract reduces hyperglycemia, possibly by improving insulin sensibility through its phytochemicals constituents (phenolic compounds).
Department of Pharmacology and Therapeutic, State University of Maringá, Paraná, Brazil.
Silmara
S
Baroni
Department of Pharmacology and Therapeutic, State University of Maringá, Paraná, Brazil.
Bruno Ambrosio
BA
da Rocha
Department of Pharmacology and Therapeutic, State University of Maringá, Paraná, Brazil.
Juliana
J
Oliveira de Melo
Department of Biochemistry, State University of Maringá, Paraná, Brazil.
Jurandir Fernando
JF
Comar
Department of Pharmacology and Therapeutic, State University of Maringá, Paraná, Brazil.
Silvana Martins
SM
Caparroz-Assef
Department of Pharmacology and Therapeutic, State University of Maringá, Paraná, Brazil. Electronic address: cabamado@uem.br.
Ciomar Aparecida
CA
Bersani-Amado
Hyperglycemia; Insulin sensibility; Streptozotocin; Yacon extract