Treatment of lip florid papillomatosis with topical ALA-PDT combined with curettage: Outcome and safety.
BACKGROUND
Photodynamic therapy (PDT) is a successful treatment in clinical practice. PDT is increasingly used to cure the patients with skin cancer, especially in the elder. The purpose of this study was to evaluate the treatment outcome and safety of PDT with aminolevulinic acid (5-ALA) combined with surgical curettage for lip florid papillomatosis.


METHODS
In this study, 4 cases of lip florid papillomatosis were treated with topical aminolevulinic acid photodynamic therapy (ALA-PDT) combined with curettage. First, the warts were removed with the patient under local anesthesia. The depth of the ablation and curettage reached the dermal layer. Then, the first session of PDT was performed after 2days. Ten percent 5-ALA cream was applied to lesional skin with occlusive dressing for a 3-h incubation period and the lesions of warts were irradiated for 10min by using a 635-nm laser beam of 177mW/cm2 intensity. The ALA-PDT was repeated after 1 and 3 weeks and two other treatments applied if necessary. Follow-up evaluation was performed at our outpatient clinic at 3 and 6 months after completion of therapy.


RESULTS
After three PDT sessions following surgical curettage, 3 patients were cured at 3 months off treatment, one cases relapsed, corresponding to a recurrent rate of 25%. There was no other recurrence at 6 months off treatment. The satisfaction rate of patients was 95% at 3 month and 100% at 6 months after treatment.


CONCLUSIONS
The combined treatment of topical ALA-PDT and curettage was proven to be safe and effective in lip florid papillomatosis.
Department of Plastic & Cosmetic Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, PR China. Electronic address: docgaoyang@126.com.
Yang
Y
Gao
Department of Plastic & Cosmetic Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, PR China. Electronic address: hl_wang@Foxmail.com.
Hai-Lin
HL
Wang
Department of Plastic & Cosmetic Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, PR China. Electronic address: ws_dream@126.com.
Wen-Sheng
WS
Wang
Department of Plastic & Cosmetic Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, PR China. Electronic address: 55227819@qq.com.
Jia
J
Liu
Department of Plastic & Cosmetic Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, PR China. Electronic address: skin515@163.com.
Yuan-Gang
YG
Lu
D000287:Administration, Topical; D000328:Adult; D000622:Aminolevulinic Acid / Q000008:administration & dosage*; D003131:Combined Modality Therapy / Q000379:methods; D003475:Curettage / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004359:Drug Therapy, Combination / Q000379:methods; D006801:Humans; D008027:Light; D008048:Lip Neoplasms / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy*; D008137:Longitudinal Studies; D008297:Male; D010212:Papilloma / Q000175:diagnosis / Q000628:therapy*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D012008:Recurrence; D016896:Treatment Outcome
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid
Aminolevulinic acid; Curettage; Lip florid papillomatosis; Therapy; Topical photodynamic therapy