Phenolic Derivatives from the Root Bark ofOplopanax horridus.
Four new phenolic derivatives, including two phenylpropanoid glycosides, one benzoate glycoside, and one lignan glycoside, together with one known glyceride, were isolated from the root bark ofOplopanax horridus. The structures of the new compounds were elucidated as 3-{4-[(6-O-acetyl-β-D-glucopyranosyl) oxy]-3,5-dimethoxyphenylpropanoic acid (1), (+)-[5,6,7,8-tetrahydro-7- (hydroxylmethyl)-10,11-dimehoxydibenzo[a,c][8]annulen-6-yl]methylβ-D-glucopyranoside (2), (+)-methyl 4-[6-O-{3-hydroxy-3-methyl-5-(1-methylpropyl)oxy]-5-oxopentanoyl}-4-O-(β-D-glucopyranosyl)-β-D-glucopyranosyl)oxy]-3-methoxybenzoate (3), and 2-methoxy-4-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl 6-O-{3-hydroxy-3-methyl-5-[(1-methylpropyl)oxy]-5-oxopentanoyl-4-O-β-D-glucopyranosyl-β-D-glucopyranoside (4) on the basis of spectroscopic techniques including NMR and MS analyses. The known compound was identified as glycer-2-yl ferulate (5) by comparing its physical and spectral data with those reported in the literature.
State key laboratory for quality research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau; Macao SAR, P. R. China, phone: +853-8397-4692; fax: +853-2884-1358; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China.
Wei-Hua
WH
Huang
State key laboratory for quality research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau; Macao SAR, P. R. China, phone: +853-8397-4692; fax: +853-2884-1358.
Qing-Wen
QW
Zhang
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago; 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, USA, phone: +1 773 702 1916; fax: +1 773 834 0601.
Chong-Zhi
CZ
Wang
Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago; 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, USA, phone: +1 773 702 1916; fax: +1 773 834 0601.
Chun-Su
CS
Yuan
State key laboratory for quality research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau; Macao SAR, P. R. China, phone: +853-8397-4692; fax: +853-2884-1358.
Shao-Ping
SP
Li
Oplopanax; Oplopanax horridus; lignan; phenylpropanoid