Iminium Catalysis inside a Self-Assembled Supramolecular Capsule: Modulation of Enantiomeric Excess.
The noncovalent combination of a supramolecular host with iminium organocatalysis is described. Due to cation-π interactions the reactive iminium species is held inside the host and reacts in this confined environment. The products formed differ up to 92 % ee from the control experiments without added host. A model rationalizing the observed difference is presented.
Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85747, Garching, Germany.
Thomas M
TM
Bräuer
Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85747, Garching, Germany.
Qi
Q
Zhang
Department of Chemistry, University of Basel, St. Johannsring 19, CH-4056, Basel, Switzerland. konrad.tiefenbacher@unibas.ch.
Konrad
0000-0002-3351-6121
K
Tiefenbacher
enantioselectivity; host-guest systems; iminium catalysis; organocatalysis; supramolecular chemistry