Elevated expression of RNA methyltransferase BCDIN3D predicts poor prognosis in breast cancer.
BACKGROUND
BCDIN3D is a member of the Bin3 methyl-transferase family that targets the 5' mono-phosphate of nucleic acids. Although BCDIN3D has been shown to increase tumorigenic phenotypes and invasiveness in MDA-MB-231 cells, its the clinical implications in breast cancer remain unclear.


METHODS
We screened for BCDIN3D using tissue microarrays constructed from 250 patients who were histologically confirmed to have invasive ductal breast carcinoma at the Fudan University Shanghai Cancer Center.


RESULTS
The survival analysis by Kaplan-Meier and Cox regression showed that BCDIN3D expression level served as a prognostic factor for disease-free survival (P = 0.042). The prognostic value of BCDIN3D was most significant in triple-negative breast cancer (TNBC) patients (P = 0.007).


CONCLUSIONS
BCDIN3D might serve as an important prognostic factor for TNBC patients.
Department of Breast Surgery, Fudan University, Shanghai Cancer Center and Cancer Institute, Shanghai, P.R. China.
Ling
L
Yao
Department of Breast Surgery, Fudan University, Shanghai Cancer Center and Cancer Institute, Shanghai, P.R. China.
Yayun
Y
Chi
Department of Breast Surgery, Fudan University, Shanghai Cancer Center and Cancer Institute, Shanghai, P.R. China.
Xin
X
Hu
Department of Breast Surgery, Fudan University, Shanghai Cancer Center and Cancer Institute, Shanghai, P.R. China.
Shan
S
Li
Department of Breast Surgery, Fudan University, Shanghai Cancer Center and Cancer Institute, Shanghai, P.R. China.
Feng
F
Qiao
Department of Breast Surgery, Fudan University, Shanghai Cancer Center and Cancer Institute, Shanghai, P.R. China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, P.R. China.|Institutes of Biomedical Science, Fudan University, Shanghai, P.R. China.
Jong
J
Wu
Department of Breast Surgery, Fudan University, Shanghai Cancer Center and Cancer Institute, Shanghai, P.R. China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, P.R. China.|Institutes of Biomedical Science, Fudan University, Shanghai, P.R. China.
Zhi-Ming
ZM
Shao
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008780:Methyltransferases / Q000032:analysis / Q000096:biosynthesis*; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D064726:Triple Negative Breast Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*
D014408:Biomarkers, Tumor; C000622632:BCDIN3D protein, human; D008780:Methyltransferases
BCDIN3D; TNBC; breast cancer