Hepatic Gadolinium Deposition and Reversibility after Contrast Agent-enhanced MR Imaging of Pediatric Hematopoietic Stem Cell Transplant Recipients.
Purpose To determine if hepatic gadolinium deposition occurs in pediatric patients with iron overload but normal renal and hepatic function who undergo gadolinium-based contrast agent (GBCA)-enhanced magnetic resonance (MR) imaging. Materials and Methods Design and execution of this study was approved by the Ethical Committee of Institute for Research in Maternal and Child Health Burlo Garofolo of Trieste (reference no. 1105/2015). Because of the retrospective nature of the study, the requirement to obtain informed consent was waived. Twenty-one recipients of allogeneic hematopoietic stem cell transplants who underwent GBCA-enhanced MR imaging for suspected infection or relapse followed by liver biopsy comprised the study group. The number of GBCA-enhanced MR examinations and cumulative gadolinium dose for each patient was analyzed by comparing liver histologic analysis and iron and gadolinium liver concentration (GLC). Eight patients had siderosis and underwent chelation therapy. The study group was compared with four control patients who were never exposed to GBCA. Statistical analysis was performed with Spearman rank coefficient for correlation. Results All 21 patients had positive correlations between GLC and total GBCA dose (r = 0.4486; P < .05) and between GLC and liver iron concentration (r = 0.56; P < .05). Patients who underwent deferoxamine therapy had a significant reduction of GLC (from 0.64 μg/g ± 0.29 to 0.20 μg/g ± 0.17 [standard deviation]; P < .05). Conclusion In the presence of siderosis, a transmetallation mechanism may be set off between ferric ion and gadoterate meglumine. Deferoxamine appears capable of binding to gadolinium ion. Further studies of the safety of GBCAs in severe siderosis are needed. Chelation should be considered in patients with iron overload and a history of GBCA exposure.©RSNA, 2016.
From the Bone Marrow Transplant Unit (N.M.), Department of Radiology (M.G., F.Z.), Department of Transfusion Medicine (R.S.), and Department of Pharmacy (D.Z.), Institute for Maternal and Child Health-IRCCS Burlo Garofolo, via dell'Istria, 65/1, 34137 Trieste, Italy; and Department of Pathology, Ospedale Beato Papa Giovanni XXIII, Bergamo, Italy (A.S.).
Natalia
N
Maximova
From the Bone Marrow Transplant Unit (N.M.), Department of Radiology (M.G., F.Z.), Department of Transfusion Medicine (R.S.), and Department of Pharmacy (D.Z.), Institute for Maternal and Child Health-IRCCS Burlo Garofolo, via dell'Istria, 65/1, 34137 Trieste, Italy; and Department of Pathology, Ospedale Beato Papa Giovanni XXIII, Bergamo, Italy (A.S.).
Massimo
M
Gregori
From the Bone Marrow Transplant Unit (N.M.), Department of Radiology (M.G., F.Z.), Department of Transfusion Medicine (R.S.), and Department of Pharmacy (D.Z.), Institute for Maternal and Child Health-IRCCS Burlo Garofolo, via dell'Istria, 65/1, 34137 Trieste, Italy; and Department of Pathology, Ospedale Beato Papa Giovanni XXIII, Bergamo, Italy (A.S.).
Floriana
F
Zennaro
From the Bone Marrow Transplant Unit (N.M.), Department of Radiology (M.G., F.Z.), Department of Transfusion Medicine (R.S.), and Department of Pharmacy (D.Z.), Institute for Maternal and Child Health-IRCCS Burlo Garofolo, via dell'Istria, 65/1, 34137 Trieste, Italy; and Department of Pathology, Ospedale Beato Papa Giovanni XXIII, Bergamo, Italy (A.S.).
Aurelio
A
Sonzogni
From the Bone Marrow Transplant Unit (N.M.), Department of Radiology (M.G., F.Z.), Department of Transfusion Medicine (R.S.), and Department of Pharmacy (D.Z.), Institute for Maternal and Child Health-IRCCS Burlo Garofolo, via dell'Istria, 65/1, 34137 Trieste, Italy; and Department of Pathology, Ospedale Beato Papa Giovanni XXIII, Bergamo, Italy (A.S.).
Roberto
R
Simeone
From the Bone Marrow Transplant Unit (N.M.), Department of Radiology (M.G., F.Z.), Department of Transfusion Medicine (R.S.), and Department of Pharmacy (D.Z.), Institute for Maternal and Child Health-IRCCS Burlo Garofolo, via dell'Istria, 65/1, 34137 Trieste, Italy; and Department of Pathology, Ospedale Beato Papa Giovanni XXIII, Bergamo, Italy (A.S.).
Davide
D
Zanon
D002648:Child; D019786:Gadolinium DTPA / Q000494:pharmacology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D019190:Iron Overload / Q000000981:diagnostic imaging*; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012189:Retrospective Studies
D019786:Gadolinium DTPA