PDCD1 PD-1.3 polymorphism and allergic bronchial asthma in Russian and Buryat patients.
The programmed death-1 receptor, PD-1, is a negative regulator of T-cell activation. The PD-1.3 polymorphism of the PD-1 gene (PDCD1) has been previously shown to be associated with several autoimmune and inflammatory disorders including systemic lupus erythematosus and multiple sclerosis. We examined for the first time PD-1.3 association with another inflammatory disease with strong immune component, IgE-mediated bronchial asthma, its severity and its biochemical markers (total serum IgE and IL-4).



PD-1.3 G/A was genotyped by PCR-RFLP analysis using two different populations: Caucasian (492 Russian individuals) and Asian (276 Buryat individuals).



We found a significant association of the PD-1.3 polymorphism with IgE-mediated bronchial asthma and total serum IgE level in the Russian population. Combined genotype AA+AG was correlated with risk of developing allergic bronchial asthma (OR = 1.78, 95% CI 1.13-2.78, p = 0.011) and lower concentrations of total serum IgE (p = 0.001) compared with the wild-type genotype GG. However, PD-1.3 was not polymorphic in the Buryat population.



PD-1.3 polymorphism of the PD-1 gene (PDCD1) may contribute to the development of allergic asthma in the Russians but not in the Buryats. Our results could be helpful for a better understanding of the effect of this polymorphism on the development of diseases with strong immune components.
a Institute of Biomedical Chemistry (IBMC) , Moscow , Russia.
Elena V
EV
Dmitrieva-Zdorova
a Institute of Biomedical Chemistry (IBMC) , Moscow , Russia.
Marina V
MV
Gabaeva
a Institute of Biomedical Chemistry (IBMC) , Moscow , Russia.
Yuri A
YA
Seregin
a Institute of Biomedical Chemistry (IBMC) , Moscow , Russia.
Nikolay V
NV
Bodoev
a Institute of Biomedical Chemistry (IBMC) , Moscow , Russia.
Olga E
OE
Voronko
D000328:Adult; D044466:Asian People / Q000235:genetics*; D001249:Asthma / Q000208:ethnology* / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics; D007073:Immunoglobulin E / Q000097:blood*; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D061026:Programmed Cell Death 1 Receptor / Q000235:genetics*; D012129:Respiratory Function Tests; D012426:Russia / Q000453:epidemiology; D012720:Severity of Illness Index; D012800:Siberia / Q000453:epidemiology; D044465:White People / Q000235:genetics*
D018836:Inflammation Mediators; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; D007073:Immunoglobulin E
Genetics; genotypes; immunopathogenesis