A new helvolic acid derivative from an endophytic Fusarium sp. of Ficus carica.
A new helvolic acid derivative named helvolic acid methyl ester (1), together with two known helvolic acid compounds, helvolic acid (2) and hydrohelvolic acid (3), were isolated from the fermentation of endophytic fungus Fusarium sp. in Ficus carica leaves. Their structures were elucidated and identified by spectroscopic methods. Compounds 1-3 showed potent antifungal and antibacterial activities.
a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry Ministry of Education , Shaanxi University of Science & Technology , Xi'an , China.
Xi-Ai
XA
Liang
a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry Ministry of Education , Shaanxi University of Science & Technology , Xi'an , China.
Yang-Min
YM
Ma
a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry Ministry of Education , Shaanxi University of Science & Technology , Xi'an , China.|b College of Agronomy and Life Science , Shanxi Datong University , Datong , China.
Hong-Chi
HC
Zhang
b College of Agronomy and Life Science , Shanxi Datong University , Datong , China.
Rui
R
Liu
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D030681:Ficus / Q000382:microbiology*; D005670:Fusarium / Q000378:metabolism*; D005672:Fusidic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; C000617377:helvolic acid methyl ester; D005672:Fusidic Acid; C011267:helvolic acid
Ficus carica; Fusarium sp; Helvolic acid methyl ester; antifungal activity; endophytic fungus