The value of combined elevation of D-dimer and neopterin as a predictive parameter for early stage acute mesenteric ischemia: An experimental study.
Background The diagnosis of acute mesenteric ischemia is variable. Early diagnosis is important for reducing the mortality and morbidity rates. Aim This experimental study aims to investigate the diagnostic utility of D-dimer and neopterin as a marker for the early stage of acute mesenteric ischemia caused by occlusion of superior mesenteric artery. Methods The levels of D-dimer and neopterin were measured using an animal acute mesenteric ischemia model in 21 male rabbits. Superior mesenteric artery occlusion (Group 1, n = 14) and control (Group 2, n = 7) groups were identified. Blood samples at different times are collected from each rabbits. Blood samples from superior mesenteric artery occlusion group were taken 30 min after anesthesia but before laparotomy, 1, 2, and 3 h after superior mesenteric artery ligation. Blood samples from control group were taken 1 h before, 1 and 3 h after anesthesia and laparotomy. The D-dimer and neopterin levels of each blood sample were measured. Results The probability of acute mesenteric ischemia was found to be 36 times higher when the D-dimer level was over 0.125 ng/L, whereas the probability was 19.2 times higher when the neopterin level was over 1.25 nmol/L. Conclusions In this experimental study, the combined elevation of two significant markers, D-dimer and neopterin, may be helpful for the early diagnosis of acute mesenteric ischemia.
1 Department of General Surgery, Gulhane Medical School, Turkey.
Ali Kagan
AK
Coskun
2 Department of Pharmacology, Gulhane Medical School, Turkey.|3 Department of Pharmacology, Ataturk University, Turkey.
Zekai
Z
Halici
4 Department of Pediatric Surgery, Gulhane Medical School, Turkey.|5 Department of Pediatric Surgery, Ataturk University, Turkey.
Akgun
A
Oral
6 Faculty of Pharmacy, Ataturk University, Turkey.
Yasin
Y
Bayir
7 Department of Endocrinology, Gulhane Medical School, Turkey.
Ferhat
F
Deniz
8 Department of Biochemistry, Gulhane Medical School, Turkey.
Tuncer
T
Caycı
1 Department of General Surgery, Gulhane Medical School, Turkey.
Oner
O
Mentes
9 Department of Cardiovascular Surgery, Gulhane Medical School, Turkey.
Bilgehan Savas
BS
Oz
1 Department of General Surgery, Gulhane Medical School, Turkey.
Ali
A
Harlak
1 Department of General Surgery, Gulhane Medical School, Turkey.
Taner
T
Yigit
1 Department of General Surgery, Gulhane Medical School, Turkey.
Orhan
O
Kozak
1 Department of General Surgery, Gulhane Medical School, Turkey.
Yusuf
Y
Peker
D000208:Acute Disease; D000818:Animals; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D042241:Early Diagnosis; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D008026:Ligation; D008297:Male; D017538:Mesenteric Artery, Superior / Q000601:surgery; D065666:Mesenteric Ischemia / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D008641:Mesenteric Vascular Occlusion / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D019798:Neopterin / Q000097:blood*; D011237:Predictive Value of Tests; D012372:ROC Curve; D011817:Rabbits; D013997:Time Factors; D015854:Up-Regulation
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D019798:Neopterin
D-dimer; acute mesenteric ischemia; neopterin; rabbit