Nevoid hyperkeratosis of the nipple and the areola.
A 25-year-old woman presented to our dermatology unit with progressive diffuse thickening of the both areolas. A skin biopsy was taken from the right areola showing irregular filiform acanthosis with elongation and anastomosis of rete ridges, irregular orthokeratotic hyperkeratosis, pseudocyst formation, and hyperpigmentation of the basal layer. The cause of nevoid hyperkeratosis of the nipple and areola is unknown. Eighty percent of cases occur in women and are often manifested during puberty or pregnancy. The disease may also occur in men receiving hormonal therapy. There is no uniformly effective treatment. Dermatologists, gynecologists, and general practitioners have an important part to play in recognizing this condition that may be underdiagnosed because of lack of awareness.
Complejo Hospitalario Torrecardenas, Almeria.
Maria Jose
MJ
Alonso-Corral
Cristina
C
Garrido-Colmenero
Fernando
F
Martinez-Ortiz
Ricado
R
Ruiz-Villaverde
D000328:Adult; D001941:Breast Diseases / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000175:diagnosis / Q000473:pathology*; D007642:Keratosis / Q000175:diagnosis / Q000473:pathology*; D009558:Nipples / Q000473:pathology*