Immediate postoperative evaluation of enteric anastomosis after the use of meloxicam in rats
To compare ileal anastomoses in the immediate postoperative healing period after meloxicam use.



Forty two male Wistar rats were randomly divided into two groups of 21, COX and control group. To COX meloxicam in combination with morphine was given in 3 days period. Control group received only morphine during the same period. Each group was divided into three sub-groups of 7, which were euthanized at 5, 10, and 21 days postoperatively. Comparison was based in histological evaluation of collagen type I and III using sirius red, immunohistochemical through vascular endothelial growth factor and matrix metalloproteinase-9.



Healing process in scheduled periods did not show significant differences (p>0.05) between the COX and control groups during any of the periods.



The use of meloxicam in the postoperative period following ileal anastomosis did not affect healing.
Fellow Master degree, Postgraduate Program in Animal Sciences, Pontificia Universidade Católica do Paraná (PUCPR), Curitiba-PR, Brazil. Acquisition, analysis and interpretation of data; manuscript writing., Pontifícia Universidade Católica do Paraná, Pontificia Universidade Católica do Paraná, Curitiba PR , Brazil.
Eros Luiz de
EL
Sousa
PhD, Full Professor, Postgraduate Program in Animal Sciences, PUCPR, Curitiba-PR, Brazil. Scientific and intellectual content of the study, critical revision., Pontifícia Universidade Católica do Paraná, PUCPR, Curitiba PR , Brazil.
Antônio Felipe Paulino de Figueiredo
AF
Wouk
PhD, Full Professor, Postgraduate Program in Principles of Surgery, Faculdade Evangélica do Paraná (FEPAR), Curitiba-PR, Brazil. Critical revision, final approval the version to be published., Faculdade Evangélica do Paraná, Curitiba PR , Brazil.
Osvaldo
O
Malafaia
PhD, Full Professor, Postgraduate Program in Principles of Surgery, Faculdade Evangélica do Paraná (FEPAR), Curitiba-PR, Brazil. Critical revision, final approval the version to be published., Faculdade Evangélica do Paraná, Curitiba PR , Brazil.
Jurandir Marcondes
JM
Ribas-Filho
PhD, Full Professor. Postgraduate Program in Health Sciences, PUCPR, Curitiba-PR, Brazil. Scientific and intellectual content of the study, critical revision., Pontifícia Universidade Católica do Paraná, PUCPR, Curitiba PR , Brazil.
Lucia
L
Noronha
PhD, Assistant Professor, FEPAR, Curitiba-PR, Brazil. Scientific and intellectual content of the study, critical revision., FEPAR, Curitiba PR , Brazil.
Silvana Maris
SM
Cirio
PhD, Full Professor. Postgraduate Program in Animal Sciences, PUCPR, Curitiba-PR, Brazil. Scientific and intellectual content of the study, statistical analyses, critical revision, final approval the version to be published., Pontifícia Universidade Católica do Paraná, PUCPR, Curitiba PR , Brazil.
Claudia Turra
CT
PimpãoVII
Fellow Postdoc degree, Postgraduate Program in Principles of Surgery, FEPAR, Curitiba-PR, Brazil. Technical procedures., FEPAR, Curitiba PR , Brazil.
Carlos Hespanha
CH
Marinho
PhD, Full Professor, School of Veterinary Medicine, Universidade Federal do Paraná (UFPR), Curitiba-PR, Brazil. Scientific and intellectual content of the study, critical revision., Universidade Federal do Paraná, School of Veterinary Medicine, Universidade Federal do Paraná, Curitiba PR , Brazil.
Maria Fernanda
MF
Torres
Graduate student, School of Medicine, FEPAR, Curitiba-PR, Brazil. Technical procedures., School of Medicine, FEPAR, Curitiba PR , Brazil.
Yorgos Luiz Santos de Salles
YL
Graça
MD, Gastrointestinal Surgeon, Hospital Angelina Caron, Campina Grande do Sul-PR, Brazil. Technical procedures., Hospital Angelina Caron, Campina Grande do Sul PR , Brazil.
Daniel Dantas
DD
Ferrarin
D000714:Anastomosis, Surgical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D024042:Collagen Type I / Q000378:metabolism; D024061:Collagen Type III / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D007082:Ileum / Q000098:blood supply / Q000601:surgery*; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000187:drug effects / Q000378:metabolism; D000077239:Meloxicam; D023421:Models, Animal; D018919:Neovascularization, Physiologic / Q000187:drug effects; D011184:Postoperative Period; D011897:Random Allocation; D017208:Rats, Wistar; D040262:Receptors, Vascular Endothelial Growth Factor / Q000187:drug effects / Q000378:metabolism; D013843:Thiazines / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D024042:Collagen Type I; D024061:Collagen Type III; D016861:Cyclooxygenase Inhibitors; D013843:Thiazines; D013844:Thiazoles; D040262:Receptors, Vascular Endothelial Growth Factor; D020780:Matrix Metalloproteinase 9; D000077239:Meloxicam