DBSI server: DNA binding site identifier.
: Protein-nucleic acid interactions are among the most important intermolecular interactions in the regulation of cellular events. Identifying residues involved in these interactions from protein structure alone is an important challenge. Here we introduce the webserver interface to DNA Binding Site Identifier (DBSI), a powerful structure-based SVM model for the prediction and visualization of DNA binding sites on protein structures. DBSI has been shown to be a top-performing model to predict DNA binding sites on the surface of a protein or peptide and shows promise in predicting RNA binding sites.



Server is available at http://dbsi.mitchell-lab.org



jcmitchell@wisc.edu



Supplementary data are available at Bioinformatics online.
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Shravan
S
Sukumar
School of Life Sciences, Anhui University, Hefei, Anhui Province 230601, China.
Xiaolei
X
Zhu
Small Molecule Screening Facility.
Spencer S
SS
Ericksen
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA Department of Mathematics, University of Wisconsin-Madison, Madison, WI 53706, USA.
Julie C
JC
Mitchell
D001665:Binding Sites; D004247:DNA; D004268:DNA-Binding Proteins; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins; D060388:Support Vector Machine
D004268:DNA-Binding Proteins; D011506:Proteins; D004247:DNA