Synthesis and Biological Activities of Substituted 4,4,4-Trifluoro-3-(indoIe-3-)butyric Acids, Novel Fluorinated Plant Growth Regulators.
Substituted 4,4,4-trifluoro-3-(indole-3-)butyric acids (TFIBAs), novel fluorinated plant growth regulators, were easily synthesized from substituted 2,2,2-trifluoro-l-(indole-3-)ethanols. The synthetic substituted TFIBAs showed marked root growth-promoting activity toward Chinese cabbage, lettuce, and rice plants. 5-MeO-2-Me-TFIBA (2d) had especially strong promoting activity toward Chinese cabbage, while 5-Me- TFIBA (2b) markedly promoted the root growth of all three plants. The promoting activity of TFIBAs halogenated at the 5-position in the indole nucleus of the molecule (5-Br- and 5-C1-TFIBA (2e and 2g)) was also greater than the activity of TFIBA, the original non-substituted compound. 5-N02-TFIBA (2h) with a strong electron-withdrawing group showed only very weak root growth-promoting activity.
a Laboratory of Bioorganic Chemistry, Department of Chemistry , National Industrial Research Institute of Nagoya , 1-1 Hirate-cho, Kita-ku, Nagoya 462 , Japan.
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Katayama
a Laboratory of Bioorganic Chemistry, Department of Chemistry , National Industrial Research Institute of Nagoya , 1-1 Hirate-cho, Kita-ku, Nagoya 462 , Japan.
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RK
Gautam
4,4,4-trifluoro-3-(indole-3-)butyric acids; fluorinated plant growth regulators; root growth-promoting activity