Protein undernutrition during development and oxidative impairment in the central nervous system (CNS): potential factors in the occurrence of metabolic syndrome and CNS disease.
Mitochondria play a regulatory role in several essential cell processes including cell metabolism, calcium balance and cell viability. In recent years, it has been postulated that mitochondria participate in the pathogenesis of a number of chronic diseases, including central nervous system disorders. Thus, the concept of mitochondrial function now extends far beyond the common view of this organelle as the 'powerhouse' of the cell to a new appreciation of the mitochondrion as a transducer of early metabolic insult into chronic disease in later life. In this review, we have attempted to describe some of the associations between nutritional status and mitochondrial function (and dysfunction) during embryonic development with the occurrence of neural oxidative imbalance and neurogenic disease in adulthood.
1Neuropsychiatry and Behavior Science Graduate Program,Federal University of Pernambuco,Vitória de Santo Antão,Brazil.
D J S
DJ
Ferreira
2Department of Medicine,Uniformed Service University of Health Science (USUHS),Bethesda,MD,USA.
D F
DF
Sellitti
1Neuropsychiatry and Behavior Science Graduate Program,Federal University of Pernambuco,Vitória de Santo Antão,Brazil.
C J
CJ
Lagranha
developmental stage; mental health/illness; metabolic syndrome; molecular/cellular; outcome/system