Diagnostic value of KLK6 as an ovarian cancer biomarker: A meta-analysis.
Kallikrein-related peptidase 6 (KLK6) is a new potential serum biomarker of ovarian cancer. The aim of the present study was to assess the diagnostic value of KLK6 systematically for ovarian cancer. All the selected studies regarding the changes of KLK6 in ovarian cancer were published prior to April 2015. Five studies involving 485 patients with ovarian cancer, 420 benign cysts and 245 healthy controls met the inclusion criteria. The value of sensitivity, specificity, positive-likelihood ratio (LR+), negative-likelihood ratio (LR-) and area under the receiver operating characteristic curve (ROC) were obtained. All these indices were used to evaluate the diagnostic value of KLK6 for ovarian cancer. The values of sensitivity, specificity, LR+ and LR- (95% confidence interval) of KLK6 were 0.50 (0.47-0.54), 0.91 (0.89-0.93), 7.20 (3.34-15.52) and 0.51 (0.43-0.62), respectively. The area under the summary ROC of KLK6 was 0.86. The index of Q* was 0.79. In conclusion, KLK6 showed high specificity for the diagnosis of ovarian cancer. It can improve the diagnostic accuracy of cancer antigen 125 (CA125). A combined panel of CA125 and KL K6 shows a high diagnostic efficiency for advanced ovarian cancer. Owing to the small number of studies and lack of samples, additional studies meeting the inclusion criteria are required to further analyze the diagnostic value of KLK6 for ovarian cancer.
Graduate School of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China.
Fan
F
Yang
Department of Laboratory Medicine, General Hospital of Ji'nan Military Command Region, Ji'nan, Shandong 250031, P.R. China.
Zhi-DE
ZD
Hu
Department of Laboratory Medicine, General Hospital of Ji'nan Military Command Region, Ji'nan, Shandong 250031, P.R. China.
Yingjian
Y
Chen
Department of Laboratory Medicine, General Hospital of Ji'nan Military Command Region, Ji'nan, Shandong 250031, P.R. China.
Cheng-Jin
CJ
Hu
diagnoses; kallikrein-related peptidase 6; meta-analysis; ovarian cancer