Reversal of neuromuscular blockade with sugammadex or neostigmine/atropine: Effect on postoperative gastrointestinal motility.
OBJECTIVE
To compare sugammadex with conventional reversal of neuromuscular block in terms of postoperative gastrointestinal motility.


METHODS
Double blinded, randomized, controlled clinical trial.


METHODS
Operating room, postoperative recovery area.


METHODS
Seventy-two patients with ASA physical status I or II, scheduled for total thyroid surgery were studied.


METHODS
When 4 twitches were observed on train-of-four stimulation, neuromuscular block was reversed conversatively in the control group, and with sugammadex in the study group.


METHODS
Time to first flatus and feces, incidence of postoperative nausea, vomiting, diarrhea and constipation were collected.


RESULTS
Median time of first flatus was 24 hours (18-32 [10-36]) in the neostigmine group, and 24 (18-28 [12-48]) in the sugammadex group (P > .05). Median (IQR) time of first feces was 24 hours (18-36 [10-48]) in neostigmine group, 32 hours (28-36 [12-72]) in sugammadex group (P > .05). There were no occurrences of nausea, vomiting, diarrhea, or constipation.


CONCLUSIONS
Sugammadex may be safely used in cases where postoperative ileus is expected.
Recep Tayyip Erdogan University, Medical Faculty, Department of Anaesthesiology and Reanimation, Rize, Turkey.
A
A
Sen
Recep Tayyip Erdogan University, Medical Faculty, Department of Anaesthesiology and Reanimation, Rize, Turkey. Electronic address: berdivanli@gmail.com.
B
B
Erdivanli
Sakarya University, Medical Faculty, Anaesthesiology and Reanimation, Sakarya, Turkey.
Y
Y
Tomak
Recep Tayyip Erdogan University, Medical Faculty, Department of General Surgery, Rize, Turkey.
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A
Pergel
D000762:Anesthesia Recovery Period; D001285:Atropine / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004311:Double-Blind Method; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009388:Neostigmine / Q000494:pharmacology*; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology; D011184:Postoperative Period; D000077122:Sugammadex; D013997:Time Factors; D047408:gamma-Cyclodextrins / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D018727:Muscarinic Antagonists; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D009388:Neostigmine; D001285:Atropine
Constipation; Neostigmine; Neuromuscular agents; Postoperative period; Sugammadex