A Novel Intra-aortic Device Designed for Coronary Blood Flow Amplification in Unrevascularizable Patients.
Patients with unrevascularizable coronary artery disease represent a substantial number of all patients with coronary disease. However, their therapeutic options are limited; they endure recurrent hospitalizations, a poor quality of life and prognosis. We aim to investigate a novel alternative approach to the treatment of this common medical condition by using a specialized intra-aortic device with coiling properties capable of enhancing diastolic coronary flow. Both a mathematical analysis and in vitro study presented in the current study have yielded enhanced coronary diastolic blood flow and energetic advantages. We suggest that this original approach might be implicated in severely symptomatic unrevascularizable patients.
Department of Internal Medicine A, Rambam Health Care Campus, Ruth and Bruce Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel. enussi@yahoo.com.
Udi
U
Nussinovitch
CorAssist Cardiovascular Ltd, Haifa, Israel.
Giorgi
G
Shtenberg
Department of Cardiology, Rambam Health Care Campus, Ruth and Bruce Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel.
Ariel
A
Roguin
CorAssist Cardiovascular Ltd, Haifa, Israel.|Department of Cardiology, Rambam Health Care Campus, Ruth and Bruce Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel.
Yair
Y
Feld
D001011:Aorta / Q000503:physiopathology*; D062186:Arterial Pressure; D001783:Blood Flow Velocity; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D003326:Coronary Circulation; D057510:Endovascular Procedures / Q000295:instrumentation*; D004735:Energy Transfer; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D020959:Polyethylene; D011474:Prosthesis Design; D012039:Regional Blood Flow; D012720:Severity of Illness Index; D013193:Stainless Steel; D015607:Stents; D013997:Time Factors; D014655:Vascular Resistance
D013193:Stainless Steel; D020959:Polyethylene
Angina pectoris; Coronary artery disease; Diastolic flow; Intra-aortic device; Ischemic heart disease; Unrevascularizable