The association between human papillomavirus infection and female lung cancer: A population-based cohort study.
Lung cancer is the leading cause of cancer deaths among Taiwanese women. Human papillomavirus (HPV) has been detected in lung cancer tissues. The aim of this study was to investigate the association between HPV infection and lung cancer among the Taiwanese women. The analytical data were collected from the longitudinal health insurance databases (LHID 2005 and 2010) of the National Health Insurance Research Database (NHIRD). The study participants were 30 years and older and included 24,162 individuals who were identified with HPV infection from 2001 to 2004 and 1,026,986 uninfected individuals. Lung cancer incidence among infected and uninfected individuals was compared using the univariate and multivariate regression models. Among the total participants, 24,162 individuals were diagnosed with HPV. After adjusting for age, gender, low income, residential area, and comorbidity, the risk of lung cancer was higher in women (hazard ratio [HR] 1.263, 95% CI 1.015-1.571), while all cancer risks were high in both men and women with corresponding hazard ratios (HR) of 1.161 (95% CI 1.083-1.245) and HR 1.240 (95% CI 1.154-1.331), respectively. This study showed a significant increase in lung cancer risk among Taiwanese women who were exposed to HPV infection.
School of Medicine, Chung Shan Medical University Department of Thoracic Surgery, Chung Shan Medical University Hospital Department of Public Health and Institute of Public Health, Chung Shan Medical University Department of Medical Research, Tungs' Taichung Metro Harbor Hospital Department of Food and Nutrition, Providence University Divisions of Medical Oncology and Pulmonary Medicine, Chung Shan Medical University Hospital, Taichung Department of Psychiatry, Chung Shan Medical University Hospital Chung Yuan Christian University, Taoyuan City Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Frank Cheau-Feng
FC
Lin
Jing-Yang
JY
Huang
Stella Ching-Shao
SC
Tsai
Oswald Ndi
ON
Nfor
Ming-Chih
MC
Chou
Ming-Fang
MF
Wu
Chun-Te
CT
Lee
Cheng-Feng
CF
Jan
Yung-Po
YP
Liaw
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000821:virology; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D011159:Population Surveillance / Q000379:methods*; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D013624:Taiwan / Q000453:epidemiology