Thyroid dysfunction in the era of precision medicine.
The launching of the Precision Medicine Initiative by the President of the United States in January 2015 was an invitation for all healthcare professionals to review their practice. This call should stimulate thyroidologists working in different areas (from basic research or epidemiology to the frontline of the clinical arena or to those designing public health programs) to be aware of this new outlook. The aim of the initiative is to eradicate imprecision in estimating the probability of a correct diagnosis, to be as sure as possible of the most effective treatment, and to maximize the chances of a successful outcome. This paper summarizes some of the current challenges faced by endocrinologists in the field of thyroid dysfunction, and illustrates how precision medicine may improve diagnosis and therapy in the future.
Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain; IdiSNA (Instituto de investigación en la salud de Navarra), Spain. Electronic address: jcgalofre@unav.es.
Juan C
JC
Galofré
Department of Endocrinology and Nutrition, Hospital Ramón y Cajal, Department of Medicine, University of Alcalá de Henares, Madrid, Spain.
Juan J
JJ
Díez
Division of Endocrinology, Diabetes, and Metabolism, The John Hopkins University School of Medicine, Baltimore, MD, USA.
David S
DS
Cooper
D001323:Autoantibodies / Q000097:blood; D004704:Endocrinology / Q000639:trends*; D005260:Female; D005544:Forecasting; D020022:Genetic Predisposition to Disease; D006801:Humans; D007167:Immunotherapy; D057285:Precision Medicine; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000628:therapy; D011364:Professional Practice; D012106:Research / Q000639:trends; D013959:Thyroid Diseases / Q000097:blood / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D014481:United States
D001323:Autoantibodies; D013963:Thyroid Hormones; D013972:Thyrotropin
Disfunción tiroidea; Enfermedades tiroideas; Hipertiroidismo; Hipotiroidismo; Hyperthyroidism; Hypothyroidism; Medicina de precisión; Precision medicine; Thyroid disease; Thyroid dysfunction