Mathematical Model of Self-Oscillations of Activity of Kai Proteins.
A non-autocatalytic mathematical model of self-oscillations in vitro in solutions of cyanobacterial Kai proteins (KaiA, KaiB, KaiC) and ATP is suggested. This model describes the process of phosphorylation/dephosphorylation of KaiC protein, which is accelerated by KaiA and inhibited by KaiB. The method of metabolic control analysis is used to show that frequency (period) as well as amplitude of self-oscillations of components of Kai proteins are temperature-compensated.
Azerbaijan Medical University, Baku, AZ1022, Azerbaijan. shahinru@yahoo.com.
Sh K
ShK
Bayramov
D000255:Adenosine Triphosphate / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D000458:Cyanobacteria / Q000378:metabolism; D007700:Kinetics; D008958:Models, Molecular; D010766:Phosphorylation; D011485:Protein Binding; D013696:Temperature
D001426:Bacterial Proteins; D000255:Adenosine Triphosphate