SinEx DB: a database for single exon coding sequences in mammalian genomes.
Eukaryotic genes are typically interrupted by intragenic, noncoding sequences termed introns. However, some genes lack introns in their coding sequence (CDS) and are generally known as 'single exon genes' (SEGs). In this work, a SEG is defined as a nuclear, protein-coding gene that lacks introns in its CDS. Whereas, many public databases of Eukaryotic multi-exon genes are available, there are only two specialized databases for SEGs. The present work addresses the need for a more extensive and diverse database by creating SinEx DB, a publicly available, searchable database of predicted SEGs from 10 completely sequenced mammalian genomes including human. SinEx DB houses the DNA and protein sequence information of these SEGs and includes their functional predictions (KOG) and the relative distribution of these functions within species. The information is stored in a relational database built with My SQL Server 5.1.33 and the complete dataset of SEG sequences and their functional predictions are available for downloading. SinEx DB can be interrogated by: (i) a browsable phylogenetic schema, (ii) carrying out BLAST searches to the in-house SinEx DB of SEGs and (iii) via an advanced search mode in which the database can be searched by key words and any combination of searches by species and predicted functions. SinEx DB provides a rich source of information for advancing our understanding of the evolution and function of SEGs.Database URL: www.sinex.cl.
Center for Bioinformatics and Genome Biology, Fundacion Ciencia & Vida and Facultad de Ciencias Biologicas, Universidad Andres Bello, Avda Zañartu 1482, Santiago, Chile.
Roddy
R
Jorquera
Center for Bioinformatics and Genome Biology, Fundacion Ciencia & Vida and Facultad de Ciencias Biologicas, Universidad Andres Bello, Avda Zañartu 1482, Santiago, Chile.
Rodrigo
R
Ortiz
Center for Bioinformatics and Genome Biology, Fundacion Ciencia & Vida and Facultad de Ciencias Biologicas, Universidad Andres Bello, Avda Zañartu 1482, Santiago, Chile.
F
F
Ossandon
Center for Bioinformatics and Genome Biology, Fundacion Ciencia & Vida and Facultad de Ciencias Biologicas, Universidad Andres Bello, Avda Zañartu 1482, Santiago, Chile.
Juan Pablo
JP
Cárdenas
Center for Bioinformatics and Genome Biology, Fundacion Ciencia & Vida and Facultad de Ciencias Biologicas, Universidad Andres Bello, Avda Zañartu 1482, Santiago, Chile.
Rene
R
Sepúlveda
Center for Bioinformatics and Genome Biology, Fundacion Ciencia & Vida and Facultad de Ciencias Biologicas, Universidad Andres Bello, Avda Zañartu 1482, Santiago, Chile.
Carolina
C
González
Center for Bioinformatics and Genome Biology, Fundacion Ciencia & Vida and Facultad de Ciencias Biologicas, Universidad Andres Bello, Avda Zañartu 1482, Santiago, Chile dsholmes2000@yahoo.com.
David S
DS
Holmes
D000818:Animals; D030541:Databases, Genetic; D005091:Exons; D015894:Genome, Human; D006801:Humans