MicroRNA-1 properties in cancer regulatory networks and tumor biology.
Short non-coding microRNAs have been identified to orchestrate crucial mechanisms in cancer progression and treatment resistance. MicroRNAs are involved in posttranscriptional modulation of gene expression and therefore represent promising targets for anticancer therapy. As mircoRNA-1 (miR-1) exerted to be predominantly downregulated in the majority of examined tumors, miR-1 is classified to be a tumor suppressor with high potential to diminish tumor development and therapy resistance. Here we review the complex functionality of miR-1 in tumor biology.
Department of Urology, University Medicine Greifswald, Greifswald, Germany.
Martin
M
Weiss
Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany.
Lars-Ove
LO
Brandenburg
Department of Urology, University Medicine Greifswald, Greifswald, Germany.
Martin
M
Burchardt
Department of Urology, University Medicine Greifswald, Greifswald, Germany. Electronic address: matthias.stope@uni-greifswald.de.
Matthias B
MB
Stope
D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics; D016923:Cell Death; D002465:Cell Movement; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D011379:Prognosis
D014408:Biomarkers, Tumor; C544547:MIRN1 microRNA, human; D035683:MicroRNAs
Biomarker; Cancer; Cellular response; Resistance; microRNA-1