The FaceBase Consortium: a comprehensive resource for craniofacial researchers.
The FaceBase Consortium, funded by the National Institute of Dental and Craniofacial Research, National Institutes of Health, is designed to accelerate understanding of craniofacial developmental biology by generating comprehensive data resources to empower the research community, exploring high-throughput technology, fostering new scientific collaborations among researchers and human/computer interactions, facilitating hypothesis-driven research and translating science into improved health care to benefit patients. The resources generated by the FaceBase projects include a number of dynamic imaging modalities, genome-wide association studies, software tools for analyzing human facial abnormalities, detailed phenotyping, anatomical and molecular atlases, global and specific gene expression patterns, and transcriptional profiling over the course of embryonic and postnatal development in animal models and humans. The integrated data visualization tools, faceted search infrastructure, and curation provided by the FaceBase Hub offer flexible and intuitive ways to interact with these multidisciplinary data. In parallel, the datasets also offer unique opportunities for new collaborations and training for researchers coming into the field of craniofacial studies. Here, we highlight the focus of each spoke project and the integration of datasets contributed by the spokes to facilitate craniofacial research.
Structural Informatics Group, Department of Biological Structure, University of Washington, Seattle, WA 98195, USA.
James F
JF
Brinkley
Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, USA.
Shannon
S
Fisher
Department of Orthopedic Research, Boston Children's Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Matthew P
MP
Harris
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Greg
G
Holmes
Cell and Developmental Biology, School of Medicine, University of Colorado, Aurora, CO 80045, USA.
Joan E
JE
Hooper
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Ethylin Wang
EW
Jabs
Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado, Aurora, CO 80045, USA.
Kenneth L
KL
Jones
Information Sciences Institute, Viterbi School of Engineering, University of Southern California, Marina del Rey, CA 90292, USA.
Carl
C
Kesselman
Program in Craniofacial Biology, Departments of Orofacial Sciences and Pediatrics, Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA.
Ophir D
OD
Klein
Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Richard L
RL
Maas
Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Mary L
ML
Marazita
Program in Craniofacial Biology, Departments of Orofacial Sciences and Pediatrics, Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA.
Licia
L
Selleri
Human Medical Genetics and Genomics Program, School of Medicine, University of Colorado, Aurora, CO 80045, USA.
Richard A
RA
Spritz
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Harm
H
van Bakel
Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA School of Natural Sciences, University of California Merced, Merced, CA 95343, USA.
Axel
A
Visel
Department of Craniofacial Biology, School of Dental Medicine, University of Colorado, Aurora, CO 80045, USA.
Trevor J
TJ
Williams
Department of Chemical and Systems Biology and of Developmental Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Joanna
J
Wysocka
Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA ychai@usc.edu.
Yang
0000-0002-8943-0861
Y
Chai
D000818:Animals; D047369:Chromatin Immunoprecipitation; D019295:Computational Biology; D016208:Databases, Factual; D005145:Face / Q000196:embryology*; D023281:Genomics; D006801:Humans; D051379:Mice; D023421:Models, Animal; D012108:Research Personnel; D012886:Skull / Q000196:embryology*; D015027:Zebrafish
Craniofacial development; Data resource; FaceBase Consortium