Prophylactic acetylsalicylic acid attenuates the inflammatory response but fails to protect exercise-induced liver damage in exercised rats.
This study evaluated the effects of acetylsalicylic acid (ASA) on exercise-induced inflammatory response, muscle damage, and liver injury in rats. Wistar-Kyoto (WKY) rats were divided into six groups: control (C), exercise (E), C+20mg ASA, E+20mg ASA, C+100mg/kg ASA, and E+100mg ASA groups. ASA or a vehicle was orally administered through gavage 1h before a treadmill test. Upon trial completion, blood was drawn at 1, 12, and 24h for biochemical analysis, and livers were excised at 24h for a histological assessment. Our results revealed that 100mg/kg ASA significantly reduced interleukin (IL)-6 and tumor necrosis factor (TNF)-α levels in the E groups; however, the IL-10 level was considerably increased. Moreover, aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels and histological hepatic damage increased significantly in the E+100mg ASA group compared with the corresponding changes in the E group. These results suggest that the prophylactic administration of particularly high-dose ASA alleviates exercise-induced inflammatory response but exacerbates liver injury.
Holistic Education Center, Mackay Medical College, New Taipei City, Taiwan, ROC. Electronic address: kchsports@mmc.edu.tw.
Kuo-Chin
KC
Huang
Department of Nursing, St. Mary's Medicine, Nursing and Management College, Yi-Lan, Taiwan, ROC. Electronic address: chiuyiham@hotmail.com.
Yi-Han
YH
Chiu
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, ROC. Electronic address: liaonms@mail.nctu.edu.tw.
Kuang-Wen
KW
Liao
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, ROC. Electronic address: brant77123@hotmail.com.
Chun-Yen
CY
Ke
Department of Nursing, Tzu Chi University of Science and Technology, Hualien, Taiwan, ROC. Electronic address: guggilee@msn.com.
Chung-Jen
CJ
Lee
Department of Nursing, Mackay Medical College, New Taipei City, Taiwan, ROC. Electronic address: yfchaomk@mmc.edu.tw.
Yann-Fen C
YC
Chao
Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan, ROC. Electronic address: fish@gms.tcu.edu.tw.
Ru-Ping
RP
Lee
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology; D016753:Interleukin-10 / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000009:adverse effects*; D051381:Rats; D011921:Rats, Inbred WKY; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001241:Aspirin
Aspirin; Exhaustion exercise; Liver injury; Nonsteroidal antiinflammatory drug