Influence of the Surface Acidity of the Alumina on the Sustained Release of Ketoprofen.
This work reports the immobilization of ketoprofen into mesoporous alumina, prepared in different way, to assess their possible applications as a matrix for controlled drug release. The acids' surface properties of the aluminas and their effect on the drug content and release rate were also analyzed. The systems have been characterized by powder X-ray diffractometry, Fourier transformer infrared spectroscopy (FT-IR), N2 adsorption desorption, transmission electron microscopy, and FT-IR of pyridine adsorption. The results show that the drug is incorporated inside the pores of mesoporous alumina, and the content and release rate depend of surface acidity, when increase the surface acidity decrease the drug content and increase the release rate.
GIR-QUESCAT, Departamento de Química Inorgánica, Facultad de Farmacia, University of Salamanca, Salamanca 37007, Spain.
Soledad
S
San Roman
GIR-QUESCAT, Departamento de Química Inorgánica, Facultad de Farmacia, University of Salamanca, Salamanca 37007, Spain.
Jesús
J
Gullón
GIR-QUESCAT, Departamento de Química Inorgánica, Facultad de Farmacia, University of Salamanca, Salamanca 37007, Spain. Electronic address: arco@usal.es.
Margarita
M
Del Arco
GIR-QUESCAT, Departamento de Química Inorgánica, Facultad de Farmacia, University of Salamanca, Salamanca 37007, Spain. Electronic address: cris@usal.es.
Cristina
C
Martín
D000143:Acids; D000327:Adsorption; D000537:Aluminum Oxide / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D016503:Drug Delivery Systems; D007660:Ketoprofen / Q000008:administration & dosage* / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D016062:Porosity; D011725:Pyridines / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014961:X-Ray Diffraction
D000143:Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D011725:Pyridines; D007660:Ketoprofen; D000537:Aluminum Oxide
FT-IR; acid/base; adsorption; drugs delivery systems; inclusion compounds