Cost-utility analysis of magnetoencephalography used to inform intracranial electrode placement in patients with drug resistant epilepsy: a model based analysis.
OBJECTIVE
We estimated the cost-effectiveness of adding magnetoencephalography to a standard assessment for epilepsy surgery consisting of neuropsychology, magnetic resonance imagining, scalp electroencephalography, video electroencephalography and intracranial electroencephalography, in the capacity of informing intracranial electroencephalography electrode placement.


METHODS
We used Microsoft Excel (2007) to construct a decision model. Discounted costs and quality adjusted life years are aggregated to calculate incremental cost-effectiveness ratios. Sensitivity analyses are conducted to assess robustness of findings.


RESULTS
Our base case analysis yielded a result of $14 300 per quality adjusted life year gained. A total of 82.7% of probabilistic sensitivity analysis iterations resulted in incremental cost-effectiveness ratios below $100 000 in 2014 Canadian dollars.


CONCLUSIONS
Our findings demonstrate that the inclusion of Magnetoencephalography in the assessment for epilepsy surgery in the capacity of informing intracranial electroencephalography electrode placement is likely not cost saving but does represent a reasonable allocation of resources from a value for money perspective.
Centre for Clinical Research, Nova Scotia Health Authority, Halifax, NS, Canada.
Patrick
P
Berrigan
Biomedical Translational Imaging Centre (BIOTIC), IWK Health Centre, Halifax, NS, Canada.
Tim
T
Bardouille
Biomedical Translational Imaging Centre (BIOTIC), IWK Health Centre, Halifax, NS, Canada.
Matt
M
MacLellan
Department of Paediatrics, IWK Health Centre, Dalhousie University, Halifax, NS, Canada.
Ismail S
IS
Mohamed
Biomedical Translational Imaging Centre (BIOTIC), IWK Health Centre, Halifax, NS, Canada.
Manjari
M
Murthy
D000328:Adult; D003362:Cost-Benefit Analysis; D003661:Decision Support Techniques; D000069279:Drug Resistant Epilepsy; D004566:Electrodes; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000191:economics*; D008297:Male; D011788:Quality of Life
MEG; cost-effectiveness analysis; epilepsy; magnetoencephalography; utility