Flavivirus modulation of cellular metabolism.
Over the last decade, we have begun to appreciate how flaviviruses manipulate cellular metabolism to establish an optimal environment for their replication. These metabolic changes include the stimulation of glycolysis, in addition to lipid anabolic and catabolic pathways. These processes are thought to promote an energetically favorable state, in addition to modifying membrane lipid composition for viral replication and virion envelopment. Importantly, many of these processes can be pharmacologically inhibited as successful antiviral strategies, at least in cell culture. In this review, we discuss the mechanisms by which flaviviruses alter cellular metabolism, remaining questions, and opportunities for therapeutic development.
Department of Microbiology, The University of Chicago, Chicago, IL 60637, United States.
Tristan X
TX
Jordan
Department of Microbiology, The University of Chicago, Chicago, IL 60637, United States. Electronic address: grandall@bsd.uchicago.edu.
Glenn
G
Randall
D000998:Antiviral Agents / Q000627:therapeutic use; D003716:Dengue Virus / Q000502:physiology; D005416:Flavivirus / Q000502:physiology*; D018177:Flavivirus Infections / Q000378:metabolism* / Q000628:therapy; D006019:Glycolysis; D054884:Host-Pathogen Interactions; D006801:Humans; D050356:Lipid Metabolism; D014779:Virus Replication
D000998:Antiviral Agents