In Situ Generated HypoIodite Activator for the C2 Sulfonylation of Heteroaromatic N-oxides.
A mild approach for direct C2 sulfonylation of heteroaromatic N-oxides with sulfonyl hydrazides affording 2-sulfonyl quinolines/pyridines has been developed. A variety of heteroaromatic N-oxides and sulfonyl hydrazides participate effectively in this transformation which uses hypoiodites (generated in situ from NaI and TBHP) as a means of substrate activators. In this reaction, the N-oxide plays a dual role, acting as a traceless directing group as well as a source of oxygen atom.
Medical College, Hunan Normal University , Changsha 410081, China.
Yuan
Y
Su
Medical College, Hunan Normal University , Changsha 410081, China.
Xuejun
X
Zhou
Medical College, Hunan Normal University , Changsha 410081, China.
Chunlian
C
He
Medical College, Hunan Normal University , Changsha 410081, China.
Wei
W
Zhang
Medical College, Hunan Normal University , Changsha 410081, China.
Xiao
X
Ling
Medical College, Hunan Normal University , Changsha 410081, China.
Xia
X
Xiao