Potassium Channel Remodeling in Heart Disease.
Heart disease produces substantial remodeling of K(+) channels that in general promotes arrhythmia occurrence. In the case of ventricular arrhythmias, K(+) channel remodeling contributes to the arrhythmic risk and increases vulnerability to torsades de pointes with K(+) channel inhibiting drugs. Atrial K(+) channel remodeling caused by atrial fibrillation promotes arrhythmia stability and presents opportunities for the development of new drugs targeting atrial inward rectifier K(+) currents. A better understanding of K(+) channel remodeling will help clinicians to appreciate arrhythmia mechanisms and determinants in a variety of clinical situations and to better manage arrhythmia therapy in patients with heart disease.
Department of Medicine, Research Center, Montreal Heart Institute, University of Montreal, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada; Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec H3G 1Y6, Canada; Faculty of Medicine, University Duisburg-Essen, Hufelandstr. 55, Essen 45122, Germany.
Vincent
V
Algalarrondo
Department of Medicine, Research Center, Montreal Heart Institute, University of Montreal, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada; Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir-William-Osler, Montréal, Québec H3G 1Y6, Canada; Faculty of Medicine, University Duisburg-Essen, Hufelandstr. 55, Essen 45122, Germany. Electronic address: stanley.nattel@icm-mhi.org.
Stanley
S
Nattel
D000200:Action Potentials; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D002320:Cardiovascular Physiological Phenomena; D006801:Humans; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology
D026902:Potassium Channel Blockers; D015221:Potassium Channels
Arrhythmia; Atrial Fibrillation; Cardiac repolarization; Heart disease; Potassium; Potassium channel