Surface-Enhanced Raman Spectroscopy Biosensing: In Vivo Diagnostics and Multimodal Imaging.
This perspective presents recent developments in the application of surface-enhanced Raman spectroscopy (SERS) to biosensing, with a focus on in vivo diagnostics. We describe the concepts and methodologies developed to date and the target analytes that can be detected. We also discuss how SERS has evolved from a "point-and-shoot" stand-alone technique in an analytical chemistry laboratory to an integrated quantitative analytical tool for multimodal imaging diagnostics. Finally, we offer a guide to the future of SERS in the context of clinical diagnostics.
Northwestern University , Department of Chemistry, 2145 Sheridan Road, Evanston, Illinois 60208, United States.
Anne-Isabelle
AI
Henry
Northwestern University , Department of Chemistry, 2145 Sheridan Road, Evanston, Illinois 60208, United States.
Bhavya
B
Sharma
Northwestern University , Department of Chemistry, 2145 Sheridan Road, Evanston, Illinois 60208, United States.
M Fernanda
MF
Cardinal
Northwestern University , Department of Chemistry, 2145 Sheridan Road, Evanston, Illinois 60208, United States.
Dmitry
D
Kurouski
Northwestern University , Department of Chemistry, 2145 Sheridan Road, Evanston, Illinois 60208, United States.
Richard P
RP
Van Duyne
D000818:Animals; D000906:Antibodies / Q000737:chemistry / Q000378:metabolism; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D015415:Biomarkers / Q000032:analysis; D015374:Biosensing Techniques; D004317:Doxorubicin / Q000737:chemistry / Q000627:therapeutic use; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D018613:Microscopy, Confocal; D064847:Multimodal Imaging; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D013059:Spectrum Analysis, Raman
D000906:Antibodies; D000970:Antineoplastic Agents; D015415:Biomarkers; D005456:Fluorescent Dyes; D004317:Doxorubicin