Mutations in Melanocortin-3 Receptor Gene and Human Obesity.
The prevalence of obesity calls for novel therapeutic targets. The melanocortin-3 receptor (MC3R) has been increasingly recognized as an important regulator of energy homeostasis and MC3R has been intensively analyzed in molecular genetic studies for obesity-related traits. Twenty-seven MC3R mutations and two common polymorphic variants have been identified so far in different cohorts. The mutant MC3Rs demonstrate multiple defects in functional analysis and can be cataloged into different classes according to receptor life cycle based classification system. Although the pathogenic role of MC3R in human obesity remains controversial, recent findings in the noncanonical signaling pathway of MC3R mutants have provided new insights. Potential therapeutic strategies for obesity related to MC3R mutations are highlighted.
Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States of America.
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Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States of America. Electronic address: taoyaxi@auburn.edu.
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Tao
D006801:Humans; D009154:Mutation / Q000235:genetics*; D009765:Obesity / Q000235:genetics* / Q000473:pathology*; D010641:Phenotype; D044104:Receptor, Melanocortin, Type 3 / Q000235:genetics*
C505392:MC3R protein, human; D044104:Receptor, Melanocortin, Type 3
adiposity; melanocortin-3 receptor; obesity; pharmacology; signaling