A novel RHCE*02 allele, containing the single-nucleotide change c.460A>G, encodes weakened expression of C and e antigens.
We report a novel RHCE*02 allele in a Swedish blood donor that is characterized by the change c.460A>G (Arg154Gly). The blood donor's red blood cells showed variable reactivity with different monoclonal anti-C and anti-e and antigen strength was markedly weakened. We believe that these changes represent both a quantitative and qualitative alteration of the antigens encoded by this allele.
Clinical Immunology and Transfusion Medicine, Region Skåne, Lund, Sweden.
Åsa
Å
Hellberg
Clinical Immunology and Transfusion Medicine, Region Skåne, Lund, Sweden.
Emma
E
Pesjak
Clinical Immunology and Transfusion Medicine, Region Skåne, Lund, Sweden.
Jessica
J
Karlsson
Clinical Immunology and Transfusion Medicine, Region Skåne, Lund, Sweden. jill.storry@med.lu.se.
Jill R
0000-0003-2940-2604
JR
Storry
D000483:Alleles; D000911:Antibodies, Monoclonal / Q000276:immunology; D001782:Blood Donors; D004912:Erythrocytes / Q000276:immunology / Q000378:metabolism; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006512:Hepatitis B Core Antigens / Q000276:immunology; D006513:Hepatitis B e Antigens / Q000276:immunology*; D006801:Humans; D010641:Phenotype; D012204:Rh-Hr Blood-Group System / Q000235:genetics*
D000911:Antibodies, Monoclonal; D006512:Hepatitis B Core Antigens; D006513:Hepatitis B e Antigens; C066468:RHCE protein, human; D012204:Rh-Hr Blood-Group System