Evaluation of Adipokines, Inflammatory Markers, and Sex Hormones in Simple and Complex Breast Cysts' Fluid.
Objective. The aim of the study was to analyze the association between levels of adipokines in the breast cyst fluid and in the circulation in relation to the type of cysts. Material and Measurements. A cross-sectional study involved 86 women with breast cysts (42 with simple cysts and 44 with complex cysts). Plasma and breast cyst fluid leptin, adiponectin, visfatin/NAMPT, resistin, TNF-α, and IL-6 levels, in addition to serum levels of estradiol, progesterone and prolactin, and anthropometric parameters and body composition (by bioimpedance method), were measured. Results. The levels of leptin, adiponectin, and resistin were significantly lower in breast cyst fluid than in plasma regardless of the cyst type. Contrarily, the levels of visfatin/NAMPT and TNF-α were significantly increased, and IL-6 levels were similar in the breast cyst fluid and plasma in both study groups. There was no correlation between corresponding levels of leptin, adiponectin, resistin, visfatin/NAMPT, TNF-α, and IL-6 in breast cyst fluid and plasma. Conclusions. Higher levels of visfatin/NAMPT and TNF-α in the fluid from simple and complex breast cysts than in plasma suggest that their local production is related to inflammation.
Department of Endocrinological Gynecology, Medical Faculty in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Paweł
P
Madej
Department of Endocrinological Gynecology, Medical Faculty in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Grzegorz
G
Franik
Department of Endocrinological Gynecology, Medical Faculty in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Piotr
P
Kurpas
Department of Statistics in Sosnowiec, Medical University of Silesia, 40-752 Katowice, Poland.
Aleksander
0000-0003-1179-6932
A
Owczarek
Pathophysiology Unit, Department of Pathophysiology, Medical Faculty in Katowice, Medical University of Silesia, 20-093 Katowice, Poland.
Jerzy
0000-0002-6367-7794
J
Chudek
Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical Faculty in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Magdalena
M
Olszanecka-Glinianowicz
D052242:Adiponectin / Q000378:metabolism*; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D047688:Breast Cyst / Q000378:metabolism / Q000473:pathology*; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism*; D009367:Neoplasm Staging; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism*; D011379:Prognosis; D011446:Prospective Studies; D052243:Resistin / Q000378:metabolism*; D015996:Survival Rate; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
C499918:ADIPOQ protein, human; D052242:Adiponectin; D014408:Biomarkers, Tumor; D016207:Cytokines; D015850:Interleukin-6; D020738:Leptin; C499624:RETN protein, human; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human