Combined deficiency of factor V and factor VIII: management during cardiothoracic surgery.
: Combined factor V and factor VIII deficiency is an extremely rare bleeding disorder for which research is lacking. We present the case of a 33-year-old man requiring repeat mitral valve replacement. A multidisciplinary team approach was utilized to minimize his risk of bleeding which included the use of plasma exchange, intravenous factor replacement, and platelet transfusion. This approach created an operative experience that did not require blood transfusion or the use of other hemostatic medications.
University of Kansas Hospital, Division of Hematology/Oncology, Kansas City, Kansas USA.
Christin
C
Howard
Brea
B
Lipe
D000328:Adult; D001780:Blood Coagulation Tests; D005166:Factor V Deficiency / Q000188:drug therapy*; D006467:Hemophilia A / Q000188:drug therapy*; D006801:Humans; D008297:Male; D013903:Thoracic Surgery / Q000379:methods*