Development of an ANN optimized mucoadhesive buccal tablet containing flurbiprofen and lidocaine for dental pain.
A novel mucoadhesive buccal tablet containing flurbiprofen (FLB) and lidocaine HCl (LID) was prepared to relieve dental pain. Tablet formulations (F1-F9) were prepared using variable quantities of mucoadhesive agents, hydroxypropyl methyl cellulose (HPMC) and sodium alginate (SA). The formulations were evaluated for their physicochemical properties, mucoadhesive strength and mucoadhesion time, swellability index and in vitro release of active agents. Release of both drugs depended on the relative ratio of HPMC:SA. However, mucoadhesive strength and mucoadhesion time were better in formulations, containing higher proportions of HPMC compared to SA. An artificial neural network (ANN) approach was applied to optimise formulations based on known effective parameters (i.e., mucoadhesive strength, mucoadhesion time and drug release), which proved valuable. This study indicates that an effective buccal tablet formulation of flurbiprofen and lidocaine can be prepared via an optimized ANN approach.
Amjad
A
Hussain
Muhammad Ali
MA
Syed
Nasir
N
Abbas
Sana
S
Hanif
Muhammad Sohail
MS
Arshad
Nadeem Irfan
NI
Bukhari
Khalid
K
Hussain
Muhammad
M
Akhlaq
Zeeshan
Z
Ahmad
D000268:Adhesiveness; D000278:Administration, Buccal; D000464:Alginates / Q000737:chemistry; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000737:chemistry*; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding; D005480:Flurbiprofen / Q000008:administration & dosage / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D065347:Hypromellose Derivatives / Q000737:chemistry; D007700:Kinetics; D008012:Lidocaine / Q000008:administration & dosage / Q000737:chemistry*; D008956:Models, Chemical; D009061:Mouth Mucosa / Q000737:chemistry*; D016571:Neural Networks, Computer; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*; D014098:Toothache / Q000517:prevention & control*
D000464:Alginates; D000779:Anesthetics, Local; D016861:Cyclooxygenase Inhibitors; D006603:Hexuronic Acids; D013607:Tablets; D065347:Hypromellose Derivatives; D005480:Flurbiprofen; D020723:Glucuronic Acid; D008012:Lidocaine