Study on Clinicopathological Features of Gastrointestinal Stromal Tumor and Relevant Prognostic Factors.
The objective of the study is to investigate and analyze clinicopathological features of gastrointestinal stromal tumor (GIST) and relevant prognostic factors. Between September 2008 and April 2014, 168 patients who presented with pathologically confirmed GIST and underwent surgical resection of the tumors in our institution were included in this study. A retrospective study on clinicopathological features of the disease and follow-up study on 1-year, 3-year, and 5-year survival rates were performed. Of 168 patients, 113 were males and 55 females of age ranging from 18 to 78 years (mean age 52.6 ± 10.1 years). Seventy patients (41.7 %) presented abdominal distension, 74 (44.0 %) abdominal pain, and 82 (48.8 %) bloody stools. Of all patients, 115 (68.4 %) developed tumors in GI tract, 51 (30.4 %) presented multiple tumors, 88 (52.4 %) tumors displayed a maximal diameter >5 cm, mitotic count >5/50HPF were observed in 80 patients. Positive rate of CD117 was 92.9 % (156/12), DOG1 97.0 % (163/5), CD34 53.0 % (89/79) and S-100 25.6 % (43/125). Follow-up study achieved in 149 patients. Survival analysis and Cox regression analysis demonstrated that no significant prognostic effects were observed for gender, clinical presentations, tumor location, number of tumors, CD34 and S-100 expression (p > 0.05). However, tumor diameter and mitotic count were factors with significant effect on prognosis of GIST (p < 0.05). Tumors with diameter >5 cm and mitotic count ≥5/50HPF resulted in poor prognosis. Common symptoms of GIST include abdominal pain and blood stools. Tumor diameter and mitotic count are helpful for the evaluation of prognosis with favorable clinical value.
Department of Pathology, Henan Provincial People's Hospital, Zhengzhou, China.
Qiuyu
Q
Liu
Department of Stomatology, Henan Provincial People's Hospital, Zhengzhou, China.
Yonggong
Y
Wang
Department of Pathology, Henan Provincial People's Hospital, Zhengzhou, China.
Lingfei
L
Kong
Department of Pathology, Henan Provincial People's Hospital, Zhengzhou, China. yunzhenkan@163.com.
Yunzhen
Y
Kan
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D018952:Antigens, CD34 / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D046152:Gastrointestinal Stromal Tumors / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019009:Proto-Oncogene Proteins c-kit / Q000097:blood; D009418:S100 Proteins / Q000097:blood; D012737:Sex Factors; D016019:Survival Analysis
D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D009418:S100 Proteins; D019009:Proto-Oncogene Proteins c-kit
CD117; Clinical features; Factor analysis; Gastrointestinal stromal tumor; Pathological features; Prognosis