Application of the Oral Minimal Model to Korean Subjects with Normal Glucose Tolerance and Type 2 Diabetes Mellitus.
BACKGROUND
The oral minimal model is a simple, useful tool for the assessment of β-cell function and insulin sensitivity across the spectrum of glucose tolerance, including normal glucose tolerance (NGT), prediabetes, and type 2 diabetes mellitus (T2DM) in humans.


METHODS
Plasma glucose, insulin, and C-peptide levels were measured during a 180-minute, 75-g oral glucose tolerance test in 24 Korean subjects with NGT (n=10) and T2DM (n=14). The parameters in the computational model were estimated, and the indexes for insulin sensitivity and β-cell function were compared between the NGT and T2DM groups.


RESULTS
The insulin sensitivity index was lower in the T2DM group than the NGT group. The basal index of β-cell responsivity, basal hepatic insulin extraction ratio, and post-glucose challenge hepatic insulin extraction ratio were not different between the NGT and T2DM groups. The dynamic, static, and total β-cell responsivity indexes were significantly lower in the T2DM group than the NGT group. The dynamic, static, and total disposition indexes were also significantly lower in the T2DM group than the NGT group.


CONCLUSIONS
The oral minimal model can be reproducibly applied to evaluate β-cell function and insulin sensitivity in Koreans.
Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea.
Min Hyuk
MH
Lim
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Tae Jung
TJ
Oh
Interdisciplinary Program of Bioengineering, Seoul National University College of Engineering, Seoul, Korea.
Karam
K
Choi
Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea.
Jung Chan
JC
Lee
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. ymchomd@snu.ac.kr.
Young Min
http://orcid.org/0000-0002-2331-6126
YM
Cho
Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea. sungwan@snu.ac.kr.
Sungwan
http://orcid.org/0000-0002-9318-849X
S
Kim
Computational method; Disposition index; Glucose tolerance test; Insulin resistance; Oral minimal model; Responsivity index