BMP signaling turns up in fragile X syndrome: FMRP represses BMPR2.
Fragile X syndrome is the most common inherited form of intellectual disability and results from a loss of function of the translational repressor FMRP. In this issue of Science Signaling, Kashima et al find that FMRP binds to and represses a specific isoform of BMPR2, a type II bone morphogenetic protein (BMP) receptor. Reducing signaling through this BMP pathway reverses neuroanatomical defects observed in fragile X models.
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. heather.broihier@case.edu.
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D052006:Bone Morphogenetic Protein Receptors, Type II; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics; D005600:Fragile X Syndrome; D005786:Gene Expression Regulation; D006801:Humans; D015398:Signal Transduction
D052006:Bone Morphogenetic Protein Receptors, Type II; D051860:Fragile X Messenger Ribonucleoprotein 1; C498218:BMPR2 protein, human