The Murky Life of Merkel Cell Polyomavirus.
Merkel cell polyomavirus (MCPyV) expressing viral T antigens is a common feature of most Merkel cell carcinomas, a primary neuroendocrine skin tumor. MCPyV has been difficult to propagate in vitro. In this issue of Cell Host & Microbe, Liu et al. (2016) report that human dermal fibroblasts support productive MCPyV infection.
Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA. Electronic address: dgallowa@fredhutch.org.
Denise A
DA
Galloway
D000957:Antigens, Viral, Tumor; D015266:Carcinoma, Merkel Cell; D004279:DNA, Viral; D006801:Humans; D059965:Merkel cell polyomavirus / Q000235:genetics*; D027601:Polyomavirus Infections; D014412:Tumor Virus Infections
D000957:Antigens, Viral, Tumor; D004279:DNA, Viral