Kidney transplant outcomes in familial C3 glomerulopathy.
C3 glomerulopathy, a newly designated entity, is characterized by glomerular disease associated with dysregulation of the alternative complement pathway and is a rare cause of end-stage kidney disease. Overall disease characteristics that include clinical presentation, laboratory assessment, histopathology and genetic background have only been unravelled in recent years and have led to the development of anti-complement therapies targeting different levels of the alternative pathway. We describe the long-term outcomes following kidney transplantation in an Irish family with familial C3 glomerulopathy due to a hybrid CFHR3-1 gene.
Department of Nephrology , Beaumont Hospital , Dublin , Ireland.
Limy
L
Wong
Department of Nephrology , Beaumont Hospital , Dublin , Ireland.
Sarah
S
Moran
Department of Nephrology , Tallaght Hospital , Dublin , Ireland.
Peter J
PJ
Lavin
Department of Renal Pathology, Beaumont Hospital, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland.
Anthony M
AM
Dorman
Department of Nephrology, Beaumont Hospital, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland.
Peter J
PJ
Conlon
complement; graft function; graft survival; kidney transplantation