Transcriptomics, proteomics and metabolomics driven biomarker discovery in COPD: an update.
Diagnosis of chronic obstructive pulmonary disease (COPD), characterized by progressive irreversible airflow limitation, remains a challenge. Lack of sensitive diagnostic markers and alternative treatments have limited patients' survival rate. Herein, we provide for clinicians and scientists a comprehensive review on the various omics platforms used to investigate COPD.



This review consists of articles from PubMed (2009-2016) as well as views of the contributing authors. The review highlights the need for COPD biomarker identification and also provides an update on promising candidate markers identified in various biological fluids using omics technologies. Expert commentary: The multi-omics approach holds promise for the development of robust early stage COPD diagnostic markers, screening of high-risk population, and also improved prognosis which could lead to personalized medicine in future. Various factors regulating an omics study including sample size, control selection, disease phenotyping, usage of complementary techniques and result replication in omics-based research are outlined.
a School of Medical Science and Technology , Indian Institute of Technology Kharagpur , Kharagpur , India.
Nilanjana
N
Ghosh
a School of Medical Science and Technology , Indian Institute of Technology Kharagpur , Kharagpur , India.
Mainak
M
Dutta
a School of Medical Science and Technology , Indian Institute of Technology Kharagpur , Kharagpur , India.
Brajesh
B
Singh
b Department of Agricultural & Food Engineering , Indian Institute of Technology Kharagpur , Kharagpur , India.
Rintu
R
Banerjee
c Department of Pulmonary medicine , Institute of Pulmocare and Research , Kolkata , India.
Parthasarathi
P
Bhattacharyya
a School of Medical Science and Technology , Indian Institute of Technology Kharagpur , Kharagpur , India.
Koel
K
Chaudhury
D015415:Biomarkers; D001826:Body Fluids / Q000378:metabolism; D016022:Case-Control Studies; D015897:Comorbidity; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D008168:Lung / Q000378:metabolism; D055432:Metabolomics / Q000379:methods; D011379:Prognosis; D040901:Proteomics / Q000379:methods; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy; D015203:Reproducibility of Results
D015415:Biomarkers
COPD; biomarkers; lipidomics; metabolomics; metabonomics; omics; proteomics; transcriptomics