[Antibacterial Activity of Alkylated and Acylated Derivatives of Low-Molecular Weight Chitosan].
A number of alkylated (quaternized) and acylated derivatives of low-molecular weight chitosan were obtained. The structure and composition of the compounds were confirmed by the results of IR and PMR spectroscopy, as well as conductometric titration. The effect of the acyl substituent and the degree of substitution of N-(2-hydroxy-3-trimethylammonium) with the propyl fragment appended to amino groups of the C2 atom of polymer chains on antibacterial activity against typical representatives of gram-positive and gram-negative microorganisms (Staphylococcus epidermidis and Escherichia coli) was studied. The highest activity was in the case of N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan chloride with the maximal substitution (98%). The minimal inhibitory concentration of the derivative was 0.48 µg/mL and 3.90 µg/mL for S. epidermis and E. coli, respectively.
B Ts
BTs
Shagdarova
A V
AV
Il'ina
V P
VP
Varlamov
D000215:Acylation; D000477:Alkylating Agents / Q000378:metabolism* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D048271:Chitosan / Q000378:metabolism* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D008970:Molecular Weight; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects
D000477:Alkylating Agents; D000900:Anti-Bacterial Agents; D048271:Chitosan