Osteopontin is elevated in patients with mitral annulus calcification independent from classic cardiovascular risk factors.
Osteopontin (OPN) regulates the Ca(++)-deposition in bone and coronary arteries. Elevated OPN were also associated with (aortic) valve calcification in healthy individuals. This study aimed to investigate the association between OPN levels and mitral annulus calcification (MAC) in patients with coronary artery disease (CAD).



In this cross-sectional study OPN-levels were measured in 223 non-or ex-smoking patients (160 male, mean age: 61,09 ± 11,02 years; 63 female: mean age: 67,49 ± 7,87 years) with CAD. Plasma OPN levels were measured by ELISA and MAC was evaluated by echocardiography.



Forward stepwise logistic regression analysis (likelihood quotient) showed significantly higher OPN-levels in patients with MAC compared to patient without calcified mitral annulus independent from the classic risk factors age and severity of coronary artery disease (CAD). In addition to age and the severity of CAD, the circulating OPN amount was a significant predictor for MAC.



This is the first clinical trial which observed increased circulating OPN levels in MAC, suggesting a distinct role of OPN in the process of MAC. Considering the current knowledge about OPN it is more likely that OPN does not promote but counteracts valve calcification and therefore is elevated in course of a calcification processes.
Department of Cardiology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. michael.sponder@meduniwien.ac.at.
Michael
0000-0001-9016-2975
M
Sponder
Department of Anesthesiology and Operative Intensive Care Medicine, University Hospital of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany.
Christian
C
Reuter
Department of Medical-Chemical Laboratory Analysis, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Monika
M
Fritzer-Szekeres
Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Brigitte
B
Litschauer
Department of Cardiology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Thomas
T
Binder
Department of Cardiology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Jeanette
J
Strametz-Juranek
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002114:Calcinosis / Q000097:blood* / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D023921:Coronary Stenosis / Q000097:blood* / Q000000981:diagnostic imaging; D003430:Cross-Sectional Studies; D004452:Echocardiography; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood* / Q000000981:diagnostic imaging; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood*; D012307:Risk Factors; D012720:Severity of Illness Index; D015854:Up-Regulation
D015415:Biomarkers; C506895:SPP1 protein, human; D053495:Osteopontin
Atherosclerosis; Coronary artery disease; Mitral annulus calcification; Osteopontin