Thrombophilia in Korean patients with arterial or venous thromboembolisms.
OBJECTIVE
To determine the prevalence of thrombophilia in Korean patients with an arterial thromboembolism (ATE) or a venous thromboembolism (VTE), and to evaluate the characteristic of VTE in patients with thrombophilia.


METHODS
Hospital records of 294 patients (228 with VTE, 66 with ATE) including two foreign ones (mean age, 51.4 years) who underwent thrombophilia testing between August 2006 and March 2015 were reviewed retrospectively. In general, such screening was performed according to the guidelines of the international consensus statement for VTE. Thrombophilia testing included evaluations of the factor V Leiden and prothrombin G20210A mutations, levels of proteins C and S and antithrombin, and antiphospholipid antibody syndrome (APLS).


RESULTS
A factor V Leiden mutation was not found in the 292 Korean patients. A prothrombin G21210A mutation was investigated in 33 patients but none was found. Among 226 Korean patients with VTE, 130 demonstrated no thrombophilia and 55 patients did after exclusion of 41 patients without confirmatory test. The most common form was protein S deficiency (31 of 55, 56%) followed by protein C deficiency, antithrombin deficiency, and APLS. When comparing patients with a VTE or deep vein thrombosis (DVT) according to the presence of thrombophilia, thrombophilia was associated with younger age (P = 0.001 for VTE; P < 0.001 for DVT) and a family history (P < 0.001 for VTE and DVT).


CONCLUSIONS
We did not find any factor V Leiden mutation in Korean subjects at high risk for thrombophilia. Therefore, this testing is not warranted. Thrombophilia was associated with VTE in younger age and a family history.
Division of Vascular Surgery, Department of Surgery, Kyungpook National University School of Medicine, Daegu, Korea.
Sungbae
S
Kim
Division of Vascular Surgery, Department of Surgery, Kyungpook National University School of Medicine, Daegu, Korea.
Incheol
I
Song
Division of Vascular Surgery, Department of Surgery, Kyungpook National University School of Medicine, Daegu, Korea.
Hyung-Kee
HK
Kim
Division of Vascular Surgery, Department of Surgery, Kyungpook National University School of Medicine, Daegu, Korea.
Seung
S
Huh
Korea; Thrombophilia; Venous thromboembolism; Venous thrombosis