Solid state drug-polymer miscibility studies using the model drug ABT-102.
Amorphous solid dispersions typically suffer storage stability issues due to: their amorphous nature, high drug loading, uneven drug:stabilizer ratio and plasticization effects as a result of hygroscopic excipients. An extensive solid state miscibility study was conducted to aid in understanding the mechanisms involved in drug/stabilizer interactions. ABT-102 (model drug) and nine different polymers with different molecular weights and viscosities were selected to investigate drug/polymer miscibility. Three different polymer:drug ratios (1:3, 1:1 and 3:1, w/w) were analyzed using: DSC, FTIR and PXRD. Three different techniques were used to prepare the amorphous solid dispersions: serial dilution, solvent evaporation and spray drying. Spray drying was the best method to obtain amorphous solid dispersions. However, under certain conditions amorphous formulations could be obtained using solvent evaporation. Melting point depression was used to calculate interaction parameters and free energy of mixing for the various drug polymer mixtures. The spray dried solid dispersions yielded a negative free energy of mixing which indicated strong drug-polymer miscibility compared to the solvent evaporation and serial dilution method. Soluplus was the best stabilizer compared to PVP and HPMC, which is probably a consequence of strong hydrogen bonding between the two CO moieties of soluplus and the drug NH moieities.
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, United States.
Rajan
R
Jog
Global Pharmaceutical R&D, AbbVie Pte. Ltd., 138667, Singapore.
Rajeev
R
Gokhale
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, United States. Electronic address: diane.burgess@uconn.edu.
Diane J
DJ
Burgess
D002626:Chemistry, Pharmaceutical / Q000379:methods; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D007191:Indazoles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry
C528492:ABT 102; D005079:Excipients; D007191:Indazoles; D011108:Polymers; D012997:Solvents; D014508:Urea
Amorphous solid dispersion; Interaction; Miscibility; Solid-state; Spray drying; Thermodynamics