Protein Z G79A polymorphism in Turkish pediatriccerebral infarct patients.
Protein Z (PZ) plays an enhancer role in coagulation as an anticoagulant. This is the first study in which G79A polymorphism investigated in Turkish paediatric stroke patients. Ninety-one paediatric stroke patients with cerebral ischemia and 70 control subjects were analyzed for PZ G79A and also FVL, PT mutations. PZ 79 'A' allele in homozygous state was found in five patients (5,5%), while it was found only in one control subject (1,4%) and it was seemed as a risk factor for peadiatric ischemia [OR=3,94 (0,44-35,1)]. When patients and controls who had FVL and PT carriers were excluded, AA genotype carried a risk [OR=3,88 (0,41-36,5)]. Also plasma protein Z levels measured in 21 stroke patients and 52 controls. Plasma protein Z levels were not different between stroke patients (500,95 ngmL-1±158,35) and controls (447,34 ngmL-1±165,97). But the plasma levels of protein Z was decreased in patients with AA genotype. Our data showed that carrying 79 AA genotype could be a genetic risk factor for cerebral infarct in peadiatric patients.
Ayşenur
A
Öztürk
Yonca
Y
Eğin
Gülhis
G
Deda
Serap
S
Teber
Ankara University Medical School, Department of Pediatric Molecular Genetic, 06610 Cebeci Ankara, Turkey, Phone: +90 312 362 30 30/6348 E-mail:akar@medicine.ankara.edu.tr.
Nejat
N
Akar