Development of a Certified Reference Material for myeloperoxidase-anti-neutrophil cytoplasmic autoantibodies (MPO-ANCA).
A serum Certified Reference Material (CRM) for supporting reliable autoimmune diagnostics was recently released by the Institute for Reference Materials and Measurements (IRMM) of the Joint Research Centre of the European Commission. It was produced in collaboration with a Working Group on the Harmonisation of Autoimmune Tests of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC WG-HAT). This material is aimed at facilitating the standardisation of measurements of anti-myeloperoxidase immunoglobulin G antibodies. The CRM could be used as a common calibrant by clinicians and manufacturers thereby significantly improving the comparability of results from commercial immunoassays used for IgG anti-MPO measurements. This paper provides information on the new CRM and its intended use.
European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel, Belgium.
Evanthia
E
Monogioudi
European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel, Belgium.
Dana Petronela
DP
Hutu
European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel, Belgium.
Gustavo
G
Martos
Protein Reference Unit and Immunopathology Department, St Georges' Hospital, London, United Kingdom.
Joanna
J
Sheldon
European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel, Belgium.
Heinz
H
Schimmel
Department of Clinical Sciences and Community Health & Istituto Auxologico Italiano, Milan, Italy.
Pier Luigi
PL
Meroni
European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel, Belgium.
Ingrid
I
Zegers
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis* / Q000276:immunology; D001327:Autoimmune Diseases / Q000175:diagnosis; D019963:Clinical Chemistry Tests / Q000592:standards*; D006801:Humans; D009195:Peroxidase / Q000276:immunology*; D012015:Reference Standards
D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase
Certified reference material; Myeloperoxidase; Standardisation; Vasculitis