Psychopharmacological Effects of Alkaloid Z77 under Conditions of Posthypoxic Encephalopathy and Mechanisms of Their Development.
Psychopharmacological effects of atisine-type diterpene alkaloid Z77 were studied under conditions of experimental posthypoxic encephalopathy. The preparation had a pronounced cerebroprotective effect consisting in normalization of orientation and exploratory behavior and conditioned activity in experimental animals. These changes were accompanied by significant increase in the number of neural stem cells in the paraventricular region of the brain and markedly enhanced production of neurotrophic growth factors by neural tissue microenvironment cells.
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. zgn@pharm.tsu.ru.|Tomsk National Research State University, Tomsk, Russia. zgn@pharm.tsu.ru.
G N
GN
Zyuz'kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
E A
EA
Losev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
A V
AV
Chaikovskii
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
N I
NI
Suslov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
V V
VV
Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
E V
EV
Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
L A
LA
Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
E V
EV
Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
T Yu
TY
Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
T N
TN
Povet'eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
Yu V
YV
Nesterova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
L A
LA
Stavrova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.|Tomsk National Research State University, Tomsk, Russia.
V V
VV
Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
M Yu
MY
Minakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
A M
AM
Dygai
D000470:Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use*; D000818:Animals; D001921:Brain / Q000187:drug effects; D001927:Brain Diseases / Q000188:drug therapy*; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D051379:Mice; D058953:Neural Stem Cells / Q000187:drug effects; D044968:Regenerative Medicine
D000470:Alkaloids
alkaloids; cerebroprotective preparations; hypoxia; neural stem cells; regenerative medicine