Secondary Acquired Cholesteatoma: Presentation and Tympanoplasty Outcomes.
Comparing the clinical features and surgical outcomes of patients undergoing tympanoplasty for secondary acquired cholesteatoma (SAC) versus non-complicated tympanic membrane perforation (TMP).



Retrospective patient review.



Tertiary-care, academic center.



All 41 patients with diagnosis of SAC confirmed at surgery between January 1, 2007 and June 30, 2014, and an age-matched cohort consisting of patients with TMP.



Tympanoplasty using either medial or lateral graft techniques.



Resolution of perforation, SAC, and symptoms.



Comparison between the two cohorts failed to reveal significant differences in otologic symptomology, or presentation. There was no significant difference in the resolution of SAC (p = 0.7) between the medial and lateral tympanoplasty techniques. Both techniques also had similar rates of success in the TMP cohort. The medial graft technique was significantly (p = 0.008) more likely to result in a successfully repaired tympanic membrane in the TMP cohort compared with the SAC cohort. The Lateral graft technique demonstrated no significant difference in the likelihood of TMP and SAC resolution.



The presentation of SAC is similar to that of TMP despite being a separate clinical entity. A clinician's ability to distinguish the two is important to mitigate the destructive potential of untreated SAC and correctly council patients on tympanoplasty success rates. This study was unable to demonstrate a significant difference in disease control between the medial and lateral tympanoplasty techniques, although potential advantages of each technique are discussed.
*Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland †Department of Otolaryngology, University of the West Indies, Kingston, Jamaica, West Indies.
James H
JH
Clark
Allen
A
Feng
Aisha
A
Harun
Glendine
G
Brown
Howard W
HW
Francis
D000328:Adult; D016022:Case-Control Studies; D018424:Cholesteatoma, Middle Ear / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D018058:Tympanic Membrane Perforation / Q000601:surgery; D014433:Tympanoplasty / Q000379:methods*