Nanotechnology and Nanopore Sequencing.
DNA sequencing is one of the crucially important tasks in the fields of genetics and cellular biology, which is benefiting from nanotechnology. DNA carries genetic information and sequencing it in a quick way helps researchers in achieving essential goals, including personalized medicine. Solid state nanopores potentially can offer more durability, in sequencing biomolecules, over the proteinbased nanopores. In recent years, various ideas are introduced towards the goal of fast and low cost sequencing. In this review article recent advances presented in journal articles as well as patents in this field, including sequencing methods, membrane materials and their fabrication techniques, drilling methods, and biomolecule translocation speed control ideas are investigated.
Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, United States.
Roozbeh
R
Abedini-Nassab
D004247:DNA / Q000737:chemistry*; D058608:Nanopores / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D010330:Patents as Topic; D011789:Quantum Theory; D017422:Sequence Analysis, DNA; D014173:Transistors, Electronic
D004247:DNA
Genomics; ionic current blockade; membrane drilling techniques; nanotechnology; sequencing; solid state nanopore