Effects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Genes.
A group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT-29, MCF-7, and HeLa) and one non-tumoral human cell line (HEK-293). The values obtained were compared with those of curcumin. A subset of selected derivatives was also studied for their ability to downregulate expression of the hTERT and c-Myc genes, which are both involved in telomerase activity.
Departamento de Química Inorgánica y Orgánica, Universidad Jaume I, Castellón, Spain.
Rosa
R
Martí-Centelles
Departamento de Química Inorgánica y Orgánica, Universidad Jaume I, Castellón, Spain.
Eva
E
Falomir
Departamento de Química Inorgánica y Orgánica, Universidad Jaume I, Castellón, Spain.
Miguel
M
Carda
Facultad de Ciencias, Departamento de Química Orgánica y Bio-Orgánica, UNED, Madrid, Spain.
Carla I
CI
Nieto
Facultad de Ciencias, Departamento de Química Orgánica y Bio-Orgánica, UNED, Madrid, Spain.
M Pilar
MP
Cornago
Facultad de Ciencias, Departamento de Química Orgánica y Bio-Orgánica, UNED, Madrid, Spain.
Rosa M
RM
Claramunt
D045744:Cell Line, Tumor; D002478:Cells, Cultured; D003474:Curcumin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D015536:Down-Regulation / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis / Q000235:genetics; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D019098:Telomerase / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism
C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D011720:Pyrazoles; C509186:TERT protein, human; D019098:Telomerase; D003474:Curcumin
Curcuminoid pyrazoles; Cytotoxicity; Gene downregulation; Telomerase