Chemotherapy-Induced Neurotoxicity: Evidence of a Protective Role of CC Homozygosis in the Interleukin-1β Gene-511 C>T Polymorphism.
We hypothesized that the IL-1β-511 C>T polymorphism could be associated with the development of neurotoxicity and that it could be a possible biomarker to rate the risk of occurrence of neurotoxicity in cancer patients. Genomic DNA was extracted from 85 cancer patients: 49 received systemic chemotherapeutic treatment (CHT) and 36 patients did not receive it (No-CHT). All subjects were genotyped for the functionally active polymorphisms of IL-1β-511 C>T. We estimated neurotoxicity with the evaluation of neurological deficits. CHT patients showed erythrocytopenia, neurological deficit and a slight lowering of cognitive performance. The subgroup of patients carrying the CC genotype of the IL-1β-511 C>T gene showed lesser neurological deficits. In the context of cancer treatment, we suggested the potential value of IL-1β-511 C>T as genetic biomarkers to identify patients with higher risk to develop neurological deficits.
Department of Neuroscience, AOU San Giovanni Battista, Turin, Italy.
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E
Peila
Department of Neuroscience, AOU San Giovanni Battista, Turin, Italy. federico.dagata@unito.it.
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F
D'Agata
Department of Neuroscience, AOU San Giovanni Battista, Turin, Italy.|IRCCS Fondazione Istituto Neurologico Carlo Besta, Milan, Italy.
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Caroppo
Department of Neuroscience, AOU San Giovanni Battista, Turin, Italy.
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L
Orsi
Department of Neuroscience, AOU San Giovanni Battista, Turin, Italy.
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P
Mortara
Nuclear Medicine, AOU San Giovanni Battista, Turin, Italy.
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Cauda
Nuclear Medicine, AOU San Giovanni Battista, Turin, Italy.
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M
Manfredi
Department of Neuroscience, AOU San Giovanni Battista, Turin, Italy.
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MM
Caglio
Department of Neuroscience, AOU San Giovanni Battista, Turin, Italy.
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Fenoglio
Nuclear Medicine, AOU San Giovanni Battista, Turin, Italy.
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B
Baudino
Nuclear Medicine, AOU San Giovanni Battista, Turin, Italy.
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Castellano
Nuclear Medicine, AOU San Giovanni Battista, Turin, Italy.
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G
Bisi
Department of Neuroscience, AOU San Giovanni Battista, Turin, Italy.
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L
Pinessi
Department of Neuroscience, AOU San Giovanni Battista, Turin, Italy.
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S
Gallone
D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006720:Homozygote; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy / Q000235:genetics; D009483:Neuropsychological Tests; D020258:Neurotoxicity Syndromes / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D000970:Antineoplastic Agents; C508585:IL1B protein, human; D053583:Interleukin-1beta
Cancer; Chemotherapy; Cytokines; IL-1β; Neurotoxicity