Risk of second primary cancers after malignant mesothelioma and vice versa.
We aimed at investigating risk of specific second primary cancers (SPCs) after malignant mesothelioma (MM) and vice versa, which has not been reported. Among survivors of 3672 pleural MM and 895 peritoneal MM, overall 113 and 28 SPCs were recorded, respectively, while reverse analyses included overall 431 pleural and 88 peritoneal MMs after any first cancers. We found a bidirectional association of pleural MM with kidney cancer for overall [for second kidney cancer after pleural MM: standardized incidence ratios (SIRs) = 4.4, 95% confidence intervals (CIs): 2.0-8.3; for second pleural MM after kidney cancer: 2.3 (1.3-3.9)] and for <1 year follow-up [5.4 (2.0-12) and 4.9 (2.0-10), respectively, according to the 2-way analyses]. In contrast, a bidirectional association of pleural MM with unknown primary cancer was found only for follow-up ≥1 year [3.9 (1.1-10) and 2.8 (1.3-5.1), respectively]. We found a bidirectional association of pleural MM with kidney cancer for overall and for <1 year follow-up, suggesting the involvement of germline BAP1 mutations and increased medical surveillance, while the bidirectional association of pleural MM with unknown primary cancer suggests shared genetic or environmental risk factors.
Group of Molecular Epidemiology & Cancer Precision Prevention, Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou, China; Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: t.chen@zjams.com.cn.
Tianhui
T
Chen
Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Elham
E
Kharazmi
Group of Molecular Epidemiology & Cancer Precision Prevention, Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou, China.
Jianlin
J
Lou
Group of Molecular Epidemiology & Cancer Precision Prevention, Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou, China.
Xing
X
Zhang
Center for Primary Health Care Research, Lund University, Malmö, Sweden; Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA 94305-5705, USA.
Kristina
K
Sundquist
Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA 94305-5705, USA.
Kari
K
Hemminki
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004777:Environment; D005260:Female; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D008297:Male; D008654:Mesothelioma / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D010641:Phenotype; D010997:Pleural Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D013997:Time Factors; D025521:Tumor Suppressor Proteins / Q000235:genetics; D043222:Ubiquitin Thiolesterase / Q000235:genetics; D055815:Young Adult
C400134:BAP1 protein, human; D025521:Tumor Suppressor Proteins; D043222:Ubiquitin Thiolesterase
Cancer registry; Etiology; Malignant mesothelioma; Peritoneal mesothelioma; Pleural mesothelioma; Second primary cancers