Fungal meningitis caused by Lomentospora prolificans after allogeneic hematopoietic stem cell transplantation.
Central nervous system lomentosporiosis is a rare pathological condition in immunocompromised patients. We describe a fatal case of meningitis caused by Lomentospora prolificans (which was previously named Scedosporium prolificans), after an allogeneic hematopoietic stem cell transplantation (allo-HSCT). To our knowledge, no cases of Lomentospora meningitis following allo-HSCT have been reported previously. Particularly in neutropenic patients, it is important to consider L. prolificans when a fungal infection is suspected and antifungal agents are ineffective.
Department of Hematology, Sumitomo Hospital, Osaka, Japan.
M
M
Tamaki
Department of Hematology, Sumitomo Hospital, Osaka, Japan.
K
K
Nozaki
Department of Hematology, Sumitomo Hospital, Osaka, Japan.
M
M
Onishi
Department of Hematology, Sumitomo Hospital, Osaka, Japan.
K
K
Yamamoto
Department of Hematology, Sumitomo Hospital, Osaka, Japan.
H
H
Ujiie
Department of Hematology, Sumitomo Hospital, Osaka, Japan.
H
H
Sugahara
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D017809:Fatal Outcome; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use; D006086:Graft vs Host Disease / Q000188:drug therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000473:pathology / Q000601:surgery; D008297:Male; D008578:Meninges / Q000473:pathology; D016921:Meningitis, Fungal / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000382:microbiology*; D008875:Middle Aged; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use; D021681:Scedosporium / Q000302:isolation & purification*; D016559:Tacrolimus / Q000009:adverse effects / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011239:Prednisolone; D016559:Tacrolimus
Lomentospora prolifican; Scedosporium prolificans; lomentosporiosis; meningitis; mold; stem cell transplant