Efficient transmembrane anion transport mediated by a bis(imidazolyl)-functionalized bis(choloyl) conjugate.
A bis(imidazolyl)-functionalized bis(choloyl) conjugate was synthesized and assessed for its transmembrane anionophoric activity by means of chloride ion selective electrode technique and pyranine assays. The results indicate that under the assay conditions, this conjugate was capable of mediating the symport of proton and anions, presumably via a channel mechanism. In addition, this compound was found to exhibit much higher anionophoric activity than the analogue without imidazolyl groups, revealing the significant role of the imidazolyl groups in the anion transport process.
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Zhi
Z
Li
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Li-Qun
LQ
Deng
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Yun
Y
Chen
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Tao
T
Wu
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China. Electronic address: whchen@smu.edu.cn.
Wen-Hua
WH
Chen
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002645:Chickens; D002712:Chlorides / Q000737:chemistry / Q000378:metabolism*; D002793:Cholic Acids / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology*; D017136:Ion Transport / Q000187:drug effects*; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D002712:Chlorides; D002793:Cholic Acids; D007093:Imidazoles; D008081:Liposomes; C029899:imidazole
Anion transporter; Anionophoric activity; Cholic acid; Imidazole