Evaluation of ceruloplasmin levels in patients with lumbar disc herniation.
Chronic inflammation is believed to have a role in the development of lumbar disc herniation (LDH). Ceruloplasmin (CP), an acute phase protein, is known to limit inflammation.
To evaluate CP levels in patients with LDH.
Thirty-five patients with LDH and 35 healthy individuals were enrolled in the study. Participants were divided into two groups; group 1 (n = 35) consisted of patients with LDH, and group 2 (n = 35) consisted of healthy subjects. Surgery specimens were taken from all patients who underwent LDH-related surgery. CP levels were measured in both blood and tissue samples. Pain intensity was evaluated using a visual analog scale (VAS).
There were no significant differences in gender, age, or body mass index between the control and LDH patients (p > 0.05 for all). Compared with the control patients, LDH patients had significantly higher serum CP levels (p < 0.001). In LDH patients, tissue CP levels were significantly higher than serum levels (p < 0.001). According to bivariate analysis, the serum CP levels were significantly correlated with the VAS score in group 1 (r = 0.491, p = 0.003).
The present study showed that CP levels increased in both the serum and the tissues of patients with LDH compared to patients without LDH, possibly as a consequence of LDH-associated inflammation.
Department of Neurosurgery, Harran University Faculty of Medicine, Sanliurfa, Turkey.
Hamza
H
Karabag
Department of Physical Medicine and Rehabilitation, Harran University Faculty of Medicine, Sanliurfa, Turkey.
Alparslan
A
Yetisgin
Department of Clinical Biochemistry, Harran University Faculty of Medicine, Sanliurfa, Turkey.
Emin
E
Savik
Department of Neurosurgery, Malatya State Hospital, Malatya, Turkey.
Mustafa
M
Kilic
Department of Physical Medicine and Rehabilitation, Harran University Faculty of Medicine, Sanliurfa, Turkey.|Department of Physical Medicine and Rehabilitation, Nusaybin State Hospital, Mardin, Turkey.
Rifat
R
Aridici
Department of Clinical Biochemistry, Harran University Faculty of Medicine, Sanliurfa, Turkey.
Abdullah
A
Taskin
Department of Internal Medicine, Harran University Faculty of Medicine, Sanliurfa, Turkey.
Turgay
T
Ulas
Ceruloplasmin; inflammation; lumbar disc herniation