Incidence and risk factors of bacterial infections in children following autologous hematopoietic stem cell transplantation: Single-center experience from Jordan.
Bacterial infection is a serious sequela following AHSCT; however, limited data are available regarding pediatric recipients, especially in developing countries. We retrospectively analyzed the incidence and risk factors of bacterial infections during the first 100 days after AHSCT in children at KHCC in Amman, Jordan between January, 2005 and September, 2013. A total of 65 patients were identified, with median age of four yr (1-17). Forty-seven patients (72.3%) had solid tumors and 18 (27.7%) had lymphoma. Bacterial infections were documented in 33 patients (50%), with a total of 63 episodes. Gram-negative infection (57.1%) was more prevalent than Gram-positive infection (38%). The risk of bacterial infections was higher among patients less than five yr of age (p = 0.028) and those who developed hypogammaglobulinemia requiring IVIG replacement (p = 0.001). Patients with solid tumors developed more bacterial infections compared to patients with lymphoma (p = 0.0057). No deaths were attributed to bacterial infection. Bacterial infection rate is high among recipients of AHSCT in Jordan with Gram-negative bacteria being the most common.
Bone Marrow and Stem Cell Transplantation Program, King Hussein Cancer Center, Amman, Jordan.
Ayad Ahmed
AA
Hussein
Bone Marrow and Stem Cell Transplantation Program, King Hussein Cancer Center, Amman, Jordan.
Eman T
ET
Al-Antary
Department of Pharmacy, King Hussein Cancer Center, Amman, Jordan.
Rula
R
Najjar
Bone Marrow and Stem Cell Transplantation Program, King Hussein Cancer Center, Amman, Jordan.
Abdulhadi
A
Al-Zaben
Pediatric Stem Cell Transplant Program, TriStar Children's Hospital and Sarah Cannon Research Institute, Nashville, TN, USA.
Haydar
H
Frangoul
D000293:Adolescent; D001424:Bacterial Infections / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007223:Infant; D007597:Jordan; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D014182:Transplantation, Autologous
autologous Hematopoietic stem cell transplantation; bacterial infection; children