The G allele in IL-10-1082 G/A may have a role in lowering the susceptibility to panic disorder in female patients.
BACKGROUND
Immune system activation is involved in the pathophysiology of panic disorder (PD). We investigated INF-γ+874 A/T, TNF-α-308 G/A, and IL-10-1082 G/A single nucleotide polymorphisms (SNPs) to determine their association with PD.


METHODS
This study enroled 135 PD patients and 135 healthy controls. INF-γ+874 A/T (rs2430561), TNF-α-308 G/A (rs1800629), and IL-10-1082 G/A (rs1800896) were genotyped.


RESULTS
There were no differences in genotypes or allele frequencies between the patient and control groups, regardless of accompanying agoraphobia. However, for female patients, the G allele frequency in IL-10 SNP was higher in the control group than in the patient group. Additionally, the female control group had a higher frequency of the A/G and G/G genotype in the IL-10 SNP than the female patient group.


CONCLUSIONS
We suggest that the G allele in IL-10-1082 G/A might have a role in reducing the manifestations of PD in female patients. Further studies are needed to extend and confirm our findings.
Department of Psychiatry,College of Medicine,Korea University,Seoul,Republic of Korea.
Han-Joon
HJ
Kim
Department of Psychiatry,College of Medicine,Korea University,Seoul,Republic of Korea.
Yong-Ku
YK
Kim
D000328:Adult; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D018836:Inflammation Mediators; D007371:Interferon-gamma / Q000235:genetics; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D016584:Panic Disorder / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
C508609:IL10 protein, human; D018836:Inflammation Mediators; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma
IFN-r; IL-10; TNF-α; cytokine; panic disorder