Ghrelin, insulin-like growth factor I and adipocytokines concentrations in born small for gestational age prepubertal children after the catch-up growth.
BACKGROUND
In children born small for gestational age (SGA) with catch-up growth, a higher risk of insulin resistance (IR) and cardiovascular diseases is noted. Ghrelin stimulates a growth hormone (GH) secretion and regulates lipid and carbohydrate metabolism. We assessed gherlin's influence on achieving normal height and the occurrence of metabolic complications in SGA children.


METHODS
Ghrelin, insulin-like growth factor type I (IGF-I), leptin, adiponectin, resistin, glucose, insulin and lipid concentrations were analysed in 134 prepubertal children in four groups: normal-height SGA, short SGA, normal-height born appropriate for gestational age (AGA) and short AGA.


RESULTS
Ghrelin and IGF-I concentrations were significantly higher while adiponectin - lower in normal-height SGA comparing to others.


CONCLUSIONS
The increased production of ghrelin and IGF-I seems to be an adaptive mechanism to achieve normal growth in SGA children. The significance of high ghrelin and low adiponectin concentrations, observed in normal-height prepubertal SGA children, requires elucidation, with reference to the development of metabolic complications.
Renata
R
Stawerska
Małgorzata
M
Szałapska
Maciej
M
Hilczer
Andrzej
A
Lewiński
D054392:Adipokines / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D001827:Body Height; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D054439:Ghrelin / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000254:growth & development* / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D011379:Prognosis; D012741:Sexual Maturation
D054392:Adipokines; D015415:Biomarkers; D054439:Ghrelin; D007334:Insulin-Like Growth Factor I