Treatment of agitation in the acute psychiatric setting. An observational study of the effectiveness of intramuscular psychotropic medication.
BACKGROUND
Agitation is frequent in the acute psychiatric setting. The observation and treatment of agitation is important to avoid harm to patients or staff, to reduce distress of the patient, and to reduce the risk of coercion, especially physical restraint.


OBJECTIVE
To evaluate the effect of intramuscular treatment with psychotropics on agitation in a non-selected acute psychiatric population.


METHODS
The Positive and Negative Syndrome Scale Excitement Component (PANSS-EC) was implemented in the acute psychiatric ward at Psychiatric Center Copenhagen to improve assessment and treatment of agitation. During a period of almost ~2 years the staff was requested to assess agitation before and after administration of intramuscular injections.


RESULTS
PANSS-EC was obtained at baseline and within 2 hours after injection for 135 injections with antipsychotics or benzodiazepines administered to 101 acute, non-selected psychiatric patients with high occurrence of co-morbid substance abuse. Mean PANSS-EC at baseline was 26.53 ± 4.87, and mean reduction in PANSS-EC was 14.99 ± 8.48 (p < 0.001). For 73% of injections PANSS-EC decreased with ≥40% (generally accepted definition of response). In 49% of cases patients were subjected to physical restraint. Patients subjected to restraint had a significantly higher PANSS-EC score. Patients who received a subsequent injection had a significantly lower decline in PANSS-EC score. Besides two cases of acute dystonia following haloperidol injections, no serious side-effects were observed.


CONCLUSIONS
Treatment of agitation with intramuscular injections of psychotropics was in general effective in this non-selected, highly agitated psychiatric population, and injections were well tolerated.
a Psychiatric Center Copenhagen , Copenhagen , Denmark ;
Jeanett Østerby
JØ
Bauer
a Psychiatric Center Copenhagen , Copenhagen , Denmark ;
Dina
D
Stenborg
a Psychiatric Center Copenhagen , Copenhagen , Denmark ;
Tue
T
Lodahl
b Technical University of Denmark , Lyngby , Denmark.
Mik Mathias
MM
Mønsted
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D011567:Psychiatric Department, Hospital / Q000639:trends; D011569:Psychiatric Status Rating Scales; D011595:Psychomotor Agitation / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome; D055815:Young Adult
D014150:Antipsychotic Agents; D006220:Haloperidol
Agitation; IM; PANSS-EC; antipsychotics; benzodiazepines