Statins and IL-1β, IL-10, and MPO Levels in Gingival Crevicular Fluid: Preliminary Results.
Statins possess a wide variety of pleiotropic properties that are independent of their lipid-lowering abilities such as attenuating inflammation, oxidative stress, coagulation, platelet aggregation and stimulating bone formation. The aim of the study is to evaluate the effect of statins on clinical periodontal parameters and gingival crevicular fluid (GCF) levels of IL-1β, IL-10, and myeloperoxidase (MPO) in inflammatory periodontal diseases. Seventy-nine subjects with hyperlipidemia and 48 systemically healthy controls (C) were included. Hyperlipidemic patients were either given a diet (HD) or prescribed statin (HS). Patients were classified into three subgroups as those who were periodontally healthy (h), who had gingivitis (g), or who had chronic periodontitis (p). Blood samples were collected for the measurement of lipid profiles. Plaque index (PI), gingival index (GI), probing pocket depth (PD), clinical attachment level (CAL), and percentage of bleeding on probing (BOP) were recorded. Gingival crevicular fluid levels of IL-1β, IL-10, and MPO were measured in order to determine the anti-inflammatory and antioxidant effects of statins. Probing depth values of the HSp group were significantly lower than those of the Cp group. Percentage of BOP of the HSg group was significantly lower than those of the HDg and Cg groups. While the IL-1β level of the HSp group was significantly lower than that of the HDp group, IL-10 levels of the HSg group were significantly higher than those of the HDg group. MPO levels were significantly lower in the HSg group when compared to those in the HDg and Cg groups. Statin use decreased the IL-1β and MPO levels and enhanced IL-10 in GCF. It can be suggested that statins may attenuate periodontal inflammation and progression of periodontal inflammation.
Department of Periodontology, Faculty of Dentistry, Hacettepe University, 3rd Floor, Sihhiye, 06100, Ankara, Turkey.
Vuslat
V
Cicek Ari
Department of Periodontology, Faculty of Dentistry, Hacettepe University, 3rd Floor, Sihhiye, 06100, Ankara, Turkey. ydy@hacettepe.edu.tr.
Yagmur Deniz
YD
Ilarslan
Pediatric Immunology Division, Ihsan Doğramacı Children's Hospital, Hacettepe University, Ankara, Turkey.
Baran
B
Erman
Scientific Industrial and Technological Application and Research Center, Abant Izzet Baysal University, Bolu, Turkey.
Bahram
B
Sarkarati
Pediatric Immunology Division, Ihsan Doğramacı Children's Hospital, Hacettepe University, Ankara, Turkey.
Ilhan
I
Tezcan
Department of Biostatistics, School of Medicine, Hacettepe University, Ankara, Turkey.
Erdem
E
Karabulut
Department of Internal Medicine, Faculty of Medicine, Section of General Internal Medicine, Hacettepe University, Ankara, Turkey.
Serife Gul
SG
Oz
Department of Internal Medicine, Faculty of Medicine, Section of General Internal Medicine, Hacettepe University, Ankara, Turkey.
Mine Durusu
MD
Tanriover
Department of Periodontology, Faculty of Dentistry, Hacettepe University, 3rd Floor, Sihhiye, 06100, Ankara, Turkey.
Dilek
D
Sengun
Department of Periodontology, Faculty of Dentistry, Hacettepe University, 3rd Floor, Sihhiye, 06100, Ankara, Turkey.
Ezel
E
Berker
D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000097:blood; D015331:Cohort Studies; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D005891:Gingivitis / Q000097:blood; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000097:blood / Q000178:diet therapy / Q000188:drug therapy; D007249:Inflammation / Q000517:prevention & control; D016753:Interleukin-10 / Q000032:analysis*; D053583:Interleukin-1beta / Q000032:analysis* / Q000187:drug effects; D010519:Periodontium / Q000187:drug effects / Q000473:pathology; D009195:Peroxidase / Q000032:analysis* / Q000187:drug effects
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C508609:IL10 protein, human; D053583:Interleukin-1beta; D016753:Interleukin-10; D009195:Peroxidase
IL-10; IL-1β; inflammation; periodontal diseases; statins