Distribution of EGFR Mutations in 10,607 Russian Patients with Lung Cancer.
This study was aimed to evaluate distribution of epidermal growth factor receptor (EGFR) mutations in a large series of Russian lung cancer (LC) patients.



10,607 LC samples were considered for EGFR analysis; EGFR status was successfully determined in 10,426 cases (98.3 %), indicating relatively low failure rate.



EGFR mutations (ex19del and L858R) were detected in 1759/8716 (20.2 %) adenocarcinomas, 28/669 (4.2 %) squamous cell carcinomas (SCC) and 8/119 (6.7 %) large cell carcinomas. The occurrence of EGFR mutations in adenocarcinomas gradually increased with age, being attributed mainly to the increment of the L858R frequency in non-smokers (patients aged 18-30 years: 1/27 (3.7 %); 31-40 years: 5/98 (5.1 %); 41-50 years: 18/276 (6.5 %); 51-60 years: 102/944 (10.8 %); 61-70 years: 138/1011 (13.7 %); 71-80 years: 85/496 (17.1 %); 81-100 years: 5/27 (18.5 %); p < 0.0001). The EGFR mutation was detected in 804/2107 (38.2 %) non-smoking women versus 125/806 (15.5 %) non-smoking men (p < 0.0001), while the corresponding figures for smokers were 60/273 (22.0 %) versus 147/2214 (6.6 %) (p < 0.0001). The obtained gender-related data differ from the estimates obtained in Asian studies; they indicate that increased prevalence of EGFR mutations in white females may not be entirely attributed to the low prevalence of smoking, but is likely to be related to gender factors per se.



Biological causes of distinct age- and gender-related distribution of EGFR mutations in LC deserve further investigation.
N.N. Petrov Institute of Oncology, St.-Petersburg, 197758, Russia. evgeny@imyanitov.spb.ru.|St.-Petersburg Pediatric Medical University, St.-Petersburg, 194100, Russia. evgeny@imyanitov.spb.ru.|I.I. Mechnikov North-Western Medical University, St.-Petersburg, 191015, Russia. evgeny@imyanitov.spb.ru.|St.-Petersburg State University, St.-Petersburg, 199034, Russia. evgeny@imyanitov.spb.ru.
Evgeny N
EN
Imyanitov
City Oncological Hospital No 62, Moscow, 143423, Russia.
Irina A
IA
Demidova
Tatarstan Cancer Center, Kazan, 420029, Russia.
Marat G
MG
Gordiev
Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, 630090, Russia.
Maxim L
ML
Filipenko
Research Center of Medical Genetics, Moscow, 115478, Russia.
Tatyana V
TV
Kekeyeva
Regional Oncological Hospital, Krasnodar, 350051, Russia.
Yuri K
YK
Moliaka
Tomsk Cancer Research Institute, Tomsk, 634028, Russia.
Polina A
PA
Gervas
Pacific Institute of Bioorganic Chemistry, Vladivostok, 690022, Russia.
Valeriy B
VB
Kozhemyako
Institute of Oncology, Rostov, 344037, Russia.
Dmitriy I
DI
Vodolazhskiy
Regional Oncological Hospital, Ekaterinburg, 620000, Russia.
Liubov A
LA
Sergeyeva
Oncological Hospital of the Republic of Bashkortostan, Ufa, 450054, Russia.
Dinara U
DU
Fattakhova
N.N. Petrov Institute of Oncology, St.-Petersburg, 197758, Russia.|St.-Petersburg Pediatric Medical University, St.-Petersburg, 194100, Russia.
Aglaya G
AG
Iyevleva
N.N. Petrov Institute of Oncology, St.-Petersburg, 197758, Russia.
Natalia V
NV
Mitiushkina
N.N. Petrov Institute of Oncology, St.-Petersburg, 197758, Russia.
Ekatherina Sh
ESh
Kuligina
City Oncological Hospital No 62, Moscow, 143423, Russia.
Alexey A
AA
Barinov
Tatarstan Cancer Center, Kazan, 420029, Russia.
Meriiam S
MS
Mommaeva
N.N. Petrov Institute of Oncology, St.-Petersburg, 197758, Russia.|St.-Petersburg State University, St.-Petersburg, 199034, Russia.
Svetlana N
SN
Aleksakhina
Russian Society of Clinical Oncology (RUSSCO), Moscow, 127051, Russia.
Ilya V
IV
Tsimafeyeu
N.N. Blokhin Cancer Center, Moscow, 115478, Russia.
Sergey A
SA
Tjulandin
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011159:Population Surveillance; D015995:Prevalence; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D055815:Young Adult
C512478:EGFR protein, human; D066246:ErbB Receptors