Recent developments in cyclodextrin functionalized monolithic columns for the enantioseparation of chiral drugs.
The use of monolithic supports containing cyclodextrins (CDs) or their derivatives as chiral stationary phases (CSPs) has drawn much attention in the field of enantioseparations. The present review summarized the recent developments in CD functionalized monolithic columns. After introducing their classification in Section 1, various strategies applied to the preparation of the three types of CD functionalized monoliths, i.e. silica based monoliths, organic polymer based monoliths and organic-silica based hybrid monoliths, are thoroughly summarized in Section 2. Particularly, three different preparation strategies for covalently immobilizing CDs onto monoliths, including multi-step strategy, single-step strategy and one-pot strategy, are discussed. In the last section, the applications of CD functionalized monoliths in chiral separation of pharmaceuticals are highlighted.
Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Jinan University, Guangzhou 510632, China.
Jialiang
J
Guo
Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Jinan University, Guangzhou 510632, China.
Yuanjing
Y
Lin
Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Jinan University, Guangzhou 510632, China.
Yuan
Y
Xiao
Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Jinan University, Guangzhou 510632, China; Laboratory of Analytical Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, University of Liege, CHU B36, B-4000 Liege, Belgium.
Jacques
J
Crommen
Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Jinan University, Guangzhou 510632, China. Electronic address: jzjjackson@hotmail.com.
Zhengjin
Z
Jiang
D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods; D003505:Cyclodextrins / Q000032:analysis* / Q000737:chemistry*; D046209:Electrophoresis, Microchip / Q000295:instrumentation / Q000379:methods; D058105:Polymerization; D012822:Silicon Dioxide / Q000737:chemistry; D013237:Stereoisomerism
D003505:Cyclodextrins; D012822:Silicon Dioxide
Cyclodextrin; Enantioseparation; Monolithic column; Preparation strategy