Radiotherapeutic bandage for the treatment of squamous cell carcinoma of the skin.
Squamous cell carcinoma (SCC) is the second most common form of skin cancer in the United States. The efficacy of a pharmaceutically elegant radiotherapeutic bandage, previously described by us for application against SCC of the skin, was tested for the first time in vivo using a subcutaneous SCC mouse model and a therapeutically relevant radiation dose.



Female athymic nude mice were injected with human Colo-16 SCC cells subcutaneously and after eight days (average tumor volume: 35±8.6mm(3)) received no treatment, or were exposed to non-radioactive or radioactive (92.5±18.5MBq) bandages for approximately 1h (n=10 per group). After treatment, tumors were measured over fifteen days, tumor volume ratios (TVRs) compared and histopathology performed.



Fifteen days after treatment, the TVR of the radioactive bandage treatment group was 3.3±4.5, while TVRs of the non-radioactive bandage treatment and no treatment control groups were 33.2±14.7 and 26.9±12.6, respectively. At the time of necropsy, there was mild focal epidermal hyperplasia surrounding a small area of epidermal ulceration in the radioactive bandage group. No other examined tissue (i.e., muscle, liver, kidney, lung, spleen and heart) showed significant lesions.



Our radiotherapeutic bandage exhibits promising efficacy against SCC of the skin in a mouse model. It can be individually tailored for easy application on tumor lesions of all shapes and sizes, and could complement or possibly replace surgery in the clinic.
Department of Pharmaceutical Sciences, University of North Texas (UNT) System College of Pharmacy, UNT Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX, 76107.
Bhuvaneswari
B
Koneru
Department of Pharmaceutical Sciences, University of North Texas (UNT) System College of Pharmacy, UNT Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX, 76107.
Yi
Y
Shi
Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX, 75080.
Imalka
I
Munaweera
Animal Resource Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390.
Mary
M
Wight-Carter
Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, 2130 W. Holcombe Blvd., Houston, TX, 77030.
Humam
H
Kadara
Department of Radiology, University of North Carolina (UNC) School of Medicine, UNC Chapel Hill, 125 Mason Farm Rd., Chapel Hill, NC, 27599.
Hong
H
Yuan
Department of Pharmaceutical Sciences, University of North Texas (UNT) System College of Pharmacy, UNT Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX, 76107. Electronic address: Anthony.dipasqua@unthsc.edu.
Anthony J
AJ
Di Pasqua
Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX, 75080. Electronic address: Balkus@utdallas.edu.
Kenneth J
KJ
Balkus
D000818:Animals; D001458:Bandages; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D051379:Mice; D012306:Risk; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy*
Bandages; Carcinoma; Nanostructures; Radiotherapy; Skin neoplasms; Squamous cell