Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro.
The present study aimed to reveal the expression of STAT3 and Anxa 2 in CRC specimens and to investigate the effects of STAT3 and Anxa 2 signaling on the proliferation, invasion, and migration in CRC Caco-2 cells. Results demonstrated that both Anxa 2 and STAT3 were highly expressed in CRC specimens in both mRNA and protein levels, with or without phosphorylation (Tyrosine 23 in Anxa 2 and Tyrosine 705 in STAT3). And the upregulated Anxa 2 promoted the phosphorylation of STAT3 (Tyrosine 705) in CRC Caco-2 cells. The upregulated Anxa 2 promoted the proliferation, migration, and invasion of Caco-2 cells in vitro. Moreover, the STAT3 knockdown also repressed the proliferation, migration, and invasion of Caco-2 cells. In conclusion, the overexpressed Annexin A2 regulated the proliferation, invasion, and migration in CRC cells in an association with STAT3.
Department of Radiology, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Dianhui
D
Xiu
Department of Radiology, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Lin
L
Liu
Department of Ultrasonography, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Fengli
F
Qiao
Department of Radiology, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Haishan
H
Yang
China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Lu
L
Cui
Department of Radiology, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Guifeng
G
Liu