[Analysis of curative effect of surgical therapy for male prolactinoma].
OBJECTIVE
To summarize the treatment outcome of surgery for male prolactinoma.


METHODS
One hundred and eighty-four cases of male prolactinoma who underwent surgery were analyzed retrospectively.The average age of patients was 36.3 years, and the mean course was 41.9 months.The main clinical manifestation included sexual dysfunction (47.4%), headache (55.9%) and visual disturbance (46.7%). The serum prolactin levels ranged from 6.83 to 9 325.32 nmol/L.The size of tumors varied from 6 mm to 70 mm.Suprasellar adenoma with visual deficits accounted for 40.7%. 98.9% patients underwent pituitary adenoma resection via single nasal transsphenoidal approach.


RESULTS
Postoperative pathological Ki-67 index of most patients (45.1%) were less than 1%.After surgical therapy, 163 patients (88.6%) got relief of symptoms, 57 patients (31.0%) achieved initial remission, and 26 patients (45.6%) unfortunately recurred. The possibility of gross resection decreased as tumor size increased (P<0.05). Preoperative PRL had no significant relation with both tumor size and extent of resection (P>0.05). The favorable prognosis predictive factors included microadenoma, intrasellar adenoma and Ki-67 index≤3 (P<0.01).


CONCLUSIONS
Male prolactinomas is an invasive tumor with higher serum prolactin level.Tumor size could predict degree of gross resection while predictors for recurrence include tumor size, growth pattern and Ki-67 index.
Department of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China.
M T
MT
Chen
Y J
YJ
Song
W
W
Lian
B
B
Xing
Y
Y
Yao
M
M
Feng
R Z
RZ
Wang
D000236:Adenoma / Q000097:blood / Q000601:surgery*; D000328:Adult; D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010911:Pituitary Neoplasms / Q000097:blood / Q000601:surgery*; D011184:Postoperative Period; D011388:Prolactin / Q000097:blood; D015175:Prolactinoma / Q000097:blood / Q000601:surgery*; D012189:Retrospective Studies; D012735:Sexual Dysfunction, Physiological / Q000209:etiology; D016896:Treatment Outcome
D011388:Prolactin