Are patients with lichen planus really prone to urolithiasis? Lichen planus and urolithiasis.
OBJECTIVE
to investigate whether patients with lichen planus (LP) are really prone to urolithiasis or not.


METHODS
We performed a prospective analysis of 40 patients diagnosed with lichen planus (LP) (group I), and 40 volunteers did not have LP before (group II). Participants were all checked for urolithiasis by radiological investigations. Blood samples were analyzed for biochemistry parameters including calcium and uric acid. 24-h urine samples were analyzed to investigate oxalate, citrate calcium, uric acid, magnesium, sodium and creatinine.


RESULTS
Men/women ratio and mean age were similar between group I and II (p>0.05). A presence or history of urolithiasis was detected in 8 (20%) and 2 (%5) patients in group I and II, respectively (p<0.05). Hypocitraturia was the most common anomaly with 35% (n:14) in group I. The rate of hypocitraturia in group II was 12.5% (n:5) and the difference was statistically significantly different (p=0.036). In group I, hyperuricosuria and hyperoxaluria followed with rates of 27.5% (n:11) and 25% (n:10), respectively. The rate of hyperuricosuria and hyperoxaluria were both 5% (n:2) in group II and the differences were significant (p<0.05). Hyperuricemia was another importante finding in the patients with LP. It was detected in 13 (32.5%) patients in group I and in 1 (2.5%) participant in group II (p=0.001).


CONCLUSIONS
According to our results, metabolic disorders of urolithiasis were highly detected in the patients with LP. However, similar to the etiology of LP, the exact reasons for these metabolic abnormalities in LP remain a mystery.
Department of Urology, School of Medicine, University Giresun, Giresun, Turkey.
Ural
U
Oguz
Department of Dermatology, School of Medicine, University Gaziosmanpasa, Tokat, Turkey.
Zennure
Z
Takci
Department of Dermatology, Prof. Dr. A. Ilhan Ozdemir State Hospital, Giresun, Turkey.
Isil Deniz
ID
Oguz
Department of Urology, School of Medicine, University Onsekiz Mart, Canakkale, Turkey.
Berkan
B
Resorlu
Department of Dermatology, Kecioren Training and Research Hospital, Ankara, Turkey.
Ilknur
I
Balta
Department of Urology, School of Medicine, University Gazi, Ankara, Turkey.
Ali
A
Unsal
D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood; D019355:Calcium Citrate / Q000652:urine; D016022:Case-Control Studies; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000150:complications* / Q000652:urine; D008274:Magnesium / Q000652:urine; D008297:Male; D008659:Metabolic Diseases / Q000150:complications / Q000652:urine; D008875:Middle Aged; D010070:Oxalates / Q000652:urine; D011446:Prospective Studies; D012016:Reference Values; D012307:Risk Factors; D012964:Sodium / Q000652:urine; D014527:Uric Acid / Q000097:blood / Q000652:urine; D016482:Urinalysis; D052878:Urolithiasis / Q000209:etiology* / Q000652:urine; D055815:Young Adult
D010070:Oxalates; D014527:Uric Acid; D012964:Sodium; D003404:Creatinine; D008274:Magnesium; D019355:Calcium Citrate; D002118:Calcium