Films based on neutralized chitosan citrate as innovative composition for cosmetic application.
In this work, citrate and acetate buffers, were investigated as neutralizers to chitosan salts in order to provide biocompatible and stable films. To choose the appropriate film composition for this study, neutralized chitosan citrate and acetate films, with and without the plasticizer glycerol, were prepared and characterized by thickness, moisture content, degree of swelling, total soluble matter in acid medium, simultaneous thermal analysis and differential scanning calorimetry. Chitosan films neutralized in citrate buffer showed greater physical integrity resulted from greater thicknesses, lower moisture absorbance, lower tendency to solubility in the acid medium, and better swelling capacities. According to thermal analyses, these films had higher interaction with water which is considered an important feature for cosmetic application. Since the composition prepared in citrate buffer without glycerol was considered to present better physical integrity, it was applied to investigate hyaluronic acid release in a skin model. Skins treated with those films, with or without hyaluronic acid, show stratum corneum desquamation and hydration within 10min. The results suggest that the neutralized chitosan citrate film prepared without glycerol promotes a cosmetic effect for skin exfoliation in the presence or absence of hyaluronic acid.
Chemistry Institute, Universidade Federal do Rio Grande do Sul, Bento Gonçalves 9500, Porto Alegre, Brazil.
Illen C
IC
Libio
Chemistry Institute, Universidade Federal do Rio Grande do Sul, Bento Gonçalves 9500, Porto Alegre, Brazil.
Renan
R
Demori
Chemistry Institute, Universidade Federal do Rio Grande do Sul, Bento Gonçalves 9500, Porto Alegre, Brazil.
Marco F
MF
Ferrão
Department of Pharmacological Sciences, Universidade Federal de Ciências da Saúde de Porto Alegre, Sarmento Leite 245, Porto Alegre, Brazil.
Maria I Z
MIZ
Lionzo
Chemistry Institute, Universidade Federal do Rio Grande do Sul, Bento Gonçalves 9500, Porto Alegre, Brazil. Electronic address: nadya@iq.ufrgs.br.
Nádya P
NP
da Silveira
D000818:Animals; D048271:Chitosan / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003358:Cosmetics / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D008567:Membranes, Artificial; D012867:Skin / Q000378:metabolism*; D013552:Swine
D003358:Cosmetics; D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; C408130:chitosan citrate; D006820:Hyaluronic Acid; D048271:Chitosan
Characterization; Chitosan film; Citrate buffer; Cosmetic application; Exfoliation