Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection.
The subunit makeup of the family of adenosine triphosphate-sensitive potassium channel (KATP) channels is more complex and labile than thought. The growing association of Kir6.1 and SUR2 variants with specific cardiovascular electrical and contractile derangements and the clear association with Cantu syndrome establish the importance of appropriate activity in normal function of the heart and vasculature. Further studies of such patients will reveal new mutations in KATP subunits and perhaps in proteins that regulate KATP synthesis, trafficking, or location, all of which may ultimately benefit therapeutically from the unique pharmacology of KATP channels.
Department of Cell Biology and Physiology, Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA. Electronic address: cnichols@wustl.edu.
Colin G
CG
Nichols
D000818:Animals; D006332:Cardiomegaly / Q000235:genetics / Q000503:physiopathology; D006331:Heart Diseases / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D006983:Hypertrichosis / Q000235:genetics / Q000503:physiopathology; D054086:KATP Channels / Q000235:genetics / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D010009:Osteochondrodysplasias / Q000235:genetics / Q000503:physiopathology; D026902:Potassium Channel Blockers
D054086:KATP Channels; D026902:Potassium Channel Blockers
Arrhythmia; Cantu; Edema; Kir6.1; Kir6.2; SUR2; Vasodilation