Effect of Cytotoxic Compounds on Activity of Antioxidant Enzyme System in MCF-7 and H1299 Cells.
We studied the function of the antioxidant system in tumor cell lines MCF-7 and H1299 that differ by the state of tumor suppressor gene p53. Exposure to different classes of cytotoxic compounds induced several types of antioxidant system responses that depend on the type of cell line. The effects of platinum(II) and platinum(IV) complexes on activity of antioxidant enzymes vary, which can be explained by differences in their accumulation and biotransformation in tumor cells. Triazole and oxazolidinone derivatives had little effect on activity of superoxide dismutase and catalase in H1299 cells, but increased superoxide dismutase activity in MCF-7 cells.
Institute of Problems Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russia. vmumyatova@bk.ru.
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Mumyatova
Institute of Problems Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russia.
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Balakina
Institute of Problems Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russia.
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Filatova
Institute of Problems Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russia.
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Sen'
Institute of Problems Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russia.
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Korepin
Institute of Problems Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russia.
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Terentev
D000970:Antineoplastic Agents / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism*; D002945:Cisplatin / Q000633:toxicity*; D004790:Enzyme Induction; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D009944:Organoplatinum Compounds / Q000633:toxicity*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism*
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D017382:Reactive Oxygen Species; C081294:satraplatin; D002374:Catalase; D013482:Superoxide Dismutase; D002945:Cisplatin
antioxidant system; catalase; platinum(IV) amino nitroxyl complexes; reactive oxygen species; superoxide dismutase