Role of flow cytometry in multiple myeloma and the prognostic significance of CD87 (uPAR) expression.
OBJECTIVE
The plasminogen activator system consists of the serine protease urokinase plasminogen activator (uPA), two endogenous inhibitors of PAI-1 (plasminogen activator inhibitor-1) as well as the PAI-2 and uPA receptor (uPAR or CD87). The aim of this study was to determine the significance of flow cytometry and CD87, CD45 and CD56 expressions in the diagnosis, follow-up and prognosis of multiple myeloma (MM).


METHODS
Twenty-nine MM patients were included in the study. Bone marrow samples were used for flow cytometry. A panel of CD87, CD45, CD56, CD10, CD19, CD20, CD38, and CD138 was tested by flow cytometry.


RESULTS
CD87 was negative in 8 (27.5%) cases, dim positive in 9 (31.1%) and bright positive in 12 (41.4%). CD87 expression was significantly higher in CD45 (-) cases.


CONCLUSIONS
Flow cytometry has a significant role in the diagnosis and prognosis of MM. Further clinical studies including large numbers of patients are needed to determine the prognostic role of CD87 in MM.
Murat
M
Albayrak
Dizgi Sok. 9/6 Basınevleri, 06120 Ankara, Turkey Phone: +90 312 321 66 97 E-mail: drozlembalcik@yahoo.com.
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