Innate immune memory in mammals.
Innate and adaptive immunity have evolved as sophisticated mechanisms of host defence against invading pathogens. Classically the properties attributed to innate immunity are its rapid pleiotropic response, and to adaptive immunity its specificity and ability to retain a long-term memory of past infections. It is now clear that innate immunity also contributes to raising a memory response upon pathogenic assault. In this review we will discuss the interaction between bacterial, viral, fungal and parasitic molecular patterns and innate immune cells in which a memory response is imposed, or has the potential to be imposed.
Chromatin and Infection group, Department of Cell Biology & Infection, Institut Pasteur, 25 rue du Docteur Roux, Paris, France.
Melanie A
MA
Hamon
Immunology of fungal infections group, Department of Mycology, Institut Pasteur, 25 rue du Docteur Roux, Paris, France. Electronic address: jessica.quintin@pasteur.fr.
Jessica
J
Quintin
D056704:Adaptive Immunity; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory; D007239:Infections / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology* / Q000821:virology; D008264:Macrophages / Q000276:immunology* / Q000821:virology; D008322:Mammals / Q000276:immunology*; D009000:Monocytes / Q000276:immunology* / Q000821:virology; D000069452:Pathogen-Associated Molecular Pattern Molecules / Q000276:immunology
D000956:Antigens, Viral; D000069452:Pathogen-Associated Molecular Pattern Molecules
Infection; Innate immune memory; Macrophages; Monocytes; NK cells; Pathogens