Inter-hemispheric plasticity in patients with median nerve injury.
Peripheral nerve injuries result in reorganization within the contralateral hemisphere. Furthermore, recent animal and human studies have suggested that the plastic changes in response to peripheral nerve injury also include several areas of the ipsilateral hemisphere. The objective of this study was to map the inter-hemispheric plasticity in response to median nerve injury, to investigate normal differences in contra- and ipsilateral activation, and to study the impact of event-related or blocked functional magnetic resonance imaging (fMRI) design on ipsilateral activation. Four patients with median nerve injury at the wrist (injured and epineurally sutured >2 years earlier) and ten healthy volunteers were included. 3T fMRI was used to map the hemodynamic response to brain activity during tactile stimulation of the fingers, and a laterality index (LI) was calculated. Stimulation of Digits II-III of the injured hand resulted in a reduction in contralateral activation in the somatosensory area SI. Patients had a lower LI (0.21±0.15) compared to healthy controls (0.60±0.26) indicating greater ipsilateral activation of the primary somatosensory cortex. The spatial dispersion of the coordinates for areas SI and SII was larger in the ipsilateral than in the contralateral hemisphere in the healthy controls, and was increased in the contralateral hemisphere of the patients compared to the healthy controls. There was no difference in LI between the event-related and blocked paradigms. In conclusion, patients with median nerve injury have increased ipsilateral SI area activation, and spatially more dispersed contralateral SI activation during tactile stimulation of their injured hand. In normal subjects ipsilateral activation has larger spatial distribution than the contralateral. Previous findings in patients performed with the blocked fMRI paradigm were confirmed. The increase in ipsilateral SI activation may be due to an interhemispheric disinhibition associated with changes in the afferent signal inflow to the contralateral primary somatosensory cortex.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Orthopaedics, Vrinnevi Hospital, Norrköping, Sweden. Electronic address: Lotta.B.Fornander@regionostergotland.se.
Lotta
L
Fornander
Pain and Rehabilitation Centre, UHL, County Council of Östergötland, Linköping, Sweden.
Torbjörn
T
Nyman
Division of Plastic Surgery, Hand Surgery and Burns, Department of Clinical and Experimental Medicine, Linköping University, Sweden.
Thomas
T
Hansson
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Tom
T
Brismar
Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Maria
M
Engström
D000328:Adult; D000368:Aged; D001931:Brain Mapping; D005385:Fingers / Q000503:physiopathology; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008475:Median Nerve / Q000293:injuries* / Q000503:physiopathology*; D008875:Middle Aged; D009473:Neuronal Plasticity; D010812:Physical Stimulation; D013003:Somatosensory Cortex / Q000503:physiopathology*; D014110:Touch / Q000502:physiology*; D055698:Touch Perception / Q000502:physiology*; D055815:Young Adult
Cortical plasticity; Human; Median nerve; Peripheral nerve injury; Regeneration; fMRI