Motor features in Parkinson's disease with normal olfactory function.
Normosmic Parkinson's disease (PD) might be a unique clinical phenotype with a more benign course when compared with hyposmic PD.



The objective of this study was to evaluate motor features and the acute levodopa response according to olfactory function.



A total of 169 de novo PD patients that underwent olfactory testing and acute levodopa challenge for clinical prediction of sustained long-term dopaminergic response were evaluated.



The overall frequency of normosmia was 33%. Normosmic PD patients scored nonsignificantly different to hyposmic/anosmic patients on motor scale and on degree of improvement with levodopa. Motor scores at follow-up were comparable among groups.



Normal olfactory function is common in early PD and was not associated with a different motor phenotype when compared with PD patients with olfactory dysfunction. © 2016 International Parkinson and Movement Disorder Society.
Movement Disorders Section, Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Ciudad Autónoma de Buenos Aires, Argentina.
Malco
M
Rossi
Movement Disorders Section, Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Ciudad Autónoma de Buenos Aires, Argentina.
Alex Medina
AM
Escobar
Movement Disorders Section, Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Ciudad Autónoma de Buenos Aires, Argentina.
Andrea
A
Bril
Movement Disorders Section, Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Ciudad Autónoma de Buenos Aires, Argentina.
Patricio
P
Millar Vernetti
Movement Disorders Section, Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Ciudad Autónoma de Buenos Aires, Argentina.
Juan Ignacio
JI
De Palo
Movement Disorders Section, Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Ciudad Autónoma de Buenos Aires, Argentina.
Daniel
D
Cerquetti
Movement Disorders Section, Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Ciudad Autónoma de Buenos Aires, Argentina. mmerello@fleni.org.ar.|Argentine National Scientific and Technological Research Council (CONICET), Buenos Aires, Argentina. mmerello@fleni.org.ar.
Marcelo
M
Merello
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055696:Olfactory Perception / Q000502:physiology*; D010300:Parkinson Disease / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D010468:Perceptual Disorders / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*
Parkinson's disease; levodopa response; motor features; normosmia; olfaction