Cytokines, adipocytokines and inflammatory markers in patients on continuous ambulatory peritoneal dialysis and hemodialysis.
BACKGROUND
Cytokines are essential mediators of immune response. Chronic renal failure patients suffer from chronic inflammation that results from factors such as impaired renal function, accumulation of uremic toxins and bio incompatibility of dialyzer membranes. These patients are also at increased risk of cardiovascular diseases. We have evaluated cytokines, adipocytokines and inflammatory markers in patients with chronic renal failure undergoing hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD).


METHODS
We have determined serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP), leptin and ghrelin levels of chronic renal failure patients treated with either HD (n = 20) or CAPD (n = 20). TNF-α, IL-6, ghrelin and leptin measurements were performed by commercially available kits based on enzyme-linked immunosorbent assay (ELISA) method. hsCRP levels were determined by turbidimetric methods.


RESULTS
Serum TNF-α and IL-6 levels of patients on HD were significantly higher than those of the ones on CAPD (p < 0.05). Ghrelin, leptin and hsCRP concentrations were similar in both groups.


CONCLUSIONS
We can conclude that cytokine production is more obvious in HD process.
a Department of Biochemistry , Mevlana University Medical Faculty , Konya , Turkey ;
Mufide
M
Oncel
b Department of Biochemistry , Nevsehir State Hospital , Nevsehir , Turkey ;
Seval
S
Akbulut
c Department of Microbiology , Mevlana University Medical Faculty , Konya , Turkey ;
Turkan
T
Toka Ozer
a Department of Biochemistry , Mevlana University Medical Faculty , Konya , Turkey ;
Aysel
A
Kiyici
d Department of Internal Medicine , Mevlana University Medical Faculty , Konya , Turkey ;
Mustafa
M
Keles
d Department of Internal Medicine , Mevlana University Medical Faculty , Konya , Turkey ;
Beyhan
B
Baltaci
e Department of Internal Medicine , Selcuk University Medical Faculty , Konya , Turkey.
Suleyman
S
Turk
D054392:Adipokines / Q000097:blood*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D054439:Ghrelin / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D006435:Renal Dialysis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D054392:Adipokines; D015415:Biomarkers; D016207:Cytokines; C515349:GHRL protein, human; D054439:Ghrelin; C508600:IL6 protein, human; D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein
Adipocytokines; continuous ambulatory peritoneal dialysis; cytokines; hemodialysis; hsCRP