Brief Report: Plasma Concentrations of Perfluorooctane Sulfonamide and Time-to-pregnancy Among Primiparous Women.
A previous study reported a negative association between perfluorooctane sulfonamide (PFOSA) concentrations and fecundability.



We examined this association among women enrolled in the Norwegian Mother and Child Cohort Study (MoBa), in 2003-2004. This analysis was restricted to 451 primiparous women to avoid bias due to previous pregnancy. Self-reported time-to-pregnancy (TTP) and plasma were obtained around 18 weeks of gestation. Approximately half of the women had measurable PFOSA levels; missing values were multiply imputed. We used the logistic analogue of discrete-time survival analysis to examine the adjusted association between PFOSA, other perfluoroalkyl substances, and TTP.



The median-measured PFOSA concentration was 0.03 ng/ml (interquartile range = 0.02, 0.07). The age and body mass index-adjusted association between an interquartile distance increase in PFOSA and TTP was 0.91 (95% confidence interval = 0.71, 1.17). Imputation of missing PFOSA resulted in similar estimates. No association was observed with other perfluoroalkyl substances.



Based on a weakly decreased fecundability odds ratio, we found only limited support for an association between plasma PFOSA concentrations and TTP among primiparous women. See Video Abstract at http://links.lww.com/EDE/B79.
From the aDepartment of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas School of Public Health at Houston, San Antonio Regional Campus, San Antonio, TX; bSouthwest Center for Occupational and Environmental Health, The University of Texas School of Public Health at Houston, Houston, TX; cNorwegian Institute of Public Health, Oslo, Norway; dDepartment of Health and Human Services, National Institute for Environmental Health Sciences, National Institutes of Health, Durham NC.
Kristina W
KW
Whitworth
Line S
LS
Haug
Azemira
A
Sabaredzovic
Merete
M
Eggesbo
Matthew P
MP
Longnecker
D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D002853:Chromatography, Liquid; D015331:Cohort Studies; D004781:Environmental Exposure; D005260:Female; D005466:Fluorocarbons / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D013058:Mass Spectrometry; D008423:Maternal Age; D009664:Norway; D016017:Odds Ratio; D010298:Parity; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D057566:Self Report; D013449:Sulfonamides / Q000097:blood*; D061685:Time-to-Pregnancy; D055815:Young Adult
D005466:Fluorocarbons; D013449:Sulfonamides; C063900:perfluorooctanesulfonamide