Water soluble nanocurcumin extracted from turmeric challenging the microflora from human oral cavity.
Water soluble nanocurcumin prepared from commercial turmeric powders was compared against ethanol extracted curcumin particles. The oral microflora from five different human volunteers was collected and the efficacy of solvent extracted curcumin versus water extracted nanocurcumin was demonstrated. Nanocurcumin activity against oral microflora confirms its antimicrobial potency. Confocal laser scanning microscopic results revealed the enhanced entry of nanocurcumin particles into microbial cells. The nanosized nature of nanocurcumin appears to have led to increased cellular interaction and thereby efficient destruction of microbial cells in the mouth. In addition, solubility of nanocurcumin is also believed to be a crucial factor behind its successful antimicrobial activity. This study proves that the bioactivity of a compound is greatly influenced by its solubility in water. This work recommends the use of water soluble nanocurcumin (extracted from turmeric) as potent substitute for curcumin in dental formulations.
Department of Molecular Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea.
Judy
J
Gopal
Department of Molecular Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea.
Manikandan
M
Muthu
Department of Molecular Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea. Electronic address: scchun@konkuk.ac.kr.
Se-Chul
SC
Chun
D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry*; D006801:Humans; D009055:Mouth / Q000382:microbiology*; D053758:Nanoparticles / Q000737:chemistry*; D014838:Volunteers; D014867:Water
D014867:Water; D003474:Curcumin
Human volunteers; Inhibition; Nanocurcumin; Oral bacteria; Turmeric