Bioactive Secondary Metabolites from Schizogyne sericea (Asteraceae) Endemic to Canary Islands.
Schizogyne sericea (Asteraceae) is a halophytic shrub endemic to the Canary Islands and traditionally employed as analgesic, astringent, anti-inflammatory, and vulnerary. A comprehensive phytochemical investigation was conducted on the flowering aerial parts by analyzing both essential oil constituents and polar compounds. The essential oil was dominated by p-cymene, with the noteworthy occurrence of β-pinene and thymol esters. From the EtOH extract, eight compounds were isolated and structurally elucidated. Essential oil, polar fractions, and isolates (2), (4), and (5) were separately in vitro assayed for antiproliferative activity on human tumor cell lines (A375, MDA-MB 231, and HCT116) by MTT assay, for antioxidant potential by DPPH, ABTS, and FRAP assays, and for antimicrobial activity by the agar disk diffusion method. Results revealed that essential oil and compounds 1 and 2 exert a strong inhibition on tumor cells, and in some cases, higher than that of cisplatin. Fractions containing thymol derivatives (1 and 2) and caffeoylquinic acid derivatives 4 and 5 displayed antioxidant activity comparable to that of Trolox, making S. sericea extract an interesting natural product with potential applications as preservative or in the treatment of diseases in which oxidative stress plays an important role.
Department of Chemistry, Sapienza University, Piazzale Aldo Moro 5, IT-00185, Rome. alessandro.venditti@uniroma1.it.|Department of Environmental Biology, Sapienza University, Piazzale Aldo Moro 5, IT-00185, Rome. alessandro.venditti@uniroma1.it.
Alessandro
A
Venditti
Department of Chemistry, Sapienza University, Piazzale Aldo Moro 5, IT-00185, Rome.
Armandodoriano
A
Bianco
Department of Chemistry, Sapienza University, Piazzale Aldo Moro 5, IT-00185, Rome.
Camilla
C
Muscolo
Departamento de Medicina Física y Farmacología, Facultad de Farmacia, Universidad de La Laguna, Campus de Ofra, ES-38071, San Cristóbal de La Laguna, Tenerife.
Christian
C
Zorzetto
Departamento de Medicina Física y Farmacología, Facultad de Farmacia, Universidad de La Laguna, Campus de Ofra, ES-38071, San Cristóbal de La Laguna, Tenerife.
Candelaria C
CC
Sánchez-Mateo
Departamento de Medicina Física y Farmacología, Facultad de Farmacia, Universidad de La Laguna, Campus de Ofra, ES-38071, San Cristóbal de La Laguna, Tenerife.
Rosa M
RM
Rabanal
School of Pharmacy, University of Camerino, Via Sant'Agostino 1, IT-62032, Camerino.
Luana
L
Quassinti
School of Pharmacy, University of Camerino, Via Sant'Agostino 1, IT-62032, Camerino.
Massimo
M
Bramucci
School of Pharmacy, University of Camerino, Via Sant'Agostino 1, IT-62032, Camerino.
Silvia
S
Damiano
School of Pharmacy, University of Camerino, Via Sant'Agostino 1, IT-62032, Camerino.
Romilde
R
Iannarelli
School of Pharmacy, University of Camerino, Via Sant'Agostino 1, IT-62032, Camerino.
Giulio
G
Lupidi
School of Science and Technology, University of Camerino, Via Sant'Agostino 1, IT-62032, Camerino.
Fabrizio
F
Papa
School of Bioscience and Veterinary Medicine, University of Camerino, Via Gentile II Da Varano, IT-62032, Camerino.
Dezemona
D
Petrelli
School of Pharmacy, University of Camerino, Via Sant'Agostino 1, IT-62032, Camerino.
Luca A
LA
Vitali
School of Pharmacy, University of Camerino, Via Sant'Agostino 1, IT-62032, Camerino.
Sauro
S
Vittori
School of Pharmacy, University of Camerino, Via Sant'Agostino 1, IT-62032, Camerino.
Filippo
F
Maggi
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology*; D000935:Antifungal Agents / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology*; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry* / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009822:Oils, Volatile / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology*; D010636:Phenols / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology*; D064210:Secondary Metabolism; D013030:Spain; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D009822:Oils, Volatile; D010636:Phenols
Asteraceae; Biological activities; Essential oil; Schizogyne sericea