Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine.
Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA quality control and regulatory process that plays direct roles in human health and disease. In this Minireview, we discuss how understanding the molecular events that trigger NMD can facilitate strategic targeting of genes via CRISPR/Cas9 technologies and also inform disease diagnostics and treatments.
Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA; Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA.
Maximilian W
MW
Popp
Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA; Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA. Electronic address: lynne_maquat@urmc.rochester.edu.
Lynne E
LE
Maquat
D064113:CRISPR-Cas Systems; D018390:Gene Targeting; D005818:Genetic Engineering; D016678:Genome; D006801:Humans; D059365:Nonsense Mediated mRNA Decay; D057285:Precision Medicine; D012333:RNA, Messenger
D012333:RNA, Messenger