Lysosomal and vacuolar sorting: not so different after all!
Soluble hydrolases represent the main proteins of lysosomes and vacuoles and are essential to sustain the lytic properties of these organelles typical for the eukaryotic organisms. The sorting of these proteins from ER residents and secreted proteins is controlled by highly specific receptors to avoid mislocalization and subsequent cellular damage. After binding their soluble cargo in the early stage of the secretory pathway, receptors rely on their own sorting signals to reach their target organelles for ligand delivery, and to recycle back for a new round of cargo recognition. Although signals in cargo and receptor molecules have been studied in human, yeast and plant model systems, common denominators and specific examples of diversification have not been systematically explored. This review aims to fill this niche by comparing the structure and the function of lysosomal/vacuolar sorting receptors (VSRs) from these three organisms.
School of Clinical and Applied Sciences, Faculty of Biomedical Sciences, Leeds Beckett University, Leeds LS13HE, U.K. Centre for Plant Sciences, University of Leeds, Leeds LS29JT, U.K. c.de-marcos-lousa@leedsbeckett.ac.uk j.denecke@leeds.ac.uk.
Carine
C
de Marcos Lousa
Centre for Plant Sciences, University of Leeds, Leeds LS29JT, U.K. c.de-marcos-lousa@leedsbeckett.ac.uk j.denecke@leeds.ac.uk.
Jurgen
J
Denecke
D000818:Animals; D005656:Fungal Proteins / Q000378:metabolism / Q000502:physiology; D006801:Humans; D051907:Lysosomal Membrane Proteins / Q000378:metabolism* / Q000502:physiology; D008247:Lysosomes / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism* / Q000502:physiology; D010940:Plant Proteins / Q000378:metabolism / Q000502:physiology; D010944:Plants / Q000378:metabolism; D011487:Protein Conformation; D021381:Protein Transport; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D014617:Vacuoles / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism* / Q000502:physiology
D005656:Fungal Proteins; D051907:Lysosomal Membrane Proteins; D026901:Membrane Transport Proteins; D010940:Plant Proteins; D033921:Vesicular Transport Proteins
endosomal sorting; lysosomes; receptors; trafficking; vacuole