Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors.
As the major bioactive compound of Scutellaria baicalensis that has been approved to be effective as an anti-inflammatory and antiviral inhibitor in cardiovascular diseases, wogonin (WG) showed potent and promising antitumor effects both in vitro and in vivo. It has been proved that WG has the ability to inhibit the growth of tumor cells, induce apoptosis, and suppress angiogenesis. The molecular mechanisms involve reactive oxygen species, Ca(2+), NF-κB, tumor necrosis factor-related apoptosis-inducing ligand, and tumor necrosis factor-alpha. Furthermore, the synergistic effect of WG with 5-fluorouracil, etoposide, and adriamycin to enhance chemotherapy and reverse drug resistance has also been confirmed. In this review, we summarize the advances in recent years on the antitumor effect of WG on multiple tumors; in addition, we also present information regarding the synergistic and chemosensitizing effects of WG with other drugs to illustrate its potential use in the clinic.
Department of Hematology, School of Medicine, Southeast University, Nanjing, People's Republic of China.
Xue
X
Wu
Department of Oncology, The Affiliated Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People's Republic of China.
Haijun
H
Zhang
Department of Hematology, School of Medicine, Southeast University, Nanjing, People's Republic of China.
Jumah Masoud Mohammad
JM
Salmani
Department of Physiology, China Pharmaceutical University, Nanjing, People's Republic of China.
Rong
R
Fu
Department of Hematology, School of Medicine, Southeast University, Nanjing, People's Republic of China.
Baoan
B
Chen
antitumor effect; drug resistance; mechanisms; synergistic effect