Histologic Evidence for Arteriovenous Malformation-Like Vasculature Occurring within an Intracerebral Schwannoma: A Case Report and Review of the Literature.
BACKGROUND
The phenomenon of intracerebral schwannoma is exceedingly rare, and its etiology still a matter of debate. No documented cases of intracerebral schwannoma containing vascular elements consistent with those of an arteriovenous malformation (AVM) have been reported. We describe such a case here.


METHODS
A left temporal intraparenchymal lesion was discovered incidentally in a 34-year-old man after he suffered a mild trauma. The lesion was resected and found on histologic examination to be an intracerebral schwannoma with AVM-like vasculature. The patient made a full recovery after resection.


CONCLUSIONS
To our knowledge, this is the first case of an intracerebral schwannoma with AVM-like characteristics to be reported in the literature. We hypothesize that the co-occurrence of this rare pathologic entity is caused by an interrelated etiologic process, with the tumor microenvironment of the schwannoma inciting the development of the vascular malformation.
School of Medicine, University of California at San Diego, San Diego, California, USA.
Bayard R
BR
Wilson
Department of Neurosurgery, University of California at San Diego, San Diego, California, USA. Electronic address: J1steinberg@ucsd.edu.
Jeffrey A
JA
Steinberg
Department of Pathology, Division of Neuropathology, University of California at San Diego, San Diego, California, USA.
Vivian
V
Snyder
School of Medicine, University of California at San Diego, San Diego, California, USA.
Michael N
MN
Jiang
Department of Neurosurgery, University of California at San Diego, San Diego, California, USA.
Bob S
BS
Carter
D000328:Adult; D001929:Brain Edema / Q000000981:diagnostic imaging / Q000209:etiology; D001932:Brain Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D002533:Cerebral Angiography; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D009442:Neurilemmoma / Q000150:complications* / Q000000981:diagnostic imaging; D009418:S100 Proteins / Q000378:metabolism; D013702:Temporal Lobe / Q000473:pathology / Q000601:surgery; D015898:Tomography Scanners, X-Ray Computed
D009418:S100 Proteins
Arteriovenous malformation; Intracerebral; Intraparenchymal schwannoma; Schwannoma