DePFth Perception in Clathrin-Mediated Endocytosis.
The earliest stages of clathrin-coated structure (CCS) assembly involve the recruitment and stabilization of clathrin-binding adaptor proteins and the clathrin coat. In this issue of Developmental Cell, Ma et al. (2016) now identify transient protein interactions that form the basis of AP-2 adaptor complex stabilization, key to initiating CCS formation.
Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Mudd Hall, Room 48, Baltimore, MD 21218, USA.
Derek C
DC
Prosser
Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Mudd Hall, Room 48, Baltimore, MD 21218, USA. Electronic address: bwendland@jhu.edu.
Beverly
B
Wendland
D033962:Adaptor Protein Complex 2 / Q000737:chemistry* / Q000378:metabolism*; D020816:Amino Acid Motifs; D000818:Animals; D002966:Clathrin / Q000378:metabolism*; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism; D004705:Endocytosis; D006801:Humans; D008954:Models, Biological
D033962:Adaptor Protein Complex 2; D002966:Clathrin