The utility of PET/CT with (68)Ga-DOTATOC in sarcoidosis: comparison with (67)Ga-scintigraphy.
OBJECTIVE
This study was designed to compare the clinical efficacy of (68)Ga-DOTA-Tyr-octreotide (DOTATOC)-positron emission tomography (PET)/computed tomography (CT) with that of conventional (67)Ga-scintigraphy (GS), and to correlate quantitative parameters on DOTATOC-PET/CT with clinical data, in patients with sarcoidosis.


METHODS
Twenty patients who were histologically and/or clinically diagnosed with sarcoidosis and underwent both DOTATOC-PET/CT and GS were analyzed in this study. The numbers of patients with positive findings for each organ were determined. The total numbers of involved nodal areas in the chest, as determined by DOTATOC-PET and gallium single-photon emission tomography (Ga-SPECT), were compared. The correlations between quantitative parameters on PET and clinical laboratory data were evaluated.


RESULTS
DOTATOC-PET/CT was positive in 19 patients, being negative in only one patient with chronic inactive sarcoidosis, whereas GS was positive in 17 patients. DOTATOC-PET/CT visualized more lesions in lymph nodes, uvea, and muscles than did Ga-scintigraphy and identified more involved areas than did GS-SPECT (p < 0.0001). Whole-body active lesion volume showed a significant, but moderate correlation with angiotensin-converting enzyme level (ρ = 0.64, p = 0.0044).


CONCLUSIONS
PET/CT with DOTATOC may be superior to conventional GS in detecting sarcoidosis lesions, especially in lymph nodes, uvea, and muscles. Volumetric parameters in DOTATOC-PET/CT may be helpful in estimating the activity of sarcoidosis.
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan.
Tomomi
T
Nobashi
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan. ynakamo1@kuhp.kyoto-u.ac.jp.
Yuji
Y
Nakamoto
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan.
Takeshi
T
Kubo
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan.
Takayoshi
T
Ishimori
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8057, Japan.
Tomohiro
T
Handa
Department of Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8057, Japan.
Kiminobu
K
Tanizawa
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan.
Kohei
K
Sano
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8057, Japan.
Michiaki
M
Mishima
Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan.
Kaori
K
Togashi
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D012507:Sarcoidosis / Q000000981:diagnostic imaging*
D009942:Organometallic Compounds; C513399:gallium Ga 68 dotatate
DOTATOC-PET/CT; Ga-scintigraphy; Sarcoidosis; Somatostatin receptor scintigraphy