Synthesis and characterization of stimuli-responsive polypropylene containing N-vinylcaprolactam and N-vinylimidazole obtained by ionizing radiation.
Polypropylene films were grafted with thermo-responsive N-vinylcaprolactam and pH-responsive N-vinylimidazole polymers by means of gamma radiation using pre-irradiation and direct methods, in order to functionalize the films with thermo- and/or pH-responsiveness. The dependence of grafting yield on parameters such as co-monomer concentration, pre-irradiation dose, temperature, and reaction time was evaluated. The samples were characterized by Fourier transform infrared and X-ray photoelectron spectroscopies, differential scanning calorimetry, thermogravimetric analysis, swelling studies in different solvents, and water contact angle. The grafted copolymers presented thermo- and pH-sensitiveness, highlighting their potential as advanced biomaterials, capable of providing adequate environment for hosting and sustained release of antimicrobial drugs bearing cationic moieties, such as groups of diclofenac, while still exhibiting good cytocompatibility.
Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México, D.F. 04510, Mexico.
Edgar
E
Zavala-Lagunes
División de Ciencias Básicas e Ingeniería, Depto. de Ingeniería de Procesos e Hidráulica, Universidad Autónoma Metropolitana-Iztapalapa, Av. San Rafael Atlixco No. 186, México, D.F. 09340, Mexico.
Juan-Carlos
JC
Ruiz
Instituto de Pesquisas Energéticas e Nucleares (IPEN/CNEN-SP), Av. Prof. Lineu Prestes, 2242, Cidade Universitária, 05508-000 São Paulo, SP, Brazil.
Gustavo H C
GHC
Varca
Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México, D.F. 04510, Mexico. Electronic address: ebucio@nucleares.unam.mx.
Emilio
E
Bucio
D002152:Calorimetry, Differential Scanning; D002209:Caprolactam / Q000031:analogs & derivatives* / Q000737:chemistry*; D005720:Gamma Rays; D007093:Imidazoles / Q000737:chemistry*; D056951:Photoelectron Spectroscopy; D011108:Polymers / Q000737:chemistry*; D011126:Polypropylenes / Q000138:chemical synthesis*; D011839:Radiation, Ionizing; D012997:Solvents; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry; D013997:Time Factors; D014867:Water / Q000737:chemistry
D007093:Imidazoles; D011108:Polymers; D011126:Polypropylenes; D012997:Solvents; D014867:Water; C086861:poly-N-vinylcaprolactam; D002209:Caprolactam; C425704:N-vinylimidazole
N-vinylcaprolactam; N-vinylimidazole; Polypropylene films; Radiation-grafting; Stimuli-responsive copolymers