Transporter protein and drug resistance of Trypanosoma.
Trypanosoma infection is one of the most important infections in livestock and humans. One of the main problems of its therapeutic control and treatment is the resurgence of drug resistance. One of the most studied causes of such resistance is the function of its adenosine transporter gene. A trypanosomal gene TbAT1 from Trypanosoma brucei has been cloned in yeast to demonstrate its function in the transport of adenosine and trypanocidal agents. Drug resistant trypanosomes showed a defective TbAT1 variant; furthermore, deletion of the gene and set point mutations in the transporter gene has been demonstrated from isolates from relapse patients. The molecular understanding of the mechanism of action trypanocidal agents and function of transporter gene can lead to control of drug resistance of Trypanosomes.
College of Veterinary Science and Medicine, Central Luzon State University, Science City of Munoz 3120, Nueva Ecija, Philippines.
Noraine P
NP
Medina
Philippine Carabao Center National Headquarters and Gene Pool, Science City of Munoz 3120, Nueva Ecija, Philippines.|Affiliate Faculty, Department of Animal Science, College of Agriculture, Central Luzon State University, Science City of Munoz 3120, Nueva Ecija, Philippines.
Claro N
CN
Mingala
D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D004351:Drug Resistance / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014345:Trypanosoma / Q000187:drug effects* / Q000378:metabolism*
D002352:Carrier Proteins; D014344:Trypanocidal Agents