Positive effect of strontium-oxide layer on the osseointegration of moderately rough titanium surface in non-osteoporotic rabbits.
OBJECTIVE
To evaluate the effect of strontium-oxide layer on new bone formation and osseointegration of sandblasted large-grit double-acid-etched (SLA) implant.


METHODS
Strontium-oxide layer on the SLA surface was produced by hydrothermal treatment using a Sr-containing solution. The surface topographies, roughness, hardness values, chemical elements and ionic release of SLA and the strontium-containing SLA (Sr-SLA) surface were measured by special instruments separately. Sixty-four SLA and Sr-SLA implants were inserted into the proximal tibiae and femoral condyles of sixteen non-osteoporotic New Zealand white rabbits. The biological effects were evaluated by removal torque (RTQ) testing and histomorphometric analysis after 3 and 6 weeks of implantation.


RESULTS
The surface characteristics showed Sr-SLA surfaces with dotted nanostructures can release appropriate amount of strontium ions into surrounding tissue till 14 days. In vivo, the Sr-SLA implants presented significantly higher RTQ than SLA implants at 3 and 6 weeks (P < 0.05). The Sr-SLA implants presented higher bone-to-implant contact (BIC) than SLA implants in cortical bone at 3 and 6 weeks (P < 0.05). The bone area was slightly higher for the Sr-SLA implants at 3 and 6 weeks (P > 0.05).


CONCLUSIONS
The strontium-oxide layer on the SLA surface has the potential to improve implant osseointegration in non-osteoporotic rabbits.
Department of Oral Implantology, The Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Yan-Pin
YP
Fan
Department of Oral Implantology, The Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Xiao-Yi
XY
Chen
Department of oral Implantology, Xiamen Stomatology Hospital, Xiamen, China.
Yun
Y
Chen
Department of Oral Implantology, The Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Guo-Li
GL
Yang
Department of Oral Implantology, The Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Hui-Ming
HM
Wang
Department of Oral Implantology, The Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Fu-Ming
FM
He
D000818:Animals; D000069343:Bone-Implant Interface; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D008297:Male; D016348:Osseointegration / Q000187:drug effects*; D011817:Rabbits; D013324:Strontium; D013499:Surface Properties; D014025:Titanium
D015921:Dental Implants; D014025:Titanium; D013324:Strontium

in vivo
; dental implants; osseointegration; rabbit model; strontium; titanium