Melatonin influence in ovary transplantation: systematic review.
Melatonin is an indolamine produced by the pineal gland and it can exert a potent antioxidant effect. Its free radical scavenger properties have been used to advantage in different organ transplants in animal experiments. Several concentrations and administration pathways have been tested and melatonin has shown encouraging beneficial results in many transplants of organs such as the liver, lungs, heart, pancreas, and kidneys. The objective of the present study was to review the scientific literature regarding the use of melatonin in ovary transplantation. A systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was carried out using the Cochrane and Pubmed databases and employing the terms 'melatonin' AND 'ovary' AND 'transplantation.' After analysis, 5 articles were extracted addressing melatonin use in ovary transplants and involving 503 animals. Melatonin enhanced various graft aspects like morphology, apoptosis, immunological reaction, revascularization, oxidative stress, and survival rate. Melatonin's antioxidative and antiapoptotic properties seemingly produce positive effects on ovarian graft activity. Despite the promising results, further studies in humans need to be conducted to consolidate its use, as ovary transplantation for fertility preservation is gradually being moved from the experimental stage to a clinical setting.
Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255 - Cerqueira César, São Paulo, SP, 05403-000, Brazil. meshiroma@gmail.com.
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Shiroma
Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina, Universidade Federal do Pará, Av. Generalíssimo Deodoro, 01 - Umarizal, Belém, Pará, 66050-160, Brazil.
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Botelho
Laboratory of Molecular and Structural Gynecology, Faculdade de Medicina, Universidade de São Paulo, Avenida Doutor Arnaldo, 455 - Cerqueira César, São Paulo, SP, 01246-904, Brazil.
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Damous
Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.
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Baracat
Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.
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Soares
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D005260:Female; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D008550:Melatonin / Q000378:metabolism* / Q000494:pharmacology; D018919:Neovascularization, Physiologic / Q000187:drug effects; D016377:Organ Transplantation; D010053:Ovary / Q000187:drug effects / Q000378:metabolism* / Q000637:transplantation*; D018384:Oxidative Stress / Q000187:drug effects
D000975:Antioxidants; D008550:Melatonin
Melatonin; Ovary; Transplant