Maleimide-grafted cellulose nanocrystals as cross-linkers for bionanocomposite hydrogels.
This article deals with the preparation of bionanocomposite hydrogels from natural polymers and nanoentities, an emerging class of materials for biotechnological and biomedical applications. Herein, the applicability of the Diels-Alder "click" reaction to the design of bionanocomposite hydrogels from furan modified gelatin using maleimide-functionalized cellulose nanocrystals as multifunctional cocross-linkers is demonstrated. The functionalization of cellulose nanocrystals with maleimide moieties was confirmed by XPS. The swelling and rheological properties of the resulting bionanocomposite confirmed the formation of hydrogel networks with covalently embedded nanoentities. The Diels-Alder reaction resulted in the formation of stiffer networks with lower swelling ratios due to the formation of additional cross-linking points. The designed "click" strategy proved to be a promising candidate for the formation of fully renewable bionanocomposite hydrogels.
'Materials+Technologies' Group, Department of Chemical and Environmental Engineering, Polytechnic School, University of the Basque Country, Plaza Europa 1, 20018 Donostia-San Sebastián, Spain. Electronic address: clara.garcia@ehu.eus.
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García-Astrain
'Materials+Technologies' Group, Department of Chemical and Environmental Engineering, Polytechnic School, University of the Basque Country, Plaza Europa 1, 20018 Donostia-San Sebastián, Spain. Electronic address: kizkitza.gonzalez@ehu.eus.
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González
'Materials+Technologies' Group, Department of Chemical and Environmental Engineering, Polytechnic School, University of the Basque Country, Plaza Europa 1, 20018 Donostia-San Sebastián, Spain. Electronic address: taniagurrea@gmail.com.
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Gurrea
'Materials+Technologies' Group, Department of Chemical and Environmental Engineering, Polytechnic School, University of the Basque Country, Plaza Europa 1, 20018 Donostia-San Sebastián, Spain. Electronic address: olatz.guaresti@ehu.eus.
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Guaresti
'Materials+Technologies' Group, Department of Chemical and Environmental Engineering, Polytechnic School, University of the Basque Country, Plaza Europa 1, 20018 Donostia-San Sebastián, Spain. Electronic address: itxaso.algar@ehu.eus.
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Algar
'Materials+Technologies' Group, Department of Chemical and Environmental Engineering, Polytechnic School, University of the Basque Country, Plaza Europa 1, 20018 Donostia-San Sebastián, Spain. Electronic address: arantxa.eceiza@ehu.eus.
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Eceiza
'Materials+Technologies' Group, Department of Chemical and Environmental Engineering, Polytechnic School, University of the Basque Country, Plaza Europa 1, 20018 Donostia-San Sebastián, Spain. Electronic address: nagore.gabilondo@ehu.eus.
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Gabilondo
D001672:Biocompatible Materials / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D008301:Maleimides / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*
D001672:Biocompatible Materials; D020100:Hydrogels; D008301:Maleimides; C043592:maleimide; D002482:Cellulose
Bionanocomposite hydrogel; Cellulose nanocrystals; Diels-Alder; “Click” Chemistry