Association of leptin with orthostatic blood pressure changes in Parkinson's disease.
Leptin is involved in the regulation of blood pressure; however, no studies have evaluated the role of leptin in blood pressure changes during orthostatic stress in PD patients. The aim of this study was to determine whether plasma leptin levels influence orthostatic blood pressure changes in PD patients.



We enrolled 55 patients and 25 age-matched healthy controls in this study. Associations between head-up tilt test measurements and leptin levels were evaluated.



Systolic blood pressure changes during the head-up tilt tests were strongly correlated with leptin levels at baseline and at a 60-degree head-up tilt in PD patients, but not in control subjects. Multiple regression analysis also demonstrated that leptin levels were associated with orthostatic blood pressure changes.



These observations suggest that low leptin levels may be associated with orthostatic hypotension during the head-up tilt test in patients with PD. © 2016 International Parkinson and Movement Disorder Society.
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.|Department of Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
Tomohiko
T
Nakamura
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Masashi
M
Suzuki
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Akinori
A
Okada
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Junichiro
J
Suzuki
Division of Neurogenetics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Satoru
S
Hasegawa
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Haruki
H
Koike
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.|Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Masaaki
M
Hirayama
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Masahisa
M
Katsuno
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan. sobueg@med.nagoya-u.ac.jp.
Gen
G
Sobue
D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood*
D020738:Leptin
Parkinson's disease; autonomic dysfunction; leptin; orthostatic hypotension