Dietary Nitrate and Skeletal Muscle Contractile Function in Heart Failure.
Heart failure (HF) patients suffer from exercise intolerance that diminishes their ability to perform normal activities of daily living and hence compromises their quality of life. This is due largely to detrimental changes in skeletal muscle mass, structure, metabolism, and function. This includes an impairment of muscle contractile performance, i.e., a decline in the maximal force, speed, and power of muscle shortening. Although numerous mechanisms underlie this reduction in contractility, one contributing factor may be a decrease in nitric oxide (NO) bioavailability. Consistent with this, recent data demonstrate that acute ingestion of NO3 (-)-rich beetroot juice, a source of NO via the NO synthase-independent enterosalivary pathway, markedly increases maximal muscle speed and power in HF patients. This review discusses the role of muscle contractile dysfunction in the exercise intolerance characteristic of HF, and the evidence that dietary NO3 (-) supplementation may represent a novel and simple therapy for this currently underappreciated problem.
Cardiovascular Imaging Laboratory, Mallinckrodt Institute of Radiology, Department of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd. - Campus Box 8225, St. Louis, MO, 63110, USA. coggana@mir.wustl.edu.
Andrew R
AR
Coggan
Cardiovascular Imaging Laboratory, Mallinckrodt Institute of Radiology, Department of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd. - Campus Box 8225, St. Louis, MO, 63110, USA.|Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, 660 S. Euclid Ave. - Campus Box 8086, St. Louis, MO, 63110, USA.
Linda R
LR
Peterson
D000203:Activities of Daily Living; D027461:Beta vulgaris / Q000737:chemistry*; D001682:Biological Availability; D019587:Dietary Supplements; D000067030:Fruit and Vegetable Juices; D006333:Heart Failure / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009566:Nitrates / Q000008:administration & dosage*; D009569:Nitric Oxide / Q000493:pharmacokinetics*; D011788:Quality of Life
D009566:Nitrates; D009569:Nitric Oxide
Beetroot juice; Dietary nitrate; Heart failure; Muscle power; Muscle speed; Nitric oxide