Association of the HindIII Lipoprotein Lipase Gene Polymorphism with the Development of the Non-Biliary Acute Pancreatitis: a Pilot Study.
We studied the relationship between lipoprotein lipase (LPL) gene HindIII polymorphism and the development of acute pancreatitis in the Russian population. Whole blood samples were collected from 145 patients with acute non-biliary pancreatitis and 191 healthy individuals. Genotyping of LPL gene HindIII (rs320) polymorphism was performed by PCR with TaqMan assay. It was found that allele H+ (OR=0.63, 95%CI 0.41-0.96, p=0.03) and genotype H+/H+ (OR=1.79, 95%CI 1.06-3.04, p=0.03) were associated with the risk of acute non-biliary pancreatitis only in males. In this study, the relationship between HindIII polymorphism of LPL gene with the risk of acute non-biliary pancreatitis was revealed.
Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia. tass@list.ru.
T A
TA
Samgina
Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
O Yu
OY
Bushueva
Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
P M
PM
Nazarenko
Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
A V
AV
Polonikov
D000328:Adult; D016022:Case-Control Studies; D015252:Deoxyribonucleases, Type II Site-Specific / Q000737:chemistry; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000235:genetics*; D010865:Pilot Projects; D012150:Polymorphism, Restriction Fragment Length; D012306:Risk
D008071:Lipoprotein Lipase; D015252:Deoxyribonucleases, Type II Site-Specific
acute non-biliary pancreatitis; genetic Polymorphism; genetic predisposition; lipoprotein lipase