Adaptation of hybrid immunoaffinity LC-MS methods for protein bioanalysis in a Contract Research Organization.
Q2 Solutions, Bioanalytical and ADME Labs, 19 Brown Road, Ithaca, NY 14850, USA.
Barry R
BR
Jones
Munson Technology, LLC, Ithaca, NY, USA.
Gary A
GA
Schultz
D000818:Animals; D002846:Chromatography, Affinity / Q000379:methods*; D006801:Humans; D047468:Immunoprecipitation / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods*; D010455:Peptides / Q000032:analysis; D011506:Proteins / Q000032:analysis
D010455:Peptides; D011506:Proteins
high-resolution MS (HRMS); immunoaffinity (IA); immunoprecipitation (IP); microflow chromatography; nanoflow chromatography; sequential immunoprecipitation (sequential-IP); signature peptide; surrogate peptide