Serum C-reactive protein and S100A12 concentrations in dogs with hepatic disease.
OBJECTIVE
To describe serum C-reactive protein and S100A12 concentrations in dogs with hepatic disease and to determine whether there is a relationship between the concentration of either and the severity of hepatic necroinflammation.


METHODS
Serum C-reactive protein and S100A12 concentrations were measured in 46 dogs undergoing hepatic biopsy. Dogs were divided into three groups: congenital portosystemic shunts, chronic hepatitis and hepatic neoplasia. The histological severity of hepatic necroinflammation was scored.


RESULTS
C-reactive protein and S100A12 concentrations were greater than the upper limit of the reference intervals in 39 and 26% of dogs, respectively. There was no association of disease group with C-reactive protein (P=0·1733) or S100A12 (P=0·1513) concentrations. There was a positive correlation between serum C-reactive protein concentration and hepatic necroinflammatory activity (rs =0·428, P=0·006).


CONCLUSIONS
Increased serum C-reactive protein and S100A12 concentrations were observed in a subpopulation of dogs with various types of hepatic diseases, suggesting acute-phase inflammation and activation of phagocytic cells, respectively. Dogs with higher hepatic necroinflammatory activity scores tended to have higher serum C-reactive protein concentrations. Further studies are needed to confirm this finding in a larger group of dogs.
Gulf Coast Veterinary Specialists, Houston, Texas, 77027, USA.
S M
SM
Craig
Gulf Coast Veterinary Specialists, Houston, Texas, 77027, USA.
J K
JK
Fry
Department of Pathobiology, College of Veterinary Medicine & Biomedical Sciences, College Station, Texas, 77843-4474, USA.
A
A
Rodrigues Hoffmann
Gulf Coast Veterinary Specialists, Houston, Texas, 77027, USA.
P
P
Manino
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, College Station, Texas, 77843-4474, USA.
R M
RM
Heilmann
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, College Station, Texas, 77843-4474, USA.
J S
JS
Suchodolski
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, College Station, Texas, 77843-4474, USA.
J M
JM
Steiner
Gulf Coast Veterinary Specialists, Houston, Texas, 77027, USA.
H A
HA
Hottinger
Gulf Coast Veterinary Specialists, Houston, Texas, 77027, USA.
S L
SL
Hunter
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, College Station, Texas, 77843-4474, USA.
J A
JA
Lidbury
D000818:Animals; D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D004283:Dog Diseases / Q000097:blood* / Q000473:pathology; D004285:Dogs; D005260:Female; D008107:Liver Diseases / Q000097:blood*; D008297:Male; D011237:Predictive Value of Tests; D000067616:S100A12 Protein / Q000097:blood*; D012720:Severity of Illness Index
D015415:Biomarkers; D001798:Blood Proteins; D000067616:S100A12 Protein