Clinical and laboratory profile of Zika virus infection in dengue suspected patients: A case series.
The Zika virus (ZIKV) is an emerging arthropod-borne virus related to the dengue virus (DENV), and shows a similar clinical profile as other arboviral diseases, such as dengue and chikungunya virus (CHIKV). Historically, ZIKV has been associated with sporadic cases of human infection, but is now responsible for outbreaks worldwide. In Brazil, cases have been reported since 2015, with some cases causing severe disease.



To identify clinical symptoms of Zika in patients in Dengue suspected patients.



Description of a series of cases, wherein we analyzed 100 clinical samples collected from patients who exhibited acute febrile disease for ≤5days, from January to February 2016.



In this study, we report 13 cases of ZIKV infection in adults presenting dengue-like symptoms in a DENV endemic area. All patients presented with fever, with myalgia being the second most frequently observed symptom. Two patients had rashes, but none of them had conjunctivitis. Other less frequent manifestations included headache, arthralgia, diarrhea, and nausea.



The co-circulation of ZIKV and DENV is a serious public health concern, since it represents both a clinical and diagnostic challenge in endemic areas, as well as in the field of travel medicine.
São José do Rio Preto School of Medicine (FAMERP), Avenida Brigadeiro Faria Lima, 5416. Vila São Pedro. São José do Rio Preto, CEP: 15090-000, SP, Brazil. Electronic address: cassiafestofolete@gmail.com.
Cássia
C
Fernanda Estofolete
São José do Rio Preto School of Medicine (FAMERP), Avenida Brigadeiro Faria Lima, 5416. Vila São Pedro. São José do Rio Preto, CEP: 15090-000, SP, Brazil. Electronic address: anacarolinaterzian@gmail.com.
Ana Carolina Bernardes
AC
Terzian
Global Health and Tropical Medicine (GHTM), Universidade Nova de Lisboa, Rua da Junqueira Nº 100, 1349-008 Lisboa, Portugal. Electronic address: ricardo@ihmt.unl.pt.
Ricardo
R
Parreira
Global Health and Tropical Medicine (GHTM), Universidade Nova de Lisboa, Rua da Junqueira Nº 100, 1349-008 Lisboa, Portugal. Electronic address: aidaesteves@ihmt.unl.pt.
Aida
A
Esteves
São José do Rio Preto School of Medicine (FAMERP), Avenida Brigadeiro Faria Lima, 5416. Vila São Pedro. São José do Rio Preto, CEP: 15090-000, SP, Brazil. Electronic address: lucashardman@hotmail.com.
Lucas
L
Hardman
São José do Rio Preto Regional School of Medicine Foundation (FUNFARME), Avenida Brigadeiro Faria Lima, 5416. Vila São Pedro. São José do Rio Preto, SP, CEP: 15090-000, Brazil. Electronic address: greque@terra.com.br.
Gilmar Valdir
GV
Greque
Department of Biology, Institute of Biosciences, Letters, and Exact Sciences - São Paulo State University, São José do Rio Preto - (IBILCE/UNESP), Rua Cristóvão Colombo, 2265, CEP: 15054-000 - São José do Rio Preto, SP, Brazil. Electronic address: rahalp@yahoo.com.br.
Paula
P
Rahal
São José do Rio Preto School of Medicine (FAMERP), Avenida Brigadeiro Faria Lima, 5416. Vila São Pedro. São José do Rio Preto, CEP: 15090-000, SP, Brazil. Electronic address: mnogueira@famerp.br.
Maurício Lacerda
ML
Nogueira
D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D015331:Cohort Studies; D003715:Dengue / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000821:virology*; D003716:Dengue Virus / Q000235:genetics; D004196:Disease Outbreaks; D005260:Female; D005334:Fever; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis / Q000097:blood; D055815:Young Adult; D000071244:Zika Virus / Q000235:genetics; D000071243:Zika Virus Infection / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000821:virology*
D012367:RNA, Viral
Arbovirus; Chikungunya virus; Dengue virus; NS1; Zika virus