Management and treatment of Magnusiomyces capitatus (Geotrichum capitatum) pleural infection in a non-neutropenic patient with posaconazole. A new therapeutic opportunity?
Magnusiomyces capitatus may cause uncommon yet severe infections, especially in patients with haematologic disorders. Diagnosis may be difficult and time-consuming and newer approaches are required including the MALDI-TOF technique implemented with the detection of fungal antigens in the body fluids. The recommended treatment includes amphotericin B alone or in combination with flucytosine. We describe a case of a non-neutropenic patient with M. capitatus pleural infection, as identified by MALDI-TOF, positivity for galactomannan antigen in the BAL fluid, and successfully treated with oral posaconazole in single therapy.
Department of Molecular Medicine, Azienda Policlinico Umberto I, Sapienza University of Rome, Italy.
Grazia
G
Brunetti
Department of Molecular Medicine, Azienda Policlinico Umberto I, Sapienza University of Rome, Italy.
Valeria
V
Visconti
Department of Public Health Science and Infectious Disease, Azienda Policlinico Umberto I, Sapienza University of Rome, Italy.
Maria Cristina
MC
Ghezzi
Department of Thoracic Surgery, Azienda Policlinico Umberto I, Sapienza University of Rome, Italy.
Sara
S
Mantovani
Department of Tropical Medicine, Azienda Policlinico Umberto I, Sapienza University of Rome, Italy.
Giancarlo
G
Ferretti
Department of Public Health Science and Infectious Disease, Azienda Policlinico Umberto I, Sapienza University of Rome, Italy.
Giammarco
G
Raponi
D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D005847:Geotrichosis / Q000188:drug therapy* / Q000382:microbiology*; D005848:Geotrichum; D006801:Humans; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole
Galactomannan antigen; MALDI-TOF identification; Magnusiomyces capitatus; Pleural infection; Posaconazole