Role of Progenitor Cells in Liver Regeneration after Subtotal Resection.
In the liver of rats subjected to subtotal liver resection (80% organ weight), the expression of sox9 gene and SOX9 protein content increased and cells with hepatocyte morphology expressing SOX9 appeared; the proportion of cells expressing cytokeratin-19 also increased. Based on these data, we cannot completely exclude the involvement of resident progenitor cells and hepatocyte reprogramming in liver regeneration after subtotal resection, however, the contribution of these processes seems to be insignificant. The leading mechanism of liver mass recovery after subtotal resection is proliferation of hepatocytes.
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.|Institute of Human Morphology, Moscow, Russia.|N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
A V
AV
El'chaninov
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia. fatkhudinov@gmail.com.|Institute of Human Morphology, Moscow, Russia. fatkhudinov@gmail.com.|N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia. fatkhudinov@gmail.com.
T Kh
TKh
Fatkhudinov
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.|Institute of Human Morphology, Moscow, Russia.
E Yu
EY
Kananykhina
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.|Institute of Human Morphology, Moscow, Russia.
N Yu
NY
Usman
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.|Institute of Human Morphology, Moscow, Russia.
I V
IV
Arutyunyan
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.|Institute of Human Morphology, Moscow, Russia.|N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
A V
AV
Makarov
N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
A V
AV
Bykov
Institute of Human Morphology, Moscow, Russia.
G V
GV
Bolshakova
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
G T
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Sukhikh
D000818:Animals; D021461:Animals, Outbred Strains; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D049109:Cell Proliferation; D000074049:Cytokine TWEAK; D006498:Hepatectomy; D022781:Hepatocytes / Q000502:physiology*; D008099:Liver / Q000502:physiology* / Q000601:surgery; D008115:Liver Regeneration; D008565:Membrane Proteins / Q000378:metabolism; D008938:Mitosis; D009929:Organ Size; D017207:Rats, Sprague-Dawley; D055758:SOX9 Transcription Factor / Q000378:metabolism; D013234:Stem Cells / Q000502:physiology*; D048069:Tumor Necrosis Factors / Q000378:metabolism
D051017:Apoptosis Regulatory Proteins; D000074049:Cytokine TWEAK; D008565:Membrane Proteins; D055758:SOX9 Transcription Factor; C497771:Tnfsf12 protein, rat; D048069:Tumor Necrosis Factors
liver; progenitor cells; regeneration; subtotal resection