A Randomized, Evaluator-Blinded, Split-Face Comparison Study of the Efficacy and Safety of a Novel Mannitol Containing Monophasic Hyaluronic Acid Dermal Filler for the Treatment of Moderate to Severe Nasolabial Folds.
BACKGROUND
Mannitol containing monophasic filler with higher crosslinking has not been well studied for moderate and severe nasolabial fold (NLF) correction.


OBJECTIVE
To compare the efficacy and safety of a novel mannitol containing hyaluronic acid (HA) filler (HA-G) with biphasic HA filler (HA-P) for moderate and severe NLF correction.


METHODS
Thirteen subjects with symmetric moderate to severe NLF received HA-G (in one NLF) and HA-P (in other NLF) and were evaluated for 24 weeks.


RESULTS
At both 12 and 24 weeks, the mean improvement in Genzyme 6-point grading scale from baseline was significantly greater in the side of face that was treated with HA-G than HA-P (1.96±0.91 vs. 1.54±0.73 at week 12; p=0.044, 1.88±0.78 vs. 1.3±0.79 at week 24; p=0.027, respectively). At 12 weeks, the mean Global Aesthetic Improvement Scale score was 2.92±0.93 for HA-G and 2.31±0.95 for HA-P (p=0.008). Both fillers were well tolerated.


CONCLUSIONS
The HA filler HA-G provides better efficacy and similar local tolerability compared with HA-P in 6 months following treatment for moderate and severe NLF.
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Byung Wook
BW
Kim
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Ik Jun
IJ
Moon
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Woo Jin
WJ
Yun
Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Bo Young
BY
Chung
Bright and Clear Dermatology Clinic, Seoul, Korea.
Sang Duck
SD
Kim
Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Ga-Young
GY
Lee
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Sung Eun
SE
Chang
Dermal filler; Hyaluronic acid; Mannitol; Nasolabial fold