Gut barrier function and systemic endotoxemia after laparotomy or laparoscopic resection for colon cancer: A prospective randomized study.
OBJECTIVE
The gut barrier is altered in certain pathologic conditions (shock, trauma, or surgical stress), resulting in bacterial and/or endotoxin translocation from the gut lumen into the systemic circulation. In this prospective randomized study, we investigated the effect of surgery on intestinal permeability (IP) and endotoxemia in patients undergoing elective colectomy for colon cancer by comparing the laparoscopic with the open approach.


METHODS
A hundred twenty-three consecutive patients underwent colectomy for colon cancer: 61 cases were open resection (OR) and 62 cases were laparoscopic resection (LR). IP was measured preoperatively and at days 1 and 3 after surgery. Serial venous blood sample were taken at 0, 30, 60, 90, 120, and 180 min, and at 12, 24, and 48 h after surgery for endotoxin measurement.


RESULTS
IP was significantly increased in the open and closed group at day 1 compared with the preoperative level (P < 0.05), but no difference was found between laparoscopic and open surgery group. The concentration endotoxin systemic increased significantly in the both groups during the course of surgery and returned to baseline levels at the second day. No difference was found between laparoscopic and open surgery. A significant correlation was observed between the maximum systemic endotoxin concentration and IP measured at day 1 in the open group and in the laparoscopic group.


CONCLUSIONS
An increase in IP, and systemic endotoxemia were observed during the open and laparoscopic resection for colon cancer, without significant statistically difference between the two groups.
Department of Surgery, University of L'Aquila, L'Aquila, Italy.
Mario
M
Schietroma
Department of Surgery, University of L'Aquila, L'Aquila, Italy.
Beatrice
B
Pessia
Department of Surgery, University of L'Aquila, L'Aquila, Italy.
Francesco
F
Carlei
Department of Surgery, University of L'Aquila, L'Aquila, Italy.
Emanuela Marina
EM
Cecilia
Department of Surgery, University of L'Aquila, L'Aquila, Italy.
Gianfranco
G
Amicucci