Updates on Therapeutic Strategies Against Candida (and Aspergillus) Biofilm Related Infections.
Fungal biofilm related infections are commonly associated with medical devices with biofilms contributing to the virulence of the involved fungal species. If infection does occur, removal of medical device is often warranted. However, this is not always possible. Moreover, biofilm associated infections are often resistant to antifungals and host immunity. Therefore, a need for new agents and strategies to combat these devastating infections is needed. Although no randomized clinical trials have been conducted or are likely to be conducted in the future, the Infectious Disease Society of America (IDSA) and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) utilized available published data and clinical experience of the infectious disease community to propose strategies to treat biofilm associated devise infections. In this chapter we describe the emerging therapies for biofilm related infections.
Department of Dermatology, Center for Medical Mycology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, 44106, USA.
Fuad Kamel
FK
Muakkassa
Department of Dermatology, Center for Medical Mycology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, 44106, USA. Mahmoud.Ghannoum@Case.edu.
Mahmoud
M
Ghannoum
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D001230:Aspergillus / Q000187:drug effects* / Q000502:physiology; D018441:Biofilms / Q000187:drug effects*; D002175:Candida / Q000187:drug effects* / Q000502:physiology; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans
D000935:Antifungal Agents