The Possible Role of Toll-Like Receptor 4 in the Pathology of Stroke.
Stroke is a prevalent and dangerous health problem, which triggers an intense inflammatory response to Toll-like receptor (TLR) activation. TLRs are the essential components of the response of the innate immunity system, and, therefore, they are one of the key factors involved in recognizing pathogens and internal ligands. Among TLRs, TLR4 significantly participates in the induction of inflammation and brain functions; hence, it has been hypothesized that this molecule is associated with several immune-related brain diseases such as stroke. It has also been proved that animals with TLR4 deficiency have higher protection against ischemia and that the absence of TLR4 reduces neuroinflammation and injuries associated with brain trauma. TLR4 deficiency may play a neuroprotective role in the occurrence of stroke. This article reviews recent information regarding the impact of TLR4 on the pathogenicity of stroke.
Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences,Rafsanjan, Iran.
Elham
E
Hakimizadeh
Mohammad
M
Kazemi Arababadi
Ali
A
Shamsizadeh
Ali
A
Roohbakhsh
Mohammad
M
Allahtavakoli
D000818:Animals; D007113:Immunity, Innate; D007249:Inflammation; D020521:Stroke; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D051217:Toll-Like Receptor 9
D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D051217:Toll-Like Receptor 9