Role of atopy in chronic rhinosinusitis with nasal polyps: does an atopic condition affect the severity and recurrence of disease?
BACKGROUND
The role of atopy in chronic rhinosinusitis is unclear: it is particularly controversial in chronic rhinosinusitis with nasal polyps.


METHODS
A prospective study of 210 patients with chronic rhinosinusitis with nasal polyps was performed. Patient demographics, visual analogue scale scores, Lund-Kennedy endoscopy scores, Lund-Mackay computed tomography scores, serum total immunoglobulin E levels, serum eosinophil cationic protein (ECP) levels and Phadiatop test findings were analysed.


RESULTS
There were no significant differences in age, sex, visual analogue scale score, Lund-Mackay computed tomography score, total serum immunoglobulin E level, serum ECP level or Phadiatop test results between patients with primary and recurrent chronic rhinosinusitis with nasal polyps. A total of 99 patients (47 per cent) had positive atopy tests. No significant differences in sex, visual analogue scale score, Lund-Kennedy endoscopy score, Lund-Mackay computed tomography score or recurrence rates were found between atopic and non-atopic patients; however, atopic patients were significantly younger than non-atopic patients. Atopy status did not correlate with disease severity.


CONCLUSIONS
There was no association between atopy status and either disease severity or recurrence in patients with chronic rhinosinusitis with nasal polyps, although atopic patients were younger than non-atopic patients.
Department of Otorhinolaryngology - Head and Neck Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China.
Q C
QC
Li
Department of Otorhinolaryngology - Head and Neck Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China.
K J
KJ
Cheng
Department of Otorhinolaryngology - Head and Neck Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China.
F
F
Wang
Department of Otorhinolaryngology - Head and Neck Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,China.
S H
SH
Zhou
D000328:Adult; D002908:Chronic Disease; D047150:Eosinophil Cationic Protein / Q000276:immunology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000000981:diagnostic imaging / Q000276:immunology*; D011446:Prospective Studies; D012008:Recurrence; D012220:Rhinitis / Q000000981:diagnostic imaging / Q000276:immunology*; D012720:Severity of Illness Index; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000276:immunology*; D014057:Tomography, X-Ray Computed
D007073:Immunoglobulin E; D047150:Eosinophil Cationic Protein; C479220:RNASE3 protein, human
Allergy and Immunology; Hypersensitivity; Nasal Polyps; Recurrence; Severity of Illness Index; Sinusitis