MicroRNA hsa-miR-4674 in Hemolysis-Free Blood Plasma Is Associated with Distant Metastases of Prostatic Cancer.
We analyzed microRNA profile in hemolysis-free blood plasma of patients with prostatic cancer. The metastatic form of prostatic cancer was found to be associated with increased levels of hsa-miR-22-3p, hsa-miR-663a, and hsa-miR-4674 in comparison with non-metastatic form. Common candidate target genes of these microRNA include JUNB, KMT2A, and XPO6.
BioClinicum Research and Development Center, Moscow, Russia.
E N
EN
Knyazev
BioClinicum Research and Development Center, Moscow, Russia.
T R
TR
Samatov
National Medical Research Radiology Center, Moscow, Russia.
K A
KA
Fomicheva
National Medical Research Radiology Center, Moscow, Russia.
K M
KM
Nyushko
National Medical Research Radiology Center, Moscow, Russia.
B Ya
BY
Alekseev
BioClinicum Research and Development Center, Moscow, Russia. mshkurnikov@imscs.msu.ru.|National Medical Research Radiology Center, Moscow, Russia. mshkurnikov@imscs.msu.ru.
M Yu
MY
Shkurnikov
D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D006461:Hemolysis; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D009362:Neoplasm Metastasis; D064129:Prostatic Neoplasms, Castration-Resistant / Q000097:blood* / Q000473:pathology
D014408:Biomarkers, Tumor; C000589191:MIRN4674 microRNA, human; D035683:MicroRNAs
blood plasma; metastases; microRNA; microarray analysis; prostatic cancer