Characteristics and Risk Factors for Fatality in Patients with Dengue Hemorrhagic Fever, Taiwan, 2014.
An unprecedented dengue outbreak involving more than 15,000 infections, including 136 dengue hemorrhagic fever (DHF) cases and 20 fatalities, occurred in Taiwan in 2014. The median age of the DHF cases was 71 years (range: 4-92 years) and most of them (N = 100, 73.5%) had comorbidities, of which the majority were hypertension (56%) and diabetes mellitus (DM; 27%). Only approximately half of the DHF cases (59/136) were classified as severe dengue, based on the 2009 WHO-revised dengue classification. The fatality rate for this DHF outbreak was 14.7%. DM (odds ratio [OR] = 3.60, 95% confidence interval [CI] = 1.22-10.63) and presentation with severe plasma leakage (OR = 6.42, 95% CI = 1.76-23.63) were independent risk factors for fatality.
Office of Preventive Medicine, Centers for Disease Control, Taipei, Taiwan.
Hsin-Yi
HY
Wei
Center for Diagnostics and Vaccine Development, Centers for Disease Control, Taipei, Taiwan.
Pei-Yun
PY
Shu
Office of Preventive Medicine, Centers for Disease Control, Taipei, Taiwan. mnhung@cdc.gov.tw.
Min-Nan
MN
Hung
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D003716:Dengue Virus / Q000302:isolation & purification / Q000472:pathogenicity*; D003920:Diabetes Mellitus / Q000503:physiopathology; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D019595:Severe Dengue / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis; D013624:Taiwan / Q000453:epidemiology