Dopamine transporter mutant animals: a translational perspective.
The dopamine transporter (DAT) plays an important homeostatic role in the control of both the extracellular and intraneuronal concentrations of dopamine, thereby providing effective control over activity of dopaminergic transmission. Since brain dopamine is known to be involved in numerous neuropsychiatric disorders, investigations using mice with genetically altered DAT function and thus intensity of dopamine-mediated signaling have provided numerous insights into the pathology of these disorders and novel pathological mechanisms that could be targeted to provide new therapeutic approaches for these disorders. In this brief overview, we discuss recent investigations involving animals with genetically altered DAT function, particularly focusing on translational studies providing new insights into pathology and pharmacology of dopamine-related disorders. Perspective applications of these and newly developed models of DAT dysfunction are also discussed.
a Institute of Translational Biomedicine, St. Petersburg State University , St. Petersburg , Russia ;|b Skolkovo Institute of Science and Technology , Skolkovo , Moscow Region , Russia ;
Evgeniya V
EV
Efimova
a Institute of Translational Biomedicine, St. Petersburg State University , St. Petersburg , Russia ;|b Skolkovo Institute of Science and Technology , Skolkovo , Moscow Region , Russia ;
Raul R
RR
Gainetdinov
a Institute of Translational Biomedicine, St. Petersburg State University , St. Petersburg , Russia ;|c Department of Neurobiology and Anatomy , Wake Forest School of Medicine , Winston-Salem , NC , USA.
Evgeny A
EA
Budygin
a Institute of Translational Biomedicine, St. Petersburg State University , St. Petersburg , Russia ;
Tatyana D
TD
Sotnikova
D000818:Animals; D004195:Disease Models, Animal; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D051379:Mice; D057170:Translational Research, Biomedical
D050483:Dopamine Plasma Membrane Transport Proteins
Addiction; Parkinson’s disease; attention deficit hyperactivity disorder; dopamine transporter; knockout; schizophrenia