Image-guided intensity-modulated radiotherapy for refractory bilateral breast cancer in a patient with extensive cutaneous metastasis in the chest and abdominal walls.
Treatment for bilateral breast cancer with chest wall and abdominal skin invasion normally involves conventional radiotherapy (RT); however, conventional RT provides inadequate target volume coverage and excessive treatment of large volumes of normal tissue. Helical tomotherapy (HT) has the ability to deliver continuous craniocaudal irradiation that suppresses junction problems and provides good conformity of dose distribution. A 47-year-old female with stage IV bilateral breast cancer with chest wall and pectoralis major muscle invasion, lymphadenopathy, bilateral pleural effusion, and multiple bone metastases received chemotherapy and target therapy beginning in January 2014; 4 months after the initiation of chemotherapy, computed tomography revealed progression of chest and abdominal wall invasion. A total dose of 70.2 Gy was delivered to both breasts, the chest wall, the abdominal wall, and the bilateral supraclavicular nodal areas in 39 fractions via HT. The total planning target volume was 4,533.29 cm(3). The percent of lung volume receiving at least 20 Gy (V20) was 28%, 22%, and 25% for the right lung, left lung, and whole lung, respectively. The mean dose to the heart was 8.6 Gy. Follow-up computed tomography revealed complete response after the RT course. Grade 1 dysphagia, weight loss, grade 2 neutropenia, and grade 3 dermatitis were noted during the RT course. Pain score decreased from 6 to 1. No cardiac, pulmonary, liver, or intestinal toxicity developed during treatment or follow-up. Concurrent HT with or without systemic treatment could be a safe salvage therapy for chemorefractory locally advanced breast cancer patients with extensive cutaneous metastasis.
Division of Radiation Oncology, Department of Radiology, Yuan-Ze University, Taoyuan, Taiwan.
Yueh-Feng
YF
Lu
Division of Oncology and Hematology, Department of Medicine, Yuan-Ze University, Taoyuan, Taiwan.
Yu-Chin
YC
Lin
Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Yuan-Ze University, Taoyuan, Taiwan; Department of Electrical Engineering, Yuan-Ze University, Taoyuan, Taiwan.
Kuo-Hsin
KH
Chen
Division of Radiation Oncology, Department of Radiology, Yuan-Ze University, Taoyuan, Taiwan.
Pei-Wei
PW
Shueng
Division of Radiation Oncology, Department of Radiology, Yuan-Ze University, Taoyuan, Taiwan.
Hsin-Pei
HP
Yeh
Division of Radiation Oncology, Department of Radiology, Yuan-Ze University, Taoyuan, Taiwan; Department of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Chen-Hsi
CH
Hsieh
bilateral breast cancer; cutaneous metastasis; helical tomotherapy; palliative; toxicity