Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N-Aryl Glycine Esters with Terminal Alkynes.
A copper-catalyzed enantioselective cross-coupling of a Csp3-H moiety (N-aryl glycine ester) with a Csp-H component (terminal alkyne) using molecular oxygen as the terminal oxidant is described for the first time. The sustainable method provides an efficient and environmentally friendly approach to rapidly prepare a diverse array of optically active non-natural α-amino acids.
School of Pharmaceutical Sciences, Shandong University , Jinan 250012, China.|College of Chemistry and Chemical Engineering, Xuchang University , Xuchang 461000, China.
Zhiyu
Z
Xie
School of Pharmaceutical Sciences, Shandong University , Jinan 250012, China.
Xigong
X
Liu
School of Pharmaceutical Sciences, Shandong University , Jinan 250012, China.|School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, China.
Lei
L
Liu