Etiologic Agents and Antifungal Susceptibility of Oral Candidosis from Romanian patients with HIV-infection or type 1 diabetes mellitus.
This is the first Romanian investigation of oral candidosis in patients suffering of HIV-infection or type 1 diabetes mellitus (T1DM). Candida albicans was the dominant species in both types of isolates: n = 14 (46.7%) in T1DM, n = 60 (69.8%) in HIV. The most frequent non-albicans Candida spp. were Candida kefyr (n = 6; 20%) in T1DM and Candida dubliniensis (n = 8; 9.3%) in HIV. Resistance to fluconazole was detected only in the HIV non-albicans Candida group (n = 8; 9.3%). All isolates were susceptible to VOR. The experimental drug MXP had MIC values equal or close to the ones of VOR. Echinocandin resistance was more frequent than azole resistance.
Bogdan
B
Minea
Valentin
V
Nastasa
Anna
A
Kolecka
Magdalena
M
Mares
Narcisa
N
Marangoci
Irina
I
Rosca
Mariana
M
Pinteala
Monica
M
Hancianu
Mihai
M
Mares
D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000145:classification / Q000187:drug effects*; D002180:Candidiasis, Oral / Q000382:microbiology*; D048909:Diabetes Complications / Q000382:microbiology*; D003922:Diabetes Mellitus, Type 1; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008826:Microbial Sensitivity Tests; D012383:Romania / Q000453:epidemiology; D014230:Triazoles / Q000494:pharmacology
D000935:Antifungal Agents; D014230:Triazoles; D015725:Fluconazole