The genetics of exceptional longevity: Insights from centenarians.
As the world population ages, so the prevalence increases of individuals aged 100 years or more, known as centenarians. Reaching this age has been described as exceptional longevity (EL) and is attributed to both genetic and environmental factors. Many genetic variations known to affect life expectancy exist in centenarians. This review of studies conducted on centenarians and supercentenarians (older than 110 years) updates knowledge of the impacts on longevity of the twenty most widely investigated single nucleotide polymorphisms (SNPs).
Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain; GIDFYS, Department of Health Sciences, European University Miguel de Cervantes, Valladolid, Spain.
Alejandro
A
Santos-Lozano
School of Health Sciences, University of León, Spain.
Ana
A
Santamarina
Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain; European University of Madrid, Madrid, Spain.
Helios
H
Pareja-Galeano
Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
Fabian
F
Sanchis-Gomar
Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
Carmen
C
Fiuza-Luces
IRyS Group, Physical Education School, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
Carlos
C
Cristi-Montero
Complejo Asistencial Universitario de León, León, Spain.
Aranzazu
A
Bernal-Pino
Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain; European University of Madrid, Madrid, Spain.
Alejandro
A
Lucia
Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain; Departamento de Fisiatría y Enfermería, Facultad de Ciencias de la Salud y del Deporte, GENUD (Growth, Exercise, Nutrition and Development) research group, Instituto Agroalimentario de Aragón -IA2- (Universidad de Zaragoza-CITA), Zaragoza, Spain. Electronic address: nuria.garatachea@unizar.es.
Nuria
N
Garatachea
D000369:Aged, 80 and over; D006801:Humans; D008017:Life Expectancy; D008136:Longevity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
Genetics; Longevity