Radiologically isolated syndrome: An update on a rare entity.
Our understanding of radiologically isolated syndrome (RIS) is evolving, as new data emerge on the clinical characterization and the pathophysiological nature of this rare entity. This topical review aims to (1) outline state-of-the-art clinical and magnetic resonance imaging findings of RIS research; (2) raise the main obstacles to RIS research; (3) discuss the most controversial issues of current RIS findings; and (4) highlight potential strategies for upcoming research studies.
Department of Neurology, University Hospital "12 de Octubre," Madrid, Spain.
Andrés
A
Labiano-Fontcuberta
Department of Neurology, University Hospital "12 de Octubre," Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain/Department of Medicine, Complutense University of Madrid, Madrid, Spain jbenitol67@gmail.com.
Julián
J
Benito-León
D006801:Humans; D056784:Leukoencephalopathies / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D013577:Syndrome
MRI; Radiologically isolated syndrome; clinical; review