DNA Replication-A Matter of Fidelity.
The fidelity of DNA replication is determined by many factors, here simplified as the contribution of the DNA polymerase (nucleotide selectivity and proofreading), mismatch repair, a balanced supply of nucleotides, and the condition of the DNA template (both in terms of sequence context and the presence of DNA lesions). This review discusses the contribution and interplay between these factors to the overall fidelity of DNA replication.
Department of Medical Biochemistry and Biophysics, Umeå University, SE 901 87 Umeå, Sweden; Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, NY 10016, USA.
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Ganai
Department of Medical Biochemistry and Biophysics, Umeå University, SE 901 87 Umeå, Sweden. Electronic address: erik.tm.johansson@umu.se.
Erik
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Johansson
D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004247:DNA / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D004249:DNA Damage; D053843:DNA Mismatch Repair; D045643:DNA Repair Enzymes / Q000378:metabolism; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D042822:Genomic Instability; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D004247:DNA; D004259:DNA-Directed DNA Polymerase; D045643:DNA Repair Enzymes