Preventive Effect of Green Tea Polyphenols against Dental Caries in Conventional Rats.
The effects of green tea polyphenols, inhibitors of various biological activities of cariogenic bacteria in vitro, on caries development were examined using conventional rats. A total of 96 male rats were divided into 8 groups and the rats in the test groups were given tea polyphenols ranging from 0.1% to 0.5% in their cariogenic diet or drinking water for 40 days. Total fissure caries lesions was significantly reduced by the addition of tea polyphenols to the diet or in the drinking water. Diet containing 0.1% tea polyphenols demonstrated about 40% reduction of total fissure caries lesions. No toxic effect of tea polyphenols on rats were observed under these experimental conditions.
a Central Research Laboratories of Taiyo Kagaku, Co., Ltd., 1-3, Takaramachi, Yokkaichi-shi , Mie 510 , Japan.
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Sakanaka
a Central Research Laboratories of Taiyo Kagaku, Co., Ltd., 1-3, Takaramachi, Yokkaichi-shi , Mie 510 , Japan.|b Department of Preventive Dentistry , Tokyo Medical and Dental University, Yushima, Bunkyo-ku , Tokyo 113 , Japan.
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Shimura
a Central Research Laboratories of Taiyo Kagaku, Co., Ltd., 1-3, Takaramachi, Yokkaichi-shi , Mie 510 , Japan.
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Aizawa
a Central Research Laboratories of Taiyo Kagaku, Co., Ltd., 1-3, Takaramachi, Yokkaichi-shi , Mie 510 , Japan.
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Kim
a Central Research Laboratories of Taiyo Kagaku, Co., Ltd., 1-3, Takaramachi, Yokkaichi-shi , Mie 510 , Japan.|c Department of Biotechnology , Fukuyama University, 985 Higashimura-cho , Fukuyama-shi , Hiroshima 729-02 , Japan.
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Yamamoto