Molecularly imprinted polymer-based bulk optode for the determination of itopride hydrochloride in physiological fluids.
We report here for the first time on the use of Molecularly Imprinted Polymers as modifiers in bulk optodes, Miptode, for the determination of a pharmaceutical compound, itopride hydrochloride as an example in a concentration range of 1×10(-1)-1×10(-4)molL(-1). In comparison to the optode containing the ion exchanger only (Miptode 3), the optode containing the ion exchanger and the MIP particles (Miptode 2) showed improved selectivity over the most lipophilic species, Na(+) and K(+), by more than two orders of magnitude. For instance, the optical selectivity coefficients using Miptode 2, [Formula: see text] , were as follow: NH4(+)˂-6; Na(+)=-4.0, which were greatly enhanced in comparison with that obtained by Miptode 3. This work opens a new avenue for using miptodes for the determination of all the pharmaceutical preparations without the need for the development of new ionophores.
Chemistry Department, Faculty of Science, Cairo University, Gamaa Street, 12613 Giza, Egypt. Electronic address: fatehy@sci.cu.edu.eg.
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Abdel-Haleem
Chemistry Department, Faculty of Science, Cairo University, Gamaa Street, 12613 Giza, Egypt.
Adel
A
Madbouly
Chemistry Department, Faculty of Science, Cairo University, Gamaa Street, 12613 Giza, Egypt. Electronic address: rashaelnashar@gmail.com.
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El Nashar
Chemistry Department, Faculty of Science, Cairo University, Gamaa Street, 12613 Giza, Egypt.
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Abdel-Ghani
D001549:Benzamides / Q000032:analysis / Q000652:urine*; D001593:Benzyl Compounds / Q000032:analysis / Q000652:urine*; D002800:Cholinesterase Inhibitors / Q000032:analysis / Q000652:urine*; D006801:Humans; D007476:Ionophores / Q000737:chemistry; D054802:Molecular Imprinting / Q000379:methods*; D011108:Polymers / Q000737:chemistry*
D001549:Benzamides; D001593:Benzyl Compounds; D002800:Cholinesterase Inhibitors; D007476:Ionophores; D011108:Polymers; C102254:itopride
Bulk optode; Itopride hydrochloride; Miptode; Molecularly imprinted polymer