MoS2/reduced graphene oxide as active hybrid material for the electrochemical detection of folic acid in human serum.
In this study, a new matrix based on a molybdenum disulfide-reduced graphene oxide hybrid (MoS2-rGO) was prepared and characterized. Modification of a glassy carbon electrode (GCE) with MoS2-rGO (MG) using drop casting allowed for the selective analysis of folic acid in the presence of a variety of interference species with a limit of detection of 10nM, a linear range between 0.01μM and 100μM with a sensitivity of 14µAµM(-1). In addition, the analytical performance of the proposed sensor was successfully conducted for the determination of folic acid in human serum samples, making MG-GC electrodes promising interfaces for bio-electrochemical applications.
Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR CNRS 8520, Lille1 University, Avenue Poincaré-BP60069, 59652 Villeneuve d'Ascq, France; Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. Electronic address: fchekin@yahoo.com.
Fereshteh
F
Chekin
Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR CNRS 8520, Lille1 University, Avenue Poincaré-BP60069, 59652 Villeneuve d'Ascq, France.
Florina
F
Teodorescu
Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR CNRS 8520, Lille1 University, Avenue Poincaré-BP60069, 59652 Villeneuve d'Ascq, France.
Yannick
Y
Coffinier
State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, 3888 Dong Nanhu Road, Changchun 130033, China.
Guo-Hui
GH
Pan
Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR CNRS 8520, Lille1 University, Avenue Poincaré-BP60069, 59652 Villeneuve d'Ascq, France.
Alexandre
A
Barras
Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR CNRS 8520, Lille1 University, Avenue Poincaré-BP60069, 59652 Villeneuve d'Ascq, France.
Rabah
R
Boukherroub
Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR CNRS 8520, Lille1 University, Avenue Poincaré-BP60069, 59652 Villeneuve d'Ascq, France. Electronic address: sabine.szunerits@univ-lille1.fr.
Sabine
S
Szunerits
D015374:Biosensing Techniques / Q000379:methods; D004220:Disulfides / Q000737:chemistry; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D005492:Folic Acid / Q000097:blood*; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D008982:Molybdenum / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*
D004220:Disulfides; D010087:Oxides; D006108:Graphite; D008982:Molybdenum; D005492:Folic Acid; C082964:molybdenum disulfide
Differential pulse voltammetry; Folic acid; Human serum; Molybdenum disulfide; Reduced graphene oxide