[Expression of phosphatase and tensin homology deleted on chromosometen (PTEN) in squamous-cell lung cancer and its clinical significance].
OBJECTIVE
To explore the expression of PTEN in squamous-cell lung cancer(SQCLC) and its clinical significance.


METHODS
A total of 50 patients with SQCLC, including 43 males, 7 females, aged 40 to 83(average age 66 ) years, in Meitan General Hospital from May 2009 to July 2013 were included. Tumor adjacent tissues from 10 patients, including 9 males, 1 female, aged 42 to 79 (average age 59 )years, and 13 patients with benign pulmonary disease tissues, including 11 males, 2 females, aged 34 to 76 (average age 58 ) years were also included as the controls. The expression of PTEN protein was detected by using immunohistochemistry (S-P)method and compared among SQCLC tissues tumor adjacent tissues and benign disease tissues. The correlations of expression of PTEN protein with gender, age, smoking status, lymph node metastasis, clinical stages and differentiation grades were performed.


RESULTS
(1) PTEN expression was low in 50 cases SQCLC, while there was a high expression in the tumor adjacent tissues and benign disease tissues. The PTEN protein positive rate of the SQCLC cases (20%, 10/50) was significantly lower than that of cases of tumor adjacent tissues and benign disease tissues (8/10, 12/13), χ(2)=23.542, P<0.01. (2) In the SQCLC group, the expression of PTEN protein was significantly related to differentiation grades and lymph node metastasis (P<0.05), but not gender, age, smoking status, and clinical stages (P>0.05).


CONCLUSIONS
The lower expression of PTEN in SQCLC was associated with high degree of malignancy and lymph node metastasis. The lost of expression of PTEN may serve as a marker for evaluation of malignancy and an independent factor for prognosis.
Department of Respiratory Medicine, Meitan General Hospital, Beijing 100028, China.
Y N
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Li
Y Z
YZ
Zhou
N
N
Zhang
H W
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Wang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D011379:Prognosis
D015415:Biomarkers; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human