Docetaxel-induced radiation recall dermatitis : A case report and literature review.
Radiation recall dermatitis (RRD) refers to an acute inflammatory skin reaction appearing on a previously irradiated area following the systemic administration of a reaction-triggering agent. Despite various hypotheses, the pathomechanism of RRD appears complex and is still not fully understood. In addition, no clinical guidelines exist concerning whether drug treatment should be continued upon manifestation of an associated radiation recall phenomenon. We present the case of a patient with docetaxel-induced RRD, which was successfully treated with topical steroids and systemic antihistamines; re-challenge to docetaxel did result in very mild remanifestation of skin reactions.
Strahlenklinik, Sana Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach, Germany. jstrouthos@gmail.com.
Iosif
I
Strouthos
Strahlenklinik, Sana Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach, Germany.
Nikolaos
N
Tselis
Strahlenklinik, Sana Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach, Germany.
Nikolaos
N
Zamboglou
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000150:complications / Q000188:drug therapy / Q000556:secondary; D059248:Chemoradiotherapy / Q000009:adverse effects* / Q000379:methods; D000077143:Docetaxel; D006633:Histamine Antagonists / Q000008:administration & dosage; D006801:Humans; D008297:Male; D011836:Radiation Tolerance / Q000187:drug effects*; D011855:Radiodermatitis / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D043823:Taxoids / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D006633:Histamine Antagonists; D043823:Taxoids; D000077143:Docetaxel
Anti-inflammatory agents, non-steroidal; Antihistaminics; Corticosteriods; Irradiation; Radiation, sensitizing agents