Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy.
A novel type of bio-nanoreactor with catalase loaded inside TaOx hollow nanoshells is fabricated via a mild one-step method. Such bio-nanoreactors could efficiently improve the tumor oxygenation by supplying oxygen via decomposition of endogenic H2 O2 in a tumor microenvironment, and thus synergistically enhance the efficacy of cancer radiotherapy by both depositing radiation energy within the tumor and overcoming hypoxia-induced radiotherapy resistance.
Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
Guosheng
G
Song
Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
Yuyan
Y
Chen
Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
Chao
C
Liang
School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD-X), Medical College of Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
Xuan
X
Yi
Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
Jingjing
J
Liu
Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
Xiaoqi
X
Sun
Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
Sida
S
Shen
School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD-X), Medical College of Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
Kai
K
Yang
Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University, Suzhou, Jiangsu, 215123, P. R. China.
Zhuang
Z
Liu
D000818:Animals; D002374:Catalase / Q000008:administration & dosage* / Q000378:metabolism*; D051379:Mice; D057145:Nanoshells / Q000008:administration & dosage* / Q000737:chemistry*; D009369:Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*; D010100:Oxygen / Q000378:metabolism; D059016:Tumor Microenvironment
D002374:Catalase; D010100:Oxygen
bio-nanoreactors; enzyme delivery; hypoxia; radiotherapy; tantalum oxide