Mutagenic, antimutagenic, antioxidant, anti-lipoxygenase and antimicrobial activities of Scandix pecten-veneris L.
Scandix pecten-veneris L. or Shepherd's-needle is a weed species used in some countries for medicinal purposes. In this study S. pecten-veneris leaves were shade dried, powdered and extracted with methanol. The purpose of this study was to assay the in vitro mutagenic, antimutagenic, antioxidant, antilipoxygenase and antimicrobial activities of S. pecten-veneris leaf extract. The methanolic extract indicated no mutagenicity when tested with Salmonella typhimurium strains TA98 and TA100. Antimutagenic activity was reported with inhibition of mutagenicity in a concentration dependent fashion. The methanolic extract demonstrated antioxidant activity in the DPPH radical-scavenging test (IC50 = 4.57 mg/mL), comparable to ascorbic acid and BHT. Moreover, the extract presented a remarkable and potent inhibition against soybean lipoxygenase (IC50 = 641.57 µg/mL). The methanolic extract was examined for its antimicrobial powers against four different bacteria with MIC values >100. Our results introduced this plant as a useful factor for the treatment of cancer, inflammatory and infectious diseases.
Zabol University of Medical Sciences Zabol Iran.
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Sharifi-Rad
Payame Noor University Department of Biology Tehran Iran.
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Tayeboon
Zabol University of Medical Sciences Department of Pharmacognosy, Faculty of Pharmacy Zabol Iran.
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Miri
University of Zabol Department of Range and Watershed Management, Faculty of Natural Resources Zabol Iran.
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Sharifi-Rad
University of Alabama in Huntsville Department of Chemistry Huntsville USA.
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Setzer
Shahid Beheshti University of Medical Sciences Pediatric Infections Research Center, Mofid Children Hospital Tehran Iran.
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Fallah
Sistan and Baluchestan Department of Plant Protection Higher Educational Complex of Saravan Iran.
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Kuhestani
Persian Gulf University Department of Marine Biotechnology, Faculty of Marine Science and Technology Bushehr Iran.
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Tahanzadeh
Zabol University of Medical Sciences Department of Pharmacognosy, Faculty of Pharmacy Zabol Iran javad.sharifirad@gmail.com.
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Sharifi-Rad
D000890:Anti-Infective Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D016587:Antimutagenic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009153:Mutagens / Q000633:toxicity*; D010936:Plant Extracts / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D016587:Antimutagenic Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D016859:Lipoxygenase Inhibitors; D009153:Mutagens; D010936:Plant Extracts