Visualizing Clonal Evolution in Cancer.
Rapid and inexpensive single-cell sequencing is driving new visualizations of cancer instability and evolution. Krzywinski discusses how to present clone evolution plots in order to visualize temporal, phylogenetic, and spatial aspects of a tumor in a single static image.
Canada's Michael Smith Genome Sciences Centre, BC Cancer Research Center, 100-570 West 7th Ave, Vancouver, BC V5Z 4S6, Canada. Electronic address: martink@bcgsc.ca.
Martin
M
Krzywinski
D000818:Animals; D001296:Audiovisual Aids; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D060965:Clonal Evolution; D003196:Computer Graphics; D019143:Evolution, Molecular; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010641:Phenotype; D010802:Phylogeny; D011157:Population Dynamics; D059010:Single-Cell Analysis / Q000379:methods*; D013997:Time Factors
D014408:Biomarkers, Tumor