Review of the GAS3 Family of Proteins and their Relevance to Cancer.
The GAS3 family of tetraspan proteins has recently been implicated in the progression of cancer. Currently, six members of the GAS3 family have been identified in humans and mice, and while their expressions in disease vary, data suggest that they play a role in epithelial cell structure and function. In this review, we highlight the studies implicating four of the members in disease pathogenesis as well as probe the structural similarities between the family members. Finally, the impact of targeting select members of the family such as PMP22 and EMP2 is discussed.
Department of Ophthalmology, Jules Stein Eye Institute, Los Angeles, CA.
Negin
N
Ashki
Department of Ophthalmology, Jules Stein Eye Institute, Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Lynn
L
Gordon
Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA; Center to Eliminate Cancer Health Disparities, Charles Drew University, Los Angeles, CA.
Madhuri
M
Wadehra
D000818:Animals; D004847:Epithelial Cells / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D051379:Mice; D009185:Myelin Proteins / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000209:etiology / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism
C486403:EMP2 protein, human; C485157:EMP3 protein, human; D008562:Membrane Glycoproteins; D009185:Myelin Proteins; D009363:Neoplasm Proteins; C073687:PMP22 protein, human; C489545:Pmp22 protein, mouse; D011956:Receptors, Cell Surface; C097051:epithelial membrane protein-1