Plant Phenols and Autophagy.
Many plant phenols (stilbenes, curcumins, catechins, flavonoids, etc.) are effective antioxidants and protect cells during oxidative stress. Extensive clinical studies on the potential of phenolic compounds for treatment of cardiovascular, neurodegenerative, oncological, and inflammatory diseases are now being conducted. In addition to direct antioxidant effect, plant phenols may provide a protective effect via activation of the Keap1/Nrf2/ARE redox-sensitive signaling system and regulation of autophagy. In this review, mechanisms of effects of the most common plant phenols on autophagy are presented.
Research Institute of Experimental and Clinical Medicine, Novosibirsk, 630117, Russia. lemen@centercem.ru.
N K
NK
Zenkov
A V
AV
Chechushkov
P M
PM
Kozhin
N V
NV
Kandalintseva
G G
GG
Martinovich
E B
EB
Menshchikova
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism; D001343:Autophagy / Q000187:drug effects*; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010940:Plant Proteins / Q000378:metabolism; D010944:Plants / Q000737:chemistry / Q000378:metabolism*; D000077185:Resveratrol; D015398:Signal Transduction / Q000187:drug effects; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology
D000975:Antioxidants; D010636:Phenols; D010940:Plant Proteins; D013267:Stilbenes; D003474:Curcumin; D000077185:Resveratrol