Adipokines Vaspin and Visfatin in Obese Children.
BACKGROUND
Adipokines provides new insights about the physiology, pathology and treatment of obesity.


OBJECTIVE
We investigated the association between serum vaspin and serum visfatin concentrations with obesity in Egyptian children.


METHODS
Twenty two obese children with body mass index (BMI) above 95th percentile; 11 males and 11 females were included in this study. Their mean age was 9.18 ± 2.8 years. After general clinical examination, fasting blood glucose, triglycerides, total cholesterol and high density lipoprotein cholesterol were measured in cases and controls (n=11). Fasting insulin, vaspin and visfatin were detected using ELIZA. Insulin resistance was estimated by Homeostasis model assessment method (HOMA-IR).


RESULTS
Blood pressure, in both systolic and diastolic measurements was elevated significantly in obese children. Significant elevation of serum insulin and insulin resistance (HOMA/IR) were observed in obese children too. Vaspin and visfatin showed significant elevation in obese children than controls. Significant positive correlations were detected between visfatin and BMI, waist circumference, hip circumference and HOMA/IR. We found that Vaspin and visfatin are higher in obese children.


CONCLUSIONS
Visfatin but not vaspin correlates positively with waist circumference and HOMA/IR in obese children.
National Research Centre, Pediatrics, Cairo, Egypt.
Hassan M
HM
Salama
National Research Centre, Pediatrics, Cairo, Egypt.
Ashraf
A
Galal
National Research Centre, Pediatrics, Cairo, Egypt.
Ayat A
AA
Motawie
National Research Centre, Pediatrics, Cairo, Egypt.
Ashraf F
AF
Kamel
Ain Shams University, Faculty of Science, Cairo, Egypt.
Doaa M
DM
Ibrahim
National Research Centre, Department of Chemical and Clinical Pathology, Cairo, Egypt.
Azza A
AA
Aly
National Research Centre, Pediatrics, Cairo, Egypt.
Emman A
EA
Hassan
Vaspin; adipokines; children; obese; visfatin