Determinants of surgical repair of patent ductus arteriosus in low-birth-weight infants.
OBJECTIVE
To identify risk factors related to the failure of indomethacin therapy and the need for surgical repair in patent ductus arteriosus (PDA) in extremely low-birth-weight (<1000 g) infants (ELBWI).


METHODS
Study subjects were 36 ELBWI with PDA born at a single tertiary perinatal center. They were classified into those who required surgery due to failure of indomethacin treatment (surgical group, n = 21) and those with effective indomethacin treatment (non-surgical group, n = 15). The odds ratios (ORs) and 95% confidence intervals (95% CIs) for the relationship between selected risk factors and surgical treatment of PDA were calculated.


RESULTS
Gestational age of <28 weeks and diameter of PDA of 2 mm or more were independent and significant determinants of the need for surgical repair of PDA (adjusted ORs [95% CIs] = 9.91 [1.16-84.48] and 24.80 [2.72-225.74], respectively). The need for surgical repair of PDA did not correlate with sex, birth weight, 1-min Apgar score, left atrium diameter/aortic diameter (LA/Ao), left ventricular internal dimension at end-diastole, prophylaxes with indomethacin, and total dosage of indomethacin.


CONCLUSIONS
Gestational age at birth of <28 weeks and diameter of PDA of 2 mm or more are determinants of failure of indomethacin treatment for PDA and the need for surgical repair.
Department of Pediatrics, Faculty of Medicine, Fukuoka University, 45-1-7 Nanakuma, Jonan, Fukuoka, 814-0180, Japan. yyoshika@fukuoka-u.ac.jp.
Yukako
Y
Yoshikane
Center for Maternal, Fetal and Neonatal Medicine, Fukuoka University Hospital, Fukuoka, Japan.
Toshiko
T
Mori
Center for Maternal, Fetal and Neonatal Medicine, Fukuoka University Hospital, Fukuoka, Japan.
Toshiyuki
T
Yoshizato
Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Yoshihiro
Y
Miyake
Department of Pediatrics, Faculty of Medicine, Fukuoka University, 45-1-7 Nanakuma, Jonan, Fukuoka, 814-0180, Japan.
Shinichi
S
Hirose
ELBWI; Gestational age; Indomethacin; PDA diameter; PDA ligation