Metabolic syndrome and prostatic disease: potentially role of polyphenols in preventive strategies. A review.
Benign prostatic hyperplasia and prostate cancer are two common urological diseases of the elderly. Scientific community has always looked for a link that could explain the correlation between the two diseases and the role of chronic inflammation in the pathogenesis of BPH and PCa. As shown by the reports of the two diseases relationship with oxidative stress and metabolic syndrome, the use of compounds with antioxidant action could therefore affect both the symptoms and their onset. Polyphenols appear to act not only against oxidative stress but also at different levels. The aim of this review is to evaluate the role of the most important polyphenols on these two urological diseases. As antioxidants these compounds seems to have a direct action on the cell cycle and hormone function, important for both prostate cancer and BPH. Despite a large number of articles about the relationship of the polyphenols with prostate cancer, very little evidence exists for BPH. Additional clinical trials or meta-analysis are necessary on this topic.
Dipartimento di Urologia, Facoltà di Medicina Policlinico, Università di Catania, Italia.
Tommaso
T
Castelli
Dipartimento di Urologia, Facoltà di Medicina Policlinico, Università di Catania, Italia.
Giorgio Ivan
GI
Russo
Dipartimento di Urologia, Facoltà di Medicina Policlinico, Università di Catania, Italia.
Giulio
G
Reale
Dipartimento di Urologia, Facoltà di Medicina Policlinico, Università di Catania, Italia.
Salvatore
S
Privitera
Dipartimento di Urologia, Facoltà di Medicina Policlinico, Università di Catania, Italia.
Mario
M
Chisari
Dipartimento di Urologia, Facoltà di Medicina Policlinico, Università di Catania, Italia.
Eugenia
E
Fragalà
Dipartimento di Urologia, Facoltà di Medicina Policlinico, Università di Catania, Italia.
Vincenzo
V
Favilla
Dipartimento di Urologia, Facoltà di Medicina Policlinico, Università di Catania, Italia.
Sebastiano
S
Cimino
Dipartimento di Urologia, Facoltà di Medicina Policlinico, Università di Catania, Italia.
Giuseppe
G
Morgia
D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000517:prevention & control*; D018384:Oxidative Stress / Q000187:drug effects; D059808:Polyphenols / Q000627:therapeutic use*; D011470:Prostatic Hyperplasia / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D016896:Treatment Outcome
D000975:Antioxidants; D059808:Polyphenols