An investigation of effects of modification processes on physical properties and mechanism of drug release for sustaining drug release from modified rice.
The aim of this study was to investigate the effect of modification processes on physical properties and explain the mechanism of sustained drug release from modified rice (MR). Various types of Vietnamese rice were introduced in the study as the matrices of sustained release dosage form. Rice was thermally modified in water for a determined temperature at different times with a simple process. Then tablets containing MR and isradipine, the model drug, were prepared to investigate the capability of sustained drug release. Scanning electron microscopy (SEM) was used to determine different morphologies between MR formulations. Flow property of MR was analyzed by Hausner ratio and Carr's indices. The dissolution rate and swelling/erosion behaviors of tablets were evaluated at pH 1.2 and pH6.8 at 37±0.5°C. The matrix tablet containing MR showed a sustained release as compared to the control. The SEM analyses and swelling/erosion studies indicated that the morphology as well as swelling/erosion rate of MR were modulated by modification time, drying method and incubation. It was found that the modification process was crucial because it could highly affect the granule morphologies and hence, leading to the change of flowability and swelling/erosion capacity for sustained release of drug.
Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University, Ho Chi Minh City, Viet Nam.
Vuong Duy
VD
Ngo
Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University, Ho Chi Minh City, Viet Nam.
Thinh Duc
TD
Luu
Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University, Ho Chi Minh City, Viet Nam.
Toi
T
Van Vo
Faculty of Pharmacy, University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam.
Van-Thanh
VT
Tran
School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria, Australia.
Wei
W
Duan
School of Medicine, Deakin University, Pigdons Road, Waurn Ponds, Victoria, Australia. Electronic address: phuong.tran1@deakin.edu.au.
Phuong Ha-Lien
PH
Tran
Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University, Ho Chi Minh City, Viet Nam. Electronic address: ttdthao@hcmiu.edu.vn.
Thao Truong-Dinh
TT
Tran
D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D012275:Oryza / Q000737:chemistry*
D003692:Delayed-Action Preparations
Flow property; Incubation; Modified rice; Morphology; Sustained release