Bone Density, Osteocalcin and Deoxypyridinoline for Early Detection of Osteoporosis in Obese Children.
OBJECTIVE
This study aimed at comparing between bone density using DEXA, serum osteocalcin and urinary DPD in obese and non obese prepubertal children.


METHODS
After taking the consent of eighty children they were subjected to: full examination, anthropometric measurements, blood samples were withdrawn to determine serum osteocalcin, Ca, Ph, alkaline phosphatase, and urinary DPD. Bone densities, body composition of the whole body were examined using DEXA. Data were analyzed using SPSS.


RESULTS
All anthropometric variables showed significant increase in obese children except for height in comparison to control group. Total mass, lean + BMC, lean, fat, area, BMC, BMD and Z score of the whole body were significantly increased in obese children. Serum calcium showed significant increase while alkaline phosphatase was significantly decreased in obese children. DPD showed no significant difference between obese and non obese children. Significant negative correlation was found between ca, lean, lean + BMC and total mass. Serum alkaline phosphatase showed also a significant negative correlation with (lean + BMC and total mass). Serum osteocalcin showed negative significant correlation with area, BMC, BMD, lean and Z score.


CONCLUSIONS
Obese children showed significant increase in anthropometric and DEXA parameters, increase in serum calcium and significant decrease in serum alkaline phosphatase. Osteocalcin was negatively correlated with most of DEXA results.
Institute of Postgraduate Childhood Studies, Ain Shams University, Medical Studies Department, Cairo, Egypt.
Ghada
G
El-Dorry
National Research Center, Child Health Department, Cairo, Egypt.
Hala
H
Ashry
National Research Center, Child Health Department, Cairo, Egypt.
Tarek
T
Ibrahim
National Research Center, Medical Biochemistry Department, Cairo, Egypt.
Tahany
T
Elias
National Research Center, Child Health Department, Cairo, Egypt.
Fatma
F
Alzaree
DEXA parameters; alkaline phosphatise; calcium; obese Egyptian children; osteocalcin; phosphorus