Autoimmune pancreatitis and inflammatory bowel disease: Case series and review of the literature.
BACKGROUND
An association between autoimmune pancreatitis (AIP) and inflammatory bowel disease (IBD) has been documented, but its clinical significance remains unclear.


OBJECTIVE
Characterize the particular phenotypes of IBD and AIP in patients with both diseases (IBD-AIP).


METHODS
Retrospective study of patients with IBD-AIP followed at our IBD referral centre and literature search to identify previous reports of IBD-AIP patients.


RESULTS
We found 5 cases of IBD-AIP in our records and 5 prior studies reporting 47 additional IBD-AIP patients. A combined analysis showed that most IBD-AIP patients were young males with ulcerative colitis, usually extensive, and that in all Crohn's disease cases, the colon was involved. IBD severity was heterogeneous across studies, ranging from mild disease to severe disease requiring colectomy. The most frequent type of AIP was idiopathic duct-centric pancreatitis (type 2) and it most often occurred after the diagnosis of IBD. AIP presentation and treatment were similar to those in the general population.


CONCLUSIONS
AIP occurs rarely with IBD; in the other way around, up to 1/3 of AIP patients, especially type 2, may have concomitant IBD. IBD-AIP patients are usually males presenting extensive colitis. More data are needed on the impact of AIP, if any, in IBD course.
Gastroenterology Department, Hospital Garcia de Orta, Almada, Portugal.
Lídia
L
Roque Ramos
Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Christopher J
CJ
DiMaio
Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
David B
DB
Sachar
Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Ashish
A
Atreja
Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Jean-Frédéric
JF
Colombel
Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: joana.torres@mssm.edu.
Joana
J
Torres
D000293:Adolescent; D000328:Adult; D001327:Autoimmune Diseases / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009518:New York; D010195:Pancreatitis / Q000175:diagnosis*; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D055815:Young Adult
Autoimmune pancreatitis; Idiopathic duct-centric pancreatitis; Inflammatory bowel disease; Lymphoplasmacytic sclerosing pancreatitis