Peptic Ulcer Disease and Helicobacter pylori Infection in Different Siberian Ethnicities.
BACKGROUND
The high prevalence of Helicobacter pylori (H. pylori) infection in eastern Siberia is consistently established. In the same geographic area, however, fragmentary information is available on the epidemiology of the peptic ulcer disease (PUD).


OBJECTIVE
To assess the prevalence of H. pylori infection (including CagA status) and PUD in different eastern Siberian ethnicities.


METHODS
An endoscopy population of 3149 eastern Siberian dyspeptic patients was considered [1727 Europoids and 1422 Mongoloids (Evenks = 792; Khakases = 630)]. H. pylori status was assessed by urease test and/or serum anti-H. pylori IgG and/or histology. CagA status was serologically assessed (anti-CagA antibodies).


RESULTS
All the Siberian ethnicities featured high rates of H. pylori infection (Europoids = 87.1%, Evenks = 88.6%, Khakases = 85.4%). Among the 1504 H. pylori-positive Europoids, the prevalence of CagA-positive status (68.7%) was significantly higher than that featured by the 1240 H. pylori-positive Mongoloid ethnicities (46.9%; p < .001 for both comparisons). Peptic ulcer disease significantly prevailed among Europoids (prevalence among Europoid Evenks and Khakases: 8.9% and 8.3%, respectively; prevalence among Mongoloid Evenks and Khakases = 1.0% and 4.4%, respectively).


CONCLUSIONS
eastern Siberian populations feature consistent high rates of H. pylori infection, but different prevalence of peptic ulcer disease. In particular, Europoids featured a prevalence of both CagA-positive status and peptic ulcer disease significantly higher than that of the Mongoloid ethnicities. These results suggest that both environmental factors (coexisting with the H. pylori infection) and host-related variables modulate the clinicopathological expression of the H. pylori -associated gastric diseases.
Gastroenterology Department, Federal State Budgetary Scientific Institution "Scientific research institute of medical problems of the North", Krasnoyarsk, Russia.
Vladislav V
VV
Tsukanov
Gastroenterology Department, Federal State Budgetary Scientific Institution "Scientific research institute of medical problems of the North", Krasnoyarsk, Russia.
Edward V
EV
Kasparov
Gastroenterology Department, Federal State Budgetary Scientific Institution "Scientific research institute of medical problems of the North", Krasnoyarsk, Russia.
Julia L
JL
Tonkikh
Department of Internal Medicine, Khakass State University, Abakan, Russia.
Olga V
OV
Shtygasheva
Department of Internal Medicine, Khakass State University, Abakan, Russia.|Endoscopy Department, Khakass Republican Hospital, Abakan, Russia.
Nikolay N
NN
Butorin
Gastroenterology Department, Federal State Budgetary Scientific Institution "Scientific research institute of medical problems of the North", Krasnoyarsk, Russia.
Olga S
OS
Amelchugova
Gastroenterology Department, Federal State Budgetary Scientific Institution "Scientific research institute of medical problems of the North", Krasnoyarsk, Russia.
Alexander V
AV
Vasyutin
Gastroenterology Department, Federal State Budgetary Scientific Institution "Scientific research institute of medical problems of the North", Krasnoyarsk, Russia.
Elena P
EP
Bronnikova
Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy.
Matteo
M
Fassan
Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy.|Veneto Cancer Registry, Padua, Italy.
Massimo
M
Rugge
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000032:analysis; D001426:Bacterial Proteins / Q000032:analysis; D001944:Breath Tests; D003955:Diagnostic Tests, Routine; D005006:Ethnicity; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology*; D006801:Humans; D007118:Immunoassay; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000453:epidemiology*; D015995:Prevalence; D012800:Siberia / Q000453:epidemiology; D055815:Young Adult
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007074:Immunoglobulin G; C080866:cagA protein, Helicobacter pylori

Helicobacter pylori
; CagA; peptic ulcer disease; subpolar epidemiology