Orofacial antinociceptive effect of the ethanolic extract of Annona vepretorum Mart. (Annonaceae).
Annona vepretorum Mart. (Annonaceae) is a species popularly known in Brazil as "araticum" and "pinha da Caatinga". We have evaluated the antinociceptive effects of A. vepretorum in formalin-, capsaicin-, and glutamate-induced orofacial nociception in mice. Male Swiss mice were pretreated with either saline (p.o.), A. vepretorum ethanol extract (Av-EtOH 25, 50 and 100 mg/kg, p.o.), or morphine (10 mg/kg, i.p.), before formalin, capsaicin, or glutamate was injected into the right upper lip. Pre-treatment with Av-EtOH at all doses produced a reduction in face-rubbing behavior induced by formalin in both phases, and these pre-treatments also produced a significant antinociceptive effect in the capsaicin and glutamate tests. Pre-treatment with naloxone (1.5 mg/kg, i.p.) did not reverse the antinociceptive activity of the extract at the dose of 100 mg/kg in the first phase of this test. Our results suggest that Av-EtOH might be useful in the treatment of orofacial pain.
Juliane C
JC
Silva
Larissa A R O
LA
Macedo
Grasielly R
GR
Souza
Raimundo G
RG
Oliveira-Junior
Sarah R G
SR
Lima-Saraiva
Érica M
ÉM
Lavor
Mariana G
MG
Silva
Marilia T S
MT
Souza
Leonardo R
LR
Bonjardim
Lucindo J
LJ
Quintans-Júnior
Rosemairy L
RL
Mendes
Jackson R G S
JR
Almeida
D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D031041:Annona / Q000737:chemistry*; D002211:Capsaicin; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D000431:Ethanol / Q000737:chemistry; D005157:Facial Pain / Q000139:chemically induced / Q000517:prevention & control*; D005557:Formaldehyde; D018698:Glutamic Acid; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010147:Pain Measurement / Q000379:methods; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*
D000700:Analgesics; D009292:Narcotic Antagonists; D010936:Plant Extracts; D005557:Formaldehyde; D009270:Naloxone; D000431:Ethanol; D018698:Glutamic Acid; D002211:Capsaicin