The pharmacometrician's dilemma: the tension between mechanistic and empirical approaches in mathematical modelling and simulation - a continuation of the age-old dispute between rationalism and empiricism?
Department of Pharmaceutical Sciences, Center for Data Enabled Science and Engineering State University of New York University at Buffalo, Roswell Park Cancer Institute, Buffalo.
Robert
R
Bies
Department of Pharmaceutical Sciences, State University of New York University at Buffalo, Buffalo, USA.
Sarah
S
Cook
Otago Pharmacometrics Group, School of Phamacy, University of Otago, Dunedin, New Zealand.
Stephen
S
Duffull
D003198:Computer Simulation; D019348:Empiricism; D008962:Models, Theoretical; D010601:Pharmacology, Clinical; D010684:Philosophy