Mitochondria as a Signaling Hub and Target for Phenoptosis Shutdown.
Mitochondria have long been studied as the main energy source and one of the most important generators of reactive oxygen species in the eukaryotic cell. Yet, new data suggest mitochondria serve as a powerful cellular regulator, pathway trigger, and signal hub. Some of these crucial mitochondrial functions appear to be associated with RNP-granules. Deep and versatile involvement of mitochondria in general cellular regulation may be the legacy of parasitic behavior of the ancestors of mitochondria in the host cells. In this regard, we also discuss here the perspectives of using mitochondria-targeted compounds for systemic correction of phenoptotic shifts.
Southern Federal University, Academy of Biology and Biotechnology, Rostov-on-Don, 344090, Russia. vladimirchi@sfedu.ru.
P V
PV
Zolotukhin
A A
AA
Belanova
E V
EV
Prazdnova
M S
MS
Mazanko
M M
MM
Batiushin
V K
VK
Chmyhalo
V A
VA
Chistyakov
D017209:Apoptosis; D003594:Cytoplasmic Granules / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D017382:Reactive Oxygen Species; D012261:Ribonucleoproteins / Q000378:metabolism; D015398:Signal Transduction
D024101:Mitochondrial Proteins; D017382:Reactive Oxygen Species; D012261:Ribonucleoproteins