A Wireless Pressure Sensor Integrated with a Biodegradable Polymer Stent for Biomedical Applications.
This paper describes the fabrication and characterization of a wireless pressure sensor for smart stent applications. The micromachined pressure sensor has an area of 3.13 × 3.16 mm² and is fabricated with a photosensitive SU-8 polymer. The wireless pressure sensor comprises a resonant circuit and can be used without the use of an internal power source. The capacitance variations caused by changes in the intravascular pressure shift the resonance frequency of the sensor. This change can be detected using an external antenna, thus enabling the measurement of the pressure changes inside a tube with a simple external circuit. The wireless pressure sensor is capable of measuring pressure from 0 mmHg to 230 mmHg, with a sensitivity of 0.043 MHz/mmHg. The biocompatibility of the pressure sensor was evaluated using cardiac cells isolated from neonatal rat ventricular myocytes. After inserting a metal stent integrated with the pressure sensor into a cardiovascular vessel of an animal, medical systems such as X-ray were employed to consistently monitor the condition of the blood vessel. No abnormality was found in the animal blood vessel for approximately one month. Furthermore, a biodegradable polymer (polycaprolactone) stent was fabricated with a 3D printer. The polymer stent exhibits better sensitivity degradation of the pressure sensor compared to the metal stent.
MEMS and Nanotechnology Laboratory, Mechanical Engineering, Chonnam National University, Gwangju 61186, Korea. atoz153@gmail.com.
Jongsung
J
Park
Department of Defense Science and Technology, Gwangju University, Gwangju 61743, Korea. jkkim79@gwangju.ac.kr.
Ji-Kwan
JK
Kim
MEMS and Nanotechnology Laboratory, Mechanical Engineering, Chonnam National University, Gwangju 61186, Korea. swatipatil39@gmail.com.
Swati J
SJ
Patil
CGBio Co. Ltd., Jangseong-gun 57248, Korea. pjk23@naver.com.
Jun-Kyu
JK
Park
Department of Nature-Inspired Nanoconvergence Systems, Nanoconvergence Mechanical System Division, Korea Institute of Machinery and Materials (KIMM), Daejeon 34103, Korea. psa@kimm.re.kr.
SuA
S
Park
MEMS and Nanotechnology Laboratory, Mechanical Engineering, Chonnam National University, Gwangju 61186, Korea. mems@jnu.ac.kr.
Dong-Weon
DW
Lee
D020341:Absorbable Implants; D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D011108:Polymers / Q000737:chemistry; D051381:Rats; D015607:Stents; D014690:Venous Pressure / Q000502:physiology; D059015:Wireless Technology / Q000295:instrumentation*
D011108:Polymers
LC circuit; SU-8; polymer stent; pressure sensor; wireless sensing