Studying the Effect of a Composition of the Cluster Core in High-Radiopacity Cluster Complexes of Rhenium on Their Acute Toxicity In Vivo.
An in vivo study was performed to evaluate the dependence of acute toxicity of high-radiopacity and luminescent octahedral cluster complexes of rhenium after intravenous injection on a composition of the cluster core. Changes in mouse body weight, water and food consumption, degree of intoxication, and morphological changes in the visceral organs were studied after intravenous injection of the following cluster complexes with various internal ligands (S, Se, or Te): Na4[{Re 6 Te 8 }(CN)6], Na4[{Re 6 Se 8 }(CN)6], and Na4[{Re 6 S 8 }(CN)6]. The Na4[{Re 6 S 8 } (CN)6] cluster complex was shown to be the safest for animals.
Novosibirsk State University, Novosibirsk, Russia.|Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
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Pozmogova
Novosibirsk State University, Novosibirsk, Russia.|Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.|Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
A A
AA
Krasil'nikova
Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.|Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
A A
AA
Ivanov
Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia. shestopalov2@ngs.ru.|Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia. shestopalov2@ngs.ru.|A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. shestopalov2@ngs.ru.
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Shestopalov
Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
S N
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Gyrylova
Novosibirsk State University, Novosibirsk, Russia.
L V
LV
Shestopalova
Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
A M
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Shestopaloiv
Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
V A
VA
Shkurupy
D000818:Animals; D056831:Coordination Complexes / Q000737:chemistry* / Q000633:toxicity*; D005260:Female; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D012211:Rhenium / Q000737:chemistry* / Q000633:toxicity*
D056831:Coordination Complexes; D012211:Rhenium
octahedral cluster complexes of rhenium; toxicity