Inference of Ancestry in Forensic Analysis II: Analysis of Genetic Data.
Three approaches applicable to the analysis of forensic ancestry-informative marker data-STRUCTURE, principal component analysis, and the Snipper Bayesian classification system-are reviewed. Detailed step-by-step guidance is provided for adjusting parameter settings in STRUCTURE with particular regard to their effect when differentiating populations. Several enhancements to the Snipper online forensic classification portal are described, highlighting the added functionality they bring to particular aspects of ancestry-informative SNP analysis in a forensic context.
Forensic Genetics Unit, Luis Concheiro Institute of Forensic Sciences, Genomic Medicine Group, University of Santiago de Compostela, Galicia, 15782, Spain. carla.arcanjo.santos@gmail.com.
Carla
C
Santos
Forensic Genetics Unit, Luis Concheiro Institute of Forensic Sciences, Genomic Medicine Group, University of Santiago de Compostela, Galicia, 15782, Spain.
Chris
C
Phillips
Faculty of Mathematics, University of Santiago de Compostela, Galicia, Spain.
A
A
Gomez-Tato
Faculty of Mathematics, University of Santiago de Compostela, Galicia, Spain.
J
J
Alvarez-Dios
Forensic Genetics Unit, Luis Concheiro Institute of Forensic Sciences, Genomic Medicine Group, University of Santiago de Compostela, Galicia, 15782, Spain.|Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
Ángel
Á
Carracedo
Forensic Genetics Unit, Luis Concheiro Institute of Forensic Sciences, Genomic Medicine Group, University of Santiago de Compostela, Galicia, 15782, Spain.
Maria Victoria
MV
Lareu
D053803:Forensic Genetics / Q000379:methods*; D005828:Genetics, Population; D006801:Humans; D020407:Internet; D020641:Polymorphism, Single Nucleotide; D012984:Software
Bayesian methods; Genetic ancestry; PCA; Reference data; SPSmart browser; STRUCTURE; Snipper