The association of PTPN22 (rs2476601) and IL2RA (rs11594656) polymorphisms with T1D in Egyptian children.
BACKGROUND
Type 1 diabetes mellitus (T1D) is a T cell-mediated autoimmune disease characterized by the destruction of pancreatic β cells. PTPN22 and IL2RA polymorphisms have been found to be associated with several autoimmune diseases including T1D.


OBJECTIVE
We aimed to elucidate the role of PTPN22 and IL2RA polymorphisms in predisposition of T1D in Egyptian children.


METHODS
We studied 150 children and adolescents with T1D and 165 healthy controls. The PTPN22 (rs2476601) and IL2RA (rs11594656) polymorphisms were genotyped using polymerase chain reaction.


RESULTS
We found that carriers of the T allele of PTPN22 were significantly more likely to develop T1D (OR=2.2, 95% CI=1.2-4, P=0.01). Also, the carrier of TT genotype and T allele of IL2RA more likely to develop T1D (OR=2.8, 1.4, respectively, P=0.03). There was a statistically significant association between T allele of PTPN22 gene and females ⩽10years old at the onset of diabetes (OR=4, 95% CI=1.2-13.4, P=0.019).


CONCLUSIONS
This study suggests a possible association between the T allele of PTPN22 gene and TT genotype of IL2RA with T1D in studied Egyptian children, especially, females with early onset diabetes who carried the 1858T allele.
Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Hadeel M
HM
Abdelrahman
Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Laila M
LM
Sherief
Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Doaa M
DM
Abd Elrahman
Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ashgan
A
Alghobashy
Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Hosam F
HF
Elsaadani
Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. Electronic address: randahussiny@yahoo.com.
Randa H
RH
Mohamed
D000293:Adolescent; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D004534:Egypt; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics*; D012737:Sex Factors
C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22
IL2RA; PTPN22; Polymorphism; T1D