The KAT's Out of the Bag: Histone Acetylation Promotes Centromere Assembly.
Heterochromatin is incompatible with centromeric chromatin assembly and propagation. In this issue of Developmental Cell, Ohzeki et al. (2016) reveal that a critical role of the Mis18 complex is to transiently recruit the lysine acetyltransferase KAT7 to centromeres to facilitate the removal of H3K9me3 and the deposition of CENP-A.
Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06268, USA.
Jason
J
Palladino
Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06268, USA; Institute for Systems Genomics, University of Connecticut, Storrs, CT 06268, USA. Electronic address: barbara.mellone@uconn.edu.
Barbara G
BG
Mellone
D000107:Acetylation; D002503:Centromere / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D006367:HeLa Cells; D006657:Histones / Q000378:metabolism*; D006801:Humans; D000070837:Lysine Acetyltransferases / Q000378:metabolism*; D008954:Models, Biological
D002843:Chromatin; D006657:Histones; D000070837:Lysine Acetyltransferases