Mitochondrial dysfunction and oxidative stress in aging and cancer.
Aging and cancer are the most important issues to research. The population in the world is growing older, and the incidence of cancer increases with age. There is no doubt about the linkage between aging and cancer. However, the molecular mechanisms underlying this association are still unknown. Several lines of evidence suggest that the oxidative stress as a cause and/or consequence of the mitochondrial dysfunction is one of the main drivers of these processes. Increasing ROS levels and products of the oxidative stress, which occur in aging and age-related disorders, were also found in cancer. This review focuses on the similarities between ageing-associated and cancer-associated oxidative stress and mitochondrial dysfunction as their common phenotype.
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.|National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.
Anna V
AV
Kudryavtseva
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
George S
GS
Krasnov
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Alexey A
AA
Dmitriev
National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.
Boris Y
BY
Alekseev
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Olga L
OL
Kardymon
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.|National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.
Asiya F
AF
Sadritdinova
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Maria S
MS
Fedorova
A.V. Vishnevsky Institute of Surgery, Moscow, Russia.
Anatoly V
AV
Pokrovsky
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Nataliya V
NV
Melnikova
National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, Russia.
Andrey D
AD
Kaprin
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.|Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
Alexey A
AA
Moskalev
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Anastasiya V
AV
Snezhkina
D000375:Aging / Q000473:pathology*; D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000473:pathology*; D009369:Neoplasms / Q000209:etiology / Q000473:pathology*; D018384:Oxidative Stress / Q000502:physiology*
Gerotarget; ROS; aging; cancer; mitochondrial dysfunction; oxidative stress