Incidence of venous thromboembolism in patients with diffuse large B-cell lymphoma.
Venous thromboembolism (VTE) in patients with diffuse large B-cell lymphoma (DLBCL) is an important complication. We aimed to asses the risk of VTE and the quality of VTE discharge diagnosis in a cohort of DLBCL patients. Objective confirmed VTE events during two years of follow-up were identified by the review of medical records of consecutive patients with DLBCL at Aalborg University Hospital from 2007 until 2013. Information on baseline disease stage, lifestyle factors, and anticoagulant therapy were registered. Cox regression was used to assess VTE risk factors. The data quality on VTE discharge diagnosis was evaluated by comparing data on VTE discharge diagnosis from the Danish National Registry of Patients with information from the medical records. Eleven percent of patients were diagnosed with VTE. Prior VTE, performance status, and Ann Arbor stage were associated with VTE. The positive predictive value of a VTE discharge diagnosis was 85% and the sensitivity 53%.
a Department of Hematology , Aalborg University Hospital , Aalborg , Denmark.
Ina Hornemann
IH
Borg
a Department of Hematology , Aalborg University Hospital , Aalborg , Denmark.|b Unit of Clinical Biostatistics and Bioinformatics , Aalborg University Hospital , Aalborg , Denmark.
Mette Dahl
MD
Bendtsen
a Department of Hematology , Aalborg University Hospital , Aalborg , Denmark.|c Department of Clinical Medicine , Aalborg University , Denmark.
Martin
M
Bøgsted
a Department of Hematology , Aalborg University Hospital , Aalborg , Denmark.|c Department of Clinical Medicine , Aalborg University , Denmark.
Jakob
J
Madsen
a Department of Hematology , Aalborg University Hospital , Aalborg , Denmark.|c Department of Clinical Medicine , Aalborg University , Denmark.
Marianne Tang
MT
Severinsen
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D063868:Patient Outcome Assessment; D016016:Proportional Hazards Models; D012042:Registries; D012307:Risk Factors; D047368:Tumor Burden; D054556:Venous Thromboembolism / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology*; D055815:Young Adult
Cancer; discharge diagnosis; lymphoma; risk factors; venous thromboembolism