Tackling Drug-Resistant Tuberculosis: Current Trends and Approaches.
Tuberculosis is very much rampant in our society and accounts for a large number of deaths annually. In spite of consistent efforts being made, the disease has not been curtailed yet. The emergence of MDR and XDR strains in the society along with an increase in the number of HIV cases and that of latent TB, have further aggravated the problem making the disease very much persistent. The current situation clearly manifests the need to discover and develop new potent molecules/approaches that could help to tackle drug resistance. Various molecules, such as derivatives of fluoroquinolones (e.g. gatifloxacin, moxifloxacin and DC-159a), rifamycins (rifapentine), oxazolidinones (linezolid, sutezolid/PNU-100480), diarylquinolines (TMC207/bedaquiline), antifungal azoles, pyrrole (LL3858), nitroimidazopyran (PA824), nitroimidazole (OPC67683, TBA-354), diamine (SQ109) and benzothiazinone (BTZ043) are being developed in an attempt to combat the disease. This review presents a general introduction to the current status of the disease, the biology of the pathogen as well as the state of drug development against tuberculosis (TB) with emphasis on the major problems and bottlenecks associated with the same. Starting from the first drug against TB, the review discusses the entire history and the course of development of the drugs which are available today in the market as well as those which are under various phases of clinical and pre-clinical trials along with their mechanism of action. It also talks about the possible role of nanosciences in combating TB.
Rashmi
R
Tandon
Department of Chemistry, University of Delhi, Delhi-110 007, India.
Mahendra
M
Nath
D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D052160:Benzothiazoles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002473:Cell Wall / Q000187:drug effects / Q000378:metabolism; D002986:Clinical Trials as Topic; D005029:Ethylenediamines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000378:metabolism; D009593:Nitroimidazoles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D015363:Quinolones / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012294:Rifamycins / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
D000995:Antitubercular Agents; D052160:Benzothiazoles; D005029:Ethylenediamines; D009593:Nitroimidazoles; D015363:Quinolones; D012294:Rifamycins
Bactericidal; Mycobacterium tuberculosis; bedaquiline; diarylquinolines; ethylenediamine; nitroimidazoles; oxazolidinones; rifamycin