Low serotonin1B receptor binding potential in the anterior cingulate cortex in drug-free patients with recurrent major depressive disorder.
The pathophysiology of major depressive disorder (MDD) is not fully understood and the diagnosis is largely based on history and clinical examination. So far, several lines of preclinical data and a single imaging study implicate a role for the serotonin1B (5-HT1B) receptor subtype. We sought to study 5-HT1B receptor binding in brain regions of reported relevance in patients with MDD. Subjects were examined at the Karolinska Institutet PET centre using positron emission tomography (PET) and the 5-HT1B receptor selective radioligand [(11)C]AZ10419369. Ten drug-free patients with recurrent MDD and ten control subjects matched for age and sex were examined. The main outcome measure was [(11)C]AZ10419369 binding in brain regions of reported relevance in the pathophysiology of MDD. The [(11)C]AZ10419369 binding potential was significantly lower in the MDD group compared with the healthy control group in the anterior cingulate cortex (20% between-group difference), the subgenual prefrontal cortex (17% between-group difference), and in the hippocampus (32% between-group difference). The low anterior cingulate [(11)C]AZ10419369 binding potential in patients with recurrent MDD positions 5-HT1B receptor binding in this region as a putative biomarker for MDD and corroborate a role of the anterior cingulate cortex and associated areas in the pathophysiology of recurrent MDD.
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, R5:0, Karolinska Universitetssjukhuset i Solna, 171 76 Stockholm, Sweden. Electronic address: mikael.tiger@ki.se.
Mikael
M
Tiger
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, R5:0, Karolinska Universitetssjukhuset i Solna, 171 76 Stockholm, Sweden; AstraZeneca, Translational Science Center, Karolinska Institutet, 171 76 Stockholm, Sweden.
Lars
L
Farde
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, R5:0, Karolinska Universitetssjukhuset i Solna, 171 76 Stockholm, Sweden.
Christian
C
Rück
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, R5:0, Karolinska Universitetssjukhuset i Solna, 171 76 Stockholm, Sweden.
Andrea
A
Varrone
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, R5:0, Karolinska Universitetssjukhuset i Solna, 171 76 Stockholm, Sweden.
Anton
A
Forsberg
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, R5:0, Karolinska Universitetssjukhuset i Solna, 171 76 Stockholm, Sweden.
Nils
N
Lindefors
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, R5:0, Karolinska Universitetssjukhuset i Solna, 171 76 Stockholm, Sweden.
Christer
C
Halldin
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, R5:0, Karolinska Universitetssjukhuset i Solna, 171 76 Stockholm, Sweden.
Johan
J
Lundberg
D000328:Adult; D000368:Aged; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000378:metabolism*; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000378:metabolism; D044302:Receptor, Serotonin, 5-HT1B / Q000378:metabolism*; D012008:Recurrence; D055815:Young Adult
D044302:Receptor, Serotonin, 5-HT1B
Biomarker; Limbic system; PET; [(11)C]AZ10419369