Integracides H-J: New tetracyclic triterpenoids from the endophytic fungus Fusarium sp.
Three new tetracyclic triterpenoids namely, integracides H (1), I (4), and J (5), along with integracides B (3) and F (2) have been isolated from the endophytic fungus Fusarium sp. isolated from the roots of Mentha longifolia L. (Labiatae) growing in Saudi Arabia. The structure elucidation of the isolated compounds was achieved by spectroscopic analysis including UV, IR, 1D ((1)H and (13)C) and 2D ((1)H(1)H COSY, TOCSY, HSQC, HMBC, and NOESY) NMR as well as HRESIMS and comparison with literature data. Integracides H (1) and J (5) showed significant anti-leishmanial activity towards Leishmania donovani with IC50 values of 4.75 and 3.29μM, respectively compared to pentamidine (IC50 6.35μM). Moreover, they displayed potent cytotoxic activity towards BT-549, SKOV-3, and KB cell lines with IC50 values of 1.82, 1.32, and 0.18μM and 2.46, 3.01, and 2.54μM, respectively.
Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah, Al Munawwarah 30078, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: sabrinshaur@gmail.com.
Sabrin R M
SR
Ibrahim
Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Hossam M
HM
Abdallah
Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Gamal A
GA
Mohamed
National Center for Natural Products Research, Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, MS 38677, USA.
Samir A
SA
Ross
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D005670:Fusarium / Q000737:chemistry*; D006801:Humans; D007893:Leishmania donovani / Q000187:drug effects*; D027541:Mentha / Q000382:microbiology; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
D000972:Antineoplastic Agents, Phytogenic; D000981:Antiprotozoal Agents; D014315:Triterpenes; C481036:integracide B; C000614041:integracide H; C000614042:integracide I; C000614043:integracide J
Anti-leishmanial; Cytotoxic; Fusarium sp.; Integracides; Triterpenoids