Novel concept on antiviral strategies to dengue.
Recent evidence has revealed that asymptomatic and/or persistent dengue virus (DENV) infections play a role in the cycling pattern of dengue outbreaks. These findings add a new dimension to the continually evolving search for effective prevention strategies in dengue. Disappointing outcomes of clinical trials in anti-dengue modalities have become commonplace. These failures may result from confounding variables and/or unresolved scientific issues that surround dengue, including the replication cycle of DENV in a natural setting, the target cells and reservoir for viral replication in vivo, and the effect of asymptomatic/persistent carriers in the dissemination of dengue. This article sets forth to address these issues using the most updated information available in the literature and to propose a novel antiviral strategy for the prevention and control of dengue.
Department of Biotechnology and Bioindustry Science, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.
Yu-Chih
YC
Lo
Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: gperng@mail.ncku.edu.tw.
Guey Chuen
GC
Perng
D000330:Aedes / Q000821:virology; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D058345:Asymptomatic Infections; D002353:Carrier State / Q000821:virology; D003715:Dengue / Q000188:drug therapy* / Q000517:prevention & control* / Q000821:virology; D003716:Dengue Virus / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D014766:Viremia; D014771:Virion / Q000737:chemistry / Q000187:drug effects; D014779:Virus Replication
D000998:Antiviral Agents