Metal-Free Oxidative 1,2-Arylmethylation Cascades of N-(Arylsulfonyl)acrylamides Using Peroxides as the Methyl Resource.
A new, metal-free oxidative 1,2-arylmethylation cascades of N-(arylsulfonyl)acrylamides for the assembly of 2,2-disubstituted-N-arylbutanamides containing an all-carbon quaternary center is presented. This reaction enables the one-step formation of two new C-C bonds through a sequence of methylation/1,4-aryl migration/desulfonylation using an organic peroxide as the methyl resource with a broad substrate scope and excellent functional group tolerance.
State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha 410082, China.
Fang-Lin
FL
Tan
Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University , Nanchang 330063, China.
Ren-Jie
RJ
Song
State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha 410082, China.
Ming
M
Hu
State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University , Changsha 410082, China.|Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University , Nanchang 330063, China.
Jin-Heng
JH
Li