The food processing contaminant glyoxal promotes tumour growth in the multiple intestinal neoplasia (Min) mouse model.
Glyoxal is formed endogenously and at a higher rate in the case of hyperglycemia. Glyoxal is also a food processing contaminant and has been shown to be mutagenic and genotoxic in vitro. The tumourigenic potential of glyoxal was investigated using the multiple intestinal neoplasia (Min) mouse model, which spontaneously develops intestinal tumours and is susceptible to intestinal carcinogens. C57BL/6J females were mated with Min males. Four days after mating and throughout gestation and lactation, the pregnant dams were exposed to glyoxal through drinking water (0.0125%, 0.025%, 0.05%, 0.1%) or regular tap water. Female and male offspring were housed separately from PND21 and continued with the same treatment. One group were only exposed to 0.1% glyoxal from postnatal day (PND) 21. There was no difference in the number of intestinal tumours between control and treatment groups. However, exposure to 0.1% glyoxal starting in utero and at PND21 caused a significant increase in tumour size in the small intestine for male and female mice in comparison with respective control groups. This study suggests that glyoxal has tumour growth promoting properties in the small intestine in Min mice.
Department of Toxicology and Risk Assessment, Domain for Infection Control and Environmental Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403 Oslo, Norway. Electronic address: camilla.svendsen@fhi.no.
Camilla
C
Svendsen
Department of Toxicology and Risk Assessment, Domain for Infection Control and Environmental Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403 Oslo, Norway.
Anja Hortemo
AH
Høie
Office of the Director-General, Norwegian Institute of Public Health, Oslo, Norway.
Jan
J
Alexander
Institute of Biochemistry, Graz University of Technology, Graz, Austria.
Michael
M
Murkovic
Department of Toxicology and Risk Assessment, Domain for Infection Control and Environmental Health, Norwegian Institute of Public Health, PO Box 4404, Nydalen, 0403 Oslo, Norway.
Trine
T
Husøy
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D005506:Food Contamination; D006037:Glyoxal / Q000633:toxicity*; D007414:Intestinal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL
D006037:Glyoxal
Apc Min mouse model; Carcinogenicity; Dicarbonyls; Food processing contaminants; Glyoxal