Lessons from making the Structural Classification of Proteins (SCOP) and their implications for protein structure modelling.
The Structural Classification of Proteins (SCOP) database has facilitated the development of many tools and algorithms and it has been successfully used in protein structure prediction and large-scale genome annotations. During the development of SCOP, numerous exceptions were found to topological rules, along with complex evolutionary scenarios and peculiarities in proteins including the ability to fold into alternative structures. This article reviews cases of structural variations observed for individual proteins and among groups of homologues, knowledge of which is essential for protein structure modelling.
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, U.K. tony@mrc-lmb.cam.ac.uk.
Antonina
A
Andreeva
D000465:Algorithms; D003198:Computer Simulation; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000145:classification / Q000378:metabolism*
D011506:Proteins
Structural Classification of Proteins (SCOP); homology modelling; metamorphic proteins; protein structure evolution