Differential induction of type I interferons in macaques by wild-type measles virus alone or with the hemagglutinin protein of the Edmonston vaccine strain.
Measles vaccines are highly effective and safe; however, the mechanism(s) underlying their attenuation has not been well understood. In this study, type I IFNs (IFN-α and IFN-β) induction in macaques infected with measles virus (MV) strains was examined. Type I IFNs were not induced in macaques infected with wild-type MV. However, IFN-α was sharply induced in most macaques infected with recombinant wild-type MV bearing the hemagglutinin (H) protein of the Edmonston vaccine strain. These results indicate that the H protein of MV vaccine strains may have a role in MV attenuation.
Department of Infection Biology.
Nguyen
N
Van Nguyen
Department of Infection Biology.
Sei-Ich
SI
Kato
Department of Infection Biology.
Kyosuke
K
Nagata
Laboratory of Environmental Microbiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Kaoru
K
Takeuchi
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D004195:Disease Models, Animal; D015870:Gene Expression; D006389:Hemagglutinins, Viral / Q000276:immunology*; D007114:Immunization; D007370:Interferon Type I / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D007963:Leukocytes, Mononuclear; D008251:Macaca; D008457:Measles / Q000235:genetics / Q000276:immunology / Q000517:prevention & control; D008458:Measles Vaccine / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013997:Time Factors
D006389:Hemagglutinins, Viral; D007370:Interferon Type I; D008458:Measles Vaccine; D012333:RNA, Messenger
hemagglutinin protein; interferon; macaque; measles virus