The potential role of some phytochemicals in recognition of mitochondrial damage-associated molecular patterns.
Mitochondria are the source of damage-associated molecular patterns (DAMPs). DAMPs modulate responses to stress and trauma in animals, influencing the onset of many diseases. Dietary phytochemicals, which target various cellular molecules, are potential modulators of immunological status. In this review the existence of the possible impact of some plant-derived compounds with proven anti-cancer and anti-inflammatory properties (isothiocyanates and curcumin) on DAMPs recognition is highlighted. Special consideration is given to the mtDNA recognizing Toll-like receptor 9 and formyl peptide receptors. In the context of the phytochemicals action, the role of these receptors in epithelial homeostasis is also discussed.
Department of Food Biotechnology, Faculty of Food Technology, The University of Agriculture in Kraków, Poland. Electronic address: m.pierzchalska@ur.krakow.pl.
Malgorzata
M
Pierzchalska
Department of Food Biotechnology, Faculty of Food Technology, The University of Agriculture in Kraków, Poland.
Maja
M
Grabacka
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000378:metabolism*; D004272:DNA, Mitochondrial / Q000378:metabolism; D004847:Epithelial Cells / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D008928:Mitochondria / Q000737:chemistry* / Q000473:pathology*; D064209:Phytochemicals / Q000378:metabolism*; D015398:Signal Transduction; D051217:Toll-Like Receptor 9 / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D004272:DNA, Mitochondrial; D064209:Phytochemicals; D051217:Toll-Like Receptor 9
Curcumin; DAMPs; Formyl peptide receptors; Innate immunity; Mucosal epithelia; Sulforaphane; Toll-like receptor 9