Insights into sensory hair cell regeneration from the zebrafish lateral line.
Loss of mechanosensory hair cells in the inner ear leads to loss of hearing. In humans this results in permanent deafness, as mammals are largely unable to regenerate hair cells. In contrast, zebrafish robustly regenerate hair cells in the sensory lateral line and ear and recent gene expression and time-lapse analyses of cell behaviors at the single cell level have greatly advanced our understanding of the mechanisms responsible for hair cell regeneration. In the lateral line, hair cell regeneration is controlled via dynamic interactions between Notch and Wnt/β-catenin signaling, and likely also between Fgf and the retinoic acid signaling pathways. Less is known about what initiates regeneration and we discuss potential pathways that may trigger proliferation after hair cell damage.
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Jonathan S
JS
Kniss
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Linjia
L
Jiang
Stowers Institute for Medical Research, Kansas City, MO 64110, USA. Electronic address: pio@stowers.org.
Tatjana
T
Piotrowski
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics*; D007758:Ear, Inner / Q000254:growth & development / Q000293:injuries; D006198:Hair Cells, Auditory / Q000378:metabolism*; D006801:Humans; D051880:Receptors, Notch / Q000235:genetics; D012038:Regeneration / Q000235:genetics*; D060449:Wnt Signaling Pathway / Q000235:genetics; D015027:Zebrafish / Q000235:genetics / Q000254:growth & development
D051880:Receptors, Notch