Bioavailability of anthocyanins and colonic polyphenol metabolites following consumption of aronia berry extract.
A single-dose pharmacokinetic trial was conducted in 6 adults to evaluate the bioavailability of anthocyanins and colonic polyphenol metabolites after consumption of 500mg aronia berry extract. UHPLC-MS methods were developed to quantitate aronia berry polyphenols and their metabolites in plasma and urine. While anthocyanins were bioavailable, microbial phenolic catabolites increased ∼10-fold more than anthocyanins in plasma and urine. Among the anthocyanins, cyanidin-3-O-galactoside was rapidly metabolized to peonidin-3-O-galactoside. Aronia polyphenols were absorbed and extensively metabolized with tmax of anthocyanins and other polyphenol catabolites from 1.0h to 6.33h in plasma and urine. Despite significant inter-individual variation in pharmacokinetic parameters, concentrations of polyphenol metabolites in plasma and urine at 24h were positively correlated with total AUC in plasma and urine (r=0.93, and r=0.98, respectively). This suggests that fasting blood and urine collections could be used to estimate polyphenol bioavailability and metabolism after aronia polyphenol consumption.
Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Rd Extension, Unit 4017, Storrs, CT 06269-4017, United States.
Liyang
L
Xie
Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Rd Extension, Unit 4017, Storrs, CT 06269-4017, United States.
Sang Gil
SG
Lee
Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Rd Extension, Unit 4017, Storrs, CT 06269-4017, United States.
Terrence M
TM
Vance
Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Rd Extension, Unit 4017, Storrs, CT 06269-4017, United States.
Ying
Y
Wang
Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Rd Extension, Unit 4017, Storrs, CT 06269-4017, United States.
Bohkyung
B
Kim
Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Rd Extension, Unit 4017, Storrs, CT 06269-4017, United States.
Ji-Young
JY
Lee
Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Rd Extension, Unit 4017, Storrs, CT 06269-4017, United States.
Ock K
OK
Chun
Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Rd Extension, Unit 4017, Storrs, CT 06269-4017, United States; Department of Food Science, University of Wisconsin-Madison, United States. Electronic address: bwbolling@wisc.edu.
Bradley W
BW
Bolling
D000328:Adult; D000872:Anthocyanins / Q000008:administration & dosage / Q000378:metabolism*; D001682:Biological Availability; D003106:Colon / Q000378:metabolism*; D004435:Eating / Q000502:physiology; D005260:Female; D005638:Fruit / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D046936:Photinia / Q000378:metabolism*; D010865:Pilot Projects; D010936:Plant Extracts / Q000008:administration & dosage / Q000378:metabolism*; D059808:Polyphenols / Q000378:metabolism*; D055815:Young Adult
D000872:Anthocyanins; D010936:Plant Extracts; D059808:Polyphenols
Anthocyanin; Aronia; Cyanidin; Ferulic acid; Metabolism; Pharmacokinetic; Polyphenol; UHPLC-MS