Clinical Inquiry: Which nonhormonal treatments are effective for hot flashes?
Selective serotonin reuptake inhibitors (SSRIs [fluoxetine, sertraline, paroxetine]) and the selective norepinephrine reuptake inhibitor (SNRI) venlafaxine, as well as clonidine and gabapentin, reduce hot flashes by about 25% (approximately one per day) in women with and without a history of breast cancer. No studies compare medications against each other to determine a single best option.
University of Washington at Valley Family Medicine Residency, Renton, WA, USA.
Gary
G
Kelsberg
University of Washington at Valley Family Medicine Residency, Renton, WA, USA.
Leticia
L
Maragh
University of Washington Health Sciences Library, Seattle, WA, USA.
Sarah
S
Safranek
D000588:Amines / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D005260:Female; D000077206:Gabapentin; D019584:Hot Flashes / Q000188:drug therapy*; D006801:Humans; D007529:Isoflavones / Q000627:therapeutic use; D008593:Menopause; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D000068760:Serotonin and Noradrenaline Reuptake Inhibitors / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
D000588:Amines; D000928:Antidepressive Agents; D003509:Cyclohexanecarboxylic Acids; D000077206:Gabapentin; D007529:Isoflavones; D017367:Selective Serotonin Reuptake Inhibitors; D000068760:Serotonin and Noradrenaline Reuptake Inhibitors; D005680:gamma-Aminobutyric Acid