[The corneal wound healing and the extracellular matrix].
The cornea is the first refractive element of the eye. The transparency of the cornea results from the regularly arranged collagen fibrils, forming lamellar structure and the leucin rich proteoglycans, which make interactions between the fibrils. The adult cornea consists mainly of fibril-forming collagens. The cornea has less amount of fibril associated and non-fibrillar collagens. The main proteoglycans of the cornea are keratan-sulfate proteoglycans and it also contains dermatan-sulfate proteoglycans. Disorders of the proteoglycan synthesis lead to the disruption of the unique pattern and result in thicker collagen fibrils. The abnormal structure of the extracellular matrix can generate corneal disorders and the loss of corneal transparency. Furthermore, proteoglycans and collagens have an important role in wound healing. In injury the keratocytes produce higher amounts of collagens and proteoglycans mediated by growth factors. Depending on the ratio of the cells and growth factors the extracellular matrix returns to normal or corneal scar tissue develops.
Patológiai Intézet, Neuropatológiai Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen, Nagyerdei krt. 98., 4032.
Gréta
G
Varkoly
Patológiai Intézet, Neuropatológiai Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen, Nagyerdei krt. 98., 4032.
János
J
Bencze
Patológiai Intézet, Neuropatológiai Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen, Nagyerdei krt. 98., 4032.
Tibor
T
Hortobágyi
Klinikai Központ, Szemklinika, Debreceni Egyetem Debrecen, Nagyerdei krt. 98., 4032.
László
L
Módis
D003094:Collagen / Q000378:metabolism*; D065306:Corneal Injuries / Q000378:metabolism / Q000503:physiopathology*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D011509:Proteoglycans / Q000378:metabolism*; D014945:Wound Healing
D011509:Proteoglycans; D003094:Collagen
corneal collagens; corneal extracellular matrix; corneal proteoglycans; corneal wound healing; cornealis extracelluláris mátrix; cornealis kollagének; cornealis proteoglikánok; cornealis sebgyógyulás