Interleukin-6: an emerging regulator of pathological pain.
Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been widely demonstrated that neuroinflammation plays a critical role in the development of pathological pain. Recently, various pathological pain models have shown elevated expression levels of interleukin-6 and its receptor in the spinal cord and dorsal root ganglia. Additionally, the administration of interleukin-6 could cause mechanical allodynia and thermal hyperalgesia, and an intrathecal injection of anti-interleukin-6 neutralizing antibody alleviated these pain-related behaviors. These studies indicated a pivotal role of interleukin-6 in pathological pain. In this review, we summarize the recent progress in understanding the roles and mechanisms of interleukin-6 in mediating pathological pain associated with bone cancer, peripheral nerve injury, spinal cord injury, chemotherapy-induced peripheral neuropathy, complete Freund's adjuvant injection, and carrageenan injection. Understanding and regulating interleukin-6 could be an interesting lead to novel therapeutic strategies for pathological pain.
Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ya-Qun
YQ
Zhou
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zheng
Z
Liu
Department of Anesthesiology, Shenzhen Second People's Hospital, Shenzhen, China.
Zhi-Heng
ZH
Liu
Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Shu-Ping
SP
Chen
Department of Neurobiology and Key Laboratory of Neurological Diseases of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Man
M
Li
Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Allahverdi
A
Shahveranov
Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. dy0711@gmail.com.
Da-Wei
DW
Ye
Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yu-Ke
YK
Tian
D000818:Animals; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology* / Q000633:toxicity; D010146:Pain / Q000139:chemically induced* / Q000378:metabolism* / Q000473:pathology; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
C508600:IL6 protein, human; D015850:Interleukin-6
Bone cancer pain; Inflammatory pain; Interleukin-6; Neuropathic pain