The relationship between serum albumin levels and 24-h ambulatory blood pressure monitoring recordings in non-diabetic essential hypertensive patients.
OBJECTIVE
The goal of this study was to evaluate the relationship between serum albumin levels and 24-hour ambulatory blood pressure monitoring (24-h ABPM) recordings in non-diabetic essential hypertensive patients.


METHODS
A total of 354 patients (mean [SD] age: 55.5 [14.3] years, 50% females) with essential hypertension and 24-h ABPM recordings were included. Patient 24-h nighttime and daytime ABPM values, systolic and diastolic dipping status and average nocturnal dipping were recorded. The correlations between serum albumin levels and nocturnal systolic and diastolic dipping were evaluated, and correlates of average nocturnal systolic dipping were determined via a linear regression model.


RESULTS
Overall, 73.2% of patients were determined to be non-dippers. The mean (SD) levels of serum albumin (4.2 [0.3] g/dL vs. 4.4 [0.4] g/dL, p<0.001) and the average nocturnal systolic (15.2 [4.8] mmHg vs. 0.3 [6.6] mmHg, p<0.001) and diastolic dipping (4.2 [8.6] mmHg vs. 18.9 [7.0] mmHg, p<0.001) were significantly lower in non-dippers than in dippers. A significant positive correlation was noted between serum albumin levels and both systolic (r=0.297, p<0.001) and diastolic dipping (r=0.265, p<0.001). The linear regression analysis revealed that for each one-unit increase in serum albumin, the average nocturnal dip in systolic BP increased by 0.17 mmHg (p=0.033).


CONCLUSIONS
Our findings indicate an association between serum albumin levels and the deterioration of circadian BP rhythm among essential hypertensive patients along with the identification of a non-dipper pattern in more than two-thirds of patients. Our findings emphasize the importance of serum albumin levels, rather than urinary albumin excretion, as an independent predictor of nocturnal systolic dipping, at least in non-diabetic essential hypertensive patients with moderate proteinuria.
Sisli Etfal Training and Research Hospital, Department of Nephrology, Istanbul, Turkey.
Elbis
E
Ahbap
Sisli Etfal Training and Research Hospital, Department of Nephrology, Istanbul, Turkey.
Tamer
T
Sakaci
Recep Tayyip Erdogan University, School of Medicine, Rize Educational and Research Hospital, Internal Medicine, Nephrology, Rize, Turkey.
Ekrem
E
Kara
Sisli Etfal Training and Research Hospital, Department of Nephrology, Istanbul, Turkey.
Tuncay
T
Sahutoglu
Sisli Etfal Training and Research Hospital, Department of Nephrology, Istanbul, Turkey.
Yener
Y
Koc
Sisli Etfal Training and Research Hospital, Department of Nephrology, Istanbul, Turkey.
Taner
T
Basturk
Sisli Etfal Training and Research Hospital, Department of Nephrology, Istanbul, Turkey.
Mustafa
M
Sevinc
Sisli Etfal Training and Research Hospital, Department of Nephrology, Istanbul, Turkey.
Cuneyt
C
Akgol
Sisli Etfal Training and Research Hospital, Department of Nephrology, Istanbul, Turkey.
Arzu O
AO
Kayalar
Sisli Etfal Training and Research Hospital, Department of Nephrology, Istanbul, Turkey.
Zuhal A
ZA
Ucar
Sisli Etfal Training and Research Hospital, Department of Nephrology, Istanbul, Turkey.
Feyza
F
Bayraktar
Sisli Etfal Training and Research Hospital, Department of Nephrology, Istanbul, Turkey.
Abdulkadir
A
Unsal
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000503:physiopathology; D001794:Blood Pressure / Q000502:physiology; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods*; D002940:Circadian Rhythm / Q000502:physiology; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis* / Q000502:physiology
D012709:Serum Albumin