Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation.
Functional brain hubs are key integrative regions in brain networks. Recently, brain hubs identified through resting-state fMRI have emerged as interesting targets to increase understanding of the relationships between large-scale functional networks and psychopathology. However, few studies have directly addressed the replicability and consistency of the hub regions identified and their association with symptoms. Here, we used the eigenvector centrality (EVC) measure obtained from graph analysis of two large, independent population-based samples of children and adolescents (7-15 years old; total N=652; 341 subjects for site 1 and 311 for site 2) to evaluate the replicability of hub identification. Subsequently, we tested the association between replicable hub regions and psychiatric symptoms. We identified a set of hubs consisting of the anterior medial prefrontal cortex and inferior parietal lobule/intraparietal sulcus (IPL/IPS). Moreover, lower EVC values in the right IPS were associated with psychiatric symptoms in both samples. Thus, low centrality of the IPS was a replicable sign of potential vulnerability to mental disorders in children. The identification of critical and replicable hubs in functional cortical networks in children and adolescents can foster understanding of the mechanisms underlying mental disorders.
Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Santo Andre, Brazil; Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil; Department of Radiology, School of Medicine, University of Sao Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil. Electronic address: joao.sato@ufabc.edu.br.
João Ricardo
JR
Sato
Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Santo Andre, Brazil; Department of Radiology, School of Medicine, University of Sao Paulo, Brazil.
Claudinei Eduardo
CE
Biazoli
Department of Psychiatry, Federal University of Rio Grande do Sul and Psychiatric Service, Hospital de Clinicas de Porto Alegre, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
Giovanni Abrahão
GA
Salum
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
Ary
A
Gadelha
Institute of Psychiatry, King's College London, United Kingdom; Institute for Biological and Medical Engineering, Faculties of Engineering, Medicine and Biological Sciences, P. Catholic University of Chile, Chile, Chile.
Nicolas
N
Crossley
Bioinformatics Program, Institute of Mathematics and Statistics, University of Sao Paulo, Brazil; Department of Radiology, School of Medicine, University of Sao Paulo, Brazil.
Gilson
G
Vieira
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
André
A
Zugman
Department of Psychiatry, Federal University of Rio Grande do Sul and Psychiatric Service, Hospital de Clinicas de Porto Alegre, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
Felipe Almeida
FA
Picon
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
Pedro Mario
PM
Pan
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil; Department of Psychiatry, University of São Paulo School of Medicine, São Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
Marcelo Queiroz
MQ
Hoexter
Department of Psychiatry, Federal University of Rio Grande do Sul and Psychiatric Service, Hospital de Clinicas de Porto Alegre, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
Mauricio
M
Anés
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
Luciana Monteiro
LM
Moura
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
Marco Antonio Gomes
MA
Del'Aquilla
Department of Radiology, School of Medicine, University of Sao Paulo, Brazil.
Edson Amaro
EA
Junior
Institute of Psychiatry, King's College London, United Kingdom.
Philip
P
Mcguire
Department of Psychiatry, Federal University of Rio Grande do Sul and Psychiatric Service, Hospital de Clinicas de Porto Alegre, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
Luis Augusto
LA
Rohde
Department of Psychiatry, University of São Paulo School of Medicine, São Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
Euripedes Constantino
EC
Miguel
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
Rodrigo Affonseca
RA
Bressan
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil; National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, Brazil.
Andrea Parolin
AP
Jackowski
D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D063132:Connectome / Q000379:methods / Q000592:standards*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards*; D008297:Male; D009434:Neural Pathways / Q000000981:diagnostic imaging; D065886:Neurodevelopmental Disorders / Q000000981:diagnostic imaging* / Q000453:epidemiology; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging; D011599:Psychopathology; D011897:Random Allocation; D015203:Reproducibility of Results; D012146:Rest
Children; Connectivity; Development; Replication; Resting state; fMRI