Association of the miR-146a rs2910164 polymorphism with gastric cancer susceptibility and prognosis.
OBJECTIVE
Single nucleotide polymorphisms in miRNA-coding region may be involved in the development or progression of gastric cancer (GC).


METHODS
Six SNPs (miR-146a rs2910164, miR-196a2 rs11614913, miR-27a rs895819, miR-423 rs6505162, miR-608 rs4919510, miR-149 rs2292832) were genotyped in 898 histologically confirmed GC cases and 992 controls in this hospital-based case-control study.


RESULTS
The G/G genotype of rs2910164 was associated with reduced risk of GC (odds ratio: 0.76, 95% CI: 0.60-0.97; p = 0.024). Meanwhile, in 838 GC cases receiving radical tumorectomy, cases bearing the G/G genotype of rs2910164 had shorter survival time comparing to cases with C/C or C/G genotype (hazard ratio: 1.36, 95% CI: 1.04-1.78, p = 0.023).


CONCLUSIONS
rs2910164 of miR-146a is associated with GC.
Beijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing, PR China.|Division of Clinical Research, First Hospital of Jilin University, Changchun, PR China.
Jing
J
Jiang
Division of Clinical Research, First Hospital of Jilin University, Changchun, PR China.
Zhi-Fang
ZF
Jia
Division of Clinical Research, First Hospital of Jilin University, Changchun, PR China.
Dong-Hui
DH
Cao
Division of Clinical Research, First Hospital of Jilin University, Changchun, PR China.
Yan-Hua
YH
Wu
Beijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing, PR China.
Zhi-Wei
ZW
Sun
Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, PR China.
Xue-Yuan
XY
Cao
D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D005500:Follow-Up Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality* / Q000628:therapy
C542542:MIRN146 microRNA, human; D035683:MicroRNAs
gastric cancer; miRNA; overall survival; polymorphism; susceptibility