Renal replacement therapy in Europe: a summary of the 2013 ERA-EDTA Registry Annual Report with a focus on diabetes mellitus.
BACKGROUND
This article provides a summary of the 2013 European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry Annual Report (available at http://www.era-edta-reg.org), with a focus on patients with diabetes mellitus (DM) as the cause of end-stage renal disease (ESRD).


METHODS
In 2015, the ERA-EDTA Registry received data on renal replacement therapy (RRT) for ESRD from 49 national or regional renal registries in 34 countries in Europe and bordering the Mediterranean Sea. Individual patient data were provided by 31 registries, while 18 registries provided aggregated data. The total population covered by the participating registries comprised 650 million people.


RESULTS
In total, 72 933 patients started RRT for ESRD within the countries and regions reporting to the ERA-EDTA Registry, resulting in an overall incidence of 112 per million population (pmp). The overall prevalence on 31 December 2013 was 738 pmp (n = 478 990). Patients with DM as the cause of ESRD comprised 24% of the incident RRT patients (26 pmp) and 17% of the prevalent RRT patients (122 pmp). When compared with the USA, the incidence of patients starting RRT pmp secondary to DM in Europe was five times lower and the incidence of RRT due to other causes of ESRD was two times lower. Overall, 19 426 kidney transplants were performed (30 pmp). The 5-year adjusted survival for all RRT patients was 60.9% [95% confidence interval (CI) 60.5-61.3] and 50.6% (95% CI 49.9-51.2) for patients with DM as the cause of ESRD.
Department of Medical Informatics, Academic Medical Center , ERA-EDTA Registry, University of Amsterdam , 1100 DE Amsterdam , The Netherlands.
Anneke
A
Kramer
Department of Medical Informatics, Academic Medical Center , ERA-EDTA Registry, University of Amsterdam , 1100 DE Amsterdam , The Netherlands.
Maria
M
Pippias
Department of Medical Informatics, Academic Medical Center , ERA-EDTA Registry, University of Amsterdam , 1100 DE Amsterdam , The Netherlands.
Vianda S
VS
Stel
Department of Medical Informatics, Academic Medical Center , ESPN/ERA-EDTA Registry, Universiteit van Amsterdam , Amsterdam , The Netherlands.
Marjolein
M
Bonthuis
Aragon Renal Registry , Zaragoza , Spain.
José Maria
JM
Abad Diez
Hellenic Renal Registry, Board of Registry, Coordination and Control of RRT , General Hospital of Athens 'G. Gennimatas' , Athens , Greece.
Nikolaos
N
Afentakis
Public Health Directorate, Asturias , Spain.
Ramón
R
Alonso de la Torre
Swiss Dialysis Registry, Renal Division, Stadtspital Waid Zürich , Zurich , Switzerland.
Patrice
P
Ambuhl
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; Department of Nephrology Issues of Transplanted Kidney, Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow, Russian Federation.
Boris
B
Bikbov
Regional Transplant Coordination Office , Galicia , Spain.
Encarnación
E
Bouzas Caamaño
Department of Nephrology, Dialysis and Transplantation, Clinical Hospital Center Rijeka , School of Medicine University of Rijeka , Rijeka , Croatia.
Ivan
I
Bubic
Department of Nephrology, University Medical Center Ljubljana, Ljubljana, Slovenia; Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Jadranka
J
Buturovic-Ponikvar
UK Renal Registry , Southmead Hospital , Bristol , UK.
Fergus J
FJ
Caskey
Information System of Regional Transplant Coordination in Andalucia (SICATA) , Andalucia , Spain.
Pablo
P
Castro de la Nuez
Department of Internal Medicine , Riga Stradins University , Riga , Latvia.
Harijs
H
Cernevskis
French-Belgian ESRD Registry , Brussels , Belgium.
Frederic
F
Collart
Catalan Renal Registry, Catalan Transplant Organization, Health Department , Generalitat of Catalonia , Barcelona , Spain.
Jordi
J
Comas Farnés
Dirección General de Salud Pública, Servicio Extremeño de Salud , Consejería de Sanidad y Políticas Sociales, Junta de Extremadura , Spain.
Maria de Los Ángeles
Mde L
Garcia Bazaga
Department of Nephrology, Dialysis and Hypertension , Dutch-speaking Belgian Renal Registry (NBVN) , Sint-Niklaas , Belgium.
Johan
J
De Meester
Técnico Registro de Enfermos Renales Comunitat Valenciana, Servicio de Estudios Epidemiológicos y Registros Sanitarios, Subdirección General Epidemiología, Dirección General Salut Pública, Consellería Sanitat , Valencian Region , Spain.
Manuel
M
Ferrer Alamar
Abdominal Center, Nephrology and Finnish Registry for Kidney Diseases , Helsinki University Central Hospital , Helsinki , Finland.
Patrik
P
Finne
"Carol Davila" University of Medicine and Pharmacy , "Dr C Davila" Teaching Hospital of Nephrology, Romanian Renal Registry , Bucharest , Romania.
Liliana
L
Garneata
Department of Nephrology and Hypertension , Meir Medical Center, Kfar-Saba and Sackler Faculty of Medicine , Tel-Aviv , Israel.
Eliezer
E
Golan
Department of Medicine , Roskilde Hospital, University of Copenhagen , Copenhagen , Denmark.
James
J
G Heaf
Nefrovisie Renine, Dutch Renal Registry , Leiden , The Netherlands.
Marc
M
Hemmelder
Nephrology Department , Nicosia General Hospital , Nicosia , Cyprus.
Kyriakos
K
Ioannou
Department of Internal Medicine , Tbilisi State Medical University , Tbilisi , Georgia.
Nino
N
Kantaria
URDS , Kiev , Ukraine.
Mykola
M
Kolesnyk
Austrian Dialysis and Transplant Registry , Rohr , Austria.
Reinhard
R
Kramar
REIN Registry, Agence de la Biomédecine , Paris , France.
Mathilde
M
Lassalle
Department of Nephrology, Clinical Centre of Serbia , Belgrade University , Belgrade , Serbia.
Visnja
V
Lezaic
General University Hospital and 1st Medical Faculty, Department of Medicine , Charles University , Prague - Strahov , Czech Republic.
Frantisek
F
Lopot
Portuguese Society of Nephrology, Nephrology Department , University Hospital of Coimbra , Coimbra , Portugal.
Fernando
F
Macário
Unidad de Información Sobre Pacientes Renales de la Comunidad Autónoma del País Vasco (UNIPAR) , Basque Country , Spain.
Angela
A
Magaz
Registro Español de Enfermos Renales (REER), Organización Nacional de Trasplantes , Madrid , Spain.
Eduardo
E
Martín-Escobar
Scottish Renal Registry, Meridian Court , Glasgow , Scotland.
Wendy
W
Metcalfe
Department of Internal Medicine , Tartu University , Tartu , Estonia.
Mai
M
Ots-Rosenberg
Division of Nephrology, Landspitali - National University Hospital of Iceland, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Runolfur
R
Palsson
Servicio de Nefrología , Hospital Universitario Valdecilla , Santander, Cantabria , Spain.
Celestino
C
Piñera Celestino
Clinic for Hemodialysis, Clinical Center , University of Sarajevo , Sarajevo , Bosnia and Herzegovina.
Halima
H
Resić
Polish Renal Registry, Department of Nephrology, Transplantology and Internal Medicine , Medical University , Gdansk , Poland.
Boleslaw
B
Rutkowski
Registro de Enfermos Renales de la Región de Murcia, Servicio de Epidemiología, Consejería de Sanidad , IMIB-Arrixaca , Murcia , Spain.
Carmen
C
Santiuste de Pablos
Slovak Medical University , Bratislava , Slovakia.
Viera
V
Spustová
Department of Internal Medicine, Ryhov County Hospital, Jönköping, Sweden; Swedish Renal Registry, Jönköping, Sweden.
Maria
M
Stendahl
Service of Nephrology, Dialysis and Transplant , University Hospital Center , Tirana , Albania.
Ariana
A
Strakosha
Division of Nephrology, Department of Medicine, Medical School , Akdeniz University , Antalya , Turkey.
Gültekin
G
Süleymanlar
Registro de Enfermos Renales en Tratamiento Sustitutivo de Castilla-La Mancha , Hospital Virgen de la Salud , Castilla-La Mancha , Spain.
Marta
M
Torres Guinea
Norwegian Renal Registry, Renal Unit, Department for Transplant Medicine , Oslo University Hospital, Rikshospitalet , Oslo , Norway.
Anna
A
Varberg Reisæter
Dialysis Clinic , "Alexandrovska" University Hospital , Sofia Medical University , Sofia , Bulgaria.
Evgueniy
E
Vazelov
Department of Nephrology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; Lithuanian Nephrology, Dialysis and Transplantation Association, Nephrological Clinic, Hospital of Lithuanian University of Health Sciences Kaunas Clinics, Kaunas, Lithuania.
Edita
E
Ziginskiene
Division of Nephrology, Ambroise Paré University Hospital, APHP, University of Paris Ouest-Versailles-St-Quentin-en-Yvelines (UVSQ), Boulogne-Billancourt/Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U1018, CESP, Team 5, Villejuif, France.
Ziad A
ZA
Massy
Division of Nephrology , University Clinic , University of Würzburg , Würzburg , Germany.
Christoph
C
Wanner
Department of Medical Informatics, Academic Medical Center , ERA-EDTA Registry, University of Amsterdam , 1100 DE Amsterdam , The Netherlands.
Kitty J
KJ
Jager
Department of Medical Informatics, Academic Medical Center , ERA-EDTA Registry, University of Amsterdam , 1100 DE Amsterdam , The Netherlands.
Marlies
M
Noordzij
end-stage renal disease; incidence; prevalence; renal replacement therapy; survival