Cardiac Delayed Rectifier Potassium Channels in Health and Disease.
Cardiac delayed rectifier potassium channels conduct outward potassium currents during the plateau phase of action potentials and play pivotal roles in cardiac repolarization. These include IKs, IKr and the atrial specific IKur channels. In this article, we will review their molecular identities and biophysical properties. Mutations in the genes encoding delayed rectifiers lead to loss- or gain-of-function phenotypes, disrupt normal cardiac repolarization and result in various cardiac rhythm disorders, including congenital Long QT Syndrome, Short QT Syndrome and familial atrial fibrillation. We will also discuss the prospect of using delayed rectifier channels as therapeutic targets to manage cardiac arrhythmia.
Department of Pharmacology, College of Physicians & Surgeons of Columbia University, 630 West 168th Street, New York, NY 10032, USA.
Lei
L
Chen
Department of Pharmacology, College of Physicians & Surgeons of Columbia University, 630 West 168th Street, New York, NY 10032, USA.
Kevin J
KJ
Sampson
Department of Pharmacology, College of Physicians & Surgeons of Columbia University, 630 West 168th Street, New York, NY 10032, USA. Electronic address: rsk20@columbia.edu.
Robert S
RS
Kass
D001145:Arrhythmias, Cardiac; D051668:Delayed Rectifier Potassium Channels / Q000037:antagonists & inhibitors / Q000235:genetics; D004562:Electrocardiography; D006801:Humans; D008133:Long QT Syndrome; D009154:Mutation; D026902:Potassium Channel Blockers
D051668:Delayed Rectifier Potassium Channels; D026902:Potassium Channel Blockers
Atrial fibrillation; Delayed rectifiers; I(Kr); I(Ks); I(Kur); Long QT Syndrome; Short QT Syndrome