Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016).
On page 1310 J. S. Merzaban, A. E. Porter, and co-workers present fluorescently labeled RGD-targeted ZnO nanoparticles (NPs; green) for the targeted delivery of cytotoxic ZnO to integrin αvβ3 receptors expressed on triple negative breast cancer cells. Correlative light-electron microscopy shows that NPs dissolve into ionic Zn(2+) (blue) upon uptake and cause apoptosis (red) with intra-tumor heterogeneity, thereby providing a possible strategy for targeted breast cancer therapy. Cover design by Ivan Gromicho.
Department of Materials, Imperial College London, Royal School of Mines, Exhibition Road, London, SW7 2AZ, UK.
Basmah A
BA
Othman
Cell and Molecular Biology Research Laboratory, Faculty of Medical Sciences, Post Graduate Medical Institute, Anglia Ruskin University, Bishop Hall Lane, Chelmsford, CM1 1SQ, UK.
Christina
C
Greenwood
Cell Migration and Signaling Laboratory, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Engineering (KAUST), Thuwal, 23955-6900, Saudi Arabia.
Ayman F
AF
Abuelela
Department of Bioengineering, Imperial College London, Royal School of Mines, Exhibition Road, London, SW7 2AZ, UK.
Anil A
AA
Bharath
Department of Materials, Imperial College London, Royal School of Mines, Exhibition Road, London, SW7 2AZ, UK.
Shu
S
Chen
Department of Materials, Imperial College London, Royal School of Mines, Exhibition Road, London, SW7 2AZ, UK.
Ioannis
I
Theodorou
Department of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN, 47405, USA.
Trevor
T
Douglas
Department of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN, 47405, USA.
Maskai
M
Uchida
Department of Materials, Imperial College London, Royal School of Mines, Exhibition Road, London, SW7 2AZ, UK.
Mary
M
Ryan
Cell Migration and Signaling Laboratory, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Engineering (KAUST), Thuwal, 23955-6900, Saudi Arabia.
Jasmeen S
JS
Merzaban
Department of Materials, Imperial College London, Royal School of Mines, Exhibition Road, London, SW7 2AZ, UK.|Imperial College London and London Centre for Nanotechnology, London, SW7 2AZ, UK.
Alexandra E
AE
Porter
cellular targeting; cytotoxicity; integrin αvβ3 receptors; triple negative breast cancer cells; zinc oxide nanoparticles