Glucose-Derived Carbonaceous Nanospheres for Photoacoustic Imaging and Photothermal Therapy.
Carbon nanomaterials with small size and unique optical properties have attracted intensive interest for their promising biomedical applications. In this work, glucose-derived carbonaceous nanospheres (CNSs) with high photothermal conversion efficiency up to 35.1% are explored for the first time as a novel carbon-based theranostic agent. Different from most other carbon nanomaterials, the obtained CNSs are highly biocompatible and nontoxic because of their intrinsic hydrophilic property and the use of glucose as raw materials. Under near-infrared laser irradiation (808 nm, 6 W cm(-2)) for 10 min, less than 15% of PC-3M-IE8 cells exposed to CNSs aqueous dispersions (0.16 mg/mL) remained alive. After intravenous administration of CNSs aqueous dispersions into nude mice, the photoacoustic intensity of the tumor region is about 2.5 times higher than that of preinjection. These results indicate that CNSs are suitable for simultaneous photoacoustic imaging and photothermal ablation of cancer cells and can serve as promising biocompatible carbon-based agents for further clinical trials.
School of Materials Science and Engineering, Harbin Institute of Technology , Harbin, Heilongjiang 150001, Peoples' Republic of China.|MOE Key Laboratory of Micro-system and Micro-structures Manufacturing, Harbin Institute of Technology , Harbin, Heilongjiang 150080, Peoples' Republic of China.
Zhao-Hua
ZH
Miao
School of Life Science and Technology, Harbin Institute of Technology , Harbin, Heilongjiang 150080, Peoples' Republic of China.
Hui
H
Wang
School of Life Science and Technology, Harbin Institute of Technology , Harbin, Heilongjiang 150080, Peoples' Republic of China.
Huanjie
H
Yang
Condensed Matter Science and Technology Institute, School of Science, Harbin Institute of Technology , Harbin, Heilongjiang 150001, Peoples' Republic of China.
Zhenglin
Z
Li
School of Materials Science and Engineering, Harbin Institute of Technology , Harbin, Heilongjiang 150001, Peoples' Republic of China.|MOE Key Laboratory of Micro-system and Micro-structures Manufacturing, Harbin Institute of Technology , Harbin, Heilongjiang 150080, Peoples' Republic of China.
Liang
L
Zhen
School of Materials Science and Engineering, Harbin Institute of Technology , Harbin, Heilongjiang 150001, Peoples' Republic of China.|MOE Key Laboratory of Micro-system and Micro-structures Manufacturing, Harbin Institute of Technology , Harbin, Heilongjiang 150080, Peoples' Republic of China.
Cheng-Yan
CY
Xu
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D045744:Cell Line, Tumor; D005947:Glucose / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D054118:Nanospheres / Q000737:chemistry* / Q000627:therapeutic use*; D009369:Neoplasms / Q000628:therapy*; D061088:Photoacoustic Techniques / Q000379:methods*; D010789:Phototherapy / Q000379:methods*; D000068936:Theranostic Nanomedicine / Q000379:methods*
D001672:Biocompatible Materials; D005947:Glucose
biocompatibility; carbonaceous nanospheres; photoacoustic imaging; photothermal therapy; theranostic agents