A novel biomarker panel for irritable bowel syndrome and the application in the general population.
Biological markers that measure gut health and diagnose functional gastro-intestinal (GI) disorders, such as irritable bowel syndrome (IBS), are lacking. The objective was to identify and validate a biomarker panel associated with the pathophysiology of IBS that discriminates IBS from healthy controls (HC), and correlates with GI symptom severity. In a case-control design, various plasma and fecal markers were measured in a cohort of 196 clinical IBS patients and 160 HC without GI symptoms. A combination of biomarkers, which best discriminates between IBS and HC was identified and validated in an independent internal validation set and by permutation testing. The correlation between the biomarker panel and GI symptom severity was tested in IBS patients and in a general population cohort of 958 subjects. A set of 8 biomarker panel was identified to discriminate IBS from HC with high sensitivity (88.1%) and specificity (86.5%). The results for the IBS subtypes were comparable. Moreover, a moderate correlation was found between the biomarker panel and GI symptom scores in the IBS (r = 0.59, p < 0.001) and the general population cohorts (r = 0.51, p = 0.003). A novel multi-domain biomarker panel has been identified and validated, which correlated moderately to GI symptom severity in IBS and general population subjects.
Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands.|Division Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School for Nutrition, and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
Zlatan
Z
Mujagic
Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands.|Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Ettje F
EF
Tigchelaar
Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands.|Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Alexandra
A
Zhernakova
Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands.|Department Developmental Physiology and Nutrition, Danone Nutricia Research, Utrecht, The Netherlands.
Thomas
T
Ludwig
Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands.|Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands.
Javier
J
Ramiro-Garcia
Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands.|Department of Pharmacology and Toxicology, NUTRIM School for Nutrition, and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Agnieszka
A
Baranska
Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands.|Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Morris A
MA
Swertz
Division Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School for Nutrition, and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
Ad A M
AA
Masclee
Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands.|Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Cisca
C
Wijmenga
Department of Pharmacology and Toxicology, NUTRIM School for Nutrition, and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Frederik J
FJ
van Schooten
Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands.|Department of Pharmacology and Toxicology, NUTRIM School for Nutrition, and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Agnieszka
A
Smolinska
Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands.|Division Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School for Nutrition, and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
Daisy M A E
DM
Jonkers
D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D012372:ROC Curve; D055815:Young Adult
D015415:Biomarkers