WISP1 is a novel adipokine linked to metabolic parameters in gestational diabetes mellitus.
OBJECTIVE
To investigate Wnt1-inducible signaling pathway protein-1 (WISP1) levels and their correlation with metabolic parameters in pregnant women with gestational diabetes mellitus (GDM) and non-GDM healthy pregnant women.


METHODS
In this prospective cross-sectional study, the study group was composed of 62 women with GDM and 73 healthy pregnant women matched for age, body mass index (BMI) and gestational age. Blood samples were collected at 25-29th gestational week. Serum WISP1, betatrophin, glucose, fasting insulin, glycosylated hemoglobin A1c, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, C reactive protein, alanine aminotransferase and creatinine levels were measured. Homeostasis model assessment of insulin resistance (HOMA-IR) values was calculated. The level of significance was accepted as p < 0.05.


RESULTS
Circulating WISP1 in the GDM group was significantly higher than the control group (p <0.001). Further, WISP1 was positively correlated with BMI, HOMA-IR values and fasting glucose, fasting insulin, triglyceride, betatrophin levels. BMI, HOMA-IR and betatrophin independently and positively predicted WISP1 levels.


CONCLUSIONS
These results demonstrate a relationship between WISP1 and the metabolic parameters of GDM. And, WISP1 might be involved in the pathophysiology of GDM. As a part of this pathophysiological mechanism, the activation of WISP1 and betatrophin might take place through several ways; WISP1 and betatrophin might either use same signaling pathways and potentiate each other or they might also constitute the sequential steps of a common pathway.
a Department of Obstetrics , Gynecology and Reproductive Sciences, Yale University School of Medicine , New Haven , CT , USA.|b Department of Obstetrics and Gynecology , Kartal Dr. Lutfi Kirdar Education and Research Hospital , Istanbul , Turkey.
Gulcin
G
Sahin Ersoy
a Department of Obstetrics , Gynecology and Reproductive Sciences, Yale University School of Medicine , New Haven , CT , USA.|c Department of Obstetrics and Gynecology , Etlik Zubeyde Hanim Women's Health Education and Research Hospital , Ankara , Turkey.
Tugba
T
Altun Ensari
b Department of Obstetrics and Gynecology , Kartal Dr. Lutfi Kirdar Education and Research Hospital , Istanbul , Turkey.
Seda
S
Subas
b Department of Obstetrics and Gynecology , Kartal Dr. Lutfi Kirdar Education and Research Hospital , Istanbul , Turkey.
Burak
B
Giray
d Department of Family Medicine , Kartal Dr. Lutfi Kirdar Education and Research Hospital , Istanbul , Turkey , and.
Engin Ersin
EE
Simsek
e Department of Biochemistry , Cumhuriyet University Faculty of Pharmacy , Sivas , Turkey.
Ozge
O
Cevik
D054392:Adipokines / Q000097:blood / Q000502:physiology*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000032:analysis; D055511:CCN Intercellular Signaling Proteins / Q000097:blood / Q000502:physiology*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D011247:Pregnancy; D011518:Proto-Oncogene Proteins / Q000097:blood / Q000502:physiology*; D014280:Triglycerides / Q000097:blood
D054392:Adipokines; D015415:Biomarkers; D001786:Blood Glucose; D055511:CCN Intercellular Signaling Proteins; C116396:CCN4 protein, human; D007328:Insulin; D011518:Proto-Oncogene Proteins; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol
Betatrophin; HOMA-IR; WISP1; gestational diabetes mellitus