Molecular Basis of Functional Myocardial Potassium Channel Diversity.
Multiple types of voltage-gated K(+) and non-voltage-gated K(+) currents have been distinguished in mammalian cardiac myocytes based on differences in time-dependent and voltage-dependent properties and pharmacologic sensitivities. Many of the genes encoding voltage-gated K(+) (Kv) and non-voltage-gated K(+) (Kir and K2P) channel pore-forming and accessory subunits are expressed in the heart, and a variety of approaches have been, and continue to be, used to define the molecular determinants of native cardiac K(+) channels and to explore the molecular mechanisms controlling the diversity, regulation, and remodeling of these channels in the normal and diseased myocardium.
Department of Internal Medicine, Washington University Medical School, 660 South Euclid Avenue, Box 8086, St Louis, MO 63110, USA; Department of Developmental Biology, Washington University Medical School, St Louis, MO 63110, USA. Electronic address: jnerbonne@wustl.edu.
Jeanne M
JM
Nerbonne
D000200:Action Potentials; D000818:Animals; D051668:Delayed Rectifier Potassium Channels / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D051379:Mice; D009206:Myocardium / Q000166:cytology / Q000648:ultrastructure; D032383:Myocytes, Cardiac; D021122:Protein Subunits; D051381:Rats
D051668:Delayed Rectifier Potassium Channels; D021122:Protein Subunits
Accessory subunits; Action potentials; Dispersion; K(+) channels; Macromolecular protein complexes; Pore-forming subunits; Propagation; Repolarization