Physical, morphological, and wound healing properties of a polyurethane foam-film dressing.
BACKGROUND
We investigated the physicochemical properties of Medifoam® N and its wound healing performance compared to other commercially available polyurethane (PU) foam dressing in vitro and in vivo to gain insight in their clinical performance.


METHODS
Wound contact layer and cross-section of eleven polyurethane foam dressings were assessed with field-emission scanning electron microscope. Thickness, density, tensile strength, elongation, moisture-vapor transmission rate (MVTR), retention and absorptivity were measured to compare physical properties. Phosphate-buffered saline (PBS) solution absorption patterns were compared. An animal model for wound-healing was applied to validate in vitro findings.


RESULTS
Among eleven tested foam dressings, Medifoam® N has the smallest pore and cell sizes with excellent uniformity, i.e. it has 25 ~ 75 μm on the wound contact layer and 100 ~ 350 μm in the cross-section while other dressings have a larger pose size with larger variability. Compared to other PU foams, Medifoam® N also has moderate thickness, density, tensile strength, elongation and MVTR. Furthermore, it has excellent fluid absorption and retention capacity. These intrinsic properties of Medifoam® N contributed to improve fluid absorption patterns, i.e. other dressing material flawed out PBS solution on the dressings while Medifoam® N retained all the tested solutions. In animal wound-healing study, Medifoam® N treated animals showed excellent angiogenesis and collagen deposition even though epithelial recovery rate was not significantly different to other dressings.


CONCLUSIONS
Medifoam® N has optimized physical properties and thus improved fluid absorption/retention capacity. Compared to other dressings, Medifoam® N showed excellent fluid absorption patterns and these characteristics contributed to improved wound healing and excellent angiogenic potential. We found that Medifoam® N showed the best results among the employed dressing samples.
Genewel Co. Ltd., Gyeonggi-do, Korea.
Seung Moon
SM
Lee
Genewel Co. Ltd., Gyeonggi-do, Korea.
Il Kyu
IK
Park
Genewel Co. Ltd., Gyeonggi-do, Korea.
Yong Soo
YS
Kim
Genewel Co. Ltd., Gyeonggi-do, Korea.
Hyun Jung
HJ
Kim
Mundipharma Pte. Ltd., Singapore, Singapore.
Hanlim
H
Moon
Mundipharma Pte. Ltd., Singapore, Singapore.
Stefan
S
Mueller
Biomedical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan, 602-739 Republic of Korea.
Young-Il
YI
Jeong
Absorption pattern; Absorption/retention capacity; Foam dressing; Moisture-vapor transmission rate; Porosity; Wound healing