Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells.
Eight new sesquiterpenes (1-8), along with seven known sesquiterpenes (9-15), were isolated from a methanol extract of the flowers of Inula japonica. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. All of isolates were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 cells, with their IC50 values ranging from 1.9 to 15.4 μM.
College of Pharmacy, Chungbuk National University , Cheongju 28644, Korea.
Qinghao
Q
Jin
College of Pharmacy, Chungbuk National University , Cheongju 28644, Korea.
Jin Woo
JW
Lee
College of Pharmacy, Chungbuk National University , Cheongju 28644, Korea.
Hari
H
Jang
College of Pharmacy, Chungbuk National University , Cheongju 28644, Korea.
Ji Eun
JE
Choi
Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University , Seoul 02841, Korea.
Dongho
D
Lee
College of Pharmacy, Chungbuk National University , Cheongju 28644, Korea.
Jin Tae
JT
Hong
College of Pharmacy, Chungbuk National University , Cheongju 28644, Korea.
Youngsoo
Y
Kim
College of Pharmacy, Chungbuk National University , Cheongju 28644, Korea.
Mi Kyeong
MK
Lee
College of Pharmacy, Chungbuk National University , Cheongju 28644, Korea.
Bang Yeon
BY
Hwang
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D035264:Flowers / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D038143:Inula / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis*; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry; D000067996:RAW 264.7 Cells; D056910:Republic of Korea; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007783:Lactones; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D009569:Nitric Oxide