New ent-Clerodane and Abietane Diterpenoids from the Roots of Kenyan Croton megalocarpoides Friis & M. G. Gilbert.
The roots of the endangered medicinal plant Croton megalocarpoides collected in Kenya were investigated and twenty-two compounds isolated. Among them were twelve new ent-clerodane (1-12) and a new abietane (13) diterpenoids, alongside the known crotocorylifuran (4 a), two known abietane and four known ent-trachylobane diterpenoids, and the triterpenoids, lupeol and acetyl aleurotolic acid. The structures of the compounds were determined using NMR, HRMS and ECD. The isolated compounds were evaluated against a series of microorganisms (fungal and bacteria) and also against Plasmodium falciparum, however no activity was observed.
Department of Chemistry, University of Nairobi, Nairobi, Kenya.
Beth
B
Ndunda
Department of Chemistry, University of Surrey, Guildford, Surrey, United Kingdom.
Moses K
MK
Langat
Department of Chemistry, University of Surrey, Guildford, Surrey, United Kingdom.
Dulcie A
DA
Mulholland
Department of Chemistry, University of Surrey, Guildford, Surrey, United Kingdom.
Harry
H
Eastman
National Centre for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS, USA.
Melissa R
MR
Jacob
National Centre for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS, USA.
Shabana I
SI
Khan
National Centre for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS, USA.
Larry A
LA
Walker
National Centre for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS, USA.
Ilias
I
Muhammad
Department of Chemistry, University of Nairobi, Nairobi, Kenya.
Leonidah O
LO
Kerubo
Department of Chemistry, University of Nairobi, Nairobi, Kenya.
Jacob O
JO
Midiwo
D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification*; D029802:Croton / Q000737:chemistry*; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification*; D056727:Endangered Species; D007630:Kenya; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
D045784:Abietanes; D045785:Diterpenes, Clerodane