An efficient approach to construct benzisothiazol-3(2H)-ones via copper-catalyzed consecutive reaction of 2-halobenzamides and carbon disulfide.
An efficient copper-catalyzed reaction for the synthesis of benzisothiazol-3(2H)-ones has been developed, starting from easily available 2-halobenzamides and carbon disulfide, which gave the corresponding target products in 30-89% yield for 25 examples. The reaction proceeds via a consecutive process with S-C bond and S-N bond formation.
Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, China. chendongyin321@163.com.
Ting
T
Li
Lei
L
Yang
Kaidong
K
Ni
Zhenyu
Z
Shi
Fei
F
Li
Dongyin
D
Chen