Ras signaling through RASSF proteins.
There are six core RASSF family proteins that contain conserved Ras Association domains and may serve as Ras effectors. They lack intrinsic enzymatic activity and appear to function as scaffolding and localization molecules. While initially being associated with pro-apoptotic signaling pathways such as Bax and Hippo, it is now clear that they can also connect Ras to a surprisingly broad range of signaling pathways that control senescence, inflammation, autophagy, DNA repair, ubiquitination and protein acetylation. Moreover, they may be able to impact the activation status of pro-mitogenic Ras effector pathways, such as the Raf pathway. The frequent epigenetic inactivation of RASSF genes in human tumors disconnects Ras from pro-death signaling systems, enhancing Ras driven transformation and metastasis. The best characterized members are RASSF1A and RASSF5 (NORE1A).
Department of Medicine, University of Louisville, KY, 40202, USA.
Howard
H
Donninger
Department of Pharmacoloxy and Toxicology, University of Louisville, KY, 40202, USA.
M Lee
ML
Schmidt
Department of Biochemistry and Molecular Genetics, Molecular Targets Program, J.G Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA.
Jessica
J
Mezzanotte
Department of Biochemistry and Molecular Genetics, Molecular Targets Program, J.G Brown Cancer Center, University of Louisville, Louisville, KY, 40202, USA.
Thibaut
T
Barnoud
Department of Pharmacoloxy and Toxicology, University of Louisville, KY, 40202, USA. Electronic address: gjclar01@louisville.edu.
Geoffrey J
GJ
Clark
D000818:Animals; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D018631:ras Proteins / Q000378:metabolism*
D025521:Tumor Suppressor Proteins; D018631:ras Proteins
Apoptosis; NORE1A; RASSF1A; Ras; Signaling; p53