Chronic Pelvic Inflammation Diminished Ovarian Reserve as Indicated by Serum Anti Mülerrian Hormone.
OBJECTIVE
To explore the potential damaging effect of chronic pelvic inflammation on ovarian reserve.


METHODS
Case-control study.


METHODS
A total of 122 women with bilateral tubal occlusion, diagnosed by hysterosalipingography (HSG) and 217 women with normal fallopians were recruited.


METHODS
Serum anti-Mullerian hormone (AMH), basic follicle-stimulating hormone (FSH), luteining hormone (LH), estradiol (E2), and testosterone (T) were measured; and antral follicle counts (AFCs) were recorded.


RESULTS
Significantly lower level of AMH was observed in women with bilateral tubal occlusion compared to control group [2.62 (2.95) ng/ml vs. 3.37 (3.11) ng/ml, P = 0.03], and the difference remained after adjustment of BMI (Padjust = 0.04). However, no statistical difference was found in the levels of FSH [7.00 (2.16) IU/L vs. 6.74 (2.30) IU/L], LH [4.18 (1.52) IU/L vs. 4.63 (2.52) IU/L], E2 [35.95 (20.40) pg/ml vs. 34.90 (17.85) pg/ml], T [25.07±11.46 ng/dl vs. 24.84±12.75 ng/dl], and AFC [6.00 (4.00) vs. 7.00 (4.00)] between two groups (p>0.05).


CONCLUSIONS
Women with bilateral tubal occlusion showed decreased AMH level, suggesting that chronic pelvic inflammation may diminish ovarian reserve. More caution should be paid when evaluating the detriment of PID on female fertility.
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, 250001, China.|The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.|Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, 250001, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, 250001, China.
Linlin
L
Cui
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, 250001, China.|The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.|Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, 250001, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, 250001, China.
Yan
Y
Sheng
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, 250001, China.|The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.|Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, 250001, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, 250001, China.
Mei
M
Sun
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, 250001, China.|The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.|Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, 250001, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, 250001, China.
Jingmei
J
Hu
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, 250001, China.|The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.|Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, 250001, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, 250001, China.
Yingying
Y
Qin
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, 250001, China.|The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.|Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, 250001, China.|National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, 250001, China.|Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200000, China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, 200000, China.
Zi-Jiang
ZJ
Chen
D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D016022:Case-Control Studies; D059350:Chronic Pain / Q000097:blood* / Q000503:physiopathology; D003251:Constriction, Pathologic / Q000097:blood / Q000150:complications; D004958:Estradiol / Q000097:blood; D005184:Fallopian Tube Diseases / Q000097:blood / Q000150:complications; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D065851:Ovarian Reserve; D000292:Pelvic Inflammatory Disease / Q000097:blood* / Q000150:complications* / Q000503:physiopathology; D016649:Primary Ovarian Insufficiency / Q000097:blood / Q000209:etiology; D012307:Risk Factors; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D004958:Estradiol; D054304:Anti-Mullerian Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone