Hybrid Nanoparticles as Drug Carriers for Controlled Chemotherapy of Cancer.
Rapid developments in materials science and biological mechanisms have greatly boosted the research discoveries of new drug delivery systems. In the past few decades, hundreds of nanoparticle-based drug carriers have been reported almost on a daily basis, in which new materials, structures, and mechanisms are proposed and evaluated. Standing out among the drug carriers, the hybrid nanoparticle systems offer a great opportunity for the optimization and improvement of conventional chemotherapy. By combining several features of functional components, these hybrid nanoparticles have shown excellent promises of improved biosafety, biocompatibility, multifunctionality, biodegradability, and so forth. In this Personal Account, we highlight the recent research advances of some representative hybrid nanoparticles as drug delivery systems and discuss their design strategies and responsive mechanisms for controlled drug delivery.
College of Life Science, Chongqing University, Shapingba District Chongqing, 401331, P. R. China.
Menghuan
M
Li
College of Life Science, Chongqing University, Shapingba District Chongqing, 401331, P. R. China.
Zhong
Z
Luo
Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore.
Yanli
Y
Zhao
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D004337:Drug Carriers; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008027:Light; D008081:Liposomes; D060328:Magnetic Phenomena; D058185:Magnetite Nanoparticles; D053758:Nanoparticles; D010084:Oxidation-Reduction; D000069453:Ultrasonic Waves
D000970:Antineoplastic Agents; D004337:Drug Carriers; D008081:Liposomes; D058185:Magnetite Nanoparticles
cancer; controlled release; drug delivery; nanoparticles; stimuli responsiveness