Does AL amyloidosis have a unique genomic profile? Gene expression profiling meta-analysis and literature overview.
Immunoglobulin light chain amyloidosis (ALA) is a plasma cell dyscrasia characterized by deposition of amyloid fibrils in various organs and tissues. The current paper is devoted to clarify if ALA has a unique gene expression profile and to its pathogenetic argumentation. The meta-analysis of ALA patients vs. healthy donors, monoclonal gammopathy of undetermined significance, smoldering and multiple myeloma patients' cohorts have revealed molecular signature of ALA consists of 256 genes representing mostly ribosomal proteins and immunoglobulin regions. This signature appears pathogenetically supported and elucidates for the first time the role of ribosome dysfunction in ALA. In summary of our findings with literature overview, we hypothesize that ALA development is associated not only with changes in genes, coding amyloidogenic protein itself, but with post-transcriptional disbalance as well. Based on our data analysis in ALA, ribosome machinery is impaired and the affected link mainly involves translational initiation, elongation and co-translational protein folding.
Department of Haematooncology, Faculty of Medicine, University of Ostrava, Czech Republic; Department of Haematooncology, University Hospital Ostrava, Czech Republic. Electronic address: f.kryukov@gmail.com.
Fedor
F
Kryukov
Department of Haematooncology, Faculty of Medicine, University of Ostrava, Czech Republic; Department of Haematooncology, University Hospital Ostrava, Czech Republic.
Elena
E
Kryukova
Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Lucie
L
Brozova
Department of Haematooncology, Faculty of Medicine, University of Ostrava, Czech Republic; Department of Haematooncology, University Hospital Ostrava, Czech Republic.
Zuzana
Z
Kufova
Department of Haematooncology, Faculty of Medicine, University of Ostrava, Czech Republic.
Jana
J
Filipova
Department of Haematooncology, Faculty of Medicine, University of Ostrava, Czech Republic.
Katerina
K
Growkova
Department of Haematooncology, Faculty of Medicine, University of Ostrava, Czech Republic; Department of Haematooncology, University Hospital Ostrava, Czech Republic.
Tereza
T
Sevcikova
Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Jiri
J
Jarkovsky
Department of Haematooncology, Faculty of Medicine, University of Ostrava, Czech Republic; Department of Haematooncology, University Hospital Ostrava, Czech Republic.
Roman
R
Hajek
D000686:Amyloidosis / Q000235:genetics*; D000818:Animals; D020869:Gene Expression Profiling; D050439:Genes, Immunoglobulin Light Chain; D006801:Humans; D010265:Paraproteinemias / Q000235:genetics*
AL amyloidosis; Gene expression profile; Meta-analysis; Monoclonal gammapaties; Ribosome