Multifocal Lymphangioendotheliomatosis with Thrombocytopenia: Presentation of Two Cases Treated with Sirolimus.
Multifocal lymphangioendotheliomatosis with thrombocytopenia (MLT) is a rare disease characterized by congenital and progressive vascular lesions of the skin and gastrointestinal tract that may be associated with thrombocytopenia and possibly life-threatening gastrointestinal bleeding. Reports published on the disease and treatment strategies are scarce. We present two cases of MLT treated with sirolimus.
Department of Dermatology, Hospital de Pediatría "Prof. Dr. Juan. P. Garrahan", Buenos Aires, Argentina.
Agustina
A
Lanöel
Department of Dermatology, Hospital de Pediatría "Prof. Dr. Juan. P. Garrahan", Buenos Aires, Argentina.
Adriana Natalia
AN
Torres Huamani
Department of Hematology, Hospital de Pediatría "Prof. Dr. Juan. P. Garrahan", Buenos Aires, Argentina.
Aurora
A
Feliú
Department of Pathology, Hospital de Pediatría "Prof. Dr. Juan. P. Garrahan", Buenos Aires, Argentina.
María Josefina
MJ
Sala
Department of Pathology, Hospital de Pediatría "Prof. Dr. Juan. P. Garrahan", Buenos Aires, Argentina.
Mariana
M
Alvarez
Department of Dermatology, Hospital de Pediatría "Prof. Dr. Juan. P. Garrahan", Buenos Aires, Argentina.
Andrea Bettina
AB
Cervini
D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D007223:Infant; D008202:Lymphangioma / Q000150:complications / Q000188:drug therapy*; D020123:Sirolimus / Q000627:therapeutic use*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D013921:Thrombocytopenia / Q000150:complications / Q000188:drug therapy*
D000903:Antibiotics, Antineoplastic; D020123:Sirolimus