Neuro-Modulation of Immuno-Endocrine Response Induced by Kaliotoxin of Androctonus Scorpion Venom.
Kaliotoxin (KTX), a specific blocker of potassium channels, exerts various toxic effects due to its action on the central nervous system. Its use in experimental model could help the understanding of the cellular and molecular mechanisms involved in the neuropathological processes related to potassium channel dysfunctions. In this study, the ability of KTX to stimulate neuro-immuno-endocrine axis was investigated. As results, the intracerebroventricular injection of KTX leads to severe structural-functional alterations of both hypothalamus and thyroid. These alterations were characterized by a massive release of hormones' markers of thyroid function associated with damaged tissue which was infiltrated by inflammatory cell and an imbalanced redox status. Taken together, these data highlight that KTX is able to modulate the neuro-endocrine response after binding to its targets leading to the hypothalamus and the thyroid stimulation, probably by inflammatory response activation and the installation of oxidative stress in these organs.
USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene, Algiers, Algeria.
Amina
A
Ladjel-Mendil
CNRS UMR 7286 CRN2M, Institut Fédératif de Recherche Jean Roche, Faculté de Médecine Nord, Aix-Marseille University, Marseille, France.
Marie-France
MF
Martin-Eauclaire
USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene, Algiers, Algeria.
Fatima
F
Laraba-Djebari
D000818:Animals; D002116:Calcitonin / Q000096:biosynthesis / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D004804:Eosinophils / Q000187:drug effects* / Q000276:immunology; D005978:Glutathione / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D007276:Injections, Intraventricular; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D020556:Neutrophil Infiltration / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D009570:Nitriles / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D012604:Scorpion Venoms / Q000302:isolation & purification / Q000633:toxicity*; D012605:Scorpions / Q000737:chemistry* / Q000502:physiology; D013961:Thyroid Gland / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D013972:Thyrotropin / Q000096:biosynthesis / Q000378:metabolism; D013974:Thyroxine / Q000096:biosynthesis / Q000378:metabolism; D014284:Triiodothyronine / Q000096:biosynthesis / Q000378:metabolism
D009570:Nitriles; D012604:Scorpion Venoms; C072276:kaliotoxin; D014284:Triiodothyronine; D008315:Malondialdehyde; D013972:Thyrotropin; D002116:Calcitonin; D002374:Catalase; D005978:Glutathione; D013974:Thyroxine
Hormone Release; Inflammation; Kaliotoxin; Oxidative Stress