Precision Nanomedicine Using Dual PET and MR Temperature Imaging-Guided Photothermal Therapy.
Imaging-based techniques have enabled the direct integration of noninvasive imaging with minimally invasive interventions such as photothermal therapy (PTT) to improve the precision of treatment.


METHODS
We investigated the feasibility of PTT for ovarian cancer under the guidance of PET and MR temperature imaging using copper sulfide nanoparticles (CuS NPs). The tumor distribution of the CuS NPs after systemic administration was assessed using highly sensitive, quantifiable PET imaging. Two wavelengths of near-infrared (NIR) lasers-808 and 980 nm-were tested for PTT using noninvasive MR temperature imaging real-time monitoring.


RESULTS
The in vivo studies revealed that the 980-nm NIR laser had better photothermal effects than the 808-nm NIR laser. These results were in accord with the histologic findings. In vivo PTT using CuS NPs combined with 980-nm laser irradiation achieved significant tumor ablation compared with no treatment control in both subcutaneous (P = 0.007) and orthotopic (P < 0.001) models of ovarian cancer with regard to the percentage of necrotic damage.


CONCLUSIONS
Our results indicate that real-time monitoring of the accuracy of PTT is a promising approach for future clinical translation of this emerging thermal ablation technique.
Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas.|Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.|Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, China.
Min
M
Zhou
Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Marites
M
Melancon
Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
R Jason
RJ
Stafford
Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Junjie
J
Li
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; and.
Alpa M
AM
Nick
Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Mei
M
Tian
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; and.|Center for RNAi and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Anil K
AK
Sood
Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas cli@mdanderson.org.
Chun
C
Li
D000818:Animals; D045744:Cell Line, Tumor; D003300:Copper; D003301:Copper Radioisotopes; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D028022:Low-Level Light Therapy / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053768:Metal Nanoparticles; D051379:Mice; D008819:Mice, Nude; D064847:Multimodal Imaging / Q000379:methods; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D049268:Positron-Emission Tomography / Q000379:methods*; D057285:Precision Medicine / Q000379:methods; D019275:Radiopharmaceuticals; D013817:Thermography / Q000379:methods*
D003301:Copper Radioisotopes; D019275:Radiopharmaceuticals; D003300:Copper
CuS nanoparticles; MRI; PET; ovarian cancer; photothermal therapy