Impact of aortocaval shunt flow on cardiac and renal function in unilateral nephrectomized rats.
We previously reported significantly enhanced cardiac remodeling post aortocaval fistula (AV) in unilateral nephrectomized (UNX) rats. However, the relationship between the size of the AV and the cardiorenal effects in UNX rats remains unknown. In the present study, AV was induced by 20, 18 and 16 gauge needles in UNX rats to see if larger shunt would definitely induce heavier cardiac and renal damage in UNX rats. Our results demonstrated that bigger shunt size is linked with proportional more significant cardiorenal remodeling and dysfunction in UNX rats. Expression of inflammatory biomarkers including CRP, TNF-α, IL-6, IL-1β, TGF-β and MCP-1 in left kidney and heart was significantly increased in all UNX + AV groups compared to Sham rats. Inflammation might thus participate in the worsening cardiorenal functions and remodeling processes in this model.
Department of Cardiology, Puai Hospital, Jianghan University, Wuhan, 430033, China.
Jie
J
Wu
Department of Cardiology, Puai Hospital, Jianghan University, Wuhan, 430033, China.
Zhong
Z
Cheng
Department of Cardiology, Puai Hospital, Jianghan University, Wuhan, 430033, China.
Mingjing
M
Zhang
Department of Cardiology, Puai Hospital, Jianghan University, Wuhan, 430033, China.
Pengfei
P
Zhu
Department of Cardiology, Puai Hospital, Jianghan University, Wuhan, 430033, China.
Ye
Y
Gu
D000818:Animals; D001011:Aorta / Q000503:physiopathology*; D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology*; D015415:Biomarkers / Q000378:metabolism; D005402:Fistula / Q000503:physiopathology; D006321:Heart / Q000503:physiopathology*; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009392:Nephrectomy / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley
D015415:Biomarkers