Renal thrombotic microangiopathy and FIP1L1/PDGFRα-associated myeloproliferative variant of hypereosinophilic syndrome.
We report a case of renal thrombotic microangiopathy (TMA) in a myeloproliferative variant of hypereosinophilic syndrome (HES) in a 24-year-old man which resolved with imatinib therapy. This is one of a few cases in the literature to date describing TMA in HES, suggesting that the pathogenesis of thrombosis is at least in part related to damage from activated eosinophils.
Department of Nephrology , Pitie Salpetriere Hospital , Paris , France.
Anne Lyse
AL
Langlois
Department of Nephrology , Pitie Salpetriere Hospital , Paris , France.
Nathalie
N
Shehwaro
Department of Internal Medicine, School of Medicine, Department of General Practice , Saint Antoine Hospital, UPMC University Paris 06 , Paris , France.
Claire
C
Rondet
Department of Nephrology , Pitie Salpetriere Hospital , Paris , France.
Youssef
Y
Benbrik
Department of Haematology , Pitie Salpetriere Hospital , Paris , France.
Karim
K
Maloum
Department of Nephrology , Pitie Salpetriere Hospital , Paris , France.
Victor
V
Gueutin
Department of Pathology , Pitie Salpetriere Hospital , Paris , France.
Philippe
P
Rouvier
Department of Nephrology , Pitie Salpetriere Hospital , Paris , France.
Hassane
H
Izzedine
hypereosinophilic syndrome; imatinib; thrombotic microangiopathy