Calcium dependent plasticity applied to repetitive transcranial magnetic stimulation with a neural field model.
The calcium dependent plasticity (CaDP) approach to the modeling of synaptic weight change is applied using a neural field approach to realistic repetitive transcranial magnetic stimulation (rTMS) protocols. A spatially-symmetric nonlinear neural field model consisting of populations of excitatory and inhibitory neurons is used. The plasticity between excitatory cell populations is then evaluated using a CaDP approach that incorporates metaplasticity. The direction and size of the plasticity (potentiation or depression) depends on both the amplitude of stimulation and duration of the protocol. The breaks in the inhibitory theta-burst stimulation protocol are crucial to ensuring that the stimulation bursts are potentiating in nature. Tuning the parameters of a spike-timing dependent plasticity (STDP) window with a Monte Carlo approach to maximize agreement between STDP predictions and the CaDP results reproduces a realistically-shaped window with two regions of depression in agreement with the existing literature. Developing understanding of how TMS interacts with cells at a network level may be important for future investigation.
School of Engineering, Faculty of Science and Engineering, University of Waikato, Private Bag 3105, Hamilton, 3240, New Zealand. mtwilson@waikato.ac.nz.
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MT
Wilson
Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, NY, 11203, U.S.A.
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PK
Fung
School of Physics, University of Sydney, Sydney, NSW, 2006, Australia.|Center for Integrative Brain Function, University of Sydney, Sydney, NSW, 2006, Australia.|Center for Research Excellence, NeuroSleep, 431 Glebe Point Road, Glebe, NSW, 2037, Australia.
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PA
Robinson
School of Physical Education, Brain Health Research Centre, University of Otago, P.O. Box 56, Dunedin, 9054, New Zealand.
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J
Shemmell
Department of Anatomy, Brain Health Research Centre, University of Otago School of Medical Sciences, P.O. Box 913, Dunedin, 9054, New Zealand.
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Reynolds
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation
D002118:Calcium
Calcium dependent plasticity; Modeling; Neural field theory; Theta burst stimulation; Transcranial magnetic stimulation