Chromosome Microarray.
Over the last half century, knowledge about genetics, genetic testing, and its complexity has flourished. Completion of the Human Genome Project provided a foundation upon which the accuracy of genetics, genomics, and integration of bioinformatics knowledge and testing has grown exponentially. What is lagging, however, are efforts to reach and engage nurses about this rapidly changing field. The purpose of this article is to familiarize nurses with several frequently ordered genetic tests including chromosomes and fluorescence in situ hybridization followed by a comprehensive review of chromosome microarray. It shares the complexity of microarray including how testing is performed and results analyzed. A case report demonstrates how this technology is applied in clinical practice and reveals benefits and limitations of this scientific and bioinformatics genetic technology. Clinical implications for maternal-child nurses across practice levels are discussed.
Sharon Anderson is Assistant Professor and Co-Director of the RN to BS in Nursing Program at Rutgers, The State University of New Jersey, Newark, NJ. She is also an Advanced Practice Nurse in Genetics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ. The author can be reached via e-mail at sharon.anderson@rutgers.edu.
Sharon
S
Anderson
D000013:Congenital Abnormalities / Q000175:diagnosis / Q000235:genetics; D005817:Genetic Counseling; D005820:Genetic Testing / Q000639:trends*; D016045:Human Genome Project; D006801:Humans; D046228:Microarray Analysis / Q000379:methods* / Q000639:trends; D025202:Molecular Diagnostic Techniques / Q000379:methods