Laryngeal chondrosarcoma: A systematic review of 592 cases.
Laryngeal chondrosarcomas are rare entities that arise from the cartilaginous structures of the larynx, including the cricoid, thyroid cartilage, epiglottis, and arytenoid cartilages. These tumors represent a minority of malignancies involving the larynx and can be mistaken for benign pathologies. The treatment has historically been surgical excision, often by total laryngectomy. This review investigates treatment modalities and patient outcomes.



Systematic review using PubMed/MEDLINE and EMBASE database.



The databases were used to identify articles reporting cases of chondrosarcomas occurring exclusively in the larynx. Variables analyzed included patient demographics, presenting symptoms, grade, therapeutic approach, patient outcomes, and follow-up.



Five hundred and ninety-two cases were identified. The average age reported was 62.5 years. There was a 3:1 male to female ratio. The most common surgical approach was local excision in 178 cases, followed by total laryngectomy in 174 cases. Nonsurgical treatment such as radiotherapy and chemotherapy was only used in 0.8% and 0.2%, respectively. Disease-specific survival rates for 1, 5, 10, and 20 years were 97.7%, 91.4%, 81.8%, and 68.0%, respectively, with no differences when comparing 5-year survival rates for location, grade, and therapy.



Laryngeal chondrosarcomas are rare with a good prognosis. Various surgical approaches exist, with no difference noted in 5-year survival outcomes. Nonsurgical approaches were rarely used for these lesions.



N/A. Laryngoscope, 2016 127:430-439, 2017.
Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, U.S.A.
Oliver Y
OY
Chin
Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, U.S.A.
Pariket M
PM
Dubal
Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, U.S.A.
Ahmed B
AB
Sheikh
Department of Otolaryngology and Facial Plastic Surgery, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, U.S.A.
Aykut A
AA
Unsal
Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, U.S.A.
Richard Chan Woo
RC
Park
Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, U.S.A.|Center for Skull Base and Pituitary Surgery, Rutgers New Jersey Medical School, Newark, U.S.A.
Soly
S
Baredes
Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, U.S.A.|Center for Skull Base and Pituitary Surgery, Rutgers New Jersey Medical School, Newark, U.S.A.|Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, U.S.A.|Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, U.S.A.
Jean Anderson
JA
Eloy
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002813:Chondrosarcoma / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007817:Laryngeal Cartilages / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D055815:Young Adult
Larynx chondrosarcoma; cartilaginous tumor; chondrosarcomas; laryngeal cancer; laryngeal chondrosarcoma; laryngeal malignancy; laryngeal tumor; larynx cancer; larynx malignancy; systematic review