Initial Results of Hypofractionated Carbon Ion Radiotherapy for Cholangiocarcinoma.
OBJECTIVE
To report initial results of hypofractionated carbon ion radiotherapy (C-ion RT) for cholangiocarcinoma.


METHODS
Data regarding seven patients with cholangiocarcinoma treated by C-ion RT were analyzed. Prescribed doses were 52.8 Gy [relative biological effectiveness (RBE)] or 60.0 Gy (RBE) in four fractions for intrahepatic cases and 12 fractions for hilar hepatic/close to gastro-intestinal tract cases. Local control and overall survival were evaluated and toxicity was graded using Common Terminology Criteria for Adverse Events, version 4.0.


RESULTS
The median follow-up period was 16 months. There were two patients with stage I cancer, one with stage II, one with stage III, and three with stage IVA. Local control was achieved in five out of seven patients (71%) and survival was maintained in six out of seven patients (86%). There were no occurrences of acute or late toxicity of grade 3 or higher.


CONCLUSIONS
Initial results show that hypofractionated C-ion RT appears to be tolerated and effective for cholangiocarcinoma.
Department of Radiation Oncology, Gunma University, Graduate School of Medicine, Maebashi, Japan mrtaka100@yahoo.co.jp.
Takanori
T
Abe
Department of Radiation Oncology, Gunma University, Graduate School of Medicine, Maebashi, Japan.
Kei
K
Shibuya
Department of Diagnostic and Interventional Radiology, Gunma University, Graduate School of Medicine, Maebashi, Japan.
Yoshinori
Y
Koyama
Gunma University Heavy Ion Medical Center, Maebashi, Japan.
Masahiko
M
Okamoto
Gunma University Heavy Ion Medical Center, Maebashi, Japan.
Hiroki
H
Kiyohara
Gunma University Heavy Ion Medical Center, Maebashi, Japan.
Hiroyuki
H
Katoh
Gunma University Heavy Ion Medical Center, Maebashi, Japan.
Hirohumi
H
Shimada
General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Japan.
Hiroyuki
H
Kuwano
General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Japan.
Tatsuya
T
Ohno
Department of Radiation Oncology, Gunma University, Graduate School of Medicine, Maebashi, Japan.
Takashi
T
Nakano
D000368:Aged; D001650:Bile Duct Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D018281:Cholangiocarcinoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D063193:Heavy Ion Radiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
Carbon ion radiotherapy; cholangiocarcinoma; local control