Modulation of Cardiac Potassium Current by Neural Tone and Ischemia.
The cardiac action potential is generated by intricate flows of ions across myocyte cell membranes in a coordinated fashion to control myocardial contraction and the heart rhythm. Modulation of the flow of these ions in response to a variety of stimuli results in changes to the action potential. Abnormal or altered ion currents can result in cardiac arrhythmias. Abnormalities of autonomic regulation of potassium current play a role in the genesis of cardiac arrhythmias, and alterations in acetylcholine-activated potassium channels may play a key role in atrial fibrillation. Ischemia is another important modulator of cardiac cellular electrophysiology.
Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Todd T
TT
Tomson
Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: r-arora@northwestern.edu.
Rishi
R
Arora
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D001341:Autonomic Nervous System / Q000502:physiology*; D054849:Cardiac Electrophysiology; D004285:Dogs; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D051379:Mice; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015221:Potassium Channels / Q000502:physiology*
D015221:Potassium Channels
ATP-sensitive potassium channel; Acetylcholine-activated potassium channel; Atrial fibrillation; Autonomic nervous system; Cardiac arrhythmias; Potassium channels