Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia.
Rannasangpei (RSNP) is used as a therapeutic agent in the treatment of cardiovascular diseases, neurological disorders, and neurodegeneration in China; however, its potential use in the treatment of vascular dementia (VD) was unclear. In this study, our aim was to examine the neuroprotective effect of RSNP in a VD rat model, which was induced by permanent bilateral common carotid artery occlusion (2VO). Four-week administration with two doses of RSNP was investigated in our study. Severe cognitive deficit in the VD model, which was confirmed in Morris water maze (MWM) test, was significantly restored by the administration of RSNP. ELISA revealed that the treatments with both doses of RSNP could reinstate the cholinergic activity in the VD animals by elevating the production of choline acetyltransferase (ChAT) and reducing the acetylcholinesterase (AChE); the treatment of RSNP could also reboot the level of superoxide dismutase (SOD) and decrease malondialdehyde (MDA). Moreover, Western blot and quantitative PCR (Q-PCR) results indicated that the RSNP could suppress the apoptosis in the hippocampus of the VD animals by increasing the expression ratio of B-cell lymphoma-2 (Bcl-2) to Bcl-2-associated X protein (Bax). These results suggested that RSNP might be a therapeutic agent in the treatment of vascular dementia in the future.
Southern Medical University, Guangzhou 510515, China; Beijing Tibetan Hospital, China Tibetology Research Center, Beijing 100029, China.
Peng
P
Wu
Beijing Tibetan Hospital, China Tibetology Research Center, Beijing 100029, China.
Yuandai
Y
Luo
Beijing Tibetan Hospital, China Tibetology Research Center, Beijing 100029, China.
Lifang
L
Zhen
Beijing Tibetan Hospital, China Tibetology Research Center, Beijing 100029, China.
Xianda
X
Hu
Beijing Mentougou Hospital of Traditional Chinese Medicine, Beijing 102300, China.
Ying
Y
Shang
Southern Medical University, Guangzhou 510515, China.
Yinuo
Y
Liao
Southern Medical University, Guangzhou 510515, China.
Huiyuan
H
Xue
Beijing Tibetan Hospital, China Tibetology Research Center, Beijing 100029, China.
Fukai
F
Huang
Southern Medical University, Guangzhou 510515, China.
Wei
W
Xiao