Local field potential oscillations of the globus pallidus in cervical and tardive dystonia.
BACKGROUND
Reports about neural oscillatory activity in the globus pallidus internus (GPi) have targeted general (GD) and cervical dystonia (CD), however to our knowledge they are nonexistent for tardive dystonia (TD).


METHODS
Local field potentials (LFPs) from seven CD and five TD patients were recorded intraoperatively. We compared LFP power in thetadelta, alpha and beta band during rest and sensory palmar stimulation (SPS) in patients with general anesthesia and local/analgo sedation.


RESULTS
We found prominent LFP power activity in thetadelta for both CD and TD. Unlike TD, a significant difference between rest and SPS was revealed for CD.


CONCLUSIONS
Our data support the presence of LFP oscillatory activity in CD and TD. Thetadelta power modulation in the GPi is suggested as a signature for sensory processing in CD.
Heinrich Heine University, Medical Faculty, Institute of Clinical Neuroscience and Medical Psychology, Duesseldorf, Germany; Heinrich Heine University, Medical Faculty, Department of Neurology, Center for Movement Disorders and Neuromodulation, Duesseldorf, Germany.
Carlos
C
Trenado
Heinrich Heine University, Medical Faculty, Institute of Clinical Neuroscience and Medical Psychology, Duesseldorf, Germany; Heinrich Heine University, Medical Faculty, Department of Neurology, Center for Movement Disorders and Neuromodulation, Duesseldorf, Germany.
Christian J
CJ
Hartmann
Heinrich Heine University, Medical Faculty, Institute of Clinical Neuroscience and Medical Psychology, Duesseldorf, Germany.
Saskia
S
Elben
University Cologne, Department of Neurology, Cologne, Germany.
K Amande M
KAM
Pauls
Heinrich Heine University, Medical Faculty, Institute of Clinical Neuroscience and Medical Psychology, Duesseldorf, Germany.
Lena
L
Friggemann
Heinrich Heine University, Medical Faculty, Institute of Clinical Neuroscience and Medical Psychology, Duesseldorf, Germany; Heinrich Heine University, Medical Faculty, Department of Neurology, Center for Movement Disorders and Neuromodulation, Duesseldorf, Germany.
Stefan Jun
SJ
Groiss
University Cologne, Department of Neurology, Cologne, Germany.
Lars
L
Timmermann
Heinrich Heine University, Medical Faculty, Department of Functional and Stereotactic Neurosurgery, Center for Movement Disorders and Neuromodulation, Duesseldorf, Germany.
Jan
J
Vesper
Heinrich Heine University, Medical Faculty, Institute of Clinical Neuroscience and Medical Psychology, Duesseldorf, Germany; Heinrich Heine University, Medical Faculty, Department of Neurology, Center for Movement Disorders and Neuromodulation, Duesseldorf, Germany.
Alfons
A
Schnitzler
Heinrich Heine University, Medical Faculty, Institute of Clinical Neuroscience and Medical Psychology, Duesseldorf, Germany; Heinrich Heine University, Medical Faculty, Department of Neurology, Center for Movement Disorders and Neuromodulation, Duesseldorf, Germany. Electronic address: wojtecki@uni-duesseldorf.de.
Lars
L
Wojtecki
D000328:Adult; D000368:Aged; D058256:Brain Waves; D046690:Deep Brain Stimulation; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D058542:Implantable Neurostimulators; D064795:Intraoperative Neurophysiological Monitoring; D008297:Male; D008875:Middle Aged; D000071057:Tardive Dyskinesia / Q000503:physiopathology* / Q000601:surgery; D014103:Torticollis / Q000503:physiopathology* / Q000601:surgery
Cervical and tardive dystonia; Globus pallidus; Intraoperative recordings; Local field potentials; Oscillations