Ketamine-Midazolam Anesthesia Induces Total Inhibition of Cortical Activity in the Brain of Newborn Rats.
The effects of general anesthetics ketamine and midazolam, the drugs that cause neuroapoptosis at the early stages of CNS development, on electrical activity of the somatosensory cortex in newborn rats were studied using extracellular recording of local field potentials and action potentials of cortical neurons. Combined administration of ketamine (40 mg/kg) and midazolam (9 mg/kg) induced surgical coma and almost completely suppressed early oscillatory patterns and neuronal firing. These effects persisted over 3 h after injection of the anesthetics. We concluded that general anesthesia induced by combined administration of ketamine and midazolam profoundly suppressed cortical activity in newborn rats, which can trigger neuroapoptosis in the developing brain.
Kazan (Volga Region) Federal University, Kazan, Russia.|Mediterranean Institute of Neurobiology (INMED), Marseille, France.
Yu A
YA
Lebedeva
Kazan (Volga Region) Federal University, Kazan, Russia.|Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Tatarstan Republic, Russia.
A V
AV
Zakharova
Kazan (Volga Region) Federal University, Kazan, Russia.
G F
GF
Sitdikova
Kazan State Medical University, Ministry of Health of the Russian Federation, Kazan, Tatarstan Republic, Russia.
A L
AL
Zefirov
Kazan (Volga Region) Federal University, Kazan, Russia. roustem.khazipov@inserm.fr.|Mediterranean Institute of Neurobiology (INMED), Marseille, France. roustem.khazipov@inserm.fr.|Aix-Marseille University, Marseille, France. roustem.khazipov@inserm.fr.
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Khazipov
D000777:Anesthetics / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects*; D007649:Ketamine / Q000008:administration & dosage* / Q000009:adverse effects*; D008874:Midazolam / Q000008:administration & dosage* / Q000009:adverse effects*; D051381:Rats; D013003:Somatosensory Cortex / Q000187:drug effects
D000777:Anesthetics; D007649:Ketamine; D008874:Midazolam
EEG; anesthesia; newborn; somatosensory cortex