A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature.
Uveal melanoma is a rare subtype of melanoma, accounting for only 3-5% of all melanoma cases in the USA. Although fewer than 4% of uveal melanoma patients present with metastasis at diagnosis, approximately half will develop metastasis, more than 90% of which disseminate to the liver. Infrequently, a number of malignancies can lead to leptomeningeal metastases, a devastating and terminal complication. In this case report, we present an exceedingly rare case of a patient with uveal melanoma who developed leptomeningeal carcinomatosis as the sole site of metastasis. After conventional methods to diagnose leptomeningeal carcinomatosis fell short, a diagnosis was confirmed on the basis of identification and genomic analysis of melanoma circulating tumor cells in the cerebrospinal fluid.
Departments of aTumor Biology bNeurooncology cAnatomic Pathology dCutaneous Oncology eMorsani Molecular Diagnostics Laboratory, Moffitt Cancer Center & Research Institute, Tampa fBascom Palmer Eye Institute, Sylvester Comprehensive Cancer Center and Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida, USA gDepartment of Oncology, Tom Baker Cancer Center & University of Calgary, Calgary, Alberta, Canada.
Inna V
IV
Fedorenko
Brittany
B
Evernden
Rajappa S
RS
Kenchappa
Solmaz
S
Sahebjam
Elena
E
Ryzhova
John
J
Puskas
Linda
L
McIntosh
Gisela
G
Caceres
Anthony
A
Magliocco
Arnold
A
Etame
J William
JW
Harbour
Keiran S M
KS
Smalley
Peter A
PA
Forsyth
D005260:Female; D006801:Humans; D008545:Melanoma / Q000150:complications* / Q000473:pathology; D055756:Meningeal Carcinomatosis / Q000209:etiology*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology; D014604:Uveal Neoplasms / Q000150:complications* / Q000473:pathology; D000098943:Uveal Melanoma