Stereotactic radiosurgery as a feasible treatment for intramedullary spinal arteriovenous malformations: a single-center observation.
Spinal cord intramedullary arteriovenous malformations are rare. For patients suffering from either hemorrhage or myelopathy, surgical or endovascular interventions are indicated. However, complete eradication of the nidus is often difficult because of its intramedullary location and complex angioarchitecture. In this report, we evaluate the feasibility and safety of stereotactic radiosurgery as a treatment modality for intramedullary spinal arteriovenous malformations (AVMs). Between 2010 and 2014, we performed stereotactic radiosurgery to treat four patients with intramedullary AVM and one with spinal arteriovenous metameric syndrome (one woman and four men; age range, 31-66 years). Three patients presented with myelopathy, and two suffered hemorrhages. Nidi were located in the cervical (three cases) and thoracic (two cases) spinal cord regions. Based on the angioarchitecture, surgery and endovascular embolization were indicated. When both modalities were deemed hazardous, radiosurgery using CyberKnife™ was offered. Radiation using marginal doses of 18 Gy was administered in three fractions. The mean follow-up period was 37.2 months (range, 16-62 months). After treatment, two of the three patients with myelopathy experienced either improvement or stabilization of their symptoms and one experienced worsening of dysesthesia. In two patients with hemorrhage, symptoms improved in one and remained stable in the other. No further hemorrhagic episodes were evident during follow-up. Follow-up angiograms showed marked shrinkage of the nidus located in the thoracic spinal cord in one case and angiographic stabilization in the others. As a treatment modality for intramedullary AVMs, CyberKnife™ is safe and can be considered when surgery or endovascular therapy is not indicated. To determine optimum radiation doses and protocols for treating spinal AVMs, further studies with more patients and long-term follow-up are required.
Department of Neurosurgery, Graduate School of Medicine, Tohoku University, 1-1 Seiryo Aoba, Sendai, 980-8574, Japan.
Sherif
S
Rashad
Department of Neurosurgery, Graduate School of Medicine, Tohoku University, 1-1 Seiryo Aoba, Sendai, 980-8574, Japan. endo@nsg.med.tohoku.ac.jp.
Toshiki
T
Endo
Sendai Radiation Oncology and Imaging Clinic, Sendai, Japan.
Yoshihiro
Y
Ogawa
Department of Neuroendovascular Therapy, Kohnan Hospital, Sendai, Japan.
Kenichi
K
Sato
Department of Neurosurgery, Graduate School of Medicine, Tohoku University, 1-1 Seiryo Aoba, Sendai, 980-8574, Japan.
Hidenori
H
Endo
Department of Neuroendovascular Therapy, Kohnan Hospital, Sendai, Japan.
Yasushi
Y
Matsumoto
Department of Neuroendovascular Therapy, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Akira
A
Takahashi
Department of Neurosurgery, Graduate School of Medicine, Tohoku University, 1-1 Seiryo Aoba, Sendai, 980-8574, Japan.
Teiji
T
Tominaga
D000328:Adult; D000368:Aged; D001165:Arteriovenous Malformations / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery; D012189:Retrospective Studies; D013116:Spinal Cord / Q000002:abnormalities / Q000098:blood supply; D013118:Spinal Cord Diseases / Q000601:surgery*; D016896:Treatment Outcome
Arteriovenous malformation; CyberKnife; Intramedullary; Myelopathy; Spinal cord