Markedly Improved Glycemic Control in Poorly Controlled Type 2 Diabetes following Direct Acting Antiviral Treatment of Genotype 1 Hepatitis C.
Type 2 diabetes mellitus (T2DM) is often associated with hepatitis C virus (HCV) infection. Successful HCV treatment may improve glycemic control and potentially induce remission of T2DM. We report a case of an obese 52-year-old woman with mixed genotype 1a/1b HCV infection with compensated cirrhosis and a 10-year history of poorly controlled T2DM on insulin therapy. Following successful therapy with sofosbuvir, simeprevir, and ribavirin, her insulin requirements decreased and her glycosylated hemoglobin (HgA1c) normalized despite weight gain. This case suggests an association between HCV and T2DM and the potential for significant improvement in glycemic control with eradication of HCV.
Department of Medicine, NewYork-Presbyterian Hospital, 505 East 70th Street, Suite 450, New York, NY 10021, USA.
Raymond Anthony
RA
Pashun
Department of Medicine, NewYork-Presbyterian Hospital, 505 East 70th Street, Suite 450, New York, NY 10021, USA.
Nicole T
NT
Shen
Division of Gastroenterology and Hepatology, NewYork-Presbyterian Hospital, Weill Cornell Medical College, 1305 York Avenue, 4th Floor, New York, NY 10021, USA.
Arun
A
Jesudian