Paramagnetic lanthanide chelates for multicontrast MRI.
The preparation of a paramagnetic chelator that serves as a platform for multicontrast MRI, and can be utilized either as a T1-weighted, paraCEST or (19)F MRI contrast agent is reported. Its europium(iii) complex exhibits an extremely slow water exchange rate which is optimal for the use in CEST MRI. The potential of this platform was demonstrated through a series of MRI studies on tube phantoms and animals.
MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany. goran.angelovski@tuebingen.mpg.de.
Nevenka
N
Cakić
Tanja
T
Savić
Janice
J
Stricker-Shaver
Vincent
V
Truffault
Carlos
C
Platas-Iglesias
Christian
C
Mirkes
Rolf
R
Pohmann
Klaus
K
Scheffler
Goran
G
Angelovski