Use of a Non-cross-linked Xenograft (Xenform) in Surgical Treatment of Peyronie's Disease.
OBJECTIVE
To evaluate the effectiveness in Peyronie's disease surgical treatment using Xenform, a non-cross-linked graft derived from dermal bovine tissue, to close the defect obtained after plaque incision, without penile prosthesis implant. A further objective is to evaluate the satisfaction of patients.


METHODS
We treated with plaque incision 28 patients with a stable penile curvature ≥60° hindering penetration and with erectile function conserved. International Index of Erectile Function-15 and a not-validated questionnaire constituted of 7 questions about their satisfaction were administered after 1 year of follow-up. Furthermore, specific questions were relative about penile straightening, penile postoperative length, glandular sensitivity, and feeling palpability.


RESULTS
Graft is resulted compatible with albugineal features, like thickness, consistency, and elasticity; it is waterproof, allowing the visualization of complete correction of the curvature after the suture. No severe complications were observed except 1 hematoma requiring surgical revision. Sixteen patients were seen after at least 1 year of follow-up. Curvature improvement was obtained in all cases, with the complete straightening in 75%; we did not observe any retraction of the graft and any recurrence on the curvature. Significant reduced glans sensibility and erectile dysfunction were the more frequent postoperative complications, resulting in 43.8% and 25%, respectively. All patients are satisfied with the straightening. Only 2 patients are dissatisfied about the overall result.


CONCLUSIONS
Plaque incision corporoplasty with Xenform graft is an effective and safe surgical treatment. Xenform is a secure and a reliable albugineal substitute, comparable to other heterologous graft. We have not observed any retraction. Patient's satisfaction is linked to the treatment result and to sexual life.
Urology Operative Unit, Civitanova Marche Hospital, Area Vasta 3 Asur Marche, Civitanova Marche, Italy.
Enrico
E
Caraceni
Marche Polytechnic University, Ancona, Italy. Electronic address: luca.leone.1985@gmail.com.
Luca
L
Leone
Urology Operative Unit, Civitanova Marche Hospital, Area Vasta 3 Asur Marche, Civitanova Marche, Italy.
Lilia
L
Utizi
Urology Operative Unit, Civitanova Marche Hospital, Area Vasta 3 Asur Marche, Civitanova Marche, Italy.
Angelo
A
Marronaro
D000368:Aged; D000818:Animals; D002417:Cattle; D003094:Collagen; D064593:Heterografts; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010411:Penile Induration / Q000601:surgery*; D014183:Transplantation, Heterologous; D013521:Urologic Surgical Procedures, Male / Q000379:methods
D003094:Collagen