The association analysis polymorphism of CDKAL1 and diabetic retinopathy in Chinese Han population.
OBJECTIVE
To identify the contribution of CDKAL1 to the development of diabetic retinopathy (DR) in Chinese population.


METHODS
A case-control study was performed to investigate the genetic association between DR and polymorphic variants of CDKAL1 in Chinese Han population with type 2 diabetes mellitus (T2DM). A well-defined population with T2DM, consisting of 475 controls and 105 DR patients, was recruited. All subjects were genotyped for the genetic variant (rs10946398) of CDKAL1. Genotyping was performed by iPLEX technology. The association between rs10946398 and T2DM was assessed by univariate and multivariate logistic regression (MLR) analysis.


RESULTS
There were significant differences in C allele frequencies of rs10946398 (CDKAL1) between control and DR groups (45.06% versus 55.00%, P<0.05). The rs10946398 of CDKAL1 was found to be associated with the increased risk of DR among patients with diabetes.


CONCLUSIONS
Our findings suggest that rs10946398 of CDKAL1 is independently associated with DR in a Chinese Han population.
Department of Endocrinology and Metabolism, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
Nai-Jia
NJ
Liu
Department of Endocrinology and Metabolism, Jing'an District Center Hospital of Shanghai, Shanghai 200040, China.
Qian
Q
Xiong
Department of Endocrinology and Metabolism, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
Hui-Hui
HH
Wu
Department of Endocrinology and Metabolism, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
Yan-Liang
YL
Li
Department of Endocrinology and Metabolism, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China.
Zhen
Z
Yang
Department of Endocrinology and Metabolism, Hua Dong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Xiao-Ming
XM
Tao
Department of Endocrinology and Metabolism, Hua Dong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Yan-Ping
YP
Du
Department of Endocrinology and Metabolism, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
Bin
B
Lu
Department of Endocrinology and Metabolism, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
Ren-Ming
RM
Hu
Department of Endocrinology and Metabolism, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
Xuan-Chun
XC
Wang
Department of Endocrinology and Metabolism, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
Jie
J
Wen
CDKAL1; Chinese Han population; association analysis; diabetic retinopathy; polymorphism