A Pd-Catalyzed Synthesis of Functionalized Piperidines.
A readily available cyclic carbamate 1 functions as a general precursor to a range of functionalized piperidine products via a new Pd-catalyzed annulation strategy. An asymmetric catalytic variant provides a rapid and efficient means to access these heterocycles with high to excellent levels of enantiocontrol. Finally, these richly functionalized compounds are amenable to further chemoselective elaboration.
Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, U.K.
Benjamin D W
BD
Allen
Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, U.K.
Matthew J
MJ
Connolly
Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, U.K.. j.harrity@sheffield.ac.uk.
Joseph P A
JP
Harrity
Pd catalysis; annulation; enantioselectivity; piperidine