Long non-coding RNAs in heart failure: an obvious lnc.
Heart failure is a life-threatening and costly ailment characterized by structural and functional impairment of the heart. Despite major advances in understanding protein-mediated transcriptional control and signaling pathways that underlie the cellular and interstitial alterations of heart failure, significant therapeutical breakthroughs for innovative treatments of this disease are still missing. The recent extensive profiling of the mammalian transcriptome has revealed a large number of long non-coding RNAs (lncRNAs) that play a diversity of important regulatory roles in gene expression. In here, we focus on a recent work by Ounzain and colleagues comprising genome-wide profiling of the cardiac transcriptome after myocardial infarction with an emphasis on the identification of novel heart-specific lncRNAs.
1 Department of Cardiology, Experimental Cardiology Laboratory, University Medical Center Utrecht, the Netherlands ; 2 UMC Utrecht Regenerative Medicine Center, University Medical Center Utrecht, the Netherlands ; 3 Netherlands Heart Institute (ICIN), Utrecht, the Netherlands.
Hamid
H
El Azzouzi
1 Department of Cardiology, Experimental Cardiology Laboratory, University Medical Center Utrecht, the Netherlands ; 2 UMC Utrecht Regenerative Medicine Center, University Medical Center Utrecht, the Netherlands ; 3 Netherlands Heart Institute (ICIN), Utrecht, the Netherlands.
Pieter Adrianus
PA
Doevendans
1 Department of Cardiology, Experimental Cardiology Laboratory, University Medical Center Utrecht, the Netherlands ; 2 UMC Utrecht Regenerative Medicine Center, University Medical Center Utrecht, the Netherlands ; 3 Netherlands Heart Institute (ICIN), Utrecht, the Netherlands.
Joost Petrus Gerardus
JP
Sluijter
Long non-coding RNA (lncRNA); gene networks; heart failure