Economic evaluation of 5-HT3 receptor antagonists in combination with dexamethasone for the prevention of 'overall' nausea and vomiting following highly emetogenic chemotherapy in Chinese adult patients.
Background Two pivotal Phase III trials compared the efficacy of palonosetron, ondansetron and granisetron, combined with dexamethasone, for the prevention of nausea and vomiting following highly emetogenic chemotherapy. However, an economic evaluation of these three regimens in the real-world setting of Chinese adult patients has not been determined. Objectives To estimate, from the perspective of the Chinese healthcare system, which of these frequently used strategies consisting of 0.25 mg palonosetron (0.25P), 16 mg ondansetron (Onda), and 3 mg granisetron (Gran), is the most cost-effective option in patients following highly emetogenic chemotherapy. Methods A Markov decision-analytic model was developed. The health and economic outcomes of the three strategies; 0.25P, Onda, and Gran were investigated. The clinical and utility data were taken from published studies. The cost data were calculated according to current local Chinese practices. Sensitivity analyses were performed to determine the impact of uncertainty regarding the results. Results The base-case analysis showed that the 0.25P strategy yielded maximum health benefits compared with the other two strategies. However, the probabilistic sensitivity analysis demonstrated that the Gran strategy was the most cost-effective approach when the willingness-to-pay threshold was not more than US$22,515/quality-adjusted life year. Moreover, palonosetron is not cost-effective in preventing 'overall' nausea and vomiting following highly emetogenic chemotherapy in Chinese patients. Conclusions Our analysis suggests that, compared with palonosetron and ondansetron, 3 mg granisetron may be a cost-effective treatment option in the current Chinese healthcare setting.
1 Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai, China.|2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Qiong
Q
Du
1 Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai, China.|2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Qing
Q
Zhai
1 Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai, China.|2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Bin
B
Zhu
1 Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai, China.|2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Xiao-Le
XL
Xu
1 Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai, China.|2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Bo
B
Yu
D000328:Adult; D000932:Antiemetics / Q000008:administration & dosage* / Q000191:economics / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects; D044466:Asian People; D017326:Clinical Trials, Phase III as Topic; D003362:Cost-Benefit Analysis; D003907:Dexamethasone / Q000008:administration & dosage*; D017829:Granisetron / Q000008:administration & dosage; D006801:Humans; D007546:Isoquinolines / Q000008:administration & dosage; D009325:Nausea / Q000139:chemically induced / Q000517:prevention & control*; D017294:Ondansetron / Q000009:adverse effects; D000077924:Palonosetron; D011812:Quinuclidines / Q000008:administration & dosage; D016032:Randomized Controlled Trials as Topic; D044406:Receptors, Serotonin, 5-HT3 / Q000187:drug effects; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
D000932:Antiemetics; D000970:Antineoplastic Agents; D003907:Dexamethasone; D017829:Granisetron; D007546:Isoquinolines; D017294:Ondansetron; D000077924:Palonosetron; D011812:Quinuclidines; D044406:Receptors, Serotonin, 5-HT3
5-HT3 receptor antagonists; Markov model; cost-effectiveness; highly emetogenic chemotherapy