Impaired interhemispheric synchrony in Parkinson's disease with depression.
The alterations of interhemispheric resting-state functional connectivity (FC) in Parkinson's disease (PD) with depression remain unclear, so we aimed to explore the differences of interhemispheric FC between PD with and without depression. Twenty-one depressed PD (DPD) patients, 49 non-depressed PD (NDPD) patients and 50 matched healthy controls (HC) participated in this study. Resting-state functional magnetic resonance imaging (fMRI) data were analyzed with the voxel-mirrored homotopic connectivity (VMHC) approach. The DPD patients showed lower VMHC values in the bilateral dorsolateral prefrontal cortex (DLPFC) and calcarine cortex compared to both NDPD and HC groups, and further receiver operating characteristic curves (ROC) analyses revealed that the VMHC in these two brain areas could be used as biomarkers to distinguish DPD from NDPD and from HC. The pooled PD patients (both DPD and NDPD) exhibited decreased VMHC in the bilateral putamen, middle occipital gyrus (MOG), postcentral gyrus (PoCG), paracentral lobule (PCL) and cerebellum posterior lobe when compared with HC. Decreased VMHC values within the DLPFC and calcarine cortex appeared to be unique features for DPD and might be used as potential neuroimaging markers to distinguish DPD patients from NDPD and HC groups. These findings may underlie the neural mechanisms of depression in PD.
Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China.
Yajing
Y
Zhu
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
Xiaopeng
X
Song
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.
Mingze
M
Xu
Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China.
Xiao
X
Hu
Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China.
Erfeng
E
Li
Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China.
Jiajia
J
Liu
Department of Psychiatry and Psychosomatics, Affiliated ZhongDa Hospital of Southeast University, The Institute of Neuropsychiatry of Southeast University, Nanjing 210009, China.
Yonggui
Y
Yuan
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.|Center for MRI Research, Beijing City Key Lab for Medical Physics and Engineering, McGovern Institution for Brain Research, Peking University, Beijing 100871, China.
Jia-Hong
JH
Gao
Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China.
Weiguo
W
Liu
D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D003863:Depression / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*