Bioavailability and bioconcentration potential of perfluoroalkyl-phosphinic and -phosphonic acids in zebrafish (Danio rerio): Comparison to perfluorocarboxylates and perfluorosulfonates.
Currently, information regarding bioavailability and bioconcentration potential of perfluoroalkyl phosphinic acids (PFPiAs) in aquatic organisms does not exist. The main objective of the present study was to assess uptake and elimination kinetics of PFPiAs in zebrafish (Danio rerio) following aqueous exposure. The results showed that PFPiA exposure can result in very high steady-state bioconentration factors (BCFss), compared to perfluorocarboxylates and perfluorosulfonates.C6/C10 PFPiA exhibited the highest BCFss, ranging between 10(7) and 10(10), orders of magnitude higher than those for long-chain perfluorocarboxylates. Strong positive relationships were observed between BCFss versus the membrane-water distribution coefficient (Dmw) and the protein-water partition coefficient (Kpw) of the studied perfluoroalkyl substances. However, BCFss exhibited a substantial drop for the very hydrophobic PFPiAs (C8/C10 and C6/C12 PFPiAs). The reduced BCFss of these long-chain PFPiAs (perfluoroalkyl chain length=18; Dmw=10(9)) is likely the result of reduced bioavailability due to interaction with solute molecules/organic matter present in the water phase and/or reduced gill membrane permeability. While PFPiAs can be metabolized to perfluoroalkyl phosphonic acids, the metabolic transformation rate seems insufficient to counteract the high degree of uptake across gill membranes. These findings help to better understand exposure pathways and bioaccumulation behavior of these important perfluorinated acids in aquatic systems.
Graduate School of Integrated Sciences and Engineering (NGS), National University of Singapore, Singapore.
Fangfang
F
Chen
Graduate School of Integrated Sciences and Engineering (NGS), National University of Singapore, Singapore; Department of Biological Sciences, National University of Singapore, Singapore.
Zhiyuan
Z
Gong
Department of Civil and Environmental Engineering, National University of Singapore, Singapore. Electronic address: bckelly@nus.edu.sg.
Barry C
BC
Kelly
D000818:Animals; D001682:Biological Availability; D005260:Female; D005466:Fluorocarbons / Q000378:metabolism*; D007700:Kinetics; D010721:Phosphinic Acids / Q000378:metabolism*; D010757:Phosphorous Acids / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000378:metabolism*; D015027:Zebrafish / Q000378:metabolism*
D005466:Fluorocarbons; D010721:Phosphinic Acids; D010757:Phosphorous Acids; D014874:Water Pollutants, Chemical
Bioaccumulation; Bioconcentration factors; Kinetics; Perfluoroalkyl phosphinic acids; Perfluoroalkyl phosphonic acids; Zebrafish