Synchronized and controlled release of metformin hydrochloride/glipizide from elementary osmotic delivery.
The combination of metformin hydrochloride (MTF) and glipizide (GLZ) is second-line medication for diabetes mellitus type 2 (DMT2). In the present study, elementary osmotic pump ( EOP) tablet is designed to deliver the combination of MTF and GLZ in a sustained and synchronized manner. By analyzing different variables of the formulation, sodium hydrogen carbonate is introduced as pH modifier to improve the release of GLZ, while ethyl cellulose acts as release retardant to reduce the burst release phase of MTF. A two-factor, three-level face-centered central composite design (FCCD) is applied to investigate the impact of different factors on drug release profile. Compared with conventional tablets, the EOP tablet demonstrates a controlled release behavior with relative bioavailability of 99.2% for MTF and 99.3% for GLZ. Data also shows EOP tablet is able to release MTF and GLZ in a synchronized and sustained manner both in vitro and in vivo.
a Natural Drug Discovery Group , School of Pharmacy, Queen's University Belfast , Belfast , UK.
Hao
H
Pan
b Nanjing Chia Tai Tianqing Pharmaceutical Co. Ltd., Nanjing Economic and Technological Development Zone , Nanjing , Jiangsu , China.
Hengpan
H
Jing
c Department of Pharmaceutics , Shenyang Pharmaceutical University , Shenyang , P.R. China.
Xinggang
X
Yang
c Department of Pharmaceutics , Shenyang Pharmaceutical University , Shenyang , P.R. China.
Weisan
W
Pan
a Natural Drug Discovery Group , School of Pharmacy, Queen's University Belfast , Belfast , UK.
Tianbao
T
Chen
D001682:Biological Availability; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D005913:Glipizide / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000737:chemistry; D008687:Metformin / Q000737:chemistry*; D009995:Osmosis / Q000187:drug effects*; D012995:Solubility; D013607:Tablets / Q000737:chemistry
D003692:Delayed-Action Preparations; D007004:Hypoglycemic Agents; D013607:Tablets; C013517:ethyl cellulose; D002482:Cellulose; D008687:Metformin; D005913:Glipizide
Elementary osmotic pump (EOP); face-centered central composite design; metformin hydrochloride/glipizide; synchronized and sustained release