Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg.
Campomanesia xanthocarpa (Myrtaceae) is used in Brazilian traditional medicine against fever, diabetes, hypercholesteremic, obesity, and urinary diseases. In the present study, the compounds 2',6'-dihydroxy-3'-methyl-4'-metoxychalcone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone were identified for the first time in leaves of the C. xanthocarpa. These compounds and the hydroethanolic extract (HECX) significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. No toxicity was detected by HECX in an acute toxicity test.
Program in Natural Resources, State University of Mato Grosso do Sul, Dourados, MS, Brazil. elicarenata@hotmail.com.|Universidade Estadual de Mato Grosso do Sul, CEP 79804-970, C.P. 351, Dourados, MS, Brazil. elicarenata@hotmail.com.
Élica Renata Soares
ÉR
da Silva
Universidade Estadual de Mato Grosso do Sul, CEP 79804-970, C.P. 351, Dourados, MS, Brazil.
Gustavo Ruivo
GR
Salmazzo
College of Health Science, Federal University of Grande Dourados, Dourados, MS, Brazil.
Jucicléia
J
da Silva Arrigo
School of Medicine "Dr. Hélio Mandetta" (FAMED), Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.
Rodrigo Juliano
RJ
Oliveira
College of Health Science, Federal University of Grande Dourados, Dourados, MS, Brazil.
Candida Aparecida Leite
CA
Kassuya
Program in Natural Resources, State University of Mato Grosso do Sul, Dourados, MS, Brazil. claudia@uems.br.|Universidade Estadual de Mato Grosso do Sul, CEP 79804-970, C.P. 351, Dourados, MS, Brazil. claudia@uems.br.
Cláudia Andréa Lima
CA
Cardoso
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D001938:Brazil; D002465:Cell Movement / Q000187:drug effects; D047188:Chalcones / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004487:Edema / Q000188:drug therapy; D007962:Leukocytes / Q000166:cytology; D008519:Medicine, Traditional / Q000379:methods; D051379:Mice; D027822:Myrtaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D035422:Pleural Cavity / Q000378:metabolism; D011506:Proteins / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D047188:Chalcones; D010936:Plant Extracts; D011506:Proteins
Campomanesia xanthocarpa; Myrtaceae; guavira; inflammation