DatSCAN In Differential Diagnostics of Lewy Body Disease.
Differential diagnosis between Lewy body disease and Alzheimer´s disease might be difficult because of similarities of clinical symptoms in both neurodegenerative diseases. DatSCAN is a modern functional neuroimmaging method which differentiates between this similar diseases and helps in correct treatment strategy. We report our positive experience with DatSCAN in differentiating Lewy body disease from Alzheimer´s disease. This is a case report of a woman with Lewy body disease, initially diagnosed as Alzheimer´s disease. DatSCAN neuroimmaging method was used in differential diagnosis of dementia. Memory impairment, impaired activities of daily living, sleep and behavioral disturbances were present in our case. Donepezil was well tolerated, but haloperidol administration was followed by development of severe dystonia. DatSCAN showed deficient dopaminergic presynaptic transport in substantia nigra and striatum. This finding is typical for Lewy body disease not for Alzheimer´s disease. DatSCAN neuroimmaging is a suitable method for differentiating Lewy body disease from Alzheimer´s disease. Deficient dopaminergic presynaptic transport in substantia nigra and striatum is typical for Lewy body disease.
Mental Hospital in Kromeriz, Czech Republic.
Jan
J
Luzny
Department of Social Medicine and Public Health, Faculty of Medicine, Palacky University Olomouc, Czech Republic.
Katerina
K
Ivanova
D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging; D018153:Czech Republic; D003937:Diagnosis, Differential; D000077265:Donepezil; D005260:Female; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D020961:Lewy Body Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D010880:Piperidines / Q000627:therapeutic use*; D009435:Synaptic Transmission / Q000187:drug effects*; D014057:Tomography, X-Ray Computed
D007189:Indans; D010880:Piperidines; D000077265:Donepezil