Prothrombin fragment 1+2 as a sensitive marker of intraventricular thrombus formation in a patient with dilated cardiomyopathy: comparison with echocardiography.
A 50-year-old man with dilated cardiomyopathy was admitted to our hospital due to heart failure symptoms. Although prothrombin fragment 1+2 (F1+2) was significantly elevated, there was no thrombus in the left ventricle by echocardiography. However, anticoagulation therapy was started because of a possibility of thrombus formation. On the 4th day, F1+2 was persistently elevated and echocardiography detected intraventricular thrombi. After surgical removal of thrombi, F1+2 level decreased rapidly. F1+2 elevation preceded echocardiographic detection of intraventricular thrombi. Therefore, when F1+2 is significantly elevated, echocardiography should be performed meticulously and repeatedly to detect a thrombus.
Division of Functional Diagnostics, Department of Health Sciences, Osaka University Graduate School of Medicine, 1-7 Yamadaoka, Suita, Osaka, 565-0871, Japan. takakomt@belle.shiga-med.ac.jp.|Department of Clinical Laboratory Medicine, Hospital of Shiga University of Medical Science, Seta Tsukinowa-cho, Ostu, Shiga, 520-2192, Japan. takakomt@belle.shiga-med.ac.jp.
Takako
T
Ishigaki
Department of Clinical Laboratory Medicine, Hospital of Shiga University of Medical Science, Seta Tsukinowa-cho, Ostu, Shiga, 520-2192, Japan.
Takashi
T
Yoshida
Department of Clinical Laboratory Medicine, Hospital of Shiga University of Medical Science, Seta Tsukinowa-cho, Ostu, Shiga, 520-2192, Japan.
Hiroko
H
Okuno
Department of Clinical Laboratory Medicine, Hospital of Shiga University of Medical Science, Seta Tsukinowa-cho, Ostu, Shiga, 520-2192, Japan.
Yoshihisa
Y
Fujisawa
Department of Clinical Laboratory Medicine, Hospital of Shiga University of Medical Science, Seta Tsukinowa-cho, Ostu, Shiga, 520-2192, Japan.
Shoko
S
Shimizu
Department of Clinical Laboratory Medicine, Hospital of Shiga University of Medical Science, Seta Tsukinowa-cho, Ostu, Shiga, 520-2192, Japan.
Shizuo
S
Isogawa
Department of Clinical Laboratory Medicine, Hospital of Shiga University of Medical Science, Seta Tsukinowa-cho, Ostu, Shiga, 520-2192, Japan.
Hidetoshi
H
Okabe
Division of Functional Diagnostics, Department of Health Sciences, Osaka University Graduate School of Medicine, 1-7 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Satoshi
S
Nakatani
Idiopathic dilated cardiomyopathy; Prothrombin fragment 1+2; Thrombosis; Transthoracic echocardiography