Inflammation: a trigger for acute coronary syndrome.
Atherosclerosis is a chronic inflammatory disease of the vessel wall and a major cause of death worldwide. One of atherosclerosis' most dreadful complications are acute coronary syndromes that comprise ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, and unstable angina. We now understand that inflammation substantially contributes to the initiation, progression, and destabilization of atherosclerosis. In this review, we will focus on the role of inflammatory leukocytes, which are the cellular protagonists of vascular inflammation, in triggering disease progression and, ultimately, the destabilization that causes acute coronary syndromes.
German Heart Center Munich, Department of Cardiovascular Diseases, Munich, Germany - hendrik.sager@tum.de.
Hendrik B
HB
Sager
Matthias
M
Nahrendorf
D054058:Acute Coronary Syndrome / Q000503:physiopathology*; D000818:Animals; D050197:Atherosclerosis / Q000097:blood / Q000503:physiopathology; D001854:Bone Marrow Cells / Q000166:cytology; D018450:Disease Progression; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood; D006943:Hyperglycemia / Q000097:blood; D007249:Inflammation / Q000503:physiopathology*; D051379:Mice; D009000:Monocytes / Q000166:cytology; D009504:Neutrophils / Q000378:metabolism; D010641:Phenotype; D058226:Plaque, Atherosclerotic / Q000378:metabolism