Salivary latent trait cortisol (LTC): Relation to lipids, blood pressure, and body composition in middle childhood.
Adversity experienced early in life has the potential to influence physical health later in life. The stress-health relation may be partially explained by stress-related effects on cardiovascular risk factors. This study explored links between individual differences in trait-like variation in the activity of the hypothalamic-pituitary-adrenal (HPA) axis with cardiovascular risk factors in children. 474 children (M age=9.22years; 54% female; 83% Caucasian) were included in this study, in which cardiovascular risk was assessed using the following indices - triglycerides (TG), HDL-cholesterol (HDL-C), glucose (Glu); resting systolic and diastolic blood pressure, body mass index (BMI), waist-to-hip ratio, and % fat. Saliva samples were measured 3 times a day (waking, 30min post-waking and bedtime) over 3days (later assayed for cortisol). A latent trait cortisol (LTC) factor explained 43% of the variance in cortisol levels within and across days. Confirmatory factor analysis identified three cardiovascular risk factors: lipids (i.e., TG and HDL-C), blood pressure (i.e., systolic and diastolic), and body composition (i.e., BMI, Waist-to-hip ratio, and % fat). Lower salivary LTC was associated with higher lipids, higher blood pressure, and higher body composition. The findings further support the internal and external validity of the LTC construct, and may also advance our understanding of the link between interindividual differences in HPA axis activity and cardiovascular risk in middle childhood.
Department of Psychology, Arizona State University, Tempe, AZ 85287-3604, USA; Institute for Interdisciplinary Salivary Bioscience Research, University of California at Irvine, Irvine, CA 92697-7085, USA. Electronic address: Wan.Yeung@asu.edu.
Ellen W
EW
Yeung
Department of Exercise and Sport Performance, University of New England, Biddeford, ME 04005, USA.
Rebecca
R
Place
George Washington University School of Medicine, Children's National Medical Center, Washington, DC 20010, USA.
Heather
H
Gordish-Dressman
Department of Exercise and Sport Performance, University of New England, Biddeford, ME 04005, USA.
Paul
P
Visich
Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20012, USA.
Eric
E
Hoffman
The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA; The Johns Hopkins University School of Education, Baltimore, MD 21218, USA; Institute for Interdisciplinary Salivary Bioscience Research, University of California at Irvine, Irvine, CA 92697-7085, USA.
Sheila O
SO
Walker
Department of Psychology, Arizona State University, Tempe, AZ 85287-3604, USA; The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA; The Johns Hopkins University School of Nursing, Baltimore, MD 21205, USA; The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA; Institute for Interdisciplinary Salivary Bioscience Research, University of California at Irvine, Irvine, CA 92697-7085, USA.
Douglas A
DA
Granger
D001794:Blood Pressure / Q000502:physiology; D001823:Body Composition / Q000502:physiology*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology; D002648:Child; D008076:Cholesterol, HDL / Q000032:analysis / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis* / Q000737:chemistry / Q000502:physiology*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000032:analysis; D008281:Maine; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology; D012307:Risk Factors; D012463:Saliva; D049629:Waist-Hip Ratio
D008076:Cholesterol, HDL; D007328:Insulin; D008055:Lipids; D006854:Hydrocortisone
Blood pressure; Body composition; Latent trait cortisol (LTC); Lipids; Middle childhood; Toxic stress