Tapping out a mechanical code for T cell triggering.
Mechanical forces play increasingly recognized roles in T cell receptor (TCR) signal transduction. Hu and Butte (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511053) demonstrate that actin is required for T cells to generate forces at the TCR and that exogenous application of force can emulate these cytoskeletal forces and trigger T cell activation.
Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskelatal Sciences, The University of Oxford, Oxford OX3 7FY, England, UK Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016 michael.dustin@kennedy.ox.ac.uk.
Michael L
ML
Dustin
Department of Biomedical Engineering, Columbia University, New York, NY 10027.
Lance C
LC
Kam
D000818:Animals; D006801:Humans; D008213:Lymphocyte Activation; D018625:Microscopy, Atomic Force; D008954:Models, Biological; D011948:Receptors, Antigen, T-Cell; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000378:metabolism*
D011948:Receptors, Antigen, T-Cell