The roots of Salvia rhytidea: a rich source of biologically active diterpenoids.
Sahandinone (1), 12-deoxysalvipisone (2), miltirone (3), 7α-acetoxyroyleanone (4), and labda-7,14-dien-13-ol (5) were isolated from the roots of Salvia rhytidea Benth. (Lamiaceae). Their structures were elucidated by a combination of spectroscopic analyses including EIMS and NMR. The13C NMR spectroscopic data were revised for the quaternary carbons of both 1 and 3 with the help of HMBC spectra in respect to the spectral data previously reported in the literature. Compounds 1 and 3, two very potent anticancer agents, were isolated in high yields from the roots of the plant. The biological activities of the plants' constituents were reported in the literature as antimicrobial, cytotoxic and antimalarial are discussed in this article.
a Medicinal and Natural Products Chemistry Research Center , Shiraz University of Medical Sciences , Shiraz , Iran.
Amir Reza
AR
Jassbi
b Department of Chemistry , University of Sistan and Baluchestan , Zahedan , Iran.
Farrokh
F
Eghtesadi
b Department of Chemistry , University of Sistan and Baluchestan , Zahedan , Iran.
Nourallah
N
Hazeri
b Department of Chemistry , University of Sistan and Baluchestan , Zahedan , Iran.
Hashem
H
Ma'sumi
c Faculty of Science, Department of Biology , University of Sistan and Baluchestan , Zahedan , Iran.
Jafar
J
Valizadeh
d Research Group Biosynthesis/NMR , Max Planck Institute for Chemical Ecology , Jena , Germany.
Jima N
JN
Chandran
d Research Group Biosynthesis/NMR , Max Planck Institute for Chemical Ecology , Jena , Germany.
Bernd
B
Schneider
e Department of Molecular Ecology , Max Planck Institute for Chemical Ecology , Jena , Germany.
Ian T
IT
Baldwin
D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000032:analysis; D018517:Plant Roots / Q000737:chemistry; D027544:Salvia / Q000737:chemistry*
D004224:Diterpenes; D010936:Plant Extracts
Salvia rhytidea; abietane diterpenoids; labdane diterpenoid