Right- and left-sided carcinoid heart disease without intracardiac shunting.
We present a case of a 54-year-old man with carcinoid heart disease and mitral valve involvement. He had hepatic carcinoid with an extremely elevated urinary excretion of 5-hydroxyindole acetic acid and was referred to our division for shortness of breath and leg edema. Transthoracic echocardiography showed the thickened and retracted tricuspid valve leaflets and severe tricuspid regurgitation. Moderate mitral regurgitation was observed, with the involvement of mitral valve leaflets. A patent foramen ovale was not detected on transesophageal echocardiography. The extremely high concentration of circulating serotonin and/or other vasoactive substances may have contributed to left- as well as right-sided carcinoid heart disease.
Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan. sinkateyou@yahoo.co.jp.
Go
G
Igawa
Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan.
Katsunori
K
Ishida
Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan.
Koichi
K
Matsubara
Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan.
Yoshiharu
Y
Kinugasa
Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan.
Kazuyoshi
K
Ogura
Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan.
Masahiko
M
Kato
Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan.
Kazuhiro
K
Yamamoto
Carcinoid heart disease; Echocardiography; Mitral valve; Serotonin; Tricuspid valve