Single-Pot Asymmetric Approach toward Enantioenriched Quaternary Stereocenter-Containing Alkylidenecyclobutanes.
Enantioenriched alkylidenecyclobutanes possessing a quaternary stereogenic center, usually difficult to access, have been synthesized by combining a double boron-homologation and an allylboration through a highly efficient and diastereoselective one-pot process. Starting from commercially available substrates, this protocol represents a simple way of accessing chiral unsaturated four-membered ring systems with excellent stereoisomeric ratios.
Department of Chemistry and Pharmacy, Ludwig-Maximilians-University , Butenandtstrasse 5-13, 81377 Munich, Germany.
Michael
M
Eisold
Department of Chemistry and Pharmacy, Ludwig-Maximilians-University , Butenandtstrasse 5-13, 81377 Munich, Germany.
Gabriel M
GM
Kiefl
Department of Chemistry and Pharmacy, Ludwig-Maximilians-University , Butenandtstrasse 5-13, 81377 Munich, Germany.
Dorian
D
Didier