Enantioselective Intramolecular C-H Insertion of Donor and Donor/Donor Carbenes by a Nondiazo Approach.
The first enantioselective intramolecular C-H insertion and cyclopropanation reactions of donor- and donor/donor-carbenes by a nondiazo approach are reported. The reactions were conducted in a one-pot manner without slow addition and provided the desired dihydroindole, dihydrobenzofuran, tetrahydrofuran, and tetrahydropyrrole derivatives with up to 99 % ee and 100 % atom efficiency.
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
Dong
D
Zhu
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
Jun
J
Ma
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China.
Kui
K
Luo
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, P.R. China.
Hongguang
H
Fu
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, P.R. China. zhli99@mail.sysu.edu.cn.
Li
L
Zhang
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China. zhusf@scut.edu.cn.|State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China. zhusf@scut.edu.cn.
Shifa
S
Zhu
asymmetric catalysis; carbenes; heterocycles; insertion; rhodium