Lesional cerebellar epilepsy: a review of the evidence.
Classical teaching in epileptology localizes the origins of focal seizures solely in the cerebral cortex, with only inhibitory effects attributed to subcortical structures. However, electrophysiological and neuroimaging studies over the last decades now provide evidence for an initiation of epileptic seizures within subcortical structures. Intrinsic epileptogenicity of hypothalamic hamartoma has already been established in recognition of subcortical epilepsy, whereas a seizure-generating impact of dysplastic cerebellar lesions remains to be clarified. Herein, we examine the supportive evidence and clinical presentation of cerebellar seizures and review therapy options.
Department of Neurosurgery, University Hospital Freiburg, Breisacher Str. 60, 79106, Freiburg, Germany. niels.foit@uniklinik-freiburg.de.|Freiburg Brain Imaging, Breisacher Str. 60, 79106, Freiburg, Germany. niels.foit@uniklinik-freiburg.de.
Niels A
NA
Foit
Department of Neurosurgery, University Hospital Freiburg, Breisacher Str. 60, 79106, Freiburg, Germany.
Vera
V
van Velthoven
Bethel Epilepsy Center, Krankenhaus Mara, Maraweg 21, 33617, Bethel, Germany.
Reinhard
R
Schulz
University Hospital Erlangen, Institut für Neuropathologie, Schwabachanlage 6, 91054, Erlangen, Germany.
Ingmar
I
Blümcke
Freiburg Brain Imaging, Breisacher Str. 60, 79106, Freiburg, Germany.|Department of Neuroradiology, University of Freiburg, Breisacher Str. 60, 79105, Freiburg, Germany.
Horst
H
Urbach
Bethel Epilepsy Center, Krankenhaus Mara, Maraweg 21, 33617, Bethel, Germany.
Friedrich G
FG
Woermann
Bethel Epilepsy Center, Krankenhaus Mara, Maraweg 21, 33617, Bethel, Germany.
Christian G
CG
Bien
D000818:Animals; D002526:Cerebellar Diseases / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy; D006801:Humans
Cerebellum; Epilepsy; Hamartoma; Seizures; Surgery