Association between omentin and echo parameters in patients with chronic heart failure.
Adipose-derived adipokines have been demonstrated to be associated with the development of experimental heart disease through chronic inflammation and cardiac cell apoptosis. Omentin is to be one of the novel adipokines. The aim of this study is to investigate the relationship between circulating omentin and cardiac dysfunction in patients with chronic heart failure (CHF).



A total of 189 CHF patients were studied, determining serum omentin and echocardiographic parameters. All participants were divided into two experimental groups: the 111 patients who had a left ventricular ejection fraction (EF) ≥40% (EF-H) and the 78 patients exhibiting EF values <40% (EF-L).



The EF-L group showed significantly higher circulating omentin levels compared to the EF-H group (210.8±67.2 vs. 155.3±45.3, P<0.001; Student's t-test). Overall, the data of the linear regression analysis revealed that serum omentin levels correlated positively with left atrial diameters (r=0.31, P=0.006), left ventricular end-systolic dimensions (r=0.42, P<0.001), and left ventricular end-diastolic dimensions (r=0.38, P=0.002) and negatively with left ventricular EF (r=-0.45, P=0.001; Spearmen's rank correlations coefficients for each). The multiple regression model included all variables at p<0.1 by the univariate analysis. A multiple logistic regression analysis demonstrated that high levels of patients' serum omentin were associated with cardiac dysfunction in patients with CHF (OR=1.22; 95% CI: 0.91-1.58; P=0.009).



These findings suggested that elevated serum omentin levels were only very mildly related to the changes in cardiac volume and function in CHF patients. Further studies are then needed to assess the real clinical value of omentin in this setting.
Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanbian University, Yanji, China - chengxw0908@163.com.
Haiying
H
Jiang
Guangxian
G
Zhao
Xiang
X
Li
Hongyan
H
Jin
Guang
G
Yang
Kuiyue
K
Jin
Limei
L
Piao
Enbo
E
Zhu
Yanna
Y
Lei
Ennan
E
Fang
Xiongyi
X
Han
Yongshan
Y
Nan
Qinghua
Q
Jin
Xianwu
X
Cheng
D000368:Aged; D015415:Biomarkers; D002908:Chronic Disease; D016207:Cytokines / Q000097:blood*; D004452:Echocardiography; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology
D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins