Down-regulation of miR-133a as a poor prognosticator in non-small cell lung cancer.
miR-133a has been demonstrated to play an important role in tumor progression. The aim of present study was to analyze the correlation between miR-133a expression level and clinicopathologic features and its prognostic significance in non-small cell lung cancer (NSCLC). The expression of miR-133a in 104 pairs of human lung cancer tissues and adjacent normal lung tissues were analyzed by qRT-PCR. Here we show that miR-133a was down-regulated in NSCLC. The levels of miR-133a were negatively correlated with the status of N classification (N0-N1 vs. N2-N3, P=0.000), clinical stage (I-II vs. III-IV, P=0.010) and MMP-14 expression (High vs. Low, P=0.012). The patients with low miR-133a expression had shorter survival time than those with high miR-133a expression. Multivariate analysis indicated that the level of miR-133a expression was an independent prognostic indicator (P=0.012) for the survival of patients with NSCLC. In conclusion, decreased expression of miR-133a might be a potential unfavorable prognostic factor for patients with NSCLC, and further studies would be needed to prove our findings.
Oncology Center, Affiliated Hospital of Guangdong Medical University, No. 57 Peoples Avenue South, Zhanjiang, Guangdong 524001, People's Republic of China.
Yuzhou
Y
Wang
Department of Radiation Oncology, Central Hospital of Guangdong Nongken, No. 2 Peoples Avenue, Zhanjiang, Guangdong 524022, People's Republic of China.
Jinmei
J
Li
Department of Urology, Central Hospital of Guangdong Nongken, No. 2 Peoples Avenue, Zhanjiang, Guangdong 524022, People's Republic of China.
Hongming
H
Chen
Oncology Center, Affiliated Hospital of Guangdong Medical University, No. 57 Peoples Avenue South, Zhanjiang, Guangdong 524001, People's Republic of China.
Yanli
Y
Mo
Oncology Center, Affiliated Hospital of Guangdong Medical University, No. 57 Peoples Avenue South, Zhanjiang, Guangdong 524001, People's Republic of China.
Haiyin
H
Ye
Oncology Center, Affiliated Hospital of Guangdong Medical University, No. 57 Peoples Avenue South, Zhanjiang, Guangdong 524001, People's Republic of China.
Yiping
Y
Luo
Oncology Center, Affiliated Hospital of Guangdong Medical University, No. 57 Peoples Avenue South, Zhanjiang, Guangdong 524001, People's Republic of China.
Kangwen
K
Guo
Oncology Center, Affiliated Hospital of Guangdong Medical University, No. 57 Peoples Avenue South, Zhanjiang, Guangdong 524001, People's Republic of China.
Zongjiong
Z
Mai
Oncology Center, Affiliated Hospital of Guangdong Medical University, No. 57 Peoples Avenue South, Zhanjiang, Guangdong 524001, People's Republic of China.
Ying
Y
Zhang
Oncology Center, Affiliated Hospital of Guangdong Medical University, No. 57 Peoples Avenue South, Zhanjiang, Guangdong 524001, People's Republic of China.
Baoying
B
Chen
Oncology Center, Affiliated Hospital of Guangdong Medical University, No. 57 Peoples Avenue South, Zhanjiang, Guangdong 524001, People's Republic of China.
Yijin
Y
Zhou
Oncology Center, Affiliated Hospital of Guangdong Medical University, No. 57 Peoples Avenue South, Zhanjiang, Guangdong 524001, People's Republic of China. Electronic address: yangzhixiong068@126.com.
Zhixiong
Z
Yang
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality / Q000503:physiopathology; D015536:Down-Regulation; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality / Q000503:physiopathology; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D008875:Middle Aged; D011379:Prognosis; D012334:RNA, Neoplasm / Q000096:biosynthesis / Q000235:genetics; D016019:Survival Analysis
D014408:Biomarkers, Tumor; C548234:MIRN133 microRNA, human; D035683:MicroRNAs; D012334:RNA, Neoplasm
Biomaker; MiR-133a; NSCLC; Prognosis