Nonrespiratory mortality and cancer incidence in a cohort of Canadian nickel workers.
Mortality and cancer incidence were examined for an updated cohort of nonsinter nickel workers in Sudbury and Port Colborne, Ontario, Canada. Abstract results are provided for those with ≥ 15 years since first exposure. For circulatory disease mortality, significant elevations were observed overall in many Sudbury work areas and in Port Colborne staff. Underground miners, with first exposure before 1960, displayed significant elevations for pneumoconiosis, as well as silicosis and anthrasilicosis, likely due to crystalline silica. Significant elevations in colorectal cancer incidence were observed in Sudbury underground mining, mining maintenance, and maintenance work areas. Given a case-control study is not practical, the next cohort update should include more detailed occupational exposure assessment, including dust exposure, diesel engine emissions, solvents, various metals, silica, and sulphur dioxide.
a School of Rural and Northern Health , Laurentian University , Sudbury , Ontario , Canada.
Nancy E
NE
Lightfoot
b Occupational Cancer Research Centre , Cancer Care Ontario , Toronto , Ontario , Canada.
Colin J
CJ
Berriault
c SKS Consulting Services , Siler City , North Carolina , USA.
Steven K
SK
Seilkop
d BR Conard Consulting Inc. , Oakville , Ontario , Canada.
Bruce R
BR
Conard
D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000401:mortality; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000401:mortality; D006801:Humans; D015994:Incidence; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced / Q000453:epidemiology / Q000401:mortality; D008297:Male; D008669:Metallurgy; D008875:Middle Aged; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology* / Q000401:mortality; D009532:Nickel / Q000633:toxicity*; D016273:Occupational Exposure; D009864:Ontario / Q000453:epidemiology; D011471:Prostatic Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000401:mortality; D012189:Retrospective Studies; D055815:Young Adult
D009532:Nickel
Cancer incidence; cohort; mortality; nickel; occupational epidemiology