Enigmatic Inv(9): A Case Report on Rare Findings in Hematological Malignancies.
BACKGROUND
Inversion of chromosome 9 had been widely discussed among geneticists and evolutionary biologists because of its significant impact on various hereditary disorders and in the evolution of man. The role of such inversions in human disease evolution is an area hitherto unclear.


METHODS
We present the case of a chronic myeloid leukemia (CML) patient who showed intermittent relapse on treatment, with a rare appearance of clones with dual inversion (9) breakpoints [inv(9)(p22q34); inv(9)(p11q21)]. We also present the first report of inv(9)(p11,q13) as the sole abnormality in a patient with chronic myeloproliferative disorder(CMPD). Both the patients registered in 2012 and were from Kerala, India.


CONCLUSIONS
Both the cases discussed in our study have inv(9) as the sole abnormality and are found to confer a relatively poor prognosis.
Regional Cancer Centre, Division of Cancer Research, Medical College PO, Thiruvananthapuram-695 011, Kerala, India.
Sangeetha
S
Vijay
Regional Cancer Centre, Division of Medical Oncology, Medical College PO, Thiruvananthapuram-695 011, Kerala, India.
Geetha
G
Narayanan
Regional Cancer Centre, Division of Cancer Research, Medical College PO, Thiruvananthapuram-695 011, Kerala, India.
Santhi
S
Sarojam
Regional Cancer Centre, Division of Cancer Research, Medical College PO, Thiruvananthapuram-695 011, Kerala, India.
Suresh Kumar
SK
Raveendran
Regional Cancer Centre, Division of Cancer Research, Medical College PO, Thiruvananthapuram-695 011, Kerala, India.
Sreedharan
S
Hariharan
BCR-ABL Positive; Chromosome 9; Chronic Myelogenous Leukemia; Chronic Myeloproliferative Disorder; Inversion