Four New Monoterpenoid Glycosides from the Flower Buds of Magnolia biondii.
Four new monoterpenoid glycosides 1-4, named magnoliaterpenoid A-D, were isolated from a 50% aqueous acetone extract of flower buds of Magnolia biondii, along with one known compound, (1'R,3'S,5'R,8'S,2Z,4E)-dihydrophaseic acid 3-O-β-d-glucopyranoside (5). Their structures and relative configuration were identified by extensive spectroscopic analysis (IR, UV, MS, 1D and 2D NMR). The aglycones of these four new compounds possess seven-membered rings systems, which are very rare. A plausible biosynthetic route for the four new compounds was proposed via the biogenetic isoprene rule. Compounds 1, 2, 3, and 4 showed no antimicrobial activity at the concentration range of 1.95-250 µg/mL.
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment &amp; Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China. fwsh@hactcm.edu.cn.|School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China. fwsh@hactcm.edu.cn.
Wei-Sheng
WS
Feng
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment &amp; Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China. 13071020601@163.com.|School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China. 13071020601@163.com.
Yu-Huan
YH
He
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment &amp; Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China. zhengxk.2006@163.com.|School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China. zhengxk.2006@163.com.
Xiao-Ke
XK
Zheng
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment &amp; Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China. 15238397097@163.com.|School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China. 15238397097@163.com.
Jian-Chao
JC
Wang
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment &amp; Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China. caoyangang1987@126.com.|School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China. caoyangang1987@126.com.
Yan-Gang
YG
Cao
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment &amp; Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China. zyl2013hnzy@163.com.|School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China. zyl2013hnzy@163.com.
Yan-Li
YL
Zhang
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment &amp; Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China. songky5901@163.com.|School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China. songky5901@163.com.
Kai
K
Song
D000890:Anti-Infective Agents / Q000737:chemistry; D035264:Flowers / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D031566:Magnolia / Q000737:chemistry*; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification*; D010936:Plant Extracts / Q000737:chemistry
D000890:Anti-Infective Agents; D006027:Glycosides; D039821:Monoterpenes; D010936:Plant Extracts
Magnoliaceae; biosynthetic route; flower buds of Magnolia biondii; monoterpenoid glycosides