Chemical and biological studies of reveromycin A.
The research on antibiotics requires the integration of broad areas, such as microbiology, organic chemistry, biochemistry and pharmacology. It is similar to the field of chemical biology that is recently popular as an approach for drug discovery. When we isolate a new compound from a microorganism, we can pursue the interesting research on chemistry and biology. In this review, I would like to introduce our achievements in relation to reveromycin A.
RIKEN Center for Sustainable Research Science, Saitama, Japan.
Hiroyuki
H
Osada
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D055808:Drug Discovery; D006801:Humans; D051379:Mice; D010010:Osteoclasts / Q000187:drug effects; D011714:Pyrans / Q000737:chemistry* / Q000494:pharmacology*; D013141:Spiro Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D011714:Pyrans; D013141:Spiro Compounds; C068098:reveromycin A