Clinical Impact of 68Ga-PSMA PET/CT in a Patient With Biochemical Recurrence of Prostate Cancer.
A 64-year-old man with history of prostate adenocarcinoma underwent radical prostatectomy in 2003. He remained with undetectable prostate-specific antigen (PSA) levels until 2014, when he then presented rising serum PSA levels and performed a Tc-MDP bone scan that was negative for metastases. In August 2015, his PSA was 4.89 ng/dL, and restaging images with pelvic MR and F-FDG PET/CT were both negative. Therefore, the patient underwent a Ga-PSMA PET/CT that showed marked tracer uptake in a single mediastinal lymph node. Histopathology demonstrated metastatic adenocarcinoma secondary to prostate cancer, altering patient management to hormone therapy instead of pelvic radiotherapy.
From the *Division of Radiology, Sirio-Libanes Hospital, Sao Paulo; †Division of Nuclear Medicine, Sirio-Libanes Hospital, Sao Paulo; and ‡Medical Oncology Center, Sirio-Libanes Hospital, Sao Paulo, Brazil.
Marcelo A
MA
Queiroz
Publio
P
Viana
Allan
A
Santos
Diogo
D
Bastos
Elba
E
Etchebehere
Giovanni
G
Cerri
D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000556:secondary; D000954:Antigens, Surface; D019788:Fluorodeoxyglucose F18; D005710:Gallium Radioisotopes; D043425:Glutamate Carboxypeptidase II; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate
D000954:Antigens, Surface; D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II; D017430:Prostate-Specific Antigen; D013669:Technetium Tc 99m Medronate