Downregulated MicroRNA-133a in Gastric Juice as a Clinicopathological Biomarker for Gastric Cancer Screening.
Circulatory miR-133a is a marker shared by several types of cancer. In this study we evaluated the feasibility of using miR-133a levels in gastric juice to screen for gastric cancer. A total of 204 samples of gastric juice and mucosa from gastric cancer, atrophic gastritis, gastric ulcer, superficial gastritis and healthy cases were collected by gastroscopy. The results showed that miR-133a levels in gastric juice and carcinoma tissues of patients with gastric cancer were significantly downregulated and positively correlated. Moreover, miR-133a in gastric juice has high operability, high reliability, high sensitivity, high specificity and relative stability, fit for clinical diagnosis of gastric cancer.
Key Laboratory of Gerontology, Medical College, Yangzhou, Jiangsu, China E-mail : yzzzw@medmail.com.cn, shimyyz@126.com.
Juan
J
Shao
Peng-Hua
PH
Fang
Biao
B
He
Li-Li
LL
Guo
Ming-Yi
MY
Shi
Yan
Y
Zhu
Ping
P
Bo
Zhen-Wen
ZW
Zhen-Wen
D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D015536:Down-Regulation; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D005756:Gastritis / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D015203:Reproducibility of Results; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000235:genetics; D013276:Stomach Ulcer / Q000175:diagnosis* / Q000235:genetics
D014408:Biomarkers, Tumor; C548234:MIRN133 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger