Chemical Tools for Dissecting the Role of lncRNAs in Epigenetic Regulation.
Proper control and maintenance of gene expression is critical for cellular identity and maintenance. Transcription of RNA from the genome is intimately controlled by post-translational chemical modification of histone tails and DNA. Recent studies have demonstrated that chromatin-remodeling complexes seek out their target genomic loci through the help of noncoding RNA molecules. Within this Review, we will outline how the use of biochemical techniques has shed light on the mechanisms employed by RNA to guide these complexes and therefore control gene expression.
Department of Pharmaceutical Sciences, University of California , Irvine. Irvine, California 92697, United States.
Sarah
S
Nainar
Department of Pharmaceutical Sciences, University of California , Irvine. Irvine, California 92697, United States.
Chao
C
Feng
Department of Pharmaceutical Sciences, University of California , Irvine. Irvine, California 92697, United States.
Robert C
RC
Spitale
D044127:Epigenesis, Genetic / Q000502:physiology*; D015335:Molecular Probes; D009690:Nucleic Acid Conformation; D011506:Proteins / Q000737:chemistry; D062085:RNA, Long Noncoding / Q000737:chemistry / Q000502:physiology*
D015335:Molecular Probes; D011506:Proteins; D062085:RNA, Long Noncoding