APOBEC3G has the ability to programme T cell plasticity.
Recently Apolipoprotein B mRNA editing enzyme, Catalytic Polypeptide-like 3G (APOBEC3G) biology has assumed importance because of its role in oncogenesis. In this context, the present study was addressed to understand the immune-modulatory role of APOBEC3G through its effect upon the T-cell plasticity phenomenon. Such an attempt revealed that APOBEC3G has the inherent capacity to regulate genes coding for STAT3, NF-κB, CCL5, IL-6, IL-4, IFN-γ, IL-10 and IL-17 coupled with downregulation of Treg cells within human peripheral blood mononuclear cells (PBMCs) without any noticeable influence upon CD4(+) and CD8(+) cell number. On the basis of these findings, we propose that APOBEC3G has the ability to induce T cell plasticity and modulate immune response.
Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
Anuradha
A
Garg
Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India. Electronic address: dkaul235@gmail.com.
Deepak
D
Kaul
D000071480:APOBEC-3G Deaminase / Q000235:genetics / Q000502:physiology*; D000066670:Cell Plasticity; D005786:Gene Expression Regulation; D006801:Humans; D056747:Immunomodulation; D007378:Interleukins / Q000235:genetics; D016328:NF-kappa B / Q000235:genetics; D050796:STAT3 Transcription Factor / Q000235:genetics; D013601:T-Lymphocytes / Q000502:physiology*; D014162:Transfection
D007378:Interleukins; D016328:NF-kappa B; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D000071480:APOBEC-3G Deaminase
APOBEC3G; NF-κB; STAT3; T cell plasticity; Treg cells