Dynamic single gold nanoparticle visualization by clinical intracoronary optical coherence tomography.
The potential use of Gold Nanoparticles (GNPs) as contrast agents for clinical intracoronary frequency domain Optical Coherence Tomography (OCT) is here explored. The OCT contrast enhancement caused by GNPs of different sizes and morphologies has been systematically investigated and correlated with their optical properties. Among the different GNPs commercially available with plasmon resonances close to the operating wavelength of intracoronary OCT (1.3 µm), Gold Nanoshells (GNSs) have provided the best OCT contrast due to their largest scattering cross section at this wavelength. Clinical intracoronary OCT catheters are here demonstrated to be capable of three dimensional visualization and real-time tracking of individual GNSs. Results here included open an avenue to novel application of intravascular clinical OCT in combination with GNPs, such as real time evaluation of intravascular obstructions or pressure gradients.
Fluorescence Imaging Group, Departamento de Física de Materiales, Instituto Nicolás Cabrera, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
Jie
J
Hu
Cardiology Department, Hospital Universitario de la Princesa, IIS-IP, Universidad Autónoma de Madrid, Madrid.
Fernando
F
Rivero
Cardiology Department, Hospital Universitario de la Princesa, IIS-IP, Universidad Autónoma de Madrid, Madrid.
Rio Aguilar
RA
Torres
Facultad de Ciencias, Universidad Nacional de Ingeniería, P.O. Box 31-139, Lima, Perú.
Héctor
H
Loro Ramírez
Fluorescence Imaging Group, Departamento de Física de Materiales, Instituto Nicolás Cabrera, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049, Madrid, Spain.|Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Ramón y Cajal, 28034, Madrid, Spain.
Emma Martín
EM
Rodríguez
Cardiology Department, Hospital Universitario de la Princesa, IIS-IP, Universidad Autónoma de Madrid, Madrid.
Fernando
F
Alfonso
Fluorescence Imaging Group, Departamento de Física de Materiales, Instituto Nicolás Cabrera, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
José
J
García Solé
Fluorescence Imaging Group, Departamento de Física de Materiales, Instituto Nicolás Cabrera, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049, Madrid, Spain.|Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Ramón y Cajal, 28034, Madrid, Spain.
Daniel
D
Jaque
D003287:Contrast Media / Q000032:analysis; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D006046:Gold / Q000032:analysis*; D006801:Humans; D053768:Metal Nanoparticles / Q000032:analysis*; D041623:Tomography, Optical Coherence
D003287:Contrast Media; D006046:Gold
3D Imaging; Gold Nanoparticles; OCT intravascular imaging; Scattering