How inhibitory cues can both constrain and promote cell migration.
Collective cell migration is a common feature in both embryogenesis and metastasis. By coupling studies of neural crest migration in vivo and in vitro with mathematical modeling, Szabó et al. (2016, J. Cell Biol., http://dx.doi.org/10.1083/jcb.201602083) demonstrate that the proteoglycan versican forms a physical boundary that constrains neural crest cells to discrete streams, in turn facilitating their migration.
Division of Biology 139-74, California Institute of Technology, Pasadena, CA 91125 mbronner@caltech.edu.
Marianne E
ME
Bronner
D000818:Animals; D001001:Anura / Q000196:embryology; D002465:Cell Movement; D003463:Cues; D047108:Embryonic Development; D009432:Neural Crest / Q000166:cytology