Cross sectional, comparative study of serum erythropoietin, transferrin receptor, ferritin levels and other hematological indices in normal pregnancies and iron deficiency anemia during pregnancy.
OBJECTIVE
To test the correlation of the serum erythropoietin levels, serum transferrrin receptor levels and serum ferritin levels along with other hematological parameters in normal pregnant and anemic pregnant patients.


METHODS
In a prospective study, 120 pregnant women were recruited between 18 and 36 weeks of gestation; 53 normal pregnant patients, 67 anemic pregnant patients, in which, 17 had mild, 30 had moderate anemia, 20 had severe anemia. A blood sample was taken. The various hematological parameters, hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), total iron binding capacity (TIBC), serum ferritin, percentage saturation of iron, serum erythropoietin (SEPO) levels, serum transferrin receptors (STfRS) were performed. For statistics, Student's 't' test, Pearson's Chi test, Mann Whitney test and Bartlett test were used as per data.


CONCLUSIONS
MCV was significantly reduced in anemic pregnancies as compared to non-anemic pregnancies (80.2±9.6 vs 94.12±9.8fl, p=0.001), MCHC was also reduced in them (30.2±3.38% vs 34.2±2.33%, p=0.176), TIBC was significantly increased in anemic pregnancies (343.31±28.54% vs 322.88±23.84%, p=0.001), serum ferritin was significantly reduced (24.9±10.48μg/L vs 31.03±9.98μg/L, p=0.001), percentage saturation of iron was also reduced (53.85±13.21% vs 62.04±15.79%, p=0.0024), serum erythropoietin levels were significantly higher in anemic women (26.24±26.61mU/ml vs 18.12±19.08mU/ml, p=0.064). The levels were significantly higher in severe anemia (46.5±46.8mU/ml than in moderate anemia 27.4±28.1mU/ml and mild anemia 22.8±22.8mU/ml. Serum transferrin receptors were significantly higher in anemic pregnancies than in non-anemic pregnancies (1.40±0.0802μg/ml vs 1.08±0.641μg/ml, p=0.019) with rise being higher in severe anemia (2.28±0.986μg/ml) than in moderate (1.4±0.816μg/ml) and mild anemia (1.16±0.702μg/ml).


CONCLUSIONS
Various hematological parameters especially sTfR, serum erythropoietin, serum ferritin and sTfR/log ferritin levels correlate with the severity of anemia.
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India. Electronic address: jbsharma2000@gmail.com.
Jai B
JB
Sharma
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
Sirisha D
SD
Bumma
Department of Hematology, All India Institute of Medical Sciences, New Delhi, India.
Renu
R
Saxena
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
Sunesh
S
Kumar
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
Kallol K
KK
Roy
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
Neeta
N
Singh
Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
P
P
Vanamail
D000293:Adolescent; D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood*; D003430:Cross-Sectional Studies; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood*; D011446:Prospective Studies; D011990:Receptors, Transferrin / Q000097:blood*; D055815:Young Adult
D011990:Receptors, Transferrin; D004921:Erythropoietin; D005293:Ferritins
Blood indices; Iron deficiency anemia; Pregnancy; Serum erythropoietin levels; Serum transferrin receptor levels