Cardiac Affection in Type 1 Diabetic Patients in Relation to Omentin.
OBJECTIVE
To evaluate cardiac affection in type 1 diabetes in relation to Omentin.


METHODS
Sixty two diabetics and 30 volunteer of the same age and sex were included as a control group. Blood sample was taken for assessment of omentin and oxidized low density lipoprotein (OxLDL), glycosylated hemoglobin (HbA1) and lipid profile. Urine sample was taken for assessment of albumin/creatinine ratio. 24 hour holter was also done. T-test, simple correlation followed by stepwise multiple regression analysis was used for analysis of data.


RESULTS
Parameters of 24 hour holter were significantly lower in diabetics. Omentin was significantly lower, while OxLDL were significantly higher than controls. RMSSD, ST deviation and OxLDL were the parameters related to omentin by stepwise multiple regression analysis in diabetics.


CONCLUSIONS
Diabetic patients had a cardiac autonomic neuropathy. A significant reduction of omentin and elevation OxLDL imply that they influence glucose metabolism in type 1 diabetes. Omentin had a significant relation to 24 hr holter which may reflect its role in cardiac affection. Omentin and OxLDL had a role in renal affection.
Pediatrics Department, National Research Centre, Cairo, Egypt.
Soha M Abd El
SM
Dayem
Critical Care Department, Cairo University, Cairo, Egypt.
Ahmed A
AA
Battah
Cairo University, Medical Biochemistry, Cairo, Egypt.
Amal El
AE
Shehaby
24 hr holter; Cardiovascular; autonomic neuropathy; coronary calcification; type 1 diabetic patient