Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?
Evaluation of the pro versus antioxidant activity of ascorbate regarding Cu(Aβ) induced reactive oxygen species production in the context of Alzheimer's disease shows that a protective activity can only be observed at high ascorbate concentration for exogenous molecules but not for the amyloid-β peptide itself.
LCC (Laboratoire de Chimie de Coordination), CNRS UPR 8241, 205 route de Narbonne, 31062 Toulouse Cedex 09, France. christelle.hureau@lcc-toulouse.fr and Université de Toulouse; UPS, INPT, 31077 Toulouse, France and UMR 152 Pharma Dev, Université de Toulouse, IRD, UPS, France.
Clémence
C
Cheignon
LCC (Laboratoire de Chimie de Coordination), CNRS UPR 8241, 205 route de Narbonne, 31062 Toulouse Cedex 09, France. christelle.hureau@lcc-toulouse.fr and Université de Toulouse; UPS, INPT, 31077 Toulouse, France and UMR 152 Pharma Dev, Université de Toulouse, IRD, UPS, France.
Fabrice
F
Collin
LCC (Laboratoire de Chimie de Coordination), CNRS UPR 8241, 205 route de Narbonne, 31062 Toulouse Cedex 09, France. christelle.hureau@lcc-toulouse.fr and Université de Toulouse; UPS, INPT, 31077 Toulouse, France.
Peter
P
Faller
LCC (Laboratoire de Chimie de Coordination), CNRS UPR 8241, 205 route de Narbonne, 31062 Toulouse Cedex 09, France. christelle.hureau@lcc-toulouse.fr and Université de Toulouse; UPS, INPT, 31077 Toulouse, France.
Christelle
C
Hureau
D000544:Alzheimer Disease; D016229:Amyloid beta-Peptides; D000975:Antioxidants; D001205:Ascorbic Acid; D056831:Coordination Complexes; D003300:Copper; D003374:Coumarins; D018384:Oxidative Stress; D017382:Reactive Oxygen Species
D016229:Amyloid beta-Peptides; D000975:Antioxidants; D056831:Coordination Complexes; D003374:Coumarins; D017382:Reactive Oxygen Species; D003300:Copper; D001205:Ascorbic Acid; C104227:coumarin-3-carboxylic acid