Topical corticosteroids in dermatology.
Since their introduction, topical corticosteroids have become indispensable in the treatment of various dermatoses. Hydrocortisone was the first compound. Modifications in the basic structure generated in vivo activity and thus different topically active compounds were discovered. Apart from the Stoughton vasoconstrictor assay, various other methods are used for potency assessment of topical corticosteroids. Topical corticosteroides are classified based upon potency and action of these molecules. Mechanism of action at the cellular level and indications of topical corticosteroid use have been discussed. Various adverse effects often occur as an extension of their activity combined with inappropriate usage. Tachyphylaxis and contact allergy are potential problems in clinical practice. Newer compounds with improved risk-benefit ratio are available.
Department of Dermatology, D. Y. Patil School of Medicine, Navi Mumbai, Maharashtra, India.
Aayushi B
AB
Mehta
Department of Dermatology, D. Y. Patil School of Medicine, Navi Mumbai, Maharashtra, India.
Nitin J
NJ
Nadkarni
Department of Dermatology, D. Y. Patil School of Medicine, Navi Mumbai, Maharashtra, India.
Sharmila P
SP
Patil
Department of Dermatology, D. Y. Patil School of Medicine, Navi Mumbai, Maharashtra, India.
Kiran V
KV
Godse
Department of Dermatology, D. Y. Patil School of Medicine, Navi Mumbai, Maharashtra, India.
Manjyot
M
Gautam
Department of Dermatology, D. Y. Patil School of Medicine, Navi Mumbai, Maharashtra, India.
Shweta
S
Agarwal
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000517:prevention & control; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D003880:Dermatology / Q000379:methods* / Q000639:trends; D006801:Humans; D012871:Skin Diseases / Q000175:diagnosis / Q000188:drug therapy*
D000305:Adrenal Cortex Hormones; D003879:Dermatologic Agents