Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis.
Gastric cancer (GC) is a common cancer affecting patients around the world. The pathogenesis of gastric cancer has not been understood completely. Genetic mutations and the inflammation induced by Helicobacter pylori (HP) seem to play important roles. The cytokine Interleukin-4 (IL-4) has effects in inflammation, allergies and cancer including GC. The association of IL-4 -590 C>T polymorphism and gastric cancer has been studied in different populations with inconsistent results. Here, we report this meta-analysis showing that the polymorphism of IL-4 -590C>T might not be associated with the GC susceptibility in both Asian and Caucasian populations.
Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.
Tie
T
Wang
Department of Medical Education, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Lining
L
Tian
Department of General Surgery, The Forth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Meizhuo
M
Gao
Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.
Hongjiang
H
Song
Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.
Yuzhe
Y
Wei
Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.
Yingwei
Y
Xue
Gastric cancer; Interleukin-4; Meta-analysis; Polymorphism; Susceptibility