High field magnetic resonance imaging of rodents in cardiovascular research.
Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing specific investigation of cardiac anatomy, global and regional function, viability, perfusion or vascular parameters. The aim of this report is to provide a review of the various sequences and techniques available to image mice on 7-11.7 T magnets and relevant to the clinical setting in humans. Specific technical aspects due to the rise of the magnetic field are also discussed.
Department of Paediatric Cardiology, Cliniques universitaires Saint Luc, Université Catholique de Louvain (UCL), Brussels, Belgium. laetitia.vanhoutte@uclouvain.be.|Pole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium. laetitia.vanhoutte@uclouvain.be.
Laetitia
L
Vanhoutte
Division of Cardiology, Cliniques universitaires Saint Luc, Université Catholique de Louvain (UCL), Brussels, Belgium.|Pole of Cardiovascular Research (CARD), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium.
Bernhard L
BL
Gerber
Biomedical Magnetic Resonance Unit (REMA), Louvain Drug Research Institute (LDRI), Université Catholique de Louvain (UCL), Brussels, Belgium.
Bernard
B
Gallez
CNRS, ICube, FMTS, Institut de Physique Biologique, Faculté de Médecine, Université de Strasbourg, Strasbourg, France.
Chrystelle
C
Po
L'Institut de RYthmologie et de Modélisation Cardiaque (LIRYC), Inserm U1045, Bordeaux, France.
Julie
J
Magat
Pole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium.
Jean-Luc
JL
Balligand
Pole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium.
Olivier
O
Feron
Department of Paediatric Cardiology, Cliniques universitaires Saint Luc, Université Catholique de Louvain (UCL), Brussels, Belgium.
Stéphane
S
Moniotte
D000818:Animals; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging*; D004195:Disease Models, Animal; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice
Cardiovascular diseases; High field; MRI; Mouse