Comparison of NHANES III and ERS/GLI 12 for airway obstruction classification and severity.
The diagnosis and severity categorisation of obstructive lung disease is determined using reference values. The American Thoracic Society/European Respiratory Society in 2005 recommended the National Health and Nutrition Examination Survey (NHANES) III spirometry prediction equations for patients in USA aged 8-80 years. The Global Lung Initiative 2012 (GLI 12) provided spirometry prediction equations for patients aged 3-95 years. Comparison of the NHANES III and GLI 12 prediction equations for diagnosing and categorising airway obstruction in patients in USA has not been made.We aimed to quantify the differences between NHANES III and GLI 12 predicted values in Caucasians aged 18-95 years, using both mathematical simulation and clinical data. We compared predicted forced expiratory volume in 1 s (FEV1) and lower limit of normal (LLN) FEV1/forced vital capacity (FVC) % for NHANES III and GLI 12 prediction equations by applying both a simulation model and clinical spirometry data to quantify differences in the diagnosis and categorisation of airway obstruction.Mathematical simulation revealed significant similarities and differences between prediction equations for both LLN FEV1/FVC % and predicted FEV1 There are significant differences when using GLI 12 and NHANES III to diagnose airway obstruction and severity in Caucasian patients aged 18-95 years.Similarities and differences exist between NHANES III and GLI 12 for some age and height combinations. The differences in LLN FEV1/FVC % and predicted FEV1 are most prominent in older taller/shorter individuals. The magnitude of the differences can be large and may result in differences in clinical management.
Pulmonary and Critical Care Division, Dept of Medicine, Intermountain Medical Center, Salt Lake City, UT, USA Both authors contributed equally Olinto.linares@imail.org.
Olinto
O
Linares-Perdomo
Pulmonary and Critical Care Division, Dept of Medicine, Intermountain Medical Center, Salt Lake City, UT, USA University of Utah, School of Medicine, Salt Lake City, UT, USA Both authors contributed equally.
Matthew
M
Hegewald
Office of Research, Intermountain Healthcare, Salt Lake City, UT, USA.
Dave S
DS
Collingridge
Pulmonary and Critical Care Division, Dept of Medicine, Intermountain Medical Center, Salt Lake City, UT, USA University of Utah, School of Medicine, Salt Lake City, UT, USA.
Denitza
D
Blagev
Pulmonary and Critical Care Division, Dept of Medicine, Intermountain Medical Center, Salt Lake City, UT, USA University of Utah, School of Medicine, Salt Lake City, UT, USA.
Robert L
RL
Jensen
Hankinson Consulting, Inc., Athens, GA, USA.
John
J
Hankinson
Pulmonary and Critical Care Division, Dept of Medicine, Intermountain Medical Center, Salt Lake City, UT, USA University of Utah, School of Medicine, Salt Lake City, UT, USA.
Alan H
AH
Morris
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005060:Europe; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008173:Lung Diseases, Obstructive / Q000145:classification* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D012016:Reference Values; D012720:Severity of Illness Index; D013147:Spirometry; D013990:Tidal Volume; D014481:United States; D044465:White People; D055815:Young Adult