A facile one-step folic acid modified partially oxidized graphene for high sensitivity tumor cell sensing.
A highly sensitive and selective tumor cell sensor based on partially oxidized graphene (POG) and folate acid (FA) composite was constructed. The POG was prepared through a modified Hummers method and characterized by means of Raman spectroscopy, X-ray photoelectron spectroscopy, cyclic voltammetry, atomic force microscopy and transmission electron microscopy. The as-prepared POG exhibited the advantages of high electrochemical activity and a good capacity of linking amine derivatives. Using a facile one step reaction, the FA-modified POG was endowed with a more sensitive response to folate-expressing tumor cells than those sensors constructed by the two-step reaction, as well as high selectivity, good reproducibility and long-term stability.
School of Science, Beijing Jiaotong University, Beijing 100044, P R China. yuyu@bjtu.edu.cn dkjian@bjtu.edu.cn.
Wenyu
W
Gao
Qing
Q
Zheng
Zongxu
Z
Shen
Hao
H
Wu
Yuehui
Y
Ma
Weijun
W
Guan
Songmei
S
Wu
Yu
Y
Yu
Kejian
K
Ding
D000818:Animals; D015374:Biosensing Techniques; D016466:CHO Cells; D003412:Cricetulus; D058976:Folate Receptor 2 / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry*; D006108:Graphite; D006367:HeLa Cells; D006801:Humans; D046529:Microscopy, Electron, Transmission; D010084:Oxidation-Reduction; D015203:Reproducibility of Results
D058976:Folate Receptor 2; D006108:Graphite; D005492:Folic Acid