Anaphylaxis in laboratory workers because of rodent handling: two case reports.
BACKGROUND
Occupational allergy to rodents among laboratory animal workers is common. Most patients generally experience allergic symptoms after the first few years of work. Associated symptoms are usually mild, such as rhinoconjunctivits, urticaria, and asthma. Anaphylaxis, although rare, could be severe and life threatening.


METHODS
We have described in this study two cases of laboratory workers that developed skin and respiratory reactions following laboratory rat and mouse bites, consistent with anaphylaxis.


RESULTS
Skin testing was found positive for rat epithelium in the patient with anaphylaxis due to rat bite. Elevated levels of specific IgE antibodies against rat and mouse epitheliums were also detected in both the patients.


CONCLUSIONS
These cases illustrate a severe hypersensitivity reaction that could potentially occur in occupational workers that are in close contact with rodents. Reduction of allergen exposure, regular screening, and job modification could be beneficial for affected individuals. Health care workers should be made aware that anaphylaxis could be a serious consequence of laboratory animal bites, particularly in those already sensitized.
Division of Clinical Immunology and Allergy, Department of Medicine, St. Michael's Hospital University of Toronto.
Thatchai
T
Kampitak
Stephen D
SD
Betschel
D000062:Accidents, Occupational; D000328:Adult; D000707:Anaphylaxis / Q000209:etiology*; D017750:Animal Technicians; D000818:Animals; D000830:Animals, Laboratory; D001733:Bites and Stings / Q000150:complications*; D005260:Female; D006801:Humans; D017056:Medical Laboratory Personnel; D051379:Mice; D008875:Middle Aged; D051381:Rats; D012882:Skin Tests