Degradation products of mangiferin by gamma irradiation with inhibitory effects on NO production.
The xanthone glucoside mangiferin (1) was converted by γ-irradiation into three new compounds, mangiferdiol (2), mangiferinol (3), and isomangiferinol (4). The new compound 2 containing two hydroxymethyl groups instead of a ketone moiety exhibited significantly improved inhibitory activity against nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC50 value 47.1 ± 1.7 μM, compared to the mother mangiferin.
a Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science , Seoul National University , Seoul , Korea.
Cheorun
C
Jo
b Department of Food and Nutrition , Yeungnam University , Gyeongsan , Korea.
Kyung Young
KY
Yoon
b Department of Food and Nutrition , Yeungnam University , Gyeongsan , Korea.
Eun Jin
EJ
Jang
c Department of Food Science and Biotechnology , Daegu University , Gyeongsan , Korea.
Tae Hoon
TH
Kim
D000818:Animals; D005720:Gamma Rays; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis*; D000067996:RAW 264.7 Cells; D044004:Xanthones / Q000378:metabolism* / Q000494:pharmacology*
D008070:Lipopolysaccharides; D044004:Xanthones; C013592:mangiferin; D009569:Nitric Oxide
anti-inflammation; mangiferin degradation; nitiric oxide; γ-irradiation