N-Heterocyclic carbene-triggered transition-metal-free synthesis of 2,3-disubstituted benzofuran derivatives.
An NHC-triggered, transition-metal-free strategy for the efficient synthesis of 2,3-disubstituted benzofuran derivatives in moderate to excellent yields from aryl or alkyl aldehydes and o-quinone methides has been developed. This method features mild reaction conditions, operational simplicity, broad substrate scope and convergent assembly.
Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China. csyao@jsnu.edu.cn.
Yuanwei
Y
Xie
Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China. csyao@jsnu.edu.cn.
Chenxia
C
Yu
Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China. csyao@jsnu.edu.cn.
Yonglei
Y
Que
Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China. csyao@jsnu.edu.cn.
Tuanjie
T
Li
Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China. csyao@jsnu.edu.cn.
Yuhong
Y
Wang
Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China. csyao@jsnu.edu.cn.
Yinan
Y
Lu
Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China. csyao@jsnu.edu.cn.
Wenjing
W
Wang
Xuzhou Institute of Architectural Technology, Xuzhou, Jiangsu 221116, China.
Shide
S
Shen
Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116, P. R. China. csyao@jsnu.edu.cn.
Changsheng
C
Yao