[Molecular epidemiology of the lung cancer].
Lung cancers are common malignancies, which have a very poor prognosis. These are the leading cause of cancer deaths in France and worldwide. Behind this unfavourable prognosis hides many disparities according to age, sex, social level and exposure to risk factors. The detection of the genetic abnormalities, which drive carcinogenesis has totally changed the therapeutic approach. Tumours are now classified according to their molecular profile which is itself associated with new demographic data. We here review the most recent data on this topic.
Service de pneumologie, hôpital Larrey, CHU de Toulouse, université Paul-Sabatier, 31000 Toulouse, France.
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Guibert
Service de pneumologie, hôpital Larrey, CHU de Toulouse, université Paul-Sabatier, 31000 Toulouse, France.
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JD
Milia
Service de pneumologie, hôpital Larrey, CHU de Toulouse, université Paul-Sabatier, 31000 Toulouse, France. Electronic address: mazieres.j@chu-toulouse.fr.
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Mazieres
D000077548:Anaplastic Lymphoma Kinase; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D017720:Molecular Epidemiology; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics; D012307:Risk Factors
D000077548:Anaplastic Lymphoma Kinase; D066246:ErbB Receptors; D019869:Phosphatidylinositol 3-Kinases; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins; D048493:Proto-Oncogene Proteins B-raf; D016283:Proto-Oncogene Proteins p21(ras); D020794:Receptor Protein-Tyrosine Kinases; D018719:Erb-b2 Receptor Tyrosine Kinases; C117307:KRAS protein, human; C512478:EGFR protein, human; C508053:ERBB2 protein, human; C062333:ROS1 protein, human; C482119:BRAF protein, human
Biomarkers; Biomarqueurs; Cancer du poumon; Epidemiology; Lung cancer; Épidémiologie