Total pancreatectomy and islet cell autotransplantation: Definitive treatment for chronic pancreatitis.
In appropriately selected patients, total pancreatectomy and islet cell autotransplant controls pain and improves quality of life while often minimizing the development of overt diabetes. Multidisciplinary management and lifelong follow-up help to maximize the benefit of this procedure. This review highlights its history, indications, metabolic outcomes, and future directions.
Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH, USA.
Karla M
KM
Arce
Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH, USA.
Yu Kuei
YK
Lin
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA.|Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Tyler
T
Stevens
Department of General Surgery, Cleveland Clinic, Cleveland, OH, USA.|Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
R Matthew
RM
Walsh
Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, OH, USA. E-mail: hatipoglub@ccf.org.|Clinical Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Betul A
BA
Hatipoglu
D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D050500:Pancreatitis, Chronic / Q000601:surgery*; D014182:Transplantation, Autologous / Q000379:methods; D016896:Treatment Outcome