T2-prepared velocity selective labelling: A novel idea for full-brain mapping of oxygen saturation.
OBJECTIVE
Disturbances in cerebral oxygenation saturation (SO2) have been linked to adverse outcome in adults, children, and neonates. In intensive care, the cerebral SO2is increasingly being monitored by Near-InfraRed Spectroscopy (NIRS). Unfortunately NIRS has a limited penetration depth. The "modified T2-prepared Blood Imaging of Oxygen Saturation" (T2-BIOS) MR sequence provides a step towards full brain SO2measurement.


METHODS
Tissue SO2, and venous SO2(SvO2) were obtained simultaneously by T2-BIOS during a respiratory challenge in ten healthy volunteers. These two measures were compared to SO2that was obtained by a single probe MR-compatible NIRS setup, and to cerebral blood flow and venous SO2that were obtained by arterial spin labelling and T2-TRIR, respectively.


RESULTS
SO2-T2-BIOSand SO2-NIRShad a mean bias of -4.0% (95% CI -21.3% to 13.3%). SvO2-T2-BIOScorrelated with SO2-NIRS(R2=0.41, p=0.002) and SvO2-T2-TRIR(R2=0.87, p=0.002). In addition, SO2-NIRScorrelated with SvO2-T2-TRIR(R2=0.85, p=0.003) Frontal cerebral blood flow correlated with SO2-T2-BIOS(R2=0.21, p=0.04), but was not significant in relation to SO2-NIRS.


CONCLUSIONS
Full brain SO2assessment by any technique may help validating NIRS and may prove useful in guiding the clinical management of patient populations with cerebral injury following hypoxic-ischaemic events. The agreement between NIRS and T2-BIOS provides confidence in measuring cerebral SO2by either technique. As it stands now, the T2-BIOS represents a novel idea and future work will focus on improvements to make it a reliable tool for SO2assessment.
Department of Neonatology, Wilhelmina Children's Hospital/University Medical Center Utrecht, Room KE04.123.1, PO Box 85090, 3584 AE, Utrecht, The Netherlands. Electronic address: t.alderliesten-3@umcutrecht.nl.
Thomas
T
Alderliesten
Department of Neonatology, Wilhelmina Children's Hospital/University Medical Center Utrecht, Room KE04.123.1, PO Box 85090, 3584 AE, Utrecht, The Netherlands. Electronic address: J.deVis-2@umcutrecht.nl.
Jill B
JB
De Vis
Department of Neonatology, Wilhelmina Children's Hospital/University Medical Center Utrecht, Room KE04.123.1, PO Box 85090, 3584 AE, Utrecht, The Netherlands. Electronic address: p.lemmers@umcutrecht.nl.
Petra M A
PMA
Lemmers
Department of Neonatology, Wilhelmina Children's Hospital/University Medical Center Utrecht, Room KE04.123.1, PO Box 85090, 3584 AE, Utrecht, The Netherlands. Electronic address: f.vanbel@umcutrecht.nl.
Frank
F
van Bel
Department of Neonatology, Wilhelmina Children's Hospital/University Medical Center Utrecht, Room KE04.123.1, PO Box 85090, 3584 AE, Utrecht, The Netherlands. Electronic address: manonbenders@gmail.com.
Manon J N L
MJNL
Benders
Department of Radiology,University Medical Center Utrecht, Room: E.01.132, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. Electronic address: j.hendrikse@umcutrecht.nl.
Jeroen
J
Hendrikse
Department of Radiology,University Medical Center Utrecht, Room: E.01.132, P.O. Box 85500, 3508 GA Utrecht, The Netherlands; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark. Electronic address: Esben.thade.petersen@gmail.com.
Esben T
ET
Petersen
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping / Q000379:methods*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D057054:Molecular Imaging; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013194:Staining and Labeling
D010100:Oxygen
Adults; Cerebral oxygenation; Near-Infrared Spectroscopy; Respiratory challenge