Periodontitis and systemic lupus erythematosus.
A large number of studies have shown a potential association between periodontal and autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus (SLE). Similar mechanisms of tissue destruction concerning periodontitis and other autoimmune diseases have stimulated the study of a possible relationship between these conditions. This study aims to review the literature about this potential association and their different pathogenic mechanisms. Considering that periodontal disease is a disease characterized by inflammation influenced by infectious factors, such as SLE, it is plausible to suggest that SLE would influence periodontal disease and vice versa. However, this issue is not yet fully elucidated and several mechanisms have been proposed to explain this association, as deregulation mainly in innate immune system, with action of phagocytic cells and proinflammatory cytokines such as IL-1β and IL-18 in both conditions' pathogenesis, leading to tissue destruction. However, studies assessing the relationship between these diseases are scarce, and more studies focused on common immunological mechanisms should be conducted to further understanding.
Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil. Electronic address: manuela_rubim@hotmail.com.
Manuela Rubim Camara
MR
Sete
Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.
Carlos Marcelo da Silva
CM
Figueredo
Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; Division of Pediatric Rheumatology, Instituto de Puericultura e Pediatria Martagão Gesteira (IPPMG), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; Sector of Rheumatology, Núcleo de Estudos da Saúde do Adolescente (NESA), Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.
Flavio
F
Sztajnbok
D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology* / Q000378:metabolism; D010510:Periodontal Diseases; D010518:Periodontitis / Q000453:epidemiology* / Q000378:metabolism
D016207:Cytokines
Immunology; Imunologia; Lúpus eritematoso sistêmico; Periodontite; Periodontitis; Systemic lupus erythematosus