Pharmaceutical Applications of Electrospraying.
The electrohydrodynamic atomization technique, or simply called electrospraying, has been extensively studied for biomedical as well as for pharmaceutical applications over the past years. The simplicity, flexibility, and efficiency of producing particles at the microscale or nanoscale, with tailored size, shape, morphology, and microstructure, make electrospraying to become one of the most promising and well-practiced approaches to be applied in many biomedical and pharmaceutical fields, from improving the bioavailability of poorly aqueous soluble drugs, preparing targeted drug delivery systems, and controllable drug release systems to delivering sensitive therapeutic agents such as protein-based drugs or even living cells. Nevertheless, some issues still remain with respect to low throughput as well as the complex interplay between a great number of processing and formulation factors. A comprehensive understanding of these fundamental aspects is essential for the successful application of electrospraying for the production of particulate formulations with desired properties.
Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven-University of Leuven, Leuven B-300, Belgium.
Duong Nhat
DN
Nguyen
Department of Chemical Engineering, KU Leuven-University of Leuven, Leuven B-3001, Belgium.
Christian
C
Clasen
Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven-University of Leuven, Leuven B-300, Belgium. Electronic address: guy.vandenmooter@pharm.kuleuven.be.
Guy
G
Van den Mooter
D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D055664:Electrochemical Techniques / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties
D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D011108:Polymers
amorphous; controlled release; delivery systems; drug delivery systems; formulation; microspheres; nanoparticles; physicochemical properties; polymeric drug; processing