Scalable procedure for the fragmentation of hydroperoxides mediated by copper and iron tetrafluoroborate salts.
An improved protocol for the formal elimination of propene from organic substrates is reported. This process entails the ozonolytic conversion of an alkene to a methoxy hydroperoxide which undergoes fragmentation mediated by copper and iron. The use of soluble Cu(BF4)2 and Fe(BF4)2 results in reproducible results up to a 100 gram scale.
Department of Chemistry, Yale University, 275 Prospect St., New Haven, CT 06520-8107, USA. timothy.newhouse@yale.edu.
David
D
Huang
Alexander W
AW
Schuppe
Michael Z
MZ
Liang
Timothy R
TR
Newhouse