Transcranial Direct Current Stimulation Effects on Semantic Processing in Healthy Individuals.
Semantic processing allows us to use conceptual knowledge about the world. It has been associated with a large distributed neural network that includes the frontal, temporal and parietal cortices. Recent studies using transcranial direct current stimulation (tDCS) also contributed at investigating semantic processing.



The goal of this article was to review studies investigating semantic processing in healthy individuals with tDCS and discuss findings from these studies in line with neuroimaging results. Based on functional magnetic resonance imaging studies assessing semantic processing, we predicted that tDCS applied over the inferior frontal gyrus, middle temporal gyrus, and posterior parietal cortex will impact semantic processing.



We conducted a search on Pubmed and selected 27 articles in which tDCS was used to modulate semantic processing in healthy subjects. We analysed each article according to these criteria: demographic information, experimental outcomes assessing semantic processing, study design, and effects of tDCS on semantic processes.



From the 27 reviewed studies, 8 found main effects of stimulation. In addition to these 8 studies, 17 studies reported an interaction between stimulus types and stimulation conditions (e.g. incoherent functional, but not instrumental, actions were processed faster when anodal tDCS was applied over the posterior parietal cortex as compared to sham tDCS). Results suggest that regions in the frontal, temporal, and parietal cortices are involved in semantic processing.



tDCS can modulate some aspects of semantic processing and provide information on the functional roles of brain regions involved in this cognitive process.
Centre interdisciplinaire de recherche en réadaptation et en intégration sociale, 525, Boul. Wilfrid-Hamel, Bureau H-1312, Québec (QC), Canada, G1M 2S8; Centre de recherche de l'Institut universitaire en santé mentale de Québec, 2601, de la Canardière, Québec (QC), Canada, G1J 2G3; Faculté de médecine, Université Laval, 1050, avenue de la Médecine, Québec (QC), Canada, G1V 0A6.
Marilyne
M
Joyal
Centre interdisciplinaire de recherche en réadaptation et en intégration sociale, 525, Boul. Wilfrid-Hamel, Bureau H-1312, Québec (QC), Canada, G1M 2S8; Centre de recherche de l'Institut universitaire en santé mentale de Québec, 2601, de la Canardière, Québec (QC), Canada, G1J 2G3; Faculté de médecine, Université Laval, 1050, avenue de la Médecine, Québec (QC), Canada, G1V 0A6. Electronic address: shirley.fecteau@fmed.ulaval.ca.
Shirley
S
Fecteau
D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D059906:Neuroimaging; D012660:Semantics; D065908:Transcranial Direct Current Stimulation / Q000379:methods*
Language; Semantic processing; Transcranial direct current stimulation (tDCS)