Self-assembled IR780-loaded transferrin nanoparticles as an imaging, targeting and PDT/PTT agent for cancer therapy.
Combination of photothermal and photodynamic therapy (PTT/PDT) offer unique advantages over PDT alone. However, to achieve synergetic PDT/PTT effect, one generally needs two lasers with different wavelengths. Near-infrared dye IR-780 could be used as photosensitizer both for PTT and PDT, but its lipophilicity limits its practical use and in vivo efficiency. Herein, a simple multifunctional IR780-loaded nanoplatform based on transferrin was developed for targeted imaging and phototherapy of cancer compatible with a single-NIR-laser irradiation. The self-assembled transferrin-IR780 nanoparticles (Tf-IR780 NPs) exhibited narrow size distribution, good photo-stability, and encouraging photothermal performance with enhanced generation of ROS under laser irradiation. Following intravenous injection, Tf-IR780 NPs had a high tumor-to-background ratio in CT26 tumor-bearing mice. Treatment with Tf-IR780 NPs resulted in significant tumor suppression. Overall, the Tf-IR780 NPs show notable targeting and theranostic potential in cancer therapy.
State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing 210093, China.|State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Kaikai
K
Wang
State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing 210093, China.
Yifan
Y
Zhang
State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing 210093, China.
Juan
J
Wang
State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing 210093, China.
Ahu
A
Yuan
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Minjie
M
Sun
State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing 210093, China.|State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.|Institute of Drug R, Medical School of Nanjing University, Nanjing 210093, China.|Jiangsu R Platform for Controlled &Targeted Drug Delivery, Nanjing University, Nanjing 210093, China.
Jinhui
J
Wu
State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing 210093, China.|Institute of Drug R, Medical School of Nanjing University, Nanjing 210093, China.|Jiangsu R Platform for Controlled &Targeted Drug Delivery, Nanjing University, Nanjing 210093, China.
Yiqiao
Y
Hu
D000818:Animals; D006979:Hyperthermia, Induced / Q000379:methods*; D007211:Indoles / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy*; D010778:Photochemotherapy; D010789:Phototherapy / Q000379:methods*; D013056:Spectrophotometry, Ultraviolet; D014168:Transferrin / Q000737:chemistry*
C548458:2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium; D007211:Indoles; D014168:Transferrin