Profile of the Paraoxonase 1 (PON1) Gene 192Q/R Polymorphism and Clinical Associations among Older Singaporean Chinese with Alzheimer's and Mixed Dementia.
BACKGROUND
To examine the prevalence of the Paraoxonase1 (PON1) gene 192Q/R polymorphism amongst Singaporean Chinese with Alzheimer's disease (AD) and mixed dementia and possible clinical associations.


METHODS
We examined the presence of the PON1 192Q/R polymorphism together with cognitive status, functional status and neuropsychiatric symptoms among 186 older Singaporean Chinese with AD (n = 109) and mixed dementia (n = 77).


RESULTS
The R allele predominated in 67% of the AD patients and 63.1% of the patients with mixed dementia. Within the mixed dementia subgroup, the R allele was significantly associated with a higher BADLS score, NPI-Q scores and CDR scores.


CONCLUSIONS
Among older Singaporean Chinese with AD and mixed dementia, the R allele was predominant. In particular, within the mixed dementia subgroup, the R allele carrier status was associated with poorer functional status, greater presence of neuropsychiatric symptoms and a more severe stage of dementia. Further studies should be conducted.
Geriatric Medicine, Singapore General Hospital, SingHealth, Singapore.
Dennis C C
DC
Seow
Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Psychological Medicine, National University Health System, Singapore.
Qi
Q
Gao
Geriatric Medicine, Khoo Teck Puat Hospital, Alexandra Health, Singapore.
Philip
P
Yap
Institute of Medical Biology, ASTAR/Singapore OncoGenome Laboratory, Singapore.
Jia Min
JM
Gan
Nursing, Khoo Teck Puat Hospital, Alexandra Health, Singapore.
Hui Ling
HL
Chionh
Endocrinology, Khoo Teck Puat Hospital, Alexandra Health, Singapore.
Su Chi
SC
Lim
Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Psychological Medicine, National University Health System, Singapore.
Lei
L
Feng
Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Psychological Medicine, National University Health System, Singapore.
Tze Pin
TP
Ng
Alzheimer's disease; Mixed dementia; Neuropsychiatric symptoms; Paraoxonase 1; Singaporean Chinese elderly