Salvia divinorum: toxicological aspects and analysis in human biological specimens.
The identification and quantitation of the main psychoactive component of Salvia divinorum (salvinorin A) in biological specimens are crucial in forensic and clinical toxicology. Despite all the efforts made, its uncontrolled abuse has increased quickly, exposing its users' health to serious risks both in the short and long term. The use of alternative biological matrices in toxicological analyzes can be advantageous as complementary postmortem samples, or in situations when neither blood nor urine can be collected; they may be useful tools in those determinations, providing important information about prior exposure. The aim of this article is to present a brief summary of legal aspects of Salvia divinorum and salvinorin A, including the methods used for the determination of the latter in biological matrices.
Instituto Nacional de Medicina Legal e Ciências Forenses, I.P. (INMLCF, I.P.) - Delegação do Centro, Coimbra, Portugal.
Cláudia
C
Margalho
Instituto Nacional de Medicina Legal e Ciências Forenses, I.P. (INMLCF, I.P.) - Delegação do Centro, Coimbra, Portugal.|Faculdade de Medicina, Universidade de Coimbra, Portugal.
Francisco
F
Corte-Real
Servicio de Toxicología Forense, Instituto Universitario de Ciencias Forenses, Universidad de Santiago de Compostela, Spain.
Manuel
M
López-Rivadulla
Centro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Portugal.|Laboratório de Fármaco-Toxicologia - UBIMedical, Universidade da Beira Interior, Covilhã, Portugal.
Eugenia
E
Gallardo
D045785:Diterpenes, Clerodane / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity / Q000652:urine; D006197:Hair / Q000378:metabolism; D006213:Hallucinogens / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity / Q000652:urine; D006801:Humans; D000069236:Pericardial Fluid / Q000378:metabolism; D012463:Saliva / Q000378:metabolism; D027544:Salvia / Q000737:chemistry* / Q000145:classification; D013542:Sweat / Q000378:metabolism; D014822:Vitreous Body / Q000378:metabolism
D045785:Diterpenes, Clerodane; D006213:Hallucinogens; C090499:salvinorin A
Salvia divinorum; analytical methodologies; salvinorin A