Association between anxiety state and mitral valve disorders: A Taiwanese population-wide observational study.
OBJECTIVE
Despite substantial research progress in concurrent diseases, for instance comorbidities involving anxiety state (AS) and mitral valve disorders (MVD), the current measures and care are limited and no consensus about their association has yet been reached. Hence, this study aims to analyze the prevalence and association between AS and MVD among Taiwanese population.


METHODS
We employed phenome-wide association study (PWAS) portal to investigate the association between AS and MVD using claim data of Taiwan's National Health Insurance Research Database (NHIRD) from year 2000 to 2002. Association strength between AS and MVD was analyzed among overall age and gender groups.


RESULTS
We found an overall stronger association between AS and MVD, which was significantly higher in younger age group (OR 15, 95% CI 14.82-16.88) than in the elderly age group (OR 1.99, 95% CI 1.76-2.24). Also, the study reveals a higher incidence of co-occurrence in females than males, particularly in age group of 40-49.


CONCLUSIONS
Based on our results showing considerable strength of association between AS and MVD, this study suggests the necessity of MVD assessment in all patients with AS, particularly in younger females. Moreover, we also propose psychotherapeutic as well as pharmacologic intervention for comorbidity-based pathologies to better the quality care for high-need Taiwanese population.
Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
Navneet Kumar
NK
Dubey
Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Shabbir
S
Syed-Abdul
Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Phung Anh
PA
Nguyen
Freelance Writer, Taipei, Taiwan.
Rajni
R
Dubey
Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Usman
U
Iqbal
Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Yu-Chuan
YC
Li
Stem Cell Research Center, Taipei Medical University, Taipei, Taiwan.
Wei-Hong
WH
Chen
Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Stem Cell Research Center, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Basic Medicine, Fu-Jen Catholic University, Taipei, Taiwan. Electronic address: wpdeng@tmu.edu.tw.
Win-Ping
WP
Deng
D000328:Adult; D001007:Anxiety / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008945:Mitral Valve Prolapse / Q000150:complications*; D013624:Taiwan
Anxiety; Comorbidity; Mitral valve disorders