A Cap for Every Occasion: Alternative eIF4F Complexes.
The eukaryotic translation initiation factor 4F (eIF4F) has become essentially synonymous with 5' cap-dependent mRNA translation. Recent studies demonstrate that cells assemble variants of eIF4F to produce adaptive, cap-dependent translatomes during physiological conditions that inhibit eIF4F. These findings challenge us to reassess classical perceptions of cellular translational pathways.
Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 31336, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 31336, USA.
J J David
JJD
Ho
Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 31336, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 31336, USA. Electronic address: stephenlee@med.miami.edu.
Stephen
S
Lee
D000818:Animals; D039561:Eukaryotic Initiation Factor-4E / Q000235:genetics* / Q000378:metabolism; D039562:Eukaryotic Initiation Factor-4F / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D014176:Protein Biosynthesis; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D012315:RNA Caps / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D012568:Schizosaccharomyces / Q000235:genetics* / Q000378:metabolism; D014351:Trypanosomatina / Q000235:genetics* / Q000378:metabolism
D039561:Eukaryotic Initiation Factor-4E; D039562:Eukaryotic Initiation Factor-4F; D010750:Phosphoproteins; D020033:Protein Isoforms; D012315:RNA Caps; D012333:RNA, Messenger
eIF4E; eIF4E2; eIF4F; eIF4G3; hypoxia; translation