Risk of major depressive disorder among older persons living in HIV-endemic central and southwestern Uganda.
Major depressive disorder (MDD) is projected to become the second most common cause of disability by 2020 calling for a better understanding its antecedents across the lifespan and in diverse socio-cultural settings. In this paper we describe the risk factors of MDD among older people (50 years +) living in HIV-endemic central and southwestern Uganda. A cross-sectional study was undertaken among 471 respondents (50 years +) participating in the Wellbeing of Older People's Study cohort of the MRC/UVRI Uganda research Unit on AIDS in Uganda. Participants were from five strata: HIV negative, HIV positive on ART, HIV positive not on ART, having an adult child on ART, and having an adult child who died of HIV. Overall MDD prevalence was 9.2% (95% CI 6.7-12.2%) with a prevalence among males of 7.4% (95% CI 4.0-12.3%) and females of 10.3% (95% CI 7.0-14.3%). Factors significantly associated with MDD included: declining socio-economic status, increasing disability scores, decreasing mean grip strength, reported back pain, and not having hypertension. Marginally associated with MDD was being HIV infected and not on ART.
a Medical Research Council/Uganda Virus Research Institute , Entebbe , Uganda.|b Department of Psychiatry , Makerere College of Health Sciences , Kampala , Uganda.|c Department of Infectious Disease Epidemiology , London School of Hygiene and Tropical Medicine , London , UK.
Eugene
E
Kinyanda
a Medical Research Council/Uganda Virus Research Institute , Entebbe , Uganda.
Monica
M
Kuteesa
a Medical Research Council/Uganda Virus Research Institute , Entebbe , Uganda.
Francien
F
Scholten
a Medical Research Council/Uganda Virus Research Institute , Entebbe , Uganda.
Joseph
J
Mugisha
c Department of Infectious Disease Epidemiology , London School of Hygiene and Tropical Medicine , London , UK.
Kathy
K
Baisley
a Medical Research Council/Uganda Virus Research Institute , Entebbe , Uganda.|c Department of Infectious Disease Epidemiology , London School of Hygiene and Tropical Medicine , London , UK.
Janet
J
Seeley
D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use; D001416:Back Pain / Q000453:epidemiology / Q000523:psychology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000453:epidemiology*; D006233:Persons with Disabilities / Q000523:psychology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000523:psychology; D018737:Hand Strength; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D012923:Social Class; D011795:Surveys and Questionnaires; D014454:Uganda / Q000453:epidemiology
D019380:Anti-HIV Agents
Africa; HIV-endemic settings; Major depressive disorder; older people; risk factors