Hepatoprotective pyranocoumarins from the stems of Clausena emarginata.
Seven pyranocoumarins, clauemarmarins A-G, along with 6 known analogues were isolated from the stems of Clausena emarginata. Their structures were elucidated by extensive spectroscopic analyses, and the absolute stereochemistries at C-6″ of clauemarmarin B, C and D and the absolute configurations of clauemarmarin E, F and G were determined by ECD experiments. Compounds clauemarmarin C, D and two known analogues exhibited hepatoprotective activities against DL-galactosamine-induced damage in WB-F344 cells at the concentration of 10 μM.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Taishan Scholar-Distinguished Experts Position, Key Disciplines on Analysis of Traditional Chinese Medicine, Shandong Key Laboratory of Chinese Medicine Quality Standard Research, Shandong Academy of Chinese Medicine, Jinan, 250014, China.
Hong-Min
HM
Xia
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Chuang-Jun
CJ
Li
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Jing-Zhi
JZ
Yang
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Jie
J
Ma
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Yan
Y
Li
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Li
L
Li
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: zhangdm@imm.ac.cn.
Dong-Ming
DM
Zhang
D000470:Alkaloids / Q000737:chemistry; D054700:Clausena / Q000737:chemistry*; D005688:Galactosamine / Q000494:pharmacology; D008099:Liver / Q000187:drug effects*; D018547:Plant Stems / Q000737:chemistry*; D039681:Pyranocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000470:Alkaloids; D039681:Pyranocoumarins; D005688:Galactosamine
Clauemarmarins A−G; Clausena emarginata; Hepatoprotective activity; Pyranocoumarins; Rutaceae