Effect of Topical Platelet-Rich Plasma on Burn Healing After Partial-Thickness Burn Injury.
BACKGROUND To investigate the effects of platelet-rich plasma on tissue maturation and burn healing in an experimental partial-thickness burn injury model. MATERIAL AND METHODS Thirty Wistar albino rats were divided into 3 groups of 10 rats each. Group 1 (platelet-rich plasma group) was exposed to burn injury and topical platelet-rich plasma was applied. Group 2 (control group) was exposed to burn injury only. Group 3 (blood donor group) was used as blood donors for platelet-rich plasma. The rats were killed on the seventh day after burn injury. Tissue hydroxyproline levels were measured and histopathologic changes were examined. RESULTS Hydroxyproline levels were significantly higher in the platelet-rich plasma group than in the control group (P=.03). Histopathologically, there was significantly less inflammatory cell infiltration (P=.005) and there were no statistically significant differences between groups in fibroblast development, collagen production, vessel proliferations, or epithelization. CONCLUSIONS Platelet-rich plasma seems to partially improve burn healing in this experimental burn injury model. As an initial conclusion, it appears that platelet-rich plasma can be used in humans, although further studies should be performed with this type of treatment.
Department of General Surgery, Baskent University School of Medicine, Istanbul Training and Research Hospital, Istanbul, Turkey.
Umit
U
Ozcelik
Department of General Surgery, Baskent University, Ankara, Turkey.
Yahya
Y
Ekici
Department of General Surgery, Baskent University School of Medicine, Istanbul Training and Research Hospital, Istanbul, Turkey.
Huseyin Yuce
HY
Bircan
Department of General Surgery, Baskent University, Ankara, Turkey.
Cem
C
Aydogan
Department of General Surgery, Baskent University, Ankara, Turkey.
Suna
S
Turkoglu
Department of General Surgery, Baskent University, Ankara, Turkey.
Ozlem
O
Ozen
Department of General Surgery, Baskent University, Ankara, Turkey.
Gokhan
G
Moray
Department of General Surgery, Baskent University, Ankara, Turkey.
Mehmet
M
Haberal
D000818:Animals; D002056:Burns / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D004195:Disease Models, Animal; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D053657:Platelet-Rich Plasma; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing
D006909:Hydroxyproline