New Approaches in Locoregional Therapies for Hepatocellular Carcinoma.
OBJECTIVE
Hepatocellular carcinoma (HCC) represent actually the fifth most common cancer worldwide, with liver transplantation and hepatic resection who represent the standard of care of curative treatment. Unfortunately, not all patient could benefit of curative treatment. For such patients, locoregional or systemic therapies represent a valid option in order to achieve the best survival possible.


METHODS
A review of most interesting paper actually present in literature on locoregional treatment for nonresectable nontransplantable HCC was performed.


RESULTS
A detailed description on each different approach has been detailed in each chapter.


CONCLUSIONS
In case of nontransplantable and nonresectable HCC, locoregional treatment represent a valid alternative in management of this patients.
Department of Digestive Surgery, University Hospital of Strasbourg, IRCAD, Research Institute Against Cancer of the Digestive Tract, IHU-Strasbourg, Institute for Image-Guided Surgery, 1, place de l'Hôpital, 67091, Strasbourg, France. riccardo.memeo@chru-strasbourg.fr.|Inserm U1110, Institut de Recherche sur les Maladies Virale et Hepatiques, Strasbourg, France. riccardo.memeo@chru-strasbourg.fr.
Riccardo
R
Memeo
Department of Digestive Surgery, University Hospital of Strasbourg, IRCAD, Research Institute Against Cancer of the Digestive Tract, IHU-Strasbourg, Institute for Image-Guided Surgery, 1, place de l'Hôpital, 67091, Strasbourg, France.
Vito
V
de Blasi
Department of Digestive Surgery, University Hospital of Strasbourg, IRCAD, Research Institute Against Cancer of the Digestive Tract, IHU-Strasbourg, Institute for Image-Guided Surgery, 1, place de l'Hôpital, 67091, Strasbourg, France.
Zineb
Z
Cherkaoui
Department of Digestive Surgery, University Hospital of Strasbourg, IRCAD, Research Institute Against Cancer of the Digestive Tract, IHU-Strasbourg, Institute for Image-Guided Surgery, 1, place de l'Hôpital, 67091, Strasbourg, France.
Ammar
A
Dehlawi
Unit of Digestive, Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Henri Mondor Hospital, AP-HP, Université Paris Est-UPEC, 51, Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
Nicola
N
De' Angelis
Service de Chirurgie Générale, Digestive et Endocrinienne, Hôpital Robert Debré, Centre Hospitalier Universitaire de Reims, Université de Reims Champagne-Ardenne, Reims, France.
Tullio
T
Piardi
Service de Chirurgie Générale, Digestive et Endocrinienne, Hôpital Robert Debré, Centre Hospitalier Universitaire de Reims, Université de Reims Champagne-Ardenne, Reims, France.
Daniele
D
Sommacale
Department of Digestive Surgery, University Hospital of Strasbourg, IRCAD, Research Institute Against Cancer of the Digestive Tract, IHU-Strasbourg, Institute for Image-Guided Surgery, 1, place de l'Hôpital, 67091, Strasbourg, France.
Jacques
J
Marescaux
Department of Digestive Surgery, University Hospital of Strasbourg, IRCAD, Research Institute Against Cancer of the Digestive Tract, IHU-Strasbourg, Institute for Image-Guided Surgery, 1, place de l'Hôpital, 67091, Strasbourg, France.
Didier
D
Mutter
Department of Digestive Surgery, University Hospital of Strasbourg, IRCAD, Research Institute Against Cancer of the Digestive Tract, IHU-Strasbourg, Institute for Image-Guided Surgery, 1, place de l'Hôpital, 67091, Strasbourg, France.|Inserm U1110, Institut de Recherche sur les Maladies Virale et Hepatiques, Strasbourg, France.
Patrick
P
Pessaux
D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy*; D010166:Palliative Care / Q000379:methods
Hepatocellular carcinoma; Locoregional treatment; Palliative treatment