A Pro-metastatic tRNA Pathway.
tRNAs are best known as basic modules for global regulation of protein synthesis. Goodarzi et al. now show that two tRNAs upregulated in metastatic breast cancer cells enhance stability and translation of transcripts enriched with these codons, leading to specific increase in production of pro-metastatic proteins.
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Canan
C
Kuscu
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address: ad8q@virginia.edu.
Anindya
A
Dutta
D003062:Codon; D006801:Humans; D014176:Protein Biosynthesis; D012343:RNA, Transfer / Q000235:genetics*
D003062:Codon; D012343:RNA, Transfer