Iridium-Catalyzed Synthesis of Acylpyridines by [2 + 2 + 2] Cycloaddition of Diynes with Acyl Cyanides.
2-Acylpyridines were prepared by iridium-catalyzed [2 + 2 + 2] cycloaddition of α,ω-diynes with acyl cyanides. [Ir(cod)Cl]2/rac-BINAP or F-DPPE is an efficient catalyst for this reaction. The scope and limitations of this reaction have been disclosed.
Department of Chemistry and Biological Science, Aoyama Gakuin University , 5-10-1 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5258, Japan.
Toru
T
Hashimoto
Department of Chemistry and Biological Science, Aoyama Gakuin University , 5-10-1 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5258, Japan.
Kaoru
K
Kato
Department of Chemistry and Biological Science, Aoyama Gakuin University , 5-10-1 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5258, Japan.
Reiko
R
Yano
Department of Chemistry and Biological Science, Aoyama Gakuin University , 5-10-1 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5258, Japan.
Tomoki
T
Natori
Department of Chemistry and Biological Science, Aoyama Gakuin University , 5-10-1 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5258, Japan.
Hiroki
H
Miura
Department of Chemistry and Biological Science, Aoyama Gakuin University , 5-10-1 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5258, Japan.
Ryo
R
Takeuchi