Hypercalcemia in a Dog with Chronic Ingestion of Maxacalcitol Ointment.
A miniature dachshund male with severe azotemia of unknown cause was referred. Serum biochemistry revealed severe azotemia and hypercalcemia, but serum intact parathormone and parathormone-related protein were normal. Although the owner reported that the dog had never ingested any drugs or supplements, it was revealed that the owner's son used antipsoriatic ointment, maxacalcitol, which contained an active vitamin D3 analogue, daily and the dog often ate the son's dander and licked his skin, especially after he applied the maxacalcitol ointment. After the dog was insulated from the maxacalcitol ointment and the son as much as possible, the hypercalcemia and azotemia improved gradually and had mostly resolved at 3 mo. The dog has been generally free of clinical signs without any treatment for over 2 yr.
From the Veterinary Teaching Hospital, Department of Veterinary Clinical Sciences (K.N., N.T., K.M.) and Laboratory of Veterinary Internal Medicine (H.O., M.T.), Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan; and the Laboratory of Veterinary Small Animal Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate, Japan (M.Y.).
Kensuke
K
Nakamura
From the Veterinary Teaching Hospital, Department of Veterinary Clinical Sciences (K.N., N.T., K.M.) and Laboratory of Veterinary Internal Medicine (H.O., M.T.), Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan; and the Laboratory of Veterinary Small Animal Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate, Japan (M.Y.).
Nobuo
N
Tohyama
From the Veterinary Teaching Hospital, Department of Veterinary Clinical Sciences (K.N., N.T., K.M.) and Laboratory of Veterinary Internal Medicine (H.O., M.T.), Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan; and the Laboratory of Veterinary Small Animal Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate, Japan (M.Y.).
Masahiro
M
Yamasaki
From the Veterinary Teaching Hospital, Department of Veterinary Clinical Sciences (K.N., N.T., K.M.) and Laboratory of Veterinary Internal Medicine (H.O., M.T.), Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan; and the Laboratory of Veterinary Small Animal Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate, Japan (M.Y.).
Hiroshi
H
Ohta
From the Veterinary Teaching Hospital, Department of Veterinary Clinical Sciences (K.N., N.T., K.M.) and Laboratory of Veterinary Internal Medicine (H.O., M.T.), Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan; and the Laboratory of Veterinary Small Animal Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate, Japan (M.Y.).
Keitaro
K
Morishita
From the Veterinary Teaching Hospital, Department of Veterinary Clinical Sciences (K.N., N.T., K.M.) and Laboratory of Veterinary Internal Medicine (H.O., M.T.), Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan; and the Laboratory of Veterinary Small Animal Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate, Japan (M.Y.).
Mitsuyoshi
M
Takiguchi
D000818:Animals; D002117:Calcitriol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D004283:Dog Diseases / Q000139:chemically induced* / Q000175:diagnosis; D004285:Dogs; D006934:Hypercalcemia / Q000139:chemically induced / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D009824:Ointments
D009824:Ointments; D002117:Calcitriol; C051883:maxacalcitol