Spectral-Domain Optical Coherence Tomography Features in Open-Angle Glaucoma With Diabetes Mellitus and Inadequate Glycemic Control.
To evaluate spectral-domain optical coherence tomography (SD-OCT) features according to glycemic control status in open-angle glaucoma with diabetes mellitus.



Subjects underwent comprehensive ocular examination, visual field testing, and SD-OCT imaging (Cirrus HD-OCT). The relationship between glycosylated hemoglobin (HbA1c) and OCT measurements was compared between diabetic nonglaucomatous eyes and diabetic glaucomatous eyes. Glaucoma-discriminating ability was assessed using the area under the receiver operating characteristic curves (AUCs) for OCT parameters and compared between groups relative to the glycemic control group.



Analysis was performed on 69 nonglaucomatous and 87 glaucomatous eyes in the nondiabetic group, and on 72 nonglaucomatous and 56 glaucomatous eyes in the diabetic group. Average, inferonasal, inferior, and inferotemporal ganglion cell-inner plexiform layer (GCIPL) thicknesses were positively correlated with HbA1c in diabetic nonglaucomatous eyes (P = 0.040, 0.037, 0.025, and 0.013, respectively). The AUC of the average cup-to-disc area ratio (CDR), vertical CDR, and cup volume in diabetic eyes with poor glycemic control was significantly higher than those in nondiabetic eyes (P = 0.011, 0.003, and 0.043, respectively). The AUC of cube volume, cube average thickness, and minimal GCIPL thickness in diabetic eyes with poor glycemic control was lower than those in nondiabetic eyes (P = 0.006, 0.007, and 0.004, respectively).



In this study, optic nerve head parameters had a superior ability to discriminate glaucoma in diabetic eyes with poor glycemic control. Conversely, the ability to discriminate glaucoma using macular parameters tended to be lower for diabetic eyes with inadequate glycemic control.
Department of Ophthalmology and Inha Vision Science Laboratory Inha University School of Medicine, Incheon, Republic of Korea.
So Yeon
SY
Jeong
Department of Ophthalmology and Inha Vision Science Laboratory Inha University School of Medicine, Incheon, Republic of Korea.
Sang Jun
SJ
Park
Department of Ophthalmology and Inha Vision Science Laboratory Inha University School of Medicine, Incheon, Republic of Korea.
Hee Seung
HS
Chin
Department of Endocrinology, Inha University School of Medicine, Incheon, Republic of Korea.
So Hun
SH
Kim
Department of Ophthalmology and Inha Vision Science Laboratory Inha University School of Medicine, Incheon, Republic of Korea.
Na Rae
NR
Kim
D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000175:diagnosis; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000000981:diagnostic imaging*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008266:Macula Lutea / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000000981:diagnostic imaging; D041623:Tomography, Optical Coherence / Q000379:methods
D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human