Prediction of Gut Wall Integrity Loss in Viral Gastroenteritis by Non-Invasive Marker.
BACKGROUND
Intestinal fatty acid binding proteins (I-FABPs) are mainly expressed in the intestinal villi, which are the initial site of destruction in viral gastroenteritis.


OBJECTIVE
This study was designed to assess serum I-FABPs as a predictor of gut wall integrity loss in viral gastroenteritis.


METHODS
This case-control cross-sectional study was conducted on 93 cases of acute viral gastroenteritis. Twenty-eight healthy children matching in age were recruited as control group. Serum I-FABPs were measured using ELISA technique. Viral detection and typing were done by PCR for adenovirus, and by Reverse transcriptase PCR for rotavirus, astrovirus and norovirus.


RESULTS
Serum I-FABPs level was significantly higher in the cases compared to the controls and was also higher in the 46 rotavirus gastroenteritis cases compared to other viral gastroenteritis cases. Serum I- FABPs level was significantly higher in severely dehydrated cases as compared to mildly dehydrated ones (P=0.037).


CONCLUSIONS
Serum I-FABPs could be used as an early and sensitive predictor marker of gut wall integrity loss in children with viral gastroenteritis and its level can indicate case severity.
Child Health Department, National Research Centre, Cairo, Egypt.
Hala G
HG
Elnady
Child Health Department, National Research Centre, Cairo, Egypt.
Lobna S
LS
Sherif
Child Health Department, National Research Centre, Cairo, Egypt.
Maysa T
MT
Saleh
Child Health Department, National Research Centre, Cairo, Egypt.
Inas R
IR
El-Alameey
Child Health Department, National Research Centre, Cairo, Egypt.
Mai M
MM
Youssef
Health Radiation Research Department, National Centre for Radiation Research and Technology, Cairo, Egypt.
Amal I
AI
El Shafie
Immunogenetics Department, National Research Centre, Cairo, Egypt.
Iman
I
Helwa
Immunogenetics Department, National Research Centre, Cairo, Egypt.
Haiam Abdel
HA
Raouf
Environment Virology Laboratory and Water Pollution Department, National Research Centre, Cairo, Egypt.
Ahmed N
AN
El-Taweel
Gut Wall Integrity Loss; Non Invasive Marker; Predicition; Viral Gastroenteritis