Role of β-Adrenoceptors and L-Type Ca(2+)-Channels in the Mechanism of Reperfusion-Induced Heart Injury.
We studied the effects of β-adrenoceptor antagonists propranolol and nadolol and L-type Ca(2+)-channel blocker verapamil on cardiac reperfusion injury developed after 45-min coronary occlusion. The substances were injected intravenously 5 min before reperfusion. The results indicate that activation of β-adrenoceptors and opening of L-type Ca(2+)-channels promote the development of cardiac reperfusion injury, while blockage of β-adrenoceptors and/or L-type Ca(2+)-channels prevents reoxygenation-induced myocardial injury. Propranolol, nadolol, and verapamil can produce infraction-limiting effects after onset of ischemic heart injury.
Research Institute of Cardiology, Tomsk, Russia.
Yu B
YB
Lishmanov
Research Institute of Cardiology, Tomsk, Russia. maslov@cardio-tomsk.ru.
L N
LN
Maslov
Research Institute of Cardiology, Tomsk, Russia.
A V
AV
Mukhomedzyanov
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D020746:Calcium Channels, L-Type / Q000378:metabolism*; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009248:Nadolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D014700:Verapamil / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D020746:Calcium Channels, L-Type; D011943:Receptors, Adrenergic, beta; D009248:Nadolol; D011433:Propranolol; D014700:Verapamil
Ca2+ -channels; heart; postconditioning; reperfusion; β-adreneric receptors