Predictive Value of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Patients with Coronary Slow Flow.
BACKGROUND
Increased microvascular resistance due to chronic inflammation is assumed to be one of the mechanisms associated with coronary slow flow (CSF). Previous studies have shown that the platelet-to-lymphocyte ratio (PLR) and the neutrophil-lymphocyte ratio (NLR) are markers of inflammation for various diseases. In this study we aimed to evaluate the relationship between CSF and PLR-NLR.


METHODS
Seventy-eight patients with CSF and 50 patients with normal coronary flow were enrolled into this study. The study subjects underwent medical examination and testing, after which their platelet-to-lymphocyte ratios and NLR values were calculated. An independent observer measured the coronary flow rate by Thrombolysis in Myocardial Infarction Frame Count (TFC) method. The platelet-to-lymphocyte ratio and NLR values were compared between the groups and correlation analysis was performed to explore the relationship between mean TFC with PLR and NLR.


RESULTS
Platelet-to-lymphocyte ratio and NLR values were significantly higher in patients with CSF (p < 0.001). There was a positive significant correlation between TFC with NLR and PLR (Spearman's Rho: 0.59, p < 0.001 and Spearman's Rho: 0.30, p = 0.001, respectively). Multivariate logistic regression analysis revealed that NLR is the one independent predictor for CSF.


CONCLUSIONS
This study demonstrated an association between CSF and PLR-NLR. Although the exact mechanism could not be explained, our findings support the possible role of inflammation in CSF physiopathology.
Department of Cardiology, Ankara Numune Education and Research Hospital;
Mustafa
M
Çetin
Department of Cardiology, Ankara Numune Education and Research Hospital;
Emrullah
E
Kiziltunc
Department of Cardiology, Ankara Numune Education and Research Hospital;
Özgül Uçar
ÖU
Elalmış
Department of Cardiology, Ankara Numune Education and Research Hospital;
Zehra Güven
ZG
Çetin
Department of Cardiology, Turgut Özal University School of Medicine;
Muhammed Bora
MB
Demirçelik
Department of Cardiology, Ankara Numune Education and Research Hospital;
Hülya
H
Çiçekçioğlu
Department of Cardiology, Ankara Education and Research Hospital;
Alparslan
A
Kurtul
Department of Cardiology, Ankara Keçiören Education and Research Hospital.
Selçuk
S
Özkan
Department of Cardiology, Ankara Numune Education and Research Hospital;
Candan Mansuroğlu
CM
Avan
Department of Cardiology, Ankara Numune Education and Research Hospital;
Ender
E
Örnek
Department of Cardiology, Ankara Numune Education and Research Hospital;
Feridun Vasfi
FV
Ulusoy
Coronary slow flow; Inflammation; Neutrophil lymphocyte ratio; Platelet lymphocyte ratio