Biological Activity of Polynesian Calophyllum inophyllum Oil Extract on Human Skin Cells.
Oil from the nuts of Calophyllum inophyllum, locally called "Tamanu oil" in French Polynesia, was traditionally used for wound healing and to cure various skin problems and ailments. The skin-active effect of "Tamanu oil emulsion" was investigated on human skin cells (keratinocytes and dermal fibroblasts) and showed cell proliferation, glycosaminoglycan and collagen production, and wound healing activity. Transcriptomic analysis of the treated cells revealed gene expression modulation including genes involved in the metabolic process implied in O-glycan biosynthesis, cell adhesion, and cell proliferation. The presence of neoflavonoids as bioactive constituents in Tamanu oil emulsion may contribute to these biological activities. Altogether, consistent data related to targeted histological and cellular functions brought new highlights on the mechanisms involved in these biological processes induced by Tamanu oil effects in skin cells.
Université de la Polynésie Française, Faa'a, Tahiti, Polynésie Française.
Jean-Luc
JL
Ansel
Centre de Biophysique Moléculaire, Orléans, France.
Elise
E
Lupo
Centre de Biophysique Moléculaire, Orléans, France.
Lily
L
Mijouin
Interfaces, Confinement, Matériaux et Nanostructures (ICMN), Université d'Orléans, CNRS, UMR 7374, Orléans, France.
Samuel
S
Guillot
Consultant en foresterie et botanique polynésienne, Pirae, Tahiti, Polynésie Française.
Jean-François
JF
Butaud
Université de la Polynésie Française, Faa'a, Tahiti, Polynésie Française.
Raimana
R
Ho
Université de Versailles Saint-Quentin en Yvelines, Versailles, France.
Gaël
G
Lecellier
Université de la Polynésie Française, Faa'a, Tahiti, Polynésie Française.
Phila
P
Raharivelomanana
Centre de Biophysique Moléculaire, Orléans, France.
Chantal
C
Pichon
D029759:Calophyllum / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects; D002461:Cell Line, Transformed; D003094:Collagen / Q000096:biosynthesis; D006025:Glycosaminoglycans / Q000378:metabolism; D015603:Keratinocytes / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D012867:Skin / Q000166:cytology / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects
D006025:Glycosaminoglycans; D010936:Plant Extracts; D010938:Plant Oils; D003094:Collagen