Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women.
Coffee consumption has been reported to reduce the risk of type 2 diabetes in experimental and epidemiological studies. This anti-diabetic effect of coffee may be attributed to its high content in polyphenols especially caffeic acid and chlorogenic acid. However, the association between plasma coffee polyphenols and diabetic risks has never been investigated in the literature. In this study, fasting plasma samples were collected from 57 generally healthy females aged 38-73 (mean 52, s.d. 8) years recruited in Himeji, Japan. The concentrations of plasma coffee polyphenols were determined by liquid chromatography coupled with mass tandem spectrometer. Diabetes biomarkers in the plasma/serum samples were analysed by a commercial diagnostic laboratory. Statistical associations were assessed using Spearman's correlation coefficients. The results showed that plasma chlorogenic acid exhibited negative associations with fasting blood glucose, glycated hemoglobin and C-reactive protein, whereas plasma total coffee polyphenol and plasma caffeic acid were weakly associated with these biomarkers. Our preliminary data support previous findings that coffee polyphenols have anti-diabetic effects but further replications with large samples of both genders are recommended.
School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.
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Lee
School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.
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Tan
School of Human Science and Environment, University of Hyogo, Himeji, Japan.
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N
Hiramatsu
School of Human Science and Environment, University of Hyogo, Himeji, Japan.
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A
Ishisaka
School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.
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Alfonso
Nutrition Clinic, Kagawa Nutrition University, Tokyo, Japan.
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A
Tanaka
School of Human Science and Environment, University of Hyogo, Himeji, Japan.
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N
Uemura
School of Human Science and Environment, University of Hyogo, Himeji, Japan.
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Y
Fujiwara
School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.|Nutrition Clinic, Kagawa Nutrition University, Tokyo, Japan.|Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia.
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http://orcid.org/0000-0001-6359-3382
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Takechi
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein; D002109:Caffeic Acids / Q000097:blood*; D002726:Chlorogenic Acid / Q000097:blood*; D003069:Coffee / Q000737:chemistry; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D012306:Risk
D015415:Biomarkers; D002097:C-Reactive Protein; D002109:Caffeic Acids; D002726:Chlorogenic Acid; D003069:Coffee; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human; C040048:caffeic acid