Assessment of Prognostic Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Patients with Pulmonary Embolism.
BACKGROUND
Acute pulmonary embolism is a serious medical condition that has a substantial global impact. Inflammation plays a role in the pathophysiology and prognosis of acute pulmonary embolism (APE). The aim of the present study was to investigate the prognostic value of admission parameters for complete blood count (CBC) in APE.


METHODS
A total of 203 patients who were hospitalized with diagnosed APE were retrospectively enrolled in the study. Clinical data, PESI scores, admission CBC parameters, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were all recorded. The clinical outcomes of study subjects were determined by the reported patient 30-day mortality and long-term mortality.


RESULTS
During a median follow-up period of 20 months [interquantile range 17], 34 subjects in the study population (17%) died. NLR and PLR levels were significantly higher in patients who died within the 30 days (n = 14) [9.9 (5.5) vs. 4.5 (4.1), p = 0.01 and 280 (74) vs. 135 (75), p = 0.01, respectively] and during the long-term follow-up (n = 20) [8.4 (2.9) vs. 4.1 (3.8), p = 0.01 and 153 (117) vs. 133 (73), p = 0.03, respectively] when compared to the patients that survived. In Cox regression analysis, age, systolic blood pressure, systolic pulmonary arterial pressure, PESI scores (HR 1.02 95%CI 1.01-1.04, p = 0.01), elevated levels of NLR (HR 1.13 95%CI 1.04-1.23, p = 0.01) and PLR (HR 1.002 95%CI 1.001-1.004, p = 0.01) were independently correlated with total mortality.


CONCLUSIONS
Admission NLR and PLR may have prognostic value in patients with APE.
Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center;
Mehmet Baran
MB
Karataş
Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center;
Göktürk
G
İpek
Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center;
Tolga
T
Onuk
Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center;
Barış
B
Güngör
Department of Cardiology, Arnavutköy State Hospital;
Gündüz
G
Durmuş
Department of Cardiology, Kartal Yavuz Selim State Hospital, Istanbul, Turkey.
Yiğit
Y
Çanga
Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center;
Yasin
Y
Çakıllı
Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center;
Osman
O
Bolca
Mortality; Pulmonary embolism