The Outcome of Large B-Cell Lymphoma Evolving in a Hematopoietic Stem Cell Transplant Patient During Treatment of Chronic Graft-Versus-Host Disease.
Immunosuppression is a risk factor for the development of posttransplant lymphoproliferative disorder. This type of malignancy developed in an immunocompromised man. The patient presented with focal convulsion starting from right face and right arm followed by two generalized convulsions with one minute interval. Diagnosis was made by computed tomographic (CT) scan of the cranium following oral and intravenous administration of contrast dyes which revealedmass leisons in the frontotemporal lobe and by stereotaxic biopsy. Tissue sections showed a malignant tumor cell infiltration with large areas of necrosis and many mitoses. Many tumor cells were positive for CD 20 and CD 10. These findings were consistent with large B-cell lymphoma. Central nervous system radiation with a dose of 56 Gy was given with clinical and radiological improvement. The patient died due to multiorgan failure. Finally, the immunocompromised patients should be closely followed for the development of lymphoproliferative disorder.
Sevgi
S
Kalayoğlu Beşışık
Orhan
O
Kocaman
Burak
B
Erer
Mustafa
M
Yenerel
Öner
Ö
Doğan
Deniz
D
Sargın