Holding the Inflammatory System in Check: TLRs and Their Targeted Therapy in Asthma.
Inflammation is a complex biological response to detrimental stimuli and can be a double-edged sword. Inflammation plays a protective role in removing pathogenic factors, but dysregulated inflammation is associated with several major fatal diseases such as asthma, cancer, and cardiovascular diseases. Asthma is a complex heterogenous disease caused by genetic and environmental factors. TLRs are the primary proteins associated with the innate and adaptive immune responses to these fatal factors and play an important role in recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), which initiates the downstream immune response. Due to the complex TLRs cascade and nowadays unsuccessful control in asthma, new studies are focused on TLRs and other potential targets in TLR cascade to minimize airway inflammation.
Department of Pathogen Biology, Basic Medical College, Jilin University, Changchun 130021, China.
Zhiyong
Z
Dong
Department of Pathogen Biology, Basic Medical College, Jilin University, Changchun 130021, China.
Lingxin
L
Xiong
Department of Respiratory Disease, Jilin Provincial People's Hospital, Changchun 130021, China.
Weijie
W
Zhang
Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW 2305, Australia.
Peter G
0000-0001-5865-489X
PG
Gibson
Department of Pathogen Biology, Basic Medical College, Jilin University, Changchun 130021, China.
Ting
T
Wang
Department of Pathogen Biology, Basic Medical College, Jilin University, Changchun 130021, China.
Yanjiao
Y
Lu
Department of Pathogen Biology, Basic Medical College, Jilin University, Changchun 130021, China.
Guoqiang
G
Wang
Department of Respiratory Disease, Jilin Provincial People's Hospital, Changchun 130021, China.
Hui
H
Li
Department of Pathogen Biology, Basic Medical College, Jilin University, Changchun 130021, China.
Fang
F
Wang
D000818:Animals; D001249:Asthma / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D000069452:Pathogen-Associated Molecular Pattern Molecules / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D051193:Toll-Like Receptors / Q000378:metabolism*
D000069452:Pathogen-Associated Molecular Pattern Molecules; D051193:Toll-Like Receptors