Retina regeneration in zebrafish.
Unlike mammals, zebrafish are able to regenerate a damaged retina. Key to this regenerative response are Müller glia that respond to retinal injury by undergoing a reprogramming event that allows them to divide and generate a retinal progenitor that is multipotent and responsible for regenerating all major retinal neuron types. The fish and mammalian retina are composed of similar cell types with conserved function. Because of this it is anticipated that studies of retina regeneration in fish may suggest strategies for stimulating Müller glia reprogramming and retina regeneration in mammals. In this review we describe recent advances and future directions in retina regeneration research using zebrafish as a model system.
Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, United States.
Jin
J
Wan
Molecular and Behavioral Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: neuroman@umich.edu.
Daniel
D
Goldman
D000818:Animals; D030801:Animals, Genetically Modified; D002454:Cell Differentiation / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics*; D006801:Humans; D009416:Nerve Regeneration / Q000235:genetics*; D009457:Neuroglia / Q000378:metabolism; D012160:Retina / Q000254:growth & development* / Q000293:injuries / Q000473:pathology; D013234:Stem Cells / Q000378:metabolism; D015027:Zebrafish / Q000235:genetics / Q000254:growth & development