Mathematical analysis of multi-antibiotic resistance.
BACKGROUND
Multi-antibiotic resistance in bacterial infections is a growing threat to public health. Some experiments were carried out to study the multi-antibiotic resistance.


METHODS
The changes of the multi-antibiotic resistance with time were achieved by numerical simulations and the mathematical models, with the calculated temperature field, velocity field, and the antibiotic concentration field.


RESULTS
The computed results and experimental results are compared.


CONCLUSIONS
Both numerical simulations and the analytic models suggest that minor low concentrations of antibiotics could induce antibiotic resistance in bacteria.
College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China; College of Science, Northwest A&F University, Yangling, Shaanxi, China. Electronic address: zhaobin835@nwsuaf.edu.cn.
Bin
B
Zhao
College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China. Electronic address: zhang.xy@nwsuaf.edu.cn.
Xiaoying
X
Zhang
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008962:Models, Theoretical
D000900:Anti-Bacterial Agents
Mathematical model; Multi-antibiotic resistance; Numerical simulation