Biodegradable Mg-Cu alloys with enhanced osteogenesis, angiogenesis, and long-lasting antibacterial effects.
A series of biodegradable Mg-Cu alloys is designed to induce osteogenesis, stimulate angiogenesis, and provide long-lasting antibacterial performance at the same time. The Mg-Cu alloys with precipitated Mg2Cu intermetallic phases exhibit accelerated degradation in the physiological environment due to galvanic corrosion and the alkaline environment combined with Cu release endows the Mg-Cu alloys with prolonged antibacterial effects. In addition to no cytotoxicity towards HUVECs and MC3T3-E1 cells, the Mg-Cu alloys, particularly Mg-0.03Cu, enhance the cell viability, alkaline phosphatase activity, matrix mineralization, collagen secretion, osteogenesis-related gene and protein expressions of MC3T3-E1 cells, cell proliferation, migration, endothelial tubule forming, angiogenesis-related gene, and protein expressions of HUVECs compared to pure Mg. The favorable osteogenesis and angiogenesis are believed to arise from the release of bioactive Mg and Cu ions into the biological environment and the biodegradable Mg-Cu alloys with osteogenesis, angiogenesis, and long-term antibacterial ability are very promising in orthopedic applications.
Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China.|Department of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing, China.|Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Chen
C
Liu
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Xuekun
X
Fu
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Haobo
H
Pan
Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China.
Peng
P
Wan
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Lei
L
Wang
Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China.
Lili
L
Tan
Department of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing, China.
Kehong
K
Wang
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Ying
Y
Zhao
Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China.
Ke
K
Yang
Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Hong Kong, China.
Paul K
PK
Chu
D016475:3T3 Cells; D000497:Alloys / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D005786:Gene Expression Regulation / Q000187:drug effects; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008274:Magnesium / Q000737:chemistry*; D051379:Mice; D008826:Microbial Sensitivity Tests; D018919:Neovascularization, Physiologic / Q000235:genetics; D010012:Osteogenesis / Q000235:genetics; D013211:Staphylococcus aureus / Q000187:drug effects
D000497:Alloys; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D003300:Copper; D008274:Magnesium