Expression of VEGFR and PDGFR-α/-β in 187 canine nasal carcinomas.
Radiotherapy represents the standard of care for intranasal carcinomas. Responses to tyrosine kinase inhibitors (TKIs) have been reported but data on expression of target receptor tyrosine kinases (rTKs) is limited. This study characterizes the expression of vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR)-α and PDGFR-β in canine intranasal carcinomas. Histological samples from 187 dogs were retrieved. Immunohistochemistry was performed using commercially available antibodies. Expression of rTKs was classified into weak, moderate or intense and additionally recorded as cytoplasmic, membranous, cytoplasmic-membranous, nuclear or stromal. VEGFR was expressed in 158 dogs with predominantly moderate expression (36.9%) and a cytoplasmic-membranous expression pattern (70.9%). PDGFR-α was detected in 133 with predominantly weak expression (57.9%) and cytoplasmic pattern (87.9%). PDGFR-β was identified in 74 patients with a predominantly moderate expression (17.6%) and cytoplasmic expression pattern (63.5%). Co-expression of rTKs was common. These results confirm expression of VEGFR, PDGFR-α and PDGFR-β in canine intranasal carcinomas and support the utility of TKIs.
Small Animal Teaching Hospital, Leahurst Campus, University of Liverpool, Neston CH64 7TE, United Kingdom.
I
I
Gramer
Small Animal Teaching Hospital, Leahurst Campus, University of Liverpool, Neston CH64 7TE, United Kingdom.
D
D
Killick
Bridge Pathology Ltd., Bristol BS7 0BJ, UK.
T
T
Scase
Bridge Pathology Ltd., Bristol BS7 0BJ, UK.
D
D
Chandry
Small Animal Teaching Hospital, Leahurst Campus, University of Liverpool, Neston CH64 7TE, United Kingdom.
M
M
Marrington
Small Animal Teaching Hospital, Leahurst Campus, University of Liverpool, Neston CH64 7TE, United Kingdom.
L
L
Blackwood
D000818:Animals; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D005260:Female; D008297:Male; D009669:Nose Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000378:metabolism*; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000378:metabolism*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism*; D046888:Tissue Array Analysis / Q000662:veterinary
D020796:Receptor, Platelet-Derived Growth Factor alpha; D020797:Receptor, Platelet-Derived Growth Factor beta; D040262:Receptors, Vascular Endothelial Growth Factor
PDGFR-α; PDGFR-β; TKI; VEGFR; dog; nasal carcinoma