Quality of life in adolescents and adults with CHARGE syndrome.
Health-related Quality of Life and the Impact of Childhood Neurologic Disability Scale were collected for 53 patients with CHARGE syndrome aged 13-39 years with a mean academic level of 4th grade. The most prevalent new and ongoing issues included bone health issues, sleep apnea, retinal detachment, anxiety, and aggression. Sleep issues were significantly correlated with anxiety, self-abuse, conduct problems, and autistic-like behaviors. Problems with overall health, behavior, and balance most affected the number of social activities in the individual's life. Sensory impairment most affected relationships with friends. Two contrasting case studies are presented and demonstrate that the quality of life exists on a broad spectrum in CHARGE syndrome, just as its physical features range from mild to very severe. A multitude of factors, including those beyond the physical manifestations, such as anxiety and sleep problems, influence quality of life and are important areas for intervention. © 2016 Wiley Periodicals, Inc.
Social Sciences Division, Delta College, University Center, Michigan.
Nancy
N
Hartshorne
Dalhousie Medical School, Halifax, Nova Scotia, Canada.
Alexandra
A
Hudson
Dalhousie Medical School, Halifax, Nova Scotia, Canada.
Jillian
J
MacCuspie
Department of Psychology, Central Michigan University, Mount Pleasant, Michigan.
Benjamin
B
Kennert
Department of Psychology, Central Michigan University, Mount Pleasant, Michigan.
Tasha
T
Nacarato
Department of Psychology, Central Michigan University, Mount Pleasant, Michigan.
Timothy
T
Hartshorne
Department of Pediatrics, IWK Health Centre, Dalhousie University, Nova Scotia, Canada.
Kim
K
Blake
D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D001519:Behavior; D058747:CHARGE Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010641:Phenotype; D010808:Physical Examination; D015995:Prevalence; D011788:Quality of Life; D012307:Risk Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
CHARGE syndrome; adolescent; adult; development; quality of life