How Our Other Genome Controls Our Epi-Genome.
Eukaryotes and prokaryotes produce extracellular nanovescicles that contain RNAs and other molecules that they exploit to communicate. Recently, inter-kingdom crosstalk was demonstrated between humans and bacteria through fecal microRNAs. We suggest here how bacteria interact with humans via RNAs within membrane vesicles to alter our epigenome, thus filling the gap and closing the circle. At the same time, there are indications that there could be a wider inter-kingdom communication network that might encompass all known kingdoms. Now that the connection with our other genome has been established, we also should begin to explore the 'social' network that we have around us.
Bambino Gesù Children's Hospital-IRCCS, Gene Expression-Microarrays Laboratory, Viale di San Paolo 15, 00146, Rome, Italy.
Antonella
A
Celluzzi
Bambino Gesù Children's Hospital-IRCCS, Gene Expression-Microarrays Laboratory, Viale di San Paolo 15, 00146, Rome, Italy. Electronic address: andrea.masotti@opbg.net.
Andrea
A
Masotti
D001419:Bacteria / Q000235:genetics* / Q000378:metabolism; D021961:Cell Membrane Structures / Q000502:physiology; D044127:Epigenesis, Genetic; D056890:Eukaryota / Q000235:genetics; D055354:Exosomes / Q000235:genetics; D000067128:Extracellular Vesicles / Q000378:metabolism*; D000069196:Gastrointestinal Microbiome; D015894:Genome, Human; D006801:Humans; D012329:RNA, Bacterial / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics
D012329:RNA, Bacterial; D022661:RNA, Untranslated
epigenetics; exosomes; gut microbiota; non-coding RNAs; outer-membrane vesicles