Engineered matrices for skeletal muscle satellite cell engraftment and function.
Regeneration of traumatically injured skeletal muscles is severely limited. Moreover, the regenerative capacity of skeletal muscle declines with aging, further exacerbating the problem. Recent evidence supports that delivery of muscle satellite cells to the injured muscles enhances muscle regeneration and reverses features of aging, including reduction in muscle mass and regenerative capacity. However, direct delivery of satellite cells presents a challenge at a translational level due to inflammation and donor cell death, motivating the need to develop engineered matrices for muscle satellite cell delivery. This review will highlight important aspects of satellite cell and their niche biology in the context of muscle regeneration, and examine recent progresses in the development of engineered cell delivery matrices designed for skeletal muscle regeneration. Understanding the interactions of muscle satellite cells and their niche in both native and engineered systems is crucial to developing muscle pathology-specific cell- and biomaterial-based therapies.
Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, United States; Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, United States.
Woojin M
WM
Han
Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, United States; School of Applied Physiology, Georgia Institute of Technology, Atlanta, GA, United States.
Young C
YC
Jang
Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, United States; Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, United States. Electronic address: andres.garcia@me.gatech.edu.
Andrés J
AJ
García
D000464:Alginates / Q000008:administration & dosage / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry*; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D018914:Cells, Immobilized / Q000166:cytology* / Q000378:metabolism / Q000637:transplantation; D003094:Collagen / Q000008:administration & dosage / Q000737:chemistry; D015870:Gene Expression; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000737:chemistry; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D009135:Muscular Diseases / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D017570:MyoD Protein / Q000235:genetics / Q000378:metabolism; D051763:PAX7 Transcription Factor / Q000235:genetics / Q000378:metabolism; D012038:Regeneration / Q000502:physiology; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology* / Q000378:metabolism / Q000637:transplantation; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
D000464:Alginates; D001672:Biocompatible Materials; D006603:Hexuronic Acids; D020100:Hydrogels; D017570:MyoD Protein; C057363:MyoD1 myogenic differentiation protein; D051763:PAX7 Transcription Factor; C497321:PAX7 protein, human; D020723:Glucuronic Acid; D003094:Collagen
Aging; Biomaterial; Extracellular matrix; Niche; Satellite cells; Skeletal muscle; Stem cell therapy