Association of FCGR2A rs1801274 polymorphism with susceptibility to autoimmune diseases: A meta-analysis.
OBJECTIVE
The aim of this meta-analysis was to estimate the association between the FCGR2A rs1801274 polymorphism and the susceptibility to autoimmune diseases more precisely.


METHODS
A meta-analysis was conducted on the association between the FCGR2A gene variants and ADs by allelic contrast, homozygote contrast, the recessive model, and the dominant model.


RESULTS
A total of 17 studies with 30 comparisons in different populations and genotype-methods were available for this meta-analysis, including 10 Kawasaki disease (KD), 7 Ulcerative colitis (UC), 6 Crohn's disease (CD), 3 Rheumatoid arthritis (RA), 2 Systemic lupus erythematosus (SLE), 1 Autoimmune thyroid disease (ATD) and 1 diabetes mellitus type 1 (T1D). A significant association between FCGR2A rs1801274 polymorphism were found in KD (OR = 1.409, P < 0.001) and UC (OR = 1.237, P < 0.001). A overall meta-analysis increased risk of AD significant association between FCGR2A rs1801274 gene polymorphism and ADs under allelic (OR = 1.378, P=0.000), homozygous (OR: 1.866, P=0.001), dominant (OR = 1.667, P = 0.000) and recessive (OR = 1.434, P=0.000) in Asian population. Meanwhile, a decreased risk of AD was detected in the allelic (OR= 0.882, P = 0.011), homozygous (OR = 0.777, P = 0.013), dominant (OR = 0.850, P = 0.032) and recessive (OR = 0.840, P = 0.048) in African-American population.


CONCLUSIONS
This meta-analysis demonstrates that the FCGR2A rs1801274 G-allele confers susceptibility to KD and UC. Data also suggests that the FCGR2A rs1801274 polymorphism may be associated with the susceptibility of multiple ADs in Asian and African-American populations.
Department of Dermatology, Zhengzhou Children's Hospital, Henan, China.
Chang'e
C
Zhang
Department of Dermatology, The Second People's Hospital in Chengdu, Sichuan, China.
Wenju
W
Wang
Department of Medicine, Xiangfu District Hospital of Traditional Chinese Medicine, Kaifeng, Henan, China.
Hong'e
H
Zhang
Department of Dermatology, The First Affiliated Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
Lulu
L
Wei
Department of Dermatology, The First Affiliated Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
Shuping
S
Guo
D001741:Black or African American; D000483:Alleles; D001213:Asian; D044466:Asian People / Q000235:genetics; D001327:Autoimmune Diseases / Q000208:ethnology / Q000235:genetics*; D003093:Colitis, Ulcerative / Q000208:ethnology / Q000235:genetics*; D005787:Gene Frequency; D005799:Genes, Dominant; D005808:Genes, Recessive; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006720:Homozygote; D006801:Humans; D009080:Mucocutaneous Lymph Node Syndrome / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*; D012306:Risk
C445323:FCGR2A protein, human; D017452:Receptors, IgG
FCGR2A; Immune response; Immunity; Immunology and Microbiology Section; autoimmune diseases; meta-analysis; polymorphism; susceptibility