Development of immune organs and functioning in humans and test animals: Implications for immune intervention studies.
A healthy immune status is mostly determined during early life stages and many immune-related diseases may find their origin in utero and the first years of life. Therefore, immune health optimization may be most effective during early life. This review is an inventory of immune organ maturation events in relation to developmental timeframes in minipig, rat, mouse and human. It is concluded that time windows of immune organ development in rodents can be translated to human, but minipig reflects the human timeframes better; however the lack of prenatal maternal-fetal immune interaction in minipig may cause less responsiveness to prenatal intervention. It is too early to conclude which immune parameters are most appropriate, because there are not enough comparative immune parameters. Filling these gaps will increase the predictability of results observed in experimental animals, and guide future intervention studies by assessing relevant parameters in the right corresponding developmental time frames.
TNO, 3704 AJ, Zeist, The Netherlands.
C Frieke
CF
Kuper
TNO, 3704 AJ, Zeist, The Netherlands; Utrecht Center for Food Allergy, The Netherlands. Electronic address: j.vanbilsen@tno.nl.
Jolanda
J
van Bilsen
TNO, 3704 AJ, Zeist, The Netherlands.
Hilde
H
Cnossen
TNO, 3704 AJ, Zeist, The Netherlands; Utrecht Center for Food Allergy, The Netherlands.
Geert
G
Houben
Danone Food Safety Center, 3584 CT Utrecht, The Netherlands.
Jossie
J
Garthoff
Triskelion B.V., Zeist, The Netherlands.
Andre
A
Wolterbeek
D000375:Aging / Q000276:immunology*; D000818:Animals; D047108:Embryonic Development / Q000276:immunology*; D047109:Fetal Development / Q000276:immunology*; D006410:Hematopoiesis / Q000276:immunology*; D006801:Humans; D008221:Lymphoid Tissue / Q000196:embryology / Q000254:growth & development / Q000276:immunology; D013045:Species Specificity
Critical windows; Hematopoiesis; Immune system development; Liver; Lymph nodes; MALT; Species comparison; Spleen; Thymus