[Iodine excess induced thyroid dysfunction].
The principle sources of iodine overload, amiodarone and radiologic contrast media, are frequently used in modern medicine. The thyroid gland exerts a protective effect against iodine excess by suppressing iodine internalization into the thyrocyte and iodine organification, the Wolff-Chaikoff effect. Insufficiency of this effect or lack of escape from it leads to hypo- or hyperthyroidism respectively. Amiodarone induced thyrotoxicosis is a complex condition marked by two different pathophysiological mechanisms with different treatments. Thyroid metabolism changes after exposure to radiologic contrast media are frequent, but they rarely need to be treated. High risk individuals need to be identifed in order to delay the exam or to monitor thyroid function or apply prophylactic measures in selected cases.
Michael
M
Egloff
Jacques
J
Philippe
D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D013956:Antithyroid Agents / Q000627:therapeutic use; D003287:Contrast Media / Q000009:adverse effects*; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced; D007037:Hypothyroidism / Q000139:chemically induced; D007455:Iodine / Q000008:administration & dosage / Q000009:adverse effects* / Q000172:deficiency; D013610:Tachycardia / Q000188:drug therapy; D013971:Thyrotoxicosis / Q000139:chemically induced* / Q000188:drug therapy; D016896:Treatment Outcome
D000889:Anti-Arrhythmia Agents; D013956:Antithyroid Agents; D003287:Contrast Media; D007455:Iodine; D000638:Amiodarone