Heterogeneous nuclear ribonucleoprotein K is overexpressed and associated with poor prognosis in gastric cancer.
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is one of the major pre-mRNA-binding proteins, that is involved in translational modifications. In our previous studies, we found that hnRNP K is associated with human gastric cancer. The protein levels of hnRNP K were detected in cell lines and tissue microarrays. The correlation between hnRNP K expression and patient survival rate was evaluated by Kaplan-Meier survival analysis. In addition, we also detected hnRNP K expression in preoperative and postoperative serum samples from patients with gastric cancer, and serum samples from healthy volunteers. We found that hnRNP K was overexpressed in the gastric cancer cell lines. The levels of hnRNP K were significantly elevated in the gastric cancer tissues compared with that noted in the tumor-adjacent gastric mucosal and normal gastric mucosal sampes, and hnRNP K expression was found to correlate with tumor stage and lymph node metastasis. However, the level of serum hnRNP K did not differ significantly between gastric cancer patients and healthy volunteers. We also found that patients whose tumors showed elevated expression of hnRNP K had poor survival. The present study suggests that hnRNP K is a promising tissue biomarker for diagnosing gastric cancer and is a prognostic indicator for patients with gastric cancer.
Key Laboratory of Tumor Cellular and Molecular Pathology of the College of Hunan Province, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, P.R. China.
Ruirui
R
Yang
School of Nursing, University of South China, Hengyang, Hunan 421001, P.R. China.
Ying
Y
Zeng
The Department of Surgical Oncology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China.
Haifan
H
Xu
The Department of Surgical Oncology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China.
Zhuo
Z
Chen
Key Laboratory of Tumor Cellular and Molecular Pathology of the College of Hunan Province, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, P.R. China.
Mengqin
M
Xiang
Key Laboratory of Tumor Cellular and Molecular Pathology of the College of Hunan Province, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, P.R. China.
Yun
Y
Fu
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA.
Yufang
Y
Yin
Institute of Clinical Medicine, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China.
Jing
J
Zhong
Key Laboratory of Tumor Cellular and Molecular Pathology of the College of Hunan Province, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, P.R. China.
Min
M
Zeng
Key Laboratory of Tumor Cellular and Molecular Pathology of the College of Hunan Province, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, P.R. China.
Peihua
P
Wang
Key Laboratory of Tumor Cellular and Molecular Pathology of the College of Hunan Province, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, P.R. China.
Qin
Q
You
Key Laboratory of Tumor Cellular and Molecular Pathology of the College of Hunan Province, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, P.R. China.
Xi
X
Zeng
D014408:Biomarkers, Tumor / Q000235:genetics; D045744:Cell Line, Tumor; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D034641:Heterogeneous-Nuclear Ribonucleoprotein K / Q000235:genetics*; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012322:RNA Precursors / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*
D014408:Biomarkers, Tumor; D034641:Heterogeneous-Nuclear Ribonucleoprotein K; D012322:RNA Precursors