Infrared autofluorescence, short-wave autofluorescence and spectral-domain optical coherence tomography of optic disk melanocytomas.
OBJECTIVE
To investigate the findings of infrared fundus autofluorescence (IR-AF) and spectral-domain optical coherence tomography (SD-OCT) in eyes with optic disc melanocytoma (ODM).


METHODS
IR-AF findings and those of other ophthalmologic imaging examinations, including short-wave autofluorescence (SW-AF), fluorescein angiography (FA), fundus color photography, and SD-OCT of 8 eyes of 8 consecutive cases with ODM were assessed.


RESULTS
The ODMs in all cases (100%) presented similar IR-AF, SW-AF, and FA findings. On IR-AF images, ODMs showed outstanding hyper-AF with well-defined outline. On SW-AF images, the area of ODMs presented as hypo-AF. FA images revealed the leaking retinal telangiectasia on the surface of the ODMs. On SD-OCT images in 8 cases (100%), the ODMs were sloped with highly reflective surface, which were disorganized retina and optic nerve layers. In 7 cases (87.5%), peripapillary choroids were involved. The melanocytomas of 8 cases (100%) presented as optically empty spaces. Vitreous seeds were found in one case (12.5%).


CONCLUSIONS
IR-AF imaging may provide a new modality to evaluate the pathologic features of ODMs, and together with SW-AF imaging, offers a new tool to study biological characteristics associated with ODMs. SD-OCT is a valuable tool in delimitating the tumor extension and providing morphological information about the adjacent retinal tissue.
Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Peng
P
Zhang
Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Yan-Nian
YN
Hui
Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Wen-Qin
WQ
Xu
Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Zi-Feng
ZF
Zhang
Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Hai-Yan
HY
Wang
Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Dong-Jie
DJ
Sun
Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Yu-Sheng
YS
Wang
angiography; autofluorescence; melanocytoma; optical coherence tomography