Is there an association between systemic lupus erythematosus and periodontal disease?
Periodontal disease results from the interaction between pathogenic bacteria that colonize supragingival and subgingival biofilms and the host, triggering an inflammatory response, with systemic effects leading to immune-mediated destruction of the attachment apparatus and loss of supporting alveolar bone. Immunological pathways and predisposing genetic factors common to periodontal disease and rheumatic diseases, including systemic lupus erythematosus, have been described. Case reports have suggested greater severity of periodontal disease in patients with systemic lupus erythematosus. However, studies evaluating the influence of the treatment of one disease on the clinical and laboratory manifestations of the other have yielded conflicting results.
Post-Graduate Program in Infectious and Parasitic Diseases, Medicine School, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil. Electronic address: dccalderaro@gmail.com.
Débora Cerqueira
DC
Calderaro
Department of Locomotor System, School of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Gilda Aparecida
GA
Ferreira
Dental School, Centro Universitário Newton de Paiva, Belo Horizonte, MG, Brazil.
Santuza Maria Souza
SM
de Mendonça
Post-Graduate Program in Cell Biology, Biological Sciences Institute, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Jôice Dias
JD
Corrêa
Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Fabrícia Xavier
FX
Santos
Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
João Guilherme Capinam
JG
Sanção
Department of Clinics, Pathology and Surgery, Dental School, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Tarcília Aparecida
TA
da Silva
Medicine School, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Antônio Lúcio
AL
Teixeira
D016301:Alveolar Bone Loss; D018450:Disease Progression; D005882:Gingival Diseases; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology*; D017622:Periodontal Attachment Loss; D010510:Periodontal Diseases / Q000453:epidemiology*; D012216:Rheumatic Diseases
Chronic periodontitis; Lúpus eritematoso sistêmico; Periodontite; Periodontite crônica; Periodontitis; Systemic lupus erythematosus