Rabies vaccination at a virus-inoculated site as an alternative option to rabies immunoglobulin.
Combined active and passive immunization has been established to be an optimal strategy for rabies post-exposure prophylaxis (PEP). Prompt administration of vaccine and rabies immunoglobulin (RIG) can reliably prevent the disease. However, RIG is unavailable and unaffordable in the majority of cases. On the basis of a model experiment using hamsters, we demonstrated that vaccine injection at the wound site in the same manner as administration of RIG provided protective efficacy that was not inferior to the current optimal PEP, a combination of vaccination and RIG. Further study is needed to determine whether it can replace the use of RIG.
Faculty of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima, 731-0153, Japan. mori-k@yasuda-u.ac.jp.
Kinjiro
K
Morimoto
Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok, 10330, Thailand.
Pakamatz
P
Khawplod
Faculty of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima, 731-0153, Japan.
Yuichiro
Y
Sato
WHO Collaborating Centre for Research and Training on Viral Zoonoses, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Phatthamon
P
Virojanapirom
WHO Collaborating Centre for Research and Training on Viral Zoonoses, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Thiravat
T
Hemachudha
D000818:Animals; D006224:Cricetinae; D007136:Immunoglobulins / Q000276:immunology*; D056990:Post-Exposure Prophylaxis; D011818:Rabies / Q000401:mortality / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology
D007136:Immunoglobulins; D011819:Rabies Vaccines
Post-exposure prophylaxis (PEP); Rabies; Virus-neutralizing antibody (VNA)