Investigation of Propolis' Effect on Thiobarbituric Acid Reactive Substances and Anti-Oxidant Enzyme Levels of Hippocampus in Diabetic Rats Induced by Streptozotocin.
BACKGROUND
Propolis is an organic resinous viscous substance collected from flower bud and plant sprig by bees. Propolis has a potential treatment agent for oxidative damage caused by diabetes in hippocampus due to its flavonoid and phenolic content.


OBJECTIVE
In this study effect of propolis on thiobarbituric acid reactive substances and anti-oxidative enzyme levels of hippocampus in diabetic rats induced by streptozotocin was investigated.


METHODS
The study involved measuring levels of SOD, CAT, GSH-Px and TBARs in hippocampus tissue of STZ-induced diabetic rats (Adult Male Sprague Dawley rats) after applying propolis for one month. The subjects of the study were composed of 51 rats randomly assigned to four groups (Control, STZ, P+STZ and STZ+P). For analysis of data, Kruskal Wallis Test was utilized.


RESULTS
The findings of the study showed that there were no significant difference in the levels of TBARS, SOD, CAT and GSH-Px of hippocampus across the groups.


CONCLUSIONS
Propolis application in four-week duration does not have effect on TBARS, SOD, CAT and GSH-Px levels of hippocampus of diabetic rats. These findings mean that more time for observing oxidative harms on hippocampus is needed.
Inonu University, Faculty of Medicine, Department of Physiology, 44280 Malatya, Turkey.
Burcu
B
Köksal
Inonu University, Faculty of Medicine, Department of Physiology, 44280 Malatya, Turkey.
Memet Hanifi
MH
Emre
Inonu University, Faculty of Medicine, Department of Physiology, 44280 Malatya, Turkey.
Alaadin
A
Polat
Diabetes; anti-oxidative enzymes; propolis; rats; streptozotocine