Perspectives on Dual Targeting Delivery Systems for Brain Tumors.
Brain tumor remains one of the most serious threats to human beings. Different from peripheral tumors, drug delivery to brain tumor is largely restricted by the blood brain barrier (BBB). To fully conquer this barrier and specifically deliver drugs to brain tumor, dual targeting delivery systems were explored, which are functionalized with two active targeting ligands: one to the BBB and the other to the brain tumor. The development of dual targeting delivery system is still in its early stage, and attentions need to be paid to issues and concerns that remain unresolved in future studies.
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu, China. gaohuile@scu.edu.cn.
Huile
H
Gao
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000378:metabolism
D000970:Antineoplastic Agents
Blood brain barrier; Brain tumor; Drug delivery systems; Dual targeting