PLA micro- and nano-particles.
Poly(d,l-lactic acid) (PLA) has been widely used for various biomedical applications for its biodegradable, biocompatible, and nontoxic properties. Various methods, such as emulsion, salting out, and precipitation, have been used to make better PLA micro- and nano-particle formulations. They are widely used as controlled drug delivery systems of therapeutic molecules, including proteins, genes, vaccines, and anticancer drugs. Even though PLA-based particles have challenges to overcome, such as low drug loading capacity, low encapsulation efficiency, and terminal sterilization, continuous innovations in particulate formulations will lead to development of clinically useful formulations.
Departments of Biomedical Engineering & Pharmaceutics, Purdue University, West Lafayette, Indiana, USA.
Byung Kook
BK
Lee
Departments of Biomedical Engineering & Pharmaceutics, Purdue University, West Lafayette, Indiana, USA.
Yeonhee
Y
Yun
Departments of Biomedical Engineering & Pharmaceutics, Purdue University, West Lafayette, Indiana, USA. Electronic address: kpark@purdue.edu.
Kinam
K
Park
D000818:Animals; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*
D004337:Drug Carriers; D011091:Polyesters; C033616:poly(lactide)
Drug delivery system; Fabrication methods; Micro-particles; Nano-particles; PLA