Embedding Raman Tags between Au Nanostar@Nanoshell for Multiplex Immunosensing.
Novel Raman tags with various reporter molecules embedded in between gold nanostar (AuNS) and gold nanoshell are developed, showing significantly enhanced surface-enhanced Raman scattering intensity compared to gold nanoparticle-based composites. Immunoassay using these AuNS@tag@shell structures is highly specific with sensitivity down to 0.1 pg mL-1, and is capable of multiplex detection, making them highly promising for biosensing applications.
i-Lab and Division of Nanobiomedicine, CAS Key Laboratory of Nano-Bio Interface, CAS Center for Excellence in Nanoscience, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.
Ting
T
Yang
i-Lab and Division of Nanobiomedicine, CAS Key Laboratory of Nano-Bio Interface, CAS Center for Excellence in Nanoscience, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China. jjiang2010@sinano.ac.cn.
Jiang
J
Jiang
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D015374:Biosensing Techniques / Q000379:methods*; D006046:Gold / Q000737:chemistry*; D007118:Immunoassay; D057145:Nanoshells / Q000737:chemistry* / Q000648:ultrastructure; D013059:Spectrum Analysis, Raman
D015415:Biomarkers; D006046:Gold
Au nanostars; SERS; embedded dyes; immunosensing; multiplex