Phosphorus(V) corrole: DNA binding, photonuclease activity and cytotoxicity toward tumor cells.
A new phosphorus(V) corrole, 10-(4-hydroxylphenyl)-5,15-bis(pentafluorophenyl)corrolato (trans-dihydroxo)phosphorus(V) 1-P, was synthesized and characterized. The interaction of 1-P with calf thymus DNA (CT-DNA) was studied by multi-spectroscopic methods. The photonuclease activity of this complex was examined by agarose gel electrophoresis. 1-P may bind to CT-DNA via an outside binding mode and display good photonuclease activity. 1-P displayed low dark toxicity but high photocytotoxic activity against H460 and A549 tumor cell lines.
Department of Chemistry, South China University of Technology, Guangzhou, Guangdong 510640, China.
Yi-Guang
YG
Wang
Department of Chemistry, South China University of Technology, Guangzhou, Guangdong 510640, China.
Zhao
Z
Zhang
State Key Laboratory of Optoelectronics Materials and Technologies, Sun-Yat Sen University, Guangzhou 510275, China. Electronic address: stswh@mail.sysu.edu.cn.
Hui
H
Wang
Department of Chemistry, South China University of Technology, Guangzhou, Guangdong 510640, China. Electronic address: chhyliu@scut.edu.cn.
Hai-Yang
HY
Liu
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002417:Cattle; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D055668:Photochemical Processes; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D005464:Fluorobenzenes; D005466:Fluorocarbons
D004247:DNA; D011166:Porphyrins; C000619707:10-(4-hydroxylphenyl)-5,15-bis (pentafluorophenyl)corrole; D005464:Fluorobenzenes; D005466:Fluorocarbons
Corrole; Cytotoxicity; DNA; Phosphorus; Photonuclease activity