Versatile Route to Benzoannulated Medium-Ring Carbocycles via Aryne Insertion into Cyclic 1,3-Diketones: Application to a Synthesis of Radermachol.
A general approach involving the insertion of in situ generated aryne into the C-C bond of cyclic 1,3-diketones for rapidly assembling functionalized benzo-fused medium ring carbocycles is delineated. The efficacy of the methodology has been demonstrated through a concise total synthesis of pentacyclic natural product radermachol.
School of Chemistry, University of Hyderabad , Hyderabad 500 046, India.|Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Hyderabad 500 007, India.
Ramesh
R
Samineni
Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Hyderabad 500 007, India.
Pabbaraja
P
Srihari
School of Chemistry, University of Hyderabad , Hyderabad 500 046, India.
Goverdhan
G
Mehta