[Research progress of induced pluripotent stem cells in treatment of muscle atrophy].
Muscle atrophy caused by nerve injury is a common and difficult clinical problem. The development of stem cell researches has opened up a new way for the treatment of nerve injury-induced muscle atrophy. The induced pluripotent stem cells(iPSCs)can differentiate into various types of cells and have more advantages than embryonic stem cells (ESCs). After being transplanted into the damaged area, iPSCs are guided by neurogenic signals to the lesion sites, to repair the damaged nerve, promote generation of axon myelination, rebuild neural circuits and restore physiological function. Meanwhile, iPSCs can also differentiate into muscle cells and promote muscle tissue regeneration. Therefore, it would be possible to attenuate muscle atrophy caused by nerve injury with iPSCs treatment.
Department of Trauma Surgery, East Hospital Affiliated to Tongji University, Shanghai 200120, China.
Zhongkai
Z
Yao
Department of Trauma Surgery, East Hospital Affiliated to Tongji University, Shanghai 200120, China.
Chensong
C
Yang
Department of Trauma Surgery, East Hospital Affiliated to Tongji University, Shanghai 200120, China. sunguixin@sina.com.
Guixin
G
Sun
D000818:Animals; D004195:Disease Models, Animal; D053595:Embryonic Stem Cells; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000637:transplantation*; D009133:Muscular Atrophy / Q000628:therapy*