HCV-Induced Oxidative Stress: Battlefield-Winning Strategy.
About 150 million people worldwide are chronically infected with hepatitis C virus (HCV). The persistence of the infection is controlled by several mechanisms including the induction of oxidative stress. HCV relies on this strategy to redirect lipid metabolism machinery and escape immune response. The 3β-hydroxysterol Δ24-reductase (DHCR24) is one of the newly discovered host markers of oxidative stress. This protein, as HCV-induced oxidative stress responsive protein, may play a critical role in the pathogenesis of HCV chronic infection and associated liver diseases, when aberrantly expressed. The sustained expression of DHCR24 in response to HCV-induced oxidative stress results in suppression of nuclear p53 activity by blocking its acetylation and increasing its interaction with MDM2 in the cytoplasm leading to its degradation, which may induce hepatocarcinogenesis.
Department of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan.
Khadija
K
Rebbani
Department of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan.
Kyoko
K
Tsukiyama-Kohara
D000107:Acetylation; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000821:virology; D016174:Hepacivirus / Q000187:drug effects / Q000378:metabolism* / Q000472:pathogenicity; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy / Q000378:metabolism* / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000821:virology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000378:metabolism; D059748:Proteolysis; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D000975:Antioxidants; D000998:Antiviral Agents; D015415:Biomarkers; D009419:Nerve Tissue Proteins; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D044925:Oxidoreductases Acting on CH-CH Group Donors; C499055:DHCR24 protein, human; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2