Magnetic Multivalent Trehalose Glycopolymer Nanoparticles for the Detection of Mycobacteria.
A multivalent trehalose-grafted poly(lactic acid) is synthesized and encapsulated with iron oxide magnetic nanoparticles. The magnetic micelles interact with Mycobacterium smegmatis to form orange clusters. Very little particle interaction is found on Staphylococcus epidermidis 35984 or Escherichia coli ORN 208. The presented new approach to the detection of mycobacteria does not require molecular biology reagents or sophisticated instruments.
Department of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
Xuan
X
Chen
Department of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
Bin
B
Wu
Department of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
Kalana W
KW
Jayawardana
Department of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
Nanjing
N
Hao
David H. Koch Institute of Integrative Cancer Research Centre, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
H Surangi N
HS
Jayawardena
David H. Koch Institute of Integrative Cancer Research Centre, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Robert
R
Langer
David H. Koch Institute of Integrative Cancer Research Centre, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Ana
A
Jaklenec
Department of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
Mingdi
M
Yan
D015373:Bacterial Typing Techniques / Q000379:methods*; D004926:Escherichia coli / Q000145:classification; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D020102:Mycobacterium smegmatis / Q000145:classification*; D013212:Staphylococcus epidermidis / Q000145:classification; D014199:Trehalose / Q000737:chemistry*
D058185:Magnetite Nanoparticles; D014199:Trehalose
glycopolymer; magnetic micelles; mycobacterium; poly(lactic acid); trehalose