Relationship of Early Spontaneous Type V Blood Pressure Fluctuation after Thrombolysis in Acute Cerebral Infarction Patients and the Prognosis.
We examined the relationship between an early spontaneous type V blood pressure fluctuation and the post-thrombolysis prognosis of patients with acute cerebral infarction. Patients were admitted consecutively. All patients were categorized into the type V blood pressure fluctuation group or non-type V blood pressure group. Their blood pressure was monitored before thrombolysis and until 6 h after thrombolysis. Baseline data and clinical outcomes were compared. Of 170 patients, 43 (25.2%) had an early type V blood pressure fluctuation. The National Institute of Health Stroke Scale (NIHSS) score before thrombolysis and 24 h after thrombolysis, and the modified Rankin scale score at 90 days differed significantly between the two groups (P < 0.05). Multiple logistic regression analysis showed that an unfavorable prognosis at 3 months was associated with the NIHSS score before thrombolysis (P = 0.000) but probably not with this blood pressure fluctuation (P = 0.058). An early spontaneous type V blood pressure fluctuation is common in patients with acute cerebral infarction who received venous thrombolysis, especially if they have a higher NIHSS score before thrombolysis. The type V blood pressure fluctuation may not influence patients' prognosis; however, this needs to be confirmed in future trials.
Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Lian
L
Zuo
Department of Neurology, Shanghai East Hospital, Dalian Medical University, Liaoning Province, China.
Ting
T
Wan
Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Xiahong
X
Xu
Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Feifeng
F
Liu
Department of Neurology, Shanghai East Hospital, Dalian Medical University, Liaoning Province, China.
Changsong
C
Li
Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Ying
Y
Li
Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Yue
Y
Zhang
Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Jing
J
Zhang
Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Huan
H
Bao
Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Gang
G
Li
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D002544:Cerebral Infarction / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015912:Thrombolytic Therapy / Q000009:adverse effects*