A Polyoxometalate Cluster Paradigm with Self-Adaptive Electronic Structure for Acidity/Reducibility-Specific Photothermal Conversion.
Photothermal conversion is one of the most important keys in the fields of solar collection, photo-hyperthermia, etc., and its performance is highly dependent on the photothermal conversion materials used. Especially in cancer photo-hyperthermia, the presently available small-molecule- or nanomaterial-based agents still suffer from numerous drawbacks, such as nonspecific accumulation and inevitable side effects on normal tissues. Here we identify a Mo-based polyoxometalate cluster that can change its dimension from small (1 nm) to big (tens of nanometer), favoring its intratumoral accumulation, and enhance photothermal conversion in response to the intratumoral acidity and reducibility, demonstrating a previously unrealized tumor-specific photo-hyperthermia. Distinct from the well-researched nano-based agents, a unique electronic structure of this cluster has been identified as the origin of the observed acidity-induced self-assembly and reduction-promoted NIR absorbance. In addition to providing a promising clinical agent, this finding is expected to establish a new physicochemical paradigm for photothermal materials design based on clusters.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, P.R. China.
Chen
C
Zhang
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, P.R. China.|Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University , Shanghai 200062, P.R. China.
Wenbo
W
Bu
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, P.R. China.
Dalong
D
Ni
Department of Nuclear Medicine, Changhai Hospital , Shanghai 200433, P.R. China.
Changjing
C
Zuo
Department of Nuclear Medicine, Changhai Hospital , Shanghai 200433, P.R. China.
Chao
C
Cheng
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, P.R. China.
Qing
Q
Li
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, P.R. China.
Linlin
L
Zhang
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, P.R. China.
Zheng
Z
Wang
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, P.R. China.
Jianlin
J
Shi