Anticholinergic effect on cognition (AEC) of drugs commonly used in older people.
Use of anticholinergic drugs in older people is associated with increased risk of cognitive decline and of dementia and death.



We identified drugs widely used in older people and attempted to classify their anticholinergic effect on cognition (AEC) according to our three-point scale which scored AEC according to in vitro anticholinergic potency, capacity to cross the blood-brain barrier and statements made in standard texts.



In total, 165 drugs were examined. We identified 21 drugs with an AEC score of 3, 18 with a score of 2, 21 with a score of 1 and 62 with a score of 0. Owing to insufficient information, we were unable to classify 43 drugs.



A large number of drugs commonly used in older people are likely to be associated with cognitive impairment. Copyright © 2016 John Wiley & Sons, Ltd.
Pharmacy Department, Maudsley Hospital, London, UK.|Mental Health of Older Adults and Dementia Clinical Academic Group, South London and Maudsley NHS Foundation Trust, London, UK.|Institute of Pharmaceutical Science, King's College, London, UK.
Delia
D
Bishara
Mental Health of Older Adults and Dementia Clinical Academic Group, South London and Maudsley NHS Foundation Trust, London, UK.
Daniel
D
Harwood
Mental Health of Older Adults and Dementia Clinical Academic Group, South London and Maudsley NHS Foundation Trust, London, UK.
Justin
J
Sauer
Pharmacy Department, Maudsley Hospital, London, UK.|Institute of Pharmaceutical Science, King's College, London, UK.
David M
DM
Taylor
D001812:Blood-Brain Barrier / Q000187:drug effects; D018680:Cholinergic Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects*; D060825:Cognitive Dysfunction / Q000139:chemically induced*; D003704:Dementia / Q000188:drug therapy; D006801:Humans
D018680:Cholinergic Antagonists
anticholinergic; cognitive function; dementia