New 30-Noroleanane Triterpenoid Saponins from Holboellia coriacea Diels.
Three new 30-noroleanane triterpenoid saponins, akebonoic acid 28-O-β-d-glucopyranosyl-(1''→6')-β-d-glucopyranosyl ester (1), akebonoic acid 28-O-(6''-O-caffeoyl)-β-d-glucopyranosyl-(1''→6')-β-d-glucopyranosyl ester (Holboelliside A, 2) and 3β,20α,24-trihydroxy-29-norolean-12-en-28-oic acid 3-O-(6'-O-caffeoyl)-β-d-glucopyranoside (Holboelliside B, 3) were isolated from the stems of Holboellia coriacea Diels, together with five known compounds, eupteleasaponin VIII (4), 3α-akebonoic acid (5), quinatic acid (6), 3β-hydroxy-30-norhederagenin (7) and quinatoside A (8). The structures of these compounds were determined on the basis of spectral and chemical evidence. Compounds 1-5 were evaluated for their inhibitory activity against three human tumors HepG2, HCT116 and SGC-7901 cell lines in vitro.
Hunan Provincial Engineering &amp; Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China. dingwenb119@hunau.edu.cn.|Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, China. dingwenb119@hunau.edu.cn.
Wenbing
W
Ding
Hunan Provincial Engineering &amp; Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China. 15273361055@139.com.
Ye
Y
Li
Hunan Provincial Engineering &amp; Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China. lgh202@126.com.
Guanhua
G
Li
Hunan Provincial Engineering &amp; Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China. hhl_1234@126.com.
Hualiang
H
He
Hunan Provincial Engineering &amp; Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China. lizhw809718@aliyun.com.
Zhiwen
Z
Li
Hunan Provincial Engineering &amp; Technology Research Center for Biopesticide and Formulation Processing, Hunan Agricultural University, Changsha 410128, China. liyouzhi@hunau.edu.cn.|Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, China. liyouzhi@hunau.edu.cn.
Youzhi
Y
Li
D049109:Cell Proliferation / Q000187:drug effects; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes
Holboellia coriacea; cytotoxicity; nortriterpenoids; saponins