The evolution of sports participation guidelines and the influence of genotype-phenotype correlation in long QT syndrome.
Congenital Long QT Syndrome (LQTS) results in abnormal ventricular repolarization in patients with otherwise structurally normal hearts. Following the initial clinical descriptions of LQTS, there has been a great deal of investigation into the genetic etiology and pathophysiology of these entities, with the goal of improved screening tools and understanding of associated risks. Through this work, heart rhythm experts continue to revise their recommendations regarding sports eligibility. We review the evolution of sports participation recommendations for LQTS.
Department of Pediatric Electrophysiology, Cleveland Clinic Children's, Cleveland Clinic Foundation, Cleveland, OH.
Matthew L
ML
Furst
Department of Pediatric Electrophysiology, Cleveland Clinic Children's, Cleveland Clinic Foundation, Cleveland, OH. Electronic address: azizp@ccf.org.
Peter F
PF
Aziz
D016757:Death, Sudden, Cardiac / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008133:Long QT Syndrome / Q000151:congenital / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D010641:Phenotype; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D012307:Risk Factors; D013177:Sports
Genotype-phenotype correlation; Long QT syndrome; Sports guidelines; Sports participation