Syngeneic peripheral blood stem cell transplantation with immunosuppression for hepatitis-associated severe aplastic anemia.
Hepatitis-associated aplastic anemia occurs in up to 10% of all aplastic anemia cases. Syngeneic bone marrow transplantation is rare in patients with severe aplastic anemia and usually requires pre-transplant conditioning to provide engraftment. We report on a 29-year-old male patient with hepatitis-associated severe aplastic anemia who had a series of severe infectious conditions before transplantation, including tracheal inflammation. Life-threatening bleeding, which developed after bronchoscopy, was successfully treated with activated recombinant factor VII and platelet transfusions. Syngeneic peripheral blood stem cell transplantation using immunosuppressive treatment with antithymocyte globulin and cyclosporin A without high-dose pre-transplant conditioning was performed, followed by complete hematologic and hepatic recovery.
Hajduk Veljkova 1-3 21000 Novi Sad, Serbia, Phone: +381 21 484 3963 E-mail: asavic@uns.ac.rs.
Aleksandar
A
Savic
Bela
B
Balint
Ivana
I
Urosevic
Nebojsa
N
Rajic
Milena
M
Todorovic
Ivanka
I
Percic
Stevan
S
Popovic