The association of carotid intima-media thickness with serum Level of perfluorinated chemicals and endothelium-platelet microparticles in adolescents and young adults.
Perfluorinated chemicals (PFCs) have been widely used in a variety of products worldwide. Our previous study has documented a close association of higher serum level of perfluorooctane sulfonate (PFOS) with an increased carotid intima-media thickness (CIMT) in a cohort of adolescents and young adults. Herein, we further investigated the association of oxidative stress, circulating endothelial microparticles (EMPs) and platelet microparticles (PMPs) with PFCs and CIMT in humans. We recruited 848 subjects (12-30years old) from a population-based sample to determine the relationship between serum levels of PFCs, EMPs (CD62E and CD31+/CD42a-), PMPs (CD62P and CD31+/CD42a+), and the urine levels of 8-hydroxydeoxyguanosine (8-OHdG) and CIMT. The results showed that CD31+/CD42a- (endothelial apoptosis marker) and CD31+/CD42a+ (platelet apoptosis marker) increased significantly across quartiles of PFOS in multiple linear regression analysis. Furthermore, the elevation of CD31+/CD42a- and CD31+/CD42a+ corresponded to the increase of the odds ratios of thicker CIMT (greater than 50th percentile) with higher serum PFOS concentration (greater than 50%) (OR=2.86, 95% C.I.=1.69-4.84, P<0.001) in logistic regression models. There was no association between PFC concentration and 8-OHdG. In conclusion, we found the positive association between PFOS and CIMT that was more evident when serum levels of EMPs (CD31+/CD42a-) and PMPs (CD31+/CD42a+) were elevated. Further studies are warranted to investigate the causal inference of PFOS exposure on endothelial cell damage and atherosclerosis.
Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan.
Chien-Yu
CY
Lin
Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei 10020, Taiwan; Department of Public Health, College of Public Health, National Taiwan University, Taipei 10020, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei 10002, Taiwan.
Pau-Chung
PC
Chen
Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 10002, Taiwan.
Shyh-Chyi
SC
Lo
Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei 10002, Taiwan.
Pao-Ling
PL
Torng
Department of Health Services Administration, College of Public Health, China Medical University, Taichung 404, Taiwan.
Fung-Chang
FC
Sung
Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei 10020, Taiwan; Department of Internal Medicine and Cardiovascular Center, National Taiwan University Hospital, Taipei 10002, Taiwan. Electronic address: tachensu@ntu.edu.tw.
Ta-Chen
TC
Su
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D000328:Adult; D017209:Apoptosis; D001792:Blood Platelets; D059168:Carotid Intima-Media Thickness; D055252:Cell-Derived Microparticles; D002648:Child; D015331:Cohort Studies; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D042783:Endothelial Cells; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005466:Fluorocarbons / Q000097:blood*; D006801:Humans; D008297:Male; D055815:Young Adult
D004785:Environmental Pollutants; D005466:Fluorocarbons; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine
CD31; CD42a; Carotid intima-media thickness (CIMT); Microparticles; Perfluorinated chemicals (PFCs); Perfluorooctane sulfonate (PFOS)