Modeling of Magnetite Nanoparticles Behavior under Conditions of Microcirculation and Analysis of In Vivo Toxicity.
The behavior of magnetite nanoparticles was studied in the cell chip microcapillaries. No aggregation of magnetite nanoparticles under conditions of long-term circulation was noted. Biodistribution and toxicity of magnetite nanoparticles (14 nm) and aminated magnetite after their intragastric administration to mice were studied in vivo. According to mass spectrometry and microscopy data, accumulation of nanoparticles occurred mainly in the liver cells.
BioClinicum Research and Development Center, Moscow, Russia. d.sakharov@bioclinicum.com.|Moscow State University of Mechanical Engineering (MAMI), Moscow, Russia. d.sakharov@bioclinicum.com.
D A
DA
Sakharov
National University of Science and Technology (MISiS), Moscow, Russia.
P G
PG
Rudakovskaya
BioClinicum Research and Development Center, Moscow, Russia.
D V
DV
Maltseva
BioClinicum Research and Development Center, Moscow, Russia.
E V
EV
Trushkin
Moscow State University of Mechanical Engineering (MAMI), Moscow, Russia.
S A
SA
Tonevitskaya
D000818:Animals; D021461:Animals, Outbred Strains; D004353:Drug Evaluation, Preclinical; D004355:Drug Stability; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D008297:Male; D051379:Mice; D008833:Microcirculation; D046210:Microfluidic Analytical Techniques; D008954:Models, Biological; D012996:Solutions; D014018:Tissue Distribution
D058185:Magnetite Nanoparticles; D012996:Solutions
in vivo toxicity; magnetite nanoparticles; microcapillary; simulation