Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes.
This study investigates the anti-diabetic effects of rutin from tartary buckwheat sprout in type 2 diabetes mouse model. The rutin content in tartary buckwheat sprout (TBS) is five times higher than that found in common buckwheat sprout (CBS) as evident from high-performance liquid chromatography analysis. Administration of either rutin or TBS ethanolic extract to diabetes mice decreased the serum glucose level significantly. Rutin down-regulated the expression levels of protein-tyrosine phosphatase 1B; it is negative regulator of insulin pathway, both transcriptionally and translationally in myocyte C2C12 in a dose-dependent manner. In conclusion, rutin can play a critical role in down-regulation of serum glucose level in type 2 diabetes.
Dong-Gi
DG
Lee
Ik Soon
IS
Jang
Kyeong Eun
KE
Yang
So-Jung
SJ
Yoon
Sujeong
S
Baek
Joo Yong
JY
Lee
Tatsuro
T
Suzuki
Keun-Yook
KY
Chung
Sun-Hee
SH
Woo
Jong-Soon
JS
Choi
D041721:3T3-L1 Cells; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D019612:Fagopyrum / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D032448:Myoblasts, Skeletal / Q000187:drug effects / Q000201:enzymology; D008517:Phytotherapy; D010946:Plants, Medicinal; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000235:genetics / Q000378:metabolism; D012431:Rutin / Q000302:isolation & purification / Q000494:pharmacology*; D036226:Seedlings; D013997:Time Factors
D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D012431:Rutin; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; C516609:Ptpn1 protein, mouse