Clonal evolution of monosomy 7 in acquired severe aplastic anemia: Two cases treated with allogeneic hematopoietic stem cell transplantation.
Aplastic anemia (AA) may evolve into clonal diseases like myelodysplastic syndrome (MDS) and acute myeloblastic leuke¬mia (AML). Monosomy 7 is a poor prognostic chromosomal abnormality commonly associated with therapy related MDS and secondary AML. It has also been associated with leukomogenic transformation in AA. We present here two adult ma¬le patients with acquired severe AA. Both patients had received immunosuppressive therapy (IST) as first line treatment and had monosomy 7 positive clone at transformation to MDS with refractory anemia and excess of blast (RAEB-II) and AML, respectively. Both patients have undergone allogeneic hematopoietic stem cell (HSC) transplantation from their HLA identical donors (unrelated and sibling).
Ankara University Medical School, Department Of Hematology, Ankara, Turkey, Tel: +90 312 595 73 96 E-mail: sulemine@yahoo.com.
Şule Mine
ŞM
Bakanay
Pervin
P
Topçuoğlu
Aynur
A
Uğur Bilgin
Kanay
K
Yararbaş
Sibel
S
Berker Karaüzüm
Muhit
M
Özcan
Mutlu
M
Arat
Levent
L
Ündar
Osman
O
Ilhan