Usage of U7 snRNA in gene therapy of hemoglobin S disorder - is it feasible?
OBJECTIVE
Hemoglobin (Hb) S disorder [beta6(A3)Glu-->Val, GAG-->GTG] is an important hemoglobinopathy with the highest endemicity in Africa.


METHODS
Here, the author performs a basic bioinformatics gene ontology study to assess the effect of co-expression between nucleic acid sequence for human Hb S beta globin chain and U7.623.


RESULTS
According to this study, the analytical results show that fully recovery of hemoglobin in both function and biological process can be got.


CONCLUSIONS
Here, the author proposed that U7 snRNA might be a probable tool for treatment by gene therapy approach in Hb S disorder.
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