[CHANGES IN MAC ANTIBODY LEVELS BEFORE AND AFTER SURGERY AND AT THE TIME OF RELAPSE/RECURRENCE IN MAC LUNG DISEASE--Can MAC Antibodies Be an Indicator of Postoperative Relapse/Recurrence?].
BACKGROUND
Patients receiving surgical treatment for Mycobacterium avium complex (MAC), lung disease should be followed up with careful attention paid to relapse/recurrence, but there is some debate regarding the findings based on which relapse/recurrence should be diagnosed.


OBJECTIVE
We hypothesized that we might be able to use anti-GPL core IgA antibodies (MAC antibodies), which have been attracting attention as a factor that may support diagnosis of MAC lung disease, to diagnose postoperative relapse/recurrence. Therefore, we compared the levels of these antibodies before and at the time of relapse/recurrence, and also compared antibody titers before and after surgery.


RESULTS
MAC antibody titers were elevated by an average of about 50% at the time of relapse/recurrence compared to those before relapse/recurrence for 6 patients. In contrast, MAC antibody titers were about 30% lower after surgery compared to those before surgery for 37 patients.


CONCLUSIONS
It may be possible to use MAC antibodies as an indicator of postoperative relapse/recurrence for MAC lung disease.
Katsuo
K
Yamada
Yuuta
Y
Kawasumi
Ayuko
A
Yasuda
Yukio
Y
Seki
Takashi
T
Adachi
Osamu
O
Tarumi
Yuuta
Y
Hayashi
Taku
T
Nakagawa
Noritaka
N
Yamada
Kenji
K
Ogawa
D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006017:Glycolipids / Q000276:immunology; D006020:Glycopeptides / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015269:Mycobacterium avium Complex / Q000276:immunology*; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis* / Q000601:surgery*; D011184:Postoperative Period; D012008:Recurrence; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000601:surgery*
D000907:Antibodies, Bacterial; D015415:Biomarkers; D006017:Glycolipids; D006020:Glycopeptides; D007070:Immunoglobulin A