Effects of Microwave Ablation on Arterial and Venous Vasculature after Treatment of Hepatocellular Carcinoma.
Purpose To characterize vessel occlusion rates and their role in local tumor progression in patients with hepatocellular carcinoma (HCC) who underwent microwave tumor ablation. Materials and Methods This institutional review board approved, HIPAA-compliant retrospective review included 95 patients (75 men and 20 women) with 124 primary HCCs who were treated at a single center between January 2011 and March 2014. Complete occlusion of the portal veins, hepatic veins, and hepatic arteries within and directly abutting the ablation zone was identified with postprocedure contrast material-enhanced computed tomography. For each vessel identified in the ablation zone, its size and antenna spacing were recorded and correlated with vascular occlusion with logistic regression analysis. Local tumor progression rates were then compared between patent and occluded vessels for each vessel type with Fisher exact test. Results Occlusion was identified in 39.7% of portal veins (29 of 73), 15.0% of hepatic veins (six of 40), and 14.2% of hepatic arteries (10 of 70) encompassed within the ablation zone. Hepatic vein occlusion was significantly correlated with a smaller vessel size (P = .036) and vessel-antenna spacing (P = .006). Portal vein occlusion was only significantly correlated with a smaller vessel size (P = .001), particularly in vessels that were less than 3 mm in diameter. Local tumor progression rates were significantly correlated with patent hepatic arteries within the ablation zone (P = .02) but not with patent hepatic (P = .57) or portal (P = .14) veins. Conclusion During microwave ablation of HCC, hepatic veins and arteries were resistant to vessel occlusion compared with portal veins, and only arterial patency within an ablation zone was related to local tumor progression.©RSNA, 2016.
From the Departments of Radiology (J.C., M.C., M.H.L., A.M., J.L.H., F.T.L., C.L.B.) and Biomedical Engineering (J.C., F.T.L., C.L.B.), University of Wisconsin-Madison, 1111 Highland Ave, WIMR 1310-O, Madison, WI 53705.
Jason
J
Chiang
From the Departments of Radiology (J.C., M.C., M.H.L., A.M., J.L.H., F.T.L., C.L.B.) and Biomedical Engineering (J.C., F.T.L., C.L.B.), University of Wisconsin-Madison, 1111 Highland Ave, WIMR 1310-O, Madison, WI 53705.
Mircea
http://orcid.org/0000-0001-9404-4650
M
Cristescu
From the Departments of Radiology (J.C., M.C., M.H.L., A.M., J.L.H., F.T.L., C.L.B.) and Biomedical Engineering (J.C., F.T.L., C.L.B.), University of Wisconsin-Madison, 1111 Highland Ave, WIMR 1310-O, Madison, WI 53705.
Matthew H
MH
Lee
From the Departments of Radiology (J.C., M.C., M.H.L., A.M., J.L.H., F.T.L., C.L.B.) and Biomedical Engineering (J.C., F.T.L., C.L.B.), University of Wisconsin-Madison, 1111 Highland Ave, WIMR 1310-O, Madison, WI 53705.
Anna
A
Moreland
From the Departments of Radiology (J.C., M.C., M.H.L., A.M., J.L.H., F.T.L., C.L.B.) and Biomedical Engineering (J.C., F.T.L., C.L.B.), University of Wisconsin-Madison, 1111 Highland Ave, WIMR 1310-O, Madison, WI 53705.
J Louis
JL
Hinshaw
From the Departments of Radiology (J.C., M.C., M.H.L., A.M., J.L.H., F.T.L., C.L.B.) and Biomedical Engineering (J.C., F.T.L., C.L.B.), University of Wisconsin-Madison, 1111 Highland Ave, WIMR 1310-O, Madison, WI 53705.
Fred T
FT
Lee
From the Departments of Radiology (J.C., M.C., M.H.L., A.M., J.L.H., F.T.L., C.L.B.) and Biomedical Engineering (J.C., F.T.L., C.L.B.), University of Wisconsin-Madison, 1111 Highland Ave, WIMR 1310-O, Madison, WI 53705.
Christopher L
CL
Brace
D055011:Ablation Techniques; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D003287:Contrast Media; D018450:Disease Progression; D005260:Female; D006499:Hepatic Artery / Q000601:surgery; D006503:Hepatic Veins / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D008875:Middle Aged; D011169:Portal Vein / Q000601:surgery; D012189:Retrospective Studies; D013927:Thrombosis / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D003287:Contrast Media