Magnetic Resonance Spectroscopy in Patients with Insomnia: A Repeated Measurement Study.
Chronic insomnia is one of the most prevalent central nervous system disorders. It is characterized by increased arousal levels, however, the neurobiological causes and correlates of hyperarousal in insomnia remain to be further determined. In the current study, magnetic resonance spectroscopy was used in the morning and evening in a well-characterized sample of 20 primary insomnia patients (12 females; 8 males; 42.7 ± 13.4 years) and 20 healthy good sleepers (12 females; 8 males; 44.1 ± 10.6 years). The most important inhibitory and excitatory neurotransmitters of the central nervous system, γ-aminobutyric acid (GABA) and glutamate/glutamine (Glx), were assessed in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC). The primary hypothesis, a diurnal effect on GABA levels in patients with insomnia, could not be confirmed. Moreover, the current results did not support previous findings of altered GABA levels in individuals with insomnia. Exploratory analyses, however, suggested that GABA levels in the ACC may be positively associated with habitual sleep duration, and, thus, reduced GABA levels may be a trait marker of objective sleep disturbances. Moreover, there was a significant GROUP x MEASUREMENT TIME interaction effect on Glx in the DLPFC with increasing Glx levels across the day in the patients but not in the control group. Therefore, Glx levels may reflect hyperarousal at bedtime in those with insomnia. Future confirmatory studies should include larger sample sizes to investigate brain metabolites in different subgroups of insomnia.
Department of Clinical Psychology and Psychophysiology, Center for Mental Disorders, University Medical Center Freiburg, Freiburg, Germany.|Freiburg Institute of Advanced Studies (FRIAS), University of Freiburg, Freiburg, Germany.
Kai
K
Spiegelhalder
Department of Clinical Psychology and Psychophysiology, Center for Mental Disorders, University Medical Center Freiburg, Freiburg, Germany.
Wolfram
W
Regen
Department of Clinical Psychology and Psychophysiology, Center for Mental Disorders, University Medical Center Freiburg, Freiburg, Germany.
Christoph
C
Nissen
Department of Clinical Psychology and Psychophysiology, Center for Mental Disorders, University Medical Center Freiburg, Freiburg, Germany.
Bernd
B
Feige
Department of Clinical Psychology and Psychophysiology, Center for Mental Disorders, University Medical Center Freiburg, Freiburg, Germany.
Chiara
C
Baglioni
Department of Clinical Psychology and Psychophysiology, Center for Mental Disorders, University Medical Center Freiburg, Freiburg, Germany.
Dieter
D
Riemann
Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany.
Jürgen
J
Hennig
Freiburg Institute of Advanced Studies (FRIAS), University of Freiburg, Freiburg, Germany.|Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany.
Thomas
T
Lange
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D001923:Brain Chemistry; D016022:Case-Control Studies; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005973:Glutamine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid