Inhibitory Effects of Ellagic Acid on Glucosyltransferases from Mutans Streptococci.
Ellagic acid and its derivatives were found to abrogate the enzymatic activity of the glucosyltransferases (GTases) of mutans streptococci. These compounds preferentially inhibited the water-soluble glucan synthesis by GTase of Streptococcus mutans MT8148 and inhibited the water-insoluble glucan synthesis by GTase of Streptococcus sobrinus 6715. This inhibition resulted in a reduction of cellular adherence of mutans streptococci to a glass surface.
a Nippon Flour Mills Co., Ltd., Central Laboratory , Nurumizu, Atsugi , Kanagawa 243 , Japan.|b Department of Oral Microbiology , Osaka University Faculty of Dentistry , Yamadaoka, Suita , Osaka 565 , Japan.
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Sawamura
a Nippon Flour Mills Co., Ltd., Central Laboratory , Nurumizu, Atsugi , Kanagawa 243 , Japan.
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Tonosaki
a Nippon Flour Mills Co., Ltd., Central Laboratory , Nurumizu, Atsugi , Kanagawa 243 , Japan.|b Department of Oral Microbiology , Osaka University Faculty of Dentistry , Yamadaoka, Suita , Osaka 565 , Japan.
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Hamada