Levels of l-ascorbic acid and cadmium in the saphenous vein of patients with coronary artery disease are negatively correlated.
BACKGROUND
The aim of this study was the simultaneous determination of levels of cadmium and l-ascorbic Acid (AA) in human saphenous vein (SV) used in coronary artery bypass grafting (CABG) and check whether there is a relationship between these levels.


METHODS
Human SV were collected from 40 patients (20 men and 20 women; age, 40-75 years) at the time of routine coronary artery surgical revascularization. The concentration of cadmium in the tissue was determined according to the GF AAS-atomic absorption method. The concentration of AA was assayed in supernatant by FIA method with spectrophotometric detection.


RESULTS
AA concentration (mean±SD); men: 98,7±13,18μg/g tissue, women: 96,06±11,98μg/g tissue. Cadmium concentration(mean±SD); men: 309±103,71ng/g tissue, women: 348,5±255,71ng/g tissue. Correlations among concentrations of AA and cadmium were insignificant negative in the group of men (Pearson r=-0,1504, p=0,5269) and in the group women (Pearson r=-0339, p=0144).


CONCLUSIONS
Negative correlations among concentrations of AA and cadmium in human SV obtained in our study may indicate a protective effect of this vitamin in relation to toxic cadmium.
Department of Biophysics, Medical University of Bialystok, ul. Mickiewicza 2A, 15-222 Białystok, Poland. Electronic address: kleszczt@umb.edu.pl.
Tomasz
T
Kleszczewski
Institute of Health Care, Higher Vocational School of Suwałki, Poland.
Ewa
E
Kleszczewska
Department of Cardiac Surgery, Medical University of Bialystok, Poland and Department of Cardiac Surgery and The Regional Specialist Hospital in Olsztyn, Poland.
Leszek
L
Buzun
Department of Biophysics, Medical University of Bialystok, ul. Mickiewicza 2A, 15-222 Białystok, Poland.
Beata
B
Modzelewska
D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000032:analysis* / Q000627:therapeutic use; D002104:Cadmium / Q000032:analysis* / Q000633:toxicity; D003324:Coronary Artery Disease / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012501:Saphenous Vein / Q000737:chemistry*
D002104:Cadmium; D001205:Ascorbic Acid
Ascorbic acid; Cadmium; Level; Saphenous vein