Enzymatic synthesis of bioactive compounds with high potential for cosmeceutical application.
Cosmeceuticals are cosmetic products containing biologically active ingredients purporting to offer a pharmaceutical therapeutic benefit. The active ingredients can be extracted and purified from natural sources (botanicals, herbal extracts, or animals) but can also be obtained biotechnologically by fermentation and cell cultures or by enzymatic synthesis and modification of natural compounds. A cosmeceutical ingredient should possess an attractive property such as anti-oxidant, anti-inflammatory, skin whitening, anti-aging, anti-wrinkling, or photoprotective activity, among others. During the past years, there has been an increased interest on the enzymatic synthesis of bioactive esters and glycosides based on (trans)esterification, (trans)glycosylation, or oxidation reactions. Natural bioactive compounds with exceptional theurapeutic properties and low toxicity may offer a new insight into the design and development of potent and beneficial cosmetics. This review gives an overview of the enzymatic modifications which are performed currently for the synthesis of products with attractive properties for the cosmeceutical industry.
Division of Chemical Engineering, Department of Civil, Environmental and Natural Resources Engineering, Luleå University of Technology, 97187, Luleå, Sweden.
Io
I
Antonopoulou
Department of Chemical Sciences, University of Naples "Federico II", Naples, Italy.
Simona
S
Varriale
Biotechnology Laboratory, School of Chemical Engineering, National Technical University of Athens, 15700, Athens, Greece.
Evangelos
E
Topakas
Division of Chemical Engineering, Department of Civil, Environmental and Natural Resources Engineering, Luleå University of Technology, 97187, Luleå, Sweden.
Ulrika
U
Rova
Division of Chemical Engineering, Department of Civil, Environmental and Natural Resources Engineering, Luleå University of Technology, 97187, Luleå, Sweden.
Paul
P
Christakopoulos
Department of Chemical Sciences, University of Naples "Federico II", Naples, Italy. vfaraco@unina.it.
Vincenza
V
Faraco
D001419:Bacteria / Q000378:metabolism*; D000068937:Cosmeceuticals / Q000138:chemical synthesis* / Q000494:pharmacology*; D003358:Cosmetics / Q000138:chemical synthesis / Q000494:pharmacology; D004952:Esters / Q000138:chemical synthesis / Q000494:pharmacology; D005658:Fungi / Q000378:metabolism*; D006027:Glycosides / Q000138:chemical synthesis / Q000494:pharmacology; D012867:Skin / Q000187:drug effects*
D000068937:Cosmeceuticals; D003358:Cosmetics; D004952:Esters; D006027:Glycosides
Anti-aging; Anti-inflammatory; Anti-microbial; Anti-oxidant; Anti-wrinkling; Bacterial; Feruloyl esterases; Fungal; Glycosidases; Laccases; Lipases; Photoprotective; Proteases; Skin whitening; Tannases; Transferases