A TOGgle for Tension at Kinetochores.
Differential stability of kinetochore-microtubule attachments at low versus high tension is critical for accurate chromosome segregation. Miller et al. find that a TOG domain microtubule-binding protein imparts intrinsic tension selectivity to kinetochore-microtubule attachments.
Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, CA 92093, USA; Ludwig Institute for Cancer Research, San Diego, CA 92093, USA.
Dhanya K
DK
Cheerambathur
Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, CA 92093, USA; Ludwig Institute for Cancer Research, San Diego, CA 92093, USA.
Bram
B
Prevo
Department of Cellular & Molecular Medicine, University of California San Diego, San Diego, CA 92093, USA; Ludwig Institute for Cancer Research, San Diego, CA 92093, USA. Electronic address: abdesai@ucsd.edu.
Arshad
A
Desai
D020090:Chromosome Segregation; D018386:Kinetochores; D008870:Microtubules / Q000235:genetics; D008941:Spindle Apparatus / Q000378:metabolism