2-Trifluoromethylthiolation of glycals.
Methods for trifluoromethylthiolation are very limited. To tackle this problem, a mild and efficient approach to the 2-trifluoromethylthiolation of glycals has been developed. This protocol employed N-trifluoromethylthiosaccharin as the trifluoromethylthiolating reagent, TMSCl as the activator, and DBU as the base, affording 2-trifluoromethylthioglycals in good yields. These trifluoromethylthiolated carbohydrates may benefit the development of carbohydrate-based drugs.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing 100191, China. xinshan@bjmu.edu.cn.
Yang
Y
Yu
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing 100191, China. xinshan@bjmu.edu.cn.
De-Cai
DC
Xiong
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing 100191, China. xinshan@bjmu.edu.cn.
Xin-Shan
XS
Ye
D002241:Carbohydrates / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D002241:Carbohydrates; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D013438:Sulfhydryl Compounds