Serum RDW and MPV in Ankylosing Spondylitis: Can they show the disease activity?
OBJECTIVE
To determine RDW and MPV levels in Ankylosing Spondylitis (AS) and to investigate their relations with disease activity.


METHODS
133 patients with AS (male: 80, female: 53) and age-sex matched 133 controls (male: 79, female: 54) were enrolled. Demographic data, disease activity scores, Complete Blood Count (CBC), Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) levels were recorded.


RESULTS
The mean ages of patients and controls were 41.9±11.2 and 39.7±14.2 years respectively (p = 0.16). RDW (14.5±1.6% and 13.2±0.8%, p < 0.0001 respectively) and MPV (10.1±0.8fl and 9.9±0.7fl, p = 0.03, respectively) were significantly higher in patients with AS than in controls. There was a significant difference in RDW between patients with active AS (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) >4) and those with inactive AS (BASDI <4) patients (14.84±1.79fl, 14.24±1.37fl, p = 0.035 respectively). RDW was positively correlated with BASDAI (r = 0.33, P < 0.0001), ESR (r = 0.45, P < 0.0001) and CRP (r = 0.42, P < 0.0001) and PLT levels (r = 0.24, P = 0.004). While MPV was not correlated with BASDAI, it was negatively correlated with ESR (r = -0.19, P = 0.03), CPR (r = -0.26, P = 0.004) and PLT levels (r = -0.39, P = <0.0001).


CONCLUSIONS
RDW and MPV were significantly higher in the patients with AS than in the controls. While RDW was correlated with BASDAI and APRs, MPV was only correlated with APRs.
Mersin University Medical Faculty, Department of Physical Medicine and Rehabilitation, Mersin, Turkey.
Melek
M
Sezgin
Gazi University Medical Faculty, Department of Physical Medicine and Rehabilitation, Ankara, Turkey.
Duygu
D
Tecer
Mersin University Medical Faculty, Department of Biostatistics and Medical Informatics, Mersin, Turkey.
Arzu
A
Kanık
Mersin University Medical Faculty, Department of Physical Medicine and Rehabilitation, Mersin, Turkey.
Fulya Sultan
FS
Kekik
Mersin University Medical Faculty, Department of Physical Medicine and Rehabilitation, Mersin, Turkey.
Evren
E
Yeşildal
Mersin University Medical Faculty, Department of Physical Medicine and Rehabilitation, Mersin, Turkey.
Erbil
E
Akaslan
Mersin University Medical Faculty, Department of Physical Medicine and Rehabilitation, Mersin, Turkey.
Gonca
G
Yıldırım
Mersin University Medical Faculty, Department of Physical Medicine and Rehabilitation, Mersin, Turkey.
Günşah
G
Şahin
D000328:Adult; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D013167:Spondylitis, Ankylosing / Q000175:diagnosis*
D002097:C-Reactive Protein
Ankylosing Spondylitis; BASDAI; Mean Platelet Volume; Red Cell Distrubution Width