[Parkinson's disease and nucleolar stress].
Parkinson's disease (PD) is a common age-related neurodegenerative disorder characterized mainly by motor dysfunction resulting in bradykinesia, rigidity, tremor, gait impairment, and postural instability. The classic pathogenic feature of PD is preferential loss of dopaminergic neurons in the substantia nigra. Downregulation of rRNA transcription is one of major mechanisms to maintain cellular homeostasis under stress conditions. Nucleolar stress has emerged as a component of the degenerative process caused by impaired rRNA transcription and altered nucleolar integrity. Recent study has indicated that the response to stress conditions and quality control mechanisms are impaired in PD, and that metabolic stress may be a trigger mechanism for PD. This review aims to present evidence for a role of nucleolar stress in PD and has summarized mechanisms by which nucleolar stress may play a role in the progression of PD.
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. hfshang2002@126.com.
Qingqing
Q
Zhou
Yongping
Y
Chen
Qianqian
Q
Wei
Huifang
H
Shang
D002466:Cell Nucleolus / Q000502:physiology*; D006801:Humans; D010300:Parkinson Disease / Q000209:etiology / Q000503:physiopathology*; D012335:RNA, Ribosomal / Q000235:genetics; D015398:Signal Transduction; D013312:Stress, Physiological; D058570:TOR Serine-Threonine Kinases / Q000502:physiology
D012335:RNA, Ribosomal; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases