The Extracellular Matrix of Fungal Biofilms.
A key feature of biofilms is their production of an extracellular matrix. This material covers the biofilm cells, providing a protective barrier to the surrounding environment. During an infection setting, this can include such offenses as host cells and products of the immune system as well as drugs used for treatment. Studies over the past two decades have revealed the matrix from different biofilm species to be as diverse as the microbes themselves. This chapter will review the composition and roles of matrix from fungal biofilms, with primary focus on Candida species, Saccharomyces cerevisiae, Aspergillus fumigatus, and Cryptococcus neoformans. Additional coverage will be provided on the antifungal resistance proffered by the Candida albicans matrix, which has been studied in the most depth. A brief section on the matrix produced by bacterial biofilms will be provided for comparison. Current tools for studying the matrix will also be discussed, as well as suggestions for areas of future study in this field.
Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Kaitlin F
KF
Mitchell
Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Robert
R
Zarnowski
Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA. dra@medicine.wisc.edu.
David R
DR
Andes
D000818:Animals; D018441:Biofilms; D005109:Extracellular Matrix / Q000737:chemistry* / Q000378:metabolism; D005658:Fungi / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009181:Mycoses / Q000382:microbiology*
Antifungal resistance; Biofilm; Candida albicans; Device-associated infections; Extracellular matrix