Selenium status in neonates with connatal infection.
Infectious diseases impair Se metabolism, and low Se status is associated with mortality risk in adults with critical disease. The Se status of neonates is poorly characterised, and a potential impact of connatal infection is unknown. We hypothesised that an infection negatively affects the Se status of neonates. We conducted an observational case-control study at three intensive care units at the Charité-Universitätsmedizin Berlin, Germany. Plasma samples were collected from forty-four neonates. On the basis of clinical signs for bacterial infection and concentrations of IL-6 or C-reactive protein, neonates were classified into control (n 23) and infected (n 21) groups. Plasma Se and selenoprotein P (SePP) concentrations were determined by X-ray fluorescence and ELISA, respectively, at day of birth (day 1) and 48 h later (day 3). Se and SePP showed a positive correlation in both groups of neonates. Se concentrations indicative of Se deficit in adults (500 ng/l). During antibiotic therapy, SePP increased significantly from day 1 (1·03 (sd 0·10) mg/l) to day 3 (1·34 (sd 0·10) mg/l), indicative of improved hepatic Se metabolism. We conclude that both Se and SePP are suitable biomarkers for assessing Se status in neonates and for identifying subjects at risk of deficiency.
1Institute for Experimental Endocrinology,Charité Universitätsmedizin Berlin,Suedring 10,Campus Virchow-Klinikum,D-13353 Berlin,Germany.
Lennart
L
Wiehe
2Department of Neonatology,Charité Universitätsmedizin Berlin,Mittelallee 9,Campus Virchow-Klinikum,D-13353 Berlin,Germany.
Malte
M
Cremer
1Institute for Experimental Endocrinology,Charité Universitätsmedizin Berlin,Suedring 10,Campus Virchow-Klinikum,D-13353 Berlin,Germany.
Monika
M
Wisniewska
1Institute for Experimental Endocrinology,Charité Universitätsmedizin Berlin,Suedring 10,Campus Virchow-Klinikum,D-13353 Berlin,Germany.
Niels-Peter
NP
Becker
1Institute for Experimental Endocrinology,Charité Universitätsmedizin Berlin,Suedring 10,Campus Virchow-Klinikum,D-13353 Berlin,Germany.
Eddy
E
Rijntjes
1Institute for Experimental Endocrinology,Charité Universitätsmedizin Berlin,Suedring 10,Campus Virchow-Klinikum,D-13353 Berlin,Germany.
Janine
J
Martitz
1Institute for Experimental Endocrinology,Charité Universitätsmedizin Berlin,Suedring 10,Campus Virchow-Klinikum,D-13353 Berlin,Germany.
Sandra
S
Hybsier
1Institute for Experimental Endocrinology,Charité Universitätsmedizin Berlin,Suedring 10,Campus Virchow-Klinikum,D-13353 Berlin,Germany.
Kostja
K
Renko
2Department of Neonatology,Charité Universitätsmedizin Berlin,Mittelallee 9,Campus Virchow-Klinikum,D-13353 Berlin,Germany.
Christoph
C
Bührer
1Institute for Experimental Endocrinology,Charité Universitätsmedizin Berlin,Suedring 10,Campus Virchow-Klinikum,D-13353 Berlin,Germany.
Lutz
L
Schomburg
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003677:Deficiency Diseases / Q000097:blood / Q000209:etiology*; D005260:Female; D005858:Germany; D006801:Humans; D007231:Infant, Newborn; D007239:Infections / Q000097:blood* / Q000188:drug therapy; D015850:Interleukin-6 / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D009752:Nutritional Status; D012643:Selenium / Q000097:blood / Q000172:deficiency*; D051149:Selenoprotein P / Q000097:blood*
D000900:Anti-Bacterial Agents; D015415:Biomarkers; D015850:Interleukin-6; D051149:Selenoprotein P; D002097:C-Reactive Protein; D012643:Selenium
CRP C-reactive protein; Gentamicin; IL-6; IQR interquartile range; Intensive care; Micronutrients; SePP selenoprotein P; Selenoproteins