Characteristics of human papillomaviruses infection in men with genital warts in Shanghai.
Human papillomaviruses (HPV) infected men causes continued transmission of HPV to women. The prevalence of 15 high-risk HPV strains (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66 and 68) and 6 low-risk HPV strains (HPV6, 11, 42, 43, 44 and CP8304) were evaluated in 935 males with genital warts. Of the 447 (447/935, 47.8%) HPV DNA positive subjects, 230 (24.6%), 356 (38.1%) and 139 (14.9%) were infected by high-risk, low-risk and both high and low-risk HPV respectively. Of the 356 low-risk HPV infected subjects, 333(93.5%) were infected by single HPV strain; 203 (57.0%), 147 (41.3%), 24 (6.7%) and 5 (1.4%) were infected with HPV genotype 6, 11, CP8304 and 44 respectively; population with age ≤ 20 showed the highest infection rate. High-risk HPV are also highly prevalent in our patients, genotype 16, 58, 51, 39, 52 and 53 are the top five prevalent genotypes with infection rates of 27.4%, 18.7%, 14.3%, 13.9%, 12.6% and 12.6% respectively; only 68.3% subjects were sole infection; subjects with 41 ≤ age ≤ 50 showed the highest infection rate. Both high and low-risk HPV are highly prevalent in men with genital warts, its impact on women HPV control and prevention need further evaluation.
Department of Dermatologic Surgery, Shanghai Dermatology Hospital, Shanghai, 200442, China.
Xiaogang
X
Chen
Department of Dermatologic Surgery, Shanghai Dermatology Hospital, Shanghai, 200442, China.
Liang
L
Li
Department of Dermatologic Surgery, Shanghai Dermatology Hospital, Shanghai, 200442, China.
Yongxian
Y
Lai
Department of Dermatologic Surgery, Shanghai Dermatology Hospital, Shanghai, 200442, China.
Qinxiu
Q
Liu
Department of Dermatologic Surgery, Shanghai Dermatology Hospital, Shanghai, 200442, China.
Jianna
J
Yan
Department of Dermatologic Surgery, Shanghai Dermatology Hospital, Shanghai, 200442, China.
Yichen
Y
Tang
D000328:Adult; D017677:Age Distribution; D002681:China; D003218:Condylomata Acuminata / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D015995:Prevalence; D055815:Young Adult
genital warts; high-risk HPV; human papillomaviruses; low-risk HPV; male