Recent advancements in nanotechnological strategies in selection, design and delivery of biomolecules for skin regeneration.
Skin is a very complex organ and hence designing a bioengineered skin model replicating the essential physiological characteristics for replacing the diseased or damaged parts has been a challenging goal for many. Newer technologies for satisfying most of the criteria are being attempted with the copious efforts of biologists, engineers, physiologists, using multitude of features in combination. Amongst them nanotechnology based biomaterials have gained prominence owing to the enhanced pharmacokinetics, bio-distribution profile, extended half-life and reduced side effects. Designing a matrix that can be assimilated into the body during the regeneration and delivering the essential pharmacological agents in a temporal and spatially specific manner is a tremendous goal. This review essentially deals with the various approaches for designing a multidisciplinary translational smart matrix for addressing the various skin related ailments.
Biomaterials Department, CSIR-Central Leather Research Institute, Adyar, Chennai 600 020, India.
Purna Sai
PS
Korrapati
Biomaterials Department, CSIR-Central Leather Research Institute, Adyar, Chennai 600 020, India.
K
K
Karthikeyan
Biomaterials Department, CSIR-Central Leather Research Institute, Adyar, Chennai 600 020, India.
Aishwarya
A
Satish
Biomaterials Department, CSIR-Central Leather Research Institute, Adyar, Chennai 600 020, India.
Venkat Raghavan
VR
Krishnaswamy
Center for Nanofibers & Nanotechnology, Department of Mechanical Engineering, National University of Singapore, 117584, Singapore.
Jayarama Reddy
JR
Venugopal
Center for Nanofibers & Nanotechnology, Department of Mechanical Engineering, National University of Singapore, 117584, Singapore.
Seeram
S
Ramakrishna
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D006801:Humans; D036103:Nanotechnology / Q000379:methods* / Q000639:trends; D012038:Regeneration / Q000187:drug effects*; D044968:Regenerative Medicine / Q000379:methods* / Q000639:trends; D012867:Skin; D012879:Skin Physiological Phenomena / Q000187:drug effects*
Biopolymer; Drug delivery; Nanofibers; Nanoparticles; Regeneration; Skin; Stem cells; Tissue engineering