[Contraction (retraction) of blood clots in patients with ischemic stroke].
OBJECTIVE
To study a possible pathogenetic role of the blood clot contraction and its disturbances in the acute stage of ischemic stroke (IS).


METHODS
Using a new instrumental technique to study the dynamics of clot contraction in vitro, the authors have determined quantitative parameters of clot contraction (the extent and rate of contraction, duration of the lag-period) in the blood of 85 patients with acute IS.


CONCLUSIONS
The contractile activity of blood clots was substantially reduced compared to the blood of healthy subjects. Correlations between hemostatic and contractile parameters suggest that the reduced clot contraction in stroke is due to the lower platelet count and impaired platelet functionality, higher levels of fibrinogen and antithrombin III as well as higher hematocrit and hemoglobin contents, leukocytosis, and changes in the biochemical blood composition. The results show that the reduced ability of clots may be a novel pathogenic mechanism that aggravates the course and outcomes of IS.
Kazan Federal University, Kazan.
A D
AD
Peshkova
Inter-Region Clinical Diagnostic Center, Kazan.
M V
MV
Saikhunov
Inter-Region Clinical Diagnostic Center, Kazan.
T V
TV
Demin
Kazan Federal University, Kazan.
A P
AP
Lozhkin
Inter-Region Clinical Diagnostic Center, Kazan.
M V
MV
Panasyuk
Kazan Federal University, Kazan.
R I
RI
Litvinov
Inter-Region Clinical Diagnostic Center, Kazan; Kazan State Medical University, Kazan.
D R
DR
Khasanova
D001792:Blood Platelets / Q000502:physiology; D002545:Brain Ischemia / Q000503:physiopathology*; D005340:Fibrinogen; D006487:Hemostasis; D006801:Humans; D020521:Stroke / Q000503:physiopathology*; D013927:Thrombosis
D005340:Fibrinogen