Lysosomotropic REV-ERB antagonism: A metabolic connection between circadian rhythm and autophagy may tell cancer cells "it's time to die".
The discovery that inhibition of a circadian regulator enhances autophagy-dependent cancer cell death reveals potential avenues for the development of new multifunctional anticancer agents. Further studies may elucidate novel crosstalk between circadian rhythm, metabolism, and autophagy that determines cancer cell viability.
Istituto Italiano di Tecnologia; Department of Drug Discovery and Development ; Genova, Italy.
Benedetto
B
Grimaldi
REV-ERB; anticancer agents; autophagy; cancer metabolism; chronotherapy; circadian clock; dual inhibitor; nuclear receptors