Analyzing the association between XRCC1 c.1804C>A genetic variant and lung cancer susceptibility in the Chinese population.
Lung cancer is the most common cancer occurring worldwide. The human X-ray repair complementing group 1 (XRCC1) gene is one of the most important candidate genes that influence the susceptibility to lung cancer. The objective of this study was to analyze the potential association between the c.1804C>A genetic variant of XRCC1 and lung cancer susceptibility. A total of 703 subjects were recruited for this study. Genotyping of c.1804C>A genetic variant was performed using the created restriction site-polymerase chain reaction. Statistically significant differences in allele frequencies and genotype were found between lung cancer patients and cancer-free controls. The genotype AA was statistically associated with the increased risk of lung cancer when compared to the wild genotype, CC, and the carrier genotype, CA/CC (AA vs CC: OR = 2.71, 95%CI = 1.57-4.67, P < 0.001; AA vs
OR = 2.54, 95%CI = 1.50-4.29, P < 0.001). The allele A likely contributes to the susceptibility to lung cancer (A vs C: OR = 1.47, 95%CI = 1.17-1.84, P = 0.001). Our data indicates that the c.1804C>A genetic variant of XRCC1 is statistically associated with the susceptibility to lung cancer in the Chinese population.
Department of Respiratory and Critical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou.
J J
JJ
Jin
Department of Respiratory and Critical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou.
H Q
HQ
Wang
Department of Respiratory and Critical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou.
H P
HP
Kuang
Department of Respiratory and Critical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou.
B B
BB
Kang
Department of Respiratory and Critical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou.
Y H
YH
Liu
Department of Respiratory and Critical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou.
J
J
Wang
D000368:Aged; D044466:Asian People / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D000076105:X-ray Repair Cross Complementing Protein 1
D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human