Evolutionary features of thyroid cancer in patients with thyroidectomies from 2008 to 2013 in China.
To evaluate the characteristics of thyroid carcinoma over time, we carried out a retrospective study to illustrate the evolutionary features of thyroid carcinoma. All records of thyroidectomies from the First Affiliated Hospital of Nanjing Medical University from 2008 to 2013 were obtained focusing on pathological diagnosis, size, local lymph node metastasis (LNM) of the tumors. The thyroid cancer detection rate increased from 24.6% to 41.5% significantly (P < 0.05). Papillary thyroid carcinoma (PTC) remained to be the most common type counting 86.4% of all thyroid carcinomas. In all 1,704 PTCs, microPTC (mPTC) with maximum diameter less than or equal to 10 mm has become the dominant form taking up 56.5% of all PTCs in 2013 while only 43.1% in 2008. The mean maximum tumor size has decreased from 17.8 mm to 12.2 mm significantly (P < 0.05). However, the average age, female dominance, and local LNM remained similarly in the past six years. Logistic regression test showed that the determinants for local LNM were age, gender and tumor size. mPTC has become the most common form of thyroid carcinoma detected during thyroidectomies in China while other features of thyroid carcinoma remained similarly in the recent years.
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xiaoyun
X
Liu
Department of Children's Health care, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, China.
Lijun
L
Zhu
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhixiao
Z
Wang
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Dai
D
Cui
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Huanhuan
H
Chen
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yu
Y
Duan
Department of Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Meiping
M
Shen
Department of Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Hui
H
Lu
Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhihong
Z
Zhang
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jiawei
J
Chen
Thyroid Unit, Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, Brigham &Women's Hospital and Harvard Medical School, Boston, USA.
Erik K
EK
Alexander
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Tao
T
Yang
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xiaodong
X
Wang
D000328:Adult; D002681:China; D005260:Female; D006801:Humans; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000145:classification* / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods*; D047368:Tumor Burden