Nore1a drives Ras to flick the P53 senescence switch.
RAS-induced senescence is a protective mechanism to avoid unrestricted cell growth due to aberrant mitogenic signals; however, the exact mechanism by which RAS induces senescence is not known. We recently identified a novel pathway linking RAS to p53 via NORE1A and HIPK2 that mechanistically explains how Ras induces senescence.
Department of Medicine, J.G Brown Cancer Center, Molecular Targets Group, University of Louisville , Louisville, KY, USA.
Howard
H
Donninger
Department of Pharmacology and Toxicology, J.G Brown Cancer Center, Molecular Targets Group, University of Louisville , Louisville, KY, USA.
Geoffrey J
GJ
Clark
HIPK2; NORE1A; Ras; p53; senescence