Adolescent development of insula-dependent interoceptive regulation.
Adolescence is hypothesized to be a critical period for the maturation of self-regulatory capacities, including those that depend on interoceptive sensitivity, but the neural basis of interoceptive regulation in adolescence is unknown. We used functional magnetic resonance imaging and psychophysiology to study interoceptive regulation in healthy adolescent females. Participants regulated their gut activities in response to a virtual roller coaster by deep breathing aided by visually monitoring their online electrogastrogram (EGG) activity through a virtual thermometer (i.e. gut biofeedback), or without biofeedback. Analyses focused on the insula, given its putative role in interoception. The bilateral posterior insula showed increased activation in the no-biofeedback compared to biofeedback condition, suggesting that the participants relied more on interoceptive input when exteroceptive feedback was unavailable. The bilateral dorsal anterior insula showed activation linearly associated with age during both induction and regulation, and its activation during regulation correlated positively with change of EGG in the tachygastria frequency band from induction to regulation. Induction-related activation in the bilateral ventral anterior insula was nonlinearly associated with age and peaked at mid-adolescence. These results implicate different developmental trajectories of distinct sub-regions of the insula in interoceptive processes, with implications for competing neurobiological theories of female adolescent development.
Center for Cognitive Neuroscience, Duke University, USA.
Dawei
D
Li
Department of Psychiatry and Behavioral Sciences, Duke University, USA.
Nancy L
NL
Zucker
Center for Cognitive Neuroscience, Duke University, USA.
Philip A
PA
Kragel
Department of Psychiatry and Behavioral Sciences, Duke University, USA.
Virginia E
VE
Covington
Center for Cognitive Neuroscience, Duke University, USA.|Department of Psychiatry and Behavioral Sciences, Duke University, USA.
Kevin S
KS
LaBar
D000293:Adolescent; D041923:Adolescent Development / Q000502:physiology*; D000704:Analysis of Variance; D001676:Biofeedback, Psychology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D065812:Interoception / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D011601:Psychophysics; D055815:Young Adult
D010100:Oxygen