The importance of integrated genomics to uncover clinically relevant cancer driver genes.
Tumor heterogeneity hinders the discovery of true cancer driver genes. The recently identified role for YY1-associated protein 1 (YY1AP1) as a critical oncoprotein that is activated in a particular subtype of hepatocellular carcinoma (HCC) was elucidated through integrative genomic profiling followed by functional studies. This strategy proved effective for finding a functional cancer driver with prognostic impact.
Laboratory of Human Carcinogenesis; Center for Cancer Research; National Cancer Institute ; Bethesda, MD, USA.
Xuelian
X
Zhao
Laboratory of Human Carcinogenesis; Center for Cancer Research; National Cancer Institute ; Bethesda, MD, USA.
Sonya
S
Parpart-Li
Laboratory of Human Carcinogenesis; Center for Cancer Research; National Cancer Institute ; Bethesda, MD, USA.
Xin Wei
XW
Wang