The Vulnerability of Vessels Involved in the Role of Embolism and Hypoperfusion in the Mechanisms of Ischemic Cerebrovascular Diseases.
Accurate definition and better understanding of the mechanisms of stroke are crucial as this will guide the effective care and therapy. In this paper, we review the previous basic and clinical researches on the causes or mechanisms of ischemic cerebrovascular diseases (ICVD) and interpret the correlation between embolism and hypoperfusion based on vascular stenosis and arterial intimal lesions. It was suggested that if there is no embolus (dynamic or in situ emboli), there might be no cerebral infarction. Three kinds of different clinical outcomes of TIA were theoretically interpreted based on its mechanisms. We suppose that there is a correlation between embolism and hypoperfusion, and which mechanisms (hypoperfusion or hypoperfusion induced microemboli) playing the dominant role in each type of ICVD depends on the unique background of arterial intimal lesions (the vulnerability of vessels). That is to say, the vulnerability of vessels is involved in the role of embolism and hypoperfusion in the mechanisms of ischemic cerebrovascular diseases. This inference might enrich and provide better understandings for the underlying etiologies of ischemic cerebrovascular events.
Department of Neurology and Central Laboratory of Brain Diseases, Weihai Central Hospital, School of Medicine, Qingdao University, Shandong 264400, China.
Yong Peng
0000-0001-8298-3810
YP
Yu
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, China.
Lan
0000-0002-8759-7588
L
Tan
D002544:Cerebral Infarction / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000473:pathology*; D006801:Humans; D020766:Intracranial Embolism / Q000473:pathology*; D010477:Perfusion / Q000379:methods; D020521:Stroke / Q000473:pathology; D017539:Tunica Intima / Q000473:pathology*