The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy.
BACKGROUND
The ability to evaluate the prognosis of hepatocellular carcinoma (HCC) following hepatectomy using biological markers is of great importance.


METHODS
In this study, we collected samples from 54 patients with HCC after hepatectomy. Immunohistochemistry was used to detect the expression of Sema3C and MFN2 in the HCC samples.


RESULTS
Immunohistochemistry results showed that Sema3C and MFN2 co-expression was significantly associated with tumor size. In addition, a significant association between high Sema3C and low MFN2 levels and shorter overall survival was noted, when Sema3C and MFN2 co-expression was analyzed.


CONCLUSIONS
The results suggest that the correlative expression level of Sema3C and MFN2 has a strong value in the prognosis of patients with HCC following hepatectomy.
Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China.
Xu
X
Feng
Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China; Department of General Surgery, Yinzhou People's Hospital, Ningbo, People's Republic of China.
Kelei
K
Zhu
Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China.
Jinghua
J
Liu
Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China.
Jiang
J
Chen
Key Lab of Surgery of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Jiacheng
J
Tang
Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China.
Yuelong
Y
Liang
Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China.
Renan
R
Jin
Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China.
Xiao
X
Liang
Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China; Key Lab of Surgery of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Xiujun
X
Cai
MFN2; Sema3C; hepatocellular carcinoma (HCC); prognosis; survival analysis