Toxicity of nanoparticle surface coating agents: Structure-cytotoxicity relationship.
Surface coating agents for metal nanoparticles, cationic alkyl ammonium bromides, and anionic alkyl sulfates were tested against human skin keratinocytes (HaCaT) and blood T lymphocytes (TIB-152). The surfactants of short chain (C8) are not cytotoxic, but as chain length increases, their cytotoxicity increases and levels off at C12 for cationic surfactants against both cell lines and for anionic surfactants against the TIB-152, but C14 for anionic surfactants against HaCaT. The cationic surfactants are more toxic than the anionic surfactants for HaCaT; while with similar cytotoxicity for TIB-152 cells. di- and tetra-Alkyl ammonium salts are more cytotoxic than the mono-substituted.
a Department of Chemistry and Biochemistry , Jackson State University , Jackson , Mississippi , USA.
Ying
Y
Zhang
b Center for Nano-Environmental Science and Health, Shaanxi Normal University , Xi'an , China.
Xiaoping
X
Li
a Department of Chemistry and Biochemistry , Jackson State University , Jackson , Mississippi , USA.|b Center for Nano-Environmental Science and Health, Shaanxi Normal University , Xi'an , China.
Hongtao
H
Yu
D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D015603:Keratinocytes; D053758:Nanoparticles / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000633:toxicity*
D013501:Surface-Active Agents
Cytotoxicity; chain length; nanoparticle; surface coating agents