RARRES3 regulates signal transduction through post-translational protein modifications.
We recently reported that retinoic acid receptor responder 3 (RARRES3)-mediated protein deacylation resulted in significant inhibition of the transformed properties of breast cancer cells. This finding suggests a key role of RARRES3 in the regulation of growth signaling and metastasis in cancer cells and as a potential therapeutic target for cancer therapy.
Genomics Research Center; Academia Sinica ; Taipei, Taiwan, ROC.
Tzu-Hui
TH
Hsu
Department of Biochemistry; National Defense Medical Center ; Taipei; Taiwan, ROC.
Tsu-Chung
TC
Chang
RARRES3; Wnt/β-catenin pathway; protein acylation