Transcriptional regulation of long-term potentiation.
Long-term potentiation (LTP), the persistent strengthening of synapses following high levels of stimulation, is a form of synaptic plasticity that has been studied extensively as a possible mechanism for learning and memory formation. The strengthening of the synapse that occurs during LTP requires cascades of complex molecular processes and the coordinated remodeling of pre-synaptic and post-synaptic neurons. Despite over four decades of research, our understanding of the transcriptional mechanisms and molecular processes underlying LTP remains incomplete. Identification of all the proteins and non-coding RNA transcripts expressed during LTP may provide greater insight into the molecular mechanisms involved in learning and memory formation.
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Nicola
N
Bliim
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Iryna
I
Leshchyns'ka
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Vladimir
V
Sytnyk
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. m.janitz@unsw.edu.au.
Michael
M
Janitz
D000818:Animals; D001921:Brain / Q000378:metabolism; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D017774:Long-Term Potentiation / Q000235:genetics*; D008568:Memory / Q000502:physiology; D009474:Neurons / Q000378:metabolism; D022661:RNA, Untranslated / Q000235:genetics
D022661:RNA, Untranslated
Gene expression; Long-term potentiation; Non-coding RNAs; Synaptic plasticity; Transcriptome