Reactive oxygen species and tumor dissemination: Allies no longer.
For decades, reactive oxygen species (ROS) linked to oxidative stress have been suggested to promote carcinogenesis. However, we and others have demonstrated a protective role for ROS in metastatic dissemination. These recent studies partly explain the large failure observed in clinical trials using antioxidants for cancer prevention.
Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London , London SE1 1UL, UK.
Cecilia
C
Herraiz
Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London , London SE1 1UL, UK.
Eva
E
Crosas-Molist
Tumour Plasticity Laboratory, Randall Division of Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London , London SE1 1UL, UK.
Victoria
V
Sanz-Moreno
Amoeboid migration; DNA damage; P53; PIG3; RHO GTPases; ROCK; antioxidants; cancer metastasis; reactive oxygen species (ROS)