Difference in Bone Mineral Density Change at the Lateral Femoral Cortices according to Administration of Different Bisphosphonate Agents.
BACKGROUND
To retrospectively assess whether the response of subtrochanteric lateral cortex (STLC) is different according to the bisphosphonate agents in terms of bone mineral density (BMD) change.


METHODS
A total of 149 subjects, who had 2- to 4-year interval follow-up of BMD using dual energy X-ray absorptiometry (DXA), were included in this retrospective study divided into following 3 groups: control group (no consumption of any anti-osteoporotic drugs, n=38), alendronate group (naïve alendronate users, n=48), risedronate group (naïve risedronate users, n=63). BMD was measured at the STLC and subtrochanteric medial cortex (STMC) in each patient by drawing rectangular ROIs at the bone cortices. The percent change of BMD at the STLC were compared between the aforementioned 3 groups by using analysis of covariance model to control five independent variables of age, body mass index, percent change of STMC, hip axis length, time interval between DXA examinations.


RESULTS
The least square mean values±standard deviation of the percent change of BMD in the control, alendronate, and risedronate groups were 1.46±1.50, 2.23±1.26, and 6.96±1.11, respectively. The risedronate group showed significantly higher change of BMD percentage compared with the control (adjusted P=0.012) or alendronate (adjusted P=0.016) groups.


CONCLUSIONS
The percent change of BMD at the STLC in the risedronate user group was greater than the alendronate and control groups. The implication of these changes needs to be further verified.
Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Sungjun
S
Kim
Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu, Korea.
Hyun Hee
HH
Bang
Biostatistics Collaboration Lab, Yonsei University College of Medicine, Seoul, Korea.
Hanna
H
Yoo
Department of Orthopaedic Surgery, Kyungpook National University Hospital, Daegu, Korea.
Il Hyung
IH
Park
Department of Orthopedic Surgery, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Korea.
Kyu Hyun
KH
Yang
Department of Policy Research Affairs, National Health Insurance Service, Ilsan Hospital, Goyang, Korea.
Hyunsun
H
Lim
Department of Orthopedic Surgery, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Korea.
Woo Seok
WS
Jung
Alendronate; Bone density; Femur; Risedronate