Room-Temperature Gold-Catalysed Arylation of Heteroarenes: Complementarity to Palladium Catalysis.
Tailoring of the pre-catalyst, the oxidant and the arylsilane enables the first room-temperature, gold-catalysed, innate C-H arylation of heteroarenes. Regioselectivity is consistently high and, in some cases, distinct from that reported with palladium catalysis. Tolerance to halides and boronic esters, in both the heteroarene and silane partners, provides orthogonality to Suzuki-Miyaura coupling.
EaStCHEM, School of Chemistry, University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ, UK.
Alexander J
AJ
Cresswell
EaStCHEM, School of Chemistry, University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ, UK. Guy.Lloyd-Jones@ed.ac.uk.
Guy C
http://orcid.org/0000-0003-2128-6864
GC
Lloyd-Jones
C−H functionalisation; arylation; gold catalysis; heteroarenes; silicon