Synthesis of Substituted Oxazoles by Visible-Light Photocatalysis.
A simple and practical method for the synthesis of substituted oxazoles has been developed using readily available α-bromoketones and benzylamines by visible-light photocatalysis at room temperature. The process, which requires 1 mol % of [Ru(bpy)3]Cl2 photocatalyst with K3PO4 and CCl3Br, is effective for accessing a variety of valuable oxazole compounds. The synthetic utility of our protocol was also demonstrated by preparing a natural product, texaline.
Department of Chemistry, Chung-Ang University , 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea.
Tanmay
T
Chatterjee
Department of Chemistry, Chung-Ang University , 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea.
Ji Young
JY
Cho
Department of Chemistry, Chung-Ang University , 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea.
Eun Jin
EJ
Cho