Visible-Light-Mediated Synthesis of Amidyl Radicals: Transition-Metal-Free Hydroamination and N-Arylation Reactions.
The development of photoredox reactions of aryloxy-amides for the generation of amidyl radicals and their use in hydroamination-cyclization and N-arylation reactions is reported. Owing to the ease of single-electron-transfer reduction of the aryloxy-amides, the organic dye eosin Y was used as the photoredox catalyst, which results in fully transition-metal-free processes. These transformations exhibit a broad scope, are tolerant to several important functionalities, and have been used in the late-stage modification of complex and high-value N-containing molecules.
School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, U.K.
Jacob
J
Davies
School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, U.K.
Thomas D
TD
Svejstrup
School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, U.K.
Daniel
D
Fernandez Reina
Department of Chemistry, Faculty of Science, King Faisal University , Al-Ahsa 31982, Saudi Arabia.
Nadeem S
NS
Sheikh
School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, U.K.
Daniele
D
Leonori