Inverse Problem for Color Doppler Ultrasound-Assisted Intracardiac Blood Flow Imaging.
For the assessment of the left ventricle (LV), echocardiography has been widely used to visualize and quantify geometrical variations of LV. However, echocardiographic image itself is not sufficient to describe a swirling pattern which is a characteristic blood flow pattern inside LV without any treatment on the image. We propose a mathematical framework based on an inverse problem for three-dimensional (3D) LV blood flow reconstruction. The reconstruction model combines the incompressible Navier-Stokes equations with one-direction velocity component of the synthetic flow data (or color Doppler data) from the forward simulation (or measurement). Moreover, time-varying LV boundaries are extracted from the intensity data to determine boundary conditions of the reconstruction model. Forward simulations of intracardiac blood flow are performed using a fluid-structure interaction model in order to obtain synthetic flow data. The proposed model significantly reduces the local and global errors of the reconstructed flow fields. We demonstrate the feasibility and potential usefulness of the proposed reconstruction model in predicting dynamic swirling patterns inside the LV over a cardiac cycle.
Department of Computational Science and Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
Jaeseong
J
Jang
Division of Integrated Mathematics, National Institute for Mathematical Sciences, 70 Yuseong-daero 1689 beon-gil, Yuseong-gu, Daejeon 34047, Republic of Korea.
Chi Young
0000-0001-5207-8959
CY
Ahn
Department of Computational Science and Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
Jung-Il
0000-0002-4948-1250
JI
Choi
Department of Computational Science and Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
Jin Keun
0000-0002-6275-4938
JK
Seo
D000465:Algorithms; D001783:Blood Flow Velocity; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted; D018618:Echocardiography, Doppler, Color; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D018056:Hemorheology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008955:Models, Cardiovascular; D009038:Motion; D010363:Pattern Recognition, Automated; D012984:Software; D018615:Ultrasonography, Doppler, Color; D016277:Ventricular Function, Left / Q000502:physiology