Efficacy and safety of SQ house dust mite (HDM) SLIT-tablet treatment of HDM allergic asthma.
BACKGROUND
In the treatment of house dust mite (HDM) respiratory allergic disease, allergy immunotherapy constitutes an add-on treatment option targeting the underlying immunological mechanisms of allergic disease. However, for the treatment of HDM allergic asthma, the use of subcutaneous allergy immunotherapy (SCIT) has been limited by the risk of systemic adverse events. Thus, sublingually administered allergy immunotherapy (SLIT) has been investigated as a treatment option with an improved tolerability profile that allows for safer treatment of patients with HDM allergic asthma.


METHODS
In this Drug Profile, we provide a review of the clinical data behind the SQ HDM SLIT-tablet, which was recently approved for the treatment of HDM allergic asthma and allergic rhinitis by regulatory authorities in several European countries. Expert commentary: The SQ HDM SLIT-tablet is the first allergy immunotherapy to be tested prospectively in patients with asthma, and to favorably modify patient relevant end points such as requirement for inhaled corticosteroid (ICS) or the time to first asthma exacerbation upon ICS reduction, suggesting that SQ HDM SLIT-tablet treatment may contribute to improving overall asthma control.
a Allergy & Respiratory Diseases Clinic, DIMI , University of Genova , Genova , Italy.
Giorgio Walter
GW
Canonica
b Department of Pneumology/Intensive Care Medicine , University of Rostock , Rostock , Germany.
Johann Christian
JC
Virchow
c Allergy Center Vienna West , Vienna Challenge Chamber , Vienna , Austria.
Petra
P
Zieglmayer
d Global Clinical Development, ALK , Hørsholm , Denmark.
Christian
C
Ljørring
d Global Clinical Development, ALK , Hørsholm , Denmark.
Ida Mosbech
IM
Smith
e Allergy Clinic , Copenhagen University Hospital Gentofte , Hellerup , Denmark.
Holger
H
Mosbech
D000286:Administration, Sublingual; D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology / Q000627:therapeutic use*; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D003888:Desensitization, Immunologic / Q000379:methods*; D017277:Drug Approval; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000628:therapy*; D007279:Injections, Subcutaneous; D039981:Pyroglyphidae / Q000276:immunology*; D013607:Tablets; D016896:Treatment Outcome
D039741:Antigens, Dermatophagoides; D013607:Tablets
House dust mite; SLIT-tablet; allergic asthma; allergy immunotherapy; sublingual immunotherapy (SLIT)