Pregabalin: A New Adjunct in Calcineurin Inhibitor Pain Syndrome Treatment.
Tacrolimus and cyclosporin are calcineurin inhibitors (CIs) commonly used in organ transplants. These agents rarely cause a severe, debilitating pain syndrome of especially lower extremities, known as CI pain syndrome (CIPS). Although the pathogenesis is not well understood, neuropathic pain mechanisms have started to be discussed in the recent literature. Here, presenting a 48-year-old male with CIPS who recovered after pregabalin 150 mg twice daily, we aimed to emphasize the importance of this syndrome and offer a new approach for the treatment. This is the first report in the literature where pregabalin is demonstrated to be effective in CIPS.
Ankara Physical Medicine and Rehabilitation Education and Research Hospital, Ankara, Turkey ozlem81tasoglu@yahoo.com.
Özlem
Ö
Taşoğlu
Department of Gastroenterology, Ankara Yüksek İhtisas Education and Research Hospital, Ankara, Turkey.
Hale
H
Gökcan
Ankara Physical Medicine and Rehabilitation Education and Research Hospital, Ankara, Turkey.
Sibel Özbudak
SÖ
Demir
Ankara Physical Medicine and Rehabilitation Education and Research Hospital, Ankara, Turkey.
Didem
D
Yenigün
Department of Gastroenterology, Ankara Yüksek İhtisas Education and Research Hospital, Ankara, Turkey.
Meral
M
Akdoğan
Department of Gastroenterology, Ankara Yüksek İhtisas Education and Research Hospital, Ankara, Turkey.
Sabite
S
Kaçar
D000700:Analgesics / Q000627:therapeutic use*; D065095:Calcineurin Inhibitors / Q000009:adverse effects*; D016572:Cyclosporine; D006801:Humans; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation; D010146:Pain / Q000139:chemically induced*; D000069583:Pregabalin / Q000627:therapeutic use*; D016559:Tacrolimus
D000700:Analgesics; D065095:Calcineurin Inhibitors; D000069583:Pregabalin; D016572:Cyclosporine; D016559:Tacrolimus
musculoskeletal pain; neuropathic pain; organ transplantation