HIV-specific Th2 and Th17 responses predict HIV vaccine protection efficacy.
Understanding the factors that delineate the efficacy of T-cell responses towards pathogens is crucial for our ability to develop potent therapies and vaccines against infectious diseases, such as HIV. Here we show that a recently developed analytical tool, the polyfunctionality index (PI), not only enables prediction of protection after vaccination against HIV, but also allows identification of the immunological pathways involved. Our data suggest that induction of a synergistic network of CD4(+) T-cell subsets is implicated in HIV-protection. Accordingly, we provide evidence that vaccine-induced protection is associated with CD40L expressing Th2 cells and IL-2 secreting Th17 cells. In conclusion, we describe a novel approach that is widely applicable and readily interpretable in a biological and clinical context. This approach could greatly impact our fundamental understanding of T-cell immunity as well as the search for effective vaccines.
Sorbonne Universités, UPMC Univ Paris 06, INSERM, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris UMRS 1135), F75013, Paris, France.
Delphine
D
Sauce
Sorbonne Universités, UPMC Univ Paris 06, INSERM, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris UMRS 1135), F75013, Paris, France.|AP-HP, Groupement Hospitalier Pitié-Salpêtrière, Département d'Immunologie, F75013, Paris, France.
Guy
G
Gorochov
Sorbonne Universités, UPMC Univ Paris 06, INSERM, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris UMRS 1135), F75013, Paris, France.|AP-HP, Groupement Hospitalier Pitié-Salpêtrière, Département d'Immunologie, F75013, Paris, France.
Martin
M
Larsen
D016915:AIDS Vaccines / Q000276:immunology*; D023201:CD40 Ligand / Q000378:metabolism; D003627:Data Interpretation, Statistical; D005500:Follow-Up Studies; D015658:HIV Infections / Q000175:diagnosis* / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism; D008213:Lymphocyte Activation; D008962:Models, Theoretical; D011237:Predictive Value of Tests; D011379:Prognosis; D058504:Th17 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D014611:Vaccination
D016915:AIDS Vaccines; D007376:Interleukin-2; D023201:CD40 Ligand