Emerging role of CD300 receptors in regulating myeloid cell efferocytosis.
Engulfment of apoptotic cells is predominantly executed by phagocytes via the recognition of "eat me" signals like phosphatidylserine (PS). Various PS-specific receptors exist on phagocytes, including Tyro3, Axl, and MerTK receptor tyrosine kinases (TAMs), T-cell immunoglobulin and mucin domain containing 1 and 4 (TIM1/4), and the newly identified CD300 family. The aim of the present auto-commentary is to highlight recent findings regarding the Cd300lf and Cd300lb receptors and their emerging roles in the development of autoimmune disease.
Receptor Cell Biology Section; Laboratory of Immunogenetics; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Rockville, MD, USA.
Oliver H
OH
Voss
Receptor Cell Biology Section; Laboratory of Immunogenetics; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Rockville, MD, USA.
Linjie
L
Tian
Receptor Cell Biology Section; Laboratory of Immunogenetics; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Rockville, MD, USA.
Yousuke
Y
Murakami
Receptor Cell Biology Section; Laboratory of Immunogenetics; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Rockville, MD, USA.
John E
JE
Coligan
Receptor Cell Biology Section; Laboratory of Immunogenetics; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Rockville, MD, USA.
Konrad
K
Krzewski
CD300 receptors; apoptotic cells; autoimmune disease; efferocytosis; phosphatidylserine; professional phagocytes