Impact of Diarrhea on the Clinical Presentation and Outcome of Severe Pneumonia in Bangladeshi Children.
We compared clinical presentation and outcome of 225 children with severe pneumonia between those with and those without diarrhea. Having diarrhea was associated with metabolic acidosis (P < 0.001) and hypocalcemia (P = 0.002) on presentation, and with a fatal outcome: 20/113 (20%) died with diarrhea versus 3/112 (3%) without diarrhea. Diarrhea is an important comorbidity in Bangladeshi children with severe pneumonia requiring attention for improved case management.
From the *International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh; and †Centre for International Child Health, The University of Melbourne Department of Paediatrics, Murdoch Children's Research Institute and Intensive Care Unit, Royal Children's Hospital, Melbourne, Australia.
Mohammod Jobayer
MJ
Chisti
Trevor
T
Duke
Mohammed Abdus
MA
Salam
K M
KM
Shahunja
Abu S M S B
AS
Shahid
Pradip Kumar
PK
Bardhan
Abu S G
AS
Faruque
Tahmeed
T
Ahmed
D000138:Acidosis; D001459:Bangladesh / Q000453:epidemiology; D016022:Case-Control Studies; D002675:Child, Preschool; D003967:Diarrhea / Q000150:complications* / Q000453:epidemiology / Q000401:mortality*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011014:Pneumonia / Q000150:complications* / Q000453:epidemiology / Q000401:mortality*; D012307:Risk Factors; D016896:Treatment Outcome