Clinical value of serum trophoblast cell surface protein 2 (TROP2) antibody in non-small-cell lung cancer patients.
OBJECTIVE
This study was to explore the clinical role of serum trophoblast cell surface protein 2 (TROP2) antibody in patients with non-small-cell lung cancer (NSCLC).


METHODS
We collected serum specimens from 117 NSCLC patients, 40 benign lung disease patients, and 60 healthy controls. TROP2 antibody concentrations were measured using enzyme-linked immunosorbent assay.


RESULTS
Serum TROP2 antibody levels were higher in the NSCLC group compared to the control group (p < 0.001). TROP2 antibody, at a cutoff value of 9.8 U/ml, showed good diagnostic performance for NSCLC.


CONCLUSIONS
Measurement of TROP2 antibody might have diagnostic value for patients with NSCLC.
a Clinical Laboratory Center of Shaoxing People's Hospital , Shaoxing Hospital of Zhejiang University , Shaoxing , China.
Zhuan
Z
Zheng
a Clinical Laboratory Center of Shaoxing People's Hospital , Shaoxing Hospital of Zhejiang University , Shaoxing , China.
Xue-Jun
XJ
Dong
Antibodies; clinical value; non-small cell lung cancer; trophoblast cell surface protein 2