[A Case of Difficult-to-Diagnose Carcinomatous Meningitis Caused by Prostate Cancer Metastasis].
A 66-year-old man was referred to our hospital because of right leg pain. Computed tomography (CT) revealed multiple osteolytic changes. His serum prostate-specific antigen (PSA) level was increased to 77.83 ng/ml at the time of hospitalization. A prostate biopsy was performed, and histological examination results indicated poorly differentiated adenocarcinoma. Under the diagnosis of multiple bone metastasis of prostate cancer, androgen deprivation therapy was started. However, 1 month later, the patient was confused and lost appetite. Brain CT image demonstrated brain metastasis, and magnetic resonance image showed hydrocephalus. Although the patient underwent ventricular drainage because of a depressed level of consciousness, he died of primary disease complicated by pneumonia 3 months after the first visit. Perioperative cerebrospinal fluid cytological examination revealed adenocarcinoma cells. Therefore, a diagnosis of carcinomatous meningitis caused by prostate cancer metastasis was made.
The Department of Urology, Osaka Gyoumeikan Hospital.
Masatake
M
Shinohara
The Department of Urology, Nara Hospital Kinki University Faculty of Medicine.
Keisuke
K
Kiba
The Department of Urology, Osaka Gyoumeikan Hospital.
Atsushi
A
Yamada
The Department of Diagnostic Pathology, Nara Medical University.
Kinta
K
Hatakeyama
The Department of Neurosurgery, Yamamoto Third Hospital.
Yasunobu
Y
Mita
The Department of Urology, Osaka Gyoumeikan Hospital.
Toshihisa
T
Saka
The Department of Urology, Osaka Gyoumeikan Hospital.
Yoshihik
Y
Hirao
D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary*; D001932:Brain Neoplasms / Q000556:secondary; D006801:Humans; D008297:Male; D055756:Meningeal Carcinomatosis / Q000175:diagnosis* / Q000209:etiology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed