Relationship between trauma-induced coagulopathy and progressive hemorrhagic injury in patients with traumatic brain injury.
Progressive hemorrhagic injury (PHI) can be divided into coagulopathy-related PHI and normal coagu- lation PHI. Coagulation disorders after traumatic brain injuries can be included in trauma-induced coagulopathy (TIC). Some studies showed that TIC is associated with PHI and increases the rates of disability and mortality. In this review, we discussed some mechanisms in TIC, which is of great importance in the development of PHI, including tissue factor (TF) hypothesis, protein C pathway and thrombocytopenia. The main mechanism in the relation of TIC to PHI is hypocoagulability. We also reviewed some coagulopathy parameters and proposed some possible risk factors, predictors and therapies.
Department of Neurosurgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Jia
J
Liu
Heng-Li
HL
Tian
D001778:Blood Coagulation Disorders / Q000453:epidemiology / Q000209:etiology*; D000070642:Brain Injuries, Traumatic / Q000150:complications*; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006801:Humans; D015994:Incidence; D011486:Protein C / Q000502:physiology; D012307:Risk Factors; D013925:Thromboplastin / Q000502:physiology
D005338:Fibrin Fibrinogen Degradation Products; D011486:Protein C; C036309:fibrin fragment D; D013925:Thromboplastin