Cognitive Translation Using the Rodent Touchscreen Testing Approach.
The development of novel therapeutic avenues for the treatment of cognitive deficits in psychiatric and neurodegenerative disease is of high importance, yet progress in this field has been slow. One reason for this lack of success may lie in discrepancies between how cognitive functions are assessed in experimental animals and humans. In an attempt to bridge this translational gap, the rodent touchscreen testing platform is suggested as a translational tool. Specific examples of successful cross-species translation are discussed focusing on paired associate learning (PAL), the 5-choice serial reaction time task (5-CSRTT), the rodent continuous performance task (rCPT) and reversal learning. With ongoing research assessing the neurocognitive validity of tasks, the touchscreen approach is likely to become increasingly prevalent in translational cognitive research.
Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK. mh473@cam.ac.uk.
M
M
Hvoslef-Eide
Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
S R O
SR
Nilsson
Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
L M
LM
Saksida
Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
T J
TJ
Bussey
D000818:Animals; D001245:Association Learning / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D006801:Humans; D051379:Mice; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats; D011930:Reaction Time / Q000502:physiology*; D012193:Reversal Learning / Q000502:physiology*
Cognition; Human; Mouse; Rat; Touchscreen; Translation