Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells.
S-phase checkpoints are triggered in tumor cells in response to DNA replication stress caused by the tumor microenvironment or oncogenes. A recent report from our laboratory showed that tumor cells and more normal epithelial cells have a very different response to replication stress. In this Author's View, the implications of this finding are discussed.
Molecular Oncology Unit; Department of Oncology; University of Sheffield School of Medicine ; Sheffield, UK.
Mark
M
Meuth
ATM; CHK1; DNA damage response; DNA replication; S-phase checkpoints; cell fate