Plasma levels of soluble receptor for advanced glycation end products in Alzheimer's disease.
BACKGROUND
A decreased plasma level of soluble form of the receptor for advanced glycation end products (sRAGE) in patients with Alzheimer's disease (AD) has been reported. However, no evidence has shown whether the sRAGE plasma level of AD patients may differentiate from other types of dementia.


METHODS
Our study assessed sRAGE concentrations in the following 121 individuals in Chongqing area: 36 patients with AD, 12 with vascular dementia (VaD), 14 with mixed dementia (MD), 24 with other dementia (OD) including Parkinson's disease dementia, frontotemporal dementia, paralytic dementia and 35 cognitively normal controls. The total plasma level of sRAGE was determined using sandwich ELISA method.


RESULTS
sRAGE concentration in AD is significantly decreased compared with healthy controls. However, the receiver operating characteristic curve analysis of sRAGE between the AD and the control shows a low diagnostic accuracy.


CONCLUSIONS
Our results demonstrate that sRAGE may assist the diagnosis of AD from normal individuals, but cannot differentiate AD from VaD, MD or OD.
a 1 Chongqing Key Laboratory of Neurology, Department of Neurology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
Xiao-Yan
XY
Xu
a 1 Chongqing Key Laboratory of Neurology, Department of Neurology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
Chang-Qing
CQ
Deng
a 1 Chongqing Key Laboratory of Neurology, Department of Neurology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
Jian
J
Wang
a 1 Chongqing Key Laboratory of Neurology, Department of Neurology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
Xiao-Juan
XJ
Deng
b 2 Department of Gerontology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
Qian
Q
Xiao
c 3 Department of Geriatrics, Chongqing Mental Health Center , GeLeShan Branch, Chongqing , China.
Yuan
Y
Li
a 1 Chongqing Key Laboratory of Neurology, Department of Neurology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
Qi
Q
He
a 1 Chongqing Key Laboratory of Neurology, Department of Neurology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
Wen-Hui
WH
Fan
a 1 Chongqing Key Laboratory of Neurology, Department of Neurology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
Feng-Ying
FY
Quan
a 1 Chongqing Key Laboratory of Neurology, Department of Neurology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
Yao-Ping
YP
Zhu
a 1 Chongqing Key Laboratory of Neurology, Department of Neurology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
Ping
P
Cheng
a 1 Chongqing Key Laboratory of Neurology, Department of Neurology, The First Affiliated Hospital of Chongqing Medical University , Chongqing , China.
Guo-Jun
GJ
Chen
D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D000704:Analysis of Variance; D015140:Dementia, Vascular / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D012372:ROC Curve; D012044:Regression Analysis
D017127:Glycation End Products, Advanced
Alzheimer's disease; ELISA; dementia; diagnose; plasma level; sRAGE