Total Synthesis of (+)-Mesembrine Applying Asymmetric Gold Catalysis.
The total synthesis of enantiomerically pure (+)-mesembrine is described. The central pyrrolidine moiety incorporating a quaternary, all-carbon-substituted stereocenter was constructed employing an asymmetric gold-catalyzed cycloisomerization of a 1,4-diynamide.
Institute for Organic Chemistry and Macromolecular Chemistry, Universität Düsseldorf , Universitätsstr. 1, D-40225 Düsseldorf, Germany.
Michael
M
Spittler
Institute for Organic Chemistry and Macromolecular Chemistry, Universität Düsseldorf , Universitätsstr. 1, D-40225 Düsseldorf, Germany.
Kiril
K
Lutsenko
Institute for Organic Chemistry and Macromolecular Chemistry, Universität Düsseldorf , Universitätsstr. 1, D-40225 Düsseldorf, Germany.
Constantin
C
Czekelius