Molecular mimicry and autoimmune thyroid disease.
Hypothesized 40 years ago, molecular mimicry has been thereafter demonstrated as an extremely common mechanism by which microbes elude immune response and modulate biosynthetic/metabolic pathways of the host. In genetically predisposed persons and under particular conditions, molecular mimicry between microbial and human antigens can turn a defensive immune response into autoimmunity. Such triggering role and its pathogenetic importance have been investigated and demonstrated for many autoimmune diseases. However, this is not the case for autoimmune thyroid disease, which appears relatively neglected by this field of research. Here we review the available literature on the possible role of molecular mimicry as a trigger of autoimmune thyroid disease. Additionally, we present the results of in silico search for amino acid sequence homologies between some microbial proteins and thyroid autoantigens, and the potential pathogenetic relevance of such homologies. Relevance stems from the overlap with known autoepitopes and the occurrence of specific HLA-DR binding motifs. Bioinformatics data published by our group support and explain the triggering role of Borrelia, Yersinia, Clostridium botulinum, Rickettsia prowazekii and Helicobacter pylori. Our new data suggest the potential pathogenic importance of Toxoplasma gondii, some Bifidobacteria and Lactobacilli, Candida albicans, Treponema pallidum and hepatitis C virus in autoimmune thyroid disease, indicating specific molecular targets for future research. Additionally, the consistency between in silico prediction of cross-reactivity and experimental results shows the reliability and usefulness of bioinformatics tools to precisely identify candidate molecules for in vitro and/or in vivo experiments, or at least narrow down their number.
Department of Clinical and Experimental Medicine - Endocrinology, University of Messina, Messina, Italy.|Master Program on Childhood, Adolescent and Women's Endocrine Health, University of Messina, Messina, Italy.|Interdepartmental Program on Molecular & Clinical Endocrinology and Women's Endocrine Health, University Hospital, Policlinico G. Martino, Messina, Italy.
Salvatore
S
Benvenga
Department of Clinical and Experimental Medicine - Dermatology, University of Messina, Messina, Italy. f.guarneri@tiscali.it.
Fabrizio
F
Guarneri
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D019295:Computational Biology / Q000379:methods; D006801:Humans; D018716:Molecular Mimicry / Q000276:immunology* / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D013959:Thyroid Diseases / Q000276:immunology*
Amino acid sequence homology; Autoimmune thyroid disease; Bioinformatics; Molecular mimicry