Enhanced Precision of Nanoparticle Phototargeting in Vivo at a Safe Irradiance.
A large proportion of the payload delivered by nanoparticulate therapies is deposited not in the desired target destination but in off-target locations such as the liver and spleen. Here, we demonstrate that phototargeting can improve the specific targeting of nanoparticles to tumors. The combination of efficient triplet-triplet annihilation upconversion (TTA-UC) and Förster resonance energy transfer (FRET) processes allowed in vivo phototargeting at a safe irradiance (200 mW/cm(2)) over a short period (5 min) using green light.
Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School , 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
Qian
Q
Liu
Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School , 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
Weiping
W
Wang
Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School , 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
Changyou
C
Zhan
Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School , 300 Longwood Avenue, Boston, Massachusetts 02115, United States.|Institute of Advanced Materials, School of Materials Science & Engineering, Nanjing University of Posts and Telecommunications , 9 Wenyuan Road, Nanjing 210023, P. R. China.
Tianshe
T
Yang
Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School , 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
Daniel S
DS
Kohane
D000818:Animals; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D031541:Fluorescence Resonance Energy Transfer; D006801:Humans; D008027:Light; D008819:Mice, Nude; D053758:Nanoparticles; D009374:Neoplasms, Experimental / Q000188:drug therapy
Caged ligands; photocleavage; photon upconversion; photoresponsive binding; phototargeted nanoparticles