SIN3B, the SASP, and pancreatic cancer.
Cellular senescence is classically considered a tumor suppressive mechanism. In addition to having stably exited the cell cycle, senescent cells secrete inflammatory factors. We recently demonstrated that senescence correlates with accelerated cancer progression in a mouse model of pancreatic ductal adenocarcinoma. Here, we discuss the implications of this study.
Department of Biochemistry and Molecular Pharmacology and NYU Cancer Institute; New York University School of Medicine ; New York, NY, USA.
David J
DJ
Cantor
Department of Biochemistry and Molecular Pharmacology and NYU Cancer Institute; New York University School of Medicine ; New York, NY, USA.
Gregory
G
David
IL-1α; SASP; Sin3; pancreatic ductal adenocarcinoma; senescence