Dysregulation of HIF2α and autophagy in renal cell carcinoma.
Our recent study shows that autophagy collaborates with proteasomes to degrade endothelial PAS domain-containing protein 1 (EPAS1, also known as HIF2α) in a manner dependent on Von Hippel-Lindau (VHL) and sequestosome 1 (SQSTM1/p62). The genetic dysregulation of autophagy is a common feature of different subtypes of renal cell carcinoma (RCC).
Department of Genitourinary Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
Xian-De
XD
Liu
Department of Melanoma; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
Haifeng
H
Zhu
Department of Genitourinary Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
Adela
A
DePavia
Department of Genitourinary Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
Eric
E
Jonasch
HIF2α; VHL; autophagy; p53; p62; proteasome; renal cell carcinoma