Targeting the sumoylation pathway in cancer stem cells.
Cancer stem cells (CSCs) represent a subset of tumor cells with tumor-initiating potential. We recently demonstrated that inhibition of the sumoylation pathway cleared the CSC population and repressed the outgrowth of basal breast cancer xenografts. Targeting the sumoylation pathway offers a novel treatment strategy for basal breast cancer.
Department of Surgery; University of Iowa ; Iowa City, IA USA.
Maria V
MV
Bogachek
Department of Surgery; University of Iowa ; Iowa City, IA USA.
James P
JP
De Andrade
Department of Surgery; University of Iowa; Iowa City, IA USA; Department of Anatomy and Cell Biology; University of Iowa; Iowa City, IA USA; Department of Biochemistry; University of Iowa; Iowa City, IA USA.
Ronald J
RJ
Weigel
CD44; SUMO; TFAP2A; basal breast cancer; cancer stem cells; epithelial-mesenchymal transition; sumoylation