Pluripotency of Stem Cells from Human Exfoliated Deciduous Teeth for Tissue Engineering.
Stem cells from human exfoliated deciduous teeth (SHED) are highly proliferative pluripotent cells that can be retrieved from primary teeth. Although SHED are isolated from the dental pulp, their differentiation potential is not limited to odontoblasts only. In fact, SHED can differentiate into several cell types including neurons, osteoblasts, adipocytes, and endothelial cells. The high plasticity makes SHED an interesting stem cell model for research in several biomedical areas. This review will discuss key findings about the characterization and differentiation of SHED into odontoblasts, neurons, and hormone secreting cells (e.g., hepatocytes and islet-like cell aggregates). The outcomes of the studies presented here support the multipotency of SHED and their potential to be used for tissue engineering-based therapies.
Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore 119083.
Vinicius
V
Rosa
Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore 119083.
Nileshkumar
N
Dubey
Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, National University of Singapore, Singapore 119083.
Intekhab
I
Islam
Department of Conservative Dentistry, School of Dentistry, Chonbuk National University, Jeonju 54596, Republic of Korea.
Kyung-San
KS
Min
Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.
Jacques E
JE
Nör