The Molecular and Cellular Choreography of Appendage Regeneration.
Recent advances in limb regeneration are revealing the molecular events that integrate growth control, cell fate programming, and positional information to yield the exquisite replacement of the amputated limb. Parallel progress in several invertebrate and vertebrate models has provided a broader context for understanding the mechanisms and the evolution of regeneration. Together, these discoveries provide a foundation for describing the principles underlying regeneration of complex, multi-tissue structures. As such these findings should provide a wealth of ideas for engineers seeking to reconstitute regeneration from constituent parts or to elicit full regeneration from partial regeneration events.
DFG Research Center for Regenerative Therapies, Technische Universität Dresden Fetscherstrasse 105, 01307 Dresden, GERMANY. Electronic address: elly.tanaka@crt-dresden.de.
Elly M
EM
Tanaka
D000818:Animals; D005075:Biological Evolution; D004817:Epidermis / Q000294:innervation; D005121:Extremities / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D012038:Regeneration; D015398:Signal Transduction