Caspase-2 and the oxidative stress response.
Caspase-2, one of the earliest discovered caspases, has emerged as a multifunctional enzyme with roles that are not limited to cell death. It acts as a tumor suppressor, prevents genetic instability, and protects against aging by playing a crucial role in sensing alterations in cellular redox status and activating the antioxidant defense system. These apparent non-apoptotic functions, only discovered recently, emphasize the importance of this often-neglected protease.
Center for Cancer Biology; University of South Australia ; Adelaide, SA, Australia.
Sonia
S
Shalini
Center for Cancer Biology; University of South Australia ; Adelaide, SA, Australia.
Sharad
S
Kumar
aging; apoptosis; caspase; oxidative stress; reactive oxygen species