The role of glutathione peroxidase maternal serum level in late onset of severe preeclampsia.
OBJECTIVE
This study was done to investigate the association between maternal serum glutathione peroxidase (GP) and late onset of severe preeclampsia.


METHODS
Cross-sectional study was undertaken comparing normal pregnancy and severe preeclampsia at 37-42 weeks of gestational age. Maternal venous blood was taken to assess the level of GP.


RESULTS
Twenty normal pregnancy and 20 severe preeclampsia patients were investigated. The median (max-min) of GP level for preeclampsia was 4.31 (0.03-327.41) mU/mL significantly lower than in normal pregnancy 318.90 (6.46-694.11) mU/mL (p < 0.001). A receiver operating characteristics (ROC) analysis showed that the cutoff point for GP to differentiate between normal pregnancy and severe preeclampsia was 41.74 mU/mL. Multivariate analysis was done to investigate the impact of BMI and parity showed that a low level of GP will increase the risk of severe preeclampsia.


CONCLUSIONS
Low level of GP was associated with the diagnosis of severe preeclampsia.
a Obstetrics and Gynecology Department, Faculty of Medicine , Diponegoro University, Dr. Kariadi Hospital , Semarang , Central Java , Indonesia.
Julian
J
Dewantiningrum
a Obstetrics and Gynecology Department, Faculty of Medicine , Diponegoro University, Dr. Kariadi Hospital , Semarang , Central Java , Indonesia.
Alini
A
Hafiz
D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis*; D011247:Pregnancy; D012720:Severity of Illness Index; D055815:Young Adult
D005979:Glutathione Peroxidase
Glutathione peroxidase; late onset of preeclampsia; severe preeclampsia