The Tosca Registry: An Ongoing, Observational, Multicenter Registry for Chronic Heart Failure.
The ageing of the population in western countries, the continuous increase of the prevalence of chronic diseases, the frequent coexistence of several morbid conditions (comorbidity) requires health professionals and Institutions to face difficult challenges, including increasing costs, need for more effective and sustainable therapies, and organizational issues. The European Innovation Partnership on Active and Healthy Ageing aims at enabling European citizens to lead healthy, active and independent lives while ageing. We herein discuss some key concepts bearing a special significance in the light of the Partnership aims, and present research and educational projects active in our local environment. Among these, the multicentre project TOSCA (Trattamento Ormonale nello Scompenso CArdiaco) that, although primarily focused on the understanding of the interactions between hormones and chronic heart failure (CHF), is also aimed at developing more effective models of clinical care. We provide the scientific background and current stage of the project. In the context of a growing complexity of the patients' clinical management, the polipharmacy is a new arising challenge for clinicians, bearing direct economic, organizational and clinical implications. A better understanding, characterization and management of this issue represent an additional target of the TOSCA network.
IRCSS Policlinico San Donato Milanese, San Donato, Milano.
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Arcopinto
Dipartimento di Scienze Mediche Traslazionali, Università Federico II, Napoli.
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Salzano
Ospedale Santa Maria dell'Olmo, Cava de' Tirreni, Salerno.
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Ferrara
Dipartimento di Scienze Mediche Traslazionali, Università Federico II, Napoli.
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Bobbio
Pulmonary Hypertension Center, Thoraxclinic, University of Heidelberg, Germany.
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Marra
Dipartimento di Scienze Mediche Traslazionali, Università Federico II, Napoli.
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Abete
Dipartimento di Scienze Mediche Traslazionali, Università Federico II, Napoli.
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Stagnaro
Dipartimento di Scienze Mediche Traslazionali, Università Federico II, Napoli.
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Polizzi
Dipartimento di Scienze Mediche Traslazionali, Università Federico II, Napoli.
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Giallauria
Dipartimento di Scienze Mediche Traslazionali, Università Federico II, Napoli.
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Illario
CIRFF, Center of Pharmacoeconomics, Federico II University, Naples, Italy.
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Menditto
Dipartimento di Scienze Mediche Traslazionali, Università Federico II, Napoli.
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Vigorito
Ospedale Santa Maria dell'Olmo, Cava de' Tirreni, Salerno.
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Bossone
Dipartimento di Scienze Mediche Traslazionali, Università Federico II, Napoli.
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Cittadini
Registry; ageing; heart failure; hormones