Extracellular Matrix for Vocal Fold Lamina Propria Replacement: A Review.
The vocal folds (VFs) are exposed to a number of injurious stimuli that frequently lead to aberrant structural alterations and altered biomechanical properties that clinically manifest as voice disorders. Therapies to restore both structure and function of this delicate tissue are ideal. However, such methods have not been adequately developed. Our group and others hypothesize that tissue engineering and regenerative medicine approaches, previously described for other tissue systems, hold significant promise for the VFs. In this review, we explore the concept of tissue engineering as it relates to the VFs, as well as recent studies employing both naturally and synthetically derived biomaterials, including those from laryngeal and nonlaryngeal sources, in combination with stem cells for a tissue-engineered approach to VF repair.
1 UNC-Chapel Hill/NCSU Joint Department of Biomedical Engineering, North Carolina State University , Raleigh, North Carolina.|2 The New York Stem Cell Foundation Research Institute , New York, New York.
Emily A
EA
Wrona
3 Department of Otolaryngology-Head and Neck Surgery, NYU Voice Center, New York University School of Medicine , New York, New York.
Robert
R
Peng
3 Department of Otolaryngology-Head and Neck Surgery, NYU Voice Center, New York University School of Medicine , New York, New York.
Milan R
MR
Amin
3 Department of Otolaryngology-Head and Neck Surgery, NYU Voice Center, New York University School of Medicine , New York, New York.
Ryan C
RC
Branski
1 UNC-Chapel Hill/NCSU Joint Department of Biomedical Engineering, North Carolina State University , Raleigh, North Carolina.|2 The New York Stem Cell Foundation Research Institute , New York, New York.
Donald O
DO
Freytes
D005109:Extracellular Matrix; D006801:Humans; D009092:Mucous Membrane; D044968:Regenerative Medicine; D023822:Tissue Engineering; D014827:Vocal Cords
extracellular matrix; scaffold; vocal fold; voice