Invasive pneumococcal disease leads to activation and hyperreactivity of platelets.
Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Center for Tropical and Infectious Diseases (CENTRID), Diponegoro University-Dr. Kariadi Hospital, Semarang, Indonesia. Electronic address: Rahajeng.Tunjungputri@radboudumc.nl.
Rahajeng N
RN
Tunjungputri
Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Marien I
MI
de Jonge
Central Veterinary Institute, Part of Wageningen UR, Lelystad, The Netherlands.
Astrid
A
de Greeff
Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Saskia
S
van Selm
Central Veterinary Institute, Part of Wageningen UR, Lelystad, The Netherlands.
Herma
H
Buys
Central Veterinary Institute, Part of Wageningen UR, Lelystad, The Netherlands.
Jose F
JF
Harders-Westerveen
Central Veterinary Institute, Part of Wageningen UR, Lelystad, The Netherlands.
Norbert
N
Stockhofe-Zurwieden
Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands.
Rolf T
RT
Urbanus
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands.
Phillip G
PG
de Groot
Central Veterinary Institute, Part of Wageningen UR, Lelystad, The Netherlands.
Hilde E
HE
Smith
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Andre J
AJ
van der Ven
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Quirijn
Q
de Mast
D000818:Animals; D001792:Blood Platelets / Q000382:microbiology* / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D015539:Platelet Activation; D011008:Pneumococcal Infections / Q000097:blood* / Q000150:complications* / Q000473:pathology; D011018:Pneumonia, Pneumococcal / Q000097:blood / Q000150:complications / Q000473:pathology; D013296:Streptococcus pneumoniae / Q000302:isolation & purification / Q000502:physiology*; D013552:Swine
Infection; Myocardial infarction; Platelet activation; Platelets; Pneumonia; Streptococcus pneumoniae