S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis.
Initially discovered as abundant components of eukaryotic cell membranes, sphingolipids are now recognized as important bioactive signaling molecules that modulate a variety of cellular functions, including those relevant to cancer and immunologic, inflammatory, and cardiovascular disorders. In this review, we discuss recent advances in our understanding of the role of sphingosine-1-phosphate (S1P) receptors in the regulation of vascular function, and focus on how de novo biosynthesized sphingolipids play a role in blood pressure homeostasis. The therapeutic potential of new drugs that target S1P signaling is also discussed.
Department of Pathology and Laboratory Medicine, Center for Vascular Biology, Weill Cornell Medicine, Cornell University, New York, New York.
Anna
A
Cantalupo
Department of Pathology and Laboratory Medicine, Center for Vascular Biology, Weill Cornell Medicine, Cornell University, New York, New York and2039@med.cornell.edu.
Annarita
A
Di Lorenzo
D000818:Animals; D001794:Blood Pressure; D004730:Endothelium, Vascular / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008246:Lysophospholipids / Q000096:biosynthesis* / Q000378:metabolism*; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000378:metabolism; D014664:Vasodilation
D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D013110:Sphingosine