Functional innovation from changes in protein domains and their combinations.
Domains are the functional building blocks of proteins. In this work we discuss how domains can contribute to the evolution of new functions. Domains themselves can evolve through various mechanisms, altering their intrinsic function. Domains can also facilitate functional innovations by combining with other domains to make novel proteins. We discuss the mechanisms by which domain and domain combinations support functional innovations. We highlight interesting examples where changes in domain combination promote changes at the domain level.
Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: jonathan.lees@ucl.ac.uk.
Jonathan G
JG
Lees
Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK.
Natalie L
NL
Dawson
Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK.
Ian
I
Sillitoe
Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK.
Christine A
CA
Orengo
D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D000072417:Protein Domains; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*
D011506:Proteins