The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses.
GeneCards, the human gene compendium, enables researchers to effectively navigate and inter-relate the wide universe of human genes, diseases, variants, proteins, cells, and biological pathways. Our recently launched Version 4 has a revamped infrastructure facilitating faster data updates, better-targeted data queries, and friendlier user experience. It also provides a stronger foundation for the GeneCards suite of companion databases and analysis tools. Improved data unification includes gene-disease links via MalaCards and merged biological pathways via PathCards, as well as drug information and proteome expression. VarElect, another suite member, is a phenotype prioritizer for next-generation sequencing, leveraging the GeneCards and MalaCards knowledgebase. It automatically infers direct and indirect scored associations between hundreds or even thousands of variant-containing genes and disease phenotype terms. VarElect's capabilities, either independently or within TGex, our comprehensive variant analysis pipeline, help prepare for the challenge of clinical projects that involve thousands of exome/genome NGS analyses. © 2016 by John Wiley & Sons, Inc.
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.|These authors contributed equally to the paper.
Gil
G
Stelzer
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.|These authors contributed equally to the paper.
Naomi
N
Rosen
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.|LifeMap Sciences Ltd, Tel Aviv, Israel.
Inbar
I
Plaschkes
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Shahar
S
Zimmerman
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Michal
M
Twik
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Simon
S
Fishilevich
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Tsippi Iny
TI
Stein
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Ron
R
Nudel
LifeMap Sciences Ltd, Tel Aviv, Israel.
Iris
I
Lieder
LifeMap Sciences Ltd, Tel Aviv, Israel.
Yaron
Y
Mazor
LifeMap Sciences Ltd, Tel Aviv, Israel.
Sergey
S
Kaplan
LifeMap Sciences Ltd, Tel Aviv, Israel.|Toldot Genetics Ltd, Hod Hasharon, Israel.
Dvir
D
Dahary
LifeMap Sciences Inc, Marshfield, Massachusetts.
David
D
Warshawsky
LifeMap Sciences Inc, Marshfield, Massachusetts.
Yaron
Y
Guan-Golan
LifeMap Sciences Inc, Marshfield, Massachusetts.
Asher
A
Kohn
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Noa
N
Rappaport
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Marilyn
M
Safran
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.|Corresponding author.
Doron
D
Lancet
D057225:Data Mining / Q000379:methods*; D030541:Databases, Genetic; D023281:Genomics / Q000379:methods*; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D010641:Phenotype; D020543:Proteome; D017421:Sequence Analysis / Q000379:methods*; D012984:Software / Q000592:standards
D020543:Proteome
GeneCards; VarElect; bioinformatics; biological database; diseases; gene prioritization; human genes; integrated information retrieval; next generation sequencing