The PVT1-MYC duet in cancer.
Gain of 8q24, harboring the avian myelocytomatosis viral oncogene homolog (MYC), is a frequent mutation in cancers. Although MYC is the usual suspect in these cancers, the role of other co-gained loci remains mostly unknown. We have recently found that MYC partners with the adjacent long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1), which stabilizes MYC protein and potentiates its activity.
Department of Genetics; Cell Biology and Development; University of Minnesota, Twin Cities ; Minneapolis, MN, USA.
Yuen-Yi
YY
Tseng
Department of Genetics; Cell Biology and Development; University of Minnesota, Twin Cities; Minneapolis, MN, USA; Masonic Cancer Center; University of Minnesota, Twin Cities; Minneapolis, MN, USA.
Anindya
A
Bagchi
8q24.21; HCT116; MDA-MB-231; MYC; PVT1; SK-BR-3; TCGA; amplification; breast cancer; copy number gain