Does TGF-β play a role in degenerative temporomandibular joint diseases? A systematic review.
OBJECTIVE
The objective of this review was to assess the literature for evidence investigating the role of TGF-β in temporomandibular joint disease with osteoarthritis.


METHODS
An electronic and manual search was carried out on the databases, MEDLINE/PubMed, Cochrane Library, Web Of Science, and EMBASE, from 1975 to December 2015 by two independent evaluators to identify clinical and laboratory trials in English.


RESULTS
The search produced 693 records. Following a process of selection based on certain criteria, eight articles were included.


CONCLUSIONS
This systematic review suggests that TGF-β administration alone does not result in joint regeneration; other factors may be involved, such as TGF-β receptor expression ,and TGF-β receptor mutations that do not allow a correct transduction, resulting in TGF-β deficiency. The anabolism induced by this growth factor is also able to neutralize the catabolic processes that are elevated in osteoarthritis. Therefore, further studies are essential to determine how the concentration of TGF-β in the temporomandibular joints acts as a potential marker for the development of degenerative conditions.
a Department of Dentistry , Federal University of Rio Grande do Norte , Natal-RN , Brazil.
Giovanna de Fátima Alves
GFA
da Costa
a Department of Dentistry , Federal University of Rio Grande do Norte , Natal-RN , Brazil.
Rafaelly Domingos Campos
RDC
Souza
a Department of Dentistry , Federal University of Rio Grande do Norte , Natal-RN , Brazil.
Gabriela Monteiro
GM
de Araújo
a Department of Dentistry , Federal University of Rio Grande do Norte , Natal-RN , Brazil.
Bruno César de Vasconcelos
BCV
Gurgel
a Department of Dentistry , Federal University of Rio Grande do Norte , Natal-RN , Brazil.
Gustavo Augusto Seabra
GAS
Barbosa
a Department of Dentistry , Federal University of Rio Grande do Norte , Natal-RN , Brazil.
Patrícia Dos Santos
PDS
Calderon
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D016208:Databases, Factual; D006801:Humans; D008660:Metabolism; D009154:Mutation; D010003:Osteoarthritis / Q000378:metabolism*; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D013704:Temporomandibular Joint / Q000378:metabolism*; D013705:Temporomandibular Joint Disorders / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D015415:Biomarkers; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta
Degenerative; Osteoarthritis; Osteoarthrosis; Temporomandibular joint; Transforming growth factor beta (TGF-β)