Positive correlation between serum IGF-1 and HDL-C in type 2 diabetes mellitus.
OBJECTIVE
Dyslipidemia and low levels of high density lipoprotein cholesterol (HDL-C) can increase the risk of atherosclerosis development in people with type 2 diabetes mellitus (T2DM). This study aimed to investigate the correlation between serum HDL-C and insulin-like growth factor-1 (IGF-1), which are crucially involved inT2DM.


METHODS
Serum concentrations of IGF-1, total cholesterol, triglyceride, low density lipoprotein cholesterol, and HDL-C were measured in 498 participants with T2DM without any lipid-modifying medicine prior to study. Participants were divided into three groups according to the 25th and 75th percentile of IGF-1 levels: low IGF-1 group (G1), middle IGF-1 group (G2), and high IGF-1 group (G3), respectively. Serum levels of HDL-C were compared among the three groups.


RESULTS
G1 presented a higher body mass index and higher fasting plasma insulin (FINS) than G2 (P<0.05), yet a lower HDL-C than G2 (P<0.05). Moreover, HDL-C, postprandial blood glucose, FINS, postprandial plasma insulin (PINS), hip circumference ratio, glycated hemoglobin A1c were significantly lower in G3 than in G2 (P<0.05). After adjusting for age and gender, serum levels of IGF-1 were negatively correlated with age, duration of disease, waist circumference, FINS, PINS, and insulin resistance, but positively correlated with HDL-C. Each increase of 2.71ng/dl in IGF-I concentration was associated with an increase of 1.34mg/dl in HDL level.


CONCLUSIONS
IGF-1 serum level in people with T2DM is correlated positively with HDL-C.
Department of Endocrinology, 306 Hospital of PLA, Beijing 100101, China.
Xiaofei
X
Song
Internal Medicine 2, Dezhou People's Hospital, Shandong Province 253000, China.
Jiali
J
Teng
Department of Endocrinology, 306 Hospital of PLA, Beijing 100101, China.
Aihong
A
Wang
Department of Endocrinology, 306 Hospital of PLA, Beijing 100101, China.
Xiang
X
Li
Department of Endocrinology, 306 Hospital of PLA, Beijing 100101, China.
Jing
J
Wang
Department of Endocrinology, 306 Hospital of PLA, Beijing 100101, China. Electronic address: yanjunl@yeah.net.
Yanjun
Y
Liu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005215:Fasting / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin; D007334:Insulin-Like Growth Factor I
High density lipoprotein cholesterol; Insulin-like growth factor-1; Type 2 diabetes mellitus