Preconception perfluoroalkyl and polyfluoroalkyl substances and incident pregnancy loss, LIFE Study.
Equivocal findings are reported for perfluoroalkyl and polyfluoroalkyl substances (PFASs) and self-reported pregnancy loss. We prospectively assessed PFASs and pregnancy loss in a cohort comprising 501 couples recruited preconception and followed daily through 7 post-conception weeks. Seven PFASs were quantified: 2-N-ethyl-perfluorooctane sulfonamide acetate (Et-PFOSA-AcOH); 2-N-methyl-perfluorooctane sulfonamido acetate (Me-PFOSA-AcOH); perfluorodecanoate (PFDeA); perfluorononanoate (PFNA); perfluorooctane sulfonamide (PFOSA); perfluorooctane sulfonate (PFOS); and perfluorooctanoate (PFOA). Women used home pregnancy test kits. Loss denoted conversion from a positive to a negative pregnancy test, onset of menses or clinical confirmation (n=98; 28%). Chemicals were log transformed and rescaled by their standard deviations to estimate adjusted hazard ratios (HRs) and 95% confidence intervals. No significantly elevated HRs were observed for any PFASs suggesting no association with loss: Et-PFOSA-AcOH (1.04; 0.87, 1.23), Me-PFOSA-AcOH (0.79; 0.61, 1.00; p<0.05), PFDeA (0.83; 0.66, 1.04), PFNA (0.86; 0.70, 1.06), PFOSA (0.74; 0.50, 1.09), PFOS (0.81; 0.65, 1.00), and PFOA (0.93; 0.75, 1.16).
Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, United States. Electronic address: louisg@mail.nih.gov.
Germaine M Buck
GM
Louis
Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, United States.
Katherine J
KJ
Sapra
Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States.
Dana Boyd
DB
Barr
Glotech Inc., Rockville, MD, United States.
Zhaohui
Z
Lu
Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, United States.
Rajeshwari
R
Sundaram
D000022:Abortion, Spontaneous / Q000097:blood / Q000453:epidemiology*; D000328:Adult; D017738:Alkanesulfonic Acids / Q000097:blood*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005466:Fluorocarbons / Q000097:blood*; D006801:Humans; D015994:Incidence; D011247:Pregnancy; D012306:Risk; D055815:Young Adult
D017738:Alkanesulfonic Acids; D004785:Environmental Pollutants; D005466:Fluorocarbons
Cohort; Epidemiology; Miscarriage; Perfluoroalkyl; Perfluoroalkyl acids; Polyfluoroalkyl; Pregnancy loss; Reproductive toxicity