Regulation of hematopoietic progenitors by estrogens as a basis for new antileukemic strategies.
We recently reported that estrogens regulate survival, proliferation, and self-renewal of hematopoietic stem cells and progenitors via estrogen receptor-α activation. Through its proapoptotic effect on malignant progenitors, tamoxifen treatment blocks the development of JAK2 (V617F) -induced myeloproliferative neoplasms in mice and sensitizes MLL-AF9-induced leukemias to chemotherapy, without detrimental effects on normal hematopoiesis.
Department of Cardiovascular Development and Repair; Centro Nacional de Investigaciones Cardiovasculares ; Madrid, Spain.
Abel
A
Sánchez-Aguilera
Department of Cardiovascular Development and Repair; Centro Nacional de Investigaciones Cardiovasculares ; Madrid, Spain.
Simón
S
Méndez-Ferrer
JAK2; MLL-AF9; acute myeloid leukemia; estrogen receptors; estrogens; hematopoietic progenitor cells; hematopoietic stem cells; myeloproliferative neoplasms; selective estrogen receptor modulators; tamoxifen