Short-Spindled Cell Haemangioblastoma with CD34 Expression: New Histopathological Variant or Just a Stochastic Cytological Singularity?
Haemangioblastomas are neoplasms of uncertain histogenesis with cellular and reticular variants advocated in current lore. Herein we describe an intriguing cerebellar specimen with unusual traits including spindle cell morphology and CD34 positivity. A thirty-nine-year old man had an infratentorial tumour discovered incidentally and resected three times. In all the instances, histopathological diagnosis was haemangioblastoma; nonetheless, he had neither physical stigmata nor family history of von Hippel-Lindau disease. By histology, the lesion was composed of areas of conventional stromal cells admixed with territories populated by short-spindled cells packed in lobules, sometimes giving the appearance of gomitoli. Immunoperoxidase-coupled reactions confirmed the expression of inhibin A, neuron-specific enolase (NSE), PS100, and CD57 but also revealed focal immunolabeling for CD34, CD99, and FXIIIa. This case highlights the potential phenotypical diversity that can be found within these neoplasms. Rather than uncertain histogenesis, it may in fact reflect multiple lines of differentiation-histomimesis-prone to adopt unusual morpho- and immunophenotypes in a subset of haemangioblastomas.
Pathology Unit, Neuropathology Service, Mexico General Hospital, 06726 Cuauhtémoc, DF, Mexico.
Miguel Fdo
MF
Salazar
Pathology Unit, Neuropathology Service, Mexico General Hospital, 06726 Cuauhtémoc, DF, Mexico.
Paola Andrea
PA
Escalante Abril
Pathology Unit, Neuropathology Service, Mexico General Hospital, 06726 Cuauhtémoc, DF, Mexico.
María Verónica
MV
Velasco Vales
Pathology Unit, Neuropathology Service, Mexico General Hospital, 06726 Cuauhtémoc, DF, Mexico.
Celene
C
Martínez Ruiz
Pathology Unit, Neuropathology Service, Mexico General Hospital, 06726 Cuauhtémoc, DF, Mexico.
Erick
E
Gómez Apo
Pathology Unit, Neuropathology Service, Mexico General Hospital, 06726 Cuauhtémoc, DF, Mexico.
Laura G
LG
Chávez Macías