A prospective cohort study of the silk fibroin patch in chronic tympanic membrane perforation.
Silk fibroin patching has been used to repair acute tympanic membrane perforations. Here, we describe the advantages and outcomes of this technique for chronic tympanic membrane perforations.



Individual cohort study.



Forty patients were enrolled; half underwent perichondrium myringoplasty, and the silk fibroin patch technique was applied in the remaining patients. We compared the closure, otorrhea, and complication rates; closure time; postoperative hearing gain; and patient satisfaction between the two groups.



Demographic data (gender, site, age, duration, preoperative air-bone gap, and perforation size and location) were not significantly different between the two groups. The closure rates and times, complication rates, and postoperative hearing gains were also similar in both groups. The mean operative time, otorrhea rate, and complication rate were also significantly better in the silk fibroin patch group. The intraoperative dizziness scores were higher in the conventional perichondrium myringoplasty group.



Success rates were similar for the silk fibroin patch technique and conventional perichondrium myringoplasty; however, patching was an easier, faster procedure. Our results suggest that the silk fibroin patch technique is a suitable treatment for chronic tympanic membrane perforation.



2b Laryngoscope, 126:2798-2803, 2016.
Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, School of Medicine, Hallym University, Gangwon, South Korea.|Nano-Bio Regenerative Medical Institute, Hallym University, Gangwon, South Korea.
Jun Ho
JH
Lee
Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, School of Medicine, Hallym University, Gangwon, South Korea.|Nano-Bio Regenerative Medical Institute, Hallym University, Gangwon, South Korea.
Dong-Kyu
DK
Kim
Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, School of Medicine, Hallym University, Gangwon, South Korea.|Nano-Bio Regenerative Medical Institute, Hallym University, Gangwon, South Korea.
Hae Sang
HS
Park
Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, School of Medicine, Hallym University, Gangwon, South Korea.
Ju Yeon
JY
Jeong
Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, School of Medicine, Hallym University, Gangwon, South Korea.
Yeung Kyu
YK
Yeon
Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, School of Medicine, Hallym University, Gangwon, South Korea.
Vijay
V
Kumar
Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, School of Medicine, Hallym University, Gangwon, South Korea.
Sung Hee
SH
Bae
Nano-Bio Regenerative Medical Institute, Hallym University, Gangwon, South Korea.
Jung Min
JM
Lee
Nano-Bio Regenerative Medical Institute, Hallym University, Gangwon, South Korea.
Bo Mi
BM
Moon
Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, School of Medicine, Hallym University, Gangwon, South Korea.|Nano-Bio Regenerative Medical Institute, Hallym University, Gangwon, South Korea.
Chan Hum
CH
Park
D000328:Adult; D001301:Audiometry, Pure-Tone; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D005349:Fibroins / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009225:Myringoplasty / Q000009:adverse effects / Q000379:methods*; D017060:Patient Satisfaction; D011183:Postoperative Complications; D019736:Prostheses and Implants / Q000009:adverse effects; D018058:Tympanic Membrane Perforation / Q000601:surgery* / Q000628:therapy
D005349:Fibroins
Middle ear; fibroin; silk; tympanic membrane perforation