Abietane-type diterpenoids from the roots of Caryopteris mongolica and their cholinesterase inhibitory activities.
Eleven abietane-type diterpenoids and two known abietanes were isolated from the roots of Caryopteris mongolica, and their structures were characterized. The absolute configurations at C-5 and C-10 were determined from the NMR data, including from the nuclear Overhauser effect and CD spectra, and the absolute configuration of C-16 in the hydroxypropyl group was determined via a modified Mosher's method. Furthermore, the previously unknown absolute configuration of the C-15 of cyrtophyllone B was determined to be in an R-configuration using X-ray crystallography. To estimate the preventive effects of the isolates for neurodegenerative disease development, their inhibitory activities against acetylcholinesterase (AChE) from human erythrocytes and butyrylcholinesterase (BChE) from horse serum were evaluated.
Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai, 981-8558, Japan. Electronic address: murata-t@tohoku-mpu.ac.jp.
Toshihiro
T
Murata
School of Pharmaceutical Sciences, University of Shizuoka, 52-1, Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Yoshinobu
Y
Ishikawa
School of Engineering and Applied Sciences, National University of Mongolia, POB-617, Ulaanbaatar-46A, 14201, Mongolia.
Erdenebileg
E
Saruul
Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai, 981-8558, Japan; Mongolian University of Pharmaceutical Sciences, Sonsgolon's Road, Street 4/A, 20th Khoroo, Songinokhairkhan District, Ulaanbaatar, Mongolia.
Erdenechimeg
E
Selenge
Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai, 981-8558, Japan.
Kenroh
K
Sasaki
School of Pharmaceutical Sciences, University of Shizuoka, 52-1, Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Kaoru
K
Umehara
Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai, 981-8558, Japan.
Fumihiko
F
Yoshizaki
School of Engineering and Applied Sciences, National University of Mongolia, POB-617, Ulaanbaatar-46A, 14201, Mongolia.
Javzan
J
Batkhuu
D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry
D045784:Abietanes; D002800:Cholinesterase Inhibitors
Abietane; Acetylcholinesterase inhibitory activity; Butyrylcholinesterase inhibitory activity; Caryopteris mongolica; Diterpenoid; Lamiaceae; X-ray crystallography