Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia.
Sirtuin-1 (SIRT1) is associated with longevity and cell survival. Recently, we unveiled a new role of SIRT1 in hepatic ischemia/reperfusion (I/R) injury and identified a novel interaction between SIRT1 and mitochondrial outer membrane protein mitofusin-2 (MFN2), in which SIRT1-dependent deacetylation of MFN2 regulates mitochondria and autophagy in the liver.
Department of Surgery, University of Florida , Gainesville, FL, USA.
Lee
L
Sooyeon
Department of Surgery, University of Florida , Gainesville, FL, USA.
Kristina L
KL
Go
Department of Surgery, University of Florida , Gainesville, FL, USA.
Jae-Sung
JS
Kim
Autophagy; ischemia/reperfusion; mitochondria; mitofusin 2; sirtuin 1