Finding Robust Adaptation Gene Regulatory Networks Using Multi-Objective Genetic Algorithm.
Robust adaptation plays a key role in gene regulatory networks, and it is thought to be an important attribute for the organic or cells to survive in fluctuating conditions. In this paper, a simplified three-node enzyme network is modeled by the Michaelis-Menten rate equations for all possible topologies, and a family of topologies and the corresponding parameter sets of the network with satisfactory adaptation are obtained using the multi-objective genetic algorithm. The proposed approach improves the computation efficiency significantly as compared to the time consuming exhaustive searching method. This approach provides a systemic way for searching the feasible topologies and the corresponding parameter sets to make the gene regulatory networks have robust adaptation. The proposed methodology, owing to its universality and simplicity, can be used to address more complex issues in biological networks.
Hai-Peng
HP
Ren
Xiao-Na
XN
Huang
Jia-Xuan
JX
Hao
D000220:Adaptation, Biological / Q000235:genetics*; D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D053263:Gene Regulatory Networks / Q000235:genetics*; D056084:Genetic Fitness; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical