Positioning the cleavage furrow: All you need is Rho.
RhoA controls cleavage furrow formation during cell division, but whether RhoA suffices to orchestrate spatiotemporal dynamics of furrow formation is unknown. In this issue, Wagner and Goltzer (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201603025) show that RhoA activity can induce furrow formation in all cell cortex positions and cell cycle phases.
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158 Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158.
Zairan
Z
Liu
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158 Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158 orion.weiner@ucsf.edu.
Orion D
0000-0002-1778-6543
OD
Weiner
D000818:Animals; D002455:Cell Division / Q000502:physiology*; D048749:Cytokinesis / Q000502:physiology; D003593:Cytoplasm / Q000378:metabolism / Q000502:physiology; D008941:Spindle Apparatus / Q000378:metabolism* / Q000502:physiology*; D020742:rhoA GTP-Binding Protein / Q000378:metabolism*
D020742:rhoA GTP-Binding Protein