A Validated Normative Model for Human Uterine Volume from Birth to Age 40 Years.
Transabdominal pelvic ultrasound and/or pelvic Magnetic Resonance Imaging are safe, accurate and non-invasive means of determining the size and configuration of the internal female genitalia. The assessment of uterine size and volume is helpful in the assessment of many conditions including disorders of sex development, precocious or delayed puberty, infertility and menstrual disorders. Using our own data from the assessment of MRI scans in healthy young females and data extracted from four studies that assessed uterine volume using transabdominal ultrasound in healthy females we have derived and validated a normative model of uterine volume from birth to age 40 years. This shows that uterine volume increases across childhood, with a faster increase in adolescence reflecting the influence of puberty, followed by a slow but progressive rise during adult life. The model suggests that around 84% of the variation in uterine volumes in the healthy population up to age 40 is due to age alone. The derivation of a validated normative model for uterine volume from birth to age 40 years has important clinical applications by providing age-related reference values for uterine volume.
School of Computer Science, University of St Andrews, St Andrews KY16 9SX, United Kingdom.
Thomas W
http://orcid.org/0000-0002-8091-1458
TW
Kelsey
School of Medicine, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom.
Eleanor
E
Ginbey
Department of Paediatric Radiology, Royal Hospital for Sick Children, Edinburgh EH9 1LF, United Kingdom.
Moti M
MM
Chowdhury
Department of Endocrinology and Diabetes, Royal Hospital for Sick Children, Edinburgh EH9 1LF, United Kingdom.
Louise E
LE
Bath
MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom.
Richard A
RA
Anderson
Department of Haematology/Oncology, Royal Hospital for Sick Children, Edinburgh EH9 1LF, United Kingdom.
W Hamish B
WH
Wallace
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D009929:Organ Size; D012741:Sexual Maturation; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging* / Q000254:growth & development*; D055815:Young Adult