Glycerol-3-phosphate Dehydrogenase Inhibitors, Anacardic Acids, from Ginkgo biloba.
Four inhibitors of glycerol-3-phosphate dehydrogenase were isolated from Ginkgo biloba and identified as anacardic acids (6-tridecylsalicylic acid, 6-[(8Z)-pentadecenyl]salicylic acid, 6-[(9Z,12Z)-heptadecadienyl]salicylic acid, and 6-[(8Z)-heptadecenyl]salicylic acid) by instrumental analyses. Their 50% inhibitory concentrations against the enzyme were 1-3 μg/ml under the standard assay conditions. Anacardic acid inhibited the enzyme non-competitively. The sarcotesta contained most of anacardic acids, and nuts a little.
a Department of Nutrition and Food Chemistry , Ochanomizu University , 2-1-1 Otsuka, Bunkyo-ku Tokyo , 112 , Japan.
J
J
Irie
a Department of Nutrition and Food Chemistry , Ochanomizu University , 2-1-1 Otsuka, Bunkyo-ku Tokyo , 112 , Japan.
M
M
Murata
a Department of Nutrition and Food Chemistry , Ochanomizu University , 2-1-1 Otsuka, Bunkyo-ku Tokyo , 112 , Japan.
S
S
Homma
Ginkgo biloba; alkylsalicylic acid; anacardic acid; glycerol-3-phosphate dehydrogenase; inhibitor of glycerol-3-phosphate dehydrogenase