Chemoselective Dimerization of Phosphates.
A methodology for the synthesis of oligophosphate conjugates using phosphordiamidites is described. This strategy facilitates the straightforward preparation of C2-symmetric dinucleoside tri-, penta-, and heptaphosphates. Moreover, unsymmetric compounds such as thiamine adenosine triphosphate and thiamine cytidine triphosphate can be prepared. The material is used to study the inhibitory activity of thiaminylated nucleotides against adenosine diphosphate ribosyltransferases.
Alexandre
A
Hofer
Elia
E
Marques
Nicole
N
Kieliger
Sarah-Kirsten N
SK
Gatter
Sara
S
Jordi
Elena
E
Ferrari
Plant Biochemistry & Physiology Laboratory, Department of Botany and Plant Biology, University of Geneva , Quai E. Ansermet 30, 1211 Geneva, Switzerland.
Manuel
M
Hofmann
Plant Biochemistry & Physiology Laboratory, Department of Botany and Plant Biology, University of Geneva , Quai E. Ansermet 30, 1211 Geneva, Switzerland.
Teresa B
TB
Fitzpatrick
Michael O
MO
Hottiger
Institute of Organic Chemistry, Albert-Ludwigs-University Freiburg , Albertstr. 21, 79104 Freiburg i. B., Germany.
Henning J
HJ
Jessen