Alzheimer's disease prevention: A way forward.
This review proposes a more optimistic view of Alzheimer's disease (AD), in contrast to that contributed by the ageing of the population and the failure of potentially curative therapies (vaccines and others). Treatment failure is likely due to the fact that AD gestates in the brain for decades but manifests in old age. This review updates the concept of AD and presents the results of recent studies that show that primary prevention can reduce the incidence and delay the onset of the disease. Half of all cases of AD are potentially preventable through education, the control of cardiovascular risk factors, the promotion of healthy lifestyles and specific drug treatments. These approaches could substantially reduce the future incidence rate of this disease.
Imas12 (Instituto de Investigación Hospital Universitario 12 de Octubre), Madrid, España; Cátedra Extraordinaria de Alzheimer y enfermedades Neurodegenerativas, Departamento de Medicina, Facultad de Medicina, Universidad Complutense, Madrid, España; CIBERNED, Instituto de Investigación Carlos III, Madrid, España.
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Bermejo-Pareja
Imas12 (Instituto de Investigación Hospital Universitario 12 de Octubre), Madrid, España; Departamento de Neurología, Hospital Universitario 12 de Octubre, Madrid, España. Electronic address: laisset@hotmail.com.
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Llamas-Velasco
CIBERNED, Instituto de Investigación Carlos III, Madrid, España; Departamento de Neurología, Hospital Universitario 12 de Octubre, Madrid, España.
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Villarejo-Galende
Alzheimer's disease; Alzheimer's disease prevention trials; Alzheimer's syndrome; Demencia; Dementia; Enfermedad de Alzheimer; Ensayos de prevención de la enfermedad de Alzheimer; Factores de riesgo; Prevención de la demencia; Prevention of dementia; Risk factors; Síndrome de Alzheimer