Nonalcoholic fatty liver disease is associated with low-grade albuminuria in Chinese adults (change not displayed).
BACKGROUND
Nonalcoholic fatty liver disease (NAFLD) was associated with higher risk of cardiovascular disease (CVD). Low-grade albuminuria was recognized as an early indicator of CVD. Epidemiological studies investigating the association between NAFLD and low-grade albuminuria were limited.


OBJECTIVE
To determine whether NAFLD is independently associated with the presence of low-grade albuminuria in Chinese adults.


METHODS
A cross-sectional community-based population study was performed in 8270 Chinese adults aged 40 years or older.


METHODS
A first-voided early morning spot urine sample was obtained for urinary albumin and creatinine measurements. The highest quartile of urinary albumin-to-creatinine ratio was defined as low-grade albuminuria, after excluding the participants with micro- or macroalbuminuria. NAFLD was diagnosed by using ultrasonography findings after the exclusion of alcohol abuse and other liver diseases.


RESULTS
The prevalence of low-grade albuminuria was significantly higher in participants with NAFLD than in those without NAFLD (33.6% vs. 21.3% in men and 30.4% vs. 22.8% in women, respectively). Multivariate-adjusted logistic regression analysis revealed that NAFLD was significantly associated with increased odds ratio of low-grade albuminuria in men (odds ratio, 1.47; 95% CI, 1.16-1.87) after adjusting for multiple confounders. The significant association was not detected in women.


CONCLUSIONS
NAFLD was significantly associated with an increased risk of present low-grade albuminuria in middle-aged and elderly Chinese men.
From the State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.|Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
L
L
Lin
From the State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.|Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
J
J
Lu
From the State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.|Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
X
X
Huang
From the State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.|Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
L
L
Ding
From the State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.|Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
Y
Y
Huang
From the State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.|Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
P
P
Wang
From the State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.|Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
K
K
Peng
From the State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.|Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
D
D
Zhang
From the State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China cammon@vip.sina.com.|Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
Y
Y
Xu
From the State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.|Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
M
M
Xu
From the State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.|Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
Y
Y
Chen
From the State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.|Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
Y
Y
Bi
From the State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.|Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
W
W
Wang
From the State Key Laboratory of Medical Genomics, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China cammon@vip.sina.com.|Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.|Department of Research and Development, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China.
Y
Y
Xu
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D015415:Biomarkers / Q000652:urine; D002681:China / Q000453:epidemiology; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000453:epidemiology; D017678:Sex Distribution; D014463:Ultrasonography / Q000379:methods
D015415:Biomarkers; D003404:Creatinine