Under Pressure: Mechanical Stress Management in the Nucleus.
Cells are constantly adjusting to the mechanical properties of their surroundings, operating a complex mechanochemical feedback, which hinges on mechanotransduction mechanisms. Whereas adhesion structures have been shown to play a central role in mechanotransduction, it now emerges that the nucleus may act as a mechanosensitive structure. Here, we review recent advances demonstrating that mechanical stress emanating from the cytoskeleton can activate pathways in the nucleus which eventually impact both its structure and the transcriptional machinery.
Institut National de la Sant&#233; et de la Recherche M&#233;dicale, UMR 1087, l'institut du thorax, CNRS, UMR 6291, Universit&#233; de Nantes, 44000 Nantes, France. nejma.belaadi@univ-nantes.fr.
Néjma
N
Belaadi
Institut National de la Sant&#233; et de la Recherche M&#233;dicale, UMR 1209, Institute for Advanced Biosciences, CNRS UMR 5309, Universit&#233; Grenoble Alpes, 38041 Grenoble, France. julien.aureille@inserm.fr.
Julien
J
Aureille
Institut National de la Sant&#233; et de la Recherche M&#233;dicale, UMR 1209, Institute for Advanced Biosciences, CNRS UMR 5309, Universit&#233; Grenoble Alpes, 38041 Grenoble, France. christophe.guilluy@inserm.fr.
Christophe
C
Guilluy
LINC; lamin; lamina; mechanical stress; mechanotransduction; nucleoskeleton; nucleus