Imaging transporters: Transforming diagnostic and therapeutic development.
Molecular imaging allows noninvasive assessment of drug distribution across pharmacological barriers. Thus, it plays an increasingly important role in efforts to understand the interactions of molecules with membrane transporters during drug development and in clinical pharmacology. We describe established and emerging imaging modalities utilized for studying transporter expression and function. We further present examples of how molecular imaging could provide insights into the contribution of transporters to drug disposition and effects.
Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel.
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Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel.
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Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel. sarae@ekmd.huji.ac.il.|The David R. Bloom Centre for Pharmacy and Dr. Adolf and Klara Brettler Centre for Research in Molecular Pharmacology and Therapeutics at The Hebrew University of Jerusalem, Israel. sarae@ekmd.huji.ac.il.
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D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism*; D057054:Molecular Imaging / Q000379:methods*
D026901:Membrane Transport Proteins