Aiolos and Lymphocyte Mimicry in Lung Cancer.
Aggressive carcinomas tend to adopt behaviors normally restricted to lymphocytes, including anchorage-independent mobilization, response to chemokines, and modulation of local inflammatory conditions. In a recent study we identified the lymphocyte-restricted chromatin regulator Aiolos as an epigenetic driver of lymphocyte mimicry in lung cancer that links immune cell development to metastatic behavior.
Department of Internal Medicine, Pulmonary and Critical Care; University of Texas, Southwestern Medical Center; Dallas, TX USA.
Lance S
LS
Terada
Department of Immunology, Biochemistry, and Molecular Biology; 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics; Tianjin Key Laboratory of Medical Epigenetics; Tianjin Medical University; Tianjin , PR China.
Zhe
Z
Liu
Aiolos; IKZF3; Ikaros; Shc; anchorage independence; anoikis; lung cancer; lymphocyte; p66Shc