More challenges ahead-metabolic heterogeneity of pancreatic cancer stem cells.
Pancreatic cancer stem cells (CSCs) display a distinct metabolic phenotype based on their strong dependence on mitochondrial oxidative phosphorylation (OXPHOS) and limited metabolic plasticity. While suppression of MYC upstream of PGC-1α was the key determinant of this phenotype, we also identified a subset of CSCs with reduced mitochondrial content that showed resistance to mitochondrial targeting, but could be sensitized by inhibition of MYC.
Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London , UK.
Christopher
C
Heeschen
Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London , UK.
Patricia
P
Sancho
Cancer stem cells; metabolism; metformin; pancreatic ductal adenocarcinoma