Cytotoxic Labdane Diterpenes from Hedychium ellipticum Buch.-Ham. ex Sm.
In order to reveal the constituents and their biological activities, we carried out a phytochemical study on Hedychium ellipticum Buch.-Ham. ex Sm. (Zingiberaceae). Ten labdane diterpenoids (1-10) were isolated from the rhizomes of H. ellipticum for the first time. Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their antimycobacterial activity against Mycobacterium tuberculosis and cytotoxicity against KB, MCF7, NCI-H187 and Vero cells. The result showed that compounds 1 and 7 exhibited moderate activity against Mycobacterium tuberculosis and compounds 4, 6 and 7 displayed remarkable cytotoxic activity. This is the first report on the presence of all compounds in H. ellipticum and the first time that their structure activity relationship has been discussed.
Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand. n_boxtree@hotmail.com.
Sineenard
S
Songsri
Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand. nuchnipa.n@cmu.ac.th.
Nuchnipa
N
Nuntawong
D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000008:administration & dosage / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D013329:Structure-Activity Relationship; D014709:Vero Cells / Q000187:drug effects; D030521:Zingiberaceae / Q000737:chemistry*
D004224:Diterpenes; D010936:Plant Extracts; C433017:labdane
Hedychium ellipticum; antimycobacterial activity; cytotoxic activity; labdane-type diterpene