Proliferating Cells Conserve Nitrogen to Support Growth.
Glutamate provides a large intracellular pool of carbon and nitrogen. Coloff et al. (2016) find that proliferating cells shift from a nitrogen-wasting to a nitrogen-sparing mode of glutamate catabolism, highlighting the exquisite tethering of proliferative signals to metabolism.
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-8502, USA. Electronic address: ralph.deberardinis@utsouthwestern.edu.
Ralph J
RJ
DeBerardinis
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009584:Nitrogen / Q000494:pharmacology*
D018698:Glutamic Acid; D004247:DNA; D005969:Glutamate Dehydrogenase; D009584:Nitrogen