Effectiveness of laparoscopic sleeve gastrectomy for weight loss and obesity-associated co-morbidities: a 3-year outcome from Mainland Chinese patients.
BACKGROUND
Laparoscopic sleeve gastrectomy (LSG) is becoming a stand-alone bariatric surgery for obesity, but its effectiveness for Mainland Chinese patients remains unclear.


OBJECTIVE
To evaluate the effectiveness and safety of LSG for Mainland Chinese patients SETTING: A tertiary hospital METHODS: Retrospective analysis of patients admitted for LSG between January 2011 and February 2012 was performed. Medium-term outcome measures were: total weight loss (%TWL), excess weight loss (%EWL), co-morbidities, improvement, and complications.


RESULTS
Seventy patients (body mass index [BMI] 40.8±5.9 kg/m2) underwent LSG, comprising 40 women and 30 men. The most common co-morbidity was diabetes (n = 29, 41.4%). Lost to follow-up rate for weight loss was 15.7%, 31.4%, and 41% at 1, 2, and 3 years. The %TWL was 34.4±6.1, 34.7±6.2 and 33.7±7.1 at 1, 2, and 3 years. The %EWL increased to 77.1±13.0, 77.9±12.2 and 77.2±13.1 at 1, 2, and 3years. The proportions of patients having successful weight loss were 100% or 85% at 3 years according the definition of %TWL>10% or %EWL>50%. Approximately 79.3%, 51.7%, and 44.8% of patients completed follow-up for glycemic control at each time point, respectively. The proportions of patients with optimal glycemic control (fasting blood glucose [FBG]<5.6 mmol/L; hemoglobin A1C [HbA1C]<6.5%) were 47.9%, 60.0%, and 69.2% at 1, 2, and 3years. The weight loss and glycemic control effect may be greater in the high BMI group (≥40 kg/m2). Early and late complications occurred in 8.6% and 7.1% of patients during follow-up.


CONCLUSIONS
LSG is effective in weight loss and glycemic control and is safe for Mainland Chinese obese patients, especially for patients with a BMI≥40 kg/m2.
Department of General Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China; Department of Gynaecology and Obstetrics, The 306 Hospital of PLA, Beijing 100037, China.
Xin
X
Wang
Department of General Surgery, Yancheng City First People's Hospital, Jiangsu 224000, China.
Xu-Sheng
XS
Chang
Department of Pathology and Pathophysiology, Dalian Medical University, Liaoning 10008, China.
Lin
L
Gao
Department of General Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
Cheng-Zhu
CZ
Zheng
Department of General Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
Xin
X
Zhao
Department of General Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
Kai
K
Yin
Department of General Surgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China. Electronic address: guodhhdhf@163.com.
Guo-En
GE
Fang
D000293:Adolescent; D000328:Adult; D050110:Bariatric Surgery / Q000379:methods*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002681:China / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000208:ethnology; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects / Q000379:methods*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000208:ethnology / Q000601:surgery*; D011183:Postoperative Complications / Q000208:ethnology / Q000209:etiology; D012189:Retrospective Studies; D016896:Treatment Outcome; D015431:Weight Loss / Q000208:ethnology / Q000502:physiology; D055815:Young Adult
D001786:Blood Glucose; D006442:Glycated Hemoglobin
Mainland Chinese patients; laparoscopic sleeve gastrectomy; obesity