Benign intestinal glandular lesions in the vagina: a possible correlation with implantation.
BACKGROUND
Enteric-type glandular lesions are extremely rare in the vagina. Their histological origin remains a matter of speculation at present.


METHODS
We review two rectal mucosal prolapse-like polyps and one intestinal-type adenosis in the vagina.


RESULTS
Case 1, a 64-year-old woman, presented with a vaginal polypoid lesion with a size of 4 × 3 × 3 cm. Case 2, an 8-year-old girl, had a 1.5 × 1.5 × 0.8-cm pedunculated polyp in the vaginal navicular fossa and a clinically suspected rectovaginal fistula. Case 1 and 3 had an obsolete severe perineal laceration. On histopathological examination, cases 1 and 2 resembled rectal mucosal prolapse or inflammatory cloacogenic polyp (rectal mucosal prolapse-like polyp). Case 3 had an incidental intestinal-type adenosis in the removed vaginal wall. Immunohistochemistry confirmed the intestinal differentiation in all 3 lesions by showing diffuse CDX2-positive, CK20-positive, and scattered chromogranin A-positive neuroendocrinal cells in the lower compartment of the crypt.


CONCLUSIONS
In summary, we report herein three unusual cases of benign intestinal-type glandular lesions in the vagina including two rectal mucosal prolapse-like polyps and one case of intestinal-type adenosis, and discuss possibilities for their histogenetic basis.
Department of Surgical Pathology, Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, Zhejiang Province, People's Republic of China.
Weiwei
W
Lu
Department of Surgical Pathology, Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, Zhejiang Province, People's Republic of China.
Xiaofei
X
Zhang
Department of Surgical Pathology, the Affiliated Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, Zhejiang Province, People's Republic of China. lbj@zju.edu.cn.
Bingjian
B
Lu
D014408:Biomarkers, Tumor / Q000378:metabolism*; D000071616:CDX2 Transcription Factor / Q000378:metabolism; D002454:Cell Differentiation; D002648:Child; D053379:Chromogranin A / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000473:pathology; D053554:Keratin-20 / Q000378:metabolism; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D011127:Polyps / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D012005:Rectal Prolapse / Q000473:pathology; D016896:Treatment Outcome; D014621:Vagina / Q000473:pathology; D014625:Vaginal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery
D014408:Biomarkers, Tumor; D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; C506150:CHGA protein, human; D053379:Chromogranin A; C507499:KRT20 protein, human; D053554:Keratin-20
Adenosis; Cloacogenic; Intestine; Polyp; Vagina