The Current and Evolving Role of PET in Personalized Management of Lung Cancer.
Using tumor genomic profiling information has revolutionized the landscape of personalized treatment of lung cancer. The management of lung cancer and non-small cell lung cancer particularly is influenced by discoveries of activating mutations in epidermal growth factor receptor and targeted therapies with tyrosine kinase inhibitors, fusion genes involving anaplastic lymphoma kinase, and targeted therapies for Kristen-Rat-Sarcoma and MET protooncogenes. PET imaging plays an important role in assessing the biologic behavior of lung cancer and defining response to therapy. This review summarizes genomic discoveries in lung cancer and their implications for functional PET imaging.
Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, USA.
Esther
E
Mena
Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, USA.
Anusha
A
Yanamadala
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Gang
G
Cheng
Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Centre, Johns Hopkins School of Medicine, 401 North Broadway, Baltimore, MD 21231, USA; Armstrong Institute for Patient Safety & Quality, Johns Hopkins School of Medicine, 750 East Pratt Street, Baltimore, MD 21202, USA; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 624 North Broadway, Baltimore, MD 21205, USA. Electronic address: rsubram4@jhmi.edu.
Rathan M
RM
Subramaniam
D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods* / Q000639:trends; D057285:Precision Medicine / Q000379:methods*
Genomics; Lung cancer; Management; PET/CT imaging; Personalized medicine