Attenuated Lead Induced Apoptosis in Rat Hepatocytes in the Presence of Lycopersicon Esculentum.
Lead (Pb), has, for decades, being known for its adverse effects on various body organs and systems. In the present study, the damage of Pb on the Liver tissue apoptosis was investigated, and Lycopersicon esculentum as an antioxidants source was administered orally to prevent the adverse effects of Pb. Eighteen Wistar rats, randomized into three groups (n=6), were used for this study. Animals in Group A served as the control and were drinking distilled water. Animals in Groups B and C were drinking 1%Lead acetate (LA). Group C animals were, in addition to drinking LA, treated with 1.5 ml/day of Lycopersicon esculentum. Treatments were for three months. The obtained results showed that lead acetate caused significant reductions in the liver weight, plasma and tissue superoxide dismutase and catalase activity, but a significant increase in plasma and tissue malondialdehyde concentration but Lycopersicon esculentum have an inhibitory effect on LA liver adverse effect. So, it can be concluded that Lycopersicon esculentum have a significant protective effect on liver lead acetate adverse effects as well as, lead acetate-induced oxidative stress.
Cosmetic Products Research Center, Iran Food and Drug Adminstration, Ministry of Health and Medical Education, Tehran, Iran. AND Department of Basic Sciences, School of Veterinary Medicine, University of Tehran, Iran. AND Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
Hamidreza
H
Ahmadi Ashtiani
Department of Pathology, Faculty of Veterinary, Islamic Azad University, Tabriz, Iran.
Arash
A
Khaki
Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran.
Shahram
S
Ejtemaei Mehr
Health Reference Laboratories, Ministry of Health and Medical Education, Tehran, Iran.
Soghra
S
Anjarani
Cosmetic Products Research Center, Iran Food and Drug Adminstration, Ministry of Health and Medical Education, Tehran, Iran.
Manochehr
M
Dadgarnejad
Cosmetic Products Research Center, Iran Food and Drug Adminstration, Ministry of Health and Medical Education, Tehran, Iran.
Mahmoud
M
Alebouyeh
Cosmetic Products Research Center, Iran Food and Drug Adminstration, Ministry of Health and Medical Education, Tehran, Iran. AND Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
Hossein
H
Rastegar
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D022781:Hepatocytes / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D018551:Solanum lycopersicum / Q000737:chemistry*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009942:Organometallic Compounds / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D009942:Organometallic Compounds; D008315:Malondialdehyde; D013482:Superoxide Dismutase; C008261:lead acetate
Apoptosis; Hepatocytes; Lead; Lycopersicon