Emerging role of adipokines in systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by multisystem organ involvement and unclear pathogenesis. Several adipokines synthesized in the adipose tissue, including leptin, adiponectin, resistin, and chemerin, have been explored in autoimmune rheumatic diseases, especially SLE, and results suggest that these mediators may be implicated in the pathogenesis of SLE. However, the current results are controversial. In this review, we will briefly discuss the expression and possible pathogenic role of several important adipokines, including leptin, adiponectin, resistin, and chemerin in SLE.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.|Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Hefei, People's Republic of China.
Hong-Miao
HM
Li
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.|Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Hefei, People's Republic of China.
Tian-Ping
TP
Zhang
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.|Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Hefei, People's Republic of China.
Rui-Xue
RX
Leng
Department of Rheumatology, Anhui Provincial Hospital, Hefei, People's Republic of China.
Xiang-Pei
XP
Li
Department of Rheumatology, Anhui Provincial Hospital, Hefei, People's Republic of China.
Xiao-Mei
XM
Li
Graduate School, Wannan Medical College, West of Wenchang Road, University Park, Wuhu, 241002, Anhui, People's Republic of China.
Hai-Rong
HR
Liu
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.|Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Hefei, People's Republic of China.
Dong-Qing
DQ
Ye
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China. panhaifeng1982@sina.com.|Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, Hefei, People's Republic of China. panhaifeng1982@sina.com.
Hai-Feng
HF
Pan
D054392:Adipokines / Q000276:immunology / Q000378:metabolism*; D052242:Adiponectin / Q000378:metabolism; D000273:Adipose Tissue / Q000276:immunology*; D000818:Animals; D018925:Chemokines / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000628:therapy; D058990:Molecular Targeted Therapy; D052243:Resistin / Q000378:metabolism
D054392:Adipokines; D052242:Adiponectin; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; C478630:RARRES2 protein, human; D052243:Resistin
Adipokines; Adiponectin; Leptin; Resistin; Systemic lupus erythematosus