When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer.
The APOBEC3 cytidine deaminases play an important role in innate immunity but have also emerged as mediators of somatic mutations in human cancer. We recently reported a high incidence of APOBEC-mediated driver mutations in human papillomavirus-associated cancer, suggesting a key role for these enzymes in the development of such tumors.
Bill Lyons Informatics Centre; UCL Cancer Institute; University College London; London, UK.
Stephen
S
Henderson
Department of Oncology; UCL Cancer Institute; University College London; London, UK.
Ankur
A
Chakravarthy
Department of Oncology; UCL Cancer Institute; University College London; London, UK.
Tim
T
Fenton
APOBEC; HPV; PIK3CA; cancer; mutagenesis