Association of Lipid Accumulation Product with Cardio-Metabolic Risk Factors in Postmenopausal Women.
The lipid accumulation product is a novel, safe and inexpensive index of central lipid over accumulation based on waist circumference and fasting concentration of circulating triglycerides. This study was designed to investigate the ability of lipid accumulation product to predict Cardio-metabolic risk factors in postmenopausal women. In this Cross-sectional study, 264 postmenopausal women by using convenience sampling method were selected from menopause clinic in Tehran. Cardio-metabolic risk factors were measured, and lipid accumulation product (waist-58×triglycerides [nmol/L]) was calculated. Optimal cut-off point of lipid accumulation product for predicting metabolic syndrome was estimated by ROC (Receiver-operating characteristic) curve analysis. Metabolic syndrome was diagnosed in 41.2% of subjects. Optimal cut-off point of lipid accumulation product for predicting metabolic syndrome was 47.63 (sensitivity:75%; specificity:77.9%). High lipid accumulation product increases risk of all Cardio-metabolic risk factors except overweight, high Total Cholesterol, high Low Density Lipoprotein Cholesterol and high Fasting Blood Sugar in postmenopausal women. Our findings show that lipid accumulation product is associated with metabolic syndrome and some Cardio-metabolic risk factors Also lipid accumulation product may have been a useful tool for predicting cardiovascular disease and metabolic syndrome risk in postmenopausal women.
Department of Gerontology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Alireza
A
Namazi Shabestari
Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. AND Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mojgan
M
Asadi
Obesity and Eating Habit Research Center, Endocrinology and Metabolism Institute, Tehran University of Medical Sciences, Tehran, Iran.
Zahra
Z
Jouyandeh
Department of Medicine, School of Medicine, Karaj University of Medical Sciences, Alborz, Iran. AND Department of Epidemiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mostafa
M
Qorbani
Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Roya
R
Kelishadi
D000328:Adult; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D064237:Lipid Accumulation Product / Q000502:physiology*; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D008875:Middle Aged; D017698:Postmenopause / Q000378:metabolism*; D012372:ROC Curve; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides
Cardio-metabolic syndrome; Lipid accumulation product; Menopause; Metabolic syndrome