Continuous-Flow Synthesis and Derivatization of Aziridines through Palladium-Catalyzed C(sp(3) )-H Activation.
A continuous-flow synthesis of aziridines by palladium-catalyzed C(sp(3) )-H activation is described. The new flow reaction could be combined with an aziridine-ring-opening reaction to give highly functionalized aliphatic amines through a consecutive process. A predictive mechanistic model was developed and used to design the C-H activation flow process and illustrates an approach towards first-principles design based on novel catalytic reactions.
Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge, CB2 3RA, UK.
Jacek
J
Zakrzewski
Chemistry Department, University of Cambridge, Lensfield Rd, Cambridge, CB2 1EW, UK.
Adam P
0000-0001-5120-8678
AP
Smalley
Chemistry Department, University of Cambridge, Lensfield Rd, Cambridge, CB2 1EW, UK.
Mikhail A
MA
Kabeshov
Chemistry Department, University of Cambridge, Lensfield Rd, Cambridge, CB2 1EW, UK. mjg32@cam.ac.uk.
Matthew J
0000-0002-7214-608X
MJ
Gaunt
Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge, CB2 3RA, UK. aal35@cam.ac.uk.
Alexei A
0000-0001-7621-0889
AA
Lapkin
C−H activation; aziridines; continuous-flow synthesis; palladium catalysis; ring opening