Fbw7 and Usp28 - enemies and allies.
The Usp28 deubiquitinase antagonizes Fbw7-mediated turnover of multiple oncoproteins, including Myc, Jun, and Notch, and promotes tumorigenesis in the intestine. Our recent study reveals that Usp28 also counteracts autocatalytic ubiquitination of Fbw7, suggesting a complex role for Usp28 in the regulation of Fbw7 activity and tumor development.
Comprehensive Cancer Center Mainfranken and Department of Radiation Oncology; University Hospital Würzburg ; Würzburg, Germany.
Lyudmyla
L
Taranets
Comprehensive Cancer Center Mainfranken and Department of Radiation Oncology; University Hospital Würzburg ; Würzburg, Germany.
Jing
J
Zhu
Comprehensive Cancer Center Mainfranken and Department of Radiation Oncology; University Hospital Würzburg ; Würzburg, Germany.
Wenshan
W
Xu
Comprehensive Cancer Center Mainfranken and Department of Radiation Oncology; University Hospital Würzburg ; Würzburg, Germany.
Nikita
N
Popov
Fbw7; SCF; Usp28; oncogene; tumor suppressor; ubiquitin