Lon protease: A key enzyme controlling mitochondrial bioenergetics in cancer.
We have recently explored the in vivo functional and oncologic relevance of Lon protease (LONP1), an enzyme involved in mitochondrial quality control. We found that LONP1 is an essential protein for life and that it also performs a critical function in tumorigenesis by regulating the bioenergetics of cancer cells.
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología; Universidad de Oviedo ; Oviedo, Spain.
Pedro M
PM
Quirós
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología; Universidad de Oviedo ; Oviedo, Spain.
Clea
C
Bárcena
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología; Universidad de Oviedo ; Oviedo, Spain.
Carlos
C
López-Otín
OXPHOS; aging; cancer; degradome; mitochondrial quality control