Facile synthesis of acacetin and its derivatives.
Acacetin, a O-methylated bioflavonoid isolated from the traditional Chinese medicine Xuelianhua (Saussurea tridactyla), is a promising orally effective atrium-selective antiarrhythmic agent for the treatment of atrial fibrillation (AF). Here we describe an efficient two-component method for the synthesis of acacetin and its derivatives.
China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 200120, China.
Yuan
Y
Zhao
Division of Mathematics and Science, University of South Carolina Salkehatchie, Walterboro, SC 29488, United States. Electronic address: CAILI@mailbox.sc.edu.
Li
L
Cai
China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 200120, China.
Qiang
Q
Sui
China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 200120, China.
Feng
F
Lin
China National Pharmaceutical Industry Information Center, 1320 West Beijing Road, Shanghai 200040, China.
Wen
W
Jiang
China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 200120, China.
Jianli
J
Chen
China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 200120, China. Electronic address: sipiluwg@163.com.
Weigeng
W
Lu
China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 200120, China. Electronic address: gao.qi@sipi.com.cn.
Qi
Q
Gao
D047309:Flavones / Q000138:chemical synthesis* / Q000737:chemistry; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D030441:Saussurea / Q000737:chemistry*
D047309:Flavones; C023717:acacetin
Acacetin; Atrial fibrillation; Catalysis; Flavones; Fries rearrangement; Synthesis