Retinal Detachment After Subretinal Stem Cell Transplantation.
A 60-year-old man with Stargardt's macular dystrophy and visual acuity of 20/400 in the right eye and 20/60 in the left eye underwent a subretinal injection of autologous bone marrow-derived stem cells in the right eye. The patient developed a retinal detachment in the right eye 2 months later that was initially treated with a scleral buckle, but the patient subsequently developed a recurrent retinal detachment with proliferative vitreoretinopathy. A pars plana vitrectomy, membrane peel, fluid-air exchange, endolaser, and silicone oil injection were then performed. The retina remained attached 5 months later, with improvement in visual acuity from hand motions to 20/300 post-vitrectomy. Retinal detachment may occur after subretinal injection of stem cells. Proliferative vitreoretinopathy may develop in these patients, but the visual acuity may return to baseline after retinal reattachment. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:600-601.].
Ella H
EH
Leung
Harry W
HW
Flynn
Thomas A
TA
Albini
Carlos A
CA
Medina
D006801:Humans; D008268:Macular Degeneration / Q000151:congenital* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012160:Retina; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D012591:Scleral Buckling / Q000379:methods; D000080362:Stargardt Disease; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014182:Transplantation, Autologous