Using Electron Paramagnetic Resonance Spectroscopy To Facilitate Problem Solving in Pharmaceutical Research and Development.
As new chemical methodologies driven by single-electron chemistry emerge, process and analytical chemists must develop approaches to rapidly solve problems in this nontraditional arena. Electron paramagnetic resonance spectroscopy has been long known as a preferred technique for the study of paramagnetic species. However, it is only recently finding application in contemporary pharmaceutical development, both to study reactions and to track the presence of undesired impurities. Several case studies are presented here to illustrate its utility in modern pharmaceutical development efforts.
Department of Process & Analytical Chemistry, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Ian
I
Mangion
Department of Process & Analytical Chemistry, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Yizhou
Y
Liu
Department of Process & Analytical Chemistry, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Mikhail
M
Reibarkh
Department of Process & Analytical Chemistry, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
R Thomas
RT
Williamson
Department of Process & Analytical Chemistry, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
Christopher J
CJ
Welch
D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D055808:Drug Discovery; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D000071220:Pharmaceutical Research; D011340:Problem Solving
D056831:Coordination Complexes