[Significance of detection of biomarker fecal bile acids in the diagnosis and treatment of childhood Henoch-Schönlein purpura].
OBJECTIVE
To investigate the changes and clinical significance of biomarker fecal bile acids (BA) in children with Henoch-Schönlein purpura (HSP).


METHODS
Nineteen children with HSP and twenty-seven healthy children were enrolled in this study. The stool samples were obtained at the acute and remission phases. Fecal BA levels were measured by high performance liquid chromatography mass spectrometry (HPLC-MS).


RESULTS
The fecal cholic acid level in the HSP remission group was significantly higher than in the HSP acute group and the healthy control group (P<0.016). The fecal chenodeoxycholic acid level in the HSP remission group was significantly higher than in the healthy control group (P<0.016). The levels of fecal secondary colonic bile acids, deoxycholic acid and lithocholic acid, in the HSP acute and remission groups were significantly lower than in the healthy control group(P<0.05, P<0.016 respectively). No significant differences were found in the levels of fecal urosodeoxycholic acid among the three groups (P>0.05).


CONCLUSIONS
Fecal secondary colonic bile acids, deoxycholic acid and lithocholic acid, are in decrease in children with HSP at the acute stage, which may be involved in the pathogenesis and treatment outcomes of HSP.
Department of Pediatrics, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China. 13577097854@163.com.
Hong-Wei
HW
Hu
Jiang
J
Duan
Bo
B
Zhao
Jing-Jing
JJ
Xiong
Mei
M
Liu
Jing-Jing
JJ
Cui
Xiao-Fei
XF
Ji
Ting-Ting
TT
Zhang
Li-Zhi
LZ
Zhang
Yong-Kun
YK
Huang
D001647:Bile Acids and Salts / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D002648:Child; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000175:diagnosis* / Q000628:therapy; D008297:Male
D001647:Bile Acids and Salts; D015415:Biomarkers