Biodistribution in rats and estimates of doses to humans from (64)CuCl2, a potential theranostic tracer.
The aim of this study was to obtain data on the biodistribution of (64)CuCl2 in rats and to obtain estimates of the radiation doses to humans by extrapolating the animal data. MicroPET imaging and biodistribution studies were carried out with Wistar rats, and the doses were estimated with OLINDA/EXM. The lower large intestine wall was found to be the critical organ with an absorbed dose of 139±34 and 125±32µGy/MBq for females and males, respectively. The corresponding effective doses were estimated as 47±4 and 39±4µSv/MBq.
Unidad Radiofarmacia-Ciclotrón, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F. C.P. 04510, Mexico; Facultad de Ciencias, Universidad Autónoma del Estado de México, Toluca, Edo de México C.P. 50000, Mexico.
Juan C
JC
Manrique-Arias
Unidad Radiofarmacia-Ciclotrón, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F. C.P. 04510, Mexico.
Jhonatan
J
Carrasco-Hernández
Facultad de Ciencias, Universidad Autónoma del Estado de México, Toluca, Edo de México C.P. 50000, Mexico.
Pedro G
PG
Reyes
Unidad Radiofarmacia-Ciclotrón, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F. C.P. 04510, Mexico. Electronic address: avilarod@uwalumni.com.
Miguel A
MA
Ávila-Rodríguez
D000818:Animals; D003300:Copper / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D011874:Radiometry; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D000068936:Theranostic Nanomedicine; D014018:Tissue Distribution
D019275:Radiopharmaceuticals; D003300:Copper; C029892:cupric chloride
Biodistribution; Copper chloride; Copper-64; Internal dosimetry; Pet; Theranostics