Novel catalase loaded nanocores for the treatment of inflammatory bowel diseases.
Inflammatory bowel disease (IBD) is an inflammatory disorder of the digestive tract reported to be primarily caused by oxidative stress. In this study, alginate encapsulated nanoceramic carriers were designed to deliver acid labile antioxidant enzyme catalase orally. Complete system was characterized for size, loading efficiency, in vitro antioxidant assay and in vitro release. The prepared nanoceramic system was found to be spherical with diameter of 925 ± 6.81 nm. The in vitro release data followed the Higuchi model in acidic buffer whereas in alkaline pH sustained and almost first order release of enzyme was observed up to 6 h.
a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur , India.
Arun K S
AKS
Parihar
a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur , India.
Shikha
S
Srivastava
a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur , India.
Satish
S
Patel
a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur , India.
Manju R
MR
Singh
a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur , India.
Deependra
D
Singh
D055162:Biocatalysis; D001682:Biological Availability; D002374:Catalase / Q000737:chemistry* / Q000378:metabolism / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002516:Ceramics / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004795:Enzyme Stability; D006863:Hydrogen-Ion Concentration; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D049329:Nanostructures / Q000737:chemistry*; D011487:Protein Conformation
D004337:Drug Carriers; D002374:Catalase
Antioxidant enzymes; IBD; catalase; hydroxyapatite; nanoceramic core