3D Printed Modeling of the Mitral Valve for Catheter-Based Structural Interventions.
As catheter-based structural heart interventions become increasingly complex, the ability to effectively model patient-specific valve geometry as well as the potential interaction of an implanted device within that geometry will become increasingly important. Our aim with this investigation was to combine the technologies of high-spatial resolution cardiac imaging, image processing software, and fused multi-material 3D printing, to demonstrate that patient-specific models of the mitral valve apparatus could be created to facilitate functional evaluation of novel trans-catheter mitral valve repair strategies. Clinical 3D transesophageal echocardiography and computed tomography images were acquired for three patients being evaluated for a catheter-based mitral valve repair. Target anatomies were identified, segmented and reconstructed into 3D patient-specific digital models. For each patient, the mitral valve apparatus was digitally reconstructed from a single or fused imaging data set. Using multi-material 3D printing methods, patient-specific anatomic replicas of the mitral valve were created. 3D print materials were selected based on the mechanical testing of elastomeric TangoPlus materials (Stratasys, Eden Prairie, Minnesota, USA) and were compared to freshly harvested porcine leaflet tissue. The effective bending modulus of healthy porcine MV tissue was significantly less than the bending modulus of TangoPlus (p < 0.01). All TangoPlus varieties were less stiff than the maximum tensile elastic modulus of mitral valve tissue (3697.2 ± 385.8 kPa anterior leaflet; 2582.1 ± 374.2 kPa posterior leaflet) (p < 0.01). However, the slopes of the stress-strain toe regions of the mitral valve tissues (532.8 ± 281.9 kPa anterior leaflet; 389.0 ± 156.9 kPa posterior leaflet) were not different than those of the Shore 27, Shore 35, and Shore 27 with Shore 35 blend TangoPlus material (p > 0.95). We have demonstrated that patient-specific mitral valve models can be reconstructed from multi-modality imaging datasets and fabricated using the multi-material 3D printing technology and we provide two examples to show how catheter-based repair devices could be evaluated within specific patient 3D printed valve geometry. However, we recognize that the use of 3D printed models for the development of new therapies, or for specific procedural training has yet to be defined.
Department of Cardiology, Houston Methodist Research Institute, Weill Cornell Medicine/Houston Methodist Hospital, 6550 Fannin Street, SM-677, Houston, TX, 77030, USA.
Marija
M
Vukicevic
Department of Bioengineering, Rice University, 6100 Main St., MS 142, Houston, TX, 77005, USA.
Daniel S
DS
Puperi
Department of Bioengineering, Rice University, 6100 Main St., MS 142, Houston, TX, 77005, USA.
K
K
Jane Grande-Allen
Department of Cardiology, Houston Methodist Research Institute, Weill Cornell Medicine/Houston Methodist Hospital, 6550 Fannin Street, SM-677, Houston, TX, 77030, USA. shlittle@tmhs.org.
Stephen H
SH
Little
D000818:Animals; D006328:Cardiac Catheterization / Q000295:instrumentation / Q000379:methods; D017548:Echocardiography, Transesophageal; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D066330:Printing, Three-Dimensional; D013552:Swine; D014057:Tomography, X-Ray Computed
3D printing; Heart valve modeling; MitraClip; Percutaneous mitral valve repair