Combination of Two Marek's Disease Virus Vectors Shows Effective Vaccination Against Marek's Disease, Infectious Bursal Disease, and Newcastle Disease.
Herpesvirus of turkeys (HVT) is a widely used vector for poultry vaccines. However, different HVTs expressing different foreign antigens cannot always be used simultaneously because of the risk of recombination and interference. In this study, we inoculated a mixture of an HVT-expressing the antigen of Newcastle disease virus (NDV; HVT/ND) and Marek's disease virus (MDV) serotype 1 Rispens virus expressing the antigen of infectious bursal disease virus (IBD; Ripens/IBD) into chickens. This mixture showed 94%, 100%, or 94% protection against MDV, IBDV, or NDV challenge, respectively. In conclusion, the combination of Rispens/IBD and HVT/ND is effective for vaccination against MDV, IBDV, and NDV without significant interference.
Ceva Animal Health (Japan Campus), 1-6 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045 Japan.
Yukari
Y
Ishihara
Ceva Animal Health (Japan Campus), 1-6 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045 Japan.
Motoyuki
M
Esaki
Ceva Animal Health (Japan Campus), 1-6 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045 Japan.
Shuji
S
Saitoh
Ceva Animal Health (Japan Campus), 1-6 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045 Japan.
Atsushi
A
Yasuda
D000818:Animals; D018175:Birnaviridae Infections / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D002645:Chickens; D026002:Herpesvirus 1, Meleagrid / Q000276:immunology; D007243:Infectious bursal disease virus / Q000276:immunology; D008380:Marek Disease / Q000517:prevention & control*; D022501:Marek Disease Vaccines / Q000276:immunology*; D009521:Newcastle Disease / Q000517:prevention & control* / Q000821:virology; D009522:Newcastle disease virus / Q000276:immunology; D011201:Poultry Diseases / Q000517:prevention & control* / Q000821:virology; D014611:Vaccination / Q000662:veterinary*
D022501:Marek Disease Vaccines
Marek's disease virus; Newcastle disease virus; covaccination; infectious bursal disease virus; interference; poultry vaccine; recombination