Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets.
Neuroscience Research, AbbVie, 6706 Ludwigshafen, Germany. Present address: Partnership for Assessment and Accreditation of Scientific Practice, Am Aukopf 14/1, D-69118 Heidelberg, Germany and Institute of Pharmacology, Pavlov Medical University, 197022 St Petersburg, Russia.
Anton
A
Bespalov
Janssen Research and Development, B-2340 Beerse, Belgium.
Thomas
T
Steckler
Global Policy and International Public Affairs, Pfizer, New York, 10017 New York, USA.
Bruce
B
Altevogt
National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland 20892, USA.
Elena
E
Koustova
National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland 20892, USA.
Phil
P
Skolnick
Non-Clinical Research and Development, Alkermes, Waltham, Massachusetts 02451, USA.
Daniel
D
Deaver
Institut de Recherche Servier, 78290 Croissy sur Seine, France.
Mark J
MJ
Millan
Neuroscience Research, H. Lundbeck A/S, Copenhagen, 2500 Valby, Denmark.
Jesper F
JF
Bastlund
Discovery Chemistry &DMPK; Lundbeck Research USA, Paramus, New Jersey 07652, USA. Present address: Concert Pharmaceuticals, Inc., 99 Hayden Avenue, Lexington, Massachusetts 02421, USA.
Dario
D
Doller
Neuroscience Discovery Research, Lilly Research Labs, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
Jeffrey
J
Witkin
Pierre Fabre Research Institute, 81106 Castres, France. Present address: BIAL-Portela &Ca S.A., Avenida da Siderurgia Nacional, 4745-457 São Mamede do Coronado, Portugal.
Paul
P
Moser
Neuroscience and Pain Research Unit, Pfizer, Cambridge, Massachusetts 02139, USA.
Patricio
P
O'Donnell
Boehringer Ingelheim Pharma, 55218 Ingelheim am Rhein, Germany.
Ulrich
U
Ebert
University of California San Diego, La Jolla, California 92093, USA.
Mark A
MA
Geyer
Roche Pharma Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Roche Innovation Center Basel, CH-4070 Basel, Switzerland.
Eric
E
Prinssen
Roche Pharma Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Roche Innovation Center Basel, CH-4070 Basel, Switzerland.
Theresa
T
Ballard
Edinburgh University, Old College, South Bridge, Edinburgh EH8 9YL, UK.
Malcolm
M
Macleod
D000818:Animals; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D002986:Clinical Trials as Topic / Q000592:standards*; D004353:Drug Evaluation, Preclinical / Q000592:standards*; D006801:Humans; D012107:Research Design; D017211:Treatment Failure