Kallistatin levels in HIV-infected patients and effects of statin therapy.
BACKGROUND
Kallistatin, a serine proteinase inhibitor, has vasodilatory and anti-inflammatory properties and is increased in other inflammatory conditions. We measured kallistatin in HIV for the first time, examined its relationship with inflammation, and determined if statin therapy affected levels.


METHODS
Kallistatin levels were measured in subjects from a randomized, double-blinded, placebo-controlled trial.


RESULTS
One hundred and thirty-five HIV-infected subjects were included. Kallistatin levels were 28.4 μg/mL at baseline and not affected by rosuvastatin. Levels were correlated with high-sensitivity C-reactive protein (hsCRP), interleukin-6, fibrinogen and insulin resistance.


CONCLUSIONS
Kallistatin levels were correlated with some markers of systemic inflammation and should be further explored in the HIV population.
a Department of Medicine, Division of Pediatric Infectious Diseases, Emory University School of Medicine , Atlanta , GA , USA.|b Departments of Medicine and Pediatrics, Divisions of Infectious Diseases, Medical University of South Carolina , Charleston , SC , USA.
Allison Ross
AR
Eckard
a Department of Medicine, Division of Pediatric Infectious Diseases, Emory University School of Medicine , Atlanta , GA , USA.
Soohee
S
Cho
c Departments of Medicine and Pediatrics, Divisions of Infectious Diseases, Case Western Reserve University and University Hospitals Case Medical Center , Cleveland , OH , USA.
Mary Ann
MA
O'Riordan
c Departments of Medicine and Pediatrics, Divisions of Infectious Diseases, Case Western Reserve University and University Hospitals Case Medical Center , Cleveland , OH , USA.
Grace A
GA
McComsey
D015415:Biomarkers / Q000097:blood; D004311:Double-Blind Method; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007249:Inflammation / Q000097:blood; D000068718:Rosuvastatin Calcium / Q000627:therapeutic use; D015842:Serine Proteinase Inhibitors / Q000097:blood; D015843:Serpins / Q000097:blood*
D015415:Biomarkers; D015842:Serine Proteinase Inhibitors; D015843:Serpins; C051324:kallistatin; D000068718:Rosuvastatin Calcium
Cardiovascular disease; HIV; carotid intima-media thickness; coagulation; immune activation; inflammation; kallistatin