PRKCE gene encoding protein kinase C-epsilon-Dual roles at sarcomeres and mitochondria in cardiomyocytes.
Protein kinase C-epsilon (PKCε) is an isoform of a large PKC family of enzymes that has a variety of functions in different cell types. Here we discuss two major roles of PKCε in cardiac muscle cells; specifically, its role in regulating cardiac muscle contraction via targeting the sarcomeric proteins, as well as modulating cardiac cell energy production and metabolism by targeting cardiac mitochondria. The importance of PKCε action is described within the context of intracellular localization, as substrate selectivity and specificity is achieved through spatiotemporal targeting of PKCε. Accordingly, the role of PKCε in regulating myocardial function in physiological and pathological states has been documented in both cardioprotection and cardiac hypertrophy.
Departments of Physiology, Medicine (Cardiology) and Bioinformatics, NIH BD2K Center of Excellence for Biomedical Computing, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: sarahbscruggs@gmail.com.
Sarah B
SB
Scruggs
Departments of Physiology, Medicine (Cardiology) and Bioinformatics, NIH BD2K Center of Excellence for Biomedical Computing, University of California Los Angeles, Los Angeles, CA 90095, USA.
Ding
D
Wang
Departments of Physiology, Medicine (Cardiology) and Bioinformatics, NIH BD2K Center of Excellence for Biomedical Computing, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: peipeiping@earthlink.net.
Peipei
P
Ping
D016718:Arachidonic Acid / Q000494:pharmacology; D006332:Cardiomegaly / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D002316:Cardiotonic Agents / Q000494:pharmacology; D004789:Enzyme Activation; D015870:Gene Expression; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008929:Mitochondria, Heart / Q000187:drug effects / Q000201:enzymology*; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D010656:Phenylephrine / Q000494:pharmacology; D051744:Protein Kinase C-epsilon / Q000235:genetics* / Q000378:metabolism; D012518:Sarcomeres / Q000187:drug effects / Q000201:enzymology*; D013379:Substrate Specificity
D002316:Cardiotonic Agents; D009124:Muscle Proteins; D010656:Phenylephrine; D016718:Arachidonic Acid; C497255:PRKCE protein, human; D051744:Protein Kinase C-epsilon; D007545:Isoproterenol
Cardiac hypertrophy; Cardioprotection; Drug target; Myocardial function; Phosphorylation; Substrates