[The Molecular Aspect of the Antitumor Effect of Oxaliplatin in Combination with 5-FU].
Platinum-based chemotherapeutic drugs as a component of combination chemotherapy are widely used in the treatment of cancer. In particular, oxaliplatin(L-OHP), one such platinum-based chemotherapeutic drug, has a synergistic effect in combination with 5-FU and Leucovorin for the treatment of advanced colorectal cancer. However, the underlying molecular mechanism of this synergistic effect has not been fully clarified yet. In this review, we summarize several updates about the in vitro action of oxaliplatin in human tumor cells and discuss the underlying mechanism of its synergistic effect with 5-FU.
Dept. of Molecular Oncology, Graduate School of Medical Sciences, Kyushu University.
Hiroyuki
H
Kitao
Shinichi
S
Kiyonari
Makoto
M
Iimori
Shinichiro
S
Niimi
Yuki
Y
Kataoka
Shingo
S
Akiyama
Keitaro
K
Edahiro
Ryota
R
Nakanishi
Eriko
E
Tokunaga
Hiroshi
H
Saeki
Eiji
E
Oki
Shingo
S
Kanaji
Yoshihiro
Y
Kakeji
Yoshihiko
Y
Maehara
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D005472:Fluorouracil / Q000008:administration & dosage; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000737:chemistry; D000077150:Oxaliplatin; D011755:Pyrophosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D009944:Organoplatinum Compounds; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D000077150:Oxaliplatin; D011755:Pyrophosphatases; C020020:dUTP pyrophosphatase; D005472:Fluorouracil