Posttranslational control of HuR function.
The RNA-binding protein HuR (human antigen R) associates with numerous transcripts, coding and noncoding, and controls their splicing, localization, stability, and translation. Through its regulation of target transcripts, HuR has been implicated in cellular events including proliferation, senescence, differentiation, apoptosis, and the stress and immune responses. In turn, HuR influences processes such as cancer and inflammation. HuR function is primarily regulated through posttranslational modifications that alter its subcellular localization and its ability to bind target RNAs; such modifications include phosphorylation, methylation, ubiquitination, NEDDylation, and proteolytic cleavage. In this review, we describe the modifications that impact upon HuR function on gene expression programs and disease states. WIREs RNA 2017, 8:e1372. doi: 10.1002/wrna.1372 For further resources related to this article, please visit the WIREs website.
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Ioannis
I
Grammatikakis
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Kotb
K
Abdelmohsen
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Myriam
M
Gorospe
D000818:Animals; D000067780:ELAV-Like Protein 1 / Q000235:genetics* / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D011499:Protein Processing, Post-Translational / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*
D000067780:ELAV-Like Protein 1; D012333:RNA, Messenger