Acrokeratosis Paraneoplastica with Adenocarcinoma of the Colon Treated with Topical Tretinoin.
Acrokeratosis paraneoplastica, or Bazex syndrome, is one of the paraneoplastic syndromes. The characteristic skin lesions include palmoplantar keratoderma, psoriasiform skin lesions, hyperpigmentation, and nail dystrophy. The most common associated neoplasms are squamous cell carcinoma of the upper respiratory tract and other kinds of tumors with cervical lymph node metastasis. A 63-year-old woman presented with an 11 month history of hyperkeratotic lesions on the palms and soles. Ten months before she had been diagnosed with adenocarcinoma of the colon and undergone a left hemicolectomy. We report a case of acrokeratosis paraneoplastica associated with colon cancer which persisted after removal of the primary cancer, but resolved with topical tretinoin treatment.
Department of Dermatology, Gachon University of Medicine and Science, Incheon, Korea.
Jin Ok
JO
Baek
Department of Dermatology, Gachon University of Medicine and Science, Incheon, Korea.
Hye Young
HY
Lee
Department of Dermatology, Gachon University of Medicine and Science, Incheon, Korea.
Jong Rok
JR
Lee
Department of Dermatology, Gachon University of Medicine and Science, Incheon, Korea.
Joo Young
0000-0002-9878-6691
JY
Roh
Acrokeratosis paraneoplastica; Bazex syndrome; Colon cancer; Tretinoin