Type I collagen fibrils and discoidin domain receptor 1 set invadosomes straight.
Accumulation of type I collagen fibrils in tumors is associated with an increased risk of metastasis. We recently demonstrated that the collagen sensor discoidin domain receptor 1 (DDR1) interacts with type I collagen fibrils to allow proteolysis-based cancer cell invasion through the formation of a new class of invadosomes, termed linear invadosomes.
Institut National de la Santé et de la Recherche Médicale; U1053; Bordeaux, France; Université de Bordeaux; Bordeaux, France.
Violaine
V
Moreau
Institut National de la Santé et de la Recherche Médicale; U1053; Bordeaux, France; Université de Bordeaux; Bordeaux, France.
Frédéric
F
Saltel
DDR1; invadopodia; invadosomes; type I collagen