Treatment outcome of radiation therapy and concurrent targeted molecular therapy in spinal metastasis from renal cell carcinoma.
OBJECTIVE
To evaluate the clinical outcomes of patients who underwent radiation therapy with or without targeted molecular therapy for the treatment of spinal metastasis from renal cell carcinoma (RCC).


METHODS
A total of 28 spinal metastatic lesions from RCC patients treated with radiotherapy between June 2009 and June 2015 were retrospectively reviewed. Thirteen lesions were treated concurrently with targeted molecular therapy (concurrent group) and 15 lesions were not (nonconcurrent group). Local control was defined as lack of radiographically evident local progression and neurological deterioration.


RESULTS
At a median follow-up of 11 months (range, 2 to 58 months), the 1-year local progression-free rate (LPFR) was 67.0%. The patients with concurrent targeted molecular therapy showed significantly higher LPFR than those without (p = 0.019). After multivariate analysis, use of concurrent targeted molecular therapy showed a tendency towards improved LPFR (hazard ratio, 0.13; 95% confidence interval, 0.01 to 1.16). There was no difference in the incidence of systemic progression between concurrent and nonconcurrent groups. No grade ≥2 toxicities were observed during or after radiotherapy.


CONCLUSIONS
Our study suggests the possibility that concurrent use of targeted molecular therapy during radiotherapy may improve LPFR. Further study with a large population is required to confirm these results.
Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.
Sangjoon
S
Park
Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.
Kyung Hwan
KH
Kim
Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.
Woo Joong
WJ
Rhee
Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.
Jeongshim
J
Lee
Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.
Yeona
Y
Cho
Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.
Woong Sub
WS
Koom
Molecular targeted therapy; Neoplasm metastasis; Radiotherapy; Renal cell carcinoma