The association of alcohol consumption with patient survival after organophosphate poisoning: a multicenter retrospective study.
Organophosphate (OP) intoxication remains a serious worldwide health concern, and many patients with acute OP intoxication have also consumed alcohol. Therefore, we evaluated the association of blood alcohol concentration (BAC) with mortality among patients with OP intoxication. We retrospectively reviewed records from 135 patients who were admitted to an emergency department (ED) for OP intoxication between January 2000 and December 2012. Factors that were associated with patient survival were identified via receiver operating characteristic curve, multiple logistic regression, and Kaplan-Meier survival analyses. Among 135 patients with acute OP poisoning, 112 patients survived (overall mortality rate: 17 %). The non-survivors also exhibited a significantly higher BAC, compared to the survivors [non-survivors: 192 mg/dL, interquartile range (IQR) 97-263 mg/dL vs. survivors: 80 mg/dL, IQR 0-166.75 mg/dL; p < 0.001]. A BAC cut-off value of 173 mg/dL provided an area under the curve of 0.744 [95 % confidence interval (CI) 0.661-0.815], a sensitivity of 65.2 %, and a specificity of 81.2 %. A BAC of >173 mg/dL was associated with a significantly increased risk of 6-month mortality in the multiple logistic regression model (odds ratio 4.92, 95 % CI 1.45-16.67, p = 0.001). The Cox proportional hazard model revealed that a BAC of >173 mg/dL provided a hazard ratio of 3.07 (95 % CI 1.19-7.96, p = 0.021). A BAC of >173 mg/dL is a risk factor for mortality among patients with OP intoxication.
Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University, 431-070, 896 Pyeongchon-dong, Dongan-gu, Anyang-Si, Gyeonggi-do, South Korea.|Department of Emergency Medicine, Graduate School of Medicine, Kangwon National University, Chuncheon, Kangwon-Do, 200-701, South Korea.
Young Hwan
YH
Lee
Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University, 431-070, 896 Pyeongchon-dong, Dongan-gu, Anyang-Si, Gyeonggi-do, South Korea.|Department of Emergency Medicine, Graduate School of Medicine, Kangwon National University, Chuncheon, Kangwon-Do, 200-701, South Korea.
Young Taeck
YT
Oh
Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University, 431-070, 896 Pyeongchon-dong, Dongan-gu, Anyang-Si, Gyeonggi-do, South Korea.
Won Woong
WW
Lee
Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University, 431-070, 896 Pyeongchon-dong, Dongan-gu, Anyang-Si, Gyeonggi-do, South Korea.
Hee Cheol
HC
Ahn
Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University, 431-070, 896 Pyeongchon-dong, Dongan-gu, Anyang-Si, Gyeonggi-do, South Korea.
You Dong
YD
Sohn
Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University, 431-070, 896 Pyeongchon-dong, Dongan-gu, Anyang-Si, Gyeonggi-do, South Korea.
Ji Yun
JY
Ahn
Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University, 431-070, 896 Pyeongchon-dong, Dongan-gu, Anyang-Si, Gyeonggi-do, South Korea.
Yong Hun
YH
Min
Department of Emergency Medicine, Wonju College of Medicine, Yonsei University, Wonju, South Korea.
Hyun
H
Kim
Hwacheon Health Center and Country Hospital, Hwacheon, South Korea.
Seung Wook
SW
Lim
Emergency Medicine, Graduate School of Hallym University, Chuncheon, South Korea.|Department of Emergency Medical Technology, Seojeong College, Yangju, South Korea.
Kui Ja
KJ
Lee
Department of Emergency Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Dong Hyuk
DH
Shin
Department of Emergency Medicine, School of Medicine, Konkuk University Medical Center, Konkuk University, Seoul, South Korea.
Sang O
SO
Park
Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University, 431-070, 896 Pyeongchon-dong, Dongan-gu, Anyang-Si, Gyeonggi-do, South Korea. aukawa1@naver.com.
Seung Min
SM
Park
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000453:epidemiology; D000067401:Blood Alcohol Content; D002802:Cholinesterases / Q000032:analysis / Q000097:blood; D015331:Cohort Studies; D004636:Emergency Service, Hospital / Q000458:organization & administration / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D062025:Organophosphate Poisoning / Q000453:epidemiology / Q000401:mortality*; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016019:Survival Analysis
D000067401:Blood Alcohol Content; D002802:Cholinesterases
Alcohol; Mortality; Organophosphate; Poisoning; Pseudocholinesterase