Role of Telomerase in the Cardiovascular System.
Aging is one major risk factor for the incidence of cardiovascular diseases and the development of atherosclerosis. One important enzyme known to be involved in aging processes is Telomerase Reverse Transcriptase (TERT). After the discovery of the enzyme in humans, TERT had initially only been attributed to germ line cells, stem cells and cancer cells. However, over the last few years it has become clear that TERT is also active in cells of the cardiovascular system including cardiac myocytes, endothelial cells, smooth muscle cells and fibroblasts. Interference with the activity of this enzyme greatly contributes to cardiovascular diseases. This review will summarize the findings on the role of TERT in cardiovascular cells. Moreover, recent findings concerning TERT in different mouse models with respect to cardiovascular diseases will be described. Finally, the extranuclear functions of TERT will be covered within this review.
IUF-Leibniz Research Institute for Environmental Medicine, 40225 Duesseldorf, Germany. mark.zurek@uni-duesseldorf.de.
Mark
M
Zurek
IUF-Leibniz Research Institute for Environmental Medicine, 40225 Duesseldorf, Germany. joachim.altschmied@uni-duesseldorf.de.
Joachim
J
Altschmied
IUF-Leibniz Research Institute for Environmental Medicine, 40225 Duesseldorf, Germany. stefanie@gonnissen.de.
Stefanie
S
Kohlgrüber
IUF-Leibniz Research Institute for Environmental Medicine, 40225 Duesseldorf, Germany. niloofar.ale-agha@uni-duesseldorf.de.
Niloofar
N
Ale-Agha
IUF-Leibniz Research Institute for Environmental Medicine, 40225 Duesseldorf, Germany. juhae001@uni-duesseldorf.de.|Central Institute of Clinical Chemistry and Laboratory Medicine, Medical Faculty, University of Duesseldorf, 40225 Duesseldorf, Germany. juhae001@uni-duesseldorf.de.
Judith
J
Haendeler
Telomerase Reverse Transcriptase; aging; cardiovascular cells