Autophagy in kidney disease and aging: lessons from rodent models.
Autophagy is a highly regulated lysosomal protein degradation pathway that removes protein aggregates and damaged or excess organelles to maintain intracellular homeostasis and cell integrity. Dysregulation of autophagy is involved in the pathogenesis of a variety of metabolic and age-related diseases. Growing evidence suggests that autophagy is implicated in cell injury during renal diseases, both in the tubulointerstitial compartment and in glomeruli. Nevertheless, the impact of autophagy on renal disease progression and aging is still not fully understood. This review summarizes the recent advances in understanding the role of autophagy for kidney disease and aging.
Paris Cardiovascular Research Centre-PARCC, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Olivia
O
Lenoir
Paris Cardiovascular Research Centre-PARCC, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Nephrology Division, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; FRIAS, Freiburg Institute for Advanced Studies and Center for Biological System Analysis-ZBSA, Freiburg, Germany. Electronic address: pierre-louis.tharaux@inserm.fr.
Pierre-Louis
PL
Tharaux
FRIAS, Freiburg Institute for Advanced Studies and Center for Biological System Analysis-ZBSA, Freiburg, Germany; Department of Medicine IV, Faculty of Medicine, University of Freiburg, Germany; BIOSS Center for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, Freiburg, Germany; Center for Systems Biology (ZBSA), Albert-Ludwigs-University, Freiburg, Germany. Electronic address: tobias.huber@uniklinik-freiburg.de.
Tobias B
TB
Huber
D000375:Aging / Q000502:physiology*; D000818:Animals; D001343:Autophagy; D007674:Kidney Diseases / Q000503:physiopathology*
acute kidney injury; aging; autophagy; endothelium; glomerulus; kidney; kidney transplantation; mTOR; podocyte; polycystic kidney disease