A smart multifunctional drug delivery nanoplatform for targeting cancer cells.
Wirelessly guided magnetic nanomachines are promising vectors for targeted drug delivery, which have the potential to minimize the interaction between anticancer agents and healthy tissues. In this work, we propose a smart multifunctional drug delivery nanomachine for targeted drug delivery that incorporates a stimuli-responsive building block. The nanomachine consists of a magnetic nickel (Ni) nanotube that contains a pH-responsive chitosan hydrogel in its inner cavity. The chitosan inside the nanotube serves as a matrix that can selectively release drugs in acidic environments, such as the extracellular space of most tumors. Approximately a 2.5 times higher drug release from Ni nanotubes at pH = 6 is achieved compared to that at pH = 7.4. The outside of the Ni tube is coated with gold. A fluorescein isothiocyanate (FITC) labeled thiol-ssDNA, a biological marker, was conjugated on its surface by thiol-gold click chemistry, which enables traceability. The Ni nanotube allows the propulsion of the device by means of external magnetic fields. As the proposed nanoarchitecture integrates different functional building blocks, our drug delivery nanoplatform can be employed for carrying molecular drug conjugates and for performing targeted combinatorial therapies, which can provide an alternative and supplementary solution to current drug delivery technologies.
Institute of Robotics and Intelligent Systems (IRIS), ETH Zurich, Tannenstrasse 3, CH-8092 Zurich, Switzerland. vidalp@ethz.ch chenxian@ethz.ch.
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D000970:Antineoplastic Agents / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D048271:Chitosan; D016503:Drug Delivery Systems; D065546:Drug Liberation; D019793:Fluorescein; D006046:Gold; D006801:Humans; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D017879:Isothiocyanates; D053768:Metal Nanoparticles; D009369:Neoplasms / Q000188:drug therapy; D009532:Nickel
D000970:Antineoplastic Agents; D020100:Hydrogels; D017879:Isothiocyanates; D006046:Gold; D009532:Nickel; D048271:Chitosan; D019793:Fluorescein