Resveratrol attenuates peripheral and brain inflammation and reduces ischemic brain injury in aged female mice.
Resveratrol is known to improve metabolic dysfunction associated with obesity. Visceral obesity is a sign of aging and is considered a risk factor for ischemic stroke. In this study, we investigated the effects of resveratrol on inflammation in visceral adipose tissue and the brain and its effects on ischemic brain injury in aged female mice. Mice treated with resveratrol (0.1 mg/kg, p.o.) for 10 days showed reduced levels of interleukin-1β and tumor necrosis factor-α, as well as a reduction in the size of adipocytes in visceral adipose tissue. Resveratrol also reduced interleukin-1β and tumor necrosis factor-α protein levels and immunoglobulin G extravasation in the brain. Mice treated with resveratrol demonstrated smaller infarct size, improved neurological function, and blunted peripheral inflammation at 3 days postischemic stroke. These results showed that resveratrol counteracted inflammation in visceral adipose tissue and in the brain and reduced stroke-induced brain injury and peripheral inflammation in aged female mice. Therefore, resveratrol administration can be a valuable strategy for the prevention of age-associated and disease-provoked inflammation in postmenopausal women.
Department of Pharmacology, School of Medicine, Ewha Womans University, Seoul, Republic of Korea; Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
Sae Im
SI
Jeong
Department of Pharmacology, School of Medicine, Ewha Womans University, Seoul, Republic of Korea; Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
Jin A
JA
Shin
Department of Neurology/Neuroscience, Brain & Mind Research Institute, Weill Cornell Medical College at Burke Medical Research Institute, White Plains, NY, USA.
Sunghee
S
Cho
Department of Pharmacology, School of Medicine, Ewha Womans University, Seoul, Republic of Korea; Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
Hye Won
HW
Kim
School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
Ji Yoon
JY
Lee
Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, Republic of Korea; Department of Physiology, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
Jihee Lee
JL
Kang
Department of Pharmacology, School of Medicine, Ewha Womans University, Seoul, Republic of Korea; Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, Republic of Korea. Electronic address: empark@ewha.ac.kr.
Eun-Mi
EM
Park
D017667:Adipocytes / Q000473:pathology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000517:prevention & control*; D004660:Encephalitis / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007249:Inflammation / Q000517:prevention & control*; D053583:Interleukin-1beta / Q000378:metabolism; D050152:Intra-Abdominal Fat / Q000166:cytology / Q000378:metabolism; D008810:Mice, Inbred C57BL; D017698:Postmenopause; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage*; D020521:Stroke / Q000517:prevention & control*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D007074:Immunoglobulin G; D053583:Interleukin-1beta; D013267:Stilbenes; D014409:Tumor Necrosis Factor-alpha; D000077185:Resveratrol
Aging; Females; Inflammation; Ischemic stroke; Resveratrol; Visceral adipose tissue