Towards a Standard Psychometric Diagnostic Interview for Subjects at Ultra High Risk of Psychosis: CAARMS versus SIPS.
Background. Several psychometric instruments are available for the diagnostic interview of subjects at ultra high risk (UHR) of psychosis. Their diagnostic comparability is unknown. Methods. All referrals to the OASIS (London) or CAMEO (Cambridgeshire) UHR services from May 13 to Dec 14 were interviewed for a UHR state using both the CAARMS 12/2006 and the SIPS 5.0. Percent overall agreement, kappa, the McNemar-Bowker χ (2) test, equipercentile methods, and residual analyses were used to investigate diagnostic outcomes and symptoms severity or frequency. A conversion algorithm (CONVERT) was validated in an independent UHR sample from the Seoul Youth Clinic (Seoul). Results. There was overall substantial CAARMS-versus-SIPS agreement in the identification of UHR subjects (n = 212, percent overall agreement = 86%; kappa = 0.781, 95% CI from 0.684 to 0.878; McNemar-Bowker test = 0.069), with the exception of the brief limited intermittent psychotic symptoms (BLIPS) subgroup. Equipercentile-linking table linked symptoms severity and frequency across the CAARMS and SIPS. The conversion algorithm was validated in 93 UHR subjects, showing excellent diagnostic accuracy (CAARMS to SIPS: ROC area 0.929; SIPS to CAARMS: ROC area 0.903). Conclusions. This study provides initial comparability data between CAARMS and SIPS and will inform ongoing multicentre studies and clinical guidelines for the UHR psychometric diagnostic interview.
Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AF, UK; OASIS Service, South London and Maudsley NHS Foundation Trust, London SE11, UK.
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Fusar-Poli
Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AF, UK.
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Cappucciati
Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AF, UK.
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Rutigliano
Department of Psychiatry, Seoul National University College of Medicine, Seoul 08826, Republic of Korea.
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Lee
Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge CB21 5HH, UK.
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Beverly
Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AF, UK; OASIS Service, South London and Maudsley NHS Foundation Trust, London SE11, UK.
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Bonoldi
Real-Time Systems Laboratory, Scuola Superiore Sant'Anna, 56124 Pisa, Italy.
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Lelli
OASIS Service, South London and Maudsley NHS Foundation Trust, London SE11, UK.
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Kaar
OASIS Service, South London and Maudsley NHS Foundation Trust, London SE11, UK.
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Gago
Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AF, UK.
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Rocchetti
Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AF, UK; OASIS Service, South London and Maudsley NHS Foundation Trust, London SE11, UK.
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Patel
Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AF, UK; OASIS Service, South London and Maudsley NHS Foundation Trust, London SE11, UK.
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Bhavsar
Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AF, UK; OASIS Service, South London and Maudsley NHS Foundation Trust, London SE11, UK.
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Tognin
Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AF, UK; OASIS Service, South London and Maudsley NHS Foundation Trust, London SE11, UK.
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Badger
Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AF, UK; OASIS Service, South London and Maudsley NHS Foundation Trust, London SE11, UK.
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Calem
Department of Psychiatry, Seoul National University College of Medicine, Seoul 08826, Republic of Korea.
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Lim
Department of Psychiatry, Seoul National University College of Medicine, Seoul 08826, Republic of Korea.
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Kwon
Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge CB21 5HH, UK; Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, UK.
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Perez
Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AF, UK; OASIS Service, South London and Maudsley NHS Foundation Trust, London SE11, UK.
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McGuire