Safe and Selective Nitro Group Reductions Catalyzed by Sustainable and Recyclable Fe/ppm Pd Nanoparticles in Water at Room Temperature.
As a result of a unique synergy between ligand-free Fe/ppm Pd nanoparticles and PEG-containing designer surfactants, a facile and selective reduction of nitro-containing aromatics and heteroaromatics can be effected in water at room temperature in the presence of NaBH4 . This new nanotechnology involves low catalyst loadings, is highly chemoselective, and tolerates a wide variety of functional groups. The process, which includes recycling of the entire aqueous medium, offers a general, environmentally responsible, and notably safe approach to highly valued reductions of nitro-containing compounds.
Dept. of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.|College of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 2, 10094, P.R. China.
Jie
J
Feng
Dept. of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, 93106, USA. shanda@chem.ucsb.edu.
Sachin
S
Handa
Novartis Pharma, Basel, Switzerland.
Fabrice
F
Gallou
Dept. of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, 93106, USA. lipshutz@chem.ucsb.edu.
Bruce H
BH
Lipshutz
green chemistry; micelles; nanoparticles; reduction; water chemistry