Sex hormone-binding globulin and thrombin generation in women using hormonal contraception.
OBJECTIVE
We investigated the impact of serum sex hormone-binding globulin (SHBG) on thrombin generation (TG) in women according to hormonal contraception.


METHODS
A cross-sectional study of SHBG and TG measured via calibrated automated thrombography was conducted in 150 healthy women, including 75 users of combined oral contraceptives (COC), 22 users of progestin-only contraceptives (POC) and 53 nonusers.


RESULTS
COC but not POC-users had significantly higher SHBG levels compared with nonusers. In hormonal contraceptive users, SHBG was positively associated with both activated protein C (APC) resistance and baseline TG, and protein S and prothrombin were important mediators.


CONCLUSIONS
These data provide further evidence that SHBG may be used as a biomarker in assessing prothrombotic profile of hormonal contraception.
a Inserm, UMR 1018 , Villejuif , France.|b Gynecology Endocrinology Unit , Port-Royal Hospital , Paris , France.|c Faculté de Médecine Paris Descartes , Hôpital Universitaire Paris Centre , Paris , France.
Justine
J
Hugon-Rodin
d Hematology Unit, AP-HP HEGP , Paris , France.
Martine
M
Alhenc-Gelas
e Biochemistry , Maastricht University , Maastricht , Netherlands.
H Coenraad
HC
Hemker
f Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hôpital Bicêtre, APHP , Le Kremlin-Bicêtre , France.|g Inserm, UMR_S1185, Université Paris-Sud, IFR Bicêtre , France.
Sylvie
S
Brailly-Tabard
f Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hôpital Bicêtre, APHP , Le Kremlin-Bicêtre , France.|g Inserm, UMR_S1185, Université Paris-Sud, IFR Bicêtre , France.
Anne
A
Guiochon-Mantel
a Inserm, UMR 1018 , Villejuif , France.|b Gynecology Endocrinology Unit , Port-Royal Hospital , Paris , France.|c Faculté de Médecine Paris Descartes , Hôpital Universitaire Paris Centre , Paris , France.
Geneviève
G
Plu-Bureau
a Inserm, UMR 1018 , Villejuif , France.
Pierre-Yves
PY
Scarabin
D020016:Activated Protein C Resistance / Q000209:etiology; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D015331:Cohort Studies; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D011372:Progestins / Q000008:administration & dosage / Q000009:adverse effects; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013917:Thrombin / Q000096:biosynthesis*; D013927:Thrombosis / Q000139:chemically induced
D015415:Biomarkers; D003277:Contraceptives, Oral, Combined; D003278:Contraceptives, Oral, Hormonal; D011372:Progestins; D012738:Sex Hormone-Binding Globulin; D013917:Thrombin
Biomarkers; hemostasis; prothrombotic