ROS signaling during granzyme B-mediated apoptosis.
Reactive oxygen species (ROS) are involved in cell signaling, aging, and death and play a role in carcinogenesis. However, whether ROS are bystanders or active effectors of apoptosis was unclear until recently. New evidence shows that the killer lymphocyte protease granzyme B activates a conserved biochemical pathway centered on respiratory chain disruption to trigger mitocentric ROS-dependent apoptosis.
Department of Cell Physiology and Metabolism CMU; Geneva University ; Geneva,, Switzerland.
Denis
D
Martinvalet
apoptosis; cell death; granzyme; reactive oxygen species (ROS)