Janus-faced bacterial regulation of epithelial cell death and survival: Association with colon carcinogenesis.
Gut microbiota and lipopolysaccharide (LPS) signaling have been associated with colon cancer development. Our recent findings demonstrated that LPS receptor subunits expressed on colonocytes have antagonistic roles in cell death and tumorigenesis: epithelial toll-like receptor 4 (TLR4) confers resistance to the apoptosis induced by its co-receptor CD14 and contributes to epithelial transition to cancer.
Graduate Institute of Physiology, National Taiwan University College of Medicine.
Wei-Ting
WT
Kuo
Graduate Institute of Physiology, National Taiwan University College of Medicine; Department of Internal Medicine; National Taiwan University Hospital; Taipei, Taiwan, ROC.
Tsung-Chun
TC
Lee
Graduate Institute of Physiology, National Taiwan University College of Medicine.
Linda Chia-Hui
LC
Yu
apoptosis; colorectal carcinoma; innate immunity; intestinal homeostasis; lipopolysaccharide