GlycA, a novel proinflammatory glycoprotein biomarker, and high-sensitivity C-reactive protein are inversely associated with sodium intake after controlling for adiposity: the Prevention of Renal and Vascular End-Stage Disease study.
The extent to which dietary sodium intake may confer alterations in the inflammatory status is unclear. GlycA is a novel proton nuclear magnetic resonance spectroscopy-measured biomarker of systemic inflammation, which is associated with the development of cardiovascular disease and diabetes.



We determined associations of the inflammatory markers GlycA and high-sensitivity C-reactive protein (hsCRP) with 24-h sodium excretion.



A cross-sectional, population-based study was performed in 3935 subjects who were not using an antihypertensive medication, lipid-lowering drugs, or a glucose-lowering treatment. Urinary sodium excretion was calculated as the mean of two 24-h urine excretions. Linear regression models were used, with 24-h sodium excretion as an independent variable and GlycA or ln hsCRP as a dependent variable.



The mean ± SD sodium excretion was 143.0 ± 53.4 mmol/24 h. The GlycA concentration was 343.6 ± 58.7 μmol/L, and the geometric mean of the hsCRP concentration was 1.20 mg/L (95% CI: 1.16, 1.25 mg/L). In age- and sex-adjusted analyses, GlycA and ln hsCRP were not significantly associated with 24-h sodium excretion [B: 1.23 (95% CI: -0.67, 3.13; P = 0.21) and 0.03 (95% CI: -0.004, 0.07; P = 0.08), respectively, per 1-SD increase]. After additional adjustment for body mass index (BMI), both GlycA (B: -2.76; 95% CI: -4.65, -0.86; P = 0.004) and ln hsCRP (B: -0.07; 95% CI: -0.11, -0.04; P < 0.001) were inversely associated with 24-h sodium excretion. These associations were similar if adjustment was performed for waist circumference instead of BMI or if additional adjustment was performed for relevant clinical and laboratory variables and were particularly present in men.



The proinflammatory biomarkers GlycA and hsCRP are inversely related to higher 24-h sodium excretion when taking into account the variation in adiposity. These inverse relations remain present after taking into account other covariates.
Departments of Nephrology and Endocrinology, University of Groningen and University Medical Center Groningen, Groningen, Netherlands; e.g.gruppen@umcg.nl.
Eke G
0000-0002-5259-9882
EG
Gruppen
LipoScience, Laboratory Corporation of America Holdings, Raleigh, NC; and.
Margery A
MA
Connelly
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
Priya
P
Vart
LipoScience, Laboratory Corporation of America Holdings, Raleigh, NC; and.
James D
JD
Otvos
Departments of Nephrology and.
Stephan Jl
SJ
Bakker
Endocrinology, University of Groningen and University Medical Center Groningen, Groningen, Netherlands;
Robin Pf
RP
Dullaart
D000273:Adipose Tissue; D050154:Adiposity; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D003430:Cross-Sectional Studies; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000150:complications; D007674:Kidney Diseases / Q000209:etiology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D012737:Sex Factors; D012982:Sodium, Dietary / Q000494:pharmacology* / Q000652:urine; D055105:Waist Circumference
D015415:Biomarkers; D006023:Glycoproteins; D012982:Sodium, Dietary; D002097:C-Reactive Protein
C-reactive protein; GlycA; diet; glycoproteins; inflammation; nuclear magnetic resonance spectroscopy; sodium excretion