Damage of vascular endothelial barrier induced by explosive blast and its clinical significance.
In recent years, injuries induced by explosive blast have got more and more attention owing to weapon development and frequent terrorist activities. Tear, bleeding and edema of tissues and organs are the main manifestations of blast shock wave damage. Vascular endothelial barrier is the main defense of tissues and organs' integrity. This article aims to discuss possible mechanisms of endothelial barrier damage induced by explosive blast and main manifestations of blood brain barrier, bloodeair barrier, and intestinal vascular barrier impairments. In addition, the main regulatory factors of vascular permeability are also summarized so as to provide theoretical basis for prevention and cure of vascular endothelial barrier damage resulting from explosive blast.
State Key Laboratory of Trauma, Burn and Combined Injury, Research Institute of Surgery/Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Jian-Min
JM
Wang
Jing
J
Chen
D001753:Blast Injuries / Q000378:metabolism*; D001812:Blood-Brain Barrier; D002199:Capillary Permeability; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology; D010972:Platelet Activating Factor / Q000502:physiology; D012701:Serotonin / Q000502:physiology; D013917:Thrombin / Q000502:physiology
D010972:Platelet Activating Factor; D009569:Nitric Oxide; D012701:Serotonin; D013917:Thrombin