Stop relaxing: How DNA damage-induced chromatin compaction may affect epigenetic integrity and disease.
DNA damage is widely recognized for its potential to impair epigenetic integrity. Epigenetic defects are closely associated with a variety of diseases. We have recently uncovered DNA double-strand break-induced chromatin condensation as a critical modulator of repair outcome. Here, we discuss the possible implications for cell functions beyond repair.
Laboratory of Receptor Biology and Gene Expression. National Cancer Institute; NIH ; Bethesda, MD USA.
Philipp
P
Oberdoerffer
DNA repair; chromatin; macroH2A1; replication stress; senescence