Endometriosis allergic or autoimmune disease: pathogenetic aspects--a case control study.
OBJECTIVE
The aim of this study was to evaluate the correlation between endometriosis and pathologies on an immune basis for the possible involvement of the immune system in the pathogenesis of endometriosis.


METHODS
In this retrospective study, data of 304 patients with endometriosis and 318 without endometriosis were collected in a uniform manner for both groups and inserted into two databases, respectively, for patients with and without endometriosis. The authors calculated the percentages of patients with allergies, autoimmune diseases, asthma in both groups, and later statistical analysis were performed with two different chi-square tests.


RESULTS
The results obtained have shown that patients with endometriosis have a higher prevalence of allergies (p = 0.0003) and coexistence of both allergies and autoimmune diseases (p = 0.0274), compared to those without.


CONCLUSIONS
The present study seems to support the possible association between endometriosis and allergic diseases.
D
D
Caserta
M
M
Mallozzi
F M
FM
Pulcinelli
B
B
Mossa
M
M
Moscarini
D000328:Adult; D000938:Antigen-Presenting Cells / Q000276:immunology; D001249:Asthma / Q000453:epidemiology* / Q000276:immunology; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000276:immunology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015897:Comorbidity; D004715:Endometriosis / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000276:immunology; D007111:Immunity, Cellular / Q000276:immunology; D056724:Immunity, Humoral / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology; D018664:Interleukin-12 / Q000276:immunology; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D055815:Young Adult
D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D018664:Interleukin-12