Buccal Dosage Forms: General Considerations for Pediatric Patients.
The development of an appropriate dosage form for pediatric patients needs to take into account several aspects, since adult drug biodistribution differs from that of pediatrics. In recent years, buccal administration has become an attractive route, having different dosage forms under development including tablets, lozenges, films, and solutions among others. Furthermore, the buccal epithelium can allow quick access to systemic circulation, which could be used for a rapid onset of action. For pediatric patients, dosage forms to be placed in the oral cavity have higher requirements for palatability to increase acceptance and therapy compliance. Therefore, an understanding of the excipients required and their functions and properties needs to be particularly addressed. This review is focused on the differences and requirements relevant to buccal administration for pediatric patients (compared to adults) and how novel dosage forms can be less invasive and more acceptable alternatives.
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, 8380494, Santiago, Chile.
Soledad
S
Montero-Padilla
Department of Health Sciences, Luleå University of Technology, 97187, Luleå, Sweden.
Sitaram
S
Velaga
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, 8380494, Santiago, Chile. jomorales@ciq.uchile.cl.|Advanced Center for Chronic Diseases (ACCDiS), 8380494, Santiago, Chile. jomorales@ciq.uchile.cl.
Javier O
JO
Morales
D000278:Administration, Buccal; D006801:Humans; D009055:Mouth / Q000378:metabolism*; D009061:Mouth Mucosa / Q000378:metabolism*; D010372:Pediatrics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D014018:Tissue Distribution
D004364:Pharmaceutical Preparations
buccal delivery; mucoadhesion; pediatric dosage forms; pediatric films; pediatric tablets; transmucosal