Epigenetic regulation of LSD1 during mammary carcinogenesis.
Inheritable epigenetic regulation is integral to the dynamic control of gene expression under different stimuli for cellular homeostasis and disease progression. Histone methylation is a common and important type of chromatin modification. LSD1, the first known histone lysine-specific demethylase, operates as a key component of several corepressor complexes during development and in disease states. In this review, we focus on the regulation of LSD1 in mammary carcinogenesis. LSD1 plays a role in promoting mammary tumor metastasis and proliferation and in maintaining mammary cancer stem cells. Therefore, LSD1 represents a viable therapeutic target for effective treatment of mammary carcinogenesis.
Department of Pharmacology and Nutrition Science; College of Medicine; University of Kentucky; Lexington, KY USA; Markey Cancer Center; College of Medicine; University of Kentucky; Lexington, KY USA.
Yadi
Y
Wu
Markey Cancer Center; College of Medicine; University of Kentucky; Lexington, KY USA; Department of Molecular and Cellular Biochemistry; College of Medicine; University of Kentucky; Lexington, KY USA.
Binhua P
BP
Zhou
LSD1; epigenetic; mammary carcinogenesis