A Meta-Analysis of Randomized Controlled Trials of Yiqi Yangyin Huoxue Method in Treating Diabetic Nephropathy.
Objective. The purpose of this systematic review is to evaluate the evidence of Yiqi Yangyin Huoxue Method for diabetic nephropathy. Methods. 11 electronic databases, through September 2015, were searched to identify randomized controlled trials of Yiqi Yangyin Huoxue Method for diabetic nephropathy. The quality of the included trials was assessed using the Jadad scale. Results. 26 randomized controlled trials were included in our review. Of all the included trials, most of them were considered as high quality. The aggregated results suggested that Yiqi Yangyin Huoxue Method is beneficial to diabetic nephropathy in bringing down the microalbuminuria (SMD = -0.98, 95% CI -1.22 to -0.74), serum creatinine (SMD = -0.56, 95% CI -0.93 to -0.20), beta-2 microglobulin (MD = 0.06, 95% CI 0.01 to 0.12), fasting plasma glucose (MD = -0.35, 95% CI -0.62 to -0.08), and 2-hour postprandial blood glucose (MD = 1.13, 95% CI 0.07 to 2.20), but not in decreasing blood urea nitrogen (SMD = -0.72, 95% CI -1.47 to 0.02) or 2-hour postprandial blood glucose (SMD = -0.48, 95% CI -1.01 to 0.04). Conclusions. Yiqi Yangyin Huoxue Method should be a valid complementary and alternative therapy in the management of diabetic nephropathy, especially in improving UAER, serum creatinine, fasting blood glucose, and beta-2 microglobulin. However, more studies with long follow-up are warrant to confirm the current findings.
Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; Department of Internal Medicine, Shanghai TCM-Integrated Hospital of Shanghai University of Traditional Chinese Medicine, No. 184 Baoding Road, Shanghai 200082, China.
Jiao Ying
JY
Ou
Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China.
Di
D
Huang
Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China.
Yan Sheng
YS
Wu
Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China.
Lin
L
Xu
Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China.
Fei
F
He
Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China.
Hui Ling
HL
Wang
Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China.
Li Qiang
LQ
Shi
Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China.
Qiang
Q
Wan
Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China.
Li Qun
LQ
He
Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China.
Jian
J
Dong Gao