DIAGNOSTIC ACCURACY OF UREA BREATH TEST FOR HELICOBACTER PYLORI INFECTION IN CHILDREN WITH DYSPEPSIA IN COMPARISON TO HISTOPATHOLOGY.
BACKGROUND
Helicobacter pylori infection is the gram negative bacillus with the close association with chronic antral gastritis.


OBJECTIVE
In this study, we evaluate the accuracy of urea breath test (UBT) with carbon isotope 13 in comparison with histopathology of gastric antrum for detection of H. pylori infection in children with dyspepsia.


METHODS
This cross-sectional study was performed at specialized laboratory of Shiraz Gastroenterohepatology Research Center and Nemazee Hospital, Iran, during a 12-months period. This study investigated the sensitivity, specificity, and positive and negative predictive values of UBT in comparison with biopsy-based tests. We included a consecutive selection of 60 children who fulfilled Rome III criteria for dyspepsia. All children were referred for performing UBT with carbon isotope 13 (C13) as well as endoscopy. Biopsies were taken from antrum of stomach and duodenum. The pathologic diagnosis was considered as the standard test.


RESULTS
The mean age of the participants was 10.1±2.6 (range 7-17 years). From our total 60 patients, 28 (46.7%) had positive UBT results and 32 (53.3%) had negative UBT results. Pathologic report of 16 (57.1%) out of 28 patients who had positive UBT were positive for H. pylori and 12 (42.9%) ones were negative. Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively.


CONCLUSIONS
Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Another multicenter study from our country is recommended.
Department of Pediatric Gastroenterology, Shiraz University of Medical Sciences, Shiraz, Iran; , Department of Pediatric Gastroenterology, Shiraz University of Medical Sciences, Shiraz , Iran.
Naser
N
Honar
Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran; , Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz , Iran.
Alireza
A
Minazadeh
Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran; , Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz , Iran.
Nader
N
Shakibazad
Department of Pediatric Gastroenterology, Shiraz University of Medical Sciences, Shiraz, Iran; , Department of Pediatric Gastroenterology, Shiraz University of Medical Sciences, Shiraz , Iran.
Mahmood
M
Haghighat
Shiraz Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; , Shiraz Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz , Iran.
Forough
F
Saki
Chronic Disease Care Research Center and Department of Pediatric Gastroenterology, Abuzar Children's Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Ahvaz Jundishapur University of Medical Sciences, Chronic Disease Care Research Center, Abuzar Children's Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz , Iran.
Hazhir
H
Javaherizadeh
D000293:Adolescent; D001706:Biopsy; D001944:Breath Tests; D002648:Child; D003430:Cross-Sectional Studies; D004415:Dyspepsia / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D004724:Endoscopy; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014508:Urea / Q000032:analysis*
D014508:Urea