Tissue Reaction to Different Types of Calcium Hydroxide Paste in Rat.
The purpose of this study was to compare the biocompatibility of two types of calcium hydroxide paste in subcutaneous tissue in rat. Twenty-two Wistar rats were divided into 4 experimental (n=5 each) and one control (n=2) group. A polyethylene tube filled with either Dentsply or Sure-Paste was implanted in each rat in the experimental groups, while an empty polyethylene tube was used in the control group. After 15 or 60 days, the animals were sacrificed and histopathological examination carried out. Tissue reaction was assessed by inflammatory cell infiltration using a 4-point scoring system, ranging from 0 to 3. Data were analyzed with the Kruskal-Wallis, Wilcoxon, and McNemar tests. Both types of paste induced an inflammatory response at each time point, although the intensity varied. A significant reduction in the number of inflammatory cells was observed at 60 days. Dentsply appeared to induce a more marked inflammatory response at both time points, although the difference was not significant. These results suggest that both types of paste are biocompatible with subcutaneous tissue in rat.
Dental Research Center, Department of Endodontics, Mashhad Dental School, Mashhad University of Medical Sciences.
Mina
M
Zarei
Maryam
M
Javidi
Maryam
M
Gharechahi
Moaied
M
Kateb
Reza
R
Zare
Ziba Shirkhani
ZS
Kelagari
D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects / Q000494:pharmacology; D002126:Calcium Hydroxide / Q000009:adverse effects* / Q000494:pharmacology*; D003094:Collagen / Q000187:drug effects; D004487:Edema / Q000209:etiology; D005347:Fibroblasts / Q000187:drug effects; D005355:Fibrosis / Q000209:etiology; D006098:Granulocytes / Q000187:drug effects / Q000276:immunology; D007249:Inflammation / Q000209:etiology* / Q000276:immunology; D008422:Materials Testing / Q000379:methods*; D009336:Necrosis / Q000209:etiology; D010586:Phagocytes / Q000187:drug effects / Q000276:immunology; D019904:Polymethyl Methacrylate / Q000009:adverse effects / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials / Q000009:adverse effects / Q000494:pharmacology; D040521:Subcutaneous Tissue / Q000187:drug effects* / Q000276:immunology / Q000473:pathology*
D001672:Biocompatible Materials; D012387:Root Canal Filling Materials; C035124:CMW cement; D003094:Collagen; D019904:Polymethyl Methacrylate; D002126:Calcium Hydroxide