PGMA-Based Star-Like Polycations with Plentiful Hydroxyl Groups Act as Highly Efficient miRNA Delivery Nanovectors for Effective Applications in Heart Diseases.
Poly(glycidyl methacrylate)-based star-like polycations with rich hydrophilic hydroxyl groups can efficiently transfer miRNA into primary cardiac fibroblasts for effective applications in cardiac diseases, such as inhibition of cardiac fibrosis and hypertrophy.
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Rui-Quan
RQ
Li
Key Laboratory of Remodeling-Related Cardiovascular Diseases (Ministry of Education), Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, 100029, P. R. China.
Yina
Y
Wu
Key Laboratory of Remodeling-Related Cardiovascular Diseases (Ministry of Education), Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, 100029, P. R. China.
Ying
Y
Zhi
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Xinchao
X
Yang
Key Laboratory of Remodeling-Related Cardiovascular Diseases (Ministry of Education), Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, 100029, P. R. China.
Yulin
Y
Li
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Fu-Jian
FJ
Xua
Key Laboratory of Remodeling-Related Cardiovascular Diseases (Ministry of Education), Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing, 100029, P. R. China.
Jie
J
Du
D000818:Animals; D006331:Heart Diseases / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000008:administration & dosage*; D011073:Polyamines / Q000008:administration & dosage* / Q000737:chemistry*; D000071228:Polyelectrolytes; D011109:Polymethacrylic Acids / Q000008:administration & dosage* / Q000737:chemistry*
D035683:MicroRNAs; D011073:Polyamines; D000071228:Polyelectrolytes; D011109:Polymethacrylic Acids; C042535:polyglycidyl methacrylate
PGEA; fibrosis; heart diseases; hypertrophy; miRNA