Acute effects of nandrolone decanoate on cardiodynamic parameters in isolated rat heart.
Despite worldwide use of anabolic steroids in last decades, there is still contradictory information about their acute influence on myocardium. The aim of this study was to examine the acute effects of nandrolone decanoate (ND) on cardiodynamics and coronary flow in isolated rat heart. The hearts of male Wistar albino rats (n = 48, 12 per group, age 8 weeks, body mass 180-200 g) were excised and perfused according to the Langendorff technique at gradually increased coronary perfusion pressures (40-120 cmH2O). After the control sets of experiments, the hearts in different groups were perfused with different doses of ND (1, 10, or 100 μmol/L separately). Using a sensor placed in the left ventricle, we registered maximum and minimum rate of pressure development in the left ventricle (dP/dtmaxand dP/dtmin), systolic and diastolic left ventricular pressure (SLVP and DLVP), and heart rate (HR). Coronary flow (CF) was measured flowmetrically. The results clearly show the depression in cardiac function caused by higher doses of ND. The highest concentration of ND (100 μmol/L) induced the most deleterious impact on the myocardial function and perfusion of the heart (coronary circulation), which could be of clinical significance.
a Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
Tamara R
TR
Nikolic
b Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Zmaj Jovina 30, 34000 Kragujevac, Serbia.
Vladimir I
VI
Zivkovic
b Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Zmaj Jovina 30, 34000 Kragujevac, Serbia.
Ivan M
IM
Srejovic
c Department of Physiology, Faculty of Sport and Physical Education, University of Nis, Carnojeviceva 10A, 18000 Nis, Serbia.
Dragan S
DS
Radovanovic
a Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
Nevena S
NS
Jeremic
d College of Health Studies in Cuprija, Bulevar Vojske bb, 35230 Cuprija, Serbia.
Maja D
MD
Jevdjevic
e Institute of Medical Physiology "Richard Burian", School of Medicine, University of Belgrade, Visegradska 26, 11000 Belgrade, Serbia.
Dragan M
DM
Djuric
b Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Zmaj Jovina 30, 34000 Kragujevac, Serbia.
Vladimir Lj
VL
Jakovljevic
cardiodynamics; coronary flow; cœur isolé de rat; dynamique cardiaque; décanoate de nandrolone; flux coronarien; isolated rat heart; nandrolone decanoate