Dense fibrillar collagen is a master activator of invadopodia.
Tumor stroma is characterized by abnormal accumulation of dense fibrillar collagen, which promotes tumor progression and metastasis. However, the effect of desmoplastic collagen on cells has been unclear. Our recent findings demonstrate that dense fibrillar collagen activates a novel phosphosignaling mechanism for robust induction of invadopodia in tumor cells and normal fibroblasts.
Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health , Bethesda, MD, USA.
Vira V
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Cell-matrix interactions; dense fibrillar collagen; desmoplasia; extracellular matrix; integrin; invadopodia; invadosomes; metastasis