Adenoid Cystic Carcinoma in a Mexican Population.
OBJECTIVE
To analyze the demographic data, clinical behavior, management (surgery/radiotherapy), disease-free survival (DFS) and overall survival (OS) in Mexican Mestizos with adenoid cystic carcinoma (ACC).


METHODS
A retrospective study comprising all cases with histologic diagnosis of ACC of the head and neck treated from 1986 to 2012.


RESULTS
There were 101 cases (69 women and 32 men), with a mean age of 50 years; mean evolution time before diagnosis was 25 months (range 1-180 months). Most tumors involved maxillary sinus (25.8 %), followed by hard palate (15.9 %) and parotid gland (10.9 %). Surgery was the treatment in 81 cases (80.2 %), radiotherapy alone in 3 cases (3 %), chemo-radiotherapy in 4 cases (4 %) and 13 cases (12.9 %) did not receive any treatment. Post-surgery adjuvant radiotherapy was used in 58 cases (57.4 %); 6 cases (5.9 %) had adjuvant chemo-radiotherapy after surgery and 37 (36.6 %) cases did not receive any adjuvant treatment. Mean follow-up time was 52 months (range 1-288 months). Histologic patterns were cribriform (50.5 %), solid (28.7 %), and tubular (11.9 %) types. OS was 57.6 % and 42.3 % at 5 and 10 years respectively. DFS was 57.8 % at 5 years and 49.7 % at 10 years.


CONCLUSIONS
Initial management in most cases within this series was surgery followed by radiotherapy. There is more to learn about real benefits of molecular therapies. There were no significant differences in DFS and OS depending on site of involvement. OS did not show statistically significant differences amongst patients with positive and negative lymph nodes.
Departament of Head and Neck Surgery, Instituto Nacional de Cancerología, México, USA ; Department of General Surgery, Hospital General Dr. Manuel Gea Gonzalez, México, USA.
Kuauhyama
0000-0002-1862-4036
K
Luna-Ortiz
Departament of Head and Neck Surgery, Instituto Nacional de Cancerología, México, USA.
Veronica
V
Villavicencio-Valencia
Departament of Head and Neck Surgery, Instituto Nacional de Cancerología, México, USA.
Alfredo
A
Rodríguez-Falconi
Universidad Nacional Autonoma de Mexico, Facultad de Psicologia, México, USA.
Nathalie
N
Peteuil
Departamento de Atención a la Salud, Universidad Autónoma Metropolitana Xochimilco, México, USA.
Adalberto
A
Mosqueda-Taylor
Adenoid cystic carcinoma; Head and neck; Salivary glands; Surgery