Computational analysis of mechanical stress-strain interaction of a bioresorbable scaffold with blood vessel.
Crimping and deployment of bioresorbable polymeric scaffold, Absorb, were modelled using a finite element method, in direct comparison with Co-Cr alloy drug eluting stent, Xience V. Absorb scaffold has an expansion rate lower than Xience V stent, with a less outer diameter achieved after balloon deflation. Due to the difference in design and material properties, Absorb also shows a higher recoiling than Xience V, which suggests that additional post-dilatation is required to achieve effective treatment for patients with calcified plaques and stiff vessels. However, Absorb scaffold induces significantly lower stresses on the artery-plaque system, which can be clinically beneficial. Eccentric plaque causes complications to stent deployment, especially non-uniform vessel expansion. Also the stress levels in the media and adventitia layers are considerably higher for the plaque with high eccentricity, for which the choice of stents, in terms of materials and designs, will be of paramount importance. Our results imply that the benefits of Absorb scaffolds are amplified in these cases.
Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Epinal Way, Loughborough LE11 3TU, UK.
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Schiavone
Abbott Vascular, 3200 Lakeside Drive, Santa Clara, CA 95054, USA.
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Abunassar
Abbott Vascular, 3200 Lakeside Drive, Santa Clara, CA 95054, USA.
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Hossainy
Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Epinal Way, Loughborough LE11 3TU, UK. Electronic address: L.Zhao@Lboro.ac.uk.
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Zhao
D020341:Absorbable Implants; D001158:Arteries / Q000473:pathology; D003198:Computer Simulation; D054855:Drug-Eluting Stents; D006801:Humans; D008955:Models, Cardiovascular; D058226:Plaque, Atherosclerotic / Q000628:therapy; D013314:Stress, Mechanical
Bioresorbable scaffold; Eccentric plaque; Stent crimping; Stent deployment; Stresses