Surveillance biopsies after paediatric kidney transplantation: A review.
Kidney transplantation is the most effective means of treating children with end-stage kidney disease, and yet, there continues to be a limited "life span" of transplanted kidneys in paediatric recipients. Early graft monitoring, using the surveillance biopsy, has the potential to extend renal allograft survival in paediatric recipients. The surveillance biopsy provides important and timely information about acute and chronic graft pathology, particularly SCR and calcineurin inhibitor-induced nephrotoxicity, which can subsequently guide management decisions and improve long-term graft survival. The ostensible value of the surveillance biopsy is furthered by the limitations of conventional renal functional studies. However, there is still much debate surrounding the surveillance biopsy in paediatric recipients, particularly in regard to its overall utility, safety and timing. This review discusses the current literature regarding the utility, safety, and potential predictive value of surveillance biopsies for guiding post-transplant management in paediatric renal allograft recipients, as well as the viability of other potentially newer non-invasive strategies for renal allograft monitoring.
School of Women's & Children's Health, UNSW Medicine, University of New South Wales, Sydney, NSW, Australia.
Edward M
EM
Rose
School of Women's & Children's Health, UNSW Medicine, University of New South Wales, Sydney, NSW, Australia.|Nephrology, Sydney Children's Hospital, Randwick, NSW, Australia.
Sean E
SE
Kennedy
School of Women's & Children's Health, UNSW Medicine, University of New South Wales, Sydney, NSW, Australia.|Nephrology, Sydney Children's Hospital, Randwick, NSW, Australia.
Fiona E
FE
Mackie
D000359:Aftercare / Q000379:methods*; D001706:Biopsy; D002648:Child; D006084:Graft Rejection / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control; D006085:Graft Survival; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000473:pathology / Q000601:surgery*; D016030:Kidney Transplantation; D010372:Pediatrics
allograft; biopsy; calcineurin inhibitors; child; graft survival; kidney; kidney transplantation; protocol; rejection transplants