CYP2C19 and CYP2D6 genotypes in Pacific peoples.
The study of pharmacogenetic variants in populations which reside in Oceania has been focused mainly on CYP2C19 and CYP2D6. Statements about the high prevalence of CYP2C19 no function genotype in 'Pacific Islanders' can be found in the literature. This review article summarizes the published information about these pharmacogenes in this geographical region and highlights the differences observed between Melanesian and Polynesian populations. It is not appropriate to combine the prevalence data of pharmacogenetic variants, particularly CYP2C19, across this region. Indeed, apocryphal assumptions about CYP2C19 no function alleles and possible effect on the therapeutic activity of clopidogrel are unhelpful and reiterate the importance of assessing the individual patient rather than relying on inappropriate ethnicity-based assumptions for drug dosing decisions.
School of Medical Sciences, University of Auckland, New Zealand. n.helsby@auckland.ac.nz.
Nuala A
NA
Helsby
D006801:Humans; D065731:Cytochrome P-450 CYP2C19 / Q000235:genetics; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D005838:Genotype; D008542:Melanesia; D000071184:Pharmacogenomic Variants / Q000235:genetics; D011114:Polynesia; D000095188:Pacific Island People / Q000235:genetics
D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6
CYP2C19; CYP2D6; Ethnicity; Pharmacogenetics