Design, Fabrication, Simulation and Characterization of a Novel Dual-Sided Microelectrode Array for Deep Brain Recording and Stimulation.
In this paper, a novel dual-sided microelectrode array is specially designed and fabricated for a rat Parkinson's disease (PD) model to study the mechanisms of deep brain stimulation (DBS). The fabricated microelectrode array can stimulate the subthalamic nucleus and simultaneously record electrophysiological information from multiple nuclei of the basal ganglia system. The fabricated microelectrode array has a long shaft of 9 mm and each planar surface is equipped with three stimulating sites (diameter of 100 μm), seven electrophysiological recording sites (diameter of 20 μm) and four sites with diameter of 50 μm used for neurotransmitter measurements in future work. The performances of the fabricated microelectrode array were characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry. In addition, the stimulating effects of the fabricated microelectrode were evaluated by finite element modeling (FEM). Preliminary animal experiments demonstrated that the designed microelectrode arrays can record spontaneous discharge signals from the striatum, the subthalamic nucleus and the globus pallidus interna. The designed and fabricated microelectrode arrays provide a powerful research tool for studying the mechanisms of DBS in rat PD models.
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. zhaozongya2010@stu.xjtu.edu.cn.|National Engineering Research Center of Health Care and Medical Devices, Xi'an Jiaotong University Branch, Xi'an 710049, China. zhaozongya2010@stu.xjtu.edu.cn.
Zongya
Z
Zhao
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. gongruxue@stu.xjtu.edu.cn.|National Engineering Research Center of Health Care and Medical Devices, Xi'an Jiaotong University Branch, Xi'an 710049, China. gongruxue@stu.xjtu.edu.cn.
Ruxue
R
Gong
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. huanghongen@stu.xjtu.edu.cn.|National Engineering Research Center of Health Care and Medical Devices, Xi'an Jiaotong University Branch, Xi'an 710049, China. huanghongen@stu.xjtu.edu.cn.
Hongen
H
Huang
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. juewang1@126.com.|National Engineering Research Center of Health Care and Medical Devices, Xi'an Jiaotong University Branch, Xi'an 710049, China. juewang1@126.com.
Jue
J
Wang
D000818:Animals; D001921:Brain / Q000503:physiopathology / Q000601:surgery; D046690:Deep Brain Stimulation / Q000379:methods*; D058266:Dielectric Spectroscopy; D005917:Globus Pallidus / Q000503:physiopathology / Q000648:ultrastructure; D008297:Male; D008839:Microelectrodes; D008855:Microscopy, Electron, Scanning; D010300:Parkinson Disease / Q000628:therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020531:Subthalamic Nucleus / Q000503:physiopathology / Q000648:ultrastructure
Parkinson’s disease; dual-sided microelectrode array; mechanisms of deep brain stimulation