Synthesis of Quaternary 3,3-Disubstituted 2-Oxindoles from 2-Substituted Indole Using Selectfluor.
A facile method to construct quaternary 3,3-disubstituted 2-oxindole from 2-substituted indole without a catalyst in mild conditions is developed. A mechanistic study suggests that an iminium-intermediate-triggered 1,2-rearrangement is involved, and a trace amount of water is required for subsequent oxidation.
Institute of New Drug Research, College of Pharmacy, Jinan University , Guangzhou 510632, China.
Xiaojian
X
Jiang
Institute of New Drug Research, College of Pharmacy, Jinan University , Guangzhou 510632, China.
Junjie
J
Yang
Institute of New Drug Research, College of Pharmacy, Jinan University , Guangzhou 510632, China.
Feng
F
Zhang
Institute of New Drug Research, College of Pharmacy, Jinan University , Guangzhou 510632, China.
Pei
P
Yu
Institute of New Drug Research, College of Pharmacy, Jinan University , Guangzhou 510632, China.
Peng
P
Yi
Institute of New Drug Research, College of Pharmacy, Jinan University , Guangzhou 510632, China.
Yewei
Y
Sun
Institute of New Drug Research, College of Pharmacy, Jinan University , Guangzhou 510632, China.
Yuqiang
Y
Wang