Alteration of maternal serum irisin levels in gestational diabetes mellitus.
The aim of our study was to compare serum irisin concentrations in pregnant women with and without ges-tational diabetes mellitus (GDM).



This study was performed at the Tertiary Care Center, Department of Obstetrics and Gynecol-ogy, between January 2014 and April 2014. A total of 45 pregnant women with GDM (diabetes group) and 41 BMI- and age-matched healthy pregnant women (control group) were recruited. Maternal serum irisin levels were measured by enzyme-linked immunosorbent assay kit at 24-28 weeks of gestation. An association between maternal serum irisin lev-els and metabolic parameters was analyzed. Body mass index, serum levels of glucose, insulin and irisin were tested and analyzed in the study group and controls.



Pregnant women with GDM had significantly higher fasting plasma glucose (p = 0.001), first-hour OGTT glucose (p = 0.001), second-hour OGTT glucose (p = 0.001), and fasting insulin (p = 0.045) levels as compared to controls. Serum irisin levels were 1.04 ± 0.3 and 1.3 ± 0.2 in pregnant women with GDM and healthy pregnant controls, respectively (p = 0.001). Correlation analysis between irisin levels and anthropometric and biochemical parameters in patients with gestational diabetes revealed that none of the investigated parameters correlated with serum irisin level.



Our results suggest that serum irisin levels might be introduced as a novel marker for GDM, with decreased levels of irisin being indicative of GDM.
Department of Gynecology and Obstetrics, Recep Tayyip Erdogan University Medical Faculty, Rize, Turkey. ulkumete2004@yahoo.com.
Ulku Mete
UM
Ural
Serap Baydur
SB
Sahin
Yesim Bayoglu
YB
Tekin
Medine Cumhur
MC
Cüre
Hacer
H
Sezgin
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis; D005260:Female; D005353:Fibronectins / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007328:Insulin / Q000097:blood*; D011247:Pregnancy; D015203:Reproducibility of Results; D013223:Statistics as Topic
D015415:Biomarkers; D001786:Blood Glucose; C577593:FNDC5 protein, human; D005353:Fibronectins; D007328:Insulin
gestational diabetes mellitus; glucose; insulin; irisin; pregnant