Four new tetracyclic alkaloids with cis-decahydroquinoline motif from Myrioneuron effusum.
Four new Myrioneuron alkaloids, mysumamides A-D (1-4), along with three known ones were isolated from the twigs and leaves of Myrioneuron effusum. All of these alkaloids possessed the tetracyclic skeleton and contained the decahydroquinoline (cis-DHQ) moiety. Their structures and relative configurations were elucidated on the basis of spectroscopic methods, especially 2D NMR techniques. The absolute configuration of 1 was determined by single-crystal X-ray diffraction. The cytotoxic activities of these compounds were also evaluated in vitro.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
Jia-Hui
JH
Zhang
Yunnan University of TCM, Kunming 650500, Yunnan, PR China.
Jing-Jing
JJ
Guo
Yunnan University of TCM, Kunming 650500, Yunnan, PR China.
Yu-Xi
YX
Yuan
Hainan normal University, Haikou 571158, Hainan, PR China.
Yan-Hui
YH
Fu
Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK.
Yu-Cheng
YC
Gu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
Yu
Y
Zhang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
Duo-Zhi
DZ
Chen
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
Shun-Lin
SL
Li
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China. Electronic address: diyt@mail.kib.ac.cn.
Ying-Tong
YT
Di
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China. Electronic address: haoxj@mail.kib.ac.cn.
Xiao-Jiang
XJ
Hao
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D018360:Crystallography, X-Ray; D015394:Molecular Structure; D064209:Phytochemicals / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry* / Q000302:isolation & purification; D019666:Rubiaceae / Q000737:chemistry*
D000470:Alkaloids; D064209:Phytochemicals; D011804:Quinolines; C037920:decahydroquinoline-5-carboxylic acid
Alkaloids; Myrionamide (PubChem CID: 25105510); Myrioneuron effusum; Myrionidine (PubChem CID: 25067255); Mysumamides A–D; Rubiaceae; Schoberine (PubChem CID: 7278936)