Clinical feasibility of Gd-EOB-DTPA-enhanced MR imaging for assessing liver function: validation with ICG tests and parenchymal cell volume.
OBJECTIVE
Using Gd-EOB-DTPA-enhanced MRI to assess liver function and validate with indocyanine green (ICG) tests and parenchymal cell volume (PCV).


METHODS
Nineteen patients scheduled for operation were enrolled. Functional liver volume (FLV) was computed from 20min post-contrast images. ICG retention was measured in serum 15min after injection. The histological PCV was determined from resected liver specimen.


RESULTS
FLV showed significantly correlated with ICG retention (ICG-R15: r=-0.47, P=.042) and PCV (r=0.814, P<.001).


CONCLUSIONS
Gd-EOB-DTPA-enhanced MRI is clinically feasible for quantifying liver function.
Departments of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung-Shan South Road, Taipei 100, Taiwan; Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, No.155, Sec. 2, Li-Nong St., Taipei 112, Taiwan. Electronic address: macotocc@gmail.com.
Chin-Chen
CC
Chang
Departments of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung-Shan South Road, Taipei 100, Taiwan. Electronic address: hjround@gmail.com.
Hsu-Cheng
HC
Huang
Departments of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung-Shan South Road, Taipei 100, Taiwan. Electronic address: lkl@ntu.edu.tw.
Kao-Lang
KL
Liu
Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung-Shan South Road, Taipei 100, Taiwan. Electronic address: wyaoming@gmail.com.
Yao-Ming
YM
Wu
Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, No.155, Sec. 2, Li-Nong St., Taipei 112, Taiwan. Electronic address: jslee@ym.edu.tw.
Jason J S
JJ
Lee
Departments of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung-Shan South Road, Taipei 100, Taiwan. Electronic address: jiangfen1215@hotmail.com.
Shu-Fen
SF
Jiang
Departments of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung-Shan South Road, Taipei 100, Taiwan. Electronic address: maoyuansu@gmail.com.
Mao-Yuan M
MY
Su
D000328:Adult; D000368:Aged; D048429:Cell Size; D003287:Contrast Media; D005240:Feasibility Studies; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007208:Indocyanine Green; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results
D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D007208:Indocyanine Green; D019786:Gadolinium DTPA
Gd-EOB-DTPA; chronic liver disease; indocyanine green; liver fibrosis; magnetic resonance imaging