Sex Differences in the Recurrence Rate and Risk Factors for Primary Giant Cell Tumors Around the Knee in China.
Although giant cell tumor of bone (GCTB) is more common in women in Western countries, it tends to be more common in men in Asian countries. We aimed to determine the sex differences in clinical characteristics, local recurrence rate, and relevant risk factors for local recurrence in primary GCTB around the knee. Between March 2000 and June 2014, patients with primary GCTB around the knee were recruited from 7 institutions in China, and 410 patients were included. The age at diagnosis was younger in women than in men (34.0 vs 37.2 years). The local recurrence rates were 23.4% overall, 25.8% in men, and 20.7% in women. Lower local recurrence rates were observed with en-bloc marginal resection in both men (6.9%) and women (3.1%). With tumors located in the distal femur, the local recurrence rate was higher for men than for women (29.1% vs 14.3%, P = 0.025). Local recurrence was significantly associated with the tumor location and surgical operation in men and only surgical operation in women. These findings suggest that more aggressive operations should be considered in men with GCTB in the proximal fibula.
Department of Orthopedic Oncology, Tianjin Hospital, 406 Jiefang South Road, Tianjin 300210, China.
Yongcheng
Y
Hu
Department of Orthopedic Oncology, Tianjin Hospital, 406 Jiefang South Road, Tianjin 300210, China.|The Graduate School, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, 300071, China.
Liming
L
Zhao
Department of Orthopedic Oncology, Tianjin Hospital, 406 Jiefang South Road, Tianjin 300210, China.|The Graduate School, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, 300071, China.
Huilin
H
Zhang
Department of Orthopedics, The General Hospital of Jinan Military Commanding Region, 25 Shifan Road, Jinan, Shandong 250031, China.
Xiuchun
X
Yu
Department of Orthopedics, Xijing Hospital, Forth Military Medical University, No. 15 West Changle Road, Xincheng District, Xi'an, Shaanxi, 710032, China.
Zhen
Z
Wang
Centre for Orthopaedic Research, Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University, School of Medicine, 88 Jiefang Road, Hangzhou, 310008, China.
Zhaoming
Z
Ye
Department of Orthopaedics, Jin Ling Hospital, 305 Zhong Shan East Road, Nanjing 210002, Jiangsu Province, China.
Sujia
S
Wu
Orthopedics Department, Second Affiliated Hospital of Inner Mongolia Medical University, 1 Yingfang Road, Huimin District, Hohhot, 010050, P.R. China.
Shibing
S
Guo
Department of Orthopedic Oncology, The Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang 050051, China.
Guochuan
G
Zhang
Department of Epidemiology, Tianjin Neurological Institute &Department of Neurology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
Jinghua
J
Wang
Department of Epidemiology, Tianjin Neurological Institute &Department of Neurology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
Xianjia
X
Ning
D000328:Adult; D001859:Bone Neoplasms / Q000453:epidemiology* / Q000601:surgery; D002681:China / Q000453:epidemiology; D005269:Femur / Q000473:pathology*; D005360:Fibula / Q000473:pathology*; D018212:Giant Cell Tumor of Bone / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery; D006801:Humans; D007717:Knee / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000453:epidemiology*; D012189:Retrospective Studies; D017678:Sex Distribution; D012737:Sex Factors; D055815:Young Adult