Diagnostic implications of intrapatient genetic tumor heterogeneity.
The complex genetic composition of neuroblastoma emphasizes the importance of conscientious and meticulous diagnosis. Clones with amplification or segmental chromosomal aberrations sometimes remain hidden. Several determinations should be performed when sufficient tumor material is available to establish the final diagnosis by combining the results of different techniques on tumor fragments or liquid biopsies.
Pathology Department, Medical School, University of Valencia, INCLIVA Institute , Valencia, Spain.
Ana P
AP
Berbegall
Pathology Department, Medical School, University of Valencia, INCLIVA Institute , Valencia, Spain.
Samuel
S
Navarro
Pathology Department, Medical School, University of Valencia, INCLIVA Institute , Valencia, Spain.
Rosa
R
Noguera
Heterogeneous MYCN amplification; heterogeneous segmental chromosome aberration; intratumoral genetic heterogeneity; neuroblastoma; spatial intrapatient genetic heterogeneity; temporal genetic heterogeneity