AEG-1-AKT2: A novel complex controlling the aggressiveness of glioblastoma.
Expression of AEG-1 (also known as MTDH or LYRIC) is elevated in many cancers including glioblastoma multiforme (GBM), in which it functions as an oncogene. AEG-1 activates AKT signaling and physically interacts with AKT2 in GBM. Disruption of this interaction reduces glioma cell survival and invasion, uncovering a novel potential target for development of an effective therapy against GBM.
Department of Human and Molecular Genetics; VCU Institute of Molecular Medicine; VCU Massey Cancer Center; Virginia Commonwealth University; School of Medicine; Richmond, VA, USA.
Luni
L
Emdad
Department of Human and Molecular Genetics.
Bin
B
Hu
Department of Human and Molecular Genetics; VCU Institute of Molecular Medicine; VCU Massey Cancer Center; Virginia Commonwealth University; School of Medicine; Richmond, VA, USA.
Swadesh K
SK
Das
Department of Human and Molecular Genetics; VCU Institute of Molecular Medicine; VCU Massey Cancer Center; Virginia Commonwealth University; School of Medicine; Richmond, VA, USA.
Devanand
D
Sarkar
Department of Human and Molecular Genetics; VCU Institute of Molecular Medicine; VCU Massey Cancer Center; Virginia Commonwealth University; School of Medicine; Richmond, VA, USA.
Paul B
PB
Fisher
AEG-1; AKT2; MTDH; glioblastoma