Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?
The system XC (-)/glutathione/glutathione peroxidase 4 (Gpx4) axis pivotally controls ferroptosis, a recently described form of regulated non-apoptotic cell death. Compelling evidence has established that this route of cell death is not only of high relevance for triggering cancer cell death, but also proves to be amenable for therapeutic intervention to halt ischemia/reperfusion-related diseases.
Institute of Developmental Genetics; Helmholtz Zentrum München; , München, Germany.
Marcus
M
Conrad
Institute of Developmental Genetics; Helmholtz Zentrum München; , München, Germany.
José Pedro
JP
Friedmann Angeli
cell death; lipid peroxidation; non-apoptotic cell death; regulated necrosis