PrimPol-A new polymerase on the block.
The DNA-directed primase-polymerase PrimPol of the archaeo-eukaryotic primase superfamily represents an ancient solution to the many problems faced during genome duplication. This versatile enzyme is capable of initiating de novo DNA/RNA synthesis, DNA chain elongation, and has the capacity to bypass modifications that stall the replisome by trans-lesion synthesis or origin-independent re-priming, thus allowing discontinuous synthesis of the leading strand. Recent studies have shown that PrimPol is an important new player in replication fork progression in eukaryotic cells; this review summarizes our current understanding of PrimPol and highlights important questions that remain to be addressed.
Genome Damage and Stability Center; University of Sussex ; Brighton, UK.
Sean G
SG
Rudd
Present address: Department of Oncology-Pathology; Cancer Center Karolinska; Karolinska Institutet ; Stockholm, Sweden.
Julie
J
Bianchi
Genome Damage and Stability Center; University of Sussex ; Brighton, UK.
Aidan J
AJ
Doherty
AEP; DNA; PrimPol; TLS; lesions; polymerase; primase; replication; repriming; restart