Interaction between Helicobacter pylori and host genetic variants in gastric carcinogenesis.
Helicobacter pylori (H. pylori) is the definite carcinogen of gastric cancer. H. pylori infection induces chronic inflammation, causes DNA damage and aberrant methylation of genes and these pathways are involved in H. pylori-related gastric carcinogenesis. Polymorphisms of the genes involved in these pathways could alter susceptibility to gastric cancer. In this mini review, we focused on the role of polymorphisms in these genes on the susceptibility to gastric cancer, with a particular emphasis on their possible interactions with H. pylori infection. We found that many studies on this theme did not simultaneously report H. pylori infection and the interactions remained inconclusive.
Division of Clinical Research, First Hospital of Jilin University, Changchun 130021, China.|Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110112, China.
Zhi-Fang
ZF
Jia
Department of Gynecological Oncology, First Hospital of Jilin University, Changchun 130021, China.
Song-Ling
SL
Zhang
Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun 130021, China.
Xue-Yuan
XY
Cao
Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110112, China.
Bao-Sen
BS
Zhou
Division of Clinical Research, First Hospital of Jilin University, Changchun 130021, China.
Jing
J
Jiang
D015415:Biomarkers; D063646:Carcinogenesis; D019175:DNA Methylation; D004260:DNA Repair; D004198:Disease Susceptibility; D015972:Gene Expression Regulation, Neoplastic; D014644:Genetic Variation; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology*; D016480:Helicobacter pylori; D054884:Host-Pathogen Interactions; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000209:etiology* / Q000378:metabolism
D015415:Biomarkers
DNA damage; Helicobacter pylori; gastric cancer; inflammation; methylation; polymorphism