Excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency.
Excessive fluoride consumption leads to accelerated red blood cell death and anaemia. Whether that increases the haematological alteration in subjects with haematological disorders (iron deficiency, thalassaemia, and G-6-PD deficiency) is still unclear. The fluoride in serum and urine and haematological parameters of students at Mae Tuen School (fluoride endemic area) were analysed and compared to those of students at Baan Yang Poa and Baan Mai Schools (control areas). Iron deficiency, thalassaemia, and G-6-PD deficiency were also diagnosed in these students. The students at Mae Tuen School had significantly (P < 0.001) higher levels of mean fluoride in the serum and urine than those in control areas. In both control and fluoride endemic areas, students with haematological disorders had significantly lower levels of Hb, Hct, MCV, MCH, and MCHC than those without haematological disorders. Moreover, the lowest levels of Hb, MCH, and MCHC were observed in the students with haematological disorders who live in the fluoride endemic area. Thus, the excessive fluoride consumption increased haematological alteration in subjects with iron deficiency, thalassaemia, and G-6-PD deficiency and that may increase the risk of anaemia in these subjects.
Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroros Road, Chiang Mai, 50200, Thailand. sakornmi001@gmail.com.
Sakorn
S
Pornprasert
The Dental Research Center, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
Phenphichar
P
Wanachantararak
Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroros Road, Chiang Mai, 50200, Thailand.
Fahsai
F
Kantawong
Intercountry Centre for Oral Health, Chiang Mai, Thailand.
Supoj
S
Chamnanprai
Intercountry Centre for Oral Health, Chiang Mai, Thailand.
Chatpat
C
Kongpan
Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroros Road, Chiang Mai, 50200, Thailand.
Nattasit
N
Pienthai
Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroros Road, Chiang Mai, 50200, Thailand.
Jintana
J
Yanola
Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroros Road, Chiang Mai, 50200, Thailand.
Suwit
S
Duangmano
Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Mujalin
M
Prasannarong
D000293:Adolescent; D018798:Anemia, Iron-Deficiency / Q000097:blood* / Q000652:urine*; D016923:Cell Death; D002648:Child; D004909:Erythrocyte Indices; D004912:Erythrocytes; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood / Q000652:urine; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood* / Q000652:urine*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D013785:Thailand; D013789:Thalassemia / Q000097:blood* / Q000652:urine*; D055815:Young Adult
D006454:Hemoglobins; D005459:Fluorides
Anaemia; Fluoride; G-6-PD deficiency; Iron deficiency; Thalassaemia