Crystal structure of canagliflozin hemihydrate.
There are two canagliflozin mol-ecules (A and B) and one water mol-ecule in the asymmetric unit of the title compound, C24H25FO5S·0.5H2O [systematic name: (2S,3R,4R,5S,6R)-2-(3-{[5-(4-fluoro-phen-yl)thio-phen-2-yl]meth-yl}-4-methylphen-yl)-6-(hy-droxy-meth-yl)-3,4,5,6-tetra-hydro-2H-pyran-3,4,5-triol hemihydrate]. The dihedral angles between the methyl-benzene and thio-phene rings are 115.7 (4) and 111.7 (4)°, while the dihedral angles between the fluoro-benzene and thio-phene rings are 24.2 (6) and 20.5 (9)° in mol-ecules A and B, respectively. The hydro-pyran ring exhibits a chair conformation in both canagliflozin mol-ecules. In the crystal, the canagliflozin mol-ecules and lattice water mol-ecules are connected via O-H⋯O hydrogen bonds into a three-dimensional supra-molecular architecture.
Chemistry Department, Zhejiang University, Hangzhou, Zhejiang 310028, People's Republic of China.
Kai-Hang
KH
Liu
Center of Analysis and Measurement, Zhejiang University, Hangzhou, Zhejiang 310028, People's Republic of China.
Jian-Ming
JM
Gu
Chemistry Department, Zhejiang University, Hangzhou, Zhejiang 310028, People's Republic of China.
Xiu-Rong
XR
Hu
Chemistry Department, Zhejiang University, Hangzhou, Zhejiang 310028, People's Republic of China.
Gu-Ping
GP
Tang
canagliflozin; crystal structure; hydrogen bonding