The programmed cell death GLuc PCA library - a powerful tool for pathway discovery and drug screening.
A programmed cell death library based on the Gaussia luciferase protein-fragment complementation assay (GLuc PCA) enables detection of protein-protein interactions (PPI) within the cell death network and quantitative assessments of these interactions. Among future applications for the GLuc PCA cell death library is its potential use as a platform for PPI-targeted drug screening.
Department of Molecular Genetics; Weizmann Institute of Science ; Rehovot, Israel.
Yuval
Y
Gilad
Department of Molecular Genetics; Weizmann Institute of Science ; Rehovot, Israel.
Adi
A
Kimchi
DAPK2; apoptosis; autophagy; programmed cell death; protein-fragment complementation assay; protein-protein interaction