Epistatic interaction between MyD88 and TIRAP against Helicobacter pylori.
The genes MyD88 and TIRAP encode the adaptor proteins MyD88 and TIRAP. TIRAP plays the crucial role of activating the MyD88-dependent pathway, which in turn controls the immune response (innate and adaptive) to Helicobacter pylori. We looked for an association of MyD88 and TIRAP with H. pylori infection. Cases and controls were genotyped at the polymorphic sites MyD88 rs6853 and TIRAP rs8177374 by real-time PCR. When the genes were analyzed separately, only TIRAP was associated with infection. When the genes were analyzed concurrently, certain combinations of MyD88 and TIRAP protected the host against H. pylori colonization more efficiently than could be done by TIRAP alone.
University of Naples 'Federico II', Italy.
Andrea
A
Fulgione
University of Naples 'Federico II', Italy.
Antonio
A
Di Matteo
University of Naples 'Federico II', Italy.
Felice
F
Contaldi
University of Naples 'Federico II', Italy.
Rosanna
R
Manco
University of Naples 'Federico II', Italy.
Flora
F
Ianniello
University of Naples 'Federico II', Italy.
Guido
G
Incerti
Fondazione Evangelica Betania, Naples, Italy.
Massimiliano
M
De Seta
Fondazione Evangelica Betania, Naples, Italy.
Nicolino
N
Esposito
University of Naples 'Federico II', Italy.
Antonio
A
Crasto
University of Naples 'Federico II', Italy.
Domenico
D
Iannelli
University of Naples 'Federico II', Italy.
Rosanna
R
Capparelli
D000328:Adult; D004843:Epistasis, Genetic / Q000276:immunology*; D005260:Female; D016481:Helicobacter Infections / Q000235:genetics / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology; D008875:Middle Aged; D053594:Myeloid Differentiation Factor 88 / Q000235:genetics / Q000276:immunology; D011110:Polymorphism, Genetic / Q000276:immunology*; D017472:Receptors, Interleukin-1 / Q000235:genetics / Q000276:immunology
C507779:MYD88 protein, human; D008562:Membrane Glycoproteins; D053594:Myeloid Differentiation Factor 88; D017472:Receptors, Interleukin-1; C434984:TIRAP protein, human
Helicobacter pylori; MyD88; TIRAP; epistasis