Regioselective 2,2,2-Trifluoroethylation of Imidazopyridines by Visible Light Photoredox Catalysis.
A visible-light-induced C-3 selective trifluoroethylation of imidazoheterocycles using 1,1,1-trifluoro-2-iodoethane as trifluoroethyl radical sources was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with excellent regioselectivities and high functional group tolerance.
College of Chemistry and Chemical Engineering, and Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University , Luoyang 471022, China.
Mei
M
Zhu
College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450052, China.
Xin
X
Han
College of Chemistry and Chemical Engineering, and Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University , Luoyang 471022, China.
Weijun
W
Fu
College of Chemistry and Chemical Engineering, and Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University , Luoyang 471022, China.
Zhiqiang
Z
Wang
College of Chemistry and Chemical Engineering, and Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University , Luoyang 471022, China.
Baoming
B
Ji
College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450052, China.
Xin-Qi
XQ
Hao
College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450052, China.
Mao-Ping
MP
Song
College of Chemistry and Chemical Engineering, and Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University , Luoyang 471022, China.
Chen
C
Xu