Non-alcoholic fatty liver disease (NAFLD) in different populations: A clinical and epidemiological study - sample of São José do Rio Preto.
BACKGROUND
NAFLD is an heterogeneous condition that includes steatosis and non-alcoholic steatohepatitis (NASH), in the absence of significant alcohol consumption, reaching 30% of the population. The most common risk factors are: age, gender, ethnicity, diabetes mellitus (DM), obesity, predisposition, metabolic syndrome (MS), insulin resistance (IR), drugs, and polycystic ovary syndrome.


OBJECTIVE
To describe the profile of patients with NAFLD seen at Hospital de Base of Rio Preto, in the state of São Paulo.


METHODS
Patients with NAFLD were assessed, with medical and epidemiological data collected after informed consent.


RESULTS
Of the 62 patients evaluated, 76% were women, 73% Caucasians, and 71% were aged between 50 and 69 years and had no symptoms. Ultrasonography results showed steatosis in 84%. NASH was diagnosed in 61% of the sample. 21 patients underwent liver biopsy, of which 36% had cirrhosis, 1 had liver cancer, and 1 pure steatosis (5% each). Risk factors were found in 70% of patients with metabolic syndrome, 87% with increased waist circumference, 63% with dyslipidemia, 61% (n=38) with high blood pressure (HBP), 28% with DM, 52% physically inactive, and 44% with insulin resistance (IR) (HOMA> 3.5). There was an association between IR and NASH (p=0.013), IR and obesity (p=0.027), IR and MS (p=0.006), and MS and steatosis on medical ultrasound (USG) (p=0.014).


CONCLUSIONS
The most frequent risk factors were MS and its variables: increased waist circumference, dyslipidemia and HBP. This underscores the importance of metabolic control in NAFLD and confirms its role as the hepatic component of metabolic syndrome.
Associação Médica Brasileira, Conselho Brasileiro de Oftalmologia, Associação Médica Brasileira, São Paulo SP , Brazil, MD, Specialist degree in Ophthalmology from Associação Médica Brasileira (AMB) and Conselho Brasileiro de Oftalmologia (CBO), São Paulo, SP.
Gabriel Costa de
GC
Andrade
Federação Brasileira das Associções de Ginecologia e Obstetrícia, Federação Brasileira das Associções de Ginecologia e Obstetrícia, São Paulo SP , Brazil, Gynecologist - Specialist degree in Gynecology and Obstetrics from AMB and Federação Brasileira das Associções de Ginecologia e Obstetrícia (Febrasgo), São Paulo, SP, Brazil.
Luciana Harumi
LH
Fujise
Federação Brasileira das Associções de Ginecologia e Obstetrícia, Federação Brasileira das Associções de Ginecologia e Obstetrícia, São Paulo SP , Brazil, Gynecologist - Specialist degree in Gynecology and Obstetrics from AMB and Federação Brasileira das Associções de Ginecologia e Obstetrícia (Febrasgo), São Paulo, SP, Brazil.
Jaime Euclides de
JE
Santana
Faculdade de Medicina de São José do Rio Preto, Faculdade de Medicina de São José do Rio Preto, Department of Nutrition, São José do Rio Preto SP , Brazil, Department of Nutrition - Faculdade de Medicina de São José do Rio Preto (Famerp), São José do Rio Preto, SP, Brazil.
Fabiane
F
Oliveira
Faculdade de Medicina de São José do Rio Preto, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto SP , Brazil, PhD in Gastroenterology from Universidade Estadual de Campinas (Unicamp). PhD Professor, Faculdade de Medicina de São José do Rio Preto (Famerp), São José do Rio Preto, SP, Brazil.
Rita de Cássia Martins Alves da
Rde C
Silva
D000328:Adult; D001706:Biopsy; D001938:Brazil / Q000453:epidemiology; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D009765:Obesity / Q000150:complications; D015995:Prevalence; D012016:Reference Values; D012307:Risk Factors; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D055105:Waist Circumference