Prostate cancer and the unfolded protein response.
The endoplasmic reticulum (ER) is an essential organelle that contributes to several key cellular functions, including lipogenesis, gluconeogenesis, calcium storage, and organelle biogenesis. The ER also serves as the major site for protein folding and trafficking, especially in specialized secretory cells. Accumulation of misfolded proteins and failure of ER adaptive capacity activates the unfolded protein response (UPR) which has been implicated in several chronic diseases, including cancer. A number of recent studies have implicated UPR in prostate cancer (PCa) and greatly expanded our understanding of this key stress signaling pathway and its regulation in PCa. Here we summarize these developments and discuss their potential therapeutic implications.
Department of Biosciences, University of Oslo, Oslo, Norway.
Margrethe
M
Storm
Department of Biosciences, University of Oslo, Oslo, Norway.
Xia
X
Sheng
Department of Biological and Chemical Work Environment, National Institute of Occupational Health, Oslo, Norway.
Yke Jildouw
YJ
Arnoldussen
Department of Biosciences, University of Oslo, Oslo, Norway.|Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.
Fahri
F
Saatcioglu
D000818:Animals; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms; D056811:Unfolded Protein Response
endoplasmic reticulum stress; prostate cancer; therapeutic targeting; unfolded protein response