Automated library synthesis of cyclopropyl boronic esters employing diazomethane in a tube-in-tube flow reactor.
The efficient synthesis of cyclopropyl boronic esters in library format using a diazomethane flow reactor has been achieved. A pivotal component of the system is a fully automated tube-in-tube reactor allowing for safe handling of hazardous diazomethane on repeated small scale and for the generation of larger quantities of product. The setup enables the repeated execution of Pd-catalyzed cyclopropanation reactions without compromising its operation over time.
AbbVie, Discovery Chemistry and Technology, 1 North Waukegan Road, North Chicago, IL 60064, USA. hannes.koolman@abbvie.com.
Hannes F
HF
Koolman
AbbVie, SPaRCS: SPecialized Research in Chaotic Systems, 1 North Waukegan Road, North Chicago, IL 60064, USA. stan.kantor@abbvie.com.
Stanislaw
S
Kantor
AbbVie, Discovery Chemistry and Technology, 1 North Waukegan Road, North Chicago, IL 60064, USA. hannes.koolman@abbvie.com.
Andrew R
AR
Bogdan
AbbVie, Discovery Chemistry and Technology, 1 North Waukegan Road, North Chicago, IL 60064, USA. hannes.koolman@abbvie.com.
Ying
Y
Wang
AbbVie, SPaRCS: SPecialized Research in Chaotic Systems, 1 North Waukegan Road, North Chicago, IL 60064, USA. stan.kantor@abbvie.com.
Jeffrey Y
JY
Pan
AbbVie, Discovery Chemistry and Technology, 1 North Waukegan Road, North Chicago, IL 60064, USA. hannes.koolman@abbvie.com.
Stevan W
SW
Djuric