Effects of exercise in a relapsing-remitting model of experimental autoimmune encephalomyelitis.
Previous research has examined the effects of exercise in experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis. However, all previous studies have utilized a chronic model of EAE, with exercise delivered prior to or immediately after induction of EAE. To our knowledge, no study has examined the effects of exercise delivered during a remission period after initial disease onset in a relapsing-remitting model of EAE (RR-EAE). The current study examines the effects of both voluntary wheel running and forced treadmill exercise on clinical disability and hippocampal brain-derived neurotrophic factor (BDNF) in SJL mice with RR-EAE. The results demonstrate no significant effects of exercise delivered during remission after initial disease onset on clinical disability scores or levels of hippocampal BDNF in mice with RR-EAE. Furthermore, our results demonstrate no significant increase in citrate synthase activity in the gastrocnemius and soleus muscles of mice in the running wheel or treadmill conditions compared with the sedentary condition. These results suggest that the exercise stimuli might have been insufficient to elicit differences in clinical disability or hippocampal BDNF among treatment conditions. © 2016 Wiley Periodicals, Inc.
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Rachel E
RE
Klaren
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Ulana
U
Stasula
Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Andrew J
AJ
Steelman
Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Jessica
J
Hernandez
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Brandt D
BD
Pence
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Jeffrey A
JA
Woods
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Robert W
RW
Motl
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002950:Citrate (si)-Synthase / Q000378:metabolism; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D005080:Exercise Test; D005260:Female; D005620:Freund's Adjuvant / Q000633:toxicity; D006624:Hippocampus / Q000378:metabolism; D051379:Mice; D009043:Motor Activity / Q000502:physiology; D009103:Multiple Sclerosis / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D009132:Muscles / Q000473:pathology; D018991:Myelin Proteolipid Protein / Q000276:immunology / Q000633:toxicity; D009929:Organ Size; D010446:Peptide Fragments / Q000276:immunology / Q000633:toxicity; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011897:Random Allocation; D012008:Recurrence; D012420:Running / Q000502:physiology; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology
D019208:Brain-Derived Neurotrophic Factor; D018991:Myelin Proteolipid Protein; D010446:Peptide Fragments; C435023:myelin proteolipid protein (139-151); D005620:Freund's Adjuvant; D002950:Citrate (si)-Synthase
BDNF; EAE; RRID:MGI_2663948; RRID:SCR_002865; exercise