Meta-analysis of the IL-10 promoter polymorphisms and pediatric asthma susceptibility.
The results of previous epidemiological studies exploring the relationship between interleukin-10 (IL-10) promoter polymorphisms and susceptibility to pediatric asthma are not consistent. Therefore, we have performed a systematic review and meta-analysis to provide a more convincing conclusion. Odds ratios (OR) with their 95% confidence intervals (CIs) were used to evaluate the strength of association between the IL-10 promoter polymorphisms and susceptibility to pediatric asthma. Publication bias was examined by Begg's funnel plots and the Egger test. A detailed literature search based on stringent parameters yielded sixteen relevant studies, comprising 2494 cases and 2160 controls. The overall population showed no significant association between the IL-10 -1082G/A polymorphism and pediatric asthma risk in any of the genetic models (dominant model: OR = 1.583, 95%CI = 0.614-4.076, P = 0.342; allelic model: OR = 1.214, 95%CI = 0.748-1.971, P = 0.433; additive model: OR = 2.240, 95%CI = 0.950-5.277, P = 0.065; recessive model: OR = 1.435, 95%CI = 0.659-3.128, P = 0.363). Subgroup analyses revealed a significant association between different ethnicity and atopic status subgroups. However, there was no evidence of a significant association between the other two polymorphisms (-819C/ T and -592C/A) and pediatric asthma in our study. No significant publication bias was observed in this meta-analysis. The results of this study indicate that the IL-10 -1082G/A polymorphism might be a risk factor for asthma in children. However, because of the small sample size included in the subgroup analyses, the results should be interpreted with caution.
Department of Pediatrics, No. 2 Hospital of Changzhou, Jiangsu, China.
Z Y
ZY
Huang
Department of Pediatrics, No. 2 Hospital of Changzhou, Jiangsu, China.
B J
BJ
Cheng
Department of Pediatrics, No. 2 Hospital of Changzhou, Jiangsu, China.
Y
Y
Wan
Department of Pediatrics, No. 2 Hospital of Changzhou, Jiangsu, China.
C
C
Zhou
D000483:Alleles; D044466:Asian People; D001249:Asthma / Q000235:genetics* / Q000473:pathology; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012307:Risk Factors
C508609:IL10 protein, human; D016753:Interleukin-10