Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides.
Applications of silica-ROMP reagents in a one-pot, sequential protocol have been developed for the synthesis of a variety of diverse benzoxathiazepine 1,1-dioxides. This protocol includes sulfonylation, intramolecular SNAr, alkylation with silica-supported oligomeric benzyl (Si-OBPn) and triazole (Si-OTPn) phosphates, and intermolecular SNAr addition with a number of secondary amines in one-pot to afford a variety of unique benzoxathiazepine 1,1-dioxides sultams in good to excellent yields.
Department of Chemistry, University of Kansas , 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582, United States.|The University of Kansas Center for Chemical Methodologies and Library Development (KU-CMLD) , 2034-Becker Drive, Delbert M. Shankel Structural Biology Center, Lawrence, Kansas 66047, United States.
Saqib
S
Faisal
Department of Chemistry, University of Kansas , 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582, United States.|The University of Kansas Center for Chemical Methodologies and Library Development (KU-CMLD) , 2034-Becker Drive, Delbert M. Shankel Structural Biology Center, Lawrence, Kansas 66047, United States.
Pradip K
PK
Maity
Department of Chemistry, University of Kansas , 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582, United States.|The University of Kansas Center for Chemical Methodologies and Library Development (KU-CMLD) , 2034-Becker Drive, Delbert M. Shankel Structural Biology Center, Lawrence, Kansas 66047, United States.
Qin
Q
Zang
Department of Chemistry, University of Kansas , 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582, United States.|The University of Kansas Center for Chemical Methodologies and Library Development (KU-CMLD) , 2034-Becker Drive, Delbert M. Shankel Structural Biology Center, Lawrence, Kansas 66047, United States.
Thiwanka B
TB
Samarakoon
Department of Chemistry, University of Kansas , 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582, United States.|The University of Kansas Center for Chemical Methodologies and Library Development (KU-CMLD) , 2034-Becker Drive, Delbert M. Shankel Structural Biology Center, Lawrence, Kansas 66047, United States.
Robert L
RL
Sourk
Department of Chemistry, University of Kansas , 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582, United States.|The University of Kansas Center for Chemical Methodologies and Library Development (KU-CMLD) , 2034-Becker Drive, Delbert M. Shankel Structural Biology Center, Lawrence, Kansas 66047, United States.
Paul R
PR
Hanson
D000477:Alkylating Agents / Q000737:chemistry*; D000478:Alkylation; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D001593:Benzyl Compounds / Q000138:chemical synthesis; D007202:Indicators and Reagents; D010087:Oxides; D010710:Phosphates / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013237:Stereoisomerism; D013841:Thiazepines / Q000138:chemical synthesis*; D014230:Triazoles / Q000138:chemical synthesis
D000477:Alkylating Agents; D000588:Amines; D001593:Benzyl Compounds; D007202:Indicators and Reagents; D010087:Oxides; D010710:Phosphates; D013841:Thiazepines; D014230:Triazoles; D012822:Silicon Dioxide
SNAr; Si-immobilized reagents; alkylation; benzoxathiazepine 1,1-dioxides; one-pot