Association between polymorphisms in IL21 gene and risk for sepsis.
BACKGROUND
Sepsis is now the leading cause of death in the noncardiovascular intensive care unit (ICU).


OBJECTIVE
To investigate whether polymorphisms in IL21 gene contribute to sepsis susceptibility.


METHODS
Three single-nucleotide polymorphisms of IL21 (rs907715, rs2055979, rs12508721) were genotyped by TaqMan assay in patients with sepsis and control subjects.


RESULTS
Polymorphisms rs2055979 and rs12508721 in IL21 were more frequent in sepsis patients compared to general population. But allele frequency of rs907715 was not significantly different between sepsis patients and control subjects.


CONCLUSIONS
Polymorphisms in IL21 may be associated with sepsis risk.
a Vascular Surgery of West China School of Medicine , Sichuan University Chengdu , Sichuan , P.R. China.
Tianyu
T
Miao
b Department of Forensic Biology, West China School of Preclinical and Forensic Medicine , Sichuan University , Chengdu , Sichuan , P.R. China.
Yan
Y
Pu
c Laboratory of Molecular Translational Medicine , West China Second University Hospital, Sichuan, Western China School of Medicine, Sichuan University , Chengdu , Sichuan , P.R. China.
Bin
B
Zhou
b Department of Forensic Biology, West China School of Preclinical and Forensic Medicine , Sichuan University , Chengdu , Sichuan , P.R. China.
Peng
P
Chen
c Laboratory of Molecular Translational Medicine , West China Second University Hospital, Sichuan, Western China School of Medicine, Sichuan University , Chengdu , Sichuan , P.R. China.
Yanyun
Y
Wang
c Laboratory of Molecular Translational Medicine , West China Second University Hospital, Sichuan, Western China School of Medicine, Sichuan University , Chengdu , Sichuan , P.R. China.
Yaping
Y
Song
a Vascular Surgery of West China School of Medicine , Sichuan University Chengdu , Sichuan , P.R. China.
Jichun
J
Zhao
b Department of Forensic Biology, West China School of Preclinical and Forensic Medicine , Sichuan University , Chengdu , Sichuan , P.R. China.|c Laboratory of Molecular Translational Medicine , West China Second University Hospital, Sichuan, Western China School of Medicine, Sichuan University , Chengdu , Sichuan , P.R. China.
Lin
L
Zhang
D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007362:Intensive Care Units; D007378:Interleukins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D018805:Sepsis / Q000235:genetics*; D000098546:Interleukin-21
D007378:Interleukins; D000098546:Interleukin-21
Cytokine; IL-21; genetic susceptibility; polymorphism; sepsis