Lead generation in crop protection research: a portfolio approach to agrochemical discovery.
The need for increased food and feed supply to support future global demand with the added challenges of resistance pressure and an evolving regulatory environment necessitates the discovery of new crop protection agents for growers of today and tomorrow. Lead generation is the critical 'engine' for maintaining a robust pipeline of new high-value products. A wide variety of approaches exist for the generation of new leads, many of which have demonstrated success. Each approach features some degree of merit or benefit while also having some inherent drawback or level of risk. While risk for any single approach can be mitigated in a variety of different ways depending on the approach, long-term viability of a successful lead generation program merits utilization of a portfolio of different approaches and methodologies for the generation of new leads. © 2016 Society of Chemical Industry.
Dow AgroSciences, Discovery Research, Indianapolis, IN, USA.
Michael R
MR
Loso
Dow AgroSciences, Discovery Research, Indianapolis, IN, USA.
Negar
N
Garizi
Dow AgroSciences, Discovery Research, Indianapolis, IN, USA.
Vidyadhar B
VB
Hegde
Dow AgroSciences, Discovery Research, Indianapolis, IN, USA.
James E
JE
Hunter
Dow AgroSciences, Discovery Research, Indianapolis, IN, USA.
Thomas C
TC
Sparks
D016573:Agrochemicals / Q000032:analysis* / Q000737:chemistry*; D000069601:Crop Protection / Q000639:trends*
D016573:Agrochemicals
Isoclast™ active; bioactive hypothesis; discovery; lead generation; microcolin; natural products; novel scaffolds; sulfoxaflor