Geometry reconstruction method for patient-specific finite element models for the assessment of tibia fracture risk in osteogenesis imperfecta.
Lower limb deformation in children with osteogenesis imperfecta (OI) impairs ambulation and may lead to fracture. Corrective surgery is based on empirical assessment criteria. The objective was to develop a reconstruction method of the tibia for OI patients that could be used as input of a comprehensive finite element model to assess fracture risks. Data were obtained from three children with OI and tibia deformities. Four pQCT scans were registered to biplanar radiographs, and a template mesh was deformed to fit the bone outline. Cortical bone thickness was computed. Sensitivity of the model to missing slices of pQCT was assessed by calculating maximal von Mises stress for a vertical hopping load case. Sensitivity of the model to ±5 % of cortical thickness measurements was assessed by calculating loads at fracture. Difference between the mesh contour and bone outline on the radiographs was below 1 mm. Removal of one pQCT slice increased maximal von Mises stress by up to 10 %. Simulated ±5 % variation of cortical bone thickness leads to variations of up to 4.1 % on predicted fracture loads. Using clinically available tibia imaging from children with OI, the developed reconstruction method allowed the building of patient-specific finite element models.
Canada Research Chair in Orthopedic Engineering, Department of Mechanical Engineering, Polytechnique Montréal, P.O. Box 6079, Downtown Station, Montreal, QC, H3C 3A7, Canada.|Sainte-Justine University Hospital Center, Montréal, QC, Canada.|iLab-Spine (International Laboratory - Spine Imaging and Biomechanics), Montreal, QC, Canada.|Canada Research Chair in Mechanobiology of the Pediatric Musculoskeletal System, Department of Mechanical Engineering, Polytechnique Montréal, P.O. Box 6079, Downtown Station, Montreal, QC, H3C 3A7, Canada.
Christiane
C
Caouette
Canada Research Chair in Orthopedic Engineering, Department of Mechanical Engineering, Polytechnique Montréal, P.O. Box 6079, Downtown Station, Montreal, QC, H3C 3A7, Canada.
Nicole
N
Ikin
Sainte-Justine University Hospital Center, Montréal, QC, Canada.|iLab-Spine (International Laboratory - Spine Imaging and Biomechanics), Montreal, QC, Canada.|Canada Research Chair in Mechanobiology of the Pediatric Musculoskeletal System, Department of Mechanical Engineering, Polytechnique Montréal, P.O. Box 6079, Downtown Station, Montreal, QC, H3C 3A7, Canada.
Isabelle
I
Villemure
IFSTTAR, Aix-Marseille University, Marseille, France.|iLab-Spine (International Laboratory - Spine Imaging and Biomechanics), Marseille, France.
Pierre-Jean
PJ
Arnoux
Sainte-Justine University Hospital Center, Montréal, QC, Canada.|Shriners Hospital for Children, Montréal, QC, Canada.|McGill University, Montreal, QC, Canada.
Frank
F
Rauch
Canada Research Chair in Orthopedic Engineering, Department of Mechanical Engineering, Polytechnique Montréal, P.O. Box 6079, Downtown Station, Montreal, QC, H3C 3A7, Canada. carl-eric.aubin@polymtl.ca.|Sainte-Justine University Hospital Center, Montréal, QC, Canada. carl-eric.aubin@polymtl.ca.|iLab-Spine (International Laboratory - Spine Imaging and Biomechanics), Montreal, QC, Canada. carl-eric.aubin@polymtl.ca.
Carl-Éric
CÉ
Aubin
D000293:Adolescent; D002648:Child; D005260:Female; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D008953:Models, Anatomic; D010013:Osteogenesis Imperfecta / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology*; D057285:Precision Medicine / Q000379:methods; D018570:Risk Assessment / Q000379:methods*; D013978:Tibial Fractures / Q000209:etiology*
Finite element modeling; Osteogenesis imperfecta; Patient-specific geometry; Tibia bowing