Relationship between vacA Types and Development of Gastroduodenal Diseases.
The Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted pore-forming toxin and a major virulence factor in the pathogenesis of H. pylori infection. While VacA is present in almost all strains, only some forms are toxigenic and pathogenic. While vacA and its genotypes are considered as markers of H. pylori-related diseases or disorders, the pathophysiological mechanisms of VacA and its genotypes remain controversial. This review outlines key findings of publications regarding vacA with emphasis on the relationship between vacA genotypes and the development of human disease.
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-Machi, Yufu-City, Oita 879-5593, Japan. huyentrang110@yahoo.com.|Department of Molecular Biology, 108 Hospital, Hanoi, Vietnam. huyentrang110@yahoo.com.
Tran
T
Thi Huyen Trang
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-Machi, Yufu-City, Oita 879-5593, Japan. binh79@oita-u.ac.jp.|Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh, Vietnam. binh79@oita-u.ac.jp.
Tran
T
Thanh Binh
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-Machi, Yufu-City, Oita 879-5593, Japan. yyamaoka@oita-u.ac.jp.|Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA. yyamaoka@oita-u.ac.jp.
Yoshio
Y
Yamaoka
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D005838:Genotype; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D010437:Peptic Ulcer / Q000382:microbiology*; D011110:Polymorphism, Genetic; D037521:Virulence Factors
D001426:Bacterial Proteins; C074689:VacA protein, Helicobacter pylori; D037521:Virulence Factors
H. pylori-mediated diseases; VacA genotypes; prolonged Helicobacter pylori infection; vacuolation