Nucleus to Mitochondria: Lost in Transcription, Found in Translation.
Mitochondrial genes reside in the nucleus and mitochondria. In a recent paper in Nature, Couvillion et al. (2016) describe their development of a "mitoribosome profiling" approach and demonstrate that changes in expression of nuclear- and mitochondrial-encoded genes are coordinated at the level of translation during metabolic adaptation to fuel source changes.
Goodman Cancer Research Centre, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada. Electronic address: julie.st-pierre@mcgill.ca.
Julie
J
St-Pierre
Department of Biochemistry, McGill University, Montreal, QC H3A 1A3, Canada; Department of Oncology, McGill University, Montreal, QC H3A 1A3, Canada; Department of Experimental Medicine, McGill University, Montreal, QC H3A 1A3, Canada; Lady Davis Institute, SMBD JGH, McGill University, Montréal, QC H3T 1E2, Canada. Electronic address: ivan.topisirovic@mcgill.ca.
Ivan
I
Topisirovic
D000818:Animals; D005075:Biological Evolution; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D014176:Protein Biosynthesis; D014158:Transcription, Genetic
Mitochondrial biogenesis; Ribosome profiling; mRNA translation