The use of MALDI-MSI in the investigation of psychiatric and neurodegenerative disorders: A review.
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a mass spectrometry technique used for the analysis of macromolecules on an intact tissue of interest, thereby allowing the assessment of molecular signatures in health and disease in the anatomical context. MALDI-MSI is increasingly used to investigate neurodegenerative and psychiatric disorders at the molecular level, including Alzheimer's disease (AD), Parkinson's disease (PD), and schizophrenia (SCZ). These illnesses are characterized by complex neuropathological processes, and conventional proteomic techniques investigating brain tissue homogenates have inherent limitations in determining the precise anatomical or cellular location of proteomic findings. In this article, we review MALDI-MSI studies on neurodegenerative and psychiatric disorders, and explore whether the technique could accelerate the translation of proteomic information into improved understanding and ultimately better therapeutic applications.
Discipline of Psychiatry, The University of Adelaide, Adelaide, Australia.
Klaus Oliver
KO
Schubert
Adelaide Proteomics Centre, The University of Adelaide, Adelaide, Australia.|Institute for Photonics and Advanced Sensing (IPAS), The University of Adelaide, Adelaide, Australia.
Florian
F
Weiland
Discipline of Psychiatry, The University of Adelaide, Adelaide, Australia.
Bernhard T
BT
Baune
Adelaide Proteomics Centre, The University of Adelaide, Adelaide, Australia.|Institute for Photonics and Advanced Sensing (IPAS), The University of Adelaide, Adelaide, Australia.
Peter
P
Hoffmann
D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000473:pathology; D001921:Brain / Q000378:metabolism / Q000473:pathology; D003952:Diagnostic Imaging; D006801:Humans; D019636:Neurodegenerative Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000473:pathology; D011506:Proteins / Q000737:chemistry / Q000302:isolation & purification*; D040901:Proteomics; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000473:pathology; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
D011506:Proteins
Biomedicine; Imaging; MALDI-MSI; Mass spectrometry; Neurodegenerative disorders; Proteomics