Quality of life assessment in female patients 2 and 4 years after muscle-derived cell transplants for stress urinary incontinence treatment.
Regenerative medicine for the treatment of urinary incontinence has become a popular area of focus in the search for therapies for this disease. The paper focused on women's quality of life assessment who were subjected to transplantation of MDSC (autologous muscle derived stem cells) to the urethral sphincter.



The procedure was conducted in 16 female patients who completed the observation stage. Assessment of quality of life before and after the treatment (two and four years post-operation) was conducted based on the validated I-QOL questionnaire (the Polish language version).



The questionnaire study showed that autologous cell therapy significantly improves quality of life in female patients suffering from stress urinary incontinence (SUI). The total I-QOL score increased from 49 (SD ± 7.7) before therapy to 77 (SD ± 5.4) two years post-operation. Four years after the procedure, quality of life remained at a higher level than before therapy, although quality of life decreased by several points when compared with the results from the two-year follow-up - 63 (SD ± 7.2). Patients reported significantly less concern related to their ability to reach the toilet to avoid incontinence, improved sleep at night, a higher level of satisfaction with life, and more satisfaction with their sexual lives (p<0.05).



The MDSC injection procedure for SUI treatment has significant improved quality of life in the majority of our patients in 2 and 4 year follow-up.
ksw@cm-uj.krakow.pl.
Klaudia
K
Stangel-Wojcikiewicz
Monika
M
Piwowar
Robert
R
Jach
Marcin
M
Majka
Antoni
A
Basta
D000328:Adult; D001294:Attitude to Health; D017690:Cell Transplantation / Q000379:methods; D005260:Female; D006304:Health Status; D006801:Humans; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000637:transplantation*; D011788:Quality of Life / Q000523:psychology*; D014550:Urinary Incontinence, Stress / Q000523:psychology* / Q000601:surgery*