Antimicrobial, antibiofilm and antitumor activities of essential oil of Agastache rugosa from Xinjiang, China.
In the study, we evaluated chemical composition and antimicrobial, antibiofilm, and antitumor activities of essential oils from dried leaf essential oil of leaf and flower of Agastache rugosa for the first time. Essential oil of leaf and flower was evaluated with GC and GC-MS methods, and the essential oil of flower revealed the presence of 21 components, whose major compounds were pulegone (34.1%), estragole (29.5%), and p-Menthan-3-one (19.2%). 26 components from essential oil of leaf were identified, the major compounds were p-Menthan-3-one (48.8%) and estragole (20.8%). At the same time, essential oil of leaf, there is a very effective antimicrobial activity with MIC ranging from 9.4 to 42 μg ml(-1) and potential antibiofilm, antitumor activities for essential oils of flower and leaf essential oil of leaf. The study highlighted the diversity in two different parts of A. rugosa grown in Xinjiang region and other places, which have different active constituents. Our results showed that this native plant may be a good candidate for further biological and pharmacological investigations.
The Fifth Affiliated Hospital of Xinjiang Medical University, Xinshi District, No. 118 Henan Westroad, Urumqi, Xinjiang, PR China; Xinjiang Medical University, Xinshi District, No. 393 Xinyi Road, Urumqi, Xinjiang, PR China.
Gong
G
Haiyan
Xinjiang Medical University, Xinshi District, No. 393 Xinyi Road, Urumqi, Xinjiang, PR China.
He
H
Lijuan
The Third Affiliated Hospital of Xinjiang Medical University, Xinshi District, No. 789 Suzhou Eestroad, Urumqi, Xinjiang, PR China.
Li
L
Shaoyu
The Fifth Affiliated Hospital of Xinjiang Medical University, Xinshi District, No. 118 Henan Westroad, Urumqi, Xinjiang, PR China.
Zhang
Z
Chen
Faculty of Science and Natural Resources, University Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia.
Muhammad Aqeel
MA
Ashraf
Agastache rugosa; Biological; China; Essential oil; GC–MS; Pharmacological