Effect of Extreme Wettability on Platelet Adhesion on Metallic Implants: From Superhydrophilicity to Superhydrophobicity.
In order to design antithrombotic implants, the effect of extreme wettability (superhydrophilicity to superhydrophobicity) on the biocompatibility of the metallic substrates (stainless steel and titanium) was investigated. The wettability of the surface was altered by chemical treatments and laser ablation methods. The chemical treatments generated different functionality groups and chemical composition as evident from XPS analysis. The micro/nanopatterning by laser ablation resulted in three different pattern geometry and different surface roughness and consequently wettability. The patterned surface were further modified with chemical treatments to generate a wide range of surface wettability. The influence of chemical functional groups, pattern geometry, and surface wettability on protein adsorption and platelet adhesion was studied. On chemically treated flat surfaces, the type of hydrophilic treatment was shown to be a contributing factor that determines the platelet adhesion, since the hydrophilic oxidized substrates exhibit less platelet adhesion in comparison to the control untreated or acid treated surfaces. Also, the surface morphology, surface roughness, and superhydrophobic character of the surfaces are contributing factors to platelet adhesion on the surface. Our results show that superhydrophobic cauliflower-like patterns are highly resistant to platelet adhesion possibly due to the stability of Cassie-Baxter state for this pattern compared to others. Our results also show that simple surface treatments on metals offer a novel way to improve the hemocompatibility of metallic substrates.
Department of Chemical and Biological Engineering, ‡Centre for Blood Research, Pathology and Laboratory Medicine, Life Science Centre, and §Department of Chemistry, University of British Columbia , Vancouver, British Columbia V6T 1Z3, Canada.
Sona
S
Moradi
Department of Chemical and Biological Engineering, ‡Centre for Blood Research, Pathology and Laboratory Medicine, Life Science Centre, and §Department of Chemistry, University of British Columbia , Vancouver, British Columbia V6T 1Z3, Canada.
Narges
N
Hadjesfandiari
Department of Chemical and Biological Engineering, ‡Centre for Blood Research, Pathology and Laboratory Medicine, Life Science Centre, and §Department of Chemistry, University of British Columbia , Vancouver, British Columbia V6T 1Z3, Canada.
Salma Fallah
SF
Toosi
Department of Chemical and Biological Engineering, ‡Centre for Blood Research, Pathology and Laboratory Medicine, Life Science Centre, and §Department of Chemistry, University of British Columbia , Vancouver, British Columbia V6T 1Z3, Canada.
Jayachandran N
JN
Kizhakkedathu
Department of Chemical and Biological Engineering, ‡Centre for Blood Research, Pathology and Laboratory Medicine, Life Science Centre, and §Department of Chemistry, University of British Columbia , Vancouver, British Columbia V6T 1Z3, Canada.
Savvas G
SG
Hatzikiriakos
D001792:Blood Platelets; D010973:Platelet Adhesiveness; D013499:Surface Properties; D017155:Wettability
blood compatibility; chemical treatment; metallic implants; platelet adhesion; superhydrophobicity; surface modification