Visceral fat obesity increases serum DPP-4 levels in men with type 2 diabetes mellitus.
OBJECTIVE
The relationship between serum DPP-4 level and visceral fat mass is still unclear in type 2 diabetes mellitus (T2DM). This study thus aimed to examine the association of visceral fat accumulation and metabolic syndrome with serum DPP-4 levels in T2DM.


METHODS
Visceral and subcutaneous fat areas were evaluated by performing computed tomography scan in 135 men with T2DM, who had never taken DPP-4 inhibitors or GLP-1 receptor agonists. We investigated the association between serum DPP-4 levels and visceral fat area as well as the presence of metabolic syndrome.


RESULTS
Multiple regression analysis adjusted for age, duration of T2DM, body mass index, serum creatinine, and HbA1c showed that serum DPP-4 levels were positively associated with visceral fat area (β=0.25, p=0.04), but not subcutaneous fat area (β=-0.18, p=0.13). In logistic regression analyses adjusted for the confounding factors described above, serum DPP-4 levels were positively associated with visceral fat obesity and metabolic syndrome [odds ratio (OR)=1.63, 95% confidence interval (CI)=1.00-2.66 per standard deviation (SD) increase, p=0.04; OR=1.77, 95%CI=1.09-2.88 per SD increase, p=0.02, respectively].


CONCLUSIONS
The present study showed that serum DPP-4 level was positively and specifically associated with accumulation of visceral fat and the presence of metabolic syndrome in men with T2DM.
Department of Internal Medicine 1, Shimane University Faculty of Medicine, Japan. Electronic address: s-tanaka@med.shimane-u.ac.jp.
Sayuri
S
Tanaka
Department of Internal Medicine 1, Shimane University Faculty of Medicine, Japan. Electronic address: ippei.k@med.shimane-u.ac.jp.
Ippei
I
Kanazawa
Department of Internal Medicine 1, Shimane University Faculty of Medicine, Japan. Electronic address: mnotsu25@med.shimane-u.ac.jp.
Masakazu
M
Notsu
Department of Internal Medicine 1, Shimane University Faculty of Medicine, Japan. Electronic address: sugimoto@med.shimane-u.ac.jp.
Toshitsugu
T
Sugimoto
D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D018819:Dipeptidyl Peptidase 4 / Q000097:blood*; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging*; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D008875:Middle Aged; D015999:Multivariate Analysis; D056128:Obesity, Abdominal / Q000097:blood* / Q000150:complications; D009929:Organ Size; D050151:Subcutaneous Fat / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4
Dipeptidyl peptidase-4; Metabolic syndrome; Type 2 diabetes mellitus; Visceral fat