NK cells and type 1 innate lymphoid cells: partners in host defense.
Innate lymphoid cells (ILCs) are effectors and regulators of innate immunity and tissue modeling and repair. Researchers have identified subsets of ILCs with differing functional activities, capacities to produce cytokines and transcription factors required for development and function. Natural killer (NK) cells represent the prototypical member of the ILC family. Together with ILC1s, NK cells constitute group 1 ILCs, which are characterized by their capacity to produce interferon-γ and their functional dependence on the transcription factor T-bet. NK cells and ILC1s are developmentally distinct but share so many features that they are difficult to distinguish, particularly under conditions of infection and inflammation. Here we review current knowledge of NK cells and the various ILC1 subsets.
Department of Cell Biology, Academic Medical Center at the University of Amsterdam, Amsterdam, the Netherlands.|Department of Experimental Immunology, Academic Medical Center at the University of Amsterdam, Amsterdam, the Netherlands.
Hergen
H
Spits
Department of Cell Biology, Academic Medical Center at the University of Amsterdam, Amsterdam, the Netherlands.|Department of Experimental Immunology, Academic Medical Center at the University of Amsterdam, Amsterdam, the Netherlands.
Jochem H
JH
Bernink
Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA.
Lewis
0000-0003-1308-3952
L
Lanier
D000818:Animals; D002454:Cell Differentiation; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D007371:Interferon-gamma / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D020825:T-Box Domain Proteins / Q000235:genetics / Q000378:metabolism*; D000098815:T-bet Transcription Factor
D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D007371:Interferon-gamma