Purpura fulminans and severe sepsis due to Pasteurella multocida infection in an immunocompetent patient.
A 75-year-old woman was admitted into the intensive care unit, with severe sepsis and renal failure. She developed purpura fulminans (PF) of bilateral upper and lower extremities along with gangrene on the tips of her fingers and toes. Blood cultures confirmed Pasteurella multocida as the causative organism. Despite aggressive supportive measures, the patient remained dependent on high doses of vasopressors and the gangrene progressed. She ultimately succumbed to her underlying severe sepsis. PF is a rare and fatal dermatological emergency commonly seen in children, but it also occurs in adults. Acute infectious PF occurs secondary to severe sepsis and P. multocida is a rare cause of PF. To the best of our knowledge, this is only the second reported case of PF due to P. multocida in an adult.
Department of Internal Medicine, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA.
Monoj Kumar
MK
Konda
Department of Internal Medicine, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA.
Stephanie
S
Chang
Department of Critical Care, Bronson Methodist Hospital, Kalamazoo, Michigan, USA.
Mathew
M
Zaccheo
D000368:Aged; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007121:Immunocompetence; D010326:Pasteurella Infections / Q000382:microbiology*; D016979:Pasteurella multocida / Q000302:isolation & purification; D055665:Purpura Fulminans / Q000382:microbiology*; D012772:Shock, Septic / Q000382:microbiology*