Giant proliferating pilomatricoma; report of a rare entity.
Proliferating pilomatricoma is a benign tumour and a rare variant of pilomatricoma that has the potential for local recurrence if incompletely excised. We report a case of giant proliferating pilomatricoma on the forearm of a 66-year-old woman. This tumour was unusually large and the presence of ulceration and rapid growth raised clinical suspicion of malignancy. The identification of shadow or ghost cells is a good clue to matrical differentiation, which can be confirmed by β-catenin immunostaining.
Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Perth, Western Australia, Australia.
Robert L
RL
Grohs
Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Perth, Western Australia, Australia.
Nima
N
Mesbah Ardakani
Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Perth, Western Australia, Australia.|School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia.
Nathan T
NT
Harvey
Department of Plastic Surgery, Charles Gairdner Hospital, Perth, Western Australia, Australia.
Bernard P
BP
Luczak
Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Perth, Western Australia, Australia.|School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia.
Benjamin A
BA
Wood
D000368:Aged; D005260:Female; D005542:Forearm; D006201:Hair Diseases / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D018296:Pilomatrixoma / Q000175:diagnosis / Q000473:pathology*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*
matrical keratinisation; proliferating pilomatricoma; shadow/ghost cells; β-catenin