Chemical constituents from the fruiting bodies of Amauroderma subresinosum.
The chemical investigation on the fruiting bodies of Amauroderma subresinosum led to the isolation of 10 compounds including 2 new ones named amaurosubresin (1) and erythro(23,24)-5α,6α-epoxyergosta-8-ene-7-one-3β,23-diol (2). Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy as well as MS. The bioassay of inhibitory activity against acetylcholinesterase (AChE) of two new isolates exhibited definite inhibitory activity.
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , China.|b Food Science and Technology College , Huazhong Agricultural University , Wuhan 430070 , China.
Qiao
Q
Wang
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , China.
Yu-Guang
YG
Wang
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , China.
Qing-Yun
QY
Ma
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , China.
Sheng-Zhuo
SZ
Huang
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , China.
Fan-Dong
FD
Kong
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , China.
Li-Man
LM
Zhou
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , China.
Hao-Fu
HF
Dai
a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology , Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , China.
You-Xing
YX
Zhao
D000110:Acetylcholinesterase / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006873:Hydroquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D020072:Polyporales / Q000737:chemistry*
D002800:Cholinesterase Inhibitors; D006873:Hydroquinones; C000613637:amaurosubresin; C000613638:erythro(23,24)-5alpha,6alpha-epoxyergosta-8-ene-7-one-3beta,23-diol; D000110:Acetylcholinesterase; D004875:Ergosterol
AChE inhibitory activity; Amauroderma subresinosum; Ganodermataceae; amaurosubresin; ergosta