The complexity of life and death decisions in mitosis.
The anticancer drug taxol stabilizes microtubules and activates the spindle checkpoint, causing prolonged mitotic arrest in cancer cells. Our recent work suggests that the cellular decision to live or die following mitotic arrest is a complex process involving crosstalk between competing apoptotic and adaptation pathways.
Howard Hughes Medical Institute; Department of Pharmacology ; University of Texas Southwestern Medical Center ; Dallas, TX USA.
Laura A
LA
Diaz-Martinez
Howard Hughes Medical Institute; Department of Pharmacology ; University of Texas Southwestern Medical Center ; Dallas, TX USA.
Hongtao
H
Yu
apoptosis; cell death; mitochondrial fusion; mitosis; taxol