Model organoids provide new research opportunities for ductal pancreatic cancer.
We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.
Hubrecht Institute; Royal Netherlands Academy of Arts and Sciences (KNAW); University Medical Center Utrecht and Cancer Genomics; Utrecht, the Netherlands; Foundation Hubrecht Organoid Technology; Utrecht, the Netherlands.
Sylvia F
SF
Boj
Cold Spring Harbor Laboratory; Cold Spring Harbor, NY USA; Lustgarten Foundation Pancreatic Cancer Research Laboratory; Cold Spring Harbor, NY USA.
Chang-Il
CI
Hwang
Cold Spring Harbor Laboratory; Cold Spring Harbor, NY USA; Lustgarten Foundation Pancreatic Cancer Research Laboratory; Cold Spring Harbor, NY USA.
Lindsey A
LA
Baker
Cold Spring Harbor Laboratory; Cold Spring Harbor, NY USA; Lustgarten Foundation Pancreatic Cancer Research Laboratory; Cold Spring Harbor, NY USA.
Dannielle D
DD
Engle
Cold Spring Harbor Laboratory; Cold Spring Harbor, NY USA; Lustgarten Foundation Pancreatic Cancer Research Laboratory; Cold Spring Harbor, NY USA; Rubenstein Center for Pancreatic Cancer Research; Memorial Sloan Kettering Cancer Center; New York, NY USA.
David A
DA
Tuveson
Hubrecht Institute; Royal Netherlands Academy of Arts and Sciences (KNAW); University Medical Center Utrecht and Cancer Genomics ; Utrecht, the Netherlands.
Hans
H
Clevers
cancer; organoids; pancreatic ductal adenocarcinoma; preclinical models