Synthesis of Bestatin, a Potent Inhibitor of Leukotriene A4 Hydrolase, by an N3 Nucleophile Reaction to a Non-protected Diol.
The synthesis of bestatin (1), based on the regio-selective introduction of a nitrogen function to a non-protected diol 9, is described.
a Japan Tobacco Inc. , Life Science Research Laboratory , 6-2 Umegaoka, Aoba-ku, Yokohama, Kanagawa 227 , Japan.
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Koseki
a Japan Tobacco Inc. , Life Science Research Laboratory , 6-2 Umegaoka, Aoba-ku, Yokohama, Kanagawa 227 , Japan.
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Ebata
a Japan Tobacco Inc. , Life Science Research Laboratory , 6-2 Umegaoka, Aoba-ku, Yokohama, Kanagawa 227 , Japan.
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Matsushita
azidc introduction; bestatin; synthesis