Blood morphology and the levels of selected cytokines related to hematopoiesis in occupational short-term exposure to lead.
The aim of the study was to investigate the influence of a short-term exposure to lead on the blood morphology and the levels of selected cytokines related to hematopoiesis in occupationally exposed workers. The study population included 37 males occupationally exposed to lead for 36 to 44days. Their blood lead level raised from 10.7±7.67μg/dl at baseline to the level of 49.1±14.1μg/dl at the end of the study. The level of hemoglobin and values of MCH and MCHC were decreased due to a short-term exposure to lead by 2%, 2%, and 1%, respectively. The counts of WBC, LYM, and MXD increased significantly by 5%, 7%, and 35%. Similarly, the count of PLT increased by 7%, while PDW, MPV, and P-LCR decreased by 6%, 3%, and 9%, respectively. The levels of IL-7, G-CSF, HGF, PDGF AB/BB, SCF, and PECAM-1, decreased significantly by 30%, 33%, 8%, 30%, 25%, and 20%, respectively. A short-term occupational exposure to lead results in a decreased hemoglobin level and increased counts of WBC and PLT. Changes in counts and proportions of different types of leukocytes and decreased values of PLT indices, such as PDW, MPV, and P-LCR, due to the subacute lead-exposure may be associated with lead-induced decreased levels of cytokines related to hematopoiesis, including SCF, G-CSF, IL-7, and PDGF.
Department of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze, Poland. Electronic address: michal.dobrakowski@poczta.fm.
Michał
M
Dobrakowski
Institute of Occupational Medicine and Environmental Health in Sosnowiec, ul. Kościelna 13, 41-200 Sosnowiec, Poland.
Marta
M
Boroń
Department of Microbiology and Immunology, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze, Poland.
Zenon P
ZP
Czuba
Department of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze, Poland.
Ewa
E
Birkner
SP ZOZ Municipal Hospital, Department of Internal Medicine, ul. Strzelców Bytomskich 11, 41-500 Chorzów, Poland.
Artur
A
Chwalba
Department of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze, Poland.
Edyta
E
Hudziec
Department of Biochemistry, School of Medicine with the Division of Dentistry, Medical University of Silesia, ul. Jordana 19, 41-808 Zabrze, Poland.
Sławomir
S
Kasperczyk
D000328:Adult; D000395:Air Pollutants, Occupational / Q000097:blood*; D001792:Blood Platelets / Q000187:drug effects; D016207:Cytokines / Q000097:blood*; D006403:Hematologic Tests; D006410:Hematopoiesis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007854:Lead / Q000097:blood*; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure
D000395:Air Pollutants, Occupational; D016207:Cytokines; D006454:Hemoglobins; D007854:Lead
Blood morphology; Cytokines; Hematopoiesis; Subacute exposure to lead