Effect of taxol on the expression ofFoxM1ovarian cancer-associated gene.
The incidence of ovarian cancer in women has been on the increase in recent years. The aim of the present study was to examine the effects of taxol on the expression of ovarian cancer-associated gene forkhead box transcription factor M1 (FoxM1)and its therapeutic effects for ovarian cancer. The expression ofFoxM1gene was examined in patients with or without ovarian cancer. RNA and protein levels ofFoxM1gene of ovarian cancer patients were detected at different time periods (1, 3, 6, 8, 12 and 24 months) after treatment with taxol. The results showed that the mRNA level ofFoxM1gene in patients with ovarian cancer was significantly higher than that in normal women (P<0.05). With time and progression of the disease, the expression ofFoxM1gene significantly increased in the patients not being administered taxol, whereas the expression ofFoxM1in the patients administered taxol was significantly lower comparatively (P<0.05). In conclusion, an asssociation was identified between theFoxM1gene and ovarian cancer. TheFoxM1gene therefore promotes the generation and deterioration of ovarian cancer, whereas taxol reduces it. These findings provide a certain theoretical basis for the later treatment of ovarian cancer disease.
Department of Nuclear Medicine, Central Hospital of Xiangyang, Xiangyang, Hubei 441021, P.R. China.
Zeng
Z
Liu
State Drug Clinical Trial Agency, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Science, Chengdu, Sichuan 610072, P.R. China.
Y U
YU
Xiao
Department of Nuclear Medicine, Central Hospital of Xiangyang, Xiangyang, Hubei 441021, P.R. China.
Siqing
S
Ning
Department of Nuclear Medicine, Central Hospital of Xiangyang, Xiangyang, Hubei 441021, P.R. China.
Zhao Yuan
ZY
Li
Department of Nuclear Medicine, Xiangyang No. 1 People's Hospital, Xiangyang, Hubei 441000, P.R. China.
Yuanyuan
Y
Zhu
Department of Breast Surgery, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Science, Chengdu, Sichuan 610072, P.R. China.
Gang
G
Hu
FoxM1; RT-polymerase chain reaction; interrelation; ovarian cancer; western blotting