A Case of Acantholytic Squamous Cell Carcinoma.
Acantholytic squamous cell carcinoma is a well-defined variant of squamous cell cancer in which significant portions of the neoplastic proliferation show a pseudoglandular or tubular microscopic pattern. It usually presents as a nodule with various colors, and it is accompanied by scaling, crusting, and ulceration on the sun-exposed areas of older aged individuals. Histologically, the tumor consists of a nodular, epidermal-derived proliferation that forms island-like structures. At least focally or sometimes extensively, the tumor cells shows a loss of cohesion within the central gland-like or tubular spaces. This tumor resembles the structure of eccrine neoplasms, but it is negative for dPAS, CEA and mucicarmine and it is only positive for EMA and cytokeratins. Herein we report a case of acantholytic squamous cell carcinoma that occurred on the face of an 82-year-old woman.
Department of Dermatology, School of Medicine, Ewha Womans University, Seoul, Korea.
Ji Yeon
JY
Lim
Department of Dermatology, School of Medicine, Ewha Womans University, Seoul, Korea.
Mi Ok
MO
Do
Department of Dermatology, Ilsan Paik Hospital, Inje University School of Medicine, Goyang, Korea.
Seong Hyun
SH
Kim
Department of Dermatology, Seoul Paik Hospital, Inje University School of Medicine, Seoul, Korea.
Jeong Hee
JH
Hahm
Serion Dermatology Clinic, Seoul, Korea.
Kyu Kwang
KK
Whang
Acantholytic; Adenoid; SCC; Skin