Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs.
The influence of nanoparticle (NP) formulations on the pharmacokinetic, pharmacodynamic and biodistribution profiles of peptide- and protein-like drugs following oral administration is critically reviewed. The possible mechanisms of absorption enhancement and the effects of the physicochemical properties of the NP are examined. The potential advantages and challenges of physiologically-based pharmacokinetic (PBPK) modelling to help predict efficacy in man are discussed. The importance of developing and expanding the regulatory framework to help translate the technology into the clinic and accelerate the availability of oral nanoparticulate formulations is emphasized. In conclusion, opportunities for future work to improve the state of the art of oral nanomedicines are identified.
School of Pharmacy, University College Cork, Cavanagh Pharmacy Building, Cork, Ireland.
Brendan T
BT
Griffin
School of Pharmacy, University College Cork, Cavanagh Pharmacy Building, Cork, Ireland.
Jianfeng
J
Guo
School of Pharmacy, University College Cork, Cavanagh Pharmacy Building, Cork, Ireland.
Elena
E
Presas
School of Pharmacy, University College Cork, Cavanagh Pharmacy Building, Cork, Ireland.
Maria D
MD
Donovan
CIMUS Research Institute, University of Santiago de Compostela, Santiago de Compostela, Spain.
María J
MJ
Alonso
School of Pharmacy, University College Cork, Cavanagh Pharmacy Building, Cork, Ireland. Electronic address: caitriona.odriscoll@ucc.ie.
Caitriona M
CM
O'Driscoll
D000284:Administration, Oral; D000818:Animals; D004337:Drug Carriers / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000378:metabolism; D010455:Peptides / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D011506:Proteins / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D004337:Drug Carriers; D010455:Peptides; D004364:Pharmaceutical Preparations; D011506:Proteins
Bioavailability; Nanoparticles for oral administration; Pharmacokinetics and pharmacodynamics of peptide and protein drugs; Physiologically-based pharmacokinetic modelling; Regulatory challenges