A New Role for Glia in Leptin Action and Energy Balance.
Chemo- or radiotherapy against dividing cells in the brain can promote obesity. Djogo et al. (2016) suggest that the loss of NG2 glia and diminished leptin action in the median eminence underlie this response, likely due to the loss of dendrites originating in the adjacent arcuate nucleus.
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA; Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48105, USA.
Warren
W
Pan
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA; Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48105, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA. Electronic address: mgmyers@umich.edu.
Martin G
MG
Myers
D000818:Animals; D004734:Energy Metabolism; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D009457:Neuroglia / Q000378:metabolism*
D020738:Leptin