Analysis of circulatory mitochondrial DNA level after cardiac surgery with cardiopulmonary bypass and potential prognostic implications.
Our research letter found that circulatory mtDNA level increased after the end of CPB and positive correlations between mtDNA and peak CRP level, peak BNP level, and peak PCT level, which revealed the prognostic role of perioperative circulatory mtDNA level in patients who underwent cardiopulmonary bypass.
Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Chaoyi
C
Qin
Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Jun
J
Gu
Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Hong
H
Qian
Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, PR China. Electronic address: meng_wei_1111@yahoo.com.
Wei
W
Meng
D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002315:Cardiopulmonary Bypass; D004272:DNA, Mitochondrial / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000097:blood / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood*; D011184:Postoperative Period; D011379:Prognosis; D012189:Retrospective Studies
D015415:Biomarkers; D004272:DNA, Mitochondrial; D002097:C-Reactive Protein
Cardiopulmonary bypass; Mitochondrial DNA; Prognostic predictor