Time-dependent Changes of Atherosclerotic LDL Complexes after Smoking Cessation.
OBJECTIVE
The α1-antitrypsin-low-density lipoprotein complex (AT-LDL) and serum amyloid A-LDL complex (SAA-LDL) are oxidatively modified LDL complexes that promote atherosclerosis. The serum levels of AT-LDL and SAA-LDL are suggested to be increased by obesity and smoking. We have previously demonstrated that larger weight gain after smoking cessation (SC) perturbs a decrease in the serum level of AT-LDL at 3 months after SC. However, changes of these atherosclerotic makers ＞3 months after SC are unknown. This study investigated post-SC time-dependent changes in two atherogenic lipoproteins, AT-LDL and SAA-LDL, and in the extent of abdominal obesity.


METHODS
In 50 outpatients who had continued SC for 1 year, we measured serum AT-LDL and SAA-LDL levels by the enzyme-linked immunosorbent assay before SC, and at 3 months and 1 year after SC.


RESULTS
Both body mass index and waist circumstance significantly increased from pre-SC to 3 months after SC and from 3 months after SC to 1 year after SC. Although the serum levels of AT-LDL and SAA-LDL were unchanged from pre-SC to 3 months after SC, these levels decreased significantly from 3 months after SC to 1 year after SC.


CONCLUSIONS
The extent of abdominal obesity and levels of two atherogenic lipoproteins time-dependently change after SC. Although abdominal obesity progressively worsened after SC, the beneficial effect of non-smoking overcomes the potential vascular risks by cessation-associated obesity at 1 year after SC.
Clinical Research Institute, National Hospital Organization Kyoto Medical Center.
Maki
M
Komiyama
Sayaka
S
Shimada
Hiromichi
H
Wada
Hajime
H
Yamakage
Noriko
N
Satoh-Asahara
Akira
A
Shimatsu
Masaharu
M
Akao
Tatsuya
T
Morimoto
Yuko
Y
Takahashi
Koji
K
Hasegawa
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology; D011379:Prognosis; D011446:Prospective Studies; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D016540:Smoking Cessation; D013997:Time Factors; D015430:Weight Gain; D000515:alpha 1-Antitrypsin / Q000097:blood*
D015415:Biomarkers; D008077:Lipoproteins, LDL; D000685:Serum Amyloid A Protein; D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein