[Citrullination and rheumatoid arthritis].
Anti-citrullinated peptide antibody (ACPA) is detected in rheumatoid arthritis (RA)patients, and its clinical importance is established for RA diagnosis and as a prognosis marker. ACPA itself plays some roles in RA pathogenesis, such as promoting osteoclastogenesis. Citrullinated epitope-specific T cells also play an important role in RA pathogenesis and a recent study showed the clinical efficacy of tolerance induction of citrullinated epitopes for RA. As a source of citrullinated antigens, neutrophil extracellular traps (NETs)are supposed, because NETs contain a plenty of citrullinated histones. Peptidylarginine deiminase (PADI) 4 is one of the RA risk genes and associated with protein citrullinations. PADI4 plays a pivotal role in NETosis. And, we recently demonstrated its importance in arthritis by analyzing PADI4-deficient mice.
Hirofumi
H
Shoda
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000209:etiology*; D001323:Autoantibodies / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000235:genetics / Q000276:immunology; D065206:Extracellular Traps / Q000235:genetics / Q000276:immunology; D006657:Histones; D006801:Humans; D006867:Hydrolases / Q000502:physiology; D051379:Mice; D010456:Peptides, Cyclic / Q000276:immunology*; D000080002:Protein-Arginine Deiminase Type 4; D000076342:Protein-Arginine Deiminases; D013601:T-Lymphocytes / Q000276:immunology
D001323:Autoantibodies; D018984:Epitopes, T-Lymphocyte; D006657:Histones; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D006867:Hydrolases; C000629235:PADI4 protein, human; D000080002:Protein-Arginine Deiminase Type 4; D000076342:Protein-Arginine Deiminases; C552151:peptidylarginine deiminase 4, mouse