Reassessing the role of NAD as a prosurvival factor.
The mechanisms regulating the choice of cell demise remain largely unknown. NAD(+), a key metabolite with well-known roles in cell metabolism, has been shown to counteract apoptosis while promoting necroptosis, a form of proinflammatory cell death. This observation identifies NAD(+) availability as an important parameter with contrasting roles in the regulation of distinct regulated cell death programs.
Laboratory of Immunobiology, Department of Molecular Biology, Université Libre de Bruxelles , Gosselies, Belgium.
Nicolas
N
Preyat
Laboratory of Immunobiology, Department of Molecular Biology, Université Libre de Bruxelles , Gosselies, Belgium.
Oberdan
O
Leo
Apoptosis; NAD; NAMPT; necroptosis; parthanatos; regulated cell death