RUNX3 defines disease behavior in pancreatic ductal adenocarcinoma.
Runt-related transcription factor 3 (RUNX3) functions downstream of transforming growth factor beta (TGFβ) and plays dual roles in pancreas cancer by both suppressing (by inhibiting proliferation) and promoting (by enhancing migratory and metastatic capacity) disease progression. Consideration of the contextual regulation of RUNX3 together with its myriad downstream effects may help improve clinical outcomes for pancreas cancer patients.
Clinical Research Division , Seattle, WA.
Martin C
MC
Whittle
Clinical Research Division, Seattle, WA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Division of Medical Oncology, University of Washington School of Medicine, Seattle, WA.
Sunil R
SR
Hingorani
Metastasis; RUNX3; SMAD4; TGFβ; pancreatic ductal carcinoma