HIF-1 suppresses lipid catabolism to promote cancer progression.
Hypoxia-inducible factor 1 (HIF-1) promotes glycolysis in cancer cells, hence sustaining survival. We recently reported that HIF-1 suppresses fatty acid β-oxidation in malignant cells through medium- and long-chain acyl-CoA dehydrogenases. This promotes tumor progression by controlling the level of reactive oxygen species and via crosstalk between metabolism and PTEN signaling.
CAS Key Laboratory of Innate Immunity and Chronic Disease; School of Life Sciences ; University of Science and Technology of China ; Hefei, China.
Huafeng
H
Zhang
HIF-1; PTEN; fatty acid catabolism