[Vestibular disorders and nausea during head and neck intensity-modulated radiation therapy].
OBJECTIVE
We studied whether there is a relationship between nausea and vestibular disorders in patients treated with intensity modulated radiation therapy (IMRT) for head and neck cancer.


METHODS
We performed a prospective single-centre study that enrolled 31 patients. A videonystagmography was carried out before and within 15 days after radiation therapy for each patient. Nausea was assessed at baseline, every week, and at the post-radiotherapy videonystagmography visit.


RESULTS
Twenty-six patients had benefited from a complete interpretable videonystagmography. For 14 of these patients vestibular damage was diagnosed post-radiotherapy. During irradiation, six patients felt nauseous, but without dizziness. In univariate analysis, we found a relationship statistically significant between the average dose received by the vestibules and vestibular disorder videonystagmography (P=0.001, odds ratio [OR]: 1.08 [1.025-.138]), but there was no relationship between vestibular disorder videonystagmography and nausea (P=0.701).


CONCLUSIONS
Irradiation of the vestibular system during IMRT does not seem to explain the nausea.
Clinique universitaire d'ORL, pôle TCCR, CHU de Grenoble, 38043 Grenoble cedex 09, France. Electronic address: eberta@chu-grenoble.fr.
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Berta
Clinique universitaire d'ORL, pôle TCCR, CHU de Grenoble, 38043 Grenoble cedex 09, France; Faculté de médecine, université Grenoble-Alpes, 38700 Tronche, France; Inserm U823, domaine de la Merci, 38706 La Tronche cedex, France; Institut Albert-Bonniot, domaine de la Merci, 38706 La Tronche cedex, France.
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Righini
Unité d'épidémiologie et biostatistiques (UEB), département de recherche clinique et innovation et statistiques (Dris), centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex 2, France.
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Chamorey
Clinique universitaire de radiothérapie, CHU de Grenoble, 38043 Grenoble cedex 09, France.
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Villa
Clinique universitaire d'ORL, pôle TCCR, CHU de Grenoble, 38043 Grenoble cedex 09, France; Faculté de médecine, université Grenoble-Alpes, 38700 Tronche, France; Inserm U823, domaine de la Merci, 38706 La Tronche cedex, France; Institut Albert-Bonniot, domaine de la Merci, 38706 La Tronche cedex, France.
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Atallah
Clinique universitaire d'ORL, pôle TCCR, CHU de Grenoble, 38043 Grenoble cedex 09, France; Faculté de médecine, université Grenoble-Alpes, 38700 Tronche, France.
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Reyt
Clinique universitaire d'ORL, pôle TCCR, CHU de Grenoble, 38043 Grenoble cedex 09, France.
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Coffre
Clinique universitaire d'ORL, pôle TCCR, CHU de Grenoble, 38043 Grenoble cedex 09, France; Faculté de médecine, université Grenoble-Alpes, 38700 Tronche, France; Clinatec-CEA, 38700 Grenoble, France.
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Schmerber
D004244:Dizziness / Q000209:etiology*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000209:etiology*; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects*; D012665:Semicircular Canals / Q000528:radiation effects; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000528:radiation effects; D014741:Video Recording
Cancer de la tête et du cou; Dizziness; Head and neck cancer; Intensity-modulated radiation therapy; Nausea; Nausée; Radiothérapie conformationnelle avec modulation d’intensité; Vertige; Vestibule