Optimal Magnetic Field for Crossing Super-Para-Magnetic Nanoparticles through the Brain Blood Barrier: A Computational Approach.
This paper scrutinizes the magnetic field effect to deliver the superparamagnetic nanoparticles (SPMNs) through the Blood Brain Barrier (BBB). Herein we study the interaction between the nanoparticle (NP) and BBB membrane using Molecular Dynamic (MD) techniques. The MD model is used to enhance our understanding of the dynamic behavior of SPMNs crossing the endothelial cells in the presence of a gradient magnetic field. Actuation of NPs under weak magnetic field offers the great advantage of a non-invasive drug delivery without the risk of causing injury to the brain. Furthermore, a weak magnetic portable stimulator can be developed using low complexity prototyping techniques. Based on MD simulation results in this paper, SPMNs can cross the cell membrane while experiencing very weak mechanical forces in the range of pN. This study also derives guidelines for the design of the SPMNs dedicated to crossing the BBB using external magnetic fields.
Department of Mechanical Engineering, Sharif University of Technology, Tehran, PO Box: 11365-11155, Iran. maysam.pedram@gmail.com.
Maysam Z
MZ
Pedram
Department of Mechanical Engineering, Sharif University of Technology, Tehran, PO Box: 11365-11155, Iran. shamloo@sharif.edu.
Amir
A
Shamloo
Department of Mechanical Engineering, Sharif University of Technology, Tehran, PO Box: 11365-11155, Iran. aalasti@sharif.edu.
Aria
A
Alasty
Department of Electrical Engineering, York University, Toronto, ON M3J1P3, Canada. egz@cse.yorku.ca.
Ebrahim
E
Ghafar-Zadeh
D000465:Algorithms; D001812:Blood-Brain Barrier / Q000378:metabolism; D016503:Drug Delivery Systems; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry; D008962:Models, Theoretical; D056004:Molecular Dynamics Simulation; D010539:Permeability; D057900:Transcytosis
D058185:Magnetite Nanoparticles
Blood Brain Barrier; Molecular Dynamics simulation; force steering; superparamagnetic nanoparticles