A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma.
We performed an observational pilot study of 18F-FLT PET/CT in pediatric lymphoma. Eight patients with equivocal 18F-FDG PET/CT underwent imaging with 18F-FLT PET/CT. No immediate adverse reactions to 18F-FLT were observed. Compared to 18F-FDG, 18F-FLT uptake was significantly higher in bone marrow and liver (18F-FLT SUV 8.6 ± 0.6 and 5.0 ± 0.3, versus 18F-FDG SUV 1.9 ± 0.1 and 3.4 ± 0.7, resp., p < 0.05). In total, 15 lesions were evaluated with average 18F-FDG and 18F-FLT SUVs of 2.6 ± 0.1 and 2.0 ± 0.4, respectively. Nonspecific uptake in reactive lymph nodes and thymus was observed. Future studies to assess the clinical utility of 18F-FLT PET/CT in pediatric lymphoma are planned.
Department of Medical Imaging, University of Toronto, 263 McCaul Street, 4th Floor, Toronto, ON, Canada M5T 1W7; Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8.
Danny L
DL
Costantini
Department of Medical Imaging, University of Toronto, 263 McCaul Street, 4th Floor, Toronto, ON, Canada M5T 1W7; Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8.
Reza
R
Vali
Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8.
Susan
S
McQuattie
Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8.
Jeffrey
J
Chan
Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8.
Angela
A
Punnett
Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8.
Shiela
S
Weitzman
Department of Medical Imaging, University of Toronto, 263 McCaul Street, 4th Floor, Toronto, ON, Canada M5T 1W7; Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8.
Amer
A
Shammas
Department of Medical Imaging, University of Toronto, 263 McCaul Street, 4th Floor, Toronto, ON, Canada M5T 1W7; Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8.
Martin
M
Charron