Two new sesquiterpenes from the fruits of Fissistigma villosissimum.
Two new sesquiterpenes, namely fissistinone (1) and fissistinol (2), along with ten known compounds (3-12), were isolated from the fruits of Fissistigma villosissimum. Their structures were elucidated on the basis of spectral data analysis, including one-dimensional (1D), two-dimensional (2D)-nuclear magnetic resonance (NMR), and high-resolution-electrospray ionization-mass spectrometry (HR-ESI-MS). Compounds 1-8 were evaluated for their cytotoxic activities against KB cell line; however, all these compounds did not show cytotoxic activity.
a Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry , Vietnam Academy of Science and Technology (VAST) , Hanoi 844 , Vietnam.|c Faculty of Technology , Industrial University of Vinh , Vinh , Vietnam.
Dang Thach
DT
Tran
a Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry , Vietnam Academy of Science and Technology (VAST) , Hanoi 844 , Vietnam.
Huong Doan Thi
HD
Mai
a Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry , Vietnam Academy of Science and Technology (VAST) , Hanoi 844 , Vietnam.
Huu Giap
HG
Tran
a Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry , Vietnam Academy of Science and Technology (VAST) , Hanoi 844 , Vietnam.
Bich Ngan
BN
Truong
b Département de Chimie des Substances Naturelles et Chimie Médicinale , Institut de Chimie des Substances Naturelles , Gif-sur-Yvette Cedex 91190 , France.
Marc
M
Litaudon
a Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry , Vietnam Academy of Science and Technology (VAST) , Hanoi 844 , Vietnam.
Van Hung
VH
Nguyen
a Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry , Vietnam Academy of Science and Technology (VAST) , Hanoi 844 , Vietnam.
Van Minh
VM
Chau
a Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry , Vietnam Academy of Science and Technology (VAST) , Hanoi 844 , Vietnam.
Cuong Pham
CP
Van
D029061:Annonaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
D012717:Sesquiterpenes; C000616192:fissistinol; C000616191:fissistinone
Annonaceae; Fissistigma villosissimum; cytotoxic activity; sesquiterpene