Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer.
Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/+ heterozygous cells, or Rp/+ heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.
Department of Genetics; Albert Einstein College of Medicine; Bronx, NY USA; Department of Developmental and Molecular Biology; Albert Einstein College of Medicine; Bronx, NY USA; Department of Ophthalmology and Visual Science; Albert Einstein College of Medicine; Bronx, NY USA.
Nicholas E
NE
Baker
Department of Genetics; Albert Einstein College of Medicine ; Bronx, NY USA.
Abhijit
A
Kale
Drosophila melanogaster; apoptosis; cancer predisposition; genetic mosaic; ribosomal protein; somatic mutation