Assessment of Adequacy of Supplementation of Vitamin D in Very Low Birth Weight Preterm Neonates: A Randomized Controlled Trial.
To compare the effect of 400 IU and 1000 IU vitamin D for 6 weeks in very low birth weight preterm neonates.



Randomized, double-blinded controlled trial in a teaching hospital.



Fifty very low birth weight preterm neonates.



Vitamin D 400 IU/day (Group 1) or 1000 IU/day (Group 2).



Change in serum calcium, phosphate, alkaline phosphatase (ALP), 25-hydroxy vitamin D (25-OHD), parathormone, incidence of skeletal hypomineralization and growth.



After 6 weeks of supplementation, the mean serum calcium and 25-OHD levels were significantly higher (p  <  0.001 each), while ALP and parathormone levels significantly lower (p  <  0.001 each) in group 2. Skeletal hypomineralization was lesser and growth better in group 2.



Vitamin D supplementation in a dose of 1000 IU/day is more effective in maintaining serum calcium, phosphate, ALP, 25-OHD and parathormone levels with lower incidence of skeletal hypomineralization and better growth.
Department of Neonatology, Pediatrics and Biochemistry, Maulana Azad Medical College, New Delhi 110002, India drnbmathur@gmail.com.|Department of Neonatology, Maulana Azad Medical College, New Delhi 110002, India.
N B
NB
Mathur
Department of Pediatrics, Maulana Azad Medical College, New Delhi 110002, India.
Ashish
A
Saini
Department of Biochemistry, Maulana Azad Medical College, New Delhi 110002, India.
T K
TK
Mishra
D000469:Alkaline Phosphatase / Q000097:blood; D002112:Calcifediol / Q000097:blood; D002118:Calcium / Q000097:blood; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood; D007235:Infant, Premature, Diseases / Q000097:blood* / Q000453:epidemiology; D019102:Infant, Very Low Birth Weight; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D015995:Prevalence; D014807:Vitamin D / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology; D014815:Vitamins / Q000008:administration & dosage*
D010281:Parathyroid Hormone; D010710:Phosphates; D014815:Vitamins; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D000469:Alkaline Phosphatase; D002112:Calcifediol; D002118:Calcium
preterm; secondary hyperparathyroidism; skeletal mineralization; vitamin D supplementation