Epidermal growth factor, growth differentiation factor-15, and survivin as novel biocompatibility markers in children on chronic dialysis.
BACKGROUND
Chronic dialysis results in aggravation of apoptosis and cell damage, triggered by bioincompatibility of dialysis membranes and peritoneal fluids.


OBJECTIVE
The aim of study was to assess the usefulness of epidermal growth factor (EGF), growth differentiation factor (GDF)-15, and survivin as novel markers of biocompatibility in dialyzed children.


METHODS
Parameters were assessed by ELISA in 19 patients on hemodialysis and 22 children on peritoneal dialysis.


RESULTS
Serum concentrations of analyzed parameters in children on chronic dialysis differed significantly from controls and depended strongly on the dialysis technique.


CONCLUSIONS
EGF, GDF-15, and survivin may serve as new biocompatibility markers in children on chronic dialysis.
a Department of Pediatric Nephrology , Wrocław Medical University , Wrocław , Poland.
Agnieszka
A
Bargenda
a Department of Pediatric Nephrology , Wrocław Medical University , Wrocław , Poland.
Kinga
K
Musiał
a Department of Pediatric Nephrology , Wrocław Medical University , Wrocław , Poland.
Danuta
D
Zwolińska
Apoptosis; chronic kidney disease; growth factors