Prognostic values of B7-H4 in non-small cell lung cancer.
OBJECTIVE
The aim of this study was to explore the prognostic value of serum soluble B7-H4 (sB7-H4) levels in patients with non-small cell lung cancer (NSCLC).


METHODS
Serum specimens from 316 NSCLC patients and 240 healthy controls were collected. The concentrations of sB7-H4 were measured by ELISA.


RESULTS
The levels of sB7-H4 in NSCLC patients were significantly higher than that of the controls (P<0.01). Multivariate survival analysis indicated that sB7-H4 was an independent prognostic indicator of overall survival and progression-free survival (P<0.01).


CONCLUSIONS
Measurement of serum sB7-H4 might be a useful prognostic biomarker for NSCLC.
a Endoscopic Center of Nanjing Chest Hospital , Nanjing , Jiangsu 210029 , China.|b Clinical Center of Nanjing Respiratory Diseases and Imaging , Nanjing , Jiangsu 210029 , China.
Wei
W
Wang
a Endoscopic Center of Nanjing Chest Hospital , Nanjing , Jiangsu 210029 , China.|b Clinical Center of Nanjing Respiratory Diseases and Imaging , Nanjing , Jiangsu 210029 , China.
Chunhua
C
Xu
a Endoscopic Center of Nanjing Chest Hospital , Nanjing , Jiangsu 210029 , China.|b Clinical Center of Nanjing Respiratory Diseases and Imaging , Nanjing , Jiangsu 210029 , China.
Yuchao
Y
Wang
a Endoscopic Center of Nanjing Chest Hospital , Nanjing , Jiangsu 210029 , China.|b Clinical Center of Nanjing Respiratory Diseases and Imaging , Nanjing , Jiangsu 210029 , China.
Like
L
Yu
c Department of Respiratory Medicine , Nanjing Jiangning Hospital , Nanjing , Jiangsu 211100 , China.
Xiuwei
X
Zhang
Soluble B7-H4; biomarker; non-small cell lung cancer; prognosis; serum