Mechanistic insights into the role of truncating PREX2 mutations in melanoma.
PREX2 is a PTEN binding protein that is significantly mutated in melanoma and pancreatic ductal adenocarcinoma. We recently reported the molecular mechanism of tumorigenesis associated with PREX2 mutations: truncating PREX2 mutations activate its RAC1 guanine nucleotide exchanger activity leading to increased PI3K/AKT signaling and enhanced cell proliferation.
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center , Houston, Texas, USA.
Yonathan
Y
Lissanu Deribe
Epigenetics; Melanoma; Mouse models of cancer; PI3K; PREX2; RAC1