PKCλ/ι signaling-a common node for normal cellular development and breast oncogenesis.
We recently demonstrated that PKCλ/ι signaling is an important contributor to breast cancer development. Strikingly, PKCλ/ι signaling is also important to balance self-renewal versus differentiation in pluripotent stem cells and is essential for embryonic development. This commentary highlights some key functions of PKCλ/ι signaling that are integral to both normal development and cancer progression.
The University of Kansas Cancer Center; University of Kansas Medical Center; Kansas City, KS USA; Department of Pathology and Laboratory Medicine; University of Kansas Medical Center; Kansas City, KS USA.
Arindam
A
Paul
The University of Kansas Cancer Center; University of Kansas Medical Center; Kansas City, KS USA; Department of Pathology and Laboratory Medicine; University of Kansas Medical Center; Kansas City, KS USA.
Soumen
S
Paul
ES cells; PKClamda/iota; breast cancer; cell; development; iPSC; pluripotency; triple negative breast cancer