Unexpected oncosuppressive role for STAT3 in KRAS-induced lung tumorigenesis.
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in the pathogenesis of several diseases and is considered a therapeutic target in solid cancers, including lung cancer. However, we recently demonstrated a tumor suppressive function of STAT3 in kirsten rat sarcoma oncogene homolog (KRAS)-driven lung cancer. Here, we discuss these findings and their consequences.
Ludwig Boltzmann Institute for Cancer Research (LBI-CR) , Vienna, Austria.
Beatrice
B
Grabner
Institute of Pharmacology, Medical University of Vienna , Vienna, Austria.
Herwig P
HP
Moll
Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna, Austria; Institute of Physiology, Center of Physiology and Pharmacology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Emilio
E
Casanova