Au Nanocage Functionalized with Ultra-small Fe3O4 Nanoparticles for Targeting T1-T2Dual MRI and CT Imaging of Tumor.
Diagnostic approaches based on multimodal imaging of clinical noninvasive imaging (eg. MRI/CT scanner) are highly developed in recent years for accurate selection of the therapeutic regimens in critical diseases. Therefore, it is highly demanded in the development of appropriate all-in-one multimodal contrast agents (MCAs) for the MRI/CT multimodal imaging. Here a novel ideal MCAs (F-AuNC@Fe3O4) were engineered by assemble Au nanocages (Au NC) and ultra-small iron oxide nanoparticles (Fe3O4) for simultaneous T1-T2dual MRI and CT contrast imaging. In this system, the Au nanocages offer facile thiol modification and strong X-ray attenuation property for CT imaging. The ultra-small Fe3O4 nanoparticles, as excellent contrast agent, is able to provide great enhanced signal of T1- and T2-weighted MRI (r1 = 6.263 mM(-1) s(-1), r2 = 28.117 mM(-1) s(-1)) due to their ultra-refined size. After functionalization, the present MCAs nanoparticles exhibited small average size, low aggregation and excellent biocompatible. In vitro and In vivo studies revealed that the MCAs show long-term circulation time, renal clearance properties and outstanding capability of selective accumulation in tumor tissues for simultaneous CT imaging and T1- and T2-weighted MRI. Taken together, these results show that as-prepared MCAs are excellent candidates as MRI/CT multimodal imaging contrast agents.
College of Pharmacy &the Key Laboratory for Medical Tissue Engineering of Liaoning Province, Liaoning Medical University, Jinzhou, 121001, China.|Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, China.
Guannan
G
Wang
College of Pharmacy &the Key Laboratory for Medical Tissue Engineering of Liaoning Province, Liaoning Medical University, Jinzhou, 121001, China.
Wei
W
Gao
Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, China.
Xuanjun
X
Zhang
College of Pharmacy &the Key Laboratory for Medical Tissue Engineering of Liaoning Province, Liaoning Medical University, Jinzhou, 121001, China.
Xifan
X
Mei
D000072283:A549 Cells; D000818:Animals; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology; D006046:Gold / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D008297:Male; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism*
D003287:Contrast Media; D058185:Magnetite Nanoparticles; D006046:Gold