Glutathione S-transferase P1 rs1695 A>G polymorphism and breast cancer risk: evidence from a meta-analysis.
Breast cancer (BC) is the most widespread cause of cancer-related deaths in women. Many published studies have assessed the association between the glutathione S-transferase P1 (GSTP1) rs1695 polymorphism and BC risk. However, the effect of the GSTP1 rs1695 polymorphism on BC risk has remained controversial. Therefore, this meta-analysis was conducted to obtain a comprehensive estimation of this association. A total of 20,615 cases and 20,481 controls from thirty-six case-control trials were extracted from an online literature survey. The meta-analysis indicated that the GSTP1 rs1695 A>G polymorphism did not contribute to the susceptibility of BC when the overall population was considered. However, intriguingly, this polymorphism was significantly associated with increased risk of BC in Asian women [GG vs AA: odds ratio (OR) = 1.4, 95% confidence interval (CI): 1.06-1.88, P = 0.02; AG vs AA: OR = 1.08, 95%CI = 1.00-1.16, P = 0.05; GG/AG vs AA: OR = 1.11, 95%CI = 1.04-1.19, P = 0.00]. Moreover, a subgroup analysis based on the source of control groups showed a marked increase in BC susceptibility in hospital-based control subjects (GG vs AA: OR = 1.28, 95%CI = 1.10-1.48, P= 0.00; GG vs
OR = 1.22, 95%CI = 1.06-1.41, P = 0.00; GG/AG vs AA: OR = 1.10, 95%CI = 1.02-1.18, P = 0.00). In conclusion, our study indicated that the GSTP1 rs1695 A>G polymorphism was correlated with elevated BC risk in Asian women. Our results must be validated with further research.
Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.|Department of Oncology, Liyang People's Hospital, Liyang Jiangsu Province, China.
M
M
Kuang
Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
W
W
Xu
Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
C X
CX
Cao
Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
L L
LL
Shen
Department of Oncology, Taixing people's Hospital, Yangzhou University, Taixing, China.
J
J
Chang
Department of Oncology, Nantong Tumour Hospital, Nantong University, Nantong, China.
X L
XL
Zhang
Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
J F
JF
Chen
Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
C J
CJ
Tang
D044466:Asian People / Q000235:genetics; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi