Airway remodeling: Systems biology approach, from bench to bedside.
Airway Remodeling, a patho-physiologic process, is considered as a key feature of chronic airway diseases. In recent years, our understanding of the complex diseases has increased significantly by the use of combined approaches, including systems biology, which may contribute to the development of personalized and predictive medicine approaches. Integrative analysis, along with the cooperation of clinicians, computer scientists, research scientists, and bench scientists, has become an important part of the experimental design and therapeutic strategies in the era of omics. The airway remodeling process is the result of the dysregulation of several signaling pathways that modulate the airway regeneration; therefore, high-throughput experiments and systems biology approach can help to understand this process better. The study reviews related literature and is consistent with the existing clinical evidence.
Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Ali
A
Najafi
Chemical Injury Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Mostafa
M
Ghanei
Chemical Injury Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Sadegh Azimzadeh
SA
Jamalkandi
D056151:Airway Remodeling / Q000502:physiology*; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000503:physiopathology*; D049490:Systems Biology
Airway remodeling; clinical strategy; systems biology