Epidemiology of carbapenem-resistant Klebsiella pneumoniae colonization: a surveillance study at a Turkish university hospital from 2009 to 2013.
Between June 2009 and December 2013, 4105 patients were screened for carbapenem-resistant Klebsiella pneumoniae (CR-Kp) colonization in a tertiary care university hospital. The antimicrobial susceptibility and resistance determinants of 279 (6.8%) CR-Kp isolates from single patients were investigated. Additional analysis was performed to evaluate the characteristics and various risk factors for infection in patients with colonization. Of the 279 isolates, 270 harboured OXA-48-like enzymes, and a single isolate harboured IMP-type carbapenemase. A high proportion of isolates were susceptible to carbapenems - except ertapenem. All isolates were susceptible to amikacin and most (94%) were susceptible to colistin and fosfomycin. There was consistent high-level resistance for all isolates to temocillin, piperacillin-tazobactam, amoxicillin-clavulanate and ticarcillin-clavulanate. When colonized and infected patients were compared, only prior carbapenem administration (P = 0.003), was found to be significantly associated with patients with CR-Kp infection.
Hacettepe University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey. Electronic address: pzarakolu@hotmail.com.
Pinar
P
Zarakolu
Hacettepe University Faculty of Medicine, Department of Medical Microbiology, Ankara, Turkey.
Ozgen Koseoglu
OK
Eser
Hacettepe University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey.
Elifcan
E
Aladag
Microbiology Department, Freeman Hospital, Newcastle upon Tyne, UK; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King, Abdulaziz University, Jeddah, Saudi Arabia.
Ibrahim A
IA
Al-Zahrani
Microbiology Department, Freeman Hospital, Newcastle upon Tyne, UK.
Kathryn M
KM
Day
Hacettepe University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey.
Ozgur
O
Atmaca
Hacettepe University Faculty of Medicine, Department of Medical Microbiology, Ankara, Turkey.
Baris
B
Boral
Hacettepe University Faculty of Medicine, Department of Public Health, Ankara, Turkey.
Banu
B
Cakir
Microbiology Department, Freeman Hospital, Newcastle upon Tyne, UK.
John D
JD
Perry
Hacettepe University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey.
Murat
M
Akova
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology; D062665:Epidemiological Monitoring; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D062606:Tertiary Care Centers; D014421:Turkey; D055815:Young Adult; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000032:analysis
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D001618:beta-Lactamases
Antimicrobial susceptibility; Carbapenem- resistant Klebsiella pneumoniae; Carbapenemases; Colonization; OXA-48 carbapenemase