Prognostic Model to Predict Survival Outcome for Curatively Resected Liposarcoma: A Multi-Institutional Experience.
OBJECTIVE
We performed this study to analyze the clinical features and prognosis of Korean patients with liposarcoma.


METHODS
Between October 1986 and April 2013, 231 patients who were diagnosed with liposarcoma by histologic examination were enrolled in this study.


RESULTS
The distribution of histologic subtypes was well-differentiated (n = 97, 42%), myxoid (n = 74, 32%), dedifferentiated (n = 32, 13.9%), pleomorphic (n = 15, 6.5%), and round-cell liposarcoma (n = 13, 5.6%). The majority of liposarcomas were located in the lower extremities (35.5%) and retroperitoneum (34.2%). Prognosis was worse for the trunk group compared with the extremity group (median disease-free survival [DFS] 3.3 vs. 9.9 years, respectively, P <0.001). Median DFS was significantly worse in patients with high grade histology compared to those with low grade histology (16.9% vs. 65.7%, P <0.001). The independent prognostic factors associated with survival were histology (hazard ratio [HR] 3.01; 95% confidence interval [CI], 1.82-4.97; P <0.001) and primary site (HR 1.80; 95% CI, 1.12-2.89; P = 0.015). Three risk groups with different survival outcomes were identified: group 1 (n = 98), no risk factors; group 2 (n = 92), one risk factor; and group 3 (n = 41), two risk factors.


CONCLUSIONS
Histologic subtype and primary site were independent prognostic factors for curatively resected liposarcoma. A prognostic model for patients with liposarcoma clarified distinct groups of patients with good prognostic discrimination.
1. Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea;
Yoon Jung
YJ
Oh
2. Division of Hematology-Oncology, Department of Internal Medicine, Inje University Ilsan Paik Hospital; Ilsan, Korea;
Seong Yoon
SY
Yi
3. Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea;
Ki Hyang
KH
Kim
4. Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea;
Yong Jin
YJ
Cho
5. Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea;
Seung Hoon
SH
Beum
6. Department of Radiology, Yonsei University College of Medicine, Seoul, Korea;
Young Han
YH
Lee
6. Department of Radiology, Yonsei University College of Medicine, Seoul, Korea;
Jin-Suck
JS
Suh
7. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea;
Hyuk
H
Hur
7. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea;
Kyung Sik
KS
Kim
8. Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea;
Sung Hoon
SH
Kim
9. Department of Urology, Yonsei University College of Medicine, Seoul, Korea;
Young Deuk
YD
Choi
4. Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea;
Kyoo-Ho
KH
Shin
10. Division of Medical Oncology & Hematology, Department of Internal Medicine, Seoul Medical Center, Seoul, Korea;
Hyun Jung
HJ
Jun
11. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;
Sung Joo
SJ
Kim
12. Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Jeeyun
J
Lee
12. Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Se Hoon
SH
Park
7. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea;
Sung Hoon
SH
Noh
5. Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea;
Sun Young
SY
Rha
5. Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea;
Hyo Song
HS
Kim
Asian; Liposarcoma; Prognostic model; Survival.