A novel miRNA-mediated STOP sign in lung cancer: miR-340 inhibits the proliferation of lung cancer cells through p27(KIP1).
Oncosuppressor miRNAs inhibit cancer cell proliferation by targeting key components of the cell cycle machinery. In our recent report we showed that miR-340 is a novel tumor suppressor in non-small cell lung cancer. miR-340 inhibits neoplastic cell proliferation and induces p27(KIP1) by targeting multiple translational and post-translational regulators of this cyclin-dependent kinase inhibitor.
Institute of Genetics and Biophysics Adriano Buzzati-Traverso; CNR ; Naples, Italy.
Serena
S
Fernandez
Institute of Genetics and Biophysics Adriano Buzzati-Traverso; CNR ; Naples, Italy.
Maurizio
M
Risolino
Institute of Genetics and Biophysics Adriano Buzzati-Traverso; CNR ; Naples, Italy.
Pasquale
P
Verde
SKP2; miR-340; p27KIP1; pumilio; tumor suppressor