Plasma myostatin levels are related to the extent of right ventricular dysfunction in exacerbation of chronic obstructive pulmonary disease.
OBJECTIVE
To investigate the relationship between plasma myostatin levels and right ventricle (RV) dysfunction (RVD) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD).


METHODS
The study recruited 84 patients with AECOPD. Plasma myostatin was analyzed and tricuspid annular plane systolic excursion (TAPSE) < 16 mm was used as the main indicator for RVD.


RESULTS
Plasma myostatin levels were significantly higher in 47 patients with RVD than 37 ones without (P < 0.005). Multivariate regression analysis revealed that myostatin levels correlated significantly with TAPSE values and RV myocardial performance index (p < 0.001) among the study patients.


CONCLUSIONS
Plasma myostatin is a potential biomarker for improving diagnosis of RVD in AECOPD.
a State Key Lab of the Respiratory Disease, Guangzhou Institute of Respiratory Disease , First Affiliated Hospital of Guangzhou Medical University , Guangdong , China.
Chun-Rong
CR
Ju
a State Key Lab of the Respiratory Disease, Guangzhou Institute of Respiratory Disease , First Affiliated Hospital of Guangzhou Medical University , Guangdong , China.
Jian-Heng
JH
Zhang
a State Key Lab of the Respiratory Disease, Guangzhou Institute of Respiratory Disease , First Affiliated Hospital of Guangzhou Medical University , Guangdong , China.
Miao
M
Chen
a State Key Lab of the Respiratory Disease, Guangzhou Institute of Respiratory Disease , First Affiliated Hospital of Guangzhou Medical University , Guangdong , China.
Rong-Chang
RC
Chen
D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D055435:Myostatin / Q000097:blood*; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D014261:Tricuspid Valve / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000097:blood / Q000175:diagnosis* / Q000209:etiology
D015415:Biomarkers; C525911:MSTN protein, human; D055435:Myostatin
Chronic obstructive pulmonary disease; myostatin; pulmonary arterial hypertension; right ventricle; tricuspid annular plane systolic excursion