The Role of Lymphatic Niches in T Cell Differentiation.
Long-term immunity to many viral and bacterial pathogens requires CD8(+) memory T cell development, and the induction of long-lasting CD8(+) memory T cells from a naïve, undifferentiated state is a major goal of vaccine design. Formation of the memory CD8(+) T cell compartment is highly dependent on the early activation cues received by naïve CD8(+) T cells during primary infection. This review aims to highlight the cellularity of various niches within the lymph node and emphasize recent evidence suggesting that distinct types of T cell activation and differentiation occur within different immune contexts in lymphoid organs.
Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY 14642, USA.
Tara
T
Capece
Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY 14642, USA.
Minsoo
M
Kim
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D015195:Drug Design; D006801:Humans; D007156:Immunologic Memory; D008198:Lymph Nodes / Q000276:immunology*; D055153:Stem Cell Niche; D014612:Vaccines / Q000276:immunology
D014612:Vaccines
CD8 T cell; T cell; chemokine; immune memory; lymph node