Smad4/DPC4: A barrier against tumor progression driven by RTK/Ras/Erk and Wnt/GSK3 signaling.
The tumor suppressor Smad4/DPC4 is an essential transcription factor in the TGF-β pathway that was previously thought to function constitutively. We recently reported that Smad4 activity and stability are directly regulated by 2 major signaling pathways, RTK/MAPK and Wnt/GSK3. Here we examine the molecular, cellular, and potential therapeutic significance of these findings.
Howard Hughes Medical Institute and Department of Biological Chemistry; University of California ; Los Angeles, CA USA.
Hadrien
H
Demagny
Howard Hughes Medical Institute and Department of Biological Chemistry; University of California ; Los Angeles, CA USA.
Edward M
EM
De Robertis
EGF; Erk; FGF; GSK3; Ras; Smad; TGF-β; Wnt; tumor suppressor; β-TrCP