Evolution of Cytokine Receptor Signaling.
Cytokines represent essential mediators of cell-cell communication with particularly important roles within the immune system. These secreted factors are produced in response to developmental and/or environmental cues and act via cognate cytokine receptors on target cells, stimulating specific intracellular signaling pathways to facilitate appropriate cellular responses. This review describes the evolution of cytokine receptor signaling, focusing on the class I and class II receptor families and the downstream JAK-STAT pathway along with its key negative regulators. Individual components generated over a long evolutionary time frame coalesced to form an archetypal signaling pathway in bilateria that was expanded extensively during early vertebrate evolution to establish a substantial "core" signaling network, which has subsequently undergone limited diversification within discrete lineages. The evolution of cytokine receptor signaling parallels that of the immune system, particularly the emergence of adaptive immunity, which has likely been a major evolutionary driver.
School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia; and Centre for Molecular and Medical Research, Deakin University, Waurn Ponds, Victoria 3216, Australia.
Clifford
0000-0002-1646-4905
C
Liongue
School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia; and Centre for Molecular and Medical Research, Deakin University, Waurn Ponds, Victoria 3216, Australia.
Robert
R
Sertori
School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia; and Centre for Molecular and Medical Research, Deakin University, Waurn Ponds, Victoria 3216, Australia award@deakin.edu.au.
Alister C
0000-0001-7945-7975
AC
Ward
D056704:Adaptive Immunity; D000818:Animals; D005075:Biological Evolution; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D018121:Receptors, Cytokine / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D050826:Suppressor of Cytokine Signaling Proteins / Q000276:immunology*
D016207:Cytokines; D018121:Receptors, Cytokine; D050826:Suppressor of Cytokine Signaling Proteins