Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1.
During the initiation stage of pancreatic adenocarcinoma induced by oncogenic Kras, pancreatic cells are exposed to both a protumoral effect and an opposing tumor suppressive process known as oncogene-induced senescence. Pancreatitis disrupts this balance in favor of the transforming effect of oncogenes by lowering the tumor suppressive threshold of oncogene-induced senescence through expression of the stress protein Nupr1.
Centre de Recherche en Cancérologie de Marseille (CRCM); Aix-Marseille Université and Institut Paoli-Calmettes; Parc Scientifique et Technologique de Luminy; Marseille, France.
Daniel
D
Grasso
Centre de Recherche en Cancérologie de Marseille (CRCM); Aix-Marseille Université and Institut Paoli-Calmettes; Parc Scientifique et Technologique de Luminy; Marseille, France.
Maria Noé
MN
Garcia
Centre de Recherche en Cancérologie de Marseille (CRCM); Aix-Marseille Université and Institut Paoli-Calmettes; Parc Scientifique et Technologique de Luminy; Marseille, France.
Tewfik
T
Hamidi
Centre de Recherche en Cancérologie de Marseille (CRCM); Aix-Marseille Université and Institut Paoli-Calmettes; Parc Scientifique et Technologique de Luminy; Marseille, France.
Carla
C
Cano
Molecular Endocrinology and Oncology Research Center; CHUL Research Center; Quebec, QC Canada.
Ezequiel
E
Calvo
Laboratory of Epigenetics and Chromatin Dynamics; Gastroenterology Research Unit; Departments of Biochemistry and Molecular Biology, Biophysics, and Medicine; Mayo Clinic; Rochester, MA USA.
Gwen
G
Lomberk
Laboratory of Epigenetics and Chromatin Dynamics; Gastroenterology Research Unit; Departments of Biochemistry and Molecular Biology, Biophysics, and Medicine; Mayo Clinic; Rochester, MA USA.
Raul
R
Urrutia
Centre de Recherche en Cancérologie de Marseille (CRCM); Aix-Marseille Université and Institut Paoli-Calmettes; Parc Scientifique et Technologique de Luminy; Marseille, France.
Juan L
JL
Iovanna
Kras; Nupr1; PanIN; pancreatic cancer; senescence