Soluble ICAM-1, Independent of IL-6, Is Associated with Prevalent Frailty in Community-Dwelling Elderly Taiwanese People.
BACKGROUND
Activation of inflammatory pathway with elevation of inflammatory biomarkers such as Interleukin 6 (IL-6) has been considered a pathophysiological feature of frailty. In recent years, the association between Intercellular adhesive molecule -1 (ICAM-1) and vascular inflammatory was established. Provocation of inflammatory cascades from ICAM-1 is potential IL-6 related, although the association between the inflammatory process and frailty is little to known. The study was intended to evaluate the relationship between serum ICAM-1, IL-6 and frailty.


METHODS
Data was derived from a representative national sampling cohort in Taiwan. The cross-sectional study included nine-hundred-forty-six community-dwelling people aged 53 and older. Frailty was defined as having three or more components (including, muscle shrinkage, slowness, weakness, exhaustion, and low activity) Serum IL-6 and ICAM-1 levels were measured using standard enzyme-linked immunosorbent assays.


RESULTS
Soluble ICAM-1 (sICAM-1) levels were stepwise increased in non-frail, pre-frail and frail elderly people (the median levels were 255 vs. 265 vs. 285 ng/ml, respectively p<0.001). A multivariate multinomial logistic regression, which was adjusted for age, sex, smoking, education, BMI, and chronic disease number, was utilized to determine that the probability of being frail due to increased log (ICAM-1) and log (IL-6) standard deviation levels were 1.44 (95% CI 1.09-1.91) and 1.54 (95%CI 1.07-2.20), respectively.


CONCLUSIONS
sICAM-1 was significantly associated with frailty, independent of IL-6. This implied that leukocyte migration and inflammation cascade activation might contribute to frailty, in addition to monocyte/macrophage-mediated immuno-inflammation.
Aging and Health Research Center, National Yang Ming University,Taipei City, Taiwan.|Institute of Public Health, National Yang Ming University, Taipei City, Taiwan.|Department of Family Medicine, Taipei Veterans General Hospital Yuanshan Branch,Yilan County, Taiwan.
Wei-Ju
WJ
Lee
Aging and Health Research Center, National Yang Ming University,Taipei City, Taiwan.|Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei City, Taiwan.
Liang-Kung
LK
Chen
Aging and Health Research Center, National Yang Ming University,Taipei City, Taiwan.|Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaoshiung City, Taiwan.
Chih-Kuang
CK
Liang
Aging and Health Research Center, National Yang Ming University,Taipei City, Taiwan.|Institute of Public Health, National Yang Ming University, Taipei City, Taiwan.|Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei City, Taiwan.
Li-Ning
LN
Peng
Institute of Public Health, National Yang Ming University, Taipei City, Taiwan.|Health Promotion Administration, Ministry of Health and Welfare,Taipei City Taiwan.
Shu-Ti
ST
Chiou
Institute of Public Health, National Yang Ming University, Taipei City, Taiwan.
Pesus
P
Chou
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005221:Fatigue / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D016330:Frail Elderly; D015870:Gene Expression; D006801:Humans; D057187:Independent Living; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood* / Q000235:genetics / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood* / Q000235:genetics / Q000276:immunology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology*; D018482:Muscle, Skeletal / Q000276:immunology / Q000503:physiopathology; D012737:Sex Factors; D013624:Taiwan
D015415:Biomarkers; C573420:ICAM1 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D018799:Intercellular Adhesion Molecule-1