Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism.
The metabolic function of p53 is important for its oncosuppressive function. Mutant p53 (mutp53) with gain of oncogenic function can regulate cell metabolism. Our recent study revealed a novel transcription-independent mechanism for a gain-of-function mutp53 that directly inhibits activation of adenosine monophosphate-activated protein kinase (AMPK) to promote cancer cell metabolism.
Department of Head and Neck Surgery; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
Ge
G
Zhou
Department of Head and Neck Surgery; The University of Texas MD Anderson Cancer Center; Houston, TX USA; Department of Cancer Biology; The University of Texas MD Anderson Cancer Center; Houston, TX USA.
Jeffrey N
JN
Myers
AMPK; gain of function; metabolism; mutant p53; p53; p53 mutation