Temporal changes in mammalian target of rapamycin (mTOR) and phosphorylated-mTOR expressions in the hippocampal CA1 region of rat with vascular dementia.
Mammalian target of rapamycin (mTOR) has an important role in various biological processes in cells. In the present study, we investigated temporal changes in mTOR and phosphorylated-mTOR (p-mTOR) expressions in the rat hippocampal CA1 region following chronic cerebral hypoperfusion (CCH) induced by permanent bilateral common carotid arteries occlusion (2VO). The mTOR immunoreactivity in the pyramidal neurons and mTOR protein level in the hippocampal CA1 region were markedly decreased at 21 and 28 days after 2VO surgery. However, p-mTOR protein expression was significantly increased at 7 days following CCH but then decreased with time. The results indicate that mTOR and p-mTOR expressions change in the hippocampal CA1 region after 2VO surgery and that reduced expressions of mTOR and p-mTOR may be closely related to the CCH-induced neuronal damage in the hippocampal CA1 region.
Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Korea.
Jin-A
JA
Park
Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Korea.
Choong-Hyun
CH
Lee
D000818:Animals; D002545:Brain Ischemia / Q000209:etiology / Q000503:physiopathology*; D056547:CA1 Region, Hippocampal / Q000378:metabolism / Q000503:physiopathology*; D015140:Dementia, Vascular / Q000209:etiology / Q000503:physiopathology*; D015870:Gene Expression; D008297:Male; D010766:Phosphorylation; D051381:Rats; D017207:Rats, Sprague-Dawley; D058570:TOR Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism
C546845:mTOR protein, rat; D058570:TOR Serine-Threonine Kinases
chronic cerebral hypoperfusion; hippocampal CA1 region; mammals; sirolimus; vascular dementia