Melanoma metastases caught in the AKT.
Dysregulated protein kinase B alpha (PKB/AKT1) signaling has been increasingly implicated in melanoma metastasis to distant organs, especially the brain. In a recent study, we expressed activated AKT1 in a non-metastatic melanoma model in vivo and discovered that AKT1 activation decreased tumor latency and elicited lung and brain metastases in this context.
Department of Oncological Sciences, University of Utah Health Sciences Center , Salt Lake City, Utah, USA.
David A
DA
Kircher
Department of Chemistry, University of Utah Health Sciences Center , Salt Lake City, Utah, USA.
Rowan A
RA
Arave
Department of Oncological Sciences, University of Utah Health Sciences Center , Salt Lake City, Utah, USA.
Joseph H
JH
Cho
Department of Oncological Sciences, University of Utah Health Sciences Center, Salt Lake City, Utah, USA; Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah, USA; Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Sheri L
SL
Holmen
AKT; Melanoma; Metastases; Mouse; Pten