Syntheses of (14β,17α)-14-Hydroxy- and (14β,17α)-2,14-Dihydroxyestradiols and Their Activities.
Structure 1 is proposed for the Inagami-Tamura endogenous digitalis-like factor (EDLF), and (14β,17α)-14-hydroxy- and (14β, 17α)-2,14-dihydroxyestradiols (2 and 3) were synthesized as models for studies on 1. The latter compound was remarkably potent in inducing a contractile response in isolated rat aorta and guinea pig left atrium.
a Pharmaceutical Research Laboratories , Kirin Brewery Co., Ltd , 3 Miyahara-cho, Takasaki, Gunma 370-12 , Japan.
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Sakakibara
a Pharmaceutical Research Laboratories , Kirin Brewery Co., Ltd , 3 Miyahara-cho, Takasaki, Gunma 370-12 , Japan.
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Ogawa Uchida
14β-hydroxyestrogens; cardiotonic; endogenous digitalis-like factor; hypertension; vasocontraction