P-glycoprotein Mediated Efflux Modulators of Plant Origin: A Short Review.
Drug efflux transporters such as P-glycoprotein (P-gp) help maintain cellular homeostasis but are also major contributors to the development of multidrug resistance (MDR) phenomena. Since P-gp was associated with MDR, several compounds showing potential to inhibit this transporter have been identified. Particular attention has been given to natural products, namely those of plant origin, looking for highly effective and safe P-gp inhibitors with little to no interaction with other cellular or metabolic processes. Here we abridge several examples of plant compounds from distinct classes, polyketides, lignans, anthraquinones, coumarins, alkaloids, mono- and sesqui-terpenes, steroids and limonoids, which have shown the ability to modulate in vitro or in vivo the P-gp activity.
Nuno
N
Silva
Lígia
L
Salgueiro
Ana
A
Fortuna
Carlos
C
Cavaleiro
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D000470:Alkaloids / Q000737:chemistry; D010636:Phenols / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000470:Alkaloids; D010636:Phenols; D010936:Plant Extracts; D013729:Terpenes