Glycan Arrays: From Basic Biochemical Research to Bioanalytical and Biomedical Applications.
A major branch of glycobiology and glycan-focused biomedicine studies the interaction between carbohydrates and other biopolymers, most importantly, glycan-binding proteins. Today, this research into glycan-biopolymer interaction is unthinkable without glycan arrays, tools that enable high-throughput analysis of carbohydrate interaction partners. Glycan arrays offer many applications in basic biochemical research, for example, defining the specificity of glycosyltransferases and lectins such as immune receptors. Biomedical applications include the characterization and surveillance of influenza strains, identification of biomarkers for cancer and infection, and profiling of immune responses to vaccines. Here, we review major applications of glycan arrays both in basic and applied research. Given the dynamic nature of this rapidly developing field, we focus on recent findings.
Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, 14476 Potsdam, Germany.|Institute for Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany; email: peter.seeberger@mpikg.mpg.de.
Andreas
A
Geissner
Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, 14476 Potsdam, Germany.|Institute for Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany; email: peter.seeberger@mpikg.mpg.de.
Peter H
PH
Seeberger
D035843:Biomedical Research; D046228:Microarray Analysis; D011134:Polysaccharides / Q000032:analysis*
D011134:Polysaccharides
biomarkers; cancer; glycoconjugate vaccines; infectious diseases; lectins