Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome.
Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, Australia; St Vincent's Clinical School, University of New South Wales Australia, Darlinghurst, Australia.
Simon J
SJ
Pelham
St Vincent's Clinical School, University of New South Wales Australia, Darlinghurst, Australia.
Helen C
HC
Lenthall
Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, Australia; St Vincent's Clinical School, University of New South Wales Australia, Darlinghurst, Australia. Electronic address: e.deenick@garvan.org.au.
Elissa K
EK
Deenick
Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, Australia; St Vincent's Clinical School, University of New South Wales Australia, Darlinghurst, Australia. Electronic address: s.tangye@garvan.org.au.
Stuart G
SG
Tangye
D019943:Amino Acid Substitution; D005799:Genes, Dominant; D057809:HEK293 Cells; D006801:Humans; D007589:Job Syndrome / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D050505:Mutant Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D009154:Mutation; D010766:Phosphorylation / Q000235:genetics; D055503:Protein Multimerization / Q000235:genetics; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
D050505:Mutant Proteins; D011994:Recombinant Proteins; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human