Inflammatory bowel disease: A descriptive study of 716 local Chilean patients.
OBJECTIVE
To demographically and clinically characterize inflammatory bowel disease (IBD) from the local registry and update data previously published by our group.


METHODS
A descriptive study of a cohort based on a registry of patients aged 15 years or older who were diagnosed with IBD and attended the IBD program at Clínica Las Condes in Santiago, Chile. The registry was created in April 2012 and includes patients registered up to October 2015. The information was anonymously downloaded in a monthly report, and the information on patients with more than one visit was updated. The registry includes demographic, clinical and disease characteristics, including the Montreal Classification, medical treatment, surgeries and hospitalizations for crisis. Data regarding infection with Clostridium difficile (C. difficile) were incorporated in the registry in 2014. Data for patients who received consultations as second opinions and continued treatment at this institution were also analyzed.


RESULTS
The study included 716 patients with IBD: 508 patients (71%) were diagnosed with ulcerative colitis (UC), 196 patients (27%) were diagnosed with Crohn's disease (CD) and 12 patients (2%) were diagnosed with unclassifiable IBD. The UC/CD ratio was 2.6/1. The median age was 36 years (range 16-88), and 58% of the patients were female, with a median age at diagnosis of 29 years (range 5-76). In the past 15 years, a sustained increase in the number of patients diagnosed with IBD was observed, where 87% of the patients were diagnosed between the years 2001 and 2015. In the cohort examined in the present study, extensive colitis (50%) and colonic involvement (44%) predominated in the patients with UC and CD, respectively. In CD patients, non-stricturing/non-penetrating behavior was more frequent (80%), and perianal disease was observed in 28% of the patients. There were significant differences in treatment between UC and CD, with a higher use of corticosteroids, and immunosuppressive and biological therapies was observed in the patients with CD (P < 0.05 and P < 0.01). Significant surgical differences were also observed: 5% of the UC patients underwent surgery, whereas 38% of the CD patients required at least one surgery (P < 0.01). The patients with CD were hospitalized more often during their disease course than the patients with UC (55% and 35% of the patients, respectively; P < 0.01). C. difficile infection was acquired by 5% of the patients in each group at some point during the disease course. Nearly half of the patients consulted at the institution for a second opinion, and 32% of these individuals continued treatment at the institution.


CONCLUSIONS
IBD has continued to increase in the study cohort, slowly approaching the level reported in developed countries.
Daniela Simian, Academic Research Unit, Clínica Las Condes, Santiago 7591046, Chile.
Daniela
D
Simian
Daniela Simian, Academic Research Unit, Clínica Las Condes, Santiago 7591046, Chile.
Daniela
D
Fluxá
Daniela Simian, Academic Research Unit, Clínica Las Condes, Santiago 7591046, Chile.
Lilian
L
Flores
Daniela Simian, Academic Research Unit, Clínica Las Condes, Santiago 7591046, Chile.
Jaime
J
Lubascher
Daniela Simian, Academic Research Unit, Clínica Las Condes, Santiago 7591046, Chile.
Patricio
P
Ibáñez
Daniela Simian, Academic Research Unit, Clínica Las Condes, Santiago 7591046, Chile.
Carolina
C
Figueroa
Daniela Simian, Academic Research Unit, Clínica Las Condes, Santiago 7591046, Chile.
Udo
U
Kronberg
Daniela Simian, Academic Research Unit, Clínica Las Condes, Santiago 7591046, Chile.
Raúl
R
Acuña
Daniela Simian, Academic Research Unit, Clínica Las Condes, Santiago 7591046, Chile.
Mauricio
M
Moreno
Daniela Simian, Academic Research Unit, Clínica Las Condes, Santiago 7591046, Chile.
Rodrigo
R
Quera
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D001688:Biological Products / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D016360:Clostridioides difficile / Q000472:pathogenicity; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D003424:Crohn Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D013505:Digestive System Surgical Procedures; D004761:Enterocolitis, Pseudomembranous / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006760:Hospitalization; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012017:Referral and Consultation; D012042:Registries; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
D001688:Biological Products; D005765:Gastrointestinal Agents; D007166:Immunosuppressive Agents
Chile; Crohn’s disease; Epidemiology; Inflammatory bowel disease; Latin America; South America; Ulcerative colitis