Selective Determination of Atropine Using poly Dopamine-Coated Molecularly Imprinted Mn-Doped ZnS Quantum Dots.
In this study, a selective method for the determination of atropine in pharmaceutical formulations was proposed. L-cysteine capped Mn-doped ZnS quantum dots (QDs) were prepared in an in-situ method using sodium thiosulfate precursor and characterized by spectrofluorometer, Fourier transform infrared spectroscopy (FT-IR), transmission electron microscope (TEM) and X-ray diffractometer (XRD). Dopamine hydrochloride was used as a precursor for preparation of poly dopamine-coated molecularly imprinted Mn-doped ZnS quantum dots. Finally, these prepared molecularly imprinted Mn-doped ZnS quantum dots were used for determination of atropine in pharmaceutical formulations. The obtained linear range for determination of atropine was in the range of 2 × 10(-8) - 7 × 10(-6) M, with a correlation coefficient (R(2)) of 0.9889; and the detection limit (S/N = 3) was 3.2 nM.
Department of Chemistry, University of Mazandaran, Babolsar, Iran.
Javad
J
Abbasifar
Department of Chemistry, University of Mazandaran, Babolsar, Iran. samadi@umz.ac.ir.
Abdolraouf
A
Samadi-Maybodi
D001285:Atropine / Q000032:analysis*; D004298:Dopamine / Q000737:chemistry*; D004339:Drug Compounding; D006801:Humans; D057230:Limit of Detection; D008345:Manganese / Q000737:chemistry*; D054802:Molecular Imprinting / Q000379:methods*; D045663:Quantum Dots; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared; D013440:Sulfides / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry*
D013440:Sulfides; D017967:Zinc Compounds; D008345:Manganese; D001285:Atropine; C031238:zinc sulfide; D004298:Dopamine
Atropine; Mn-dopped ZnS; Molecularly imprinted polymers; Poly dopamine; Quantum dots