SAT1 and glioblastoma multiforme: Disarming the resistance.
Glioblastoma multiforme is the most common and most detrimental form of brain tumor, with a current survival time of as little as 14 months. We have recently identified a novel mechanism of therapeutic resistance based on overexpression of the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase, which promotes DNA repair via chromatin modification.
Department of Radiation Oncology; School of Medicine; Case Western Reserve University ; 10900 Euclid Avenue; Cleveland, OH USA.
Adina
A
Brett-Morris
Department of Radiation Oncology; School of Medicine; Case Western Reserve University ; 10900 Euclid Avenue; Cleveland, OH USA.
Mazen
M
Mislmani
Department of Radiation Oncology; School of Medicine; Case Western Reserve University ; 10900 Euclid Avenue; Cleveland, OH USA.
Scott M
SM
Welford
BRCA1; SAT1; glioblastoma; histone acetylation; radiation resistance