XIAP as a regulator of inflammatory cell death: the TNF and RIP3 angle.
There is currently immense interest in understanding the biological consequences of aberrant necroptosis. The recently uncovered role for X-linked inhibitor of apoptosis protein (XIAP) in blocking tumor necrosis factor-dependent necroptosis explains, at least in part, the systemic hyperinflammatory syndrome XLP-2. However, it also points to rather unexpected differences between XIAP and the related proteins baculoviral IAP repeat containing 2 and 3 (cIAP1/2).
III. Medizinische Klink; Klinikum rechts der Isar; Technische Universität München ; Germany.
Monica
M
Yabal
III. Medizinische Klink; Klinikum rechts der Isar; Technische Universität München ; Germany.
Philipp J
PJ
Jost
RIP3; XIAP; XLP-2; cIAP1; cIAP2; cell death; inflammation; necroptosis