Mitochondrial survivin - an Achilles' heel in cancer chemoresistance.
The metabolic shift from oxidative phosphorylation to glycolysis as a hallmark of highly aggressive cancer was postulated by Otto Warburg in the 1920s. We identified baculoviral IAP repeat-containing 5 (BIRC5, also known as survivin) as a key player in mitochondrial metabolism and our recent findings suggest glycolysis inhibitors as powerful agents to overcome the antiapoptotic function of survivin in neuroblastoma.
Department of Pediatrics I, Medical University Innsbruck , Innsbruck, Austria.
Michael J
MJ
Ausserlechner
Department of Pediatrics II Medical University Innsbruck , Innsbruck, Austria.
Judith
J
Hagenbuchner
Autophagy; Warburg effect; glycolysis inhibitors; mitochondria; neuroblastoma