Comparison of the Pharmacological Effects of Paricalcitol Versus Calcitriol on Secondary Hyperparathyroidism in the Dialysis Population.
Management of secondary hyperparathyroidism (SHPT) in dialysis population includes the use of active vitamin D forms, among which paricalcitol was shown to be more effective at reducing parathyroid hormone (PTH) concentrations. A prospective randomized study comparing the effectiveness and safety of peroral paricalcitol and calcitriol in suppressing PTH concentrations in 20 hemodialysis patients was performed comparing the influence of agents on PTH suppression, calcium (Ca) and phosphate (P) level and calcium-phosphorus product (C×P). The study was performed in an "intent to treat" manner with primary end point in reduction of PTH level in the target area of 150 > PTH < 300 ng/L after 3 months. At the time point 3 months after therapy induction paricalcitol and calcitriol were equally efficient at correcting PTH levels, with paricalcitol showing significantly less calcemic effect than calcitriol.
Department of Nephrology, University Medical Center Ljubljana, Ljubljana, Slovenia.
Željka
Ž
Večerić-Haler
Department of Nephrology, University Medical Center Ljubljana, Ljubljana, Slovenia.
Karmen
K
Romozi
Department of Nephrology, University Medical Center Ljubljana, Ljubljana, Slovenia.
Manja
M
Antonič
Department of Nephrology, University Medical Center Ljubljana, Ljubljana, Slovenia.
Miha
M
Benedik
Department of Nephrology, University Medical Center Ljubljana, Ljubljana, Slovenia.
Jadranka Buturović
JB
Ponikvar
Department of Nephrology, University Medical Center Ljubljana, Ljubljana, Slovenia.
Rafael
R
Ponikvar
Department of Nephrology, University Medical Center Ljubljana, Ljubljana, Slovenia.
Bojan
B
Knap
D000284:Administration, Oral; D002117:Calcitriol / Q000008:administration & dosage* / Q000009:adverse effects; D002118:Calcium / Q000737:chemistry; D004872:Ergocalciferols / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods; D013997:Time Factors; D016896:Treatment Outcome
D004872:Ergocalciferols; D010281:Parathyroid Hormone; D010710:Phosphates; C084656:paricalcitol; D002117:Calcitriol; D002118:Calcium
Calcitriol; Hemodialysis; Paricalcitol; Secondary hyperparathyroidism