Small molecule targeting miR-34a for cancer therapy.
miR-34a functions as a tumor suppressor in many cancers. In a recent issue of Cancer Research, we describe a small molecule, Rubone, with strong anticancer activity. Rubone selectively restored miR-34a expression in hepatocellular carcinoma cells in which miR-34a was silenced. Restoration of miR-34a by Rubone represents a promising therapeutic approach against cancer.
School of Biomedical Sciences; Faculty of Medicine; The Chinese University of Hong Kong ; Shatin, Hong Kong.
Zhangang
Z
Xiao
School of Biomedical Sciences; Faculty of Medicine; The Chinese University of Hong Kong; Shatin, Hong Kong; State Key Laboratory of Digestive Disease; Institute of Digestive Disease; The Chinese University of Hong Kong; Shatin, Hong Kong; Shenzhen Research Institute; The Chinese University of Hong Kong; Shenzhen, China.
Yangchao
Y
Chen
anticancer drug; hepatocellular carcinoma; miR-34a