Personalized Clinical Decision Making in Gastrointestinal Malignancies: The Role of PET.
Gastrointestinal malignancies comprise a heterogeneous group of diseases that include both common and rare diseases with very different presentations and prognoses. The mainstay of treatment is surgery in combination with preoperative and adjuvant chemotherapy depending on clinical presentation and initial stages. This article outlines the potential use of fluorodeoxyglucose-PET/CT in clinical decision making with special regard to preoperative evaluation and response assessment in gastric cancer (including the gastroesophageal junction), pancreatic cancer (excluding neuroendocrine tumors), colorectal cancer, and gastrointestinal stromal tumors.
Department of Nuclear Medicine, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark; Division of Nuclear Medicine, Department of Radiology and Nuclear Medicine, Hospital of South West Jutland, Finsensgade 10, 6700 Esbjerg, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Winsløwsparken 19, 3, 5000 Odense C, Denmark. Electronic address: Soeren.hess@rsyd.dk.
Søren
S
Hess
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Winsløwsparken 19, 3, 5000 Odense C, Denmark; Department of Gastrointestinal Surgery, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark.
Ole Steen
OS
Bjerring
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Winsløwsparken 19, 3, 5000 Odense C, Denmark; Department of Clinical Oncology, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark.
Per
P
Pfeiffer
Department of Nuclear Medicine, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Winsløwsparken 19, 3, 5000 Odense C, Denmark.
Poul Flemming
PF
Høilund-Carlsen
D000066491:Clinical Decision-Making / Q000379:methods*; D005770:Gastrointestinal Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D041981:Gastrointestinal Tract / Q000000981:diagnostic imaging; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D057285:Precision Medicine / Q000379:methods*
Colorectal cancer; FDG; GIST; Gastric cancer; PET; Pancreatic cancer