[Oxytocin and postpartum depression].
BACKGROUND
Postpartum depression (PPD) is prevalent (about 10%) with a major impact on the mother and child health. At the hormonal level, poor regulation of oxytocin rate has a key role in depression. Recently, oxytocin has been used on psychiatric therapy, intranasal or intravenously, particularly in mood disorders. But, in obstetrics, this molecule is administered during childbirth. The objective of this study was to determine if intravenous administration of oxytocin could influence thymic state of the mother in the postpartum period.


METHODS
Literature review, after consultation of Pubmed and Sciencedirect databases, with the following keywords: oxytocin, postpartum depression, pregnancy, social behavior.


RESULTS
The effects of oxytocin in the PPD are part of a multifactorial mechanism (hormonal and social) that influences the hormonal effects of oxytocin. Oxytocin use in therapeutic was able to give conclusive results in psychiatry, the way and the optimal method of administration are not known. PPD is associated with administrated oxytocin during labour. Physiopathology remains unknown.


CONCLUSIONS
It is possible that oxytocin administered during childbirth is related with the onset or worsening of the PPD without defining if it's a cause or a consequence.
CHRU de Nantes, hôpital Mère-Enfant, 34, boulevard Jean-Monnet, 44000, Nantes, France.
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Cardaillac
CHRU de Tours, pôle gynécologie obstétrique-médecine fœtale-reproduction et génétique, 2, boulevard Tonnellé, 37000 Tours, France. Electronic address: carina.rua@univ-tours.fr.
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Rua
CHRU de Tours, pôle gynécologie obstétrique-médecine fœtale-reproduction et génétique, 2, boulevard Tonnellé, 37000 Tours, France; UMR Inserm U930, université François-Rabelais de Tours, 10, boulevard Tonnellé, 37000 Tours, France.
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Simon
CHRU de Tours, clinique psychiatrique universitaire, 2, boulevard Tonnellé, 37000 Tours, France; UMR Inserm U930, université François-Rabelais de Tours, 10, boulevard Tonnellé, 37000 Tours, France.
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El-Hage
D000328:Adult; D019052:Depression, Postpartum / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D010121:Oxytocin / Q000009:adverse effects / Q000378:metabolism*; D011247:Pregnancy
D010121:Oxytocin
Dépression du post-partum; Hormone; Ocytocine; Oxytocin; Oxytocine; Postpartum depression