Devil's Wake: Early-stage bone colonization by breast cancer.
We recently discovered that bone micrometastases of breast cancer predominantly reside in the microenvironment termed the "osteogenic niche". The heterotypic adherens junctions between cancer cells and osteogenic cells promote early-stage bone colonization by activating the mTOR pathway in cancer cells. Here, we discuss a few questions raised by these findings.
Lester and Sue Smith Breast Center; Baylor College of Medicine; Houston, TX USA; Department of Molecular and Cellular Biology; Baylor College of Medicine; Houston, TX USA.
Hai
H
Wang
Lester and Sue Smith Breast Center; Baylor College of Medicine; Houston, TX USA; Department of Molecular and Cellular Biology; Baylor College of Medicine; Houston, TX USA.
Cuijuan
C
Yu
Lester and Sue Smith Breast Center; Baylor College of Medicine; Houston, TX USA; Department of Molecular and Cellular Biology; Baylor College of Medicine; Houston, TX USA; Dan L. Duncan Cancer Center; Baylor College of Medicine; Houston, TX USA; McNair Medical Institute; Baylor College of Medicine; Houston, TX USA.
Xiang H F
XH
Zhang
bone micrometastasis; colonization of disseminated breast cancer cells; heterotypic adherens junctions; mTOR pathway; osteogenic niche