Diastereoselective Synthesis of CF3- and CF2H-Substituted Spiroethers from Aryl-Fused Cycloalkenylalkanols by Photoredox Catalysis.
Simple synthesis of CF3- and CF2H-spiroethers from aryl-fused cycloalkenylalkanols by photoredox catalysis has been developed. Modification of the fluoromethylating reagents and the photoredox catalysts leads to both CF3- and CF2H-spiroetherification. The present photocatalytic system allows us to access a variety of new anti-fluoromethylated spiroethers in a highly selective manner.
Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology R1-27, 4259 Nagatsuta, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Naoki
N
Noto
Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology R1-27, 4259 Nagatsuta, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Takashi
T
Koike
Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology R1-27, 4259 Nagatsuta, Midori-ku, Yokohama, Kanagawa 226-8503, Japan.
Munetaka
M
Akita