Dissolution Rate Enhancement of Repaglinide Using Dietary Fiber as a Promising Carrier.
In present investigation, an innovative attempt has been made to enhance the solubility and dissolution rate of Repaglinide (RPGD) using hydrothermally treated water insoluble dietary bamboo fibers (HVBF) as potential nutraceutical used in the treatment of diabetes mellitus. RPGD was selected as a model drug due to its low aqueous solubility and dissolution rate. Characterization of HVBF demonstrated the outstanding features like high surface area, maximum drug loading and increase dissolution rate and making HVBF as an excellent drug carrier. RHVBF (Repaglinide loaded HVBF) tablets were prepared using direct compression method. Pre and post-compression parameters for blend and tablets were studied and found within acceptable limits. RHVBF and tablet showed significantly improved dissolution rate, when compared with pure crystalline RPGD, physical mixture, RVBF and commercial marketed tablet. This fact was further supported by FT-IR, DSC, XRPD and FESEM studies followed by in-vitro drug release profile. Stability studies showed no changes after exposing to accelerated conditions for a period of 3 months with respect to physical characteristics and in-vitro drug release studies. In a nut shell, it can be concluded that HVBF is a novel, smart and promising carrier for poorly water soluble drugs, when administered orally.
Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist-Dhule, Maharashtra 425405, India. chatap@rediffmail.com.
Vivekanand K
VK
Chatap
Savita D
SD
Patil
D002219:Carbamates / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D002482:Cellulose / Q000737:chemistry*; D055598:Chemical Phenomena; D004043:Dietary Fiber / Q000008:administration & dosage*; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry*; D065546:Drug Liberation; D004355:Drug Stability; D066298:In Vitro Techniques; D010880:Piperidines / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D031787:Sasa / Q000737:chemistry; D012995:Solubility; D013607:Tablets
D002219:Carbamates; D004043:Dietary Fiber; D004337:Drug Carriers; D010880:Piperidines; D013607:Tablets; C118049:vitacel M80K; C072379:repaglinide; D002482:Cellulose