Rationale for local treatment in the management of metastatic prostate cancer.
To evaluate the rationale supporting the role of local treatment in the management of patients with metastatic prostate cancer (PCa).



Not all patients with metastatic PCa share the same prognosis, in which selected individuals with oligometastatic PCa might benefit from local therapies. These men would harbor a biologically different disease as compared with their counterparts with widespread metastases. Local treatment would eliminate the source of tumor-promoting factors, destroy the origin of metastatic cells, and stop the self-seeding process. Moreover, decreasing tumor burden would eventually allow for an improved response to systemic therapies. Recent clinical studies support an oncologic role of surgery or radiotherapy in metastatic PCa. However, their retrospective nature limits the relevance of these findings. Results of ongoing trials assessing the impact of local treatment in metastatic patients are needed to comprehensively address its role.



Preclinical observations provide a rationale for treatment of the primary tumor in selected patients with metastatic PCa. However, available clinical evidence comes from retrospective investigations, and only results of ongoing randomized trials would clarify the role of local treatment in the metastatic setting.
aDivision of Oncology/Unit of Urology; URI; IRCCS Ospedale San Raffaele, Milan, Italy bVita-Salute San Raffaele University, Milan, Italy cOLV Vattikuti Robotic Surgery Institute, Melle, Belgium dUrology Department, University of Naples Federico II, Naples, Italy.
Giorgio
G
Gandaglia
Nicola
N
Fossati
Paolo
P
Dell'Oglio
Marco
M
Moschini
Vito
V
Cucchiara
Nazareno
N
Suardi
Alexandre
A
Mottrie
Vincenzo
V
Mirone
Francesco
F
Montorsi
Alberto
A
Briganti
D016207:Cytokines / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D011379:Prognosis; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D011878:Radiotherapy / Q000379:methods
D016207:Cytokines