PET Imaging of Skeletal Metastases and Its Role in Personalizing Further Management.
In oncology, the skeleton is one of the most frequently encountered sites for metastatic disease and thus early detection not only has an impact on an individual patient's management but also on the overall outcome. Multiparametric and multimodal hybrid PET/computed tomography and PET/MR imaging have revolutionized imaging for bone metastases, but irrespective of tumor biology or morphology of the bone lesion it remains unclear which imaging modality is the most clinically relevant to guide individualized cancer care. In this review, we highlight the current clinical challenges of PET imaging in evaluation and quantification of skeletal tumor burden and its impact on personalized cancer management.
Department of Radiodiagnosis, Tata Memorial Hospital, Parel, Mumbai 400012, India.
Abhishek
A
Mahajan
Division of Imaging Sciences and Biomedical Engineering, Cancer Imaging Department, King's College London, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK.
Gurdip Kaur
GK
Azad
Division of Imaging Sciences and Biomedical Engineering, Cancer Imaging Department, King's College London, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK; Clinical PET Centre, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, UK. Electronic address: gary.cook@kcl.ac.uk.
Gary J
GJ
Cook
D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D057285:Precision Medicine / Q000379:methods*
Bone; Evidence based medicine; Functional imaging; Neoplasms/Carcinoma; Radionuclide imaging; Skeletal metastasis; Translational medicine; Tumor biology