The mouse cortico-striatal projectome.
Different cortical areas are organized into distinct intracortical subnetworks. The manner in which descending pathways from the entire cortex interact subcortically as a network remains unclear. We developed an open-access comprehensive mesoscale mouse cortico-striatal projectome: a detailed connectivity projection map from the entire cerebral cortex to the dorsal striatum or caudoputamen (CP) in rodents. On the basis of these projections, we used new computational neuroanatomical tools to identify 29 distinct functional striatal domains. Furthermore, we characterized different cortico-striatal networks and how they reconfigure across the rostral-caudal extent of the CP. The workflow was also applied to select cortico-striatal connections in two different mouse models of disconnection syndromes to demonstrate its utility for characterizing circuitry-specific connectopathies. Together, our results provide the structural basis for studying the functional diversity of the dorsal striatum and disruptions of cortico-basal ganglia networks across a broad range of disorders.
USC Stevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging (LONI), Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Houri
H
Hintiryan
USC Stevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging (LONI), Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Nicholas N
NN
Foster
USC Stevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging (LONI), Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Ian
I
Bowman
USC Stevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging (LONI), Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Maxwell
M
Bay
USC Stevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging (LONI), Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Monica Y
MY
Song
USC Stevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging (LONI), Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Lin
L
Gou
USC Stevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging (LONI), Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Seita
S
Yamashita
USC Stevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging (LONI), Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Michael S
MS
Bienkowski
Zilkha Neurogenetic Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Brian
B
Zingg
USC Stevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging (LONI), Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Muye
M
Zhu
Center for Neurobehavioral Genetics, Semel Institute for Neuroscience &Human Behavior, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
X William
XW
Yang
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA.
Jean C
JC
Shih
USC Stevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging (LONI), Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Arthur W
AW
Toga
USC Stevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging (LONI), Keck School of Medicine of University of Southern California, Los Angeles, California, USA.|Zilkha Neurogenetic Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.|Department of Neurology, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Hong-Wei
HW
Dong
D000818:Animals; D001479:Basal Ganglia / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D008297:Male; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D009434:Neural Pathways / Q000502:physiology*