WWOX guards genome stability by activating ATM.
Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be "hot spots" for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates with ataxia telangiectasia-mutated (ATM) and regulates its activation to maintain genomic integrity.
The Lautenberg Center for General and Tumor Immunology; Department of Immunology and Cancer Research-IMRIC; Hebrew University-Hadassah Medical School ; Jerusalem, Israel.
Idit
I
Hazan
The Lautenberg Center for General and Tumor Immunology; Department of Immunology and Cancer Research-IMRIC; Hebrew University-Hadassah Medical School ; Jerusalem, Israel.
Mohammad
M
Abu-Odeh
German Cancer Research Center (DKFZ); Cellular Senescence Group; DKFZ-ZMBH Alliance ; Heidelberg, Germany.
Thomas G
TG
Hofmann
The Lautenberg Center for General and Tumor Immunology; Department of Immunology and Cancer Research-IMRIC; Hebrew University-Hadassah Medical School ; Jerusalem, Israel.
Rami I
RI
Aqeilan