Gender, Contraceptives and Individual Metabolic Predisposition Shape a Healthy Plasma Lipidome.
Lipidomics of human blood plasma is an emerging biomarker discovery approach that compares lipid profiles under pathological and physiologically normal conditions, but how a healthy lipidome varies within the population is poorly understood. By quantifying 281 molecular species from 27 major lipid classes in the plasma of 71 healthy young Caucasians whose 35 clinical blood test and anthropometric indices matched the medical norm, we provided a comprehensive, expandable and clinically relevant resource of reference molar concentrations of individual lipids. We established that gender is a major lipidomic factor, whose impact is strongly enhanced by hormonal contraceptives and mediated by sex hormone-binding globulin. In lipidomics epidemiological studies should avoid mixed-gender cohorts and females taking hormonal contraceptives should be considered as a separate sub-cohort. Within a gender-restricted cohort lipidomics revealed a compositional signature that indicates the predisposition towards an early development of metabolic syndrome in ca. 25% of healthy male individuals suggesting a healthy plasma lipidome as resource for early biomarker discovery.
MPI of Molecular Cell Biology and Genetics, Pfotenhauerstrstraße 108, 01307 Dresden, Germany.
Susanne
S
Sales
Department of Internal Medicine III, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.
Juergen
J
Graessler
Biomedical Cybernetics Group, Biotechnology Center (BIOTEC), Technische Universität Dresden, Tatzberg 47/49, 01307 Dresden, Germany.|Lipotype GmbH, Tatzberg 47, 01307 Dresden, Germany.
Sara
S
Ciucci
Department of Internal Medicine III, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.
Rania
R
Al-Atrib
Zora Biosciences Oy Biologinkuja 1, 02150 Espoo, Finland.
Terhi
T
Vihervaara
MPI of Molecular Cell Biology and Genetics, Pfotenhauerstrstraße 108, 01307 Dresden, Germany.
Kai
K
Schuhmann
Zora Biosciences Oy Biologinkuja 1, 02150 Espoo, Finland.
Dimple
D
Kauhanen
Zora Biosciences Oy Biologinkuja 1, 02150 Espoo, Finland.
Marko
M
Sysi-Aho
Department of Internal Medicine III, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.|Division of Diabetes &Nutritional Sciences, King's College Hospital, NHS Foundation Trust, London, SE5 9RS, UK.
Stefan R
SR
Bornstein
MPI of Molecular Cell Biology and Genetics, Pfotenhauerstrstraße 108, 01307 Dresden, Germany.
Marc
M
Bickle
Biomedical Cybernetics Group, Biotechnology Center (BIOTEC), Technische Universität Dresden, Tatzberg 47/49, 01307 Dresden, Germany.
Carlo V
CV
Cannistraci
Zora Biosciences Oy Biologinkuja 1, 02150 Espoo, Finland.
Kim
K
Ekroos
MPI of Molecular Cell Biology and Genetics, Pfotenhauerstrstraße 108, 01307 Dresden, Germany.
Andrej
A
Shevchenko
D003270:Contraceptive Agents / Q000494:pharmacology*; D004198:Disease Susceptibility; D050171:Dyslipidemias / Q000097:blood; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D055442:Metabolome; D015999:Multivariate Analysis; D025341:Principal Component Analysis; D015203:Reproducibility of Results; D012727:Sex Characteristics; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism
D003270:Contraceptive Agents; D008055:Lipids; D012738:Sex Hormone-Binding Globulin