Pumilio and nanos RNA-binding proteins counterbalance the transcriptional consequences of RB1 inactivation.
The ability of the retinoblastoma protein (RB) tumor suppressor to repress transcription stimulated by the E2 promoter binding factors (E2F) is integral to its biological functions. Our recent report described a conserved feedback mechanism mediated by the RNA-binding proteins Pumilio and Nanos that increases in importance following RB loss and helps cells to tolerate deregulated E2F.
Massachusetts General Hospital Cancer Center and Harvard Medical School ; Charlestown, MA USA.
Wayne O
WO
Miles
Massachusetts General Hospital Cancer Center and Harvard Medical School ; Charlestown, MA USA.
Nicholas J
NJ
Dyson
NANOS; PUMILIO; RB1; RNA; cancer; p53; post-transcriptional regulation; retinoblastoma