7,7-Dimethylaporphine and Other Alkaloids from the Bark of Guatteria friesiana.
Phytochemical investigation of the bark of Guatteria friesiana afforded 12 new aporphines (1-12), along with nine known alkaloids (13-21). The structures of the new alkaloids were determined on the basis of spectroscopic data interpretation. The cytotoxic activity of the isolated compounds against a small panel of tumor cell lines was assessed using the Alamar blue assay.
Department of Chemistry, Federal University of Amazonas , Manaus 69077-000, Brazil.
Emmanoel V
EV
Costa
Department of Chemistry, Federal University of Amazonas , Manaus 69077-000, Brazil.
Maria Lúcia B
ML
Pinheiro
Department of Chemistry, Federal University of Paraná , Curitiba 81531-990, Brazil.
Beatriz Helena L N S
BH
Maia
Department of Chemistry, Federal University of Paraná , Curitiba 81531-990, Brazil.
Francisco A
FA
Marques
Chemical, Biological and Agricultural Pluridisciplinary Research Center/CPQBA, University of Campinas , Paulínia 13083-970, Brazil.
Ana Lúcia T G
AL
Ruiz
Chemical, Biological and Agricultural Pluridisciplinary Research Center/CPQBA, University of Campinas , Paulínia 13083-970, Brazil.
Gabriela M
GM
Marchetti
Chemical, Biological and Agricultural Pluridisciplinary Research Center/CPQBA, University of Campinas , Paulínia 13083-970, Brazil.
João Ernesto de
JE
Carvalho
Gonçalo Moniz Research Center, Oswaldo Cruz Foundation/CPqGM-FIOCRUZ , Salvador 40296-710, Brazil.|Biotechnology and Cell Therapy Center, São Rafael Hospital , Salvador 41253-190, Brazil.
Milena B P
MB
Soares
Gonçalo Moniz Research Center, Oswaldo Cruz Foundation/CPqGM-FIOCRUZ , Salvador 40296-710, Brazil.
Cinara O S
CO
Costa
Gonçalo Moniz Research Center, Oswaldo Cruz Foundation/CPqGM-FIOCRUZ , Salvador 40296-710, Brazil.
Alexandre F C
AF
Galvão
Department of Chemistry and Physics, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo , Ribeirão Preto 14040-903, Brazil.
Norberto P
NP
Lopes
DeMpSter Mass Spectrometry Group, Amazonas State University , Manaus 69050-010, Brazil.
Hector H F
HH
Koolen
Gonçalo Moniz Research Center, Oswaldo Cruz Foundation/CPqGM-FIOCRUZ , Salvador 40296-710, Brazil.
Daniel P
DP
Bezerra
Department of Chemistry, Federal University of Paraná , Curitiba 81531-990, Brazil.
Andersson
A
Barison
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001060:Aporphines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D004354:Drug Screening Assays, Antitumor; D031043:Guatteria / Q000737:chemistry*; D018922:HL-60 Cells; D056945:Hep G2 Cells; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry*
C000618512:7,7-dimethylaporphine; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines