FLCN: A new regulator of AMPK-dependent Warburg metabolic reprogramming.
Tumor cells manage their energy to support aberrant proliferation by reprogramming their cellular metabolism, for example through the Warburg effect. Although AMPK is a major regulator of energy homeostasis, its role in cancer metabolic adaptation is unclear. We recently identified the tumor suppressor folliculin as a new regulator of AMPK-dependent metabolic transformation.
Goodman Cancer Research Center; McGill University; Montréal, QC Canada; Department of Biochemistry; McGill University; Montréal, QC Canada.
Marie-Claude
MC
Gingras
Goodman Cancer Research Center; McGill University; Montréal, QC Canada; Department of Biochemistry; McGill University; Montréal, QC Canada.
Arnim
A
Pause
AMPK; HIF; PGC-1α; ROS; Warburg effect; folliculin; glycolysis; metabolic adaptation; oxidative phosphorylation