Porcine cancer models for translational oncology.
Large-animal cancer models are needed to advance the development of innovative and clinically applicable tumor diagnostic, therapeutic, and monitoring technologies. We developed a genetically modified porcine model of cancer based on a TP53 mutation, and established its utility for tracking tumorigenesis in vivo through non-invasive clinical imaging approaches.
Radiology and Biomedical Engineering; University of Iowa; Iowa City, IA USA; Holden Comprehensive Cancer Center; University of Iowa; Iowa City, IA USA.
Jessica C
JC
Sieren
Holden Comprehensive Cancer Center; University of Iowa; Iowa City, IA USA; Pharmacology; University of Iowa; Iowa City, IA USA; Pathology, University of Iowa; Iowa City, IA USA.
Dawn
D
Quelle
Pathology, University of Iowa ; Iowa City, IA USA.
David K
DK
Meyerholz
Exemplar Genetics; Sioux Center ; IA USA.
Christopher S
CS
Rogers