Tissue-inappropriate derepression of FOXC1 is frequent and functional in human acute myeloid leukemia.
Tissue-inappropriate derepression of the mesenchymal transcription factor gene Forkhead Box C1 (FOXC1) occurs in approximately 20% of patients with acute myeloid leukemia. Through experimental and bioinformatics analyses, we have demonstrated this to be both functional (enhancing the myeloid lineage differentiation block characteristic of the disease) and adversely prognostic.
Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester , Manchester, M20 4BX, United Kingdom.
Tim D D
TD
Somerville
Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester , Manchester, M20 4BX, United Kingdom.
Tim C P
TC
Somervaille
Acute myeloid leukemia; FOXC1; Polycomb