Cyclosporine in Dermatology.
Cyclosporine, a member of the calcineurin inhibitor family, has immunomodulatory effects on T cells. It blocks the earliest stages of the immune response by binding to cyclophilin, thus inhibiting calcineurin. It was initially used for transplant patients to prevent transplant rejections. The main indication for cyclosporine in dermatology is severe psoriasis. Other dermatologic indications for the use of cyclosporine include atopic dermatitis, chronic idiopathic urticaria, pyoderma gangrenosum, and Behçet's disease.
Department of Dermatology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey; zekayikutlubay@hotmail.com.
Zekayi
Z
Kutlubay
Department of Dermatology, Sadi Konuk Research and Training Hospital, Istanbul, Turkey.
Bigen Çakıl
BÇ
Erdogan
Department of Dermatology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey.
Burhan
B
Engin
Department of Dermatology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey.
Server
S
Serdaroglu
D001528:Behcet Syndrome / Q000188:drug therapy; D016572:Cyclosporine / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000188:drug therapy; D003879:Dermatologic Agents / Q000627:therapeutic use*; D003880:Dermatology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D011565:Psoriasis / Q000188:drug therapy; D017511:Pyoderma Gangrenosum / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy*; D014581:Urticaria / Q000188:drug therapy
D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine