Advances in the synthesis of α-quaternary α-ethynyl α-amino acids.
α-Quaternary α-ethynyl α-amino acids are an important class of non-proteinogenic amino acids that play an important role in the development of peptides and peptidomimetics as therapeutic agents and in the inhibition of enzyme activities. This review provides an overview of the literature concerning synthesis and applications of α-quaternary α-ethynyl α-amino acids covering the period from 1977 to 2015.
Univ. Nimes, EA7352 CHROME, Rue du Dr G. Salan, 30021, Nîmes Cedex 1, France.
Thibaut
T
Boibessot
Univ. Nimes, EA7352 CHROME, Rue du Dr G. Salan, 30021, Nîmes Cedex 1, France.
David
D
Bénimélis
Univ. Nimes, EA7352 CHROME, Rue du Dr G. Salan, 30021, Nîmes Cedex 1, France.
Patrick
P
Meffre
Univ. Nimes, EA7352 CHROME, Rue du Dr G. Salan, 30021, Nîmes Cedex 1, France. zohra.benfodda@unimes.fr.
Zohra
0000-0001-7574-4977
Z
Benfodda
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*
D000596:Amino Acids; D010455:Peptides
Quaternary amino acid; Unsaturated amino acid; α-Quaternary α-ethynyl α-amino acids