Diffusion Processes and Drug Release: Capsaicinoids - Loaded Poly (ε-caprolactone) Microparticles.
We present a generalmodel based on fractional diffusion equation coupled with a kinetic equation through the boundary condition. It covers several scenarios that may be characterized by usual or anomalous diffusion or present relaxation processes on the surface with non-Debye characteristics. A particular case of this model is used to investigate the experimental data obtained from the drug release of the capsaicinoids-loaded Poly (ε-caprolactone) microparticles. These considerations lead us to a good agreement with experimental data and to the conjecture that the burst effect, i.e., an initial large bolus of drug is released before the release rate reaches a stable profile, may be related to an anomalous diffusion manifested by the system.
Departamento de Física, Universidade Estadual de Ponta Grossa, Ponta Grossa, 84030-900, Brazil.
E K
EK
Lenzi
Departamento de Física, Universidade Estadual de Ponta Grossa, Ponta Grossa, 84030-900, Brazil.
A
A
Novatski
Departamento de Ciências Farmacêuticas, Universidade Estadual de Ponta Grossa,Ponta Grossa, 84030-900, Brazil.
P V
PV
Farago
Departamento Química, Universidade Federal de Curitiba, Curitiba, 81531-980, Brazil.
M A
MA
Almeida
Departamento Química, Universidade Federal de Curitiba, Curitiba, 81531-980, Brazil.
S F
SF
Zawadzki
Departamento de Física, Universidade Estadual de Ponta Grossa, Ponta Grossa, 84030-900, Brazil.
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R
Menechini Neto
D002396:Catechols / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D007700:Kinetics; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D012991:Solanaceous Alkaloids / Q000737:chemistry*
D002396:Catechols; D004337:Drug Carriers; D011091:Polyesters; D012991:Solanaceous Alkaloids; C016240:polycaprolactone