2015 Homer W. Smith Award: The Podocyte from Periphery to Center Stage.
This overview summarizes selected major developments over the last 40 years in understanding podocyte biology and its involvement in glomerular disease subjectively from my perspective. Serendipity has played a major role in my contributions to investigative nephrology that range from basic mechanisms of immune deposit formation in experimental membranous nephropathy to the role of a microRNA in FSGS. This review emphasizes the importance of continuous reality checks of experimental results obtained in vitro or with genetically modified animals with human disease.
Clinical Department of Pathology, Medical University of Vienna, Vienna, Austria dontscho.kerjaschki@meduniwien.ac.at.
Dontscho
D
Kerjaschki
D000818:Animals; D001363:Awards and Prizes; D015433:Glomerulonephritis, Membranous / Q000209:etiology; D006801:Humans; D035683:MicroRNAs / Q000502:physiology; D050199:Podocytes / Q000502:physiology*
C546818:MIRN193 microRNA, human; D035683:MicroRNAs
Homer Smith; focal segmental glomerulosclerosis; kidney disease; microRNAs; nephrology; podocyte