Harnessing gene and drug delivery for vascularizing engineered tissue platforms.
Enhancement of tissue vascularization is a therapeutic target for many ischemic conditions, and is crucial for successful engraftment of therapeutic cells for tissue regeneration. The authors present opportunities for using these platforms for dissecting the role of angiogenic mechanisms and highlight recent gene and drug delivery strategies for enhancing vascularization of engineered tissues. Modular tissue engineering is featured as an example.
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
Gabrielle C
GC
Lam
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada. Electronic address: michael.sefton@utoronto.ca.
Michael V
MV
Sefton
D000818:Animals; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D006801:Humans; D018919:Neovascularization, Physiologic / Q000235:genetics; D023822:Tissue Engineering