Multiple roles for the hippo effector yap in gut regeneration and cancer initiation.
The Hippo signaling effector Yes-associated protein (Yap) is known for its potent control of tissue growth. Our recent work now shows that Yap promotes regeneration in the intestine by reprogramming intestinal stem cells and blocking their terminal differentiation. Similarly, in tumor-initiating cells Yap regenerative signaling synergizes with Wnt activation to drive adenoma formation.
Centre for Systems Biology, and Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital , Toronto, Ontario, Canada.
Alex
A
Gregorieff
Centre for Systems Biology, and Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Ontario, Canada.
Jeffrey L
JL
Wrana
Egfr; Paneth cells; Wnt; Yap; hippo; intestinal stem cells