Preventing preeclampsia and its fetal complications with low-dose aspirin in East Asians and non-East Asians:A systematic review and meta-analysis.
BACKGROUND
Low-dose aspirin can reduce the incidence of preeclampsia and intrauterine growth restriction (IUGR). However, the effects of ethnicity upon low-dose aspirin's efficacy has not been analyzed. Here, we comparatively evaluated the efficacy of low-dose aspirin in preventing preeclampsia and related fetal complications in East Asian and non-East Asian pregnant women at risk for preeclampsia.


METHODS
Several databases were searched for randomized controlled trials (RCTs) comparing low-dose aspirin with either placebo or no treatment in pregnant women at risk for preeclampsia. Odds ratios (ORs) and associated 95% confidence intervals (CIs) for preeclampsia and related fetal outcomes were tabulated.


RESULTS
Low-dose aspirin significantly reduced preeclampsia risk in both East Asians (OR = 0.20, 95% CI: 0.11-0.35) and non-East Asians (OR = 0.84, 95% CI: 0.77-0.92). Low-dose aspirin significantly reduced IUGR risk in East Asians (OR = 0.36, 95% CI: 0.20-0.67) but not in non-East Asians (OR = 0.85, 95% CI: 0.41-1.77). Low-dose aspirin did not significantly reduce the risk of cesarean section in either East Asians (OR = 0.67, 95% CI: 0.14-3.22) or non-East Asians (OR = 1.01, 95% CI: 0.86-1.19).


CONCLUSIONS
Low-dose aspirin is effective in reducing preeclampsia risk in both East Asians and non-East Asians and has differential effects in East Asians and non-East Asians with respect to IUGR.
a Department of Obstetrics and Gynecology , The First Affiliated Hospital of Chongqong Medical University , Yuzhong , Chongqing , P. R. China.
Jie
J
Gan
a Department of Obstetrics and Gynecology , The First Affiliated Hospital of Chongqong Medical University , Yuzhong , Chongqing , P. R. China.
Huan
H
He
a Department of Obstetrics and Gynecology , The First Affiliated Hospital of Chongqong Medical University , Yuzhong , Chongqing , P. R. China.
Hongbo
H
Qi
D044466:Asian People; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005317:Fetal Growth Retardation / Q000208:ethnology / Q000517:prevention & control*; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000208:ethnology / Q000517:prevention & control*; D011247:Pregnancy
D010975:Platelet Aggregation Inhibitors; D001241:Aspirin
Acetylsalicylic acid; Asian; IUGR; aspirin; intrauterine growth restriction; preeclampsia