Is Xanthine oxidase activity in polycystic ovary syndrome associated with inflammatory and cardiovascular risk factors?
The aim of this study is to examine women with polycystic ovary syndrome (PCOS) to determine the relationship between xanthine oxidase (XO) and oxidative stress, inflammatory status, and various clinical and biochemical parameters. In this cross-sectional study a total of 83 women including 45 PCOS patients and 38 healthy women were enrolled. We collected blood samples for XO and superoxide dismutase (SOD) activity, hormone levels, cholesterol values, and inflammatory markers. Body mass index (BMI) , waist-to-hip ratio (WHR), and blood pressure were assessed. Blood samples were taken for hormonal levels, cholesterol levels, fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostatic model assessment-insulin resistance (HOMA-IR) index, quantitative insulin sensitivity check index (QUICKI), C-reactive protein (CRP), white blood cell and neutrophil counts, XO and SOD activities. The basal hormone levels, triglyceride (TG) levels, TG/HDL-C (high density lipoprotein-cholesterol) ratios FPG, FPI and HOMA-IR levels were higher in PCOS patients compared to controls (p<0.05). Platelet and plateletcrit (PCT) values, CRP, and XO activity were significantly increased, however SOD activity was decreased in PCOS patients (p<0.001). XO activity was positively correlated with LH/FSH and TG/HDL ratios, CRP, PCT, FPG, FPI, and HOMA-IR, and negatively correlated with QUICKI levels. In conclusion, XO is a useful marker to assess oxidative stress in PCOS patients. Positive correlations between XO and inflammatory markers and cardiovascular disease risk factors suggest that XO plays an important role in the pathogenesis of PCOS and its metabolic complications.
Bulent Ecevit University School of Medicine, Obstetrics and Gynecology Department, Zonguldak, Turkey; MevlanaUniversity School of Medicine, Obstetrics and Gynecology Department, Konya, Turkey. Electronic address: k.hgonbe@gmail.com.
Hatice
H
Isık
Bulent Ecevit University School of Medicine, Obstetrics and Gynecology Department, Zonguldak, Turkey.
Oner
O
Aynıoglu
Zekai Tahir Burak Women's Health Center, Obstetrics and Gynecology Department, Ankara, Turkey.
Hakan
H
Tımur
Bulent Ecevit University School of Medicine, Obstetrics and Gynecology Department, Zonguldak, Turkey.
Ahmet
A
Sahbaz
Bulent Ecevit University School of Medicine, Obstetrics and Gynecology Department, Zonguldak, Turkey.
Muge
M
Harma
Bulent Ecevit University School of Medicine, Biochemistry Department, Zonguldak, Turkey.
Murat
M
Can
Bulent Ecevit University School of Medicine, Biochemistry Department, Zonguldak, Turkey.
Berrak
B
Guven
MevlanaUniversity School of Medicine, Obstetrics and Gynecology Department, Konya, Turkey.
Husnu
H
Alptekin
Bulent Ecevit University School of Medicine, Biostatistics Department, Zonguldak, Turkey.
Furuzan
F
Kokturk
D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000175:diagnosis*; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000378:metabolism; D007328:Insulin / Q000097:blood; D018384:Oxidative Stress; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis*; D011379:Prognosis; D012306:Risk; D013482:Superoxide Dismutase / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D014969:Xanthine Oxidase / Q000378:metabolism*; D055815:Young Adult
D015415:Biomarkers; D001786:Blood Glucose; D006728:Hormones; D007328:Insulin; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase
Cardiovascular risk; Inflammation; PCOS; Xanthine oxidase activity