β-Adrenoreceptor agonists in the management of pain associated with renal colic: a systematic review.
To determine whether β-adrenoreceptor agonists are effective analgesics for patients with renal colic through a systematic review of the literature.



Adult emergency departments or acute assessment units.



Human participants with proven or suspected renal colic.



β-adrenoreceptor agonists.



Primary: level of pain at 30 min following administration of the β-agonist. Secondary: level of pain at various time points following β-agonist administration; length of hospital stay; analgesic requirement; stone presence, size and position; degree of hydronephrosis.



256 records were screened and 4 identified for full-text review. No articles met the inclusion criteria.



There is no evidence to support or refute the proposed use of β-agonists for analgesia in patients with renal colic. Given the biological plausibility and existing literature base, clinical trials investigating the use of β-adrenoreceptor agonists in the acute setting for treatment of the pain associated with renal colic are recommended.



CRD42015016266.
Emergency Department, Royal Derby Hospital, Derby, UK.
Andrew John
0000-0003-4191-9024
AJ
Tabner
Emergency Department, Royal Derby Hospital, Derby, UK.
Graham David
GD
Johnson
Research and Development Department, Derby Teaching Hospitals NHS Foundation Trust, Derby, UK.
Apostolos
A
Fakis
Research and Development Department, Derby Teaching Hospitals NHS Foundation Trust, Derby, UK.
Jane
J
Surtees
Emergency Department, Royal Derby Hospital, Derby, UK.
Robert Iain
RI
Lennon
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use*; D004632:Emergency Medical Services; D006801:Humans; D010146:Pain / Q000209:etiology; D059408:Pain Management; D056844:Renal Colic / Q000188:drug therapy*; D013997:Time Factors
D000318:Adrenergic beta-Agonists; D000700:Analgesics
ACCIDENT & EMERGENCY MEDICINE; PAIN MANAGEMENT; UROLOGY