Effects of Functional Groups and Sugar Composition of Quercetin Derivatives on Their Radical Scavenging Properties.
Quercetin derivatives are widespread in the plant kingdom and exhibit various biological actions. The aim of this study was to investigate the structure-activity relationships of quercetin derivatives, with a focus on the influence of functional groups and sugar composition on their antioxidant capacity. A series of quercetin derivatives were therefore prepared and assessed for their DPPH radical scavenging properties. Isoquercetin O-gallates were more potent radical scavengers than quercetin. The systematic analysis highlights the importance of the distribution of hydroxy substituents in isoquercetin O-gallates to their potency.
Department of Materials Science and Technology and ‡Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University , 1-1 Yanagido, Gifu 501-1193, Japan.|Division of Anaerobe Research, Life Science Research Center, and ⊥United Graduate School of Drug Discovery and Medicinal Information Sciences, Gifu University , 1-1 Yanagido, Gifu 501-1194, Japan.
Komei
K
Kato
Department of Materials Science and Technology and ‡Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University , 1-1 Yanagido, Gifu 501-1193, Japan.|Division of Anaerobe Research, Life Science Research Center, and ⊥United Graduate School of Drug Discovery and Medicinal Information Sciences, Gifu University , 1-1 Yanagido, Gifu 501-1194, Japan.
Masayuki
M
Ninomiya
Department of Materials Science and Technology and ‡Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University , 1-1 Yanagido, Gifu 501-1193, Japan.|Division of Anaerobe Research, Life Science Research Center, and ⊥United Graduate School of Drug Discovery and Medicinal Information Sciences, Gifu University , 1-1 Yanagido, Gifu 501-1194, Japan.
Kaori
K
Tanaka
Department of Materials Science and Technology and ‡Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University , 1-1 Yanagido, Gifu 501-1193, Japan.|Division of Anaerobe Research, Life Science Research Center, and ⊥United Graduate School of Drug Discovery and Medicinal Information Sciences, Gifu University , 1-1 Yanagido, Gifu 501-1194, Japan.
Mamoru
M
Koketsu
D000975:Antioxidants / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010851:Picrates / Q000494:pharmacology; D011794:Quercetin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D011794:Quercetin; C004931:1,1-diphenyl-2-picrylhydrazyl