A Case of Sorafenib-induced DRESS Syndrome in Hepatocelluar Carcinoma.
Sorafenib is currently the only targeted therapy available for advanced stage hepatocellular carcinoma (HCC). Cutaneous adverse events associated with sorafenib treatment include hand-foot skin reaction, but there has been no report of drug reaction (or rash) with eosinophilia and systemic symptoms (DRESS) syndrome. Here, we report a case of 72-year-old man with HCC and alcoholic liver cirrhosis who developed skin eruptions, fever, eosinophilia, and deteriorated hepatic and renal function under sorafenib treatment. He has since successfully recovered with conservative care.
Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Dong Kyun
DK
Kim
Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Sung Woo
SW
Lee
Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Hwa Seong
HS
Nam
Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Dong Sub
DS
Jeon
Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Na Rae
NR
Park
Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Young Hee
YH
Nam
Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Soo Keol
SK
Lee
Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Yang Hyun
YH
Baek
Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Sang Young
SY
Han
Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Sung Wook
SW
Lee
DRESS syndrome; Hepatocellular carcinoma; Sorafenib