Target Delivery of a Novel Antitumor Organoplatinum(IV)-Substituted Polyoxometalate Complex for Safer and More Effective Colorectal Cancer Therapy In Vivo.
An inactive organoplatinum(IV)-substituted polyoxometalate is developed as an efficient and nontoxic prodrug with significant potential for treating human colorectal cancers. Further encapsulation of Pt(IV) -PW11 with DSPE-PEG2000 nanoparticles (NPs) enables targeted delivery and controlled release of inactive prodrug. Such Pt(IV) -PW11 -DSPE-PEG2000 NPs are highly efficient in inhibiting cellular growth of HT29 cells and treating human colorectal cancer in mice, superior to classic cisplatin.
Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin, 150080, P. R. China.|School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, P. R. China.
Tiedong
T
Sun
School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, P. R. China.
Wei
W
Cui
Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin, 150080, P. R. China.
Mei
M
Yan
School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, P. R. China.
Geng
G
Qin
Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin, 150080, P. R. China.|School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, P. R. China.
Wei
W
Guo
Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin, 150080, P. R. China.|School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, P. R. China.
Hongxi
H
Gu
Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin, 150080, P. R. China. shaoqinliu@hit.edu.cn.
Shaoqin
S
Liu
School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, P. R. China. kigo@hit.edu.cn.
Qiong
Q
Wu
D000818:Animals; D000970:Antineoplastic Agents; D045744:Cell Line, Tumor; D002945:Cisplatin; D015179:Colorectal Neoplasms; D016503:Drug Delivery Systems; D006801:Humans; D051379:Mice; D053758:Nanoparticles; D011355:Prodrugs; D017973:Tungsten Compounds; D000099294:Polyoxometalates
D000970:Antineoplastic Agents; D002945:Cisplatin; D011355:Prodrugs; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates
antitumor activity; micelles; polyoxometalates; target delivery