Hepatitis B Virus X Protein and Hepatocarcinogenesis.
Chronic hepatitis B virus (HBV) infection is one of the most associated factors in hepatocarcinogenesis. HBV is able to integrate into the host genome and encode the multi-functional hepatitis B virus x protein (HBx). Although the mechanism between HBx and carcinogenesis is still elusive, recent studies have shown that HBx was able to influence various signaling pathways, as well as epigenetic and genetic processes. This review will examine and summarize recent literature about HBx's role in these various processes.
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore, Singapore. e0013040@u.nus.edu.|Department of Hepatobiliary &amp; Pancreas Surgery, The First Hospital, Jilin University, Changchun 130021, China. e0013040@u.nus.edu.
Shuaichen
S
Liu
Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, 169610 Singapore, Singapore. samanthakohsy@gmail.com.
Samantha S Y
SS
Koh
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore, Singapore. caroline_lee@nuhs.edu.sg.|Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, 169610 Singapore, Singapore. caroline_lee@nuhs.edu.sg.|NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 117456 Singapore, Singapore. caroline_lee@nuhs.edu.sg.|Duke-NUS Graduate Medical School, 169857 Singapore, Singapore. caroline_lee@nuhs.edu.sg.
Caroline G L
CG
Lee
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D044127:Epigenesis, Genetic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D054334:Viral Regulatory and Accessory Proteins
D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein
HBx protein; hepatocarcinogenesis; hepatocellular carcinoma