CD44 regulates Wnt signaling at the level of LRP6.
CD44 was recently identified as a positive feedback regulator of Wnt/β-catenin signaling. This regulation occurs at the level of low-density lipoprotein receptor-related protein 6 phosphorylation and membrane targeting. These findings broaden our understanding of the Wnt pathway activation process and open new perspectives for anti-CD44 therapies in diseases associated with Wnt induction, including colorectal cancer.
Karlsruhe Institute of Technology; Institute of Toxicology and Genetics ; Postfach , Karlsruhe, Germany.
Véronique
V
Orian-Rousseau
Karlsruhe Institute of Technology; Institute of Toxicology and Genetics ; Postfach , Karlsruhe, Germany.
Mark
M
Schmitt