When the guardian becomes the enemy: Targeting ATM in PTEN-deficient cancers.
Ataxia telangiectasia mutated (ATM) is an important signaling molecule in the DNA damage response and inhibitors of ATM are under clinical development. We identified a synthetic lethal interaction between ATM inhibition and phosphatase and tensin homolog (PTEN) loss that was the result of increased oxidative stress. Inhibition of ATM therefore represents a novel strategy to target PTEN-associated cancers.
Centre for Cancer Research and Cell Biology, Queens University Belfast, Northern Ireland; Almac Diagnostics, Craigavon, Northern Ireland.
Nuala
N
McCabe
Centre for Cancer Research and Cell Biology, Queens University Belfast, Northern Ireland; Almac Diagnostics, Craigavon, Northern Ireland.
Steven M
SM
Walker
Centre for Cancer Research and Cell Biology, Queens University Belfast, Northern Ireland; Almac Diagnostics, Craigavon, Northern Ireland.
Richard D
RD
Kennedy
ATM; DNA damage; DSB; PTEN; ROS