Biomonitoring of Mycotoxins in Human Breast Milk: Current State and Future Perspectives.
Human breast milk is considered as the best and ideal form of nutrition for infants. However, food contaminants such as mycotoxins, which may be transferred from maternal blood to milk, are poorly described. Mycotoxins are a major group of natural toxins frequently detected in foods. Here, we review the current state-of-the-art in the monitoring of mycotoxins in human breast milk, i.e., knowledge on occurrence, metabolism, and analytical assays utilized for their quantification. We highlight that most of the data captured to date have not been verified with the precision now capable utilizing LC-MS/MS and LC-HRMS approaches. One concern is that some studies may overestimate individual measures, and most cannot capture the patterns and levels of mycotoxin mixtures. We propose accurate assessment as a priority, especially for aflatoxins, fumonisins, ochratoxin A, zearalenone, and deoxynivalenol as well as their major metabolites. However, also so-called emerging toxins such as citrinin, the enniatins, beauvericin, aurofusarin, or Alternaria toxins should be considered to evaluate their potential relevance. Key requirements for analytical quality assurance are identified and discussed to guide future developments in this area. Moreover, research needs including investigations of lactational transfer rates, the role of human metabolism for bioactivation or detoxification, and an evaluation of potential combinatory effects of different mycotoxins are pointed out. It is hoped that LC-MS based multianalyte methods will enable more accurate, rapid and affordable human biomonitoring approaches that support informed decisions for maternal and infant health.
University of Vienna , Faculty of Chemistry, Department of Food Chemistry and Toxicology, Waehringerstraße 38, 1090 Vienna, Austria.|University of Natural Resources and Life Sciences, Vienna (BOKU) , Department IFA-Tulln, Konrad-Lorenz-Straße 20, 3430 Tulln, Austria.
Benedikt
B
Warth
University of Vienna , Faculty of Chemistry, Department of Food Chemistry and Toxicology, Waehringerstraße 38, 1090 Vienna, Austria.
Dominik
D
Braun
Department of Biosciences and Biotechnology, Babcock University , Ilishan Remo, Nigeria.|Partnership for Aflatoxin Control in Africa, Department of Rural Economy and Agriculture, African Union Commission , Addis Ababa, Ethiopia.
Chibundu N
CN
Ezekiel
Maryland Institute for Environmental Health, School of Public Health, University of Maryland , College Park, Maryland 20742, United States.
Paul C
PC
Turner
Leibniz-Research Centre for Working Environment and Human Factors (IfADo) , Ardeystraße 67, D-44139 Dortmund, Germany.
Gisela H
GH
Degen
University of Vienna , Faculty of Chemistry, Department of Food Chemistry and Toxicology, Waehringerstraße 38, 1090 Vienna, Austria.
Doris
D
Marko
D002853:Chromatography, Liquid; D004781:Environmental Exposure; D004784:Environmental Monitoring; D006801:Humans; D057230:Limit of Detection; D013058:Mass Spectrometry; D008895:Milk, Human / Q000737:chemistry*; D009183:Mycotoxins / Q000032:analysis*
D009183:Mycotoxins