Digital Evaluation of Orbital Cyst Associated with Microphthalmos: Characteristics and Their Relationship with Orbital Volume.
OBJECTIVE
To study the characteristics of orbital cyst associated with microphthalmos in a group of Chinese patients, and to analyze the relationship between orbital cyst and orbital volume.


METHODS
Cross-sectional comparative study.


METHODS
120 patients who were diagnosed as unilateral clinical blind microphthalmos, in which 20 patients had orbital cyst in the affected eye.


METHODS
Participants had computed tomography (CT) scan. CT images were analyzed with a computer-aided software.


METHODS
Volume and position of orbital cyst, microphthalmic to contralateral ratio (MCR) of orbital volume, height and depth and orbital rim displacement.


RESULTS
38.1% of the cysts located anterior to or at the equator of the globe, 75% of which located infratemporally and all of which were outside the muscle cone. Most (84.6%) of the posterior cysts were inside the muscle cone. The anterior cysts were larger than the posterior cysts (p = 0.005). MCR of orbital volume (p<0.001), height (p = 0.004) and width (p = 0.043) were significantly higher in patients with orbital cyst than controls. For patients with orbital cyst, larger cyst-plus-globe volume of the affected eye was associated with higher MCR of orbital volume (r = 0.630, p = 0.003). Patients with large cyst-plus-globe volume had higher MCR of orbital volume (p = 0.002), height (p = 0.014), width (p = 0.005) and depth (p = 0.002) and less displacement in inferior (p = 0.004) orbital rim, compared with patients with small cyst-plus-globe volume, but the differences between patients with small cyst-plus-globe volume and patients without cyst were not significant.


CONCLUSIONS
Microphthalmic eyes with large cyst-plus-globe volume showed better similarity with the contralateral eyes, comparing with microphthalmic eyes without orbital cyst or with small cyst-plus-globe volume. It suggested that the existence of orbital cysts (especially large cysts) in microphthalmic eyes might play a positive role in the orbital development.
Beijing Tongren Eye Center, Capital Medical University, Beijing, China.|Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.|Beijing Ophthalmology & Visual Science Key Lab, Capital Medical University, Beijing, China.
Ying
Y
Cui
Beijing Tongren Eye Center, Capital Medical University, Beijing, China.|Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.|Beijing Ophthalmology & Visual Science Key Lab, Capital Medical University, Beijing, China.
Yue
Y
Zhang
Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Qinglin
Q
Chang
Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Junfang
J
Xian
Beijing Tongren Eye Center, Capital Medical University, Beijing, China.|Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.|Beijing Ophthalmology & Visual Science Key Lab, Capital Medical University, Beijing, China.
Zhijia
Z
Hou
Beijing Tongren Eye Center, Capital Medical University, Beijing, China.|Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.|Beijing Ophthalmology & Visual Science Key Lab, Capital Medical University, Beijing, China.
Dongmei
D
Li
D000293:Adolescent; D000328:Adult; D001766:Blindness / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D002681:China; D003560:Cysts / Q000000981:diagnostic imaging / Q000503:physiopathology; D005123:Eye / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008850:Microphthalmos / Q000175:diagnosis* / Q000503:physiopathology; D009915:Orbit / Q000000981:diagnostic imaging / Q000503:physiopathology; D009916:Orbital Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology; D014057:Tomography, X-Ray Computed