Peripheral nerve high-resolution ultrasound in diabetes.
High-resolution ultrasound (HRU) is used in the diagnosis of peripheral neuropathies. There are conflicting data regarding HRU findings in patients with diabetic sensorimotor polyneuropathy (DSP). Our purpose in this study was to measure nerve cross-sectional areas (CSAs) in patients with diabetes, with and without DSP.



We performed a prospective peripheral nerve HRU study of 100 diabetic subjects, assessed the CSA at predefined sites, and compared the results with those of 100 normal subjects. We evaluated the use of individual CSA values and various summary scores for diagnosis of DSP.



Diabetic subjects had higher CSA values than healthy volunteers, and those with DSP had higher CSA values. Three or more enlarged CSA sites predicted DSP with 64% sensitivity and 77% specificity.



Peripheral nerves are enlarged diffusely in diabetic patients, including sites not susceptible to bony compression. The number of enlarged CSA values can help predict the presence of DSP. Muscle Nerve, 2016 Muscle Nerve 55: 171-178, 2017.
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada.
Ari
A
Breiner
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada.|King Fahad Hospital, Ministry of Health, Madina, Saudi Arabia.
Mohammad
M
Qrimli
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Hamid
H
Ebadi
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada.|Department of Neurology, King Fahad University Hospital, University of Dammam, Dammam, Saudi Arabia.
Majed
M
Alabdali
Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital and Lunenfeld-Tanenbaum Research Institute, University of Toronto, Toronto, Ontario, Canada.
Leif E
LE
Lovblom
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada.
Alon
A
Abraham
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada.
Hana
H
Albulahi
Division of Endocrinology and Metabolism, Department of Medicine, Mount Sinai Hospital and Lunenfeld-Tanenbaum Research Institute, University of Toronto, Toronto, Ontario, Canada.
Bruce A
BA
Perkins
Ellen and Martin Prosserman Centre for Neuromuscular Diseases, Department of Medicine, 5EC-309, Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada.
Vera
V
Bril
D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000000981:diagnostic imaging* / Q000473:pathology*; D003929:Diabetic Neuropathies / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010525:Peripheral Nerves / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D012372:ROC Curve; D018709:Statistics, Nonparametric; D014463:Ultrasonography; D055815:Young Adult
diabetes; diabetic neuropathy; neuropathy; peripheral nerve; ultrasound