Innate Immune Memory: Activation of Macrophage Killing Ability by Developmental Duties.
Innate immune systems in many taxa exhibit hallmarks of memory in response to previous microbial exposure. A new study demonstrates that innate immune memory in Drosophila embryonic macrophages can also be induced by the successful engulfment of apoptotic cells, highlighting the importance of early exposure events for developing responsive immune systems.
Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA. Electronic address: dschneid@stanford.edu.
David
D
Schneider
Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.
Ann Thomas
AT
Tate
D000818:Animals; D004330:Drosophila; D007113:Immunity, Innate; D007156:Immunologic Memory; D008264:Macrophages / Q000502:physiology*