Interleukin 15: A key cytokine for immunotherapy.
Interleukin (IL)-15, a member of the immunoregulatory cytokines family, is a pluripotent molecule with therapeutic potential. It is predominantly expressed by the myeloid cells, as well as other cell types. IL-15 serves multiple functions including dictating T cell response, regulating tissue repair and B cell homing, modulating inflammation, and activating NK cells. Among cytokines, IL-15 is unique because of its wide expression, tightly regulated secretion, trans-presentation, and therapeutic potential. IL-15 has been investigated for its therapeutic potential for the induction and maintenance of T cell responses. In addition, IL-15 can be targeted by antibody- or mutant IL-15 therapy to reduce inflammation. Its multifaceted biological applications are crucial in immunotherapy. In this article, we review the functions, expression, and regulation of IL-15 for designing an improved IL-15-based therapy targeting the IL-15 signaling pathway.
Institute of Science, Nirma University, Ahmedabad 382481, India. Electronic address: manoj1patidar@gmail.com.
Manoj
M
Patidar
Institute of Science, Nirma University, Ahmedabad 382481, India. Electronic address: Naveen.yadavbt@gmail.com.
Naveen
N
Yadav
Institute of Science, Nirma University, Ahmedabad 382481, India. Electronic address: sarat.dalai@nirmauni.ac.in.
Sarat K
SK
Dalai
D000818:Animals; D015658:HIV Infections / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D019409:Interleukin-15 / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use*; D008288:Malaria / Q000628:therapy; D014376:Tuberculosis / Q000628:therapy
D019409:Interleukin-15
Autoimmune diseases; Interleukin-15; JAK/STAT; mTOR