Catalyst-Free Singlet Oxygen-Promoted Decarboxylative Amidation of α-Keto Acids with Free Amines.
A novel catalyst-free decarboxylative amidation of α-keto acids with amines under mild conditions has been developed. Advantages of the new protocol include avoidance of metal catalysts and high levels of functional group tolerance. In addition, the reaction can be scaled up and shows high chemoselectivity. Preliminary mechanistic studies suggest that singlet oxygen, generated from oxygen under irradiation, is the key promoter for this catalyst-free transformation.
School of Biological and Medical Engineering, Hefei University of Technology, Key Laboratory of Advanced Functional Materials and Devices of Anhui Province , Hefei 230009, P. R. China.
Wen-Tao
WT
Xu
School of Biological and Medical Engineering, Hefei University of Technology, Key Laboratory of Advanced Functional Materials and Devices of Anhui Province , Hefei 230009, P. R. China.
Bei
B
Huang
School of Biological and Medical Engineering, Hefei University of Technology, Key Laboratory of Advanced Functional Materials and Devices of Anhui Province , Hefei 230009, P. R. China.
Jian-Jun
JJ
Dai
School of Biological and Medical Engineering, Hefei University of Technology, Key Laboratory of Advanced Functional Materials and Devices of Anhui Province , Hefei 230009, P. R. China.
Jun
J
Xu
School of Biological and Medical Engineering, Hefei University of Technology, Key Laboratory of Advanced Functional Materials and Devices of Anhui Province , Hefei 230009, P. R. China.
Hua-Jian
HJ
Xu