Comparative lineage tracing reveals cellular preferences for prostate cancer initiation.
The interplay of different cell types of origin and distinct oncogenic mutations may determine the tumor subtype. We have recently found that although both basal and luminal epithelial cells can initiate prostate tumorigenesis, the latter are more likely to undergo transformation in response to a range of oncogenic events.
Department of Molecular Cell & Developmental Biology; University of California , Santa Cruz, CA, USA.
Zhu A
ZA
Wang
Departments of Medicine, Genetics and Development, Urology, and Systems Biology; Columbia Stem Cell Initiative; Herbert Irving Comprehensive Cancer Center; Columbia University College of Physicians and Surgeons , New York, NY, USA.
Michael M
MM
Shen
cell of origin; mouse models; prostate cancer; tumor initiation