Microtubule plus tips: A dynamic route to chromosomal instability.
Although chromosomal instability (CIN) is a recognized hallmark of cancer the underlying mechanisms and consequences are largely unknown. However, it is accepted that lagging chromosomes represent a major prerequisite for chromosome missegregation in cancer cells. Here, we discuss how lagging chromosomes are generated and our recent findings establishing increased microtubule assembly rates as a source of CIN.
Institute of Molecular Oncology; Section for Cellular Oncology; Goettingen Center for Molecular Biosciences (GZMB) and University Medical Center Goettingen (UMG); Georg-August University ; Goettingen, Germany.
Ailine
A
Stolz
Institute of Molecular Oncology; Section for Cellular Oncology; Goettingen Center for Molecular Biosciences (GZMB) and University Medical Center Goettingen (UMG); Georg-August University ; Goettingen, Germany.
Norman
N
Ertych
Institute of Molecular Oncology; Section for Cellular Oncology; Goettingen Center for Molecular Biosciences (GZMB) and University Medical Center Goettingen (UMG); Georg-August University ; Goettingen, Germany.
Holger
H
Bastians
CIN; aneuploidy; merotelic attachments; microtubule dynamics; mitosis