Bioabsorbable radiopaque water-responsive shape memory embolization plug for temporary vascular occlusion.
We describe the preparation, characterization and evaluation of a biodegradable radiopaque water-triggered shape memory embolization plug for temporary vascular occlusion. The shape memory occluding device consists of a composite of a radio-opaque filler and a poly (dl-lactide-co-glycolide) (PLGA) blend, which was coated with a crosslinked poly (ethylene glycol) diacrylate (PEGDA) hydrogel. The mechanical properties, the degradation timeframe, the effect of programming conditions on the shape memory behaviour and the extent of radio-opacity for imaging were evaluated. Based on the tests, the mechanism responsible for the water-induced shape memory effect in such an embolization plug was elucidated. Suitable materials were optimized to fabricate an embolic plug prototype and its in vitro performance was evaluated as an occlusion rate (using a custom-built set up) and its biocompatibility. Finally, a feasibility study was conducted in vivo in a rabbit model to investigate the ease of device deployment, device migration and extent of vessel occlusion. The in vivo results demonstrated that the prototypes were visible under fluoroscopy and complete vascular occlusion occurred within 2 min of deployment of the prototypes in vivo. In conclusion, the developed embolization plug enables controlled and temporary vascular embolization, and is ready for safety studies.
School of Materials Science & Engineering, Nanyang Technological University, Singapore, 639798, Singapore.
Yee Shan
YS
Wong
Nanyang Institute of Technology in Health and Medicine, Nanyang Technological University, Singapore, 639798, Singapore.
Abhijit Vijay
AV
Salvekar
Department of Diagnostic Radiology, Singapore General Hospital, Singapore, 169608, Singapore.
Kun Da
KD
Zhuang
Institute of Materials Research and Engineering, A*STAR, Singapore, 138364, Singapore.
Hui
H
Liu
Institute of Materials Research and Engineering, A*STAR, Singapore, 138364, Singapore.
William R
WR
Birch
Department of Diagnostic Radiology, Singapore General Hospital, Singapore, 169608, Singapore.
Kiang Hiong
KH
Tay
School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, 639798, Singapore.
Wei Min
WM
Huang
School of Materials Science & Engineering, Nanyang Technological University, Singapore, 639798, Singapore. Electronic address: assubbu@ntu.edu.sg.
Subbu S
SS
Venkatraman
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000627:therapeutic use; D004621:Embolization, Therapeutic / Q000379:methods*; D020100:Hydrogels / Q000737:chemistry* / Q000627:therapeutic use; D019344:Lactic Acid / Q000737:chemistry* / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000627:therapeutic use; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000627:therapeutic use; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011817:Rabbits; D014867:Water / Q000737:chemistry
D001672:Biocompatible Materials; D020100:Hydrogels; C437167:poly(ethylene glycol)diacrylate; D014867:Water; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols
Biodegradable; Embolization; PEG hydrogel; Poly(lactide-co- glycolide); Shape-memory