Vitamin D Status and Quality of Life in Healthy Male High-Tech Employees.
While low vitamin D status has been shown to be associated with decreased quality of life in unhealthy populations and women, only limited data are available regarding healthy adult men. Our aim was to evaluate the associations between health-related quality of life (QoL) and vitamin D status in adult men. High-tech employees aged 25-65 year were recruited from an occupational periodic examination clinic at Rambam Health Campus. QoL was assessed using the Centers for Disease Control and Prevention (CDC) Health-related quality of life questionnaire (HRQOL-4). Serum 25-hydroxyvitamin D (25(OH)D) and Body Mass Index (BMI) were measured; further information was collected about physical activity, education, sun exposure, sick-days, and musculoskeletal pain severity (visual analog scale). Three hundred and fifty-eight men were enrolled in the study; mean serum 25(OH)D level was 22.1 ± 7.9 ng/mL (range 4.6-54.5 ng/mL). In a multivariate logistic regression model, 25(OH)D was a significant independent determinant of self-rated health; Odds Ratio (OR) for self-rated health was 0.91 (95% confidence interval (CI) 0.85-0.97, p = 0.004), adjusted for age, BMI, pain severity, physical activity, and sun exposure. Every 1 ng/mL increase of 25(OH)D was associated with 9% reduction in the odds of reporting self-rated health as fair or poor. Poisson regression model demonstrated an association between physically unhealthy days and 25(OH)D levels (rate ratio 0.95, p < 0.001). In conclusion, serum levels of 25(OH)D were associated with self-rated health and with physically unhealthy days of HRQOL in healthy high-tech male workers. Future intervention studies are required to test the impact of vitamin D supplementation on QoL.
The S. Daniel Abraham International Center for Health and Disease, Department of Public Health, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva 8410501, Israel. sigalt@bgu.ac.il.
Sigal
S
Tepper
Department of Clinical Nutrition, Rambam Health Care Campus, Haifa 31093, Israel. yaelidabush@gmail.com.
Yael
Y
Dabush
The S. Daniel Abraham International Center for Health and Disease, Department of Public Health, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva 8410501, Israel. dshahar@bgu.ac.il.
Danit R
DR
Shahar
School of Public Health, Haifa University, Mt. Carmel, Haifa 31905, Israel. ronit.endevelt@moh.gov.il.
Ronit
R
Endevelt
The S. Daniel Abraham International Center for Health and Disease, Department of Public Health, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva 8410501, Israel. diklah.geva@gmail.com.
Diklah
D
Geva
Department of Endocrinology &amp; Diabetes, Elisha Medical Center, Haifa 3463626, Israel. sishshalom@gmail.com.
Sofia
S
Ish-Shalom
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D019587:Dietary Supplements; D015444:Exercise; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011788:Quality of Life; D015203:Reproducibility of Results; D013472:Sunlight; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000008:administration & dosage / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood*
D014807:Vitamin D
25(OH)D; healthy men; quality of life; vitamin D