Dynamic BH3 profiling-poking cancer cells with a stick.
The vast majority of efforts in precision medicine for cancer try to link static genetic information to tumor biology and from there predict clinical response. Dynamic BH3 profiling offers an alternative functional approach by measuring death signaling induced by specific drugs in tumors from patients ex vivo to predict clinical response.
Dana-Farber Cancer Institute, Harvard Medical School , Boston, MA, USA.
Joan
J
Montero
Dana-Farber Cancer Institute, Harvard Medical School , Boston, MA, USA.
Anthony
A
Letai