The cancer cell 'energy grid': TGF-β1 signaling coordinates metabolism for migration.
Cancer cells have an increased reliance on lipogenesis, which is required for uncontrolled cell division. We recently reported transcriptional and functional 'reprogramming' of the cellular energy grid, allowing cancer cells to divert metabolism from biosynthesis to bioenergetic pathways and thus supplying enhanced mobility during epithelial-mesenchymal transition (EMT) induced by transforming growth factor β (TGF-β1) (Fig. 1).
Children's Medical Center Research Institute; University of Texas Southwestern Medical Center ; Dallas, TX USA.
Lei
L
Jiang
Children's Medical Center Research Institute; University of Texas Southwestern Medical Center ; Dallas, TX USA.
Ralph
R
Deberardinis
Departments of Pharmacology and Radiation Oncology; University of Texas Southwestern Medical Center ; Dallas, TX USA.
David A
DA
Boothman
Epithelial-to-Mesenchymal Transition; fatty acid synthase; lipogenesis; metastasis; transforming growth factor beta 1 (TGFβ1)