The link between long noncoding RNAs and depression.
The major depressive disorder (MDD) is a relatively common mental disorder from which that hundreds of million people have suffered, leading to displeasing life quality, which is characterized by health damage and even suicidal thoughts. The complicated development and functioning of MDD is still under exploration. Long noncoding RNA (lncRNAs) are highly expressed in the brain, could affect neural stem cell maintenance, neurogenesis and gliogenesis, brain patterning, synaptic and stress responses, and neural plasticity. The dysregulation of certain lncRNAs induces in neurodevelopmental, neurodegenerative and neuroimmunological disorders, primary brain tumors, and psychiatric diseases. Although advances have been made, no fully satisfactory treatments for major depression are available, further investigation is requested. And recently data showed that the expression level of the majority of lncRNAs demonstrated a clear tendency of upregulation, and the certain dysregulated miRNAs and lncRNAs in the MDD have been proved to have a co-synergism mechanism, that is why we speculate lncRNA might get the capability to regulate MDD. Few identified lncRNAs have been deeply studied in detailed experiments up until now, little predictions of their function have been raised, and further researches is calling for discover their signal pathway and related regulatory networks.
Department of Psychological Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Xiao
X
Huang
Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai 200065, China.
Yan-Li
YL
Luo
Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yue-Shi
YS
Mao
Department of Psychological Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address: jianlin-ji@hotmail.com.
Jian-Lin
JL
Ji
D000818:Animals; D003863:Depression / Q000235:genetics* / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism*
D062085:RNA, Long Noncoding
Biomarker; Long noncoding RNAs (lncRNAs); Major depressive disorder (MDD); Mechanism; Signaling pathway