[Human papillomavirus infection and its correlates with clinically relevant gynecological and obstetric conditions: A cross-sectional study].
OBJECTIVE
To analyze the prevalence of human papillomavirus (HPV) infection and the possible epidemiological association with conditions of clinical relevance in women.


METHODS
A cross-sectional study from Mexico City was conducted from January 2012 to December 2014. HPV molecular detection was performed on cervical samples. Data were analyzed with appropriated statistic tests.


RESULTS
A total of 1,604 females (median 47, interquartile range 38-54) were analyzed. Global prevalence of infection for any HPV is 9.91% (95% CI 8.6-11.3). An association between infection with 16-HPV and number of abortions (NA) (OR=1.427; 95% CI 1.091-1.866), by univariate regression model (UVRM) was estimated. Moreover, menarche (OR=1.566; 95% CI 1.079-2.272), NA (OR=1.570; 95% CI 1.106-2.227) and number of pregnancies (NP) (OR=0.461; 95% CI 0.260-0.818) have a direct and inverse association with infection by genotype 18 of HPV, respectively. Also, infection with HR-HPV genotypes has an inverse association with NP (OR=0.791; 95% CI 0.707-0.884) by normal labor (OR=0.867; 95% CI 0.767-0.979) and NA (OR=0.715; 95% CI 0.534-0.959) (UVRM), and a direct association with number of sexual partners (OR=1.082; 95% CI 1.015-1.154). Onset of sexual activity has an inverse association with infection by genotype 16- (UVRM: OR=0.814; 95% CI 0.715-0.926; multinomial regression model (MNRM): OR=0.803; 95% CI 0.702-0.918) and HR-HPV (UVRM: OR=0.933; 95% CI 0.889-0.980, and MNRM: OR=0.912; 95% CI 0.867-0.959), all P values were lower than .03.


CONCLUSIONS
Prevalence of HPV cervical infection is different according to age and it is associated with several medical conditions of clinical relevance in women.
Centro de Investigación y de Educación Continua (CENINVEC), Ciudad Nezahualcóyotl, Estado de México, México; Clínica de Medicina Familiar Gustavo A. Madero, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Ciudad de México, México. Electronic address: ceninvec@gmail.com.
Daniel
D
López-Hernández
Clínica de Medicina Familiar Gustavo A. Madero, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Ciudad de México, México.
Luis
L
Beltrán-Lagunes
Centro de Investigación y de Educación Continua (CENINVEC), Ciudad Nezahualcóyotl, Estado de México, México.
Leticia
L
Brito-Aranda
Centro de Investigación y de Educación Continua (CENINVEC), Ciudad Nezahualcóyotl, Estado de México, México.
Maria de la Luz
Mde L
López-Hernández
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000821:virology; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
Abortion; Aborto; Cervical cancer; Cáncer cervical; Embarazo; Human papillomavirus infection; Infección; Infección por el virus del papiloma humano; Infection; Pregnancy; Prevalence; Prevalencia