Facile Diastereoseparation of Glycosyl Sulfoxides by Chiral Stationary Phase.
Separation of the diastereomers of glycosyl sulfoxides differing in the sulfur chirality has been difficult. This article presents a fast and scalable method for their diastereoseparation using a chiral stationary phase. The usefulness of this method was demonstrated in a 500-mg scale separation within 20 min, and in the separation of trisaccharyl sulfoxide diastereomers. Chirality 28:534-539, 2016. © 2016 Wiley Periodicals, Inc.
Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Sapporo, Japan.
Tohru
T
Taniguchi
Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Sapporo, Japan.
Mai
M
Asahata
Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Sapporo, Japan.
Akihito
A
Nasu
Faculty of Environmental Earth Science, Hokkaido University, Sapporo, Japan.
Yukatsu
Y
Shichibu
Faculty of Environmental Earth Science, Hokkaido University, Sapporo, Japan.
Katsuaki
K
Konishi
Faculty of Advanced Life Science, Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Sapporo, Japan.
Kenji
K
Monde
Kahne glycosidation; carbohydrate; chiral HPLC; sulfur chirality