Is Transforming Stem Cells to Pancreatic Beta Cells Still the Holy Grail for Type 2 Diabetes?
Diabetes is a progressive disease affecting millions of people worldwide. There are several medications and treatment options to improve the life quality of people with diabetes. One of the strategies for the treatment of diabetes could be the use of human pluripotent stem cells or induced pluripotent stem cells. The recent advances in differentiation of stem cells into insulin-secreting beta-like cells in vitro make the transplantation of the stem cell-derived beta-like cells an attractive approach for treatment of type 1 and type 2 diabetes. While stem cell-derived beta-like cells provide an unlimited cell source for beta cell replacement therapies, these cells can also be used as a platform for drug screening or modeling diseases.
Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, MA, 02215, USA.
Sevim
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Kahraman
Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, MA, 02215, USA.|Division of Endocrinology, Department of Medicine, Boston Children's Hospital, Boston, MA, 02215, USA.
Erin R
ER
Okawa
Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, MA, 02215, USA. Rohit.Kulkarni@joslin.harvard.edu.|Harvard Stem Cell Institute, Boston, MA, 02215, USA. Rohit.Kulkarni@joslin.harvard.edu.
Rohit N
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Kulkarni
D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000628:therapy*; D000072669:Gene Editing; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D050417:Insulin-Secreting Cells / Q000166:cytology*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*
Diabetes; Differentiation; Human pluripotent stem cells; Induced pluripotent stem cells; Pancreatic beta cells