Aggressive Granulosa Cell Tumor of the Ovary with Rapid Recurrence: a Case Report and Review of the Literature.
Aggressive adult granulosa cell tumor (AGCT) of the ovary remains uncommon. We report a case of aggressive AGCT of the ovary who had rapid recurrence at two months after surgery. A patient was referred for further examination of a pelvic tumor. She underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymphadenectomy. In the areas showing a sarcomatoid pattern, the mitotic count were 25/10 HPFs, and the mitoses were most prominent in foci composed of pleomorphic cells with enlarged and bizarre nuclei. In some areas, tumor cells with relatively uniform nuclei proliferated in a trabecular pattern. The mitotic count was 4/10 HPFs. Tumor cells were diffusely positive for α-inhibin. She was diagnosed as having aggressive AGCT. The Ki-67 labeling index in the sarcomatoid AGCT was higher (40%) than that in the areas of typical AGCT (3%). Immunostaining for p53 in the sarcomatoid AGCT was almost strongly positive, but that in typical AGCT was negative. Two months later after the initial surgery, a recurrent abdominal 12 cm-sized mass developed after performing adjuvant chemotherapy consisting of paclitaxel and carboplatin. She died of the disease at 3 months after initial surgery. A markedly higher mitotic count, a higher Ki-67 labeling index, and strong immunoreactivity of p53 in AGCT suggests highly malignant potential. In such a case, a careful follow-up is warranted due to the possibility of rapid recurrence.
Department of Obstetrics and Gynecology, Sanda Municipal Hospital, Sanda, Japan.
Ayako
A
Sonoyama
Department of Obstetrics and Gynecology, Sanda Municipal Hospital, Sanda, Japan.
Masatoshi
M
Kanda
Department of Obstetrics and Gynecology, Sanda Municipal Hospital, Sanda, Japan.
Yojiro
Y
Ojima
Department of Pathology, Sanda Municipal Hospital, Sanda, Japan.
Tomohiko
T
Kizaki
Department of Obstetrics and Gynecology, Sanda Municipal Hospital, Sanda, Japan.
Noriyuki
N
Ohara
D000328:Adult; D000368:Aged; D005260:Female; D006106:Granulosa Cell Tumor / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D013997:Time Factors
Ki-67; aggressive granulosa cell tumor; immunohistochemistry; ovary; rapid recurrence; α-inhibin