USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics.
The critical function of cellular inhibitor of apoptosis proteins (cIAPs) in the protection of cancer cells from numerous apoptotic stimuli prompted the development of second mitochondria-derived activator of caspases (SMAC) mimetics. We recently addressed a novel survival pathway in which cIAP2 is induced by tumor necrosis factor-α and is stabilized by its specific deubiquitylase, USP11, rendering cells resistant to SMAC mimetics.
Department of Biochemistry; College of Life Science and Biotechnology; Yonsei University ; Seoul, Korea.
Eun-Woo
EW
Lee
Department of Biochemistry; College of Life Science and Biotechnology; Yonsei University ; Seoul, Korea.
Jaewhan
J
Song
Deubiquitylation; SMAC mimetics; TRAIL; USP11; cIAP2