Regulation of protein synthesis and autophagy in activated dendritic cells: implications for antigen processing and presentation.
Antigenic peptides presented in the context of major histocompatibility complex (MHC) molecules originate from the degradation of both self and non-self proteins. T cells can therefore recognize at the surface of surveyed cells, the self-peptidome produced by the cell itself (mostly inducing tolerance) or immunogenic peptides derived from exogenous origins. The initiation of adaptive immune responses by dendritic cells (DCs), through the antigenic priming of naïve T cells, is associated to microbial pattern recognition receptors engagement. Activation of DCs by microbial product or inflammatory cytokines initiates multiple processes that maximize DC capacity to present exogenous antigens and stimulate T cells by affecting major metabolic and membrane traffic pathways. These include the modulation of protein synthesis, the regulation of MHC and co-stimulatory molecules transport, as well as the regulation of autophagy, that, all together promote exogenous antigen presentation while limiting the display of self-antigens by MHC molecules.
Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Institut National de la Santé et de la Recherche Médicale U1104, Centre National de la Recherche Scientifique UMR7280, Marseille, France.
Rafael J
RJ
Argüello
Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Institut National de la Santé et de la Recherche Médicale U1104, Centre National de la Recherche Scientifique UMR7280, Marseille, France.
Marisa
M
Reverendo
Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Institut National de la Santé et de la Recherche Médicale U1104, Centre National de la Recherche Scientifique UMR7280, Marseille, France.|Institute for Research in Biomedicine (iBiMED), Aveiro, Health Sciences Program, University of Aveiro, Aveiro, Portugal.
Evelina
E
Gatti
Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Institut National de la Santé et de la Recherche Médicale U1104, Centre National de la Recherche Scientifique UMR7280, Marseille, France.|Institute for Research in Biomedicine (iBiMED), Aveiro, Health Sciences Program, University of Aveiro, Aveiro, Portugal.
Philippe
P
Pierre
D056704:Adaptive Immunity; D000818:Animals; D017951:Antigen Presentation; D001324:Autoantigens / Q000378:metabolism; D001343:Autophagy; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000378:metabolism; D006801:Humans; D056747:Immunomodulation; D010455:Peptides / Q000378:metabolism; D014176:Protein Biosynthesis; D017634:Self Tolerance; D013601:T-Lymphocytes / Q000276:immunology*
D001324:Autoantigens; D006649:Histocompatibility Antigens; D010455:Peptides
DALIS; DRiPs; antigenic peptide; autophagy; peptidome; ribosome