Cytosolic pH: A conserved regulator of cell growth?
Although target of rapamycin (TOR) kinase and Ras are central regulators of cell growth in yeast and mammals, the molecular mechanisms underlying their regulation by nutrients are still poorly understood. Interestingly, recent studies identified cytosolic pH as a critical regulatory signal for both pathways, which might have widespread implications for tumor cell biology.
Institute of Biochemistry; ETH Zurich; Zurich, Switzerland; Competence Center for Systems Physiology and Metabolic Diseases; Zurich, Switzerland.
Reinhard
R
Dechant
Institute of Biochemistry; ETH Zurich; Zurich, Switzerland; Competence Center for Systems Physiology and Metabolic Diseases; Zurich, Switzerland.
Matthias
M
Peter
Ras/PKA; TORC1; cytosolic pH; growth control; nutrient sensing