Relationship between serum arginase I and l-arginine or exhaled nitric oxide in asthma.
The relationship between serum arginase I and serum l-arginine or fractional exhaled nitric oxide (FENO) was evaluated cross-sectionally in asthmatic patients. No sex difference was observed in the serum mean levels of arginase I and l-arginine or FENO. Arginase I and FENO were higher in patients 60 or younger years than in those over 60 years. Asthmatic patients were divided into three groups: no steroid therapy, inhalation steroid therapy, and oral steroid therapy. Arginase I, FENO and high-sensitivity-C-reactive protein (hs-CRP) were significantly lower in the inhalation steroid therapy group than in the no steroid therapy group. Correlations were observed between arginase I and FENO, l-arginine, hs-CRP, WBC, and age, and also between FENO and IgE, WBC, and age. A logistic regression analysis revealed the positive association of arginase I with FENO, and the negative association of l-arginine. FENO was positively associated with arginase I and IgE. These results indicated that serum arginase I might influence serum levels of l-arginine and FENO, and that IgE might influence FENO in asthmatic patients.
a Department of Public Health , Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
Keiki
K
Ogino
b Division of Respiratory Diseases, Department of Medicine , Kawasaki Medical School , Okayama , Japan.|c Second Department of Internal Medicine , Nagasaki University School of Medicine , Nagasaki , Japan.
Yasushi
Y
Obase
d Department of Molecular Pathology , Memorial Sloan-Kettering Cancer Center , New York , NY , USA.
Tatsuo
T
Ito
e Respiratory Medicine, National Hospital Organization Nanao Hospital , Nanao , Japan.
Masaki
M
Fujimura
a Department of Public Health , Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
Eri
E
Eguchi
a Department of Public Health , Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
Masayuki
M
Kubo
a Department of Public Health , Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
Kenjiro
K
Nagaoka
f Department of Environmental and Preventive Medicine , Graduate School of Medical Science, Kanazawa University , Kanazawa , Japan.
Hiroyuki
H
Nakamura
D001119:Arginase / Q000378:metabolism*; D001120:Arginine / Q000378:metabolism*; D001249:Asthma / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*
D009569:Nitric Oxide; D001120:Arginine; D001119:Arginase
Arginase I; clinical study; fractional exhaled nitric oxide (FENO); l-arginine