[Tofacitinib for the treatment of rheumatoid arthritis].
The combined use of synthetic disease-modifying anti-rheumatic drugs (sDMARDs) such as methotrexate and biological DMARDs (bDMARDs) has revolutionized treatment of rheumatoid arthritis (RA). Remission is now realistic targets, achieved by a large proportion of RA patients. However, bDMARDs are limited to intravenous or subcutaneous uses and orally available small but strong products have been developed. Oral administration of tofacitinib targeting the Janus kinase (JAK) is significantly effective than placebo in active RA patients with sDMARD-naïve, inadequately responsive to sDMARDs or TNF-inhibitors. The efficacy was rapid and as strong as adalimumab, a TNF-inhibitor. The common adverse events were related to infection, hematologic and hepatic disorders and association of tofacitinib with carcinogenicity and infections remains debated.
Yoshiya
Y
Tanaka
D060433:Administration, Ophthalmic; D018501:Antirheumatic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D001384:Azetidines; D002986:Clinical Trials as Topic; D055808:Drug Discovery; D006801:Humans; D053612:Janus Kinases / Q000037:antagonists & inhibitors / Q000502:physiology; D008214:Lymphocytes / Q000276:immunology; D058990:Molecular Targeted Therapy; D010880:Piperidines / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D011687:Purines; D011720:Pyrazoles; D011743:Pyrimidines / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D011758:Pyrroles / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D013449:Sulfonamides; D016896:Treatment Outcome
D018501:Antirheumatic Agents; D001384:Azetidines; D010880:Piperidines; D011687:Purines; D011720:Pyrazoles; D011743:Pyrimidines; D011758:Pyrroles; D013449:Sulfonamides; C479163:tofacitinib; D053612:Janus Kinases; C000596027:baricitinib