Caveolin-1 polymorphisms in patients with severe obstructive sleep apnea.
OBJECTIVE
To investigate the associations of G14713A and T29107A polymorphic variants of Caveolin-1 with severe obstructive sleep apnea (OSA).


METHODS
This study was performed on 86 severe OSA patients and 86 controls. Genotyping was performed to investigate the association of G14713A and T29107A polymorphisms of Caveolin-1 with severe OSA.


RESULTS
The distribution of genotypes of T29107A was significantly different between controls and OSA patients with a higher proportion of TT carriers in the OSA group.


CONCLUSIONS
T29107A-specific genotype of Caveolin-1 may be linked with severe OSA pathogenesis.
a Department of Chest Diseases , Yuzuncu Yil University School of Medicine , Van , Turkey.
Selvi
S
Asker
b Department of Medical Biology , Yuzuncu Yil University School of Medicine , Van , Turkey.
Mehmet
M
Taspinar
c Biometry and Genetic Unit, Faculty of Agriculture , Yuzuncu Yil University , Van , Turkey.
Hasan
H
Koyun
d Department of Chest Diseases , Mugla Sitki Kocman University School of Medicine , Mugla , Turkey.
Bulent
B
Ozbay
a Department of Chest Diseases , Yuzuncu Yil University School of Medicine , Van , Turkey.
Ahmet
A
Arisoy
D016022:Case-Control Studies; D051242:Caveolin 1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000235:genetics*
C495540:CAV1 protein, human; D051242:Caveolin 1
G14713A; T29107A; genotype; polymorphic variant