Effects of cetirizine in dogs with chronic atopic dermatitis: a randomized, double blind, placebo-controlled trial.
This study was conducted to evaluate the effects of cetirizine in dogs with atopic dermatitis (AD) while fulfilling Favrot's diagnostic clinical criteria. Dogs received either 3 mg/kg cetirizine (n = 27), or a placebo (n = 23) orally once daily for 14 days in a randomized, double blind, placebo-controlled study, without concomitant medication. The effects were evaluated using a pruritus visual analog scale at the start (day 0) and at day 14. After 14 days, cetirizine clearly had no effect on the pruritus in dogs with chronic AD, and there was no significant difference between groups. These findings indicated that cetirizine (and likely H1 histamine receptor antagonists in general) should not be recommended for the control of pruritus in dogs with long term allergies.
Asian Referral Center, Taipei 106, Taiwan.
Yun-Hsia
YH
Hsiao
Asian Referral Center, Taipei 106, Taiwan.
Charles
C
Chen
Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands.
Ton
T
Willemse
D000818:Animals; D017332:Cetirizine / Q000627:therapeutic use*; D002908:Chronic Disease; D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy* / Q000209:etiology; D004285:Dogs; D004311:Double-Blind Method; D005260:Female; D039563:Histamine H1 Antagonists, Non-Sedating / Q000627:therapeutic use*; D008297:Male; D016896:Treatment Outcome
D039563:Histamine H1 Antagonists, Non-Sedating; D017332:Cetirizine
atopic dermatitis; cetirizine; dogs; placebo-controlled study