High-sensitivity troponin and right ventricular function in acute pulmonary embolism.
BACKGROUND
Right ventricular (RV) dysfunction has proved to be an important predictor of morbidity and mortality in patients with pulmonary embolism (PE). Tricuspid annular plane systolic excursion (TAPSE) is one of the parameters that have been validated as predictor of outcomes. The aim of our study was to evaluate the performance (sensitivity and specificity) of high-sensitivity cardiac troponin T (hs-cTnT) to predict RV dysfunction defined as TAPSE <16 mm.


METHODS
We conducted a single-center retrospective analysis of 40 patients prospectively included. Median age was 66 years (59-76) and PESI score was 81 (67-100).


RESULTS
Right ventricular dysfunction was present in 30% of the patients and was associated with higher median troponin values (33.5 ng/L vs 16 ng/L; P= .03). A logarithmic relation was observed between hs-cTnT and lower TAPSE values (r(2)= 0.36; P< .0001). The area under the ROC curve of hs-cTnT to predict RV dysfunction was 0.77 (0.63-0.92).


CONCLUSIONS
hs-cTnT is a biomarker with good performance to identify RV dysfunction in PE.
Instituto Cardiovascular de Buenos Aires (ICBA), Buenos Aires, Argentina. Electronic address: daquarti@hotmail.com.
Gustavo
G
Daquarti
Instituto Cardiovascular de Buenos Aires (ICBA), Buenos Aires, Argentina.
Nicolás
N
March Vecchio
Instituto Cardiovascular de Buenos Aires (ICBA), Buenos Aires, Argentina.
Cecilia Soledad
CS
Mitrione
Instituto Cardiovascular de Buenos Aires (ICBA), Buenos Aires, Argentina.
Juan
J
Furmento
Instituto Cardiovascular de Buenos Aires (ICBA), Buenos Aires, Argentina.
María Clara
MC
Ametrano
Instituto Cardiovascular de Buenos Aires (ICBA), Buenos Aires, Argentina.
María Paz
MP
Dominguez Pace
Instituto Cardiovascular de Buenos Aires (ICBA), Buenos Aires, Argentina.
Juan Pablo
JP
Costabel
D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014336:Troponin / Q000097:blood*; D016278:Ventricular Function, Right / Q000502:physiology*
D015415:Biomarkers; D014336:Troponin