Autophagy is critically required for DNA repair by homologous recombination.
Autophagy delivers damaged cytoplasmic constituents to lysosomes for degradation, thus preserving cellular integrity and protecting against disease. Remarkably, autophagy-deficient cells also exhibit aberrant DNA damage responses with therapeutic implications, such as suppression of checkpoint kinase-1 function, impaired DNA double-strand break repair by homologous recombination, and increased reliance on error-prone non-homologous end-joining for survival.
Centre for Biomedical Research of the Canary Islands; Department of Anatomy; Anatomical Pathology and Physiology, Faculty of Medicine, Universidad de La Laguna ; Tenerife, Spain.
David A
DA
Gillespie
Cancer Research UK Beatson Institute ; Garscube Estate, Switchback Rd , Glasgow, UK.
Kevin M
KM
Ryan
Chk1; DNA repair; autophagy; homologous recombination