Roles of ghrelin in left-ventricular remodelling after acute myocardial infarction.
OBJECTIVE
The purpose of this study was to elucidate the role of ghrelin after acute myocardial infarction (AMI) in left ventricular (LV) remodelling.


METHODS
Prospective observational study.


METHODS
Jichi Medical University Hospital.


METHODS
Fifty consecutive patients experiencing their first AMI.


METHODS
Ghrelin was measured on the day of admission, day 7, day 14 and 6 months after AMI. Patients were treated by percutaneous coronary intervention, and successful myocardial reperfusion was accomplished within 12 h after onset. To analyse LV remodelling, the authors performed left ventriculographies on the day of admission and 6 months after AMI.


METHODS
Changes in LV volume.


RESULTS
Plasma ghrelin increased significantly after AMI (admission: 40.9±7.3; day 7: 89.5±11.0; day 14: 92.6±11.8 fmol/ml, p<0.0001). There was a significant correlation between ghrelin on day 14 and changes in LV volume over 6 months (r=+0.46, p<0.001). Multivariate regression analysis showed that ghrelin on day 14 is a significant predictor of LV remodelling after AMI (β=+0.44, p=0.001).


CONCLUSIONS
To our knowledge, this is the first report that shows a relation between circulating ghrelin after AMI and the progression of LV remodelling in the chronic phase. The elevation of ghrelin after AMI might be a compensatory mechanism to attenuate LV remodelling.
Department of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Hideyuki
H
Kondo
Department of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Yukihiro
Y
Hojo
Department of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Nozomu
N
Takahashi
Department of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Tomokazu
T
Ikemoto
Department of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Hirotaka
H
Aoki
Division of Integrative Physiology, Department of Physiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Katsuya
K
Dezaki
Department of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Kazuomi
K
Kario
Department of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Takaaki
T
Katsuki
Division of Integrative Physiology, Department of Physiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Toshihiko
T
Yada
Department of Cardiology, Jichi Medical University, Shimotsuke-city, Tochigi, Japan.
Kazuyuki
K
Shimada
AMI; Acute coronary syndrome; Acute coronary syndromes; BMI; C-reactive protein; CPK-AUC; CRP; GH; Ghrelin; IGF-1; LV; LVEDVI; LVEF; Metabolism; Myocardial ischaemia; PCI; Ventricular remodelling; acute myocardial infarction; body mass index; creatine phosphokinase-area under the curve; growth hormone; insulin-like growth factor-1; left ventricular; left ventricular ejection fraction; left ventricular end-diastolic volume index; percutaneous coronary intervention