Iron-Catalyzed Hydroboration: Unlocking Reactivity through Ligand Modulation.
Iron-catalyzed hydroboration (HB) of alkenes and alkynes is reported. A simple change in ligand structure leads to an extensive change in catalyst activity. Reactions proceed efficiently over a wide range of challenging substrates including activated, unactivated and sterically encumbered motifs. Conditions are mild and do not require the use of reducing agents or other additives. Large excesses of borating reagent are not required, allowing control of chemo- and regioselectivity in the presence of multiple double bonds. Mechanistic insight reveals that the reaction is likely to proceed via a highly reactive iron hydride intermediate.
Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Maialen
M
Espinal-Viguri
Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Callum R
CR
Woof
Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK. r.l.webster@bath.ac.uk.
Ruth L
http://orcid.org/0000-0001-9199-7579
RL
Webster
alkenes; alkynes; homogeneous catalysis; hydroboration; iron