Speed matters: How subtle changes in DNA end resection rate affect repair.
The contribution of BRCA1 (breast cancer 1) to the repair of broken DNA is well established, but its real role at the molecular level is less well understood. By developing a new high-resolution, single-molecule technique, we have now shown that BRCA1 accelerates the processing of DNA breaks that subsequently engage in homologous recombination.
Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER); Sevilla, Spain; Departamento de Genética; Universidad de Sevilla; Sevilla, Spain.
Pablo
P
Huertas
Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER); Sevilla, Spain; Departamento de Genética; Universidad de Sevilla; Sevilla, Spain.
Andrés
A
Cruz-García
BRCA1; CtIP; DNA end resection; DNA repair/recombination