The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family.
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. RET/PTC rearrangement is the most common genetic modification identified in this category of cancer, increasing proliferation and dedifferentiation by the activation of the RET/PTC-RAS-BRAF-MAPK-ERK signaling pathway. Recently, let-7 miRNA was found to reduce RAS levels, acting as a tumor suppressor gene. Circulating miRNA profiles of the let-7 family may be used as novel noninvasive diagnostic, prognostic, treatment and surveillance markers for PTC.
Department of Experimental Physiology, Chair of Experimental and Clinical Physiology, Medical University of Lodz, Lodz 92-215, Poland. ewelina.perdas@stud.umed.lodz.pl.
Ewelina
E
Perdas
Department of Clinical Physiology, Medical University of Lodz, Lodz 92-215, Poland. robert.stawski@umed.lodz.pl.
Robert
R
Stawski
Department of Clinical Physiology, Medical University of Lodz, Lodz 92-215, Poland. dariusz.nowak@umed.lodz.pl.
Dariusz
D
Nowak
Department of Experimental Physiology, Chair of Experimental and Clinical Physiology, Medical University of Lodz, Lodz 92-215, Poland. maria.pawelska-zubrzycka@umed.lodz.pl.
Maria
M
Zubrzycka
D002277:Carcinoma / Q000235:genetics*; D002291:Carcinoma, Papillary; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D005810:Multigene Family; D009154:Mutation; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000235:genetics*; D014158:Transcription, Genetic; D059467:Transcriptome
D035683:MicroRNAs; C487931:mirnlet7 microRNA, human
carcinogenesis; let-7 family; miRNAs; papillary thyroid cancer