TRIM32 is a novel negative regulator of p53.
To ensure proper function, the tumor suppressor p53 is tightly regulated through different post-translational modifications, particularly ubiquitination. Recently, TRIM32 was identified as a p53-regulated gene and an E3 ubiquitin ligase of p53. Thus, TRIM32 and p53 form a novel auto-regulatory negative feedback loop for p53 regulation in cells.
Department of Radiation Oncology; Rutgers Cancer Institute of New Jersey; Rutgers, State University of New Jersey ; New Brunswick, NJ USA.
Juan
J
Liu
Department of Radiation Oncology; Rutgers Cancer Institute of New Jersey; Rutgers, State University of New Jersey; New Brunswick, NJ USA; Department of Neurosurgery; First Affiliated Hospital; Zhejiang University School of Medicine; Hangzhou, China.
Yu
Y
Zhu
Department of Radiation Oncology; Rutgers Cancer Institute of New Jersey; Rutgers, State University of New Jersey ; New Brunswick, NJ USA.
Wenwei
W
Hu
Department of Radiation Oncology; Rutgers Cancer Institute of New Jersey; Rutgers, State University of New Jersey ; New Brunswick, NJ USA.
Zhaohui
Z
Feng
TRIM32; negative feedback loop; p53; tumor suppressor