Inner retinal thinning after Brilliant Blue G-assisted internal limiting membrane peeling for vitreoretinal interface disorders.
The aim of this study was to evaluate ganglion cell layer and nerve fiber layer thickness after Brilliant Blue G (BBG)-assisted internal limiting membrane (ILM) peeling for vitreomacular disorders. Retrospective analysis of spectral domain optical coherence tomography (SD-OCT) of 42 eyes of 42 patients, who underwent pars plana vitrectomy with BBG-assisted ILM peeling, was performed. Inclusion criteria were idiopathic macular hole, idiopathic vitreomacular traction, and idiopathic epiretinal membrane. Key exclusion criteria were vitreoretinal interface abnormalities secondary to any other diseases, follow-up period of less than 3 months, and any other associated retinal pathology. Average, minimum, and sectoral ganglion cell, and inner plexiform layers (GCIPL) and retinal nerve fiber layer (RNFL) parameters were collected. Changes in these parameters from baseline to 3- and 6-month visits after surgery were analyzed. At 3 months after surgery, we found a statistically significant reduction in the average GCIPL thickness (P = 0.031) and also in the superior sectors (P < 0.05) compared to the baseline values. A similar reduction was observed in the minimum RNFL thickness (P = 0.028) as well as in the superior sectoral RNFL thickness (P < 0.05). In 14 eyes with 6 months of follow-up, a similar statistically significant thinning of the GCIPL and RNFL was observed. However, the difference between the 3-month and 6-month values was not statistically significant (P = 0.679). BBG-assisted ILM peeling for vitreomacular interface disorders leads to thinning of the inner retina including GCIPL and RNFL. These structural changes should be correlated with retinal function tests to explore the pros and cons of this surgical step.
Smt. Kannuri Santhamma Centre for Vitreoretinal Diseases, LV Prasad Eye Institute, Kallam Anji Reddy Campus Banjara Hills Road no. 2, Hyderabad, Andhra Pradesh, 500 034, India.
Vikas
V
Ambiya
Smt. Kannuri Santhamma Centre for Vitreoretinal Diseases, LV Prasad Eye Institute, Kallam Anji Reddy Campus Banjara Hills Road no. 2, Hyderabad, Andhra Pradesh, 500 034, India.
Abhilash
A
Goud
Smt. Kannuri Santhamma Centre for Vitreoretinal Diseases, LV Prasad Eye Institute, Kallam Anji Reddy Campus Banjara Hills Road no. 2, Hyderabad, Andhra Pradesh, 500 034, India.
Mitali
M
Khodani
Smt. Kannuri Santhamma Centre for Vitreoretinal Diseases, LV Prasad Eye Institute, Kallam Anji Reddy Campus Banjara Hills Road no. 2, Hyderabad, Andhra Pradesh, 500 034, India. jay.chhablani@gmail.com.
Jay
J
Chhablani
D000368:Aged; D019773:Epiretinal Membrane / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007202:Indicators and Reagents / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D011184:Postoperative Period; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D012394:Rosaniline Dyes / Q000494:pharmacology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D057586:Vitreoretinal Surgery / Q000379:methods*; D014822:Vitreous Body / Q000473:pathology* / Q000601:surgery
D007202:Indicators and Reagents; D012394:Rosaniline Dyes; C004692:coomassie Brilliant Blue
Brilliant Blue G; GCIPL; Ganglion cells; Indocyanine green; Internal limiting membrane peeling; RNFL