[Pathophysiology of hearing loss : Classification and treatment options].
From the therapeutic perspective, the etiology and pathophysiology of hearing loss can be classified based on the extent of the primary cause. Hearing loss can have very different consequences for cell preservation in the organ of Corti and the spiral ganglion. These not only have implications for prosthetic therapy outcome, but may also influence the potential for future causal molecular therapies. Etiologies leading to deficits that are limited to one or a few molecules without having an effect on cell survival have the greatest potential for future causal therapy using molecular and cellular approaches. Preliminary success for molecular therapy was recently reported in animal experiments. Unfortunately, the incidence of these types of hearing loss is very low and in the future the therapy of hearing loss will therefore also require several different approaches. In addition to peripheral pathophysiology, hearing loss has consequences on the functioning of the brain, which can vary greatly due to individual adaptation to the situation without hearing. The authors therefore argue for individualization of the diagnostics and therapy that focus not only the symptom of hearing loss, but also the individual pathophysiology and consequences. Only with individualized therapy can the success of treating hearing disorders be significantly improved.
Institut für AudioNeuroTechnologie & Abteilung für Experimentelle Otologie der HNO-Klinik, Medizinische Hochschule Hannover, Stadtfelddamm 34, 30625, Hannover, Deutschland. kral.andrej@mh-hannover.de.
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D000818:Animals; D019317:Evidence-Based Medicine; D015316:Genetic Therapy / Q000379:methods*; D034381:Hearing Loss / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D057285:Precision Medicine / Q000379:methods*; D033581:Stem Cell Transplantation / Q000379:methods*; D016896:Treatment Outcome
Cochlear implants; Deafness; Development; Sensorineural hearing loss; Treatment outcome