Association between Ala379Val polymorphism of lipoprotein-associated phospholipase A2 and migraine without aura in Iranian population.
BACKGROUND
Migraine is a common neurovascular disorder with multifactorial and polygenic inheritance. The aim of this study was to investigate the association of a migraine without aura and Ala379Val polymorphism of lipoprotein-associated phospholipase A2 (Lp-PLA2) gene in the Iranian population.


METHODS
In this study, 103 migraine patients and 100 healthy controls were enrolled. DNA samples were extracted and the Ala379Val polymorphism of Lp-PLA2 gene was investigated. To assess severity of a headache, patients filled out the headache impact test (HIT-6) and migraine severity (MIGSEV) questionnaires.


RESULTS
Allele V had significantly lower frequency in the case group than control subjects [P = 0.001, odds ratio (OR) = 0.25, confidence interval (CI): 0.15-0.40]. The frequency of migraine patients that were a carrier of V allele (V/V and A/V) was statistically significant lower than the control group (P = 0.003, OR = 2.39, CI: 1.35-4.23). There was no significant difference of alleles frequency between three grades of MIGSEV (P = 0.316). Furthermore, total HIT-6 score was not significantly different between different genotypes (P = 0.466).


CONCLUSIONS
Our results showed that Ala379Val gene polymorphism of LP-PLA2 is associated with lower risk of migraine but not with severity of headaches in an Iranian population.
Medical Student Research Center AND Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Faraidoon
F
Haghdoost
Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mahsa
M
Gharzi
Pharmacy Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Farough
F
Faez
Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Elinaz
E
Hosseinzadeh
Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohamadhasan
M
Tajaddini
Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Laleh
L
Ra Ei
Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Fatemeh
F
Asgari
Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mahboobeh
M
Banihashemi
Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Samaneh Sadat
SS
Masjedi
Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Alireza
A
Zandifar
Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Shaghayegh
S
Haghjooy-Javanmard
Gene Polymorphism; Headache; Lp-PLA2; Migraine; Questionnaires‎