Association Between Serum Triglycerides and Cerebral Amyloidosis in Cognitively Normal Elderly.
Although many preclinical studies have suggested the possible linkage between dyslipidemia and cerebral amyloid deposition, the association between serum lipid measures and cerebral amyloid-beta (Aβ) deposition in human brain is still poorly known. We aimed to investigate the association in cognitively normal (CN) elderly individuals.



Cross-sectional study.



University hospital dementia clinic.



59 CN elderly.



The study measures included comprehensive clinical and neuropsychological assessment based on the CERAD protocol, magnetic resonance imaging and (11)C-labelled Pittsburgh Compound B positron emission tomography scans, and quantification for serum lipid biomarkers.



Multiple linear regression analyses showed that a higher serum triglycerides level was associated with heavier global cerebral Aβ deposition even after controlling age, sex, and apolipoprotein E ε4 genotype. Serum apolipoprotein B also showed significant positive association with global cerebral Aβ deposition, but the significance disappeared after controlling serum triglycerides level. No association was found between other lipid measures and global cerebral Aβ deposition.



The findings suggest that serum triglycerides are closely associated with cerebral amyloidosis, although population-based prospective studies are needed to provide further evidence of the causative effect of triglycerides on cerebral amyloidosis.
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Hyo Jung
HJ
Choi
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Min Soo
MS
Byun
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Dahyun
D
Yi
Department of Neuropsychiatry, Ulsan University Hospital, Ulsan, Republic of Korea.
Young Min
YM
Choe
Department of Neuropsychiatry, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
Bo Kyung
BK
Sohn
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Hye Won
HW
Baek
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Jun Ho
JH
Lee
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Hyun Jung
HJ
Kim
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Ji Young
JY
Han
Department of Nuclear Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
Eun Jin
EJ
Yoon
Department of Nuclear Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
Yu Kyeong
YK
Kim
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Jong Inn
JI
Woo
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address: selfpsy@snu.ac.kr.
Dong Young
DY
Lee
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000686:Amyloidosis / Q000097:blood / Q000000981:diagnostic imaging*; D053327:Apolipoprotein E4 / Q000235:genetics; D001055:Apolipoproteins B / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D003071:Cognition; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D056910:Republic of Korea; D014280:Triglycerides / Q000097:blood*
D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4; D001055:Apolipoproteins B; D015415:Biomarkers; D014280:Triglycerides
Alzheimer disease; PET; brain amyloid; lipid; triglycerides