PTHrP, its receptor, and protein kinase A activation in osteosarcoma.
In osteosarcoma, knockdown of the parathyroid hormone-related protein (PTHrP) receptor reduces activation through cyclic AMP-dependent protein kinase A (PKA) and substantially decreases tumor differentiation, invasion, and proliferation in vivo. These findings complement other evidence supporting a central role of the PKA pathway in osteosarcoma biology and pathogenesis.
St. Vincent's Institute of Medical Research and Department of Medicine; St. Vincent's Hospital; University of Melbourne ; Fitzroy, VIC, Australia.
Carl R
CR
Walkley
St. Vincent's Institute of Medical Research and Department of Medicine; St. Vincent's Hospital; University of Melbourne ; Fitzroy, VIC, Australia.
Mannu K
MK
Walia
St. Vincent's Institute of Medical Research and Department of Medicine; St. Vincent's Hospital; University of Melbourne ; Fitzroy, VIC, Australia.
Patricia W
PW
Ho
St. Vincent's Institute of Medical Research and Department of Medicine; St. Vincent's Hospital; University of Melbourne ; Fitzroy, VIC, Australia.
T John
TJ
Martin
PKA; PTHR1; PTHrP; osteosarcoma