Usefulness of IGF-1 serum levels as diagnostic marker of nasopharyngeal carcinoma.
The role of IGF-1 in promoting cancer has been investigated for many years. The aim of this study is to explore the relationship between rates of IGF-1 and NPC and to evaluate association of IGF-1 with clinical parameters.



IGF-1 levels was measured by Elisa test among 82 NPC patients and 60 healthy controls



Our results showed, for the first time, a significant increased levels of IGF-I in NPC by in comparison with healthy controls (p<0.01). According to the age, sex and tumor size of NPC patients, we demonstrated that IGF-1 concentrations are significantly higher in NPC aged over 30 years compared to patients aged less than 30 years (p<0.01). The IGF-1 levels are, also, higher among women compared to men (p<0.01). The concentrations of IGF-1 were positively correlated with tumor size of NPC patients (p<0.01).



IGF-I could be a good nasopharyngeal cancer diagnostic marker.
Laboratory of Immuno-Histo-Cytology, Institute of Carcinology; Salah Azaiz, Tunis, Tunisia. Electronic address: hayet.mamdi@yahoo.com.
H
H
M'hamdi
Laboratory of Immuno-Histo-Cytology, Institute of Carcinology; Salah Azaiz, Tunis, Tunisia. Electronic address: nehla.mokni@rns.tn.
N Mokni
NM
Baizig
Laboratory of Immuno-Histo-Cytology, Institute of Carcinology; Salah Azaiz, Tunis, Tunisia. Electronic address: olfaelamine@yahoo.fr.
O ElAmine
OE
ELHadj
Department of Animal Sciences National Institute of Agronomy of Tunis, Tunisia. Electronic address: naceur_mhamdi@yahoo.fr.
N
N
M'hamdi
Department of ORL. Institute of Carcinology Salah Azaiz of Tunis, Tunisia. Electronic address: attia.zied@yahoo.fr.
Z
Z
Attia
Department of ORL. Institute of Carcinology Salah Azaiz of Tunis, Tunisia. Electronic address: said.gritli@rns.tn.
S
S
Gritli
Laboratory of Immuno-Histo-Cytology, Institute of Carcinology; Salah Azaiz, Tunis, Tunisia. Electronic address: amor.gamoudi@rns.tn.
A
A
Gamoudi
Research Unit 01/UR/08-07.Faculty of Medicine, Tunis, University of Tunis El Manar,Tunisia. Electronic address: elmay_michele@yahoo.fr.
M Veronique
MV
El May
Laboratory of Immuno-Histo-Cytology, Institute of Carcinology; Salah Azaiz, Tunis, Tunisia. Electronic address: ahmed_elmay2@yahoo.fr.
A El May
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D002277:Carcinoma / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D016896:Treatment Outcome; D047368:Tumor Burden; D055815:Young Adult
D014408:Biomarkers, Tumor; D007334:Insulin-Like Growth Factor I
Diagnostic marker; IGF-1 circulating; Nasopharyngeal carcinoma; Tunisia