Transcriptome profiling links the intrinsic properties of human prostate basal cells to prostate cancer aggressiveness.
Genome-wide transcriptome analysis of human benign prostatic basal and luminal epithelial populations reveals the unexpected findings that basal cells preferentially express gene categories associated with stem cells, neurogenesis, and rRNA biogenesis. Importantly, the basal cell gene expression profile is enriched in clinically advanced, anaplastic, castration-resistant, and metastatic prostate cancers.
Department of Epigenetics and Molecular Carcinogenesis, the University of Texas MD Anderson Cancer Center, Smithville, TX, USA; Department of Pharmacology & Therapeutics, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY.
Dingxiao
D
Zhang
Basal stem cells; human prostate epithelial cells; neurogenesis; prostate cancer; transcriptome