Biomimetic composite scaffolds containing bioceramics and collagen/gelatin for bone tissue engineering - A mini review.
Bone is a natural composite material consisting of an organic phase (collagen) and a mineral phase (calcium phosphate, especially hydroxyapatite). The strength of bone is attributed to the apatite, while the collagen fibrils are responsible for the toughness and visco-elasticity. The challenge in bone tissue engineering is to develop such biomimetic composite scaffolds, having a balance between biological and biomechanical properties. This review summarizes the current state of the field by outlining composite scaffolds made of gelatin/collagen in combination with bioactive ceramics for bone tissue engineering application.
Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences & Research Center, Amrita Vishwa Vidyapeetham University, Kochi, 682041 Kerala, India.
Shruthy
S
Kuttappan
Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences & Research Center, Amrita Vishwa Vidyapeetham University, Kochi, 682041 Kerala, India.
Dennis
D
Mathew
Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences & Research Center, Amrita Vishwa Vidyapeetham University, Kochi, 682041 Kerala, India. Electronic address: manithanair@aims.amrita.edu.
Manitha B
MB
Nair
D000818:Animals; D032701:Biomimetics; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry*; D001842:Bone and Bones / Q000503:physiopathology; D003094:Collagen / Q000737:chemistry; D006801:Humans; D006882:Hydroxyapatites / Q000737:chemistry; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
D018786:Bone Substitutes; D006882:Hydroxyapatites; D003094:Collagen
Biomimetic scaffolds; Bone tissue engineering; Collagen; Composite scaffolds; Gelatin