Two new phenols from Lysimachia patungensis.
Two new phenols, methyl 3-(2-O-β-d-glucopyranosyl-3-hydroxy-5-methoxyphenyl) propionate (1) and myricetin-3,3',5'-tri-O-α-l-rhamnopyranoside (2), together with six known phenols compounds (3-8), were isolated from the whole plant of Lysimachia patungensis Hand.-Mazz. Their structures were elucidated on the basis of the interpretation of spectroscopic data, viz., ESI-MS, HR-TOF-MS, UV, IR, and NMR. All the known phenols were isolated from the genus Lysimachia for the first time. A preliminary bioassay revealed that compounds 3 and 7 exhibited significant protective effects against hydrogen peroxide-induced damage in human retinal endothelial cells (HRECs) with the concentration of 10 μM, respectively. Compound 1 showed moderate activity against the HRECs damage at 100 μM.
a School of Pharmacy , Shanghai University of Traditional Chinese Medicine , Shanghai 201203 , China.
Yuan-Yuan
YY
Gao
a School of Pharmacy , Shanghai University of Traditional Chinese Medicine , Shanghai 201203 , China.
Peng
P
Zeng
b Yueyang Hospital and Clinical Research Institute of Integrative Medicine , Shanghai University of Traditional Chinese Medicine , Shanghai 200437 , China.
Cheng-Lin
CL
Jia
c Drug Discovery and Design Centre & CAS Key Laboratory of Receptor Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
Yong
Y
Zhang
b Yueyang Hospital and Clinical Research Institute of Integrative Medicine , Shanghai University of Traditional Chinese Medicine , Shanghai 200437 , China.
Teng
T
Zhang
a School of Pharmacy , Shanghai University of Traditional Chinese Medicine , Shanghai 201203 , China.
Qi
Q
Jia
a School of Pharmacy , Shanghai University of Traditional Chinese Medicine , Shanghai 201203 , China.
Yi-Ming
YM
Li
D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D042783:Endothelial Cells / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification*; D029623:Primulaceae / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D005960:Glucosides; D006027:Glycosides; D010636:Phenols; C000614000:methyl 3-(2-O-beta-D-glucopyranosyl-3-hydroxy-5-methoxyphenyl)propionate; C000614001:myricetin-3,3',5'-tri-O-alpha-L-rhamnopyranoside; C040015:myricetin
Lysimachia patungensis; Primulaceae; antioxidant activity; methyl 3-(2-O-β-d-glucopyranosyl-3-hydroxy-5-methoxyphenyl) propionate; myricetin-3,3′,5′-tri-O-α-l-rhamnopyranoside; phenols