Association between RNF41 gene c.-206 T > A genetic polymorphism and risk of congenital heart diseases in the Chinese Mongolian population.
This study aimed to explore the association between ring finger protein 41 (RNF41) c.-206 T > A variant and susceptibility to congenital heart disease (CHD) in the Chinese Mongolian population. The association between RNF41 gene c.-206 T > A polymorphism and CHD was examined in two independent case-control studies consisting of 219 CHD patients and 208 healthy controls. Genotype was determined by direct sequencing of PCR products. We found that the genotype frequencies of RNF41 c.-206 T > A differ significantly between the two groups (P < 0.05). The TT and TA genotypes in the CHD group were 80.67 and 19.33%, respectively. On the other hand, the frequencies of TT and TA in the control group were 94.44 and 5.56%, respectively. Furthermore, the allelic frequencies of CHD patients (T, 90.34%; A, 9.66%) were significantly different as compared with those of non-CHD controls (T, 97.22%; A, 2.78%; χ2 = 4.031, P = 0.041). Our study demonstrates that the RNF41 c.-206 T > A polymorphism may be a risk factor for congenital heart disease in the Chinese Mongolian population.
Department of Pathophysiology, Baotou Medical College, Baotou, China.|The Central Laboratory, Shenzhen Second People's Hospital, Shenzhen University First Affiliated Hospital, Shenzhen, China.
Y
Y
Zhang
Department of Cardiology, The First Affiliated Hospital of Baotou Medical College, Baotou, China.
S Q
SQ
Jin
Department of Pediatric Cardiology, Beijing Anzhen Hospital Affiliated the Capital Medical University, Beijing, China.
W X
WX
Li
Department of Emergency, The Central Hospital of Wulanchabu City, Wulanchabu, China.
G Q
GQ
Gao
Department of Pathophysiology, Baotou Medical College, Baotou, China.
K
K
Zhang
The Central Laboratory, Shenzhen Second People's Hospital, Shenzhen University First Affiliated Hospital, Shenzhen, China.
J L
JL
Huang
D044466:Asian People / Q000235:genetics; D002675:Child, Preschool; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006330:Heart Defects, Congenital / Q000235:genetics*; D006801:Humans; D008297:Male; D008986:Mongolia / Q000208:ethnology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
C452580:RNF41 protein, human; D044767:Ubiquitin-Protein Ligases