Antitrypanosomal Activity of a Novel Taccalonolide from the Tubers of Tacca leontopetaloides.
BACKGROUND
Several taccalonolides with various bioactivities have been isolated from Tacca species but no studies to isolate taccalonolides with anti-trypanosomal activity from Tacca leontopetaloides have been reported.


OBJECTIVE
To analyse extracts of the roots of Tacca leontopetaloides, purify the extracts by column chromatography and identify isolated compounds by spectroscopic methods. The compounds and fractions will be tested for antitrypanosomal activity in vitro against Trypanosoma brucei brucei.


METHODS
Dried roots or tubers of Tacca leontopetaloides, chromatographic separation and spectroscopic identification.


RESULTS
A novel taccalonolide A propanoate and some known taccalonolides were isolated and their structures were determined by NMR and mass spectrometry


CONCLUSIONS
Several taccalonolides were isolated from Tacca leontopetaloides and were found to have in vitro antitrypanosomal activity against Trypanosoma brucei brucei and EC50 values for the isolated compounds were from 0.79 µg/mL. Copyright © 2016 John Wiley & Sons, Ltd.
Phytochemistry Research Group, Department of Chemistry, University of Agriculture PMB 2373, Makurdi, Benue State, Nigeria.
Vivian T
VT
Dike
Phytochemistry Research Group, Department of Chemistry, University of Agriculture PMB 2373, Makurdi, Benue State, Nigeria.
Burbwa
B
Vihiior
Department of Veterinary Physiology, Pharmacology and Biochemistry, University of Agriculture, PMB 2373, Makurdi, Benue State, Nigeria.
Joel A
JA
Bosha
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow, G4 0NR, UK.
Tung Mei
TM
Yin
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Godwin Unekwuojo
GU
Ebiloma
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Harry P
HP
de Koning
Phytochemistry Research Group, Department of Chemistry, University of Agriculture PMB 2373, Makurdi, Benue State, Nigeria.
John O
JO
Igoli
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow, G4 0NR, UK.
Alexander I
AI
Gray
D027743:Dioscoreaceae / Q000737:chemistry*; D013058:Mass Spectrometry; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D035281:Plant Tubers / Q000737:chemistry; D011422:Propionates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects*
D010936:Plant Extracts; D011422:Propionates; D013256:Steroids; D014344:Trypanocidal Agents; C475870:taccalonolide A
Tacca leontopetaloides; Taccalonolides; antitrypanosomal activity; taccalonolide A 12-propanoate