Significance of ETV6 rearrangement in acute promyelocytic leukemia with t(15;17)/promyelocytic leukemia/retinoic acid receptor alpha.
Acute promyelocytic leukemia (APL) is a common subtype of acute myeloid leukemia in China. Since the application of arsenic trioxide and all-trans retinoic acid in the treatment of APL, the prognosis has greatly improved. However, ~20% of patients with APL relapse upon completing chemotherapy. Decreasing the relapse rate and incidence of early mortality may pose the greatest challenges for the future management of APL. Recently, Ets variant 6 (ETV6) was reported to be involved in a variety of translocations associated with hematological malignancies of myeloid and lymphoid origin. To date, little is known about the clinical implication of ETV6 rearrangement in APL. In the present study, ETV6 rearrangement was examined by split-signal fluorescencein situhybridization in 258 adults with APL, and its association with the clinical features and outcomes of the patients was analyzed. The data suggested that ETV6 rearrangement may be an independent unfavorable prognostic factor for overall survival in APL patients.
Department of Hematology, Central Hospital of Jinan, Shandong University School of Medicine, Jinan, Shandong 250013, P.R. China; Department of Hematology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.
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NA
Gao
Department of Hematology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.
Wen-Zheng
WZ
Yu
Department of Hematology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.
Xue-Xia
XX
Wang
Department of Hematology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.
Jian-Rong
JR
Sun
Department of Pathology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.
Ning
N
Yu
Department of Hematology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.
Zeng-Yan
ZY
Liu
Department of Hematology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.
Xiao-Dan
XD
Liu
Department of Hematology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.
Ren-Tong
RT
Liu
Department of Hematology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China.
Rui
R
Feng
Department of Hematology, Central Hospital of Jinan, Shandong University School of Medicine, Jinan, Shandong 250013, P.R. China.
Bu-Tong
BT
Ding
Department of Hematology, Central Hospital of Jinan, Shandong University School of Medicine, Jinan, Shandong 250013, P.R. China.
Tan
T
Sang
Department of Hematology, Central Hospital of Jinan, Shandong University School of Medicine, Jinan, Shandong 250013, P.R. China.
Nong-Jian
NJ
Guo
Ets variant 6 gene; acute promyelocytic leukemia; prognosis; rearrangement; split-signal FISH