Cutaneous Collision Tumor Associated With Porocarcinomatous and Angiosarcomatous Components: A Potential Diagnostic Pitfall.
Sarcomatoid eccrine porocarcinoma (SEP) is a very rare malignancy including epithelial and mesenchymal components exhibiting pleomorphic cells, nuclear hyperchromasia, and high mitotic activity in both elements. To date, only 6 cases of this uncommon neoplasm have been reported, corresponding to women over 70 years of age with ulcerated skin lesions. The authors describe the first sarcomatoid eccrine porocarcinoma in a 75-year-old male patient with a right hallux lesion, presenting a collision tumor with a mixed population of epithelial cells and a spindle cell angiosarcomatous mesenchymal component each expressing distinct and nonoverlapping morphologic and immunohistochemical features of epithelial and mesenchymal differentiation.
*Department of Pathology, National Institute of Cancer, Bogotá, Colombia; †Department of Pathology, Fundación Universitaria de Ciencias de la Salud, Bogotá, Colombia; and ‡Department of Pathology, Universidad de La Sabana, Chia, Colombia.
Rafael
R
Parra-Medina
Mario A
MA
Melo-Uribe
Oscar
O
Messa-Botero
Samuel D
SD
Morales
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D057090:Eccrine Porocarcinoma / Q000473:pathology*; D006394:Hemangiosarcoma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009260:Nail Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor