Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer.
To identify clinically relevant downstream effectors of androgen signaling, the androgen-regulated kinome was defined in prostate cancer (PCa). Within this study, choline kinase α (CHKA) was identified as an androgen receptor chaperone that is both a biomarker of progression and a potential therapeutic target for PCa.
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK; Department of Oncology, Addenbrooke's Hospital, CB2 2QQ Cambridge, UK.
Mohammad
M
Asim
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK; Department of Oncology, Addenbrooke's Hospital, CB2 2QQ Cambridge, UK.
Charlie E
CE
Massie
Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK; Department of Oncology, Addenbrooke's Hospital, CB2 2QQ Cambridge, UK.
David E
DE
Neal
Androgen Receptor; chaperones; prostate cancer; therapeutic target