[MECHANISMS OF GASTRODUODENAL DYSMOTILITY UNDER STRESS].
Psychogenic stress in rabbits caused dysmotility of the gastroduodenal zone: inhibition of contractile activity (CA) in antral and pyloric parts of the stomach simultaneously with the increase of CA in proximal and distal parts of duodenum. Stress induced inhibition of the gastric contractile activity is substantially "non-adrenergic non-cholinergic" and only in the initial phase of the reaction it appears to be "α-adrenergic". The strengthening of CA in the proximal duodenum resulted from the direct exciting action of endocrine stress factor on the smooth muscle of the gut. The strengthening of the CA in the distal duodenum is a result of the endocrine action of catecholamines on stimulating β-adrenergic receptors of enteric cho linergic neurons. Stress induced dyscoordination of the gastroduodenal motility can cause duodenogastric reflux and as a consequence, erosive damage of the gastric mucosa.
V I
VI
Ovsiannikov
T P
TP
Berezina
K A
KA
Shemerovskii
D000818:Animals; D004195:Disease Models, Animal; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D004569:Electroencephalography; D005753:Gastric Mucosa / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000502:physiology*; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D016065:Myoelectric Complex, Migrating / Q000502:physiology; D018733:Nicotinic Antagonists / Q000494:pharmacology; D011817:Rabbits; D011976:Receptors, Muscarinic / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000378:metabolism; D012149:Restraint, Physical; D013270:Stomach / Q000187:drug effects / Q000503:physiopathology*; D013315:Stress, Psychological / Q000378:metabolism / Q000503:physiopathology*
D018727:Muscarinic Antagonists; D018733:Nicotinic Antagonists; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic