YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations.
Uveal melanoma (UM) is the most common adult intraocular tumor. UM often involves activating mutations in guanine nucleotide binding protein (G protein), q polypeptide (GQ), or G Protein, α 11 (G11). We show that the Yes-associated protein (Yap) inhibitor verteporfin blocks tumor growth of Gq/11-mutated UM cells.
Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine; University of California; San Diego ; La Jolla, CA USA.
Vera
V
Lyubasyuk
Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine; University of California; San Diego ; La Jolla, CA USA.
Hong
H
Ouyang
Department of Pharmacology and Moores Cancer Center; University of California; San Diego ; La Jolla, CA USA.
Fa-Xing
FX
Yu
Department of Pharmacology and Moores Cancer Center; University of California; San Diego ; La Jolla, CA USA.
Kun-Liang
KL
Guan
Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine; University of California; San Diego ; La Jolla, CA USA.
Kang
K
Zhang
Yes-associated protein (YAP); guanine nucleotide binding protein (G protein); mutation; uveal melanoma; verteporfin