Oxidative stress signaling to chromatin in health and disease.
Oxidative stress has a significant impact on the development and progression of common human pathologies, including cancer, diabetes, hypertension and neurodegenerative diseases. Increasing evidence suggests that oxidative stress globally influences chromatin structure, DNA methylation, enzymatic and non-enzymatic post-translational modifications of histones and DNA-binding proteins. The effects of oxidative stress on these chromatin alterations mediate a number of cellular changes, including modulation of gene expression, cell death, cell survival and mutagenesis, which are disease-driving mechanisms in human pathologies. Targeting oxidative stress-dependent pathways is thus a promising strategy for the prevention and treatment of these diseases. We summarize recent research developments connecting oxidative stress and chromatin regulation.
King Abdullah University of Science & Technology (KAUST), Environmental Epigenetics Program, Thuwal 23955-6900, Saudi Arabia.
Sarah
S
Kreuz
King Abdullah University of Science & Technology (KAUST), Environmental Epigenetics Program, Thuwal 23955-6900, Saudi Arabia.
Wolfgang
W
Fischle
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006657:Histones / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D018384:Oxidative Stress; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction
D002843:Chromatin; D006657:Histones
DNA methylation; RNS; ROS; cancer; diabetes; histone acetylation; histone methylation; oxidative stress