A butterfly effect in cancer.
A point mutation in PIK3CA, the gene encoding the α isoform of class I phosphatidylinositol 3-kinase, induces extensive remodeling of the transcriptome and proteome, resulting in a gene signature that specifically resembles that of the basal subtype, but not other types, of breast cancer.
The Scripps Research Institute; Departments of Molecular and Experimental Medicine ; La Jolla, CA USA.
Peter K
PK
Vogt
The Scripps Research Institute; Departments of Molecular and Experimental Medicine ; La Jolla, CA USA.
Jonathan R
JR
Hart
The Scripps Research Institute, Chemical Physiology ; La Jolla, CA USA.
John R
JR
Yates
breast cancer; gene signature; phosphatidylinositol 3-kinase; proteome; transcriptome