Ribosome heterogeneity in tumorigenesis: the rRNA point of view.
The "specialized ribosome" concept proposes that ribosome variants are produced and differentially regulate translation. Examples supporting this notion demonstrated heterogeneity of ribosomal protein composition. However, ribosome translational activity is carried out by rRNA. We, and others, recently showed that rRNA heterogeneity regulates translation to generate distinct translatomes promoting tumorigenesis.
Centre de Recherche en Cancérologie de Lyon; UMR INSERM 1052 CNRS 5286; Centre Léon Bérard; Lyon, France; Université de Lyon; Université Lyon 1; ISPB; Lyon, France.
Virginie
V
Marcel
Centre de Recherche en Cancérologie de Lyon; UMR INSERM 1052 CNRS 5286; Centre Léon Bérard; Lyon, France; Université de Lyon; Université Lyon 1; ISPB; Lyon, France.
Frédéric
F
Catez
Centre de Recherche en Cancérologie de Lyon; UMR INSERM 1052 CNRS 5286; Centre Léon Bérard; Lyon, France; Université de Lyon; Université Lyon 1; ISPB; Lyon, France.
Jean-Jacques
JJ
Diaz
RNA epigenetics; fibrillarin; p53; specialized ribosome; translation; tumorigenesis