Sesquiterpenoid Lactones in Tanacetum huronense Inhibit Human Glioblastoma Cell Proliferation.
Tanacetum huronense (Lake Huron tansy), which is native to the upper Midwest region of USA and Canada, was examined for the presence of anticancer compounds using an in vitro human tumor cell proliferation inhibition assay, with glioblastoma derived cell line U-87 MG. Bioassay-directed purification of the ethyl acetate extract of the aerial portion of this plant identified six active sesquiterpenoid lactones (1-6). Among these, compounds 5 and 6 are new structural analogs. One of the most abundant isolates, tanacin (4), exhibited the greatest inhibition with an IC50 value of 4.5 μg/mL.
Amila A
AA
Dissanayake
Bruce E
BE
Bejcek
Chuan-Rui
CR
Zhang
Muraleedharan G
MG
Nair
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000302:isolation & purification* / Q000627:therapeutic use; D005909:Glioblastoma / Q000188:drug therapy*; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification; D031203:Tanacetum / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; C015524:tanacin