The stress of coping with E2F loss.
E2F transcription factors are key regulators of cellular proliferation, and altered E2F activity is a common feature of tumor cells. Thus, E2F targeting is being explored as a therapeutic strategy in cancer. Importantly, recent mouse knockout studies show that concomitant loss of E2f1/E2f2 activity is associated with increased genomic instability and oncogenic potential in normal differentiating cells, a finding that might have implications for cancer therapy.
Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU , Bilbao, Spain.
Ainhoa
A
Iglesias-Ara
Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU , Bilbao, Spain.
Ana M
AM
Zubiaga
Apoptosis; DNA damage response; E2; p53; replication stress; senescence