Surgical and Oncologic Outcomes After Major Liver Surgery and Extended Hemihepatectomy for Colorectal Liver Metastases.
To determine the surgical and oncologic outcomes after major liver surgery for colorectal liver metastases (CRLM) at a Dutch University Hospital.



Consecutive patients with CRLM who had undergone major liver resection, defined as ≥ 4 liver segments, between January 2000 and December 2015 were identified from a prospectively maintained database.



Major liver surgery was performed in 117 patients. Of these, 26 patients had undergone formal extended left or right hemihepatectomy. Ninety-day postoperative mortality was 8%. Major postoperative complications occurred in 27% of patients; these adverse events were more common in the extended hemihepatectomy group. Median disease-free survival was 11 months and median overall survival 44 months.



Major liver surgery, including formal extended hemihepatectomy, is associated with significant operative morbidity and mortality but can confer prolonged overall survival for patients with CRLM.
Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Inge
I
Ubink
Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Jennifer M J
JMJ
Jongen
Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Maarten W
MW
Nijkamp
Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Eelco F J
EFJ
Meijer
Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Thomas T
TT
Vellinga
Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Richard
R
van Hillegersberg
Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
I Quintus
IQ
Molenaar
Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Inne H M
IHM
Borel Rinkes
Cancer Center, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: j.hagendoorn-3@umcutrecht.nl.
Jeroen
J
Hagendoorn
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000379:methods* / Q000401:mortality; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D016896:Treatment Outcome
Colorectal cancer; Hepatectomy; Metastasis; Morbidity; Survival