Use of Read-Across Tools.
Read-across has become popular since the introduction of regulations, such as the European REACH regulation. This chapter provides instructions on how to use ToxRead, new freely available software for read-across analysis, and on how to interpret its output predictions for mutagenicity assessments.This tool offers two seminal sources: a set of rules/structural alerts, which may explain the toxicity, and a similarity tool, associated with a large database of chemicals with their properties.
Laboratory of Environmental Chemistry and Toxicology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa, 19, 20156, Milan, Italy. serena.manganelli@marionegri.it.
Serena
S
Manganelli
Mario Negri Institute for Pharmacological Research, IRCCS, Milan, Italy.
Emilio
E
Benfenati
D003198:Computer Simulation; D016208:Databases, Factual; D006801:Humans; D015394:Molecular Structure; D009153:Mutagens / Q000737:chemistry*; D021281:Quantitative Structure-Activity Relationship; D012984:Software
D009153:Mutagens
Mutagenicity; REACH; Read-across; Rules; SAR; Structural alerts; ToxRead