A retrospective study of R-CHOP/CHOP therapy-induced nausea and vomiting in non-Hodgkin's lymphoma patients: a comparison of intravenous and oral 5-HT3 receptor antagonists.
Chemotherapy-induced nausea and vomiting (CINV) is a serious problem for cancer patients receiving chemotherapy. The CHOP regimen is the standard treatment for non-Hodgkin's lymphoma (NHL) and is categorized as highly or moderately emetogenic in the CINV guidelines. The efficacy of oral 5-HT3 receptor antagonists is equivalent to that of the intravenous form in patients with solid tumors, but there is no clear comparative data for the use of these agents NHL patients receiving CHOP. We analyzed retrospective CINV data from medical records of 72 NHL patients who received CHOP or rituximab-combined CHOP therapy (R-CHOP). All patients received 5-HT3 receptor antagonists alone for prevention of CINV; 39 of the patients received an intravenous form (mostly granisetron) and 33 an oral form (all ramosetron). Complete response (CR: defined as no vomiting and no rescue therapy) was observed in 58 of 72 patients (80.6 %) overall (0-120 h post-CHOP). The CR rate was not statistically different in patients treated with oral or intravenous 5-HT3 receptor antagonists (82.1 vs 78.8 %, P = 0.77). These findings suggest that oral 5-HT3 receptor antagonists represent a good alternative to intravenous forms in NHL receiving CHOP/R-CHOP chemotherapy. Further studies are needed to identify the optimal anti-emetic supportive therapy for NHL.
Department of Oncology/Hematology, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan. ben2106t@med.shimane-u.ac.jp.
Tsutomu
T
Takahashi
Department of Oncology/Hematology, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Satoshi
S
Kumanomidou
Department of Oncology/Hematology, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Saki
S
Takami
Department of Oncology/Hematology, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Takahiro
T
Okada
Department of Oncology/Hematology, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Koji
K
Adachi
Department of Oncology/Hematology, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Yumi
Y
Jo
Department of Oncology/Hematology, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Fumiyoshi
F
Ikejiri
Department of Oncology/Hematology, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Chie
C
Onishi
Department of Oncology/Hematology, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Koshi
K
Kawakami
Department of Oncology/Hematology, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Takaaki
T
Miyake
Department of Oncology/Hematology, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Masaya
M
Inoue
Department of Oncology/Hematology, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Ichiro
I
Moriyama
Department of Oncology/Hematology, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Ritsuro
R
Suzuki
Department of Oncology/Hematology, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.
Junji
J
Suzumiya
D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D000932:Antiemetics / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D009325:Nausea / Q000139:chemically induced* / Q000517:prevention & control; D011241:Prednisone / Q000627:therapeutic use; D012189:Retrospective Studies; D000069283:Rituximab / Q000627:therapeutic use; D058831:Serotonin 5-HT3 Receptor Antagonists / Q000008:administration & dosage*; D014750:Vincristine / Q000627:therapeutic use; D014839:Vomiting / Q000139:chemically induced* / Q000517:prevention & control
D058846:Antibodies, Monoclonal, Murine-Derived; D000932:Antiemetics; C571759:R-CHOP protocol; D058831:Serotonin 5-HT3 Receptor Antagonists; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
CHOP (R-CHOP); Chemotherapy-induced nausea and vomiting; Non-Hodgkin’s lymphoma; Oral 5-HT3 receptor antagonists