Association between QTc of patients with schizophrenia and five genetic polymorphisms of GSTZ1 and XRCC1.
BACKGROUND
Several antipsychotic agents are known to prolong the QT interval. A study was undertaken to find the possible influence of polymorphisms of GSTZ1 (MIM: 603758) and XRCC1 (MIM: 194360) on the rate-corrected QT interval (QTc) in patients with schizophrenia.


METHODS
The study was carried out on 48 inpatients with schizophrenia. The patients were diagnosed with chronic schizophrenia according to structured clinical interviews using SCID-I (clinician version) to confirm and document DSM-IV diagnosis. Measurements of the QT and RR intervals were recorded using a magnifying grid on lead II. The QTc was calculated according to Bazett's formula. A PCR-based method was used to determine the GSTZ1 and XRCC1 genotypes.


RESULTS
Statistical analysis showed that there was no association between the study polymorphisms of GSTZ1 and XRCC1 and QTc.


CONCLUSIONS
GSTZ1 is not associated with QTc in patients treated with antipsychotic drugs.
Mostafa
M
Saadat
Genetics