Analysis of the correlation between lipotoxicity and pituitary-thyroid axis hormone levels in men and male rats.
Lipotoxicity seriously harms human health, but it is unclear whether lipotoxicity is detrimental to the pituitary. We investigated the correlation between serum triglyceride and pituitary axis hormone levels in epidemiological and animal studies. In the epidemiological study, serum thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels were greater in male patients with isolated hypertriglyceridemia than in controls, whereas adrenocorticotropin (ACTH) levels were lower in the patients with hypertriglyceridemia. Pituitary hormone levels correlated with triglyceride levels, even after adjustment for potential confounders. In the animal study, male rats were fed a high-fat or control diet for 28 weeks. As the duration of high-fat feeding increased, the serum and pituitary triglyceride concentrations increased. At early times, the high-fat diet elevated serum TSH and triiodothyronine. At later times, much higher serum TSH levels coupled with reduced thyroxine were observed in the high-fat group. Serum levels of pituitary-gonadal and pituitary-adrenal axis hormones were not affected by the diet. The mRNA and protein expression of Tshβ were greater in the high-fat group than in the control group, whereas expression of Fshβ, Lhβ and Acth had no difference between the groups. Overall, serum triglyceride levels were associated with pituitary-thyroid axis hormone levels.
Department of Endocrinology, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan, Shandong, China.|Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.|Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China.
Jianmei
J
Yang
Department of Endocrinology, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan, Shandong, China.|Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.|Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China.
Xiaoming
X
Zhou
Department of Endocrinology, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan, Shandong, China.|Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.|Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China.
Xu
X
Zhang
Shandong Academy of Pharmaceutical Sciences, Jinan, Shandong, China.
Jianting
J
Hu
Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.|Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China.|Scientific Center, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan, Shandong, China.
Ling
L
Gao
Department of Endocrinology, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan, Shandong, China.|Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.|Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China.
Yongfeng
Y
Song
Department of Endocrinology, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan, Shandong, China.|Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.|Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China.
Chunxiao
C
Yu
Department of Endocrinology, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan, Shandong, China.|Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.|Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China.
Shanshan
S
Shao
Department of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, Shandong, China.
Zhongshang
Z
Yuan
Department of Pediatric Endocrinology, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan, Shandong, China.
Yan
Y
Sun
Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.|Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China.
Huili
H
Yan
Department of Pediatric Endocrinology, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan, Shandong, China.
Guimei
G
Li
Department of Endocrinology, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan, Shandong, China.|Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan, Shandong, China.|Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong, China.
Jiajun
J
Zhao
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D000886:Anthropometry; D049628:Body Size; D001835:Body Weight; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D059305:Diet, High-Fat / Q000009:adverse effects; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000453:epidemiology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010902:Pituitary Gland / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012044:Regression Analysis; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood; D014280:Triglycerides / Q000097:blood*
D012333:RNA, Messenger; D014280:Triglycerides; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin
Pathology Section; anterior pituitary hormones; high-fat lard diet; hypertriglyceridemia; lipotoxicity; pituitary-thyroid axis