The effectiveness of interventions to treat obesity in survivors of childhood brain tumors: a systematic review protocol.
Pediatric brain tumors are the most common solid tumors in children. Advances in understanding the hallmarks of cancer biology and novel therapies have led to an increasing number of survivors of childhood brain tumors (SCBT). However, these survivors are at an increased risk of obesity and cardiometabolic disorders that affect their quality of life and lifespan. It is important to define effective strategies to treat and prevent obesity in this population. This systematic review aims to investigate the effectiveness of lifestyle interventions, pharmacotherapy, and bariatric surgery on treating obesity in SCBT.



Searches will be conducted in PubMed, MEDLINE, EMBASE, PsycINFO, SPORTDiscus, CINAHL, Cochrane Database of Systematic Review, Cochrane Central Register of Controlled Trials (CENTRAL), and Database of Abstracts of Reviews of Effect (DARE). In addition, ClinicalTrials.gov and ProQuest Dissertations and Theses A&I will be searched to identify relevant gray literature. The reference lists of eligible articles will be searched for additional studies. All screening, quality assessment, and data abstraction will be done independently by two reviewers. We will perform meta-analysis if there are sufficient studies.



This review will summarize evidence for the effectiveness of interventions used to reduce obesity risk in SCBT. This has significant implications for SCBT, as it can identify gaps in knowledge and provide insights into the development of new interventions to manage obesity in survivors, which may improve their outcomes.



PROSPERO CRD42015025909.
Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada.|Division of Pediatric Endocrinology, McMaster Children's Hospital, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada.
Kuan-Wen
KW
Wang
Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada.|Division of Pediatric Endocrinology, McMaster Children's Hospital, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada.
Marlie
M
Valencia
Health Sciences Library, McMaster University, Hamilton, Ontario, Canada.
Laura
L
Banfield
Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada.|Division of Pediatric Endocrinology, McMaster Children's Hospital, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada.
Ruth
R
Chau
Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada.|Division of Pediatric Hematology/Oncology, McMaster Children's Hospital, Hamilton, Ontario, Canada.
Adam
A
Fleming
Division of Neurosurgery, Department of Surgery, McMaster Children's Hospital, Hamilton, Ontario, Canada.|McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada.
Sheila K
SK
Singh
Division of Orthopedic Surgery, Department of Surgery, McMaster University Medical Centre, Hamilton, Ontario, Canada.
Sarah
S
Burrow
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Russell J
RJ
de Souza
Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada.|Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.|Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.|Centre for Evaluation of Medicines, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.|Biostatistics Unit, St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
Lehana
L
Thabane
Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada. samaanc@mcmaster.ca.|Division of Pediatric Endocrinology, McMaster Children's Hospital, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada. samaanc@mcmaster.ca.|Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada. samaanc@mcmaster.ca.
M Constantine
MC
Samaan
D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D050110:Bariatric Surgery; D001932:Brain Neoplasms / Q000150:complications* / Q000628:therapy*; D002648:Child; D002985:Clinical Protocols; D006801:Humans; D063868:Patient Outcome Assessment; D063766:Pediatric Obesity / Q000150:complications* / Q000523:psychology / Q000628:therapy*; D011788:Quality of Life; D040242:Risk Reduction Behavior; D017741:Survivors / Q000523:psychology; D000078202:Systematic Reviews as Topic
D019440:Anti-Obesity Agents
Brain tumor; Brain tumor survivors; Cancer survivorship; Children; Intervention; Obesity; Protocol; Systematic review