Enantioselective Oxidation of Diols by Secondary Alcohol Dehydrogenase from Geotrichum sp. WF9101.
Geotrichum sp. WF9101 could degrade (S)-( + )-l,2-propanediol, (S)-( + )-l,3-butanediol, and (2S,4S)-( # )-2,4-pentanediol, but not the corresponding enantiomers. An NAD(+)-linked secondary alcohol dehydrogenase purified from the strain showed the same enantio-selective oxidations towards these diols. This enzyme is proposed to be useful for the preparation of (R)-( - )-diols from the racemates of these diols.
a Osaka Agricultural and Forestry Research Center, Syakudo 442 , Hahikino-shi , Osaka 583 , Japan.
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Tatsuma
a Osaka Agricultural and Forestry Research Center, Syakudo 442 , Hahikino-shi , Osaka 583 , Japan.
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Michio
a Osaka Agricultural and Forestry Research Center, Syakudo 442 , Hahikino-shi , Osaka 583 , Japan.
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Takashi
a Osaka Agricultural and Forestry Research Center, Syakudo 442 , Hahikino-shi , Osaka 583 , Japan.|b Department of Applied Biological Chemistry, College of Agriculture , University of Osaka Prefecture, 1-1 Gakuen-cho , Sakai-shi , Osaka 593 , Japan.
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Takuo
Geotrichum sp.; NAD+-linked secondary alcohol dehydrogenase; enantioselective oxidation of 1,3-butanediol