Trichosporon: another yeast-like organism responsible for immune reconstitution inflammatory syndrome in patients with hematological malignancy.
Trichosporon has recently emerged as a life-threatening opportunistic fungal pathogen, notably in patients with hematological malignancy. Fungemia, sometimes associated with cutaneous lesions and/or pneumonitis, is the major clinical form. Here, we report two cases of patients suffering from acute leukaemia who developed hepatic and/or splenic lesions apart from Trichosporon positive blood cultures. The appearance of hepatic and splenic lesions following the recovery from neutropenia is highly suggestive of a chronic disseminated infection, now considered as an immune reconstitution inflammatory syndrome. Treatment with corticosteroid therapy led to clinical improvement in both cases. Copyright © 2016 John Wiley & Sons, Ltd.
Service d'Hémato-Oncologie Pédiatrique, AP-HP, Hôpital A. Trousseau, Paris, France.|Service de Réanimation Pédiatrique, AP-HP, Hôpital A. Trousseau, Paris, France.
Fanny
F
Alby-Laurent
Service d'Hémato-Oncologie Pédiatrique, AP-HP, Hôpital A. Trousseau, Paris, France.
Catherine
C
Dollfus
Service de Réanimation Médicale, AP-HP, Hôpital St Antoine, Paris, France.
Hafid
H
Ait-Oufella
Service de Réanimation Pédiatrique, AP-HP, Hôpital A. Trousseau, Paris, France.
Jerome
J
Rambaud
Service d'hématologie clinique et de thérapie cellulaire, AP-HP, Hôpital St Antoine, Paris, France.
Ollivier
O
Legrand
Service d'Hémato-Oncologie Pédiatrique, AP-HP, Hôpital A. Trousseau, Paris, France.
Marie-Dominique
MD
Tabone
Assistance Publique-Hôpitaux de Paris, Hôpital St Antoine, Service de Parasitologie-Mycologie, Paris, France.|Inserm, U1135, CIMI-Paris, Paris, France.|CNRS, ERL 8255, CIMI-Paris, Paris, France.|Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France.
Christophe
C
Hennequin
D000368:Aged; D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000209:etiology*; D008297:Male; D014250:Trichosporon / Q000254:growth & development*
IRIS; Trichosporon; chronic disseminated infection; neutropenia