Genomic instability establishes dependencies on acquired gene regulatory networks: A novel role of p62 in myeloid malignancies with del(5q).
MiR-146a deletion is a driving molecular event in del(5q) myeloid malignancies, which acquire dependency on a nuclear factor kappa B (NF-κB) regulatory network. p62, a neighboring haploid 5q gene, is induced by NF-κB and required to sustain TRAF6-mediated NF-κB activation. Interfering with p62/TRAF6 binding may have a therapeutic benefit in miR-146a-deficient leukemic cells.
Division of Experimental Hematology and Cancer Biology; Cincinnati Children's Hospital Medical Center ; Cincinnati, OH, USA.
Jing
J
Fang
Division of Experimental Hematology and Cancer Biology; Cincinnati Children's Hospital Medical Center; Cincinnati, OH, USA; Department of Cancer Biology; University of Cincinnati College of Medicine; Cincinnati, OH, USA.
Daniel T
DT
Starczynowski
5q; AML; MDS; NF-κB; TRAF6; miR-146a; p62