Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade.
Recently, we revealed that ubiquitination of MEKK2 and MEKK3 by inhibitor of apoptosis proteins (IAPs) directly disrupts MEK5/ERK5 interaction and subsequently attenuates ERK5 activation. In addition, loss of XIAP promotes human myogenic differentiation in an ERK5-dependent manner. These results reveal another layer of MAPK regulation and a novel role for XIAP in controlling myogenic differentiation.
Cell Death Signaling Group; Institute of Biochemistry II; Goethe University Medical School ; Frankfurt, Germany.
Katharina
K
Schulenburg
Department of Biochemistry; Eötvös Loránd University; Budapest; Hungary Institute of Enzymology; Research Center for Natural Sciences Hungarian Academy of Sciences ; Budapest, Hungary.
Gabor
G
Glatz
Department of Biochemistry; Eötvös Loránd University; Budapest; Hungary Institute of Enzymology; Research Center for Natural Sciences Hungarian Academy of Sciences ; Budapest, Hungary.
Attila
A
Remenyi
Cell Death Signaling Group; Institute of Biochemistry II; Goethe University Medical School; Frankfurt, Germany; FZI; Molecular Signaling Unit; Institute for immunology; University Medical Center of the Johannes Gutenberg-University Mainz; Mainz, Germany.
Krishnaraj
K
Rajalingam
ERK5; IAP; MAPK; PB1; XIAP; cIAP1; ubiquitin