Enantioselective N-heterocyclic carbene-catalyzed synthesis of saccharine-derived dihydropyridinones with cis-selectivity.
The enantioselective N-heterocyclic carbene-catalyzed [2 + 4] cyclocondensation of α-chloroaldehydes and saccharine-derived 1-azadienes was developed, giving the corresponding saccharine-derived dihydropyridinones in good yields with exclusive cis-selectivities and excellent enantioselectivities.
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. songye@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Zhi-Qin
ZQ
Liang
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. songye@iccas.ac.cn.
Dong-Ling
DL
Wang
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. songye@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Chun-Lin
CL
Zhang
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. songye@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Song
S
Ye
D002384:Catalysis; D003500:Cyclization; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D012439:Saccharin / Q000737:chemistry*; D013237:Stereoisomerism
D004095:Dihydropyridines; C030011:carbene; C038806:1,4-dihydropyridine; D012439:Saccharin; D008697:Methane