Gold Nanoparticles Decorated with Sialic Acid Terminated Bi-antennary N-Glycans for the Detection of Influenza Virus at Nanomolar Concentrations.
Invited for this month's cover picture is the group of Professor Antony Fairbanks and his collaborators at the University of Canterbury and University of Otago. The cover shows the isolation of complex bi-antennary oligosaccharides from hens' eggs and their conjugation to gold nanoparticles. Gold nanoparticles carrying these sugars can then bind to specific receptors (hemagglutinin) on the surface of the influenza virus, causing particle aggregation, which changes their spectroscopic properties. Upon aggregation, they undergo a red-shift in their surface plasmon resonance, as illustrated by the bound particles shining in the cover image. These changes in spectroscopic properties are the basis of a detection system capable of detecting viral hemagglutinin at nanomolar concentrations, as well as the virus itself. For more details, see the Full Paper on p. 708 ff.Read the full text of the article at 10.1002/open.201500109.
Department of Chemistry University of Canterbury Private Bag 4800 Christchurch 8140 New Zealand; The MacDiarmid Institute for Advanced Materials and Nanotechnology Wellington 6140 New Zealand.
Vivek
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Poonthiyil
Department of Microbiology and Immunology University of Otago PO Box 56 Dunedin 9054 New Zealand.
Prashanth T
PT
Nagesh
Department of Microbiology and Immunology University of Otago PO Box 56 Dunedin 9054 New Zealand.
Matloob
M
Husain
Department of Chemistry University of Canterbury Private Bag 4800 Christchurch 8140 New Zealand; The MacDiarmid Institute for Advanced Materials and Nanotechnology Wellington 6140 New Zealand.
Vladimir B
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Golovko
Department of Chemistry University of Canterbury Private Bag 4800 Christchurch 8140 New Zealand; Biomolecular Interaction Centre University of Canterbury Private Bag 4800 Christchurch 8140 New Zealand.
Antony J
0000-0002-9975-3269
AJ
Fairbanks