Body mass index, inflammatory biomarkers and neurocognitive impairment in HIV-infected persons.
To determine the relationships among body mass index (BMI), and HIV-associated neurocognitive impairment and the potential mediating effects of inflammatory cytokines. Among the HIV-infected individuals (N = 90) included in this study, obesity was associated with slower processing speed (β = -.229, standard error (SE) = 2.15, p = .033), compared to participants with a normal BMI, after controlling for psychosocial and HIV clinical factors. Serum concentrations of the interleukin-16 (IL-16) cytokine were significantly associated with slowed processing speed (β = -.235, SE = 1.62, p = .033) but did not mediate the relationship between obesity and processing speed These findings suggest that obesity may contribute to cognitive processing speed deficits in HIV-infected adults. Elevated concentrations of IL-16 are also associated with slowing, though the results suggest that obesity and IL-16 may exert independent effects.
a Department of Epidemiology, College of Public Health and Health Professions, College of Medicine , University of Florida , Gainesville , FL , USA.
Chukwuemeka N
CN
Okafor
a Department of Epidemiology, College of Public Health and Health Professions, College of Medicine , University of Florida , Gainesville , FL , USA.
Natalie E
NE
Kelso
b Department of Clinical and Health Psychology, College of Public Health and Health Professions , University of Florida , Gainesville , FL , USA.
Vaughn
V
Bryant
b Department of Clinical and Health Psychology, College of Public Health and Health Professions , University of Florida , Gainesville , FL , USA.
Larry E
LE
Burrell
c School of Integrated Science and Humanity (SISH) , Florida International University , Miami , FL , USA.
Maria Jose
MJ
Míguez
d Department of Psychiatry , University of California San Diego , San Diego , CA , USA.
Assawin
A
Gongvatana
e Departments of Medicine and Pathology , Warren Alpert Medical School of Brown University , Providence , RI , USA.
Karen T
KT
Tashima
e Departments of Medicine and Pathology , Warren Alpert Medical School of Brown University , Providence , RI , USA.
Suzanne
S
de la Monte
a Department of Epidemiology, College of Public Health and Health Professions, College of Medicine , University of Florida , Gainesville , FL , USA.
Robert L
RL
Cook
f Center for Cognitive Aging and Memory, Institute on Aging, and the Departments of Neurology, Psychiatry, and Aging and Geriatric Research , University of Florida , Gainesville , FL , USA.
Ronald A
RA
Cohen
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D003072:Cognition Disorders; D016207:Cytokines; D005260:Female; D015658:HIV Infections / Q000523:psychology*; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000523:psychology
D015415:Biomarkers; D016207:Cytokines; D007378:Interleukins
HIV; body mass index; cytokines; inflammation; neurocognition