Zika Virus Disease in Colombia - Preliminary Report.
Colombia began official surveillance for Zika virus disease (ZVD) in August 2015. In October 2015, an outbreak of ZVD was declared after laboratory-confirmed disease was identified in nine patients.



Using the national population-based surveillance system, we assessed patients with clinical symptoms of ZVD from August 9, 2015, to April 2, 2016. Laboratory test results and pregnancy outcomes were evaluated for a subgroup of pregnant women. Concurrently, we investigated reports of microcephaly for evidence of congenital ZVD.



By April 2, 2016, there were 65,726 cases of ZVD reported in Colombia, of which 2485 (4%) were confirmed by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay. The overall reported incidence of ZVD among female patients was twice that in male patients. A total of 11,944 pregnant women with ZVD were reported in Colombia, with 1484 (12%) of these cases confirmed on RT-PCR assay. In a subgroup of 1850 pregnant women, more than 90% of women who were reportedly infected during the third trimester had given birth, and no infants with apparent abnormalities, including microcephaly, have been identified. A majority of the women who contracted ZVD in the first or second trimester were still pregnant at the time of this report. Among the cases of microcephaly investigated from January 2016 through April 2016, four patients had laboratory evidence of congenital ZVD; all were born to asymptomatic mothers who were not included in the ZVD surveillance system.



Preliminary surveillance data in Colombia suggest that maternal infection with the Zika virus during the third trimester of pregnancy is not linked to structural abnormalities in the fetus. However, the monitoring of the effect of ZVD on pregnant women in Colombia is ongoing. (Funded by Colombian Instituto Nacional de Salud and the Centers for Disease Control and Prevention.).
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Oscar
O
Pacheco
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Mauricio
M
Beltrán
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Christina A
CA
Nelson
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Diana
D
Valencia
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Natalia
N
Tolosa
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Sherry L
SL
Farr
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Ana V
AV
Padilla
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Van T
VT
Tong
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Esther L
EL
Cuevas
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Andrés
A
Espinosa-Bode
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Lissethe
L
Pardo
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Angélica
A
Rico
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Jennita
J
Reefhuis
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Maritza
M
González
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Marcela
M
Mercado
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Pablo
P
Chaparro
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Mancel
M
Martínez Duran
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Carol Y
CY
Rao
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
María M
MM
Muñoz
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Ann M
AM
Powers
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Claudia
C
Cuéllar
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Rita
R
Helfand
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Claudia
C
Huguett
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Denise J
DJ
Jamieson
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Margaret A
MA
Honein
From Instituto Nacional de Salud (O.P., M.B., N.T., A.V.P., E.L.C., L.P., A.R., M.G., M.M., P.C., M.M.D., C.H., M.L.O.M.) and Ministerio de Salud y Protección Social (M.M.M., C.C.) - both in Bogota, Colombia; and the Centers for Disease Control and Prevention, Atlanta (C.A.N., D.V., S.L.F., V.T.T., A.E.-B., J.R., C.Y.R., A.M.P., R.H., D.J.J., M.A.H.).
Martha L
ML
Ospina Martínez
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003105:Colombia / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D062306:Geography, Medical; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008831:Microcephaly / Q000453:epidemiology; D008875:Middle Aged; D011159:Population Surveillance; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology; D011263:Pregnancy Trimester, Third; D012367:RNA, Viral / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017678:Sex Distribution; D055815:Young Adult; D000071244:Zika Virus / Q000235:genetics / Q000302:isolation & purification*; D000071243:Zika Virus Infection / Q000453:epidemiology*
D012367:RNA, Viral