FKBP5 interacts with maltreatment in children with extreme, pervasive, and persistent aggression.
Genetic variation in stress response protein FKBP5 is associated with adult psychopathology, but little is known about its role in children's mental health. 5 polymorphisms were genotyped in 170 high aggression cases and 170 age- and sex-matched controls. The rs9470080 polymorphism was associated with physiological anxiety, while rs4713916 polymorphism interacted with maltreatment to influence externalizing traits. These results suggest that genetic variation in FKBP5 has a role in children's vulnerability to stress-related behaviours.
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address: lbryushkova@qmed.ca.
Lyubov
L
Bryushkova
Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Clement
C
Zai
Child, Youth, and Family Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Sheng
S
Chen
Generation R Study Group, Erasmus MC: University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Irene
I
Pappa
Generation R Study Group, Erasmus MC: University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Viara
V
Mileva
Generation R Study Group, Erasmus MC: University Medical Centre Rotterdam, Rotterdam, The Netherlands; Department of Child & Adolescent Psychiatry, Erasmus Medical Centre, Centre Rotterdam, Rotterdam, The Netherlands.
Henning
H
Tiemeier
Child and Family Studies, Leiden University, Leiden, The Netherlands.
Marian
M
Bakermans-Kranenburg
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
James L
JL
Kennedy
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Child, Youth, and Family Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Joseph H
JH
Beitchman
D000374:Aggression / Q000523:psychology*; D001007:Anxiety / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D002648:Child; D002649:Child Abuse / Q000523:psychology*; D005260:Female; D059647:Gene-Environment Interaction; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D022021:Tacrolimus Binding Proteins / Q000235:genetics*; D000099159:Tacrolimus Binding Protein 5
D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5
Child aggression; Gene-environment interaction; HPA axis