Why NAD(+) Declines during Aging: It's Destroyed.
NAD(+) is required not only for life but for a long life. In this issue, Camacho-Pereira et al. (2016) implicate CD38 in the decline of NAD(+) during aging, with implications for combating age-related diseases.
Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Michael B
MB
Schultz
Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Pharmacology, University of New South Wales, Sydney 2052, Australia. Electronic address: david_sinclair@hms.harvard.edu.
David A
DA
Sinclair
D051997:ADP-ribosyl Cyclase 1 / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009243:NAD / Q000378:metabolism*
D009243:NAD; D051997:ADP-ribosyl Cyclase 1