Evaluation of salivary interleukin-6 in children with early childhood caries after treatment.
BACKGROUND
The role of cytokines as a marker in the oral inflammatory process in ECC has not been fully explored before and after full mouth rehabilitation.


OBJECTIVE
The aim of this study was to assess the level of salivary interleukin-6 (IL-6) in children with ECC and to compare its levels before and after comprehensive full mouth rehabilitation.


METHODS
Saliva samples were collected from children with ECC prior to dental treatment and 3-month post treatment. The salivary IL-6 levels were analyzed using the ELISA method. The gingival index was also timely recorded. Oral health awareness sessions were conducted for children and their parents at regular intervals during the 3-month study period.


METHODS
Wilcoxon Signed Rank test compared the levels of salivary IL-6 while, the paired t test compared the values of gingival index before and after treatment.


RESULTS
The mean level of salivary IL-6 before and 3 months after treatment had reduced and this reduction was statistically significant (P < 0.000). The gingival index scores had also reduced significantly 3-months post treatment (P < 0.002).


CONCLUSIONS
Children with ECC when completely rehabilitated and kept under frequent follow up, which includes reinforcement of oral hygiene measures and maintaining a low caries activity state, the level of inflammation (IL-6) can definitely be minimized and thereby improving the quality of life of affected children.
Department of Pedodontics and Preventive Dentistry, Amrita School of Dentistry, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.
Medhini Madhavan
MM
Menon
Department of Pedodontics and Preventive Dentistry, Amrita School of Dentistry, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.
R Varma
RV
Balagopal
Department of Biochemistry, Amrita School of Dentistry, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.
Krishnan
K
Sajitha
Department of Pedodontics and Preventive Dentistry, Amrita School of Dentistry, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.
Kumaran
K
Parvathy
Department of Pedodontics and Preventive Dentistry, Amrita School of Dentistry, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.
G Bhat
GB
Sangeetha
Department of Pedodontics and Preventive Dentistry, Amrita School of Dentistry, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.
X Mamachan
XM
Arun
Department of Pedodontics and Preventive Dentistry, Amrita School of Dentistry, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.
Janardhanan
J
Sureshkumar
Dental caries; early childhood caries; salivary interleukin-6