The safety of vandetanib for the treatment of thyroid cancer.
BACKGROUND
The tyrosine kinase inhibitor vandetanib was approved for use in 2012 for aggressive and symptomatic medullary thyroid cancer (MTC) in patients with unresectable locally advanced or metastatic disease. As the first effective systemic therapy for MTC, vandetanib is a major step forward and the phase III study suggests an important role for this agent. Trials have also been performed for its use in differentiated thyroid cancer (DTC) though it is not yet approved for use for this indication.


METHODS
The efficacy and safety of vandetanib is discussed. Studies suggest improvement in progression-free survival (PFS) without clear overall survival benefit but with manageable low grade toxicities and improved quality of life on therapy.


CONCLUSIONS
Vandetanib has an important role in the management of patients with progressive metastatic MTC. The use in patients with stable or asymptomatic disease has no proven benefit. The side effects can usually be managed with dose reduction, interruption, and/or specific symptomatic therapy.
a Department of Endocrinology , Royal North Shore Hospital , Sydney , NSW , Australia.|b Sydney Medical School , University of Sydney , Sydney , NSW , Australia.
Venessa H M
VH
Tsang
a Department of Endocrinology , Royal North Shore Hospital , Sydney , NSW , Australia.|b Sydney Medical School , University of Sydney , Sydney , NSW , Australia.
Bruce G
BG
Robinson
a Department of Endocrinology , Royal North Shore Hospital , Sydney , NSW , Australia.|b Sydney Medical School , University of Sydney , Sydney , NSW , Australia.
Diana L
DL
Learoyd
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy*; D018572:Disease-Free Survival; D006801:Humans; D010880:Piperidines / Q000009:adverse effects / Q000627:therapeutic use*; D047428:Protein Kinase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D011788:Quality of Life; D011799:Quinazolines / Q000009:adverse effects / Q000627:therapeutic use*; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D010880:Piperidines; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; C452423:vandetanib
Vandetanib; safety; side effect management; thyroid cancer; tyrosine kinase inhibitor