VITREOMACULAR ADHESION EVOLUTION WITH AGE IN HEALTHY HUMAN EYES.
OBJECTIVE
To quantify the changes in vitreomacular interactions that occur with normal aging in normal eyes.


METHODS
Spectral domain optical coherence tomography (SD-OCT, Spectralis; Heidelberg Engineering, Heidelberg, Germany) foveal scans of subjects with best corrected visual acuity better than 20/40 and no ocular pathology were included in the study. Each scan was analyzed to determine the status of vitreoretinal interface: complete vitreous adhesion, partial posterior vitreous detachment (PVD) with persistent vitreomacular adhesion (VMA), or complete PVD. Area of VMA was delineated using the Spectralis drawing tool and calculated in mm for each scan. Subjects, aged 10 years to 97 years, were divided into 9 age groups according to decade of life.


RESULTS
Five hundred and sixty-six SD-OCT scans were analyzed. Area of VMA (mm) decreased sigmoidally (R = 0.99) with each decade of life. With aging, percentage of PVD increased while percentage of complete adhesion decreased. Males were found to have significantly larger area of VMA (mm) compared with females in the fifth through eighth decades of life, P < 0.05.


CONCLUSIONS
Vitreomacular interface interactions throughout life are age and gender dependent. This adds to our current understanding of the normal aging process undergone by the vitreous, thereby providing assistance in the clinical differentiation between normal and pathologic vitreomacular interactions.
*Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky; †University of Louisville School of Medicine, Louisville, Kentucky; ‡Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York; §DuPont Manual High School, Louisville, Kentucky; and ¶Department of Ophthalmology and Visual Sciences, University of Massachusetts School of Medicine, Worcester, Massachusetts.
Agustina C
AC
Palacio
Akash
A
Gupta
Brooke Lw
BL
Nesmith
Puja R
PR
Jadav
Yam
Y
Schaal
Shlomit
S
Schaal
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology / Q000502:physiology; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D000267:Tissue Adhesions / Q000503:physiopathology*; D041623:Tomography, Optical Coherence; D014822:Vitreous Body / Q000473:pathology*; D020255:Vitreous Detachment / Q000503:physiopathology*; D055815:Young Adult