AMPA/NMDA cooperativity and integration during a single synaptic event.
Coexistence of AMPA and NMDA receptors in glutamatergic synapses leads to a cooperative effect that can be very complex. This effect is dependent on many parameters including the relative and absolute number of the two types of receptors and biophysical parameters that can vary among synapses of the same cell. Herein we simulate the AMPA/NMDA cooperativity by using different number of the two types of receptors and considering the effect of the spine resistance on the EPSC production. Our results show that the relative number of NMDA with respect to AMPA produces a different degree of cooperation which depends also on the spine resistance.
Istituto di Scienze Applicate e Sistemi Intelligenti del CNR, C/O Complesso Olivetti Via Campi Flegrei 34, 80078, Pozzuoli, (NA), Italy. vito.dimaio@cnr.it.
Vito
V
Di Maio
Istituto di Scienze Applicate e Sistemi Intelligenti del CNR, C/O Complesso Olivetti Via Campi Flegrei 34, 80078, Pozzuoli, (NA), Italy.
Francesco
F
Ventriglia
Istituto di Scienze Applicate e Sistemi Intelligenti del CNR, C/O Complesso Olivetti Via Campi Flegrei 34, 80078, Pozzuoli, (NA), Italy.
Silvia
S
Santillo
D019706:Excitatory Postsynaptic Potentials; D018698:Glutamic Acid; D006801:Humans; D008959:Models, Neurological; D016202:N-Methylaspartate; D018091:Receptors, AMPA / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate; D013569:Synapses; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D016202:N-Methylaspartate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
AMPA; AMPA/NMDA cooperativity; Glutamatergic synapse; LPT; NMDA; Spine resistance; Synaptic model