Primary Langerhans Cell Histiocytosis of the Vulva: Case Report and Review of the Literature.
Langerhans cell histiocytosis (LCH) of the vulva is rare and even moreso in postmenopausal women. Twenty-six cases of primary vulvar LCH have been described in the current literature, and only 8 cases are in postmenopausal women. We report an additional case of primary vulvar LCH in a 59-yr-old woman with subsequent multiorgan involvement. In this article, we briefly describe the clinical presentation, histopathological findings, and immunohistochemistry results of vulvar LCH. We want to emphasize the importance of recognizing this entity in a woman with vulvar lesions both for the clinician and the pathologist.
Departaments of Pathology (T.Z., R.G., K.G., M.A.R., D.R.) Dermatology (A.V.) Hematology (M.R.), Complejo Hospitalario de Navarra, Navarra, Spain.
Tamara
T
Zudaire
Rosa
R
Guarch
Ana
A
Valcayo
Kelly
K
García
Miguel Ángel
MÁ
Resano
Diego
D
Requena
Mercedes
M
Rodríguez
D014408:Biomarkers, Tumor; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D014844:Vulva / Q000473:pathology; D014845:Vulvar Diseases / Q000473:pathology*
D014408:Biomarkers, Tumor