Clinical analysis of cases of neonatal Streptococcus agalactiae sepsis.
With the advent of antibiotic resistance, pathogenic bacteria have become a major threat in cases of neonatal sepsis; however, guidelines for treatment have not yet been standardized. In this study, 15 cases of neonatal Streptococcus agalactiae sepsis from our hospital were retrospectively analyzed. Of these, nine cases showed early-onset and six cases showed late-onset sepsis. Pathogens were characterized by genotyping and antibiotic sensitivity tests on blood cultures. Results demonstrated that in cases with early-onset sepsis, clinical manifestations affected mainly the respiratory tract, while late-onset sepsis was accompanied by intracranial infection. Therefore, we suggest including a cerebrospinal fluid examination when diagnosing neonatal sepsis. Bacterial genotyping indicated the bacteria were mainly type Ib, Ia, and III S. agalactiae. We recommend treatment with penicillin or ampicillin, since bacteria were resistant to clindamycin and tetracycline. In conclusion, our results provide valuable information for the clinical treatment of S. agalactiae sepsis in neonatal infants.
Department of Neonatology, BaYi Children's Hospital Affiliated to the Clinical Medical College at Beijing Military General Hospital of Southern Medical University, Beijing, China.|Department of Neonatology, Longgang District Central Hospital of Shenzhen, Shenzhen, China.
S J
SJ
Zeng
Department of Oncology, Longgang District Central Hospital of Shenzhen, Shenzhen, China.
X S
XS
Tang
Department of Neonatology, BaYi Children's Hospital Affiliated to the Clinical Medical College at Beijing Military General Hospital of Southern Medical University, Beijing, China.|Department of Pediatrics, Chengdu Military Common Hospital, Chengdu, China.
W L
WL
Zhao
Department of Neonatology, Longgang District Central Hospital of Shenzhen, Shenzhen, China.
H X
HX
Qiu
Microbiological Laboratory, Longgang District Central Hospital of Shenzhen, Shenzhen, China.
H
H
Wang
Department of Neonatology, BaYi Children's Hospital Affiliated to the Clinical Medical College at Beijing Military General Hospital of Southern Medical University, Beijing, China.
Z C
ZC
Feng
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology; D005260:Female; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D008826:Microbial Sensitivity Tests; D011379:Prognosis; D012189:Retrospective Studies; D013290:Streptococcal Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology; D013292:Streptococcus agalactiae / Q000235:genetics
D000900:Anti-Bacterial Agents