Immunological Evasion in Glioblastoma.
Glioblastoma is the most aggressive tumor in Central Nervous System in adults. Among its features, modulation of immune system stands out. Although immune system is capable of detecting and eliminating tumor cells mainly by cytotoxic T and NK cells, tumor microenvironment suppresses an effective response through recruitment of modulator cells such as regulatory T cells, monocyte-derived suppressor cells, M2 macrophages, and microglia as well as secretion of immunomodulators including IL-6, IL-10, CSF-1, TGF-β, and CCL2. Other mechanisms that induce immunosuppression include enzymes as indolamine 2,3-dioxygenase. For this reason it is important to develop new therapies that avoid this immune evasion to promote an effective response against glioblastoma.
Neuroimmunology and Neurooncology Unit, The National Institute of Neurology and Neurosurgery (NINN), Insurgentes Sur 3877, 14269 Mexico City, DF, Mexico.
Roxana
R
Magaña-Maldonado
Neuroimmunology and Neurooncology Unit, The National Institute of Neurology and Neurosurgery (NINN), Insurgentes Sur 3877, 14269 Mexico City, DF, Mexico.
Elda Georgina
EG
Chávez-Cortez
Neuroimmunology and Neurooncology Unit, The National Institute of Neurology and Neurosurgery (NINN), Insurgentes Sur 3877, 14269 Mexico City, DF, Mexico.
Nora Karen
NK
Olascoaga-Arellano
Neuroimmunology and Neurooncology Unit, The National Institute of Neurology and Neurosurgery (NINN), Insurgentes Sur 3877, 14269 Mexico City, DF, Mexico.
Mariana
M
López-Mejía
Neuroimmunology and Neurooncology Unit, The National Institute of Neurology and Neurosurgery (NINN), Insurgentes Sur 3877, 14269 Mexico City, DF, Mexico.
Fernando Manuel
FM
Maldonado-Leal
Neuroimmunology and Neurooncology Unit, The National Institute of Neurology and Neurosurgery (NINN), Insurgentes Sur 3877, 14269 Mexico City, DF, Mexico.
Julio
J
Sotelo
Neuroimmunology and Neurooncology Unit, The National Institute of Neurology and Neurosurgery (NINN), Insurgentes Sur 3877, 14269 Mexico City, DF, Mexico.
Benjamín
0000-0002-1455-312X
B
Pineda
D000818:Animals; D001921:Brain / Q000276:immunology*; D001932:Brain Neoplasms / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D005909:Glioblastoma / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D018448:Models, Immunological; D019139:Tumor Escape / Q000276:immunology*
D016207:Cytokines