Synthesis of 2-Alkynoates by Palladium(II)-Catalyzed Oxidative Carbonylation of Terminal Alkynes and Alcohols.
A homogeneous Pd(II) catalyst, utilizing a simple and inexpensive amine ligand (TMEDA), allows 2-alkynoates to be prepared in high yields by an oxidative carbonylation of terminal alkynes and alcohols. The catalyst system overcomes many of the limitations of previous palladium carbonylation catalysts. It has an increased substrate scope, avoids large excesses of alcohol substrate and uses a desirable solvent. The catalyst employs oxygen as the terminal oxidant and can be operated under safer gas mixtures.
School of Chemistry and Chemical Engineering, Queen's University Belfast, Stranmillis Road, Belfast, BT9 5AG, Northern Ireland.
Qun
http://orcid.org/0000-0002-1726-7225
Q
Cao
School of Chemistry and Chemical Engineering, Queen's University Belfast, Stranmillis Road, Belfast, BT9 5AG, Northern Ireland.
N Louise
http://orcid.org/0000-0001-5172-826X
NL
Hughes
School of Chemistry and Chemical Engineering, Queen's University Belfast, Stranmillis Road, Belfast, BT9 5AG, Northern Ireland. m.j.muldoon@qub.ac.uk.
Mark J
http://orcid.org/0000-0002-9286-9672
MJ
Muldoon
alkynes; carbonylation; homogeneous catalysis; oxidation; palladium