Amphotericin B liposome-induced acrocyanosis and elevated serum creatinine.
A 77-year-old male patient developed acrocyanosis and pain after treatment with amphotericin B liposome 150 mg daily intravenously for disseminated histoplasmosis, and subsequently developed elevated serum creatinine. Amphotericin B liposome was discontinued, and anisodamine was used intravenously to treat acrocyanosis and pain induced by amphotericin B liposome for 9 days and patient was cured. Naranjo adverse drug reaction probability scale score was 5, the World Health Organization-Uppsala Monitoring Centre criteria: Probable, indicating a probable adverse reaction to amphotericin B liposome.
Department of Pharmacy, Hangzhou Red Cross Hospital, Hangzhou 310003, China.
Xiangcai
X
Zhang
Department of Pharmacy, Hangzhou Red Cross Hospital, Hangzhou 310003, China.
Jie
J
Jin
Department of Respiration, Hangzhou Red Cross Hospital, Hangzhou 310003, China.
Chuang
C
Cai
Department of Pharmacy, Hangzhou Red Cross Hospital, Hangzhou 310003, China.
Ren
R
Zheng
Department of Pharmacy, Hangzhou Red Cross Hospital, Hangzhou 310003, China.
Yu
Y
Wang
Department of Pharmacy, Hangzhou Red Cross Hospital, Hangzhou 310003, China.
Yingying
Y
Xu
D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage*; D003404:Creatinine / Q000097:blood*; D006801:Humans; D008081:Liposomes; D008297:Male
D008081:Liposomes; D000666:Amphotericin B; D003404:Creatinine
Acrocyanosis; amphotericin B liposome; histoplasmosis; impaired renal function; pain