The life history of neochromosomes revealed.
Neochromosomes are a little-studied class of chromosome-scale mutations that drive some cancers. By sequencing isolated neochromosomes from liposarcomas, we recently defined their structure at single-nucleotide resolution and proposed a model for their life history. Here, we summarize that work, highlighting significant aspects and providing historical context and insight into the discovery process.
Bioinformatics Division; The Walter & Eliza Hall Institute of Medical Research; Parkville, Australia; Peter MacCallum Cancer Centre; East Melbourne, Australia; Department of Medical Biology; University of Melbourne; Melbourne, Australia; Sir Peter MacCallum Department of Oncology; University of Melbourne; Melbourne, Australia.
Anthony T
AT
Papenfuss
Peter MacCallum Cancer Centre; East Melbourne, Australia; The Kinghorn Cancer Centre, Garvan Institute of Medical Research; Sydney, Australia; University of New South Wales; Sydney, Australia.
David M
DM
Thomas
breakage-fusionbridge mechanism; cancer evolution; chromothripsis; computational modelling; liposarcoma; neochromosome