Prohibitin in Adipose and Immune Functions.
Prohibitin (PHB) was discovered in a quest to find genes with antiproliferative functions. However, the attribute of PHB that is responsible for its antiproliferative function remains elusive. Meanwhile, recent studies have established PHB as a pleiotropic protein with roles in metabolism, immunity, and senescence. PHB has cell compartment-specific functions, acting as a scaffolding protein in mitochondria, an adaptor molecule in membrane signaling, and a transcriptional coregulator in the nucleus. However, it remains unclear whether different functions and locations of PHB are interrelated or independent from each other, or if PHB works in a tissue-specific manner. Here, we discuss new findings on the role of PHB in adipose-immune interaction and an unexpected role in sex differences in adipose and immune functions.
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
Sudharsana R
SR
Ande
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
K Hoa
KH
Nguyen
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
B L Grégoire
BLG
Nyomba
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada. Electronic address: suresh.mishra@umanitoba.ca.
Suresh
S
Mishra
D050154:Adiposity / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D009765:Obesity / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D000091402:Prohibitins; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology / Q000502:physiology
C000717328:PHB protein, human; D000091402:Prohibitins; D012097:Repressor Proteins
adipose–immune interaction; autoimmune diabetes.; cancer; inflammation; obesity; sexually dimorphic