In vivo antiarthritic activity of Rosa centifolia L. flower extract.
BACKGROUND
Rosa centifolia L. (Rosaceae) have been used for the treatment of joint pain and rheumatoid arthritis (RA) in the traditional system of medicine.


OBJECTIVE
In this study, the antiarthritic activity of the alcoholic extract from the floral parts of R. centifolia was investigated.


METHODS
The anti-inflammatory and antiarthritic activity of R. centifolia alcoholic extract (RCAE: 32, 64, and 128 mg/kg) was evaluated using the carrageenan-induced paw edema and complete Freund's adjuvant (CFA) induced arthritis model. Serum from arthritic rats was collected for the estimation of pro-inflammatory cytokine levels. Further, the safety of RCAE was evaluated in an acute and sub-acute (28-day) oral toxicity study.


RESULTS
RCAE (64 and 128 mg/kg) significantly (P < 0.01) inhibited carrageenan-induced paw edema at 1, 3, and 6 h post carrageenan challenge and demonstrated significant (P < 0.01) antiarthritic activity on days 3, 7, 14, and 21 day following CFA immunization. Further, RCAE (128 mg/kg) treatment also produced a significant (P < 0.01) decrease in circulating pro-inflammatory cytokine levels as compared with control. Further, no toxicologically significant treatment-related effects were observed in the oral sub-acute toxicity study conducted with the extract.


CONCLUSIONS
The result of study demonstrates the antiarthritic activity of R. centifolia and validates its traditional use for the treatment of RA.
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
Rohit
R
Kumar
IPR Division-05, Evalueserve SEZ (Gurgoan) Pvt. Ltd., Gurgoan, Haryana, India.
Vinod
V
Nair
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
Surender
S
Singh
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
Yogendra Kumar
YK
Gupta
Arthritis; Rosa centifolia; Taruni; carrageenan; inflammation; quercetin