Ampicillin- and ampicillin/sulbactam-resistant Escherichia coli infection in a neonatal intensive care unit in Japan.
The incidence of ampicillin (ABPC)-resistant Escherichia coli (E. coli) infection in very low-birthweight infants has been increasing. The rate of ABPC/sulbactam (ABPC/SBT)-resistant E. coli in this population, however, is currently unknown. We encountered two cases of severe infection due to resistant E. coli and retrospectively studied the prevalence of ABPC- and ABPC/SBT-resistant E. coli in regular surveillance cultures obtained from all neonatal intensive care unit (NICU) patients between 2000 and 2013. The overall prevalence of ABPC-resistant E. coli was 39% (47/120), accounting for 63% of cases (32/51) between 2007 and 2013, compared with 22% (15/69) between 2000 and 2006. The prevalence of ABPC/SBT resistance was 17% (20/120), which was similar in both periods (16%, 8/51 vs 17%, 12/69). According to these results, not only ABPC, but also ABPC/SBT-resistant E. coli must be considered in the NICU.
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
Ken
K
Saida
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
Yukako
Y
Ito
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
Yosuke
Y
Shima
Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Eriko
E
Kasuga
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
Mai
M
Kusakari
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
Yukihide
Y
Miyosawa
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
Atsushi
A
Baba
D000367:Age Factors; D000667:Ampicillin / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data*; D007564:Japan / Q000453:epidemiology; D008297:Male; D013407:Sulbactam / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D000667:Ampicillin; D013407:Sulbactam
Escherichia coli; ampicillin; ampicillin/sulbactam; neonatal intensive care unit; prevalence