Synthesis and biological activities of novel 1,3,4-thiadiazole-containing pyrazole oxime derivatives.
A new library of 1,3,4-thiadiazole-containing pyrazole oximes was designed and synthesized. Their acaricidal and insecticidal activities were evaluated. Bioassay results indicated that some target compounds exhibited good acaricidal and insecticidal properties. Especially, compound 8m had 80% acaricidal activity against Tetranychus cinnabarinus at the concentration of 50μg/mL, compound 8f displayed 100% insecticidal activities against Aphis craccivora at the concentration of 50μg/mL, compounds 8r and 8w showed 100% insecticidal activities against Plutella xylostella at the concentration of 50μg/mL. Furthermore, compounds 8r (LC50=19.61μg/mL) and 8w (LC50=9.78μg/mL) possessed comparable or even better insecticidal activities than the control Pyridalyl (LC50=17.40μg/mL) against P. xylostella.
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, People's Republic of China.
Hong
H
Dai
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, People's Republic of China.
Gang
G
Li
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, People's Republic of China.
Jia
J
Chen
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, People's Republic of China. Electronic address: yjshi2015@163.com.
Yujun
Y
Shi
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, People's Republic of China.
Shushan
S
Ge
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, People's Republic of China.
Chongguang
C
Fan
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, People's Republic of China. Electronic address: gaohbhe2015@aliyun.com.
Haibing
H
He
D000818:Animals; D001042:Aphids / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009036:Moths / Q000187:drug effects*; D010091:Oximes / Q000737:chemistry / Q000494:pharmacology*; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D007306:Insecticides; D010091:Oximes; D011720:Pyrazoles; D013830:Thiadiazoles; C058949:1,3,4-thiadiazole
1,3,4-Thiadiazole; Bioactivity; Pyrazole oxime; Synthesis