An expanded role for mTORC1 in autophagy.
Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.
Department of Biochemistry; Molecular Biology, and Biophysics; University of Minnesota ; Minneapolis, MN USA.
Young-Mi
YM
Kim
Department of Biochemistry; Molecular Biology, and Biophysics; University of Minnesota ; Minneapolis, MN USA.
Ji-Man
JM
Park
Department of Biochemistry; Molecular Biology, and Biophysics; University of Minnesota ; Minneapolis, MN USA.
Douglas
D
Grunwald
Department of Biochemistry; Molecular Biology, and Biophysics; University of Minnesota; Minneapolis, MN USA; Masonic Cancer Center; University of Minnesota; Minneapolis, MN USA.
Do-Hyung
DH
Kim
RUBICON; UVRAG; autophagy; endosome; lysosome; mTOR; mTORC1