Aurora B kinase controls the separation of centromeric and telomeric heterochromatin.
The segregation of chromosomes is coordinated at multiple levels to prevent chromosome loss, a phenotype frequently observed in cancers. We recently described an essential role for telomeres in the physical separation of chromosomes and identified Aurora B kinase as a double agent involved in the separation of centromeric and telomeric heterochromatin.
Université de Toulouse, LBCMCP, 118 route de Narbonne, F-31062 Toulouse, France;; CNRS, LBCMCP-UMR5088, F-31062 Toulouse, France.
Yannick
Y
Gachet
Université de Toulouse, LBCMCP , 118 route de Narbonne , F-31062 Toulouse, France ;
Celine
C
Reyes
Université de Toulouse, LBCMCP, 118 route de Narbonne, F-31062 Toulouse, France;; CNRS, LBCMCP-UMR5088, F-31062 Toulouse, France.
Sylvie
S
Tournier
Aneuploidy; Aurora B kinase; HP1/Swi6; chromosome bi-orientation; chromosome instability; fission yeast; mitosis; telomere