Three new lignanosides from the aerial parts of Lespedeza cuneata.
Three new lignanosides (+)-(8S,7'S,8'S)-burselignan-9'-O-β-d-glucopyrano side (1), (+)-(8R,7'S,8'R)-isolariciresinol-9'-O-β-d-fucopyranoside (2), (-)-(8S, 7'R,8'R)-methoxyisoariciresinol-9'-O-α-l-rhamnoside (3), along with four known compounds, were isolated from the aerial parts of Lespedeza cuneata (Dum.Cours.) G.Don. The fucopyranoside has not been reported in this genus previously. Their structures and absolute configurations were elucidated on the basis of comprehensive spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with known analogues in the literature. Compounds 2 and 6 showed moderate hepatoprotective activities.
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
Chuang-Feng
CF
Zhang
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.|b Department of Pharmacy, The First Affiliated Hospital of Nanchang University , Nanchang 330006 , China.
Jian
J
Zhou
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
Jing-Zhi
JZ
Yang
Chuang-Jun
CJ
Li
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
Jie
J
Ma
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
Dan
D
Zhang
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
Li
L
Li
a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
Dong-Ming
DM
Zhang
D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D029884:Lespedeza / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008099:Liver / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry*; D013237:Stereoisomerism
C000613713:(8R,7'S,8'R)-isolariciresinol-9'-O-beta-D-fucopyranoside; C000613714:(8S,7'R,8'R)-methoxyisoariciresinol-9'-O-alpha-L-rhamnoside; C000613712:(8S,7'S,8'S)-burselignan-9'-O-beta-D-glucopyranoside; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D017705:Lignans
Lespedeza cuneata; hepatoprotective activities; lignanoside