PON1 L55M polymorphism might contribute to the risk of cancer.
BACKGROUND
The results involved in correlation of PON1 L55M polymorphism and cancer risk are still inconsistent and controversial. Therefore, we performed this comprehensive meta-analysis for the effects of PON1 L55M polymorphism and cancer risk.


METHODS
We carried out a database search in PubMed (Medline) and EMBASE covering all published articles. The strength of association between PON1 L55M polymorphism and cancer risk was estimated by pooled ORs with corresponding 95% confidence intervals (CI).


RESULTS
Twenty-one independent case-control studies concerned with association between PON1 L55M polymorphism and cancer risk were finally included in this meta-analysis. We found that there was a statistical significance between PON1 L55M polymorphism and cancer risk (OR=1.21, 95% CI: 1.04-1.40). In stratified analyses by site of cancer, statistically significant increased breast cancer risk was found (OR=2.04, 95% CI: 1.29-3.21). In stratified analyses by ethnicity, statistically significant increased cancer risk was found in Caucasian populations (OR=1.25, 95% CI: 1.03-1.51). In stratified analyses by source of control, significant increased cancer risk was found in hospital-based studies (OR=1.26, 95% CI: 1.10-1.44).


CONCLUSIONS
This meta-analysis suggested that PON1 L55M polymorphism might increase the risk of cancer.
Yidu Central Hospital, Weifang, China - peizengsd@163.com.|School of Medicine, Shandong University, Jinan, China - peizengsd@163.com.
Peizeng
P
Hu
Yidu Central Hospital, Weifang, China.|School of Medicine, Shandong University, Jinan, China.
Yongchen
Y
Ma
Shandong Province Rongjun Hospital, Weifang, China.
Lingling
L
Zhang
Yidu Central Hospital, Weifang, China.
Sheng
S
Ma
D000483:Alleles; D043303:Aryldialkylphosphatase / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D015203:Reproducibility of Results; D012307:Risk Factors
D043303:Aryldialkylphosphatase; C468406:PON1 protein, human