The NFE2L2 rs35652124 polymorphism and the risk of Parkinson's disease: a systematic review and meta-analysis.
The relationship between the nuclear factor erythroid-derived 2-like 2 (NFE2L2) rs35652124 (A/G) polymorphism and the risk of Parkinson's disease (PD) is controversial. To evaluate the association of the NFE2L2 rs35652124 polymorphism with the risk of PD, a meta-analysis was carried out. A total of 2264 PD cases and 2582 controls were included in the meta-analysis on the basis of strict inclusion and exclusion criteria. The pooled odds ratio (OR) and 95% confidence interval were calculated to assess the genetic association between the NFE2L2 rs35652124 polymorphism and the risk of PD. There was no significant association between rs35652124 and PD (G vs. A: OR=1.001, P=0.986; GG vs. AA: OR=1.026, P=0.785; GA vs. AA: OR=1.023, P=0.786; GG+GA vs. AA: OR=1.224, P=0.070; GG vs. GA+AA: OR=0.994, P=0.926). The data of our meta-analysis indicate that the G allele, GG, and GA genotype of the rs35652124 (A/G) polymorphism were not associated with the risk of PD.
aThe Second Department of Clinical Medicine, China Medical University, Shenyang bDepartment of Neurology, The First Affiliated Hospital of Dalian Medical University cDepartment of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Mengru
M
Zhu
TingTing
T
Zhou
Guo
G
Zu
ZhanHua
Z
Liang
D000483:Alleles; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D051267:NF-E2-Related Factor 2 / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human