Spatiotemporal plasticity of miRNAs functions: The miR-17-92 case.
The functional effect of a specific miRNA is tightly linked to the transcriptome, thus having the potential to elicit distinct outcomes in different cellular states. Our recent discovery of a dual role of the miR-17-92 cluster, which shifts from oncogene to tumor suppressor during lymphoma progression, exemplifies the spatiotemporal plasticity of miRNAs.
Department of Experimental Oncology, European Institute of Oncology , Milan, Italy.
Tiziana
T
Bonaldi
Department of Experimental Oncology, European Institute of Oncology , Milan, Italy.
Marija
M
Mihailovich
3´-UTR shortening; Alternative polyadenylation (APA); miR-17-92; miRNA