DNA damage tolerance branches out toward sister chromatid cohesion.
Genome duplication is temporarily coordinated with sister chromatid cohesion and DNA damage tolerance. Recently, we found that replication fork-coupled repriming is important for both optimal cohesion and error-free replication by recombination. The mechanism involved has implications for the etiology of replication-based genetic diseases and cancer.
IFOM, FIRC Institute of Molecular Oncology , Milan, Italy.
Dana
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Branzei
DNA damage tolerance; DNA replication; Developmental disorders; Polα/primase/Ctf4; mechanisms of oncogenesis and tumor progression; replication fork architecture; replication stress; repriming; sister chromatid cohesion