Regulation of chromatin structure and cell fate by R-loops.
Hybridization of RNA to its template DNA strand during transcription induces formation of R-loops-RNA:DNA hybrids with unpaired non-template DNA strands. Although unresolved R-loops can be detrimental, some R-loops contribute to regulation of chromatin structure. Consequently, R-loops help regulate gene expression and play important roles in numerous cellular processes.
a Department of Molecular, Cell, and Cancer Biology , University of Massachusetts Medical School , Worcester , MA , USA.|b Program in Molecular Medicine , University of Massachusetts Medical School , Worcester , MA , USA.
Thomas G
TG
Fazzio
D000818:Animals; D020029:Base Pairing; D002843:Chromatin / Q000235:genetics*; D042002:Chromatin Assembly and Disassembly; D004247:DNA / Q000737:chemistry / Q000235:genetics*; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D008745:Methylation; D009154:Mutation; D011485:Protein Binding; D012313:RNA / Q000737:chemistry / Q000235:genetics*
D002843:Chromatin; D004268:DNA-Binding Proteins; D006657:Histones; D012313:RNA; D004247:DNA
R-loops; chromatin; embryonic stem cells; nucleosome; pluripotency