Different macro- and micro-rheological properties of native porcine respiratory and intestinal mucus.
Aim of this study was to investigate the similarities and differences at macro- and microscale in the viscoelastic properties of mucus that covers the epithelia of the intestinal and respiratory tract. Natural mucus was collected from pulmonary and intestinal regions of healthy pigs. Macro-rheological investigations were carried out through conventional plate-plate rheometry. Microrheology was investigated using optical tweezers. Our data revealed significant differences both in macro- and micro-rheological properties between respiratory and intestinal mucus.
Department of Pharmacy, Saarland University, D-66123 Saarbrücken, Germany.
Harish
H
Bokkasam
Department of Engineering Sciences, Applied Mathematics, University of Applied Sciences, D-66117 Saarbrücken, Germany. Electronic address: matthias.ernst@htwsaar.de.
Matthias
M
Ernst
Department of Engineering Sciences, Applied Mathematics, University of Applied Sciences, D-66117 Saarbrücken, Germany.
Marco
M
Guenther
Department of Physics, Saarland University, D-66123 Saarbrücken, Germany.
Christian
C
Wagner
Department of Pharmacy, Saarland University, D-66123 Saarbrücken, Germany.
Ulrich F
UF
Schaefer
Department of Pharmacy, Saarland University, D-66123 Saarbrücken, Germany; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), D-66123 Saarbrücken, Germany.
Claus-Michael
CM
Lehr
D000818:Animals; D007413:Intestinal Mucosa / Q000737:chemistry / Q000502:physiology*; D009093:Mucus / Q000737:chemistry / Q000502:physiology*; D020545:Respiratory Mucosa / Q000737:chemistry / Q000502:physiology*; D012212:Rheology / Q000379:methods*; D013552:Swine
Inestine; Mucus; Optical tweezer; Rheology; Trachea; Viscoelastic properties