Stromal TGFβR2 signaling: a gateway to progression for pancreatic cancer.
The function of transforming growth factor β (TGFβ) in the progression of pancreatic ductal adenocarcinoma (PDA) is complex and therapeutic targeting of this pathway is challenging. We showed that antibody-mediated inhibition of stromal Tgfβr2 prevented or reversed epithelial plasticity resulting in a potent reduction of metastasis in xenograft models of PDA.
Division of Surgical Oncology; Department of Surgery and Hamon Center for Therapeutic Oncology Research; University of Texas Southwestern Medical Center ; Dallas, TX USA.
Moriah M
MM
Hagopian
Division of Surgical Oncology; Department of Surgery and Hamon Center for Therapeutic Oncology Research; University of Texas Southwestern Medical Center ; Dallas, TX USA.
Rolf A
RA
Brekken
TGF-β; epithelial to mesenchymal transition; metastasis; pancreatic cancer; tumor–stroma interactions