What Have Metabolomics Approaches Taught Us About Type 2 Diabetes?
Type 2 diabetes (T2D) is increasing worldwide, making identification of biomarkers for detection, staging, and effective prevention strategies an especially critical scientific and medical goal. Fortunately, advances in metabolomics techniques, together with improvements in bioinformatics and mathematical modeling approaches, have provided the scientific community with new tools to describe the T2D metabolome. The metabolomics signatures associated with T2D and obesity include increased levels of lactate, glycolytic intermediates, branched-chain and aromatic amino acids, and long-chain fatty acids. Conversely, tricarboxylic acid cycle intermediates, betaine, and other metabolites decrease. Future studies will be required to fully integrate these and other findings into our understanding of diabetes pathophysiology and to identify biomarkers of disease risk, stage, and responsiveness to specific treatments.
Research Division, 1 Joslin Place, Boston, MA, 02215, USA.
Alba
A
Gonzalez-Franquesa
Research Division, 1 Joslin Place, Boston, MA, 02215, USA.
Alison M
AM
Burkart
Research Division, 1 Joslin Place, Boston, MA, 02215, USA.
Elvira
E
Isganaitis
Research Division, 1 Joslin Place, Boston, MA, 02215, USA. mary.elizabeth.patti@joslin.harvard.edu.
Mary-Elizabeth
ME
Patti
D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism*; D004777:Environment; D016678:Genome; D006801:Humans; D055442:Metabolome / Q000235:genetics; D055432:Metabolomics / Q000379:methods*; D012307:Risk Factors
Insulin resistance; Insulin secretion; Metabolomics; Type 2 diabetes