[Expressions of DAPK3 and c-Myc in endometrial cancer and their relationship with the patients' prognosis].
OBJECTIVE
To investigate the expressions of DAPK3 and c-Myc and their prognostic value in endometrial carcinoma (EC).


METHODS
The expressions of DAPK3 and c-Myc were detected immunohistochemically in 132 surgical specimens. The relationship between DAPK3 and c-Myc protein expressions and the clinicopathological features of the patients was evaluated.


RESULTS
Immunohistochemical analysis revealed low DAPK3 expression in 60.61% (80/132) and high c-Myc expression in 53.79% (71/132) of the specimens of EC. Both DAPK3 expression and c-Myc expression were significantly correlated with FIGO stage (P=0.034 and 0.015, respectively) and lymph node metastasis (P=0.022 and 0.031, respectively). DAPK3 expression was closely correlated with the histological grade (P=0.027) and depth of myometrial invasion (P=0.011). Kaplan-Meier survival analysis indicated that patients with low DAPK3 expressions had a shorter overall survival rate than those with high DAPK3 expressions (P=0.023), while patients with high c-Myc expressions had poorer prognoses than those with low c-Myc expressions (P=0.002). Spearman correlation analysis showed that DAPK3 and c-Myc expressions were negatively correlated (P<0.001, r=?0.310). Multivariate analysis identified a high c-Myc expression as the independent predictor of the prognosis of EC (P=0.007).


CONCLUSIONS
A low expression of DAPK3 and a high expression of c-Myc are associated with aggressive and metastatic behaviors of EC, and their detection may help to predict the prognosis of the EC patients.
Department of Obstetrics and Gynecology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. E-mail: chenyuxin6049@163.com.
Chen
C
Chen
Sui-Qun
SQ
Guo
D064550:Death-Associated Protein Kinases / Q000378:metabolism*; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D015996:Survival Rate
D016271:Proto-Oncogene Proteins c-myc; C579101:DAPK3 protein, human; D064550:Death-Associated Protein Kinases