Microenvironment-Driven Bioelimination of Magnetoplasmonic Nanoassemblies and Their Multimodal Imaging-Guided Tumor Photothermal Therapy.
Biocompatibility and bioelimination are basic requirements for systematically administered nanomaterials for biomedical purposes. Gold-based plasmonic nanomaterials have shown potential applications in photothermal cancer therapy. However, their inability to biodegrade has impeded practical biomedical application. In this study, a kind of bioeliminable magnetoplasmonic nanoassembly (MPNA), assembled from an Fe3O4 nanocluster and gold nanoshell, was elaborately designed for computed tomography, photoacoustic tomography, and magnetic resonance trimodal imaging-guided tumor photothermal therapy. A single dose of photothermal therapy under near-infrared light induced a complete tumor regression in mice. Importantly, MPNAs could respond to the local microenvironment with acidic pH and enzymes where they accumulated including tumors, liver, spleen, etc., collapse into small molecules and discrete nanoparticles, and finally be cleared from the body. With the bioelimination ability from the body, a high dose of 400 mg kg(-1) MPNAs had good biocompatibility. The MPNAs for cancer theranostics pave a way toward biodegradable bio-nanomaterials for biomedical applications.
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences , National Center for Nanoscience and Technology (NCNST), Beijing 100083, People's Republic of China.
Linlin
L
Li
Mineral Resources Chemistry Key Laboratory of Sichuan Higher Education Institutions, College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology , Chengdu 610059, People's Republic of China.
Shiyan
S
Fu
Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences , Beijing 100190, People's Republic of China.
Chuanfang
C
Chen
Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences , Xiamen 361021, People's Republic of China.
Xuandong
X
Wang
Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Beijing 100190, People's Republic of China.
Changhui
C
Fu
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences , National Center for Nanoscience and Technology (NCNST), Beijing 100083, People's Republic of China.
Shu
S
Wang
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences , National Center for Nanoscience and Technology (NCNST), Beijing 100083, People's Republic of China.
Weibo
W
Guo
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences , National Center for Nanoscience and Technology (NCNST), Beijing 100083, People's Republic of China.
Xin
X
Yu
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences , National Center for Nanoscience and Technology (NCNST), Beijing 100083, People's Republic of China.
Xiaodi
X
Zhang
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences , National Center for Nanoscience and Technology (NCNST), Beijing 100083, People's Republic of China.
Zhirong
Z
Liu
State Key Laboratory of Crystal Materials, Shandong University , Jinan 250100, People's Republic of China.
Jichuan
J
Qiu
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences , National Center for Nanoscience and Technology (NCNST), Beijing 100083, People's Republic of China.|State Key Laboratory of Crystal Materials, Shandong University , Jinan 250100, People's Republic of China.
Hong
H
Liu
D000818:Animals; D006046:Gold; D051379:Mice; D064847:Multimodal Imaging; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy; D010789:Phototherapy; D000068936:Theranostic Nanomedicine
D006046:Gold
biocompatibility; bioelimination; multimodal imaging; photothermal therapy; plasmonic nanoparticles