Chronic and gestational metabolic disorders have a different impact on late-pregnancy endothelial function in pregnant women.
We investigated how maternal endothelial function is affected by pregestational (Type 1) diabetes mellitus (PGDM) or gestational diabetes mellitus (GDM) and/or chronic hypertension (chHT) or gestational hypertension (PIH).



We conducted a prospective, observational study involving 78 participants with GDM, PGDM and/or hypertension (PIH-16, GDM + PIH-14, PGDM + chHT-8, PGDM-20, GDM-20) in the third trimester of a singleton viable pregnancy. Twenty healthy women with uncomplicated pregnancies matched for gestational age served as controls. We analysed maternal data, disease history and serum concentrations of E-selectin and Vascular cell adhesion molecule 1 (sVCAM-1).



Only the maternal serum concentration of sVCAM-1 differed significantly among the subgroups (p< 0.0001), with the highest levels evident in women with PIH or GDM + PIH and the lowest in women with PGDM alone or PGDM + chHT.



Pregestational or pregnancy associated disorders, although sharing similar clinical symptoms, have a different impact on endothelial function in pregnant women.
agazaw@post.pl.
Agnieszka
A
Zawiejska
Ewa
E
Wender-Ożegowska
Jacek
J
Brazert
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D008659:Metabolic Diseases / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D012307:Risk Factors; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*; D055815:Young Adult
D015415:Biomarkers; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1
cell adhesion molecules; hypertension; pregnancy; type 1 diabetes; vascular endothelium