Perinatal outcome in fresh versus frozen embryo transfer in ART cycles.
BACKGROUND
Despite of higher pregnancy rate after frozen embryo transfer (FET) which is accepted by the majority of researches, the safety of this method and its effect on neonatal outcome is still under debate.


OBJECTIVE
The aim of this study was to evaluate pregnancy and neonatal outcome of FET compare to fresh cycles.


METHODS
In this study,1134 patients using fresh ET and 285 women underwent FET were investigated regarding live birth as primary outcome and gestational age, birth weight, gender, multiple status, ectopic pregnancy, still birth and pregnancy loss as secondary outcomes.


RESULTS
Our results showed that there is no difference between FET and fresh cycles regarding live birth (65.6% vs. 70.4% respectively). Ectopic pregnancy, still birth and abortion were similar in both groups. The mean gestational age was significantly lower among singletons in FET group compared to fresh cycles (p=0.047). Prematurity was significantly elevated among singleton infants in FET group (19.6%) in comparison to neonates born after fresh ET (12.8%) (p=0.037).


CONCLUSIONS
It seems that there is no major difference regarding perinatal outcome between fresh and frozen embryo transfer. Although, live birth is slightly increased in fresh cycles and prematurity was significantly increased among singleton infants in FET group.
Madar Hospital, Yazd, Iran.
Ali
A
Aflatoonian
Madar Hospital, Yazd, Iran.
Mohammad Ali
MA
Karimzadeh Maybodi
Madar Hospital, Yazd, Iran.
Nastaran
N
Aflatoonian
Infertility Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Nasim
N
Tabibnejad
Madar Hospital, Yazd, Iran.
Mohammad Hossein
MH
Amir-Arjmand
Infertility Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mehrdad
M
Soleimani
Madar Hospital, Yazd, Iran.; Stem Cell Biology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Behrouz
B
Aflatoonian
Infertility Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abbas
A
Aflatoonian
Fresh embryo transfer; Frozen-thawed embryo transfer; Perinatal outcome; Pregnancy outcome