Wiring dendrites in layers and columns.
The most striking structure in the nervous system is the complex yet stereotyped morphology of the neuronal dendritic tree. Dendritic morphologies and the connections they make govern information flow and integration in the brain. The fundamental mechanisms that regulate dendritic outgrowth and branching are subjects of extensive study. In this review, we summarize recent advances in the molecular and cellular mechanisms for routing dendrites in layers and columns, prevalent organizational structures in the brain. We highlight how dendritic patterning influences the formation of synaptic circuits.
a Section on Neuronal Connectivity, Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development , Bethesda , MD , USA ;
Jiangnan
J
Luo
b Mathematical and Statistical Computing Laboratory, Office of Intramural Research, Center for Information Technology , National Institutes of Health , Bethesda , MD , USA ;
Philip G
PG
McQueen
a Section on Neuronal Connectivity, Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development , Bethesda , MD , USA ;|c Biological Sciences Graduate Program, College of Computer, Mathematical, and Natural Sciences , University of Maryland , College Park , MD , USA.
Bo
B
Shi
a Section on Neuronal Connectivity, Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development , Bethesda , MD , USA ;
Chi-Hon
CH
Lee
a Section on Neuronal Connectivity, Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development , Bethesda , MD , USA ;
Chun-Yuan
CY
Ting
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D001921:Brain / Q000648:ultrastructure*; D063132:Connectome / Q000379:methods; D003712:Dendrites / Q000648:ultrastructure*; D006801:Humans
Circuit assembly; dendrite development; layer and column; synaptic circuits