Visualization of Grossly Undetectable Breast Tumors by Refixation in Lymph Node Revealing Solution.
Introduction Breast lesions might be missed by the traditional method of inspection, palpation, and sectioning of the specimen. Lymph node revealing solution (LNRS) was first introduced by us as a fixative that enhances the retrieval of lymph nodes in breast carcinoma and other malignancies. This is a preliminary report of our experience with the use of LNRS in order to visualize malignant breast tumors that were not detected by the traditional method. Material and Methods Eight post-chemoradiation-treated tumors, 6 relumpectomy specimens, and 1 post mammotome lumpectomy with no grossly detectable residual tumor and 2 mastectomy specimens with multifocal tumors which were missed by the first inspection were postfixed in LNRS for 24 hours and sectioned. Results In some of the cases, small tumors up to 0.5 cm were visualized as white gray lesions. Carcinoma has been confirmed by histopathologic examination and the final diagnosis had to be changed. Conclusion Postfixation in LNRS enhances the visualization of grossly undetectable breast lesions and it is worthwhile to use it in problematic cases in order to arrive at a more accurate diagnosis.
St George's University of London, University of Nicosia, Nicosia, Cyprus bubisgolan@gmail.com.
Golan
G
Bubis
Rabin Medical Center, Hasharon Hospital, Petah-Tiqva, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Lea
L
Rath-Wolfson
Rabin Medical Center, Hasharon Hospital, Petah-Tiqva, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Ariel
A
Schwartz
Rabin Medical Center, Hasharon Hospital, Petah-Tiqva, Israel.
Sasha
S
Girich
Rabin Medical Center, Hasharon Hospital, Petah-Tiqva, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Rumelia
R
Koren
D019342:Acetic Acid; D000071960:Breast Carcinoma In Situ / Q000175:diagnosis*; D001943:Breast Neoplasms / Q000175:diagnosis*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis*; D000431:Ethanol; D004986:Ether; D005260:Female; D005557:Formaldehyde; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D016707:Tissue Fixation / Q000379:methods*
C119829:lymph node revealing solution; D004986:Ether; D005557:Formaldehyde; D000431:Ethanol; D019342:Acetic Acid
Visualization; lymph node revealing solution (LNRS); pathologic complete response; small breast tumors