Redox regulation of Smac mimetic-induced cell death.
Cell death and survival programs are controlled by the cellular redox state, which is typically dysregulated during oncogenesis. A recent study reports that the inhibition of antioxidant defenses resulting from glutathione depletion can prime acute lymphoblastic leukemia cells for death induced by Smac mimetics.
Institute for Experimental Cancer Research in Pediatrics; Goethe-University ; Frankfurt, Germany.
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Fulda
Smac; apoptosis; cell death; leukemia; redox