Interleukin 12B gene polymorphisms and susceptibility to rheumatoid arthritis: a data synthesis.
The aim of this study was to investigate the association of two common interleukin 12B (IL-12B) polymorphisms (rs3212227 and rs6887695) with rheumatoid arthritis (RA) susceptibility through meta-analyses. A systematic literature search of PubMed, Web of Science, Cochrane Library, and Embase databases was conducted on articles published before 28 February 2016. Then odds ratio (OR) with 95 % confidence interval (CI) was used to quantify the strength of association for homozygote, heterozygote, dominant, and recessive genetic models. Nine articles with a total of 17 case-control studies (12 for IL-12B rs3212227 polymorphism and 5 for IL-12B rs6887695 polymorphism) met our inclusion criteria. The pooled results demonstrated that IL-12B rs3212227 (homozygote model: OR = 0.96, 95 % CI = 0.81-1.15; heterozygote model: OR = 1.07, 95 % CI = 0.93-1.23; dominant model: OR = 1.05, 95 % CI = 0.91-1.20; recessive model: OR = 0.93, 95 % CI = 0.79-1.10) and rs6887695 (homozygote model: OR = 1.01, 95 % CI = 0.84-1.21; heterozygote model: OR = 1.14, 95 % CI = 0.86-1.51; dominant model: OR = 1.14, 95 % CI = 0.87-1.48; recessive model: OR = 1.01, 95 % CI = 0.85-1.21) polymorphisms may not be associated with RA risk. Our meta-analyses demonstrated that IL-12B rs3212227 and rs6887695 polymorphisms do not confer susceptibility to RA.
School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China. yangxiaoqin@suda.edu.cn.
Xiaoqin
X
Yang
School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.
Fei
F
Xiao
School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.
Dan
D
Luo
Department of Pharmacy, College of Health sciences, Guangzhou Medical University, Guangzhou, China.
Guiping
G
Wang
Scotch Plains, New Jersey, USA. itshuang@gmail.com.
Shuang
S
Liang
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D053762:Interleukin-12 Subunit p40 / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide
C500879:IL12B protein, human; D053762:Interleukin-12 Subunit p40
IL-12B; Meta-analysis; Polymorphism; Rheumatoid arthritis