Oncogenic long noncoding RNA FAL1 in human cancer.
Long non-coding RNAs (lncRNAs) are defined as RNA transcripts larger than 200 nucleotides that do not appear to have protein-coding potential. Accumulating evidence indicates that lncRNAs are involved in tumorigenesis. Our work reveals that lncRNA FAL1 (focally amplified lncRNA on chromosome 1) is frequently and focally amplified in human cancers and mediates oncogenic functions.
Center for Stem Cell Biology and Tissue Engineering; Department of Biology; Zhongshan School of Medicine; Sun Yat-Sen University; Guangzhou, China; Department of Obstetrics and Gynecology; Perelman School of Medicine; University of Pennsylvania; Philadelphia, PA USA.
Xiaomin
X
Zhong
Department of Obstetrics and Gynecology; Perelman School of Medicine ; University of Pennsylvania ; Philadelphia, PA USA.
Xiaowen
X
Hu
Department of Obstetrics and Gynecology; Perelman School of Medicine ; University of Pennsylvania ; Philadelphia, PA USA.
Lin
L
Zhang
cancer; long noncoding RNA; somatic copy number alterations