Contrast-enhanced magnetic resonance pancreatography with gadoteridol by heavily T2-weighted three-dimensional fluid-attenuated inversion recovery: preliminary results in healthy subjects.
The purpose of this study was to investigate the feasibility of contrast-enhanced magnetic resonance (MR) pancreatography with intravenously administered gadolinium-based contrast material (GBCM) in healthy subjects. Eight healthy male subjects (age: 29-53 years old, median: 37 years old) were enrolled. Contrast-enhanced MR pancreatography was scanned with heavily T2-weighted three-dimensional fluid-attenuated inversion recovery (hT2W-3D-FLAIR) before and after intravenous GBCM administration. Two radiologists evaluated the images, referring to three-dimensional MR pancreatography by consensus. Scanning was performed five times at 1.5-h intervals (at 0.5, 2, 3.5, 5, and 6.5 h) after GBCM administration. In all subjects, pre-contrast-enhanced hT2W-3D-FLAIR images demonstrated no visualization of the main pancreatic duct. After GBCM administration, the main pancreatic duct was visualized in all subjects at 0.5 h (n=4, 50%) and/or 2 h (n=7, 88%). The mean signal intensity of the main pancreatic duct was 3.17 ± 0.78 at pre-contrast enhancement, 7.96 ± 4.60 at 0.5 h, and 8.08 ± 4.64 at 2 h. The signal intensity ratio of the main pancreatic duct against the pancreatic parenchyma was statistically higher (P < 0.01) at the 0.5-h and 2-h scans than that of pre-contrast-enhanced scan. Intravenously administered GBCM seeped into the pancreatic duct in sufficient concentration to alter the appearance of the main pancreatic duct by hT2W-3D-FLAIR in healthy subjects.
Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kojiro
K
Suzuki
Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shinji
S
Naganawa
Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Naohiro
N
Furuhashi
Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Masahiro
M
Yamazaki
Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hiroshi
H
Ogawa
Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hisashi
H
Kawai
D000328:Adult; D003287:Contrast Media; D005682:Gadolinium; D064368:Healthy Volunteers; D006571:Heterocyclic Compounds; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium
contrast material; magnetic resonance imaging; pancreas; pancreatography