Death by a thousand knives: Multiple BH3-only proteins are required for maximal apoptosis triggered through the BCR.
The B-cell receptor (BCR) represents a key driver of B-cell development. Consequently, multiple mechanisms link inappropriate BCR signaling to apoptosis. Recently, we characterized the molecular regulators involved in lymphoma cells, confirming a major role for Bcl-2 interacting mediator of cell death (Bim) and supplementary roles for Bcl-2 interacting killer (Bik) and Noxa, and showing that all 3 proteins are required for maximal apoptosis.
Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton, Faculty of Medicine , Tremona Road , Southampton, United Kingdom.
Matthew J
MJ
Carter
Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton, Faculty of Medicine , Tremona Road , Southampton, United Kingdom.
Mark S
MS
Cragg
Apoptosis; B-cell receptor (BCR); BCL2; BH3-only; Bik; Bim; Noxa; mitochondrial outer membrane permeabilization (MOMP)