Association of RSV-A ON1 genotype with Increased Pediatric Acute Lower Respiratory Tract Infection in Vietnam.
Since the initial discovery of RSV-A ON1 in Canada in 2010, ON1 has been reported worldwide, yet information regarding its clinical impact and severity has been controversial. To investigate the clinical relevance of RSV-A ON1,acute respiratory infection (ARI) cases enrolled to our population-based prospective pediatric ARI surveillance at Khanh Hoa General Hospital, Central Vietnam from January 2010 through December 2012 were studied. Clinical-epidemiological information and nasopharyngeal samples were collected. Multiplex PCR assays were performed for screening 13 respiratory viruses. RSV-positive samples were further tested for subgroups (A/B) and genotypes information by sequencing the G-glycoprotein 2nd hypervariable region. Statistical analysis was performed to evaluate the clinical-epidemiological characteristics of RSV-A ON1. A total of 1854 ARI cases were enrolled and 426 (23.0%) of them were RSV-positive. During the study period, RSV-A and B had been co-circulating. NA1 was the predominant RSV-A genotype until the appearance of ON1 in 2012. RSV-related ARI hospitalization incidence significantly increased after the emergence of ON1. Moreover, multivariate analysis revealed that risk of lower respiratory tract infection was 2.26 (95% CI: 1.37-3.72) times, and radiologically-confirmed pneumonia was 1.98 (95% CI: 1.01-3.87) times greater in ON1 compared to NA1 cases. Our result suggested that ON1 ARI cases were clinically more severe than NA1.
Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.|Leading Program, Graduate School of Biomedical Science, Nagasaki University, Nagasaki, 852-8523, Japan.
Keisuke
K
Yoshihara
Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.|National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
Minh Nhat
MN
Le
Department of Virology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan.
Michiko
M
Okamoto
Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.
Anita Carolle Akpeedje
AC
Wadagni
National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
Hien Anh
HA
Nguyen
Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.|Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8523, Japan.
Michiko
M
Toizumi
Khanh Hoa General Hospital, Nha Trang, Vietnam.
Enga
E
Pham
Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.
Motoi
M
Suzuki
Khanh Hoa General Hospital, Nha Trang, Vietnam.
Ai Thi Thuy
AT
Nguyen
Department of Virology, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan.
Hitoshi
H
Oshitani
Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8523, Japan.|Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.
Koya
K
Ariyoshi
Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8523, Japan.|Department of Pediatrics, Nagasaki University Hospital, Nagasaki, 852-8102, Japan.
Hiroyuki
H
Moriuchi
Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.|Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8523, Japan.
Masahiro
M
Hashizume
National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
Duc Anh
DA
Dang
Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, 852-8523, Japan.
Lay-Myint
LM
Yoshida
D002675:Child, Preschool; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D060885:Multiplex Polymerase Chain Reaction / Q000379:methods; D011024:Pneumonia, Viral / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology / Q000235:genetics; D018113:Respiratory Syncytial Virus, Human / Q000235:genetics*; D014744:Vietnam / Q000453:epidemiology