Suppression of ectopic assembly of centriole proteins ensures mitotic spindle integrity.
Abnormalities in maintaining the appropriate number of centrioles could be the origin of genome instability in tumor formation. Recently, we demonstrated that ectopic formation of aberrant centriole-related structures occurs even in the presence of pre-existing centrioles, leading to mitotic spindle defects and possibly contributing to tumorigenesis.
Centrosome Biology Laboratory; Center for Frontier Research; National Institute of Genetics ; Mishima, Shizuoka, Japan.
Gen
G
Shiratsuchi
Centrosome Biology Laboratory; Center for Frontier Research; National Institute of Genetics ; Mishima, Shizuoka, Japan.
Daiju
D
Kitagawa
cartwheel; centriole; centrosome; chromosome segregation; genome integrity