Safety and effectiveness of combined antihypertensive and cholesterol-lowering therapy in high-/very high-risk patients.
Controlling cardiovascular (CV) risk factors is paramount in reducing atherosclerotic events. This 6-month prospective noninterventional trial assessed the safety and effectiveness of fixed-combination lisinopril-amlodipine plus rosuvastatin.



Patients with mild/moderate hypertension and hypercholesterolemia, at high-/very high-CV risk, received lisinopril-amlodipine (10/5, 20/5 or 20/10 mg/day) plus rosuvastatin (10 or 20 mg/day). Primary end points: systolic/diastolic blood pressure, low-density lipoprotein cholesterol.



At 6 months, 91% of 2241 evaluable patients achieved blood pressure target (<140/90 mmHg); low-density lipoprotein cholesterol targets, <3, <2.5 and 1.8 mmol/l, were achieved by 67, 49 and 40% of patients, respectively. Adverse events (4.4%) were mostly mild.



Lisinopril-amlodipine plus rosuvastatin was well tolerated and effective in patients with mild/moderate hypertension and hypercholesterolemia at high/very high CV risk.
Coromed Kft., Cardiology private practice, Pécs, Hungary.
Attila
A
Kónyi
Coromed Kft., Cardiology private practice, Pécs, Hungary.
Zsolt
Z
Sárszegi
Department of Biophysics, Faculty of Medicine, University of Pécs, Pécs, Hungary.
Gábor
G
Hild
Coromed Kft., Cardiology private practice, Pécs, Hungary.
Balázs
B
Gaszner
D017311:Amlodipine; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002784:Cholesterol; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D006973:Hypertension / Q000188:drug therapy*; D011446:Prospective Studies
D000924:Anticholesteremic Agents; D000959:Antihypertensive Agents; D017311:Amlodipine; D002784:Cholesterol
cardiovascular risk; diabetes mellitus; hypercholesterolemia; hypertension; lisinopril–amlodipine; rosuvastatin