Moving ahead on harnessing synthetic lethality to fight cancer.
We have recently developed a data-mining pipeline that comprehensively identifies cancer unique susceptibilities, following the concept of Synthetic Lethality (SL). The approach enables, for the first time, to identify and harness genome-scale SL-networks to accurately predict gene essentiality, drug response, and clinical prognosis in cancer.
The Blavatnik School of Computer Science; Tel Aviv University ; Tel Aviv , Israel.
Livnat
L
Jerby-Arnon
The Blavatnik School of Computer Science; Tel Aviv University; Tel Aviv, Israel; The Sackler School of Medicine; Tel Aviv University; Tel Aviv, Israel.
Eytan
E
Ruppin
cancer genomics; genetic interactions; precision medicine; synthetic lethality