Anti-HIV microRNA expression in a novel Indian cohort.
HIV-1 replication inside host cells is known to be regulated by various host factors. Host miRNAs, by virtue of its normal functioning, also regulate HIV-1 RNA expression by either directly targeting virus mRNAs or indirectly by regulating host proteins that HIV-1 uses for own replication. Therefore, it is highly possible that with differential miRNA expression, rate of disease progression will vary in HIV-1 infected individuals. In this study we have compared expression of a panel of 13 reported anti-HIV miRNAs in human PBMCs from long term non progressors (LTNPs), regular progressors and rapid progressors. We found that LTNPs have substantial lower expression of miR-382-5p that positively correlates with viral loads. Combinatorial regulation is highly probable in dictating differential disease progression as average expression of miR-382-5p and miR-155-5p can substantially distinguish LTNP individuals from regular progressors.
CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110 020, India.|Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
Rakesh
R
Dey
CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110 020, India.
Kartik
K
Soni
Y R Gaitonde Centre for AIDS Research and Education (YRG CARE), VHS Campus, Rajiv Gandhi Road, Taramani, Chennai 600113, India.
Shanmugam
S
Saravanan
Y R Gaitonde Centre for AIDS Research and Education (YRG CARE), VHS Campus, Rajiv Gandhi Road, Taramani, Chennai 600113, India.
Pachamuthu
P
Balakrishnan
CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110 020, India.
Vikram
V
Kumar
Y R Gaitonde Centre for AIDS Research and Education (YRG CARE), VHS Campus, Rajiv Gandhi Road, Taramani, Chennai 600113, India.
Jayaseelan
J
Boobalan
Y R Gaitonde Centre for AIDS Research and Education (YRG CARE), VHS Campus, Rajiv Gandhi Road, Taramani, Chennai 600113, India.|Johns Hopkins University School of Medicine, Baltimore, USA.
Sunil Suhas
SS
Solomon
CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110 020, India.|Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
Vinod
V
Scaria
Y R Gaitonde Centre for AIDS Research and Education (YRG CARE), VHS Campus, Rajiv Gandhi Road, Taramani, Chennai 600113, India.
Suniti
S
Solomon
CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110 020, India.|Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
Samir K
SK
Brahmachari
CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110 020, India.|Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
Beena
B
Pillai
D000293:Adolescent; D000328:Adult; D005260:Female; D015658:HIV Infections / Q000378:metabolism* / Q000473:pathology; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007194:India; D007963:Leukocytes, Mononuclear / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis*; D008875:Middle Aged; D014779:Virus Replication / Q000502:physiology*
C524942:MIRN155 microRNA, human; C555413:MIRN382 microRNA, human; D035683:MicroRNAs