Cytotoxic phenylpropanoid glycosides from Cirsium japonicum.
Three new phenylpropanoid glycosides 1-3, along with nine known phenylpropanoid glycosides 4-12, were isolated from the aerial parts of Cirsium japonicum. The structures of isolated compounds were elucidated by chemical and spectroscopic methods. Compounds 1, 3, 6, 8, and 11 showed moderate cytotoxicities against MCF-7, U87, HCT116, and A549 cell lines with IC50values in the range of 1.35-11.32 μM. The known compounds 4-12 were obtained from this plant for the first time.
a Department of Cardiology , Nanyang the First People's Hospital , Nanyang 473002 , China.
Dong-Li
DL
Shang
b College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang 473061 , China.
Qin-Ge
QG
Ma
c College of Pharmacy , China Pharmaceutical University , Nanjing 210009 , China.
Rong-Rui
RR
Wei
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031180:Cirsium / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045325:HCT116 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D035261:Plant Components, Aerial / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D010666:Phenylpropionates
Cirsium japonicum; Compositae; cytotoxic activity; phenylpropanoid glycoside