Repeated fecal microbiota transplantation in a child with ulcerative colitis.
We report the case of an 11-year-old girl with ulcerative colitis refractory to conventional therapy, who was subsequently treated successfully with repeated fecal microbiota transplantation (FMT). The patient was steroid dependent despite several infliximab treatments, and colectomy was proposed to improve quality of life. After repeated FMT, she was able to maintain remission with on minimal dose of steroid. Although her fecal microbiota was dysbiotic before FMT, it was restored to a similar pattern as the donor after repeated FMT.
Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.
Hirotaka
H
Shimizu
Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.
Katsuhiro
K
Arai
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Jun
J
Abe
Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan.
Kazuhiko
K
Nakabayashi
Department of Pathology, National Center for Child Health and Development, Tokyo, Japan.
Takako
T
Yoshioka
Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.
Kenji
K
Hosoi
Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan.
Makoto
M
Kuroda
D002648:Child; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D003113:Colonoscopy; D000069467:Fecal Microbiota Transplantation / Q000379:methods*; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D012074:Remission Induction
child; fecal microbiota transplantation; inflammatory bowel disease; pediatric; ulcerative colitis