Could Killing Bacterial Subpopulations Hit Tuberculosis out of the Park?
One hurdle to treating tuberculosis could be that it is so difficult to kill nonreplicating subpopulations of the causative pathogens. This work describes two new cephalosporin derivatives that specifically target this population of Mycobacterium tuberculosis.
Department of Immunology and Infectious Disease, Harvard T. H. Chan School of Public Health , Boston, Massachusetts 02115, United States.
Catherine
C
Baranowski
Department of Immunology and Infectious Disease, Harvard T. H. Chan School of Public Health , Boston, Massachusetts 02115, United States.|Department of Microbiology and Immunobiology, Harvard Medical School , Boston, Massachusetts 02115, United States.
Eric J
EJ
Rubin
D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D055808:Drug Discovery; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000502:physiology; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology
D000995:Antitubercular Agents