Association of catechol-O-methyltransferase Val(108/158) Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population.
Catechol-O-methyltransferase (COMT), an enzyme involved in the degradation and inactivation of the neurotransmitter dopamine, is associated with the sensory gating phenomenon, protecting the cerebral cortex from information overload. The COMT Val(108/158)Met polymorphism is essential for prefrontal cortex processing capacity and efficiency. The current study was designed to investigate the role of COMT Val(108/158)Met polymorphism in development, sensory gating deficit, and symptoms of schizophrenia in Han Chinese population. P50 gating was determined in 139 schizophrenic patients and 165 healthy controls. Positive and Negative Syndrome Scale (PANSS) was used to assess the clinical symptomatology in 370 schizophrenic subjects. COMT Val(108/158)Met polymorphism was genotyped by PCR-restriction fragment length polymorphism (PCR-RFLP). No significant differences in COMT allele and genotype distributions were observed between schizophrenic patients and control groups. Although P50 deficits were present in patients, there was no evidence for an association between COMT Val(108/158)Met polymorphism and the P50 biomarker. Moreover, PANSS negative subscore was significantly higher in Val allele carriers than in Met/Met individuals. The present findings suggest that COMT Val(108/158)Met polymorphism may not contribute to the risk of schizophrenia and to the P50 deficits, but may contribute to the negative symptoms of schizophrenia among Han Chinese.
Biological Psychiatry Research Center, Peking University Huilongguan Teaching Hospital, Beijing 100096, PR China.
Qiao
Q
Mao
Biological Psychiatry Research Center, Peking University Huilongguan Teaching Hospital, Beijing 100096, PR China. Electronic address: yltan21@126.com.
Yun-Long
YL
Tan
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Xing-Guang
XG
Luo
Neuroscience Center, University of Helsinki, Viikinkaari 4, FIN-00014 Helsinki, Finland.
Li
L
Tian
Biological Psychiatry Research Center, Peking University Huilongguan Teaching Hospital, Beijing 100096, PR China.
Zhi-Ren
ZR
Wang
Biological Psychiatry Research Center, Peking University Huilongguan Teaching Hospital, Beijing 100096, PR China.
Shu-Ping
SP
Tan
Biological Psychiatry Research Center, Peking University Huilongguan Teaching Hospital, Beijing 100096, PR China.
Song
S
Chen
Biological Psychiatry Research Center, Peking University Huilongguan Teaching Hospital, Beijing 100096, PR China.
Gui-Gang
GG
Yang
Biological Psychiatry Research Center, Peking University Huilongguan Teaching Hospital, Beijing 100096, PR China.
Hui-Mei
HM
An
Biological Psychiatry Research Center, Peking University Huilongguan Teaching Hospital, Beijing 100096, PR China.
Fu-De
FD
Yang
Biological Psychiatry Research Center, Peking University Huilongguan Teaching Hospital, Beijing 100096, PR China; Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Xiang-Yang
XY
Zhang
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000378:metabolism; D002681:China; D004298:Dopamine / Q000378:metabolism; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017397:Prefrontal Cortex / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D055139:Sensory Gating / Q000235:genetics*
C588010:COMT protein, human; D002394:Catechol O-Methyltransferase; D004298:Dopamine
Biomarker; COMT; Negative symptom; Schizophrenia; Sensory gating