Growth and Development in Extremely Low Birth Weight Infants After the Introduction of Exclusive Human Milk Feedings.
ObjectiveTo estimate associations of exclusive human milk (EHM) feedings with growth and neurodevelopment through 18 months corrected age (CA) in extremely low birth weight (ELBW) infants.Study DesignELBW infants admitted from July 2011 to June 2013 who survived were reviewed. Infants managed from July 2011 to June 2012 were fed with bovine milk-based fortifiers and formula (BOV). Beginning in July 2012, initial feedings used a human milk-based fortifier to provide EHM feedings. Infants were grouped on the basis of feeding regimen. Primary outcomes were the Bayley-III cognitive scores at 6, 12, and 18 months and growth.ResultsInfants (n= 85; 46% received EHM) were born at 26 ± 1.9 weeks (p= 0.92 between groups) weighing 776 ± 139 g (p= 0.67 between groups). Cognitive domain scores were similar at 6 months (BOV: 96 ± 7; EHM: 95 ± 14;p= 0.70), 12 months (BOV: 97 ± 10; EHM: 98 ± 9;p= 0.86), and 18 months (BOV: 97 ± 16; EHM: 98 ± 14;p= 0.71) CA. Growth velocity prior to discharge (BOV: 12.1 ± 5.2 g/kg/day; EHM: 13.1 ± 4.0 g/kg/day;p= 0.33) and subsequent growth was similar between groups.ConclusionEHM feedings appear to support similar growth and neurodevelopment in ELBW infants as compared with feedings containing primarily bovine milk-based products.
Division of Neonatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Michael
M
Colacci
Division of Neonatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Karna
K
Murthy
Division of Neonatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Raye-Ann O
RO
DeRegnier
Division of Neonatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Janine Y
JY
Khan
Division of Neonatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Daniel T
DT
Robinson
D000818:Animals; D001724:Birth Weight; D003071:Cognition; D005527:Food, Fortified; D005865:Gestational Age; D006801:Humans; D007223:Infant; D041943:Infant Formula; D052577:Infant, Extremely Low Birth Weight / Q000254:growth & development*; D007231:Infant, Newborn; D007804:Language Development; D008892:Milk; D008895:Milk, Human; D009048:Motor Skills; D009483:Neuropsychological Tests