Drosophila Aurora A regulates mitotic timing in cancer stem cells: Possible therapeutic implications.
Loss of Aurora A in Drosophila neuroblasts promotes loss of cell fate, leading to brain tumors. We showed that these tumor stem cells are delayed during mitosis and efficiently segregate their chromosomes even without the spindle assembly checkpoint. Here, we discuss the possible relevance of our results to human cancers.
Institut de Génétique et Développement de Rennes-Université de Rennes I-CNRS- UMR 6290 , Rennes Cedex, France.
Renaud
R
Caous
Institut de Génétique et Développement de Rennes-Université de Rennes I-CNRS- UMR 6290 , Rennes Cedex, France.
Laurent
L
Richard-Parpaillon
Institut de Génétique et Développement de Rennes-Université de Rennes I-CNRS- UMR 6290 , Rennes Cedex, France.
Régis
R
Giet
Aneuploidy; Aurora A kinase; Spindle Assembly Checkpoint; stem cell; tumour