PRKD2: A two-pronged kinase crucial for the tumor-supporting activity of HSP90.
PRKD2 plays an important role in tumor cell survival, proliferation, migration, and angiogenesis. We recently reported that cell death and impaired blood vessel formation evoked by inhibition of the HSP90 chaperone in human cancer cells of various tissue origins is mediated by destabilization of PRKD2.
Center for Internal Medicine I; Ulm University Hospital ; Ulm, Germany.
Ninel
N
Azoitei
Department of Translational Oncology; National Center for Tumor Diseases and German Cancer Research Center ; Heidelberg, Germany.
Stefan
S
Fröhling
Department of Translational Oncology; National Center for Tumor Diseases and German Cancer Research Center ; Heidelberg, Germany.
Claudia
C
Scholl
Center for Internal Medicine I; Ulm University Hospital ; Ulm, Germany.
Thomas
T
Seufferlein
Protein kinase D2; heat shock protein 90 (HSP90) chaperone; hypoxia; nuclear factor kappa B (NF-kB); tumor angiogenesis