Pelargonidin Improves Passive Avoidance Task Performance in a Rat Amyloid Beta25-35 Model of Alzheimer's Disease Via Estrogen Receptor Independent Pathways.
Alzheimer's disease (AD) is a disorder with multiple pathophysiological causes, destructive outcomes, and no available definitive cure. Pelargonidin (Pel), an anthocyanin derivative, is an estrogen receptor agonist with little estrogen side effects. This study was designed to assess Pel memory enhancing effects on the a rat Amyloid Beta25-35 (Aβ) intrahippocampal microinjections model of AD in the passive avoidance task performance paradigm and further evaluate the potential estrogen receptor role on the memory-evoking compound. Equally divided rats were assigned to 5 groups of sham, Aβ intrahippocampal microinjected, Pel pretreated (10 mg/kg; P.O), α estrogen antagonist intra-cerebrovascular (i.c.v.) microinjected, and β estrogen antagonist (i.c.v) microinjected animals. Intrahippocampal microinjections of Aβ were adopted to provoke AD model. Passive avoidance task test was also used to assess memory performance. Pel pretreatment prior to Aβ microinjections significantly improved step-through latency (P<0.001) in passive avoidance test. In α and β estrogen, antagonists received animals, passive avoidance task performance was not statistically changed (P=0.11 & P=0.41 respectively) compared to Pel pretreated and sham animals. Our results depicted that Pel improves Aβ induced memory dysfunction in passive avoidance test performance through estrogen receptor independently related pathways.
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Hamid
H
Sohanaki
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Tourandokht
T
Baluchnejadmojarad
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Farnaz
F
Nikbakht
Neurophysiology Research Center, Shahed University, Tehran, Iran.
Mehrdad
M
Roghani
D000544:Alzheimer Disease / Q000188:drug therapy*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D004195:Disease Models, Animal; D006624:Hippocampus / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011960:Receptors, Estrogen / Q000378:metabolism; D013647:Task Performance and Analysis
D016229:Amyloid beta-Peptides; D000872:Anthocyanins; D011960:Receptors, Estrogen; C066957:pelargonidin
Alzheimer’s disease; Estrogen receptor; Hippocampus; Memory dysfunction; Passive avoidance test; Pelargonidin