Using Literature-Based Discovery to Explain Adverse Drug Effects.
We report on our research in using literature-based discovery (LBD) to provide pharmacological and/or pharmacogenomic explanations for reported adverse drug effects. The goal of LBD is to generate novel and potentially useful hypotheses by analyzing the scientific literature and optionally some additional resources. Our assumption is that drugs have effects on some genes or proteins and that these genes or proteins are associated with the observed adverse effects. Therefore, by using LBD we try to find genes or proteins that link the drugs with the reported adverse effects. These genes or proteins can be used to provide insight into the processes causing the adverse effects. Initial results show that our method has the potential to assist in explaining reported adverse drug effects.
Institute for Biostatistics and Medical Informatics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. dimitar.hristovski@mf.uni-lj.si.
Dimitar
D
Hristovski
Faculty of Information Studies, Novo mesto, Ljubljana, Slovenia.
Andrej
A
Kastrin
Faculty of Medicine, University of Maribor, Maribor, Slovenia.
Dejan
D
Dinevski
INSERM UMRS 1138 Eq 22, Paris Descartes University, Georges Pompidou European Hospital, APHP, Paris, France.
Anita
A
Burgun
Institute of Pharmacology and Experimental Toxicology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Lovro
L
Žiberna
National Library of Medicine, NIH, Bethesda, USA.
Thomas C
TC
Rindflesch
D057225:Data Mining / Q000379:methods*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods*; D060735:Pharmacovigilance
Adverse drug effects; Adverse drug reactions; Literature-based discovery; Pharmacogenomics; Pharmacovigilance; Text mining