Reproducibility of Gadolinium Enhancement Patterns and Wall Thickness in Hypertrophic Cardiomyopathy.
BACKGROUND
Reproducibility data of the extent and patterns of late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) is limited.


OBJECTIVE
To explore the reproducibility of regional wall thickness (WT), LGE extent, and LGE patterns in patients with HCM assessed with cardiac magnetic resonance (CMR).


METHODS
The extent of LGE was assessed by the number of segments with LGE, and by the total LV mass with LGE (% LGE); and the pattern of LGE-CMR was defined for each segment.


RESULTS
A total of 42 patients (672 segments) with HCM constituted the study population. The mean WT measurements showed a mean difference between observers of -0.62 ± 1.0 mm (6.1%), with limits of agreement of 1.36 mm; -2.60 mm and intraclass correlation coefficient (ICC) of 0.95 (95% CI 0.93-0.96). Maximum WT measurements showed a mean difference between observers of -0.19 ± 0.8 mm (0.9%), with limits of agreement of 1.32 mm; -1.70 mm, and an ICC of 0.95 (95% CI 0.91-0.98). The % LGE showed a mean difference between observers of -1.17 ± 1.2 % (21%), with limits of agreement of 1.16%; -3.49%, and an ICC of 0.94 (95% CI 0.88-0.97). The mean difference between observers regarding the number of segments with LGE was -0.40 ± 0.45 segments (11%), with limits of agreement of 0.50 segments; -1.31 segments, and an ICC of 0.97 (95% CI 0.94-0.99).


CONCLUSIONS
The number of segments with LGE might be more reproducible than the percent of the LV mass with LGE.
Department of Cardiovascular Imaging, Diagnóstico Maipú, Buenos Aires, Argentina.
Gaston A
GA
Rodriguez-Granillo
Department of Cardiovascular Imaging, Diagnóstico Maipú, Buenos Aires, Argentina.
Alejandro
A
Deviggiano
Department of Cardiovascular Imaging, Diagnóstico Maipú, Buenos Aires, Argentina.
Carlos
C
Capunay
Department of Cardiovascular Imaging, Diagnóstico Maipú, Buenos Aires, Argentina.
Macarena C De
MC
Zan
Department of Cardiovascular Imaging, Diagnóstico Maipú, Buenos Aires, Argentina.
Patricia
P
Carrascosa
D000328:Adult; D000368:Aged; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging*; D005260:Female; D005682:Gadolinium; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011856:Radiographic Image Enhancement / Q000379:methods*; D012016:Reference Values; D015203:Reproducibility of Results; D018570:Risk Assessment; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging
D005682:Gadolinium