Sliding Hydrogels with Mobile Molecular Ligands and Crosslinks as 3D Stem Cell Niche.
The development of a sliding hydrogel with mobile crosslinks and biochemical ligands as a 3D stem cell niche is reported. The molecular mobility of this sliding hydrogel allows stem cells to reorganize the surrounding ligands and change their morphology in 3D. Without changing matrix stiffness, sliding hydrogels support efficient stem cell differentiation toward multiple lineages including adipogenesis, chondrogenesis, and osteogenesis.
Department of Orthopaedic Surgery, Stanford University School of Medicine, CA, 94305, USA.
Xinming
X
Tong
Departments of Orthopaedic Surgery and Bioengineering, Stanford University School of Medicine, 300 Pasteur Dr, Edwards R105, CA, 94305, USA.
Fan
F
Yang
D050156:Adipogenesis; D020219:Chondrogenesis; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008024:Ligands; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D010012:Osteogenesis; D055153:Stem Cell Niche
D003432:Cross-Linking Reagents; D020100:Hydrogels; D008024:Ligands
cell niches; cyclodextrins; sliding hydrogels