Comparative Study of EPA-enriched Phosphatidylcholine and EPA-enriched Phosphatidylserine on Lipid Metabolism in Mice.
Recent studies have shown that EPA enriched PLs have beneficial effects on lipid metabolism. Our previous study has demonstrated that the anti-obesity and hypolipidemic effects of EPA-PL were superior to DHA-PL. In the present study, we comparatively evaluated the effects of EPA-enriched phosphatidylcholine (EPA-PC) and EPA-enriched phosphatidylserine (EPA-PS) on lipid metabolism in mice. Both 2% dietary EPA-PC and EPA-PS significantly improved serum and hepatic lipid levels in mice. The HDL-c level in mice on EPA-PC diet was significantly higher than the other two groups. The level of DHA in hepatic TG and PL were significantly increased in both EPA-PC and EPA-PS fed groups (98.3 and 117.8%, respectively; p < 0.05). Notably, the proportion of DHA in EPA-PS group was significantly higher than the EPA-PC group. EPA-PC and EPA-PS suppressed hepatic SREBP-1c mediated lipogenesis and activated PPARα mediated fatty acid β-oxidation in the liver. These data are the first to indicate that EPA-PS has beneficial effects on lipid metabolism.
College of Food Science and Engineering, Ocean University of China.
Lin
L
Ding
Dan
D
Wang
Miaomiao
M
Zhou
Lei
L
Du
Jie
J
Xu
Changhu
C
Xue
Yuming
Y
Wang
D000818:Animals; D015118:Eicosapentaenoic Acid / Q000737:chemistry*; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010713:Phosphatidylcholines / Q000737:chemistry / Q000494:pharmacology*; D010718:Phosphatidylserines / Q000737:chemistry / Q000494:pharmacology*
D008055:Lipids; D010713:Phosphatidylcholines; D010718:Phosphatidylserines; D015118:Eicosapentaenoic Acid