The Hippo-YAP/TAZ pathway mediates geranylgeranylation signaling in breast cancer progression.
Protein geranylgeranylation (GGylation) regulates the function of various signal transducers including small GTPases and Ggamma subunits. The role of GGylation in breast cancer progression is poorly understood. Recent studies suggest that GGylation promotes the proliferation and migration of breast carcinoma cells through the Hippo-YAP/TAZ pathway.
School of Medical Sciences & Laboratory Medicine, Jiangsu University, Zhenjiang, China; Weis Center for Research, Geisinger Clinic, Danville, PA, USA.
Qiong
Q
Lin
Weis Center for Research, Geisinger Clinic , Danville, PA, USA.
Wannian
W
Yang
Breast cancer; TAZ; YAP; geranylgeranylation; the Hippo pathway