Joint feature-sample selection and robust diagnosis of Parkinson's disease from MRI data.
Parkinson's disease (PD) is an overwhelming neurodegenerative disorder caused by deterioration of a neurotransmitter, known as dopamine. Lack of this chemical messenger impairs several brain regions and yields various motor and non-motor symptoms. Incidence of PD is predicted to double in the next two decades, which urges more research to focus on its early diagnosis and treatment. In this paper, we propose an approach to diagnose PD using magnetic resonance imaging (MRI) data. Specifically, we first introduce a joint feature-sample selection (JFSS) method for selecting an optimal subset of samples and features, to learn a reliable diagnosis model. The proposed JFSS model effectively discards poor samples and irrelevant features. As a result, the selected features play an important role in PD characterization, which will help identify the most relevant and critical imaging biomarkers for PD. Then, a robust classification framework is proposed to simultaneously de-noise the selected subset of features and samples, and learn a classification model. Our model can also de-noise testing samples based on the cleaned training data. Unlike many previous works that perform de-noising in an unsupervised manner, we perform supervised de-noising for both training and testing data, thus boosting the diagnostic accuracy. Experimental results on both synthetic and publicly available PD datasets show promising results. To evaluate the proposed method, we use the popular Parkinson's progression markers initiative (PPMI) database. Our results indicate that the proposed method can differentiate between PD and normal control (NC), and outperforms the competing methods by a relatively large margin. It is noteworthy to mention that our proposed framework can also be used for diagnosis of other brain disorders. To show this, we have also conducted experiments on the widely-used ADNI database. The obtained results indicate that our proposed method can identify the imaging biomarkers and diagnose the disease with favorable accuracies compared to the baseline methods.
Department of Radiology and BRIC, University of North Carolina-Chapel Hill, NC 27599, USA.
Ehsan
E
Adeli
Department of Radiology and BRIC, University of North Carolina-Chapel Hill, NC 27599, USA.
Feng
F
Shi
Department of Radiology and BRIC, University of North Carolina-Chapel Hill, NC 27599, USA.
Le
L
An
Department of Radiology and BRIC, University of North Carolina-Chapel Hill, NC 27599, USA; Department of Biomedical Engineering, National University of Singapore, Singapore.
Chong-Yaw
CY
Wee
Department of Radiology and BRIC, University of North Carolina-Chapel Hill, NC 27599, USA.
Guorong
G
Wu
Department of Radiology and BRIC, University of North Carolina-Chapel Hill, NC 27599, USA; Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Alzheimer's Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, China.
Tao
T
Wang
Department of Radiology and BRIC, University of North Carolina-Chapel Hill, NC 27599, USA; Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea. Electronic address: dgshen@med.unc.edu.
Dinggang
D
Shen
D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D010363:Pattern Recognition, Automated / Q000379:methods*; D012680:Sensitivity and Specificity; D000069558:Unsupervised Machine Learning
Diagnosis; Joint feature-sample selection; Matrix completion; Parkinson's disease; Robust linear discriminant analysis; Sparse regression