Counteracting oxidative phosphorylation-mediated resistance of melanomas to MAPK pathway inhibition.
Mitochondrial oxidative phosphorylation (OxPhos) induces resistance to MAPK pathway inhibitors in melanoma. However, therapeutic targeting of mitochondria is challenging. In a recent study, we showed that inhibition of mTOR kinase activity resensitized resistant melanomas by indirectly inhibiting OxPhos via a novel mechanism. Here, we discuss the implications of these findings.
Divison of Cancer Medicine and The University of Texas M.D. Anderson Cancer Center ; Houston, TX, USA.
Jennifer L
JL
McQuade
Department of Melanoma Medical Oncology; The University of Texas M.D. Anderson Cancer Center ; Houston, TX, USA.
Yn
Y
Vashisht Gopal
BRAF; MEK; MITF; NRAS; PGC1α; metabolism