A new C20-diterpenoid alkaloid from Aconitum soongaricum var. pubescens.
A new denudatine-type C20-diterpenoid alkaloid, pubesine (1), along with seven known diterpenoid alkaloids, altaconitine (2), 14-benzoylaconine (3), spicatine A (4), 14-benzoylaconine-8-palmitate (5), 14-O-acetylsenbusine A (6), senbusine A (7) and 14-acetylneoline (8) were isolated from the whole plant of Aconitum soongaricum var. pubescens. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and HR-ESI-MS) and comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against H460, MCF-7 and Hep G2 human cancer cell lines.
a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.|b Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering , Southwest Jiaotong University , Chengdu , China.|c School of Chemistry and Chemical Engineering , China West Normal University , Nanchong , China.
Lin
L
Chen
a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.
Lianhai
L
Shan
a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.
Wenliang
W
Xu
a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.
Jifa
J
Zhang
a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.
Shuai
S
Huang
a School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.|b Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering , Southwest Jiaotong University , Chengdu , China.
Xianli
X
Zhou
D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes
Aconitum soongaricum var. pubescens; Diterpenoid alkaloid; cytotoxic activity; pubesine