The BARD1/HP1 interaction: Another clue to heterochromatin involvement in homologous recombination.
Chromatin compaction represents a barrier for the repair of DNA double-strand breaks (DSBs). However, heterochromatin components are also required for DSB repair by homologous recombination. The BARD1/HP1 interaction, required for the retention of BRCA1, CTIP, and RAD51 at DSB sites, may play a critical role in the crosstalk between chromatin compaction and DSB repair.
Department of Translational Oncology; St. Marianna University Graduate School of Medicine ; Kawasaki, Japan.
Takayo
T
Fukuda
Department of Translational Oncology; St. Marianna University Graduate School of Medicine ; Kawasaki, Japan.
Tomoko
T
Tsuruga
Department of Translational Oncology; St. Marianna University Graduate School of Medicine ; Kawasaki, Japan.
Takako
T
Kuroda
Department of Translational Oncology; St. Marianna University Graduate School of Medicine ; Kawasaki, Japan.
Jun
J
Takeuchi
Department of Translational Oncology; St. Marianna University Graduate School of Medicine ; Kawasaki, Japan.
Wenwen
W
Wu
Department of Translational Oncology; St. Marianna University Graduate School of Medicine ; Kawasaki, Japan.
Tomohiko
T
Ohta
BARD1; BRCA1; H3K9me2; HP1; heterochromatin; homologous recombination