Maternal serum Netrin-1 levels as a new biomarker of preeclampsia.
OBJECTIVE
The aim of this study was to investigate whether the Netrin-1 levels in maternal serum was associated with the presence of preeclampsia (PE).


METHODS
Total 72 patients, including 28 normal pregnant women and 44 patients with PE, were included in this study. Maternal serum Netrin-1 concentration was measured by enzyme-linked immunosorbent assay (ELISA).


RESULTS
Maternal serum Netrin-1 levels were detected statistically higher in preeclamptic group than control group (p < 0.05). When compared with subgroups, Netrin-1 levels were also higher in severe PE group than mild PE group but this was not detected statistically significant (p > 0.05).


CONCLUSIONS
Maternal serum Netrin-1 has a potential to be a new marker for the detection of PE.
a Department of Obstetrics and Gyneacology , Health Sciences University Umraniye Medical and Research Hospital , İstanbul , Turkey.
Yasemin
Y
Çekmez
b Department of Biochemistry , Kemerburgaz Unıversity , İstanbul , Turkey , and.
Şebnem
Ş
Garip
a Department of Obstetrics and Gyneacology , Health Sciences University Umraniye Medical and Research Hospital , İstanbul , Turkey.
İpek
İ
Ulu
a Department of Obstetrics and Gyneacology , Health Sciences University Umraniye Medical and Research Hospital , İstanbul , Turkey.
Serdar
S
Gülşen
a Department of Obstetrics and Gyneacology , Health Sciences University Umraniye Medical and Research Hospital , İstanbul , Turkey.
Esra Tuştaş
ET
Haberal
c Department of Obstetrics and Gyneacology , Florence Nightingale Hospital , İstanbul , Turkey.
Yusuf
Y
Olgac
a Department of Obstetrics and Gyneacology , Health Sciences University Umraniye Medical and Research Hospital , İstanbul , Turkey.
Eser Evrim
EE
Yoğurtçuoğlu
a Department of Obstetrics and Gyneacology , Health Sciences University Umraniye Medical and Research Hospital , İstanbul , Turkey.
Simge Bagcı
SB
Türkmen
b Department of Biochemistry , Kemerburgaz Unıversity , İstanbul , Turkey , and.
Fatma Tutku
FT
Aksoy
a Department of Obstetrics and Gyneacology , Health Sciences University Umraniye Medical and Research Hospital , İstanbul , Turkey.
Gürkan
G
Kıran
D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D000075388:Netrin-1 / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011795:Surveys and Questionnaires
D015415:Biomarkers; D000075388:Netrin-1
Netrin-1; placenta; preeclampsia; vasculogenesis