Systemic Delivery and Biodistribution of Cisplatin in Vivo.
Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin's off-target effects, a new drug-fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.
Department of Chemistry, Portland State University , Portland, Oregon 97201, United States.
Yu-Hsuan
YH
Chu
Department of Chemistry, Portland State University , Portland, Oregon 97201, United States.
Martha
M
Sibrian-Vazquez
Department of Chemistry, Portland State University , Portland, Oregon 97201, United States.
Jorge O
JO
Escobedo
Amanda R
AR
Phillips
D Thomas
DT
Dickey
Qi
Q
Wang
Martina
M
Ralle
Peter S
PS
Steyger
Department of Chemistry, Portland State University , Portland, Oregon 97201, United States.
Robert M
RM
Strongin
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D002945:Cisplatin
Texas Red; cisplatin; conjugate; ototoxicity; tracer