Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma.
Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis.
Department of Biology; University of Rome 'Tor Vergata' ; Rome, Italy.
Paola
P
Giglio
Department of Biological and Environmental Science and Technology (Di.S.Te.B.A.); University of Salento; Lecce, Italy; National Institute for Infectious Diseases IRCCS'L. Spallanzani'; Rome, Italy.
Gian Maria
GM
Fimia
Dermatological Sciences Institute of Cellular Medicine; Newcastle University ; Newcastle upon Tyne, UK.
Penny E
PE
Lovat
Department of Biology; University of Rome 'Tor Vergata'; Rome, Italy; National Institute for Infectious Diseases IRCCS'L. Spallanzani'; Rome, Italy.
Mauro
M
Piacentini
Department of Biology; University of Rome 'Tor Vergata'; Rome, Italy; National Institute for Infectious Diseases IRCCS'L. Spallanzani'; Rome, Italy.
Marco
M
Corazzari
BRAF; ER stress; autophagy; cancer; melanoma