Recent advance in the pharmacogenomics of human Solute Carrier Transporters (SLCs) in drug disposition.
Drug pharmacokinetics is influenced by the function of metabolising enzymes and influx/efflux transporters. Genetic variability of these genes is known to impact on clinical therapies. Solute Carrier Transporters (SLCs) are the primary influx transporters responsible for the cellular uptake of drug molecules, which consequently, impact on drug efficacy and toxicity. The Organic Anion Transporting Polypeptides (OATPs), Organic Anion Transporters (OATs) and Organic Cation Transporters (OCTs/OCTNs) are the most important SLCs involved in drug disposition. The information regarding the influence of SLC polymorphisms on drug pharmacokinetics is limited and remains a hot topic of pharmaceutical research. This review summarises the recent advance in the pharmacogenomics of SLCs with an emphasis on human OATPs, OATs and OCTs/OCTNs. Our current appreciation of the degree of variability in these transporters may contribute to better understanding the inter-patient variation of therapies and thus, guide the optimisation of clinical treatments.
Faculty of Pharmacy, University of Sydney, NSW 2006, Australia. Electronic address: fanfan.zhou@sydney.edu.au.
Fanfan
F
Zhou
Save Sight Institute, the University of Sydney, Sydney, NSW 2000, Australia.
Ling
L
Zhu
Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu Province, China.
Ke
K
Wang
Pharmacogenomics and Drug Development Group, Discipline of Pharmacology, School of Medical Sciences, The University of Sydney, NSW 2006, Australia.
Michael
M
Murray
D016503:Drug Delivery Systems; D006801:Humans; D027361:Organic Anion Transporters; D010597:Pharmacogenetics
D027361:Organic Anion Transporters
Drug pharmacokinetics; Organic anion transporters; Organic anion transporting polypeptides; Organic cation transporters; Pharmacogenomics; Solute Carrier Transporters