Mutation in West Nile Virus Structural Protein prM during Human Infection.
A mutation leading to substitution of a key amino acid in the prM protein of West Nile virus (WNV) occurred during persistent infection of an immunocompetent patient. WNV RNA persisted in the patient's urine and serum in the presence of low-level neutralizing antibodies. This case demonstrates active replication of WNV during persistent infection.
Yaniv
Y
Lustig
Robert S
RS
Lanciotti
Musa
M
Hindiyeh
Nathan
N
Keller
Ron
R
Milo
Shlomo
S
Mayan
Ella
E
Mendelson
D057134:Antibodies, Neutralizing / Q000097:blood / Q000276:immunology; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D019562:Viral Load; D015678:Viral Structural Proteins / Q000235:genetics*; D014901:West Nile Fever / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D014902:West Nile virus / Q000145:classification / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D000073336:Whole Genome Sequencing
D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral; D015678:Viral Structural Proteins
WNV; WNV mutation; West Nile virus; human infection; persistent infection; prM protein; viruses