Prevention of breast cancer by RANKL/RANK blockade.
Robust genetic evidence in mice and humans indicates that RANK signaling plays a major role in mammary carcinogenesis driven by BRCA1/BRCA2 mutations. These findings may inaugurate a new era of breast cancer prevention, changing the life of millions of women worldwide.
Gustave Roussy Cancer Campus, Villejuif, France.|INSERM, U1138, Paris, France.|Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.|Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France.|Université Pierre et Marie Curie/Paris VI, Paris, France.
Lorenzo
L
Galluzzi
Gustave Roussy Cancer Campus, Villejuif, France.|INSERM, U1138, Paris, France.|Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.|Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France.|Université Pierre et Marie Curie/Paris VI, Paris, France.
Aitziber
A
Buqué
INSERM, U1138, Paris, France.|Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.|Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France.|Université Pierre et Marie Curie/Paris VI, Paris, France.|Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France.|Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.|Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.
Guido
G
Kroemer
D000818:Animals; D001943:Breast Neoplasms; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D051379:Mice; D009154:Mutation; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000235:genetics; D015398:Signal Transduction
D053246:Receptor Activator of Nuclear Factor-kappa B