Oxygen-Generating Biomaterials: A New, Viable Paradigm for Tissue Engineering?
There have been many attempts to provide sufficient nutrients, especially oxygen, to engineered large tissues to overcome the effects of hypoxia or poor vascularization. Delivering sufficient oxygen to the transplanted cells is one of the most critical issues that affects cell survival and correct maturation of engineered tissues. An emerging approach is using 3D scaffolds made from oxygen-generating biomaterials to tackle transport limitations deep within the engineered tissues. This class of biomaterials has opened a new window for overcoming the challenges associated with ischemia occurring within large tissue constructs. This review critically assesses oxygen-generating reagents, the main approaches for developing oxygen-generating biomaterials, and their potential as 3D scaffolds for regenerative medicine in a clinical setting.
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Mazaher
M
Gholipourmalekabadi
Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Susan
S
Zhao
Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Benjamin S
BS
Harrison
Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran. Electronic address: mozafari.masoud@gmail.com.
Masoud
M
Mozafari
Centre of Nanotechnology and Regenerative Medicine, University College London Medical School, London, UK; NanoRegMed Ltd, The London Innovation BioScience Centre, London, UK. Electronic address: a.seifalian@gmail.com.
Alexander M
AM
Seifalian
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D051379:Mice; D010100:Oxygen / Q000737:chemistry / Q000378:metabolism; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods / Q000639:trends
D001672:Biocompatible Materials; D010100:Oxygen
biomaterial; hypoxia; oxygen generation; regeneration; stem cells; tissue engineering