ERBB2 oncogenicity: ERBIN helps to perform the job.
ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2) is an oncogenic tyrosine kinase receptor that is overexpressed in breast cancer. Antibodies and inhibitors targeting ERBB2 are currently available, although therapeutic failures remain frequent. We discuss here recent data showing that the scaffold protein ERBB2IP (ERBB2 interacting protein, best known as ERBIN) regulates ERBB2 stability and may represent a future therapeutic target.
Department of Neuroscience and Regenerative Medicine and Department of Neurology; Medical College of Georgia; Georgia Regents University ; Augusta, GA, USA.
Lin
L
Mei
Centre de Recherche en Cancérologie de Marseille; Cell Polarity, Cell Signaling and Cancer "Equipe labellisée Ligue Contre le Cancer" INSERM U1068; Marseille, France; Institut Paoli-Calmettes; Marseille, France; Aix-Marseille Université; Marseille, France; CNRS UMR7258; Marseille, France.
Jean-Paul
JP
Borg
ERBB2; Erbin; HER2; PDZ domain; breast cancer; protein stability