Actin Rings of Power.
Circular or ring-like actin structures play important roles in various developmental and physiological processes. Commonly, these rings are composed of actin filaments and myosin motors (actomyosin) that, upon activation, trigger ring constriction. Actomyosin ring constriction, in turn, has been implicated in key cellular processes ranging from cytokinesis to wound closure. Non-constricting actin ring-like structures also form at cell-cell contacts, where they exert a stabilizing function. Here, we review recent studies on the formation and function of actin ring-like structures in various morphogenetic processes, shedding light on how those different rings have been adapted to fulfill their specific roles.
Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.
Cornelia
C
Schwayer
Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.
Mateusz
M
Sikora
Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.
Jana
J
Slováková
Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.
Roland
R
Kardos
Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria. Electronic address: heisenberg@ist.ac.at.
Carl-Philipp
CP
Heisenberg
D008841:Actin Cytoskeleton; D000199:Actins / Q000378:metabolism*; D000818:Animals; D002448:Cell Adhesion; D048749:Cytokinesis; D006801:Humans; D014945:Wound Healing
D000199:Actins