Posaconazole Plasma Concentrations on Days Three to Five Predict Steady-State Levels.
Low posaconazole plasma concentrations (PPCs) have been associated with breakthrough invasive fungal infections. We assessed the correlation between pre-steady-state PPCs (obtained between days 3 and 5) and PPCs obtained during steady state in 48 patients with underlying hematological malignancies receiving posaconazole oral-solution prophylaxis. Pre-steady-state PPCs correlated significantly with PPCs obtained at steady state (Spearman r = 0.754; P < 0.001). Receiver operating characteristic (ROC) curve analysis of pre-steady-state PPCs revealed an area under the curve (AUC) of 0.884 (95% confidence interval [CI], 0.790 to 0.977) for predicting satisfactory PPCs at steady state.
Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria Center for Biomarker Research in Medicine, Graz, Austria.
Jürgen
J
Prattes
Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Wiebke
W
Duettmann
Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria Center for Biomarker Research in Medicine, Graz, Austria Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria Division of Infectious Diseases, Department of Medicine, University of California San Diego, San Diego, California, USA martin.hoenigl@medunigraz.at.
Martin
0000-0002-1653-2824
M
Hoenigl
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000097:blood* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D016903:Drug Monitoring; D005260:Female; D019337:Hematologic Neoplasms / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000097:blood / Q000188:drug therapy*; D012372:ROC Curve; D014230:Triazoles / Q000097:blood* / Q000493:pharmacokinetics* / Q000627:therapeutic use
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole