Chewing the fat for Akt1 inhibition and oncosuppression.
The catabolic and energy-dissipating actions of mitochondrial uncoupling proteins (UCPs) conflict with many of the bioenergetic hallmarks of malignancy. We have recently demonstrated that overexpression of mitochondrial uncoupling protein 3 (Ucp3) in the basal epidermis impedes skin tumorigenesis through a novel pathway of thymoma viral proto-oncogene 1 (Akt1) inhibition via increased mitochondrial lipid catabolism.
Department of Biochemistry, University of Utah School of Medicine , Salt Lake City, UT, USA.
Sara M
SM
Nowinski
Division of Pharmacology and Toxicology, College of Pharmacy and; Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USA.
Ashley
A
Solmonson
Division of Pharmacology and Toxicology, College of Pharmacy and; Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USA.
Edward M
EM
Mills
Akt; UCP3; keratinocytes; lipid catabolism; metabolomics; mitochondria; skin cancer; uncoupling; uncoupling proteins