Alternative end joining, clonal evolution, and escape from a telomere-driven crisis.
Telomere dysfunction and fusion play key roles in driving genomic instability and clonal evolution in many tumor types. We have recently described a role for DNA ligase III (LIG3) in facilitating the escape of cells from crisis induced by telomere dysfunction. Our data indicate that LIG3-mediated telomere fusion is important in facilitating clonal evolution.
Department of Biochemistry; Molecular Biology, and Biophysics ; University of Minnesota Medical School ; Minneapolis, MN USA.
Eric A
EA
Hendrickson
Institute of Cancer and Genetics; School of Medicine ; Cardiff University, Heath Park ; Cardiff, UK.
Duncan M
DM
Baird
DNA repair; cancer; ligase III; non-homologous end joining; telomerase; telomere