Synthesis, nematocidal activity and docking study of novel chiral 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives.
A series of novel chiral fluorinated pyrazole carboxamides derivatives were designed and synthesized. All these title compounds were confirmed by NMR and MS. The primarily nematocidal activity results indicated that some of them exhibited good control efficacy against the tomato root-knot nematode disease caused by Meloidogyne incognita. The docking results indicated that compound 5n interact with amino acid residue Tyr 121, Trp 279 of AchE via hydrogen bond.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Xing-Hai
XH
Liu
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China; Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, Hangzhou 310023, China.
Wen
W
Zhao
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Zhong-Hua
ZH
Shen
Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, Hangzhou 310023, China.
Jia-Hua
JH
Xing
Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, Hangzhou 310023, China.
Jing
J
Yuan
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Guo
G
Yang
Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, Hangzhou 310023, China.
Tian-Ming
TM
Xu
Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, Hangzhou 310023, China.
Wei-Li
WL
Peng
D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D062105:Molecular Docking Simulation; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014431:Tylenchoidea / Q000187:drug effects*
D000969:Antinematodal Agents; D011720:Pyrazoles
Chiral chain; Docking; Nematocidal activity; Synthesis; Trifluoromethylpyrazole