Refractory Adult Primary Autoimmune Neutropenia that Responded to Alemtuzumab.
Primary autoimmune neutropenia (P-AIN) is an extremely rare disease. The most effective treatment for primary P-AIN is a granulocyte colony-stimulating factor; however, no curative treatment has been reported. We herein report a case of an adult P-AIN patient with a relatively mild medical history (irrespective of the severe neutropenia) who showed a sustained hematological response over seventeen months after the initiation of treatment with subcutaneous Alemtuzumab.
Department of Medicine, SUNY Stony Brook University Hospital, USA.
Anu R
AR
Neerukonda
Fengshuo
F
Lan
Theodore
T
Gabig
Takeshi
T
Saraya
D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000276:immunology* / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000151:congenital / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D016896:Treatment Outcome; D044465:White People
D061067:Antibodies, Monoclonal, Humanized