The PREX1/Rac signaling axis: Potential as a biomarker and therapeutic target in breast cancer.
PREX1 is a Rac guanine exchange factor that coordinates signaling inputs from G protein-coupled receptors and receptor tyrosine kinases (RTKs). PREX1 creates a positive feedback loop to drive RTK, phosphatidylinositol 3-kinase (PI3K)/AKT, and MEK/ERK signaling. High PREX1 levels predict sensitivity to PI3K inhibitors in breast cancer cells.
Department of Pharmacology and Toxicology; Norris Cotton Cancer Center; Geisel School of Medicine at Dartmouth; Dartmouth-Hitchcock Medical Center ; Lebanon, NH, USA.
Lloye M
LM
Dillon
Department of Pharmacology and Toxicology; Norris Cotton Cancer Center; Geisel School of Medicine at Dartmouth; Dartmouth-Hitchcock Medical Center; Lebanon, NH, USA; Comprehensive Breast Program; Norris Cotton Cancer Center; Geisel School of Medicine at Dartmouth; Dartmouth-Hitchcock Medical Center; Lebanon, NH, USA.
Todd W
TW
Miller
MEK; P-REX1; PI3K; breast cancer