Tropomyosins in the healthy and diseased nervous system.
Regulation of the actin cytoskeleton is dependent on a plethora of actin-associated proteins in all eukaryotic cells. The family of tropomyosins plays a key role in controlling the function of several of these actin-associated proteins and their access to actin filaments. In order to understand the regulation of the actin cytoskeleton in highly dynamic subcellular compartments of neurons such as growth cones of developing neurons and the synaptic compartment of mature neurons, it is pivotal to decipher the functional role of tropomyosins in the nervous system. In this review, we will discuss the current understanding and recent findings on the regulation of the actin cytoskeleton by tropomyosins and potential implication that this has for the dysregulation of the actin cytoskeleton in neurological diseases.
Neurodegeneration and Repair Unit, School of Medical Sciences, University of New South Wales, 2052 Sydney, New South Wales, Australia.
Merryn
M
Brettle
Neurodegeneration and Repair Unit, School of Medical Sciences, University of New South Wales, 2052 Sydney, New South Wales, Australia.
Shrujna
S
Patel
Neurodegeneration and Repair Unit, School of Medical Sciences, University of New South Wales, 2052 Sydney, New South Wales, Australia. Electronic address: t.fath@unsw.edu.au.
Thomas
T
Fath
D000818:Animals; D002490:Central Nervous System / Q000254:growth & development / Q000378:metabolism*; D002493:Central Nervous System Diseases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D014335:Tropomyosin / Q000235:genetics / Q000378:metabolism*
D014335:Tropomyosin
Actin cytoskeleton; Central nervous system; Neurite outgrowth; Regeneration; Tropomyosin