Modeling Development and Disease with Organoids.
Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key structural and functional properties of organs such as kidney, lung, gut, brain and retina. Organoid technology can therefore be used to model human organ development and various human pathologies 'in a dish." Additionally, patient-derived organoids hold promise to predict drug response in a personalized fashion. Organoids open up new avenues for regenerative medicine and, in combination with editing technology, for gene therapy. The many potential applications of this technology are only beginning to be explored.
Hubrecht Institute/Royal Netherlands Academy of Arts and Sciences, Princess Maxima Centre and University Medical Centre Utrecht, 3584CT Utrecht, The Netherlands. Electronic address: h.clevers@hubrecht.eu.
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D000818:Animals; D006801:Humans; D008954:Models, Biological; D009928:Organ Specificity; D009940:Organoids / Q000166:cytology*; D017423:Sequence Analysis, RNA; D059010:Single-Cell Analysis; D013234:Stem Cells / Q000166:cytology