A New Monoterpenoid and a New Flavonoid Glycoside from the Peels of Clausena lansium.
One new monoterpenoid, nerol oxide-8-carboxylic acid (1), and one new flavonoid glycoside, claulansoside A (2), together with six known compounds, clausenamide (3), quercetin (4), isorhamnetin (5), dihydromyric (6), 2",3"-dihydroxyanisolactone (7) and (E,E)-8-(7-hydroxy-3,7-dimethylocta-2,5-dienyloxy)psoralen (8), have been isolated from the peels of Clausena lansium (Lour.) Skeels. Their structures were determined using a combination of 1D, and 2D NMR (HMQC, HMBC, COSY and NOESY) techniques, and HR-ESI-MS analyses. Compounds 1 and 7 exhibited antibacterial activity against Staphylococcus aureus with the diameter of inhibition zones of 11.5 mm and 14.2 mm. Compounds 3 and 6 showed α-glucosidase inhibitory activity in vitro.
Hui-Dong
HD
Deng
Cai-Hong
CH
Cai
Shuai
S
Liu
Yan-Bo
YB
Zeng
Wen-Li
WL
Mei
Fan
F
He
Min
M
Hua
Hao-Fu
HF
Dai
Shao-Peng
SP
Li
D000080462:Acyclic Monoterpenes; D054700:Clausena / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D005638:Fruit / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification*
D000080462:Acyclic Monoterpenes; D005419:Flavonoids; D039821:Monoterpenes; C000609526:claulansoside A; C000609525:nerol oxide-8-carboxylic acid