Lu-177 preparation for radiotherapy application.
A separation study using a (176)Yb target for the preparation of nca (177)Lu, which is a beta-emitting nuclide used not only in radioimmunotherapy applications but also in the treatment of various lesions, has been performed. A material having a better selectivity and separation efficiency for Lu than Yb was developed, and the separation conditions of (177)Lu were derived using this from a neutron irradiated (176)Yb target. The separation material was an organo-ceramic hybrid material containing a phosphate group. Adsorption behavior was determined through batch experiments, and (177)Lu separation from the Yb target was evaluated through column experiments. The Yb target, with a 99.72% in (176)Yb, was irradiated in the irradiation hole of HANARO, which has a thermal neutron flux of 1.6E+14ncm(-2)s(-1). The batch experiments revealed that the organo-ceramic hybrid material (Sol-POS) had a separation factor of 1.6 at 0.5M HCl. Separation was performed through extraction chromatography using a 5mg enriched Yb target, and the separation yield of the NCA (177)Lu was about 78%. If the amount of Yb target is increased to produce curies level (177)Lu, additional purification will be needed.
Korea Atomic Energy Research Institute, Dukjin-dong, Yuseong-gu, Daejeon 34057, Republic of Korea; Instrumental Analysis Laboratory, Department of Chemistry, Dongguk University, Seoul 04620, Republic of Korea. Electronic address: ujpark@kaeri.re.kr.
Ul Jae
UJ
Park
Korea Atomic Energy Research Institute, Dukjin-dong, Yuseong-gu, Daejeon 34057, Republic of Korea.
Jun-Sig
JS
Lee
Korea Atomic Energy Research Institute, Dukjin-dong, Yuseong-gu, Daejeon 34057, Republic of Korea.
Kang Hyuk
KH
Choi
Korea Atomic Energy Research Institute, Dukjin-dong, Yuseong-gu, Daejeon 34057, Republic of Korea.
Sung Soo
SS
Nam
Instrumental Analysis Laboratory, Department of Chemistry, Dongguk University, Seoul 04620, Republic of Korea. Electronic address: yukook@dongguk.edu.
Kook Hyun
KH
Yu
D000327:Adsorption; D002614:Chelating Agents; D002845:Chromatography / Q000379:methods; D006801:Humans; D008187:Lutetium / Q000302:isolation & purification* / Q000627:therapeutic use; D009502:Neutrons; D011868:Radioisotopes / Q000302:isolation & purification* / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000302:isolation & purification* / Q000627:therapeutic use; D056910:Republic of Korea; D013679:Technology, Radiologic / Q000295:instrumentation / Q000379:methods; D015018:Ytterbium / Q000528:radiation effects
D002614:Chelating Agents; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D008187:Lutetium; C000615061:Lutetium-177; D015018:Ytterbium
Chelate adsorbent; HANARO; Lutetium-177; Organo-ceramic hybrid material