Zebrafish kidney development.
The kidney of the zebrafish shares many features with other vertebrate kidneys including the human kidney. Similar cell types and shared developmental and patterning mechanisms make the zebrafish pronephros a valuable model for kidney organogenesis. Here we review recent advances in studies of zebrafish pronephric development and provide experimental protocols to analyze kidney cell types and structures, measure nephron function, live image kidney cells in vivo, and probe mechanisms of kidney regeneration after injury.
Massachusetts General Hospital, Charlestown, MA, United States.
I A
IA
Drummond
The University of Auckland, Auckland, New Zealand.
A J
AJ
Davidson
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007668:Kidney / Q000254:growth & development*; D009399:Nephrons / Q000254:growth & development; D038081:Organogenesis / Q000235:genetics*; D060910:Pronephros / Q000254:growth & development; D012038:Regeneration / Q000235:genetics*; D015027:Zebrafish / Q000235:genetics / Q000254:growth & development
Kidney; Nephron; Organogenesis; Pronephros; Regeneration