Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis.
Backgrounds. Heme oxygenase-1 (HO-1) has been reported to play a regulatory role in osteoclastogenesis. Bone morphogenetic protein (BMP) pathways induce osteoblastic differentiation and bone remodeling. Aims. To identify serum levels of HO-1, BMP-7, and Runt related-transcription factor 2 (Runx2) in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) and to investigate the relationships between HO-1, BMP-7, Runx2, and other common biomarkers for bone metabolism. Results. Serum levels of HO-1 and BMP-7 were revealed to be significantly higher in patients with RA or AS than in healthy controls (p < 0.01). In RA group, HO-1 was positively correlated with BMP-7, Runx2, and tartrate-resistant acid phosphatase-5b (TRAP-5b) (p < 0.05, resp.), BMP-7 was positively correlated with Runx2 and TRAP-5b (p < 0.05, resp.), and Runx2 was negatively correlated with N-terminal midfragment of osteocalcin (NMID) (p < 0.05). In AS group, we observed identical correlation between HO-1 and BMP-7, but opposite correlations between BMP-7 and TRAP-5b and between Runx2 and NMID, when comparing with the RA cohort. Conclusion. Our findings suggest that HO-1 and BMP-7 are potential biomarkers for bone metabolism in patients with RA and AS. The different correlations between the bone markers point to distinct differences in bone remodeling pathways in the two types of arthritis.
Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Tong-Ling
TL
Yuan
Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Jin
J
Chen
Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Yan-Li
YL
Tong
Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Yan
Y
Zhang
Department of Health Statistics, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Yuan-Yuan
YY
Liu
Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan; Institute of Integrative Medicine, China Medical University, Taichung 40201, Taiwan.
James Cheng-Chung
JC
Wei
Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Yi
Y
Liu
Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Yi
0000-0002-8522-8906
Y
Zhao
Department of Internal Medicine 3, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.
Martin
M
Herrmann
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood*; D055419:Bone Morphogenetic Protein 7 / Q000097:blood*; D001842:Bone and Bones / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D051547:Heme Oxygenase-1 / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000378:metabolism*
D015415:Biomarkers; D055419:Bone Morphogenetic Protein 7; D051547:Heme Oxygenase-1