Metabolic rewiring in cancer-associated fibroblasts provides a niche for oncogenesis and metastatic dissemination.
Cancer-associated fibroblasts (CAFs) are major participants in the crosstalk between tumor cells and their microenvironment. CAFs provide not only multiple soluble factors but also metabolic fuels to promote tumor growth, invasion, and metastasis. We discuss recent developments delineating the effects of metabolic symbiosis between CAFs and tumor cells on tumor growth.
The State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China; Department of Molecular and Cellular Biochemistry; Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Jingyi
J
Liu
Department of Biochemistry & Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai JiaoTong University School of Medicine , Shanghai, China.
Jun
J
Mi
Department of Molecular and Cellular Biochemistry; Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Binhua P
BP
Zhou
Alpha-ketoglutarate; IDH; cancer-associated; fibroblast; metabolic symbiosis; metastasis; tumor microenvironment