Differences in strength-duration curves of electrical diagnosis by physiotherapists between DJ-1 homozygous knockout and wild-type mice: a randomized controlled pilot trial.
[Purpose] Strength-duration (SD) curves are used in electrical diagnosis by physiotherapists to confirm muscle degeneration. However, the usefulness of SD curves in comparing muscle degeneration in DJ-1 homozygous knockout (DJ-1(-/-)) and wild-type mice (DJ-1(+/+)) is not yet fully understood. The electrical properties of the gastrocnemius muscles of DJ-1(-/-) and DJ-1(+/+) mice were compared in the current study. [Subjects and Methods] The electrode of an electrical stimulator was applied to the gastrocnemius muscle to measure the rheobase until the response of contractive muscle to electrical stimulation became visible in mice. [Results] The rheobase of DJ-1(-/-) mice showed a significant increase in a time-dependent manner, compared to that of DJ-1(+/+) mice. [Conclusion] These results demonstrate that the DJ-1 protein may be implicated in the regulation of neuromuscular activity of gastrocnemius muscles of mice.
Department of Physical Therapy, College of Health Welfare, Wonkwang Health Science University, Republic of Korea.
Ju-Hyun
JH
Kim
Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of Korea.
Won-Deok
WD
Lee
Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of Korea.
Mee-Young
MY
Kim
Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of Korea; Commercializations Promotion Agency for R&D Outcomes, Republic of Korea.
Lim-Kyu
LK
Lee
Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of Korea.
Byoung-Sun
BS
Park
Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of Korea.
Seung-Min
SM
Yang
Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of Korea.
Ji-Woong
JW
Noh
Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of Korea.
Yong-Sub
YS
Shin
Department of Physical Therapy, College of Health Science, Honam University, Republic of Korea.
Jeong-Uk
JU
Lee
Department of Taekwondo Instructor Education, College of Martial Arts, Yongin University, Republic of Korea.
Taek-Yong
TY
Kwak
Department of Combative Martial Arts Training, College of Martial Arts, Yongin University, Republic of Korea.
Tae-Hyun
TH
Lee
Department of Social Welfare, College of Public Health and Welfare, Yongin University, Republic of Korea.
Jaehong
J
Park
Department of Medicine, Institute of Functional Genomics, School of Medicine, Konkuk University, Republic of Korea.
Bokyung
B
Kim
Department of Physical Therapy, College of Public Health and Welfare, Yongin University, Republic of Korea.
Junghwan
J
Kim
DJ-1; Physiotherapist; Strength-duration (SD) curves