MicroRNAs-from metastasis prediction to metastasis prevention?
Recently, we suggested the microRNA (miR) landscape defining metastasis. The first miR-driven network orchestrating invasion, intravasation, and metastasis was confirmed independently across several malignancies, suggesting a rather general principle for metastasis regulation. We hope that our data will stimulate the field in terms of further hypothesis generation, metastasis prediction, and metastasis prevention.
Department of Experimental Surgery, Medical Faculty Mannheim, Theodor Kutzer Ufer 1-3, 68135 Mannheim, Ruprecht Karl University of Heidelberg, Germany; Centre for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Ludolf-Krehl-Str. 6, 68135 Mannheim, Ruprecht Karl University of Heidelberg, Germany.
Mohammed
M
Abba
Department of Experimental Surgery, Medical Faculty Mannheim, Theodor Kutzer Ufer 1-3, 68135 Mannheim, Ruprecht Karl University of Heidelberg, Germany; Centre for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Ludolf-Krehl-Str. 6, 68135 Mannheim, Ruprecht Karl University of Heidelberg, Germany.
Nitin
N
Patil
Department of Experimental Surgery, Medical Faculty Mannheim, Theodor Kutzer Ufer 1-3, 68135 Mannheim, Ruprecht Karl University of Heidelberg, Germany; Centre for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Ludolf-Krehl-Str. 6, 68135 Mannheim, Ruprecht Karl University of Heidelberg, Germany.
Jörg Hendrik
JH
Leupold
Department of Experimental Surgery, Medical Faculty Mannheim, Theodor Kutzer Ufer 1-3, 68135 Mannheim, Ruprecht Karl University of Heidelberg, Germany; Centre for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Ludolf-Krehl-Str. 6, 68135 Mannheim, Ruprecht Karl University of Heidelberg, Germany.
Heike
H
Allgayer
Cancer; EMT; FOXN3; metastasis; microRNA; stem cell