Controllable degradation of medical magnesium by electrodeposited composite films of mussel adhesive protein (Mefp-1) and chitosan.
To control the degradation rate of medical magnesium in body fluid environment, biocompatible films composed of Mussel Adhesive Protein (Mefp-1) and chitosan were electrodeposited on magnesium surface in cathodic constant current mode. The compositions and structures of the films were characterized by atomic force microscope (AFM), scanning electron microscope (SEM) and infrared reflection absorption spectroscopy (IRAS). And the corrosion protection performance was investigated using electrochemical measurements and immersion tests in simulated body fluid (Hanks' solution). The results revealed that Mefp-1 and chitosan successfully adhered on the magnesium surface and formed a protective film. Compared with either single Mefp-1 or single chitosan film, the composite film of chitosan/Mefp-1/chitosan (CPC (chitosan/Mefp-1/chitosan)) exhibited lower corrosion current density, higher polarization resistance and more homogenous corrosion morphology and thus was able to effectively control the degradation rate of magnesium in simulated body environment. In addition, the active attachment and spreading of MC3T3-E1 cells on the CPC film coated magnesium indicated that the CPC film was significantly able to improve the biocompatibility of the medical magnesium.
State Key Laboratory for Physical Chemistry of Solid Surfaces, and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Ping-Li
PL
Jiang
State Key Laboratory for Physical Chemistry of Solid Surfaces, and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Rui-Qing
RQ
Hou
State Key Laboratory for Physical Chemistry of Solid Surfaces, and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Cheng-Dong
CD
Chen
State Key Laboratory for Physical Chemistry of Solid Surfaces, and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. Electronic address: sunlan@xmu.edu.cn.
Lan
L
Sun
College of Energy and School of Energy Research, Xiamen University, Xiamen 361005, China.
Shi-Gang
SG
Dong
Div. of Surface and Corrosion Science, Dept. of Chemistry, Royal Institute of Technology, Drottning Kristinasväg, 51, SE-100 44 Stockholm, Sweden.
Jin-Shan
JS
Pan
State Key Laboratory for Physical Chemistry of Solid Surfaces, and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China; College of Energy and School of Energy Research, Xiamen University, Xiamen 361005, China. Electronic address: cjlin@xmu.edu.cn.
Chang-Jian
CJ
Lin
D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D055664:Electrochemical Techniques; D008274:Magnesium / Q000737:chemistry*; D008974:Mollusca / Q000737:chemistry; D010316:Particle Size; D011506:Proteins / Q000737:chemistry*; D013499:Surface Properties
D020099:Coated Materials, Biocompatible; D011506:Proteins; C037403:adhesive protein, mussel; D048271:Chitosan; D008274:Magnesium
Biocompatiblity; Chitosan; Corrosion protection; Magnesium; Mussel adhesive protein (Mefp-1)