Caryocar coriaceum Wittm. (Pequi) fixed oil presents hypolipemic and anti-inflammatory effects in vivo and in vitro.
Caryocar coriaceum Wittm. (Pequi) is found in southern Ceará, where the fruit is used as food and in folk medicine as an anti-inflammatory, and to promote healing. However, little is known about the effects of repeated administration of its oil on the biochemical parameters of the blood. This work aimed to evaluate the effects Caryocar coriaceum fixed oil (OFCC); on the lipid profiles of healthy mice, on dyslipidemia induced by tyloxapol, and to study its anti-inflammatory effect both in vivo and in vitro. The results revealed significant reduction in total serum cholesterol and triglycerides, and an increase in HDL-C. The paw edema (induced by carrageenan) and myeloperoxidase (MPO), in polymorphonuclear culture cells, was reduced at all dose levels. Results demonstrated that Caryocar coriaceum's fix oil present anti-inflammatory activity and, for the first time describe the hypolipidemic effects, supporting its traditional use and suggest that present a potential cardioprotective effect.
Laboratório de Biofisiologia e Farmacologia, Faculdade de Medicina Estácio de Juazeiro do Norte - Estácio/FMJ, Avenida Tenente Raimundo Rocha s/n, CEP 63040-360 Juazeiro do Norte, Brazil.
Patrícia Rosane Leite
PRL
de Figueiredo
Laboratório de Biofisiologia e Farmacologia, Faculdade de Medicina Estácio de Juazeiro do Norte - Estácio/FMJ, Avenida Tenente Raimundo Rocha s/n, CEP 63040-360 Juazeiro do Norte, Brazil.
Isabella Bezerra
IB
Oliveira
Laboratório de Biofisiologia e Farmacologia, Faculdade de Medicina Estácio de Juazeiro do Norte - Estácio/FMJ, Avenida Tenente Raimundo Rocha s/n, CEP 63040-360 Juazeiro do Norte, Brazil.
José Benício Santana
JBS
Neto
Laboratório de Biofisiologia e Farmacologia, Faculdade de Medicina Estácio de Juazeiro do Norte - Estácio/FMJ, Avenida Tenente Raimundo Rocha s/n, CEP 63040-360 Juazeiro do Norte, Brazil.
Juliana Albuquerque
JA
de Oliveira
Laboratório de Biofisiologia e Farmacologia, Faculdade de Medicina Estácio de Juazeiro do Norte - Estácio/FMJ, Avenida Tenente Raimundo Rocha s/n, CEP 63040-360 Juazeiro do Norte, Brazil.
Larissa Bernardo
LB
Ribeiro
Laboratório de Biofisiologia e Farmacologia, Faculdade de Medicina Estácio de Juazeiro do Norte - Estácio/FMJ, Avenida Tenente Raimundo Rocha s/n, CEP 63040-360 Juazeiro do Norte, Brazil.
Glauce Socorro
GS
de Barros Viana
Laboratório de Farmacognosia, Universidade Federal do Ceará - UFC, Rua Capitão Francisco Pedro, 1210, Rodolfo Teófilo, CEP 60430-370 Fortaleza, Brazil.
Talita Magalhães
TM
Rocha
Laboratório de Farmacognosia, Universidade Federal do Ceará - UFC, Rua Capitão Francisco Pedro, 1210, Rodolfo Teófilo, CEP 60430-370 Fortaleza, Brazil.
Luzia Kalyne Almeida Moreira
LKAM
Leal
Laboratório de Farmacologia e Química Molecular - LFQM, Universidade Regional do Cariri - URCA, Rua Cel Antônio Luiz, 1161, Pimenta, CEP 63105-000 Crato, Brazil.
Marta Regina
MR
Kerntopf
Departamento de Biologia Molecular - DBM, Universidade Federal da Paraíba - UFPB, Campus I - Jardim Cidade Universitária, CEP 58059-900 João Pessoa, Brazil.
Cícero Francisco Bezerra
CFB
Felipe
Laboratório de Microbiologia e Biologia Molecular - LMBM Universidade Regional do Cariri - URCA, Rua Cel Antônio Luiz, 1161, Pimenta, CEP 63105-000, Crato, Brazil.
Henrique Douglas Melo
HDM
Coutinho
Laboratório de Farmacologia e Química Molecular - LFQM, Universidade Regional do Cariri - URCA, Rua Cel Antônio Luiz, 1161, Pimenta, CEP 63105-000 Crato, Brazil. Electronic address: irwinalencar@yahoo.com.br.
Irwin Rose
IR
de Alencar Menezes
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D002351:Carrageenan; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D050171:Dyslipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D020448:Ericales / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D000960:Hypolipidemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D008055:Lipids / Q000097:blood*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010938:Plant Oils / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D011092:Polyethylene Glycols; D017208:Rats, Wistar; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D010938:Plant Oils; D011092:Polyethylene Glycols; D002351:Carrageenan; D009195:Peroxidase; C016811:tyloxapol
Caryocar coriaceum wittm; Dyslipidemia; Inflammation; Monounsaturated fatty acids; Myeloperoxidase; Pequi