Neoadjuvant Treatment With Cyclooxygenase-2 Inhibitor and Prednisolone Allows Conservative Surgery for Inflammatory Myofibroblastic Tumor of the Bladder.
Inflammatory myofibroblastic tumor (IMT), which expresses cyclooxygenase-2 (COX-2), can be effectively treated with COX-2 inhibitor. Here, we report a case of urinary bladder IMT in a 13-year-old boy. Although total cystectomy was initially planned for complete resection of the tumor, neoadjuvant treatment with COX-2 inhibitor and prednisolone reduced the size of the tumor and enabled complete resection of the tumor by partial cystectomy. Neoadjuvant treatment with COX-2 inhibitor and prednisolone for IMT of the bladder allowed a more conservative surgical procedure that preserved bladder function.
Departments of *Pediatrics †Urology, Graduate School of Medical Science ‡Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yusuke
Y
Tsuma
Mitsuru
M
Miyachi
Kazutaka
K
Ouchi
Kunihiko
K
Tsuchiya
Tomoko
T
Iehara
Yasuyuki
Y
Naitoh
Eiichi
E
Konishi
Akio
A
Yanagisawa
Hajime
H
Hosoi
D000293:Adolescent; D000072700:Conservative Treatment / Q000379:methods; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use*; D015653:Cystectomy / Q000379:methods; D006801:Humans; D007249:Inflammation; D008297:Male; D020360:Neoadjuvant Therapy / Q000379:methods*; D009379:Neoplasms, Muscle Tissue / Q000473:pathology / Q000601:surgery*; D011239:Prednisolone / Q000627:therapeutic use*; D001749:Urinary Bladder Neoplasms / Q000601:surgery*
D052246:Cyclooxygenase 2 Inhibitors; D011239:Prednisolone