Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer.
Resistance to antiestrogen therapy remains a critical determinant of mortality in patients affected by ER+ breast cancer. Our previous work identified autophagy and interferon regulatory factor 1 (IRF1) signaling as key regulators of this process. We have recently demonstrated a novel reciprocal interaction between IRF1 and ATG7, linking inflammation and autophagy.
Department of Oncology and Lombardi Comprehensive Cancer Center; Georgetown University Medical Center, Washington, DC USA; Department of Surgery, Hypertension and Vascular Research Center, Wake Forest Comprehensive Cancer Center; Wake Forest University, Winston-Salem, NC USA.
Katherine L
KL
Cook
Department of Oncology and Lombardi Comprehensive Cancer Center; Georgetown University Medical Center , Washington, DC USA.
Jessica L
JL
Schwartz-Roberts
Bradley Department of Electrical and Computer Engineering Virginia Polytechnic Institute and State University , Blacksburg, VA USA.
William T
WT
Baumann
Department of Oncology and Lombardi Comprehensive Cancer Center; Georgetown University Medical Center , Washington, DC USA.
Robert
R
Clarke
ATG7; IRF1 tumor suppressor; autophagy; breast cancer; estrogen receptor; unfolded protein response