Computational Assessment of Neural Probe and Brain Tissue Interface under Transient Motion.
The functional longevity of a neural probe is dependent upon its ability to minimize injury risk during the insertion and recording period in vivo, which could be related to motion-related strain between the probe and surrounding tissue. A series of finite element analyses was conducted to study the extent of the strain induced within the brain in an area around a neural probe. This study focuses on the transient behavior of neural probe and brain tissue interface with a viscoelastic model. Different stages of the interface from initial insertion of neural probe to full bonding of the probe by astro-glial sheath formation are simulated utilizing analytical tools to investigate the effects of relative motion between the neural probe and the brain while friction coefficients and kinematic frequencies are varied. The analyses can provide an in-depth look at the quantitative benefits behind using soft materials for neural probes.
Department of Mechanical and Aerospace Engineering, Old Dominion University, Norfolk, VA 23529, USA. mpola002@odu.edu.
Michael
M
Polanco
Department of Mechanical and Aerospace Engineering, Old Dominion University, Norfolk, VA 23529, USA. sbawab@odu.edu.
Sebastian
S
Bawab
Department of Engineering, Center for Materials Research, Norfolk State University, Norfolk, VA 23504, USA. hyoon@nsu.edu.
Hargsoon
H
Yoon
D001696:Biomechanical Phenomena; D001921:Brain; D055119:Elastic Modulus; D004567:Electrodes, Implanted; D020342:Finite Element Analysis; D008839:Microelectrodes; D008962:Models, Theoretical; D009038:Motion; D013314:Stress, Mechanical
brain; finite element analysis; neural electrodes; viscoelasticity