Dousing fire with gasoline: interplay between lysosome damage and the NLRP3 inflammasome. Focus on "NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx".
Diabetic Cardiovascular Disease Center, Department of Medicine, and Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri schillij@wustl.edu.
Joel D
JD
Schilling
D005742:Gasoline; D058847:Inflammasomes; D053583:Interleukin-1beta; D008247:Lysosomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D015398:Signal Transduction
D005742:Gasoline; D058847:Inflammasomes; D053583:Interleukin-1beta; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein