Clinical significance of HOTAIR expression in colon cancer.
OBJECTIVE
To detect the expression of the long noncoding RNA HOTAIR in colon cancer and analyze its relationship with clinicopathological parameters of colon cancer.


METHODS
Total RNA was extracted from 80 colon cancer tissues and matched tumor-adjacent normal colon tissues and reverse transcribed. Quantitative polymerase chain reaction was used to detect the expression of HOTAIR. The relationship between the expression of HOTAIR and clinicopathological parameters of colon cancer was analyzed.


RESULTS
The expression of HOTAIR was significantly higher in colon cancer tissues than in matched tumor-adjacent normal colon tissues (P < 0.05). HOTAIR expression was significantly higher in cases with lymph node metastasis than in those without metastasis; in lowly differentiated and undifferentiated cases than in highly and moderately differentiated cases; and in stages III + IV cases than in stages I + II cases (P < 0.05).


CONCLUSIONS
HOTAIR expression is upregulated in colon cancer, suggesting that HOTAIR plays an important role in the tumorigenesis, development and metastasis of colon cancer. HOTAIR may act as an oncogene and represents a new molecular target for the treatment of colon cancer.
Zhi-Fen Luo, Xi-Qing Li, Yong-Xia Cui, Ning Ma, Chuang-Xin Lu, Ming-Yue Liu, Yun Zhou, Department of Oncology, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China.
Zhi-Fen
ZF
Luo
Zhi-Fen Luo, Xi-Qing Li, Yong-Xia Cui, Ning Ma, Chuang-Xin Lu, Ming-Yue Liu, Yun Zhou, Department of Oncology, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China.
Dan
D
Zhao
Zhi-Fen Luo, Xi-Qing Li, Yong-Xia Cui, Ning Ma, Chuang-Xin Lu, Ming-Yue Liu, Yun Zhou, Department of Oncology, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China.
Xi-Qing
XQ
Li
Zhi-Fen Luo, Xi-Qing Li, Yong-Xia Cui, Ning Ma, Chuang-Xin Lu, Ming-Yue Liu, Yun Zhou, Department of Oncology, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China.
Yong-Xia
YX
Cui
Zhi-Fen Luo, Xi-Qing Li, Yong-Xia Cui, Ning Ma, Chuang-Xin Lu, Ming-Yue Liu, Yun Zhou, Department of Oncology, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China.
Ning
N
Ma
Zhi-Fen Luo, Xi-Qing Li, Yong-Xia Cui, Ning Ma, Chuang-Xin Lu, Ming-Yue Liu, Yun Zhou, Department of Oncology, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China.
Chuang-Xin
CX
Lu
Zhi-Fen Luo, Xi-Qing Li, Yong-Xia Cui, Ning Ma, Chuang-Xin Lu, Ming-Yue Liu, Yun Zhou, Department of Oncology, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China.
Ming-Yue
MY
Liu
Zhi-Fen Luo, Xi-Qing Li, Yong-Xia Cui, Ning Ma, Chuang-Xin Lu, Ming-Yue Liu, Yun Zhou, Department of Oncology, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China.
Yun
Y
Zhou
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D002454:Cell Differentiation; D003110:Colonic Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D062085:RNA, Long Noncoding / Q000235:genetics*; D012189:Retrospective Studies; D015854:Up-Regulation
D014408:Biomarkers, Tumor; C561566:HOTAIR long untranslated RNA, human; D062085:RNA, Long Noncoding
Colon tumor; HOTAIR; Long non-coding RNA; Oncogene