Oxidative Radical Addition-Cyclization of Sulfonyl Hydrazones with Simple Olefins by Binary Acid Catalysis.
An unprecedented binary acid accelerated oxidative radical annulation of sulfonyl hydrazones with simple olefins is described. Notably, this method provides a novel oxidative radical cycloaddition for the construction of six-member heterocycles. It offers a rapid and efficient approach to tetrahydropyridazines which are key structural motifs in pharmaceutically active compounds.
Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing, 100190, China.|University of Chinese Academy of Sciences , Beijing, 100049, China.
Xingren
X
Zhong
Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing, 100190, China.|University of Chinese Academy of Sciences , Beijing, 100049, China.|Collaborative Innovation Center of Chemical and Engineering (Tianjin), Tianjin, 300071, China.
Jian
J
Lv
Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing, 100190, China.|University of Chinese Academy of Sciences , Beijing, 100049, China.|Collaborative Innovation Center of Chemical and Engineering (Tianjin), Tianjin, 300071, China.
Sanzhong
S
Luo