Idiopathic hypereosinophilic syndrome presenting with hepatitis and achalasia.
Idiopathic hypereosinophilic syndrome (HES) is a rare diagnosis defined by the World Health Organization as a persistent eosinophilia for 6 months and resulting in end-organ dysfunction. While many patients present with nonspecific symptoms, others will present with symptoms of the affected organs, most commonly those involving the heart, skin, or nervous system. Gastrointestinal or liver involvement is estimated to affect up to one-third of patients with HES, although patients with clinically significant disease are limited to case reports. This is the first report of a patient presenting with hepatitis and achalasia related to idiopathic HES.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, SSM Health Saint Louis University Hospital, 3635 Vista Avenue, Saint Louis, MO, 63110, USA. amandacheung@slu.edu.
Amanda C
AC
Cheung
Division of Gastroenterology and Hepatology, Department of Internal Medicine, SSM Health Saint Louis University Hospital, 3635 Vista Avenue, Saint Louis, MO, 63110, USA.
Christine Y
CY
Hachem
Division of Anatomic Pathology, Department of Pathology, SSM Health Saint Louis University Hospital, Saint Louis, MO, USA.
Jinping
J
Lai
D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D004931:Esophageal Achalasia / Q000209:etiology* / Q000473:pathology; D006521:Hepatitis, Chronic / Q000209:etiology* / Q000473:pathology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged
Achalasia; Hepatitis; Hypereosinophilic syndrome