The Potential for Microalgae as Bioreactors to Produce Pharmaceuticals.
As photosynthetic organisms, microalgae can efficiently convert solar energy into biomass. Microalgae are currently used as an important source of valuable natural biologically active molecules, such as carotenoids, chlorophyll, long-chain polyunsaturated fatty acids, phycobiliproteins, carotenoids and enzymes. Significant advances have been achieved in microalgae biotechnology over the last decade, and the use of microalgae as bioreactors for expressing recombinant proteins is receiving increased interest. Compared with the bioreactor systems that are currently in use, microalgae may be an attractive alternative for the production of pharmaceuticals, recombinant proteins and other valuable products. Products synthesized via the genetic engineering of microalgae include vaccines, antibodies, enzymes, blood-clotting factors, immune regulators, growth factors, hormones, and other valuable products, such as the anticancer agent Taxol. In this paper, we briefly compare the currently used bioreactor systems, summarize the progress in genetic engineering of microalgae, and discuss the potential for microalgae as bioreactors to produce pharmaceuticals.
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. yanna19881204@163.com.|University of Chinese Academy of Sciences, Beijing 100049, China. yanna19881204@163.com.
Na
N
Yan
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. cmfan@genetics.ac.cn.
Chengming
C
Fan
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. yhchen@genetics.ac.cn.
Yuhong
Y
Chen
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. zmhu@genetics.ac.cn.
Zanmin
Z
Hu
D019149:Bioreactors; D005818:Genetic Engineering / Q000379:methods*; D007218:Industrial Microbiology / Q000295:instrumentation / Q000379:methods*; D058086:Microalgae / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism
D011994:Recombinant Proteins
bioreactor; microalgae; pharmaceuticals; recombinant proteins