Synthesis of Ferromagnetic Fe0.6 Mn0.4 O Nanoflowers as a New Class of Magnetic Theranostic Platform for In Vivo T1 -T2 Dual-Mode Magnetic Resonance Imaging and Magnetic Hyperthermia Therapy.
Uniform wüstite Fe0.6 Mn0.4 O nanoflowers have been successfully developed as an innovative theranostic agent with T1 -T2 dual-mode magnetic resonance imaging (MRI), for diagnostic applications and therapeutic interventions via magnetic hyperthermia. Unlike their antiferromagnetic bulk counterpart, the obtained Fe0.6 Mn0.4 O nanoflowers show unique room-temperature ferromagnetic behavior, probably due to the presence of an exchange coupling effect. Combined with the flower-like morphology, ferromagnetic Fe0.6 Mn0.4 O nanoflowers are demonstrated to possess dual-modal MRI sensitivity, with longitudinal relaxivity r1 and transverse relaxivity r2 as high as 4.9 and 61.2 mm(-1) s(-1) [Fe]+[Mn], respectively. Further in vivo MRI carried out on the mouse orthotopic glioma model revealed gliomas are clearly delineated in both T1 - and T2 -weighted MR images, after administration of the Fe0.6 Mn0.4 O nanoflowers. In addition, the Fe0.6 Mn0.4 O nanoflowers also exhibit excellent magnetic induction heating effects. Both in vitro and in vivo magnetic hyperthermia experimentation has demonstrated that magnetic hyperthermia by using the innovative Fe0.6 Mn0.4 O nanoflowers can induce MCF-7 breast cancer cell apoptosis and a complete tumor regression without appreciable side effects. The results have demonstrated that the innovative Fe0.6 Mn0.4 O nanoflowers can be a new magnetic theranostic platform for in vivo T1 -T2 dual-mode MRI and magnetic thermotherapy, thereby achieving a one-stop diagnosis cum effective therapeutic modality in cancer management.
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710069, China.|Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, 117574, Singapore.
Xiao Li
XL
Liu
Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore 4 Medical Drive, MD10, 117597, Singapore.
Cheng Teng
CT
Ng
Magnetic Resonance Imaging Group, Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR), 11 Biopolis Way, #02-02, Helios, 138667, Singapore.
Prashant
P
Chandrasekharan
State Key Laboratory of Magnetism and Beijing National Laboratory for Condensed Matter Physics, Chinese Academy of Sciences, Beijing, 100190, China.
Hai Tao
HT
Yang
Key Laboratory of Advanced Materials, Ministry of Education, School of Material Science and Engineering, Tsinghua University, Beijing, 100084, China.
Ling Yun
LY
Zhao
Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, 117574, Singapore.
Erwin
E
Peng
Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, 117574, Singapore.|NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, 117456, Singapore.
Yun Bo
YB
Lv
Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, 117574, Singapore.
Wen
W
Xiao
Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, 117574, Singapore.
Jie
J
Fang
School of Materials Science and Engineering, University of New South Wales, Kensington, NSW, 2052, Australia.
Jia Bao
JB
Yi
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710069, China.
Huan
H
Zhang
Magnetic Resonance Imaging Group, Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR), 11 Biopolis Way, #02-02, Helios, 138667, Singapore.
Kai-Hsiang
KH
Chuang
Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore 4 Medical Drive, MD10, 117597, Singapore.
Boon Huat
BH
Bay
Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, 117574, Singapore.
Jun
J
Ding
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710069, China.
Hai Ming
HM
Fan
D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D005290:Ferric Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D061986:MCF-7 Cells; D008279:Magnetic Resonance Imaging; D059346:Magnets / Q000737:chemistry*; D017895:Manganese Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D010087:Oxides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000068936:Theranostic Nanomedicine / Q000379:methods
D003287:Contrast Media; D005290:Ferric Compounds; D017895:Manganese Compounds; D010087:Oxides; C000499:ferric oxide; C027424:manganese oxide
Fe0.6Mn0.4O nanoflowers; T1-T2 dual-mode; exchange coupling effect; magnetic hyperthermia; magnetic resonance imaging