c-Abl forces YAP to switch sides.
Cancer research has been significantly accelerated by viewing cancer as a functional collision between 2 dichotomous sets of genes: oncogenes and tumor suppressors. Signaling pathways turn oncogenes and tumor suppressors on and off to dictate cell fate decisions. We contend that signaling also dictates opposing behaviors of a given effector.
Department of Molecular Genetics; Weizmann Institute of Science; Rehovot, Israel.
Rom
R
Keshet
Department of Molecular Genetics; Weizmann Institute of Science; Rehovot, Israel.
Nina
N
Reuven
Department of Molecular Genetics; Weizmann Institute of Science; Rehovot, Israel.
Yosef
Y
Shaul
Hippo pathway; YAP; apoptosis; c-Abl; oncogene; transformation; tumor suppressor