The cancer stem cell phenotype: You can't win until you learn how to lose it.
Cancer stem cells and their relatively differentiated progenitors coexist in dynamic equilibrium and are subject to bidirectional conversion. We recently showed that reprogramming transcription factors induce glioblastoma cells to become stem-like and tumor propagating via a mechanism involving changes in global DNA methylation and downregulation of miRNAs.
Hugo W. Moser Research Institute at Kennedy Krieger; Baltimore, MD, USA; Department of Neurology, Johns Hopkins School of Medicine; Baltimore, MD, USA.
Hernando
H
Lopez-Bertoni
Hugo W. Moser Research Institute at Kennedy Krieger; Baltimore, MD, USA; Department of Neurology, Johns Hopkins School of Medicine; Baltimore, MD, USA; Department of Neuroscience, Johns Hopkins School of Medicine; Baltimore, MD, USA; Department of Oncology, Johns Hopkins School of Medicine; Baltimore, MD, USA.
John
J
Laterra
DNA methylation; cancer stem cell; miRNAs; reprogramming transcription factors; tumorigenesis