Effect of Gallic Acid on Dementia Type of Alzheimer Disease in Rats: Electrophysiological and Histological Studies.
BACKGROUND
To study the effect of gallic acid (GA) on hippocampal long-term potentiation (LTP) and histological changes in animal model of Alzheimer disease (AD) induced by beta-amyloid (Aβ).


METHODS
Sixty-four adult male Wistar rats (300±20 g) were divided into 8 groups: 1) Control (Cont); 2) AD; 3) Sham; 4-7) AD+GA (50, 100, and 200 mg/kg for 10 days, orally) or vehicle, 8) Cont+GA100, Aβ (1μg/μL in each site) was infused into hippocampus bilaterally. Changes of amplitude and slope of LTP induced in hippocampal dentate gyrus (DG) were evaluated by high frequency stimulation (HFS) of perforant path (PP).


RESULTS
Data showed that LTP amplitude and area under curve significantly impaired in AD rats (P<0.001), while significantly improved in AD rats treated with GA (P<0.05, P<0.01).


CONCLUSIONS
Current findings suggest that GA reduces neural damage and brain amyloid neuropathology and improves cognitive function via free radicals scavenging and inhibiting oligomerization of Aβ but with no effect on healthy rats.
Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Somayeh
S
Hajipour
Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Alireza
A
Sarkaki
Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Yaghoob
Y
Farbood
Department of Biology, Sciences & Research Branch, Islamic Azad University, Tehran, Iran.
Akram
A
Eidi
Department of Pathology, Faculty of Specialized Veterinary Science, Science & Research Branch, Islamic Azad University, Tehran, Iran.
Pejman
P
Mortazavi
Department of Nursing and Midwifery, Dezfoul Branch, Islamic Azad University, Dezfoul, Iran.
Zohreh
Z
Valizadeh
Alzheimer disease; Beta-amyloid; Long-term potentiation; Neuronal apoptosis; Rat