Analytically tractable studies of traveling waves of activity in integrate-and-fire neural networks.
In contrast to other large-scale network models for propagation of electrical activity in neural tissue that have no analytical solutions for their dynamics, we show that for a specific class of integrate and fire neural networks the acceleration depends quadratically on the instantaneous speed of the activity propagation. We use this property to analytically compute the network spike dynamics and to highlight the emergence of a natural time scale for the evolution of the traveling waves. These results allow us to examine other applications of this model such as the effect that a nonconductive gap of tissue has on further activity propagation. Furthermore we show that activity propagation also depends on local conditions for other more general connectivity functions, by converting the evolution equations for network dynamics into a low-dimensional system of ordinary differential equations. This approach greatly enhances our intuition into the mechanisms of the traveling waves evolution and significantly reduces the simulation time for this class of models.
Department of Mathematics and Statistics, Georgia State University, Atlanta, Georgia 30303, USA.
Jie
J
Zhang
Department of Mathematics and Statistics, Georgia State University, Atlanta, Georgia 30303, USA.|Neuroscience Institute, Georgia State University, Atlanta, Georgia 30093, USA.
Remus
R
Osan
D000200:Action Potentials; D008959:Models, Neurological; D016571:Neural Networks, Computer; D009474:Neurons / Q000502:physiology; D013997:Time Factors