Adult brainstem gliomas.
Brainstem gliomas in adults are a rare and heterogeneous group of brain tumors that vary with regard to underlying pathology, radiographic appearance, clinical course and prognosis. Diffuse intrinsic pontine gliomas represent the most common subtype. Although still considered aggressive and most often lethal, these brain tumors are associated with a more insidious clinical course and more favorable prognosis compared to the highly aggressive form in children. Treatment options for patients with brainstem gliomas still are limited and insufficiently studied. A better understanding of the pathobiology of these tumors will be crucial for the development of more specific and effective therapies. Cancer 2016. © 2016 American Cancer Society. Cancer 2016;122:2799-2809. © 2016 American Cancer Society.
Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts.
Sylvia C
SC
Eisele
Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts.
David A
DA
Reardon
D000328:Adult; D020295:Brain Stem Neoplasms / Q000473:pathology* / Q000628:therapy; D005910:Glioma / Q000473:pathology* / Q000628:therapy; D006801:Humans; D011379:Prognosis
adults; brainstem gliomas; diffuse intrinsic pontine gliomas; magnetic resonance spectroscopy; pathology