Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma.
A high-throughput phenotypic screen in glioblastoma stem-like cells (GSCs) identified a novel molecular mechanism in which ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) plays an important role in balancing the pool of nucleotides, thus maintaining GSCs in an undifferentiated proliferative state. This finding highlights the connection between cell cycle length and the stem-like tumor state.
The Gurdon Institute and Department of Physiology; Development and Neuroscience; University of Cambridge ; Tennis Court Road , Cambridge, UK.
Josephine
J
Bageritz
Division of Molecular Genetics; German Cancer Research Center ; Heidelberg, Germany.
Violaine
V
Goidts
ENPP1; cell cycle; differentiation; glioblastoma stem-like cells; high-throughput screen; phosphatase