Dynamic variation of histone H3 trimethyl Lys4 (H3K4me3) and heterochromatin protein 1 (HP1) with employment length in nickel smelting workers.
OBJECTIVE
To investigate the dynamic variation in H3K4me3 and HP1 with employment length in nickel smelting workers.


METHODS
Blood samples were collected from 140 nickel smelting workers and 140 age-matched office workers to test for H3K4me3, and HP1 levels.


RESULTS
H3K4me3 was statistically significantly different (p < 0.05) between the two groups and positively correlated with employment length (rs=0.267). HP1 was not correlated with employment length (p = 0.066) but was significantly different between the two groups.


CONCLUSIONS
Chronic exposure to nickel can induce oxidative damage, and increase H3K4me3 expression and inhibit HP1 expression.
a Center for Cancer Prevent and Treatment, Institute of Epidemiology and Statistics , College of Public Health, Lanzhou University , Lanzhou , Gansu , China.
Yanhong
Y
Zhao
b Center of Medical Laboratory, College of Basic Medicine , Lanzhou University , Lanzhou , Gansu , China.
Ning
N
Cheng
c Cancer Institute and Hospital, Chinese Academy of Medical Sciences , Beijing , China.
Min
M
Dai
d Workers' Hospital of Jinchuan Company, Jinchuan Group Co, Ltd , Jinchang , Gansu , China.
Hongquan
H
Pu
e School of Public Health , Brown University , RI , USA.
Tongzhang
T
Zheng
d Workers' Hospital of Jinchuan Company, Jinchuan Group Co, Ltd , Jinchang , Gansu , China.
Haiyan
H
Li
c Cancer Institute and Hospital, Chinese Academy of Medical Sciences , Beijing , China.
Jie
J
He
a Center for Cancer Prevent and Treatment, Institute of Epidemiology and Statistics , College of Public Health, Lanzhou University , Lanzhou , Gansu , China.
Yana
Y
Bai
D000328:Adult; D016022:Case-Control Studies; D000090266:Chromobox Protein Homolog 5; D002868:Chromosomal Proteins, Non-Histone / Q000097:blood; D006657:Histones / Q000097:blood; D006801:Humans; D008669:Metallurgy; D009532:Nickel / Q000494:pharmacology* / Q000652:urine; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis; D018384:Oxidative Stress / Q000187:drug effects; D013997:Time Factors
D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; C000626468:histone H3 trimethyl Lys4; D000090266:Chromobox Protein Homolog 5; D009532:Nickel
H3K4me3; HP1; Nickel smelting workers; biomarkers; oxidative damage