Longterm Retention Rate and Risk Factors for Adalimumab Discontinuation Due To Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis: An Observational Cohort Study.
To evaluate the rates of retention and discontinuation of adalimumab (ADA) due to efficacy and safety in Japanese patients with rheumatoid arthritis (RA).



All patients with RA (n = 476) who were treated with ADA in the Tsurumai Biologics Communication Registry were enrolled.



The retention rate of ADA was 46% at 5 years. When focusing on insufficient efficacy, previous biologics use and high baseline disease activity were significant risk factors for up to 1 year. Methotrexate (MTX) use was a significantly low risk factor after 1 year of treatment.



Concomitant MTX contributes to the longterm efficacy of ADA therapy.
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Yosuke
Y
Hattori
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Toshihisa
T
Kojima
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Atsushi
A
Kaneko
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Daihei
D
Kida
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Yuji
Y
Hirano
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Takayoshi
T
Fujibayashi
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Kenya
K
Terabe
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Yuichiro
Y
Yabe
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Hiroyuki
H
Miyake
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Takefumi
T
Kato
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Hideki
H
Takagi
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Masatoshi
M
Hayashi
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Takayasu
T
Ito
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Yasuhide
Y
Kanayama
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Takeshi
T
Oguchi
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Nobunori
N
Takahashi
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Hisato
H
Ishikawa
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Koji
K
Funahashi
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan.Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD,
Naoki
N
Ishiguro
D000068879:Adalimumab / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D010352:Patient Dropouts; D012042:Registries; D012307:Risk Factors; D016896:Treatment Outcome
D018501:Antirheumatic Agents; D000068879:Adalimumab; D008727:Methotrexate
ADALIMUMAB; DISCONTINUATION; EFFICACY; RETENTION RATE; RHEUMATOID ARTHRITIS; SAFETY