Prognostic significance of CD44 in human colon cancer and gastric cancer: Evidence from bioinformatic analyses.
CD44 is a well-recognized stem cell biomarker expressed in colon and gastric cancer. In order to identify whether CD44 mRNA could be used as a prognostic marker in colon and gastric cancer, bioinformatic analyses were used in this study. cBioPortal analysis and COSMIC analysis were used to explore the CD44 mutation. CD44 mRNA levels were evaluated by using SAGE Genie tools and Oncomine analysis. Kaplan-Meier Plotter was performed to identify the prognostic roles of CD44 mRNA in these two cancers. In this study, first, we found that low alteration frequency of CD44 mRNA in colon and gastric cancer. Second, the high CD44 mRNA level was found in colon and gastric cancer, and it correlated with a benign survival rate in gastric cancer. Third, CD4 and CD74 may be used as markers to predict the prognosis of colon and gastric cancer. However, the deep mechanism(s) of these results remains unclear, further studies have to be performed in the future.
Department of Cell Biology, College of Basic Medical Science, Liaoning Medical University, Jinzhou, Liaoning, P.R. China.
Pu
P
Xia
Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, Liaoning, P.R. China.
Xiao-Yan
XY
Xu
D000230:Adenocarcinoma / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D003110:Colonic Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D019295:Computational Biology; D004252:DNA Mutational Analysis; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics*; D053208:Kaplan-Meier Estimate; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis; D013274:Stomach Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology*
D014408:Biomarkers, Tumor; C497483:CD44 protein, human; D018960:Hyaluronan Receptors; D012333:RNA, Messenger
CD44; The Cancer Genome Atlas; bioinformatic analyses; colon cancer; gastric cancer