[Progress on Correlation between the Expression of CDK5 and Brain Injury Time].
Cyclin-dependent kinase 5 (CDK5) is a member of cyclin-dependent kinase family, which does not directly regulate cell cycle. Through phosphorylation of target protein, CDK5 plays an irreplaceable role in the development, reparation and degeneration of neurons. Brain injury refers to the organic injury of brain tissue caused by external force hit on the head. Owing to the stress and repair system activated by our body itself after injury, various proteins and enzymes of the brain tissues are changed quantitatively, which can be used as indicators for estimating the time of injury. This review summarizes the progress on the distribution, the activity mechanism and the physiological effects of CDK5 after brain injury and its corresponding potential served as a marker for brain injury determination.
Shi-yu
SY
Ma
Ru-bo
RB
Li
Luo Yu-jia
Meng-yan
MY
Lü
Han-zhi
HZ
Wang
Zheng-yin
ZY
Wang
D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D001930:Brain Injuries / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D051360:Cyclin-Dependent Kinase 5 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010766:Phosphorylation / Q000187:drug effects; D013997:Time Factors
D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D051360:Cyclin-Dependent Kinase 5; C495905:CDK5 protein, human