Porous Matrix Stiffness Modulates Response to Targeted Therapy in Breast Carcinoma.
Porous matrix stiffness modulates response to targeted therapy. Poroelastic behavior within porous matrix may modulate the molecule events in cell-matrix and cell-cell interaction like the complex formation of human epidermal growth factor receptor-2 (HER2)-Src-α6β4 integrin, influencing the targeted therapy with lapatinib.
National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.
Cuiying
C
Liu
National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.
Xiang
X
Li
National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.
Wenda
W
Hua
National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.
Jianjun
J
Li
National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.
Xinxiao
X
Han
National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.
Qing
Q
Ha
National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.
Jiantao
J
Feng
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, P. R. China.
Fulong
F
Liao
Institute of Biomedical Engineering, Capital Medical University, Beijing, 100069, P. R. China. ldg213@ccmu.edu.cn.
Dongguo
D
Li
National Center for Nanoscience and Technology, Beijing, 100190, P. R. China. dhan@nanoctr.cn.
Dong
D
Han
D000180:Acrylic Resins / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000494:pharmacology; D039663:Integrin beta4 / Q000378:metabolism; D000077341:Lapatinib; D058990:Molecular Targeted Therapy; D016062:Porosity; D011799:Quinazolines / Q000494:pharmacology / Q000627:therapeutic use; D018719:Erb-b2 Receptor Tyrosine Kinases; D000099166:Polyacrylamides
D000180:Acrylic Resins; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D039663:Integrin beta4; D000077341:Lapatinib; D011799:Quinazolines; D018719:Erb-b2 Receptor Tyrosine Kinases; D000099166:Polyacrylamides; C508053:ERBB2 protein, human
biomechanopharmacology; human epidermal growth factor receptor-2; porous matrix; stiffness; targeted therapy