RANKL/Osteoprotegerin System and Bone Turnover in Hashimoto Thyroiditis.
Hypothyroidism is associated with changes in bone metabolism. The impact of hypothyroidism and the associated autoimmunity on the mediators of bone turnover in Hashimoto's thyroiditis (HT) is not known. In this study, we assessed the levels of OPG, RANKL, and IL-6 along with markers of bone formation as osteocalcin (OC) and markers of bone resorption as type 1 collagen C telopeptide (CTX) and tartrate-resistant acid phosphatase isoform 5b (TRAcP 5b) in 30 hypothyroid and 30 euthyroid premenopausal HT patients and 20 healthy premenopausal controls. We found that TRAcP 5b (p = 0.006), CTX (p = 0.01), OC (p = 0.017), and IL-6 (p < 0.001) levels were lower in the hypothyroid group compared to euthyroid HT patients and controls. OPG levels were higher (p < 0.001) and RANKL levels were lower (p = 0.021) in hypothyroid and euthyroid HT patients compared to controls. TSH was negatively correlated with IL-6 (rho = -0.434, p < 0.001), OC (rho = -0.313, p = 0.006), TRAcP 5b (rho = -0.335, p = 0.003), and positively correlated with OPG (rho = 0.248, p = 0.029). RANKL/OPG ratio was independently associated with the presence of HT. In conclusion, bone turnover is slowed down by hypothyroidism in premenopausal patients with HT. Thyroid autoimmunity might have a unique impact on OPG/RANKL levels apart from the resultant hypothyroidism.
Department of Endocrinology and Metabolism, Endokrinoloji ve Metabolizma BD, Gazi University Faculty of Medicine, Gazi Üniversitesi Hastanesi, 06100, Beşevler, Ankara, Turkey. ceylakonca@yahoo.com.
Ceyla
0000-0003-0299-6596
C
Konca Degertekin
Department of Endocrinology and Metabolism, Endokrinoloji ve Metabolizma BD, Gazi University Faculty of Medicine, Gazi Üniversitesi Hastanesi, 06100, Beşevler, Ankara, Turkey.
Ozlem
O
Turhan Iyidir
Department of Endocrinology and Metabolism, Endokrinoloji ve Metabolizma BD, Gazi University Faculty of Medicine, Gazi Üniversitesi Hastanesi, 06100, Beşevler, Ankara, Turkey.
Banu
B
Aktas Yılmaz
Department of Biochemistry, Biyokimya AD, Gazi University Faculty of Medicine, Gazi Üniversitesi Hastanesi, 06100, Beşevler, Ankara, Turkey.
Sehri
S
Elbeg
Department of Biochemistry, Biyokimya AD, Gazi University Faculty of Medicine, Gazi Üniversitesi Hastanesi, 06100, Beşevler, Ankara, Turkey.
Ozge Tugce
OT
Pasaoglu
Department of Biochemistry, Biyokimya AD, Gazi University Faculty of Medicine, Gazi Üniversitesi Hastanesi, 06100, Beşevler, Ankara, Turkey.
Hatice
H
Pasaoglu
Department of Endocrinology and Metabolism, Endokrinoloji ve Metabolizma BD, Gazi University Faculty of Medicine, Gazi Üniversitesi Hastanesi, 06100, Beşevler, Ankara, Turkey.
Nuri
N
Cakır
Department of Endocrinology and Metabolism, Endokrinoloji ve Metabolizma BD, Gazi University Faculty of Medicine, Gazi Üniversitesi Hastanesi, 06100, Beşevler, Ankara, Turkey.
Metin
M
Arslan
D000328:Adult; D015551:Autoimmunity; D015992:Body Mass Index; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism; D024042:Collagen Type I / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D050031:Hashimoto Disease / Q000097:blood / Q000276:immunology*; D006801:Humans; D007037:Hypothyroidism / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism*; D008875:Middle Aged; D053244:Osteoprotegerin / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism; D017697:Premenopause; D053245:RANK Ligand / Q000378:metabolism*; D012307:Risk Factors; D000071681:Tartrate-Resistant Acid Phosphatase / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism; D014463:Ultrasonography
D024042:Collagen Type I; C508600:IL6 protein, human; D015850:Interleukin-6; D053244:Osteoprotegerin; D010455:Peptides; D053245:RANK Ligand; C506030:TNFRSF11B protein, human; C505688:TNFSF11 protein, human; C052929:collagen type I trimeric cross-linked peptide; C000605510:ACP5 protein, human; D000071681:Tartrate-Resistant Acid Phosphatase
Bone turnover; Hypothyroidism; Osteoprotegerin; RANKL; Thyroiditis