Phase-field model for collective cell migration.
We construct a phase-field model for collective cell migration based on a Ginzburg-Landau free-energy formulation. We model adhesion, surface tension, repulsion, coattraction, and polarization, enabling us to follow the cells' morphologies and the effect of their membranes fluctuations on collective motion. We were able to measure the tissue surface tension as a function of the individual cell cortical tension and adhesion and identify a density threshold for cell-sheet formation.
Graduate Aerospace Laboratories (GALCIT), California Institute of Technology, Pasadena, California 91125, USA.
Sara
S
Najem
Physics Department, Rutherford Building, 3600 rue University, McGill University, Montréal, Québec, Canada H3A 2T8.
Martin
M
Grant
D002448:Cell Adhesion; D002465:Cell Movement; D008954:Models, Biological