Quantitative methods for studying hemostasis in zebrafish larvae.
Hemostasis is a coordinated system through which blood is prevented from exiting a closed circulatory system. We have taken advantage of the zebrafish, an emerging model for the study of blood coagulation, and describe three techniques for quantitative analysis of primary and secondary hemostasis. Collectively, these three techniques comprise a toolset to aid in our understanding of hemostasis and pathological clotting.
University of Michigan, Ann Arbor, MI, United States.
M S
MS
Rost
University of Michigan, Ann Arbor, MI, United States.
S J
SJ
Grzegorski
University of Michigan, Ann Arbor, MI, United States.
J A
JA
Shavit
D000818:Animals; D001777:Blood Coagulation / Q000235:genetics*; D006487:Hemostasis / Q000235:genetics*; D006801:Humans; D007814:Larva / Q000235:genetics / Q000502:physiology; D013927:Thrombosis / Q000235:genetics* / Q000503:physiopathology; D015027:Zebrafish / Q000235:genetics / Q000502:physiology
Clotting; Coagulation; Fibrinogen; Hematology; Hemostasis; Thrombosis; Zebrafish