Symmetry breaking in human neuroblastoma cells.
Asymmetric cell division (ACD) is a characteristic of cancer stem cells, which exhibit high malignant potential. However, the cellular mechanisms that regulate symmetric (self-renewal) and asymmetric cell divisions are mostly unknown. Using human neuroblastoma cells, we found that the oncosuppressor protein tripartite motif containing 32 (TRIM32) positively regulates ACD.
Division of Cancer Therapeutics; Research Institute for Clinical Oncology; Saitama Cancer Center ; Saitama, Japan.
Hideki
H
Izumi
Division of Cancer Therapeutics; Research Institute for Clinical Oncology; Saitama Cancer Center ; Saitama, Japan.
Yasuhiko
Y
Kaneko
MYCN; TRIM32; asymmetric cell division; cancer stem cells