Aquaporins in Urinary Extracellular Vesicles (Exosomes).
Since the successful characterization of urinary extracellular vesicles (uEVs) by Knepper's group in 2004, these vesicles have been a focus of intense basic and translational research worldwide, with the aim of developing novel biomarkers and therapeutics for renal disease. Along with these studies, there is growing evidence that aquaporins (AQPs), water channel proteins, in uEVs have the potential to be diagnostically useful. In this review, we highlight current knowledge of AQPs in uEVs from their discovery to clinical application.
Department of Veterinary Pharmacology, University of Miyazaki, Miyazaki 889-2192, Japan. oshikawa.sayaka.g3@cc.miyazaki-u.ac.jp.
Sayaka
S
Oshikawa
Department of Veterinary Pharmacology, University of Miyazaki, Miyazaki 889-2192, Japan. sonoda-h@cc.miyazaki-u.ac.jp.
Hiroko
H
Sonoda
Department of Veterinary Pharmacology, University of Miyazaki, Miyazaki 889-2192, Japan. a0d302u@cc.miyazaki-u.ac.jp.
Masahiro
M
Ikeda
D020346:Aquaporins / Q000378:metabolism / Q000652:urine*; D015415:Biomarkers / Q000378:metabolism / Q000652:urine; D055354:Exosomes / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism / Q000652:urine*
D020346:Aquaporins; D015415:Biomarkers
aquaporin-1; aquaporin-2; exosomes; extracellular vesicles; kidney; urine