ERCC2 rs13181 polymorphism association with glioma susceptibility in a Chinese population.
We conducted a case-control study to investigate the role of ERCC2 rs13181 polymorphism in glioma development. A total of 165 patients who were histopathologically diagnosed to have gliomas and 330 controls were collected at Jiujiang First People's Hospital between July 2012 and June 2014. The ERCC2 rs13181 polymorphism was analyzed using a polymerase chain reaction -restriction fragment length polymorphism assay. By conditional regression analysis, we found that the GG genotype of the ERCC2 rs13181 polymorphism is associated with susceptibility to gliomas when compared to the TT genotype (OR = 2.05, 95%CI = 1.11-3.79). In the recessive model, the GG genotype is associated with an increased risk of gliomas when compared with the TT+TG genotype (OR = 1.87, 95%CI = 1.03-3.37). In conclusion, the ERCC2 rs13181 polymorphism is correlated with an increased risk of gliomas in codominant and recessive models, which suggests that this polymorphism could influence the etiology of gliomas.
Department of Neurosurgery, Nanfang Hospital, Southern Medical University Guangzhou, China.|Department of Neurosurgery, Jiujiang First People's Hospital, Jiujiang, China.
X
X
Gao
Department of Neurosurgery, Jiujiang First People's Hospital, Jiujiang, China.
Y J
YJ
Tang
Department of Neurosurgery, Jiujiang First People's Hospital, Jiujiang, China.
G F
GF
Zhang
Department of Neurosurgery, Nanfang Hospital, Southern Medical University Guangzhou, China.
L
L
Yu
Department of Neurosurgery, Nanfang Hospital, Southern Medical University Guangzhou, China.
S T
ST
Qi
D000328:Adult; D000368:Aged; D044466:Asian People; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human