The Interactions of CPP-ACP with Saliva.
The repair of early dental caries lesions has been demonstrated by the application of the remineralisation technology based on casein phosphopeptide-stabilised amorphous calcium phosphate complexes (CPP-ACP). These complexes consist of an amorphous calcium phosphate mineral phase stabilised and encapsulated by the self-assembly of milk-derived phosphopeptides. During topical application of CPP-ACP complexes in the oral cavity, the CPP encounters the enamel pellicle consisting of salivary proteins and peptides. However the interactions of the CPP with the enamel salivary pellicle are not known. The studies presented here reveal that the predominant peptides of CPP-ACP complexes do interact with specific salivary proteins and peptides of the enamel pellicle, and provide a mechanism by which the CPP-ACP complexes are localised at the tooth surface to promote remineralisation.
Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Melbourne 3010, Australia. laila@unimelb.edu.au.
Noorjahan Laila
NL
Huq
Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Melbourne 3010, Australia. helen_myroforidis@hotmail.com.
Helen
H
Myroforidis
Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Melbourne 3010, Australia. keith.cross@unimelb.edu.au.
Keith J
KJ
Cross
Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Melbourne 3010, Australia. dstanton@unimelb.edu.au.
David P
DP
Stanton
Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Melbourne 3010, Australia. pdv@unimelb.edu.au.
Paul D
PD
Veith
Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Melbourne 3010, Australia. brentrw@unimelb.edu.au.
Brent R
BR
Ward
Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, 720 Swanston Street, Melbourne 3010, Australia. e.reynolds@unimelb.edu.au.
Eric C
EC
Reynolds
D002364:Caseins / Q000009:adverse effects / Q000494:pharmacology*; D044622:Dental Pellicle / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D011485:Protein Binding; D012463:Saliva / Q000187:drug effects* / Q000378:metabolism; D012471:Salivary Proteins and Peptides / Q000378:metabolism
D002364:Caseins; D012471:Salivary Proteins and Peptides; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex
casein phosphopeptide; enamel; pellicle; saliva