Tetrahydroxanthones from Mongolian medicinal plant Gentianella amarella ssp. acuta.
Two tetrahydroxanthones, 1,3,5S,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (1) and 1,3,5R,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (2), and six new tetrahydroxanthone glycosides, amarellins A-F (3-8), were isolated from the aerial parts of a Mongolian medicinal plant Gentianella amarella ssp. acuta (Gentianaceae). The structures of 1-8 were elucidated on the basis of spectroscopic analysis, chemical conversion, and ECD calculation. Amarellins A-C (3-5) were assigned as 8-O-β-D-glucoside, 8-O-β-D-xyloside, and 1-O-β-D-glucoside of 1, respectively, while amarellins D-F (6-8) were elucidated to be 8-O-β-D-xyloside, 1-O-β-D-glucoside, and 3-O-β-D-glucoside of 2, respectively.
Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.
Shuangxin
S
Lu
Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.|Graduate School of Bioscience and Bioindustry, Tokushima University, Tokushima, 770-8513, Japan.
Naonobu
N
Tanaka
Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan.
Kazuyoshi
K
Kawazoe
Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, 862-0082, Japan.
Kotaro
K
Murakami
School of Pharmaceutical Biomedical Sciences, Mongolian National University of Medical Sciences, Ulaanbaatar, 14210, Mongolia.
Davaadagva
D
Damdinjav
School of Pharmaceutical Biomedical Sciences, Mongolian National University of Medical Sciences, Ulaanbaatar, 14210, Mongolia.
Enkhjargal
E
Dorjbal
Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan. kasiwada@tokushima-u.ac.jp.
Yoshiki
Y
Kashiwada
D029965:Gentianaceae / Q000737:chemistry; D031313:Gentianella / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D008986:Mongolia; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification*
D005960:Glucosides; D006027:Glycosides; D010936:Plant Extracts; D044004:Xanthones; C010807:xylosides
Amarellins A–F; Gentianaceae; Gentianella amarella ssp. acuta; Tetrahydroxanthone