Association between IGF2BP2 Polymorphisms and Type 2 Diabetes Mellitus: A Case-Control Study and Meta-Analysis.
Genome-wide association studies (GWAS) found that IGF2BP2 rs4402960 and rs1470579 polymorphisms were associated with type 2 diabetes mellitus (T2DM) risk. Many studies have replicated this association, but yielded inconsistent results.



A case-control study consisting of 461 T2DM patients and 434 health controls was conducted to detect the genetic susceptibility of IGF2BP2 in a northern Han Chinese population. A meta-analysis was to evaluate the association more precisely in Asians.



In the case-control study, the carriers of TT genotype at rs4402960 had a higher T2DM risk than the G carriers (TG + GG) (adjusted odd ratio (AOR) = 1.962, 95% confidence interval (95% CI) = 1.065-3.612, p = 0.031]; CC carriers at rs1470579 were more susceptible to T2DM than A carriers (CA + AA) (AOR = 2.014, 95% CI = 1.114-3.642, p = 0.021). The meta-analysis containing 36 studies demonstrated that the two polymorphisms were associated with T2DM under the allele comparison, genetic models of dominant and recessive in Asians (p < 0.05). The rs4402960 polymorphisms were significantly associated with the T2DM risk after stratification by diagnostic criterion, size of sample and average age and BMI of cases, while there're no consistent results for rs1470579.



Our data suggests that IGF2BP2 polymorphisms are associated with T2DM in Asian populations.
School of Public Health, Capital Medical University, Beijing 100069, China. raopingbj@126.com.
Ping
P
Rao
School of Public Health, Capital Medical University, Beijing 100069, China. wanghaostudy@163.com.
Hao
H
Wang
School of Public Health, Capital Medical University, Beijing 100069, China. fanghonghong79@sina.com.
Honghong
H
Fang
School of Public Health, Capital Medical University, Beijing 100069, China. shouyigaoqing@163.com.
Qing
Q
Gao
School of Public Health, Capital Medical University, Beijing 100069, China. zhangjie@ccmu.edu.cn.
Jie
J
Zhang
School of Public Health, Capital Medical University, Beijing 100069, China. songms@ccmu.edu.cn.
Manshu
M
Song
Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. yongzhou78214@163.com.
Yong
Y
Zhou
School of Public Health, Capital Medical University, Beijing 100069, China. wangy@ccmu.edu.cn.
Youxin
Y
Wang
School of Public Health, Capital Medical University, Beijing 100069, China. wei.wang@ecu.edu.au.|School of Medical Sciences, Edith Cowan University, Perth, WA 6027, Australia. wei.wang@ecu.edu.au.
Wei
W
Wang
D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D016601:RNA-Binding Proteins / Q000235:genetics*; D012306:Risk
C498779:IGF2BP2 protein, human; D016601:RNA-Binding Proteins
Asian; IGF2BP2; case-control study; meta-analysis; type 2 diabetes mellitus