High Concordance between Self-Reported Adherence, Treatment Outcome and Satisfaction with Care Using a Nine-Item Health Questionnaire in InfCareHIV.
BACKGROUND
In this cross-sectional study we present an integrated analysis of a self-reported Health Questionnaire and socio-demographic and treatment outcome data from the national Swedish HIV cohort, InfCareHIV.


OBJECTIVE
To evaluate the Health Questionnaire and identify the main determinants of adherence.


METHODS
A total of 2,846 patients answered a nine-item disease-specific Health Questionnaire between 2012 and 2014, corresponding to 44% of all active patients in the national InfCareHIV cohort. The questionnaire assessed patient related outcome measures (PROMs) regarding health and antiretroviral treatment (ART) and patient related experience measures (PREMs) regarding involvement in care and satisfaction with the care provider.


RESULTS
We found the Health Questionnaire to be valid and reliable when used in ordinary clinical practice. There was a high concordance between self-reported adherence to ART in the past seven days and treatment outcome, with 94% of patients who reported optimal adherence having a viral load <50 copies/ml. The main determinants of optimal adherence were heterosexual transmission path, being born in Sweden, being male, not reporting experience of ART side effects and being fully satisfied with care.


CONCLUSIONS
The nine-item Health Questionnaire can identify patients at risk of treatment failure, those in need of clinical assessment of adverse events and those with impaired physical health.
Department of Infectious Diseases and Clinical Virology, Karolinska University Hospital, Stockholm, Sweden.|Department of Public Health Sciences, Karolinska Institutet, Solna, Sweden.
Gaetano
G
Marrone
Clinic of Infectious Diseases, South Älvsborg Hospital, Borås, Sweden.
Åsa
Å
Mellgren
Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Solna, Sweden.|Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.|School of Health Sciences, City University London, London, United Kingdom.
Lars E
LE
Eriksson
Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.|Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Veronica
V
Svedhem
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology; D008875:Middle Aged; D010549:Personal Satisfaction; D011788:Quality of Life / Q000523:psychology*; D057566:Self Report; D011795:Surveys and Questionnaires; D013548:Sweden; D016896:Treatment Outcome; D019562:Viral Load / Q000187:drug effects*; D016903:Drug Monitoring
D019380:Anti-HIV Agents