Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes.
The different mechanisms employed by proto-oncogenes and tumor suppressors to regulate cell death pathways are strictly linked to their localization. In addition to the canonical control of apoptosis at a transcriptional/nuclear level, intracellular zones are emerging as pivotal sites for the activities of several proapoptotic and antiapoptotic factors. Here, we review the function of the endoplasmic reticulum-mitochondria interface as a primary platform for decoding danger signals as well as a structural accommodation for several regulator or effector proteins.
Department of Morphology; Surgery and Experimental Medicine ; Section of Pathology; Oncology and Experimental Biology and LTTA Center ; University of Ferrara ; Ferrara, Italy.
Saverio
S
Marchi
Department of Morphology; Surgery and Experimental Medicine ; Section of Pathology; Oncology and Experimental Biology and LTTA Center ; University of Ferrara ; Ferrara, Italy.
Carlotta
C
Giorgi
Department of Biochemistry; Nencki Institute of Experimental Biology ; Warsaw, Poland.
Monika
M
Oparka
Department of Biochemistry; Nencki Institute of Experimental Biology ; Warsaw, Poland.
Jerzy
J
Duszynski
Department of Biochemistry; Nencki Institute of Experimental Biology ; Warsaw, Poland.
Mariusz R
MR
Wieckowski
Department of Morphology; Surgery and Experimental Medicine ; Section of Pathology; Oncology and Experimental Biology and LTTA Center ; University of Ferrara ; Ferrara, Italy.
Paolo
P
Pinton
apoptosis; calcium; cancer; endoplasmic reticulum; mitochondria; mitochondria-associated membranes (MAMs); oncogenes; oncosuppressors