The second hit of DNA methylation.
Gene expression programs are tightly regulated by heritable "epigenetic" information, which is stored as chemical modifications of histones and DNA. With the recent development of sequencing-based epigenome mapping technologies and cancer cellular reprogramming, the tools are now in hand to analyze the epigenetic contribution to human cancer.
Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Boston, MA, USA; Department of Translational Medicine, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.
Annalisa
A
Di Ruscio
Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Boston, MA, USA.
Robert S
RS
Welner
Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Boston, MA, USA; Cancer Science Institute, National University of Singapore, Singapore.
Daniel G
DG
Tenen
Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Boston, MA, USA; ADIENNE, Lugano, Switzerland.
Giovanni
G
Amabile