Ewing sarcoma/primitive neuroectodermal tumor of the kidney treated with chemotherapy including ifosfamide.
Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) of the kidney is extremely rare, and is usually diagnosed after nephrectomy without neoadjuvant chemotherapy. Although ifosfamide and etoposide improve survival to a great extent in ES/PNET, the use of nephrotoxic agent, particularly ifosfamide, is a concern after nephrectomy. We describe the case of a 14-year-old female patient with abdominal mass who was diagnosed with ES/PNET of the right kidney after nephrectomy. Adjuvant chemotherapy including ifosfamide and etoposide were given. The estimated glomerular filtration rate decreased to 75% after the end of therapy. There was no evidence of recurrence 70 months after initial diagnosis.
Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
Hiroki
H
Yoshihara
Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
Takahiro
T
Kamiya
Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
Yosuke
Y
Hosoya
Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
Daisuke
D
Hasegawa
Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
Chitose
C
Ogawa
Department of Urology, Keio University School of Medicine, Tokyo, Japan.
Hiroshi
H
Asanuma
Department of Urology, Keio University School of Medicine, Tokyo, Japan.
Ryuichi
R
Mizuno
Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
Ryota
R
Hosoya
Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan.
Atsushi
A
Manabe
D000293:Adolescent; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D018242:Neuroectodermal Tumors, Primitive; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide
Ewing sarcoma; drug toxicity; ifosfamide; primitive neuroectodermal tumor; renal tumor