An overlooked tumor promoting immunoregulation by non-hematopoietic stromal cells.
Multidirectional complex communication between tumor-residing hematopoietic and non-hematopoietic stromal cells (NHSCs) decisively regulates cancer development, progression and therapeutic responses. HSCs predominantly participate in the immune regulations, while, NHSCs, provide parenchymal support or serve as a conduit for other cells or support angiogenesis. However, recent reports suggest NHSCs can additionally participate in ongoing tumor promoting immune reactions within tumor-microenvironment (TME). In this review, based on the state-of-art knowledge and accumulated evidence by us, we discuss the role of quite a few NHSCs in tumor from immunological perspectives. Understanding such consequence of NHSCs will surely pave the way in crafting effective cancer management.
Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37, S.P. Mukherjee Road, Kolkata 700026, India. Electronic address: anamikabose2@gmail.com.
Anamika
A
Bose
Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37, S.P. Mukherjee Road, Kolkata 700026, India.
Tithi
T
Ghosh
Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37, S.P. Mukherjee Road, Kolkata 700026, India.
Rathindranath
R
Baral
D017667:Adipocytes / Q000276:immunology*; D000818:Animals; D063646:Carcinogenesis; D042783:Endothelial Cells / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology*; D005347:Fibroblasts / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D009389:Neovascularization, Pathologic; D020286:Pericytes / Q000276:immunology*; D019139:Tumor Escape; D059016:Tumor Microenvironment
Fibroblasts; Immunoregulation; Non-hematopoietic stromal cells; Pericytes; Tumor microenvironment