Circulating Endothelial Microparticles and Correlation of Serum 1,25-Dihydroxyvitamin D with Adiponectin, Nonesterified Fatty Acids, and Glycerol from Middle-Aged Men in China.
The aim of the present study is (1) to determine the correlation between circulating 1,25-dihydroxyvitamin D [25(OH)D] and adiponectin, nonesterified fatty acids (NEFAs), and glycerol and (2) to determine the alterations in circulating endothelial microparticles (EMPs) in Chinese male subjects with increased body mass index (BMI). A total of 45 male adults were enrolled with varied BMI [i.e., lean, overweight (OW), and obese (OB), N = 15 per group]. Blood samples were collected under overnight fasting condition, and plasma was isolated for the measurement of endothelial microparticles (EMPs), total and high-molecular weight (HMW) adiponectin, 25(OH)D, nonesterified fatty acids (NEFAs), and glycerol. Circulating 25(OH)D levels were inversely associated with total adiponectin, NEFA, and glycerol levels. There is no difference for CD62E+ or CD31+/CD42b- EMPs among 3 groups. In Chinese male adults with varied BMI, an inverse correlation existed between 25(OH)D levels and total adiponectin, NEFA, and glycerol levels; and there is no significant difference for CD62E+ or CD31+/CD42b- EMPs among lean, overweight, and obese subjects.
Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou 215123, China; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Disease, Soochow University, 199 Renai Road, Suzhou 215123, China.
Zhongxiao
Z
Wan
Suzhou Industrial Park center Disease Control & Prevention, 58 Suqian Road, Suzhou 215123, China.
Lugang
L
Yu
Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou 215123, China.
Jinbo
J
Cheng
Department of Labor Hygiene and Environmental Health, School of Public Health, Soochow University, 199 Renai Road, Suzhou 215123, China.
Zengli
Z
Zhang
Suzhou Industrial Park center Disease Control & Prevention, 58 Suqian Road, Suzhou 215123, China.
Baohui
B
Xu
Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou 215123, China; Suzhou Industrial Park center Disease Control & Prevention, 58 Suqian Road, Suzhou 215123, China.
Xing
X
Pang
Suzhou Industrial Park center Disease Control & Prevention, 58 Suqian Road, Suzhou 215123, China.
Hui
H
Zhou
Suzhou Industrial Park center Disease Control & Prevention, 58 Suqian Road, Suzhou 215123, China.
Ting
T
Lei
D052242:Adiponectin / Q000097:blood*; D055252:Cell-Derived Microparticles / Q000473:pathology; D002681:China; D042783:Endothelial Cells / Q000473:pathology; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005990:Glycerol / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D050177:Overweight / Q000097:blood; D013851:Thinness / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
C499918:ADIPOQ protein, human; D052242:Adiponectin; D005230:Fatty Acids, Nonesterified; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D005990:Glycerol