Novel role of p73 as a regulator of developmental angiogenesis: Implication for cancer therapy.
Information regarding the role of p73 in the regulation of angiogenesis has been incomplete and quite controversial. Remarkably, several groups, including ours, have recently demonstrated that TP73 plays a fundamental role in angiogenesis regulation and that differential expression of TP73 could have important consequences in tumor angiogenesis. Here, we discuss a possible model for p73 function in the regulation of developmental angiogenesis and tumor angiogenesis.
Instituto de Biomedicina and Departmento de Biologia Molecular; University of Leon ; Leon, Spain.
Maria C
MC
Marin
Instituto de Desarrollo Ganadero; University of Leon ; Leon, Spain.
Margarita M
MM
Marques
TGF-β; angiogenesis; endothelial cell differentiation; endothelial cell migration; induced pluripotent stem cells; mouse embryonic stem cells; p73; vasculogenesis