Pro-survival role of p62 during granulocytic differentiation of acute myeloid leukemia cells.
p62 regulates key signaling pathways including those that control cell death and autophagy. Recently, we reported that p62 is upregulated during all-trans retinoic acid (ATRA)-induced terminal differentiation of acute myeloid leukemia (AML) cells. This response reduces levels of ubiquitinated protein aggregates in mature cells and protects these cells against ATRA treatment. Thus, p62 confers a survival advantage to mature AML cells.
INSERM UMR-S 1007; Cellular Homeostasis and Cancer; Université Paris Descartes; Sorbonne Paris Cite ; Paris, France.
Evelyne
E
Ségal-Bendirdjian
Division of Experimental Pathology; Institute of Pathology; University of Bern ; Bern, Switzerland.
Mario P
MP
Tschan
INSERM U916 VINCO; Institut Bergonié; Bordeaux, France; University of Bordeaux; Bordeaux, France.
Josy
J
Reiffers
INSERM U916 VINCO; Institut Bergonié; Bordeaux, France; University of Bordeaux; Bordeaux, France.
Mojgan
M
Djavaheri-Mergny
SQSTM1/p62; autophagy; cell survival; differentiation; leukemia