[Clinical Phenomenology of Autoimmune Encephalitis].
Antibody-associated disorders of the central nervous system constitute a heterogeneous group of disorders that can be roughly divided into two categories: Classic paraneoplastic syndromes associated with so-called well-characterized antibodies (paraneoplastic neurological disorders, PND) and autoimmune disorders with antibodies to membrane-bound or synaptic antigens (autoimmune encephalitis, AE). The discovery of autoimmune encephalitis has led to a paradigm shift in diagnosis and therapy as well as a reclassification of some neuropsychiatric syndromes that were previously classified as idiopathic or simply covered with descriptive terms.In this review article, especially clinical aspects of autoimmune encephalitis will be discussed, as there has been a rapid increase in knowledge in this regard within the past decade; increasingly overlap syndromes and associations with other disease entities have been detected. In addition to general aspects, characteristics of anti-NMDAR-, anti-LGI1-, anti-GABAA and GABABR, anti-AMPAR-, anti-CASPR2-, anti-mGluR, anti-GlycinR-, anti-GAD, anti- DPPX- and anti-D2 R encephalitis and the anti-IgLON5 encephalopathy will be presented.
Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Köln.
J F
JF
Holle
Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Köln.
F
F
Jessen
Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Köln.
J
J
Kuhn
D000954:Antigens, Surface / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D004660:Encephalitis / Q000175:diagnosis* / Q000276:immunology; D020803:Encephalitis, Herpes Simplex / Q000175:diagnosis / Q000276:immunology; D050031:Hashimoto Disease / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D009474:Neurons / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000276:immunology; D012307:Risk Factors
D000954:Antigens, Surface; D001323:Autoantibodies; D001324:Autoantigens