Cytoplasmic gain-of-function mutant p53 contributes to inflammation-associated cancer.
Inflammation and mutation of the tumor suppressor p53 are two apparently unrelated conditions that are strongly associated with cancer initiation and progression. We recently reported that gain-of-function mutant p53 modifies the response of cancer cells to inflammatory signals by binding a cytoplasmic tumor suppressor protein involved in TNFα signaling.
Laboratorio Nazionale CIB (LNCIB); AREA Science Park; Trieste, Italy; Department of Scienze della Vita; Università degli Studi di Trieste; Trieste, Italy.
Arianna
A
Bellazzo
Institute of Molecular Health Sciences; Swiss Federal Institute of Technology; ETH Hönggerberg ; Zurich, Switzerland.
Giulio
G
Di Minin
Laboratorio Nazionale CIB (LNCIB); AREA Science Park; Trieste, Italy; Department of Scienze della Vita; Università degli Studi di Trieste; Trieste, Italy.
Licio
L
Collavin
AIP1; DAB2IP; basal-like breast cancer; cancer cell invasivity; tumor necrosis factor