Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities.
Covering: up to 2016Antimycin-type depsipeptides are a family of natural products with great structural diversity and outstanding biological activities. These compounds have typically been isolated from actinomycetes and are generated from hybrid nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) assembly lines. This review covers the literature on the four classes of antimycin-type depsipeptides, which differ by macrolactone ring size, and it discusses the discovery, biosynthesis, chemical synthesis, and biological activities of this family of compounds.
Department of Bioengineering, University of California, Berkeley, California, USA.
Joyce
J
Liu
Xuejun
X
Zhu
Seong Jong
SJ
Kim
Wenjun
W
Zhang
D000190:Actinomyces / Q000737:chemistry*; D000595:Amino Acid Sequence; D000968:Antimycin A / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D047630:Depsipeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010453:Peptide Synthases / Q000378:metabolism*
D001688:Biological Products; D047630:Depsipeptides; C032456:antimycin; D000968:Antimycin A; D010453:Peptide Synthases; C104385:non-ribosomal peptide synthase