Environmental cues orchestrate regional immune surveillance and protection by pulmonary CTLs.
Tissue-resident memory CD8 T cells (TRM) provide preemptive immunity against infections that begin in peripheral tissues by guarding the site of initial pathogen exposure. Their role in immunity to respiratory virus infection is particularly important because severe damage to the alveoli can be avoided when local populations of TRMcells reduce viral burdens and dampen the responses of effector CD8 T cells in the lungs. Although a connection between rapid immune activation and early viral control is well established, the signals that keep TRMcells poised for action in the local tissues remain poorly defined. Recent studies have shown that environmental cues influence the fate decisions of activated CTLs during memory formation. Manipulation of these signaling pathways could provide new ways to capitalize on protection from TRMcells in mucosal tissues, while reducing collateral damage and pathology during vaccination.
Department of Immunology, University of Connecticut Medical School, UConn Health, Farmington, Connecticut, USA lcauley@uchc.edu.
Linda S
LS
Cauley
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007156:Immunologic Memory; D007157:Immunologic Surveillance; D007251:Influenza, Human / Q000276:immunology; D008168:Lung / Q000276:immunology* / Q000821:virology; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D018448:Models, Immunological; D011024:Pneumonia, Viral / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014611:Vaccination; D014765:Viral Vaccines
D014765:Viral Vaccines
CD8 T cell differentiation; cellular immunity; signaling pathways