Think You Know How Smell Works? Sniff Again.
The sense of smell is mediated by GPCRs in the odorant receptor (OR) family. Greer et al. report a new family of odor detectors, MS4As, that have similar cellular localization and chemodetection ability as ORs but are not GPCRs and follow a strikingly different logic of odor coding at the periphery.
Department of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Sandeepa
S
Dey
Department of Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: stowers@scripps.edu.
Lisa
L
Stowers
D006801:Humans; D009812:Odorants; D018035:Receptors, Odorant; D012677:Sensation; D012903:Smell; D013850:Thinking
D018035:Receptors, Odorant