ATG2B and GSKIP: 2 new genes predisposing to myeloid malignancies.
We have recently identified a 700-kb tandem duplication at locus 14q32.13-q32.2 involving 2 genes, autophagy-related protein 2 homolog B (ATG2B) and GSK3B interacting protein (GSKIP), that increases the predisposition to myeloid malignancies. Here, we discuss the clinical relevance of these findings.
INSERM, UMR 1170, Gustave Roussy, Villejuif, France; Université Paris-Sud, UMR1170, Gustave Roussy, Villejuif, France; Gustave Roussy, Villejuif France.
Isabelle
I
Plo
INSERM, UMR 1170, Gustave Roussy, Villejuif, France; Department of Genetics, AP-HP Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, Paris, France; Université Pierre et Marie Curie, Paris, France UMR U1170, Gustave Roussy, 114 rue Edouard Vaillant, 94805, Villejuif, France.
Christine
C
Bellanné-Chantelot
INSERM, UMR 1170, Gustave Roussy, Villejuif, France; Université Paris-Sud, UMR1170, Gustave Roussy, Villejuif, France; Gustave Roussy, Villejuif France.
William
W
Vainchenker
ATG2B; GSKIP; chromosome 14; leukemia; myeloproliferative neoplasm