Late gestational liver dysfunction and its impact on pregnancy outcomes.
OBJECTIVE
The aim of this study was to investigate the impacts of late gestational liver dysfunction and its impact on pregnancy outcomes.


METHODS
The patients hospitalized for liver dysfunction in their late pregnancy between 2010-2012 were set as the observation group, and the pregnant women with normal liver function at the same period were randomly selected and set as the control group. The impacts towards the pregnancy outcomes were compared between these two groups and the impacts of different-degree transaminase increasing towards the pregnancy outcome were analyzed.


RESULTS
The incidence rates of cesarean section, post-partum hemorrhage, fetal distress, premature birth, premature rupture of membranes (PROM) of the observation group and the transaminase-severely-increased group (the severe group) were higher, and the differences were statistically significant (p < 0.01 or < 0.05); while only the cesarean rate of the mild and moderate group was significantly different from the control group (p < 0.01 or < 0.05). The ratios of intrahepatic cholestasis in pregnancy (ICP), gestational hypertension + HELLP syndrome, acute fatty liver in pregnancy (AFLP) of the severe group were higher than the mild and moderate group, and the differences were statistically significant; the non-alcoholic fatty liver disease (NAFLD) group and the unknown cause group mainly showed a mildly increased transaminase; the distributions of viral hepatitis in pregnancy (VHP), post-viral-hepatitis-B cirrhosis, biliary tract disease, and infected toxic liver dysfunction in different-degree increased transaminase groups had no significant difference.


CONCLUSIONS
Liver dysfunction in later pregnancy, especially with severe transaminase increase, might significantly increase the risk of adverse maternal events. The major causes of severe liver dysfunction in late pregnancy were ICP, gestational hypertensive disorders, and AFLP.
D X
DX
Zhou
X Y
XY
Bian
X Y
XY
Cheng
P
P
Xu
Y F
YF
Zhang
J X
JX
Zhong
H Y
HY
Qian
S
S
Huang
D000328:Adult; D016022:Case-Control Studies; D002585:Cesarean Section / Q000706:statistics & numerical data*; D002681:China / Q000453:epidemiology; D002780:Cholestasis, Intrahepatic / Q000453:epidemiology; D005234:Fatty Liver / Q000453:epidemiology; D005260:Female; D005316:Fetal Distress / Q000453:epidemiology*; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology*; D017359:HELLP Syndrome / Q000453:epidemiology; D006525:Hepatitis, Viral, Human / Q000453:epidemiology; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology; D008107:Liver Diseases / Q000453:epidemiology*; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology; D016017:Odds Ratio; D006473:Postpartum Hemorrhage / Q000453:epidemiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology*; D012720:Severity of Illness Index; D055815:Young Adult