The impact of body weight gain on nonalcoholic fatty liver disease and metabolic syndrome during earlier and later adulthood.
OBJECTIVE
Body weight gain adds risk for metabolic disorders and there are different metabolic changes in earlier and later adulthood. However, its impact on non-alcoholic fatty liver disease (NAFLD) was indeterminate. The aim of current study was to evaluate the impact of body weight gain on NAFLD and metabolic syndrome (MetS) during overall, earlier (25-40y) and later (over 40y) adulthood.


METHODS
1119 subjects were selected to calculate changes in body weight (ΔBW), body mass index (BMI) (ΔBMI) and bodyweight per year (ΔBW/y) to analysis their impact on NAFLD and MetS in multi-variable regression models, and explored the potential mediators that associated ΔBMI with NAFLD by mediation analysis.


RESULTS
ΔBMI, ΔBW and ΔBW/y in whole adulthood were all positively associated with NAFLD and MetS. Body weight gain during earlier adulthood was more strongly associated with NAFLD than those during later adulthood. In NAFLD, the ORs of ΔBMI (third trisection), ΔBW and ΔBW/y were 3.86 (2.25, 6.57), 1.05 (1.02, 1.09) and 2.05 (1.29, 3.24) during earlier adulthood, and 1.47 (1.09, 2.02), 1.02 (1.00, 1.06), and 1.04 (.99, 1.13) over 40y. Insulin and HOMA-IR were important intermediates that associated ΔBMI with NAFLD. ΔBMI in earlier adulthood increased higher insulin and insulin resistance (IR) than later adulthood.


CONCLUSIONS
Body weight gain in adulthood was positively associated with NAFLD and MetS, and the association was stronger in earlier than later adulthood. Insulin and IR were important mediators that contributed to the association.
National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
Shanshan
S
Du
Department of Environmental Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
Cheng
C
Wang
Physical Examination Center, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Wei
W
Jiang
Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Chunlong
C
Li
National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
Yanchuan
Y
Li
National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China. Electronic address: fengrennan@163.com.
Rennan
R
Feng
National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China. Electronic address: changhao2002sun@gmail.com.
Changhao
C
Sun
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications*; D012307:Risk Factors; D015430:Weight Gain
Adulthood; Body weight gain; Insulin; Metabolic syndrome; Non-alcoholic fatty liver disease