[Simultaneous whole-body PET-MRI in pediatric oncology : More than just reducing radiation?].
Diagnostic imaging plays an essential role in pediatric oncology with regard to diagnosis, therapy-planning, and the follow-up of solid tumors. The current imaging standard in pediatric oncology includes a variety of radiological and nuclear medicine imaging modalities depending on the specific tumor entity. The introduction of combined simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) has opened up new diagnostic options in pediatric oncology. This novel modality combines the excellent anatomical accuracy of MRI with the metabolic information of PET. In initial clinical studies, the technical feasibility and possible diagnostic advantages of combined PET-MRI have been in comparison with alternative imaging techniques. It was shown that a reduction in radiation exposure of up to 70 % is achievable compared with PET-CT. Furthermore, it has been shown that the number of imaging studies necessary can be markedly reduced using combined PET-MRI. Owing to its limited availability, combined PET-MRI is currently not used as a routine procedure. However, this new modality has the potential to become the imaging reference standard in pediatric oncology in the future. This review article summarizes the central aspects of pediatric oncological PET-MRI based on existing literature. Typical pediatric oncological PET-MRI cases are also presented.
Radiologische Klinik, Diagnostische und Interventionelle Radiologie, Universität Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Deutschland. sergios.gatidis@med.uni-tuebingen.de.
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Gatidis
Radiologische Klinik, Diagnostische und Interventionelle Radiologie, Universität Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Deutschland.
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Gückel
Radiologische Klinik, Nuklearmedizin, Universität Tübingen, Tübingen, Deutschland.
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la Fougère
Abteilung für Präklinische Bildgebung und Radiopharmazie, Werner Siemens Imaging Center, Universität Tübingen, Tübingen, Deutschland.
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Schmitt
Radiologische Klinik, Diagnostische und Interventionelle Radiologie, Universität Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Deutschland.
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Schäfer
D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D064847:Multimodal Imaging / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging*; D061214:Patient Safety; D049268:Positron-Emission Tomography / Q000379:methods*; D011829:Radiation Dosage; D000069079:Radiation Exposure / Q000032:analysis / Q000517:prevention & control*; D011835:Radiation Protection / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods*
Diagnostic imaging; Multimodal imaging; Radiation dosage; Radiopharmaceuticals; Sensitivity and specificity