Revealing human intestinal stem cell and crypt dynamics.
Stem cell and crypt dynamics in the human gut have been remarkably poorly characterized. We used random somatic mutations to trace stem cell lineages in the human intestine and coupled these data with mathematical modeling to infer the in vivo temporal dynamics of human intestinal stem cells.
Evolution and Cancer Laboratory; Barts Cancer Institute; Barts and the London School of Medicine and Dentistry; Queen Mary University of London ; London, UK.
Ann-Marie
AM
Baker
Evolution and Cancer Laboratory; Barts Cancer Institute; Barts and the London School of Medicine and Dentistry; Queen Mary University of London ; London, UK.
Trevor A
TA
Graham
clonal evolution; crypt life-cycle; human intestine; neutral drift; stem cell