Immunoglobulin G4-related sclerosing disease Mimicking sjogren's syndrome: A case report.
Immunoglobulin G4-related sclerosing disease (IgG4-RSD) is a fibroinflammatory condition that has the potential to affect nearly every organ system. Classic histological findings include storiform fibrosis and lymphoplasmacytic infiltrates of immunoglobulin G4 (IgG4)-positive plasma cells. The clinical features of IgG4-RSD may be an under-recognized disease process that can mimic other autoimmune disorders, including Sjogren's syndrome. We describe a rare case of IgG4-RSD involving the salivary glands, initially misdiagnosed as Sjogren's syndrome. Clinical features of IgG4-RSD can mimic those of other autoimmune disorders affecting the head and neck. Therefore, otolaryngologists should have IgG4-RSD on their differential when evaluating patients with diffuse salivary gland swelling. Laryngoscope, 126:2242-2245, 2016.
University of Arizona College of Medicine, Tucson, Arizona, U.S.A.. hcrees@email.arizona.edu.
Hilary C
HC
McCrary
Department of Otolaryngology-Head and Neck Surgery, University of Arizona College of Medicine, Tucson, Arizona, U.S.A.
Erynne A
EA
Faucett
Department of Otolaryngology-Head and Neck Surgery, University of Arizona College of Medicine, Tucson, Arizona, U.S.A.
Audrey B
AB
Erman
D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D012466:Salivary Gland Diseases / Q000175:diagnosis* / Q000276:immunology; D012859:Sjogren's Syndrome / Q000175:diagnosis*
D007074:Immunoglobulin G
Salivary glands; autoimmune diseases; immunoglobulin G; immunology; sjogren's syndrome