Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy.
Reports on the effect of prenatal vitamin D status on fetal immune development and infectious diseases in childhood are limited. The aim of this study was to investigate the role of maternal and cord blood vitamin D level in TLR-related innate immunity and its effect on infectious outcome. Maternal and cord blood 25 (OH)D level were examined from 372 maternal-neonatal pairs and their correlation with TLR-triggered TNF-α, IL-6, and IL-10 response at birth was assessed. Clinical outcomes related to infection at 12 months of age were also evaluated. The result showed that 75% of the pregnant mothers and 75.8% of the neonates were vitamin deficient. There was a high correlation between maternal and cord 25(OH)D levels (r = 0.67, p < 0.001). Maternal vitamin D level was inversely correlated with IL-10 response to TLR3 (p = 0.004) and TLR7-8 stimulation (p = 0.006). However, none of the TLR-triggered cytokine productions were associated with cord 25(OH)D concentration. There was no relationship between maternal and cord blood vitamin D status with infectious diseases during infancy. In conclusion, our study had shown that maternal vitamin D, but not cord vitamin D level, was associated with viral TLR-triggered IL-10 response.
Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan.
Sui-Ling
SL
Liao
Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan; Division of Pulmonology, Department of Pediatric, Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taoyuan 333, Taiwan.
Shen-Hao
SH
Lai
Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan.
Ming-Han
MH
Tsai
Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan.
Man-Chin
MC
Hua
Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taoyuan 204, Taiwan.
Kuo-Wei
KW
Yeh
Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan.
Kuan-Wen
KW
Su
Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan; Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan.
Chi-Hsin
CH
Chiang
Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan; Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan.
Shih-Yin
SY
Huang
Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan; Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan.
Chuan-Chi
CC
Kao
Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taoyuan 204, Taiwan.
Tsung-Chieh
TC
Yao
Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taoyuan 204, Taiwan.
Jing-Long
JL
Huang
D000328:Adult; D015331:Cohort Studies; D003141:Communicable Diseases / Q000097:blood*; D003470:Culture Media / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008024:Ligands; D008297:Male; D009000:Monocytes / Q000166:cytology; D011247:Pregnancy; D011446:Prospective Studies; D051193:Toll-Like Receptors / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014780:Viruses / Q000378:metabolism; D014807:Vitamin D / Q000097:blood*
D003470:Culture Media; C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D008024:Ligands; D051193:Toll-Like Receptors; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D014807:Vitamin D