CHCHD2 connects mitochondrial metabolism to apoptosis.
As the powerhouse of cells and gatekeeper for apoptosis, mitochondria control life and death. CHCHD2, a mitochondrial protein previously known to regulate metabolism, has recently been identified as an apoptosis inhibitor. New data suggest a model in which CHCHD2 performs a prosurvival function by acting as both a reactive oxygen species scavenger and BCL-XL activator.
Department of Radiation Oncology and Lineberger Comprehensive Cancer Center; School of Medicine; University of North Carolina at Chapel Hill; Chapel Hill, NC, USA; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy; Cancer Institute; Xuzhou Medical College; Xuzhou, Jiangsu, China.
Yong
Y
Liu
Department of Radiation Oncology and Lineberger Comprehensive Cancer Center; School of Medicine; University of North Carolina at Chapel Hill; Chapel Hill, NC, USA; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy; Cancer Institute; Xuzhou Medical College; Xuzhou, Jiangsu, China.
Yanping
Y
Zhang
apoptosis; metabolism; mitochondria; reactive oxygen species