Parathyroid Hormone Secretion Is Controlled by Both Ionized Calcium and Phosphate During Exercise and Recovery in Men.
The mechanism by which PTH is controlled during and after exercise is poorly understood due to insufficient temporal frequency of measurements.



The objective of the study was to examine the temporal pattern of PTH, PO4, albumin-adjusted calcium, and Ca(2+) during and after exercise.



This was a laboratory-based study with a crossover design, comparing 30 minutes of running at 55%, 65%, and 75% maximal oxygen consumption, followed by 2.5 hours of recovery. Blood was obtained at baseline, after 2.5, 5, 7.5, 10, 15, 20, 25, and 30 minutes of exercise, and after 2.5, 5, 7.5, 10, 15, 20, 25, 30, 60, 90, and 150 minutes of recovery.



Ten men (aged 23 ± 1 y, height 1.82 ± 0.07 m, body mass 77.0 ± 7.5 kg) participated.



PTH, PO4, albumin-adjusted calcium, and Ca(2+) were measured.



Independent of intensity, PTH concentrations decreased with the onset of exercise (-21% to -33%; P ≤ .001), increased thereafter, and were higher than baseline by the end of exercise at 75% maximal oxygen consumption (+52%; P ≤ .001). PTH peaked transiently after 5-7.5 minutes of recovery (+73% to +110%; P ≤ .001). PO4 followed a similar temporal pattern to PTH, and Ca(2+) followed a similar but inverse pattern to PTH. PTH was negatively correlated with Ca(2+) across all intensities (r = -0.739 to -0.790; P ≤ .001). When PTH was increasing, the strongest cross-correlation was with Ca(2+) at 0 lags (3.5 min) (r = -0.902 to -0.950); during recovery, the strongest cross-correlation was with PO4 at 0 lags (8 min) (r = 0.987-0.995).



PTH secretion during exercise and recovery is controlled by a combination of changes in Ca(2+) and PO4 in men.
Musculoskeletal Physiology Research Group (R.T., K.J.E.-S., C.T., C.S.), Sport, Health, and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom; School of Physical Education and Sport (A.J.P.), University of Sao Paulo, 05508-900 Sao Paulo, Brazil; Space Medicine Office (J.P.R.S.), European Astronaut Centre Department, Directorate of Human Spaceflight and Operations, European Space Agency, 64293 Darmstadt, Germany; Wyle GmbH (J.P.R.S.), Science Technology and Engineering Group, 51147 Köln, Germany; English Institute of Sport (R.T., K.C.), EIS Performance Centre, Loughborough University, Leicestershire LE11 3TU, United Kingdom; Norwich Medical School (W.D.F.), University of East Anglia, Norwich NR4 7TJ, United Kingdom; and Norwich University Hospital (W.D.F.), Norwich NR4 7UY, United Kingdom.
Rebecca
R
Townsend
Musculoskeletal Physiology Research Group (R.T., K.J.E.-S., C.T., C.S.), Sport, Health, and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom; School of Physical Education and Sport (A.J.P.), University of Sao Paulo, 05508-900 Sao Paulo, Brazil; Space Medicine Office (J.P.R.S.), European Astronaut Centre Department, Directorate of Human Spaceflight and Operations, European Space Agency, 64293 Darmstadt, Germany; Wyle GmbH (J.P.R.S.), Science Technology and Engineering Group, 51147 Köln, Germany; English Institute of Sport (R.T., K.C.), EIS Performance Centre, Loughborough University, Leicestershire LE11 3TU, United Kingdom; Norwich Medical School (W.D.F.), University of East Anglia, Norwich NR4 7TJ, United Kingdom; and Norwich University Hospital (W.D.F.), Norwich NR4 7UY, United Kingdom.
Kirsty J
KJ
Elliott-Sale
Musculoskeletal Physiology Research Group (R.T., K.J.E.-S., C.T., C.S.), Sport, Health, and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom; School of Physical Education and Sport (A.J.P.), University of Sao Paulo, 05508-900 Sao Paulo, Brazil; Space Medicine Office (J.P.R.S.), European Astronaut Centre Department, Directorate of Human Spaceflight and Operations, European Space Agency, 64293 Darmstadt, Germany; Wyle GmbH (J.P.R.S.), Science Technology and Engineering Group, 51147 Köln, Germany; English Institute of Sport (R.T., K.C.), EIS Performance Centre, Loughborough University, Leicestershire LE11 3TU, United Kingdom; Norwich Medical School (W.D.F.), University of East Anglia, Norwich NR4 7TJ, United Kingdom; and Norwich University Hospital (W.D.F.), Norwich NR4 7UY, United Kingdom.
Ana Jessica
AJ
Pinto
Musculoskeletal Physiology Research Group (R.T., K.J.E.-S., C.T., C.S.), Sport, Health, and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom; School of Physical Education and Sport (A.J.P.), University of Sao Paulo, 05508-900 Sao Paulo, Brazil; Space Medicine Office (J.P.R.S.), European Astronaut Centre Department, Directorate of Human Spaceflight and Operations, European Space Agency, 64293 Darmstadt, Germany; Wyle GmbH (J.P.R.S.), Science Technology and Engineering Group, 51147 Köln, Germany; English Institute of Sport (R.T., K.C.), EIS Performance Centre, Loughborough University, Leicestershire LE11 3TU, United Kingdom; Norwich Medical School (W.D.F.), University of East Anglia, Norwich NR4 7TJ, United Kingdom; and Norwich University Hospital (W.D.F.), Norwich NR4 7UY, United Kingdom.
Craig
C
Thomas
Musculoskeletal Physiology Research Group (R.T., K.J.E.-S., C.T., C.S.), Sport, Health, and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom; School of Physical Education and Sport (A.J.P.), University of Sao Paulo, 05508-900 Sao Paulo, Brazil; Space Medicine Office (J.P.R.S.), European Astronaut Centre Department, Directorate of Human Spaceflight and Operations, European Space Agency, 64293 Darmstadt, Germany; Wyle GmbH (J.P.R.S.), Science Technology and Engineering Group, 51147 Köln, Germany; English Institute of Sport (R.T., K.C.), EIS Performance Centre, Loughborough University, Leicestershire LE11 3TU, United Kingdom; Norwich Medical School (W.D.F.), University of East Anglia, Norwich NR4 7TJ, United Kingdom; and Norwich University Hospital (W.D.F.), Norwich NR4 7UY, United Kingdom.
Jonathan P R
JP
Scott
Musculoskeletal Physiology Research Group (R.T., K.J.E.-S., C.T., C.S.), Sport, Health, and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom; School of Physical Education and Sport (A.J.P.), University of Sao Paulo, 05508-900 Sao Paulo, Brazil; Space Medicine Office (J.P.R.S.), European Astronaut Centre Department, Directorate of Human Spaceflight and Operations, European Space Agency, 64293 Darmstadt, Germany; Wyle GmbH (J.P.R.S.), Science Technology and Engineering Group, 51147 Köln, Germany; English Institute of Sport (R.T., K.C.), EIS Performance Centre, Loughborough University, Leicestershire LE11 3TU, United Kingdom; Norwich Medical School (W.D.F.), University of East Anglia, Norwich NR4 7TJ, United Kingdom; and Norwich University Hospital (W.D.F.), Norwich NR4 7UY, United Kingdom.
Kevin
K
Currell
Musculoskeletal Physiology Research Group (R.T., K.J.E.-S., C.T., C.S.), Sport, Health, and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom; School of Physical Education and Sport (A.J.P.), University of Sao Paulo, 05508-900 Sao Paulo, Brazil; Space Medicine Office (J.P.R.S.), European Astronaut Centre Department, Directorate of Human Spaceflight and Operations, European Space Agency, 64293 Darmstadt, Germany; Wyle GmbH (J.P.R.S.), Science Technology and Engineering Group, 51147 Köln, Germany; English Institute of Sport (R.T., K.C.), EIS Performance Centre, Loughborough University, Leicestershire LE11 3TU, United Kingdom; Norwich Medical School (W.D.F.), University of East Anglia, Norwich NR4 7TJ, United Kingdom; and Norwich University Hospital (W.D.F.), Norwich NR4 7UY, United Kingdom.
William D
WD
Fraser
Musculoskeletal Physiology Research Group (R.T., K.J.E.-S., C.T., C.S.), Sport, Health, and Performance Enhancement Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom; School of Physical Education and Sport (A.J.P.), University of Sao Paulo, 05508-900 Sao Paulo, Brazil; Space Medicine Office (J.P.R.S.), European Astronaut Centre Department, Directorate of Human Spaceflight and Operations, European Space Agency, 64293 Darmstadt, Germany; Wyle GmbH (J.P.R.S.), Science Technology and Engineering Group, 51147 Köln, Germany; English Institute of Sport (R.T., K.C.), EIS Performance Centre, Loughborough University, Leicestershire LE11 3TU, United Kingdom; Norwich Medical School (W.D.F.), University of East Anglia, Norwich NR4 7TJ, United Kingdom; and Norwich University Hospital (W.D.F.), Norwich NR4 7UY, United Kingdom.
Craig
C
Sale
D000328:Adult; D002118:Calcium / Q000097:blood*; D018592:Cross-Over Studies; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006801:Humans; D007477:Ions / Q000097:blood; D008297:Male; D010101:Oxygen Consumption; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism*; D010710:Phosphates / Q000097:blood*; D005082:Physical Exertion / Q000502:physiology; D012146:Rest / Q000502:physiology; D012420:Running; D055815:Young Adult
D007477:Ions; D010281:Parathyroid Hormone; D010710:Phosphates; D002118:Calcium