Genetic polymorphisms of interleukin 1β gene and sporadic pancreatic neuroendocrine tumors susceptibility.
OBJECTIVE
To evaluate the association between the interleukin 1β (IL-1β) polymorphisms and the pancreatic neuroendocrine tumor (pNET) development.


METHODS
A case-control study was conducted analyzing IL-1β polymorphisms using germline DNA collected in a population-based case-control study of pancreatic cancer (51 pNET cases, 85 pancreatic ductal adenocarcinoma cases, 19 intraductal papillary mucinous neoplasm and 98 healthy controls).


RESULTS
The distribution of genotypes for the -511 C/T polymorphism in the pNET patient groups showed significant difference compared to the control group. It is known that the carriers of the IL-1β -511T allele have increased concentrations of IL-1β. The -511 CT and TT high-expression genotypes were over-represented in pNET patients.


CONCLUSIONS
The findings of this study suggested a possible role of IL-1β -511 C/T genotypes in the pathogenesis of pNETs since the presence of the IL-1β -511 CT and TT genotypes and the T allele was associated with an increased risk of pNET only.
Dimitrios Karakaxas, Christos Dervenis, Department of General Surgery, Agia Olga Hospital, 14233 Athens, Greece.
Dimitrios
D
Karakaxas
Dimitrios Karakaxas, Christos Dervenis, Department of General Surgery, Agia Olga Hospital, 14233 Athens, Greece.
Anna
A
Sioziou
Dimitrios Karakaxas, Christos Dervenis, Department of General Surgery, Agia Olga Hospital, 14233 Athens, Greece.
Gerasimos
G
Aravantinos
Dimitrios Karakaxas, Christos Dervenis, Department of General Surgery, Agia Olga Hospital, 14233 Athens, Greece.
Ahmet
A
Coker
Dimitrios Karakaxas, Christos Dervenis, Department of General Surgery, Agia Olga Hospital, 14233 Athens, Greece.
Ioannis S
IS
Papanikolaou
Dimitrios Karakaxas, Christos Dervenis, Department of General Surgery, Agia Olga Hospital, 14233 Athens, Greece.
Theodoros
T
Liakakos
Dimitrios Karakaxas, Christos Dervenis, Department of General Surgery, Agia Olga Hospital, 14233 Athens, Greece.
Christos
C
Dervenis
Dimitrios Karakaxas, Christos Dervenis, Department of General Surgery, Agia Olga Hospital, 14233 Athens, Greece.
Maria
M
Gazouli
Interleukin 1β; Neuroendocrine tumors; Pancreas