[The Meaning of Neurological and Psychiatric Disease and Addiction for Pregnancy Outcome: A Case-control Study of the Birth Cohort 2010-2012].
OBJECTIVE
The worldwide prevalence of neurological and psychiatric illnesses is steadily increasing. Consequently women of childbearing age are concerned as well. This survey examines the question of what kind of effects these illnesses have prenatally on mother and child.


METHODS
In a case-control study, differences in pregnancy, birth process, and birth outcome were associated with a neurological or psychiatric illness of the expectant mother. 325 pregnant women with 331 born children were identified as cases, which were compared to 5 103 non diseased pregnant women with 5 195 born children.


RESULTS
The age of the mother for admission was significantly lower in the case group than in the control group. The number of previous gestations and the number of previous induced abortion were significantly higher in the case group. Also the BMI before pregnancy and the length of stationary stay showed significantly higher values in the case group. Children belonging to the case group were born significantly earlier, had a lower birth weight, height, and head circumference. Furthermore Apgar scores were significantly lower in the case group. The frequency of postpartum stationary stay in a children's clinic as well as the length of stationary stay were also significantly higher when the mother suffered from a neurological or a psychiatric illness.


CONCLUSIONS
The present results point out the correlation between most of the tested parameters and a neuropsychiatric illness of the newborn's mother. The interdisciplinary collaboration between gynecologists and pediatricians, as well as neurologists and psychiatrists should be strengthened to guarantee the best possible medical care.
Fehlbildungsmonitoring Sachsen-Anhalt, Medizinische Fakultät der Otto-von-Guericke Universität Magdeburg, Magdeburg.
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Grunwald
Universitätskinderklinik, Medizinische Fakultät, Otto-von-Guericke Universität Magdeburg, Magdeburg, Sachsen-Anhalt.
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Jorch
Institut für Biometrie und Medizinische Informatik, Medizinische Fakultät Otto-von-Guericke Universität Magdeburg, Magdeburg.
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Kropf
Klinik für Frauenheilkunde und Geburtshilfe, Perinatalzentrum, KH St. Elisabeth und St. Barbara Halle, Halle/Saale.
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Seeger
Universitätsklinik und Poliklinik für Geburtshilfe und Pränatalmedizin, Martin-Luther Universität Halle/Saale, Halle.
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Seliger
Fehlbildungsmonitoring Sachsen-Anhalt, Medizinische Fakultät der Otto-von-Guericke Universität Magdeburg, Magdeburg.
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Rißmann
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D016022:Case-Control Studies; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005858:Germany / Q000453:epidemiology; D020073:Gravidity; D006801:Humans; D015994:Incidence; D007902:Length of Stay / Q000706:statistics & numerical data*; D001523:Mental Disorders / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D009422:Nervous System Diseases / Q000175:diagnosis / Q000453:epidemiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology*; D055815:Young Adult