Nocardia transvalensis Disseminated Infection in an Immunocompromised Patient with Idiopathic Thrombocytopenic Purpura.
Nocardia transvalensis complex includes a wide range of microorganisms with specific antimicrobial resistance patterns. N. transvalensis is an unusual Nocardia species. However, it must be differentiated due to its natural resistance to aminoglycosides while other Nocardia species are susceptible. The present report describes a Nocardia species involved in an uncommon clinical case of a patient with idiopathic thrombocytopenic purpura and pulmonary nocardiosis. Microbiological and molecular techniques based on the sequencing of the 16S rRNA gene allowed diagnosis of Nocardia transvalensis sensu stricto. The successful treatment was based on trimethoprim-sulfamethoxazole and other drugs. We conclude that molecular identification of Nocardia species is a valuable technique to guide good treatment and prognosis and recommend its use for daily bases diagnosis.
Departamento de Posgrado y Educación Médica Continua, Instituto Nacional de Cancerología, Mexico; Departamento de Microbiología, Facultad de Medicina, UNAM, 04510 Coyoacán, MEX, Mexico.
Jorge
J
García-Méndez
Departamento de Biología Molecular e Histocompatibilidad, Dirección de Investigación, Hospital General "Dr. Manuel Gea González", 14080 Tlalpan, MEX, Mexico.
Erika M
EM
Carrillo-Casas
Laboratorio de Microbiología Clínica, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", 14080 Tlalpan, MEX, Mexico.
Andrea
A
Rangel-Cordero
Departamento de Biología Molecular e Histocompatibilidad, Dirección de Investigación, Hospital General "Dr. Manuel Gea González", 14080 Tlalpan, MEX, Mexico.
Margarita
M
Leyva-Leyva
Departamento de Infectología, Hospital Infantil de México "Federico Gómez", Dr. Márquez 162, Cuauhtémoc, 06720 Ciudad de México, DF, Mexico.
Juan
J
Xicohtencatl-Cortes
Servicio de Micología, Hospital General "Dr. Manuel Gea González", 14080 Tlalpan, MEX, Mexico.
Roberto
R
Arenas
Departamento de Ecología de Agentes Patógenos, Hospital General "Dr. Manuel Gea González", 14080 Tlalpan, MEX, Mexico.
Rigoberto
R
Hernández-Castro