G-Protein Gαs controls medulloblastoma initiation by suppressing sonic hedgehog signaling.
We identify Gαs as a novel tumor suppressor in medulloblastoma that functions principally by inhibition of sonic hedgehog signaling. Gαs not only stimulates cyclic adenosine monophosphate (cAMP)-dependent signaling but also inhibits ciliary trafficking of hedgehog components. Elevation of cAMP inhibits medulloblastoma growth and augments inhibition of smoothened to decrease tumor cell proliferation, thus highlighting Gαs as a potential therapeutic target.
Department of Pediatrics, Brain Tumor Center; Divisions of Experimental Hematology and Cancer Biology & Developmental Biology; Cancer and Blood Diseases Institute; Cincinnati Children's Hospital Medical Center; University of Cincinnati College of Medicine ; Cincinnati, OH USA.
Xuelian
X
He
Department of Pediatrics, Brain Tumor Center; Divisions of Experimental Hematology and Cancer Biology & Developmental Biology; Cancer and Blood Diseases Institute; Cincinnati Children's Hospital Medical Center; University of Cincinnati College of Medicine ; Cincinnati, OH USA.
Q Richard
QR
Lu
Cilia; G-protein; GNAS; GPCR; Smoothened; Sonic hedgehog signaling; cAMP; medulloblastoma; pediatric brain tumors; tumor cell origins