EglN2 positively regulates mitochondrial function in breast cancer.
Oxygen sensing is associated with mitochondrial function. EglN2, which contributes to breast tumorigenesis as a prolyl hydroxylase, has recently been identified as a transcription co-activator through interaction with NRF1 and PGC1α to regulate mitochondrial function under conditions of normoxia and hypoxia. FDXR is the important downstream target gene that mediates this regulation.
Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine , Chapel Hill, NC, USA.
Jing
J
Zhang
Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine , Chapel Hill, NC, USA.
Xingnan
X
Zheng
Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.
Qing
Q
Zhang
Breast cancer; EglN2; FDXR; hypoxia; mitochondria