Flow and Thixotropic Parameters for Rheological Characterization of Hydrogels.
The goal of this paper was to design several sodium carboxymethylcellulose hydrogels containing a BCS class II model drug and to evaluate their flow and thixotropic properties. The rheological measurements were performed at two temperatures (23 °C and 37 °C), using a rotational viscometer. The hydrogels were stirred at different time intervals (10 s, 2, 5, 10 and 20 min at 23 °C, and 10 s, 2 and 5 min at 37 °C), with a maximum rotational speed of 60 rpm, and the corresponding forward and backward rheograms were recorded as shear stress vs. shear rate. For all hydrogels, the rheological data obtained at both temperatures showed a decrease of viscosity with the increase of the shear rate, highlighting a pseudoplastic behaviour. The flow profiles viscosity vs. shear rate were quantified through power law model, meanwhile the flow curves shear stress vs. shear rate were assessed by applying the Herschel-Bulkley model. The thixotropic character was evaluated through different descriptors: thixotropic area, thixotropic index, thixotropic constant and destructuration thixotropic coefficient. The gel-forming polymer concentration and the rheological experiments temperature significantly influence the flow and thixotropic parameters values of the designed hydrogels. The rheological characteristics described have an impact on the drug release microenvironment and determine the stasis time at the application site.
Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", Bucharest 020956, Romania. mihaelaghica@yahoo.com.
Mihaela Violeta
MV
Ghica
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", Bucharest 020956, Romania. mircea.hirjau@gmail.com.
Mircea
M
Hîrjău
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", Bucharest 020956, Romania. office@colegfarm.ro.
Dumitru
D
Lupuleasa
Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", Bucharest 020956, Romania. ecristinaparvu@yahoo.com.
Cristina-Elena
CE
Dinu-Pîrvu
D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012212:Rheology; D033081:Shear Strength; D013696:Temperature; D014783:Viscosity
D020100:Hydrogels; D011108:Polymers; D002266:Carboxymethylcellulose Sodium
flow parameters; hydrogel; rheological models; thixotropic descriptors