Persistent Drug-Induced Parkinsonism in Patients with Normal Dopamine Transporter Imaging.
Functional neuroimaging for the dopamine transporter (DAT) is used to distinguish drug-induced parkinsonism (DIP) from subclinical Parkinson's disease (PD). Although DIP patients who show a normal DAT image are expected to recover completely, some do not. We investigated whether these patients showed changes in striatal DAT activity using semi-quantitative analysis of 18F-FP-CIT PET data. DIP patients with visually normal DAT images were selected from medical records. The subjects were classified as patients who recovered partially (PR) or completely within 12 months (CR). The 18F-FP-CIT uptake in each striatal subregion was compared between the CR and the PR groups. In total, 41 and 9 patients of the CR and PR groups were assessed, respectively. The two patient groups were comparable in terms of clinical characteristics including age, sex, and severity of parkinsonism. From semi-quantitative analysis of the PET image, the PR patients showed a relatively lower ligand uptake in the ventral striatum, the anterior putamen and the posterior putamen compared with the CR patients. This result suggests that persistent DIP in patients with visually normal DAT imaging may be associated with subtle decrement of DAT activity.
Department of Neurology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Jin Yong
http://orcid.org/0000-0002-2476-3737
JY
Hong
Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, Korea.
Mun Kyung
MK
Sunwoo
Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jungsu S
JS
Oh
Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jae Seung
JS
Kim
Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Young H
YH
Sohn
Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.|Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.
Phil Hyu
PH
Lee
D000368:Aged; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins / Q000032:analysis* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D020734:Parkinsonian Disorders / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods
D050483:Dopamine Plasma Membrane Transport Proteins