Effectiveness of High-dose Spironolactone Therapy in a Patient with Recurrent Protein-losing Enteropathy after the Fontan Procedure.
Protein-losing enteropathy (PLE) is a rare and life-threatening complication that occurs after the Fontan procedure. We herein report the case of an 11-year-old Japanese boy who developed PLE six times after undergoing the Fontan procedure. High-dose spironolactone therapy has been effective for 2 years. His high level of serum aldosterone decreased to a nearly normal range and spironolactone may have a diuretic and anti-inflammatory potential.
Department of Pediatrics, Asahikawa Medical University, Japan.
Satomi
S
Okano
Masaya
M
Sugimoto
Masashi
M
Takase
Kenichi
K
Iseki
Aya
A
Kajihama
Hiroshi
H
Azuma
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002648:Child; D004232:Diuretics / Q000627:therapeutic use*; D018729:Fontan Procedure / Q000009:adverse effects*; D006801:Humans; D007564:Japan; D008297:Male; D011504:Protein-Losing Enteropathies / Q000188:drug therapy* / Q000209:etiology*; D013148:Spironolactone / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D004232:Diuretics; D013148:Spironolactone