[A Case of Drug-Induced Lung Injury Associated with Paclitaxel plus Bevacizumab Therapy].
A 61-year old woman with recurrent breast cancer received combined treatment with paclitaxel (PTX) and bevacizumab (BV) as the third-line chemotherapy. During the administration of PTX in the 3 courses of chemotherapy, she suddenly developed respiratory failure, and both chest X-ray and CT revealed bilateral pulmonary infiltrates. Symptoms and radiographic findings responded dramatically to steroid pulse therapy. The history of onset and laboratory data showed no evidence of infection; therefore, we made a diagnosis of acute lung injury induced by the chemotherapy. It should be noted that lung injury may be induced by both PTX and BV, and is one of the important adverse events despite the low frequency of occurrence.
Dept. of Surgery, Tottori Red Cross Hospital.
Yumi
Y
Yamaguchi
Yoichiro
Y
Tada
Seigo
S
Takaya
Akemi
A
Iwamoto
Yutaka
Y
Yamashiro
Shunsuke
S
Shibata
Minoru
M
Ishiguro
Hideaki
H
Nishidoi
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D000068258:Bevacizumab / Q000008:administration & dosage / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D055370:Lung Injury / Q000139:chemically induced* / Q000188:drug therapy; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D020551:Pulse Therapy, Drug; D012120:Respiration Disorders / Q000209:etiology; D013256:Steroids / Q000627:therapeutic use
D013256:Steroids; D000068258:Bevacizumab; D017239:Paclitaxel