Pancreatic Cancer: Planning Ahead for Metastatic Spread.
Metastasis and therapy resistance are cardinal features of pancreatic ductal adenocarcinoma, a commonly lethal malignancy. In this issue of Cancer Cell, Steele et al. show that CXCR2 expression and neutrophils are required for metastasis. In mice treated with advanced disease, inhibiting both CXCR2 and PD1 cooperatively but not individually prolongs survival.
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: istromne@fredhutch.org.
Ingunn M
IM
Stromnes
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Medical Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA; Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA. Electronic address: pgreen@uw.edu.
Philip D
PD
Greenberg
D000230:Adenocarcinoma; D000818:Animals; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000378:metabolism*