Discovery and validation of the antimetastatic activity of citalopram in colorectal cancer.
Inverse gene expression profiling was recently shown to help drug repositioning. We showed that this approach works best for cancer and predicted novel drug candidates that may reduce metastasis in colorectal cancer. Antimetastatic activity of our predicted candidate, citalopram, was validated in an orthotopic mouse model of metastatic colorectal cancer.
Structural and Computational Biology Unit; European Molecular Biology Laboratory ; Heidelberg, Germany.
Murat
M
Iskar
Structural and Computational Biology Unit; European Molecular Biology Laboratory; Heidelberg, Germany; Max-Delbrück-Centre (MDC) for Molecular Medicine; Berlin, Germany.
Peer
P
Bork
Department of Microbial and Molecular Systems (M2S); KU Leuven ; Leuven, Belgium.
Vera
V
van Noort
citalopram; colorectal cancer; drug-repositioning; metastasis; orthotopic model; systems pharmacology