Silymarin versus Silibinin: Differential Antioxidant and Neuroprotective Effects against H2O2-induced Oxidative Stress in PC12 Cells.
The present study assessed comparatively the antioxidant activities of silymarin and its major active component silibinin and their neuroprotective effects against hydrogen peroxide (H2O2)-induced oxidative stress in rat pheochromocytoma PC12 cells. It was found that despite newly prepared silymarin and silibinin solution possessing comparable superoxide anion (O2*-)-scavenging activities, with time the activity of silymarin lowered slightly, but that of silibinin decreased dramatically. Both silymarin and silibinin suppressed H2O2-induced oxidative stress and apoptosis, and the neuroprotective effect of silymarin was overall relatively stronger than that of silibinin. The findings provided clues for future studies on therapeutic potentials of the whole silymarin or purified silibinin for neurodegenerative diseases.
Hui-Hui
HH
Jiang
Fa-Shun
FS
Yan
Liang
L
Shen
Hong-Fang
HF
Ji
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D006861:Hydrogen Peroxide; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D016716:PC12 Cells; D051381:Rats; D000077385:Silybin; D012838:Silymarin / Q000494:pharmacology*
D000975:Antioxidants; D018696:Neuroprotective Agents; D012838:Silymarin; D000077385:Silybin; D006861:Hydrogen Peroxide