Targeting hexokinase 2 in castration-resistant prostate cancer.
Aerobic glycolysis, known as the Warburg effect, is one of the hallmarks of cancer cells. We recently reported that the hexokinase 2 (HK2)-mediated Warburg effect is required for castration-resistant prostate cancer that is driven by Pten/p53 deficiency, suggesting that HK2 might be a therapeutic target for prostate cancer patients carrying PTEN and p53 mutations.
Laboratory of Cancer Genetics; The University of Minnesota Hormel Institute ; Austin, MN USA.
Yibin
Y
Deng
Department of Biomedical Sciences; Texas Tech University Health Sciences Center School of Pharmacy ; Amarillo, TX USA.
Junxuan
J
Lu
CRPC; HK2; PTEN; Warburg effect; p53