Dicer in action at replication-transcription collisions.
Maintaining genome stability at sites of transcription and replication collision is a major challenge to cells. Recently, we have shown that in Schizosaccharomyces pombe Dicer promotes transcription termination at these sites, facilitating DNA replication and preventing replication fork restart that would otherwise occur via homologous recombination at the expense of genome stability. This novel role of Dicer could further explain its previously described role as a tumor suppressor.
Howard Hughes Medical Institute-Gordon and Betty Moore Foundation; Watson School of Biological Sciences; Cold Spring Harbor Laboratory; Cold Spring Harbor , NY, USA.
Jie
J
Ren
Howard Hughes Medical Institute-Gordon and Betty Moore Foundation; Watson School of Biological Sciences; Cold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA; Present Address: New York Genome Center; New York, NY, USA.
Stephane E
SE
Castel
Howard Hughes Medical Institute-Gordon and Betty Moore Foundation; Watson School of Biological Sciences; Cold Spring Harbor Laboratory; Cold Spring Harbor , NY, USA.
Robert A
RA
Martienssen
Dicer; genome stability; replication stress; transcription termination; tumor suppressor