Phase IA Clinical Trial Evaluating the Tolerability, Pharmacokinetics, and Analgesic Efficacy of an Intrathecally Administered Neurotensin A Analogue in Central Neuropathic Pain Following Spinal Cord Injury.
We evaluated CGX-1160 in a Phase Ia clinical trial to determine the safety of escalating doses in patients with central neuropathic pain following spinal cord injury (SCI). Our secondary objective was to detect a trend toward analgesic efficacy. Four subjects received 3 consecutive escalating doses of CGX-1160 starting at 25 μg/h over 6 hours until 2 consecutive subjects experienced any adverse effect; 2 of the 4 subjects received 2 sequences of 3 consecutive dose escalations. Maximum tolerated dose was defined by the development of diarrhea (900 μg/h over 6 hours). Cerebrospinal fluid (CSF) and blood were collected for pharmacokinetic (PK) evaluation. The CSF concentration-versus-time data fit to a biexponential PK model, showing a rapid redistribution phase followed by a significantly slower terminal elimination phase. Incorporating an effect site delay into the model improved the fit to the data (concentration producing 50% of the maximum effect [C50 ], 58.7 ug/mL at the site of drug effect). Maximal reduction from the baseline pain intensity was 63%. In summary, CGX-1160 was generally well tolerated when administered intrathecally at doses up to 1000 μg/h. Peak analgesic effect occurred after the peak intrathecal concentration, indicating the presence of an effect site compartment to the PK model to represent the concentration and effect profiles for this unique compound.
Translational Pain Research, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Christine N
CN
Sang
Translational Pain Research, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kate J
KJ
Barnabe
Quantitative Science, Bill & Melinda Gates Foundation, Seattle, WA, USA.
Steven E
SE
Kern
D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D006023:Glycoproteins / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D006801:Humans; D007278:Injections, Spinal; D020714:Maximum Tolerated Dose; D008954:Models, Biological; D009437:Neuralgia / Q000188:drug therapy* / Q000209:etiology; D009479:Neuropeptides / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D009496:Neurotensin / Q000031:analogs & derivatives; D013119:Spinal Cord Injuries / Q000188:drug therapy*; D016896:Treatment Outcome
D000700:Analgesics; D006023:Glycoproteins; D009479:Neuropeptides; C119349:contulakin-G protein, Conus geographus; D009496:Neurotensin
central neuropathic pain; conotoxin; pharmacodynamics; pharmacokinetics; spinal cord injury