p32: A new player in autophagy.
Unc-51 like kinase-1 (Ulk1) is essential for autophagy induction. We recently reported that p32/C1QBP is crucial for the induction of autophagic flux upon starvation and the clearance of damaged mitochondria through the regulation of Ulk1 stability and kinase activity. Our results underscore the importance of p32 in fine-tuning the stress response and mitochondrial homeostasis via Ulk1.
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University , Xiamen, Fujian, China.
Haifeng
H
Jiao
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University , Xiamen, Fujian, China.
Han
H
You
Autophagy; p32; ULK1