Integrating heterogeneous drug sensitivity data from cancer pharmacogenomic studies.
The consistency of in vitro drug sensitivity data is of key importance for cancer pharmacogenomics. Previous attempts to correlate drug sensitivities from the large pharmacogenomics databases, such as the Cancer Cell Line Encyclopedia (CCLE) and the Genomics of Drug Sensitivity in Cancer (GDSC), have produced discordant results. We developed a new drug sensitivity metric, the area under the dose response curve adjusted for the range of tested drug concentrations, which allows integration of heterogeneous drug sensitivity data from the CCLE, the GDSC, and the Cancer Therapeutics Response Portal (CTRP). We show that there is moderate to good agreement of drug sensitivity data for many targeted therapies, particularly kinase inhibitors. The results of this largest cancer cell line drug sensitivity data analysis to date are accessible through the online portal, which serves as a platform for high power pharmacogenomics analysis.
Department of Medicine, University of Colorado Cancer Center, University of Colorado School of Medicine, Aurora, CO, USA.
Nikita
N
Pozdeyev
Department of Medicine, University of Colorado Cancer Center, University of Colorado School of Medicine, Aurora, CO, USA.
Minjae
M
Yoo
Department of Medicine, University of Colorado Cancer Center, University of Colorado School of Medicine, Aurora, CO, USA.
Ryan
R
Mackie
Department of Medicine, University of Colorado Cancer Center, University of Colorado School of Medicine, Aurora, CO, USA.
Rebecca E
RE
Schweppe
Department of Medicine, University of Colorado Cancer Center, University of Colorado School of Medicine, Aurora, CO, USA.
Aik Choon
AC
Tan
Department of Medicine, University of Colorado Cancer Center, University of Colorado School of Medicine, Aurora, CO, USA.
Bryan R
BR
Haugen
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D003625:Data Collection / Q000379:methods*; D030541:Databases, Genetic; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D023281:Genomics / Q000379:methods; D006801:Humans; D016247:Information Storage and Retrieval; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics; D000071185:Pharmacogenomic Testing; D014584:User-Computer Interface
D000970:Antineoplastic Agents
cancer; cell line; database integration; drug sensitivity; pharmacogenomics