Transglutaminase type 2: A multifunctional protein chaperone?
Macroautophagy selectively degrades dysfunctional mitochondria by a process known as mitophagy. The purpose of the study published in Cell Death and Differentiation was to investigate the involvement of transglutaminase 2 (TG2) in the turnover and degradation of damaged mitochondria and its effects on cell metabolism.
Department of Biology; University of Rome "Tor Vergata," Rome, Italy.
Federica
F
Rossin
Department of Biology; University of Rome "Tor Vergata," Rome, Italy.
Manuela
M
D'Eletto
Department of Biology; University of Rome "Tor Vergata," Rome, Italy.
Maria Grazia
MG
Farrace
Department of Biology; University of Rome "Tor Vergata," Rome, Italy; National Institute for infectious Disease Istituto di Ricovero e Cura a Carattere Scientifico "Lazzaro Spallanzani," Rome, Italy.
Mauro
M
Piacentini
Drp1; autophagy; glycolysis; mitophagy; transglutaminase 2