Atypical granular cell tumor in the maxilla: The first report of primary intraosseous granular cell tumor.
Granular cell tumor (GCT) is a benign soft tissue tumor of neural origin and is characterized by eosinophilic granular cells showing positivity for neuronal markers. Herein, we report the first case of primary intraosseous GCT arising in the maxilla of an adolescent girl.



A 16-year-old female patient presented with palatal swelling. Radiographic findings revealed a well-defined radiolucent lesion centrally located in the right maxilla. Mass excision was performed, and histopathologic examination showed sheets and cords of eosinophilic granular cells with cellular pleomorphism. Tumor cells were strongly positive for vimentin, S-100 protein, and CD56, and negative for cytokeratin, desmin, smooth muscle actin, and c-kit. High expression of p53 and Ki-67 was found. The final diagnosis was atypical GCT.



When evaluating an intraosseous radiolucent lesion with histopathologic features of granular cells, clinicians and pathologists should include GCT in the differential diagnosis. © 2016 Wiley Periodicals, Inc. Head Neck 38:E2467-E2470, 2016.
Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
Kyu-Young
KY
Oh
Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
Kyung-Rim
KR
Kang
Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
Hye-Jung
HJ
Yoon
Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
Jae-Il
JI
Lee
Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
Sam-Pyo
SP
Hong
Department of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
Seong-Doo
SD
Hong
D000293:Adolescent; D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006106:Granulosa Cell Tumor / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008441:Maxillary Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D011862:Radiography, Panoramic; D035583:Rare Diseases; D014057:Tomography, X-Ray Computed
atypical; granular cell tumor; immunohistochemistry; intraosseous; maxilla