Targeting the Warburg effect for leukemia therapy: Magnitude matters.
Non-oxidative glucose metabolism represents a hallmark of cancer. It is now apparent that different cell states among normal stem or progenitor cells have distinct aerobic glycolysis (AG) dependencies. However, malignant cells are markedly more vulnerable to modifications of AG regardless of the differentiation state of their cell of origin.
Center for Regenerative Medicine and Cancer Center; Massachusetts General Hospital; Boston, MA USA; Harvard Stem Cell Institute; Cambridge, MA USA; Department of Stem Cell and Regenerative Biology; Harvard University; Cambridge, MA USA.
Ying-Hua
YH
Wang
Center for Regenerative Medicine and Cancer Center; Massachusetts General Hospital; Boston, MA USA; Harvard Stem Cell Institute; Cambridge, MA USA; Department of Stem Cell and Regenerative Biology; Harvard University; Cambridge, MA USA.
David T
DT
Scadden
aerobic glycolysis; hematopoiesis; leukemia; metabolism; progenitor cells; stem cells