SHOT-RNAs: A novel class of tRNA-derived functional RNAs expressed in hormone-dependent cancers.
Sex hormones and their receptors play critical roles in the genesis and progression of breast and prostate cancers. We recently discovered that sex hormone signaling pathways promote the expression of specific tRNA halves termed Sex HOrmone-dependent TRNA-derived RNAs (SHOT-RNAs). Functional involvement of SHOT-RNAs in cell proliferation suggests a novel tRNA-engaged pathway in tumorigenesis.
Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University , Philadelphia, Pennsylvania, USA.
Shozo
S
Honda
Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University , Philadelphia, Pennsylvania, USA.
Yohei
Y
Kirino
Androgen receptor; SHOT-RNA; angiogenin; breast cancer; cyclic phosphate; estrogen receptor; prostate cancer; tRNA; tRNA fragment; tRNA half