[Can fish oil improve wound healing in surgery?].
A surgical insult induces both local and systemic inflammatory responses which, if inappropriate, could impair wound healing. According to many studies ω-3 polyunsaturated fatty acids from fish oil improve the process of wound healing by their immunomodulatory effect. In contrast to current anti-inflammatory drugs, which could alter immune defence and impair the resolution of inflammation, ω-3 fatty acids have a simultaneous anti-inflammatory pro-resolution effect which is not immunosuppressive. Besides that they improve cicatrix quality. With regard to this effect they prevent excessive or prolonged inflammation and wound complications.


BACKGROUND
anti-inflammatory agent - cicatrix - fish oil - macrophage - ω-3 fatty acid - resolution of inflammation - Toll-like receptor - wound healing.
Jana
J
Neuwirthová
Břetislav
B
Gál
Pavla
P
Urbánková
Pavel
P
Smilek
D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002921:Cicatrix / Q000188:drug therapy; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D014945:Wound Healing / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D015525:Fatty Acids, Omega-3