H3K9me3-mediated repression of KLF6: Discovering a novel tumor suppressor in liposarcoma using a systematic epigenomic approach.
The pathogenesis of well-differentiated and dedifferentiated liposarcoma is poorly understood. We recently reported Kruppel-like factor 6 (KLF6) as a histone H3 lysine 9 trimethyl (H3K9me3)-regulated and differentially expressed transcription factor serving a previously unappreciated tumor suppressor role in liposarcoma. Mechanistically, KLF6 may drive adipocytic differentiation through increased expression of known regulators of adipogenesis.
Department of Surgery, Brigham and Women's Hospital , Boston, MA, USA.
Emily Z
EZ
Keung
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.
Kunal
K
Rai
Dedifferentiated; H3K9me3; KLF6; epigenetics; liposarcoma; well differentiated