Metal-Free, Phosphonium Salt-Mediated Sulfoximination of Azine N-Oxides: Approach for the Synthesis of N-Azine Sulfoximines.
Herein, we report a simple and metal-free method for the synthesis of N-azine sulfoximines by the nucleophilic substitution of azine N-oxides with NH-sulfoximines. The present method works at room temperature with wide functional group compatibility and gives several unprecedented N-azine sulfoximines. The reaction conditions were also found suitable with enantiopure substrates and furnished products without any racemization. It also finds an application in the sulfoximination of azine-based functional molecules such as 2,2'-bipyridine, 1,10-phenanthroline, and quinine.
Medicinal Chemistry Division, Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu-180001, India.
Sravan Kumar
SK
Aithagani
Medicinal Chemistry Division, Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu-180001, India.
Mukesh
M
Kumar
Medicinal Chemistry Division, Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu-180001, India.
Mahipal
M
Yadav
Medicinal Chemistry Division, Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu-180001, India.
Ram A
RA
Vishwakarma
Medicinal Chemistry Division, Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu-180001, India.
Parvinder Pal
PP
Singh