Reduced heart rate variability in remitted bipolar disorder and recurrent depression.
OBJECTIVE
There is evidence that mood disorders are associated with impaired parasympathetic nervous system function and consequently increased morbidity and mortality. Our study addresses whether this impairment persists into remission in unipolar and bipolar disorders.


METHODS
Heart Rate Variability was measured in groups of subjects during remission, with Bipolar Affective Disorder I (n = 29), recurrent Major Depressive Disorder (n = 41) and a healthy control group (n = 38), during the bedtime period.


RESULTS
Heart Rate Variability was found to be lower in the bipolar and depression groups, compared with control subjects, using the Root Mean Square of Successive Distances variable, and lower in the depression group using the Standard Deviation of Normal to Normal variable and the Standard Deviation, Poincare Plot variable.


CONCLUSIONS
Autonomic function during bedtime was impaired in subjects with Bipolar I and recurrent Major Depressive Disorder, despite clinical remission. This has significant implications for the morbidity and mortality of patients with major mood disorders.
University of Notre Dame, Fremantle, WA, Australia The University of Western Australia, Nedlands, WA, Australia Hollywood Specialist Centre, Nedlands, WA, Australia dbassett@drbassett.com.au.
Darryl
D
Bassett
Telethon Kids Institute, Subiaco, WA, Australia.
Natasha
N
Bear
Imperial College London, London, UK.
David
D
Nutt
School of Psychiatry and Clinical Neurosciences, The University of Western Australia, Nedlands, WA, Australia.
Sean
S
Hood
Hollywood Specialist Centre, Nedlands, WA, Australia.
Sherylee
S
Bassett
Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Davinder
D
Hans
D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000209:etiology / Q000503:physiopathology*; D001714:Bipolar Disorder / Q000150:complications / Q000503:physiopathology*; D003865:Major Depressive Disorder / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence
Heart rate variability; bipolar; depression; remission; sleep