Plasma membrane repairs by small GTPase Rab3a.
Lysosomes fuse with the plasma membrane to help repair membrane lesions, but how they are positioned close to these lesions is not fully understood. Now, Encarnação et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511093) demonstrate that the lysosomal GTPase Rab3a and its effectors orchestrate lysosome positioning and plasma membrane repair.
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.
Camilla
0000-0002-5406-5403
C
Raiborg
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway stenmark@ulrik.uio.no.
Harald
H
Stenmark
D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism* / Q000502:physiology*; D005057:Eukaryotic Cells / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008247:Lysosomes / Q000378:metabolism / Q000502:physiology; D020826:rab3A GTP-Binding Protein / Q000378:metabolism*
D020826:rab3A GTP-Binding Protein; D002118:Calcium