Long-Range Temporal Correlations in the amplitude of alpha oscillations predict and reflect strength of intracortical facilitation: Combined TMS and EEG study.
While variability of the motor responses to transcranial magnetic stimulation (TMS) is widely acknowledged, little is known about its central origin. One plausible explanation for such variability may relate to different neuronal states defining the reactivity of the cortex to TMS. In this study intrinsic spatio-temporal neuronal dynamics were estimated with Long-Range Temporal Correlations (LRTC) in order to predict the inter-individual differences in the strength of intra-cortical facilitation (ICF) and short-interval intracortical inhibition (SICI) produced by paired-pulse TMS (ppTMS) of the left primary motor cortex. LRTC in the alpha frequency range were assessed from multichannel electroencephalography (EEG) obtained at rest before and after the application of and single-pulse TMS (spTMS) and ppTMS protocols. For the EEG session, preceding TMS application, we showed a positive correlation across subjects between the strength of ICF and LRTC in the fronto-central and parietal areas. This in turn attests to the existence of subject-specific neuronal phenotypes defining the reactivity of the brain to ppTMS. In addition, we also showed that ICF was associated with the changes in neuronal dynamics in the EEG session after the application of the stimulation. This result provides a complementary evidence for the recent findings demonstrating that the cortical stimulation with sparse non-regular stimuli might have considerable long-lasting effects on the cortical activity.
Centre for Cognition and Decision Making, National Research University Higher School of Economics, Russian Federation; Department of Neurosurgery, Unispital Zurich, University of Zurich, Switzerland. Electronic address: tommaso.fedele@usz.ch.
Tommaso
T
Fedele
Centre for Cognition and Decision Making, National Research University Higher School of Economics, Russian Federation; Laboratory of Neuroscience and Molecular Pharmacology, Institute of Translational Biomedicine, Saint Petersburg State University, Russian Federation.
Evgeny
E
Blagovechtchenski
Centre for Cognition and Decision Making, National Research University Higher School of Economics, Russian Federation; Research Center of Neurology, Moscow, Russian Federation.
Maria
M
Nazarova
Centre for Cognition and Decision Making, National Research University Higher School of Economics, Russian Federation.
Zafer
Z
Iscan
Centre for Cognition and Decision Making, National Research University Higher School of Economics, Russian Federation.
Victoria
V
Moiseeva
Centre for Cognition and Decision Making, National Research University Higher School of Economics, Russian Federation; Neurophysics Group, Department of Neurology, Charité - University Medicine Berlin, Germany.
Vadim V
VV
Nikulin
D000328:Adult; D000513:Alpha Rhythm / Q000502:physiology*; D004569:Electroencephalography; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D006225:Hand / Q000502:physiology; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology; D013997:Time Factors; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult
EEG; TMS; motor cortex; neuronal dynamics; neuronal oscillations; variability