Multisystem Langerhans Cell Histiocytosis in Adults Revealed by Skin Lesions.
A 37-year-old woman with no remarkable medical or family history presented with papules and vesicles on an erythematous background involving the neck, sacrum, and folds (postauricular, axillary, inguinal, and under the breasts) (Figure 1). During the previous year, she was treated with local and systemic antifungals without improvement. Her history included a secondary amenorrhea, polydipsia, and polyuria (6 L/d) that started 2 years prior. Physical examination revealed chronic bilateral purulent otorrhea with thick eardrums. Histologic examination of skin biopsy revealed a highly suggestive appearance of multisystem Langerhans cell histiocytosis (LCH) with immunohistochemistry (anti-PS100 and anti-CD1a), which were positive (Figure 2A and 2B). Pituitary magnetic resonance imaging showed a thickening of the pituitary stalk in relation to a location histiocytic (Figure 3). Bone gaps were objectified on two radiographic tibial diaphyseal. Results from computed tomography (CT) scan showed a magma coelio mesenteric, axillary, and inguinal lymph nodes.
Department of Dermatology, Hospital Arrazi, CHU Mohamed VI, Marrakech, Morocco.|Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco; hananeatarguine@hotmail.fr.
Hanane
H
Atarguine
Department of Dermatology, Hospital Arrazi, CHU Mohamed VI, Marrakech, Morocco.|Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
Ouafa
O
Hocar
Department of Dermatology, Hospital Arrazi, CHU Mohamed VI, Marrakech, Morocco.|Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
Samia
S
Oussmane
Department of Dermatology, Hospital Arrazi, CHU Mohamed VI, Marrakech, Morocco.|Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
Sara Batoul
SB
Mouafik
Laboratory "Zohor" of Pathological Anatomy and Cytology, Marrakech, Morocco.
Abderrachid
A
Hamdaoui
Department of Hematology, CHU Mohamed VI, Marrakech, Morocco.
Hanan
H
Hafiane
Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.|Department of Medical Oncology, CHU Mohamed VI, Marrakech, Morocco.
Rhizlane
R
Belbaraka
Department of Dermatology, Hospital Arrazi, CHU Mohamed VI, Marrakech, Morocco.|Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
Nadia
N
Akhdari
Department of Dermatology, Hospital Arrazi, CHU Mohamed VI, Marrakech, Morocco.|Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
Said
S
Amal
D000328:Adult; D001706:Biopsy; D001847:Bone Diseases / Q000000981:diagnostic imaging; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D010031:Otitis / Q000473:pathology; D010902:Pituitary Gland / Q000000981:diagnostic imaging / Q000473:pathology; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed