A MYCN-MRN complex axis controls replication stress for the safe expansion of neuroprogenitor cells.
DNA replication must be tightly regulated to ensure accurate duplication of the genome and its transfer to the daughter cells. When these regulatory mechanisms fail, replicative stress and DNA damage ensue, eventually leading to cell cycle inhibition or cell death. We have recently uncovered that MYCN-dependent expansion of neuroprogenitor cells is accompanied by replication stress, which is restrained by the MRN complex, a direct transcriptional target of the MYCN proto-oncogene.
Dept. Molecular Medicine, University La Sapienza , Rome.
Marialaura
M
Petroni
Istituto Pasteur-Fondazione Cenci Bolognetti, Dept. Molecular Medicine, University La Sapienza , Rome, Italy.
Giuseppe
G
Giannini
DNA damage response; DNA replication; MRN complex; N-myc; Neuroprogenitor cells; Replication stress; microcephaly; proto-oncogene