Circulating endothelium-enriched microRNA-126 as a potential biomarker for coronary artery disease in type 2 diabetes mellitus patients.
Circulating microRNAs (miRNAs) have been shown as promising biomarkers for various diseases. We investigated the predictive potential of circulating endothelium-enriched miR-126 in type 2 diabetes patients (T2D) without chronic complications and T2D patients with coronary artery diseases (CAD). The expression levels of circulating miR-126, determined by quantitative real time PCR, were decrease in peripheral blood of T2D patients and T2D with CAD compared with healthy controls. MiR-126 strongly associated with T2D and CAD, negatively correlated with LDL in CAD patients and differentiated between T2D patients, T2D patients with CAD and healthy subjects. Circulating miR-126 may serve as a biomarker for predicting patients with T2D and diabetic CAD.
a College of Medicine and Medical Sciences , Arabian Gulf University , Manama , Kingdom of Bahrain.
Ghada
G
Al-Kafaji
b Diabetes and Endocrinology Clinic , Salmaniya Medical Complex , Manama , Kingdom of Bahrain.
Ghazi
G
Al-Mahroos
a College of Medicine and Medical Sciences , Arabian Gulf University , Manama , Kingdom of Bahrain.
Haifa
H
Abdulla Al-Muhtaresh
a College of Medicine and Medical Sciences , Arabian Gulf University , Manama , Kingdom of Bahrain.
Mohamed Abdalla
MA
Sabry
a College of Medicine and Medical Sciences , Arabian Gulf University , Manama , Kingdom of Bahrain.
Rima
R
Abdul Razzak
a College of Medicine and Medical Sciences , Arabian Gulf University , Manama , Kingdom of Bahrain.
Abdel Halim
AH
Salem
D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D048909:Diabetes Complications / Q000097:blood / Q000175:diagnosis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D004727:Endothelium; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged
D015415:Biomarkers; C527111:MIRN126 microRNA, human; D035683:MicroRNAs
Biomarker; circulating miR-126; coronary artery disease; microRNAs; type 2 diabetes