Microbial peptide de-coppers mitochondria: implications for Wilson disease.
The severe liver pathology of untreated Wilson disease (WD) is associated with massive copper overload caused by mutations in a liver-specific copper-transporting ATPase, ATP7B. While early, presymptomatic detection and chelation with conventional copper-binding molecules enables effective and life-saving treatment, liver transplantation is the sole option currently available for those with advanced disease. In this issue of the JCI, Lichtmannegger, Leitzinger, and colleagues delineate the therapeutic effect of methanobactin (MB), a potent bacterial copper-binding protein, at three late stages of disease in a WD rat model. Their results suggest that a formal clinical trial of MB in human subjects with severe hepatic pathology caused by WD would be rational.
Stephen G
SG
Kaler
D000251:Adenosine Triphosphatases / Q000737:chemistry; D000818:Animals; D027682:Cation Transport Proteins / Q000737:chemistry; D003300:Copper; D000073840:Copper-Transporting ATPases; D006527:Hepatolenticular Degeneration; D006801:Humans; D008928:Mitochondria; D051381:Rats
D027682:Cation Transport Proteins; D003300:Copper; D000251:Adenosine Triphosphatases; D000073840:Copper-Transporting ATPases