Carbon Dots Embedded Magnetic Nanoparticles @Chitosan @Metal Organic Framework as a Nanoprobe for pH Sensitive Targeted Anticancer Drug Delivery.
Recently, nanoscale metal organic frameworks (NMOFs) have been demonstrated as a promising carrier for drug delivery, as they possess many advantages like large surface area, high porosity, and tunable functionality. However, there are no reports about the functionalization of NMOFs, which combines cancer-targeted drug delivery/imaging, magnetic property, high drug loading content, and pH-sensitive drug release into one system. Existing formulations for integrating target molecules into NMOF are based on multistep synthetic processes. However, in this study, we report an approach that combines NMOF (IRMOF-3) synthesis and target molecule (Folic acid) encapsulation on the surface of chitosan modified magnetic nanoparticles in a single step. A noticeable feature of chitosan is control and pH responsive drug release for several days. More importantly, doxorubicin (DOX) was incorporated into magnetic NMOF formulation and showed high drug loading (1.63 g DOX g(-1) magnetic NMOFs). To demonstrate the optical imaging, carbon dots (CDs) are encapsulated into the synthesized magnetic NMOF, thereby endowing fluorescence features to the nanoparticles. These folate targeted magnetic NMOF possess more specific cellular internalization toward folate-overexpressed cancer (HeLa) cells in comparison to normal (L929) cells.
Department of Applied Chemistry, Indian School of Mines , Dhanbad 826 004, Jharkhand India.
Angshuman Ray
AR
Chowdhuri
Department of Biotechnology, Indian Institute of Technology , Kharagpur 721 302, West Bengal India.
Tanya
T
Singh
Department of Biotechnology, Indian Institute of Technology , Kharagpur 721 302, West Bengal India.
Sudip Kumar
SK
Ghosh
Department of Applied Chemistry, Indian School of Mines , Dhanbad 826 004, Jharkhand India.
Sumanta Kumar
SK
Sahu
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002244:Carbon / Q000737:chemistry*; D002460:Cell Line; D048271:Chitosan / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D000073396:Metal-Organic Frameworks / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D000073396:Metal-Organic Frameworks; D002244:Carbon; D004317:Doxorubicin; D048271:Chitosan
carboxymethyl chitosan; fluorescent carbon dots; folic acid; magnetic nanoscale metal organic framework; pH responsive doxorubicin release