Group I Metabotropic Glutamate Receptor Interacting Proteins: Fine-Tuning Receptor Functions in Health and Disease.
Group I metabotropic glutamate receptors mediate slow excitatory neurotransmission in the central nervous system and are critical to activity-dependent synaptic plasticity, a cellular substrate of learning and memory. Dysregulated receptor signaling is implicated in neuropsychiatric conditions ranging from neurodevelopmental to neurodegenerative disorders. Importantly, group I metabotropic glutamate receptor signaling functions can be modulated by interacting proteins that mediate receptor trafficking, expression and coupling efficiency to signaling effectors. These interactions afford cell- or pathway-specific modulation to fine-tune receptor function, thus representing a potential target for pharmacological interventions in pathological conditions.
Magdalena
M
Kalinowska
Dominick P. Purpura Department of Neuroscience, Rose F. Kennedy Center, Room 706, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. anna.francesconi@einstein.yu.edu.
Anna
A
Francesconi
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology*; D010146:Pain / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*
D018094:Receptors, Metabotropic Glutamate