Depression screening using health questionnaires in patients receiving oral isotretinoin for acne vulgaris.
Isotretinoin is used to treat severe and recalcitrant acne. Possible side effects include depression, suicide, and suicidal ideation; however, other studies suggest isotretinoin may improve mood and quality of life. Although iPLEDGE consenting warns about the risk of depression and suicidal ideation, there is no recommendation for screening tools. The patient health questionnaire-2 and the patient health questionnaire-9 are validated instruments that enable dermatologists to efficiently screen for depression before and after isotretinoin is initiated.
Northeast Ohio Medical University, Rootstown, Ohio. Electronic address: kschrom@neomed.edu.
Kory
K
Schrom
Akron Dermatology, Akron, Ohio.
Terri
T
Nagy
Northeast Ohio Medical University, Rootstown, Ohio; Akron Dermatology, Akron, Ohio.
Eliot
E
Mostow
D000152:Acne Vulgaris / Q000188:drug therapy; D000284:Administration, Oral; D003863:Depression / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D059020:Suicidal Ideation; D011795:Surveys and Questionnaires
D015474:Isotretinoin
depression; iPLEDGE; isotretinoin; patient health questionnaire-2; patient health questionnaire-9; screening; suicidal ideation