Antiplatelet and Antithrombotic Effects of the Extract ofLindera obtusilobaLeaves.
Lindera obtusilobahas been used in traditional herbal medicine for the treatment of blood stasis and inflammation. The leaves ofLindera obtusilobahave been reported to exhibit various physiological activities. However, there is little information available on their antiplatelet and antithrombotic activities. Thus, the present study aimed to evaluate the effect ofLindera obtusilobaleaf extract (LLE) on platelet activities, coagulation and thromboembolism. In a platelet aggregation study, LLE significantly inhibited various agonist-induced platelet aggregationsin vitroandex vivo. Furthermore, LLE significantly inhibited collagen-induced thromboxane A2 (TXA2) production in rat platelets. In addition, oral administration of LLE was protective in a mouse model of pulmonary thromboembolism induced by intravenous injection of a mixture of collagen and epinephrine. Interestingly, LLE did not significantly alter prothrombin time (PT) and activated partial thromboplastin time (aPTT). This study indicates that the antithrombotic effects of LLE might be due to its antiplatelet activities rather than anticoagulation. Taken together, these results suggest that LLE may be a candidate preventive and therapeutic agent in cardiovascular diseases associated with platelet hyperactivity.
Research and Development Center, Han Wha Pharma. Co., Ltd., Chuncheon 24468, Republic of Korea.
Jun Ho
JH
Kim
Research Center, Yang Ji Chemical, Suwon 16229, Republic of Korea.
Jaemin
J
Lee
Research and Development Center, Han Wha Pharma. Co., Ltd., Chuncheon 24468, Republic of Korea.
Soouk
S
Kang
Research Center, Yang Ji Chemical, Suwon 16229, Republic of Korea.
Hongsik
H
Moon
Research and Development Center, Han Wha Pharma. Co., Ltd., Chuncheon 24468, Republic of Korea.
Kyung Ho
KH
Chung
Research and Development Center, Han Wha Pharma. Co., Ltd., Chuncheon 24468, Republic of Korea.
Kyoung Rak
KR
Kim
Lindera obtusiloba; Platelet aggregation; Thrombosis; Thromboxane