Mortality Among Adults With Intellectual Disability in England: Comparisons With the General Population.
To describe mortality among adults with intellectual disability in England in comparison with the general population.



We conducted a cohort study from 2009 to 2013 using data from 343 general practices. Adults with intellectual disability (n = 16 666; 656 deaths) were compared with age-, gender-, and practice-matched controls (n = 113 562; 1358 deaths).



Adults with intellectual disability had higher mortality rates than controls (hazard ratio [HR] = 3.6; 95% confidence interval [CI] = 3.3, 3.9). This risk remained high after adjustment for comorbidity, smoking, and deprivation (HR = 3.1; 95% CI = 2.7, 3.4); it was even higher among adults with intellectual disability and Down syndrome or epilepsy. A total of 37.0% of all deaths among adults with intellectual disability were classified as being amenable to health care intervention, compared with 22.5% in the general population (HR = 5.9; 95% CI = 5.1, 6.8).



Mortality among adults with intellectual disability is markedly elevated in comparison with the general population, with more than a third of deaths potentially amenable to health care interventions. This mortality disparity suggests the need to improve access to, and quality of, health care among people with intellectual disability.
At the time of the study, Fay J. Hosking, Iain M. Carey, Sunil M. Shah, Tess Harris, Stephen DeWilde, and Derek G. Cook were with the Population Health Research Institute, St George's University of London, London, England. Carole Beighton was with the Faculty of Heath Social Care and Education, Kingston and St George's, University of London.
Fay J
FJ
Hosking
At the time of the study, Fay J. Hosking, Iain M. Carey, Sunil M. Shah, Tess Harris, Stephen DeWilde, and Derek G. Cook were with the Population Health Research Institute, St George's University of London, London, England. Carole Beighton was with the Faculty of Heath Social Care and Education, Kingston and St George's, University of London.
Iain M
IM
Carey
At the time of the study, Fay J. Hosking, Iain M. Carey, Sunil M. Shah, Tess Harris, Stephen DeWilde, and Derek G. Cook were with the Population Health Research Institute, St George's University of London, London, England. Carole Beighton was with the Faculty of Heath Social Care and Education, Kingston and St George's, University of London.
Sunil M
SM
Shah
At the time of the study, Fay J. Hosking, Iain M. Carey, Sunil M. Shah, Tess Harris, Stephen DeWilde, and Derek G. Cook were with the Population Health Research Institute, St George's University of London, London, England. Carole Beighton was with the Faculty of Heath Social Care and Education, Kingston and St George's, University of London.
Tess
T
Harris
At the time of the study, Fay J. Hosking, Iain M. Carey, Sunil M. Shah, Tess Harris, Stephen DeWilde, and Derek G. Cook were with the Population Health Research Institute, St George's University of London, London, England. Carole Beighton was with the Faculty of Heath Social Care and Education, Kingston and St George's, University of London.
Stephen
S
DeWilde
At the time of the study, Fay J. Hosking, Iain M. Carey, Sunil M. Shah, Tess Harris, Stephen DeWilde, and Derek G. Cook were with the Population Health Research Institute, St George's University of London, London, England. Carole Beighton was with the Faculty of Heath Social Care and Education, Kingston and St George's, University of London.
Carole
C
Beighton
At the time of the study, Fay J. Hosking, Iain M. Carey, Sunil M. Shah, Tess Harris, Stephen DeWilde, and Derek G. Cook were with the Population Health Research Institute, St George's University of London, London, England. Carole Beighton was with the Faculty of Heath Social Care and Education, Kingston and St George's, University of London.
Derek G
DG
Cook
D000293:Adolescent; D000328:Adult; D000067877:Autism Spectrum Disorder / Q000401:mortality; D002423:Cause of Death; D015897:Comorbidity; D004314:Down Syndrome / Q000401:mortality; D004739:England / Q000453:epidemiology; D004827:Epilepsy / Q000401:mortality; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D061213:Mortality, Premature; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult