Presence of Additional Cytogenetic Abnormality of t(1;15) at Diagnosis of Chronic Myelogenous Leukemia-Chronic Phase.
At diagnosis, fewer than 10% of chronic myelogenous leukemia (CML) patients have additional cytogenetic abnormalities (ACAs), which are frequently found in transformation to blast crisis. We report a case of CML-chronic phase (CML-CP) that showed t(1;15) at diagnosis. A 64-year-old man presented with sustained leukocytosis and thrombocytosis. His bone marrow (BM) was hypercellular with 2.5% blasts and BCR-ABL1 rearrangement. The karyotype in the BM was 46,XY,t(1;15)(q32;p13),t(9;22)(q34;q11.2)[20], while the karyotype in the peripheral blood was 46,XY[20]. This is the first report on the presence of t(1;15) at diagnosis of CML-CP, and its clinical significance remains unclear.
Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
Misuk
M
Ji
Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea dearmina@hanmail.net.
Mina
M
Hur
Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
Hyeong Nyeon
HN
Kim
Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
Hee-Won
HW
Moon
Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
Yeo-Min
YM
Yun
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
Sung-Yong
SY
Kim
Seoul Clinical Laboratories, Seoul Medical Science Institute, Yongin, Korea.
Sung-Hee
SH
Han
D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
additional cytogenetic abnormality; chronic myelogenous leukemia; chronic phase; diagnosis; t(1; 15)