Autophagy, a double-edged sword in hepatocarcinogenesis.
Autophagy has opposite effects on hepatocarcinogenesis depending on whether it occurs before or after its onset. Autophagy prevents the initiation of hepatocarcinogenesis by suppressing oxidative stress and DNA damage. However, it also inhibits cell death and the expression of tumor suppressors to promote tumor progression once hepatocarcinogenesis has been initiated.
Department of Molecular Microbiology and Immunology; University of Southern California Keck School of Medicine ; Los Angeles, CA, USA.
Yongjun
Y
Tian
Department of Molecular Microbiology and Immunology; University of Southern California Keck School of Medicine ; Los Angeles, CA, USA.
Linya
L
Wang
Department of Molecular Microbiology and Immunology; University of Southern California Keck School of Medicine ; Los Angeles, CA, USA.
Jing-Hsiung James
JH
Ou
autophagy; hepatocarcinogenesis; oxidative stress; tumor progression; tumor suppressors