[The Efficacy of Soluble Fibrin Monomer Complex (SFMC) for Diagnosis of Aortic Dissection (AD)].
BACKGROUND
Some biomarkers are helpful for AD diagnosis. Although many studies on efficacy of D-dimer have been reported, there are few reports about SFMC. Therefore we conducted a retrospective comparative study of efficacy of SFMC and D-dimer for diagnosis of AD.


METHODS
Nineteen patients diagnosed as AD in the emergency visit were examined. Patients with cardiopulmonary arrest on arrival were excluded. These patients were classified into three patterns as follows, Stanford A or B, terms of arriving at hospital, and closing type or patent type. The value of D-dimer and SFMC were measured at the time of the first medical examination, and comparative study of both biomarkers was carried out in each groups.


RESULTS
Background of patients were not significantly different in three studies. SFMC and D-dimer showed no significant difference between Stanford A and B. Short-terms SFMC is significantly higher than long-terms. But D-dimer showed no significant difference in each comparison. Patent type of SFMC showed higher than closing type. But D-dimer showed no significant difference between patent type and closing type.


CONCLUSIONS
SFMC showed earlier response to AD than D-dimer. Measuring SFMC coupled with D-dimer is helpful for AD diagnosis.
Hiroshi
H
Kondo
Itsuo
I
Nakagawa
Shozo
S
Hidaka
Yoshinori
Y
Okada
Yoshikazu
Y
Erabi
Yoshie
Y
Kuwahara
Atsushi
A
Morio
D000368:Aged; D000784:Aortic Dissection / Q000097:blood / Q000175:diagnosis*; D001014:Aortic Aneurysm / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; C011468:fibrinmonomer