Risk factors of acute kidney injury after acute myocardial infarction.
OBJECTIVE
To study the risk factors for acute kidney injury (AKI) in-patients with acute myocardial infarction (AMI).


METHODS
A total of 1371 cases of adult in-patients with AMI in the First People's Hospital of Changzhou from January 2008 to December 2012 were retrospectively analyzed. Based on the occurrence of AKI diagnosed according to the 2012 KDIGO AKI criteria, they were divided into AKI group and non-AKI group and further into conservative treatment groups, coronary angiography (CAG) groups, and coronary artery bypass grafting (CABG) groups based on the timing of AKI occurrence, respectively. Related risk factors of AKI were analyzed by univariate and multivariate logistic regressions.


RESULTS
410 (29.9%) developed AKI. Patients with AKI had significantly increased in-hospital mortality than patients without AKI. Multivariate logistic regression analysis showed that decreased baseline eGFR, increased fasting plasma glucose (FPG), use of diuretics and Killip grade IV were independent risk factors of AKI, while increased DBP on admission was a protective factor for patients in conservative treatment group. Decreased baseline eGFR, increased FPG, use of diuretics, intraoperative hypotension and acute infection were independent risk factors of AKI for patients in the CAG group. Decreased baseline eGFR, increased FPG, use of diuretics and low cardiac output syndrome after operation were independent risk factors of AKI for patients in the CABG group.


CONCLUSIONS
AKI is a common complication and associated with increased mortality after AMI. Decreased baseline renal function, increased FPG and use of diuretics were common independent risk factors of AKI after AMI.
a Department of Nephrology , The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University , Changzhou , China.
Yan-Bei
YB
Sun
b Department of Nephrology , Zhongda Hospital affiliated with Southeast University , Nanjing , China.
Bi-Cheng
BC
Liu
a Department of Nephrology , The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University , Changzhou , China.
Yun
Y
Zou
a Department of Nephrology , The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University , Changzhou , China.
Jia-Rong
JR
Pan
a Department of Nephrology , The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University , Changzhou , China.
Yuan
Y
Tao
a Department of Nephrology , The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University , Changzhou , China.
Min
M
Yang
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D000368:Aged; D002681:China / Q000453:epidemiology; D017023:Coronary Angiography; D004562:Electrocardiography; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D015994:Incidence; D008297:Male; D009203:Myocardial Infarction / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends
Acute kidney injury; acute myocardial infarction; mortality; prevalence; risk factors