Influence of ApoB100 3' hypervariable repeats on acute myocardial infarction.
OBJECTIVE
The 3' flanking region of apolipoprotein B (ApoB) 100 gene is known to contain short A+T-rich DNA sequences which are hypervariable in nature and called the variable number of tandem repeats (VNTRs). It results in different alleles of ApoB100. The present study extends the investigation of whether there is a correlation between the presence of these alleles and acute myocardial infarction (MI).


METHODS
We examined ApoB genotypes in 230 acute MI patients and 300 healthy controls. PCR based genotyping was done for ApoB 3' VNTRs.


RESULTS
We recoded 3'ApoB-VNTR alleles through three- and five-allelic models based on different sizes and found that large repeats (>37) were significantly associated with acute MI (p<0.0001). These large repeats (>37) were also significantly associated with higher lipid levels in the MI group.


CONCLUSIONS
Patients with 3'ApoB-VNTR large repeats (>37) are more susceptible to acute MI development.
Department of Cardiology , Sanjay Gandhi Post Graduate Institute of Medical Sciences , Lucknow, Uttar Pradesh , India.
Neha
N
Singh
Sahara Hospital , Department of Cardiology, Lucknow, Uttar Pradesh , India.
Nakul
N
Sinha
Department of Cardiology , Sanjay Gandhi Post Graduate Institute of Medical Sciences , Lucknow, Uttar Pradesh , India.
Sudeep
S
Kumar
Department of Biostatistics and Health Informatics , Sanjay Gandhi Post Graduate Institute of Medical Sciences , Lucknow, Uttar Pradesh , India.
Chandra M
CM
Pandey
Department of Medical Genetics , Sanjay Gandhi Post Graduate Institute of Medical Sciences , Lucknow, Uttar Pradesh , India.
Suraksha
S
Agrawal