Hypotensive Activity of Ethanolic Extracts of Morinda citrifolia L. Leaves and Fruit in Dexamethasone-Induced Hypertensive Rat.
The effect of ethanolic extract of Morinda citrifolia leaves and fruit on blood pressure in dexamethasone-induced hypertension rat was evaluated. Total phenolic content of Morinda citrifolia leaves ethanolic extract (MCLEE) and Morinda citrifolia leaves ethanolic extract (MCFEE) was 1.789 ± 0.116 and 1.677 ± 0.051 mg of gallic acid equivalents per gram sample, respectively. Rutin level in MCLEE was 0.92 ± 0.19%, and scopoletin level in MCFEE was 0.46 ± 0.05%. MCLEE, MCFEE, and its extract combination significantly decreased the blood pressure of hypertensive rats. The combination group showed highest hypotensive activity by lowering systolic blood pressure by 16.71 ± 3.95%, diastolic blood pressure by 21.49 ± 7.90%, and mean arterial blood pressure by 19.58% ± 6.35. All extract treatments have not been able to repair or inhibit renal damage caused by dexamethasone induction.
Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.|STIFAR Yayasan Farmasi, Semarang, Indonesia.
Dyan
D
Wigati
Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.|Universitas Lambung Mangkurat, Banjarmasin, Indonesia.
Khoerul
K
Anwar
Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Sudarsono
Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia agungendronugroho@gmail.com.
Agung Endro
AE
Nugroho
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003907:Dexamethasone / Q000009:adverse effects; D004195:Disease Models, Animal; D000431:Ethanol; D005638:Fruit / Q000737:chemistry*; D006973:Hypertension / Q000188:drug therapy*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D032066:Morinda; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012603:Scopoletin; D013950:Thymus Gland / Q000187:drug effects
D010936:Plant Extracts; D000431:Ethanol; D003907:Dexamethasone; D012603:Scopoletin
Morinda citrifolia L; dexamethasone; hypotensive; renal rat; rutin; scopoletin