Does radiation-induced c-MYC amplification initiate breast oncogenesis?
The MYC (v-myc avian myelocytomatosis viral oncogene homolog; c-MYC) locus on chromosome 8q is susceptible to high-level amplification following exposure of human breast cells to ionizing radiation, and c-MYC amplification is a common feature of both radiogenic adenocarcinoma and radiogenic angiosarcoma of the breast. Taken together, these observations suggest common breast-specific susceptibility factors that predispose cells to amplification of this critical proto-oncogene and the development of radiogenic cancer in multiple tissue types of this radiosensitive organ.
Northern Institute for Cancer Research; Newcastle University ; Newcastle upon Tyne, UK.
Mark A
MA
Wade
Northern Institute for Cancer Research; Newcastle University ; Newcastle upon Tyne, UK.
Felicity E B
FE
May
Department of Pediatrics; University of Chicago ; Chicago, IL USA.
Ken
K
Onel
Northern Institute for Cancer Research; Newcastle University ; Newcastle upon Tyne, UK.
James M
JM
Allan
MYC; adenocarcinoma; amplification; oncogene; radiosensitive