The great migration of Bax and Bak.
The Bcl-2 proteins Bcl-2-associated X protein (Bax) and Bcl-2 antagonist killer 1 (Bak) can commit cells to apoptosis. Retrotranslocation of Bax from the mitochondria into the cytosol is essential for cell survival. Recently, we reported that Bak is also present in the cytosol of healthy cells and that Bax and Bak are regulated by the same retrotranslocation process.
Institute for Biochemistry and Molecular Biology; University of Freiburg; Freiburg, Germany; BIOSS; Center for Biological Signaling Studies; University of Freiburg; Freiburg, Germany; Spemann Graduate School of Biology and Medicine; SGBM; Freiburg, Germany.
Frank
F
Edlich
mitochondrial apoptosis/Bcl-2 proteins