Osteosarcoma of head and neck: A retrospective study on prognostic factors from a single institute database.
Osteosarcoma is a common bone malignancy occurring infrequently in head and neck region, the NCDB database of osteosarcoma suggests that the survival and prognosis of the head and neck osteosarcomas lie midway among other sites of occurrence, poorest survival is pelvic region and best is upper extremity. The influence of other prognostic factors independently effecting survival and recurrence are not studied widely because of scarce data even in databases. More over; these database are underrepresent eastern population. The authors institute treated around 160 head and neck osteosarcomas (HNOS) from 2007 to 2013 which were evaluated retrospectively for prognostic factors effecting survival and recurrence in specific population.



The historical records of patients treated for head and neck osteosarcomas from 2007 to 2013 were charted. The clinical and pathological factors affecting the local recurrence (LR), overall survival (OS), disease free survival (DFS), metastasis (MT) were analyzed in univariate and multivariate cox regression model for survival.



A total of 160 HNOS patients were treated in the given time period, and 137 patients with follow up were analyzed. The median period of follow up was 3.067±0.356years for the alive patients. In the multivariate cox regression model for OS; surgical margin (p=0.000) was most significant, histological grade was borderline (p=0.062). For LR: surgical margin (p=0.002), histological subtype (p=0.048) and histological grade (p=0.024). For MT; surgical margin (p=0.000) was the significant factor.



Histological grade and unclear margins are the significant independent prognostic factors effecting disease outcome of HNOS.
Department of Oral and Maxillofacial - Head and Neck Oncology, Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University, China. Electronic address: chenyimingchenyiming@foxmail.com.
YiMing
Y
Chen
Medical record office, Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University, China. Electronic address: bss106@126.com.
Qingcheng
Q
Shen
Department of Oral and Maxillofacial - Head and Neck Oncology, Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University, China. Electronic address: sandhyagokavarapu@gmail.com.
Sandhya
S
Gokavarapu
Department of Oral and Maxillofacial - Head and Neck Oncology, Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University, China. Electronic address: 847489253@qq.com.
Chengzhong
C
Lin
Department of Oral and Maxillofacial - Head and Neck Oncology, Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University, China. Electronic address: dr_adzwin@yahoo.com.
Yahiya
Department of Oral and Maxillofacial - Head and Neck Oncology, Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University, China. Electronic address: caowei561521@hotmail.com.
Wei
W
Cao
Department of Oral and Maxillofacial - Head and Neck Oncology, Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University, China. Electronic address: drshubhra@yahoo.co.in.
Shubhra
S
Chauhan
Department of Oral and Maxillofacial - Head and Neck Oncology, Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University, China. Electronic address: lzq-falali@hotmail.com.
Zheqi
Z
Liu
Department of Oral and Maxillofacial - Head and Neck Oncology, Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University, China. Electronic address: Jitongjitong@foxmail.com.
Tong
T
Ji
Department of Oral Pathology, Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University, China. Electronic address: tian0304_cn@163.com.
Zhen
Z
Tian
D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D009364:Neoplasm Recurrence, Local; D012516:Osteosarcoma / Q000175:diagnosis* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies
Head and neck osteosarcoma (HNOS); Osteosarcoma; Prognosis; Survival