Addictive drugs, arrhythmias, and cardiac inward rectifiers.
In many addictive drugs including alcohol and nicotine, proarrhythmic effects were reported. This review provides an overview of the current knowledge in this field (with a focus on the inward rectifier potassium currents) to promote the lacking data and appeal for their completion, thus, to improve understanding of the proarrhythmic potential of addictive drugs.
Markéta
M
Bébarová
Zuzana
Z
Horáková
Roman
R
Kula
D000200:Action Potentials; D000428:Alcohol Drinking / Q000009:adverse effects*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D000431:Ethanol / Q000009:adverse effects*; D006329:Heart Conduction System / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D009538:Nicotine / Q000009:adverse effects*; D018722:Nicotinic Agonists / Q000009:adverse effects*; D011188:Potassium / Q000378:metabolism*; D024661:Potassium Channels, Inwardly Rectifying / Q000187:drug effects* / Q000378:metabolism; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*
D018722:Nicotinic Agonists; D024661:Potassium Channels, Inwardly Rectifying; D000431:Ethanol; D009538:Nicotine; D011188:Potassium
Addictive drug; Arrhythmias; Ethanol; Inward rectifier; Nicotine