Antihyperglycemic activity of Albizzia lebbeck bark extract in streptozotocin-nicotinamide induced type II diabetes mellitus rats.
BACKGROUND
Albizzia lebbeck (L.) Benth. (Family - Leguminosae) extract is a proven mast cell stabilizing agent. Mast cells are involved in the inflammatory processes leading to the diabetes mellitus.


OBJECTIVE
To evaluate the effect of A. lebbeck against experimentally induced type 2 diabetes mellitus in rats.


METHODS
Female Sprague-Dawley rats were randomly allocated to six groups (n = 6). Diabetes was induced by single intraperitoneal injection of streptozotocin (50 mg/kg) given after 15 min of nicotinamide administration (110 mg/kg). Treatment with methanolic extract of A. lebbeck bark (MEAL) and metformin drug as standard was given for 21 days. Serum glucose (GLU) levels were measured on the 0 day and on 1(st), 7(th), 14(th) and 21(st) day after diabetes induction. After completion of study period, various biochemical parameters in serum such as - GLU, lipid profile, urea and creatinine were estimated. One-way analysis of variance followed with post-hoc Dunnett's test was used to analyse the data. Statistical significance for the values was set at P< 0.05.


RESULTS
MEAL significantly decreased the level of serum GLU, creatinine, urea, cholesterol, triglycerides, low-density lipoprotein-cholesterol, very low-density lipoprotein-cholesterol and increased high-density lipoprotein levels.


CONCLUSIONS
A. lebbeck bark extract showed antihyperglycaemic activity along with antihyperlipidemic effect.
Department of Pharmacology, Anand Pharmacy College, Anand, Gujarat, India.
Priyank A
PA
Patel
Department of Pharmacology, Anand Pharmacy College, Anand, Gujarat, India.
Mihir P
MP
Parikh
Department of Pharmacology, Anand Pharmacy College, Anand, Gujarat, India.
Sarika
S
Johari
Department of Pharmacology, Anand Pharmacy College, Anand, Gujarat, India.
Tejal R
TR
Gandhi
Albizzia lebbeck; mast cell stabilizer; metformin; type II diabetes mellitus