The protective effects of different treatments on rat salivary glands after radiotherapy.
This study was aimed to evaluate the efficacy of treatment modalities for minimizing salivary gland damage caused by radiotherapy. Forty rats were divided into five groups. Group 1 had no irradiation or any treatment. Group 2 underwent only 15 Gy single dose radiotherapy. N-acetylcysteine, dexamethasone, hyperbaric oxygen treatment were given, respectively to the group 3, 4 and 5 for 5 days. 15 Gy single dose radiotherapy was applied to the group 3, 4 and 5 on the second day. Pyknosis, lysis, and vacuolization were examined in ductal cells and pyknosis, lysis, vacuolization, inflammation and collective duct damage in acinar cells. Dexamethasone and hyperbaric oxygen did not prove to have a positive effect on acinar and ductal cell. N-acetylcysteine-applied group had statistically significantly lower amount of damage. We determined that the decrease of ductal and acinar cell damage in parotid glands of N-acetylcysteine-applied rats was more distinct and statistically.
Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
Murat
M
Konak
Department of Otorhinolaryngology, Medipol University, Kosuyolu/Kadiköy, 34718, Istanbul, Turkey. hakancincik1@yahoo.com.
Hakan
H
Cincik
Department of Otorhinolaryngology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
Evren
E
Erkul
Department of Pathology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
Zafer
Z
Kucukodaci
Department of Otorhinolaryngology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
Atila
A
Gungor
Department of Radiation Oncology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
Sevim
S
Ozdemir
Department of Otorhinolaryngology, Medipol University, Kosuyolu/Kadiköy, 34718, Istanbul, Turkey.
Engin
E
Cekin
Department of Oral Implantology, Istanbul University Faculty of Dentistry, Istanbul, Turkey.
Volkan
V
Arisan
Department of Underwater and Hyperbaric Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
Mesut
M
Mutluoglu
Department of Otorhinolaryngology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
Murat
M
Salihoglu
D000111:Acetylcysteine / Q000627:therapeutic use*; D000818:Animals; D003907:Dexamethasone / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006931:Hyperbaric Oxygenation; D008297:Male; D010306:Parotid Gland / Q000528:radiation effects; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011878:Radiotherapy / Q000009:adverse effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012469:Salivary Glands / Q000528:radiation effects*
D005938:Glucocorticoids; D011837:Radiation-Protective Agents; D003907:Dexamethasone; D000111:Acetylcysteine
Corticosteroid; Hyperbaric oxygen; N-acetylcysteine; Radiotherapy; Salivary glands