Modification of titanium surfaces by adding antibiotic-loaded PHB spheres and PEG for biomedical applications.
Novel researches are focused on the prevention and management of post-operative infections. To avoid this common complication of implant surgery, it is preferable to use new biomaterials with antibacterial properties. Therefore, the aim of this work is to develop a method of combining the antibacterial properties of antibiotic-loaded poly(3-hydroxybutyrate) (PHB) nano- and micro-spheres and poly(ethylene glycol) (PEG) as an antifouling agent, with titanium (Ti), as the base material for implants, in order to obtain surfaces with antibacterial activity. The Ti surfaces were linked to both PHB particles and PEG by a covalent bond. This attachment was carried out by firstly activating the surfaces with either Oxygen plasma or Sodium hydroxide. Further functionalization of the activated surfaces with different alkoxysilanes allows the reaction with PHB particles and PEG. The study confirms that the Ti surfaces achieved the antibacterial properties by combining the antibiotic-loaded PHB spheres, and PEG as an antifouling agent.
Departament de Ciència dels Materials i Enginyeria Metal·lúrgica, Laboratori de Microscòpia Electrònica, Universitat Politècnica de Catalunya-Barcelona TECH, Avda. Diagonal Pavelló E (Etseib)-Planta 0, 647-08028, Barcelona, Spain. Sandra8855@hotmail.com.
Alejandra
A
Rodríguez-Contreras
Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya-Barcelona TECH, Sant Nebridi 22, 08222, Terrassa Barcelona, Spain.
María Soledad
MS
Marqués-Calvo
Departament de Ciència dels Materials i Enginyeria Metal·lúrgica, Laboratori de Microscòpia Electrònica, Universitat Politècnica de Catalunya-Barcelona TECH, Avda. Diagonal Pavelló E (Etseib)-Planta 0, 647-08028, Barcelona, Spain.|Departament de Ciència dels Materials i Enginyeria Metal·lúrgica, Biomaterials, Biomechanics and Tissue Engineering Group, Universitat Politècnica de Catalunya-Barcelona TECH, Avda. Diagonal, 647-08028, Barcelona, Spain.|CIBER-BBN, Centro de Investigación Biomédica en Red, Madrid, Spain.
Francisco Javier
FJ
Gil
Departament de Ciència dels Materials i Enginyeria Metal·lúrgica, Laboratori de Microscòpia Electrònica, Universitat Politècnica de Catalunya-Barcelona TECH, Avda. Diagonal Pavelló E (Etseib)-Planta 0, 647-08028, Barcelona, Spain.|Departament de Ciència dels Materials i Enginyeria Metal·lúrgica, Biomaterials, Biomechanics and Tissue Engineering Group, Universitat Politècnica de Catalunya-Barcelona TECH, Avda. Diagonal, 647-08028, Barcelona, Spain.|CIBER-BBN, Centro de Investigación Biomédica en Red, Madrid, Spain.
José María
JM
Manero
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D015169:Colony Count, Microbial; D004926:Escherichia coli / Q000187:drug effects; D006885:Hydroxybutyrates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010100:Oxygen / Q000737:chemistry; D058626:Plasma Gases; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011437:Propylamines / Q000737:chemistry; D012821:Silanes / Q000737:chemistry; D013052:Spectrometry, X-Ray Emission; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D000094122:Polyhydroxybutyrates
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D006885:Hydroxybutyrates; D010100:Oxygen; D058626:Plasma Gases; D011091:Polyesters; D011092:Polyethylene Glycols; D011437:Propylamines; D012821:Silanes; D014025:Titanium; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates; C477625:amino-propyl-triethoxysilane