Cellular Distribution and Gene Expression Pattern of Metastasin (S100A4), Calgranulin A (S100A8), and Calgranulin B (S100A9) in Oral Lesions as Markers for Molecular Pathology.
The objective of this study was to analyze cellular localization and expression levels of oncologic relevant members of the S100 family in common oral lesions.Biopsies of various oral lesions were analyzed. S100A4 showed a higher expression rate in leukoplakias and oral squamous cell carcinomas. Transcript levels of S100A8 and S100A9 were significantly decreased in malignant OSCCs. A correlation could be drawn between the expression levels of these genes and the pathological characteristics of the investigated lesions. S100A4, A8, and A9 proteins represent promising marker genes to evaluate the risk potential of suspicious oral lesions in molecular pathology.
a Department of Periodontology, Operative and Preventive Dentistry , University of Bonn , Bonn , Germany.
Jan
J
Reckenbeil
b Department of Prosthodontics, Preclinical Education, and Material Science , University of Bonn , Bonn , Germany.
Dominik
D
Kraus
c Neuro- and Tumor Cell Biology Group, Department of Nuclear Medicine , University of Bonn , Bonn , Germany.
Rainer
R
Probstmeier
d Department of Dermatology and Allergy , University of Bonn , Bonn , Germany.
Jean-Pierre
JP
Allam
d Department of Dermatology and Allergy , University of Bonn , Bonn , Germany.
Natalija
N
Novak
a Department of Periodontology, Operative and Preventive Dentistry , University of Bonn , Bonn , Germany.
Matthias
M
Frentzen
e Department of Oral & Maxillofacial Plastic Surgery , University of Bonn , Bonn , Germany.
Markus
M
Martini
e Department of Oral & Maxillofacial Plastic Surgery , University of Bonn , Bonn , Germany.
Matthias
M
Wenghoefer
a Department of Periodontology, Operative and Preventive Dentistry , University of Bonn , Bonn , Germany.
Jochen
J
Winter
D015415:Biomarkers; D001706:Biopsy; D040501:Calgranulin A / Q000235:genetics* / Q000378:metabolism*; D040502:Calgranulin B / Q000235:genetics* / Q000378:metabolism*; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D042541:Intracellular Space / Q000378:metabolism; D009059:Mouth Diseases / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis; D000071999:S100 Calcium-Binding Protein A4 / Q000235:genetics* / Q000378:metabolism*; D059467:Transcriptome
D015415:Biomarkers; D040501:Calgranulin A; D040502:Calgranulin B; D000071999:S100 Calcium-Binding Protein A4
Differential gene expression; Molecular pathology; Oral lesions; S100A genes; Tumor markers