Diagnostic value of plasma and bronchoalveolar lavage samples in acute lung allograft rejection: differential cytology.
Diagnosis of acute lung allograft rejection is currently based on transbronchial lung biopsies. Additional methods to detect acute allograft dysfunction derived from plasma and bronchoalveolar lavage samples might facilitate diagnosis and ultimately improve allograft survival. This review article gives an overview of the cell profiles of bronchoalveolar lavage and plasma samples during acute lung allograft rejection. The value of these cells and changes within the pattern of differential cytology to support the diagnosis of acute lung allograft rejection is discussed. Current findings on the topic are highlighted and trends for future research are identified.
Division of Pulmonology, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Nicole E
NE
Speck
Division of Pulmonology, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Macé M
MM
Schuurmans
Division of Pulmonology, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Christian
C
Murer
Division of Pulmonology, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland.
Christian
C
Benden
Division of Pulmonology, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland. lars.huber@usz.ch.
Lars C
LC
Huber
D000208:Acute Disease; D064591:Allografts; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry* / Q000166:cytology; D006084:Graft Rejection / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D016040:Lung Transplantation / Q000009:adverse effects*; D008264:Macrophages / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis
D015415:Biomarkers
Blood; Bronchoalveolar lavage; Cytology; Diagnosis; Graft rejection; Lung transplantation; Plasma