Lipid-modifying effects of nutraceuticals: An evidence-based approach.
The present review provides an up-to-date summary of the findings on the lipid-lowering effects of the most important nutraceuticals and functional foods. Based on current knowledge, nutraceuticals might exert significant lipid-lowering, and their use has several advantages: A number of important questions remain to be addressed, including whether longer durations of therapy would result in a better response and the exact safety profile of nutraceuticals, especially at doses higher than those consumed in an average diet. Additionally, data regarding the effects of nutraceutical supplementation on the incidence of cardiovascular outcomes are lacking, and it is not clear whether additional lipid lowering by nutraceuticals can modify the residual cardiovascular risk that remains after statin therapy.
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
Amirhossein
A
Sahebkar
Department of Functional Sciences, Discipline of Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Maria-Corina
MC
Serban
Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Lodz, Poland.
Anna
A
Gluba-Brzózka
Department of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London, London, United Kingdom.
Dimitri P
DP
Mikhailidis
Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy.
Arrigo F
AF
Cicero
Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Lodz, Poland.
Jacek
J
Rysz
Department of Hypertension, Medical University of Lodz, Lodz, Poland. Electronic address: Maciejbanach@aol.co.uk.
Maciej
M
Banach
D000872:Anthocyanins / Q000627:therapeutic use; D001599:Berberine / Q000627:therapeutic use; D001688:Biological Products / Q000627:therapeutic use; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use; D004043:Dietary Fiber / Q000627:therapeutic use; D019587:Dietary Supplements; D050171:Dyslipidemias / Q000097:blood / Q000178:diet therapy / Q000188:drug therapy; D019317:Evidence-Based Medicine; D005737:Garlic; D031584:Hibiscus; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D010840:Phytosterols / Q000627:therapeutic use; D019936:Probiotics / Q000627:therapeutic use; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use
D000872:Anthocyanins; D001688:Biological Products; D004042:Dietary Fats, Unsaturated; D004043:Dietary Fiber; D000960:Hypolipidemic Agents; D008055:Lipids; D010840:Phytosterols; D013267:Stilbenes; C117343:red yeast rice; D001599:Berberine; D000077185:Resveratrol
Atherogenic dyslipidemia; Functional foods; Lipids; Nutraceuticals