miR-17-92 explains MYC oncogene addiction.
MYC regulates tumorigenesis by coordinating the expression of thousands of genes. We found that MYC appears to regulate the decisions between cell survival versus death and self-renewal versus senescence through the microRNA miR-17-92 cluster. Addiction to the MYC oncogene may therefore in fact be an addiction to miR-17-92.
Division of Oncology; Departments of Medicine and Pathology; Stanford University ; Stanford, CA USA.
Yulin
Y
Li
Division of Oncology; Departments of Medicine and Pathology; Stanford University ; Stanford, CA USA.
Stephanie C
SC
Casey
Division of Oncology; Departments of Medicine and Pathology; Stanford University ; Stanford, CA USA.
Peter S
PS
Choi
Division of Oncology; Departments of Medicine and Pathology; Stanford University ; Stanford, CA USA.
Dean W
DW
Felsher
MYC; lymphoma; microRNA miR-17-92; oncogene addiction