Damaged replication forks tolerate USP7 to maintain genome stability.
RAD18 functions to promote DNA damage tolerance (DTT), a process that ensures faithful genome duplication. Protein ubiquitylation/deubiquitylation is a critical regulatory mechanism controlling DTT. Recently, we have identified the deubiquitylating enzyme USP7 as a component of the DTT machinery that acts to protect RAD18 from proteasome-dependent degradation.
School of Cancer Sciences, University of Birmingham , Birmingham, UK.
Anastasia
A
Zlatanou
School of Cancer Sciences, University of Birmingham , Birmingham, UK.
Grant S
GS
Stewart