Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat.
Centre of Pediatrics III, Department of Hematology, Oncology and Hemostasis, Comprehensive Care Centre for Thrombosis and Hemostasis, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany.
Emel
E
Aygören-Pürsün
Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Markus
M
Magerl
Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt, Germany.
Jochen
J
Graff
Haemophilia Centre Rhine Main, Frankfurt-Mörfelden, Germany.
Inmaculada
I
Martinez-Saguer
Haemophilia Centre Rhine Main, Frankfurt-Mörfelden, Germany.
Wolfhart
W
Kreuz
Department of Immunology, Barts Health NHS Trust, London, United Kingdom.
Hilary
H
Longhurst
Department of Immunology, Barts Health NHS Trust, London, United Kingdom.
Iman
I
Nasr
HNO-Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Murat
M
Bas
HNO-Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Ulrich
U
Straßen
Pharstat Inc, Durham, NC.
Lei
L
Fang
BioCryst Pharmaceuticals Inc, Durham, NC.
Melanie
M
Cornpropst
BioCryst Pharmaceuticals Inc, Durham, NC.
Sylvia
S
Dobo
BioCryst Pharmaceuticals Inc, Durham, NC.
Phil
P
Collis
BioCryst Pharmaceuticals Inc, Durham, NC.
William P
WP
Sheridan
Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address: Marcus.Maurer@charite.de.
Marcus
M
Maurer
D000328:Adult; D054179:Angioedemas, Hereditary / Q000188:drug therapy* / Q000378:metabolism; D050718:Complement C1 Inhibitor Protein / Q000378:metabolism; D018592:Cross-Over Studies; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D020842:Plasma Kallikrein / Q000037:antagonists & inhibitors*; D011392:Proline / Q000031:analogs & derivatives* / Q000627:therapeutic use
D050718:Complement C1 Inhibitor Protein; D004791:Enzyme Inhibitors; D011392:Proline; D020842:Plasma Kallikrein; C402246:avorelin