Imaging findings in a child with calcineurin inhibitor-induced pain syndrome after bone marrow transplant for beta thalassemia major.
Calcineurin inhibitor-induced pain syndrome is an entity recognized in patients on immunosuppressive therapy after transplantation. Diagnosis is characterized by onset of pain beginning in the setting of an elevated calcineurin-inhibitor trough level. Reducing the medication dose relieves symptoms. Imaging findings can be nonspecific, including bone marrow edema and periosteal reaction. We present the unique case of calcineurin inhibitor-induced pain syndrome in a child and review the imaging findings.
Department of Radiology, Columbia University Medical Center, Morgan Stanley Children's Hospital, 3959 Broadway, CHONY 3N, New York, NY, 10032, USA. rsa2121@cumc.columbia.edu.
Rama S
RS
Ayyala
Department of Radiology, Columbia University Medical Center, Morgan Stanley Children's Hospital, 3959 Broadway, CHONY 3N, New York, NY, 10032, USA.
Staci D
SD
Arnold
Department of Radiology, Columbia University Medical Center, Morgan Stanley Children's Hospital, 3959 Broadway, CHONY 3N, New York, NY, 10032, USA.
Monica
M
Bhatia
Department of Radiology, Columbia University Medical Center, Morgan Stanley Children's Hospital, 3959 Broadway, CHONY 3N, New York, NY, 10032, USA.
Jahannaz
J
Dastgir
D018771:Arthralgia / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D016026:Bone Marrow Transplantation; D065095:Calcineurin Inhibitors / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007223:Infant; D008279:Magnetic Resonance Imaging; D013577:Syndrome; D016559:Tacrolimus / Q000009:adverse effects*; D017086:beta-Thalassemia / Q000628:therapy*
D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D016559:Tacrolimus
Bone marrow transplant; Calcineurin inhibitor-induced pain syndrome; Child; Magnetic resonance imaging; Radiography