In Silico Models for Acute Systemic Toxicity.
In this chapter, we give an overview of the regulatory requirements for acute systemic toxicity information in the European Union, and we review the availability of structure-based computational models that are available and potentially useful in the assessment of acute systemic toxicity. The most recently published literature models for acute systemic toxicity are also discussed, and perspectives for future developments in this field are offered.
Systems Toxicology Unit and EURL ECVAM, Institute for Health and Consumer Protection, Joint Research Centre, European Commission, Ispra, Varese, Italy.
Julien
J
Burton
Systems Toxicology Unit and EURL ECVAM, Institute for Health and Consumer Protection, Joint Research Centre, European Commission, Ispra, Varese, Italy. Andrew.WORTH@ec.europa.eu.
Andrew P
AP
Worth
Department of QSAR & Molecular Modeling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Ivanka
I
Tsakovska
Department of QSAR & Molecular Modeling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Antonia
A
Diukendjieva
D000826:Animal Testing Alternatives / Q000331:legislation & jurisprudence* / Q000379:methods; D000818:Animals; D003198:Computer Simulation; D005062:European Union; D006801:Humans; D021281:Quantitative Structure-Activity Relationship; D023382:Toxicity Tests, Acute / Q000379:methods*
Acute systemic toxicity; In silico model; Organ-specific toxicity; Regulation