Regulation of intestinal homeostasis and tumorigenesis by the transcriptional coregulator RIP140.
Colon cancer frequently results from mutations that constitutively activate the Wnt signaling pathway, a major target being the tumor suppressor gene adenomatous polyposis coli (APC). We recently identified the transcription factor RIP140 as a new inducer of APC gene transcription that inhibits colon cancer cell growth and impedes the Wnt signaling pathway by reducing β-catenin activation.
IRCM; Institut de Recherche en Cancérologie de Montpellier; INSERM U896; Université Montpellier1 ; Montpellier, France.
Vincent
V
Cavaillès
IRCM; Institut de Recherche en Cancérologie de Montpellier; INSERM U896; Université Montpellier1 ; Montpellier, France.
Marion
M
Lapierre
APC; RIP140; Wnt signaling; colon cancer; gut homeostasis