Copper, zinc and iron levels in premature infants following red blood cell transfusion.
This study aimed to investigate effect of erythrocyte suspension (ES) transfusion on Cu, Zn, and Fe levels. It was conducted on 53 premature infants who were admitted to Hacettepe Hospital and received EST for first time. Blood samples were drawn before and 96h after ES transfusion to determine Cu, Zn, and Fe levels in plasma and/or erythrocytes. The mean plasma Cu levels were 99±3μg/dl and 113±3μg/dl; Zn levels were 105±2μg/dl and 115±23μg/dl; mean plasma Fe level was 58.1±19.4 and 75.2±25.4μg/dl and mean erythrocyte Fe level was 4182±2314μg/ml and 7009±5228μg/ml, before and after ES transfusion. The differences between before and after ES transfusion in Cu, Zn and Fe levels were significant. Correlation between plasma and erythrocyte Fe levels was significant both before and after ES transfusion. Though Fe overload is a major cause of morbidity/mortality after ES transfusion, alterations in trace elements should also be considered when transfusing blood to infants and children.
Department of Biochemistry, Diskapi Children's Health and Diseases, Hematology, Oncology Training and Research Hospital, Ankara, Turkey.
Murat
M
Kizilgun
Hacettepe University İhsan Doğramacı Childrens' Hospital, Department of Neonatology, 06100 Ankara, Turkey.
Sahin
S
Takci
Hacettepe University, Faculty of Pharmacy, Department of Toxicology, 06100 Ankara, Turkey.
Pinar
P
Erkekoglu
Hacettepe University, Faculty of Pharmacy, Department of Toxicology, 06100 Ankara, Turkey; Atatürk University, Faculty of Pharmacy, Department of Toxicology, Erzurum, Turkey.
Ali
A
Asci
Hacettepe University, Faculty of Pharmacy, Department of Toxicology, 06100 Ankara, Turkey.
Aylin
A
Balci
Hacettepe University İhsan Doğramacı Childrens' Hospital, Department of Neonatology, 06100 Ankara, Turkey.
Sule
S
Yigit
Hacettepe University, Faculty of Pharmacy, Department of Toxicology, 06100 Ankara, Turkey. Electronic address: belmagumusel@yahoo.com.
Belma
B
Kocer-Gumusel
D003300:Copper / Q000097:blood*; D017707:Erythrocyte Transfusion; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D007235:Infant, Premature, Diseases / Q000097:blood / Q000628:therapy; D007501:Iron / Q000097:blood*; D008297:Male; D015032:Zinc / Q000097:blood*
D003300:Copper; D007501:Iron; D015032:Zinc
Copper; Iron levels; Premature infant; Red blood cell transfusion; Zinc