Wingless/β-catenin signaling as a modulator of chemoresistance in cancer.
O6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme involved in chemoresistance. We have shown that MGMT abundance is regulated by canonical Wingless (Wnt) signaling and that inhibition of Wnt signaling restores chemosensitivity in preclinical cancer models. These findings have direct therapeutic implications for the treatment of cancers with high MGMT expression.
Karolinska Institutet, Department of Women's and Children's Health, Childhood Cancer Research Unit , S-17176 Stockholm, Sweden.
John Inge
JI
Johnsen
Karolinska Institutet, Department of Women's and Children's Health, Childhood Cancer Research Unit , S-17176 Stockholm, Sweden.
Malin
M
Wickström
Department of Stem and Regenerative Biology, Harvard University, Cambridge, MA, USA; Center for Regenerative Medicine and the Cancer Center, Massachusetts General Hospital, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA.
Ninib
N
Baryawno
MGMT; chemoresistance; temozolomide; β-catenin