[The effect of cytokine therapy on the results of surgical treatment of patients with acute ulcerative gastroduodenal bleeding].
OBJECTIVE
To improve the results of surgical treatment of patients with acute ulcerative gastroduodenal bleeding using immune correction with β-leukin.


METHODS
Urgent and elective operations were performed in 120 patients with gastroduodenal ulcers. Patients of the main group (n=63) received systemic cytokine therapy with β-leukin in addition to conventional treatment. Pre- and postoperative immune correction was absent in the comparison group.


CONCLUSIONS
There was preoperative imbalance of antiphlogistic and proinflammatory cytokines in comparison group. Severity of this process depended on blood loss. Therapy with interleukin decreased severity of cytokine imbalance.
Azerbaijan Medical University, Baku.
J N
JN
Gadzhiyev
Azerbaijan Medical University, Baku.
V A
VA
Allakhverdiyev
V.T. Zaitsev Institute of General and Emergency Surgery, Academy of Medical Sciences of Ukraine, Kharkiv.
S V
SV
Sushkov
V.T. Zaitsev Institute of General and Emergency Surgery, Academy of Medical Sciences of Ukraine, Kharkiv.
E M
EM
Klimova
Azerbaijan Medical University, Baku.
N J
NJ
Gadzhiyev
D000293:Adolescent; D000328:Adult; D000368:Aged; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006488:Hemostasis, Surgical / Q000009:adverse effects / Q000379:methods; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage / Q000276:immunology; D053583:Interleukin-1beta / Q000008:administration & dosage / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications*; D010438:Peptic Ulcer Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000276:immunology / Q000601:surgery; D011183:Postoperative Complications / Q000276:immunology / Q000517:prevention & control; D011184:Postoperative Period; D016896:Treatment Outcome
D007155:Immunologic Factors; D053583:Interleukin-1beta