Preliminary findings on biomarker levels from extracerebral sources in patients undergoing trauma surgery: Potential implications for TBI outcome studies.
Despite several experimental studies on the role of S100B and NSE in fractures, no studies on the influence of surgery on the biomarker serum levels have been performed yet.



The serum levels of S100B and NSE were analysed in patients with fractures that were located in the spine (group 1, n = 35) or in the lower extremity (group 2, n = 32) pre- and post-operatively.



The mean S100B serum level showed a significant increase (p = 0.04) post-surgery in the patients of group 1. In patients undergoing acute surgery (< 24 hours) the mean S100B serum level was 0.23 ± 0.22 μg L(-1) pre-operatively and 1.24 ± 1.38 μg L(-1) post-operatively. Likewise, the mean S100B serum level significantly increased in group 2 after surgery (p < 0.0001). In this group patients undergoing acute surgery showed a mean S100B serum level of 0.23 ± 0.14 μg L(-1) and 1.11 ± 0.73 μg L(-1) pre- and post-operatively.



This study demonstrates significant alterations of the biomarker S100B serum levels in patients undergoing surgery. Higher S100B serum levels were found within 24 hours and might be related to the acute fracture. The NSE serum levels were unchanged and this biomarker may offer the probability to serve as a future outcome predictor in studies with patients with traumatic brain injury and additional extracerebral injuries.
a Department for Trauma Surgery , Medical University of Vienna , Vienna , Austria.|b Faculty of Health Care and Social Work, Department of Public Health , University of Trnava , Slovakia.|c INRO (International Neurotrauma Research Organisation) , Vienna , Austria.
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H
Wolf
b Faculty of Health Care and Social Work, Department of Public Health , University of Trnava , Slovakia.|d Department for Medical Statistics , Medical University of Vienna , Vienna , Austria.
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C
Krall
a Department for Trauma Surgery , Medical University of Vienna , Vienna , Austria.
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G
Pajenda
a Department for Trauma Surgery , Medical University of Vienna , Vienna , Austria.
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Hajdu
a Department for Trauma Surgery , Medical University of Vienna , Vienna , Austria.
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Widhalm
a Department for Trauma Surgery , Medical University of Vienna , Vienna , Austria.
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J
Leitgeb
a Department for Trauma Surgery , Medical University of Vienna , Vienna , Austria.
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Sarahrudi
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001930:Brain Injuries / Q000097:blood* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods*; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D009418:S100 Proteins / Q000097:blood*; D016103:Spinal Fractures / Q000097:blood; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D055815:Young Adult
D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase
Clinical trials; head injury; outcome; surgery; trauma; traumatic brain injury