BMP2, a key to uncover luminal breast cancer origin linked to pollutant effects on epithelial stem cells niche.
Chronic exposure of epithelial cells to high levels of bone morphogenetic protein 2 (BMP2) has recently been demonstrated to initiate stem cell transformation toward a luminal tumor-like phenotype through a BMP2-BMPR1B-dependent mechanism. Carcinogen-driven deregulation of the stem cell niche could therefore represent a driving force to promote transformation and dictate the ultimate breast tumor subtype.
Department of Clinical Genetics; Lund University ; Lund, Sweden.
Marion
M
Chapellier
CNRS UMR5286; Center de Recherche en Cancérologie de Lyon; Lyon, France; Inserm U1052; Center de Recherche en Cancérologie de Lyon; Lyon, France; Université de Lyon;, Lyon, France; Department of Immunity, Virus and Microenvironment; Lyon, France.
Véronique
V
Maguer-Satta
BMP; BMPR1B; bisphenol; breast tumor; carcinogen; epithelial stem cell; niche; pollutant