Pyrofomins A-D, polyoxygenated sesquiterpenoids from Pyrofomes demidoffii.
Pyrofomins A-D, four polyoxygenated sesquiterpenoids have been isolated from the methanolic extract of the fruit bodies of Pyrofomes demidoffii. Their structures are elucidated by IR, HR-FTICR-MS, and 2D NMR spectroscopy. Furthermore, the cedrane carbon skeleton of pyrofomin A (1) is confirmed by X-ray crystallographic analysis. The sesquiterpenoids 1-4 show neither cytotoxicity against KB cells nor antimicrobial activity.
Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany; Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Road, Cau Giay, Hanoi, Vietnam.
Dang Ngoc
DN
Quang
Martin Luther University Halle-Wittenberg, Institute of Chemistry, Kurt-Mothes-Str. 2, 06120 Halle (Saale), Germany.
Christoph
C
Wagner
Martin Luther University Halle-Wittenberg, Institute of Chemistry, Kurt-Mothes-Str. 2, 06120 Halle (Saale), Germany.
Kurt
K
Merzweiler
Department of Microbial, Cellular and Molecular Biology, College of Natural Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Dawit
D
Abate
Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany.
Andrea
A
Porzel
Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany.
Jürgen
J
Schmidt
Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany. Electronic address: narnold@ipb-halle.de.
Norbert
N
Arnold
D045744:Cell Line, Tumor; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011124:Polyporaceae / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification
D012717:Sesquiterpenes; C000614045:pyrofomin A
Pyrofomes demidoffii; Pyrofomin; Sesquiterpenoid