Three new biphenyls from the twigs of Garcinia tetralata and their anti-tobacco mosaic virus activity.
Phytochemical investigations on the ethanol extract of the twigs of Garcinia tetralata resulted in the isolation of three new biphenyls, tetralatabiphenyls A-C (1-3), along with three known biphenyl derivatives (4-6). Structural elucidations of 1-3 were performed by spectroscopic methods such as 1D and 2D NMR spectra, in addition to high-resolution mass spectra. Compounds 1-6 were also evaluated for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compound 3 showed high anti-TMV activity with inhibition rate of 31.1%. Compounds 1, 2, and 4-6 also showed modest anti-TMV activities with inhibition rates in the range of 18.9-24.5%, respectively.
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.
Qiu-Fen
QF
Hu
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.
Yue-De
YD
Wang
b Technology Center , China Tobacco Yunnan Industry Company (Ltd.) , Kunming 650000 , China.
Dong-Lai
DL
Zhu
b Technology Center , China Tobacco Yunnan Industry Company (Ltd.) , Kunming 650000 , China.
Zhen-Hua
ZH
Yu
b Technology Center , China Tobacco Yunnan Industry Company (Ltd.) , Kunming 650000 , China.
Jian-Bo
JB
Zhan
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.
Huan-Huan
HH
Xing
b Technology Center , China Tobacco Yunnan Industry Company (Ltd.) , Kunming 650000 , China.
Hang-Ying
HY
Ma
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.
Yan
Y
Yang
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.|c College of Resource and Environment , Yuxi Normal University , Yuxi 653100 , China.
Yin-Ke
YK
Li
b Technology Center , China Tobacco Yunnan Industry Company (Ltd.) , Kunming 650000 , China.
Zhang-Yu
ZY
Chen
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education , Yunnan Minzu University , Kunming 650031 , China.
Xue-Mei
XM
Gao
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029760:Garcinia / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
D000998:Antiviral Agents; D001713:Biphenyl Compounds; C000613402:tetralatabiphenyl A; C000613404:tetralatabiphenyl B; C000613405:tetralatabiphenyl C; C010574:biphenyl
Garcinia tetralata; anti-tobacco mosaic virus activity; biphenyls; phytochemical investigations