Ras and p53: An unsuspected liaison.
The precise mechanism by which Ras proteins mediate mitogenic signaling remains obscure. We have identified the p53/p21Cip1 axis as an essential component of the Ras mitogenic pathway. Moreover, cells carrying an inactive p53/p21Cip1/Rb pathway sustain cell proliferation by inducing retroactivation of the MAPK signaling cascade in a Ras-independent manner.
Molecular Oncology Program; Centro Nacional de Investigaciones Oncológicas (CNIO) ; Madrid, Spain.
Matthias
M
Drosten
Molecular Oncology Program; Centro Nacional de Investigaciones Oncológicas (CNIO) ; Madrid, Spain.
Mariano
M
Barbacid
MAPK signaling cascade; P21; Ras; Rb; cell cycle; p53