Role of selective blocking of bradykinin receptor subtypes in attenuating allergic airway inflammation in guinea pigs.
The present study was designed to evaluate the potential role of bradykinin antagonists (R-715; bradykinin B1 receptor antagonist and icatibant; bradykinin B2 receptor antagonist) in treatment of allergic airway inflammation in comparison to dexamethasone and montelukast. R-715 as dexamethasone significantly decreased peribronchial leukocyte infiltration, bronchoalveolar lavage fluid (BALF) albumin and interleukin 1β as well as serum OVA-specific IgE level. Also, R-715 like montelukast significantly decreased BALF cell count (total and eosinophils). Icatibant showed negative results. The current findings suggest that selective bradykinin B1 receptor antagonists may have the therapeutic potential for the treatment of allergic airway inflammation.
Department of Medical Pharmacology, Faculty of Medicine, Cairo University, 11559, Egypt. Electronic address: mahammad_elkady@yahoo.com.
Mohamed M
MM
El-Kady
Department of Medical Pharmacology, Faculty of Medicine, Cairo University, 11559, Egypt. Electronic address: zarifisaak@ymail.com.
Zarif I
ZI
Girgis
Department of Medical Pharmacology, Faculty of Medicine, Cairo University, 11559, Egypt. Electronic address: dreman58@hotmail.com.
Eman A
EA
Abd El-Rasheed
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, 11559, Egypt. Electronic address: olfatshaker@yahoo.com.
Olfat
O
Shaker
Department of Medical Pharmacology, Faculty of Medicine, Cairo University, 11559, Egypt. Electronic address: drmagdyishak@yahoo.com.
Magdy I
MI
Attallah
Department of Pathology, Faculty of Medicine, Cairo University, 11559, Egypt. Electronic address: drahmedsoliman@yahoo.com.
Ahmed A
AA
Soliman
D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D065168:Bradykinin Receptor Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D018002:Receptors, Bradykinin / Q000378:metabolism*
D065168:Bradykinin Receptor Antagonists; D053583:Interleukin-1beta; C120984:R 715; D018002:Receptors, Bradykinin; D007073:Immunoglobulin E; C065679:icatibant; D010047:Ovalbumin; D001920:Bradykinin
Airway hyperresponsiveness; Asthma; Bradykinin; Bronchoalveolar lavage; Icatibant; R-715