Role of UMOD Promoter Polymorphism in the Etiology of Preeclampsia.
OBJECTIVE
To evaluate the association between preeclampsia (PE) and the single nucleotide polymorphism (SNP) rs13333226, located in the promoter region of the UMOD gene.


METHODS
A total of 1248 pregnant Han Chinese women (716 controls and 532 patients with PE) were included in this study. Genotyping of the rs13333226 polymorphism was performed by real-time PCR using a TaqMan-minor groove binder (MGB) probe assay.


RESULTS
No significant differences were detected in the allele (p = 0.62, OR = 1.08, 95% CI = 0.81-1.44) and genotype frequencies of rs13333226 (padditive = 0.38, pdominant = 0.45, precessive = 0.31) between cases and controls. When patients were divided into subgroups, no association was found with mild preeclampsia (M PE), severe preeclampsia (S PE), early onset PE, or late-onset PE. Furthermore, no significant differences were detected in the genotype and allele frequencies of rs1333226 between patients with M PE and S PE (p > 0.05) or between patients with late and early onset of the disease (p > 0.05).


CONCLUSIONS
UMOD rs13333226 does not appear to be associated with PE in Han Chinese women.
1 Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University , Jinan, China .
Ji-Peng
JP
Wan
1 Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University , Jinan, China .
Lei
L
Li
1 Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University , Jinan, China .
Hong-Yan
HY
Li
1 Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University , Jinan, China .
Fei
F
Wang
1 Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University , Jinan, China .
Xiao-Jing
XJ
Zhang
2 Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University , Jinan, China .|3 National Research Center for Assisted Reproductive Technology and Reproductive Genetics , Jinan, China .|4 The Key laboratory for Reproductive Endocrinology of Ministry of Education , Jinan, China .|5 Shandong Provincial Key Laboratory of Reproductive Medicine , Jinan, China .
Han
H
Zhao
1 Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University , Jinan, China .
Chang-Zhong
CZ
Li
1 Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University , Jinan, China .
Xie-Tong
XT
Wang
2 Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University , Jinan, China .|3 National Research Center for Assisted Reproductive Technology and Reproductive Genetics , Jinan, China .|4 The Key laboratory for Reproductive Endocrinology of Ministry of Education , Jinan, China .|5 Shandong Provincial Key Laboratory of Reproductive Medicine , Jinan, China .
Zi-Jiang
ZJ
Chen
D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011401:Promoter Regions, Genetic; D058949:Uromodulin / Q000235:genetics*
C548612:UMOD protein, human; D058949:Uromodulin