Aneuploidy and proteotoxic stress in cancer.
Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between two recurring features of cancer cells: aneuploidy and proteotoxic stress. Further, our findings implicate HSF1 as a key factor in mitigating the effects of aneuploidy.
Group Maintenance of Genome Stability; Max Planck Institute of Biochemistry ; Martinsried, Germany.
Neysan
N
Donnelly
Group Maintenance of Genome Stability; Max Planck Institute of Biochemistry; Martinsried, Germany; Center for Integrated Protein Science; Ludwig-Maximilian-University; Munich, Germany.
Zuzana
Z
Storchová
HSF1; HSP90; aneuploidy; cancer; proteotoxic stress