Use of metformin earlier in pregnancy predicts supplemental insulin therapy in women with gestational diabetes.
The use of metformin in gestational diabetes is safe and effective, yet some women require additional insulin therapy to achieve glycaemic targets. We found a significant association between earlier gestational age at initiation of metformin therapy and the necessity for supplemental insulin in women treated with metformin during pregnancy.
Department of Diabetes, Endocrinology & Metabolism, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia; Northern Clinical School, University of Sydney, Sydney, Australia; Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia. Electronic address: rachel.mcgrath@sydney.edu.au.
Rachel T
RT
McGrath
Department of Diabetes, Endocrinology & Metabolism, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia; Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia.
Sarah J
SJ
Glastras
Department of Diabetes, Endocrinology & Metabolism, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia; Northern Clinical School, University of Sydney, Sydney, Australia; Charles Perkins Centre, University of Sydney, Australia.
Samantha
S
Hocking
Department of Diabetes, Endocrinology & Metabolism, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia; Northern Clinical School, University of Sydney, Sydney, Australia.
Gregory R
GR
Fulcher
D000328:Adult; D001786:Blood Glucose; D016640:Diabetes, Gestational / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005865:Gestational Age; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D008687:Metformin / Q000627:therapeutic use*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D008687:Metformin; C517652:hemoglobin A1c protein, human
Gestational diabetes; Glycaemic control; Insulin; Metformin; Perinatal outcomes