Review of Mouse Models Applied to the Study of Asthma.
The diversity of asthma phenotypes increases its complexity. Animal models represent a useful tool to elucidate the pathophysiological mechanisms involved in both allergic and nonallergic asthma, as well as to identify potential targets for the development of new treatments. Among all available animal models, mice offer significant advantages for the study of asthma. In this chapter, the applications of mouse models to the study of asthma will be reviewed.
Department of Clinical Biochemistry, University Hospital of Salamanca, Paseo de San Vicente 58, Salamanca, 37007, Spain. f.marg@hotmail.es.|Salamanca Institute for Biomedical Research (IBSAL), Salamanca, Spain. f.marg@hotmail.es.
Fernando
F
Marqués-García
Department of Clinical Biochemistry, University Hospital of Salamanca, Paseo de San Vicente 58, Salamanca, 37007, Spain.|Salamanca Institute for Biomedical Research (IBSAL), Salamanca, Spain.
Elena
E
Marcos-Vadillo
D000281:Administration, Intranasal; D000485:Allergens / Q000009:adverse effects; D000818:Animals; D001249:Asthma / Q000139:chemically induced* / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D007274:Injections, Intraperitoneal; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype
D000485:Allergens
Animal models; Asthma; Challenge; Mouse; Sensitization