The CYBA Gene (⁎)49A>G Polymorphism (rs7195830) Is Associated with Hypertension in Patients with Coronary Artery Disease.
Purpose. Single nucleotide polymorphisms of the CYBA gene may modify the risk of coronary artery disease (CAD). The aim of the present study was to investigate whether the (⁎)49A>G (rs7195830) polymorphism is associated with CAD. Materials and Methods. CYBA gene (⁎)49A>G polymorphism was determined in 481 subjects: 242 patients with premature CAD and 239 age and sex matched controls using the fluorescently labeled allele-specific oligonucleotides method. Results. The frequency of the (⁎)49G allele carrier state was significantly higher in patients than in controls (84.8% versus 76.6%, resp., P = 0.020), as well as the frequency of the (⁎)49G allele (62.2% versus 54.0%, P = 0.009). Both factors were associated with CAD in the analyzed population (OR = 1.70, 95% CI: 1.04-2.76 for GG+AG versus AA and OR = 1.40, 95% CI: 1.08-1.83 for (⁎)49G versus  (⁎)49A). Carrier state of the (⁎)49G allele was a stronger and independent risk factor for CAD among women (OR = 4.35, 95% CI: 1.50-13.20, P = 0.002), as well as the (⁎)49G allele (OR = 2.25, 95% CI: 1.34-3.77, P = 0.001). The (⁎)49G allele carrier state was also associated with left ventricular hypertrophy in patients with coronary artery disease (P = 0.015). Conclusion. The CYBA gene (⁎)49A>G polymorphism modifies the risk of coronary artery disease.
School of Health Sciences in Katowice, Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland.
Tomasz
T
Nowak
School of Health Sciences in Katowice, Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland.
Paweł
P
Niemiec
School of Medicine and Division of Dentistry in Zabrze, Department of Internal Medicine, Diabetes and Nephrology, Medical University of Silesia, 3 Maja Street 13-18, 41-800 Zabrze, Poland.
Sylwia
S
Górczyńska-Kosiorz
School of Health Sciences in Katowice, Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland.
Anna
A
Balcerzyk
School of Health Sciences in Katowice, Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland.
Tomasz
T
Iwanicki
1st Department of Cardiac Surgery/2nd Department of Cardiology, American Heart of Poland, S. A. Armii Krajowej Street 101, 43-316 Bielsko-Biala, Poland.
Jolanta
J
Krauze
School of Medicine and Division of Dentistry in Zabrze, Department of Internal Medicine, Diabetes and Nephrology, Medical University of Silesia, 3 Maja Street 13-18, 41-800 Zabrze, Poland.
Wladyslaw
W
Grzeszczak
Regional Centre of Blood Donation and Blood Treatment in Raciborz, Sienkiewicza Street 3, 47-400 Raciborz, Poland.
Anna
A
Ochalska-Tyka
School of Health Sciences in Katowice, Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland.
Joanna
J
Iwanicka
School of Health Sciences in Katowice, Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland.
Iwona
I
Zak
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000150:complications* / Q000235:genetics*; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000235:genetics*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D019255:NADPH Oxidases / Q000235:genetics*; D016017:Odds Ratio; D009841:Oligonucleotides / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D017422:Sequence Analysis, DNA
D008055:Lipids; D009841:Oligonucleotides; D019255:NADPH Oxidases; C086986:CYBA protein, human