Engineering and manufacturing of pharmaceutical co-crystals: a review of solvent-free manufacturing technologies.
Design and synthesis of pharmaceutical cocrystals have received great interest in recent years. Cocrystallization of drug substances offers a tremendous opportunity for the development of new drug products with superior physical and pharmacological properties such as solubility, stability, hydroscopicity, dissolution rates and bioavailability. It is now possible to engineer and develop cocrystals via 'green chemistry' and environmentally friendly approaches such as solid-state synthesis in the absence of organic solvents. In addition, significant efforts have been directed towards computational screening, cocrystal manufacturing in a continuous manner and real-time monitoring for quality purposes by using various analytical tools. Pharmaceutical cocrystals are not fully exploited yet and there is a lot of ground to cover before they can be successfully utilized as medical products.
Faculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK. d.douroumis@gre.ac.uk.
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Ross
Strathclyde Institute of Pharmacy and Biomedical Science (SIPBS)s, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. dimitrios.lamprou@strath.ac.uk and EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation (CMAC), University of Strathclyde, Technology and Innovation Centre, 99 George Street, Glasgow, G1 1 RD, UK.
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Lamprou
Faculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK. d.douroumis@gre.ac.uk.
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D003460:Crystallization; D008420:Manufactured Materials; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry*; D012995:Solubility
D004364:Pharmaceutical Preparations