Activated Acinus boosts basal autophagy.
Acinus (Acn) is a nuclear protein that participates in the regulation of autophagy. Loss of Acn function prevents autophagy in starving cells. Conversely, Acn activation induces basal autophagy. This enhances the quality control functions of autophagy such as the removal of misfolded proteins, thereby reducing neurodegeneration and prolonging lifespan. Acn activity is enhanced by Akt1-mediated phosphorylation, which counteracts the cleavage of Acn by a caspase-3 homolog.
Department of Neuroscience; UT Southwestern Medical Center ; Dallas, TX, USA.
Nilay
N
Nandi
Department of Neuroscience; UT Southwestern Medical Center ; Dallas, TX, USA.
Lauren K
LK
Tyra
Department of Neuroscience; UT Southwestern Medical Center; Dallas, TX, USA; Department of Cell Biology; UT Southwestern Medical Center; Dallas, TX, USA.
Helmut
H
Krämer