Heparanase tailors syndecan for exosome production.
Exosomes are secreted vesicles involved in signaling processes. The biogenesis of a class of these vesicles depends on syntenin and syndecans. Heparanase acts as a regulator of the syndecan-syntenin-exosome biogenesis pathway. The upregulation of syntenin and heparanase in cancers may support the suspected roles of exosomes in tumor biology.
Laboratory for Glycobiology and Developmental Genetics, Department of Human Genetics, KU Leuven , Leuven, Belgium.
Guido
G
David
Laboratory for Signal Integration in Cell Fate Decision, Department of Human Genetics, KU Leuven, Leuven, Belgium; Centre de Recherche en Cancérologie de Marseille (CRCM), Aix-Marseille Université, Marseille, F-13284, France, Inserm, U1068, Institut Paoli-Calmettes, CNRS, UMR7258, Marseille, France.
Pascale
P
Zimmermann
ALIX; ESCRT; PDZ domains; exosomal cargo; exosome; heparan sulfate; heparanase; syndecan; syntenin; tumor progression