[Molecular Mechanism of Glycoprotein-induced Cell-Cell Fusion of Herpesviruses].
Herpesviridae is a large family comprising linear, double-stranded DNA viruses. Herpesviridae contains three subfamilies: α-, β- and γ-herpesviruses. The glycoproteins gB, gH and gL of each subfamily form the "core fusion function" in cell-cell fusion. Other herpesviruses also need additional glycoproteins to promote fusion, such as gD of the Herpes simplex virus, gp42 of the Epstein-Barr virus, and gO or UL128-131 of the Human cytomegalovirus. In contrast, glycoproteins gM or gM/gN of herpesvirus inhibit fusion. We describe the molecular mechanisms of glycoprotein-induced fusion and entry of herpesviruses. It will be helpful to further study the pathogenic mechanism of herpesvirus.
Daishen
D
Feng
Renyong
R
Jia
D000818:Animals; D002459:Cell Fusion; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D006564:Herpesviridae / Q000235:genetics / Q000378:metabolism*; D006566:Herpesviridae Infections / Q000503:physiopathology / Q000821:virology*; D006801:Humans; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
D006023:Glycoproteins; D014764:Viral Proteins