Do changes in the c-MYC coding sequence contribute to tumorigenesis?
The role of changes in the c-MYC coding sequence in cancer is controversial. Overexpression of wild-type protein is sufficient to drive tumorigenesis, yet point mutations in c-MYC are common in Burkitt's lymphoma. Our discovery that disparate tumor-associated mutations in c-MYC have similar protumorigenic effects suggests that these mutations contribute directly to malignancy.
Department of Cell and Developmental Biology; Vanderbilt University School of Medicine; Nashville, TN USA; Present address: Department of Medical Oncology; Dana-Farber Cancer Institute and Brigham and Women's Hospital; Boston, MA USA.
Abhishek A
AA
Chakraborty
Department of Cell and Developmental Biology; Vanderbilt University School of Medicine ; Nashville, TN USA.
William P
WP
Tansey
MYC; cancer; lymphomagenesis; mutation; proteolysis