Interleukin-17A and -17F Gene Polymorphisms in Chinese Population with Chronic Immune Thrombocytopenia.
BACKGROUND
A case-control study was conducted to evaluate the influence of interleukin (IL)-17A and -17F gene polymorphisms on the risk of primary chronic immune thrombocytopenia (ITP).


METHODS
The study included 146 Chinese chronic ITP patients and 137 healthy controls. IL-17A G197A and IL-17F A7488G polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).


RESULTS
No significant difference in frequencies of IL-17A G197A genotypes and alleles was found between ITP patients and healthy controls, whereas frequencies of IL-17F A7488G allele A were significantly higher in ITP patients than that in healthy controls (31.85% vs. 18.98%; P<0.01). More specifically, patients with ITP had significantly higher frequencies of the IL-17F A7488G AA and AG genotypes compared with healthy controls (AA: 17.12% vs. 9.49%, P=0.02; AG: 29.46% vs. 18.98%, P=0.02). Logistic regression analysis revealed that AA and AG genotypes of IL-17F A7488G were associated with increased risk of ITP (AA: odds ratio (OR)=2.33, 95% CI 1.11-4.89; AG: OR=2.03, 95% CI 1.14-3.61).


CONCLUSIONS
Our results suggest that SNPs in IL-17F A7488G but not IL-17A are associated with the development of chronic ITP in China.
Department of Hematology, Qilu Hospital, Shandong University, Jinan, P. R. China. Taian City Central Hospital, Taian, P. R. China.
Shuang
S
Liu
Department of Hematology, Qilu Hospital, Shandong University, Jinan, P. R. China. Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, P. R. China.
You-Zhen
YZ
Xiong
Department of Gastroenterology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, P. R. China.
Tao
T
Li
Department of paediatrics, The people's Hospital of Shouguang, 1233 Jiankang Street, shouguang, P. R. China.
Yuan
Y
Li
Department of Gastroenterology, The people's Hospital of Shouguang, 1233 Jiankang Street, shouguang, P. R. China.
Sheng-Qing
SQ
Gu
Department of Hematology, Qilu Hospital, Shandong University, Jinan, P. R. China.
Yan-Ming
YM
Wang
Department of Psychiatry, Mental Health center of Shandong Province, West Wenhua Road, Jinan, P. R. China.
Kai-Hong
KH
Zhang
Department of Hematology, Qilu Hospital, Shandong University, Jinan, P. R. China.
Ming
M
Hou
Department of Hematology, Qilu Hospital, Shandong University, Jinan, P. R. China. Liuxingrant@163.com.
Xin-Guang
XG
Liu
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000235:genetics*; D012307:Risk Factors
C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17
IL-17A; IL-17F; polymorphism; primary immune thrombocytopenia