The emerging role of deubiquitination in nucleotide excision repair.
Nucleotide excision repair (NER) protects genome stability by eliminating DNA helix distorting lesions, such as those induced by UV radiation. The addition and removal of ubiquitin, namely, ubiquitination and deubiquitination, have recently been demonstrated as general mechanisms to regulate protein functions. Accumulating evidence shows that several NER factors are subjected to extensive regulation by ubiquitination and deubiquitination. Thus, the balance between E3 ligases and deubiquitinating enzyme activities can dynamically alter the ubiquitin landscape at DNA damage sites, thereby regulating NER efficiency. Current knowledge about XPC ubiquitination by different ubiquitin E3 ligases highlights the importance of ubiquitin linkage types in regulating XPC binding and release from damaged DNA. Here, we discuss the emerging roles of deubiquitinating enzymes and their ubiquitin linkage specificities in NER.
Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, United States.
Ling
L
Zhang
Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, United States. Electronic address: fgong@med.miami.edu.
Feng
F
Gong
D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004249:DNA Damage / Q000528:radiation effects; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015894:Genome, Human; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D025801:Ubiquitin / Q000235:genetics / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase / Q000235:genetics / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D054875:Ubiquitination; D014466:Ultraviolet Rays
D002843:Chromatin; D004268:DNA-Binding Proteins; D007527:Isoenzymes; D009687:Nuclear Proteins; D025801:Ubiquitin; C086984:XPC protein, human; D004247:DNA; C486067:RNF111 protein, human; D044767:Ubiquitin-Protein Ligases; D043222:Ubiquitin Thiolesterase
DUBs; Deubiquitination; E3 ubiquitin ligase; GG-NER; Segregase; TC-NER; Ubiquitin linkage specificity; Ubiquitination