The CDC20-APC/SOX2 signaling axis: An achilles' heel for glioblastoma.
Glioblastoma stem-like cells (GSCs) play a critical role in glioblastoma progression and recurrence. We discuss recent results on the role of the mitotic ubiquitin ligase cell division cycle 20-anaphase-promoting complex (CDC20-APC) in the governance of cardinal GSC functions through a mechanism involving the transcription factor sex-determining region Y-box 2 (SOX2). These findings expand the non-mitotic roles of CDC20-APC with implications for stem cell biology.
Department of Neurological Surgery, Washington University School of Medicine , St. Louis, Missouri, USA.
Amit D
AD
Gujar
Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Hiroko
H
Yano
Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri, USA; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, USA; Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri, USA.
Albert H
AH
Kim
CDC20; CDC20–anaphase-promoting complex; Cancer stem cells; SOX2; glioblastoma; glioblastoma stem-like cells; in vivo tumorigenicity; invasion; self-renewal; tumor-initiating cells