Radiotherapy combined with an engineered Salmonella typhimurium inhibits tumor growth in a mouse model of colon cancer.
The engineered Salmonella typhimurium ΔppGpp (S.t ΔppGpp) has been studied in terms of its ability to carry imaging probes (bacterial luciferase, Lux) for tumor imaging or carry therapeutic molecules (Cytolysin A) to kill cancer cells. To establish a novel cancer therapy, bacterial therapy was combined with radiotherapy using the attenuated strain S.t ΔppGpp/pBAD-ClyA. Radiotherapy (21Gy) contributed to S. typhimurium colonization in a colon tumor (CT26) model of BALB/c mice. The combination of bacterial therapy and radiotherapy treatments reduced tumor growth compared with only bacterial therapy.
Department of Veterinary Medicine, Hainan University, 58 Renmin Road, Haikou, Hainan 570228, P.R. China.
Xiande
X
Liu
Shengnan
S
Jiang
Linghua
L
Piao
Feng
F
Yuan
D000818:Animals; D063646:Carcinogenesis / Q000528:radiation effects; D003110:Colonic Neoplasms / Q000382:microbiology / Q000532:radiotherapy / Q000628:therapy*; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D008163:Luminescent Measurements; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D030781:Organisms, Genetically Modified / Q000235:genetics; D052899:Pore Forming Cytotoxic Proteins / Q000627:therapeutic use*; D012486:Salmonella typhimurium / Q000235:genetics
D052899:Pore Forming Cytotoxic Proteins; C483886:perforin, mouse