Haploidentical Stem Cell Transplantation in Adult Haematological Malignancies.
Haematopoietic stem cell transplantation is a well-established treatment option for both hematological malignancies and nonmalignant conditions such as aplastic anemia and haemoglobinopathies. For those patients lacking a suitable matched sibling or matched unrelated donor, haploidentical donors are an alternative expedient donor pool. Historically, haploidentical transplantation led to high rates of graft rejection and GVHD. Strategies to circumvent these issues include T cell depletion and management of complications thereof or T replete transplants with GVHD prophylaxis. This review is an overview of these strategies and contemporaneous outcomes for hematological malignancies in adult haploidentical stem cell transplant recipients.
Department of Haematology, Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK; Kings College London, Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK.
Kevon
K
Parmesar
Department of Haematology, Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK; Department of Haematology, Guys and St. Thomas' NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.
Kavita
K
Raj