BRCA1: a movement toward cancer prevention.
Breast cancer susceptibility gene 1 (BRCA1) was first identified in 1994 and has since been shown to encode a tumor suppressor protein that maintains genetic stability through DNA damage response pathways. Carriers of mutations in BRCA1 are predisposed to breast and ovarian cancer; however, their cancers lack the targets for existing anticancer drugs. We describe a novel chemoprevention approach that uses DNA repair-activating agents to enhance the repair of oxidative DNA damage and, in turn, prevent tumorigenesis in the presence of mutant BRCA1.
Stanford University School of Medicine; Department of Medicine-Oncology ; Stanford, CA USA.
Elizabeth
E
Alli
Stanford University School of Medicine; Department of Medicine-Oncology ; Stanford, CA USA.
James M
JM
Ford
BRCA1; base-excision DNA repair; breast cancer; chemoprevention; oxidative DNA damage