Serotype Distribution and Antimicrobial Resistance of Streptococcus pneumoniae Isolates Causing Invasive and Noninvasive Pneumococcal Diseases in Korea from 2008 to 2014.
Introduction. Streptococcus pneumoniae is an important pathogen with high morbidity and mortality rates. The aim of this study was to evaluate the distribution of common serotypes and antimicrobial susceptibility of S. pneumoniae in Korea. Methods. A total of 378 pneumococcal isolates were collected from 2008 through 2014. We analyzed the serotype and antimicrobial susceptibility for both invasive and noninvasive isolates. Results. Over the 7 years, 3 (13.5%), 35 (10.8%), 19A (9.0%), 19F (6.6%), 6A (6.1%), and 34 (5.6%) were common serotypes/serogroups. The vaccine coverage rates of PCV7, PCV10, PCV13, and PPSV23 were 21.4%, 23.3%, 51.9%, and 62.4% in all periods. The proportions of serotypes 19A and 19F decreased and nonvaccine serotypes increased between 2008 and 2010 and 2011 and 2014. Of 378 S. pneumoniae isolates, 131 (34.7%) were multidrug resistant (MDR) and serotypes 19A and 19F were predominant. The resistance rate to levofloxacin was significantly increased (7.2%). Conclusion. We found changes of pneumococcal serotype and antimicrobial susceptibility during the 7 years after introduction of the first pneumococcal vaccine. It is important to continuously monitor pneumococcal serotypes and their susceptibilities.
Department of Laboratory Medicine, Inje University College of Medicine, Busan 47392, Republic of Korea; Paik Institute for Clinical Research, Inje University College of Medicine, Busan 47392, Republic of Korea.
Si Hyun
0000-0003-0713-7985
SH
Kim
Department of Dental Hygiene, College of Health and Welfare, Silla University, Busan 46958, Republic of Korea.
Il Kwon
IK
Bae
Department of Laboratory Medicine, Inje University College of Medicine, Busan 47392, Republic of Korea; Paik Institute for Clinical Research, Inje University College of Medicine, Busan 47392, Republic of Korea.
Dongchul
D
Park
Department of Laboratory Medicine, Inje University College of Medicine, Busan 47392, Republic of Korea; Paik Institute for Clinical Research, Inje University College of Medicine, Busan 47392, Republic of Korea.
Kyungmin
0000-0001-5558-4304
K
Lee
Department of Laboratory Medicine, Inje University College of Medicine, Busan 47392, Republic of Korea; Paik Institute for Clinical Research, Inje University College of Medicine, Busan 47392, Republic of Korea.
Na Young
NY
Kim
Department of Laboratory Medicine, Inje University College of Medicine, Busan 47392, Republic of Korea.
Sae Am
SA
Song
Department of Laboratory Medicine, Inje University College of Medicine, Busan 47392, Republic of Korea.
Hye Ran
0000-0002-6097-2085
HR
Kim
Department of Pediatrics, Inje University College of Medicine, Busan 47392, Republic of Korea.
Ga Won
0000-0002-8206-9727
GW
Jeon
Preventive Medicine, Inje University College of Medicine, Busan 47392, Republic of Korea.
Sang-Hwa
SH
Urm
Department of Laboratory Medicine, Inje University College of Medicine, Busan 47392, Republic of Korea; Paik Institute for Clinical Research, Inje University College of Medicine, Busan 47392, Republic of Korea.
Jeong Hwan
JH
Shin
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D015995:Prevalence; D056910:Republic of Korea; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification*; D055815:Young Adult
D000890:Anti-Infective Agents