Pancreatic perfusion and subsequent response to glucose in healthy individuals and patients with type 1 diabetes.
The aim of this study was to investigate pancreatic perfusion and its response to a glucose load in patients with type 1 diabetes mellitus compared with non-diabetic ('healthy') individuals.



Eight individuals with longstanding type 1 diabetes and ten sex-, age- and BMI-matched healthy controls underwent dynamic positron emission tomography scanning with (15)O-labelled water before and after intravenous administration of glucose. Perfusion in the pancreas was measured. Portal and arterial hepatic perfusion were recorded as references.



Under fasting conditions, total pancreatic perfusion was on average 23% lower in the individuals with diabetes compared with healthy individuals. Glucose increased total pancreatic and portal hepatic blood perfusion in healthy individuals by 48% and 38%, respectively. In individuals with diabetes there was no significant increase in either total pancreatic or portal hepatic perfusion.



Individuals with type 1 diabetes have reduced basal pancreatic perfusion and a severely impaired pancreatic and splanchnic perfusion response to intravenous glucose stimulation.
Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.
Lina
L
Carlbom
Department of Medical Cell Biology, Uppsala University, Husargatan 3, SE-751 23, Uppsala, Sweden.|Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Daniel
D
Espes
Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.
Mark
M
Lubberink
Department of Medicinal Chemistry, Preclinical PET Platform, Uppsala University, Uppsala, Sweden.
Olof
O
Eriksson
Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.
Lars
L
Johansson
Department of Medical Cell Biology, Uppsala University, Husargatan 3, SE-751 23, Uppsala, Sweden.
Leif
L
Jansson
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Olle
O
Korsgren
Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.
Håkan
H
Ahlström
Department of Medical Cell Biology, Uppsala University, Husargatan 3, SE-751 23, Uppsala, Sweden. per-ola.carlsson@mcb.uu.se.|Department of Medical Sciences, Uppsala University, Uppsala, Sweden. per-ola.carlsson@mcb.uu.se.
Per-Ola
PO
Carlsson
D000293:Adolescent; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism*; D010477:Perfusion; D049268:Positron-Emission Tomography; D055815:Young Adult
D007328:Insulin; D005947:Glucose
Blood flow; Glucose; Pancreas; Pancreatic islets; Perfusion; Type 1 diabetes