Modeling the Kinetics of Open Self-Assembly.
In this work, we explore theoretically the kinetics of molecular self-assembly in the presence of constant monomer flux as an input, and a maximal size. The proposed model is supposed to reproduce the dynamics of viral self-assembly for enveloped virus. It turns out that the kinetics of open self-assembly is rather quantitatively different from the kinetics of similar closed assembly. In particular, our results show that the convergence toward the stationary state is reached through assembly waves. Interestingly, we show that the production of complete clusters is much more efficient in the presence of a constant input flux, rather than providing all monomers at the beginning of the self-assembly.
Univ Lyon, Ens de Lyon, Université Claude Bernard, CNRS, Laboratoire de Physique, F-69342 Lyon, France.
Timothée
T
Verdier
Laboratoire de Physique Statistique, Ecole Normale Supérieure, PSL Research University, Université Paris Diderot Sorbonne Paris-Cité, Sorbonne Universités UPMC Univ Paris 06, CNRS, 24 rue Lhomond, 75005 Paris, France.
Lionel
L
Foret
Univ Lyon, Ens de Lyon, Université Claude Bernard, CNRS, Laboratoire de Physique, F-69342 Lyon, France.
Martin
M
Castelnovo
D004058:Diffusion; D007700:Kinetics; D008958:Models, Molecular; D055503:Protein Multimerization; D019065:Virus Assembly