The Uranyl Cation as a Visible-Light Photocatalyst for C(sp(3) )-H Fluorination.
The fluorination of unactivated C(sp(3) )-H bonds remains a desirable and challenging transformation for pharmaceutical, agricultural, and materials scientists. Previous methods for this transformation have used bench-stable fluorine atom sources; however, many still rely on the use of UV-active photocatalysts for the requisite high-energy hydrogen atom abstraction event. Uranyl nitrate hexahydrate is described as a convenient, hydrogen atom abstraction catalyst that can mediate fluorinations of certain alkanes upon activation with visible light.
Department of Chemistry, Princeton University, Princeton, NJ, USA.
Julian G
JG
West
Department of Chemistry, Princeton University, Princeton, NJ, USA.
T Aaron
TA
Bedell
Department of Chemistry, Princeton University, Princeton, NJ, USA. ejs@princeton.edu.
Erik J
EJ
Sorensen
C−H activation; fluorination; hydrogen atom transfer; photocatalysis; uranium