Effect of constitutive inactivation of the myostatin gene on the gain in muscle strength during postnatal growth in two murine models.
The effect of constitutive inactivation of the gene encoding myostatin on the gain in muscle performance during postnatal growth has not been well characterized.



We analyzed 2 murine myostatin knockout (KO) models, (i) the Lee model (KOLee) and (ii) the Grobet model (KOGrobet), and measured the contraction of tibialis anterior muscle in situ.



Absolute maximal isometric force was increased in 6-month-old KOLeeand KOGrobetmice, as compared to wild-type mice. Similarly, absolute maximal power was increased in 6-month-old KOLeemice. In contrast, specific maximal force (relative maximal force per unit of muscle mass was decreased in all 6-month-old male and female KO mice, except in 6-month-old female KOGrobetmice, whereas specific maximal power was reduced only in male KOLeemice.



Genetic inactivation of myostatin increases maximal force and power, but in return it reduces muscle quality, particularly in male mice. Muscle Nerve 55: 254-261, 2017.
Université de Versailles Saint-Quentin, Unité de formation et de recherche des sciences de la santé des sciences, Montigny-le-Bretonneux, France.
Amalia
A
Stantzou
Université de Strasbourg, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
Vanessa
V
Ueberschlag-Pitiot
Université Paris Descartes, Institut de Recherche bio-Médicale et d'Epidémiologie du Sport, Sorbonne Paris Cité, Paris, France.
Remi
R
Thomasson
Sorbonne Universités CNRS, Centre de Recherche en Myologie, Paris, France.
Denis
D
Furling
INRA, Université Montpellier, Dynamique Musculaire et Métabolisme, Montpellier, France.
Anne
A
Bonnieu
Université de Versailles Saint-Quentin, Unité de formation et de recherche des sciences de la santé des sciences, Montigny-le-Bretonneux, France.
Helge
H
Amthor
Sorbonne Universités CNRS, Centre de Recherche en Myologie, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Arnaud
A
Ferry
D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009119:Muscle Contraction / Q000235:genetics*; D053580:Muscle Strength / Q000235:genetics*; D018482:Muscle, Skeletal / Q000502:physiology*; D009135:Muscular Diseases / Q000235:genetics / Q000473:pathology*; D055435:Myostatin / Q000172:deficiency* / Q000235:genetics; D012737:Sex Factors
C525912:Mstn protein, mouse; D055435:Myostatin
castration; force; knockout; myostatin; orchidectomy; postnatal growth; power; skeletal muscle