Often Asked but Rarely Answered: Can Asians Meet DSM-5/ICD-10 Autism Spectrum Disorder Criteria?
To evaluate whether Asian (Korean children) populations can be validly diagnosed with autism spectrum disorder (ASD) using Western-based diagnostic instruments and criteria based on Diagnostic and Statistical Manual on Mental Disorders, 5th edition (DSM-5).



Participants included an epidemiologically ascertained 7-14-year-old (N = 292) South Korean cohort from a larger prevalence study (N = 55,266). Main outcomes were based on Western-based diagnostic methods for Korean children using gold standard instruments, Autism Diagnostic Interview-Revised, and Autism Diagnostic Observation Schedule. Factor analysis and ANOVAs were performed to examine factor structure of autism symptoms and identify phenotypic differences between Korean children with ASD and non-ASD diagnoses.



Using Western-based diagnostic methods, Korean children with ASD were successfully identified with moderate-to-high diagnostic validity (sensitivities/specificities ranging 64%-93%), strong internal consistency, and convergent/concurrent validity. The patterns of autism phenotypes in a Korean population were similar to those observed in a Western population with two symptom domains (social communication and restricted and repetitive behavior factors). Statistically significant differences in the use of socially acceptable communicative behaviors (e.g., direct gaze, range of facial expressions) emerged between ASD versus non-ASD cases (mostly p < 0.001), ensuring that these can be a similarly valid part of the ASD phenotype in both Asian and Western populations.



Despite myths, biases, and stereotypes about Asian social behavior, Asians (at least Korean children) typically use elements of reciprocal social interactions similar to those in the West. Therefore, standardized diagnostic methods widely used for ASD in Western culture can be validly used as part of the assessment process and research with Koreans and, possibly, other Asians.
1 Department of Psychiatry, Weill Cornell Medicine , White Plains, New York.
So Hyun
SH
Kim
2 Department of Psychiatry, University of California San Francisco , San Francisco, California.|3 Department of Psychiatry, Yonsei University College of Medicine , Seoul, South Korea .
Young Shin
YS
Kim
4 The Korea Institute for Children's Social Development , Seoul, South Korea .
Yun-Joo
YJ
Koh
4 The Korea Institute for Children's Social Development , Seoul, South Korea .
Eun-Chung
EC
Lim
5 Psychiatry and Behavioral Sciences, Center for Integrative Brain Research, Seattle Children's Research Institute, University of Washington , Seattle, Washington.
Soo-Jeong
SJ
Kim
2 Department of Psychiatry, University of California San Francisco , San Francisco, California.|3 Department of Psychiatry, Yonsei University College of Medicine , Seoul, South Korea .
Bennett L
BL
Leventhal
D000293:Adolescent; D044466:Asian People; D000067877:Autism Spectrum Disorder / Q000175:diagnosis*; D002648:Child; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D010641:Phenotype; D056910:Republic of Korea; D012680:Sensitivity and Specificity; D012919:Social Behavior
autism spectrum disorder; cross-cultural application; diagnostic assessment