Chemical constituents from the rhizome of Polygonum paleaceum and their antifungal activity.
A new compounds neopaleaceolactoside (1), along with nine known compounds phyllocoumarin (2), quercetin (3), quercitrin (4), quercetin-3-methyl ether (5), vincetoxicoside B (6), isoquercitrin (7), kaempferol (8), (-)-epicatechin (9), and chlorogenic acid (10), was isolated from Polygonum paleaceum Wall. Their chemical structures were established based on one-dimensional and two-dimensional nuclear magnetic resonance techniques, mass spectrometry and by comparison with spectroscopic data reported. Some selected compounds were screened for their antifungal activity. Quercetin (3), vincetoxicoside B (6), kaempferol (8), and (-)-epicatechin (9) showed synergistic antifungal activities with the FICI values <0.5. A preliminary structure-activity relationship could be observed that free 3-OH in the structure of flavonoids was important for synergistic antifungal activity.
a School of Pharmacy , Second Military Medical University , Shanghai 200433 , China.
Yi-Xi
YX
Yang
b School of Medicine , Tongji University , Shanghai 200092 , China.
Mao-Mao
MM
An
a School of Pharmacy , Second Military Medical University , Shanghai 200433 , China.
Yong-Sheng
YS
Jin
a School of Pharmacy , Second Military Medical University , Shanghai 200433 , China.
Hai-Sheng
HS
Chen
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D044949:Kaempferols / Q000494:pharmacology; D015394:Molecular Structure; D028502:Polygonum / Q000737:chemistry*; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D044949:Kaempferols; C000614025:neopaleaceolactoside; C459210:quercetin 3-O-methyl ether; C016527:isoquercitrin; C012526:quercitrin; C006552:kaempferol; D011794:Quercetin
Polygonaceae; Polygonum paleaceum; antifungal activity; flavonoids; synergist