Opposing Effects of Antidiabetic Interventions on Malignant Growth and Metastasis.
Type 2 diabetes is associated with increased risk of malignancies, whereas antidiabetic interventions like physical exercise or metformin reduce cancer incidence. A recent publication shows that one diabetes treatment approach, namely incretin-related DPP4 inhibitors, increases metastatic capacity by activating the antioxidant transcription factor NRF2 to decrease reactive oxygen species (ROS) levels.
Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
Matthias H
MH
Tschöp
German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Division of Endocrinology, University Hospital Leipzig, 04103 Leipzig, Germany.
Michael
M
Stumvoll
Department of Health Sciences and Technology, Swiss Federal Institute of Technology Zurich (ETHZ), 8092 Zurich, Switzerland. Electronic address: michael-ristow@ethz.ch.
Michael
M
Ristow
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D017382:Reactive Oxygen Species / Q000378:metabolism
D007004:Hypoglycemic Agents; D017382:Reactive Oxygen Species