Junk DNA Used in Cerebral Cortical Evolution.
In this issue of Neuron, Rani et al. (2016) address important questions about the mechanisms of cerebral cortical evolution. They describe how a primate-specific long non-coding RNA titrates the levels of a microRNA that regulates an ancient signaling pathway controlling neuronal numbers.
Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.
Thomas
T
Pratt
Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK. Electronic address: david.price@ed.ac.uk.
David J
DJ
Price
D000818:Animals; D006801:Humans; D002540:Cerebral Cortex; D021901:DNA, Intergenic; D035683:MicroRNAs / Q000235:genetics; D009474:Neurons; D062085:RNA, Long Noncoding
D021901:DNA, Intergenic; D035683:MicroRNAs; D062085:RNA, Long Noncoding
Notch signaling; cerebral cortical development; competing endogenous RNA; long non-coding RNA; microRNA