Serum Uric Acid Levels were Dynamically Coupled with Hemoglobin A1c in the Development of Type 2 Diabetes.
The aim of the study was to decipher the relationship between serum uric acid (SUA) and glycated hemoglobin A1c (HbA1c) or fasting plasma glucose (FPG) in both type 2 diabetes mellitus (T2DM) patients and normal subjects. A total of 2,250 unrelated T2DM patients and 4,420 Han Chinese subjects from a physical examination population were recruited for this study. In T2DM patients SUA levels were negatively correlated with HbA1c (rs = -0.109, P = 0.000) and 2 h plasma glucose levels (rs = -0.178, P = 0.000). In the physical examination population, SUA levels were inversely correlated with HbA1c (rs = -0.175, P = 0.000) and FPG (rs = -0.131, P = 0.009) in T2DM patients but positively correlated with HbA1c (rs = 0.040, P = 0.012) and FPG (rs = 0.084, P = 0.000) in normal-glucose subjects. Multivariate analyses showed that HbA1c was significantly negatively associated with HUA both in T2DM patients (OR = 0.872, 95% CI: 0.790~0.963) and in the physical examination T2DM patients (OR = 0.722, 95% CI: 0.539~0.968). Genetic association studies in T2DM patients showed that alleles of two glucose-uric acid transporter genes, ABCG2 and SLC2A9 were significantly associated with SUA levels (P < 0.05). SUA level is inversely correlated with HbA1c in T2DM patients but positively correlated with HbA1c in normal-glucose subjects. The reverse transporting of uric acid and glucose in renal tubules might be accounted for these associations.
Center of Basic Medical Sciences, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, P.R. China.
Fengjiang
F
Wei
Metabolic Diseases Hospital, Tianjin Medical University, Tianjin, 300070, P.R. China.
Baocheng
B
Chang
Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, P.R. China.
Xilin
X
Yang
School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, P.R. China.
Yaogang
Y
Wang
Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, P.R. China.
Liming
L
Chen
Center of Basic Medical Sciences, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, P.R. China.
Wei-Dong
WD
Li
D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2 / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000209:etiology* / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009363:Neoplasm Proteins / Q000235:genetics; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D001786:Blood Glucose; D051246:Glucose Transport Proteins, Facilitative; D006442:Glycated Hemoglobin; D009363:Neoplasm Proteins; D014527:Uric Acid; C116614:ABCG2 protein, human; C411811:SLC2A9 protein, human; C517652:hemoglobin A1c protein, human