Antioxidant activity of levan coated cerium oxide nanoparticles.
Levan coated cerium oxide nanoparticles (LCNPs) with the enhanced antioxidant activity were successfully synthesized and characterized. Levan and their derivatives are attractive for biomedical applications attributable to their antioxidant, anti-inflammation and anti-tumor properties. LCNPs were synthesized using the one-pot and green synthesis system with levan. For production of nanoparticles, levan plays a role as a stabilizing and reducing agent. Fourier transform infrared spectroscopy (FT-IR) analysis showed that LCNPs successfully synthesized. The morphology and size of nanoparticles were confirmed by transmission electron microscopy (TEM) and dynamic light scattering (DLS). LCNPs have good water solubility and stability. The conjugation of levan with cerium oxide nanoparticles improved antioxidant activity. Moreover the level of ROS was reduced after treatment of LCNPs to H2O2 stimulated NIH3T3 cells. These results demonstrate that the LCNPs are useful for applying of treatment of ROS induced diseases.
Hazards Monitoring Bionano Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea. Electronic address: kimsj@kribb.re.kr.
Sun-Jung
SJ
Kim
Hazards Monitoring Bionano Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea; BioNano Health Guard Research Center, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea. Electronic address: chungbh@kribb.re.kr.
Bong Hyun
BH
Chung
D000818:Animals; D002384:Catalysis; D002563:Cerium / Q000737:chemistry* / Q000633:toxicity; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000633:toxicity; D005630:Fructans / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D051379:Mice; D041681:NIH 3T3 Cells; D053758:Nanoparticles
D016166:Free Radical Scavengers; D005630:Fructans; D002563:Cerium; C030583:ceric oxide; C072599:levan
Antioxidant; Cerium oxide; Levan; Nanoparticles; ROS