Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of HeLa cervical cancer cells.
The inhibitory effect of 13 taxanes isolated from the Chinese yew (Taxus chinensis var. mairei) on the proliferation of human cervical cancer HeLa cells were examined using an MTT assay. Four compounds having a hydrophobic cinnamate side chain showed antiproliferative activity, which may be due to increased cell permeability.
a Department of Hematology , Fourth Hospital of Hebei Medical University , Shijiazhuang , China.
Hai-Sheng
HS
Liu
a Department of Hematology , Fourth Hospital of Hebei Medical University , Shijiazhuang , China.
Yu-Huan
YH
Gao
a Department of Hematology , Fourth Hospital of Hebei Medical University , Shijiazhuang , China.
Li-Hong
LH
Liu
b Department of Medical Oncology , Fourth Hospital of Hebei Medical University , Shijiazhuang , China.
Wei
W
Liu
c Department of Forensic Medicine , Hebei Medical University , Shijiazhuang , China.
Qing-Wen
QW
Shi
c Department of Forensic Medicine , Hebei Medical University , Shijiazhuang , China.
Mei
M
Dong
d Department of Health and Nutrition , Wayo Women's University , Ichikawa , Japan.
Toshikazu
T
Suzuki
e Graduate School of Environmental & Life Science, Okayama University , Okayama , Japan.
Hiromasa
H
Kiyota
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D043823:Taxoids / Q000737:chemistry*; D020946:Taxus / Q000737:chemistry*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D004224:Diterpenes; D043823:Taxoids; C080625:taxane
HeLa cells; Taxus chinensis var. mairei; antiproliferative activity; apoptosis; taxanes