Platelet-Rich Fibrin Combined With 1.2% Atorvastatin for Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial.
Platelet-rich fibrin (PRF), a second-generation platelet concentrate, and atorvastatin (ATV), a potent member of the statin group, are known to promote tissue regeneration. The current study is designed to evaluate combined efficacy of PRF and 1.2% ATV gel with open flap debridement (OFD) in treatment of intrabony defects (IBDs) in individuals with chronic periodontitis (CP).



Ninety-six individuals with single defects were categorized into three groups: 1) OFD with PRF; 2) OFD with PRF + 1.2% ATV; and 3) OFD alone. Clinical parameters: 1) site-specific plaque index; 2) modified sulcus bleeding index; 3) probing depth (PD); 4) relative clinical attachment level (rCAL); and 5) gingival marginal level were recorded at baseline before surgery and 9 months postoperatively. Percentage radiographic IBD depth reduction was evaluated at baseline and 9 months.



PRF + 1.2% ATV and PRF alone showed significantly greater PD reduction and rCAL gain compared with OFD alone at 9 months. Furthermore, PRF + 1.2% ATV showed a similar percentage radiographic defect depth reduction (50.96% ± 4.88%) compared with PRF alone (47.91% ± 4.79%), and a greater reduction compared with OFD alone (5.54% ± 1.71%) at 9 months.



PRF + 1.2% ATV showed similar improvements in clinical parameters with a greater percentage radiographic defect depth reduction compared with PRF alone in treatment of IBDs in individuals with CP. Thus, 1.2% ATV failed to augment the regenerative potential of PRF alone in periodontal IBDs.
Department of Periodontics, Dr. D.Y. Patil Dental College and Hospital, Pimpri, Pune, Maharashtra, India.
Santosh S
SS
Martande
Department of Periodontics, Vydehi Institute of Dental Sciences and Research Center, Bangalore, India.
Minal
M
Kumari
Department of Periodontics, Government Dental College & Research Institute, Bangalore, India.
A R
AR
Pradeep
Department of Periodontics, Government Dental College & Research Institute, Bangalore, India.
Sonender Pal
SP
Singh
Department of Periodontics, Government Dental College & Research Institute, Bangalore, India.
Deepak Kumar
DK
Suke
Department of Periodontics, Government Dental College & Research Institute, Bangalore, India.
C N
CN
Guruprasad
D016301:Alveolar Bone Loss; D000069059:Atorvastatin / Q000627:therapeutic use*; D055113:Chronic Periodontitis / Q000628:therapy*; D005337:Fibrin; D006801:Humans; D000073183:Platelet-Rich Fibrin
D005337:Fibrin; D000069059:Atorvastatin
Atorvastatin; biologic factors; periodontal bone loss; periodontal dressing; periodontal regeneration; platelet rich fibrin