Soluble TREM-1 as a diagnostic and prognostic biomarker in patients with septic shock: an observational clinical study.
OBJECTIVE
The impact of TREM-1-mediated inflammation was investigated in different inflammatory settings.


METHODS
Secondary analyses of an observational clinical pilot study, including 60 patients with septic shock, 30 postoperative controls and 30 healthy volunteers.


RESULTS
Plasma levels of sTREM-1 were found to identify patients with septic shock more effectively than procalcitonin and C-reactive protein. Moreover, sTREM-1 was identified to be an early predictor for survival in patients with septic shock.


CONCLUSIONS
Due to its diagnostic as well as prognostic value in sepsis syndrome, implementation of sTREM-1 measurements in routine diagnostics should be taken into account.
a Department of Anesthesiology , Heidelberg University Hospital , Heidelberg , Germany.
Thorsten
T
Brenner
a Department of Anesthesiology , Heidelberg University Hospital , Heidelberg , Germany.
Florian
F
Uhle
b Department of Medicine I and Clinical Chemistry , Heidelberg University Hospital , Heidelberg , Germany.
Thomas
T
Fleming
a Department of Anesthesiology , Heidelberg University Hospital , Heidelberg , Germany.
Matthias
M
Wieland
a Department of Anesthesiology , Heidelberg University Hospital , Heidelberg , Germany.
Thomas
T
Schmoch
a Department of Anesthesiology , Heidelberg University Hospital , Heidelberg , Germany.
Felix
F
Schmitt
a Department of Anesthesiology , Heidelberg University Hospital , Heidelberg , Germany.
Karsten
K
Schmidt
a Department of Anesthesiology , Heidelberg University Hospital , Heidelberg , Germany.
Aleksandar R
AR
Zivkovic
c Institute of Medical Biometry and Informatics , University of Heidelberg , Heidelberg , Germany.
Thomas
T
Bruckner
a Department of Anesthesiology , Heidelberg University Hospital , Heidelberg , Germany.
Markus A
MA
Weigand
a Department of Anesthesiology , Heidelberg University Hospital , Heidelberg , Germany.
Stefan
S
Hofer
D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D006801:Humans; D007249:Inflammation / Q000097:blood; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011379:Prognosis; D011971:Receptors, Immunologic / Q000097:blood*; D012772:Shock, Septic / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D012995:Solubility; D013534:Survival; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
D015415:Biomarkers; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
(soluble) triggering receptor expressed on myeloid cells; Diagnosis; prognosis; sepsis; septic shock; severe sepsis