The retinoblastoma protein: multitasking to suppress tumorigenesis.
Tumor suppressor activity of the retinoblastoma protein pRB is preserved despite loss of interaction with E2F transcription factors (E2F) or proteins harboring a leucine-x-cysteine-x-glutamic acid motif (LxCxE, where x is any amino acid). This indicates that pRB uses several parallel pathways to suppress tumorigenesis, which may also include E2F- and LxCxE-independent interactions.
Division of Biological Stress Response; The Netherlands Cancer Institute ; Amsterdam, The Netherlands.
Tinke L
TL
Vormer
Department of Biology; University of Copenhagen ; Copenhagen, Denmark.
Jacob B
JB
Hansen
Division of Biological Stress Response; The Netherlands Cancer Institute ; Amsterdam, The Netherlands.
Hein
H
Te Riele