Sonic Hedgehog factor Gli1: As good as resistant.
Chemoresistance remains a major impediment in cancer therapy. Although major progress has been made in understanding the mechanisms underlying resistance in cancer, there is still more to learn. Our studies provide evidence that Gli1 drives a novel form of drug resistance involving Phase II drug metabolism enzymes, specifically the UGT1A family.
Institute for Research in Immunology and Cancer; University of Montreal ; Montreal, QC Canada.
Hiba Ahmad
HA
Zahreddine
Institute for Research in Immunology and Cancer; University of Montreal ; Montreal, QC Canada.
Biljana
B
Culjkovic-Kraljacic
Institute for Research in Immunology and Cancer; University of Montreal ; Montreal, QC Canada.
Katherine Lb
KL
Borden
Gli1; UGT1A; Vismodegib; cancer; cytarabine; drug resistance; eIF4E; glucuronidation; ribavirin