The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression.
The p50 subunit of nuclear factor-kappa B (NF-κB) is generated from processing of the p105 precursor. We identified KIP1 ubiquitination-promoting complex 1 (KPC1) as the ubiquitin (Ub) ligase mediating this process. Overexpression of KPC1 results in tumor suppression, probably due to the generation of p50-p50 homodimers. It appears that high levels of KPC1 and nuclear p50 are important for maintaining the non-malignant state.
The David and Janet Polak Cancer and Vascular Biology Research Center; The Rappaport Faculty of Medicine and Research Institute; Technion - Israel Institute of Technology ; Haifa, Israel.
Yelena
Y
Kravtsova-Ivantsiv
The David and Janet Polak Cancer and Vascular Biology Research Center; The Rappaport Faculty of Medicine and Research Institute; Technion - Israel Institute of Technology ; Haifa, Israel.
Aaron
A
Ciechanover
26S proteasome; KPC1; NF-κB; p105; tumor growth regulation; ubiquitin