Oxygen Sensing in Early Life.
From birth, animals should possess functional machinery to appropriately regulate its respiration. This machinery has to detect the available oxygen quantity in order to efficiently modulate breathing movements in accordance with body requirements. The chemosensitivity process responsible for this detection is known to be mainly performed by carotid bodies. However, pulmonary neuroendocrine cells, which are mainly gathered in neuroepithelial bodies, also present the capability to exert chemosensitivity. The goal of this article is to put in perspective the potential complementarity in the activity of these two peripheral chemosensors in the context of neonatal oxygen chemosensitivity.
Institut de Neurosciences de la Timone-Equipe IMAPATH, CERIMED, UMR 7289 CNRS & Aix-Marseille Université, 27 Boulevard Jean Moulin,13385, Marseille Cedex 05, France. celine.caravagna@univ-amu.fr.
Céline
C
Caravagna
Faculté de Médecine, Université Laval, Pavillon Ferdinand-Vandry, Room 4645-A,1050, Avenue de la Médecine, Quebec, QC, G1V 0A6, Canada.
Tommy
T
Seaborn
D001933:Brain Stem / Q000502:physiology; D002344:Carotid Body / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000503:physiopathology; D008168:Lung / Q000166:cytology; D055099:Neuroendocrine Cells / Q000502:physiology*; D046568:Neuroepithelial Bodies / Q000502:physiology*; D010100:Oxygen / Q000378:metabolism*; D012119:Respiration
D010100:Oxygen
Breathing; Chemosensing; Lungs; Neuroendocrine cells; Neuroepithelial bodies; Newborn