Reactive oxygen species: The good, the bad, and the enigma.
Work carried out primarily in the laboratory of Fabrizio d'Adda di Fagagna unveils the mitogenic properties of Ras-induced reactive oxygen species (ROS) and their relationship with the DNA damage response. Combined data from studies of cultured cells, zebrafish models, and clinical material consistently support a role of the RAS-RAC1-NOX4 axis in ROS induction, hyperproliferation, and senescence.
IFOM Foundation - FIRC Institute of Molecular Oncology Foundation ; Milan, Italy.
Müge
M
Ogrunc
DNA Damage Response (DDR); NADPH oxidase (Nox); oncogene-induced cellular senescence; reactive oxygen species (ROS)