pH-Sensitive Poly(histidine methacrylamide).
This research reports a synthetic amino acid based zwitterionic poly(histidine methacrylamide) (PHisMA), which possesses switchability among zwitterionic, anionic, and cationic states, pH-dependent antifouling properties, and chelation capability to multivalent metal ions. The PHisMA polymer brush surface shows good antifouling properties to resist protein adsorption and bacterial attachment in its zwitterionic state at pH 5. This study also demonstrates that the solution acidity significantly affects the mechanical properties of PHisMA hydrogels. PHisMA hydrogels show higher viscoelastic properties and lower swelling ratios in the zwitterionic state at pH 4 and pH 5, compared to higher or lower pH conditions. It was discovered that PHisMA can chelate multivalent metal ions, such as Ca(2+), Mg(2+), Cu(2+), Ni(2+) and Fe(3+). This study provides us a better understanding of structure-property relationships of switchable zwitterionic polymers. PHisMA can potentially be adapted for a broad range of applications including wound care, water treatment, bioseparation, coating, drug and gene delivery carriers, etc.
Huifeng
H
Wang
Haiyan
H
Wu
Chen-Jung
CJ
Lee
Xia
X
Lei
Jiang
J
Zhe
Key Laboratory of Carbon Fiber and Functional Polymers, Beijing University of Chemical Technology, Ministry of Education , Beijing 10029, China.|Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology , Beijing 100029, China.
Fujian
F
Xu
School of Pharmaceutical Engineering, Dalian University of Technology , Dalian, Liaoning Province, 116024, China.
Fang
F
Cheng
Gang
G
Cheng
D002614:Chelating Agents / Q000737:chemistry*; D006639:Histidine / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008670:Metals / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D013329:Structure-Activity Relationship
D002614:Chelating Agents; D020100:Hydrogels; D008670:Metals; D011109:Polymethacrylic Acids; C033223:polyhistidine; D006639:Histidine