Failure to increase the thickness of thin endometria with intrauterine infusion of granulocyte colony stimulating factor (G-CSF).
OBJECTIVE
To corroborate or refute a previous study suggesting that intrauterine infusion of granulocyte colony stimulating factor (G-CSF) could significantly improve endometrial thickness into more fertile levels when the endometrial thickness was ≤ five mm.


METHODS
Three women whose endometrial thickness never exceeded five mm on the in vitro fertilization-embryo transfer (IVF-ET) cycle or subsequent attempted frozen ETs using graduated estradiol had intrauterine infusion of G-CSF to the estradiol regimen.


RESULTS
Not one of the three women improved the endometrial thickness beyond five mm and none conceived on the G-CSF cycle. One woman had a subsequent pregnancy following a frozen ET with only a four-mm thickness with no infusion of G-CSF.


CONCLUSIONS
These data do not confirm the efficacy of intrauterine infusion of G-CSF for poor endometrial thickness. Perhaps only certain cases will respond. A larger series could take time to accumulate since other studies have shown that only 0.3% of women with ≤ five mm endometrial thickness in the late proliferative phase during an IVF-ET cycle will not improve the endometrial thickness > five mm using graduated estradiol protocols.
J H
JH
Check
J K
JK
Choe
D
D
Summers-Chase
D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D004624:Embryo Transfer / Q000379:methods; D004717:Endometrium / Q000000981:diagnostic imaging*; D004958:Estradiol / Q000627:therapeutic use; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007263:Infusions, Parenteral; D009929:Organ Size; D011247:Pregnancy; D014463:Ultrasonography
D004967:Estrogens; D016179:Granulocyte Colony-Stimulating Factor; D004958:Estradiol