Systolic blood pressure during recovery from exercise is related to flow-mediated dilatation in patients with coronary artery disease.
OBJECTIVE
To assess the relationship between exercise-induced parameters obtained from the routine exercise stress testing (EST) and flow-mediated vasodilatation (FMD) as an index of endothelial function.


METHODS
A retrospective study.


METHODS
Kurume University Medical Center, Kurume, Japan.


METHODS
All patients with stable coronary artery disease (CAD) who were admitted to Kurume University Medical Center.


METHODS
Results of EST and FMD.


RESULTS
We studied 66 patients (35 male/31 female) with CAD. All patients underwent symptom-limited EST and measurement of FMD. Exercise parameters included exercise-induced heart rate and systolic blood pressure (SBP). FMD did not differ between male and female groups. In univariate analysis, determinants of FMD included age and the change in SBP at 1 min after exercise. In Cox hazard model analysis, the change in SBP at 1 min after exercise (p=0.011) was an independent determinant of FMD. FMD in patients with abnormal SBP response group was significantly lower than that in normal SBP response group (4.2±1.8 ns. 6.1±2.6%, p<0.05).


CONCLUSIONS
These findings suggest that SBP during recovery from exercise is associated with endothelial function in patients with CAD.
Department of Cardiology , Kurume University Medical Center , Kurume, Kumamoto , Japan.
Yasuhiro
Y
Nishiyama
Department of Cardiology , Kurume University Medical Center , Kurume, Kumamoto , Japan.
Akiko
A
Sakaue
Department of Cardiology , Kurume University Medical Center , Kurume, Kumamoto , Japan.
Sumitake
S
Matsuo
Department of Cardiology , Kurume University Medical Center , Kurume, Kumamoto , Japan.
Hiroshi
H
Niiyama
Department of Cardiology , Kurume University Medical Center , Kurume, Kumamoto , Japan.
Haruhito
H
Harada
Department of Cardiology , Kurume University Medical Center , Kurume, Kumamoto , Japan.
Atsushi
A
Katoh
Department of Cardiology , Kurume University Medical Center , Kurume, Kumamoto , Japan.
Hisao
H
Ikeda
Coronary Artery Disease