Toward anti-Markovnikov 1-Alkyne O-Phosphoramidation: Exploiting Metal-Ligand Cooperativity in a 1,3-N,O-Chelated Cp*Ir(III) Complex.
Metal-ligand cooperation between iridium(III) and a 1,3-N,O-chelating phosphoramidate ligand has been used to develop a protocol for the intermolecular O-phosphoramidation of 1-alkynes. This selective C-O bond-forming reaction differs from that of standard amidation reactions, highlighting the ability to control N- or O-functionalization based on judicious choice of N,O-chelating ligand and metal center. Advances toward the development of catalytic anti-Markovnikov O-phosphoramidation using iridium(III), including characterization of rare reactive intermediates that invoke 1,3-bidentate donor ligand hemilability, are disclosed.
Department of Chemistry, The University of British Columbia , 2036 Main Mall, Vancouver, British Columbia, Canada V6T 1Z1.
Marcus W
MW
Drover
Department of Chemistry, The University of British Columbia , 2036 Main Mall, Vancouver, British Columbia, Canada V6T 1Z1.
Jennifer A
JA
Love
Department of Chemistry, The University of British Columbia , 2036 Main Mall, Vancouver, British Columbia, Canada V6T 1Z1.
Laurel L
LL
Schafer