Clonic Seizures in GAERS Rats after Oral Administration of Enrofloxacin.
The aim of this study was to evaluate the effect of oral enrofloxacin on the epileptic status of Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Five adult female GAERS rats, with implanted extradural electrodes for EEG monitoring, were declared free of clonic seizures after an 8-wk observation period. Enrofloxacin was then added to their drinking water (42.5 mg in 750 mL), and rats were observed for another 3 days. The number of spike-and-wave discharges and mean duration of a single discharge did not differ before and after treatment, but 2 of the 5 rats developed clonic seizures after treatment. Enrofloxacin should be used with caution in GAERS rats because it might induce clonic seizures.
Translational Research and Animal Clinical Trial Study (TRACTS) Group, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, Victoria, Australia. Bauquier@unimelb.edu.au.
Sebastien H
SH
Bauquier
Department of Clinical Neurosciences, St Vincent's Hospital, Fitzroy, Victoria, Australia, Faculty of Medicine, The University of Melbourne, Parkville, Victoria, Australia.
Jonathan L
JL
Jiang
Department of Electrical and Electronic Engineering, The University of Melbourne, Parkville, Victoria, Australia.
Alan
A
Lai
Department of Clinical Neurosciences, St Vincent's Hospital, Fitzroy, Victoria, Australia, Faculty of Medicine, The University of Melbourne, Parkville, Victoria, Australia.
Mark J
MJ
Cook
D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects*; D004195:Disease Models, Animal; D004569:Electroencephalography; D000077422:Enrofloxacin; D004832:Epilepsy, Absence / Q000150:complications / Q000235:genetics; D005260:Female; D024841:Fluoroquinolones / Q000009:adverse effects*; D020022:Genetic Predisposition to Disease; D010865:Pilot Projects; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D000077422:Enrofloxacin