Meeting Report Europhosphatase 2015: Phosphatases as Drug Targets in Cancer.
Phosphatases are key regulators of cellular signaling and as such play an important role in nearly all cellular processes governing diseases, including cancer. However, due to their highly conserved structure and highly charged and reactive catalytic site, they have been regarded as "undruggable." Fortunately, during the recent Europhosphatase meeting (Turku, Finland), it became clear that phosphatases can no longer be ignored as potential targets in cancer therapy. As reactivation of tumor-suppressor phosphatases or direct inhibition of phosphatases acting as oncogenes is becoming available, this class of enzymes can now be considered as feasible drug targets. Cancer Res; 76(2); 193-6. ©2016 AACR.
Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. g.fuhler@erasmusmc.nl.
Elmer
E
Hoekstra
Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Maikel P
MP
Peppelenbosch
Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Gwenny M
GM
Fuhler
D000970:Antineoplastic Agents / Q000737:chemistry*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000201:enzymology; D020134:Catalytic Domain; D004791:Enzyme Inhibitors / Q000737:chemistry*; D005060:Europe; D005260:Female; D005387:Finland; D016147:Genes, Tumor Suppressor; D015894:Genome, Human; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D010749:Phosphoprotein Phosphatases / Q000378:metabolism* / Q000627:therapeutic use; D054648:Protein Phosphatase 2 / Q000378:metabolism; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000378:metabolism; D015398:Signal Transduction
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1