Bioresorbable Stents in PCI.
The evolution of percutaneous coronary intervention has been considerable. Coronary stents were introduced to avoid vessel recoil and reduce acute and late vessel complications. Later, drug-eluting stents were developed to decrease the neointimal hyperplasia associated with bare metal stents in order to reduce restenosis. However, very late stent thrombosis remains problematic, and the permanent presence of a metal stent could be associated with local inflammation and impaired vascular physiology. Thus, bioresorbable stents have been developed, to prevent recoil initially when this risk is the highest, with subsequent degradation over time, to avoid long-term complications of the presence of stents in the coronary vasculature. Here, we review the current status of bioresorbable stents in percutaneous coronary intervention (PCI), with focus on the platforms that have been studied the most: ABSORB, DESolve, and DREAMS. In terms of clinical outcomes, bioresorbable stents have not yet shown superiority compared with current generation drug-eluting stents, but rather a signal of increased stent thrombosis. Further development and longer-term studies are needed before the routine implementation of bioresorbable stents in clinical practice.
Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden. daniel.lindholm@ucr.uu.se.|Uppsala Clinical Research Center, Dag Hammarskjölds väg 14B, SE-752 37, Uppsala, Sweden. daniel.lindholm@ucr.uu.se.
Daniel
D
Lindholm
Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.|Uppsala Clinical Research Center, Dag Hammarskjölds väg 14B, SE-752 37, Uppsala, Sweden.
Stefan
S
James
D020341:Absorbable Implants / Q000009:adverse effects / Q000706:statistics & numerical data*; D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000601:surgery*; D023903:Coronary Restenosis / Q000517:prevention & control*; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000295:instrumentation*; D011474:Prosthesis Design; D016896:Treatment Outcome
Bioresorbable stents; Coronary artery disease; Percutaneous coronary intervention