Bio-effect of nanoparticles in the cardiovascular system.
Nanoparticles (NPs; < 100 nm) are increasingly being applied in various fields due to their unique physicochemical properties. The increase in human exposure to NPs has raised concerns regarding their health and safety profiles. The potential correlation between NP exposure and several cardiovascular (CV) events has been demonstrated. The aim of this review is to provide a comprehensive evaluation of the current knowledge regarding the bio-toxic impacts of titanium oxide, silver, silica, carbon black, carbon nanotube, and zinc oxide NPs exposure on the CV system in terms of in vivo and in vitro experiments, which is not fully understood presently. Moreover, the potential toxic mechanisms of NPs in the CV system that are still being questioned are elaborately discussed, and the underlying capacity of NPs used in medicine for CV events are summarized. It will be an important instrument to extrapolate relevant data for human CV risk evaluation and management. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2881-2897, 2016.
Department of Applied Biology, School of Basic Medical and Biological Sciences, Soochow University, RM702-2303, Renai Road No. 199, Dushuhu Higher Edu. Town, Suzhou, 215123, People's Republic of China.
Xiaohong
X
Yu
Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental Protection, Huaiyin Normal University, Huaian, 223300, China. hongfsh_cn@sina.com.|Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, Huaiyin Normal University, Huaian, 223300, China. hongfsh_cn@sina.com.
Fashui
F
Hong
Department of Applied Biology, School of Basic Medical and Biological Sciences, Soochow University, RM702-2303, Renai Road No. 199, Dushuhu Higher Edu. Town, Suzhou, 215123, People's Republic of China.
Yu-Qing
YQ
Zhang
D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology; D053758:Nanoparticles / Q000633:toxicity*; D037742:Nanotubes, Carbon / Q000633:toxicity; D018384:Oxidative Stress / Q000187:drug effects; D012822:Silicon Dioxide / Q000633:toxicity*; D012834:Silver / Q000633:toxicity*; D014025:Titanium / Q000633:toxicity*; D015032:Zinc / Q000633:toxicity
D037742:Nanotubes, Carbon; C009495:titanium dioxide; D012834:Silver; D012822:Silicon Dioxide; D014025:Titanium; D015032:Zinc
bio-toxicity; cardiovascular system; medical application; nanoparticles; toxic mechanism