Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk.
BACKGROUND
Protein-protein interaction and signaling crosstalk contribute to the regulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) and broaden their cellular function.


METHODS
This review covers key historic discoveries and recent advances in our understanding of the broad function of PXR and CAR and their regulation by protein-protein interaction and signaling crosstalk.


CONCLUSIONS
PXR and CAR were first discovered as xenobiotic receptors; however, it is clear that PXR and CAR perform a much broader range of cellular functions through protein-protein interaction and signaling crosstalk, which typically mutually affect the function of all the partners involved. Future research on PXR and CAR should, therefore, look beyond their xenobiotic function.
a Department of Chemical Biology and Therapeutics , St. Jude Children's Research Hospital , Memphis , TN , USA.
Peter
P
Oladimeji
a Department of Chemical Biology and Therapeutics , St. Jude Children's Research Hospital , Memphis , TN , USA.
Hongmei
H
Cui
a Department of Chemical Biology and Therapeutics , St. Jude Children's Research Hospital , Memphis , TN , USA.
Chen
C
Zhang
a Department of Chemical Biology and Therapeutics , St. Jude Children's Research Hospital , Memphis , TN , USA.
Taosheng
T
Chen
D000818:Animals; D000090702:Constitutive Androstane Receptor; D006801:Humans; D008099:Liver / Q000378:metabolism; D000077297:Pregnane X Receptor; D020239:Receptor Cross-Talk / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D015262:Xenobiotics / Q000494:pharmacology
D000090702:Constitutive Androstane Receptor; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D015262:Xenobiotics
Pregnane X receptor; constitutive androstane receptor; protein-protein interaction; signaling crosstalk