Microdialysis as a way to measure antibiotics concentration in tissues.
As for all other drugs, antibiotics must reach their pharmacodynamic target in order to exert their effect, but because infection may occur in various tissues the distribution of antibiotics has always been of particular concern. In this article, we will first critically review the various methodologies available to study antibiotics tissue distribution, including microdialysis, secondly we will show how basic pharmacokinetic concepts may help to predict or interpret antibiotics tissue distribution and third we will address the question of linking antibiotics tissue distribution with their antimicrobial effect, using modern pharmacokinetic-pharmacodynamic methods.
Inserm U1070, Pôle Biologie Santé, 1 Rue Georges Bonnet, TSA 51106, 86073 Poitiers Cedex 9, France; Université de Poitiers, UFR Médecine-Pharmacie, 6, rue de la milétrie, TSA 51115, 86073 Poitiers Cedex, France; CHU Poitiers, Service de Toxicologie-Pharmacocinétique, 2 Rue de la milétrie, CS 90577, 86021 Poitiers, France.
Sandrine
S
Marchand
Inserm U1070, Pôle Biologie Santé, 1 Rue Georges Bonnet, TSA 51106, 86073 Poitiers Cedex 9, France; Université de Poitiers, UFR Médecine-Pharmacie, 6, rue de la milétrie, TSA 51115, 86073 Poitiers Cedex, France.
Alexia
A
Chauzy
Inserm U1070, Pôle Biologie Santé, 1 Rue Georges Bonnet, TSA 51106, 86073 Poitiers Cedex 9, France; Université de Poitiers, UFR Médecine-Pharmacie, 6, rue de la milétrie, TSA 51115, 86073 Poitiers Cedex, France; CHU Poitiers, Département d⿿Anesthésie Réanimation, 2 Rue de la milétrie, CS 90577, 86021 Poitiers, France.
Claire
C
Dahyot-Fizelier
Inserm U1070, Pôle Biologie Santé, 1 Rue Georges Bonnet, TSA 51106, 86073 Poitiers Cedex 9, France; Université de Poitiers, UFR Médecine-Pharmacie, 6, rue de la milétrie, TSA 51115, 86073 Poitiers Cedex, France; CHU Poitiers, Service de Toxicologie-Pharmacocinétique, 2 Rue de la milétrie, CS 90577, 86021 Poitiers, France. Electronic address: william.couet@univ-poitiers.fr.
William
W
Couet
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D017551:Microdialysis; D008954:Models, Biological; D011237:Predictive Value of Tests; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents
Antibiotics; Distribution; Microdialysis; Pharmacodynamics; Pharmacokinetics; Tissue