A Six-Stage Workflow for Robust Application of Systems Pharmacology.
Quantitative and systems pharmacology (QSP) is increasingly being applied in pharmaceutical research and development. One factor critical to the ultimate success of QSP is the establishment of commonly accepted language, technical criteria, and workflows. We propose an integrated workflow that bridges conceptual objectives with underlying technical detail to support the execution, communication, and evaluation of QSP projects.
Translational & Systems Pharmacology, PKPD, Genentech, South San Francisco, California, USA.
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K
Gadkar
Translational & Systems Pharmacology, PKPD, Genentech, South San Francisco, California, USA.
D C
DC
Kirouac
Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York.
D E
DE
Mager
Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.|Certara QSP, Canterbury, UK.
P H
PH
van der Graaf
Translational & Systems Pharmacology, PKPD, Genentech, South San Francisco, California, USA.
S
S
Ramanujan
D019295:Computational Biology / Q000379:methods*; D003628:Database Management Systems; D006801:Humans; D010601:Pharmacology, Clinical / Q000379:methods*; D049490:Systems Biology / Q000379:methods*; D057188:Workflow