Soluble CD40 ligand in haemodialysis patients: survival impact and cardiovascular prognostic role.
BACKGROUND
Soluble CD40 ligand (sCD40l) can predict cardiovascular events (CVE) and mortality in haemodialysis (HD) patients (short-, medium-term follow-up studies).


OBJECTIVE
To evaluate the relationship between sCD40l and survival, CVE and mortality in HD patients on long-term follow-up.


METHODS
We registered 46 HD patients' baseline characteristics, mortality and CVE for 108 months.


RESULTS
SCD40l correlated positively with C-reactive protein, was higher in survivors, but had no impact on survival and was not predictive for CVE or CV mortality.


CONCLUSIONS
The levels of sCD40l have no influence on survival or CVE and mortality in HD patients in a long-term follow-up.
a Department of Nephrology , University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca , Romania.
Crina
C
Rusu
b Nefromed Dialysis Center , Cluj-Napoca , Romania.
Simona
S
Racasan
a Department of Nephrology , University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca , Romania.
Diana
D
Moldovan
a Department of Nephrology , University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca , Romania.
Ina Maria
IM
Kacso
a Department of Nephrology , University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca , Romania.
Alina
A
Potra
c Department of Statistics , University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca , Romania.
Cosmina Ioana
CI
Bondor
b Nefromed Dialysis Center , Cluj-Napoca , Romania.
Ioan Mihai
IM
Patiu
a Department of Nephrology , University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca , Romania.
Dan
D
Vladutiu
a Department of Nephrology , University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca , Romania.
Mirela Gherman
MG
Caprioara
D002097:C-Reactive Protein / Q000032:analysis; D023201:CD40 Ligand / Q000097:blood*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D015996:Survival Rate
D023201:CD40 Ligand; D002097:C-Reactive Protein
Cardiovascular disease; immunotoxicity; renal disease