[Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): clinical manifestations and multidisciplinary management].
Hereditary hemorrhagic telangiectasia (HHT), or Osler- Weber-Rendu syndrome, is a rare genetic disorder with autosomal dominant inheritance, characterized by recurrent epistaxis, mucocutaneous telangiectasia and visceral arteriovenous malformations (AVMs), which may lead to severe complications. The diagnosis of HHT is often delayed due to the rarity of the disease, and the variety of clinical manifestations. The management of HHT includes systematic screening for visceral AVMs at regular intervals, preventive interventions to reduce the risk of complications, and symptomatic measures. A multidisciplinary standardized program in specialised centers may improve the management of patients with HHT.
Cecilia
C
Frigerio
Nicole
N
Aebischer
David
D
Baud
Luisa
L
Bonafe
Florence
F
Fellmanne
Christos
C
Ikonomidis
Lucia
L
Mazzolai
Patrik
P
Michel
Cristina
C
Nichita
Salah Dine
SD
Qanadli
Romain
R
Lazor
D005838:Genotype; D006801:Humans; D010348:Patient Care Team; D010641:Phenotype; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy