Systematic review of green tea epigallocatechin gallate in reducing low-density lipoprotein cholesterol levels of humans.
We conducted a systematic review of the literature for the ability of green tea epigallocatechin gallate (EGCG) to lower low-density lipoprotein cholesterol (LDL-C). Study subjects were limited to healthy individuals and randomized, controlled trials on human serum lipid levels, especially LDL-C, conducted. A total of 17 trials (n = 1356) met all of the inclusion criteria. According to weighted mean differences for changes from baseline with 95% confidence intervals (CI), 107-856 mg/d of EGCG for 4 to 14 weeks reduced LDL-C by -9.29 mg/dl (95% CI, -12.27 to -6.31). Sub-analysis was performed to compare the EGCG lowering effect on LDL-C between non-obese and obese subjects, EGCG dose, baseline of LDL-C levels, or BMI. We concluded that consumption of green tea EGCG resulted in a significant reduction of LDL-C at any baseline level and any dose between 107 and 856 mg/d, and the effect size was slightly dependent on the baseline lipid level of the subjects.
a Food Engineering Division , National Food Research Institute , Ibaraki , Japan ;
Yuko
Y
Momose
b Food Function Division , National Food Research Institute , Ibaraki , Japan.
Mari
M
Maeda-Yamamoto
a Food Engineering Division , National Food Research Institute , Ibaraki , Japan ;
Hiroshi
H
Nabetani
D015992:Body Mass Index; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008078:Cholesterol, LDL / Q000097:blood*; D006801:Humans; D009765:Obesity / Q000097:blood; D010936:Plant Extracts / Q000494:pharmacology; D016032:Randomized Controlled Trials as Topic; D013662:Tea / Q000737:chemistry*
D008078:Cholesterol, LDL; D010936:Plant Extracts; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate
Catechin; flavonoid; lipid profile; polyphenol