Primary Retroperitoneal Cystoadenocarcinoma: A Systematic Review.
OBJECTIVE
The aim of this study was to perform a systematic review on primary retroperitoneal cystoadenocarcinoma (PRC), which is an extremely rare disease.


METHODS
According to PRISMA guidelines, all the literature about PRC from 1977 to 2015 was reviewed. Thirty articles were selected; characteristics of the patients were collected and described; time to recurrence and overall survival (OS) were investigated when available.


RESULTS
Thirty seven patients were included of whom 33 were females; the median age at presentation was 43. PRC was more common in postmenopausal women. Surgery was the standard therapy; the role of chemotherapy and/or radiotherapy was uncertain. Thirty percent of the patients relapsed after 58 months from the surgery; the rupture of the cyst occurred in 13% of the cases and it was associated with poor prognosis as well as premenopausal status. At 125 months from the diagnosis, 72% of the patients were alive and the median OS was not reached.


CONCLUSIONS
The present systematic review about PRC is the first performed until the date of drafting this paper. We described some clinical features of PRC and their possible prognostic value. No conclusive data can be presented due to the small population analyzed and to publication bias.
Medical Oncology Unit, University Hospital of Parma, Parma, Italy.
Benedetta
B
Pellegrino
Angelica
A
Sikokis
Melissa
M
Bersanelli
Alessandro
A
Leonetti
Francesco
F
Leonardi
Giovanni
G
Di Meglio
Sebastiano
S
Buti
D003536:Cystadenocarcinoma / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy