Novel insights into the mechanisms of mitotic spindle assembly by NEK kinases.
The mitotic spindle is the apparatus upon which chromosomes are segregated during cell division. We have discovered new roles for two members of the NIMA-related kinase (NEK) family in different molecular processes of spindle assembly. Moreover, loss of these proteins leads to segregation errors that drive cancer progression.
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital , Toronto, Ontario, Canada.
Suzanna L
SL
Prosser
University of Leicester, Department of Biochemistry , Leicester, UK.
Laura
L
O'Regan
University of Leicester, Department of Biochemistry , Leicester, UK.
Andrew M
AM
Fry
Centrosome separation; Hsp72; Nek5; Nek6; mitosis; spindle assembly