Spectral karyotyping reveals a comprehensive karyotype in an adult acute lymphoblastic leukemia.
Cytogenetic abnormalities are frequently detected in patients with acute lymphoblastic leukemia (ALL). Comprehensive karyotype was related to poor prognosis frequently in ALL. We present a comprehensive karyotype in an adult ALL by spectral karyotyping (SKY) and R-banding. SKY not only conﬁrmed the abnormalities previously seen by R-banding but also improved comprehensive karyotype analysis with the following result 47,XY,+9, ins(1;5)(q23;q23q34) t(6;7)(q23;p13). Our report demonstrated that SKY is able to provide more information accurately for prediction of disease prognosis in adult ALL with comprehensive karyotype.
Department of Geriatric Hematology, General Hospital of PLA, Beijing, China.
Bo
B
Guo
Department of Geriatric Hematology, General Hospital of PLA, Beijing, China.
Hong Li
HL
Zhu
Department of Geriatric Hematology, General Hospital of PLA, Beijing, China.
Su Xia
SX
Li
Department of Geriatric Hematology, General Hospital of PLA, Beijing, China.
Xue Chun
XC
Lu
Department of Geriatric Hematology, General Hospital of PLA, Beijing, China.
Hui
H
Fan
Department of Geriatric Hematology, General Hospital of PLA, Beijing, China.
Wan Ming
WM
Da
SKY; acute lymphoblastic leukemia; comprehensive karyotype