A Case of Pigmented Mammary Paget's Disease.
Pigmented mammary Paget's disease is a uncommon clinicopathologic variant of mammary Paget's disease, and this mimics malignant melanoma both clinically and histopathologically. Herein, we report on a rare case of pigmented mammary Paget's disease. An 81-year-old woman presented with 2.5×1 cm sized, red and brown, eczematous plaque on her right areola, and she'd had this lesion for 3 years. Histopathology showed large, atypical cells with large nuclei and abundant pale cytoplasm throughout the epidermis. Dispersed melanocytes were noted in the epidermis and some of the Paget's cells contained melanin within their cytoplasm. Immunohistochemical studies demonstrated that the intraepidermal pagetoid cells were positive for cytokeratin 7; in contrast, they were negative for S-100, Periodic-acid Schiff (PAS), Alcian blue at PH 2.5, HMB-45 and carninoembryonic antigen (CEA). We recommend that pigmented mammary Paget's disease should be included in the differential diagnosis of pigmented lesions on the nipple.
Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.
Ji Eun
JE
Kim
Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.
Myung Seung
MS
Kang
Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.
Joung Soo
JS
Kim
Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.
Hee Joon
HJ
Yu
Pigmented mammary Paget's disease