Mismatch in cerebral blood flow and glucose metabolism after the forced swim stress in rats.
OBJECTIVE
Neuroimaging studies of depression considered as a stress-related disorder have shown uncoupling in regional cerebral blood flow (rCBF) and regional cerebral metabolic rate for glucose (rCMRglc). We hypothesised that the mismatch change of rCBF and rCMRglc could be a stress-related phenomenon.


METHODS
We exposed male rats to 15-min period of forced swim (FS), followed by the measurement of rCBF using N-isopropyl-4-[123I] iodoamphetamine (123I-IMP) and rCMRglc using 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG).


RESULTS
The uptake rate of 18F-FDG in the FS group showed a significant decrease in the prefrontal cortex (0.86±0.20%ID/g, p<0.01) and thalamus (0.77±0.17%ID/g, p<0.05) and tended to be lower in the hippocampus (0.58±0.13%ID/g) and cerebellum (0.59±0.13%ID/g) without overt alteration in the uptake rate of 123I-IMP.


CONCLUSIONS
The FS stress can cause mismatch change of rCBF and rCMRglc, which reflect a stress-related phenomenon.
1Department of Psychiatry,Hamamatsu University School of Medicine,Japan.
Yosuke
Y
Kameno
1Department of Psychiatry,Hamamatsu University School of Medicine,Japan.
Katsuaki
K
Suzuki
2Research Center for Child Mental Development,Hamamatsu University School of Medicine,Japan.
Shu
S
Takagai
3Research Center for Child Mental Development,University of Fukui,Japan.
Keiko
K
Iwata
3Research Center for Child Mental Development,University of Fukui,Japan.
Hideo
H
Matsuzaki
2Research Center for Child Mental Development,Hamamatsu University School of Medicine,Japan.
Kenji
K
Takahashi
1Department of Psychiatry,Hamamatsu University School of Medicine,Japan.
Tomoyasu
T
Wakuda
1Department of Psychiatry,Hamamatsu University School of Medicine,Japan.
Yasuhide
Y
Iwata
4Medical Photonics Research Center,Hamamatsu University School of Medicine,Japan.
Yasuhiro
Y
Magata
1Department of Psychiatry,Hamamatsu University School of Medicine,Japan.
Norio
N
Mori
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D005947:Glucose / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological / Q000378:metabolism* / Q000503:physiopathology*; D013550:Swimming
D005947:Glucose
depression; forced swim stress; rat; regional cerebral blood flow; regional cerebral metabolic rate for glucose