The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation.
Over the past decade, numerous advances have been made in the role and regulation of inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises a sensor, an adaptor, and a zymogen procaspase-1. The functional output of inflammasome activation includes secretion of cytokines, IL-1β and IL-18, and induction of an inflammatory form of cell death called pyroptosis. Recent studies have highlighted the intersection of this inflammatory response with fundamental cellular processes. Novel modulators and functions of inflammasome activation conventionally associated with the maintenance of homeostatic biological functions have been uncovered. In this review, we discuss the biological processes involved in the activation and regulation of the inflammasome.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105.
Deepika
0000-0003-3466-3630
D
Sharma
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105 thirumala-devi.kanneganti@stjude.org.
Thirumala-Devi
TD
Kanneganti
D000818:Animals; D020170:Caspase 1 / Q000378:metabolism; D016923:Cell Death / Q000502:physiology; D006801:Humans; D058847:Inflammasomes / Q000378:metabolism* / Q000502:physiology*; D020382:Interleukin-18 / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D000069292:Pyroptosis / Q000502:physiology
D058847:Inflammasomes; D020382:Interleukin-18; D053583:Interleukin-1beta; D020170:Caspase 1