Maternal vitamin D levels and the risk of perinatal death.
OBJECTIVE
To determine the association between maternal vitamin D levels and perinatal death.


METHODS
A retrospective cross-sectional study of all non-anomalous, singleton births (≥24 weeks) with perinatal death compared to a matched control group. Only pregnancies with a recorded vitamin D level at booking (8-19 weeks gestation) were included for analysis. Maternal vitamin D levels were categorized into normal, deficient and insufficient cohorts and variables compared between the three groups.


RESULTS
There were 31 perinatal deaths which were compared to 111 controls. Median vitamin D levels were lower in the perinatal death cohort compared to the control group (55 nmol/L versus 64 nmol/L, p = 0.43). There was no significant increase in deaths between the normal and deficient (p = 0.33) or insufficient (p = 0.09) groups.


CONCLUSIONS
Low maternal vitamin D levels at booking were not associated with an increased risk of perinatal demise.
a Mater Research Institute - University of Queensland , South Brisbane, Queensland , Australia.
India
I
McGuigan
a Mater Research Institute - University of Queensland , South Brisbane, Queensland , Australia.
Christopher
C
Flatley
a Mater Research Institute - University of Queensland , South Brisbane, Queensland , Australia.|b School of Medicine, The University of Queensland , Herston, Queensland , Australia.
Sailesh
S
Kumar
D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D066087:Perinatal Death / Q000209:etiology*; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000097:blood*
D014807:Vitamin D
Perinatal death; pregnancy; stillbirth; vitamin D