WWOX loss activates aerobic glycolysis.
Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis-a state known as "aerobic glycolysis." Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.
The Lautenberg Center for General and Tumor Immunology; Department of Immunology and Cancer Research-IMRIC; Hebrew University-Hadassah Medical School ; Jerusalem, Israel.
Muhannad
M
Abu-Remaileh
Department of Medical Oncology; Duke University Medical Center ; Durham, NC USA.
Victoria L
VL
Seewaldt
The Lautenberg Center for General and Tumor Immunology; Department of Immunology and Cancer Research-IMRIC; Hebrew University-Hadassah Medical School; Jerusalem, Israel; Human Cancer Genetics Program; Ohio State University Comprehensive Cancer Center; Columbus, OH USA.
Rami I
RI
Aqeilan
HIF1; WWOX; Warburg effect; aerobic glycolysis; breast cancer