Influence of metabolic stress on translation of p53 isoforms.
p53 and its isoforms are integral in modulating transcriptional gene expression programs and maintaining cellular homeostasis. We recently reported that glucose deprivation/caloric restriction induced translational control of p53 mRNA by scaffold/matrix attachment region binding-protein 1 (SMAR1), adding a cytoplasmic role of SMAR1 to its traditional nuclear role as a transcription factor.
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India; Present address: Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L4 and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada.
Debjit
D
Khan
National Centre for Cell Science , Ganeshkhind, Pune 411007, India.
Samit
S
Chattopadhyay
Department of Microbiology and Cell Biology, Indian Institute of Science , Bangalore 560012, India.
Saumitra
S
Das
IRES translation; SMAR1; mRNA; nutrient deprivation; p53; translational control