PLAGL1: an important player in diverse pathological processes.
The PLAGL1 gene encodes a homonymous zinc finger protein that promotes cell cycle arrest and apoptosis through multiple pathways. The protein has been implicated in metabolic, genetic, and neoplastic illnesses, but the molecular mechanisms by which the protein PLAGL1 participates in such diverse processes remains to be elucidated. In this review, we focus mainly on the molecular biology of PLAGL1 and the relevance of its abnormalities to several pathological processes.
Institute of Experimental Pathology, UNSa-CONICET, Ave. Bolivia 5150, 4400, Salta, Argentina.
Ana F
AF
Vega-Benedetti
Institute of Experimental Pathology, UNSa-CONICET, Ave. Bolivia 5150, 4400, Salta, Argentina.
Cinthia
C
Saucedo
Biochemistry, Biology and Genetics Unit, Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato SP 8, Km 0.700, 09042, Monserrato, Cagliari, Italy.
Patrizia
P
Zavattari
Biochemistry, Biology and Genetics Unit, Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato SP 8, Km 0.700, 09042, Monserrato, Cagliari, Italy.
Roberta
R
Vanni
IKERBASQUE, Basque Foundation for Science, 48011, Bilbao, Spain.|Achucarro Basque Center for Neuroscience, Bizkaia Science and Technology Park, Building 205, Zamudio, Spain.|Department of Genetics, Physic Anthropology and Animal Physiology, Faculty of Medicine and Dentistry, University of the Basque Country, Barrio Sarriena s/n, 48940, Leioa, Spain.
José L
JL
Zugaza
Institute of Experimental Pathology, UNSa-CONICET, Ave. Bolivia 5150, 4400, Salta, Argentina. lparada@unsa.edu.ar.
Luis Antonio
LA
Parada
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D030342:Genetic Diseases, Inborn / Q000235:genetics; D018392:Genomic Imprinting; D006801:Humans; D008659:Metabolic Diseases / Q000235:genetics; D051379:Mice; D009369:Neoplasms / Q000235:genetics; D051381:Rats; D014157:Transcription Factors / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D016335:Zinc Fingers
D018797:Cell Cycle Proteins; C106464:PLAGL1 protein, human; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins
Cancer; Diabetes; PLAGL1; Tumor suppressor gene