Increased serum levels of interleukin-6 and von Willenbrand Factor in early phase of acute coronary syndrome in a young and multiethnic Malaysian population.
OBJECTIVE
Interleukin-6 (IL6; proinflammatory marker), von Willebrand Factor (vWF; endothelial dysfunction marker) and P-selectin (platelet activation marker), may play important roles in defining the pathogenesis of vulnerable plaques in acute coronary syndrome (ACS). This study aims to investigate the expression and relationship of these markers in early phases of ACS in a young and multiethnic Malaysian population.


METHODS
Peripheral whole blood mRNA, and serum levels of IL6, vWF and P-selectin were measured in 22 patients with ACS, and in 28 controls with angiographically significant coronary artery disease without previous ACS events. Venous blood from ACS patients was obtained within 1 h of hospital admission.


RESULTS
No significant differences of IL6, vWF and P-selectin mRNA levels between ACS and controls were seen. ACS patients had significantly higher serum levels of IL6 and vWF (p<0.001), compared with controls. P-selectin correlated with IL6 (r=0.697, p=0.003) and vWF (r=0.497, p=0.05) at mRNA levels, indicating a possible association between these three indices of ACS pathogenesis.


CONCLUSIONS
Increased serum levels of IL6 and vWF suggest that inflammation and endothelial dysfunction may play a prominent role in the pathogenesis of the disease during the early phase of ACS.
Clinical Research Centre, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia; Department of Molecular Biology, University Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.
Wen Ni
WN
Tiong
Clinical Research Centre, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia; Department of Cardiology, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia.
Alan Yean Yip
AY
Fong
Department of Molecular Biology, University Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia.
Edmund Ui Hang
EU
Sim
Accident and Emergency Department, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia.
Hiang Chuan
HC
Chan
Department of Cardiology, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia.
Tiong Kiam
TK
Ong
Department of Cardiology, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia.
Boon Cheng
BC
Chang
Department of Cardiology, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching, Sarawak, Malaysia.
Kui Hian
KH
Sim