Atrophy of submandibular gland by the duct ligation and a blockade of SP receptor in rats.
To clarify the mechanisms underlying the submandibular gland atrophies associated with ptyalolithiasis, morphological changes were examined in the rat submandibular gland following either surgical intervention of the duct or functional blockade at substance P receptors (SPRs). Progressive acinar atrophy was observed after duct ligation or avulsion of periductal tissues. This suggested that damage to periductal tissue involving nerve fibers might contribute to ligation-associated acinar atrophy. Immunohistochemically labeled-substance P positive nerve fibers (SPFs) coursed in parallel with the main duct and were distributed around the interlobular, striated, granular and intercalated duct, and glandular acini. Strong SPR immunoreactivity was observed in the duct. Injection into the submandibular gland of a SPR antagonist induced marked acinar atrophy. The results revealed that disturbance of SPFs and SPRs might be involved in the atrophy of the submandibular gland associated with ptyalolithiasis.
Department of Oral and Maxillofacial Surgery, National Hospital Organization Nagoya Medical Center, Nagoya, Japan; Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Sumiyo
S
Hishida
Department of Functional Anatomy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University,Kanazawa, Japan.
Noriyuki
N
Ozaki
Department of Human Life Sciences, Fukushima Medical University, School of Nursing, Fukushima, Japan.
Takashi
T
Honda
Department of Oral and Maxillofacial Surgery, Nagoya Tokushukai General Hospital, Kasugai, Japan.
Toshio
T
Shigetomi
Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Minoru
M
Ueda
Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hideharu
H
Hibi
Department of Child Care Studies, School of Human Care Studies, Nagoya University of Arts and Science, Nissin, Japan.
Yasuo
Y
Sugiura
D061354:Acinar Cells; D000818:Animals; D001284:Atrophy; D008026:Ligation; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013363:Submandibular Gland
atrophy; duct ligation; nerve fiber; submandibular gland; substance P receptor