Histone deacetylases 6 increases the cyclic adenosine monophosphate level and promotes renal cyst growth.
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by abnormal enhanced cell proliferation and fluid secretion, which are triggered by increased levels of cyclic adenosine monophosphate (cAMP). Cebotaru et al. showed that a HDAC6 inhibitor reduced the cAMP level and inhibited cyst formation in Pkd1 knockout mice, which may become a new potential therapeutic agent for ADPKD. This study also raised several intriguing questions that might advance our understanding of the molecular pathogenesis of ADPKD.
Kidney Institute, Department of Nephrology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Ming
M
Wu
Kidney Institute, Department of Nephrology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address: chlmei1954@126.com.
Changlin
C
Mei
D000249:Adenosine Monophosphate; D000818:Animals; D002478:Cells, Cultured; D000242:Cyclic AMP; D003560:Cysts; D004847:Epithelial Cells / Q000187:drug effects*; D006655:Histone Deacetylases; D016891:Polycystic Kidney, Autosomal Dominant
D000249:Adenosine Monophosphate; D000242:Cyclic AMP; D006655:Histone Deacetylases