Genomic study of adolescent idiopathic scoliosis in Japan.
Adolescent idiopathic scoliosis (AIS) is a common disease. It is a multi-factorial (polygenic) disease controlled by genetic and environmental factors. Studies searching for genetic factors of AIS using linkage and association analyses have been conducted and several susceptibility genes have been reported. This paper reviews the recent progress in the genome-wide association study of AIS in Japan and comments on its future task.
Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639 Japan.
Shiro
S
Ikegawa
Adolescent idiopathic scoliosis; BNC2; GPR126; GWAS; Genetics; Japan; LBX1