Comparison of the effects of intranasal and intramuscular administrations of zolazepam-tiletamine combination on intraocular pressure in cats.
OBJECTIVE
To determine the effect of intranasal (IN) and intramuscular (IM administration of zolazepam-tiletamine (ZT) combination on intraocular pressure (IOP).


METHODS
Both eyes of 8 clinically normal cats were used.


METHODS
The animals received 10 mg/kg dose of ZT combination by IN and IM routes with a 7-day interval between treatments. IOP values were measured at baseline (T0) and at 10, 15, 20, 25, 30, and 45 min in both treatment groups.


RESULTS
There were no statistically significant differences between baseline and post-treatment IOP measurements. The IOP did not change over time regardless of administration route.


CONCLUSIONS
ZT combination did not have a significant effect on IOP in cats, when administered by IM or IN routes.
Department of Surgery, Faculty of Veterinary Medicine, Ataturk University, Erzurum, 25240, Turkey.
Latif Emrah
LE
Yanmaz
Department of Surgery, Faculty of Veterinary Medicine, Ataturk University, Erzurum, 25240, Turkey.
Elif
E
Dogan
Department of Surgery, Faculty of Veterinary Medicine, Ataturk University, Erzurum, 25240, Turkey.
Sitkican
S
Okur
Department of Surgery, Faculty of Veterinary Medicine, Ataturk University, Erzurum, 25240, Turkey.
Zafer
Z
Okumus
Department of Surgery, Faculty of Veterinary Medicine, Ataturk University, Erzurum, 25240, Turkey.
Ugur
U
Ersoz
D000281:Administration, Intranasal; D000777:Anesthetics / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D002415:Cats; D004338:Drug Combinations; D007273:Injections, Intramuscular; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D013992:Tiletamine / Q000008:administration & dosage* / Q000494:pharmacology; D015041:Zolazepam / Q000008:administration & dosage* / Q000494:pharmacology
D000777:Anesthetics; D004338:Drug Combinations; C006131:tiletamine, zolazepam drug combination; D013992:Tiletamine; D015041:Zolazepam
cat; intramuscular; intranasal; intraocular pressure; tiletamine; zolazepam