Regulation of autophagy by two products of one gene: TRPM3 and miR-204.
In clear cell renal cell carcinoma (ccRCC), oncogenic autophagy dependent on microtubule-associated protein 1 light chain 3 α and β (LC3A and LC3B) is stimulated by activity of the transient receptor potential melastatin 3 (TRPM3) channel through multiple complementary mechanisms. The Von Hippel-Lindau (VHL) tumor suppressor represses this oncogenic autophagy in a coordinated manner through the activity of miR-204, which is expressed from intron 6 of the gene encoding TRPM3. TRPM3 represents an actionable target for ccRCC treatment.
Assistant Professor, Department of Surgery, Division of Urology; University of Colorado - Denver ; Denver, CO, USA.
Nicolas G
NG
Cost
Department of Cancer Biology; University of Cincinnati College of Medicine ; Cincinnati, OH, USA.
Maria F
MF
Czyzyk-Krzeska
VHL; autophagy; microRNA; renal cancer