Toolbox for Antibiotics Discovery from Microorganisms.
Microorganisms produce a vast array of biologically active metabolites. Such compounds are applied by humans to positively influence their health and, therefore, natural products serve as drug leads for pharmaceutical and medicinal chemistry. In this minireview, tools for the discovery and the production of potential drug leads are explained. A snapshot is provided, starting from the isolation of new producer strains, across genomic mining of (meta)genomes to identify biosynthetic gene clusters corresponding to natural products, toward heterologous expression to produce potential drug leads.
Rheinische Friedrich Wilhelms Universität Bonn, Bonn, Germany.
Katja M
KM
Fisch
Rheinische Friedrich Wilhelms Universität Bonn, Bonn, Germany. till.schaeberle@uni-bonn.de.
Till F
TF
Schäberle
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D001419:Bacteria / Q000235:genetics; D001688:Biological Products / Q000302:isolation & purification*; D055808:Drug Discovery / Q000379:methods*; D005658:Fungi / Q000235:genetics; D006801:Humans; D056186:Metagenomics; D005810:Multigene Family / Q000235:genetics
D000900:Anti-Bacterial Agents; D001688:Biological Products
Antibiotics; Drug discovery; Genome mining; NRPS; PKS