TRPV1: Turning up the heat on intestinal tumorigenesis.
TRP channels are associated with the development and progression of cancer but their precise molecular roles in these processes are unclear. Recently, we showed that the transient receptor potential cation channel, subfamily V, member 1 (TRPV1) ion channel is part of a negative feedback loop downstream of epidermal growth factor receptor signaling that suppresses intestinal tumorigenesis.
Department of Medicine; UCSD; La Jolla, CA USA; Sanford-Burnham Medical Research Institute (SBMRI); NCI-Designated Cancer Center; La Jolla, CA USA.
Petrus R
PR
de Jong
Department of Medicine; UCSD ; La Jolla, CA USA.
Samuel
S
Bertin
Department of Medicine; UCSD ; La Jolla, CA USA.
Eyal
E
Raz
TRP channel; colorectal cancer; growth factor receptor signaling; ion channel; protein tyrosine phosphatase