DMET™ (Drug Metabolism Enzymes and Transporters): a pharmacogenomic platform for precision medicine.
In the era of personalized medicine, high-throughput technologies have allowed the investigation of genetic variations underlying the inter-individual variability in drug pharmacokinetics/pharmacodynamics. Several studies have recently moved from a candidate gene-based pharmacogenetic approach to genome-wide pharmacogenomic analyses to identify biomarkers for selection of patient-tailored therapies. In this aim, the identification of genetic variants affecting the individual drug metabolism is relevant for the definition of more active and less toxic treatments. This review focuses on the potentiality, reliability and limitations of the DMET™ (Drug Metabolism Enzymes and Transporters) Plus as pharmacogenomic drug metabolism multi-gene panel platform for selecting biomarkers in the final aim to optimize drugs use and characterize the individual genetic background.
ISN-CNR, Roccelletta di Borgia, Catanzaro, Italy.
Mariamena
M
Arbitrio
Department of Experimental and Clinical Medicine, Medical Oncology Unit, Mater Domini Hospital, Magna Graecia University, Salvatore Venuta University Campus, Catanzaro, Italy.
Maria Teresa
MT
Di Martino
Department of Experimental and Clinical Medicine, Medical Oncology Unit, Mater Domini Hospital, Magna Graecia University, Salvatore Venuta University Campus, Catanzaro, Italy.
Francesca
F
Scionti
Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.
Giuseppe
G
Agapito
Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.
Pietro Hiram
PH
Guzzi
Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.|ICAR-CNR, Cosenza, Italy.
Mario
M
Cannataro
Department of Experimental and Clinical Medicine, Medical Oncology Unit, Mater Domini Hospital, Magna Graecia University, Salvatore Venuta University Campus, Catanzaro, Italy.
Pierfrancesco
P
Tassone
Department of Experimental and Clinical Medicine, Medical Oncology Unit, Mater Domini Hospital, Magna Graecia University, Salvatore Venuta University Campus, Catanzaro, Italy.
Pierosandro
P
Tagliaferri
D005819:Genetic Markers; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics; D010597:Pharmacogenetics / Q000379:methods*; D057285:Precision Medicine / Q000379:methods*
D005819:Genetic Markers; D026901:Membrane Transport Proteins
ADME genes; DMET™; biomarkers; pharmacogenomics; single nucleotide polymorphism