Iron, hormesis, and protection in acute kidney injury.
Iron is critical for cellular, organismal, and possibly universal existence. Use of iron complexes to treat human diseases is ancient and is described in detail in Ayurveda/Siddha systems of medicine. Old aphorisms from Siddha medicine ("Alavukku Minjinal Amirdhamum Nanjagum," an elixir turns poisonous when taken in excess) and Paracelsus ("Die Dosis macht das Gift," the dose makes the poison) are of practical relevance in understanding the role of this ancient metal in acute kidney injury.
Department of Nephrology, University of Virginia Health System, Charlottesville, VA, USA. Electronic address: swami@virginia.edu.
Sundararaman
S
Swaminathan
D058186:Acute Kidney Injury; D059165:Hormesis; D006801:Humans; D007501:Iron
D007501:Iron