Photoredox-Catalyzed Hydroxymethylation of Heteroaromatic Bases.
We report the development of a method for room-temperature C-H hydroxymethylation of heteroarenes. A key enabling advance in this work was achieved by implementing visible light photoredox catalysis that proved to be applicable to many classes of heteroarenes and tolerant of diverse functional groups found in druglike molecules.
Department of Medicinal Chemistry, Merck Research Laboratories , P.O. Box 2000, Rahway, New Jersey 07065, United States.
Chelsea A
CA
Huff
Process Research & Development, Merck Research Laboratories , P.O. Box 2000, Rahway, New Jersey 07065, United States.
Ryan D
RD
Cohen
Department of Medicinal Chemistry, Merck Research Laboratories , P.O. Box 2000, Rahway, New Jersey 07065, United States.
Kevin D
KD
Dykstra
Department of Medicinal Chemistry, Merck Research Laboratories , P.O. Box 2000, Rahway, New Jersey 07065, United States.
Eric
E
Streckfuss
Process Research & Development, Merck Research Laboratories , P.O. Box 2000, Rahway, New Jersey 07065, United States.
Daniel A
DA
DiRocco
Department of Medicinal Chemistry, Merck Research Laboratories , P.O. Box 2000, Rahway, New Jersey 07065, United States.
Shane W
SW
Krska