ATM: An unexpected tumor-promoting factor in HER2-expressing tumors.
ATM kinase is a gatekeeper of genome stability. However, its role in several other signaling pathways suggests that it might not always act as a tumor suppressor. Here, we discuss recent data that unveil a function of ATM as a tumor promoter in HER2-positive breast cancer.
Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia , Rome, Italy.
Venturina
V
Stagni
Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy; Department of Biology, University of Rome "Tor Vergata", Rome, Italy.
Veronica
V
Oropallo
Laboratory of Cell Signaling, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy; Department of Biology, University of Rome "Tor Vergata", Rome, Italy.
Daniela
D
Barilà
ATM kinase; HER2 receptor tyrosine kinase; HSP90; breast cancer; tumor suppressor genes and oncogenes