Targeting translesion synthesis to facilitate the eradication of ovarian cancer stem cells by platinum-based therapy.
Understanding the mechanisms by which cancer stem cells (CSCs) survive chemotherapy is essential for the development of new therapies. Recently, we demonstrated that ovarian CSCs survive cisplatin treatment through enhanced expression of DNA polymerase η (Pol η). Identification of micro RNA-93 (miR-93) as the regulator of Pol η provides a novel target to improve the outcome of platinum-based therapy.
Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Amit Kumar
AK
Srivastava
Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Qi-En
QE
Wang
Cancer stem cell; DNA repair; cisplatin resistance; translesion synthesis