Myocardial recovery with mechanical circulatory support.
Mechanical circulatory support (MCS) is instituted in patients with advanced heart failure, some of who may experience sufficient recovery in cardiac function to allow withdrawal of mechanical support. The incidence of left ventricular recovery with MCS is unclear as reported series in the literature demonstrate widely divergent rates. A number of clinical parameters (including echocardiographic, haemodynamic and physiological) are used to indicate likely left ventricular recovery during pump speed reduction but no internationally agreed definition exists. Withdrawal of MCS is not without risk and so robust clinical and biochemical definitions are important to minimize patient morbidity and mortality. Here we review our current understanding of left ventricular recovery with MCS.
The Transplant Unit, University Hospital of South Manchester, Southmoor Road, Manchester, M23 9LT, UK. pchaggar@doctors.org.uk.|The Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, UK. pchaggar@doctors.org.uk.
Parminder S
PS
Chaggar
The Transplant Unit, University Hospital of South Manchester, Southmoor Road, Manchester, M23 9LT, UK.
Simon G
SG
Williams
The Transplant Unit, University Hospital of South Manchester, Southmoor Road, Manchester, M23 9LT, UK.
Nizar
N
Yonan
The Transplant Unit, University Hospital of South Manchester, Southmoor Road, Manchester, M23 9LT, UK.|The Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, UK.
James
J
Fildes
The Transplant Unit, University Hospital of South Manchester, Southmoor Road, Manchester, M23 9LT, UK.
Rajamiyer
R
Venkateswaran
The Transplant Unit, University Hospital of South Manchester, Southmoor Road, Manchester, M23 9LT, UK.
Steven M
SM
Shaw
D006333:Heart Failure / Q000503:physiopathology* / Q000601:surgery*; D006352:Heart Ventricles / Q000503:physiopathology*; D006353:Heart-Assist Devices; D006801:Humans; D032383:Myocytes, Cardiac / Q000502:physiology; D020127:Recovery of Function; D018487:Ventricular Dysfunction, Left / Q000601:surgery*
Heart failure; Left ventricular assist device; Mechanical circulatory support; Myocardial recovery