Cannabinoid Poisoning by Hemp Seed Oil in a Child.
We report a case of mild cannabinoid poisoning in a preschool child, after 3-week ingestion of hemp seed oil prescribed by his pediatrician to strengthen his immune system. The patient presented neurological symptoms that disappeared after intravenous hydration. A possible mild withdrawal syndrome was reported after discharge. The main metabolite of Δ-tetrahydrocannabinol was detected in urine, and very low concentration of Δ-tetrahydrocannabinol was detected in the ingested product. This is, as far as we know, the first report of cannabinoid poisoning after medical prescription of hemp seed oil in a preschool child.
From the *University of Trieste, Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste; †Department of Pediatrics and Pediatric Hematology, S. Camillo-Forlanini Hospital; ‡Legal Medicine Department, Public Health Institute, Catholic University of the Sacred Heart; and §Department of Biomedicine and Prevention, Genetics Unit, University of Rome Tor Vergata, Rome, Italy.
Matteo
M
Chinello
Salvatore
S
Scommegna
Alison
A
Shardlow
Francesca
F
Mazzoli
Nadia
N
De Giovanni
Nadia
N
Fucci
Paola
P
Borgiani
Cinzia
C
Ciccacci
Anna
A
Locasciulli
Mauro
M
Calvani
D002186:Cannabinoids / Q000506:poisoning*; D002188:Cannabis / Q000009:adverse effects*; D002675:Child, Preschool; D065729:Cytochrome P-450 CYP2C9 / Q000378:metabolism; D051544:Cytochrome P-450 CYP3A / Q000378:metabolism; D013759:Dronabinol / Q000378:metabolism / Q000652:urine*; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D008297:Male; D010938:Plant Oils / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011041:Poisoning / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D012639:Seeds / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis* / Q000209:etiology; D016896:Treatment Outcome
D002186:Cannabinoids; D010938:Plant Oils; D013759:Dronabinol; D065729:Cytochrome P-450 CYP2C9; D051544:Cytochrome P-450 CYP3A