Involvement of USP24 in the DNA damage response.
Deubiquitination has emerged as an important mechanism of regulating DNA repair pathways. We recently reported that USP24 is a novel p53 deubiquitinase that stabilizes p53 upon DNA damage. USP24 is upregulated by DNA damaging agents and plays an important role in maintaining genome stability.
Department of Biochemistry and Molecular Biology; University of Miami Miller School of Medicine ; Miami, FL USA.
Ling
L
Zhang
Department of Biochemistry and Molecular Biology; University of Miami Miller School of Medicine ; Miami, FL USA.
Feng
F
Gong
DNA damage response; USP24; deubiquitinase; deubiquitination; p53