Chelation-Assisted Copper-Mediated Direct Acetylamination of 2-Arylpyridine C-H Bonds with Cyanate Salts.
In this study, the coupling of 2-phenylpyridine derivatives and potassium cyanate through C-H bond functionalization in the presence of a copper salt is developed for the first time. By this protocol, various heteroarylated acetanilide derivatives are synthesized in good yields. 2-Phenylpyridines containing electron-donating and -withdrawing groups appear to be well-tolerated by this transformation.
School of Chemistry, College of Science, University of Tehran , Tehran 1417614411, Iran.
Ebrahim
E
Kianmehr
School of Chemistry, College of Science, University of Tehran , Tehran 1417614411, Iran.
Yousef
Y
Amiri Lomedasht
School of Chemistry, College of Science, University of Tehran , Tehran 1417614411, Iran.
Nasser
N
Faghih
H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi , Karachi 75270, Pakistan.
Khalid Mohammed
KM
Khan