Metabolic Effects of Obesity and Its Interaction with Endocrine Diseases.
Obesity in pet dogs and cats is a significant problem in developed countries, and seems to be increasing in prevalence. Excess body fat has adverse metabolic consequences, including insulin resistance, altered adipokine secretion, changes in metabolic rate, abnormal lipid metabolism, and fat accumulation in visceral organs. Obese cats are predisposed to endocrine and metabolic disorders such as diabetes and hepatic lipidosis. A connection likely also exists between obesity and diabetes mellitus in dogs. No system has been developed to identify obese pets at greatest risk for development of obesity-associated metabolic diseases, and further study in this area is needed.
Department of Internal Medicine, The Animal Medical Center, 510 East 62nd Street, New York, NY 10065, USA. Electronic address: melissa.clark@amcny.org.
Melissa
M
Clark
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, Urbana-Champaign, IL 61802, USA.
Margarethe
M
Hoenig
D000273:Adipose Tissue; D000818:Animals; D001823:Body Composition; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D009765:Obesity / Q000150:complications / Q000662:veterinary*
Adipocytokines; Canine; Diabetes; Dyslipidemia; Feline; Hepatic lipidosis; Insulin resistance; Obesity