A cancerous web: signaling, metabolism, and the epigenome.
Histone acetylation is sensitive to the availability of acetyl-CoA. However, the extent to which metabolic alterations in cancer cells impact tumor histone acetylation has been unclear. Here, we discuss our recent findings that oncogenic AKT1 activation regulates histone acetylation levels in tumors through regulation of acetyl-CoA metabolism.
Department of Cancer Biology and Abramson Family Cancer Research Institute; University of Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Joyce V
JV
Lee
Department of Cancer Biology and Abramson Family Cancer Research Institute; University of Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Supriya
S
Shah
Department of Cancer Biology and Abramson Family Cancer Research Institute; University of Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Alessandro
A
Carrer
Department of Cancer Biology and Abramson Family Cancer Research Institute; University of Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
Kathryn E
KE
Wellen
AKT1; ATP-citrate lyase; acetyl-CoA; cancer metabolism; histone acetylation