Quercetin protects rat skeletal muscle from ischemia reperfusion injury.
In this study, we investigated the potential beneficial effects of quercetin on skeletal muscle ischemia reperfusion injury. Twenty-four Sprague-Dawley type rats were randomly divided into four groups. In the sham group, only gastrocnemius muscle were removed and given no quercetin. In ischemia group, all the femoral artery, vein and collaterals were occluded in the left hindlimb by applying tourniquate under general anaesthesia for three hours but reperfusion was not done. In the Quercetin + Ischemia reperfusion group, quercetin (200 mg kg-1dose orally) was given during one-week reoperation and later ischemia reperfusion model was done. Finally, gastrocnemius muscle samples were removed to measure biochemical parameters. The biomarkers, MDA levels, SOD, CAT and GPx activities, were evaluated related to skeletal muscle ischemia reperfusion injury. MDA levels reduced and SOD, CAT and GPx activities increased significantly in Quercetin + Ischemia reperfusion group. Results clearly showed that Quercetin have a protective role against oxidative damage induced by ischemia reperfusion in rats.
a Department of Nutrition and Dietetics , Health School, Agri İbrahim Cecen University , Agri , Turkey.
Fazile Nur
FN
Ekinci Akdemir
b Faculty of Sciences , Department of Chemistry, Atatürk University , Erzurum , Turkey.|c Department of Zoology , College of Science, King Saud University , Riyadh , Saudi Arabia.
İlhami
İ
Gülçin
d Department of Pharmacology , Faculty of Pharmacy, Agri İbrahim Cecen University , Agri , Turkey , and.
Berna
B
Karagöz
e Physical Education and Sports, Bartın University , Bartin , Turkey.
Recep
R
Soslu
D000818:Animals; D004195:Disease Models, Animal; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*
D011794:Quercetin
Antioxidant enzymes; ischemia reperfusion; quercetin; skeletal muscle