UCP2 induces metabolic reprogramming to inhibit proliferation of cancer cells.
Invalidation of uncoupling protein 2 (Ucp2) increases glucose utilization and proliferation in normal cells. We recently reported that cancer cells that overexpress UCP2 become less tumorigenic while switching their metabolism from glycolysis to oxidative phosphorylation. UCP2 appears to be a key regulator of cellular metabolism with a relevant function against tumorigenesis.
Inserm, U1016; Institut Cochin; Paris, 75014, France; CNRS; UMR 8104; Paris, France; Université Paris Descartes; Sorbonne Paris Cité; Paris, France; These authors contributed equally to this article.
Pauline
P
Esteves
CRCNA - UMR 892 INSERM - 6299 CNRS; Nantes, France; Faculté de Médecine; Université de Nantes; Nantes, France; These authors contributed equally to this article.
Claire
C
Pecqueur
Inserm, U1016; Institut Cochin; Paris, 75014, France; CNRS; UMR 8104; Paris, France; Université Paris Descartes; Sorbonne Paris Cité; Paris, France.
Marie-Clotilde
MC
Alves-Guerra
cancer; metabolism reprogramming; mitochondria; proliferation; uncoupling protein 2