Ferroptosis: A missing puzzle piece in the p53 blueprint?
Recent evidence indicates that canonical functions of p53 (i.e., apoptosis and growth arrest) are dispensable for p53-mediated tumor suppression. We have uncovered a novel function of p53 that contributes to tumor suppression through regulation of cystine metabolism, reactive oxygen species responses, and ferroptosis. The p53-mediated ferroptotic response via SLC7A11 denotes an extra layer of defense against tumorigenesis in conjunction with other p53 functions.
Institute for Cancer Genetics and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University , New York, NY, USA.
Shang-Jui
SJ
Wang
Institute for Cancer Genetics and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University , New York, NY, USA.
Yang
Y
Ou
Institute for Cancer Genetics and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University , New York, NY, USA.
Le
L
Jiang
Institute for Cancer Genetics and Department of Pathology and Cell Biology, College of Physicians & Surgeons, Columbia University , New York, NY, USA.
Wei
W
Gu
Ferroptosis; metabolism; non-apoptotic cell death; p53; tumor suppression