Aberrantly expressed microRNAs in the context of bladder tumorigenesis.
MicroRNAs (miRNAs), small noncoding RNAs 19-22 nucleotides in length, play a major role in negative regulation of gene expression at the posttranscriptional level. Several miRNAs act as tumor suppressors or oncogenes that control cell differentiation, proliferation, apoptosis, or angiogenesis during tumorigenesis. To date, 19 research groups have published large-scale expression profiles that identified 261 miRNAs differentially expressed in bladder cancer, of which 76 were confirmed to have consistent expression patterns by two or more groups. These consistently expressed miRNAs participated in regulation of multiple biological processes and factors, including axon guidance, cancer-associated proteoglycans, and the ErbB and transforming growth factorbeta signaling pathways. Because miRNAs can be released from cancer cells into urine via secreted particles, we propose that miRNAs differentially expressed between tissue and urine could serve as predictors of bladder cancer, and could thus be exploited for noninvasive diagnosis.
Theragen Etex Bio Institute, Suwon, Korea.
Jong-Young
JY
Lee
Theragen Etex Bio Institute, Suwon, Korea.
Dong-Sung
DS
Ryu
Department of Urology, Chungbuk National University College of Medicine, Cheongju, Korea.
Wun-Jae
WJ
Kim
Theragen Etex Bio Institute, Suwon, Korea.
Seong-Jin
SJ
Kim
D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D063646:Carcinogenesis / Q000235:genetics*; D020869:Gene Expression Profiling / Q000379:methods; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D012334:RNA, Neoplasm / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000235:genetics*
D014408:Biomarkers, Tumor; D035683:MicroRNAs; D012334:RNA, Neoplasm
MicroRNAs; Neoplasms; Urinary bladder neoplasms