Disseminated intravascular coagulation - new pathophysiological concepts and impact on management.
BACKGROUND
Disseminated intravascular coagulation (DIC) is an intermediary mechanism of disease which develops secondary to many causes including sepsis, trauma and malignancies. This review attempts to summarise the new pathophysiological developments and the impact they have on the current and future management of DIC.


METHODS
Several publications detailing the pathophysiology of DIC and the clinical management were identified using a pubmed search. Expert commentary: In recent years, on the initiatives of the international society of thrombosis and haemostasis, important advances have been made on the diagnostic aspect of DIC. In addition, several researchers have focused on the pathophysiology of the condition which is likely to provide better diagnostic markers and targeted therapy. However, some confusion still exists in the definition and management of DIC since various specialists understands the mechanisms involved in DIC from different perspectives.
a Department of Haematology , Central Manchester University Hospitals NHS Foundation Trust , Manchester , UK.
Jecko
J
Thachil
D000925:Anticoagulants / Q000627:therapeutic use; D015415:Biomarkers; D001773:Blood Cells / Q000276:immunology / Q000378:metabolism; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D015897:Comorbidity; D003165:Complement System Proteins / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D019468:Disease Management; D004198:Disease Susceptibility; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy*; D004730:Endothelium, Vascular / Q000276:immunology / Q000378:metabolism; D006801:Humans
D000925:Anticoagulants; D015415:Biomarkers; D016207:Cytokines; D003165:Complement System Proteins
Platelets; anticoagulation; coagulation; disseminated intravascular coagulation; histones