Paracrine WNT5A signaling in healthy and neoplastic mammary tissue.
Paracrine signaling between mammary epithelial cells has long been appreciated. Recently, we found that Wnt5a, a novel noncanonical Wnt ligand of luminal origin, counteracts canonical Wnt signaling in basal mammary epithelial cells through a paracrine pathway, inhibits the expansion of Erbb2-induced tumor-initiating cells, and suppresses tumor incidence and metastasis.
Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA; Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, USA.
David
D
Kusner
Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA; Medical Science Training Program, Carver College of Medicine, University of Iowa, Iowa City, USA; Molecular and Cellular Biology Program, Carver College of Medicine, University of Iowa, Iowa City, USA.
Nicholas
N
Borcherding
Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, USA; Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, USA; Medical Science Training Program, Carver College of Medicine, University of Iowa, Iowa City, USA; Molecular and Cellular Biology Program, Carver College of Medicine, University of Iowa, Iowa City, USA; Immunology Program, Carver College of Medicine, University of Iowa, Iowa City, USA.
Weizhou
W
Zhang
Breast cancer; Noncanonical WNT; WNT5A signaling; mammary development