Correlations between geriatric nutritional risk index and peripheral artery disease in elderly coronary artery disease patients.
OBJECTIVE
Malnutrition is associated with the development of atherosclerosis and an increased risk of cardiovascular mortality in elderly patients. The present study aimed to investigate the association between the Geriatric Nutritional Risk Index (GNRI), a simple nutritional assessment tool, and the prevalence of peripheral artery disease (PAD) in elderly coronary artery disease patients.


METHODS
We evaluated 228 elderly coronary artery disease patients (mean age 74.0 ± 5.7 years). Ankle-brachial index (ABI) measurements were routinely carried out to investigate the prevalence of lower extremity PAD. Patients showing ABI <0.9 were defined as having PAD.


RESULTS
Based on our findings, 20.6% of the study patients had PAD. The median GNRI values were significantly lower in patients with PAD than those in patients without PAD (93.8 vs 100.0, P < 0.001). Even after multivariate adjustment, GNRI values were independently associated with PAD (odds ratio 0.94; 95% confidence interval 0.89-0.99; P = 0.024). Furthermore, patients with low GNRI and high C-reactive protein levels had a 5.5-fold higher risk of having PAD than those with high GNRI and low C-reactive protein levels.


CONCLUSIONS
GNRI values showed a strong relationship with PAD in elderly coronary artery disease patients. These data reinforce the utility of GNRI as a screening tool in clinical practice. Geriatr Gerontol Int 2017; 17: 1057-1062.
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.|Department of Neurology, Yagoto Hospital, Nagoya, Japan.
Toshiki
T
Kawamiya
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Susumu
S
Suzuki
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hideki
H
Ishii
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kenshi
K
Hirayama
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kazuhiro
K
Harada
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yohei
Y
Shibata
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yosuke
Y
Tatami
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shingo
S
Harata
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kazuhiro
K
Kawashima
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ayako
A
Kunimura
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yohei
Y
Takayama
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yusaku
Y
Shimbo
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Naohiro
N
Osugi
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Dai
D
Yamamoto
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tomoyuki
T
Ota
Department of Neurology, Yagoto Hospital, Nagoya, Japan.
Chikao
C
Kono
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Toyoaki
T
Murohara
D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D002097:C-Reactive Protein / Q000502:physiology; D015331:Cohort Studies; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D015577:Geriatric Assessment / Q000379:methods; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D015596:Nutrition Assessment; D009752:Nutritional Status / Q000502:physiology; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index
D002097:C-Reactive Protein
coronary artery disease; elderly; inflammation; malnutrition; peripheral artery disease