Redefining the roles of apoptotic factors in carcinogenesis.
In a recent study we reported that mammalian cells exposed to stress such as ionizing radiation can survive with activation of caspase-3 or caspase-7. We found that sublethal activation of the executioner caspases promotes chemical- and radiation-induced genetic instability and carcinogenesis, in contrast to their perceived roles as tumor suppressors.
Department of Dermatology, Duke University Medical Center , Durham, NC, USA.
Xinjian
X
Liu
Department of General Surgery, Daping Hospital, Third Military Medical University , Chongqing, China.
Yujun
Y
He
Cancer Center, First People's Hospital, Shanghai Jiaotong University, School of Medicine , Shanghai, China.
Fang
F
Li
Department of Environmental and Radiological Health Sciences, Colorado State University , Fort Collins, CO, USA.
Qian
Q
Huang
Department of Pharmacology, Duke University Medical Center , Durham, NC, USA.
Takamitsu A
TA
Kato
Department of Dermatology, Duke University Medical Center , Durham, NC, USA.
Russell P
RP
Hall
Department of Dermatology, Duke University Medical Center, Durham, NC, USA; Department of Pharmacology, Duke University Medical Center, Durham, NC, USA; Department of Cancer Biology, Duke University Medical Center, Durham, NC, USA.
Chuan-Yuan
CY
Li
Caspase-3; carcinogenesis; endonuclease G; genetic instability