Polymorphic CAG Repeat Numbers in the Androgen Receptor Gene of Female Pattern Hair Loss in a Han Chinese Population.
OBJECTIVE
To investigate the association of CAG repeat numbers in the androgen receptor (AR) gene with female pattern hair loss (FPHL) in a Chinese population.


METHODS
A total of 200 Han Chinese patients with FPHL (142 Ludwig II and 58 Ludwig III cases) and 200 healthy controls were enrolled in this study. The polymorphism of CAG repeat numbers was analyzed by the fluorescent amplified fragment length polymorphism technique.


RESULTS
The CAG biallelic mean length was 23.73 ± 2.04 repeats in Han Chinese FPHL patients and 23.90 ± 2.13 repeats in healthy controls, without any significant difference between the two groups (p = 0.481). In addition, neither the shorter nor the longer CAG repeat numbers were significantly different between FPHL and control subjects (p = 0.726, p = 0.383).


CONCLUSIONS
The polymorphism of CAG repeat numbers of the AR gene may not be the genetic marker of FPHL in a Chinese population.
Department of Dermatology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Wenlong
W
Rui
Youyu
Y
Sheng
Ruiming
R
Hu
Ying
Y
Miao
Yumei
Y
Han
Sisi
S
Qi
Feng
F
Xu
Jinhua
J
Xu
Qinping
Q
Yang
D000328:Adult; D000505:Alopecia / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D054458:Amplified Fragment Length Polymorphism Analysis; D002681:China / Q000453:epidemiology; D041321:Chromosomes, Human, X / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D005260:Female; D006801:Humans; D015994:Incidence; D018598:Minisatellite Repeats; D011110:Polymorphism, Genetic; D011944:Receptors, Androgen / Q000235:genetics* / Q000378:metabolism
C410798:AR protein, human; D017931:DNA Primers; D011944:Receptors, Androgen