FOXC1-induced Gli2 activation: A non-canonical pathway contributing to stemness and anti-Hedgehog resistance in basal-like breast cancer.
The Forkhead box C1 (FOXC1) transcriptional factor is a critical biomarker for basal-like breast cancer (BLBC). We recently reported that FOXC1 promotes cancer stem cell properties in BLBC by activating Smoothened (SMO)-independent Hedgehog (Hh) signaling, suggesting a FOXC1-mediated mechanism for BLBC cell function and anti-Hh therapy resistance.
Department of Surgery, Samuel Oschin Cancer Institute, Cedars-Sinai Medical Center , Los Angeles, CA, USA.
Bingchen
B
Han
Department of Surgery, Samuel Oschin Cancer Institute, Cedars-Sinai Medical Center , Los Angeles, CA, USA.
Ying
Y
Qu
Department of Surgery, Samuel Oschin Cancer Institute, Cedars-Sinai Medical Center , Los Angeles, CA, USA.
Yi
Y
Yu-Rice
Department of Surgery, Samuel Oschin Cancer Institute, Cedars-Sinai Medical Center , Los Angeles, CA, USA.
Jeffrey
J
Johnson
Department of Surgery, Samuel Oschin Cancer Institute, Cedars-Sinai Medical Center , Los Angeles, CA, USA.
Xiaojiang
X
Cui
Basal-like breast cancer; FOXC1; GLI2; Hedgehog; Smoothened; cancer stem cells