[Effect of a lithium-doped calcium phosphate cement in promoting tibial bone defect repair in rats].
OBJECTIVE
To evaluate the effects a lithium chloride-doped calcium phosphate cement (Li/CPC) on promoting tibial defect repair in rats.


METHODS
Twenty 6-month-old female SD rats randomized into Li/CPC (n=10) and CPC control (n=10) groups. Surgery was performed to create bone defects at the bilateral tibia, which were filled with either of the cement. Five rats from each group were sacrificed at 1 and 2 months after the surgery for micro-CT examination and HE staining of the tibia.


RESULTS
Micro-CT showed better repair of bone defects in Li/CPC group, which had a significantly higher new bone volume fraction (BV/TV) and a lower trabecular separation/spacing (Tb.Sp) than the control group (P<0.05). HE staining showed an earlier appearance of fiber and osteoid callus in Li/CPC group than CPC control group. The number and quality of bone healing was significantly higher in Li/CPC group than in CPC group.


CONCLUSIONS
Li/CPC possessed better osteoinductivity and can significantly promote bone defect repair in rats.
Department of Orthopedics, Fourth Affiliated Hospital of Guangxi Medical University/Liuzhou Worker's Hospital, Liuzhou 545005, China. E-mail: gukelili001@163.com.
Li
L
Li
Yong-Bao
YB
Qin
Gang
G
Ma
Bing
B
Li
D000818:Animals; D001843:Bone Cements / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D005260:Female; D008094:Lithium / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013977:Tibia / Q000473:pathology*
D001843:Bone Cements; D002130:Calcium Phosphates; D008094:Lithium