Cytomegalovirus antibody and vascular pathology in renal transplant recipients.
Cytomegalovirus (CMV) has been linked with vascular pathology and is a common complication of renal transplantation. We addressed whether CMV seropositivity influences vascular pathology several years after transplant. Levels of CMV antibody increased with age, were higher in transplant recipients than healthy controls (P < 0.001), and correlated with vascular endothelial function measured by flow mediated-dilation of the brachial artery (FMD). However, the optimal general linear model predicting FMD included CMV seropositivity as a marginal effect (P = 0.068), with age (P = 0.013), gender (P < 0.0001), and transplantation (P < 0.0001). Other measures of the burden of CMV are being tested as CMV prophylaxis is feasible as an approach to reduce vascular disease. J. Med. Virol. 89:177-181, 2017. © 2016 Wiley Periodicals, Inc.
School of Biomedical Science, Curtin University, Bentley, Australia. patricia.price@curtin.edu.au.|Curtin Health Innovation Research Institute, Curtin University, Bentley, Australia. patricia.price@curtin.edu.au.|School of Medicine and Pharmacology, University of Western Australia, Nedlands, Australia. patricia.price@curtin.edu.au.
Patricia
P
Price
School of Biomedical Science, Curtin University, Bentley, Australia.|Curtin Health Innovation Research Institute, Curtin University, Bentley, Australia.|Department of Microbiology, Royal Perth Hospital, Perth, Australia.
Silvia
S
Lee
School of Biomedical Science, Curtin University, Bentley, Australia.|Curtin Health Innovation Research Institute, Curtin University, Bentley, Australia.
Jacquita
J
Affandi
School of Pharmacy, Curtin University, Bentley, Australia.
Richard
R
Parsons
Sport Science, Exercise and Health, University of Western Australia, Nedlands, Australia.
Louise H
LH
Naylor
School of Medicine and Pharmacology, University of Western Australia, Nedlands, Australia.
Gerald F
GF
Watts
School of Medicine and Pharmacology, University of Western Australia, Nedlands, Australia.|Renal Unit, Fiona Stanley hospital, Murdoch, Australia.
Ashley
A
Irish
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D003586:Cytomegalovirus Infections / Q000150:complications*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D066027:Transplant Recipients; D014652:Vascular Diseases / Q000473:pathology*; D014664:Vasodilation; D055815:Young Adult
D000914:Antibodies, Viral
aging; cardiovascular disease; cytomegalovirus; renal transplantation