Angiographic Findings after Supplementation with Heracleum persicum Extract: Results of a Randomized Controlled Trial.
BACKGROUND
Heracleum persicum is a common dietary spice with several traditional medicinal properties important for cardiovascular health including antioxidant, hypolipidemic, and anti-inflammatory effects. This study explored the effects of supplementation with H. persicum fruit on the angiographic findings of patients with minimal coronary artery disease (CAD).


METHODS
Subjects who were diagnosed with <50% stenosis in any of their coronary arteries by angiography were selected for this trial and randomly assigned to H. persicum hydroalcoholic fruit extract (n = 15; 300 mg/day) or placebo (n = 12) for 6 months. At the end of the trial, participants underwent a second coronary angiography in order to evaluate the progression of their disease.


RESULTS
Posttrial angiography did not reveal any improvement in the number of stenosed vessels after consumption of H. persicum extract versus placebo (P > 0.05). Similarly, there was no significant difference between the study groups in terms of disease progression and chest pain score (P > 0.05).


CONCLUSIONS
The present results do not support any clinically significant benefit of supplementation with H. persicum extract on the angiographic findings of in patients with minimal CAD.
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Yunes
Y
Panahi
Department of Cardiology, Cardiovascular Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Bahram
B
Pishgoo
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
Amirhossein
A
Sahebkar
Angiography; Heracleum persicum; herbal pharmacotherapy; ischaemic heart disease; randomized controlled trial