Biogenesis and Functions of Exosomes and Extracellular Vesicles.
Research on extracellular vesicles (EVs) is a new and emerging field that is rapidly growing. Many features of these structures still need to be described and discovered. This concerns their biogenesis, their release and cellular entrance mechanisms, as well as their functions, particularly in vivo. Hence our knowledge on EV is constantly evolving and sometimes changing. In our review we summarize the most important facts of our current knowledge about extracellular vesicles and described some of the assumed functions in the context of cancer and HIV infection.
Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg, Hartmannstr. 14, 91054, Erlangen, Germany.
Florian
F
Dreyer
Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg, Hartmannstr. 14, 91054, Erlangen, Germany. andreas.baur@uk-erlangen.de.
Andreas
A
Baur
D055354:Exosomes / Q000235:genetics* / Q000378:metabolism; D000067128:Extracellular Vesicles / Q000235:genetics* / Q000378:metabolism; D015658:HIV Infections / Q000235:genetics* / Q000473:pathology; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology
Biomarker; ESCRT; Exosomes; Extracellular vesicles; HIV