Eat this, not that! How selective autophagy helps cancer cells survive.
Autophagy degrades the cellular proteome to promote survival, but the underlying mechanism and substrates of consequence are poorly understood. We found that autophagy selectively remodels the proteome in cancer cells by eliminating proinflammatory signaling proteins. Autophagy ablation causes aberrant accumulation of these proteins that primes cancer cells for interferon-dependent cell death, explaining how autophagy suppresses inflammation and promotes tumor maintenance.
Rutgers Cancer Institute of New Jersey ; New Brunswick, NJ USA.
Robin
R
Mathew
Rutgers Cancer Institute of New Jersey; New Brunswick, NJ USA; Department of Molecular Biology and Biochemistry; Rutgers University; Piscataway, NJ USA.
Eileen
E
White
autophagy; biomarkers; immuno-oncology; innate immunity; interferon