Of mice and women: do sex-dependent responses to ischemia-reperfusion injury in rodents have implications for delayed graft function in humans?
In rodent models, female sex has been shown to be protective against ischemia-reperfusion injury. A recent publication suggests that this sex-dependent response to injury may have clinical implications for delayed graft function after kidney transplantation.
Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: christina.wyatt@mssm.edu.
Christina M
CM
Wyatt
Renal and Transplantation Service, Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
P Toby
PT
Coates
Division of Nephrology, Department of Medicine, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.
W Brian
WB
Reeves
D000818:Animals; D051799:Delayed Graft Function; D005260:Female; D006801:Humans; D007668:Kidney; D016030:Kidney Transplantation; D051379:Mice; D015427:Reperfusion Injury