Selenoprotein P in colitis-associated carcinoma.
Patients with inflammatory bowel disease are often deficient in micronutrients such as selenium and have an increased risk of colon cancer. We tested whether the selenium transport protein, selenoprotein P, could modify colitis-associated cancer. Our results indicate that global SEPP1 haploinsufficiency augments tumorigenesis and mediates oxidative damage in the intestine.
Department of Medicine, Division of Gastroenterology, Vanderbilt University, Nashville, TN, USA; Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA; Vanderbilt Ingram Cancer Center, Nashville, TN, USA.
Sarah P
SP
Short
Department of Medicine, Division of Gastroenterology, Vanderbilt University, Nashville, TN, USA; Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA; Vanderbilt Ingram Cancer Center, Nashville, TN, USA.
Caitlyn
C
Whitten-Barrett
Department of Medicine, Division of Gastroenterology, Vanderbilt University, Nashville, TN, USA; Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA; Vanderbilt Ingram Cancer Center, Nashville, TN, USA; Veterans Affairs Tennessee Valley Health Care System, Nashville, TN, USA.
Christopher S
CS
Williams
Cancer; IBD; SEPP1; selenoprotein P; ulcerative colitis