WntD and Diedel: Two immunomodulatory cytokines in Drosophila immunity.
Remarkable progress has been made on the understanding of the basic mechanisms of innate immunity in flies, from sensing infection to production of effector molecules. However, how the immune response is orchestrated at the level of the organism remains poorly understood. While cytokines activating immune responses, such as Spaetzle or Unpaired-3, have been identified and characterized in Drosophila, much less is known regarding immunosuppressor cytokines. In a recent publication, we reported the identification of a novel cytokine, Diedel, which acts as systemic negative regulator of the IMD pathway. Here, we discuss the similarities between Diedel and WntD, another immunomodulatory cytokine and present evidence that the 2 molecules act independently from one another.
a CNRS UPR9022 , Institut de Biologie Moléculaire et Cellulaire , Strasbourg , France.
Olivier
O
Lamiable
a CNRS UPR9022 , Institut de Biologie Moléculaire et Cellulaire , Strasbourg , France.|b Faculté des Sciences de la Vie , Université de Strasbourg , Strasbourg , France.
Carine
C
Meignin
a CNRS UPR9022 , Institut de Biologie Moléculaire et Cellulaire , Strasbourg , France.|b Faculté des Sciences de la Vie , Université de Strasbourg , Strasbourg , France.
Jean-Luc
JL
Imler
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D016207:Cytokines / Q000276:immunology*; D029721:Drosophila Proteins / Q000276:immunology* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000276:immunology* / Q000382:microbiology / Q000821:virology; D007113:Immunity, Innate; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology*; D011971:Receptors, Immunologic / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D000943:Antigens, Differentiation; D016207:Cytokines; C000608275:Diedel protein, Drosophila; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; C499312:Myd88 protein, Drosophila; D011971:Receptors, Immunologic; C504611:WntD protein, Drosophila
Drosophila; IMD pathway; cytokines; innate immunity; virus