The double life of RIPK1.
We have recently identified receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) as an oncogenic driver in melanoma in addition to its well-established role in controlling cell survival and death. Our studies show that RIPK1 promotes melanoma cell proliferation through a positive feedback loop of NFKB1-BIRC2/BIRC3-RIPK1 powered by autocrine tumor necrosis factor.
School of Medicine and Public Health, The University of Newcastle , NSW, Australia.
Lei
L
Jin
School of Biomedical Sciences and Pharmacy, The University of Newcastle , NSW, Australia.
Jiezhong
J
Chen
School of Biomedical Sciences and Pharmacy, The University of Newcastle, NSW, Australia; School of Life Science, Anhui Medical University, Anhui, China.
Xiao Ying
XY
Liu
School of Medicine and Public Health, The University of Newcastle , NSW, Australia.
Chen Chen
CC
Jiang
School of Biomedical Sciences and Pharmacy, The University of Newcastle , NSW, Australia.
Xu Dong
XD
Zhang
Cell death; NF-κB; RIPK1; cell proliferation; death receptor; melanoma