Brachial Diparesis due to Motor Neuronopathy as One of the Predominant Presenting Signs of Occult Small Cell Lung Carcinoma.
Sensory neuronopathy is a well-established presentation in paraneoplastic neurological syndromes that is mostly associated with small cell lung cancer and anti-Hu antibodies. Motor neuronopathy, on the other hand, is an extremely rare observation in this syndrome. A 56-year-old man presented with asymmetric brachial diparesis and sensory ataxia. Electrophysiological studies revealed sensory ganglionopathy and progressive anterior horn degeneration in cervical segments. Small cell lung carcinoma with associated anti-Hu antibodies was later diagnosed. The patient did not improve despite the administration of steroids and chemotherapy. Paraneoplastic syndromes may exceptionally present with a bilateral arm weakness. Cases accompanied by sensory ganglionopathy should therefore be promptly investigated for any underlying malignancy.
Department of Neurology, Faculty of Medicine, Hacettepe University, Turkey.
Sefik Evren
SE
Erdener
Atay
A
Vural
Cagri Mesut
CM
Temucin
Sevim Erdem
SE
Ozdamar
Gulay
G
Nurlu
Kubilay
K
Varli
Nese
N
Dericioglu
D001259:Ataxia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009134:Muscular Atrophy, Spinal / Q000209:etiology* / Q000473:pathology; D055752:Small Cell Lung Carcinoma / Q000150:complications* / Q000473:pathology