Silencing FOXP2 in breast cancer cells promotes cancer stem cell traits and metastasis.
In a recent article in Cell Stem Cell, we showed that mesenchymal stem cells (MSCs), progenitor cells that populate the breast tumor stroma, induce microRNA-mediated FOXP2 repression in breast cancer cells (BCCs), thus promoting cancer stem cell (CSC) and metastatic traits. Here, we discuss the implications of these findings for understanding metastatic CSC genesis.
Division of Cancer Biology and Angiogenesis; Department of Pathology; Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA, USA.
Benjamin G
BG
Cuiffo
Division of Cancer Biology and Angiogenesis; Department of Pathology; Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Antoine E
AE
Karnoub
FOXP2; breast; cancer stem; forkhead; metastasis; microRNA; tumor initiation; tumor progression