TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling.
In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain.
María
M
Salazar
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain.
Mar
M
Lorente
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University ; Madrid, Spain.
Elena
E
García-Taboada
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre (I+12); Madrid, Spain.
Eduardo Pérez
EP
Gómez
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain.
David
D
Dávila
CIC bioGUNE, Bizkaia Technology Park ; Derio, Spain.
Patricia
P
Zúñiga-García
Department of Animal Surgery and Medicine; School of Veterinary; Complutense University ; Madrid, Spain.
Juana M
JM
Flores
Department of Animal Surgery and Medicine; School of Veterinary; Complutense University ; Madrid, Spain.
Antonio
A
Rodríguez
Institute of Biophysics; Hungarian Academy of Sciences ; Szeged, Hungary.
Zoltan
Z
Hegedus
CIC bioGUNE, Bizkaia Technology Park ; Derio, Spain.
David
D
Mosén-Ansorena
CIC bioGUNE-CIBERehd, Bizkaia Technology Park ; Derio, Spain.
Ana M
AM
Aransay
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain.
Sonia
S
Hernández-Tiedra
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain.
Israel
I
López-Valero
Instituto de Investigaciones Biomédicas Alberto Sols; Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM) ; Madrid, Spain.
Miguel
M
Quintanilla
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre (I+12); Madrid, Spain.
Cristina
C
Sánchez
Centre de Recherche en Carcérologie de Marseille (CRCM); INSERM UMR 1068, CNRS UMR 7258, Aix Marseille Université and Institut Paoli Calmette ; Marseille, France.
Juan L
JL
Iovanna
Centre de Recherche en Carcérologie de Marseille (CRCM); INSERM UMR 1068, CNRS UMR 7258, Aix Marseille Université and Institut Paoli Calmette ; Marseille, France.
Nelson
N
Dusetti
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) and Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS); Madrid, Spain.
Manuel
M
Guzmán
Department of Cardiovascular Science; University of Sheffield ; Sheffield, UK.
Sheila E
SE
Francis
CIC bioGUNE, Bizkaia Technology Park; Derio, Spain; Ikerbasque, Basque Foundation for Science; Bilbao, Spain; Biochemistry and Molecular Biology Department; University of the Basque Country (UPV/EHU); Bilbao, Spain.
Arkaitz
A
Carracedo
Department of Cardiovascular Science; University of Sheffield ; Sheffield, UK.
Endre
E
Kiss-Toth
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain.
Guillermo
G
Velasco
PTEN; Tribbles pseudokinases; animal models of cancer; prostate cancer; skin carcinogenesis