Cardiac surgery, a right target for hyperoxia?
In perioperative cardiac surgery period, supra-physiological arterial oxygen partial pressures is common practice, although there is no clear evidence of any benefit. Smit et al. have shown that a "conservative" approach did not improve hemodynamics, decrease oxidative stress or myocardial tissue damage, but was not associated with major deleterious event either. Here, we outline major oxygen friend or foes properties, which may partly explain the study results, and place the clinical trial from Smit et al. in a global context.
Service de Réanimation Médicale, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.|EA 7293, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Faculté de médecine, Université de Strasbourg, Strasbourg, France.
Julie
J
Boisramé-Helms
Institut für Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Universitätsklinikum Ulm, Helmholtzstrasse 8/1, 89081, Ulm, Germany.
Peter
P
Radermacher
Département de Réanimation Médicale et de Médecine Hyperbare Centre Hospitalier Universitaire, Angers, 49933, Cedex 9, France. PiAsfar@chu-angers.fr.|Laboratoire de Biologie Neurovasculaire et Mitochondriale Intégrée, CNRS UMR 6214-INSERM U1083, Université Angers, PRES L'UNAM, Angers, France. PiAsfar@chu-angers.fr.
Pierre
P
Asfar
D001424:Bacterial Infections / Q000517:prevention & control / Q000628:therapy; D006348:Cardiac Surgical Procedures / Q000379:methods*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D018496:Hyperoxia / Q000150:complications / Q000175:diagnosis*; D018384:Oxidative Stress / Q000502:physiology; D010100:Oxygen / Q000009:adverse effects* / Q000627:therapeutic use*
D010100:Oxygen