LAP: the protector against autoimmunity.
The autophagy-related process LC3-Associated Phagocytosis, or LAP, is known to control the degradation of engulfed cells and microorganisms. Now Martinez et al. discover that LAP controls immune responses to dying cells and its inhibition leads to development of Systemic Lupus Erythematosus-like disease.
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Urmi
U
Bandyopadhyay
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Michael
M
Overholtzer
D015551:Autoimmunity; D001343:Autophagy; D006801:Humans; D008180:Lupus Erythematosus, Systemic; D008869:Microtubule-Associated Proteins; D010587:Phagocytosis
D008869:Microtubule-Associated Proteins