Blocking α1-integrin reverts the adhesive phenotype of adult fibroblasts towards a foetal-like migratory phenotype.
Department of Molecular Cell Biology & Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Mariëlle
M
Walraven
Department of Molecular Cell Biology & Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Sandra J
SJ
van Vliet
Department of Molecular Cell Biology & Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Robert H J
RH
Beelen
Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands.
Marjolein
M
van Egmond
Association of Dutch Burn Centres, Beverwijk, The Netherlands.
Magda M W
MM
Ulrich
D002465:Cell Movement; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D039423:Integrin alpha1 / Q000502:physiology*; D010641:Phenotype; D061251:Primary Cell Culture
D039423:Integrin alpha1
fibroblast adhesion and migration; foetal fibroblast; myofibroblast persistence; scarless wound healing; α1‐integrin