Sustaining the spindle assembly checkpoint to improve cancer therapy.
To prevent chromosome segregation errors, the spindle assembly checkpoint (SAC) delays mitosis exit until proper spindle assembly. We found that the FCP1 phosphatase and its downstream target WEE1 kinase oppose the SAC, promoting mitosis exit despite malformed spindles. We further showed that targeting this pathway might be useful for cancer therapy.
CEINGE Biotecnologie Avanzate, Naples, Italy; IEOS, CNR, Naples, Italy.
Roberta
R
Visconti
CEINGE Biotecnologie Avanzate, Naples, Italy; DMMBM, University of Naples "Federico II", Naples, Italy.
Rosa
R
Della Monica
CEINGE Biotecnologie Avanzate, Naples, Italy; DMMBM, University of Naples "Federico II", Naples, Italy.
Domenico
D
Grieco
Apoptosis; FCP1; SAC; WEE1 inhibitor; spindle assembly checkpoint; taxane; vinca alkaloid