Anticonvulsant activity of methanolic and aqueous extracts of Melissa parviflora in experimentally induced Swiss albino mice.
The aim of the present study was to evaluate the anticonvulsant effect of whole plant extracts of Melissa parviflora using MES and PTZ induced seizures models. The dried whole plant was subjected to extraction in methanol and water. The extracts were subjected to phytochemical tests and the carbohydrate, flavonols, coumarins, glycosides and steroid were found to be present. The methanolic and aqueous extracts of the plant of Melissa parviflora were observed for their anticonvulsant activity by Maximal Electroshock seizures (MES) test and Pentylenetetrazole (PTZ) test using Swiss albino mice. Both the extracts showed significant activity in MES and PTZ induced convulsions in comparison to control. From the literature surveys as well experiments performed, it can be said that Melissa parviflora does pose anticonvulsant property.
Department of Ilmul-Advia, Faculty of Medicine (Unani), Jamia Hamdard, New Delhi, India - 110062.
Jalal Uddin
JU
Bhat
Department of Ilmul-Advia, Faculty of Medicine (Unani), Jamia Hamdard, New Delhi, India - 110062.
Qudsia
Q
Nizami
Department of Biochemistry, Faculty of Science, University of Kashmir, Srinagar, J&K, India - 190006.
Asia
A
Asiaf
Department of Pharmacognosy & Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India - 110062.
Shabir Ahmad
SA
Parray
Department of Medical Elementology & Toxicology, Jamia Hamdard, New Delhi, India - 110062.
Shiekh Tanveer
ST
Ahmad
Department of Ilmul-Advia, Faculty of Medicine (Unani), Jamia Hamdard, New Delhi, India - 110062.
Mohammad
M
Aslam
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India -110062.
Razia
R
Khanam
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India -110062.
Mohammad
M
Mujeeb
Department of Medical Elementology & Toxicology, Jamia Hamdard, New Delhi, India - 110062.
Sadiq
S
Umar
Department of Ilmul-Advia, Faculty of Medicine (Unani), Jamia Hamdard, New Delhi, India - 110062.
Ayesha
A
Siddiqi
Melissa parviflora; anticonvulsant effects; maximal electroshock; pentylenetetrazole