[IgA nephropathy].
IgA nephropathy is the most common form of primary glomerulonephritis worldwide and an important cause of chronic kidney disease and end-stage kidney failure. Its pathophysiology remains in part unsolved but it is recognized as an immune complex disease. Recent years have brought progress in the field through the discovery of several genetic susceptibility loci and the formulation of the multi-hit pathogenesis model. Presentation, clinical course and histology can be extremely variable, making any histological classification still difficult. Indeed, most therapeutic studies until now include patients based only on the severity of clinical criteria but the new classification of Oxford should change that. Only the management of patients with nephropathy with minimal change glomerular lesions and nephrotic syndrome, or extra-capillary glomerulonephritis and rapidly progressive renal failure, is consensual: Corticosteroids alone for the first and associated with immunosuppressive drugs for the latter. The recent Kidney Disease Improving Global Outcomes (KDIGO) consensus treatment guideline is still controversial, especially in light of the last clinical studies. Corticosteroid therapy can be discussed in patients with proteinuria greater than 1 g/day without renal failure. All IgA nephropathy patients should benefit from the global management of chronic glomerular disease, including a renin-angiotensin system blocker in the presence of hypertension or proteinuria.
Service de néphrologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: evangeline.pillebout@aphp.fr.
Evangéline
E
Pillebout
Service d'anatomie pathologique, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
Jérôme
J
Vérine
D003663:Decision Trees; D019587:Dietary Supplements; D005395:Fish Oils; D005922:Glomerulonephritis, IGA / Q000175:diagnosis* / Q000628:therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012084:Renin-Angiotensin System / Q000187:drug effects
D005395:Fish Oils; D005938:Glucocorticoids; D007166:Immunosuppressive Agents
Bloqueurs du système rénine-angiotensine; Chronic kidney disease; Dépôts mésangiaux; Glomérulonéphrite; Hematuria; Hématurie; IgA; Insuffisance rénale chronique; Nephropathy; Néphropathie; Primary glomerulonephritis; Renine-angiotensin-aldosterone blockers