A case of chronic myeloid leukaemia in blast transformation with leukemic ascites.
Chronic Myeloid Leukaemia (CML) is a disease characterised by a distinctive marker that is the Philadelphia Chromosome and an ability to transform into blast phase, which confers a poor prognosis. The median survival was reported to be between three to six months in correlation to blast phase. Extramedullary involvement with CML to sites such as pleural, meningeal and bones have been reported. We report a case of 41-year-old man who was diagnosed with CML in blast phase and presented with ascites. Ultrasound of abdomen showed coarse echotexture of liver suggestive leukaemic infiltration to the liver. The liver profile was severely deranged and associated with coagulopathy. Flow cytometry analysis of the peritoneal fluid revealed presence of myeloblasts consistent with CML in blast crisis with leukaemic ascites. Bone marrow biopsy also confirmed disease transformation. He received standard induction chemotherapy for acute myeloid leukaemia with dose modifications based on liver enzymes performance. Our case highlights an unusual presentation of CML in blast crisis with leukaemic ascites and the challenges in managing cytotoxic treatments due to the liver infiltration.
Pusat Perubatan Universiti Kebangsaan Malaysia, Department of Internal Medicine, Jalan Yaakob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia. ridzuan.said85@gmail.com.
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Mohd Ridzuan
Pusat Perubatan Universiti Kebangsaan Malaysia, Department of Internal Medicine, Jalan Yaakob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.
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Yap
Pusat Perubatan Universiti Kebangsaan Malaysia, Department of Internal Medicine, Jalan Yaakob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.
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Wan Fariza
Pusat Perubatan Universiti Kebangsaan Malaysia, Department of Internal Medicine, Jalan Yaakob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.
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Fadilah
University Kebangsaan Malaysia Medical Centre, Department of Pathology, Kuala Lumpur, Malaysia.
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Salwati
D000328:Adult; D001201:Ascites / Q000209:etiology*; D001752:Blast Crisis; D001853:Bone Marrow; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008213:Lymphocyte Activation; D008297:Male