Targeting Cancer Cells with Photoactive Silica Nanoparticles.
This review highlights recent advances in the preparation of silica nanoparticles (SNPs) functionalized with porphyrins and phthalocyanines for application in cancer photodiagnostic and photodynamic therapy (PDT). The use of photosensitizer-SNP formulations has emerged recently as a new nanomedicine for cancer research owing to their unique physicochemical properties, which make them useful for photo-biomedical applications. In order to study their photobiological properties, diverse chemical strategies involving covalent and non-covalent bonding have been used to load photosensitizers in/on SNPs.
Wioleta
W
Borzęcka
Tito
T
Trindade
Tomás
T
Torres
Department of Chemical Engineering, Instituto Superior Técnico, University of Lisbon, Av. Rovisco Pais, 1049-001 Lisbon, Portugal.
João
J
Tomé
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D054833:Isoindoles; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology; D012822:Silicon Dioxide / Q000737:chemistry / Q000494:pharmacology*
D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; D011166:Porphyrins; D012822:Silicon Dioxide; C013647:phthalocyanine