Electrocardiography-Derived Predictors for Therapeutic Response to Treatment in Children with Postural Tachycardia Syndrome.
To explore whether electrocardiography (ECG) variables could be used to predict responses to physical treatment in children with postural tachycardia syndrome (POTS).



Forty children with POTS and 32 healthy controls were enrolled in this study. General information and hemodynamic and supine ECG variables, including QT interval dispersion (QTd), were collected. The children with POTS received physical treatment and 3 months of follow-up. A receiver-operating characteristic curve was used to evaluate the value of ECG variables for predicting the effectiveness of physical treatment.



Compared with the healthy children, the children with POTS had longer baseline QTd and heart rate (HR)-corrected QTd (QTcd), but shorter minimum QT intervals (QTmin) and minimum HR-corrected QT intervals (P < .05). In children with POTS, responders to physical treatment had a longer baseline time between QRS complexes (RR) interval of minimum QT interval and a longer QTcd compared with nonresponders. A longer QTcd was a significant risk factor for the presence of POTS (OR, 1.022; P = .02) and for undesirable responses to physical treatment in children with POTS (OR, 1.044; P = .03). Baseline QTcd was positively correlated with the HR elevation from supine to upright seen in children with POTS (r = 0.348; P = .003). Receiver operating characteristic curve analysis demonstrated an area under the curve of 0.73, and using 43.0 msec as a cutoff of QTcd yielded a sensitivity of 90% and a specificity of 60%.



QTcd might be useful for predicting the effectiveness of physical treatment for POTS in children.
Department of Pediatrics, Peking University First Hospital, Beijing, China.
Wenxin
W
Lu
Department of Pediatrics, Peking University First Hospital, Beijing, China.
Hui
H
Yan
Department of Pediatrics, Peking University First Hospital, Beijing, China.
Shu
S
Wu
Division of Biological Sciences, University of California San Diego, La Jolla, CA.
Selena
S
Chen
Department of Pediatrics, Peking University First Hospital, Beijing, China.
Wenrui
W
Xu
Department of Pediatrics, Peking University First Hospital, Beijing, China.
Hongfang
H
Jin
Department of Pediatrics, Peking University First Hospital, Beijing, China. Electronic address: junbaodu1@126.com.
Junbao
J
Du
D000293:Adolescent; D002648:Child; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D026741:Physical Therapy Modalities; D054972:Postural Orthostatic Tachycardia Syndrome / Q000503:physiopathology* / Q000628:therapy*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D016896:Treatment Outcome
QT interval dispersion; autonomic function; electrocardiography