Insights into the molecular roles of heparan sulfate proteoglycans (HSPGs-syndecans) in autocrine and paracrine growth factor signaling in the pathogenesis of Hodgkin's lymphoma.
Syndecans (SDC, SYND) comprise a group of four structurally related type 1 transmembrane heparan sulfate proteoglycans (HSPGs) that play important roles in tumorigenic processes. SDCs exert signaling via their protein cores and their conserved transmembrane and cytoplasmic domains or by forming complexes with growth factors (GFs). In classical Hodgkin's lymphoma (cHL), a lymphoid neoplasm of predominantly B cell origin, SDC1 and SDC4 are the active SDCs, and a number of GF (vascular endothelial growth factor, fibroblast growth factor, etc.) signaling pathways have been studied. However, despite extensive pre-clinical and clinical research on SDC-mediated GF signaling in many cancer types, there is very limited data for this interaction in cHL. Thus, this review highlights the relevant literature focusing on the potential interactions of SDCs and GFs in cHL pathogenesis. Also discussed are the pre-clinical and clinical studies targeting signaling through these pathways.
Department of Biological Sciences, Bronx Community College of The City University of New York, Bronx, NY, 10453, USA. rajendra.gharbaran@bcc.cuny.edu.
Rajendra
R
Gharbaran
D000818:Animals; D006689:Hodgkin Disease / Q000209:etiology*; D006801:Humans; D008246:Lysophospholipids / Q000502:physiology; D018919:Neovascularization, Physiologic; D017526:Receptor, IGF Type 1 / Q000502:physiology; D017479:Receptors, Platelet-Derived Growth Factor / Q000502:physiology; D040262:Receptors, Vascular Endothelial Growth Factor / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000502:physiology; D053668:Syndecan-1 / Q000032:analysis / Q000502:physiology*; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D008246:Lysophospholipids; C508241:SDC1 protein, human; D053668:Syndecan-1; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13; D042461:Vascular Endothelial Growth Factor A; C060506:sphingosine 1-phosphate; D017526:Receptor, IGF Type 1; D017479:Receptors, Platelet-Derived Growth Factor; D040262:Receptors, Vascular Endothelial Growth Factor; D013110:Sphingosine
Autocrine; CD138; Cancer; Growth factors; Heparan sulfate proteoglycans; Hodgkin's lymphoma; Paracrine; Syndecan-1