Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis.
Many protein folding diseases are intimately associated with accumulation of amyloid aggregates. The amyloid materials formed by different proteins/peptides share many structural similarities, despite sometimes large amino acid sequence differences. Some amyloid diseases constitute risk factors for others, and the progression of one amyloid disease may affect the progression of another. These connections are arguably related to amyloid aggregates of one protein being able to directly nucleate amyloid formation of another, different protein: the amyloid cross-interaction. Here, we discuss such cross-interactions between the Alzheimer disease amyloid-β (Aβ) peptide and other amyloid proteins in the context of what is known from in vitro and in vivo experiments, and of what might be learned from clinical studies. The aim is to clarify potential molecular associations between different amyloid diseases. We argue that the amyloid cascade hypothesis in Alzheimer disease should be expanded to include cross-interactions between Aβ and other amyloid proteins.
From the Chemical Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom, jinghui.luo.86@gmail.com.
Jinghui
J
Luo
the Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm, Sweden.
Sebastian K T S
SK
Wärmländer
the Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm, Sweden.
Astrid
A
Gräslund
the Biozentrum, University of Basel, CH-4056 Basel, Switzerland, and the Laboratory of Biomolecular Research, Paul Scherrer Institute, CH-5232 Villigen, Switzerland jan-pieter.abrahams@psi.ch.
Jan Pieter
JP
Abrahams
D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D006801:Humans; D066263:Protein Aggregation, Pathological / Q000378:metabolism*
D016229:Amyloid beta-Peptides
Alzheimer disease; amyloid; amyloid-beta (Aβ); cross-amyloid interaction; fibrillation; oligomer; oligomerization