Biogenesis of Micronuclei.
The presence of micronuclei in a cell is an indicator of DNA damage and genetic instability. In this review, mechanisms of emergence of micronuclei, their functional activity, and pathways of elimination are discussed. It is supposed that morphological and functional varieties of micronuclei as well as their degradation pathways can be determined by the chromosomal material localized inside these cell structures.
Lomonosov Moscow State University, Faculty of Biology, Moscow, 119234, Russia. evgengeva@mail.ru.
O P
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Kisurina-Evgenieva
O I
OI
Sutiagina
G E
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Onishchenko
D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage / Q000187:drug effects / Q000528:radiation effects; D004260:DNA Repair; D005720:Gamma Rays; D006570:Heterochromatin / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007399:Interphase; D009153:Mutagens / Q000633:toxicity; D009685:Nuclear Envelope / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
D006570:Heterochromatin; D009153:Mutagens; D017382:Reactive Oxygen Species