18F-FDG PET/CT and functional MRI in a case of crossed logopenic primary progressive aphasia.
Primary progressive aphasia is a clinical syndrome caused by a neurodegeneration of areas and neural networks involved in language, usually in the left hemisphere. The term "crossed aphasia" denotes an acquired language dysfunction caused by a lesion in the hemisphere ipsilateral to the dominant hand. A case is presented on a 75-year-old right-handed woman with a logopenic variant of primary progressive aphasia with word-finding difficulties of 2 years onset. The18F-FDG PET/CT showed right temporoparietal hypometabolism. A functional MRI scan was performed during a verb naming task in order to characterise language lateralisation patterns. A similar activation pattern was observed in both hemispheres, with less activation than expected in bilateral inferior frontal gyrus. These findings support that logopenic variant of primary progressive aphasia should not be considered as a neurodegeneration starting in the left brain hemisphere, but as a syndrome characterised by asymmetric neurodegeneration of brain regions and neural networks involved in language.
Servicio de Medicina Nuclear, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria San Carlos, Madrid, España. Electronic address: mncabreram@hotmail.com.
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MN
Cabrera-Martín
Servicio de Neurología, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria San Carlos, Madrid, España.
J A
JA
Matías-Guiu
Servicio de Radiodiagnóstico, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria San Carlos, Madrid, España.
M
M
Yus-Fuertes
Servicio de Neurología, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria San Carlos, Madrid, España.
M
M
Valles-Salgado
Servicio de Neurología, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria San Carlos, Madrid, España.
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T
Moreno-Ramos
Servicio de Neurología, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria San Carlos, Madrid, España.
J
J
Matías-Guiu
Servicio de Medicina Nuclear, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria San Carlos, Madrid, España.
J L
JL
Carreras Delgado
D000368:Aged; D018888:Aphasia, Primary Progressive / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
(18)F-FDG PET-CT; Afasia cruzada; Afasia progresiva primaria variante logopénica; Crossed aphasia; Functional MRI; Language lateralization; Lateralización del lenguaje; Logopenic variant of primary progressive aphasia; PET-TC (18)F-FDG; RM funcional