p53 isoforms change p53 paradigm.
Although p53 defines cellular responses to cancer treatment it is not clear how p53 can be used to control cell fate outcome. Data demonstrate that so-called p53 does not exist as a single protein, but is in fact a group of p53 protein isoforms whose expression can be manipulated to control the cellular response to treatment.
University of Dundee; College of Medicine; Division of Cancer Research; Dundee Cancer Centre ; Dundee, United Kingdom.
J C
JC
Bourdon
SRSF1; cancer; cdc2-like-kinase; clk; p63; p73; splicing