[LABORATORY AND EXPERIMENTAL STUDY OF THE COMPLEX PROBIOTIC PREPARATION "BIFILACT-BILS" IN CAPSULATED FORM].
The composition and technology of complex probiotic in hard gelatin capsules was developed in Perm Branch "Biomed" of "Microgen" State Company. The preparation contains three production strains: Lactobacillus plantarum 8P-A3, L. acidophilus K3W24 and Bifidobacterium bifidum 1. Laboratory and experimental (preclinical) study of the probiotic included investigation of the antagonistic activity, "acute" and "chronic" toxicity, the effect of the preparation on histology and hematology of laboratory animals. The result of these studies suggested of the probiotic had high inhibitory activity against pathogenic microflora when compared with probiotic monopreparations and had no toxic effects on laboratory animals.
V A
VA
Neschislyaev
M G
MG
Stolbova
P A
PA
Mokin
E V
EV
Orlova
A E
AE
Ershov
D000284:Administration, Oral; D000818:Animals; D000898:Antibiosis; D002214:Capsules; D055808:Drug Discovery / Q000379:methods*; D051379:Mice; D008826:Microbial Sensitivity Tests; D019936:Probiotics / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D023382:Toxicity Tests, Acute; D036401:Toxicity Tests, Chronic
D002214:Capsules