Toppling high-grade pulmonary neuroendocrine tumors with a DLL3-targeted trojan horse.
Delta-like protein 3 (DLL3) is a novel and tractable tumor-initiating cell-associated target for the antibody-drug conjugate SC16LD6.5 in high-grade pulmonary neuroendocrine tumors. Elevated expression of DLL3, an inhibitor of Notch pathway activation, marks the second recent observation that impairment of Notch receptor signaling may play a critical role in neuroendocrine tumorigenesis.
Stemcentrx Inc. , 450 East Jamie Court , South San Francisco, CA, USA.
Scott J
SJ
Dylla
DLL3; Notch; SCLC; TIC; Tumor-initiating cell