The evolution of innate lymphoid cells.
Innate lymphoid cells (ILCs) are the most recently discovered group of immune cells. Understanding their biology poses many challenges. We discuss here the current knowledge on the appearance of ILC subsets during evolution and propose how the connection between ILCs and T cells contributes to the robustness of immunity and hence to the fitness of the hosts.
Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.|Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
Eric
E
Vivier
Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.
Serge A
0000-0002-7147-4380
SA
van de Pavert
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Max D
MD
Cooper
The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.|Department of Medical Biology, University of Melbourne, Parkville, Australia.
Gabrielle T
GT
Belz
D000818:Animals; D005075:Biological Evolution; D002454:Cell Differentiation; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D016131:Lymphocyte Subsets / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*