Modeling Alzheimer's Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns.
Alzheimer's disease (AD) is the most prevalent type of dementia and its pathology is characterized by deposition of extracellular β-amyloid plaques, intracellular neurofibrillary tangles, and extensive neuron loss. While only a few familial AD cases are due to mutations in three causative genes (APP, PSEN1, and PSEN2), the ultimate cause behind the rest of the cases, called sporadic AD, remains unknown. Current animal and cellular models of human AD, which are based on the Aβ and tau hypotheses only, partially resemble the familial AD. As a result, there is a pressing need for the development of new models providing insights into the pathological mechanisms of AD and for the discovery of ways to treat or delay the onset of the disease. Recent preclinical research suggests that stem cells can be used to model AD. Indeed, human induced pluripotent stem cells can be differentiated into disease-relevant cell types that recapitulate the unique genome of a sporadic AD patient or family member. In this review, we will first summarize the current research findings on the genetic and pathological mechanisms of AD. We will then highlight the existing induced pluripotent stem cell models of AD and, lastly, discuss the potential clinical applications in this field.
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Weiwei
W
Zhang
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Bin
B
Jiao
State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410008, China.
Miaojin
M
Zhou
State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410008, China.
Tao
T
Zhou
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410008, China.
Lu
L
Shen