Novel benzimidazol-2-ylidene carbene precursors and their silver(I) complexes: Potential antimicrobial agents.
Novel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors, these NHC precursors were metallated with Ag2O in dichloromethane at room temperature to give novel silver(I)-NHC complexes. Structures of these benzimidazolium salts and silver(I)-NHC complexes were characterized on the basis of elemental analysis, (1)H NMR, (13)C NMR, IR and LC-MS spectroscopic techniques. A series of benzimidazolium salts and silver(I)-NHC complexes were tested against standard bacterial strains: Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and the fungal strains: Candida albicans and Candida tropicalis. The results showed that benzimidazolium salts inhibited the growth of all bacteria and fungi strains and all silver(I)-NHC complexes performed good activities against different microorganisms.
İnönü University, Catalysis Research and Application Center, 44280 Malatya, Turkey; İnönü University, Faculty of Science and Arts, Department of Chemistry, 44280 Malatya, Turkey.
Murat
M
Kaloğlu
İnönü University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 44280 Malatya, Turkey.
Nazan
N
Kaloğlu
İnönü University, Faculty of Science and Arts, Department of Chemistry, 44280 Malatya, Turkey.
İlknur
İ
Özdemir
İnönü University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, 44280 Malatya, Turkey.
Selami
S
Günal
İnönü University, Catalysis Research and Application Center, 44280 Malatya, Turkey; İnönü University, Faculty of Science and Arts, Department of Chemistry, 44280 Malatya, Turkey. Electronic address: ismail.ozdemir@inonu.edu.tr.
İsmail
İ
Özdemir
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012834:Silver / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods; D013211:Staphylococcus aureus / Q000187:drug effects
D000890:Anti-Infective Agents; D001562:Benzimidazoles; D012834:Silver
Benzimidazolium salts; Metallopharmaceuticals in vitro antimicrobial activity; N-Heterocyclic carbene; Silver(I)–NHC complexes