Keeping autophagy in cheCK1.
Mutant RAS-driven cancer cells cope with proliferative stress by increasing basal autophagy to maintain protein/organelle and energy homeostasis. We recently demonstrated that casein kinase 1 alpha (CK1α), a therapeutically tractable enzyme, is critical for fine-tuning the transcriptional regulation of mutant RAS-induced autophagy and the development of mutant RAS-driven cancers.
Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School , Singapore.
Jit Kong
JK
Cheong
Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School , Singapore.
David M
DM
Virshup
Autophagy; RAS; cancer; casein kinase 1; phosphorylation