Linking apoptosis to cancer metabolism: Another missing piece of JuNK.
Cancer cells become dependent on aerobic glycolysis to sustain rapid proliferation and escape apoptosis. How this metabolic change, also known as the Warburg effect, is linked to apoptosis remains largely unknown. Our new data place c-Jun N-terminal kinase in the center of a hub regulating apoptosis and cancer metabolism.
Cell Signaling and Cancer Laboratory, Institute of Hepatology London , UK.
Salvatore
S
Papa
Department of Life Sciences, Division of Biosciences, College of Health and Life Sciences, Brunel University London , Uxbridge, UK.
Concetta
C
Bubici
Aerobic glycolysis; JNK; PARP14; PKM2; cancer