Reward disrupts reactivated human skill memory.
Accumulating evidence across species and memory domains shows that when an existing memory is reactivated, it becomes susceptible to modifications. However, the potential role of reward signals in these mechanisms underlying human memory dynamics is unknown. Leaning on a wealth of findings on the role of reward in reinforcing memory, we tested the impact of reinforcing a skill memory trace with monetary reward following memory reactivation, on strengthening of the memory trace. Reinforcing reactivated memories did not strengthen the memory, but rather led to disruption of the memory trace, breaking down the link between memory reactivation and subsequent memory strength. Statistical modeling further revealed a strong mediating role for memory reactivation in linking between memory encoding and subsequent memory strength only when the memory was replayed without reinforcement. We suggest that, rather than reinforcing the existing memory trace, reward creates a competing memory trace, impairing expression of the original reward-free memory. This mechanism sheds light on the processes underlying skill acquisition, having wide translational implications.
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Eran
E
Dayan
School of Psychological Sciences and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv 69978, Israel.
Rony
R
Laor-Maayany
School of Psychological Sciences and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv 69978, Israel.
Nitzan
N
Censor
D006801:Humans; D008568:Memory; D012201:Reward; D020377:Self Efficacy; D013647:Task Performance and Analysis