Modulating Cholesterol Homeostasis to Build a Better T Cell.
There is great interest in discovering targets for in vitro manipulation of autologous T cells that enhance their cytotoxicity against tumor targets as a potent cancer immunotherapy. In a recent Nature paper, Xu and colleagues reveal new insights into the link between cellular cholesterol metabolism and CD8 T cell functions.
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yoko
Y
Kidani
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: sbensinger@mednet.ucla.edu.
Steven J
SJ
Bensinger
D000101:Acetyl-CoA C-Acetyltransferase / Q000378:metabolism; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D006706:Homeostasis; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008954:Models, Biological
D002784:Cholesterol; D000101:Acetyl-CoA C-Acetyltransferase