Protective Effects of Lithium on Sumatriptan-Induced Memory Impairment in Mice.
Lithium is a drug used for the treatment of bipolar disorder. It has several mechanisms of action, and recently it is shown that lithium can antagonize the 5-HT1B/1D serotonin receptors. Sumatriptan is a 5-HT1B/1D receptor agonist used for the treatment of cluster headaches and migraine which might cause memory impairment as a potential side effect. In this study, effects of lithium on sumatriptan-induced memory impairment have been determined in a two-trial recognition Y-maze and passive avoidance tests. Male mice weighing 25-30 g were divided into several groups randomly. In Y-maze test, effects of lithium (1,5,10,20,40,80 mg/kg) and sumatriptan (1,5,10 mg/kg) were assessed on memory acquisition, then lithium (0.1,1,10 mg/kg) and sumatriptan (1,10 mg/kg) were studied in passive avoidance test. Effects of lithium (1mg/kg) on sumatriptan (10 mg/kg)-induced memory impairment were studied in both of tests. The present study demonstrated that sumatriptan impaired memory in Y-maze and passive avoidance tests (P<0.05, P<0.01, respectively). Lithium did not show any significant effect on memory function compared to saline-treated control group in both tests (P>0.05), but significantly reversed sumatriptan-induced memory impairment in Y-maze and passive avoidance tests (P<0.001, P<0.05, respectively). It is concluded that lithium reverses the sumatriptan-induced memory impairment probably through 5-HT1B/1D receptors antagonism.
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Vahid
V
Nikoui
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mehrak
M
Javadi-Paydar
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mahtab
M
Salehi
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Selda
S
Behestani
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Ahmad-Reza
AR
Dehpour
D000818:Animals; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000517:prevention & control*; D051379:Mice; D044302:Receptor, Serotonin, 5-HT1B / Q000187:drug effects; D018170:Sumatriptan / Q000633:toxicity*
D044302:Receptor, Serotonin, 5-HT1B; D018170:Sumatriptan; D008094:Lithium
5-HT1B/1D; Lithium; Mice; Spatial recognition memory; Sumatriptan