Cu(I)-Catalyzed Enantioselective Friedel-Crafts Alkylation of Indoles with 2-Aryl-N-sulfonylaziridines as Alkylating Agents.
A highly enantioselective Friedel-Crafts alkylation of indoles with N-sulfonylaziridines as alkylating agents has been developed by utilizing the complex of Cu(CH3CN)4BF4/(S)-Segphos as a catalyst. A range of optically active tryptamine derivatives are obtained in good to excellent yields and enantioselectivities (up to >99% ee) via a kinetic resolution process.
College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
Chen
C
Ge
College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
Ren-Rong
RR
Liu
College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
Jian-Rong
JR
Gao
College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, China.
Yi-Xia
YX
Jia