Antispastic Management in Arterial Grafts in Coronary Artery Bypass Grafting Surgery.
Arterial grafts have long-term patency superior to vein grafts but have a tendency to develop spasm that can lead to potentially life-threatening complications. A perfect antispastic protocol should include advanced surgical technique and adequate pharmacologic methods. All pharmacologic vasodilator drugs relax the vessel through specific mechanisms, and therefore, there is no perfect, single best vasodilator to prevent or treat spasm of the arterial graft against all mechanisms of contraction. One of the choices is to use a combination of pharmacologic vasodilators targeting different mechanisms of spasm to obtain the reliable and best effect.
Department of Cardiovascular Surgery and Center for Basic Medical Research, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin and Zhejiang University and The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China, and Department of Surgery, Oregon Health and Science University, Portland, Oregon. Electronic address: gwhezj@163.com.
Guo-Wei
GW
He
Department of Cardiothoracic Surgery, Oxford University, United Kingdom.
David P
DP
Taggart
D001026:Coronary Artery Bypass / Q000379:methods*; D003324:Coronary Artery Disease / Q000601:surgery; D006083:Graft Occlusion, Vascular / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D017534:Radial Artery / Q000187:drug effects / Q000637:transplantation*; D014654:Vascular Patency / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents