STAT1-mediated translational control in tumor suppression and antitumor therapies.
Signal transducer and activator of transcription (STAT1) functions as a tumor suppressor but paradoxically protects tumor cells from death induced by DNA damaging drugs. An important mechanism employed by Stat1 to exert its tumor suppressor and cytoprotective effects involves translation of select mRNAs encoding proteins with either antitumor or prosurvival properties.
Lady Davis Institute for Medical Research, McGill University, Sir Mortimer B. Davis-Jewish General Hospital , Montreal, Quebec, Canada.
Shuo
S
Wang
Lady Davis Institute for Medical Research, McGill University, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada; Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Antonis E
AE
Koromilas
Antitumor therapies; STAT1; cell survival; chemotherapeutic drugs; gene transcription; mRNA translation initiation; protein phosphorylation