Pathological laughing and crying in amyotrophic lateral sclerosis is related to frontal cortex function.
The syndrome of pathological laughing and crying (PLC) is characterized by episodes of involuntary outbursts of emotional expression. Although this phenomenon has been referred to for over a century, a clear-cut clinical definition is still lacking, and underlying pathophysiological mechanisms are not well understood. In particular, it remains ill-defined which kind of stimuli-contextually appropriate or inappropriate-elicit episodes of PLC, and if the phenomenon is a result of a lack of inhibition from the frontal cortex ("top-down-theory") or due to an altered processing of sensory inputs at the brainstem level ("bottom-up-theory"). To address these questions, we studied ten amyotrophic lateral sclerosis (ALS) patients with PLC and ten controls matched for age, sex and education. Subjects were simultaneously exposed to either emotionally congruent or incongruent visual and auditory stimuli and were asked to rate pictures according to their emotional quality. Changes in physiological parameters (heart rate, galvanic skin response, activity of facial muscles) were recorded, and a standardized self-assessment lability score (CNS-LS) was determined. Patients were influenced in their rating behaviour in a negative direction by mood-incongruent music. Compared to controls, they were influenced by negative stimuli, i.e. they rated neutral pictures more negatively when listening to sad music. Patients rated significantly higher on the CNS-LS. In patients, changes of electromyographic activity of mimic muscles during different emotion-eliciting conditions were explained by frontal cortex dysfunction. We conclude that PLC is associated with altered emotional suggestibility and that it is preferentially elicited by mood-incongruent stimuli. In addition, physiological reactions as well as behavioural changes suggest that this phenomenon is primarily an expression of reduced inhibitory activity of the frontal cortex, since frontal dysfunction could explain changes in physiological parameters in the patient group. We consider these findings being important for the clinical interpretation of emotional reactions of ALS patients.
Department of Neurology, University Hospital of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany. annemarie.huebers@uni-ulm.de.
Annemarie
A
Hübers
Department of Neurology, University Hospital of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Jan
J
Kassubek
Department of Psychiatry, University Hospital of Ulm, Leimgrubenweg 12-14, 89073, Ulm, Germany.
Georg
G
Grön
Department of Neurology, University Hospital of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Martin
M
Gorges
Department of Neurology, University Hospital of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Helena
H
Aho-Oezhan
Department of Neurology, University Hospital of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Jürgen
J
Keller
Department of Neurology, University Hospital of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Hannah
H
Horn
Department of Neurology, University Hospital of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Hermann
H
Neugebauer
Department of Neurology, University Hospital of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Ingo
I
Uttner
Department of Neurology, University Hospital of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Dorothée
D
Lulé
Department of Neurology, University Hospital of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Albert C
AC
Ludolph
D000328:Adult; D000342:Affective Symptoms / Q000150:complications / Q000503:physiopathology*; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000503:physiopathology*; D003448:Crying / Q000502:physiology*; D004576:Electromyography; D005152:Facial Muscles / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D005712:Galvanic Skin Response; D006339:Heart Rate; D000070276:Heart Rate Determination; D006801:Humans; D007845:Laughter / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D013577:Syndrome
Amyotrophic lateral sclerosis; Emotion induction; Frontal cortex; Pathological laughing and crying; Pseudobulbar affect