Impact of acetylation on tumor metabolism.
Acetylation of protein lysine residues is a reversible and dynamic process that is controlled by histone acetyltransferases (HATs) and deacetylases (HDACs and SIRTs). Recent studies have revealed that acetylation modulates not only nuclear proteins but also cytoplasmic or mitochondrial proteins, including many metabolic enzymes. In tumors, cellular metabolism is reprogrammed to provide intermediates for biosynthesis such as nucleotides, fatty acids, and amino acids, and thereby favor the rapid proliferation of cancer cells and tumor development. An increasing number of investigations have indicated that acetylation plays an important role in tumor metabolism. Here, we summarize the substrates that are modified by acetylation, especially oncogenes, tumor suppressor genes, and enzymes that are implicated in tumor metabolism.
Key Laboratory of Molecular Medicine; Ministry of Education, and Department of Biochemistry and Molecular Biology; Fudan University Shanghai Medical College; Shanghai, People's Republic of China; Molecular and Cell Biology Lab; Institutes of Biomedical Sciences; Fudan University; Shanghai, People's Republic of China.
Di
D
Zhao
Key Laboratory of Molecular Medicine; Ministry of Education, and Department of Biochemistry and Molecular Biology; Fudan University Shanghai Medical College; Shanghai, People's Republic of China; Molecular and Cell Biology Lab; Institutes of Biomedical Sciences; Fudan University; Shanghai, People's Republic of China.
Fu-Long
FL
Li
Key Laboratory of Molecular Medicine; Ministry of Education, and Department of Biochemistry and Molecular Biology; Fudan University Shanghai Medical College; Shanghai, People's Republic of China; Molecular and Cell Biology Lab; Institutes of Biomedical Sciences; Fudan University; Shanghai, People's Republic of China.
Zhou-Li
ZL
Cheng
Key Laboratory of Molecular Medicine; Ministry of Education, and Department of Biochemistry and Molecular Biology; Fudan University Shanghai Medical College; Shanghai, People's Republic of China; Molecular and Cell Biology Lab; Institutes of Biomedical Sciences; Fudan University; Shanghai, People's Republic of China.
Qun-Ying
QY
Lei
acetylation; metabolic enzyme; oncogene; tumor metabolism; tumor suppressor