MKP1 mediates resistance to therapy in HER2-positive breast tumors.
Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer. MKP1 expression is inducible in radiation-treated breast cancer cells, and correlates with human epidermal growth factor receptor 2 (ERBB2, HER2) expression. The role of MKP1 in therapy resistance suggests that targeting MKP1 in HER2-positive breast tumors may significantly enhance the efficacy of anti-HER2 and other anticancer therapies.
School of Medicine; Department of Radiation Oncology; NCI-designated Comprehensive Cancer Center; University of California Davis ; Sacramento, CA, USA.
Demet
D
Candas
School of Medicine; Department of Radiation Oncology; NCI-designated Comprehensive Cancer Center; University of California Davis ; Sacramento, CA, USA.
Jian Jian
JJ
Li
HER2; MKP1; breast cancer; mitochondria; radioresistance