Molecular interaction of δ-conopeptide EVIA with voltage-gated Na(+) channels.
Eduard-Zintl-Institute of Inorganic and Physical Chemistry, Technische Universität Darmstadt, Alarich-Weiss-Str. 4, D-64287 Darmstadt, Germany.
Daniel
D
Tietze
Department of Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Str. 2, D-07745 Jena, Germany.
Enrico
E
Leipold
Pharmaceutical Chemistry I, Pharmaceutical Institute, University of Bonn, Brühler Str. 7, D-53119 Bonn, Germany.
Pascal
P
Heimer
Pharmaceutical Chemistry I, Pharmaceutical Institute, University of Bonn, Brühler Str. 7, D-53119 Bonn, Germany.
Miriam
M
Böhm
Eduard-Zintl-Institute of Inorganic and Physical Chemistry, Technische Universität Darmstadt, Alarich-Weiss-Str. 4, D-64287 Darmstadt, Germany.
Wadim
W
Winschel
Pharmaceutical Chemistry I, Pharmaceutical Institute, University of Bonn, Brühler Str. 7, D-53119 Bonn, Germany.
Diana
D
Imhof
Department of Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Str. 2, D-07745 Jena, Germany.
Stefan H
SH
Heinemann
Clemens-Schöpf-Institute of Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Alarich-Weiss-Str. 4, D-64287 Darmstadt, Germany. Electronic address: a.tietze@biochemie-tud.de.
Alesia A
AA
Tietze
D001665:Binding Sites; D002460:Cell Line; D020916:Conotoxins / Q000737:chemistry* / Q000378:metabolism*; D000939:Epitopes / Q000737:chemistry / Q000378:metabolism; D057809:HEK293 Cells; D006801:Humans; D061566:Voltage-Gated Sodium Channels / Q000737:chemistry* / Q000378:metabolism*
D020916:Conotoxins; D000939:Epitopes; D061566:Voltage-Gated Sodium Channels
Conotoxin; Molecular dynamics simulations; NMR structural analysis; Voltage-sensor toxin; δ-EVIA