Toxic Epidermal Necrolysis Induced by the Topical Carbonic Anhydrase Inhibitors Brinzolamide and Dorzolamide.
Brinzolamide and dorzolamide are highly specific topical carbonic anhydrase inhibitors (CAIs). They lower intraocular pressure (IOP) by reducing the rate of aqueous humour formation without serious side effects. Although systemic CAIs are the most potent medications for lowering intraocular pressure for conditions with ocular hypertension, many cases with adverse systemic reactions have been reported, including Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN). Here, we report 2 cases of TEN that were associated with topical CAIs rather than systemic CAIs.
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
Ji Sun
JS
Chun
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
Sook Jung
0000-0003-4229-5831
SJ
Yun
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
Jee Bum
JB
Lee
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
Seong Jin
SJ
Kim
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
Young Ho
YH
Won
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
Seung Chul
SC
Lee
Brinzolamide; Dorzolamide; Toxic epidermal necrolysis