Overexpression of IL-18 in the Proliferative Phase Endometrium of Patients With Polycystic Ovary Syndrome.
Women with polycystic ovary syndrome (PCOS) exhibit low implantation rate and high abortion rate. To explore the effect of low-grade chronic inflammation on endometrium of women with PCOS, we investigated the expression of interleukin 18 (IL-18) in the endometrium of 23 women with PCOS and 20 healthy women. Endometrial tissue samples were obtained during hysteroscopic surgery. We found that IL-18 was significantly increased in the endometrium of women with PCOS compared with normal groups. In overweight women, IL-18 was obviously overexpressed in the PCOS group compared to the healthy group. However, in normal-weight women, there was no statistically significant difference between the 2 groups, and there was no significant difference in IL-18 expression in patients having PCOS with or without insulin resistance. We conclude that IL-18 protein and messenger RNA levels are increased in the endometrium of patients with PCOS, and this effect is correlated with body mass index.
1 Department of Obstetrics and Gynecology, Reproductive Medical Center, Peking University Third Hospital, Beijing, China.|2 Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China.|3 Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
Xiaoyu
X
Long
1 Department of Obstetrics and Gynecology, Reproductive Medical Center, Peking University Third Hospital, Beijing, China.|2 Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China.|3 Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
Rong
R
Li
1 Department of Obstetrics and Gynecology, Reproductive Medical Center, Peking University Third Hospital, Beijing, China.|2 Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China.|3 Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
Yan
Y
Yang
1 Department of Obstetrics and Gynecology, Reproductive Medical Center, Peking University Third Hospital, Beijing, China.|2 Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, China.|3 Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
Jie
J
Qiao
D000328:Adult; D015992:Body Mass Index; D049109:Cell Proliferation; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000378:metabolism*; D050177:Overweight / Q000150:complications / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000378:metabolism*; D055815:Young Adult
D020382:Interleukin-18
IL-18; endometrium; polycystic ovarian syndrome