Polycomb and lung cancer: When the dosage makes the (kind of) poison.
The Polycomb transcriptional repressors regulate normal tissue homeostasis and their function is often hijacked during oncogenesis. We recently uncovered the Polycomb repressive complex-2 (PRC2) genes Ezh2 and Eed as oncogenotype-dependent cancer genes. Notably, within the same oncogenotype, PRC2 dosage modulates lung tumor homeostasis and critically impacts non-tumor tissue function.
Division of Molecular Genetics, The Netherlands Cancer Institute , Amsterdam, The Netherlands.
Gaetano
G
Gargiulo
Division of Molecular Genetics, The Netherlands Cancer Institute , Amsterdam, The Netherlands.
Elisabetta
E
Citterio
Division of Molecular Genetics, The Netherlands Cancer Institute , Amsterdam, The Netherlands.
Michela
M
Serresi
Epigenetics; Ezh2; Kras; Lung Cancer; Polycomb; inflammation; p53