The relationship between rosacea and insulin resistance and metabolic syndrome.
Rosacea is a chronic inflammatory skin disease affecting the face. A positive correlation has been found between rosacea and cardiovascular diseases. We sought to investigate the relation between rosacea and metabolic syndrome (MS) and insulin resistance (IR). Between January and June 2015, a case-control study including 47 age-, gender-, and body mass index (BMI)-matched rosacea patients and 50 controls was conducted. Demographic data, clinical features of rosacea patients, anthropometric measures, laboratory findings, blood pressure levels, BMI, smoking history, alcohol consumption, sports life, family history of cardiovascular disease, and presence of MS and IR were recorded. Forty-seven rosacea patients (12 men and 35 women; age range: 35-68 years) and 50 controls (11 men and 39 women; age range: 38-78 years) were included in our study. Of 47 rosacea patients, 24 had erythematotelangiectatic type, 22 had papulopustular type, and one had phymatous type. Whereas the rate of IR was significantly higher in the rosacea group, there was no significant difference in the rate of MS between rosacea and the control group (p = 0.009 and p = 0.186, respectively). In addition, the rosacea group had significantly higher fasting blood glucose, total cholesterol, and systolic and diastolic blood pressure levels (p<0.05). Mean levels of LDL, triglyceride, total cholesterol and CRP were significantly higher than in the control group (p<0.05). Our findings suggest that there is a relationship between rosacea and IR and some parameters of cardiovascular risk factors. We recommend investigation of IR in rosacea patients.
Department of Dermatology, Kocman University Training and Research Hospital, Mugla.
Asli
A
Akin Belli
Department of Dermatology, Artvin Hopa State Hospital, Artvin.
Seyran
S
Ozbas Gok
Department of Endocrinology and Metabolism Diseases, Mugla Sitki Kocman University Training and Research Hospital, Mugla.
Gulhan
G
Akbaba
Ardahan State Hospital, Department of Dermatology, Ardahan, Turkey.
Fatma
F
Etgu
Department of Dermatology, Kocman University Training and Research Hospital, Mugla.
Gursoy
G
Dogan
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D012393:Rosacea / Q000453:epidemiology* / Q000503:physiopathology*; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008078:Cholesterol, LDL; D014280:Triglycerides; D002097:C-Reactive Protein
cardiovascular diseases; insulin resistance; metabolic syndrome; rosacea