Multicomponent synthesis of diverse pyrano-fused benzophenazines using bifunctional thiourea-based organocatalyst in aqueous medium.
A series of pyrano-fused benzophenazines were synthesized using a bifunctional thiourea-based organocatalyst from the one-pot four-component reaction of 2-hydroxy-1,4-naphthoquinone, benzene-1,2-diamines, malononitrile or its derivatives and isatins or aromatic aldehydes in aqueous medium. Metal-free reaction condition, water as solvent, high bond forming efficiency (five new bonds formed in one step), good yields and easy purification process are the notable features of this methodology.
Department of Chemistry, National Institute of Technology Patna, Ashok Rajpath, Patna, 800005, India.
Ruchi
R
Bharti
Department of Chemistry, National Institute of Technology Patna, Ashok Rajpath, Patna, 800005, India. tasneem@nitp.ac.in.
Tasneem
T
Parvin
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010619:Phenazines / Q000138:chemical synthesis* / Q000737:chemistry; D011714:Pyrans / Q000737:chemistry*; D012997:Solvents; D013890:Thiourea / Q000737:chemistry*
D010619:Phenazines; D011714:Pyrans; D012997:Solvents; D013890:Thiourea
Aqueous medium; MCRs; Multicomponent reactions; Pyrano-fused benzophenazines; Thiourea-based organocatalysts