Future Directions for Surgical Trial Designs in Trigeminal Neuralgia.
Should patients undergo surgical intervention as soon as they receive a diagnosis of trigeminal neuralgia (TN), or should they wait until pharmacologic treatment fails? This article describes some of the challenges encountered in surgical trials for TN, and provides some guidance for future trials in this area. One future direction for TN research is to use the innovative "cohort multiple RCT design," This article describes some of the challenges encountered in surgical trials for TN, and provides some guidance for future trials in this area. One future direction for TN research is to use the innovative "cohort multiple RCT design," which enables multiple trials to be embedded within a single cohort of patients with TN diagnosis, providing an efficient and effective approach to the testing of multiple interventions for TN with each other and with usual care.
Division of Diagnostic, Surgical and Medical Sciences, Eastman Dental Hospital, UCLH NHS Foundation Trust, 256 Gray's Inn Road, London WC1X 8LD, UK. Electronic address: j.zakrzewska@ucl.ac.uk.
Joanna M
JM
Zakrzewska
School for Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield S1 4DA, UK.
Clare
C
Relton
D002986:Clinical Trials as Topic; D006801:Humans; D019635:Neurosurgical Procedures / Q000639:trends*; D012107:Research Design / Q000639:trends*; D014276:Trigeminal Nerve / Q000601:surgery*; D014277:Trigeminal Neuralgia / Q000601:surgery*
Cohort multiple RCT design; Randomized controlled trial; Research; Surgery; TN; Trial design