Metformin as a Tool to Target Aging.
Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.
Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: nir.barzilai@einstein.yu.edu.
Nir
N
Barzilai
Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Jill P
JP
Crandall
Wake Forest Older Americans Independence Center and the Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Stephen B
SB
Kritchevsky
Wake Forest Older Americans Independence Center and the Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Mark A
MA
Espeland
D000375:Aging / Q000187:drug effects* / Q000502:physiology*; D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D008136:Longevity / Q000187:drug effects; D008687:Metformin / Q000494:pharmacology*; D023421:Models, Animal; D008954:Models, Biological
D008687:Metformin