PTP1B: mediating ROS signaling to silence genes.
Numerous studies have shown that normal cells often respond to the activation of oncogenes by undergoing reactive oxygen species-dependent induction of senescence. Here, we discuss our recent publication identifying protein tyrosine phosphatase PTP1B as an important redox-controlled checkpoint for senescence downstream of oncogenic RAS.
Department of Biochemistry and Department of Medicine; Université de Montréal; Montréal, QC Canada; Montreal Heart Institute; Montréal, QC Canada.
Benoit
B
Boivin
Cold Spring Harbor Laboratory ; Cold Spring Harbor; NY USA.
Nicholas K
NK
Tonks
PTP1B; argonaute; cancer; gene silencing; microRNAs; oncogene; p21; phosphatase; reactive oxygen species; senescence