Association between sedentary time and kidney function in community-dwelling elderly Japanese people.
OBJECTIVE
The aim of the present study was to evaluate the relationship between sedentary time and declines in kidney function among community-dwelling older adults.


METHODS
Participants comprised 10 242 community-dwelling older adults who were participating in the National Center for Geriatrics and Gerontology - Study of Geriatric Syndromes. Sedentary time was determined by asking participants to record the total amount of hours usually spent sitting each day, with values divided into quartiles of 0 to <4 h (reference), 4 to <6 h, 6 to <8 h and ≥8 h of sitting time per day. The estimated glomerular filtration rate was determined according to creatinine levels, and participants were classified into two categories: ≥60.0 or <60 mL/min/1.73 m2.


RESULTS
After multivariate adjustment, the highest quartiles of sedentary time showed a higher rate of kidney function decline than those in the lowest quartile (odds ratio 1.42, 95% CI 1.02-1.37). In addition, participants with a history of cancer (odds ratio 1.18, 95% CI 1.01-1.39) or hypertension (odds ratio 1.38; 95% CI 1.07-1.60) had significantly increased risks of kidney function decline in the highest sedentary time group, regardless of multivariate control. Furthermore, analyses showed an increased risk of kidney function decline for a history of both cancer and hypertension (odds ratio 2.02, 95% CI 1.08-3.80).


CONCLUSIONS
A higher level of sedentary time was associated with kidney function decline among community-dwelling older adults. Geriatr Gerontol Int 2017; 17: 730-736.
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
Sungchul
S
Lee
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
Hiroyuki
H
Shimada
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
Sangyoon
S
Lee
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
Hyuma
H
Makizako
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.|Japan Society for the Promotion of Science, Tokyo, Japan.
Takehiko
T
Doi
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
Kazuhiro
K
Harada
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
Seongryu
S
Bae
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
Kenji
K
Harada
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
Ryo
R
Hotta
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
Kota
K
Tsutsumimoto
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.|Department of Physical Therapy, Faculty of Rehabilitation, Kyusyu Nutrition Welfare University, Kyusyu, Japan.
Daisuke
D
Yoshida
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
Sho
S
Nakakubo
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.|Department of Nutritional Health, Kyusyu Nutrition Welfare University, Kawasaki, Japan.
Yuya
Y
Anan
Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.|Department of Health Care and Science, Dong-A University, Busan, Korea.
Hyuntae
H
Park
Institute for Aging and Development, J.F. Oberlin University, Tokyo, Japan.
Takao
T
Suzuki
D000368:Aged; D003404:Creatinine / Q000097:blood*; D005260:Female; D015577:Geriatric Assessment / Q000379:methods*; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D057187:Independent Living / Q000706:statistics & numerical data*; D007564:Japan / Q000453:epidemiology; D007677:Kidney Function Tests; D008297:Male; D009017:Morbidity / Q000639:trends; D016017:Odds Ratio; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D057185:Sedentary Behavior; D057566:Self Report; D012720:Severity of Illness Index; D017678:Sex Distribution
D003404:Creatinine
creatinine; estimated glomerular filtration rate; kidney function; older adults; sedentary time