The Protective Role of Dexpanthenol on the Endometrial Implants in an Experimentally Induced Rat Endometriosis Model.
Dexpanthenol (Dxp), antioxidant and anti-inflammatory agent, plays an important role in the repair systems against oxidative stress and inflammatory response. The objective of this study is to determine the effect of Dxp on experimental endometriosis model.



A prospective experimental study was conducted in Experimental Animal Laboratory of Mustafa Kemal University, Hatay. Twenty nonpregnant female Wistar albino rats, in which experimental model of endometriosis was surgically induced, were randomly divided into 2 groups. Group 1 was administered 500 mg/kg/d Dxp intraperitoneally for 14 days, and group 2 was given the same amount of saline solution. After 2 weeks of medication, the rats were killed and implant volumes, histopathologic scores; and levels of serum total antioxidant status, total oxidant status (TOS), and oxidative stress index (OSI) were evaluated. Plasma and peritoneal fluid levels of tumor necrosis factor α (TNF-α) were analyzed.



The endometriotic implant volumes, histopathologic scores, and serum TOS and OSI values were significantly decreased ( P < .05) in the Dxp group compared to the control group. Plasma and peritoneal fluid TNF-α levels were significantly decreased ( P < .05) in the Dxp group compared to the control group.



Dexpanthenol has free radical scavenger effects, and antioxidant properties has significantly regressed endometriotic implant volumes, histopathologic scores, and serum TOS and OSI values. Serum and peritoneal fluid TNF-α levels were significantly decreased in the Dxp group. So Dxp decreased oxidative stress.
1 Department of Obstetrics and Gynaecology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Oya
O
Soylu Karapinar
2 Department of Medical Pharmacology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Neslihan
N
Pinar
3 Department of Pathology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Tümay
T
Özgür
4 Department of Biochemistry, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Oğuzhan
O
Özcan
5 Department of Medical Microbiology, Faculty of Medicine, Çukurova University, Adana, Turkey.
H Suphi
HS
Bayraktar
1 Department of Obstetrics and Gynaecology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Raziye Keskin
RK
Kurt
1 Department of Obstetrics and Gynaecology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Orhan
O
Nural
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001202:Ascitic Fluid / Q000378:metabolism; D004195:Disease Models, Animal; D004715:Endometriosis / Q000378:metabolism*; D005260:Female; D007249:Inflammation / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D020011:Protective Agents; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha; D010205:Pantothenic Acid; C007288:dexpanthenol
dexpanthenol; endometriosis; oxidative stress