Mitochondria Apply the Brake to Viral Immunity.
The development and function of cytotoxic CD8 T cells (CTLs), which provide immunity to viral infections, are regulated by changes in mitochondrial respiration. Champagne et al. (2016) describe a new mechanism through which mitochondrial metabolism controls production of ATP required for the secretion of critical anti-viral molecules by CTLs.
Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK. Electronic address: p.ashton-rickardt@imperial.ac.uk.
Philip G
PG
Ashton-Rickardt
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007109:Immunity; D051379:Mice; D008928:Mitochondria / Q000276:immunology*; D008954:Models, Biological; D014777:Virus Diseases / Q000276:immunology*
D000255:Adenosine Triphosphate