Lyotropic behavior of Gelucire 50/13 by XRD, Raman and IR spectroscopies according to hydration.
The present paper discuss the structural and vibrational properties of polyoxyethylene glycol glycerides (Gelucire 50/13) during the hydration with increasing water from 0% to 80%. The Gelucire 50/13 used as sustained release matrix forming agent in pharmaceutical applications and it was essentially studied by Small and Wide Angle X-ray Scattering (SWAXS), Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy according to the rate of hydration. The hydration behavior of this amphiphilic excipient has been investigated in the spectral range 4000-0cm-1in Raman spectroscopy, and 4000-600cm-1in FTIR. At increasing water contents Gelucire 50/13 forms successive bicontinuous to micellar supramolecular structures, and the vibrational changes were directly correlated with this conformational changes of the Gelucire structure. Overall, Raman and IR spectroscopy clearly demonstrated that the different functional groups studied could be characterized independently, allowing for the understanding of their role in Gelucire polymorphism.
Laboratoire de Physique de la Matière Condensée, Université Abdelmalek Essaâdi, Tétouan, Morocco.
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El Hadri
Laboratoire de Physique de la Matière Condensée, Université Abdelmalek Essaâdi, Tétouan, Morocco.
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Achahbar
Laboratoire de Physique de la Matière Condensée, Université Abdelmalek Essaâdi, Tétouan, Morocco.
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El Khamkhami
Faculté des sciences, Université d'Artois, Lens, France; Laboratoire de Physique des Systèmes Complexes, Université Picardie Jules Verne, 33 rue St. Leu, 80039 Amiens cedex, France.
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Khelifa
Equipe Physico-chimie des Systèmes Polyphasés, UMR CNRS 8612, Labex LERMIT Université Paris Sud, France.
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Faivre
Walloon Agricultural Research Centre (CRA-W), Valorisation of Agricultural Products, Department, Food and Feed Quality Unit (U15), 'Henseval Building', Chaussée de Namur 24, 5030 Gembloux, Belgium.
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Abbas
Laboratoire de Physique des Systèmes Complexes, Université Picardie Jules Verne, 33 rue St. Leu, 80039 Amiens cedex, France. Electronic address: sergebresson@yahoo.fr.
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Bresson
D005223:Fats / Q000138:chemical synthesis / Q000737:chemistry*; D009821:Oils / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D005223:Fats; D009821:Oils; D014867:Water; C071184:Gelucire 50-13
ATR FTIR; Gelucire 50/13; Hydration; PEG; Spectroscopy Raman; Triglycerides