Curcumin in Treating Breast Cancer: A Review.
Breast cancer is among the most common malignant tumors. It is the second leading cause of cancer mortality among women in the United States. Curcumin, an active derivative from turmeric, has been reported to have anticancer and chemoprevention effects on breast cancer. Curcumin exerts its anticancer effect through a complicated molecular signaling network, involving proliferation, estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) pathways. Experimental evidence has shown that curcumin also regulates apoptosis and cell phase-related genes and microRNA in breast cancer cells. Herein, we review the recent research efforts in understanding the molecular targets and anticancer mechanisms of curcumin in breast cancer.
School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University, Shanghai, China.|School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yiwei
Y
Wang
School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jiayi
J
Yu
School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Ran
R
Cui
School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jinjin
J
Lin
School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University, Shanghai, China dingxianting@gmail.com.
Xianting
X
Ding
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001688:Biological Products / Q000494:pharmacology* / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D003474:Curcumin / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects; D014481:United States
D000970:Antineoplastic Agents; D001688:Biological Products; D003474:Curcumin
breast cancer; curcumin; natural compound; signaling pathways