TRAMM, a new player in CENP-E biology.
Mitosis is a highly orchestrated process with morphologically defined stages and is subject to checkpoints that ensure the proper distribution of chromosomes. Centromere-associated protein E (CENP-E), a protein expressed during mitosis, is a potential target of cancer therapeutics. Our laboratory has recently implicated a protein called TRAMM (trafficking of membranes and mitosis) in the recruitment of CENP-E to kinetochores.
Concordia University, Department of Biology , Montreal, Quebec, Canada.
Miroslav P
MP
Milev
Concordia University, Department of Biology, Montreal, Quebec, Canada; McGill University, Department of Anatomy and Cell Biology, Montreal, Quebec, Canada.
Michael
M
Sacher
CENP-E; TRAMM; TRAPP; chromosome congression; mitosis