The dynamic changes of DNA methylation in primordial germ cell differentiation.
The discovery of DNA methylation has provided a new perspective on how DNA may be dynamically regulated in the mammalian genome. DNA methylation is a dynamic process with a demethylation and de novo methylation from primordial germ cell to differentiation. DNA methylation and demethylation have been proposed to play important roles in somatic cell reprogramming. Some essential components were discussed, such as hydroxymethylation which has recently been confirmed as a modification of developmental importance.
Department of Cardiology, Guang' an men Hospital, China Academy of Chinese Medical Science, No.5 Bei xiange, Xicheng District, Beijing, China; Graduate School, Beijing University of Traditional Chinese Medicine, No.11 North Third Ring Road, Chaoyang District, Beijing, China.
Lian
L
Duan
Department of Cardiology, Guang' an men Hospital, China Academy of Chinese Medical Science, No.5 Bei xiange, Xicheng District, Beijing, China.
Yongmei
Y
Liu
Department of Cardiology, Guang' an men Hospital, China Academy of Chinese Medical Science, No.5 Bei xiange, Xicheng District, Beijing, China. Electronic address: wangjiedoctor2015@163.com.
Jie
J
Wang
Department of Cardiology, Guang' an men Hospital, China Academy of Chinese Medical Science, No.5 Bei xiange, Xicheng District, Beijing, China; Graduate School, Beijing University of Traditional Chinese Medicine, No.11 North Third Ring Road, Chaoyang District, Beijing, China.
Jiangquan
J
Liao
Department of Cardiology, Guang' an men Hospital, China Academy of Chinese Medical Science, No.5 Bei xiange, Xicheng District, Beijing, China; Graduate School, Beijing University of Traditional Chinese Medicine, No.11 North Third Ring Road, Chaoyang District, Beijing, China.
Junyuan
J
Hu
D000818:Animals; D019175:DNA Methylation; D005718:Gametogenesis / Q000235:genetics*; D005854:Germ Cells / Q000166:cytology*; D006801:Humans
CpG island; DNA methylation; Hydroxymethylation; TET