The recent development of nanoparticles for brain tumor targeting delivery.
Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted a lot of interest due to their widespread diagnostic and therapeutic applications in neuro-oncology. Functinalization of the particles surface with targeting molecules that recognize tumor receptors might be exploited for the specific brain tumor targeting. Furthermore, multifunctional and/or theranostic SPIONs can be used for simultaneous imaging of cancer and anti-tumor drug delivery. In this review article, we will specifically focus on the application of focused ultrasound and external magnetic field for the facilitation of the intratumoral accumulation of particles.
Institute of Cytology (RAS), St.Petersburg, 194064 Tikhoretsky ave., 4. Russia. maxim.shevtsov@tum.de.
Maxim A
MA
Shevtsov