ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men.
Associations between alcohol consumption and type 2 diabetes risk are inconsistent in epidemiologic studies. This study investigated the associations of ADH1B and ALDH2 polymorphisms with fasting blood glucose levels, and the impact of the associations of alcohol consumption with fasting blood glucose levels in Japanese individuals. This cross-sectional study included 907 men and 912 women, aged 35-69 years. The subjects were selected from among the Japan Multi-institutional Collaborative Cohort study across six areas of Japan. The ADH1B and ALDH2 polymorphisms were genotyped by Invader Assays. The ALDH2 Glu504Lys genotypes were associated with different levels of fasting blood glucose in men (P = 0.04). Mean fasting glucose level was positively associated with alcohol consumption in men with the ALDH2 504 Lys allele (P trend = 0.02), but not in men with the ALDH2 504Glu/Glu genotype (P trend = 0.45), resulting in no statistically significant interaction (P = 0.38). Alcohol consumption was associated with elevated fasting blood glucose levels compared with non-consumers in men (P trend = 0.002). The ADH1B Arg48His polymorphism was not associated with FBG levels overall or after stratification for alcohol consumption. These findings suggest that the ALDH2 polymorphism is associated with different levels of fasting blood glucose through alcohol consumption in Japanese men. The interaction of ALDH2 polymorphisms in the association between alcohol consumption and fasting blood glucose warrants further investigation.
Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Guang
G
Yin
Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Mariko
M
Naito
Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kenji
K
Wakai
Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Emi
E
Morita
Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Sayo
S
Kawai
Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nobuyuki
N
Hamajima
Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Sadao
S
Suzuki
Department of Health Science, Shiga University of Medical Science, Otsu, Japan.
Yoshikuni
Y
Kita
Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan.
Toshiro
T
Takezaki
Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Keitaro
K
Tanaka
Department of Preventive Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Makiko
M
Morita
Department of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan.
Hirokazu
H
Uemura
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Etsuko
E
Ozaki
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Satoyo
S
Hosono
Division of Cancer Registry, Prevention and Epidemiology, Chiba Cancer Center, Chiba, Japan.
Haruo
H
Mikami
Laboratory for Genotyping Development, Center for Genomic Medicine, RIKEN, Yokohama, Japan.
Michiaki
M
Kubo
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Hideo
H
Tanaka
D000328:Adult; D000368:Aged; D000426:Alcohol Dehydrogenase; D000428:Alcohol Drinking; D000071396:Aldehyde Dehydrogenase, Mitochondrial / Q000235:genetics*; D001786:Blood Glucose; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2; D005215:Fasting; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D001786:Blood Glucose; C489332:ADH1B protein, human; D000426:Alcohol Dehydrogenase; C096127:ALDH2 protein, human; D000071396:Aldehyde Dehydrogenase, Mitochondrial
ADH1B and ALDH2 polymorphisms; alcohol consumption; fasting blood glucose; type 2 diabetes