Dynamics of the membrane-cytoskeleton interface in MHC class II-restricted antigen presentation.
Antigen presentation refers to the ability of cells to show MHC-associated determinants to T lymphocytes, leading to their activation. MHC class II molecules mainly present peptide-derived antigens that are internalized by endocytosis in antigen-presenting cells (APCs). Here, we describe how the interface between cellular membranes and the cytoskeleton regulates the various steps that lead to the presentation of exogenous antigens on MHC class II molecules in the two main types of APCs: dendritic cells (DCs) and B lymphocytes. This includes antigen uptake, processing, APC migration, and APC-T cell interactions. We further discuss how the interaction between APC-specific molecules and cytoskeleton elements allows the coordination of antigen presentation and cell migration in time and space.
Inserm U932, Institut Curie, ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043, Paris, France.
Marine
M
Bretou
Inserm U932, Institut Curie, ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043, Paris, France.
Anita
A
Kumari
Inserm U932, Institut Curie, ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043, Paris, France.
Odile
O
Malbec
Inserm U932, Institut Curie, ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043, Paris, France.
Hélène D
HD
Moreau
Inserm U932, Institut Curie, ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043, Paris, France.
Dorian
D
Obino
Inserm U932, Institut Curie, ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043, Paris, France.
Paolo
P
Pierobon
Inserm U932, Institut Curie, ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043, Paris, France.
Violaine
V
Randrian
Inserm U932, Institut Curie, ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043, Paris, France.
Pablo J
PJ
Sáez
Inserm U932, Institut Curie, ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043, Paris, France.
Ana-Maria
AM
Lennon-Duménil
D000818:Animals; D017951:Antigen Presentation; D000941:Antigens / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology*; D002462:Cell Membrane / Q000378:metabolism*; D002465:Cell Movement; D003599:Cytoskeleton / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology*; D004705:Endocytosis; D006649:Histocompatibility Antigens / Q000378:metabolism; D006801:Humans; D054992:Immunological Synapses; D008213:Lymphocyte Activation; D010455:Peptides / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D006649:Histocompatibility Antigens; D010455:Peptides
B lymphocyte; antigen presentation; cell polarity; cytoskeleton; dendritic cell; membrane trafficking