[THE SPECTRUM OF RENAL DISEASE IN KIDNEY BIOPSIES OF DIABETIC PATIENTS: A SINGLE CENTER EXPERIENCE].
BACKGROUND
Kidney biopsies are not routinely performed for diabetic patients with chronic kidney disease. However in some cases, a biopsy is carried out to exclude other treatable Prolonged duration of diabetes, insulin therapies and presence of diabetic retinopathy were associated with a greater likelihood of DN. The high prevalence of NDRD in our population emphasizes the judicious use of kidney biopsy in diabetic patients. e renal diseases. The prevalence and the nature of non diabetic renal disease (NDRD) among diabetic patients in Israel have not yet been evaluated.


OBJECTIVE
To assess pathological findings of kidney biopsies conducted in patients with diabetes mellitus.


METHODS
A total of 200 native kidney biopsies were performed during the study period. Patients who had a diagnosis of diabetes mellitus were included in the study. Clinical data and pathological findings were retrospectively collected and analyzed.


RESULTS
The cohort included 34 patients, median age 61.8 years. The male to female ratio was 25:9; mean serum creatinine was 1.8 ± 1.2 mg/dl The duration of diabetes was significantly shorter in patients with NDRD (6.8 ± 7.1 years vs. 13.0 ± 9.6 years in diabetic nephropathy (DN) or combined), whereas insulin therapy was significantly more common in patients with DN (72% vs 5% in NDRD). Diabetic retinopathy was documented in 57% of patients with diabetic nephropathy but wasn't documented in any patient with NDRD. Prevalence of NDRD, DN and combined pathology was 58.8%, 32.4% and 8.8% respectively. Neither the level of proteinuria nor the rate of renal function deterioration could predict pathological findings in the biopsy. The most common NDRD disease was nephrosclerosis.


CONCLUSIONS
Non-diabetic renal disease was common. Prolonged duration of diabetes, insulin therapies and presence of diabetic retinopathy were associated with a greater likelihood of DN. The high prevalence of NDRD in our population emphasizes the judicious use of kidney biopsy in diabetic patients.
Yael
Y
Einbinder
Debbie J
DJ
Goodman
Isabelle
I
Haggiag
Tania
T
Zahavi
Sydney
S
Benchetrit
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D003930:Diabetic Retinopathy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D007557:Israel; D007674:Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009400:Nephrosclerosis / Q000175:diagnosis / Q000453:epidemiology; D015995:Prevalence; D011507:Proteinuria / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
D007328:Insulin