An Efficient Synthesis of (±)-Hasakol, a Bioactive Coumarin from Citrus hassaku.
Hasakol, a new antispasmodic coumarin isolated from Citrus hassaku, was synthesized from 7-geranyloxycoumarin by an improved method. This synthesis involves only 3 steps and results in a yield 27% based on the starting material.
a Faculty of Human Life Science, Osaka City University, Sumiyoshi , Osaka 558 , Japan.
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Masuda
a Faculty of Human Life Science, Osaka City University, Sumiyoshi , Osaka 558 , Japan.
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Kawai
Citrus hassaku; antispasmodic activity; coumarin; hasakol; synthesis