Innate Immunity: ER Stress Recruits NOD1 and NOD2 for Delivery of Inflammation.
NOD1 and NOD2, two members of the intracellular NOD-like receptor family, sense bacterial peptidoglycan-derived fragments and induce pro-inflammatory responses. Recent work provides evidence for a role for NOD1/NOD2 signaling in mediating ER-stress-induced inflammatory responses via a peptidoglycan-independent mechanism.
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Roberta
R
Caruso
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: gabriel.nunez@umich.edu.
Gabriel
G
Núñez
D002003:Brucella abortus; D059865:Endoplasmic Reticulum Stress; D007113:Immunity, Innate; D007249:Inflammation / Q000378:metabolism*; D053474:Nod1 Signaling Adaptor Protein / Q000378:metabolism*; D053473:Nod2 Signaling Adaptor Protein / Q000378:metabolism*
D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein