Taspase 1: A protease with many biological surprises.
Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to orchestrate various biological processes. TASP1 is not a classical oncogene, but assists in cell proliferation and permits oncogenic initiation through cleavage of MLL and TFIIA. TASP1 is thus better classified as a "non-oncogene addiction" protease, and targeting TASP1 offers a novel and attractive anticancer therapeutic strategy.
Human Oncology & Pathogenesis Program; Memorial Sloan-Kettering Cancer Center; New York, NY, USA; Department of Pediatrics; Tohoku University Graduate School of Medicine; Sendai, Miyagi, Japan.
Hidetaka
H
Niizuma
Human Oncology & Pathogenesis Program; Memorial Sloan-Kettering Cancer Center; New York, NY, USA; Department of Pathology; Memorial Sloan-Kettering Cancer Center; New York, NY, USA.
Emily H
EH
Cheng
Human Oncology & Pathogenesis Program; Memorial Sloan-Kettering Cancer Center; New York, NY, USA; Department of Medicine; Memorial Sloan-Kettering Cancer Center; New York, NY, USA; Department of Medicine; Weill Medical College of Cornell University; New York, NY, USA.
James J
JJ
Hsieh
CDK inhibitor; MLL; TFIIA; Taspase 1; cyclin