Carvacrol Exerts Neuroprotective Effects Via Suppression of the Inflammatory Response in Middle Cerebral Artery Occlusion Rats.
Increasing evidence demonstrates that inflammation plays an important role in cerebral ischemia. Carvacrol, a monoterpenic phenol, is naturally occurring in various plants belonging to the family Lamiaceae and exerts protective effects in a mice model of focal cerebral ischemia/reperfusion injury by reducing infarct volume and decreasing the expression of cleaved caspase-3. However, the anti-inflammatory mechanisms by which carvacrol protect the brain have yet to be fully elucidated. We investigated the effects of carvacrol on inflammatory reaction and inflammatory mediators in middle cerebral artery occlusion rats. The results of the present study showed that carvacrol inhibited the levels of inflammatory cytokines and myeloperoxidase (MPO) activity, as well as the expression of iNOS and COX-2. It also increased SOD activity and decreased MDA level in ischemic cortical tissues. In addition, carvacrol treatment suppressed the ischemia/reperfusion-induced increase in the protein expression of nuclear NF-kB p65. In conclusion, we have shown that carvacrol inhibits the inflammatory response via inhibition of the NF-kB signaling pathway in a rat model of focal cerebral ischemia. Therefore, carvacrol may be a potential therapeutic agent for the treatment of cerebral ischemia injury.
Department of Rehabilitation, The First Hospital of Jilin University, Xinmin Street No.71, Changchun, 130021, Jilin, China.
Zhenlan
Z
Li
Department of Neurosurgery, The First Hospital of Jilin University, Xinmin Street No.71, Changchun, 130021, Jilin, China.
Cong
C
Hua
Department of Neurosurgery, The First Hospital of Jilin University, Xinmin Street No.71, Changchun, 130021, Jilin, China.
Xiaoqiang
X
Pan
Department of Neurology, The First Hospital of Jilin University, Xinmin Street No.71, Changchun, 130021, Jilin, China.
Xijia
X
Fu
Department of Neurosurgery, The First Hospital of Jilin University, Xinmin Street No.71, Changchun, 130021, Jilin, China. wweijilin@sina.com.
Wei
W
Wu
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy; D000081007:Cymenes; D020244:Infarction, Middle Cerebral Artery / Q000378:metabolism* / Q000473:pathology; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D039821:Monoterpenes / Q000494:pharmacology*; D016328:NF-kappa B / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology; D051381:Rats; D015427:Reperfusion Injury / Q000188:drug therapy; D015398:Signal Transduction / Q000187:drug effects
D000081007:Cymenes; D039821:Monoterpenes; D016328:NF-kappa B; D018696:Neuroprotective Agents; C073316:carvacrol
carvacrol; inflammatory response; ischemic stroke