Disrupting the dynamic equilibrium of ORAI channels determines the phenotype of malignant cells.
We recently unraveled a finely tuned oncogenic mechanism in which genetic and tumor microenvironment alterations act together on a crucial calcium signaling pathway. This pathway involves an interconnected equilibrium of calcium channels functioning like a binary star system in which ORAI1 homomers and ORAI1/3 heteromers are two companion stars under the influence of each other that orbit around the cancer hallmarks of apoptosis resistance and enhanced proliferation.
Inserm U1003; Equipe labellisée par la Ligue Nationale Contre le Cancer; SIRIC ONCOLille; Laboratory of Excellence; Ion Channels Science and Therapeutics; Université des Sciences et Technologies de Lille (USTL) ; Villeneuve d'Ascq, France.
Fabien
F
Vanden Abeele
Inserm U1003; Equipe labellisée par la Ligue Nationale Contre le Cancer; SIRIC ONCOLille; Laboratory of Excellence; Ion Channels Science and Therapeutics; Université des Sciences et Technologies de Lille (USTL) ; Villeneuve d'Ascq, France.
Charlotte
C
Dubois
Bogomoletz Institute of Physiology and International Center of Molecular Physiology of the National Academy of Sciences of Ukraine; State Key Laboratory ; Kiev, Ukraine.
Yaroslav
Y
Shuba
Inserm U1003; Equipe labellisée par la Ligue Nationale Contre le Cancer; SIRIC ONCOLille; Laboratory of Excellence; Ion Channels Science and Therapeutics; Université des Sciences et Technologies de Lille (USTL) ; Villeneuve d'Ascq, France.
Natalia
N
Prevarskaya