[NEW ASPECTS OF TRANSENDOSCOPIC TREATMENT OF PEPTIC ULCER ASSOCIATED WITH DYSBACTERIOSIS OF GASTRODUODENAL ZONE].
OBJECTIVE
Find out the condition of mucosal microflora in gastroduodenal ulcer patients in different phases of its recurrence, to determine changes in the value of dysbiotic changes in ulcerogenesis, develop and confirm new transendoscopic treatment of gastroduodenal ulcers.


METHODS
The study included 134 patients and 10 healthy volunteers


RESULTS
At relapse of peptic ulcer and distant from the ulcer areas of the mucosa were allocated to 28 genera and species of microorganisms with a wide range of enzymatic activity and cytotoxicity, that corresponds to the 2-3 degree dysbacteriosis and shows microbiological parameters infected wound which required sanation.


CONCLUSIONS
Application for transendoscopic sanation of gastroduodenal ulcers of new compounds iodine-lysozyme, dimexide-iodine-lysozyme and chitosan with bactericidal and sorption effects, can significantly reduce the time of ulcer healing and restore normobiocenosis of mucosal microflora of the gastroduodenal zone.
S N
SN
Bazlov
V V
VV
Chernin
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D048271:Chitosan / Q000008:administration & dosage / Q000627:therapeutic use; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000627:therapeutic use; D016503:Drug Delivery Systems; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005753:Gastric Mucosa / Q000187:drug effects / Q000382:microbiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000382:microbiology*; D007454:Iodides / Q000008:administration & dosage / Q000627:therapeutic use; D009113:Muramidase / Q000008:administration & dosage / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000382:microbiology; D014945:Wound Healing / Q000187:drug effects
D000890:Anti-Infective Agents; D007454:Iodides; D048271:Chitosan; D009113:Muramidase; C010389:Lugol's solution; D004121:Dimethyl Sulfoxide