Edward Maxwell (Max) Nicholls (1927-2011), a Key Player in the Development of the Two-Hit Model of Tumor Formation.
E. M. Nicholls (1927-2011) was a humanist, medical practitioner, human biologist, geneticist and, above all, a teacher, as well as a husband and father. He believed that he had made a fundamental contribution to the two-hit model of cancer formation. This hypothesis is associated with retinoblastoma, in particular. Nicholls presented it through his observations on neurofibromatosis. He received little credit for what he believed was his most original contribution to medical science. This note attempts to redress the balance in his favor.
School of Mathematics and Statistics FO7,University of Sydney,New South Wales,Sydney,Australia.
Alan E
AE
Stark
Department of Genetics and Evolutionary Biology,University of Sao Paulo,Sao Paulo,Brazil.
Paulo A
PA
Otto
D035843:Biomedical Research / Q000266:history; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000473:pathology*
germinal; mutation; neurofibromatosis; retinoblastoma; somatic; tumors two-hit model