Two New Triterpenoid Saponins from the Structural Modification of Pseudoginsenoside-F11 and their Cytotoxic Activities.
Two ginsenoside derivatives (1, 2) along with 2 known ginsenosides (3, 4) were isolated from the acid hydrolysis products of pseudoginsenoside-F11. Their structures were elucidated on the basis of spectroscopic analyses, including ID, 2D NMR and HR-ESI-MS. Among them, (12R, 20S, 24S)-20, 24; 12, 24-diepoxy-dammarane-3β, 6α-diol (1) and (20R, 24R)-dammar-20, 24-epoxy-3β, 6α, 12β, 25-tetraol (2) were identified as new triterpenoid saponins. They were subjected to assay for cytotoxic activities against six human tumor cells lines.
Manman
M
Li
Zhicai
Z
Wang
Pengfei
P
Zhang
Yan
Y
Xua
Hongda
H
Ding
Dayuan
D
Sui
Huali
H
Xu
Yanping
Y
Chen
D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D036145:Ginsenosides / Q000737:chemistry*; D006801:Humans; D012503:Saponins / Q000138:chemical synthesis*; D014315:Triterpenes / Q000138:chemical synthesis*
D036145:Ginsenosides; D012503:Saponins; D014315:Triterpenes