Smart surface-enhanced Raman scattering traceable drug delivery systems.
A novel smart nanoparticle-based system has been developed for tracking intracellular drug delivery through surface-enhanced Raman scattering (SERS). This new drug delivery system (DDS) shows targeted cytotoxicity towards cancer cells via pH-cleavable covalent carboxylic hydrazone links and the SERS tracing capability based on gold@silica nanocarriers. Doxorubicin, as a model anticancer drug, was employed to compare SERS with conventional fluorescence tracing approaches. It is evident that SERS demonstrates higher sensitivity and resolution, revealing intracellular details, as the strengths of the original Raman signals can be amplified by SERS. Importantly, non-destructive SERS will provide the designed DDS with great autonomy and potential to study the dynamic procedures of non-fluorescent drug delivery into living cells.
School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia. s.qiao@adelaide.edu.au s.dai@adelaide.edu.au.
Lei
L
Liu
Yonghong
Y
Tang
Sheng
S
Dai
Freddy
F
Kleitz
Shi Zhang
SZ
Qiao
D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006046:Gold; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles; D013059:Spectrum Analysis, Raman
D006046:Gold; D004317:Doxorubicin