Treponema pallidum pallidum Genotypes and Macrolide Resistance Status in Syphilitic Lesions among Patients at 2 Sexually Transmitted Infection Clinics in Lima, Peru.
We report the circulating genotypes and the frequency of macrolide-resistance patterns among Treponema pallidum pallidum DNA isolated from syphilitic lesions from patients who attended 2 sexual health clinics in Lima, Peru. We implemented and used a molecular typing scheme to describe local T. pallidum pallidum strains. Among 14 specimens, subtype 14d/f was the most prevalent strain in 7 fully typed T. pallidum DNA specimens obtained from men who have sex with men and transgender women presenting with chancre-like lesions. No macrolide-resistance mutations were found in T. pallidum DNA from 10 lesions.
From the *Laboratory of Sexual Health, Center for Interdisciplinary Research on Sexuality, AIDS and Society, Universidad Peruana Cayetano Heredia, Lima, Peru; †Program in Global Health, Division of Infectious Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA; ‡Center for Interdisciplinary Research on Sexuality, AIDS and Society, Universidad Peruana Cayetano Heredia, Lima; and §Alberto Barton Clinic, Callao, Peru.
Juan Antonio
JA
Flores
Silver Keith
SK
Vargas
Segundo Ramos
SR
Leon
Danny Giancarlo
DG
Perez
Lourdes Beatriz
LB
Ramos
Jeremy
J
Chow
Kelika Anne
KA
Konda
Gino Mauricio
GM
Calvo
Hector J
HJ
Salvatierra
Jeffrey D
JD
Klausner
Carlos Fernando
CF
Caceres
D024881:Drug Resistance, Bacterial; D005260:Female; D005838:Genotype; D018451:Homosexuality, Male; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D008297:Male; D058889:Molecular Typing; D009154:Mutation; D010568:Peru / Q000453:epidemiology; D015231:Sexually Transmitted Diseases, Bacterial / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D013587:Syphilis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D063106:Transgender Persons; D014210:Treponema pallidum / Q000145:classification / Q000187:drug effects / Q000235:genetics*
D018942:Macrolides