Cytotoxic stilbenes from the roots of Paphiopedilum godefroyae.
Two new stilbenes, 2-(3',5'-dimethoxyphenyl)-6-hydroxy-5-methoxybenzofuran (1) and 3'-hydroxy-2,5'-dimethoxystilbene (2), together with seven known stilbenes (3, 5-10) and one flavanone (4), were isolated from the roots of Paphiopedilum godefroyae. Their chemical structures were determined on the basis of their spectroscopic data. These isolated compounds were evaluated for their cytotoxicity against human small cell lung cancer (NCI-H187) cell lines and an arylbenzofuran derivative, 5,6-dimethoxy-2-(3-hydroxy-5-methoxyphenyl)benzofuran (6), was shown to be strongly cytotoxic with an IC50value of 5.10 μM.
a Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany , Chulalongkorn University , Bangkok , Thailand.
Nonthalert
N
Lertnitikul
a Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany , Chulalongkorn University , Bangkok , Thailand.
Punyada
P
Jittham
a Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany , Chulalongkorn University , Bangkok , Thailand.
Ladapa
L
Khankhampoch
a Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany , Chulalongkorn University , Bangkok , Thailand.
Chutichot
C
Pattamadilok
a Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany , Chulalongkorn University , Bangkok , Thailand.
Suchada
S
Sukrong
a Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany , Chulalongkorn University , Bangkok , Thailand.
Rutt
R
Suttisri
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D029595:Orchidaceae / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013785:Thailand
C000613412:2-(3',5'-dimethoxyphenyl)-6-hydroxy-5-methoxybenzofuran; C000613413:3'-hydroxy-2,5'-dimethoxystilbene; C578235:5,6-dimethoxy-2-(3-hydroxy-5-methoxyphenyl)benzofuran; D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D044950:Flavanones; D013267:Stilbenes; C028610:flavanone
NCI-H187; Orchidaceae; Paphiopedilum godefroyae; cytotoxicity; stilbenes