Efficacy and Safety of a Hyaluronic Acid Filler to Correct Aesthetically Detracting or Deficient Features of the Asian Nose: A Prospective, Open-Label, Long-Term Study.
BACKGROUND
There is increasing interest among patients and plastic surgeons for alternatives to rhinoplasty, a common surgical procedure performed in Asia.


OBJECTIVE
To evaluate the safety, efficacy, and longevity of a hyaluronic acid filler in the correction of aesthetically detracting or deficient features of the Asian nose.


METHODS
Twenty-nine carefully screened Asian patients had their noses corrected with the study filler (Juvéderm VOLUMA [Allergan plc, Dublin, Ireland] with lidocaine injectable gel), reflecting individualized treatment goals and utilizing a standardized injection procedure, and were followed for over 12 months.


RESULTS
A clinically meaningful correction (≥1 grade improvement on the Assessment of Aesthetic Improvement Scale) was achieved in 27 (93.1%) patients at the first follow-up visit. This was maintained in 28 (96.6%) patients at the final visit, based on the independent assessments of a central non-injecting physician and the patients. At this final visit, 23 (79.3%) patients were satisfied or very satisfied with the study filler and 25 (86.2%) would recommend it to others. In this small series of patients, there were no serious adverse events (AEs), with all treatment-related AEs being mild to moderate, transient injection site reactions, unrelated to the study filler.


CONCLUSIONS
Using specific eligibility criteria, individualized treatment goals, and a standardized injection procedure, the study filler corrected aesthetically detracting or deficient features of the Asian nose, with the therapeutic effects lasting for over 12 months, consistent with a high degree of patient satisfaction. This study supports the safety and efficacy of this HA filler for specific nose augmentation procedures in selected Asian patients. LEVEL OF EVIDENCE 3: Therapeutic.
Dr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in São Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore.
Steven
S
Liew
Dr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in São Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore.
Terrence
T
Scamp
Dr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in São Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore.
Mauricio
M
de Maio
Dr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in São Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore.
Michael
M
Halstead
Dr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in São Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore.
Nicole
N
Johnston
Dr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in São Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore.
Michael
M
Silberberg
Dr Liew is a plastic surgeon in private practice in Sydney, NSW, Australia. Dr Scamp is a plastic surgeon in private practice in Main Beach, Queensland, Australia. Dr de Maio is a plastic surgeon in private practice in São Paulo, Brazil. Mr Halstead is Associate Director and Ms Johnston is Study Manager, Scientific & Medical Affairs, plc Australia, Gordon, NSW, Australia. Dr Silberberg is Medical Director, Aesthetics International, Allergan plc, Marlow, United Kingdom. Dr Rogers is Therapeutic Area Medical Director, Scientific & Medical Affairs, Allergan plc, Singapore, Singapore.
John D
JD
Rogers
D000328:Adult; D001208:Asia; D003357:Cosmetic Techniques; D003879:Dermatologic Agents / Q000008:administration & dosage; D004954:Esthetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D009666:Nose; D017060:Patient Satisfaction / Q000706:statistics & numerical data*; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D003879:Dermatologic Agents; C527044:Juvéderm; D006820:Hyaluronic Acid