Anti-inflammatory and antimicrobial coumarins from the stems of Eurya chinensis.
Two new coumarins, named (±)-euryacoumarin A (1) and 6-demethylobtusinin (2), and one new natural coumarin, named euryacoumarin B (3), along with two known compounds, scopoletin (4) and obtusinol (5), were isolated from the stems of Eurya chinensis. Their structures were elucidated by means of extensive spectroscopic methods and comparison with data reported in the literatures. Compound 1 exhibited significant inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 cells with IC50value of 35.64 ± 1.73 μM, and showed marginal antibacterial activities against Bacillus subtilis and B. cereus with MIC values of 50.59 ± 2.12 and 35.42 ± 0.96 μM, respectively.
a Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 570650 , China.|b University of Chinese Academy of Sciences , Beijing 100049 , China.
Jia-Ling
JL
Song
a Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 570650 , China.|b University of Chinese Academy of Sciences , Beijing 100049 , China.
Yao
Y
Yuan
a Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 570650 , China.
Hai-Bo
HB
Tan
a Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 570650 , China.
Ri-Ming
RM
Huang
a Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 570650 , China.
Hong-Xin
HX
Liu
a Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 570650 , China.
Zhi-Fang
ZF
Xu
a Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou 570650 , China.
Sheng-Xiang
SX
Qiu
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis
C000615980:6-demethylobtusinin; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D003374:Coumarins; D008070:Lipopolysaccharides; C000615978:euryacoumarin A; C000615979:euryacoumarin B; D009569:Nitric Oxide
Eurya chinensis; Theaceae; anti-inflammatory; antibacterial; coumarin