Serum adipokines levels in patients with systemic sclerosis: A meta-analysis.
BACKGROUND
Systemic sclerosis is an chronic inflammatory autoimmune diseases. Adipokine has been reported to play an important role in modulating immune responses. Recent studies suggest that adipokine also plays some roles in the pathogenesis of systemic sclerosis (SSc). However, published data regarding the relationship between plasma/serum adipokine levels and SSc are contradictory. The aim of this study was at performing a meta-analysis to derive a more accurate estimation and further investigate the association of plasma/serum leptin and adiponectin levels with SSc patients.


METHODS
PubMed, and Web of Science databases (up to Feb 20, 2016) were used to obtain all relative published literatures. The study quality was assessed by the Newcastle-Ottawa scale. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by random-effect model analysis.


RESULTS
A total of fourteen studies were finally included in this meta-analysis. Among them, six of which were studied for the serum adiponectin levels in SSc patients, six of which were studied for the serum leptin levels in SSc patients, and two of them were studied both for serum adiponectin levels and serum leptin levels in SSc patients. The meta-analysis results showed that the serum adiponectin levels in SSc patients were significantly lower than that in normal controls (SMD = -0.608 ng/ml, 95% CI = -1.029 to -0.186, p = 0.005). However, there were no significant differences in serum leptin levels between SSc patients and healthy controls (SMD = -0.990 ng/ml, 95% CI = -2.340 to 0.359, p = 0.150). The subgroup analysis showed that Asia SSc patients with age less than 50 years old had lower plasma/serum adiponectin levels when compared with controls.


CONCLUSIONS
The serum adiponectin levels, but not serum leptin levels, in SSc patients were significantly lower than that in normal controls.
a West Anhui Health Vocational College , Lu'an , Anhui , PR China.
Jiu-Hua
JH
Zhao
b Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , PR China , and.
Xiao-Lei
XL
Huang
b Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , PR China , and.
Yu
Y
Duan
b Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , PR China , and.
Yu-Jie
YJ
Wang
c Department of Rheumatology and Clinical Immunology , The First Affiliated Hospital, Anhui Medical University , Hefei , PR China.
Shan-Yu
SY
Chen
b Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , PR China , and.
Jing
J
Wang
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D006801:Humans; D020738:Leptin / Q000097:blood*; D012595:Scleroderma, Systemic / Q000097:blood*
D052242:Adiponectin; D020738:Leptin
Adiponectin; Autoimmunity; Fibrosis; Leptin; Systemic sclerosis