Synthesis of the Repeating Unit of Capsular Polysaccharide Staphylococcus aureus Type 5 To Study Chemical Activation and Conjugation of Native CP5.
The chemical synthesis of the repeating unit of S. aureus capsular polysaccharide type 5 equipped with capping methyl groups at the points of propagation of the polysaccharide sequence is described. This model compound was designed to study activation of the full length polysaccharide for conjugation to a carrier protein.
Department of Chemistry and Biochemistry, University of Missouri-St. Louis , One University Boulevard, St. Louis, Missouri 63121, United States ;
Jagodige P
JP
Yasomanee
Department of Chemistry and Biochemistry, University of Missouri-St. Louis , One University Boulevard, St. Louis, Missouri 63121, United States ;
Satsawat
S
Visansirikul
Department of Chemistry and Biochemistry, University of Missouri-St. Louis , One University Boulevard, St. Louis, Missouri 63121, United States ;
Papapida
P
Pornsuriyasak
Analytical R&D, Biotherapeutics Pharmaceutical Sciences, Pfizer, Inc. , 700 Chesterfield Parkway W, Chesterfield, Missouri 63017, United States.
Melissa
M
Thompson
Bioprocess R&D, Biotherapeutics Pharmaceutical Sciences, Pfizer, Inc. , 700 Chesterfield Parkway W, Chesterfield, Missouri 63017, United States ;
Stephen A
SA
Kolodziej
Department of Chemistry and Biochemistry, University of Missouri-St. Louis , One University Boulevard, St. Louis, Missouri 63121, United States ;
Alexei V
AV
Demchenko
D001386:Azides / Q000737:chemistry; D016667:Bacterial Capsules / Q000737:chemistry*; D002625:Chemistry, Organic; D008745:Methylation; D010100:Oxygen / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013211:Staphylococcus aureus / Q000737:chemistry*; D014312:Trisaccharides / Q000737:chemistry; D014574:Uronic Acids / Q000737:chemistry
D001386:Azides; D011134:Polysaccharides; D011135:Polysaccharides, Bacterial; D012997:Solvents; D014312:Trisaccharides; D014574:Uronic Acids; C054106:capsular polysaccharide, type 5, Staphylococcus aureus; D010100:Oxygen