The heme-p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis.
Recently, we reported that heme binds to tumor suppressor p53 protein (TP53, best known as p53) and promotes its nuclear export and cytosolic degradation, whereas iron chelation stabilizes p53 protein and suppresses tumors in a p53-dependent manner. This not only provides mechanistic insights into tumorigenesis associated with iron excess, but also helps guide the administration of chemotherapy based on iron deprivation in the clinic.
CAS Key Laboratory of Systems Biology; Chinese Academy of Sciences; Shanghai, China; University of Chinese Academy of Sciences; Institute of Biochemistry and Cell Biology; Chinese Academy of Sciences; Shanghai, China; Present address: Molecular Biology Institute; University of California-Los Angeles; Los Angeles, CA USA.
Jia
J
Shen
CAS Key Laboratory of Systems Biology; Chinese Academy of Sciences; Shanghai, China; University of Chinese Academy of Sciences; Institute of Biochemistry and Cell Biology; Chinese Academy of Sciences; Shanghai, China; Present address: Molecular Biology Institute; University of California-Los Angeles; Los Angeles, CA USA.
Xiangpeng
X
Sheng
Division of Biology; California Institute of Technology; Pasadena, CA USA; Present address: Molecular Biology Institute; University of California-Los Angeles; Los Angeles, CA USA.
ZeNan
Z
Chang
University of Chinese Academy of Sciences; Institute of Biochemistry and Cell Biology; Chinese Academy of Sciences; Shanghai, China; Institute of Nutritional Sciences; Shanghai Institutes for Biological Sciences; Chinese Academy of Sciences;, Shanghai, China.
Qian
Q
Wu
Division of Biology; California Institute of Technology ; Pasadena, CA USA.
Dong
D
Xie
School of public Health; Zhejiang University ; Zhejiang, China.
Fudi
F
Wang
CAS Key Laboratory of Systems Biology; Chinese Academy of Sciences ; Shanghai, China.
Ronggui
R
Hu
heme; hemochromatosis; iron deprivation; nuclear export; p53; tumorigenesis