Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy.
Ehrlichia chaffeensis is a small, gram negative, obligately intracellular bacterium that preferentially infects mononuclear phagocytes. It is the etiologic agent of human monocytotropic ehrlichiosis (HME), an emerging life-threatening tick-borne zoonosis. Mechanisms by which E. chaffeensis establishes intracellular infection, and avoids host defenses are not well understood, but involve functionally relevant host-pathogen interactions associated with tandem and ankyrin repeat effector proteins. In this review, we discuss the recent advances in our understanding of the molecular and cellular mechanisms that underlie Ehrlichia host cellular reprogramming strategies that enable intracellular survival.
Department of Pathology, University of Texas Medical Branch Galveston, TX, USA.
Taslima T
TT
Lina
Department of Pathology, University of Texas Medical Branch Galveston, TX, USA.
Tierra
T
Farris
Department of Pathology, University of Texas Medical Branch Galveston, TX, USA.
Tian
T
Luo
Department of Pathology, University of Texas Medical Branch Galveston, TX, USA.
Shubhajit
S
Mitra
Department of Pathology, University of Texas Medical Branch Galveston, TX, USA.
Bing
B
Zhu
Department of Pathology, University of Texas Medical BranchGalveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical BranchGalveston, TX, USA; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical BranchGalveston, TX, USA; Sealy Center for Vaccine Development, University of Texas Medical BranchGalveston, TX, USA; Institute for Human Infections and Immunity, University of Texas Medical BranchGalveston, TX, USA.
Jere W
JW
McBride
D000818:Animals; D001426:Bacterial Proteins / Q000276:immunology*; D018469:Ehrlichia chaffeensis / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D010586:Phagocytes / Q000276:immunology*; D037521:Virulence Factors / Q000276:immunology*
D001426:Bacterial Proteins; D037521:Virulence Factors
Ehrlichia chaffeensis; cell signaling; epigenetics; innate immune response; post translational modification (PTM); secretion system; tandem repeat proteins (TRPs)