The optogenetic promise for oncology: Episode I.
As light-based control of fundamental signaling pathways is becoming a reality, the field of optogenetics is rapidly moving beyond neuroscience. We have recently developed receptor tyrosine kinases that are activated by light and control cell proliferation, epithelial-mesenchymal transition, and angiogenic sprouting-cell behaviors central to cancer progression.
IST Austria (Institute of Science and Technology Austria) ; Klosterneuburg, Austria.
Alvaro
A
Ingles-Prieto
IST Austria (Institute of Science and Technology Austria) ; Klosterneuburg, Austria.
Eva
E
Reichhart
Institute of Cancer Research; Department of Medicine I; Comprehensive Cancer Center Vienna; Medical University of Vienna ; Vienna, Austria.
Karin
K
Schelch
IST Austria (Institute of Science and Technology Austria) ; Klosterneuburg, Austria.
Harald
H
Janovjak
Institute of Cancer Research; Department of Medicine I; Comprehensive Cancer Center Vienna; Medical University of Vienna ; Vienna, Austria.
Michael
M
Grusch
Optogenetics; hallmarks of cancer; receptor tyrosine kinase; spatio-temporal control; synthetic physiology