A New Bibenzyl-phenanthrene Derivative from Dendrobium signatum and its Cytotoxic Activity.
From the whole plant of Dendrobium signatum, a new bibenzyl-dihydrophenanthrene derivative, named dendrosignatol was isolated, together with the known compounds 3,4-dihydroxy-3,4'-dimethoxybibenzyl, dendrocandin B, dendrocandin I and dendrofalconerol A. The structure of the new compound was elucidated through analysis of its spectroscopic and mass spectrometric data. All of the isolates showed appreciable cytotoxic activity against three human cancer cell lines, including MDA-23 1, HepG2 and HT-29 cells.
Arparporn
A
Mittraphab
Chawanphat
C
Muangnoi
Kittisak
K
Likhitwitayawuid
Pornchai
P
Rojsitthisak
Boonchoo
B
Sritularak
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D001593:Benzyl Compounds / Q000737:chemistry / Q000302:isolation & purification*; D031667:Dendrobium / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification*
D000972:Antineoplastic Agents, Phytogenic; D001593:Benzyl Compounds; D010616:Phenanthrenes; C000609557:dendrosignatol