Protective effects of phillyrin against influenza A virus in vivo.
Influenza A virus infection represents a great threat to public health. However, owing to side effects and the emergence of resistant virus strains, the use of currently available anti-influenza drugs may be limited. In order to identify novel anti-influenza drugs, we investigated the antiviral effects of phillyrin against influenza A virus infection in vivo. The mean survival time, lung index, viral titers, influenza hemagglutinin (HA) protein and serum cytokines levels, and histopathological changes in lung tissue were examined. Administration of phillyrin at a dose of 20 mg/kg/day for 3 days significantly prolonged the mean survival time, reduced the lung index, decreased the virus titers and interleukin-6 levels, reduced the expression of HA, and attenuated lung tissue damage in mice infected with influenza A virus. Taken together, these data showed that phillyrin had potential protective effects against infection caused by influenza A virus.
Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, 100850, Beijing, People's Republic of China.
Xin-Yan
XY
Qu
Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, 100850, Beijing, People's Republic of China.
Qing-Jun
QJ
Li
Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250355, China.
Hui-Min
HM
Zhang
Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, 100850, Beijing, People's Republic of China.
Xiao-Juan
XJ
Zhang
Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, 100850, Beijing, People's Republic of China.
Peng-Hui
PH
Shi
Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, 100850, Beijing, People's Republic of China.
Xiu-Juan
XJ
Zhang
Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, 100850, Beijing, People's Republic of China. jingyang0511@sina.com.
Jing
J
Yang
Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, 100850, Beijing, People's Republic of China. zhouzhe@bmi.ac.cn.
Zhe
Z
Zhou
Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, 100850, Beijing, People's Republic of China. sqwang@nic.bmi.ac.cn.
Sheng-Qi
SQ
Wang
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004285:Dogs; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects* / Q000502:physiology; D007251:Influenza, Human / Q000473:pathology / Q000517:prevention & control*; D061985:Madin Darby Canine Kidney Cells; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use
D000998:Antiviral Agents; D005960:Glucosides; D020011:Protective Agents; C075528:phillyrin
Influenza A virus; Mouse; Phillyrin