Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA.
The recent development of biohybrid catalytic systems has allowed synthetic chemists to reach high levels of selectivity on a wide variety of valuable synthetic transformations. In this context, DNA-based catalysts have emerged as particularly appealing tools. Interestingly, while long RNA sequences (ribozymes) are known to catalyse specific biochemical reactions with remarkable efficiencies, RNA-based catalysts involving a catalytically active metal complex interacting in a non-covalent fashion with short sequences have never been evaluated to date. We report here our results, which have led to the first example involving a short RNA-based catalyst.
Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI) - ESPCI ParisTech/CNRS (UMR8231)/PSL* Research University, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
Nicolas
N
Duchemin
Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI) - ESPCI ParisTech/CNRS (UMR8231)/PSL* Research University, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
Erica
E
Benedetti
NOXXON Pharma AG, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.
Lucas
L
Bethge
NOXXON Pharma AG, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.
Stefan
S
Vonhoff
NOXXON Pharma AG, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.
Sven
S
Klussmann
Institut des Biomolécules Max Mousseron, UMR 5247 CNRS, Université de Montpellier, ENSCM Place Eugène Bataillon, 34095 Montpellier, France. michael.smietana@umontpellier.fr.
Jean-Jacques
JJ
Vasseur
Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI) - ESPCI ParisTech/CNRS (UMR8231)/PSL* Research University, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
Janine
J
Cossy
Institut des Biomolécules Max Mousseron, UMR 5247 CNRS, Université de Montpellier, ENSCM Place Eugène Bataillon, 34095 Montpellier, France. michael.smietana@umontpellier.fr.
Michael
M
Smietana
Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI) - ESPCI ParisTech/CNRS (UMR8231)/PSL* Research University, 10 rue Vauquelin, 75231 Paris Cedex 05, France and School of Biological and Chemical Sciences, Queen Mary University of London, Joseph Priestley Building, Mile End Road, London E1 4NS, UK. s.arseniyadis@qmul.ac.uk.
Stellios
S
Arseniyadis
D000478:Alkylation; D055162:Biocatalysis; D009690:Nucleic Acid Conformation; D016337:RNA, Catalytic / Q000737:chemistry / Q000378:metabolism*; D012997:Solvents / Q000737:chemistry
D016337:RNA, Catalytic; D012997:Solvents