Phytochemical Analysis and Gastroprotective Activity of the Root Bark from Maytenus robusta.
The present work evaluated the chemical composition and antiulcerogenic potential of the crude extract, fractions and pure compounds isolated of roots barks from Maytenus robusta Reiss, using different pharmacological models in mice. 3,12-Dioxofriedelane (1) and 11-hydroxylup-20 (29)-en-3-one (2) were isolated from the n-hexane fraction, and mayteine (3) and 3,7-dioxofriedelane (4) from the dichloromethane fraction. The crude extract (50, 259, 500 mg/kg), all the fractions (250 mg/kg) and cimetidine (100 mg/kg) significantly reduced the lesion index, total lesion area, and percentage of lesions, in comparison with the control group (p < 0.05), by ethanol and NSAID-induced ulcer models. All the isolated compounds also presented significant pharmacological effects at 30 mg/kg. These results show that the root bark of M. robusta may be a promising source of molecules with applicability in the treatment of gastric disorders.
Danyela Francine
DF
Benvenutti
Franco
F
Della Monache
Valdir
V
Cechinel Filho
Sérgio Faloni
SF
de Andrade
Rivaldo
R
Niero
D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification*; D004353:Drug Evaluation, Preclinical; D008297:Male; D029755:Maytenus / Q000737:chemistry*; D051379:Mice; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D011897:Random Allocation
D000897:Anti-Ulcer Agents