Mechanisms involved in the neurotoxic and cognitive effects of developmental methamphetamine exposure.
Methamphetamine exposure in utero leads to a variety of higher-order cognitive deficits, such as decreased attention and working, and spatial memory impairments in exposed children (Piper et al., 2011; Roussotte et al., 2011; Kiblawi et al., 2011). As with other teratogens, the timing of methamphetamine exposure greatly determines its effects on both neuroanatomical and behavioral outcomes. Methamphetamine exposure in rodents during the third trimester human equivalent period of brain development results in distinct and long-lasting route-based and spatial navigation deficits (Williams et al., 2003; Vorhees et al., 2005, 2008, 2009;). Here, we examine the impact of neonatal methamphetamine-induced neurotoxicity on behavioral outcomes, neurotransmission, receptor changes, plasticity proteins, and DNA damage. Birth Defects Research (Part C) 108:131-141, 2016. © 2016 Wiley Periodicals, Inc.
Department of Pediatrics, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Sarah A
SA
Jablonski
Department of Pediatrics, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Michael T
MT
Williams
Department of Pediatrics, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Charles V
CV
Vorhees
D000818:Animals; D000831:Animals, Newborn; D003071:Cognition / Q000187:drug effects*; D005260:Female; D006801:Humans; D008694:Methamphetamine / Q000009:adverse effects* / Q000378:metabolism; D065886:Neurodevelopmental Disorders / Q000378:metabolism / Q000503:physiopathology; D020258:Neurotoxicity Syndromes / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D018384:Oxidative Stress / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D008694:Methamphetamine
developmental neurotoxicity; dopamine; methamphetamine; neonatal exposure