IMMUNOLOGICAL IMPLICATIONS IN MAMMALIAN SEMI-ALLOGENEIC PREGNANCY.
The mammalian conceptus is a semi-allograft. The maternal tolerance towards semi-allograft is primed by a battery of cytokines and resident decidual cells. Invasion of embryonic trophoblast, decidual vascular remodeling and unresponsive incipient 'Triple-negative' (CD3-, CD4- and CD8-) T-cells of foetus promote normal pregnancy. On the other hand, the maternal cytokine profile shift towards Th1 response is shown to enhance the risk during pregnancy. The periodical examination of maternal serum levels of Th1 and Th2 response mediated cytokines constitutes prognostic biomarkers to initiate therapeutic regimens.
Srirama
S
Krupanidhi
D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D003656:Decidua / Q000254:growth & development / Q000276:immunology; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000276:immunology*; D014327:Trophoblasts / Q000276:immunology
D016207:Cytokines