Dissecting the bone marrow HSC niches.
Hematopoietic stem cells (HSCs) sponsoring hematopoiesis are preserved in the bone marrow (BM) microenvironment or niche. Here, Itkin et al. demonstrate how distinct blood vessels contribute to HSC maintenance and hematopoiesis in the BM niches.
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.|Center for Stem Cell Biology and Tissue Engineering, Department of Pathophysiology, Zhongshan Medical School, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
Meng
M
Zhao
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.|Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Linheng
L
Li
D001853:Bone Marrow; D001854:Bone Marrow Cells; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells