Molecular mechanisms involved in initiation of the DNA damage response.
DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. The initiating events in the DNA damage response entail recognition of the lesion and the assembly of DNA damage response complexes at the DNA. Here, we review what is known about these processes for various DNA damage pathways.
Department of Oncological Sciences and the Graduate School of Biomedical Sciences; Icahn School of Medicine at Mount Sinai ; New York, NY USA.
Kevin J
KJ
Barnum
Department of Oncological Sciences and the Graduate School of Biomedical Sciences; Icahn School of Medicine at Mount Sinai ; New York, NY USA.
Matthew J
MJ
O'Connell
DNA damage; checkpoint; excision; nuclease; recombination; repair; replication; transcription