Δ113p53/Δ133p53 converts P53 from a repressor to a promoter of DNA double-stand break repair.
In response to DNA damage, p53 (TP53, best known as p53) is quickly activated leading to cell cycle arrest or apoptosis to ensure genomic integrity; however, this represses DNA double-strand break (DSB) repair. Our recent work revealed that Δ113p53/Δ133p53 protein is accumulated at a later stage upon DNA DSB stress to switch p53 signaling from repression to promotion of DNA DSB repair.
Key laboratory for Molecular Animal Nutrition, Ministry of Education, College of Life Sciences, Zhejiang University , Hangzhou, China.
Lu
L
Gong
Key laboratory for Molecular Animal Nutrition, Ministry of Education, College of Life Sciences, Zhejiang University , Hangzhou, China.
Jun
J
Chen
Cell death; HR; NHEJ; SSA; p53 isoform Δ113p53/Δ133p53; senescence