Analysis of intratumor heterogeneity unravels lung cancer evolution.
Lung cancer is a disease with dismal outcome. We recently reported a detailed intratumor heterogeneity analysis in 7 non-small cell lung cancer samples, revealing spatially separated driver events as well as the temporal dynamics of mutational processes and demonstrating an important role for APOBEC-mediated heterogeneity later in disease evolution.
Cancer Institute; UK by Cancer Institute ; London, UK.
Elza C
EC
de Bruin
Centre for Mathematics & Physics in the Life Science & Experimental Biology (CoMPLEX); University College London; London, UK; Cancer Research UK London Research Institute; London, UK.
Nicholas
N
McGranahan
Cancer Institute; UK by Cancer Institute; London, UK; Cancer Research UK London Research Institute; London, UK.
Charles
C
Swanton
APOBEC; intratumor heterogeneity; lung cancer; multi-region sequencing