Recent advances of cytotoxic chalconoids targeting tubulin polymerization: Synthesis and biological activity.
Since microtubules have an important role in mitosis and other vital cellular functions, tubulin-targeting chemotherapy has been received growing attention in anticancer drug design and development. It was found that a number of naturally occurring compounds including distinct chalcones exert their effect by inhibition of tubulin polymerization. After the identification of tubulin polymerization as potential target for chalcone-type compounds, extensive researches have been made to design and synthesis of new anti-tubulin chalconoids. Although diverse chalcones have found to be potent anticancer agents but in the present review, we focused on the recently reported tubulin polymerization inhibitors from chalcone origin and related synthetic compounds, and their detailed synthetic methods and biological activities.
Student Research Committee, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Hassan
H
Mirzaei
Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: sd_emami@yahoo.com.
Saeed
S
Emami
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D047188:Chalcones / Q000138:chemical synthesis* / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D006801:Humans; D055503:Protein Multimerization / Q000187:drug effects*; D014404:Tubulin / Q000737:chemistry*; D050257:Tubulin Modulators / Q000138:chemical synthesis / Q000494:pharmacology
D000970:Antineoplastic Agents; D047188:Chalcones; D014404:Tubulin; D050257:Tubulin Modulators
1,3-Diaryl-2-propen-1-ones; Anti-cancer; Chalcones; Cytotoxic activity; Tubulin polymerization