Multifocal infantile haemangioma: a diagnostic challenge.
We describe a case of a newborn who presented with multiple dark red macules that developed into red-to-purple papules associated with thrombocytopaenia. Abdominal ultrasound showed multiple hyperechoic papules and nodules. Endothelial cells from a skin biopsy stained positively for endothelial cell glucose transporter 1, which was consistent with a diagnosis of multifocal infantile haemangioma. At the age of 2 months, the child developed intestinal bleeding and anaemia. Upper and lower endoscopies showed no intestinal haemangiomas. Oral treatment with propranolol (3 mg/kg/day) resulted in complete involution of the skin and hepatic haemangiomas over the period of treatment, which lasted until the child was aged 15 months. This is a rare case of multifocal cutaneous haemangioma with hepatic and probable intestinal involvement, successfully treated with propranolol.
Serviço de Pediatria, Hospital Faro, Centro Hospitalar Algarve, Faro, Portugal.
Erica
E
Torres
Serviço de Pediatria, Hospital Faro, Centro Hospitalar Algarve, Faro, Portugal.
João
J
Rosa
CHU Bordeaux, Bordeaux, France.
Christine
C
Leaute-Labreze
Department of Dermatology, Hospital de Santa Maria-Centro Hospitalar de Lisboa Norte, Lisbon, Portugal.
Luis
L
Soares-de-Almeida
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000740:Anemia / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D006391:Hemangioma / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007410:Intestinal Diseases / Q000150:complications* / Q000175:diagnosis; D008297:Male; D011433:Propranolol / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D011433:Propranolol