Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer.
Squamous lung cancer is a subtype of non-small cell lung cancer with a poor overall prognosis. We have recently generated a mouse model of squamous lung carcinoma by overexpressing Sex-determining region Y-box 2 (Sox2) and deleting liver kinase B1 (Lkb1) using a lentiviral approach. This model recapitulates the human disease in terms of histopathology, biomarker expression, and signaling pathway activation, making it an excellent model for preclinical studies.
Department of Oncological Sciences; University of Utah and Huntsman Cancer Institute ; Salt Lake City, UT USA.
Anandaroop
A
Mukhopadhyay
Department of Oncological Sciences; University of Utah and Huntsman Cancer Institute ; Salt Lake City, UT USA.
Trudy G
TG
Oliver
Sox2; lung cancer; mouse models; squamous