Adjusting Circumpapillary Retinal Nerve Fiber Layer Profile Using Retinal Artery Position Improves the Structure-Function Relationship in Glaucoma.
To investigate whether correcting the circumpapillary retinal nerve fiber layer (cpRNFL) thickness profile, using retinal artery position and papillomacular bundle tilt, can improve the structure-function relationship in glaucoma patients.



Spectral-domain optical coherence tomography (SD-OCT) and visual field measurements were conducted in 142 eyes of 90 subjects with open angle glaucoma. The SD-OCT cpRNFL thickness profile was corrected for retinal artery position and/or papillomacular tilt in all twelve 30° sectors of the optic disc, and the structure-function relationship against corresponding 30° sectorial retinal sensitivity was investigated by using linear mixed model.



Applying a correction to the cpRNFL thickness profile for retinal artery position resulted in a stronger structure-function relationship in all 12 sectors of the optic disc. Furthermore, applying a further adjustment for papillomacular tilt resulted in a further improvement in 9 of 12 sectors.



Correcting cpRNFL profile, using the retinal artery position significantly strengthened the structure-function relationship. In most optic disc sectors, using the papillomacular bundle tilt improved cpRNFL thickness measurements.
Department of Ophthalmology The University of Tokyo, Tokyo, Japan.
Yuri
Y
Fujino
Department of Ophthalmology Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Takehiro
T
Yamashita
Department of Ophthalmology The University of Tokyo, Tokyo, Japan.
Hiroshi
H
Murata
Department of Ophthalmology The University of Tokyo, Tokyo, Japan.
Ryo
R
Asaoka
D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000000981:diagnostic imaging*; D012161:Retinal Artery / Q000000981:diagnostic imaging*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014794:Visual Fields