Palisaded neutrophilic and granulomatous dermatitis - cutaneous manifestation of Lyme disease or connected with CTD? Case report.
BACKGROUND
Palisaded neutrophilic and granulomatous dermatitis (PNGD) are terms which include such diseases as rheumatoid nodules, Churg-Strauss granuloma, and interstitial granulomatous dermatitis with arthritis. This heterogeneous group was first described in 1965. It is associated with immunological diseases. There are reported cases of coexistence with systemic lupus erythematosus, rheumatoid arthritis, Wegener's granuloma, inflammatory bowel disease, generalized vascular inflammation, and lymphoproliferative disorders. The etiology of the disease is unknown. It is probable that the deposition of immune complexes in blood vessels leads to cutaneus leukocytoclastic vasculitis, degeneration of collagen fibres and palisaded granulomatous inflammation. Ultimately, this leads to fibrosis of the skin.


OBJECTIVE
The aim of the study is to present a patient with skin lesions and histopathological features of palisaded neutrophilic and granulomatous dermatitis during the course of infection Borrelia burgdorferi. Several cases of this disease have been reported worldwide (30 entries in the PubMed database). To-date, there have been no reports of PNGD in Polish literature.


METHODS
The patient, aged 72, was admitted to hospital because of erythematous, indurated lesion of the skin on the side surface of the left thigh. Diagnosis of PNGD was made on the basis of typical histopathologic features due to clinical symptoms.


CONCLUSIONS
Clinical diagnosis of PNGD is difficult, and is based mainly on the histopathological picture. Systemic therapy is incorporated mainly due to the systemic disease. The patient requires further observation in the direction of associated systemic disorders.
Department of Dermatology, Jagiellonian University Medical College, Cracow, Poland.
Magdalena
M
Pirowska
Department of Dermatology, Jagiellonian University Medical College, Cracow, Poland.
Aleksander
A
Obtułowicz
Department of Pathomorphology, Jagiellonian University Medical College, Cracow, Poland.
Grzegorz
G
Dyduch
Department of Dermatology, Jagiellonian University Medical College, Cracow, Poland.
Sylwia
S
Lipko-Godlewska
Department of Dermatology, Jagiellonian University Medical College, Cracow, Poland.
Anna
A
Wojas-Pelc
D000368:Aged; D025065:Borrelia burgdorferi / Q000502:physiology*; D005260:Female; D006099:Granuloma / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D006801:Humans; D008193:Lyme Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D012871:Skin Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology